WorldWideScience

Sample records for evaluate blood safety

  1. An evaluation of sharp safety blood evacuation devices.

    Science.gov (United States)

    Ford, Joanna; Phillips, Peter

    This article describes an evaluation of three sharp safety blood evacuation devices in seven Welsh NHS boards and the Welsh Blood Service. Products consisted of two phlebotomy needles possessing safety shields and one phlebotomy device with wings, tubing and a retractable needle. The device companies provided the devices and appropriate training. Participating healthcare workers used the safety device instead of the conventional device to sample blood during the evaluation period and each type of device was evaluated in random order. Participants filled in a questionnaire for each type of device and then a further questionnaire comparing the two shielded evacuation needles with each other Results showed that responses to all three products were fairly positive, although each device was not liked by everyone who used it. When the two shielded evacuation devices were compared with each other, most users preferred the device with the shield positioned directly above the needle to the device with the shield at the side. However, in laboratory tests, the preferred device produced more fluid splatter than the other shielded device on activation.

  2. Modelling blood safety

    NARCIS (Netherlands)

    Janssen, M.P.

    2010-01-01

    This thesis describes the development and application of methods and models to support decision making on safety measures aimed at preventing the transmission of infections by blood donors. Safety measures refer to screening tests for blood donors, quarantine periods for blood plasma, or methods for

  3. Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation.

    Directory of Open Access Journals (Sweden)

    Rolf Burghaus

    Full Text Available Rivaroxaban is an oral, direct Factor Xa inhibitor approved in the European Union and several other countries for the prevention of venous thromboembolism in adult patients undergoing elective hip or knee replacement surgery and is in advanced clinical development for the treatment of thromboembolic disorders. Its mechanism of action is antithrombin independent and differs from that of other anticoagulants, such as warfarin (a vitamin K antagonist, enoxaparin (an indirect thrombin/Factor Xa inhibitor and dabigatran (a direct thrombin inhibitor. A blood coagulation computer model has been developed, based on several published models and preclinical and clinical data. Unlike previous models, the current model takes into account both the intrinsic and extrinsic pathways of the coagulation cascade, and possesses some unique features, including a blood flow component and a portfolio of drug action mechanisms. This study aimed to use the model to compare the mechanism of action of rivaroxaban with that of warfarin, and to evaluate the efficacy and safety of different rivaroxaban doses with other anticoagulants included in the model. Rather than reproducing known standard clinical measurements, such as the prothrombin time and activated partial thromboplastin time clotting tests, the anticoagulant benchmarking was based on a simulation of physiologically plausible clotting scenarios. Compared with warfarin, rivaroxaban showed a favourable sensitivity for tissue factor concentration inducing clotting, and a steep concentration-effect relationship, rapidly flattening towards higher inhibitor concentrations, both suggesting a broad therapeutic window. The predicted dosing window is highly accordant with the final dose recommendation based upon extensive clinical studies.

  4. Globalisation and blood safety.

    Science.gov (United States)

    Farrugia, Albert

    2009-05-01

    Globalisation may be viewed as the growing interdependence of countries worldwide through the increasing volume and variety of cross-border transactions in goods and services, and also through the more rapid and widespread diffusion of technology. Globalisation is not just an economic phenomenon, although it is frequently described as such, but includes commerce, disease and travel, and immigration, and as such it affects blood safety and supply in various ways. The relatively short travel times offered by modern aviation can result in the rapid spread of blood-borne pathogens before measures to counteract transmission can be put in place; this would have happened with SARS if the basic life cycle of the SARS virus included an asymptomatic viraemia. This risk can be amplified by ecological factors which effect the spread of these pathogens once they are transferred to a naïve ecosystem, as happened with West Nile Virus (WNV) in North America. The rationalization and contraction of the plasma products industry may be viewed as one aspect of globalisation imposed by the remorseless inevitability of the market; the effect of this development on the safety and supply of products has yet to be seen, but the oversight and assurance of a shrinking number of players will present particular challenges. Similarly, the monopolization of technology, through patent enforcement which puts access beyond the reach of developing countries, can have an effect on blood safety. The challenges presented to blood safety by globalisation are heightening the tensions between the traditional focus on the product safety - zero risk paradigm and the need to view the delivery of safe blood as an integrated process. As an illustration of this tension, donor deferral measures imposed by globalisation-induced risks such as vCJD and WNV have resulted in the loss of the safest and most committed portion of the blood donor population in many Western countries, leading to an increased risk to

  5. [Innovative technology and blood safety].

    Science.gov (United States)

    Begue, S; Morel, P; Djoudi, R

    2016-11-01

    If technological innovations are not enough alone to improve blood safety, their contributions for several decades in blood transfusion are major. The improvement of blood donation (new apheresis devices, RFID) or blood components (additive solutions, pathogen reduction technology, automated processing of platelets concentrates) or manufacturing process of these products (by automated processing of whole blood), all these steps where technological innovations were implemented, lead us to better traceability, more efficient processes, quality improvement of blood products and therefore increased blood safety for blood donors and patients. If we are on the threshold of a great change with the progress of pathogen reduction technology (for whole blood and red blood cells), we hope to see production of ex vivo red blood cells or platelets who are real and who open new conceptual paths on blood safety. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  6. Health economics of blood transfusion safety

    NARCIS (Netherlands)

    Hulst, Marinus van

    2008-01-01

    The HIV/AIDS disaster in transfusion medicine shaped the future agendas for blood transfusion safety. More than ever before, the implementation of interventions which could improve blood transfusion safety was driven merely by availability of technology. The introduction of new expensive

  7. Safety evaluation of phytosterols in laying hens: effects on laying performance, clinical blood parameters, and organ development.

    Science.gov (United States)

    Shi, S R; Shen, Y R; Chang, L L; Zhou, C J; Bo, Z; Wang, Z Y; Tong, H B; Zou, J M

    2014-03-01

    Phytosterols are intended for use as a novel food ingredient with plasma cholesterol-lowering activity. Although phytosterols are naturally present in the normal diet, daily consumption is insufficient to ensure plasma cholesterol-lowering levels. Therefore, phytosterols may be added to the diets to achieve the desired cholesterol-lowering activity. A subchronic laying hen safety study was conducted to examine if high-dose phytosterols could affect the safety of hens. Three hundred sixty 21-wk-old Hy-Line Brown laying hens were randomly assigned to 5 groups with 6 replicates of 12 birds each; after 3 wk, birds were fed diets supplemented with 0, 20, 80, 400, and 800 mg/kg of phytosterols for 12 wk. Throughout the study, clinical observations and laying performance were measured. At the end of the study, birds were subjected to a full postmortem examination: blood samples were taken for clinical pathology, selected organs were weighed, and specified tissues were taken for subsequent histological examination. No treatment-related changes that were considered to be of toxicological significance were observed. Therefore, a nominal phytosterol concentration of 800 mg/kg was considered to be the no-observed-adverse-effect level.

  8. Blood transfusion safety: a new philosophy.

    Science.gov (United States)

    Franklin, I M

    2012-12-01

    Blood transfusion safety has had a chequered history, and there are current and future challenges. Internationally, there is no clear consensus for many aspects of the provision of safe blood, although pan-national legislation does provide a baseline framework in the European Union. Costs are rising, and new safety measures can appear expensive, especially when tested against some other medical interventions, such as cancer treatment and vaccination programmes. In this article, it is proposed that a comprehensive approach is taken to the issue of blood transfusion safety that considers all aspects of the process rather than considering only new measures. The need for an agreed level of safety for specified and unknown risks is also suggested. The importance of providing care and support for those inadvertently injured as a result of transfusion problems is also made. Given that the current blood safety decision process often uses a utilitarian principle for decision making--through the calculation of Quality Adjusted Life Years--an alternative philosophy is proposed. A social contract for blood safety, based on the principles of 'justice as fairness' developed by John Rawls, is recommended as a means of providing an agreed level of safety, containing costs and providing support for any adverse outcomes. © 2012 The Author. Transfusion Medicine © 2012 British Blood Transfusion Society.

  9. Blood safety in the world updated

    Institute of Scientific and Technical Information of China (English)

    Silvano Wandel

    2010-01-01

    @@ Blood safety is of paramount importance in any medical context, given that it represents one of the most impor-tant supportive procedures in medicine. Nearly all medical fields that lead with very critical patients will depend on blood products as part of supporting medical strategies (both clinical and surgical). Thus, it is im-portant that every country in the world relies on a well established national blood program.

  10. Blood alcohol test results of motor vehicle deaths as an evaluation method for the Fairfax Alcohol Safety Action Project.

    Science.gov (United States)

    1973-01-01

    The Fairfax Alcohol Safety Action Project (ASAP) was started following the June 1971 approval of the proposal and working plan submitted to the Department of Transportation by the Highway Safety Division of Virginia. A total of $2,123,000 was allocat...

  11. Evaluating ocular blood flow

    Directory of Open Access Journals (Sweden)

    Jyotsna Maram

    2017-01-01

    Full Text Available Studies have shown that vascular impairment plays an important role in the etiology and pathogenesis of various ocular diseases including glaucoma, age-related macular degeneration, diabetic retinopathy, and retinal venous occlusive disease. Thus, qualitative and quantitative assessment of ocular blood flow (BF is a topic of interest for early disease detection, diagnosis, and management. Owing to the rapid improvement in technology, there are several invasive and noninvasive techniques available for evaluating ocular BF, with each of these techniques having their own limitations and advantages. This article reviews these important techniques, with a particular focus on Doppler Fourier domain optical coherence tomography (OCT and OCT-angiography.

  12. Safety evaluation of zinc methionine in laying hens: Effects on laying performance, clinical blood parameters, organ development, and histopathology.

    Science.gov (United States)

    Chen, N N; Liu, B; Xiong, P W; Guo, Y; He, J N; Hou, C C; Ma, L X; Yu, D Y

    2018-04-01

    The study was conducted to investigate whether high-dose zinc methionine (Zn-Met) affected the safety of laying hens, including laying performance, hematological parameters, serum chemical parameters, organ index, and histopathology. A total of 540 20-week-old Hy-Line White laying hens was randomly allocated to 6 groups with 6 replicates of 15 birds each. Birds were fed diets supplemented with 0 (control), 70, 140, 350, 700, or 1,400 mg Zn/kg diet as Zn-Met. The experiment lasted for 8 wk after a 2-week acclimation period. Results showed that dietary supplementation with 70 or 140 mg Zn/kg diet as Zn-Met significantly increased average daily egg mass (ADEM), laying rate (LR), and feed conversion ratio (FCR) (P hens fed with 0, 350, or 700 mg Zn/kg as Zn-Met (P > 0.05); hens administered 1,400 mg Zn/kg showed a significant increase in BSER and remarkable decreases in ADEM, LR, and FCR (P hens receiving 0, 70, 140, 350, or 700 mg Zn/kg as Zn-Met in serum chemical parameters (P > 0.05); supplementation with 1,400 mg Zn/kg as Zn-Met remarkably elevated the concentrations of serum total bilirubin (TBILI), glucose (GLU), uric acid (UA), and creatinine (CRE) (P hens administered 0, 70, 140, 350, or 700 mg Zn/kg as Zn-Met, while significant histological lesions were observed in the heart, liver, lung, and kidney tissues of hens receiving 1,400 mg Zn/kg as Zn-Met. No significant differences were detected in hematological parameters or organ index (P > 0.05). In conclusion, a nominal Zn concentration of 700 mg/kg as Zn-Met is considered to be no-observed-adverse-effect level following daily administration to hens for 56 days.

  13. Evaluation of reactor safety

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1960-04-15

    Although the operation of nuclear reactors has a remarkably good record of safety, the prevention of possible reactor accidents is one of the major factors that atomic planners have to contend with. At the same time, excessive caution may breed an attitude that hampers progress, either by resisting new development or by demanding unnecessarily elaborate and expensive precautions out of proportion to the actual hazards involved. The best course obviously is to determine the possible dangers and adopt adequate measures for their prevention, providing of course, for a reasonable margin of error in judging the hazards and the effectiveness of the measures. The greater the expert understanding and thoroughness with which this is done, the narrower need the margin be. This is the basic idea behind the evaluation of reactor safety

  14. Temporary disruption of the blood-brain barrier by use of ultrasound and microbubbles: safety and efficacy evaluation in rhesus macaques.

    Science.gov (United States)

    McDannold, Nathan; Arvanitis, Costas D; Vykhodtseva, Natalia; Livingstone, Margaret S

    2012-07-15

    The blood-brain barrier (BBB) prevents entry of most drugs into the brain and is a major hurdle to the use of drugs for brain tumors and other central nervous system disorders. Work in small animals has shown that ultrasound combined with an intravenously circulating microbubble agent can temporarily permeabilize the BBB. Here, we evaluated whether this targeted drug delivery method can be applied safely, reliably, and in a controlled manner on rhesus macaques using a focused ultrasound system. We identified a clear safety window during which BBB disruption could be produced without evident tissue damage, and the acoustic pressure amplitude where the probability for BBB disruption was 50% and was found to be half of the value that would produce tissue damage. Acoustic emission measurements seem promising for predicting BBB disruption and damage. In addition, we conducted repeated BBB disruption to central visual field targets over several weeks in animals trained to conduct complex visual acuity tasks. All animals recovered from each session without behavioral deficits, visual deficits, or loss in visual acuity. Together, our findings show that BBB disruption can be reliably and repeatedly produced without evident histologic or functional damage in a clinically relevant animal model using a clinical device. These results therefore support clinical testing of this noninvasive-targeted drug delivery method.

  15. Evaluation of repository safety

    Energy Technology Data Exchange (ETDEWEB)

    Sagar, B.; Patrick, W.; Dasgupta, B.; Mohanty, S. [Center for Nuclear Waste Regulatory Analyses, San Antonio (United States)

    2002-07-01

    The United States high-level waste program requires evaluation of radiological safety during two distinct time intervals. The first interval, commonly referred to as the preclosure period, deals with receipt of waste at the site, transfer into disposal containers, if needed, emplacement in the underground openings, monitoring and maintenance activities, backfill and closure of the underground openings, and decontamination and decommissioning of the surface facilities of the geologic repository. The preclosure period may extend from a few tens of years to as long as a few hundred of years, depending on repository design and societal norms regarding a final decision to permanently seal the repository. During the preclosure or operational period, performance confirmation studies are conducted to provide a basis for updating and reevaluating estimates of postclosure performance and, finally, to provide a basis for a closure decision. The postclosure period during which expected repository performance must meet certain standards may range from ten thousands years, as it does in the United States, to millions of years, as it does in some European nations. Waste handling operations in the preclosure period are to be evaluated in relation to their potential effect on workers, members of general public, and the general environment. During this period, releases of radioactivity are to be monitored and appropriate actions taken whenever established limits are approached or exceeded. Preclosure safety is highly dependent on facility design, operational hardware and automated systems, operational sequences, and reliability of humans involved in operations. Preclosure safety analyses conducted before operations begin play a major role in the design process, selection of equipment, and development of operational procedures. Because of the complexity, duration, and spatial scales of the operations, analyses are conducted using mathematical models implemented in computer codes

  16. Evaluation of repository safety

    International Nuclear Information System (INIS)

    Sagar, B.; Patrick, W.; Dasgupta, B.; Mohanty, S.

    2002-01-01

    The United States high-level waste program requires evaluation of radiological safety during two distinct time intervals. The first interval, commonly referred to as the preclosure period, deals with receipt of waste at the site, transfer into disposal containers, if needed, emplacement in the underground openings, monitoring and maintenance activities, backfill and closure of the underground openings, and decontamination and decommissioning of the surface facilities of the geologic repository. The preclosure period may extend from a few tens of years to as long as a few hundred of years, depending on repository design and societal norms regarding a final decision to permanently seal the repository. During the preclosure or operational period, performance confirmation studies are conducted to provide a basis for updating and reevaluating estimates of postclosure performance and, finally, to provide a basis for a closure decision. The postclosure period during which expected repository performance must meet certain standards may range from ten thousands years, as it does in the United States, to millions of years, as it does in some European nations. Waste handling operations in the preclosure period are to be evaluated in relation to their potential effect on workers, members of general public, and the general environment. During this period, releases of radioactivity are to be monitored and appropriate actions taken whenever established limits are approached or exceeded. Preclosure safety is highly dependent on facility design, operational hardware and automated systems, operational sequences, and reliability of humans involved in operations. Preclosure safety analyses conducted before operations begin play a major role in the design process, selection of equipment, and development of operational procedures. Because of the complexity, duration, and spatial scales of the operations, analyses are conducted using mathematical models implemented in computer codes

  17. [Blood transfusion and supply chain management safety].

    Science.gov (United States)

    Quaranta, Jean-François; Caldani, Cyril; Cabaud, Jean-Jacques; Chavarin, Patricia; Rochette-Eribon, Sandrine

    2015-02-01

    The level of safety attained in blood transfusion now makes this a discipline better managed care activities. This was achieved both by scientific advances and policy decisions regulating and supervising the activity, as well as by the quality system, which we recall that affects the entire organizational structure, responsibilities, procedures, processes and resources in place to achieve quality management. So, an effective quality system provides a framework within which activities are established, performed in a quality-focused way and continuously monitored to improve outcomes. This system quality has to irrigate all the actors of the transfusion, just as much the establishments of blood transfusion than the health establishments. Copyright © 2014 Elsevier Masson SAS. All rights reserved.

  18. Safety significance evaluation system

    International Nuclear Information System (INIS)

    Lew, B.S.; Yee, D.; Brewer, W.K.; Quattro, P.J.; Kirby, K.D.

    1991-01-01

    This paper reports that the Pacific Gas and Electric Company (PG and E), in cooperation with ABZ, Incorporated and Science Applications International Corporation (SAIC), investigated the use of artificial intelligence-based programming techniques to assist utility personnel in regulatory compliance problems. The result of this investigation is that artificial intelligence-based programming techniques can successfully be applied to this problem. To demonstrate this, a general methodology was developed and several prototype systems based on this methodology were developed. The prototypes address U.S. Nuclear Regulatory Commission (NRC) event reportability requirements, technical specification compliance based on plant equipment status, and quality assurance assistance. This collection of prototype modules is named the safety significance evaluation system

  19. PWR reload safety evaluation methodology

    International Nuclear Information System (INIS)

    Doshi, P.K.; Chapin, D.L.; Love, D.S.

    1993-01-01

    The current practice for WWER safety analysis is to prepare the plant Safety Analysis Report (SAR) for initial plant operation. However, the existing safety analysis is typically not evaluated for reload cycles to confirm that all safety limits are met. In addition, there is no systematic reanalysis or reevaluation of the safety analyses after there have been changes made to the plant. The Westinghouse process is discussed which is in contrast to this and in which the SAR conclusions are re-validated through evaluation and/or analysis of each reload cycle. (Z.S.)

  20. Objectives of safety evaluation

    International Nuclear Information System (INIS)

    Rosen, M.

    1980-01-01

    An examination of the safety aspects of exported nuclear power plants demonstrates that additional and somewhat special considerations exist for these plants. In view of this and the generally small regulatory staffs of importing coutnries, suggestions are given for measures which should be taken by various organizations involved in the export and import of nuclear power facilities to raise the level of the very essential safety assessment. (orig.)

  1. Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion.

    Science.gov (United States)

    Nkohkwo, Asa'ah; Agbor, Gabriel; Asongalem, Emmanuel; Tagny, Claude; Asonganyi, Tazoacha

    2016-01-01

    Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region. This review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region. The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinicians, scientists and professional bodies in the region, including the World Health Organization's Regional Office for Africa, to examine the suitability of PRT for improving the safety of whole blood transfusion, a prevalent transfusion format in the region. Existing literature suggests that combining PRT with current blood safety measures (such as serology) would improve the safety and adequacy of the blood supply for transfusions in sub-Saharan Africa. This was echoed by the findings of the stakeholder meetings. Following a detailed appraisal of two leading PRT systems, the Mirasol ® PRT System and the Cerus S-303 System, we suggest that companies conduct comprehensive toxicological evaluation of the agents used for PRT and publish this in the scientific literature. We also recommend that the safety and efficacy of these technologies should be established in a randomised clinical trial conducted in sub-Saharan Africa.

  2. HBOC-201 as an alternative to blood transfusion: efficacy and safety evaluation in a multicenter phase III trial in elective orthopedic surgery.

    Science.gov (United States)

    Jahr, Jonathan S; Mackenzie, Colin; Pearce, L Bruce; Pitman, Arkadiy; Greenburg, A Gerson

    2008-06-01

    The ability of hemoglobin based oxygen carrier-201 (HBOC-201) to safely reduce and/or eliminate perioperative transfusion was studied in orthopedic surgery patients. A randomized, single-blind, packed red blood cell (PRBC)-controlled, parallel-group multicenter study was conducted. Six hundred eighty-eight patients were randomized to treatment with HBOC-201 (H, n = 350) or PRBC (R, n = 338) at the first transfusion decision. Primary endpoints were transfusion avoidance and blinded assessment [Mann-Whitney estimator (MW)] of safety noninferiority. Groups were compared directly and by paired/matching group analyses predicated on a prospectively defined dichotomy [treatment success (HH) vs. failure (HR)] in the H arm and an equivalently defined dichotomy [3 (R3+) units PRBC] in the R arm, based on need (moderate vs. high) for additional oxygen carrying capacity. A total of 59.4% of patients in the H arm avoided PRBC transfusion. Adverse events (8.47 vs. 5.88), and serious adverse events (SAEs) (0.35 vs. 0.25) per patient were higher in the H versus R arms (p 80 years), volume overload and undertreatment contributed to this imbalance. HBOC-201 eliminated transfusion in the majority of subjects. The between arms (H vs. R) safety analysis was unfavorable and likely related to patient age, volume overload, and undertreatment and was isolated to patients that could not be managed by HBOC-201 alone. However, patients transfusion when treated with up to 10 units of HBOC-201.

  3. Experiment to evaluate software safety

    International Nuclear Information System (INIS)

    Soubies, B.; Henry, J.Y.

    1994-01-01

    The process of licensing nuclear power plants for operation consists of mandatory steps featuring detailed examination of the instrumentation and control system by the safety authorities, including softwares. The criticality of these softwares obliges the manufacturer to develop in accordance with the IEC 880 standard 'Computer software in nuclear power plant safety systems' issued by the International Electronic Commission. The evaluation approach, a two-stage assessment is described in detail. In this context, the IPSN (Institute of Protection and Nuclear Safety), the technical support body of the safety authority uses the MALPAS tool to analyse the quality of the programs. (R.P.). 4 refs

  4. The infectious disease blood safety risk of Australian hemochromatosis donations.

    Science.gov (United States)

    Hoad, Veronica; Bentley, Peter; Bell, Barbara; Pathak, Praveen; Chan, Hiu Tat; Keller, Anthony

    2016-12-01

    It has been suggested that blood donors with hereditary hemochromatosis may pose an increased infectious disease risk and adversely affect recipient outcomes. This study compares the infectious disease risk of whole blood (WB) donors enrolled as therapeutic (T) donors to voluntary WB donors to evaluate the safety of blood products provided by the T donors. This was a retrospective cohort study of all WB donations at the Australian Red Cross Blood Service who donated between January 1, 2011, and December 31, 2013, comparing a yearly mean of 11,789 T donors with 107,773 total donations and a yearly mean of 468,889 voluntary WB donors with 2,584,705 total donations. We compared postdonation notification of infectious illnesses, bacterial contamination screening results, and positive tests for blood borne viruses in T and WB donors. Rates of transfusion-transmissible infections in donations destined for component manufacture were significantly lower in therapeutic donations compared to voluntary donations (8.4 vs. 21.6 per 100,000 donations). Bacterial contamination (43.0 vs. 45.9 per 100,000 donations) and postdonation illness reporting (136.2 vs. 110.8 per 100,000 donations) were similar in both cohorts. The Australian therapeutic venisection program enables T donors to provide a safe and acceptable source of donated WB that has a low infectious disease risk profile. © 2016 AABB.

  5. LNG Safety Assessment Evaluation Methods

    Energy Technology Data Exchange (ETDEWEB)

    Muna, Alice Baca [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); LaFleur, Angela Christine [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2015-05-01

    Sandia National Laboratories evaluated published safety assessment methods across a variety of industries including Liquefied Natural Gas (LNG), hydrogen, land and marine transportation, as well as the US Department of Defense (DOD). All the methods were evaluated for their potential applicability for use in the LNG railroad application. After reviewing the documents included in this report, as well as others not included because of repetition, the Department of Energy (DOE) Hydrogen Safety Plan Checklist is most suitable to be adapted to the LNG railroad application. This report was developed to survey industries related to rail transportation for methodologies and tools that can be used by the FRA to review and evaluate safety assessments submitted by the railroad industry as a part of their implementation plans for liquefied or compressed natural gas storage ( on-board or tender) and engine fueling delivery systems. The main sections of this report provide an overview of various methods found during this survey. In most cases, the reference document is quoted directly. The final section provides discussion and a recommendation for the most appropriate methodology that will allow efficient and consistent evaluations to be made. The DOE Hydrogen Safety Plan Checklist was then revised to adapt it as a methodology for the Federal Railroad Administration’s use in evaluating safety plans submitted by the railroad industry.

  6. Blood donor recruitment strategies and their impact on blood safety in Egypt.

    Science.gov (United States)

    Hussein, Eiman

    2014-02-01

    Because of the high incidence of HCV, blood safety presents a serious challenge in Egypt. Given the constrained economy which limits the implementation of nucleic acid amplification technology, proper recruitment of blood donors becomes of paramount importance. To evaluate the effectiveness of blood donor recruitment strategies, the seroprevalence of positive infectious markers among blood donors was studied. Donors' records covering the period from 2006-2012 were reviewed. Blood donations were screened for HCV antibodies, HBs antigen (HBsAg), HIV-1 and 2 and syphilis antibodies. Of 308,762 donors, 63.4% were voluntary donors (VD). VD of 2011-2012 were significantly younger than family replacement donors (RD) .The overall prevalences of HCV antibodies, HBsAg, HIV and syphilis antibodies were 4.3%, 1.22%, 0.07%, and 0.13%, respectively. All tested markers (except HIV) were significantly higher among RD, when compared to VD (P<0.0001). A consistent steady trend for decrease in HCV seropositivity was observed in RD and VD from 8.9% and 4.2% to 3.8% and 1.5%, respectively. A trend for decrease in HBsAg was demonstrated in VD from 1.2% to 0.53%. The decreasing trends in HCV antibody and HBs antigen is promising and may reflect the improved donor selection criteria. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Material & equipment, procurement & maintenance: Impact on blood safety.

    Science.gov (United States)

    Emmanuel, Jean C

    2010-01-01

    Blood Transfusion Safety is dependent on effectively organised and managed blood services, which have adequate financial resources, skilled manpower, appropriate infrastructure and quality management systems in place. 80% of the world's population has access to 20% of the supply blood products, of which little is consistently safe. HIV highlighted the importance of blood safety. The lack of effective blood services in low human development index (LHDI), developing countries, has lead to international funding and capacity building for more than three decades. The initial strategies focused on providing HIV testing reagents to prevention transmission, however this only addresses one part of blood safety. Blood safety is not only dependent on preventing HIV transmission. In many populations there are other infectious agents, which have a higher prevalence. Ensuring the correct blood is provided to the patient depends on: well managed services with effective leadership and adequate budgets; capacity building and retention of skilled experienced staff; availability of laboratory equipment, correctly maintained; blood cold chain systems; procedures for tendering, purchasing and ensuring an unbroken supply of reagents and consumables; and quality management systems. Barriers for simplified effective tendering, procurement and contracting require urgent attention and coordination of all funding organisations to ensure an unbroken supply of reagents. Copyright 2009. Published by Elsevier Ltd.

  8. Blood transfusion safety; current status and challenges in Nigeria

    Directory of Open Access Journals (Sweden)

    John C Aneke

    2017-01-01

    Full Text Available The attainment of blood transfusion safety in Nigeria (and probably the rest of Sub-Saharan Africa remains an uphill task due to a number of factors, ranging from shortage of blood, poor implementation of blood transfusion guidelines, infrastructural deficits to high prevalence of transfusion-transmissible infections (TTIs, particularly hepatitis and human immune deficiency viruses. We reviewed available data on blood transfusion practices and safety in Nigeria using the PubMed, PubMed Central, Google Scholar, and African Index Medicus search engines, through a combination of word and phrases relevant to the subject. The World Health Organization has been in the forefront of efforts to establish safe, available, and affordable blood transfusion services in most parts of Africa through encouraging adequate blood donor recruitment, donor blood testing, and collection as well developing strategies for the rational use of blood. Even though modest improvement has been recorded, particularly with regards to donor blood screening for common TTIs, considerable efforts are needed in the form of robust public enlightenment campaigns (on blood donation and continuous system improvement to drive the current transfusion practices in the country toward safety and self-sustenance.

  9. Safety evaluation of food flavorings

    International Nuclear Information System (INIS)

    Schrankel, Kenneth R.

    2004-01-01

    Food flavorings are an essential element in foods. Flavorings are a unique class of food ingredients and excluded from the legislative definition of a food additive because they are regulated by flavor legislation and not food additive legislation. Flavoring ingredients naturally present in foods, have simple chemical structures, low toxicity, and are used in very low levels in foods and beverages resulting in very low levels of human exposure or consumption. Today, the overwhelming regulatory trend is a positive list of flavoring substances, e.g. substances not listed are prohibited. Flavoring substances are added to the list following a safety evaluation based on the conditions of intended use by qualified experts. The basic principles for assessing the safety of flavoring ingredients will be discussed with emphasis on the safety evaluation of flavoring ingredients by the Food and Agriculture Organization (FAO) and World Health Organization (WHO) Joint Expert Committee on Food Additives (JECFA) and the US Flavor and Extract Manufacturers Expert Panel (FEXPAN). The main components of the JECFA evaluation process include chemical structure, human intake (exposure), metabolism to innocuous or harmless substances, and toxicity concerns consistent with JECFA principles. The Flavor and Extract Manufacturers Association (FEMA) evaluation is very similar to the JECFA procedure. Both the JECFA and FEMA evaluation procedures are widely recognized and the results are accepted by many countries. This implies that there is no need for developing countries to conduct their own toxicological assessment of flavoring ingredients unless it is an unique ingredient in one country, but it is helpful to survey intake or exposure assessment. The global safety program established by the International Organization of Flavor Industry (IOFI) resulting in one worldwide open positive list of flavoring substances will be reviewed

  10. Hepatitis B Virus Blood Screening: Need for Reappraisal of Blood Safety Measures?

    Directory of Open Access Journals (Sweden)

    Daniel Candotti

    2018-02-01

    Full Text Available Over the past decades, the risk of HBV transfusion–transmission has been steadily reduced through the recruitment of volunteer donors, the selection of donors based on risk-behavior evaluation, the development of increasingly more sensitive hepatitis B antigen (HBsAg assays, the use of hepatitis B core antibody (anti-HBc screening in some low-endemic countries, and the recent implementation of HBV nucleic acid testing (NAT. Despite this accumulation of blood safety measures, the desirable zero risk goal has yet to be achieved. The residual risk of HBV transfusion–transmission appears associated with the preseroconversion window period and occult HBV infection characterized by the absence of detectable HBsAg and extremely low levels of HBV DNA. Infected donations tested false-negative with serology and/or NAT still persist and derived blood components were shown to transmit the virus, although rarely. Questions regarding the apparent redundancy of some safety measures prompted debates on how to reduce the cost of HBV blood screening. In particular, accumulating data strongly suggests that HBsAg testing may add little, if any HBV risk reduction value when HBV NAT and anti-HBc screening also apply. Absence or minimal acceptable infectious risk needs to be assessed before considering discontinuing HBsAg. Nevertheless, HBsAg remains essential in high-endemic settings where anti-HBc testing cannot be implemented without compromising blood availability. HBV screening strategy should be decided according to local epidemiology, estimate of the infectious risk, and resources.

  11. Evaluation of periodic safety status analyses

    International Nuclear Information System (INIS)

    Faber, C.; Staub, G.

    1997-01-01

    In order to carry out the evaluation of safety status analyses by the safety assessor within the periodical safety reviews of nuclear power plants safety goal oriented requirements have been formulated together with complementary evaluation criteria. Their application in an inter-disciplinary coopertion covering the subject areas involved facilitates a complete safety goal oriented assessment of the plant status. The procedure is outlined briefly by an example for the safety goal 'reactivity control' for BWRs. (orig.) [de

  12. Blood products: optimal use, conservation, and safety.

    Science.gov (United States)

    Cone, J; Day, L J; Johnson, G K; Murray, D G; Nelson, C L

    1990-01-01

    A review of our experience in total joint arthroplasty revealed that the cell saver was not cost-effective in the case of routine primary hip or knee replacement. Its use should be restricted to cases of revision hip and knee surgery in which infection has been ruled out. Preoperative aspiration remains the most reliable method for accomplishing this. However, if the aspiration is negative and the intra-articular fluid obtained at the time of surgery is suspicious for infection, either in appearance or on Gram stain or cell count, it is best to abandon use of the cell saver. Predonation should be routine for all hip replacement cases unless there are specific contraindications. In general, there is good acceptance of this program by patients, although a few have specifically indicated they would prefer to run the risk of homologous transfusion. Two units available for primary replacement are more than ample. In cases of revisions, a first revision justifies a minimum of 3 units. For complex revision cases involving patients with three or more previous procedures on the hip, or those requiring significant bone resection or large segment grafting, the maximum possible number of units should be obtained. Autologous blood reinfusion should be done for essentially the same indications as homologous transfusion even though risks are sharply reduced. The local source for autologous collection will then follow its own specific protocol for the disposition of remaining units. In every case, the surgical technique should be careful and directed toward limiting intraoperative blood loss.

  13. Can a decentralized blood system ensure self-sufficiency and blood safety? The Lebanese experience.

    Science.gov (United States)

    Haddad, Antoine; Bou Assi, Tarek; Garraud, Olivier

    2017-08-01

    Lebanon has adopted a liberal economic system that also applies to healthcare procurement. There is no national Lebanese blood transfusion service and the blood supply is divided between a large number of licensed (45 per cent) and unlicensed (55 per cent) blood banks, many of them issuing a very limited number of blood components. All blood banks are hospital based and operate the entire transfusion chain, from collection to the release of blood units. Blood donation is voluntary and non-remunerated in 20-25 per cent of donations; it relies principally on replacement donations. Recently, Lebanon has faced political instability and war, and now welcomes an enormous number of refugees from neighboring countries at war. This has had an important impact on heath care and on the transfusion supply. We discuss the impact of the blood donation organization on the transfusion safety and ethics, to set the foundation for a more developed and safer transfusion programs.

  14. Xenotropic murine leukemia virus-related virus does not pose a risk to blood recipient safety.

    Science.gov (United States)

    Dodd, Roger Y; Hackett, John; Linnen, Jeffrey M; Dorsey, Kerri; Wu, Yanyun; Zou, Shimian; Qiu, Xiaoxing; Swanson, Priscilla; Schochetman, Gerald; Gao, Kui; Carrick, James M; Krysztof, David E; Stramer, Susan L

    2012-02-01

    When xenotropic murine leukemia virus-related virus (XMRV) was first reported in association with chronic fatigue syndrome, it was suggested that it might offer a risk to blood safety. Thus, the prevalence of the virus among blood donors and, if present, its transmissibility by transfusion need to be defined. Two populations of routine blood donor samples (1435 and 13,399) were obtained for prevalence evaluations; samples from a linked donor-recipient repository were also evaluated. Samples were tested for the presence of antibodies to XMRV-related recombinant antigens and/or for XMRV RNA, using validated, high-throughput systems. The presence of antibodies to XMRV could not be confirmed among a total of 17,249 blood donors or recipients (0%; 95% confidence interval [CI], 0%-0.017%); 1763 tested samples were nonreactive for XMRV RNA (0%; 95% CI, 0%-0.17%). Evidence of infection was absent from 109 recipients and 830 evaluable blood samples tested after transfusion of a total of 3741 blood components. XMRV and related murine leukemia virus (MLV) markers are not present among a large population of blood donors and evidence of transfusion transmission could not be detected. Thus, these viruses do not currently pose a threat to blood recipient safety and further actions relating to XMRV and MLV are not justified. © 2012 American Association of Blood Banks.

  15. Safety climate and attitude as evaluation measures of organizational safety.

    Science.gov (United States)

    Isla Díaz, R; Díaz Cabrera, D

    1997-09-01

    The main aim of this research is to develop a set of evaluation measures for safety attitudes and safety climate. Specifically it is intended: (a) to test the instruments; (b) to identify the essential dimensions of the safety climate in the airport ground handling companies; (c) to assess the quality of the differences in the safety climate for each company and its relation to the accident rate; (d) to analyse the relationship between attitudes and safety climate; and (e) to evaluate the influences of situational and personal factors on both safety climate and attitude. The study sample consisted of 166 subjects from three airport companies. Specifically, this research was centered on ground handling departments. The factor analysis of the safety climate instrument resulted in six factors which explained 69.8% of the total variance. We found significant differences in safety attitudes and climate in relation to type of enterprise.

  16. Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial.

    Science.gov (United States)

    Ruschitzka, Frank; Borer, Jeffrey S; Krum, Henry; Flammer, Andreas J; Yeomans, Neville D; Libby, Peter; Lüscher, Thomas F; Solomon, Daniel H; Husni, M Elaine; Graham, David Y; Davey, Deborah A; Wisniewski, Lisa M; Menon, Venu; Fayyad, Rana; Beckerman, Bruce; Iorga, Dinu; Lincoff, A Michael; Nissen, Steven E

    2017-11-21

    Non-steroidal anti-inflammatory drugs (NSAIDs), both non-selective and selective cyclooxygenase-2 (COX-2) inhibitors, are among the most widely prescribed drugs worldwide, but associate with increased blood pressure (BP) and adverse cardiovascular (CV) events. PRECISION-ABPM, a substudy of PRECISION was conducted at 60 sites, to determine BP effects of the selective COX-2 inhibitor celecoxib vs. the non-selective NSAIDs naproxen and ibuprofen. In this double-blind, randomized, multicentre non-inferiority CV-safety trial, 444 patients (mean age 62 ± 10 years, 54% female) with osteoarthritis (92%) or rheumatoid arthritis (8%) and evidence of or at increased risk for coronary artery disease received celecoxib (100-200 mg bid), ibuprofen (600-800 mg tid), or naproxen (375-500 mg bid) with matching placebos in a 1: 1: 1 allocation, to assess the effect on 24-h ambulatory BP after 4 months. The change in mean 24-h systolic BP (SBP) in celecoxib, ibuprofen and naproxen-treated patients was -0.3 mmHg [95% confidence interval (CI), -2.25, 1.74], 3.7 (95% CI, 1.72, 5.58) and 1.6 mmHg (95% CI, -0.40, 3.57), respectively. These changes resulted in a difference of - 3.9 mmHg (P = 0.0009) between celecoxib and ibuprofen, of - 1.8 mmHg (P = 0.12) between celecoxib and naproxen, and of - 2.1 mmHg (P = 0.08) between naproxen and ibuprofen. The percentage of patients with normal baseline BP who developed hypertension (mean 24-h SBP ≥ 130 and/or diastolic BP ≥ 80 mmHg) was 23.2% for ibuprofen, 19.0% for naproxen, and 10.3% for celecoxib (odds ratio 0.39, P = 0.004 and odds ratio 0.49, P = 0.03 vs. ibuprofen and naproxen, respectively). In PRECISION-ABPM, allocation to the non-selective NSAID ibuprofen, compared with the COX-2 selective inhibitor celecoxib was associated with a significant increase of SBP, and a higher incidence of new-onset hypertension. gov number NCT00346216. Published on behalf of the European

  17. The status of blood safety in ECO member states

    Science.gov (United States)

    Seighali, Fariba; Hosseini Divkolaye, Nasim S.; Koohi, Ebrahim; Pourfathollah, Ali A.; Rahmani, Ahmad M.

    2015-01-01

    Background Access to the information concerning blood safety is essential for managing problems and overcoming the challenges that are faced in any given region. Information on the availability and safety of blood in countries of the Economic Cooperation Organisation (ECO) is largely lacking. To address this problem, the Iranian Blood Transfusion Organisation, in collaboration with other ECO member states, initiated a research project in 2009 to collect, analyse and compare statistics on blood safety in the region. Materials and methods A modified and summarised version of the Global Database on Blood Safety (GDBS) questionnaire was used to collect data. The questionnaire was sent to all ten countries in the ECO region. The heads of the national transfusion services or focal points were requested to complete the form. Related literature and websites were also reviewed. Results Only three countries (Afghanistan, Iran and Turkey) completed the questionnaire, while other countries provided their available data on some parts of the questionnaire. The number of donations per year varied from 5 to 27/1,000 population. The rate of donors positive for human immunodeficiency virus ranged from 0.003% to 0.2%. The rate of donors positive for hepatitis C virus antibody varied from 0.05% to 3.9% while that of hepatitis B virus surface antigen ranged from 0.15% to 3.91% respectively. Discussion There is very clear diversity in blood transfusion services among ECO member states. Most countries in the region do not have a data-recording system. It is generally estimated that the need for blood is much higher than the supply in this region. Deficiencies in donor screening and a high prevalence of transfusion-transmitted infections are other important challenges. PMID:26192779

  18. Transfusion safety: is this the business of blood centers?

    Science.gov (United States)

    Slapak, Colleen; Fredrich, Nanci; Wagner, Jeffrey

    2011-12-01

    ATSO is in a unique position to break down organizational silos between hospitals and blood centers through the development of a collaborative relationship between the two entities. Use of the TSO as blood center staff centralizes the role into a consultative position thereby retaining the independence of the hospitals. The TSO position then becomes a value-added service offered by the blood center designed to supplement processes within the hospital.Whether the TSO is based in the hospital or the blood center, improvements are gained through appropriate utilization of blood components, reductions in hospital costs, ongoing education of hospital staff involved in transfusion practice, and increased availability of blood products within the community. Implementation and standardization of best practice processes for ordering and administration of blood products developed by TSOs leads to improved patient outcomes. As a liaison between hospitals and blood centers, the TSO integrates the mutual goal of transfusion safety: the provision of the safest blood product to the right patient at the right time for the right reason.

  19. The potential of viral metagenomics in blood transfusion safety.

    Science.gov (United States)

    Sauvage, V; Gomez, J; Boizeau, L; Laperche, S

    2017-09-01

    Thanks to the significant advent of high throughput sequencing in the last ten years, it is now possible via metagenomics to define the spectrum of the microbial sequences present in human blood samples. Therefore, metagenomics sequencing appears as a promising approach for the identification and global surveillance of new, emerging and/or unexpected viruses that could impair blood transfusion safety. However, despite considerable advantages compared to the traditional methods of pathogen identification, this non-targeted approach presents several drawbacks including a lack of sensitivity and sequence contaminant issues. With further improvements, especially to increase sensitivity, metagenomics sequencing should become in a near future an additional diagnostic tool in infectious disease field and especially in blood transfusion safety. Copyright © 2017 Elsevier Masson SAS. All rights reserved.

  20. 10CFR50.59 safety evaluations

    International Nuclear Information System (INIS)

    Grime, L.; Page, E.

    1987-01-01

    As a plant changes from the design phase to the operational phase, new regulations and standards apply. One such regulation is 10CFR50.59 on safety evaluations. Once an operating license is issued, it is mandatory to submit all applicable changes, tests, and experiments to the safety evaluation process. As preparation for this transition, Detroit Edison had procedures in place and conducted personnel training. Reviews of the safety engineering were conducted by the on-site review board. The off-site board delegated detailed reviews of most safety evaluations to the independent safety evaluation group (ISEG). The on-site group review included presentation of complete design packages by engineers. The ISEG and off-site review group's activity focused on safety evaluation. This paper addresses industry trends that were studied, Detroit Edison's recent actions, and industry issues related to 10CFR50.59 safety evaluations

  1. Health economics of blood transfusion safety - focus on sub-Saharan Africa

    NARCIS (Netherlands)

    van Hulst, Marinus; Smit Sibinga, Cees Th. Smit; Postma, Maarten J.

    Background and objectives. Health economics provides a standardised methodology for valid comparisons of interventions in different fields of health care. This review discusses the health economic evaluations of strategies to enhance blood product safety in sub-Saharan Africa Methods. We reviewed

  2. Automated nucleic acid amplification testing in blood banks: An additional layer of blood safety

    Directory of Open Access Journals (Sweden)

    Pragati Chigurupati

    2015-01-01

    Full Text Available Context: A total of 30 million blood components are transfused each year in India. Blood safety thus becomes a top priority, especially with a population of around 1.23 billion and a high prevalence rate of human immunodeficiency virus (HIV, hepatitis B virus (HBV and hepatitis C virus (HCV in general population. Nucleic acid amplification testing (NAT in blood donor screening has been implemented in many developed countries to reduce the risk of transfusion-transmitted viral infections (TTIs. NAT takes care of the dynamics of window period of viruses and offers the safest blood pack for donation. Aims: The aim of this study is to show the value of NAT in blood screening. Settings and Design: Dhanavantari Blood Bank, Rajahmundry, Andhra Pradesh, India. Subjects and Methods: Over a period of 1 year from January 2012 to December 2012, a total number of 15,000 blood donor samples were subjected to tests for HIV, HBV, and HCV by enzyme-linked immunosorbent assay (ELISA method and 8000 ELISA nonreactive samples were subjected for NAT using multiplex polymerase chain reaction technology. Results: Of the 15,000 donors tested, 525 were seroreactive. In 8000 ELISA negative blood samples subjected to NAT, 4 donor samples were reactive for HBV. The NAT yield was 1 in 2000. Conclusions: NAT could detect HIV, HBV, and HCV cases in blood donor samples those were undetected by serological tests. NAT could interdict 2500 infectious donations among our approximate 5 million annual blood donations.

  3. Criticality safety evaluation in Tokai Reprocessing Plant

    International Nuclear Information System (INIS)

    Shirai, Nobutoshi; Nakajima, Masayoshi; Takaya, Akikazu; Ohnuma, Hideyuki; Shirouzu, Hidetomo; Hayashi, Shinichiro; Yoshikawa, Koji; Suto, Toshiyuki

    2000-04-01

    Criticality limits for equipments in Tokai Reprocessing Plant which handle fissile material solution and are under shape and dimension control were reevaluated based on the guideline No.10 'Criticality safety of single unit' in the regulatory guide for reprocessing plant safety. This report presents criticality safety evaluation of each equipment as single unit. Criticality safety of multiple units in a cell or a room was also evaluated. The evaluated equipments were ones in dissolution, separation, purification, denitration, Pu product storage, and Pu conversion processes. As a result, it was reconfirmed that the equipments were safe enough from a view point of criticality safety of single unit and multiple units. (author)

  4. Evaluating safety management system implementation

    International Nuclear Information System (INIS)

    Preuss, M.

    2009-01-01

    Canada is committed to not only maintaining, but also improving upon our record of having one of the safest aviation systems in the world. The development, implementation and maintenance of safety management systems is a significant step towards improving safety performance. Canada is considered a world leader in this area and we are fully engaged in implementation. By integrating risk management systems and business practices, the aviation industry stands to gain better safety performance with less regulatory intervention. These are important steps towards improving safety and enhancing the public's confidence in the safety of Canada's aviation system. (author)

  5. Safety evaluation of advance street name signs

    Science.gov (United States)

    2009-06-01

    The Federal Highway Administration (FHWA) organized a pooled fund study of 26 States to evaluate low-cost safety strategies as part of its strategic highway safety effort. The objective of the pooled fund study was to estimate the safety effectivenes...

  6. Status of Nuclear Safety evaluation in China

    International Nuclear Information System (INIS)

    Tian Jiashu

    1999-01-01

    Chinese nuclear safety management and control follows international practice, the regulations are mainly from IAEA with the Chinese condition. The regulatory body is National Nuclear Safety Administration (NNSA). The nuclear safety management, surveillance, safety review and evaluation are guided by NNSA with technical support by several units. Beijing Review Center of Nuclear Safety is one of these units, which was founded in 1987 within Beijing Institute of nuclear Engineering (BINE), co-directed by NNSA and BINE, it is the first technical support team to NNSA. Most of the safety reviews and evaluations of Chinese nuclear installations has been finished by this unit. It is described briefly in this paper that the NNSA's main function and organization, regulations on the nuclear safety, procedure of application and issuing of license, the main activities performed by Beijing Review Center of Nuclear Safety, the situation of severe accident analyses in China, etc. (author)

  7. MC225, a Novel Probe for P-glycoprotein PET Imaging at the Blood-brain Barrier: In Vitro Cardiovascular Safety Evaluation.

    Science.gov (United States)

    Fusi, Fabio; Durante, Miriam; Gorelli, Beatrice; Perrone, Maria Grazia; Colabufo, Nicola Antonio; Saponara, Simona

    2017-12-01

    The P-glycoprotein (P-gp) substrate MC225, at concentrations ≤10 nM, is a valuable radiotracer for positron emission tomography imaging of P-gp function in rats and mice. The aim of this study was to evaluate its potential toxic hazard toward the cardiovascular system through an in-depth analysis of its effects on rat aorta rings, on CaV1.2 channel current (ICa1.2) of A7r5 cells and on Langendorff-perfused rat heart. In aortic rings, MC225 relaxed phenylephrine-induced contraction in a concentration-dependent and endothelium-independent manner, with an IC50 value of about 1 μM. At concentrations ≥3 μM, it antagonized the response to cumulative concentrations of K. MC225, 1 and 10 μM, inhibited ICa1.2 by 15% and 31%, respectively, without affecting either current activation or inactivation kinetics. In Langendorff-perfused rat hearts, only 10 μM MC225 significantly decreased left ventricular pressure and increased coronary perfusion pressure while reducing heart rate and prolonging the cardiac cycle length as well as the atrioventricular conduction time (PQ interval) on the electrocardiogram. Lower concentrations of the drug were ineffective. These findings demonstrate that MC225-induced cardiovascular effects took place at concentrations that are at least 2 orders of magnitude higher than those allowing in vivo measurement of P-gp function. Therefore, MC225 represents a promising positron emission tomography tool for in vivo straightforward P-gp quantification.

  8. Evaluation on safety issues of SMART

    International Nuclear Information System (INIS)

    Kim, W. S.; Seol, K. W.; Yoon, Y. K.; Lee, J. H.

    2001-01-01

    Safety issues on the SMART were evaluated in the light of the compliance with the Ministerial Ordinance of Technical Requirements applying to Nuclear Installations, which was recently revised. Evaluation concludes that regulatory requirements associated with following items have to be developed as the licensing criteria for the SMART: (1) proving the safety of design or materials different form existing reactors; (2) coping with beyond design basis accidents; (3) rulemaking on the safety of reactor safeguard vessel ; (4) ensuring integrity of steam generator tubes; and (5) classifying equipment based on their safety significance. Appropriate actions including implementation of new requirements under development should be taken for safety issues such as diversity of reactivity control and in-service inspection of steam generator tubes that are not complied with the current Technical Requirements. Safety level of the SMART design will be evaluated further by the more detailed assessment according to the Technical Requirements, and additional safety issues will be identified and resolved, if it necessary

  9. Whole blood pathogen reduction technology and blood safety in sub-Saharan Africa: A systematic review with regional discussion

    OpenAIRE

    Nkohkwo, Asa?ah; Agbor, Gabriel; Asongalem, Emmanuel; Tagny, Claude; Asonganyi, Tazoacha

    2016-01-01

    Background: Despite vast improvements in transfusion services in sub-Saharan Africa over the last decade, there remain serious concerns on the safety and adequacy of the blood supply across the region. Objective: This review paper ascertains the role of pathogen reduction technology (PRT) in improving blood safety and supply adequacy in the region. Method: The state of blood safety in sub-Saharan Africa was reviewed. Meetings, seminars and correspondence were undertaken with key clinic...

  10. [Blood conservation effect and safety of shed mediastinal blood autotransfusion after cardiac surgery].

    Science.gov (United States)

    Komiya, T; Ban, K; Yamazaki, K; Date, O; Nakamura, T; Kanzaki, Y

    1998-10-01

    Autotransfusion of shed mediastinal blood after cardiac surgery has been used to reduce risks related to homologous blood transfusions. To document the efficacy and safety of autotransfusion, we compared clinical findings of 80 patients receiving shed mediastinal blood (autotransfusion group) with those of the control group of 52 patients. The amount of the autotransfusion was limited to 800 ml, given the potentially harmful effects of shed blood transfusion. The mean transfused shed volume was 314 +/- 236 ml (S.D.). The serum levels of FDP-E, D-dimer and TAT after autotransfusion were higher in the autotransfusion group than in the control group (p = 0.01, p = 0.0004, p = 0.001, respectively). However, postoperative blood loss and the rate of reexploration for bleeding were similar in the two groups. The patients receiving blood products were fewer in the autotransfusion group than those in the control group (21% vs 44%; p = 0.005). Autotransfusion did not increase postoperative complications, including infection. Thus, although autotransfusion of mediastinal shed blood has the potential to affect hemostasis, unless the amount of autotransfusion exceeds 800 ml, it appears that this method is clinically safe and effective as a mean of blood conservation.

  11. TAPS safety evaluation criteria for reload fueling

    International Nuclear Information System (INIS)

    Mahendra Nath; Veeraraghavan, N.

    1976-01-01

    To improve operating performance of Tarapur reactors, several proposals are under consideration such as core expansion, change-over to an improved fuel design with lower heat rating, extension of fuel cycle lengths etc., which have a bearing on overall plant operating characteristics and reactor safety. For evaluating safety implications of the various proposals, it is necessary to formulate safety evaluation criteria for reload fuelling. Salient features of these criteria are discussed. (author)

  12. Parameters Evaluation of PLC Dependability and Safety

    Directory of Open Access Journals (Sweden)

    Juraj Zdansky

    2006-01-01

    Full Text Available This paper is focused on evaluation of dependability and safety parameters of PLC (Programmable Logic Controller. Achievement of requested level of these parameters is an application assumption for using PLC in control of safety critical processes. Evaluation of these parameters can be made on the base of suitable model and it can be influenced by system architecture when necessary.

  13. SAFETY CONSIDERATIONS WITH BLOOD FLOW RESTRICTED RESISTANCE TRAINING

    Directory of Open Access Journals (Sweden)

    Alan Kacin

    2015-11-01

    Full Text Available Blood flow restricted resistance (BFRR training with pneumatic tourniquet has been suggested as an alternative for conventional weight training due to the proven benefits for muscle strength and hypertrophy using relatively low resistance, hence reducing the mechanical stress across a joint. As such, it has become an important part of rehabilitation programs used in either injured or operated athletes. Despite a general consensus on effectiveness of BFRR training for muscle conditioning, there are several uncertainties regarding the interplay of various extrinsic and intrinsic factors on its safety and efficiency, which are being reviewed from a clinical perspective. Among extrinsic factors tourniquet cuff pressure, size and shape have been identified as key for safety and efficiency. Among intrinsic factors, limb anthropometrics, patient history and presence of cardiac, vascular, metabolic or peripheral neurologic conditions have been recognized as most important. Though there are a few potential safety concerns connected to BFRR training, the following have been identified as the most probable and health-hazardous: (a mechanical injury to the skin, muscle, and peripheral nerves, (b venous thrombosis due to vascular damage and disturbed hemodynamics and (c augmented arterial blood pressure responses due to combined high body exertion and increased peripheral vascular resistance. Based on reviewed literature and authors’ personal experience with the use of BFRR training in injured athletes, some guidelines for its safe application are outlined. Also, a comprehensive risk assessment tool for screening of subjects prior to their inclusion in a BFRR training program is being introduced.

  14. Safety evaluations required in the safety regulations for Monju and the validity confirmation of safety evaluation methods

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The purposes of this study are to perform the safety evaluations of the fast breeder reactor 'Monju' and to confirm the validity of the safety evaluation methods. In JFY 2012, the following results were obtained. As for the development of safety evaluation methods needed in the safety examination achieved for the reactor establishment permission, development of the analysis codes, such as a core damage analysis code, were carried out according to the plan. As for the development of the safety evaluation method needed for the risk informed safety regulation, the quantification technique of the event tree using the Continuous Markov chain Monte Carlo method (CMMC method) were studied. (author)

  15. Drug safety evaluation of defibrotide.

    Science.gov (United States)

    Richardson, Paul G; Corbacioglu, Selim; Ho, Vincent Trien-Vinh; Kernan, Nancy A; Lehmann, Leslie; Maguire, Craig; Maglio, Michelle; Hoyle, Margaret; Sardella, Marco; Giralt, Sergio; Holler, Ernst; Carreras, Enric; Niederwieser, Dietger; Soiffer, Robert

    2013-01-01

    Hepatic veno-occlusive disease (VOD), also known as sinusoidal obstruction syndrome (SOS), is a potentially life-threatening complication of chemotherapeutic conditioning used in preparation for hematopoietic stem-cell transplantation (SCT). Defibrotide (DF) has been shown in Phase II and III trials to improve complete response in patients with severe VOD (sVOD). None of the articles, to date, provide a comprehensive review of the safety of DF in VOD and/or a range of other conditions. This article reviews current clinical findings on DF, primarily in terms of safety for use in treatment and prophylaxis of VOD, and relevant safety data for its use in other diseases. The literature review was conducted using a PubMed search with the fixed term 'defibrotide' in combination with ≥ 1 of 'safety', 'veno-occlusive disease' (with and without 'treatment', 'prevention'), 'oncology', 'myeloma', 'microangiopathy', 'anti-thrombotic' and 'peripheral vascular disorder'. Related articles from the EBMT and ASH conference websites were also included. DF was well tolerated in majority of the studies. The safety profile of DF is largely favourable with toxicities comparable to control populations in the setting of SCT complicated by sVOD.

  16. Approach to uncertainty evaluation for safety analysis

    International Nuclear Information System (INIS)

    Ogura, Katsunori

    2005-01-01

    Nuclear power plant safety used to be verified and confirmed through accident simulations using computer codes generally because it is very difficult to perform integrated experiments or tests for the verification and validation of the plant safety due to radioactive consequence, cost, and scaling to the actual plant. Traditionally the plant safety had been secured owing to the sufficient safety margin through the conservative assumptions and models to be applied to those simulations. Meanwhile the best-estimate analysis based on the realistic assumptions and models in support of the accumulated insights could be performed recently, inducing the reduction of safety margin in the analysis results and the increase of necessity to evaluate the reliability or uncertainty of the analysis results. This paper introduces an approach to evaluate the uncertainty of accident simulation and its results. (Note: This research had been done not in the Japan Nuclear Energy Safety Organization but in the Tokyo Institute of Technology.) (author)

  17. Site evaluation for nuclear installations. Safety requirements

    International Nuclear Information System (INIS)

    2003-01-01

    This Safety Requirements publication supersedes the Code on the Safety of Nuclear Power Plants: Siting, which was issued in 1988 as Safety Series No. 50-C-S (Rev. 1). It takes account of developments relating to site evaluations for nuclear installations since the Code on Siting was last revised. These developments include the issuing of the Safety Fundamentals publication on The Safety of Nuclear Installations, and the revision of various safety standards and other publications relating to safety. Requirements for site evaluation are intended to ensure adequate protection of site personnel, the public and the environment from the effects of ionizing radiation arising from nuclear installations. It is recognized that there are steady advances in technology and scientific knowledge, in nuclear safety and in what is considered adequate protection. Safety requirements change with these advances and this publication reflects the present consensus among States. This Safety Requirements publication was prepared under the IAEA programme on safety standards for nuclear installations. It establishes requirements and provides criteria for ensuring safety in site evaluation for nuclear installations. The Safety Guides on site evaluation listed in the references provide recommendations on how to meet the requirements established in this Safety Requirements publication. The objective of this publication is to establish the requirements for the elements of a site evaluation for a nuclear installation so as to characterize fully the site specific conditions pertinent to the safety of a nuclear installation. The purpose is to establish requirements for criteria, to be applied as appropriate to site and site-installation interaction in operational states and accident conditions, including those that could lead to emergency measures for: (a) Defining the extent of information on a proposed site to be presented by the applicant; (b) Evaluating a proposed site to ensure that the site

  18. Evaluation of red blood cell stability during immersion blood warming

    African Journals Online (AJOL)

    Introduction: The practice of warming blood for transfusion by immersion into a waterbath has been investigated. Objective: To find the maximum waterbath temperature at which blood can be heated effectively without effecting the red blood cell functional and structural integrity. Method: Blood, three days after donation ...

  19. Comparative evaluation of trace elements in blood

    International Nuclear Information System (INIS)

    Goeij, J.J.M. de; Tjioe, P.S.; Pries, C.; Zwiers, J.H.L.

    1976-01-01

    The Interuniversitair Reactor Instituut and the Centraal Laboratorium TNO have carried out a common investigation on neutron-activation-analytical procedures for the determination of trace elements in blood. A comparative evaluation of five methods, destructive as well as non-destructive, is given. The sensitivity and reproducibility of the procedures are discussed. By combining some of the methods it is possible, starting with 1 ml blood, to give quantitative information on 14 important trace elements: antimony, arsenic, bromine, cadmium, cobalt, gold, copper, mercury, molybdenum, nickel, rubidium, selenium, iron and zinc. The methods have also been applied to sodium, chromium and potassium

  20. 78 FR 28848 - Meeting of the Advisory Committee on Blood and Tissue Safety and Availability

    Science.gov (United States)

    2013-05-16

    ... health, ethical and legal issues related to the safety of blood, blood products, and tissues; (4) the impact of various economic factors (e.g., product cost and supply) on safety and availability of blood... coordinated system to manage tissue supplies and distributions during a disaster does not exist. Past...

  1. 75 FR 28619 - Meeting of the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2010-05-21

    ... public health parameters around safety and availability of the blood supply and blood products, (2) broad public health, ethical and legal issues related to transfusion and transplantation safety, and (3) the implications for safety and the availability of various economic factors affecting product cost and supply...

  2. 76 FR 26300 - Meeting of the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2011-05-06

    ... around safety and availability of the blood supply and blood products, (2) broad public health, ethical... safety and availability of various economic factors affecting product cost and supply. In keeping with... reactions on the practices, safety, quality, efficacy, epidemiology and ethics of donations and...

  3. Experiment on safety software evaluation

    International Nuclear Information System (INIS)

    Soubies, B.; Henry, J.Y.

    1994-06-01

    The licensing procedures process of nuclear plants includes compulsory steps which bring about a thorough exam of the commands control system. In this context the IPSN uses a tool called MALPAS to carry out an analysis of the quality of the software involved in safety control. The IPSN also try to obtain the automation of the generation of test games necessary for dynamical analysis. The MALPAS tool puts forward the particularities of programing which can influence the testability and the upholding of the studied software. (TEC). 4 refs

  4. Researches on nuclear criticality safety evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Okuno, Hiroshi; Suyama, Kenya; Nomura, Yasushi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-10-01

    For criticality safety evaluation of burnup fuel, the general-purpose burnup calculation code, SWAT, was revised, and its precision was confirmed through comparison with other results from OECD/NEA's burnup credit benchmarks. Effect by replacing the evaluated nuclear data from JENDL-3.2 to ENDF/B-VI and JEF-2.2 was also studied. Correction factors were derived for conservative evaluation of nuclide concentrations obtained with the simplified burnup code ORIGEN2.1. The critical masses of curium were calculated and evaluated for nuclear criticality safety management of minor actinides. (author)

  5. Researches on nuclear criticality safety evaluation

    International Nuclear Information System (INIS)

    Okuno, Hiroshi; Suyama, Kenya; Nomura, Yasushi

    2003-01-01

    For criticality safety evaluation of burnup fuel, the general-purpose burnup calculation code, SWAT, was revised, and its precision was confirmed through comparison with other results from OECD/NEA's burnup credit benchmarks. Effect by replacing the evaluated nuclear data from JENDL-3.2 to ENDF/B-VI and JEF-2.2 was also studied. Correction factors were derived for conservative evaluation of nuclide concentrations obtained with the simplified burnup code ORIGEN2.1. The critical masses of curium were calculated and evaluated for nuclear criticality safety management of minor actinides. (author)

  6. Health economics of blood transfusion safety--focus on sub-Saharan Africa.

    Science.gov (United States)

    van Hulst, Marinus; Smit Sibinga, Cees Th; Postma, Maarten J

    2010-01-01

    Health economics provides a standardised methodology for valid comparisons of interventions in different fields of health care. This review discusses the health economic evaluations of strategies to enhance blood product safety in sub-Saharan Africa. We reviewed health economic methodology with special reference to cost-effectiveness analysis. We searched the literature for cost-effectiveness in blood product safety in sub-Saharan Africa. HIV-antibody screening in different settings in sub-Saharan Africa showed health gains and saved costs. Except for adding HIV-p24 screening, adding other tests such as nucleic acid amplification testing (NAT) to HIV-antibody screening displayed incremental cost-effectiveness ratios greater than the WHO/World Bank specified threshold for cost-effectiveness. The addition of HIV-p24 in combination with HCV antibody/antigen screening and multiplex (HBV, HCV and HIV) NAT in pools of 24 may also be cost-effective options for Ghana. From a health economic viewpoint, HIV-antibody screening should always be implemented in sub-Saharan Africa. The addition of HIV-p24 antigen screening, in combination with HCV antibody/antigen screening and multiplex (HBV, HCV and HIV) NAT in pools of 24 may be feasible options for Ghana. Suggestions for future health economic evaluations of blood transfusion safety interventions in sub-Saharan Africa are: mis-transfusion, laboratory quality and donor management. Copyright 2009 The International Association for Biologicals. Published by Elsevier Ltd. All rights reserved.

  7. Prospective safety performance evaluation on construction sites.

    Science.gov (United States)

    Wu, Xianguo; Liu, Qian; Zhang, Limao; Skibniewski, Miroslaw J; Wang, Yanhong

    2015-05-01

    This paper presents a systematic Structural Equation Modeling (SEM) based approach for Prospective Safety Performance Evaluation (PSPE) on construction sites, with causal relationships and interactions between enablers and the goals of PSPE taken into account. According to a sample of 450 valid questionnaire surveys from 30 Chinese construction enterprises, a SEM model with 26 items included for PSPE in the context of Chinese construction industry is established and then verified through the goodness-of-fit test. Three typical types of construction enterprises, namely the state-owned enterprise, private enterprise and Sino-foreign joint venture, are selected as samples to measure the level of safety performance given the enterprise scale, ownership and business strategy are different. Results provide a full understanding of safety performance practice in the construction industry, and indicate that the level of overall safety performance situation on working sites is rated at least a level of III (Fair) or above. This phenomenon can be explained that the construction industry has gradually matured with the norms, and construction enterprises should improve the level of safety performance as not to be eliminated from the government-led construction industry. The differences existing in the safety performance practice regarding different construction enterprise categories are compared and analyzed according to evaluation results. This research provides insights into cause-effect relationships among safety performance factors and goals, which, in turn, can facilitate the improvement of high safety performance in the construction industry. Copyright © 2015 Elsevier Ltd. All rights reserved.

  8. Plutonium Finishing Plant safety evaluation report

    International Nuclear Information System (INIS)

    1995-01-01

    The Plutonium Finishing Plant (PFP) previously known as the Plutonium Process and Storage Facility, or Z-Plant, was built and put into operation in 1949. Since 1949 PFP has been used for various processing missions, including plutonium purification, oxide production, metal production, parts fabrication, plutonium recovery, and the recovery of americium (Am-241). The PFP has also been used for receipt and large scale storage of plutonium scrap and product materials. The PFP Final Safety Analysis Report (FSAR) was prepared by WHC to document the hazards associated with the facility, present safety analyses of potential accident scenarios, and demonstrate the adequacy of safety class structures, systems, and components (SSCs) and operational safety requirements (OSRs) necessary to eliminate, control, or mitigate the identified hazards. Documented in this Safety Evaluation Report (SER) is DOE's independent review and evaluation of the PFP FSAR and the basis for approval of the PFP FSAR. The evaluation is presented in a format that parallels the format of the PFP FSAR. As an aid to the reactor, a list of acronyms has been included at the beginning of this report. The DOE review concluded that the risks associated with conducting plutonium handling, processing, and storage operations within PFP facilities, as described in the PFP FSAR, are acceptable, since the accident safety analyses associated with these activities meet the WHC risk acceptance guidelines and DOE safety goals in SEN-35-91

  9. Optimized Evaluation System to Athletic Food Safety

    OpenAIRE

    Shanshan Li

    2015-01-01

    This study presented a new method of optimizing evaluation function in athletic food safety information programming by particle swarm optimization. The process of food information evaluation function is to automatically adjust these parameters in the evaluation function by self-optimizing method accomplished through competition, which is a food information system plays against itself with different evaluation functions. The results show that the particle swarm optimization is successfully app...

  10. NHS Blood Tracking Pilot: City University Evaluation Project

    Science.gov (United States)

    Goddard, Kate; Shabestari, Omid; Adriano, Juan; Kay, Jonathan; Roudsari, Abdul

    Automation of healthcare processes is an emergent theme in the drive to increase patient safety. The Mayday Hospital has been chosen as the pilot site for the implementation of the Electronic Clinical Transfusion Management System to track blood from the point of ordering to the final transfusion. The Centre for Health Informatics at City University is carrying out an independent evaluation of the system implementation using a variety of methodologies to both formatively inform the implementation process and summatively provide an account of the lessons learned for future implementations.

  11. SGHWR safety design and evaluation

    International Nuclear Information System (INIS)

    Smith, D.R.; Merrett, D.J.; Ward, D.A.

    1977-01-01

    The paper discusses the characteristic features of the S.G.H.W.R. and identifies the single channel concept as of considerable importance. The unique feature of the design is the provision of individual spray cooling E.C.C.S. to each channel. This spray cooling occupies a prominent position in the main line safety arguments. The reliance on this form of spray cooling leads to provision of a comprehensive E.C.C.S. system of high reliability. Duplicate systems with diverse power and water sources cover the complete pressure range to give very high confidence that spray cooling is available in all major L.O.C.A.s. On the other hand hydraulic analysis of the blowdown phase demonstrates that significant convective flow is available as an alternative/supplementary cooling regime for most faults. The reactor shutdown mechanisms have also been duplicated and will be designed to high reliabilities to give surety of reactor trip in all credible faults. The comparative performance of the two systems is considered. Extent of diversity and redundancy in trip parameters is also discussed. A feature of channel concept is that the pipe sizes can be made relatively small thus restricting rates of blowdown, and the paper discusses effects of this upon long term cooling and flooding arguments. The quantities of pipework in the primary circuit introduce considerations of integrity and the paper goes on to list the measures introduced to improve segregation and protection of individual sections of the plant so that the extent of possible L.O.C.A.s is minimised. The achievement of high standards of reliability by use of in-service inspection is covered, with particular reference to the steam drums. The impact of these inspection requirements upon the very low man-rem exposures required by U.K. utilities is also included. Finally, it is noted that the provision of containment in common with other L.W.R. practice also provides a valuable engineered safety feature. The principles of

  12. 78 FR 66006 - Meeting of the Advisory Committee on Blood and Tissue Safety and Availability

    Science.gov (United States)

    2013-11-04

    ... decision making from donor to recipient. The Committee will also hear from the World Health Organization's... include: (1) Definition of public health parameters around safety and availability of blood and blood...

  13. Safety evaluation of large ventilation networks

    International Nuclear Information System (INIS)

    Barrocas, M.; Pruchon, P.; Robin, J.P.; Rouyer, J.L.; Salmon, P.

    1981-01-01

    For large ventilation networks, it is necessary to make a safety evaluation of their responses to perturbations such as blower failure, unexpected transfers, local pressurization. This evaluation is not easy to perform because of the many interrelationships between the different parts of the networks, interrelationships coming from the circulations of workers and matetials between cells and rooms and from the usefulness of air transfers through zones of different classifications. This evaluation is all the more necessary since new imperatives in energy savings push for minimizing the air flows, which tends to render the network more sensitive to perturbations. A program to evaluate safety has been developed by the Service de Protection Technique in cooperation with operators and designers of big nuclear facilities and the first applications presented here show the weak points of the installation studied from the safety view point

  14. Squale: evaluation criteria of functioning safety

    International Nuclear Information System (INIS)

    Deswarte, Y.; Kaaniche, M.; Benoit, P.

    1998-05-01

    The SQUALE (security, safety and quality evaluation for dependable systems) project is part of the ACTS (advanced communications, technologies and services) European program. Its aim is to develop confidence evaluation criteria to test the functioning safety of systems. All industrial sectors that use critical applications (nuclear, railway, aerospace..) are concerned. SQUALE evaluation criteria differ from the classical evaluation methods: they are independent of the application domains and industrial sectors, they take into account the overall functioning safety attributes, and they can progressively change according to the level of severity required. In order to validate the approach and to refine the criteria, a first experiment is in progress with the METEOR automatic underground railway and another will be carried out on a telecommunication system developed by Bouygues company. (J.S.)

  15. Safety culture management and quantitative indicator evaluation

    International Nuclear Information System (INIS)

    Mandula, J.

    2002-01-01

    This report discuses a relationship between safety culture and evaluation of quantitative indicators. It shows how a systematic use of generally shared operational safety indicators may contribute to formation and reinforcement of safety culture characteristics in routine plant operation. The report also briefly describes the system of operational safety indicators used at the Dukovany plant. It is a PC database application enabling an effective work with the indicators and providing all users with an efficient tool for making synoptic overviews of indicator values in their links and hierarchical structure. Using color coding, the system allows quick indicator evaluation against predefined limits considering indicator value trends. The system, which has resulted from several-year development, was completely established at the plant during the years 2001 and 2002. (author)

  16. Safety evaluation of synthetic β-carotene

    NARCIS (Netherlands)

    Woutersen, R.A.; Wolterbeek, A.P.M.; Appel, M.J.; Berg, H. van den; Goldbohm, R.A.; Feron, V.J.

    1999-01-01

    The safety of β-carotene was reassessed by evaluating the relevant literature on the beneficial and adverse effects of β-carotene on cancer and, in particular, by evaluating the results of toxicity studies. β- Carotene appeared neither genotoxic nor reprotoxic or teratogenic, and no signs of organ

  17. The evaluation of blood donor deferral causes in Zimbabwe

    NARCIS (Netherlands)

    Mafirakureva, N.; Khoza, S.; Van Hulst, M.; Postma, M.J.; Mvere, D.A.

    2013-01-01

    Background: Donor selection is one of the first steps in blood donation aimed at improving the safety of blood and blood products. It is the only line of protection for donors and against certain infections for which testing is not performed. There is paucity of published data on reasons for donor

  18. Overview of clinical efficacy and safety of pharmacologic strategies for blood conservation.

    Science.gov (United States)

    Levy, Jerrold H

    2005-09-15

    The pharmacologic management of hemostasis in patients undergoing surgery with cardiopulmonary bypass is discussed. Nearly 45 studies involving 7,000 patients have reported efficacy of aprotinin in blood conservation. Both in primary coronary artery bypass graft (CABG) surgeries and in repeat surgeries, aprotinin treatment significantly reduces the incidence of blood transfusions and the number of units of blood transfused. These effects have been observed for red blood cell, platelet, and other blood products. The safety of aprotinin treatment has been extensively evaluated in randomized clinical trials, in postmarketing databases, and in systematic reviews of the literature. Overall, data do not indicate that aprotinin treatment increases mortality, myocardial infarction, or renal failure. These findings are supported by the results of a recent meta-analysis of 35 studies in patients undergoing CABG surgery. In addition, the meta-analysis suggests that aprotinin treatment was associated with a reduced incidence of stroke and a trend toward a reduced incidence of atrial fibrillation. Although lysine analogs, desmopressin, and recombinant factor VIIa are sometimes used to reduce bleeding, only aprotinin is indicated for use during CABG surgery. The future of cardiac surgery will be marked by an increasingly complex, high-risk group of patients and a greater need for multiple pharmacologic options for reducing bleeding. Pharmacologic approaches that attenuate the activation of the hemostatic system and inflammation need to be employed to decrease coagulopathies and the need for allogeneic blood administration.

  19. Processing and storage of blood components: strategies to improve patient safety

    Directory of Open Access Journals (Sweden)

    Pietersz RNI

    2015-08-01

    Full Text Available Ruby NI Pietersz, Pieter F van der Meer Department of Product and Process Development, Sanquin Blood Bank, Amsterdam, the Netherlands Abstract: This review focuses on safety improvements of blood processing of various blood components and their respective storage. A solid quality system to ensure safe and effective blood components that are traceable from a donor to the patient is the foundation of a safe blood supply. To stimulate and guide this process, National Health Authorities should develop guidelines for blood transfusion, including establishment of a quality system. Blood component therapy enabled treatment of patients with blood constituents that were missing, only thus preventing reactions to unnecessarily transfused elements. Leukoreduction prevents many adverse reactions and also improves the quality of the blood components during storage. The safety of red cells and platelets is improved by replacement of plasma with preservative solutions, which results in the reduction of isoantibodies and plasma proteins. Automation of blood collection, separation of whole blood into components, and consecutive processing steps, such as preparation of platelet concentrate from multiple donations, improves the consistent composition of blood components. Physicians can better prescribe the number of transfusions and therewith reduce donor exposure and/or the risk of pathogen transmission. Pathogen reduction in cellular blood components is the latest development in improving the safety of blood transfusions for patients. Keywords: blood components, red cell concentrates, platelet concentrates, plasma, transfusion, safety 

  20. The Interagency Nuclear Safety Review Panel's Galileo safety evaluation report

    International Nuclear Information System (INIS)

    Nelson, R.C.; Gray, L.B.; Huff, D.A.

    1989-01-01

    The safety evaluation report (SER) for Galileo was prepared by the Interagency Nuclear Safety Review Panel (INSRP) coordinators in accordance with Presidential directive/National Security Council memorandum 25. The INSRP consists of three coordinators appointed by their respective agencies, the Department of Defense, the Department of Energy (DOE), and the National Aeronautics and Space Administration (NASA). These individuals are independent of the program being evaluated and depend on independent experts drawn from the national technical community to serve on the five INSRP subpanels. The Galileo SER is based on input provided by the NASA Galileo Program Office, review and assessment of the final safety analysis report prepared by the Office of Special Applications of the DOE under a memorandum of understanding between NASA and the DOE, as well as other related data and analyses. The SER was prepared for use by the agencies and the Office of Science and Technology Policy, Executive Office of the Present for use in their launch decision-making process. Although more than 20 nuclear-powered space missions have been previously reviewed via the INSRP process, the Galileo review constituted the first review of a nuclear power source associated with launch aboard the Space Transportation System

  1. BLOOD BIOMARKERS FOR EVALUATION OF PERINATAL ENCEPHALOPATHY

    Directory of Open Access Journals (Sweden)

    Ernest Marshall Graham

    2016-07-01

    Full Text Available Recent research in identification of brain injury after trauma shows many possible blood biomarkers that may help identify the fetus and neonate with encephalopathy. Traumatic brain injury shares many common features with perinatal hypoxic-ischemic encephalopathy. Trauma has a hypoxic component, and one of the 1st physiologic consequences of moderate-severe traumatic brain injury is apnea. Trauma and hypoxia-ischemia initiate an excitotoxic cascade and free radical injury followed by the inflammatory cascade, producing injury in neurons, glial cells and white matter. Increased excitatory amino acids, lipid peroxidation products and alteration in microRNAs and inflammatory markers are common to both traumatic brain injury and perinatal encephalopathy. The blood-brain barrier is disrupted in both leading to egress of substances normally only found in the central nervous system. Brain exosomes may represent ideal biomarker containers, as RNA and protein transported within the vesicles are protected from enzymatic degradation. Evaluation of fetal or neonatal brain derived exosomes that cross the blood-brain barrier and circulate peripherally has been referred to as the liquid brain biopsy. A multiplex of serum biomarkers could improve upon the current imprecise methods of identifying fetal and neonatal brain injury such as fetal heart rate abnormalities, meconium, cord gases at delivery, and Apgar scores. Quantitative biomarker measurements of perinatal brain injury and recovery could lead to operative delivery only in the presence of significant fetal risk, triage to appropriate therapy after birth and measure the effectiveness of treatment.

  2. Problems of nuclear power plant safety evaluation

    International Nuclear Information System (INIS)

    Suchomel, J.

    1977-01-01

    Nuclear power plant safety is discussed with regard to external effects on the containment and to the human factor. As for external effects, attention is focused on shock waves which may be due to explosions or accidents in flammable material transport and storage, to missiles, and to earthquake effects. The criteria for evaluating nuclear power plant safety in different countries are shown. Factors are discussed affecting the reliability of man with regard to his behaviour in a loss-of-coolant accident in the power plant. Different types of PWR containments and their functions are analyzed, mainly in case of accident. Views are discussed on the role of destructive accidents in the overall evaluation of fast reactor safety. Experiences are summed up gained with the operation of WWER reactors with respect to the environmental impact of the nuclear power plants. (Z.M.)

  3. 76 FR 15982 - Nominations to the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2011-03-22

    ... Committee is the responsibility of the OASH. The qualified individuals will be nominated to the Secretary of... Mr. James Berger, Associate Public Health Advisor for Blood, Organ and Tissue Safety; Office of... Public Health Advisor for Blood, Organ and Tissue Safety. Contact information for Mr. Berger is provided...

  4. Operational safety evaluation for minor reactor accidents

    International Nuclear Information System (INIS)

    Wang, O.S.

    1981-01-01

    The purpose of this paper is to address a concern of applying conservatism in analysing minor reactor incidents. A so-called ''conservative'' safety analysis may exaggerate the system responses and result in a reactor scram tripped by the reactor protective system (RPS). In reality, a minor incident may lead the reactor to a new thermal hydraulic steady-state without scram, and the mitigation or termination of the incident may entirely depend on operator actions. An example on a small steamline break evaluation for a pressurized water reactor recently investigated by the staff at the Washington Public Power Supply System is presented to illustrate this point. A safety evaluation using mainly the safety-related systems to be consistent with the conservative assumptions used in the Safety Analysis Report was conducted. For comparison, a realistic analysis was also performed using both the safety- and control-related systems. The analyses were performed using the RETRAN plant simulation computer code. The ''conservative'' safety analysis predicts that the incident can be turned over by the RPS scram trips without operator intervention. However, the realistic analysis concludes that the reactor will reach a new steady-state at a different plant thermal hydraulic condition. As a result, the termination of the incident at this stage depends entirely on proper operator action. On the basis of this investigation it is concluded that, for minor incidents, ''conservative'' assumptions are not necessary, sometimes not justifiable. A realistic investigation from the operational safety point of view is more appropriate. It is essential to highlight the key transient indications for specific incident recognition in the operator training program

  5. Evaluating fuel cycle safety for CITa

    International Nuclear Information System (INIS)

    Longhurst, G.R.; Reilly, H.J.; Piet, S.J.

    1987-01-01

    A safety concern in the design of the Compact Ignition Tokamak (CIT) currently being designed in the U. S. is the accidental release of tritium. To evaluate the basis for that concern, an assessment of the risk to the public posed by CIT was conducted that made use of probabilistic risk assessment (PRA) techniques. These include both frequency and consequence elements of risk. This analysis concluded that the tritium systems on the CIT could be designed and operated as planned with negligible safety impact, well within the established guidelines. (author)

  6. 78 FR 12062 - Nominations to the Advisory Committee on Blood and Tissue Safety and Availability

    Science.gov (United States)

    2013-02-21

    ... Committee is the responsibility of the OASH. The qualified individuals will be nominated to the Secretary of... Mr. James Berger, Senior Advisor for Blood Policy; Division of Blood and Tissue Safety and...: (240) 453-8803. FOR FURTHER INFORMATION CONTACT: Mr. James Berger, Senior Advisor for Blood Policy...

  7. Safety insights from forensics evaluations at Daiichi

    Directory of Open Access Journals (Sweden)

    J. Rempe

    2017-01-01

    Information obtained from Daiichi is required to inform Decontamination and Decommissioning activities, improving the ability of the Tokyo Electric Power Company (TEPCO to characterize potential hazards and to ensure the safety of workers involved with cleanup activities. This paper reports initial results from the US Forensics Effort to utilize examination information obtained by TEPCO to enhance the safety of existing and future nuclear power plant designs. In this paper, three examples are presented in which examination information, such as visual images, dose surveys, sample evaluations, and muon tomography examinations, along with data from plant instrumentation, are used to obtain significant safety insights in the areas of component performance, fission product release and transport, debris end-state location, and combustible gas generation and transport. In addition to reducing uncertainties related to severe accident modeling progression, these insights confirm actions, such as the importance of water addition and containment venting, that are emphasized in updated guidance for severe accident prevention, mitigation, and emergency planning.

  8. The International Criticality Safety Benchmark Evaluation Project

    International Nuclear Information System (INIS)

    Briggs, B. J.; Dean, V. F.; Pesic, M. P.

    2001-01-01

    In order to properly manage the risk of a nuclear criticality accident, it is important to establish the conditions for which such an accident becomes possible for any activity involving fissile material. Only when this information is known is it possible to establish the likelihood of actually achieving such conditions. It is therefore important that criticality safety analysts have confidence in the accuracy of their calculations. Confidence in analytical results can only be gained through comparison of those results with experimental data. The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the US Department of Energy. The project was managed through the Idaho National Engineering and Environmental Laboratory (INEEL), but involved nationally known criticality safety experts from Los Alamos National Laboratory, Lawrence Livermore National Laboratory, Savannah River Technology Center, Oak Ridge National Laboratory and the Y-12 Plant, Hanford, Argonne National Laboratory, and the Rocky Flats Plant. An International Criticality Safety Data Exchange component was added to the project during 1994 and the project became what is currently known as the International Criticality Safety Benchmark Evaluation Project (ICSBEP). Representatives from the United Kingdom, France, Japan, the Russian Federation, Hungary, Kazakhstan, Korea, Slovenia, Yugoslavia, Spain, and Israel are now participating on the project In December of 1994, the ICSBEP became an official activity of the Organization for Economic Cooperation and Development - Nuclear Energy Agency's (OECD-NEA) Nuclear Science Committee. The United States currently remains the lead country, providing most of the administrative support. The purpose of the ICSBEP is to: (1) identify and evaluate a comprehensive set of critical benchmark data; (2) verify the data, to the extent possible, by reviewing original and subsequently revised documentation, and by talking with the

  9. Contribution of the Retrovirus Epidemiology Donor Study (REDS to research on blood transfusion safety in Brazil

    Directory of Open Access Journals (Sweden)

    Paula Loureiro

    2014-04-01

    Full Text Available The Retrovirus Epidemiology Donor Study (REDS program was established in the United States in 1989 with the purpose of increasing blood transfusion safety in the context of the HIV/AIDS and human T-lymphotropic virus epidemics. REDS and its successor, REDS-II were at first conducted in the US, then expanded in 2006 to include international partnerships with Brazil and China. In 2011, a third wave of REDS renamed the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III was launched. This seven-year research program focuses on both blood banking and transfusion medicine research in the United States of America, Brazil, China, and South Africa. The main goal of the international programs is to reduce and prevent the transmission of HIV/AIDS and other known and emerging infectious agents through transfusion, and to address research questions aimed at understanding global issues related to the availability of safe blood. This article describes the contribution of REDS-II to transfusion safety in Brazil. Articles published from 2010 to 2013 are summarized, including database analyses to characterize blood donors, deferral rates, and prevalence, incidence and residual risk of the main blood-borne infections. Specific studies were developed to understand donor motivation, the impact of the deferral questions, risk factors and molecular surveillance among HIV-positive donors, and the natural history of Chagas disease. The purpose of this review is to disseminate the acquired knowledge and briefly summarize the findings of the REDS-II studies conducted in Brazil as well as to introduce the scope of the REDS-III program that is now in progress and will continue through 2018.

  10. Software Dependability and Safety Evaluations ESA's Initiative

    Science.gov (United States)

    Hernek, M.

    ESA has allocated funds for an initiative to evaluate Dependability and Safety methods of Software. The objectives of this initiative are; · More extensive validation of Safety and Dependability techniques for Software · Provide valuable results to improve the quality of the Software thus promoting the application of Dependability and Safety methods and techniques. ESA space systems are being developed according to defined PA requirement specifications. These requirements may be implemented through various design concepts, e.g. redundancy, diversity etc. varying from project to project. Analysis methods (FMECA. FTA, HA, etc) are frequently used during requirements analysis and design activities to assure the correct implementation of system PA requirements. The criticality level of failures, functions and systems is determined and by doing that the critical sub-systems are identified, on which dependability and safety techniques are to be applied during development. Proper performance of the software development requires the development of a technical specification for the products at the beginning of the life cycle. Such technical specification comprises both functional and non-functional requirements. These non-functional requirements address characteristics of the product such as quality, dependability, safety and maintainability. Software in space systems is more and more used in critical functions. Also the trend towards more frequent use of COTS and reusable components pose new difficulties in terms of assuring reliable and safe systems. Because of this, its dependability and safety must be carefully analysed. ESA identified and documented techniques, methods and procedures to ensure that software dependability and safety requirements are specified and taken into account during the design and development of a software system and to verify/validate that the implemented software systems comply with these requirements [R1].

  11. Nuclear safety culture evaluation model based on SSE-CMM

    International Nuclear Information System (INIS)

    Yang Xiaohua; Liu Zhenghai; Liu Zhiming; Wan Yaping; Peng Guojian

    2012-01-01

    Safety culture, which is of great significance to establish safety objectives, characterizes level of enterprise safety production and development. Traditional safety culture evaluation models emphasis on thinking and behavior of individual and organization, and pay attention to evaluation results while ignore process. Moreover, determining evaluation indicators lacks objective evidence. A novel multidimensional safety culture evaluation model, which has scientific and completeness, is addressed by building an preliminary mapping between safety culture and SSE-CMM's (Systems Security Engineering Capability Maturity Model) process area and generic practice. The model focuses on enterprise system security engineering process evaluation and provides new ideas and scientific evidences for the study of safety culture. (authors)

  12. Evaluation of BOR-60 operation safety

    International Nuclear Information System (INIS)

    Minakov, A.A.; Antipin, G.K.; Efimov, V.N.; Kuzin, G.G.; Eschenko, L.V.; Eschenko, S.N.

    1987-12-01

    In this communication, BOR-60 reactor operation anomalies capable to produce a dangerous overheating of the core (SDC) is examined. On bases of calculations and reactor operation experience an event tree for SDC is built. Evaluations of probable anomalies entering in the event tree and reactor parameters modifications in case of anomalies are presented. In conclusion BOR-60 agree with the sovietic nuclear safety [fr

  13. Confidence in the safety of blood for transfusion: the effect of message framing.

    Science.gov (United States)

    Farrell, K; Ferguson, E; James, V; Lowe, K C

    2001-11-01

    Blood transfusion is a universally used, life-saving medical intervention. However, there are increasing concerns among patients about blood safety. This study investigates the effect of message framing, a means of presenting information, on confidence in blood transfusion safety. The same factual information regarding the safety of blood for transfusion was presented to a sample of 254 adult students (donors and nondonors) as either a gain frame (lives saved), a loss frame (lives lost), or a combined frame (a loss frame expressed in a positive context). This provided a basic two-way, between-subjects design with 1) blood donation history (donors vs. nondonors) and 2) message frame (gain, loss, and combined) functioning as the between-groups factors. It was hypothesized that participants would consider blood safer if information was presented as a gain frame. The role of stress appraisals as potential mediators of the framing effect was also explored. As predicted, participants receiving the gain-frame information were significantly more confident of the safety of blood for transfusion than those receiving loss-frame information or both. This was unaffected by donation history or appraisals of stress associated with transfusion. The extent to which blood was considered safe was negatively associated, independently of framing effects, with perceptions that transfusion was threatening. Information about transfusion should be conveyed to patients in a form focusing on the positive, rather than the negative, known facts about the safety of blood.

  14. Safety evaluation of cation-exchange resins

    International Nuclear Information System (INIS)

    Kalkwarf, D.R.

    1977-08-01

    Results are presented of a study to evaluate whether sufficient information is available to establish conservative limits for the safe use of cation-exchange resins in separating radionuclides and, if not, to recommend what new data should be acquired. The study was also an attempt to identify in-line analytical techniques for the evaluation of resin degradation during radionuclide processing. The report is based upon a review of the published literature and upon discussions with many people engaged in the use of these resins. It was concluded that the chief hazard in the use of cation-exchange resins for separating radionuclides is a thermal explosion if nitric acid or other strong oxidants are present in the process solution. Thermal explosions can be avoided by limiting process parameters so that the rates of heat and gas generation in the system do not exceed the rates for their transfer to the surroundings. Such parameters include temperature, oxidant concentration, the amounts of possible catalysts, the radiation dose absorbed by the resin and the diameter of the resin column. Current information is not sufficient to define safe upper limits for these parameters. They can be evaluated, however, from equations derived from the Frank-Kamenetskii theory of thermal explosions provided the heat capacities, thermal conductivities and rates of heat evolution in the relevant resin-oxidant mixtures are known. It is recommended that such measurements be made and the appropriate limits be evaluated. A list of additional safety precautions are also presented to aid in the application of these limits and to provide additional margins of safety. In-line evaluation of resin degradation to assess its safety hazard is considered impractical. Rather, it is recommended that the resin be removed from use before it has received the limiting radiation dose, evaluated as described above

  15. 21 CFR 315.6 - Evaluation of safety.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 5 2010-04-01 2010-04-01 false Evaluation of safety. 315.6 Section 315.6 Food and... USE DIAGNOSTIC RADIOPHARMACEUTICALS § 315.6 Evaluation of safety. (a) Factors considered in the safety...)(1) To establish the safety of a diagnostic radiopharmaceutical, FDA may require, among other...

  16. Multinational Design Evaluation Programme (MDEP) - Safety Goals

    International Nuclear Information System (INIS)

    Vaughan, G.J.

    2011-01-01

    One of the aims of the NEA's Multinational Design Evaluation Programme (MDEP) is to work towards greater harmonisation of regulatory requirements. To achieve this aim, it is necessary that there is a degree of convergence on the safety goals that are required to be met by designers and operators. The term 'safety goals' is defined to cover all health and safety requirements which must be met: these may be deterministic rules and/or probabilistic targets. They should cover the safety of workers, public and the environment in line with the IAEA's Basic Safety Objective; encompassing safety in normal operation through to severe accidents. MDEP is also interested in how its work can be extended to future reactors, which may use significantly different technology to the almost ubiquitous LWRs used today and in the next generation, building on the close co-operation within MDEP between the regulators who are currently engaged in constructing or carrying out design reviews on new designs. For two designs this work has involved several regulators sharing their safety assessments and in some cases issuing statements on issues that need to be addressed. Work is also progressing towards joint regulatory position statements on specific assessment areas. Harmonisation of safety goals will enhance the cooperation between regulators as further developments in design and technology occur. All regulators have safety goals, but these are expressed in many different ways and exercises in comparing them frequently are done at a very low level eg specific temperatures in the reactor vessel of a specific reactor type. The differences in the requirements from different regulators are difficult to resolve as the goals are derived using different principles and assumptions and are often for a specific technology. Therefore a different approach is being investigated, starting with the top-level safety goals and try to derive a structure and means of deriving lower tier

  17. A probabilistic bridge safety evaluation against floods.

    Science.gov (United States)

    Liao, Kuo-Wei; Muto, Yasunori; Chen, Wei-Lun; Wu, Bang-Ho

    2016-01-01

    To further capture the influences of uncertain factors on river bridge safety evaluation, a probabilistic approach is adopted. Because this is a systematic and nonlinear problem, MPP-based reliability analyses are not suitable. A sampling approach such as a Monte Carlo simulation (MCS) or importance sampling is often adopted. To enhance the efficiency of the sampling approach, this study utilizes Bayesian least squares support vector machines to construct a response surface followed by an MCS, providing a more precise safety index. Although there are several factors impacting the flood-resistant reliability of a bridge, previous experiences and studies show that the reliability of the bridge itself plays a key role. Thus, the goal of this study is to analyze the system reliability of a selected bridge that includes five limit states. The random variables considered here include the water surface elevation, water velocity, local scour depth, soil property and wind load. Because the first three variables are deeply affected by river hydraulics, a probabilistic HEC-RAS-based simulation is performed to capture the uncertainties in those random variables. The accuracy and variation of our solutions are confirmed by a direct MCS to ensure the applicability of the proposed approach. The results of a numerical example indicate that the proposed approach can efficiently provide an accurate bridge safety evaluation and maintain satisfactory variation.

  18. Barrier performance researches for the safety evaluation

    International Nuclear Information System (INIS)

    Niibori, Yuichi

    2004-01-01

    So far, many researches were conducted to propose a scientific evidence (a safety case) for the realization of geological disposal in Japan. In order to regulate the geological disposal system of radioactive wastes, on the other hand, we need also a holistic approach to integrate various data related for the performance evaluations of the engineered barrier system and the natural barrier system. However, the scientific bases are not sufficient to establish the safety regulation for such a natural system. For example, we often apply the specific probability density function (PDF) to the uncertainty of barrier system due to the essential heterogeneity. However, the applicability is not clear in the regulation point of view. A viewpoint to understand such an applicability of PDFs has been presented. (author)

  19. Safety of retransfusing shed blood after local infiltration analgesia in total knee arthroplasty

    NARCIS (Netherlands)

    Thomassen, B.J.; Pool, L.; Van Der Flier, R.; Stienstra, R.; in 't Veld, B.A.

    2012-01-01

    We investigated the safety of LIA (local infiltration analgesia) combined with retransfusion of drained blood. Total knee arthroplasty patients received two peri-articular injections during surgery followed by continuous infusion, both with ropivacaine (567 mg). Ropivacaine plasma concentrations

  20. Priority needs and wisdom strategy for blood transfusion safety in developing low-resource countries.

    Science.gov (United States)

    Abdelrazik, Abeer Mohamed; Ezzat Ahmed, Ghada M

    2016-02-01

    To evaluate the implementation of alternative safety measures that reduce the risk of transfusion transmissible infections as an affordable measure in low resource countries. It is still difficult in developing countries with limited resources to mandate nucleic acid testing due to its high cost. Although NAT reduces the window period of infection, the developing countries are still in need of an efficient and effective transfusion programme before implementing the complex high cost NAT. Two thousand eight hundred eighty sero-negative first-time and repeat donations from Fayoum University Hospital blood bank were individually analysed by NAT for HIV, HBV and HCV. Only discriminatory-positive NAT were classified comparing the non-remunerated and family replacement donations. Significant discriminatory-positive differences were observed for HBV NAT results, 2 remunerated donations compared to 0 non-remunerated sero-negative donations. The discriminatory positive differences were also significant for HCV NAT results, 4 remunerated donations compared to 1 non-remunerated sero-negative donation. No sero-negative, discriminatory-positive NAT HIV case was found. Seven out of 8 discriminatory positive cases were from first time donations. In order to ensure blood safety, the recruitment and retention of voluntary, non-remunerated repeat donors should be a major commitment for low resource countries in which NAT implementation is costly and not feasible. Copyright © 2016 Elsevier Ltd. All rights reserved.

  1. Managing blood pressure control in Asian patients: safety and efficacy of losartan.

    Science.gov (United States)

    Cheung, Tommy Tsang; Cheung, Bernard Man Yung

    2014-01-01

    Hypertension is common in Asian populations and is a major cause of cardiovascular diseases. The prevalence of hypertension is increasing in many Asian countries. The overall prevalence of hypertension in India and the People's Republic of China has been estimated to be 20.6% in men and 22.6% in women. However, the rates of detection, treatment, and control of hypertension remain low in Asia. This reflects a low level of literacy and education, as well as a low level of access to medical care. To overcome these obstacles, strategies targeted at education, promotion, and optimization of medical care, are crucial to achieve target blood pressure control. Angiotensin receptor blockers are one of the first-line treatments for essential hypertension because they confer better cardiovascular outcomes. Losartan has been widely evaluated for the management of hypertension. Although some studies suggested that the blood pressure-lowering effect of losartan is perhaps lower than for other angiotensin receptor blockers, losartan has been demonstrated to be beneficial in terms of renal protection in patients with diabetes, heart failure resulting from either systolic or diastolic dysfunction, and diuretic-induced hyperuricemia. However, most of these data were obtained from Caucasian populations. The efficacy and safety of losartan in Asian populations may be different because of genetic and ethnic variations. Therefore, the efficacy and safety of losartan in Asian patients with hypertension warrant further study.

  2. Safety and frequency of whole blood donations from elderly donors.

    Science.gov (United States)

    Müller-Steinhardt, M; Müller-Kuller, T; Weiss, C; Menzel, D; Wiesneth, M; Seifried, E; Klüter, H

    2012-02-01

    Within the coming decades, a steadily growing demand for blood products will face a shrinking blood donor population in many countries. After increasing the donor age of repeat donors for whole blood donation (WB) from 68 to 70 years in 2009 in our Blood Service, we investigated whether this is sufficient as a safe and effective strategy to sustain future blood supply. Between 1 March 2009 and 28 February 2011, WB donations from donors aged between 69 and 70 and their proportion of total donations in 2010 were determined. We analysed adverse reaction rates in donors with respect to sex and age and calculated mean annual donation frequencies. Of all invited donors, 32·5% responded and contributed 0·98% (men) and 0·56% (women) to all WB units collected in 2010. The overall and systemic adverse reaction rate per 1·000 WB donations declined by age [men: 1·10 (95%CI: 0·84-1·35) vs. 0 (0-0·8), P donation frequencies were strongly correlated with increasing age (men: r = 0·953, P donate blood. Thus, we consider donations from repeat donors aged 69-70 safe and suggest it a powerful short- to midterm strategy to, at least partially, overcome the challenges of the demographic change. © 2011 The Author(s). Vox Sanguinis © 2011 International Society of Blood Transfusion.

  3. A modified isometric test to evaluate blood pressure control with ...

    African Journals Online (AJOL)

    lifting and supporting weights) and have an important influence on blood pressure, it is essential to evaluate blood pressure response to iso- metric effort. This test can reveal high blood pressure that might otherwise not be detected. Only a few ...

  4. A modified isometric test to evaluate blood pressure control with ...

    African Journals Online (AJOL)

    Blood pressure at rest is not predictive of roundthe- clock values. Blood pressure should therefore be measured during effort to evaluate hypertension and its response to treatment. The effect of sustained-release verapamil (240 mg taken once a day) on blood pressure at rest and during isometric effort was therefore ...

  5. Safety evaluation for packaging (onsite) SERF cask

    International Nuclear Information System (INIS)

    Edwards, W.S.

    1997-01-01

    This safety evaluation for packaging (SEP) documents the ability of the Special Environmental Radiometallurgy Facility (SERF) Cask to meet the requirements of WHC-CM-2-14, Hazardous Material Packaging and Shipping, for transfer of Type B quantities (up to highway route controlled quantities) of radioactive material within the 300 Area of the Hanford Site. This document shall be used to ensure that loading, tie down, transport, and unloading of the SERF Cask are performed in accordance with WHC-CM-2-14. This SEP is valid until October 1, 1999. After this date, an update or upgrade to this document is required

  6. Safety evaluation for packaging CPC metal boxes

    International Nuclear Information System (INIS)

    Romano, T.

    1995-01-01

    This Safety Evaluation for Packaging (SEP) provides authorization for the use of Container Products Corporation (CPC) metal boxes, as described in this document, for the interarea shipment of radioactive contaminated equipment and debris for storage in the Central Waste Complex (CWC) or T Plant located in the 200 West Area. Authorization is granted until November 30, 1995. The CPC boxes included in this SEP were originally procured as US Department of Transportation (DOT) Specification 7A Type A boxes. A review of the documentation provided by the manufacturer revealed the documentation did not adequately demonstrate compliance to the 4 ft drop test requirement of 49 CFR 173.465(c). Preparation of a SEP is necessary to document the equivalent safety of the onsite shipment in lieu of meeting DOT packaging requirements until adequate documentation is received. The equivalent safety of the shipment is based on the fact that the radioactive contents consist of contaminated equipment and debris which are not dispersible. Each piece is wrapped in two layers of no less than 4 mil plastic prior to being placed in the box which has an additional 10 mil liner. Pointed objects and sharp edges are padded to prevent puncture of the plastic liner and wrapping

  7. Delta check for blood groups: A step ahead in blood safety

    Directory of Open Access Journals (Sweden)

    Raj Nath Makroo

    2017-01-01

    Conclusion: Delta checks proved to be an effective tool for detecting blood group errors and prevention of accidental mismatched blood transfusions. Preanalytical errors in patient identification or sample labeling were the most frequent.

  8. Safety and radiation risks in the labelling of blood cells

    International Nuclear Information System (INIS)

    Gonzalez, B.M.

    1994-01-01

    Risk in the management of radioactive material and biological exposition to infectious agents. Protocols and normative to observe GOOD RADIOPHARMACY Practices. Main infectious agents that may be transmitted during preparation of a blood cell radiopharmaceutical. Problems of contamination

  9. Preliminary safety evaluation for CSR1000 with passive safety system

    International Nuclear Information System (INIS)

    Wu, Pan; Gou, Junli; Shan, Jianqiang; Zhang, Bo; Li, Xiang

    2014-01-01

    Highlights: • The basic information of a Chinese SCWR concept CSR1000 is introduced. • An innovative passive safety system is proposed for CSR1000. • 6 Transients and 3 accidents are analysed with system code SCTRAN. • The passive safety systems greatly mitigate the consequences of these incidents. • The inherent safety of CSR1000 is enhanced. - Abstract: This paper describes the preliminary safety analysis of the Chinese Supercritical water cooled Reactor (CSR1000), which is proposed by Nuclear Power Institute of China (NPIC). The two-pass core design applied to CSR1000 decreases the fuel cladding temperature and flattens the power distribution of the core at normal operation condition. Each fuel assembly is made up of four sub-assemblies with downward-flow water rods, which is favorable to the core cooling during abnormal conditions due to the large water inventory of the water rods. Additionally, a passive safety system is proposed for CSR1000 to increase the safety reliability at abnormal conditions. In this paper, accidents of “pump seizure”, “loss of coolant flow accidents (LOFA)”, “core depressurization”, as well as some typical transients are analysed with code SCTRAN, which is a one-dimensional safety analysis code for SCWRs. The results indicate that the maximum cladding surface temperatures (MCST), which is the most important safety criterion, of the both passes in the mentioned incidents are all below the safety criterion by a large margin. The sensitivity analyses of the delay time of RCPs trip in “loss of offsite power” and the delay time of RMT actuation in “loss of coolant flowrate” were also included in this paper. The analyses have shown that the core design of CSR1000 is feasible and the proposed passive safety system is capable of mitigating the consequences of the selected abnormalities

  10. Addressing safety liabilities of TfR bispecific antibodies that cross the blood-brain barrier.

    Science.gov (United States)

    Couch, Jessica A; Yu, Y Joy; Zhang, Yin; Tarrant, Jacqueline M; Fuji, Reina N; Meilandt, William J; Solanoy, Hilda; Tong, Raymond K; Hoyte, Kwame; Luk, Wilman; Lu, Yanmei; Gadkar, Kapil; Prabhu, Saileta; Ordonia, Benjamin A; Nguyen, Quyen; Lin, Yuwen; Lin, Zhonghua; Balazs, Mercedesz; Scearce-Levie, Kimberly; Ernst, James A; Dennis, Mark S; Watts, Ryan J

    2013-05-01

    Bispecific antibodies using the transferrin receptor (TfR) have shown promise for boosting antibody uptake in brain. Nevertheless, there are limited data on the therapeutic properties including safety liabilities that will enable successful development of TfR-based therapeutics. We evaluate TfR/BACE1 bispecific antibody variants in mouse and show that reducing TfR binding affinity improves not only brain uptake but also peripheral exposure and the safety profile of these antibodies. We identify and seek to address liabilities of targeting TfR with antibodies, namely, acute clinical signs and decreased circulating reticulocytes observed after dosing. By eliminating Fc effector function, we ameliorated the acute clinical signs and partially rescued a reduction in reticulocytes. Furthermore, we show that complement mediates a residual decrease in reticulocytes observed after Fc effector function is eliminated. These data raise important safety concerns and potential mitigation strategies for the development of TfR-based therapies that are designed to cross the blood-brain barrier.

  11. Improving health profile of blood donors as a consequence of transfusion safety efforts

    DEFF Research Database (Denmark)

    Edgren, Gustaf; Tran, Trung Nam; Hjalgrim, Henrik

    2007-01-01

    BACKGROUND: Transfusion safety rests heavily on the health of blood donors. Although they are perceived as being healthier than average, little is known about their long-term disease patterns and to which extent the blood banks' continuous efforts to optimize donor selection has resulted...... in improvements. Mortality and cancer incidence among blood donors in Sweden and Denmark was investigated. STUDY DESIGN AND METHODS: All computerized blood bank databases were compiled into one database, which was linked to national population and health data registers. With a retrospective cohort study design, 1......,110,329 blood donors were followed for up to 35 years from first computer-registered blood donation to death, emigration, or December 31, 2002. Standardized mortality and incidence ratios expressed relative risk of death and cancer comparing blood donors to the general population. RESULTS: Blood donors had...

  12. Safety evaluation of the Dalat research reactor operation

    International Nuclear Information System (INIS)

    Long, V.H.; Lam, P.V.; An, T.K.

    1989-01-01

    After an introduction presenting the essential characteristics of the Dalat Nuclear Research Reactor, the document presents i) The safety assurance condition of the reactor, ii) Its safety behaviour after 5 years of operation, iii) Safety research being realized on the reactor. Following is questionnaire of safety evaluation and a list of attachments, which concern the reactor

  13. [Safety evaluation of niuhuang jiedu tablet].

    Science.gov (United States)

    Feng, Yu-Ling; Miao, Jia-wei; Li, Jing; Sung, An-Sheng; Liu, Jie

    2014-09-01

    Realgar-containing Niuhuang Jiedu tablet (NHJD) has been applied in clinic for more than 800 years. However, because realgar contains arsenic (As), it has aroused wide concerns and controversies both at home and abroad. Currently, there are two misunderstandings about realgar-containing Chinese patent medicines. First, some people exaggerated realgar's toxicity as that of arsenic. Second, they recommended to remove realgar from traditional Chinese medicine compounds. In this paper, the authors summarized the advance in studies on NHJD, and proposed different opinions: (1) It is inappropriate to take total As as the index in safety evaluation of NHJD. (2) The toxicity of NHJD is dependent on the dose and duration of administration. (3) Realgar is an active ingredient of NHJD, and shall be deeply studied. Classic realgar-containing traditional Chinese medicine prescriptions, such as Niuhuang Jiedu tablet, shall be evaluated with rigorous modern scientific basis, with the aim to guide rational and safe application.

  14. Evaluation of blood zinc, calcium and blood lead levels among children aged 1-36 months.

    Science.gov (United States)

    Ji, Xiaojun; He, Hong; Ren, Lisheng; Liu, Ji; Han, Chunhua

    2014-09-01

    Early childhood lead exposure is associated with numerous adverse health effects. Biomonitoring among susceptible populations, such as children, has not been previously conducted. The aim of the study is to evaluate the blood lead (Pb) and total blood calcium (Ca) levels; blood zinc (Zn) levels. A cross-sectional study was designed to collect healthy children age 1- 36 months (Mean ± SD: 1.5 ± 0.6 age, 60% boys) in the study from January 2010 to September 2011. The overall mean blood Pb levels were 42.18 ± 12.13 μg/L, the overall mean blood Zn and total blood Ca concentrations were 62.18 ± 12.33 μmol/L and 1.78 ± 0.13 mmol/L, respectively. The prevalence of elevated blood Pb levels in all children was 1.3%. A significant difference was found between female and male subjects for the blood Pb and Zn. After controlling for gender and age, there was a weak positive correlation between total blood Ca and Zn level. The blood Pb levels had a significant negative correlation with total blood Ca level after adjusting for age and gender, and these findings suggest that Pb had effect on positive blood Zn and total blood Ca levels; parents should pay more attention to the nutrition of girls. Copyright AULA MEDICA EDICIONES 2014. Published by AULA MEDICA. All rights reserved.

  15. Safety evaluation of Tokai reprocessing plant (TRP). Report of safety evaluation of Tokai reprocessing plant

    International Nuclear Information System (INIS)

    Yamauchi, Takamichi; Maki, Akira; Nojiri, Ichiro

    1999-02-01

    The fire and explosion incident of the bituminization facility happened in March 1997 although JNC had taken enough care of the safety of TRP. JNC reflected on it and decided to evaluate the safety of TRP voluntarily. This evaluation has included five activities, that is, (1) confirmation of the structure and organization of TRP, (2) research of the data for operation, radiation and maintenance of TRP, (3) research of reflection of the accidents and troubles which have happened at the past, (4) evaluation on the prevention system, (5) evaluation on the mitigation system. We publish this report to contribute to inheritance of accumulated knowledge and techniques from generation to generation, and remind us of lesson from the fire and explosion incident of the bituminization. (author)

  16. Perceived blood transfusion safety: A cross-European comparison

    NARCIS (Netherlands)

    Merz, E.M.; Zijlstra, B.J.H.; de Kort, W.L.A.M.

    2016-01-01

    Background and Objectives During the past decades, blood transfusions have become an ever safer clinical procedure in developed countries. Extensive donor screening together with improved infectious disease testing has led to a minimization of risks for transfusion recipients. Still, the general

  17. Perceived blood transfusion safety: a cross-European comparison

    NARCIS (Netherlands)

    Merz, E.-M.; Zijlstra, B. J. H.; de Kort, W. L. A. M.

    2016-01-01

    During the past decades, blood transfusions have become an ever safer clinical procedure in developed countries. Extensive donor screening together with improved infectious disease testing has led to a minimization of risks for transfusion recipients. Still, the general public perceives the process

  18. Perceived blood transfusion safety. A cross-European comparison

    NARCIS (Netherlands)

    Merz, E.M.; Zijlstra, B.J.H.; De Kort, W.L.A.M.

    2016-01-01

    Background and Objectives: During the past decades, blood transfusions have become an ever safer clinical procedure in developed countries. Extensive donor screening together with improved infectious disease testing has led to a minimization of risks for transfusion recipients. Still, the general

  19. A Methodology for Evaluating Quantitative Nuclear Safety Culture Impact

    International Nuclear Information System (INIS)

    Han, Kiyoon; Jae, Moosung

    2015-01-01

    Through several accidents of NPPs including the Fukushima Daiichi in 2011 and Chernobyl accidents in 1986, nuclear safety culture has been emphasized in reactor safety world-widely. In Korea, KHNP evaluates the safety culture of NPP itself. KHNP developed the principles of the safety culture in consideration of the international standards. A questionnaire and interview questions are also developed based on these principles and it is used for evaluating the safety culture. However, existing methodology to evaluate the safety culture has some disadvantages. First, it is difficult to maintain the consistency of the assessment. Second, the period of safety culture assessment is too long (every two years) so it has limitations in preventing accidents occurred by a lack of safety culture. Third, it is not possible to measure the change in the risk of NPPs by weak safety culture since it is not clearly explains the effect of safety culture on the safety of NPPs. In this study, Safety Culture Impact Assessment Model (SCIAM) is developed overcoming these disadvantages. In this study, SCIAM which overcoming disadvantages of exiting safety culture assessment method is developed. SCIAM uses SCII to monitor the statues of the safety culture periodically and also uses RCDF to quantify the safety culture impact on NPP's safety. It is significant that SCIAM represents the standard of the healthy nuclear safety culture, while the exiting safety culture assessment presented only vulnerability of the safety culture of organization. SCIAM might contribute to monitoring the level of safety culture periodically and, to improving the safety of NPP

  20. A Methodology for Evaluating Quantitative Nuclear Safety Culture Impact

    Energy Technology Data Exchange (ETDEWEB)

    Han, Kiyoon; Jae, Moosung [Hanyang University, Seoul (Korea, Republic of)

    2015-05-15

    Through several accidents of NPPs including the Fukushima Daiichi in 2011 and Chernobyl accidents in 1986, nuclear safety culture has been emphasized in reactor safety world-widely. In Korea, KHNP evaluates the safety culture of NPP itself. KHNP developed the principles of the safety culture in consideration of the international standards. A questionnaire and interview questions are also developed based on these principles and it is used for evaluating the safety culture. However, existing methodology to evaluate the safety culture has some disadvantages. First, it is difficult to maintain the consistency of the assessment. Second, the period of safety culture assessment is too long (every two years) so it has limitations in preventing accidents occurred by a lack of safety culture. Third, it is not possible to measure the change in the risk of NPPs by weak safety culture since it is not clearly explains the effect of safety culture on the safety of NPPs. In this study, Safety Culture Impact Assessment Model (SCIAM) is developed overcoming these disadvantages. In this study, SCIAM which overcoming disadvantages of exiting safety culture assessment method is developed. SCIAM uses SCII to monitor the statues of the safety culture periodically and also uses RCDF to quantify the safety culture impact on NPP's safety. It is significant that SCIAM represents the standard of the healthy nuclear safety culture, while the exiting safety culture assessment presented only vulnerability of the safety culture of organization. SCIAM might contribute to monitoring the level of safety culture periodically and, to improving the safety of NPP.

  1. [Economic analysis versus the principle of guaranteed safety in blood transfusion].

    Science.gov (United States)

    Moatti, J P; Loubière, S; Rotily, M

    2000-06-01

    This article shows that policies aimed at reducing risks of infectious agents transmissible through blood unfortunately follow a law of 'diminishing returns': increasing marginal costs have to be devoted for limited reductions in the risks of contamination through blood donations. Therefore, the economic cost-effectiveness analysis is appropriate to identify screening strategies which may minimize costs to reach a certain level of safety. Moreover, economic analysis can contribute to public debates about the level of residual risk that society is willing to accept. Empirical results from French studies about screening for hepatitis C virus (HCV) in individuals who have received blood transfusions and in blood donations are presented to illustrate these points.

  2. Safety Evaluation of Roundabouts in Georgia

    Science.gov (United States)

    2018-02-28

    Several previous studies have documented significant safety benefits of roundabouts in the United Sates. However, the safety benefits for a given roundabout may vary depending on factors such as the familiarity of the driving population to roundabout...

  3. Safety design and evaluation policy for future FBRs in Japan

    International Nuclear Information System (INIS)

    Aizawa, Kiyoto

    1991-01-01

    The safety policy for fast breeder reactors (FBRs) has gradually matured in accordance with the development of FBRs. The safety assessment of the Japanese prototype FBR, Monju during the licensing process accelerated the maturity and the integration of knowledge and databases. Results are expected to be reflected in the establishment of the safety design and evaluation policy for FBRs. Although the methodologies and safety policies developed for LWRs are applicable in principle to future FBRs, it is neither rational nor realistic to treat safety only with these policies. It is recommended that one should develop the methodologies and safety policies starting from understanding of the inherent safety characteristics of FBR's through safety research, plant operating experience and design work. In the last few years, some technical committees were organized in Japan and have discussed key safety issues which are specific to FBRs in order to provide preparatory reports and to establish safety standards and guidelines for future commercial FBRs. (author)

  4. A comprehensive protocol to evaluate the use of blood and its components in Latin America and the Caribbean

    Directory of Open Access Journals (Sweden)

    Ana E. del Pozo

    2015-06-01

    Full Text Available Blood transfusion safety is a critical part of appropriate health care. Considering the limited information available on the use of blood and its components in Latin America and the Caribbean, the Grupo Cooperativo iberoamericano de Medicina Transfusional (Ibero-American Cooperative Group for Transfusion Medicine; GCIAMT, through its Research and International Affairs committees, carried out a project to develop a protocol that would facilitate the evaluation of blood usage at the country, jurisdiction, and institutional levels in varied country contexts. Experts in blood safety from the Pan American Health Organization (Washington, DC, United States, the University of São Paulo (São Paulo, Brazil, the Hemocentro of São Paulo (São Paulo, Brazil, and GCIAMT designed a 2-step comprehensive blood-use evaluation protocol: step 1 collects data from blood requests, and step 2, from medical charts. At a minimum, 1 000 analyzed requests are necessary; as such, study periods vary depending on the number of transfusion requests issued. An Internet-based application, the Modular Research System-Study Management System (MRS-SMS, houses the data and produces reports on how hospitals request blood, how blood is issued, who requires blood and blood components, and as an added benefit, how many blood units are wasted and what the real demand for blood is.

  5. Safety profile and long-term engraftment of human CD31+ blood progenitors in bone tissue engineering.

    Science.gov (United States)

    Zigdon-Giladi, Hadar; Elimelech, Rina; Michaeli-Geller, Gal; Rudich, Utai; Machtei, Eli E

    2017-07-01

    Endothelial progenitor cells (EPCs) participate in angiogenesis and induce favorable micro-environments for tissue regeneration. The efficacy of EPCs in regenerative medicine is extensively studied; however, their safety profile remains unknown. Therefore, our aims were to evaluate the safety profile of human peripheral blood-derived EPCs (hEPCs) and to assess the long-term efficacy of hEPCs in bone tissue engineering. hEPCs were isolated from peripheral blood, cultured and characterized. β tricalcium phosphate scaffold (βTCP, control) or 10 6 hEPCs loaded onto βTCP were transplanted in a nude rat calvaria model. New bone formation and blood vessel density were analyzed using histomorphometry and micro-computed tomography (CT). Safety of hEPCs using karyotype analysis, tumorigenecity and biodistribution to target organs was evaluated. On the cellular level, hEPCs retained their karyotype during cell expansion (seven passages). Five months following local hEPC transplantation, on the tissue and organ level, no inflammatory reaction or dysplastic change was evident at the transplanted site or in distant organs. Direct engraftment was evident as CD31 human antigens were detected lining vessel walls in the transplanted site. In distant organs human antigens were absent, negating biodistribution. Bone area fraction and bone height were doubled by hEPC transplantation without affecting mineral density and bone architecture. Additionally, local transplantation of hEPCs increased blood vessel density by nine-fold. Local transplantation of hEPCs showed a positive safety profile. Furthermore, enhanced angiogenesis and osteogenesis without mineral density change was found. These results bring us one step closer to first-in-human trials using hEPCs for bone regeneration. Copyright © 2017 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.

  6. Method of safety evaluation in nuclear power plants

    International Nuclear Information System (INIS)

    Kuraszkiewicz, P.; Zahn, P.

    1988-01-01

    A novel quantitative technique for evaluating safety of subsystems of nuclear power plants based on expert estimations is presented. It includes methods of mathematical psychology recognizing the effect of subjective factors in the expert estimates and, consequently, contributes to further objectification of evaluation. It may be applied to complementing probabilistic safety assessment. As a result of such evaluations a characteristic 'safety of nuclear power plants' is obtained. (author)

  7. Dengue viremia in blood donors in Northern India: Challenges of emerging dengue outbreaks to blood transfusion safety

    Directory of Open Access Journals (Sweden)

    Sadhana Mangwana

    2015-01-01

    Full Text Available Backdround: Emerging infectious diseases pose threats to the general human population; including recipients of blood transfusions. Dengue is spreading rapidly to new areas and with increasing frequency of major outbreaks. Screening blood for dengue antigens in dengue-endemic countries would be costly and should, therefore, be recommended only after careful assessment of risk for infection and cost. Aim: A prospective study was conducted to establish the magnitude of the threat that dengue poses to blood safety where it is sporadic with seasonal variations, to quantify risk and to assess that whether screening is feasible and cost-effective. Materials and Methods: Nonstructural protein 1 (NS1 antigen test was done on 1709 donations during dengue outbreak in the months August to November 2013 as an additional test using Bio-Rad Platelia Dengue NS1AG test kit which is one step sandwich format microplate enzyme immunoassay using murine monoclonal antibodies for capture and revelation. Chi-square test was used to find statistical significance. Results and Conclusions: Majority cases were whole blood, replacement, male donors with 76.10% donors in <35 years age group. About 17.85% were single donor platelet donations. NS1 antigen in all donors was negative. In the past, dengue affected mainly children who do not donate blood. With the changing trend, mean age of infection increased affecting the population that does donate blood, further reducing blood donation pool. Further studies need to be done in different geographic regions of the country during dengue transmission season to establish maximum incidence of viremic donations, rates of transfusion transmission and clinical consequences in recipients. If risk is found to be substantial, decision will be taken by the policymakers at what threshold screening should be instituted to ensure safe blood transfusion.

  8. Expensive blood safety initiatives may offer less benefit than we think

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Hjalgrim, Henrik; Edgren, Gustaf

    2010-01-01

    Various blood safety initiatives have ensured a historically low risk of infection transmission through blood transfusion. Although further prevention of infection transmission is possible through, for example, nucleic acid testing and future introduction of pathogen inactivation, such initiative...... are very costly in relation to the benefit they offer. Although estimation of the cost-effectiveness requires detailed information about the survival of transfusion recipients, previous cost-effectiveness analyses have relied on incorrect survival assumptions....

  9. Evaluation of MSCTA for parasitic blood supply in hepatic carcinoma

    International Nuclear Information System (INIS)

    Yang Weihong; Liu Pengcheng; Liang Shanhu; Yuan Zhidong; Yu Hongjian; Deng Qianhua

    2008-01-01

    Objective: To evaluate the multi-slice spiral computer tomography for hepatocarcinoma parasitic blood supply, and analyze the mechanism of the parasitic angiogenesis. Methods: Forty cases confirmed by DSA and confirmed with the existence of parasitic blood supply through manifestations of MSCTA were retrospectively analized. Comparing the coincidence of different reconstruction modalities of MSCTA and DSA in displaying the parasitic blood supply and then to assess the characteristics of MSCTA of the cases with existing parasitic blood supply. Results: DSA displayed parasitic blood supply in 50 arterial rami and MSCTA displayed only 40 rami, with positive rate of 80%. The best display could be reached by the reconstruction of combining MIP and VRT. This kind of reconstruction revealed not only the parasitic blood supply but also the peripheral sites of the primary focci with average length of diameter of 6.9 cm. Conclusions: MSCTA possesses nearly the same capability with DSA in demonstrating the parasitic blood supply to primary hepatic carcinoma, therefore it could be utilized in evaluation of intervention therapy and surgical, operation and transplantation. The primary hepatic carcinoma with this kind of parasitic blood supply is always located at the bare were of liver and ligmentarn suspensoram together with direct invasion of nearby organs with adhesions may contribute the main factor of parasitic blood supply, furthermore the repetition of TACE inducing the decrease of collateral circulation may also be the another major factor. (authors)

  10. Evaluation of MSCTA for parasitic blood supply in hepatic carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Weihong, Yang; Pengcheng, Liu; Shanhu, Liang; Zhidong, Yuan; Hongjian, Yu; Qianhua, Deng [Department of Radiology, Shenzhen Hospital of Beijing College, Guangdong, Shenzhen (China)

    2008-09-15

    Objective: To evaluate the multi-slice spiral computer tomography for hepatocarcinoma parasitic blood supply, and analyze the mechanism of the parasitic angiogenesis. Methods: Forty cases confirmed by DSA and confirmed with the existence of parasitic blood supply through manifestations of MSCTA were retrospectively analized. Comparing the coincidence of different reconstruction modalities of MSCTA and DSA in displaying the parasitic blood supply and then to assess the characteristics of MSCTA of the cases with existing parasitic blood supply. Results: DSA displayed parasitic blood supply in 50 arterial rami and MSCTA displayed only 40 rami, with positive rate of 80%. The best display could be reached by the reconstruction of combining MIP and VRT. This kind of reconstruction revealed not only the parasitic blood supply but also the peripheral sites of the primary focci with average length of diameter of 6.9 cm. Conclusions: MSCTA possesses nearly the same capability with DSA in demonstrating the parasitic blood supply to primary hepatic carcinoma, therefore it could be utilized in evaluation of intervention therapy and surgical, operation and transplantation. The primary hepatic carcinoma with this kind of parasitic blood supply is always located at the bare were of liver and ligmentarn suspensoram together with direct invasion of nearby organs with adhesions may contribute the main factor of parasitic blood supply, furthermore the repetition of TACE inducing the decrease of collateral circulation may also be the another major factor. (authors)

  11. Nuclear safety. How is it evaluated?

    International Nuclear Information System (INIS)

    Andersson, Kjell; Andersson, Johan; Carlsson, Lennart; Olsson, Richard; Ericsson, A.M.; Gunsell, L.; Wene, C.O.

    1996-09-01

    A working group with representatives for the three subject areas reactor safety, disposal of spent fuels and transport of radioactive materials has performed a project aiming to clarify similarities and differences of the three areas concerning methods for safety analysis, criteria, risks etc; and to develop contacts between experts in the areas in order to facilitate transfer of methods. Some of the more precise objectives were: To identify common problems that could be solved jointly, to discuss prospects for a 'meta-method' that can support safety analysis in the entire field of nuclear safety, and to discuss possibilities for a homogeneous attitude towards risk management

  12. Evaluation of operating experience with safety values

    International Nuclear Information System (INIS)

    Bung, W.; Hoemke, P.; Oberender, W.; Paul, H.; Rueter, W.

    1985-01-01

    This report describes statistical investigations of 2076 functional tests carried out on power operated safety valves in conventional power plants in 1972 until 1983 with special regard to Common Mode-Failures. The results clearly show that Common Mode-Failures play an important part of non-availability for the controlled safety valves, especially in the control system. The 'Deutsche Risikostudie' does not consider any Common Mode-Failures of the primary safety valves. However there is no significant increase of the risk resulted by the primary safety valves in the 'Referenzanlage' if the calculated Common Mode-Failures probabilities are considered. (orig.) [de

  13. The approaches of safety design and safety evaluation at HTTR (High Temperature Engineering Test Reactor)

    International Nuclear Information System (INIS)

    Iigaki, Kazuhiko; Saikusa, Akio; Sawahata, Hiroaki; Shinozaki, Masayuki; Tochio, Daisuke; Honma, Fumitaka; Tachibana, Yukio; Iyoku, Tatsuo; Kawasaki, Kozo; Baba, Osamu

    2006-06-01

    Gas Cooled Reactor has long history of nuclear development, and High Temperature Gas Cooled Reactor (HTGR) has been expected that it can be supply high temperature energy to chemical industry and to power generation from the points of view of the safety, the efficiency, the environment and the economy. The HTGR design is tried to installed passive safety equipment. The current licensing review guideline was made for a Low Water Reactor (LWR) on safety evaluation therefore if it would be directly utilized in the HTGR it needs the special consideration for the HTGR. This paper describes that investigation result of the safety design and the safety evaluation traditions for the HTGR, comparison the safety design and safety evaluation feature for the HTGT with it's the LWR, and reflection for next HTGR based on HTTR operational experiment. (author)

  14. Equilibrium blood pool scanning in the evaluation of hemophilic arthropathy

    International Nuclear Information System (INIS)

    Spies, S.; Green, D.; Rana, N.A.; Milgram, J.W.; Mintzer, R.

    1978-01-01

    Arthropathy was evaluated in six patients with severe hemophilia (factor VIII<1%) using the technique of blood pool scanning. Employing an in vivo method for erythrocyte labelling with technetium-99m, a dynamic perfusion sequence was obtained using a scintillation camera over the joint(s) to be examined. Subsequently, equilibrium blood pool images of the joints were obtained to determine regional blood volume. In young patients with repeated episodes of acute hemarthrosis, increased vascularity and increased blood pool in the affected joints were demonstrated. In older patients with fixed, contracted joints and degenerative arthropathy, vascularity and regional blood volume were not abnormal. Blood pool scanning is a safe, non-invasive technique that augments the clinical and radiographic examination of the joints. The method is helpful in distinguishing acute joint bleeding from chronic synovitis and arthritis, and may prove useful in selecting patients for synovectomy. (author)

  15. Radionuclide sorption from the safety evaluation perspective

    International Nuclear Information System (INIS)

    1992-01-01

    Research and development directed towards the assessment of the long-term performance of radioactive waste disposal systems has been recognised as a priority area with a strong need for international co-operation and co-ordination. The ultimate aims is to promote the quality and credibility of safety assessment techniques for radioactive waste disposal. Sorption in the geosphere is one of the key processes for retarding the transport of radionuclide from the underground disposal facility to the biosphere. In many cases, sorption in the near field and in the biosphere is also important. A workshop, organised to favor discussion around a small number of invited papers, was held in October 1991: - to evaluate critically the way sorption processes are incorporated in performance assessment models; - to identify open issues of high priority, and; - to propose future activities to resolve these issues. These proceedings reproduce the invited papers and the conclusions and recommendations adopted by the workshop. Eight papers are in the INIS SCOPE. The main subjects studied are: sorption database comparison, sorption database development and three case studies, experimental techniques, adsorption models

  16. Development of inspection safety evaluation technology

    Energy Technology Data Exchange (ETDEWEB)

    Yoon, Seok Chul; Yoon, Yeo Chang; Kim, Jong Soo; Lee, Tae Young; Kim, Chang Ryol; Lee, Hyung Sub; Kim, Jong Soo

    1995-12-01

    The purpose of this project is to protection nation inspector`s over exposure from radiation that can be occurred by inspection activity at nuclear facilities and its environment, and to ensure the safety of inspection activity at the nuclear facilities. To effectively carry out the domestic inspection task to be enforced from 1996, the evaluation for special radiation exposure rate of nuclear facilities, air and surface contamination level, and measurement and monitoring of water contamination level were made to determine whether these measured values exceeded permissible limitations, and to protect the inspector`s over exposure from radiation at domestic nuclear facilities. Management of inspector`s exposure was carried out under assistance of the Department of Health Physics. Performance tests of two gamma detectors, one neutron detector, alpha and beta detector, and gamma spectroscopy analyzer were carried out to control dose on extremity, the characteristic test for extremity dosimeter was carried out and the theoretical calculation of gamma dose conversion factors based on ANSI N13.32 standard was performed. Under the 93+2 program, IAEA began to recognize the necessity of environmental observation technology development of air-borne particulates travelled from long distance location. Associated with the necessity of this technology development, a proposal of international joint research for development of the special radiation measurement and analysis has been prepared. (author). 21 tabs., 24 figs., 20 refs.

  17. Evaluation of Safety Culture Implementation and Socialization Results

    International Nuclear Information System (INIS)

    Situmorang, Johnny

    2003-01-01

    Evaluation of safety culture implementation and socialization results has been perform. Evaluation is carried out with specifying safety culture indicators, namely: Meeting between management and employee, system for incidents analysis, training activities related to improving safety, meeting with regulator, contractors, surveys on behavioural attitudes, and resources allocated to promote safety culture. Evaluation is based on observation and visiting the facilities to show the compliance indicator in term of good practices in the frame of safety culture implementation. For three facilities of research reactors, Kartini Yogyakarta, TRIGA Mark II Bandung and MPR-GAS Serpong, implementation of safety culture is considered good enough and progressive. Furthermore some indicator should be considered more intensive, for example the allocated resources, self assesment based on own questionnaire in the frame of improving the safety culture implementation. (author)

  18. Safety Evaluation Approach with Security Controls for Safety I and C Systems on Nuclear Power Plants

    International Nuclear Information System (INIS)

    Kim, D. H.; Jeong, S. Y.; Kim, Y. M.; Park, H. S.; Lee, M. S.; Kim, T. H.

    2016-01-01

    This paper addresses concepts of safety and security and relations between them for assessing effects of security features in safety systems. Also, evaluation approach for avoiding confliction with safety requirements and cyber security features which may be adopted in safety-related digital I and C system will be described. In this paper, safety-security life cycle model based confliction avoidance method was proposed to evaluate the effects when the cyber security control features are implemented in the safety I and C system. Also, safety effect evaluation results using the proposed evaluation method were described. In case of technical security controls, many of them are expected to conflict with safety requirements, otherwise operational and managerial controls are not relatively. Safety measures and cyber security measures for nuclear power plants should be implemented not to conflict with one another. Where safety function and security features are both required within the systems, and also where security features are implemented within safety systems, they should be justified

  19. Safety Evaluation Approach with Security Controls for Safety I and C Systems on Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Kim, D. H.; Jeong, S. Y.; Kim, Y. M.; Park, H. S. [KINS, Daejeon (Korea, Republic of); Lee, M. S.; Kim, T. H. [Formal Works Inc., Seoul (Korea, Republic of)

    2016-05-15

    This paper addresses concepts of safety and security and relations between them for assessing effects of security features in safety systems. Also, evaluation approach for avoiding confliction with safety requirements and cyber security features which may be adopted in safety-related digital I and C system will be described. In this paper, safety-security life cycle model based confliction avoidance method was proposed to evaluate the effects when the cyber security control features are implemented in the safety I and C system. Also, safety effect evaluation results using the proposed evaluation method were described. In case of technical security controls, many of them are expected to conflict with safety requirements, otherwise operational and managerial controls are not relatively. Safety measures and cyber security measures for nuclear power plants should be implemented not to conflict with one another. Where safety function and security features are both required within the systems, and also where security features are implemented within safety systems, they should be justified.

  20. Survey and evaluation of inherent safety characteristics and passive safety systems for use in probabilistic safety analyses

    International Nuclear Information System (INIS)

    Wetzel, N.; Scharfe, A.

    1998-01-01

    The present report examines the possibilities and limits of a probabilistic safety analysis to evaluate passive safety systems and inherent safety characteristics. The inherent safety characteristics are based on physical principles, that together with the safety system lead to no damage. A probabilistic evaluation of the inherent safety characteristic is not made. An inventory of passive safety systems of accomplished nuclear power plant types in the Federal Republic of Germany was drawn up. The evaluation of the passive safety system in the analysis of the accomplished nuclear power plant types was examined. The analysis showed that the passive manner of working was always assumed to be successful. A probabilistic evaluation was not performed. The unavailability of the passive safety system was determined by the failure of active components which are necessary in order to activate the passive safety system. To evaluate the passive safety features in new concepts of nuclear power plants the AP600 from Westinghouse, the SBWR from General Electric and the SWR 600 from Siemens, were selected. Under these three reactor concepts, the SWR 600 is specially attractive because the safety features need no energy sources and instrumentation in this concept. First approaches for the assessment of the reliability of passively operating systems are summarized. Generally it can be established that the core melt frequency for the passive concepts AP600 and SBWR is advantageous in comparison to the probabilistic objectives from the European Pressurized Water Reactor (EPR). Under the passive concepts is the SWR 600 particularly interesting. In this concept the passive systems need no energy sources and instrumentation, and has active operational systems and active safety equipment. Siemens argues that with this concept the frequency of a core melt will be two orders of magnitude lower than for the conventional reactors. (orig.) [de

  1. Providing Nuclear Criticality Safety Analysis Education through Benchmark Experiment Evaluation

    International Nuclear Information System (INIS)

    Bess, John D.; Briggs, J. Blair; Nigg, David W.

    2009-01-01

    One of the challenges that today's new workforce of nuclear criticality safety engineers face is the opportunity to provide assessment of nuclear systems and establish safety guidelines without having received significant experience or hands-on training prior to graduation. Participation in the International Criticality Safety Benchmark Evaluation Project (ICSBEP) and/or the International Reactor Physics Experiment Evaluation Project (IRPhEP) provides students and young professionals the opportunity to gain experience and enhance critical engineering skills.

  2. 76 FR 76732 - Nominations to the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2011-12-08

    ... individuals will be nominated to the Secretary of HHS for consideration of appointment as members of the ACBSA..., Associate Public Health Advisor for Blood, Organ and Tissue Safety Policy, Department of Health and Human.... Nominations In accordance with the charter, persons nominated for appointment as members of the ACBSA should...

  3. Guide for understanding and evaluation of safety culture

    International Nuclear Information System (INIS)

    2008-01-01

    This report was the guide of understanding and evaluation of safety culture. Operator's activities for enhancement of safety culture in nuclear installations became an object of safety regulation in the management system. Evaluation of operator's activities (including top management's involvement) to prevent degradation of safety culture and organization climate in daily works needed understanding of safety culture and diversity of operator's activities. This guide was prepared to check indications of degradation of safety culture and organization climate in operator's activities in daily works and encourage operator's activities to enhance safety culture improvement and good practice. Comprehensive evaluation of operator's activities to prevent degradation of safety culture and organization climate would be performed from the standpoints of 14 safety culture elements such as top management commitment, clear plan and implementation of upper manager, measures to avoid wrong decision making, questioning attitude, reporting culture, good communications, accountability and openness, compliance, learning system, activities to prevent accidents or incidents beforehand, self-assessment or third party evaluation, work management, change management and attitudes/motivation. Element-wise examples and targets for evaluation were attached with evaluation check tables. (T. Tanaka)

  4. Safety Evaluation of Elderly Laparoscopic Cholecystectomy

    Directory of Open Access Journals (Sweden)

    Bijan Khorasani

    2008-10-01

    Full Text Available Objectives: The most common indication for abdominal surgery in elderly (65 & older is gallstone disease.The elderly are more prone to complication of such surgery due to their other co-morbidity and thus they may benefit mostly from a safer method of surgical procedure. The purpose of this study was to evaluate the safety and outcome of laparoscopic cholecystectomy in elderly compare to the conventional method. Methods & Materials: Via prospective study from June 2005 to March 2008 included all patient older than 60 years of age who underwent cholecystectomy by open (Group A and laparoscopic (Group B method in Milad Hospital.The demographic data (sex age, American Society of Anesthesiologists’ (ASA score, postoperative mortality morbidity, length of stay and operative time were recorded for each patient and were compared between two methods. Data of patient’s analysis by SPSS with chi-square and t test. Results: The study included 311 elderlies (34% men and 66% women. Hundred fifty-seven patients underwent open cholecystectomy; 154 patients underwent laparoscopic cholecystectomy. The mean age was 7141 years. The outcome in group B (laparoscopic included: morality 0%, morbidity 2%, postoperative hospital stay 1 days, mean operation time was 40 minutes. In group A(open: mortality and morbidity rate were 21% and 12% respectively with postoperative hospital stay 331 days and similar operation time as group A. Conclusion: Laparoscopic cholecystectomy is the gold standard treatment and safe procedure in elderly patient and aging is not considered to be a contraindication laparoscopic surgery in such patients.

  5. Health economics and outcomes methods in risk-based decision-making for blood safety.

    Science.gov (United States)

    Custer, Brian; Janssen, Mart P

    2015-08-01

    Analytical methods appropriate for health economic assessments of transfusion safety interventions have not previously been described in ways that facilitate their use. Within the context of risk-based decision-making (RBDM), health economics can be important for optimizing decisions among competing interventions. The objective of this review is to address key considerations and limitations of current methods as they apply to blood safety. Because a voluntary blood supply is an example of a public good, analyses should be conducted from the societal perspective when possible. Two primary study designs are recommended for most blood safety intervention assessments: budget impact analysis (BIA), which measures the cost to implement an intervention both to the blood operator but also in a broader context, and cost-utility analysis (CUA), which measures the ratio between costs and health gain achieved, in terms of reduced morbidity and mortality, by use of an intervention. These analyses often have important limitations because data that reflect specific aspects, for example, blood recipient population characteristics or complication rates, are not available. Sensitivity analyses play an important role. The impact of various uncertain factors can be studied conjointly in probabilistic sensitivity analyses. The use of BIA and CUA together provides a comprehensive assessment of the costs and benefits from implementing (or not) specific interventions. RBDM is multifaceted and impacts a broad spectrum of stakeholders. Gathering and analyzing health economic evidence as part of the RBDM process enhances the quality, completeness, and transparency of decision-making. © 2015 AABB.

  6. 2005 dossier: clay. Tome: safety evaluation of the geologic disposal

    International Nuclear Information System (INIS)

    2005-01-01

    This document makes a status of the researches carried out by the French national agency of radioactive wastes (ANDRA) about the safety aspects of an argilite-type geologic disposal facility for high-level and long-lived (HLLL) radioactive wastes. Content: 1 - safety approach: context and general goals, general safety principles, specificity of the argilite repository safety approach, general approach; 2 - general description: HLLL wastes, geologic context of the Meuse/Haute-Marne site, repository architecture; 3 - safety functions and disposal design: time and space scales, safety approach by functions, functional analysis methodology, analysis of safety functions during the construction, exploitation and observation phases, safety functions analysis during post-closure phase; 4 - operational safety: dosimetric evaluation, risk analysis (explosible gases, fire hazards, lift cage drop, container drop); 5 - long-term efficiency of the disposal facility: normal evolution scenario, from conceptual models to the safety calculation model, description of the safety model, quantitative evaluation of the normal evolution scenario, main lessons learnt from the efficiency analysis; 6 - management of uncertainties: identification, building up of altered situations, mastery of uncertainties; 7 - evaluation of altered evolution scenarios: sealing defect scenario, container defect scenario, drilling scenario, strongly degraded operation scenario; 8 - conclusions: lessons learnt, possible improvements. (J.S.)

  7. Revaluing donor and recipient bodies in the globalised blood economy: transitions in public policy on blood safety in the United Kingdom.

    Science.gov (United States)

    Busby, Helen; Kent, Julie; Farrell, Anne-Maree

    2014-01-01

    The clinical use of blood has a long history, but its apparent stability belies the complexity of contemporary practices in this field. In this article, we explore how the production, supply and deployment of blood products are socially mediated, drawing on theoretical perspectives from recent work on 'tissue economies'. We highlight the ways in which safety threats in the form of infections that might be transmitted through blood and plasma impact on this tissue economy and how these have led to a revaluation of donor bodies and restructuring of blood economies. Specifically, we consider these themes in relation to the management of recent threats to blood safety in the United Kingdom. We show that the tension between securing the supply of blood and its products and ensuring its safety may give rise to ethical concerns and reshape relations between donor and recipient bodies.

  8. Influenza vaccines: Evaluation of the safety profile

    Science.gov (United States)

    Trombetta, Claudia Maria; Gianchecchi, Elena; Montomoli, Emanuele

    2018-01-01

    ABSTRACT The safety of vaccines is a critical factor in maintaining public trust in national vaccination programs. Vaccines are recommended for children, adults and elderly subjects and have to meet higher safety standards, since they are administered to healthy subjects, mainly healthy children. Although vaccines are strictly monitored before authorization, the possibility of adverse events and/or rare adverse events cannot be totally eliminated. Two main types of influenza vaccines are currently available: parenteral inactivated influenza vaccines and intranasal live attenuated vaccines. Both display a good safety profile in adults and children. However, they can cause adverse events and/or rare adverse events, some of which are more prevalent in children, while others with a higher prevalence in adults. The aim of this review is to provide an overview of influenza vaccine safety according to target groups, vaccine types and production methods. PMID:29297746

  9. The impact of WASH-1400 on reactor safety evaluation

    International Nuclear Information System (INIS)

    Tanguy, P.Y.

    1976-01-01

    Trends in reactor safety evaluation in France following the publication of WASH-1400 (the Rasmussen Report) are presented. What is called 'the meteorite case' is first schematically presented as follows: WASH-1400 shows nuclear risk equivalent to meteorite risk and reasonable corrections cannot make many orders of magnitude, consequently present safety rules are adequate. The very impact of WASH-1400 on safety approach is then discussed as for: assistance to deterministic safety analysis, introduction of probabilistic safety criteria, acceptable level of risk, and the use of results in research and reactor operating experience

  10. Systematic safety evaluation of old nuclear power plants

    International Nuclear Information System (INIS)

    Dredemis, G.; Fourest, B.

    1984-01-01

    The French safety authorities have undertaken a systematic evaluation of the safety of old nuclear power plants. Apart from a complete revision of safety documents (safety analysis report, general operating rules, incident and accident procedures, internal emergency plan, quality organisation manual), this examination consisted of analysing the operating experience of systems frequently challenged and a systematic examination of the safety-related systems. This paper is based on an exercise at the Ardennes Nuclear Power Plant which has been in operation for 15 years. This paper also summarizes the main surveys and modifications relating to this power plant. (orig.)

  11. The NHLBI Retrovirus Epidemiology Donor Studies (REDS and REDS-II): Twenty years of research to advance blood product safety and availability

    Science.gov (United States)

    Kleinman, Steven; King, Melissa R; Busch, Michael P; Murphy, Edward L; Glynn, Simone A.

    2012-01-01

    The Retrovirus Epidemiology Donor Study (REDS), conducted from 1989–2001, and the Retrovirus Epidemiology Donor Study-II (REDS-II), conducted from 2004–2012, were National Heart Lung and Blood Institute (NHLBI) funded multicenter programs focused on improving blood safety and availability in the United States. REDS-II also included international study sites in Brazil and China. The three major research domains of REDS/REDS-II have been infectious disease risk evaluation, blood donation availability, and blood donor characterization. Both programs have made significant contributions to transfusion medicine research methodology by the use of mathematical modeling, large-scale donor surveys, innovative methods of repository sample storage, and establishing an infrastructure that responded to potential emerging blood safety threats such as XMRV. Blood safety studies have included protocols evaluating epidemiologic and/or laboratory aspects of HIV, HTLV I/II, HCV, HBV, WNV, CMV, HHV-8, B19V, malaria, CJD, influenza, and T. cruzi infections. Other analyses have characterized: blood donor demographics, motivations to donate, factors influencing donor return, behavioral risk factors, donors’ perception of the blood donation screening process, and aspects of donor deferral. In REDS-II, two large-scale blood donor protocols examined iron deficiency in donors and the prevalence of leukocyte antibodies. This review describes the major study results from over 150 peer-reviewed articles published by these two REDS programs. In 2011, a new seven year program, the Recipient Epidemiology and Donor Evaluation Study-III (REDS-III), was launched. REDS-III expands beyond donor-based research to include studies of blood transfusion recipients in the hospital setting, and adds a third country, South Africa, to the international program. PMID:22633182

  12. Deepening om Safety culture Auto evaluation

    International Nuclear Information System (INIS)

    Lopez Churruca, I.; Buedo Jimenez, J. L.

    2009-01-01

    The concept of safety culture used in nuclear forums refers to the series of actions aimed at guaranteeing that safety issues in nuclear power plants are adequately addressed. The activities to which this concept refers have been gradually extended over the years so that, today, they encompass the whole organizations structure. In other words, the safety culture implies that all positions in the organizational structure perform their tasks with a level of attention such that all their senses are focused on them. And this performance is what leads us to excellence in plant operation. In addition, the implementation of a self-assessment system in the Cofrentes Nuclear Power Plant of its activities and processes has resulted in the identification of expectations on the basis of which we can identify strengths and weaknesses, enabling us to leverage the former and correct the latter. (Author)

  13. Evaluation of safety management in an Appliances manufacturing company

    Directory of Open Access Journals (Sweden)

    F. Golbabaei

    2015-01-01

    Full Text Available Introduction: Prevention of accidents and work related diseases, are not allowed regardless of the safety of employees, customers, contractors and other persons. Assessment of individual safety management activities could reduce many losses. Present study aimed to evaluate the safety management of a household appliance manufacturing company.  .Material and Method: This study has done in a household appliance manufacturing company in Damavand city. Two questionnaires were firstly designed based on the weighted scores. The questionnaire 1 consisted of 4 indicators: Safety of machinery, Electrical safety, Risk assessment and Fire safety. Questionnaire 2 consisted of 11 sub indicators. Both questionnaires were completed by 30 HSE experts and supervisors. Reliability of questionnaires was based on cronbachs alpha coefficient. the safety status of each unit was determined and scored using information acquired by the questionnaires. Lastly, the safety of the entire company was determined.  .Result: Results showed that in safety management: the pressing and store house were in a good range of 66.66 and 60.12 points. Powder painting, enameling, laboratory were in a average range of 56.25, 55.92 and 54.15 points. Assembling and door storage were in a week range of 46.06 points.  .Conclusion: The findings showed that the safety status in the studied appliances company is in average range with 55.45 points. Therefore, it is recommended that the safety indicators should be improved for the betterment of the safety management in the company.

  14. Criticality safety benchmark evaluation project: Recovering the past

    Energy Technology Data Exchange (ETDEWEB)

    Trumble, E.F.

    1997-06-01

    A very brief summary of the Criticality Safety Benchmark Evaluation Project of the Westinghouse Savannah River Company is provided in this paper. The purpose of the project is to provide a source of evaluated criticality safety experiments in an easily usable format. Another project goal is to search for any experiments that may have been lost or contain discrepancies, and to determine if they can be used. Results of evaluated experiments are being published as US DOE handbooks.

  15. Philosophy of safety evaluation on fast breeder reactor

    International Nuclear Information System (INIS)

    1981-01-01

    This is the report submitted from the special subcommittee on reactor safety standard to the Nuclear Safety Commission on October 14, 1980, and it was decided to temporarily apply this concept to the safety examination on fast breeder reactors. The examination and discussion of this report were performed by taking the prototype reactor ''Monju'' into consideration, which is to be the present target, referring to the philosophy of the safety evaluation on fast breeder reactors in foreign countries and based on the experiences in the fast experimental reactor ''Joyo''. The items applicable to the safety evaluation for liquid metal-cooled fast breeder reactors (LMFBR) as they are among the existing safety examination guidelines are applied. In addition to the existing guidelines, the report describes the matters to be considered specifically for core, fuel, sodium, sodium void, reactor shut-down system, reactor coolant boundary, cover gas boundary and others, intermediate cooling system, removal of decay heat, containment vessels, high temperature structures, and aseismatic property in the safety design of LMFBR's. For the safety evaluation for LMFBR's, the abnormal transient changes in operation and the phenomena to be evaluated as accidents are enumerated. In order to judge the propriety of the criteria of locating LMFBR facilities, the serious and hypothetical accidents are decided to be evaluated in accordance with the guideline for reactor location investigation. (Wakatsuki, Y.)

  16. The Evaluation of the Safety Benefits of Combined Passive and On-Board Active Safety Applications

    Science.gov (United States)

    Page, Yves; Cuny, Sophie; Zangmeister, Tobias; Kreiss, Jens-Peter; Hermitte, Thierry

    2009-01-01

    One of the objectives of the European TRACE project (TRaffic Accident Causation in Europe, 2006–2008) was to estimate the proportion of injury accidents that could be avoided and/or the proportion of injury accidents where the severity could be mitigated for on-the-market safety applications, if 100 % of the car fleet would be equipped with them. We have selected for evaluation the Electronic Stability Control (ESC) and the Emergency Brake Assist (EBA) applications. As for passive safety systems, recent cars are designed to offer overall safety protection. Car structure, load limiters, front airbags, side airbags, knee airbags, pretensioners, padding and non aggressive structures in the door panel, the dashboard, the windshield, the seats, and the head rest also contribute to applying more protection. The whole safety package is very difficult to evaluate separately, one element independently segmented from the others. We decided to consider evaluating the effectivenessof the whole passive safety package, This package,, for the sake of simplicity, was the number of stars awarded at the Euro NCAP testing. The challenges were to compare the effectiveness of some safety configuration SC I, with the effectiveness of a different safety configuration SC II. A safety configuration is understood as a package of safety functions. Ten comparisons have been carried out such as the evaluation of the safety benefit of a fifth star given that the car has four stars and an EBA. The main outcome of this analysis is that any addition of a passive or active safety function selected in this analysis is producing increased safety benefits. For example, if all cars were five stars fitted with EBA and ESC, instead of four stars without ESC and EBA, injury accidents would be reduced by 47.2% for severe injuries and 69.5% for fatal injuries. PMID:20184838

  17. A paradigm shift in organisational safety culture evaluation and training

    OpenAIRE

    Cram, Robert; Sime, Julie-Ann

    2015-01-01

    The focus of this research is to explore the issues surrounding traditional approaches towards understanding the safety culture of an organisation operating in a high risk environment and to identify an effective technique to educate corporate management in how to measure and evaluate the underlying safety culture of their own organisations. The results of the first part of the research highlight the concerns being expressed by both academic and industrial communities that current safety cult...

  18. Criticality Safety Evaluation of Hanford Tank Farms Facility

    Energy Technology Data Exchange (ETDEWEB)

    WEISS, E.V.

    2000-12-15

    Data and calculations from previous criticality safety evaluations and analyses were used to evaluate criticality safety for the entire Tank Farms facility to support the continued waste storage mission. This criticality safety evaluation concludes that a criticality accident at the Tank Farms facility is an incredible event due to the existing form (chemistry) and distribution (neutron absorbers) of tank waste. Limits and controls for receipt of waste from other facilities and maintenance of tank waste condition are set forth to maintain the margin subcriticality in tank waste.

  19. Criticality Safety Evaluation of Hanford Tank Farms Facility

    International Nuclear Information System (INIS)

    WEISS, E.V.

    2000-01-01

    Data and calculations from previous criticality safety evaluations and analyses were used to evaluate criticality safety for the entire Tank Farms facility to support the continued waste storage mission. This criticality safety evaluation concludes that a criticality accident at the Tank Farms facility is an incredible event due to the existing form (chemistry) and distribution (neutron absorbers) of tank waste. Limits and controls for receipt of waste from other facilities and maintenance of tank waste condition are set forth to maintain the margin subcriticality in tank waste

  20. A reliability evaluation method for NPP safety DCS application software

    International Nuclear Information System (INIS)

    Li Yunjian; Zhang Lei; Liu Yuan

    2014-01-01

    In the field of nuclear power plant (NPP) digital i and c application, reliability evaluation for safety DCS application software is a key obstacle to be removed. In order to quantitatively evaluate reliability of NPP safety DCS application software, this paper propose a reliability evaluating method based on software development life cycle every stage's v and v defects density characteristics, by which the operating reliability level of the software can be predicted before its delivery, and helps to improve the reliability of NPP safety important software. (authors)

  1. Research on the Evaluation System for Rural Public Safety Planning

    Institute of Scientific and Technical Information of China (English)

    Ming; SUN; Jianxin; YAN

    2014-01-01

    The indicator evaluation system is introduced to the study of rural public safety planning in this article.By researching the current rural public safety planning and environmental carrying capacity,we select some carrying capacity indicators influencing the rural public safety,such as land,population,ecological environment,water resources,infrastructure,economy and society,to establish the environmental carrying capacity indicator system.We standardize the indicators,use gray correlation analysis method to determine the weight of indicators,and make DEA evaluation of the indicator system,to obtain the evaluation results as the basis for decision making in rural safety planning,and provide scientific and quantified technical support for rural public safety planning.

  2. Evaluation of safety practices and performance in a brewery industry ...

    African Journals Online (AJOL)

    Evaluation of safety practices and performance in a brewery industry in Nigeria between 2000 – 2007. ... Journal of Applied Sciences and Environmental Management ... The study revealed that a total of 156 accidents were prevented in the period of the safety programme which translates to an average of 19.45 per year.

  3. Second Meeting for Evaluation of the Nuclear Safety Convention

    International Nuclear Information System (INIS)

    2002-01-01

    This report presents the results of the Second Meeting for Evaluation of the Nuclear Safety Convention. the CSN. as the only competent Government organism on nuclear safety, represented Spain in the preparation of the national report and at the Review Meeting, acquiring a set of obligations for the next three years, until the holding of third meeting. (Author)

  4. Contribution of maintainability and maintenance to problems of safety evaluation

    International Nuclear Information System (INIS)

    Adnot, Serge; Meriaux, Pierre.

    1977-10-01

    A method has been developed for defining the contribution of Maintainability and the Maintenance Studies to Safety evaluation problems. The efficiency of this method is shown and results obtained are given for two theoretical examples approximating reality. For repairable systems, the risk defined according to such given safety criterion, becomes a characteristic of the systems in operation [fr

  5. Evaluation of Four Bedside Test Systems for Card Performance, Handling and Safety.

    Science.gov (United States)

    Giebel, Felix; Picker, Susanne M; Gathof, Birgit S

    2008-01-01

    SUMMARY: OBJECTIVE: Pretransfusion ABO compatibility testing is a simple and required precaution against ABO-incompatible transfusion, which is one of the greatest threats in transfusion medicine. While distinct agglutination is most important for correct test interpretation, protection against infectious diseases and ease of handling are crucial for accurate test performance. Therefore, the aim of this study was to evaluate differences in test card design, handling, and user safety. DESIGN: Four different bedside test cards with pre-applied antibodies were evaluated by 100 medical students using packed red blood cells of different ABO blood groups. Criteria of evaluation were: agglutination, labelling, handling, and safety regarding possible user injuries. Criteria were rated subjectively according to German school notes ranging from 1 = very good to 6 = very bad/insufficient. RESULTS: Overall, all cards received very good/good marks. The ABO blood group was identified correctly in all cases. Three cards (no. 1, no. 3, no. 4) received statistically significant (p labelling (1.5 vs. 2.2-2.4), handling (1.9-2.0 vs. 2.5), and user safety (2.5 vs. 3.4). Analysis of card self-explanation revealed no remarkable differences. CONCLUSION: Despite good performance of all card systems tested, the best results when including all criteria evaluated were obtained with card no. 4 (particularly concerning clear agglutination), followed by cards no. 2, no. 1, and no. 3.

  6. Uncertainty analysis for Ulysses safety evaluation report

    International Nuclear Information System (INIS)

    Frank, M.V.

    1991-01-01

    As part of the effort to review the Ulysses Final Safety Analysis Report and to understand the risk of plutonium release from the Ulysses spacecraft General Purpose Heat Source---Radioisotope Thermal Generator (GPHS-RTG), the Interagency Nuclear Safety Review Panel (INSRP) and the author performed an integrated, quantitative analysis of the uncertainties of the calculated risk of plutonium release from Ulysses. Using state-of-art probabilistic risk assessment technology, the uncertainty analysis accounted for both variability and uncertainty of the key parameters of the risk analysis. The results show that INSRP had high confidence that risk of fatal cancers from potential plutonium release associated with calculated launch and deployment accident scenarios is low

  7. Evaluation of reliability assurance approaches to operational nuclear safety

    International Nuclear Information System (INIS)

    Mueller, C.J.; Bezella, W.A.

    1984-01-01

    This report discusses the results of research to evaluate existing and/or recommended safety/reliability assurance activities among nuclear and other high technology industries for potential nuclear industry implementation. Since the Three Mile Island (TMI) accident, there has been increased interest in the use of reliability programs (RP) to assure the performance of nuclear safety systems throughout the plant's lifetime. Recently, several Nuclear Regulatory Commission (NRC) task forces or safety issue review groups have recommended RPs for assuring the continuing safety of nuclear reactor plants. 18 references

  8. An evaluation of the uranium mine radiation safety course

    International Nuclear Information System (INIS)

    1984-07-01

    The report evaluates the Uranium Mine Radiation Safety Course focussing on the following areas: effectivenss of the course; course content; instructional quality; course administration. It notes strengths and weaknesses in these areas and offers preliminary recommendations for future action

  9. CRITICALITY SAFETY LIMIT EVALUATION PROGRAM (CSLEP's) AND QUICK SCREENS: ANSWERS TO EXPEDITED PROCESSING LEGACY CRITICALITY SAFETY LIMITS AND EVALUATIONS

    International Nuclear Information System (INIS)

    TOFFER, H.

    2006-01-01

    Since the end of the cold war, the need for operating weapons production facilities has faded. Criticality Safety Limits and controls supporting production modes in these facilities became outdated and furthermore lacked the procedure based rigor dictated by present day requirements. In the past, in many instances, the formalism of present day criticality safety evaluations was not applied. Some of the safety evaluations amounted to a paragraph in a notebook with no safety basis and questionable arguments with respect to double contingency criteria. When material stabilization, clean out, and deactivation activities commenced, large numbers of these older criticality safety evaluations were uncovered with limits and controls backed up by tenuous arguments. A dilemma developed: on the one hand, cleanup activities were placed on very aggressive schedules; on the other hand, a highly structured approach to limits development was required and applied to the cleanup operations. Some creative approaches were needed to cope with the limits development process

  10. Nuclear criticality safety parameter evaluation for uranium metallic alloy

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, Andrea; Abe, Alfredo, E-mail: andreasdpz@hotmail.com, E-mail: abye@uol.com.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil). Centro de Energia Nuclear

    2013-07-01

    Nuclear criticality safety during fuel fabrication process, transport and storage of fissile and fissionable materials requires criticality safety analysis. Normally the analysis involves computer calculations and safety parameters determination. There are many different Criticality Safety Handbooks where such safety parameters for several different fissile mixtures are presented. The handbooks have been published to provide data and safety principles for the design, safety evaluation and licensing of operations, transport and storage of fissile and fissionable materials. The data often comprise not only critical values, but also subcritical limits and safe parameters obtained for specific conditions using criticality safety calculation codes such as SCALE system. Although many data are available for different fissile and fissionable materials, compounds, mixtures, different enrichment level, there are a lack of information regarding a uranium metal alloy, specifically UMo and UNbZr. Nowadays uranium metal alloy as fuel have been investigated under RERTR program as possible candidate to became a new fuel for research reactor due to high density. This work aim to evaluate a set of criticality safety parameters for uranium metal alloy using SCALE system and MCNP Monte Carlo code. (author)

  11. A tool for safety evaluations of road improvements.

    Science.gov (United States)

    Peltola, Harri; Rajamäki, Riikka; Luoma, Juha

    2013-11-01

    Road safety impact assessments are requested in general, and the directive on road infrastructure safety management makes them compulsory for Member States of the European Union. However, there is no widely used, science-based safety evaluation tool available. We demonstrate a safety evaluation tool called TARVA. It uses EB safety predictions as the basis for selecting locations for implementing road-safety improvements and provides estimates of safety benefits of selected improvements. Comparing different road accident prediction methods, we demonstrate that the most accurate estimates are produced by EB models, followed by simple accident prediction models, the same average number of accidents for every entity and accident record only. Consequently, advanced model-based estimates should be used. Furthermore, we demonstrate regional comparisons that benefit substantially from such tools. Comparisons between districts have revealed significant differences. However, comparisons like these produce useful improvement ideas only after taking into account the differences in road characteristics between areas. Estimates on crash modification factors can be transferred from other countries but their benefit is greatly limited if the number of target accidents is not properly predicted. Our experience suggests that making predictions and evaluations using the same principle and tools will remarkably improve the quality and comparability of safety estimations. Copyright © 2013 Elsevier Ltd. All rights reserved.

  12. The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): A research program striving to improve blood donor and transfusion recipient outcomes

    Science.gov (United States)

    Kleinman, Steven; Busch, Michael P; Murphy, Edward L; Shan, Hua; Ness, Paul; Glynn, Simone A.

    2014-01-01

    Background The Recipient Epidemiology and Donor Evaluation Study -III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute. Study design The domestic component involves 4 blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa which involve US and in-country investigators. Results REDS-III is using two major methods to address key research priorities in blood banking/transfusion medicine. First, there will be numerous analyses of large “core” databases; the international programs have each constructed a donor/donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Secondly, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that are either in progress or scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization; transfusion outcomes; non-infectious transfusion risks; HIV-related safety issues (particularly in the international programs); emerging infectious agents; blood component quality; donor health and safety; and other donor issues. Conclusions It is intended that REDS-III serve as an impetus for more widespread recipient and linked donor-recipient research in the US as well as to help assure a safe and available blood supply in the US and in international locations. PMID:24188564

  13. Packaging Evaluation Approach to Improve Cosmetic Product Safety

    OpenAIRE

    Benedetta Briasco; Priscilla Capra; Arianna Cecilia Cozzi; Barbara Mannucci; Paola Perugini

    2016-01-01

    In the Regulation 1223/2009, evaluation of packaging has become mandatory to assure cosmetic product safety. In fact, the safety assessment of a cosmetic product can be successfully carried out only if the hazard deriving from the use of the designed packaging for the specific product is correctly evaluated. Despite the law requirement, there is too little information about the chemical-physical characteristics of finished packaging and the possible interactions between formulation and packag...

  14. An evaluation of the use of blood metabolite concentrations as ...

    African Journals Online (AJOL)

    The aim of this study was to determine whether blood metabolite concentrations in free-ranging indigenous goats are sensitive to expected variations in nutrient supply, and whether they could be used to evaluate different kidding seasons at two locations subject to similar seasonal variations in terms of nutrient supply.

  15. Safety evaluation on irradiated food ingestion

    International Nuclear Information System (INIS)

    1986-01-01

    This paper reports double-blind observations of volunteers who took 35 kinds of irradiated foods as their main diet for 90 days. The subjects consisted of 70 medical students and 8 staff members in the Shanghai Medical University. They were randomly divided into two groups. One group was supplied with irradiated foods, the other acted as controls eating the same food but non-irradiated. The 35 kinds of irradiated foods were grain, meat products, vegetables, fruits, dried fruits etc. The absorbed dose of irradiation from the processed foods varied from 0.1 to 8.0 kGy. The irradiated foods made up 60.3% of the total food intake by weight. Observations during 90 days indicated that the subjects were all pleased with their diets and no adverse effects on their health were seen. Clinical and laboratory examinations included routine blood and urine tests, blood biochemical examinations, hepatic and renal function tests, endocrinological assays, cellular immunity tests, and mutagenetic studies (such as the incidence of polyploid cells, chromosomal structural aberration, rates of sister chromatid-exchanges, micronuclei test, urine Ames' test). These studies showed that the ingestion of these foods are safe for humans

  16. Evaluating safety-critical organizations - emphasis on the nuclear industry

    Energy Technology Data Exchange (ETDEWEB)

    Reiman, Teemu; Oedewald, Pia (VTT, Technical Research Centre of Finland (Finland))

    2009-04-15

    An organizational evaluation plays a key role in the monitoring, as well as controlling and steering, of the organizational safety culture. If left unattended, organizations have a tendency to gradually drift into a condition where they have trouble identifying their vulnerabilities and mechanisms or practices that create or maintain these vulnerabilities. The aim of an organizational evaluation should be to promote increased understanding of the sociotechnical system and its changing vulnerabilities. Evaluation contributes to organizational development and management. Evaluations are used in various situations, but when the aim is to learn about possible new vulnerabilities, identify organizational reasons for problems, or prepare for future challenges, the organization is most open to genuine surprises and new findings. It is recommended that organizational evaluations should be conducted when - there are changes in the organizational structures - new tools are implemented - when the people report increased workplace stress or a decreased working climate - when incidents and near-misses increase - when work starts to become routine - when weak signals (such as employees voicing safety concerns or other worries, the organization 'feels' different, organizational climate has changed) are perceived. In organizations that already have a high safety level, safety managers work for their successors. This means that they seldom see the results of their successful efforts to improve safety. This is due to the fact that it takes time for the improvement to become noticeable in terms of increased measurable safety levels. The most challenging issue in an organizational evaluation is the definition of criteria for safety. We have adopted a system safety perspective and we state that an organization has a high potential for safety when - safety is genuinely valued and the members of the organization are motivated to put effort on achieving high levels of safety

  17. Evaluating safety-critical organizations - emphasis on the nuclear industry

    International Nuclear Information System (INIS)

    Reiman, Teemu; Oedewald, Pia

    2009-04-01

    An organizational evaluation plays a key role in the monitoring, as well as controlling and steering, of the organizational safety culture. If left unattended, organizations have a tendency to gradually drift into a condition where they have trouble identifying their vulnerabilities and mechanisms or practices that create or maintain these vulnerabilities. The aim of an organizational evaluation should be to promote increased understanding of the sociotechnical system and its changing vulnerabilities. Evaluation contributes to organizational development and management. Evaluations are used in various situations, but when the aim is to learn about possible new vulnerabilities, identify organizational reasons for problems, or prepare for future challenges, the organization is most open to genuine surprises and new findings. It is recommended that organizational evaluations should be conducted when - there are changes in the organizational structures - new tools are implemented - when the people report increased workplace stress or a decreased working climate - when incidents and near-misses increase - when work starts to become routine - when weak signals (such as employees voicing safety concerns or other worries, the organization 'feels' different, organizational climate has changed) are perceived. In organizations that already have a high safety level, safety managers work for their successors. This means that they seldom see the results of their successful efforts to improve safety. This is due to the fact that it takes time for the improvement to become noticeable in terms of increased measurable safety levels. The most challenging issue in an organizational evaluation is the definition of criteria for safety. We have adopted a system safety perspective and we state that an organization has a high potential for safety when - safety is genuinely valued and the members of the organization are motivated to put effort on achieving high levels of safety - it is

  18. An evaluation of asymptomatic Dengue infections among blood donors during the 2014 Dengue outbreak in Guangzhou, China.

    Science.gov (United States)

    Liao, Qiao; Shan, Zhengang; Wang, Min; Huang, Jieting; Xu, Ru; Huang, Ke; Tang, Xi; Zhang, Weiyun; Nelson, Kenrad; Li, Chengyao; Fu, Yongshui; Rong, Xia

    2017-11-01

    In 2014, an outbreak of dengue virus (DENV) infection led to 45 171 clinical cases diagnosed in Guangdong province, Southern China. However, the potential risk of blood donors asymptomatically infected with DENV has not been evaluated . In the current study we detected anti-DENV IgG antibody and RNA in volunteer Chinese blood donors. We found that anti-DENV IgG antibody was positively detected in 3.4% (51/1500) and two donors were detected as being DENV RNA positive out of 3000 blood samples. We concluded that the presence of potential DENV in blood donors might be potential risk for blood safety. Therefore, screening for DENV infection should be considered in blood donations during a period of dengue outbreak in high epidemic area of China. © 2017 Wiley Periodicals, Inc.

  19. Evaluation for nuclear safety-critical software reliability of DCS

    International Nuclear Information System (INIS)

    Liu Ying

    2015-01-01

    With the development of control and information technology at NPPs, software reliability is important because software failure is usually considered as one form of common cause failures in Digital I and C Systems (DCS). The reliability analysis of DCS, particularly qualitative and quantitative evaluation on the nuclear safety-critical software reliability belongs to a great challenge. To solve this problem, not only comprehensive evaluation model and stage evaluation models are built in this paper, but also prediction and sensibility analysis are given to the models. It can make besement for evaluating the reliability and safety of DCS. (author)

  20. Plasma fractionation, a useful means to improve national transfusion system and blood safety: Iran experience.

    Science.gov (United States)

    Cheraghali, A M; Abolghasemi, H

    2009-03-01

    In 1974, the government of Iran established Iranian Blood Transfusion Organization (IBTO) as national and centralized transfusion system. Since then donations of blood may not be remunerated and therapy with blood and its components are free of charges for all Iranian patients. Donations are meticulously screened through interviewing donors and lab testing the donations using serological methods. Currently, Iranian donors donate 1735 00 units of blood annually (donation index: 25/1000 population). Implementation of a highly efficient donor selection programme, including donors interview, establishment of confidential unit exclusion programme and laboratory screening of donated bloods by IBTO have led to seroprevalence rates of 0.41%, 0.12% and 0.004% for HBV, HCV and HIV in donated bloods respectively. Since 2004, IBTO has initiated a programme to enter into a contract fractionation agreement for the surplus of recovered plasma produced in its blood collecting centres. Although IBTO has used this project as a mean to improve national transfusion system through upgrading its quality assurance systems, IBTO fractionation project has played a major role in improving availability of plasma-derived medicines in Iran. During 2006-2007, this project furnished the Iran market with 44% and 14% of its needs to the intravenous immunoglobulin and albumin, respectively. Iranian experience showed that contract fractionation of plasma in countries with organized centralized transfusion system, which lack national plasma fractionation facility, in addition to substantial saving on national health resource and enhancing availability of plasma-derived medicines, could serve as a useful means to improve national blood safety profile.

  1. Body fat and blood rheology: Evaluation of the association between different adiposity indices and blood viscosity.

    Science.gov (United States)

    Tripolino, Cesare; Irace, Concetta; Carallo, Claudio; Scavelli, Faustina Barbara; Gnasso, Agostino

    2017-01-01

    In recent years, new measures of body adiposity have been introduced: lipid accumulation product (LAP), body adiposity index (BAI) and body shape index (ABSI). These indices have been demonstrated to better associate with cardiovascular disease than other measures of adiposity. The aim of the present study was to evaluate if LAP or BAI better associate with blood viscosity than other measures of adiposity (body mass index, BMI; waist circumference, WC; waist-to-hip ratio, W/HR; waist-to-height ratio, W/HtR). 344 subjects were recruited for the present investigation. Exclusion criteria were: diabetes, elevated triglycerides, smoking and drug use. Blood lipids and glucose were measured by routine methods. Blood and plasma viscosity were measured by a cone-plate viscometer. Adiposity measures were computed as previously described. In simple correlation analyses, blood viscosity (BV) correlated with BMI, BAI, and LAP in males and with LAP in females. Correlations between plasma viscosity and adiposity indices were weak and not statistically significant. Other variables significantly related with BV were: gender, HDL- and LDL-Cholesterol, and triglycerides (p index is strongly associated to blood viscosity. This result, along with previous evidence, identifies LAP index as a potential cardiovascular risk marker.

  2. Development of safety analysis technology for integral reactor; evaluation on safety concerns of integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hee Chul; Kim, Woong Sik; Lee, J. H. [Korea Institute of Nuclear Safety, Taejeon (Korea)

    2002-03-01

    The Nuclear Desalination Plant (NDP) is being developed to produce electricity and fresh water, and is expected to locate near population zone. In the aspect of safety, it is required to protect the public and environment from the possible releases of fission products and to prevent the fresh water from the contamination of radioactivity. Thus, in this study, the safety characteristics of the integral reactor adopting passive and inherent safety features significantly different from existing nuclear power plants were investigated. Also, safety requirements applicable to the NDP were analyzed based on the regulatory requirements for current light water reactor and advanced reactor designs, and user requirements for small-medium size reactors. Based on these analyses, some safety concerns to be considered in the design stage have been identified and discussed. They include the use of proven technology for new safety features, systematic event classification and selection, strengthening containment function, and the safety impacts on desalination-related systems. The study presents the general safety requirements applicable to licensing of an integral reactor and suggests additional regulatory requirements, which need to be developed, based on the direction to resolution of the safety concerns. The efforts to identify and technically resolve the safety concerns in the design stage will provide the early confidence of SMART safety and the technical basis to evaluate the safety to designers and reviewers in the future. Suggestion on the development of additional regulatory requirements will contribute for the regulator to taking actions for licensing of an integral reactor. 66 refs., 5 figs., 24 tabs. (Author)

  3. Human immunodeficiency virus prevalence, incidence, and residual transmission risk in first-time and repeat blood donations in Zimbabwe: implications on blood safety.

    Science.gov (United States)

    Mapako, Tonderai; Mvere, David A; Chitiyo, McLeod E; Rusakaniko, Simbarashe; Postma, Maarten J; van Hulst, Marinus

    2013-10-01

    National Blood Service Zimbabwe human immunodeficiency virus (HIV) risk management strategy includes screening and discarding of first-time donations, which are collected in blood packs without an anticoagulant (dry pack). To evaluate the impact of discarding first-time donations on blood safety the HIV prevalence, incidence, and residual risk in first-time and repeat donations (wet packs) were compared. Donor data from 2002 to 2010 were retrieved from a centralized national electronic donor database and retrospectively analyzed. Chi-square test was used to compare HIV prevalence with relative risk (RR), and the RR point estimates and 95% confidence interval (CI) are reported. Trend analysis was done using Cochran-Armitage trend test. HIV residual risk estimates were determined using published residual risk estimation models. Over the 9 years the overall HIV prevalence estimates are 1.29% (n = 116,058) and 0.42% (n = 434,695) for first-time and repeat donations, respectively. The overall RR was 3.1 (95% CI, 2.9-3.3; p donations in first-time was 1:7384 (range, 1:11,308-1:5356) and in repeat donors it was 1:5496 (range, 1:9943-1:3347). The significantly high HIV prevalence estimates recorded in first-time over repeat donations is indicative of the effectiveness of the HIV risk management strategy. However, comparable residual transmission risk estimates in first-time and repeat donors point to the need to further review the risk management strategies. Given the potential wastage of valuable resources, future studies should focus on the cost-effectiveness and utility of screening and discarding first-time donations. © 2013 American Association of Blood Banks.

  4. Lead evaluation in blood of workers of batteries industries

    International Nuclear Information System (INIS)

    Valbuena P, John J; Duarte, Martha; Marciales Clara

    2001-01-01

    In order to evaluate the occupational risk of exposure to lead of employees working in three small industries that recycle and manufacture acid lead batteries, the lead and zinc protoporphyrine (ZPP) blood content was determined. The determination was also performed on people not exposed in order to establish comparison values. Venous blood was collected in metal free heparinized glass tubes. Lead was analyzed by atomic absorption with graphite furnace and ZPP by fluorescence. According to Colombian legislation, it was found that around 31 % workers in this type of industries are in dangerous and intoxication exposure. It was also found that 91 % of workers exceed the level of 30 mg Pb/dL blood established as standard by the American Conference governmental Industrial Hygienists (ACGIH)

  5. Utilizing Radiofrequency Identification Technology to Improve Safety and Management of Blood Bank Supply Chains.

    Science.gov (United States)

    Coustasse, Alberto; Meadows, Pamela; Hall, Robert S; Hibner, Travis; Deslich, Stacie

    2015-11-01

    The importance of efficiency in the supply chain of perishable products, such as the blood products used in transfusion services, cannot be overstated. Many problems can occur, such as the outdating of products, inventory management issues, patient misidentification, and mistransfusion. The purpose of this article was to identify the benefits and barriers associated with radiofrequency identification (RFID) usage in improving the blood bank supply chain. The methodology for this study was a qualitative literature review following a systematic approach. The review was limited to sources published from 2000 to 2014 in the English language. Sixty-five sources were found, and 56 were used in this research study. According to the finding of the present study, there are numerous benefits and barriers to RFID utilization in blood bank supply chains. RFID technology offers several benefits with regard to blood bank product management, including decreased transfusion errors, reduction of product loss, and more efficient inventory management. Barriers to RFID implementation include the cost associated with system implementation and patient privacy issues. Implementation of an RFID system can be a significant investment. However, when observing the positive impact that such systems may have on transfusion safety and inventory management, the cost associated with RFID systems can easily be justified. RFID in blood bank inventory management is vital to ensuring efficient product inventory management and positive patient outcomes.

  6. Safety evaluation of a hydrogen fueled transit bus

    Energy Technology Data Exchange (ETDEWEB)

    Coutts, D.A.; Thomas, J.K.; Hovis, G.L.; Wu, T.T. [Westinghouse Savannah River Co., Aiken, SC (United States)

    1997-12-31

    Hydrogen fueled vehicle demonstration projects must satisfy management and regulator safety expectations. This is often accomplished using hazard and safety analyses. Such an analysis has been completed to evaluate the safety of the H2Fuel bus to be operated in Augusta, Georgia. The evaluation methods and criteria used reflect the Department of Energy`s graded approach for qualifying and documenting nuclear and chemical facility safety. The work focused on the storage and distribution of hydrogen as the bus motor fuel with emphases on the technical and operational aspects of using metal hydride beds to store hydrogen. The safety evaluation demonstrated that the operation of the H2Fuel bus represents a moderate risk. This is the same risk level determined for operation of conventionally powered transit buses in the United States. By the same criteria, private passenger automobile travel in the United States is considered a high risk. The evaluation also identified several design and operational modifications that resulted in improved safety, operability, and reliability. The hazard assessment methodology used in this project has widespread applicability to other innovative operations and systems, and the techniques can serve as a template for other similar projects.

  7. Occupational safety of different industrial sectors in Khartoum State, Sudan. Part 1: Safety performance evaluation.

    Science.gov (United States)

    Zaki, Gehan R; El-Marakby, Fadia A; H Deign El-Nor, Yasser; Nofal, Faten H; Zakaria, Adel M

    2012-12-01

    Safety performance evaluation enables decision makers improve safety acts. In Sudan, accident records, statistics, and safety performance were not evaluated before maintenance of accident records became mandatory in 2005. This study aimed at evaluating and comparing safety performance by accident records among different cities and industrial sectors in Khartoum state, Sudan, during the period from 2005 to 2007. This was a retrospective study, the sample in which represented all industrial enterprises in Khartoum state employing 50 workers or more. All industrial accident records of the Ministry of Manpower and Health and those of different enterprises during the period from 2005 to 2007 were reviewed. The safety performance indicators used within this study were the frequency-severity index (FSI) and fatal and disabling accident frequency rates (DAFR). In Khartoum city, the FSI [0.10 (0.17)] was lower than that in Bahari [0.11 (0.21)] and Omdurman [0.84 (0.34)]. It was the maximum in the chemical sector [0.33 (0.64)] and minimum in the metallurgic sector [0.09 (0.19)]. The highest DAFR was observed in Omdurman [5.6 (3.5)] and in the chemical sector [2.5 (4.0)]. The fatal accident frequency rate in the mechanical and electrical engineering industry was the highest [0.0 (0.69)]. Male workers who were older, divorced, and had lower levels of education had the lowest safety performance indicators. The safety performance of the industrial enterprises in Khartoum city was the best. The safety performance in the chemical sector was the worst with regard to FSI and DAFR. The age, sex, and educational level of injured workers greatly affect safety performance.

  8. FLIGHT SAFETY MANAGEMENT PROBLEMS AND EVALUATION OF FLIGHT SAFETY LEVEL OF AN AVIATION ENTERPRISE

    Directory of Open Access Journals (Sweden)

    B. V. Zubkov

    2017-01-01

    Full Text Available This article is devoted to studying the problem of safety management system (SMS and evaluating safety level of an aviation enterprise.This article discusses the problems of SMS, presented at the 41st meeting of the Russian Aviation Production Commanders Club in June 2014 in St. Petersburg in connection with the verification of the status of the CA of the Russian Federation by the International Civil Aviation Organization (ICAO in the same year, a set of urgent measures to eliminate the deficiencies identified in the current safety management system by participants of this meeting were proposed.In addition, the problems of evaluating flight safety level based on operation data of an aviation enterprise were analyzed. This analysis made it possible to take into account the problems listed in this article as a tool for a comprehensive study of SMS parameters and allows to analyze the quantitative indicators of the flights safety level.The concepts of Acceptable Safety Level (ASL indicators are interpreted differently depending on the available/applicable methods of their evaluation and how to implement them in SMS. However, the indicators for assessing ASL under operational condition at the aviation enterprise should become universal. Currently, defined safety levels and safety indicators are not yet established functionally and often with distorted underrepresented models describing their contextual contents, as well as ways of integrating them into SMS aviation enterprise.The results obtained can be used for better implementation of SMS and solving problems determining the aviation enterprise technical level of flight safety.

  9. Safety performance evaluation using proactive indicators in a selected industry

    Directory of Open Access Journals (Sweden)

    Abolfazl Barkhordari

    2015-03-01

    Full Text Available Background & Objectives: Quality and effectiveness of safety systems are critical factors in achieving their goals. This study was aimed to represent a method for performance evaluation of safety systems by proactive indicators using different updated models in the field of safety which will be tested in a selected industry. Methods: This study is a cross-sectional study. Proactive indicators used in this study were: Unsafe acts rate, Safety Climate, Accident Proneness, and Near-miss incident rate. The number of in 1473 safety climate questionnaires and 543 Accident Proneness questionnaires was completed. Results: The minimum and maximum safety climate score were 56.88 and 58.2, respectively, and the minimum and maximum scores of Accident Proneness were 98.2 and 140.7, respectively. The maximum number of Near-miss incident rate were 408 and the minimum of that was 196. The maximum number of unsafe acts rate was 43.8 percent and the minimum of that was 27.2 percent. In nine dimensions of Safety climate the eighth dimension (personal perception of risk with the score of 4.07 has the lowest score and the fourth (laws and safety regulations dimension with 8.05 has the highest score. According to expert opinions, the most important indicator in the assessment of safety performance was unsafe acts rate, while near-miss incident rate was the least important one. Conclusion: The results of this survey reveal that using proactive (Prospective indicators could be an appropriate method in organizations safety performance evaluation.

  10. Evaluation of atmospheric dispersion/consequence models supporting safety analysis

    International Nuclear Information System (INIS)

    O'Kula, K.R.; Lazaro, M.A.; Woodard, K.

    1996-01-01

    Two DOE Working Groups have completed evaluation of accident phenomenology and consequence methodologies used to support DOE facility safety documentation. The independent evaluations each concluded that no one computer model adequately addresses all accident and atmospheric release conditions. MACCS2, MATHEW/ADPIC, TRAC RA/HA, and COSYMA are adequate for most radiological dispersion and consequence needs. ALOHA, DEGADIS, HGSYSTEM, TSCREEN, and SLAB are recommended for chemical dispersion and consequence applications. Additional work is suggested, principally in evaluation of new models, targeting certain models for continued development, training, and establishing a Web page for guidance to safety analysts

  11. An Evaluation Tool for Agricultural Health and Safety Mobile Applications.

    Science.gov (United States)

    Reyes, Iris; Ellis, Tammy; Yoder, Aaron; Keifer, Matthew C

    2016-01-01

    As the use of mobile devices and their software applications, or apps, becomes ubiquitous, use amongst agricultural working populations is expanding as well. The smart device paired with a well-designed app has potential for improving workplace health and safety in the hands of those who can act upon the information provided. Many apps designed to assess workplace hazards and implementation of worker protections already exist. However, the abundance and diversity of such applications also presents challenges regarding evaluation practices and assignation of value. This is particularly true in the agricultural workspace, as there is currently little information on the value of these apps for agricultural safety and health. This project proposes a framework for developing and evaluating apps that have potential usefulness in agricultural health and safety. The evaluation framework is easily transferable, with little modification for evaluation of apps in several agriculture-specific areas.

  12. Safety Evaluation of Osun River Water Containing Heavy Metals and ...

    African Journals Online (AJOL)

    Summary: This study evaluated the pH, heavy metals and volatile organic compounds (VOCs) in Osun river water. It also evaluated its safety in rats. Heavy metals were determined by atomic absorption spectrophotometry (AAS) while VOCs were determined by gas chromatography coupled with flame ionization detector ...

  13. Expert evaluation in NPP safety important systems licensing process

    International Nuclear Information System (INIS)

    Mikhail, A Yastrebenetsky; Vasilchenko, V.N.

    2001-01-01

    Expert evaluation of nuclear power plant safety important systems modernization is an integral part of these systems licensing process. The paper contains some aspects of this evaluation which are based on Ukrainian experience of VVER-1000 and VVER-440 modernization. (authors)

  14. Expert evaluation in NPP safety important systems licensing process

    Energy Technology Data Exchange (ETDEWEB)

    Mikhail, A Yastrebenetsky; Vasilchenko, V.N. [Ukrainian State Scientific Technical Center of Nuclear and Radiation Safety (Ukraine)

    2001-07-01

    Expert evaluation of nuclear power plant safety important systems modernization is an integral part of these systems licensing process. The paper contains some aspects of this evaluation which are based on Ukrainian experience of VVER-1000 and VVER-440 modernization. (authors)

  15. Analytic choices in road safety evaluation

    DEFF Research Database (Denmark)

    Elvik, Rune

    2012-01-01

    -of-the-art approaches. This paper explores the implications of choice of study design by examining how the findings of several evaluation studies made in Norway depend on choices made with respect to: 1. Using the empirical Bayes approach versus using simpler approaches; 2. Use or non-use of a comparison group; 3...

  16. FLIGHT SAFETY MANAGEMENT PROBLEMS AND EVALUATION OF FLIGHT SAFETY LEVEL OF AN AVIATION ENTERPRISE

    OpenAIRE

    B. V. Zubkov; H. E. Fourar

    2017-01-01

    This article is devoted to studying the problem of safety management system (SMS) and evaluating safety level of an aviation enterprise.This article discusses the problems of SMS, presented at the 41st meeting of the Russian Aviation Production Commanders Club in June 2014 in St. Petersburg in connection with the verification of the status of the CA of the Russian Federation by the International Civil Aviation Organization (ICAO) in the same year, a set of urgent measures to eliminate the def...

  17. Forum for debate: Safety of allogeneic blood transfusion alternatives in the surgical/critically ill patient.

    Science.gov (United States)

    Muñoz Gómez, M; Bisbe Vives, E; Basora Macaya, M; García Erce, J A; Gómez Luque, A; Leal-Noval, S R; Colomina, M J; Comin Colet, J; Contreras Barbeta, E; Cuenca Espiérrez, J; Garcia de Lorenzo Y Mateos, A; Gomollón García, F; Izuel Ramí, M; Moral García, M V; Montoro Ronsano, J B; Páramo Fernández, J A; Pereira Saavedra, A; Quintana Diaz, M; Remacha Sevilla, Á; Salinas Argente, R; Sánchez Pérez, C; Tirado Anglés, G; Torrabadella de Reinoso, P

    2015-12-01

    In recent years, several safety alerts have questioned or restricted the use of some pharmacological alternatives to allogeneic blood transfusion in established indications. In contrast, there seems to be a promotion of other alternatives, based on blood products and/or antifibrinolytic drugs, which lack a solid scientific basis. The Multidisciplinary Autotransfusion Study Group and the Anemia Working Group España convened a multidisciplinary panel of 23 experts belonging to different healthcare areas in a forum for debate to: 1) analyze the different safety alerts referred to certain transfusion alternatives; 2) study the background leading to such alternatives, the evidence supporting them, and their consequences for everyday clinical practice, and 3) issue a weighted statement on the safety of each questioned transfusion alternative, according to its clinical use. The members of the forum maintained telematics contact for the exchange of information and the distribution of tasks, and a joint meeting was held where the conclusions on each of the items examined were presented and discussed. A first version of the document was drafted, and subjected to 4 rounds of review and updating until consensus was reached (unanimously in most cases). We present the final version of the document, approved by all panel members, and hope it will be useful for our colleagues. Copyright © 2015 Elsevier España, S.L.U. and SEMICYUC. All rights reserved.

  18. Economic evaluation in patient safety: a literature review of methods.

    Science.gov (United States)

    de Rezende, Bruna Alves; Or, Zeynep; Com-Ruelle, Laure; Michel, Philippe

    2012-06-01

    Patient safety practices, targeting organisational changes for improving patient safety, are implemented worldwide but their costs are rarely evaluated. This paper provides a review of the methods used in economic evaluation of such practices. International medical and economics databases were searched for peer-reviewed publications on economic evaluations of patient safety between 2000 and 2010 in English and French. This was complemented by a manual search of the reference lists of relevant papers. Grey literature was excluded. Studies were described using a standardised template and assessed independently by two researchers according to six quality criteria. 33 articles were reviewed that were representative of different patient safety domains, data types and evaluation methods. 18 estimated the economic burden of adverse events, 3 measured the costs of patient safety practices and 12 provided complete economic evaluations. Healthcare-associated infections were the most common subject of evaluation, followed by medication-related errors and all types of adverse events. Of these, 10 were selected that had adequately fulfilled one or several key quality criteria for illustration. This review shows that full cost-benefit/utility evaluations are rarely completed as they are resource intensive and often require unavailable data; some overcome these difficulties by performing stochastic modelling and by using secondary sources. Low methodological transparency can be a problem for building evidence from available economic evaluations. Investing in the economic design and reporting of studies with more emphasis on defining study perspectives, data collection and methodological choices could be helpful for strengthening our knowledge base on practices for improving patient safety.

  19. [Comics for traffic education: evaluation of a traffic safety campaign].

    Science.gov (United States)

    Bonfadelli, H

    1989-01-01

    Traffic safety campaigns often are ineffective to change driving behavior because they don't reach the target group or are recognized only by people who are already interested or concerned. The evaluation of a traffic safety campaign called "Leo Lässig", addressed to young new drivers, shows that recognition and acceptance by the target group were stimulated by the age-conform means of comic-strips.

  20. Blood transfusion exposure in Denmark and Sweden

    DEFF Research Database (Denmark)

    Kamper-Jørgensen, Mads; Edgren, Gustaf; Rostgaard, Klaus

    2009-01-01

    Although essential for the evaluation of blood transfusion safety, the prevalence of blood transfusion in the general population is not presently known. This study estimated the exposure to blood transfusion in the general Scandinavian population.......Although essential for the evaluation of blood transfusion safety, the prevalence of blood transfusion in the general population is not presently known. This study estimated the exposure to blood transfusion in the general Scandinavian population....

  1. Safety indicators as a tool for operational safety evaluation of nuclear power plants

    International Nuclear Information System (INIS)

    Araujo, Jefferson Borges; Melo, Paulo Fernando Ferreira Frutuoso e; Schirru, Roberto

    2009-01-01

    Performance indicators have found a wide use in the conventional and nuclear industries. For the conventional industry, the goal is to optimize production, reducing loss of time with accidents, human error and equipment downtimes. In the nuclear industry, nuclear safety is an additional goal. This paper presents a general methodology to the establishment, selection and use of safety indicators for a two loop PWR plant, as Angra 1. The use of performance indicators is not new. The NRC has its own methodology and the IAEA presents methodology suggestions, but there is no detailed documentation about indicators selection, criteria and bases used. Additionally, only the NRC methodology performs a limited integrated evaluation. The study performed identifies areas considered critical for the plant operational safety. For each of these areas, strategic sub-areas are defined. For each strategic sub-area, specific safety indicators are defined. These proposed Safety Indicators are based on the contribution to risk considering a quantitative risk analysis. For each safety indicator, a goal, a bounded interval and proper bases are developed, to allow for a clear and comprehensive individual behavior evaluation. On the establishment of the intervals and boundaries, a probabilistic safety study, operational experience, international and national standards and technical specifications were used. Additionally, an integrated evaluation of the indicators, using expert systems, was done to obtain an overview of the plant general safety. This evaluation uses well-defined and clear rules and weights for each indicator to be considered. These rules were implemented by means of a computational language, on a friendly interface, so that it is possible to obtain a quick response about operational safety. This methodology can be used to identify situations where the plant safety is challenged, by giving a general overview of the plant operational condition. Additionally, this study can

  2. Reactor safety; Description and evaluation of safety activities in Nordic countries

    International Nuclear Information System (INIS)

    Wahlstroem, B.; Gunsell, L.

    1998-03-01

    The report gives a description of safety activities in the nuclear power industry. The study has been carried out as a part of the four year programme in Nordic Safety Research (NKS) which was completed in 1997. The objective of the NKS/RAK-1.1 project 'A survey and an evaluation of safety activities in nuclear power' was to make a broad description of various activities important for safety and to make an assessment of their efficiency. A special consideration was placed on a comparison of practices in Finland and Sweden, and between their nuclear utilities. The study has been divided into two parts, one theoretical part in which a model of the relationships between various activities important for safety has been constructed and one practical part where a total of 62 persons have been interviewed at the authorities, the nuclear utilities and one reactor vendor. To restrict the amount of work two activities, safety analysis and experience feedback, were selected. A few cases connected to incidents at nuclear power plants were discussed in more detail. The report has been structured around a simple model of nuclear safety consisting of the concepts of goals, means and outcomes. This model illustrates the importance of goal formulation, systematic planning and feedback of operational experience as major components in nuclear safety. In assessing organisation and management at authorities and the power utilities there is a clear trend of decentralisation and delegation of authority. The general impression from the study is that the safety activities in Finland and Sweden are efficient and well targeted. The experience from the methodology is favourable and the comparison of practices gives a good ground for a discussion of contents and targeting of safety activities. (EG) activities. (EG)

  3. A quantitative approach to safety evaluation

    International Nuclear Information System (INIS)

    Kuz'min, I.I.; Romanov, S.V.; Chernoplekov, A.N.; Babaev, N.S.

    1984-01-01

    The paper evaluates the hazards associated with an increase in the CO 2 concentration of the atmosphere and an accompanying rise in average annual temperature at ground level. For the calculations, a global model developed in 1971 by D. Forrestor, which takes ecological factors into account, was used. The main hazards associated with an increase in temperature at ground level as a result of an increase in the CO 2 concentration are possible agricultural losses in the form of smaller harvests. This type of hazard is evaluated in the paper by means of the global development model. Two alternatives were considered: in the first, losses are assumed to be offset by additional capital investment in agriculture, while in the second the same money is spent on reducing CO 2 releases. It is shown that a diversion of funds to the construction of purification systems might lead to a crisis as a result of reduced standards of living and a corresponding rise in mortality. In the paper it is assumed that a reduction in the coefficient of mortality can be taken as a criterion of safe development. (author)

  4. Aging evaluation methodology of periodic safety review in Korea

    International Nuclear Information System (INIS)

    Park, Heung-Bae; Jung, Sung-Gyu; Jin, Tae-Eun; Jeong, Ill-Seok

    2002-01-01

    In Korea plant lifetime management (PLIM) study for Kori Unit 1 has been performed since 1993. Meanwhile, periodic safety review (PSR) for all operating nuclear power plants (NPPs) has been started with Kori Unit 1 since 2000 per IAEA recommendation. The evaluation period is 10 years, and safety (evaluation) factors are 11 per IAEA guidelines as represented in table 1. The relationship between PSR factors and PLIM is also represented. Among these factors evaluation of 'management of aging' is one of the most important and difficult factor. This factor is related to 'actual condition of the NPP', 'use of experience from other nuclear NPPs and of research findings', and 'management of aging'. The object of 'management of aging' is to obtain plant safety through identifying actual condition of system, structure and components (SSCs) and evaluating aging phenomena and residual life of SSCs using operating experience and research findings. The paper describes the scope and procedure of valuation of 'management of aging', such as, screening criteria of SSCs, Code and Standards, evaluation of SSCs and safety issues as represented. Evaluating SSCs are determined using final safety analysis report (FSAR) and power unit maintenance system for Nuclear Ver. III (PUMAS/N-III). The screening criteria of SSCs are safety-related items (quality class Q), safety-impact items (quality class T), backfitting rule items (fire protection (10CFR50.48), environmental qualification (10CFR50.49), pressurized thermal shock (10CFR50.61), anticipated transient without scram (10CFR50.62), and station blackout (10CFR50.63)) and regulating authority requiring items[1∼3]. The purpose of review of Code and Standards is identifying actual condition of the NPP and evaluating aging management using effective Code and Standards corresponding to reactor facilities. Code and Standards is composed of regulating laws, FSAR items, administrative actions, regulating actions, agreement items, and other

  5. The International Criticality Safety Benchmark Evaluation Project (ICSBEP)

    International Nuclear Information System (INIS)

    Briggs, J.B.

    2003-01-01

    The International Criticality Safety Benchmark Evaluation Project (ICSBEP) was initiated in 1992 by the United States Department of Energy. The ICSBEP became an official activity of the Organisation for Economic Cooperation and Development (OECD) - Nuclear Energy Agency (NEA) in 1995. Representatives from the United States, United Kingdom, France, Japan, the Russian Federation, Hungary, Republic of Korea, Slovenia, Yugoslavia, Kazakhstan, Israel, Spain, and Brazil are now participating. The purpose of the ICSBEP is to identify, evaluate, verify, and formally document a comprehensive and internationally peer-reviewed set of criticality safety benchmark data. The work of the ICSBEP is published as an OECD handbook entitled 'International Handbook of Evaluated Criticality Safety Benchmark Experiments.' The 2003 Edition of the Handbook contains benchmark model specifications for 3070 critical or subcritical configurations that are intended for validating computer codes that calculate effective neutron multiplication and for testing basic nuclear data. (author)

  6. International Criticality Safety Benchmark Evaluation Project (ICSBEP) - ICSBEP 2015 Handbook

    International Nuclear Information System (INIS)

    Bess, John D.

    2015-01-01

    The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United States Department of Energy (DOE). The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) became an official activity of the Nuclear Energy Agency (NEA) in 1995. This handbook contains criticality safety benchmark specifications that have been derived from experiments performed at various critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculation techniques used to establish minimum subcritical margins for operations with fissile material and to determine criticality alarm requirements and placement. Many of the specifications are also useful for nuclear data testing. Example calculations are presented; however, these calculations do not constitute a validation of the codes or cross-section data. The evaluated criticality safety benchmark data are given in nine volumes. These volumes span approximately 69000 pages and contain 567 evaluations with benchmark specifications for 4874 critical, near-critical or subcritical configurations, 31 criticality alarm placement/shielding configurations with multiple dose points for each, and 207 configurations that have been categorised as fundamental physics measurements that are relevant to criticality safety applications. New to the handbook are benchmark specifications for neutron activation foil and thermoluminescent dosimeter measurements performed at the SILENE critical assembly in Valduc, France as part of a joint venture in 2010 between the US DOE and the French Alternative Energies and Atomic Energy Commission (CEA). A photograph of this experiment is shown on the front cover. Experiments that are found unacceptable for use as criticality safety benchmark experiments are discussed in these

  7. Evaluation of seismic hazards for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2002-01-01

    The main objective of this Safety Guide is to provide recommendations on how to determine the ground motion hazards for a plant at a particular site and the potential for surface faulting, which could affect the feasibility of construction and safe operation of a plant at that site. The guidelines and procedures presented in this Safety Guide can appropriately be used in evaluations of site suitability and seismic hazards for nuclear power plants in any seismotectonic environment. The probabilistic seismic hazard analysis recommended in this Safety Guide also addresses the needs for seismic hazard analysis of external event PSAs conducted for nuclear power plants. Many of the methods and processes described may also be applicable to nuclear facilities other than power plants. Other phenomena of permanent ground displacement (liquefaction, slope instability, subsidence and collapse) as well as the topic of seismically induced flooding are treated in Safety Guides relating to foundation safety and coastal flooding. Recommendations of a general nature are given in Section 2. Section 3 discusses the acquisition of a database containing the information needed to evaluate and address all hazards associated with earthquakes. Section 4 covers the use of this database for construction of a seismotectonic model. Sections 5 and 6 review ground motion hazards and evaluations of the potential for surface faulting, respectively. Section 7 addresses quality assurance in the evaluation of seismic hazards for nuclear power plants

  8. Potassium evaluation in blood of Brazilian athletes using NAA

    Energy Technology Data Exchange (ETDEWEB)

    Kovacs, L.; Zamboni, C.B. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Nunes, L.A.S.; Lourenco, T.F.; Macedo, D. Vaz de [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)

    2010-07-01

    Full text: According to nutrition sources an athlete needs per day at least one gram of potassium for keeping the correct mineral balance in the organism. Its deficiency or even instantaneous low concentration in blood can diminish the athlete performance originating nervous irritability, muscular weakness, and mental disorientation and in more several causes cardiac arrhythmias. In this study the K levels in blood were determined in athletes submitted to constant load exercise at treadmill at LABEX (Laboratorio de Bioquimica do Exercicio - UNICAMP, Brazil) using Neutron Activation Analyses (NAA). The blood samples were collected from male athletes, age 18 to 26 years, before and after the physical training. Immediately after the collection an amount of 10 micro liters of whole blood was transferred to the filter paper and dried for a few minutes using an infrared lamp. To determine the concentration of potassium each sample was irradiated in the nuclear reactor (IEA-R1, 2-4MW, pool type) at IPEN and was gamma counted using an HPGe Spectrometer of High Energy Resolution. The concentrations of the selected element, 1525keV related to the potassium activated {sup 42}K, were calculated using in -house software. The potassium levels were evaluated before and after the physical exercise and the data were compared with the normal range. (author)

  9. Potassium evaluation in blood of Brazilian athletes using NAA

    International Nuclear Information System (INIS)

    Kovacs, L.; Zamboni, C.B.; Nunes, L.A.S.; Lourenco, T.F.; Macedo, D. Vaz de

    2010-01-01

    Full text: According to nutrition sources an athlete needs per day at least one gram of potassium for keeping the correct mineral balance in the organism. Its deficiency or even instantaneous low concentration in blood can diminish the athlete performance originating nervous irritability, muscular weakness, and mental disorientation and in more several causes cardiac arrhythmias. In this study the K levels in blood were determined in athletes submitted to constant load exercise at treadmill at LABEX (Laboratorio de Bioquimica do Exercicio - UNICAMP, Brazil) using Neutron Activation Analyses (NAA). The blood samples were collected from male athletes, age 18 to 26 years, before and after the physical training. Immediately after the collection an amount of 10 micro liters of whole blood was transferred to the filter paper and dried for a few minutes using an infrared lamp. To determine the concentration of potassium each sample was irradiated in the nuclear reactor (IEA-R1, 2-4MW, pool type) at IPEN and was gamma counted using an HPGe Spectrometer of High Energy Resolution. The concentrations of the selected element, 1525keV related to the potassium activated 42 K, were calculated using in -house software. The potassium levels were evaluated before and after the physical exercise and the data were compared with the normal range. (author)

  10. Patient involvement in blood transfusion safety: patients' and healthcare professionals' perspective.

    Science.gov (United States)

    Davis, R; Murphy, M F; Sud, A; Noel, S; Moss, R; Asgheddi, M; Abdur-Rahman, I; Vincent, C

    2012-08-01

    Blood transfusion is one of the major areas where serious clinical consequences, even death, related to patient misidentification can occur. In the UK, healthcare professional compliance with pre-transfusion checking procedures which help to prevent misidentification errors is poor. Involving patients at a number of stages in the transfusion pathway could help prevent the occurrence of these incidents. To investigate patients' willingness to be involved and healthcare professionals' willingness to support patient involvement in pre-transfusion checking behaviours. A cross-sectional design was employed assessing willingness to participate in pre-transfusion checking behaviours (patient survey) and willingness to support patient involvement (healthcare professional survey) on a scale of 1-7. One hundred and ten patients who had received a transfusion aged between 18 and 93 (60 male) and 123 healthcare professionals (doctors, nurses and midwives) involved in giving blood transfusions to patients. Mean scores for patients' willingness to participate in safety-relevant transfusion behaviours and healthcare professionals' willingness to support patient involvement ranged from 4.96-6.27 to 4.53-6.66, respectively. Both groups perceived it most acceptable for patients to help prevent errors or omissions relating to their hospital identification wristband. Neither prior experience of receiving a blood transfusion nor professional role of healthcare staff had an effect on attitudes towards patient participation. Overall, both patients and healthcare professionals view patient involvement in transfusion-related behaviours quite favourably and appear in agreement regarding the behaviours patients should adopt an active role in. Further work is needed to determine the effectiveness of this approach to improve transfusion safety. © 2012 The Authors. Transfusion Medicine © 2012 British Blood Transfusion Society.

  11. FFTF railroad tank car Safety Evaluation for Packaging

    International Nuclear Information System (INIS)

    Carlstrom, R.F.

    1995-01-01

    This Safety Evaluation for Packaging (SEP) provides evaluations considered necessary to approve transfer of the 8,000 gallon Liquid Waste Tank Car (LWTC) from Fast Flux Test Facility (FFTF) to the 200 Areas. This SEP will demonstrate that the transfer of the LWTC will provide an equivalent degree of safety as would be provided by packages meeting U.S. Department of Transportation (DOT) requirements. This fulfills onsite transportation requirements implemented in the Hazardous Material Packaging and Shipping, WHC-CM-2-14

  12. Criticality Safety Evaluation for the TACS at DAF

    Energy Technology Data Exchange (ETDEWEB)

    Percher, C. M. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States); Heinrichs, D. P. [Lawrence Livermore National Lab. (LLNL), Livermore, CA (United States)

    2011-06-10

    Hands-on experimental training in the physical behavior of multiplying systems is one of ten key areas of training required for practitioners to become qualified in the discipline of criticality safety as identified in DOE-STD-1135-99, Guidance for Nuclear Criticality Safety Engineer Training and Qualification. This document is a criticality safety evaluation of the training activities and operations associated with HS-3201-P, Nuclear Criticality 4-Day Training Course (Practical). This course was designed to also address the training needs of nuclear criticality safety professionals under the auspices of the NNSA Nuclear Criticality Safety Program1. The hands-on, or laboratory, portion of the course will utilize the Training Assembly for Criticality Safety (TACS) and will be conducted in the Device Assembly Facility (DAF) at the Nevada Nuclear Security Site (NNSS). The training activities will be conducted by Lawrence Livermore National Laboratory following the requirements of an Integrated Work Sheet (IWS) and associated Safety Plan. Students will be allowed to handle the fissile material under the supervision of an LLNL Certified Fissile Material Handler.

  13. Safety analysis and evaluation methodology for fusion systems

    International Nuclear Information System (INIS)

    Fujii-e, Y.; Kozawa, Y.; Namba, C.

    1987-03-01

    Fusion systems which are under development as future energy systems have reached a stage that the break even is expected to be realized in the near future. It is desirable to demonstrate that fusion systems are well acceptable to the societal environment. There are three crucial viewpoints to measure the acceptability, that is, technological feasibility, economy and safety. These three points have close interrelation. The safety problem is more important since three large scale tokamaks, JET, TFTR and JT-60, start experiment, and tritium will be introduced into some of them as the fusion fuel. It is desirable to establish a methodology to resolve the safety-related issues in harmony with the technological evolution. The promising fusion system toward reactors is not yet settled. This study has the objective to develop and adequate methodology which promotes the safety design of general fusion systems and to present a basis for proposing the R and D themes and establishing the data base. A framework of the methodology, the understanding and modeling of fusion systems, the principle of ensuring safety, the safety analysis based on the function and the application of the methodology are discussed. As the result of this study, the methodology for the safety analysis and evaluation of fusion systems was developed. New idea and approach were presented in the course of the methodology development. (Kako, I.)

  14. Criticality safety evaluations - a open-quotes stalking horseclose quotes for integrated safety assessment

    International Nuclear Information System (INIS)

    Williams, R.A.

    1995-01-01

    The Columbia Fuel Fabrication Facility of the Westinghouse Commercial Nuclear Fuel Division manufactures low-enriched uranium fuel and associated components for use in commercial pressurized water power reactors. To support development of a comprehensive integrated safety assessment (ISA) for the facility, as well as to address increasing U.S. Nuclear Regulatory Commission (NRC) expectations regarding such a facility's criticality safety assessments, a project is under way to complete criticality safety evaluations (CSEs) of all plant systems used in processing nuclear materials. Each CSE is made up of seven sections, prepared by a multidisciplinary team of process engineers, systems engineers, safety engineers, maintenance representatives, and operators. This paper provides a cursory outline of the type of information presented in a CSE

  15. Criticality safety evaluations - a {open_quotes}stalking horse{close_quotes} for integrated safety assessment

    Energy Technology Data Exchange (ETDEWEB)

    Williams, R.A. [Westinghouse Electric Corp., Columbia, SC (United States)

    1995-12-31

    The Columbia Fuel Fabrication Facility of the Westinghouse Commercial Nuclear Fuel Division manufactures low-enriched uranium fuel and associated components for use in commercial pressurized water power reactors. To support development of a comprehensive integrated safety assessment (ISA) for the facility, as well as to address increasing U.S. Nuclear Regulatory Commission (NRC) expectations regarding such a facility`s criticality safety assessments, a project is under way to complete criticality safety evaluations (CSEs) of all plant systems used in processing nuclear materials. Each CSE is made up of seven sections, prepared by a multidisciplinary team of process engineers, systems engineers, safety engineers, maintenance representatives, and operators. This paper provides a cursory outline of the type of information presented in a CSE.

  16. A bicycle safety index for evaluating urban street facilities.

    Science.gov (United States)

    Asadi-Shekari, Zohreh; Moeinaddini, Mehdi; Zaly Shah, Muhammad

    2015-01-01

    The objectives of this research are to conceptualize the Bicycle Safety Index (BSI) that considers all parts of the street and to propose a universal guideline with microscale details. A point system method comparing existing safety facilities to a defined standard is proposed to estimate the BSI. Two streets in Singapore and Malaysia are chosen to examine this model. The majority of previous measurements to evaluate street conditions for cyclists usually cannot cover all parts of streets, including segments and intersections. Previous models also did not consider all safety indicators and cycling facilities at a microlevel in particular. This study introduces a new concept of a practical BSI to complete previous studies using its practical, easy-to-follow, point system-based outputs. This practical model can be used in different urban settings to estimate the level of safety for cycling and suggest some improvements based on the standards.

  17. A Guidebook for Evaluating Organizations in the Nuclear Industry - an example of safety culture evaluation

    International Nuclear Information System (INIS)

    Oedewald, Pia; Pietikaeinen, Elina; Reiman, Teemu

    2011-06-01

    Organizations in the nuclear industry need to maintain an overview on their vulnerabilities and strengths with respect to safety. Systematic periodical self assessments are necessary to achieve this overview. This guidebook provides suggestions and examples to assist power companies but also external evaluators and regulators in carrying out organizational evaluations. Organizational evaluation process is divided into five main steps. These are: 1) planning the evaluation framework and the practicalities of the evaluation process, 2) selecting data collection methods and conducting the data acquisition, 3) structuring and analysing the data, 4) interpreting the findings and 5) reporting the evaluation results with possible recommendations. The guidebook emphasises the importance of a solid background framework when dealing with multifaceted phenomena like organisational activities and system safety. The validity and credibility of the evaluation stem largely from the evaluation team's ability to crystallize what they mean by organization and safety when they conduct organisational safety evaluations - and thus, what are the criteria for the evaluation. Another important and often under-considered phase in organizational evaluation is interpretation of the findings. In this guidebook a safety culture evaluation in a Nordic nuclear power plant is presented as an example of organizational evaluation. With the help of the example, challenges of each step in the organizational evaluation process are described. Suggestions for dealing with them are presented. In the case example, the DISC (Design for Integrated Safety culture) model is used as the evaluation framework. The DISC model describes the criteria for a good safety culture and the organizational functions necessary to develop a good safety culture in the organization

  18. Development of evaluation method for software safety analysis techniques

    International Nuclear Information System (INIS)

    Huang, H.; Tu, W.; Shih, C.; Chen, C.; Yang, W.; Yih, S.; Kuo, C.; Chen, M.

    2006-01-01

    Full text: Full text: Following the massive adoption of digital Instrumentation and Control (I and C) system for nuclear power plant (NPP), various Software Safety Analysis (SSA) techniques are used to evaluate the NPP safety for adopting appropriate digital I and C system, and then to reduce risk to acceptable level. However, each technique has its specific advantage and disadvantage. If the two or more techniques can be complementarily incorporated, the SSA combination would be more acceptable. As a result, if proper evaluation criteria are available, the analyst can then choose appropriate technique combination to perform analysis on the basis of resources. This research evaluated the applicable software safety analysis techniques nowadays, such as, Preliminary Hazard Analysis (PHA), Failure Modes and Effects Analysis (FMEA), Fault Tree Analysis (FTA), Markov chain modeling, Dynamic Flowgraph Methodology (DFM), and simulation-based model analysis; and then determined indexes in view of their characteristics, which include dynamic capability, completeness, achievability, detail, signal/ noise ratio, complexity, and implementation cost. These indexes may help the decision makers and the software safety analysts to choose the best SSA combination arrange their own software safety plan. By this proposed method, the analysts can evaluate various SSA combinations for specific purpose. According to the case study results, the traditional PHA + FMEA + FTA (with failure rate) + Markov chain modeling (without transfer rate) combination is not competitive due to the dilemma for obtaining acceptable software failure rates. However, the systematic architecture of FTA and Markov chain modeling is still valuable for realizing the software fault structure. The system centric techniques, such as DFM and Simulation-based model analysis, show the advantage on dynamic capability, achievability, detail, signal/noise ratio. However, their disadvantage are the completeness complexity

  19. Evaluation of the Finnish nuclear safety research program 'SAFIR2010'

    International Nuclear Information System (INIS)

    2010-01-01

    A panel of three members has been asked by the Ministry of Employment and the Economy (MEE) to evaluate SAFIR2010, the Finnish research program on nuclear power plant safety. The program was established for the period 2007-2010 to help maintain expertise in nuclear safety, to integrate young people into the research in order to help assure the future availability of expertise, and to support international collaborations. The program is directed by a Steering Group, appointed by MEE, with representatives from all organizations involved with nuclear safety in Finland. SAFIR2010 has consisted of approximately 30 projects from year to year that fall into eight subject areas: 1. Organization and human factors 2. Automation and control room 3. Fuel and reactor physics 4. Thermal hydraulics 5. Severe accidents 6. Structural safety of reactor circuit 7. Construction safety 8. Probabilistic safety analysis (PSA) For each of these areas there are Reference Groups that provide oversight of the projects within their jurisdiction. The panel carried out its evaluation by reviewing copies of relevant documents and, during a one-week period 17-22 January 2010, meeting with key individuals. The results of the panel are provided as general conclusions, responses to questions posed by MEE, challenges and recommendations and comments on specific projects in each subject area. The general conclusions reflect the panel's view that SAFIR2010 is meeting its objectives and carrying out quality research. The questions addressed are: (a.) Are the achieved results in balance with the funding? Are the results exploited efficiently in practice? (b.) How well does the expertise cover the field? Is the entire SAFIR2010 programme balanced to all different fields in nuclear safety? Does it raise efficiently new experts? (c.) Have the 2006 evaluation results been implemented successfully into SAFIR2010 program? (d.) Challenges and recommendations. In general the panel was very positive about SAFIR

  20. Emerging Infectious Diseases and Blood Safety: Modeling the Transfusion-Transmission Risk.

    Science.gov (United States)

    Kiely, Philip; Gambhir, Manoj; Cheng, Allen C; McQuilten, Zoe K; Seed, Clive R; Wood, Erica M

    2017-07-01

    While the transfusion-transmission (TT) risk associated with the major transfusion-relevant viruses such as HIV is now very low, during the last 20 years there has been a growing awareness of the threat to blood safety from emerging infectious diseases, a number of which are known to be, or are potentially, transfusion transmissible. Two published models for estimating the transfusion-transmission risk from EIDs, referred to as the Biggerstaff-Petersen model and the European Upfront Risk Assessment Tool (EUFRAT), respectively, have been applied to several EIDs in outbreak situations. We describe and compare the methodological principles of both models, highlighting their similarities and differences. We also discuss the appropriateness of comparing results from the two models. Quantitating the TT risk of EIDs can inform decisions about risk mitigation strategies and their cost-effectiveness. Finally, we present a qualitative risk assessment for Zika virus (ZIKV), an EID agent that has caused several outbreaks since 2007. In the latest and largest ever outbreak, several probable cases of transfusion-transmission ZIKV have been reported, indicating that it is transfusion-transmissible and therefore a risk to blood safety. We discuss why quantitative modeling the TT risk of ZIKV is currently problematic. Crown Copyright © 2017. Published by Elsevier Inc. All rights reserved.

  1. The International Criticality Safety Benchmark Evaluation Project on the Internet

    International Nuclear Information System (INIS)

    Briggs, J.B.; Brennan, S.A.; Scott, L.

    2000-01-01

    The International Criticality Safety Benchmark Evaluation Project (ICSBEP) was initiated in October 1992 by the US Department of Energy's (DOE's) defense programs and is documented in the Transactions of numerous American Nuclear Society and International Criticality Safety Conferences. The work of the ICSBEP is documented as an Organization for Economic Cooperation and Development (OECD) handbook, International Handbook of Evaluated Criticality Safety Benchmark Experiments. The ICSBEP Internet site was established in 1996 and its address is http://icsbep.inel.gov/icsbep. A copy of the ICSBEP home page is shown in Fig. 1. The ICSBEP Internet site contains the five primary links. Internal sublinks to other relevant sites are also provided within the ICSBEP Internet site. A brief description of each of the five primary ICSBEP Internet site links is given

  2. Evaluating an Entertainment–Education Telenovela to Promote Workplace Safety

    Directory of Open Access Journals (Sweden)

    Diego E. Castaneda

    2013-08-01

    Full Text Available Occupational safety and health professionals worked with health communication experts to collaborate with a major Spanish language television network to develop and implement a construction workplace safety media intervention targeting Latino/Hispanic audiences. An Entertainment–Education (EE health communication strategy was used to create a worksite safety storyline weaved into the main plot of a nationally televised Telenovela (Spanish language soap opera. A secondary analysis of audience survey data in a pre/posttest cross-sectional equivalent group design was performed to evaluate the effectiveness of this EE media intervention to change knowledge, attitudes, and intention outcomes related to the prevention of fatal falls at construction worksites. Results indicate that using culturally relevant mediums can be an effective way of reaching and educating audiences about specific fall prevention information. This is aligned with recommendations by the Institute of Medicine (IOM to increase interventions and evaluations of culturally relevant and competent health communication.

  3. Evaluating Performance of Safety Management and Occupational Health Using Total Quality Safety Management Model (TQSM

    Directory of Open Access Journals (Sweden)

    E Mohammadfam

    2015-11-01

    Full Text Available Introduction: All organizations, whether public or private, necessitate performance evaluation systems in regard with growth, stability, and development in the competitive fields. One of the existing models for performance evaluation of occupational health and safety management is Total Quality Safety Management model (TQSM. Therefore, the present study aimed to evaluate performance of safety management and occupational health utilizing TQSM model. Methods: In this descriptive-analytic study, the population consisted of 16 individuals, including managers, supervisors, and members of technical protection and work health committee. Then the participants were asked to respond to TQSM questionnaire before and after the implementation of Occupational Health & Safety Advisory Services 18001 (OHSAS18001. Ultimately, the level of each program as well as the TQSM status were determined before and after the implementation of OHSAS18001. Results: The study results showed that the scores obtained by the company before OHSAS 18001’s implementation, was 43.7 out of 312. After implementing OHSAS 18001 in the company and receiving the related certificate, the total score of safety program that company could obtain was 127.12 out of 312 demonstrating a rise of 83.42 scores (26.8%. The paired t-test revealed that mean difference of TQSM scores before and after OHSAS 18001 implementation was proved to be significant (p> 0.05. Conclusion: The study findings demonstrated that TQSM can be regarded as an appropriate model in order to monitor the performance of safety management system and occupational health, since it possesses the ability to quantitatively evaluate the system performance.

  4. Systematic evaluation of candidate blood markers for detecting ovarian cancer.

    Directory of Open Access Journals (Sweden)

    Chana Palmer

    2008-07-01

    Full Text Available Epithelial ovarian cancer is a significant cause of mortality both in the United States and worldwide, due largely to the high proportion of cases that present at a late stage, when survival is extremely poor. Early detection of epithelial ovarian cancer, and of the serous subtype in particular, is a promising strategy for saving lives. The low prevalence of ovarian cancer makes the development of an adequately sensitive and specific test based on blood markers very challenging. We evaluated the performance of a set of candidate blood markers and combinations of these markers in detecting serous ovarian cancer.We selected 14 candidate blood markers of serous ovarian cancer for which assays were available to measure their levels in serum or plasma, based on our analysis of global gene expression data and on literature searches. We evaluated the performance of these candidate markers individually and in combination by measuring them in overlapping sets of serum (or plasma samples from women with clinically detectable ovarian cancer and women without ovarian cancer. Based on sensitivity at high specificity, we determined that 4 of the 14 candidate markers--MUC16, WFDC2, MSLN and MMP7--warrant further evaluation in precious serum specimens collected months to years prior to clinical diagnosis to assess their utility in early detection. We also reported differences in the performance of these candidate blood markers across histological types of epithelial ovarian cancer.By systematically analyzing the performance of candidate blood markers of ovarian cancer in distinguishing women with clinically apparent ovarian cancer from women without ovarian cancer, we identified a set of serum markers with adequate performance to warrant testing for their ability to identify ovarian cancer months to years prior to clinical diagnosis. We argued for the importance of sensitivity at high specificity and of magnitude of difference in marker levels between cases and

  5. Construction of Earthquake-Proof Safety Evaluation Methods for Pipes with Wall Thinning

    International Nuclear Information System (INIS)

    Miyano, Hiroshi; Sekimura, Naoto; Takizawa, Masayuki; Matsumoto, Masaaki

    2012-01-01

    After the accident at the Fukushima Daiichi Nuclear Power Plant, the extreme importance of 'system safety' evaluation has been recognized. In this study, some fundamental ways of thinking about the concept of 'system safety' for operating plants is shown, and concrete evaluation structures of system safety are proposed. System safety for nuclear power plants and safety assessment for aging plants are constructed. (author)

  6. Safety evaluation of a conceptual fuel recycle complex

    International Nuclear Information System (INIS)

    Hodges, M.E.

    1980-01-01

    A conceptual design integration study for an integrated Fuel Recycle Complex (FRC) has been completed. A safety evaluation of the radiation shielding, fire precautions, handling of nonradioactive hazardous materials, criticality hazards, operating errors, and the influence of natural phenomena on the FRC shows that all federal regulations are met or exceeded

  7. Evaluation of pesticide safety measures adopted by potato farmers ...

    African Journals Online (AJOL)

    In order to increase productivity and quality, farmers use pesticides and other agrochemicals. These pesticides if improperly handled impact negatively on the health of the users. The objective of the study was to evaluate the pesticide safety measures adopted by potato farmers in Chebiemit Division of Elgeyo/Marakwet ...

  8. Safety evaluation of substituted thiophenes used as flavoring ingredients

    NARCIS (Netherlands)

    Cohen, Samuel M.; Fukushima, Shoji; Gooderham, Nigel J.; Guengerich, F.P.; Hecht, Stephen S.; Rietjens, Ivonne M.C.M.; Smith, Robert L.; Bastaki, Maria; Harman, Christie L.; McGowen, Margaret M.; Valerio, Luis G.; Taylor, Sean V.

    2017-01-01

    This publication is the second in a series by the Expert Panel of the Flavor and Extract Manufacturers Association summarizing the conclusions of its third systematic re-evaluation of the safety of flavorings previously considered to be generally recognized as safe (GRAS) under conditions of

  9. Recommendations for preparing the criticality safety evaluation of transportation packages

    International Nuclear Information System (INIS)

    Dyer, H.R.; Parks, C.V.

    1997-04-01

    This report provides recommendations on preparing the criticality safety section of an application for approval of a transportation package containing fissile material. The analytical approach to the evaluation is emphasized rather than the performance standards that the package must meet. Where performance standards are addressed, this report incorporates the requirements of 10 CFR Part 71. 12 refs., 6 figs., 8 tabs

  10. Evaluation and Customization of WHO Safety Checklist for Patient Safety in Otorhinolaryngology.

    Science.gov (United States)

    Dabholkar, Yogesh; Velankar, Haritosh; Suryanarayan, Sneha; Dabholkar, Twinkle Y; Saberwal, Akanksha A; Verma, Bhavika

    2018-03-01

    The WHO has designed a safe surgery checklist to enhance communication and awareness of patient safety during surgery and to minimise complications. WHO recommends that the check-list be evaluated and customised by end users as a tool to promote safe surgery. The aim of present study was to evaluate the impact of WHO safety checklist on patient safety awareness in otorhinolaryngology and to customise it for the speciality. A prospective structured questionnaire based study was done in ENT operating room for duration of 1 month each for cases, before and after implementation of safe surgery checklist. The feedback from respondents (surgeons, nurses and anaesthetists) was used to arrive at a customised checklist for otolaryngology as per WHO guidelines. The checklist significantly improved team member's awareness of patient's identity (from 17 to 86%) and each other's identity and roles (from 46 to 94%) and improved team communication (from 73 to 92%) in operation theatre. There was a significant improvement in preoperative check of equipment and critical events were discussed more frequently. The checklist could be effectively customised to suit otolaryngology needs as per WHO guidelines. The modified checklist needs to be validated by otolaryngology associations. We conclude from our study that the WHO Surgical safety check-list has a favourable impact on patient safety awareness, team-work and communication of operating team and can be customised for otolaryngology setting.

  11. Safety Evaluation for Packaging (onsite) T Plant Canyon Items

    International Nuclear Information System (INIS)

    OBRIEN, J.H.

    2000-01-01

    This safety evaluation for packaging (SEP) evaluates and documents the ability to safely ship mostly unique inventories of miscellaneous T Plant canyon waste items (T-P Items) encountered during the canyon deck clean off campaign. In addition, this SEP addresses contaminated items and material that may be shipped in a strong tight package (STP). The shipments meet the criteria for onsite shipments as specified by Fluor Hanford in HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments

  12. Evaluation of safety-parameter display concepts. Final report

    International Nuclear Information System (INIS)

    Woods, D.D.; Wise, J.A.; Hanes, L.F.

    1982-02-01

    New control room equipment designed to improve operator performance must be evaluated before adoption and installation. Two experimental concepts for a Safety Parameters Display System (SPDS) were evaluated to assess benefits and potential problems associated with the SPDS concept and its integration into control room operations. Participants were licensed utility operators undergoing retraining on a nuclear power plant simulator. Both quantitative and qualitative data were collected and analyzed on crew response to seven simulated accident conditions

  13. Safety Evaluation for Packaging (onsite) T Plant Canyon Items

    Energy Technology Data Exchange (ETDEWEB)

    OBRIEN, J.H.

    2000-07-14

    This safety evaluation for packaging (SEP) evaluates and documents the ability to safely ship mostly unique inventories of miscellaneous T Plant canyon waste items (T-P Items) encountered during the canyon deck clean off campaign. In addition, this SEP addresses contaminated items and material that may be shipped in a strong tight package (STP). The shipments meet the criteria for onsite shipments as specified by Fluor Hanford in HNF-PRO-154, Responsibilities and Procedures for all Hazardous Material Shipments.

  14. Efficacy and safety of intravenous iron therapy as an alternative/adjunct to allogeneic blood transfusion.

    Science.gov (United States)

    Muñoz, M; Breymann, C; García-Erce, J A; Gómez-Ramírez, S; Comin, J; Bisbe, E

    2008-04-01

    Anaemia is a common condition among patients admitted to hospital medicosurgical departments, as well as in critically ill patients. Anaemia is more frequently due to absolute iron deficiency (e.g. chronic blood loss) or functional iron deficiency (e.g. chronic inflammatory states), with other causes being less frequent. In addition, preoperative anaemia is one of the major predictive factors for perioperative blood transfusion. In surgical patients, postoperative anaemia is mainly caused by perioperative blood loss, and it might be aggravated by inflammation-induced inhibition of erythropoietin and functional iron deficiency (a condition that cannot be corrected by the administration of oral iron). All these mechanisms may be involved in the anaemia of the critically ill. Intravenous iron administration seems to be safe, as very few severe side-effects were observed, and may result in hastened recovery from anaemia and lower transfusion requirements. However, it is noteworthy that many of the recommendations given for intravenous iron treatment are not supported by a high level of evidence and this must be borne in mind when making decisions regarding its application to a particular patient. Nonetheless, this also indicates the need for further large, randomized controlled trials on the safety and efficacy of intravenous iron for the treatment of anaemia in different clinical settings.

  15. International handbook of evaluated criticality safety benchmark experiments

    International Nuclear Information System (INIS)

    2010-01-01

    The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United States Department of Energy. The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) became an official activity of the Organization for Economic Cooperation and Development - Nuclear Energy Agency (OECD-NEA) in 1995. This handbook contains criticality safety benchmark specifications that have been derived from experiments performed at various nuclear critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculational techniques used to establish minimum subcritical margins for operations with fissile material and to determine criticality alarm requirement and placement. Many of the specifications are also useful for nuclear data testing. Example calculations are presented; however, these calculations do not constitute a validation of the codes or cross section data. The evaluated criticality safety benchmark data are given in nine volumes. These volumes span over 55,000 pages and contain 516 evaluations with benchmark specifications for 4,405 critical, near critical, or subcritical configurations, 24 criticality alarm placement / shielding configurations with multiple dose points for each, and 200 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications. Experiments that are found unacceptable for use as criticality safety benchmark experiments are discussed in these evaluations; however, benchmark specifications are not derived for such experiments (in some cases models are provided in an appendix). Approximately 770 experimental configurations are categorized as unacceptable for use as criticality safety benchmark experiments. Additional evaluations are in progress and will be

  16. RFID in the blood supply chain--increasing productivity, quality and patient safety.

    Science.gov (United States)

    Briggs, Lynne; Davis, Rodeina; Gutierrez, Alfonso; Kopetsky, Matthew; Young, Kassandra; Veeramani, Raj

    2009-01-01

    As part of an overall design of a new, standardized RFID-enabled blood transfusion medicine supply chain, an assessment was conducted for two hospitals: the University of Iowa Hospital and Clinics (UIHC) and Mississippi Baptist Health System (MBHS). The main objectives of the study were to assess RFID technological and economic feasibility, along with possible impacts to productivity, quality and patient safety. A step-by-step process analysis focused on the factors contributing to process "pain points" (errors, inefficiency, product losses). A process re-engineering exercise produced blueprints of RFID-enabled processes to alleviate or eliminate those pain-points. In addition, an innovative model quantifying the potential reduction in adverse patient effects as a result of RFID implementation was created, allowing improvement initiatives to focus on process areas with the greatest potential impact to patient safety. The study concluded that it is feasible to implement RFID-enabled processes, with tangible improvements to productivity and safety expected. Based on a comprehensive cost/benefit model, it is estimated for a large hospital (UIHC) to recover investment from implementation within two to three years, while smaller hospitals may need longer to realize ROI. More importantly, the study estimated that RFID technology could reduce morbidity and mortality effects substantially among patients receiving transfusions.

  17. Safety and cost evaluation of nuclear waste management

    International Nuclear Information System (INIS)

    Vieno, T.; Hautojaervi, A.; Korhonen, R.

    1989-11-01

    The report introduces the results of the nuclear waste management safety and cost evaluation research carried out in the Nuclear Engineering Laboratory of the Technical Research Centre of Finland (VTT) during the years 1984-1988. The emphasis is on the description of the state-of-art of performance and cost evaluation methods. The report describes VTT's most important assessment models. Development, verification and validation of the models has largely taken place within international projects, including the Stripa, HYDROCOIN, INTRACOIN, INTRAVAL, PSACOIN and BIOMOVS projects. Furthermore, VTT's other laboratories are participating in the Natural Analogue Working Group,k the CHEMVAL project and the CoCo group. Resent safety analyses carried out in the Nuclear Engineering Laboratory include a concept feasibility study of spent fuel disposal, safety analyses for the Preliminary Safety Analysis Reports (PSAR's) of the repositories to be constructed for low and medium level operational reactor waste at the Olkiluoto and Loviisa power plants as well as safety analyses of disposal of decommissioning wastes. Appendix 1 contains a comprehensive list of the most important publications and technical reports produced. They present the content and results of the research in detail

  18. Taipower's reload safety evaluation methodology for pressurized water reactors

    International Nuclear Information System (INIS)

    Huang, Ping-Hue; Yang, Y.S.

    1996-01-01

    For Westinghouse pressurized water reactors (PWRs) such as Taiwan Power Company's (TPC's) Maanshan Units 1 and 2, each of the safety analysis is performed with conservative reload related parameters such that reanalysis is not expected for all subsequent cycles. For each reload cycle design, it is required to perform a reload safety evaluation (RSE) to confirm the validity of the existing safety analysis for fuel cycle changes. The TPC's reload safety evaluation methodology for PWRs is based on 'Core Design and Safety Analysis Package' developed by the TPC and the Institute of Nuclear Energy Research (INER), and is an important portion of the 'Taipower's Reload Design and Transient Analysis Methodologies for Light Water Reactors'. The Core Management System (CMS) developed by Studsvik of America, the one-dimensional code AXINER developed by TPC, National Tsinghua University and INER, and a modified version of the well-known subchannel core thermal-hydraulic code COBRAIIIC are the major computer codes utilized. Each of the computer models is extensively validated by comparing with measured data and/or vendor's calculational results. Moreover, parallel calculations have been performed for two Maanshan reload cycles to validate the RSE methods. The TPC's in-house RSE tools have been applied to resolve many important plant operational issues and plant improvements, as well as to verify the vendor's fuel and core design data. (author)

  19. Home safe home: Evaluation of a childhood home safety program.

    Science.gov (United States)

    Stewart, Tanya Charyk; Clark, Andrew; Gilliland, Jason; Miller, Michael R; Edwards, Jane; Haidar, Tania; Batey, Brandon; Vogt, Kelly N; Parry, Neil G; Fraser, Douglas D; Merritt, Neil

    2016-09-01

    The London Health Sciences Centre Home Safety Program (HSP) provides safety devices, education, a safety video, and home safety checklist to all first-time parents for the reduction of childhood home injuries. The objective of this study was to evaluate the HSP for the prevention of home injuries in children up to 2 years of age. A program evaluation was performed with follow-up survey, along with an interrupted time series analysis of emergency department (ED) visits for home injuries 5 years before (2007-2013) and 2 years after (2013-2015) implementation. Spatial analysis of ED visits was undertaken to assess differences in home injury rates by dissemination areas controlling differences in socioeconomic status (i.e., income, education, and lone-parent status) at the neighborhood level. A total of 3,458 first-time parents participated in the HSP (a 74% compliance rate). Of these, 20% (n = 696) of parents responded to our questionnaire, with 94% reporting the program to be useful (median, 6; interquartile range, 2 on a 7-point Likert scale) and 81% learning new strategies for preventing home injuries. The median age of the respondent's babies were 12 months (interquartile range, 1). The home safety check list was used by 87% of respondents to identify hazards in their home, with 95% taking action to minimize the risk. The time series analysis demonstrated a significant decline in ED visits for home injuries in toddlers younger than2 years of age after HSP implementation. The declines in ED visits for home injuries remained significant over and above each socioeconomic status covariate. Removing hazards, supervision, and installing safety devices are key facilitators in the reduction of home injuries. Parents found the HSP useful to identify hazards, learn new strategies, build confidence, and provide safety products. Initial finding suggests that the program is effective in reducing home injuries in children up to 2 years of age. Therapeutic/care management study

  20. First investigations on the safety evaluation of smart sensors

    International Nuclear Information System (INIS)

    Bousquet, S.; Elsensohn, O.

    2001-10-01

    IPSN (Institute for Protection and Nuclear Safety) is the technical support for the French nuclear safety authority and thus involved in the safety evaluation of new I and C technologies and particularly of smart sensors. Smart sensors are characterized by the use of a microprocessor that converts the process variable into digital signals and exchanges other information with I and C control systems. There are two types of smart sensors: HART (Highway Addressable Remote Transducer) sensors, which provide both analogue (4 to 20 mA) and digital signals, and network sensors, which provide only digital signals. The expected benefits for operators are improved accuracy and reliability and cost savings in installation, commissioning, testing and maintenance. Safety evaluation of these smart sensors raises new issues: How does the sensor react to unknown commands? How to avoid unexpected changes in configuration? What is its sensitivity to electromagnetic interferences (EMI), to radiations...? In order to evaluate whether these sensors can be qualified for a safety application and to define the qualification tests to be done, IPSN has planned some functional and hardware tests (EMI, radiations) on 'HART' and field bus sensors. During the functional tests, we were not able to disrupt the HART tested sensors by invalid commands. However, these results cannot be extended to other sensors, because of the use of different technology, of different versions of hardware and software and of constructors' specific commands. Furthermore, easy modifications of configuration parameters can cause additional failures. Environmental tests are in progress on HART sensors and will be followed by experiments on field bus sensors. These preliminary investigations and the latest incident initiated by an incorrect computing algorithm of digital switchgear at Ringhals NPP, clearly illustrate that testing and verification programmes for smart equipment must be meticulously designed and reviewed

  1. First investigations on the safety evaluation of smart sensors

    Energy Technology Data Exchange (ETDEWEB)

    Bousquet, S.; Elsensohn, O. [CEA Fontenay aux Roses, 92 (France). Inst. de Protection et de Surete Nucleaire; Benoit, G. [CEA Saclay, Dir. de la Recherche Technologique DRT, 91 - Gif sur Yvette (France)

    2001-10-01

    IPSN (Institute for Protection and Nuclear Safety) is the technical support for the French nuclear safety authority and thus involved in the safety evaluation of new I and C technologies and particularly of smart sensors. Smart sensors are characterized by the use of a microprocessor that converts the process variable into digital signals and exchanges other information with I and C control systems. There are two types of smart sensors: HART (Highway Addressable Remote Transducer) sensors, which provide both analogue (4 to 20 mA) and digital signals, and network sensors, which provide only digital signals. The expected benefits for operators are improved accuracy and reliability and cost savings in installation, commissioning, testing and maintenance. Safety evaluation of these smart sensors raises new issues: How does the sensor react to unknown commands? How to avoid unexpected changes in configuration? What is its sensitivity to electromagnetic interferences (EMI), to radiations...? In order to evaluate whether these sensors can be qualified for a safety application and to define the qualification tests to be done, IPSN has planned some functional and hardware tests (EMI, radiations) on 'HART' and field bus sensors. During the functional tests, we were not able to disrupt the HART tested sensors by invalid commands. However, these results cannot be extended to other sensors, because of the use of different technology, of different versions of hardware and software and of constructors' specific commands. Furthermore, easy modifications of configuration parameters can cause additional failures. Environmental tests are in progress on HART sensors and will be followed by experiments on field bus sensors. These preliminary investigations and the latest incident initiated by an incorrect computing algorithm of digital switchgear at Ringhals NPP, clearly illustrate that testing and verification programmes for smart equipment must be meticulously designed

  2. [Evaluation of the quality control system in blood transfusion service].

    Science.gov (United States)

    Jovanović, R

    2000-01-01

    Implementation of quality system improvement at the Blood Transfusion Institute Novi Sad, included adjustments in practice to the request of ISO 9001 standard. Quality improvement must be a permanent activity of the Institute. The audit is a management tool for monitoring the quality assurance system and is either a quality audit or a medical audit. A well planned, comprehensive quality audit covers each activity of the Blood Transfusion Institute. The procedures may be internal or external. Quality manager is responsible for annual internal quality audits. The purpose of internal audits is to check the efficiency of the quality system in terms of realization of quality policy, fulfullment of designed targets and implementation of quality system documents. An internal quality audit is performed in accordance with the procedure and audit findings are reported to the management in a form of internal quality report as a part of quality system review. The findings must be communicated to all persons responsible for the controlled area. Quality manager can initiate an internal quality audit whenever it is realized that problems about the quality system have occurred. Audits are conducted by the quality manager or an audit team. The accurate list of internal auditors is kept in the Institute archive. Medical audit carried out by a transfusion committee, evaluates the quality of blood transfusion for determining the degree of compliance with established local or national guidelines, in order to promote optimal transfusion practice. Audits are not only used for determining further quality management activities, but also make basis for creating and maintenance of excellent relations with product and service users. Considering all this, Blood Transfusion Institute exceeds the requirements of ISO 9000 standards series.

  3. Safety evaluation status report for the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1989-07-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the earth-mounded concrete bunker (EMCB) alternative method of low-level radioactive waste disposal. The NRC reviewers relied extensively on the Standard Review Plan (SRP), Rev.1 (NUREG-1200), to evaluate the acceptability of the information provided in the EMCB PLASAR. The NRC staff selected certain review areas in the PLASAR for development of safety evaluation report input to provide examples of safety assessments that are necessary as part of a licensing review. Because of the fictitious nature of the assumed disposal site, and the decision to limit the review to essentially first-round review status, the NRC staff report is labeled a ''Safety Evaluation Status Report'' (SESR). Appendix A comprises the NRC review comments and questions on the information that DOE submitted in the PLASAR. The NRC concentrated its review on the design and operations-related portions of the EMCB PLASAR

  4. 29 CFR 1960.80 - Secretary's evaluations of agency occupational safety and health programs.

    Science.gov (United States)

    2010-07-01

    ... EMPLOYEE OCCUPATIONAL SAFETY AND HEALTH PROGRAMS AND RELATED MATTERS Evaluation of Federal Occupational Safety and Health Programs § 1960.80 Secretary's evaluations of agency occupational safety and health... evaluating an agency's occupational safety and health program. To accomplish this, the Secretary shall...

  5. Malaria and blood transfusion: major issues of blood safety in malaria-endemic countries and strategies for mitigating the risk of Plasmodium parasites.

    Science.gov (United States)

    Abdullah, Saleh; Karunamoorthi, Kaliyaperumal

    2016-01-01

    Malaria inflicts humankind over centuries, and it remains as a major threat to both clinical medicine and public health worldwide. Though hemotherapy is a life-sustaining modality, it continues to be a possible source of disease transmission. Hence, hemovigilance is a matter of grave concern in the malaria-prone third-world countries. In order to pursue an effective research on hemovigilance, a comprehensive search has been conducted by using the premier academic-scientific databases, WHO documents, and English-language search engines. One hundred two appropriate articles were chosen for data extraction, with a particular reference to emerging pathogens transmitted through blood transfusion, specifically malaria. Blood donation screening is done through microscopic examination and immunological assays to improve the safety of blood products by detection major blood-borne pathogens, viz., HIV, HBV, HCV, syphilis, and malarial parasites. Transfusion therapy significantly dwindles the preventable morbidity and mortality attributed to various illnesses and diseases, particularly AIDS, tuberculosis, and malaria. Examination of thick and thin blood smears are performed to detect positivity and to identify the Plasmodium species, respectively. However, all of these existing diagnostic tools have their own limitations in terms of sensitivity, specificity, cost-effectiveness, and lack of resources and skilled personnel. Globally, despite the mandate need of screening blood and its components according to the blood-establishment protocols, it is seldom practiced in the low-income/poverty-stricken settings. In addition, each and every single phase of transfusion chain carries sizable inherent risks from donors to recipients. Interestingly, opportunities also lie ahead to enhance the safety of blood-supply chain and patients. It can be achieved through sustainable blood-management strategies like (1) appropriate usage of precise diagnostic tools/techniques, (2) promoting

  6. Trial evaluations in comparison with the 1983 safety goals

    International Nuclear Information System (INIS)

    Riggs, R.; Sege, G.

    1985-06-01

    This report provides retrospective comparisons of selected generic regulatory actions to the 1983 NRC safety goals, which had been issued for evaluation during a two-year period. The issues covered are those analyzed by the Office of Nuclear Reactor Regulation (NRR) (assisted in some cases by the Battelle Pacific Northwest Laboratory). The issues include auxiliary feedwater reliability, pressurized thermal shock, power-operated relief valve isolation, asymmetric blowdown loads on PWR primary systems, pool dynamic loads for BWR containments, and steam generator tube rupture. Calculated core-melt frequencies, mortality risks, and cost-benefit ratios are compared with the corresponding safety-goal quantitative design objectives. Considerations that should influence interpretation of the comparisons are discussed. Comments are included on whether and how the safety goals may have helped in the regulatory decision process and on problems encountered

  7. Evaluating Models of Human Performance: Safety-Critical Systems Applications

    Science.gov (United States)

    Feary, Michael S.

    2012-01-01

    This presentation is part of panel discussion on Evaluating Models of Human Performance. The purpose of this panel is to discuss the increasing use of models in the world today and specifically focus on how to describe and evaluate models of human performance. My presentation will focus on discussions of generating distributions of performance, and the evaluation of different strategies for humans performing tasks with mixed initiative (Human-Automation) systems. I will also discuss issues with how to provide Human Performance modeling data to support decisions on acceptability and tradeoffs in the design of safety critical systems. I will conclude with challenges for the future.

  8. The discussion on the qualitative and quantitative evaluation methods for safety culture

    International Nuclear Information System (INIS)

    Gao Kefu

    2005-01-01

    The fundamental methods for safely culture evaluation are described. Combining with the practice of the quantitative evaluation of safety culture in Daya Bay NPP, the quantitative evaluation method for safety culture are discussed. (author)

  9. Novel modular natural circulation BWR design and safety evaluation

    International Nuclear Information System (INIS)

    Ishii, Mamoru; Shi, Shanbin; Yang, Won Sik; Wu, Zeyun; Rassame, Somboon; Liu, Yang

    2015-01-01

    Highlights: • Introduction of BWR-type natural circulation small modular reactor preliminary design (NMR-50). • Design of long fuel cycle length for the NMR-50. • Design of double passive safety systems for the NMR-50. • RELAP5 analyses of design basis accidents for the NMR-50. - Abstract: The Purdue NMR (Novel Modular Reactor) represents a BWR-type small modular reactor with a significantly reduced reactor pressure vessel (RPV) height. Specifically, it has one third the height of a conventional BWR RPV with an electrical output of 50 MWe. The preliminary design of the NMR-50 including reactor, fuel cycle, and safety systems is described and discussed. The improved neutronics design of the NMR-50 extends the fuel cycle length up to 10 years. The NMR-50 is designed with double passive engineering safety system, which is intended to withstand a prolonged station black out with loss of ultimate heat sink accident such as experienced at Fukushima. In order to evaluate the safety features of the NMR-50, two representative design basis accidents, i.e. main steam line break (MSLB) and bottom drain line break (BDLB), are simulated by using the best-estimate thermal–hydraulic code RELAP5. The RPV water inventory, containment pressure, and the performance of engineering safety systems are investigated for about 33 h after the initiation of the accidents

  10. Safety evaluation of zotepine for the treatment of schizophrenia.

    Science.gov (United States)

    Riedel, Michael; Musil, Richard; Seemüller, Florian; Spellmann, Ilja; Möller, Hans-Jürgen; Schennach-Wolff, Rebecca

    2010-07-01

    Atypical antipsychotics have become the first-line treatment for patients suffering from schizophrenia in the industrialized world. Given the frequent necessity of a life-long enduring antipsychotic treatment, the compounds' safety profile is of great importance for patients and caregivers. Zotepine is an antipsychotic with atypical properties and previous data have suggested a very favorable side effect profile. The aim of this review is to provide a broad knowledge base on the safety profile of zotepine deriving from currently available research results published in English medical databases. The focus of this research reports starts in the 1990s with zotepine's approval in Europe. This paper incorporates data on placebo-controlled studies of zotepine as well as studies with comparator compounds also beyond the diagnostic boarder of schizophrenia regarding zotepine's safety. The take home message of this safety evaluation of zotepine is that compared to typical compounds zotepine induces less extrapyramidal side effects; however, in terms of comparing zotepine's safety with other atypical antipsychotics more studies are needed to draw final conclusions.

  11. Road network safety evaluation using Bayesian hierarchical joint model.

    Science.gov (United States)

    Wang, Jie; Huang, Helai

    2016-05-01

    Safety and efficiency are commonly regarded as two significant performance indicators of transportation systems. In practice, road network planning has focused on road capacity and transport efficiency whereas the safety level of a road network has received little attention in the planning stage. This study develops a Bayesian hierarchical joint model for road network safety evaluation to help planners take traffic safety into account when planning a road network. The proposed model establishes relationships between road network risk and micro-level variables related to road entities and traffic volume, as well as socioeconomic, trip generation and network density variables at macro level which are generally used for long term transportation plans. In addition, network spatial correlation between intersections and their connected road segments is also considered in the model. A road network is elaborately selected in order to compare the proposed hierarchical joint model with a previous joint model and a negative binomial model. According to the results of the model comparison, the hierarchical joint model outperforms the joint model and negative binomial model in terms of the goodness-of-fit and predictive performance, which indicates the reasonableness of considering the hierarchical data structure in crash prediction and analysis. Moreover, both random effects at the TAZ level and the spatial correlation between intersections and their adjacent segments are found to be significant, supporting the employment of the hierarchical joint model as an alternative in road-network-level safety modeling as well. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. Evaluation Of Blood Component Request And Ultrasound In ...

    African Journals Online (AJOL)

    Results: A total of 1097 blood component was requested for transfusion. Out of these, 1066 were used and 31 were returned and later discarded due to contamination. The commonest prescribed blood type was whole blood (81.1%) Blood used was higher for obstetrics and gynaecological cases and least for paediatric ...

  13. Evaluating the effectiveness of active vehicle safety systems.

    Science.gov (United States)

    Jeong, Eunbi; Oh, Cheol

    2017-03-01

    Advanced vehicle safety systems have been widely introduced in transportation systems and are expected to enhance traffic safety. However, these technologies mainly focus on assisting individual vehicles that are equipped with them, and less effort has been made to identify the effect of vehicular technologies on the traffic stream. This study proposed a methodology to assess the effectiveness of active vehicle safety systems (AVSSs), which represent a promising technology to prevent traffic crashes and mitigate injury severity. The proposed AVSS consists of longitudinal and lateral vehicle control systems, which corresponds to the Level 2 vehicle automation presented by the National Highway Safety Administration (NHTSA). The effectiveness evaluation for the proposed technology was conducted in terms of crash potential reduction and congestion mitigation. A microscopic traffic simulator, VISSIM, was used to simulate freeway traffic stream and collect vehicle-maneuvering data. In addition, an external application program interface, VISSIM's COM-interface, was used to implement the AVSS. A surrogate safety assessment model (SSAM) was used to derive indirect safety measures to evaluate the effectiveness of the AVSS. A 16.7-km freeway stretch between the Nakdong and Seonsan interchanges on Korean freeway 45 was selected for the simulation experiments to evaluate the effectiveness of AVSS. A total of five simulation runs for each evaluation scenario were conducted. For the non-incident conditions, the rear-end and lane-change conflicts were reduced by 78.8% and 17.3%, respectively, under the level of service (LOS) D traffic conditions. In addition, the average delay was reduced by 55.5%. However, the system's effectiveness was weakened in the LOS A-C categories. Under incident traffic conditions, the number of rear-end conflicts was reduced by approximately 9.7%. Vehicle delays were reduced by approximately 43.9% with 100% of market penetration rate (MPR). These results

  14. Packaging Evaluation Approach to Improve Cosmetic Product Safety

    Directory of Open Access Journals (Sweden)

    Benedetta Briasco

    2016-09-01

    Full Text Available In the Regulation 1223/2009, evaluation of packaging has become mandatory to assure cosmetic product safety. In fact, the safety assessment of a cosmetic product can be successfully carried out only if the hazard deriving from the use of the designed packaging for the specific product is correctly evaluated. Despite the law requirement, there is too little information about the chemical-physical characteristics of finished packaging and the possible interactions between formulation and packaging; furthermore, different from food packaging, the cosmetic packaging is not regulated and, to date, appropriate guidelines are still missing. The aim of this work was to propose a practical approach to investigate commercial polymeric containers used in cosmetic field, especially through mechanical properties’ evaluation, from a safety point of view. First of all, it is essential to obtain complete information about raw materials. Subsequently, using an appropriate full factorial experimental design, it is possible to investigate the variables, like polymeric density, treatment, or type of formulation involved in changes to packaging properties or in formulation-packaging interaction. The variation of these properties can greatly affect cosmetic safety. In particular, mechanical properties can be used as an indicator of pack performances and safety. As an example, containers made of two types of polyethylene with different density, low-density polyethylene (LDPE and high-density polyethylene (HDPE, are investigated. Regarding the substances potentially extractable from the packaging, in this work the headspace solid-phase microextraction method (HSSPME was used because this technique was reported in the literature as suitable to detect extractables from the polymeric material here employed.

  15. Human immunodeficiency virus prevalence, incidence, and residual transmission risk in first-time and repeat blood donations in Zimbabwe : implications on blood safety

    NARCIS (Netherlands)

    Mapako, Tonderai; Mvere, David A.; Chitiyo, McLeod E.; Rusakaniko, Simbarashe; Postma, Maarten J.; Van Hulst, Marinus

    2013-01-01

    BACKGROUND: National Blood Service Zimbabwe human immunodeficiency virus (HIV) risk management strategy includes screening and discarding of first-time donations, which are collected in blood packs without an anticoagulant (dry pack). To evaluate the impact of discarding first-time donations on

  16. Fuel Receiving and Storage Station. Nuclear Regulatory Commission's safety evaluation report

    International Nuclear Information System (INIS)

    1976-01-01

    The safety evaluation report covers design of structures, components, equipment, and systems; nuclear criticality safety; radiological safety; accident analysis; conduct of operations; quality assurance; common defense and security; financial qualifications; financial protection and indemnity requirements; and technical specifications

  17. Occurrence of lead-related symptoms below the current occupational safety and health act allowable blood lead levels.

    Science.gov (United States)

    Rosenman, Kenneth D; Sims, Amy; Luo, Zhehui; Gardiner, Joseph

    2003-05-01

    To determine the occurrence of symptoms of lead toxicity at levels below the current allowable Occupational Safety and Health Act blood lead level of 50 micrograms/dL, standardized telephone interviews were conducted of individuals reported to a statewide laboratory-based surveillance system. Four hundred and ninety-seven, or 75%, of the eligible participants were interviewed. Gastrointestinal, musculoskeletal, and nervous system symptoms increased with increasing blood lead levels. Nervous, gastrointestinal, and musculoskeletal symptoms all began to be increased in individuals with blood leads between 30-39 micrograms/dL and possibly at levels as low as 25-30 micrograms/dL for nervous system symptoms. The results of this study of increased symptoms are consistent with and provide added weight to previous results showing subclinical changes in the neurologic and renal systems and sperm counts at blood lead levels currently allowed by the Occupational Safety and Health Act.

  18. A progressive methodology for seismic safety evaluation of gravity dams

    International Nuclear Information System (INIS)

    Ghrib, F.; Leger, P.; Tinawi, R.; Lupien, R.; Veilleux, M.

    1995-01-01

    A progressive methodology for the seismic safety evaluation of existing concrete gravity dams was described. The methodology was based on five structural analysis levels with increasing complexity to represent inertia forces, dam-foundation and dam-interaction mechanisms, as well as concrete cracking. The five levels were (1) preliminary screening, (2) pseudo-static method, (3) pseudo-dynamic method, (4) linear time history analysis, and (5) non-linear history analysis. The first four levels of analysis were applied for the seismic safety evaluation of Paugan gravity dam (Quebec). Results showed that internal forces from pseudo-dynamic, response spectra and transient finite element analyses could be used to interpret the dynamic stability of dams from familiar strength-based criteria. However, as soon as the base was cracked, the seismically induced forces were modified, and level IV analyses proved more suitable to handle rationally these complexities. 8 refs., 7 figs., 1 tab

  19. On Some Methods in Safety Evaluation in Geotechnics

    Directory of Open Access Journals (Sweden)

    Puła Wojciech

    2015-06-01

    Full Text Available The paper demonstrates how the reliability methods can be utilised in order to evaluate safety in geotechnics. Special attention is paid to the so-called reliability based design that can play a useful and complementary role to Eurocode 7. In the first part, a brief review of first- and second-order reliability methods is given. Next, two examples of reliability-based design are demonstrated. The first one is focussed on bearing capacity calculation and is dedicated to comparison with EC7 requirements. The second one analyses a rigid pile subjected to lateral load and is oriented towards working stress design method. In the second part, applications of random field to safety evaluations in geotechnics are addressed. After a short review of the theory a Random Finite Element algorithm to reliability based design of shallow strip foundation is given. Finally, two illustrative examples for cohesive and cohesionless soils are demonstrated.

  20. On Some Methods in Safety Evaluation in Geotechnics

    Science.gov (United States)

    Puła, Wojciech; Zaskórski, Łukasz

    2015-06-01

    The paper demonstrates how the reliability methods can be utilised in order to evaluate safety in geotechnics. Special attention is paid to the so-called reliability based design that can play a useful and complementary role to Eurocode 7. In the first part, a brief review of first- and second-order reliability methods is given. Next, two examples of reliability-based design are demonstrated. The first one is focussed on bearing capacity calculation and is dedicated to comparison with EC7 requirements. The second one analyses a rigid pile subjected to lateral load and is oriented towards working stress design method. In the second part, applications of random field to safety evaluations in geotechnics are addressed. After a short review of the theory a Random Finite Element algorithm to reliability based design of shallow strip foundation is given. Finally, two illustrative examples for cohesive and cohesionless soils are demonstrated.

  1. Safety evaluation for packaging (onsite) product removal can containers

    International Nuclear Information System (INIS)

    Burnside, M.E.

    1998-01-01

    Six Product Removal (PR) Cans and Containers are located within the Plutonium Finishing Plant. Each can is expected to contain a maximum of 3 g of residual radioactive material, consisting mainly of plutonium isotopes. The PR Can Containers were previously authorized by HNF-SD-TP-SEP-064, Rev. 0 (Boettger 1997), for the interarea transport of up to 3 g of plutonium. The purpose of this safety evaluation for packaging is to allow the transport of six PR Cans with their Containers from the Plutonium Finishing Plant to the 233 S Evaporator Facility. This safety evaluation for packaging is authorized for use until April 29, 1999, or until the shipment is made, whichever happens first

  2. Radiological safety evaluation report for NUWAX-79 exercise

    International Nuclear Information System (INIS)

    King, W.C.

    1979-03-01

    An analysis of the radiological safety of the NUWAX-79 exercise to be conducted on the Nevada Test Site in April 1979 is given. An evaluation of the radiological safety to the participants is made using depleted uranium (D-38) in mock weapons parts, and 223 Ra and its daughters as a radioactive contaminant of equipment and terrain. The radiological impact to offsite persons is also discussed, particularly for people living at Lathrop Wells, Nevada, which is located 7 miles south of the site proposed for the exercise. It is the conclusion of this evaluation that the potential radiological risk of this exercise is very low, and that no individual should receive exposure to radioactivity greater than one-tenth of the level permitted under current federal radiation exposure guidelines

  3. Evaluation of the food safety training for food handlers in restaurant operations

    OpenAIRE

    Park, Sung-Hee; Kwak, Tong-Kyung; Chang, Hye-Ja

    2010-01-01

    This study examined the extent of improvement of food safety knowledge and practices of employee through food safety training. Employee knowledge and practice for food safety were evaluated before and after the food safety training program. The training program and questionnaires for evaluating employee knowledge and practices concerning food safety, and a checklist for determining food safety performance of restaurants were developed. Data were analyzed using the SPSS program. Twelve restaur...

  4. Safety and feasibility of countering neurological impairment by intravenous administration of autologous cord blood in cerebral palsy

    Directory of Open Access Journals (Sweden)

    Lee Young-Ho

    2012-03-01

    Full Text Available Abstract Backgrounds We conducted a pilot study of the infusion of intravenous autologous cord blood (CB in children with cerebral palsy (CP to assess the safety and feasibility of the procedure as well as its potential efficacy in countering neurological impairment. Methods Patients diagnosed with CP were enrolled in this study if their parents had elected to bank their CB at birth. Cryopreserved CB units were thawed and infused intravenously over 10~20 minutes. We assessed potential efficacy over 6 months by brain magnetic resonance imaging (MRI-diffusion tensor imaging (DTI, brain perfusion single-photon emission computed tomography (SPECT, and various evaluation tools for motor and cognitive functions. Results Twenty patients received autologous CB infusion and were evaluated. The types of CP were as follows: 11 quadriplegics, 6 hemiplegics, and 3 diplegics. Infusion was generally well-tolerated, although 5 patients experienced temporary nausea, hemoglobinuria, or urticaria during intravenous infusion. Diverse neurological domains improved in 5 patients (25% as assessed with developmental evaluation tools as well as by fractional anisotropy values in brain MRI-DTI. The neurologic improvement occurred significantly in patients with diplegia or hemiplegia rather than quadriplegia. Conclusions Autologous CB infusion is safe and feasible, and has yielded potential benefits in children with CP.

  5. Clinical evaluation of a 51Cr-labeled red blood cell survival test for in vivo blood compatibility testing

    International Nuclear Information System (INIS)

    Pineda, A.A.; Dharkar, D.D.; Wahner, H.W.

    1984-01-01

    Modified red blood cell survival studies with use of 51Cr were performed in three groups of subjects. Group 1 consisted of normal subjects who were given labeled autologous blood, group 2 were subjects in need of blood transfusions and given labeled ABO and Rh crossmatch-compatible blood, and group 3 were patients in need of blood transfusion but in whom problems arose in finding compatible blood. The results of the studies suggest that for patients with blood compatibility problems, normal red blood cell survival values at 1 hour do not exclude the possibility of severe hemolysis 24 hours later. Thus, if a 1-hour test result is normal, the procedure should be extended routinely to 24 hours. Moreover, the test can be used to evaluate the clinical importance of antibodies. We showed that anti-Yka and anti-Lan were clinically significant, but high-titer, low-avidity antibodies, anti-Kna, anti-I, and anti-HI were clinically insignificant in the cases studied. This finding emphasizes the importance of an in vivo test for the final compatibility evaluation in complicated blood replacement problems

  6. Problem of evaluating the safety of an explosive

    International Nuclear Information System (INIS)

    Smith, L.C.

    1977-01-01

    Some general considerations on the problem of evaluating the safety of an explosive lead to the reasons why the much-criticized drop-weight impact machine remains an important tool in most explosive research and development laboratories. Problems related to the design, calibration, and use of such machines, and certain misconceptions concerning the interpretation of the test data, are discussed. The results of an unsuccessful attempt to construct a more comprehensive hazards scale also are described

  7. Does external evaluation of laboratories improve patient safety?

    Science.gov (United States)

    Noble, Michael A

    2007-01-01

    Laboratory accreditation and External Quality Assessment (also called proficiency testing) are mainstays of laboratory quality assessment and performance. Both practices are associated with examples of improved laboratory performance. The relationship between laboratory performance and improved patient safety is more difficult to assess because of the many variables that are involved with patient outcome. Despite this difficulty, the argument to continue external evaluation of laboratories is too compelling to consider the alternative.

  8. Technical evaluation of seismic qualification of safety-related equipment

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yang Hui; Park, Heong Gee; Park, Yeong Seok [Univ. of Incheon, Incheon (Korea, Republic of)

    1994-04-15

    This study is purposed to evaluate the technical acceptability of the procedures and techniques of seismic qualifications which were performed for the YGN 3 and 4 safety-related equipment.This study is also targeted to suggest a systematized technical procedure guide for the effective performance and review of the seismic qualification, which reflects the most up-to-date licensing requirements and state-of the-art.

  9. Safety evaluation for packaging (onsite) depleted uranium waste boxes

    Energy Technology Data Exchange (ETDEWEB)

    McCormick, W.A.

    1997-08-27

    This safety evaluation for packaging (SEP) allows the one-time shipment of ten metal boxes and one wooden box containing depleted uranium material from the Fast Flux Test Facility to the burial grounds in the 200 West Area for disposal. This SEP provides the analyses and operational controls necessary to demonstrate that the shipment will be safe for the onsite worker and the public.

  10. Bringing structure into road safety evaluation: a hierarchy of indicators

    OpenAIRE

    HERMANS, Elke; BRIJS, Tom; WETS, Geert; SHEN, Yongjun

    2010-01-01

    In recent years, there has been an explosion of interest in indicators in several domains. This reflects growing recognition of the important role indicators can play as a tool for enhancing the quality of decision making. Indicators express an aspect of a phenomenon in an understandable and relevant way and are useful in terms of monitoring, evaluation and communication. Like other policies, road safety policy could benefit from the use of indicators able to measure changes and progress towa...

  11. Bringing structure into road safety evaluation: a hierarchy of indicators

    OpenAIRE

    HERMANS, Elke; BRIJS, Tom; WETS, Geert

    2010-01-01

    In recent years, there has been an explosion of interest in indicators in several domains. This reflects growing recognition of the important role indicators can play as a tool for enhancing the quality of decision making. Indicators express an aspect of a phenomenom in an understandable and relevant way and are useful in terms of monitoring, evaluation and communication. Like other policies, road safety policy could benefit from the use of indicators able to measure changes and progress towa...

  12. Safety evaluation for packaging (onsite) depleted uranium waste boxes

    International Nuclear Information System (INIS)

    McCormick, W.A.

    1997-01-01

    This safety evaluation for packaging (SEP) allows the one-time shipment of ten metal boxes and one wooden box containing depleted uranium material from the Fast Flux Test Facility to the burial grounds in the 200 West Area for disposal. This SEP provides the analyses and operational controls necessary to demonstrate that the shipment will be safe for the onsite worker and the public

  13. Pathogen reduction and blood transfusion safety in Africa: strengths, limitations and challenges of implementation in low-resource settings.

    Science.gov (United States)

    Ware, A D; Jacquot, C; Tobian, A A R; Gehrie, E A; Ness, P M; Bloch, E M

    2018-01-01

    Transfusion-transmitted infection risk remains an enduring challenge to blood safety in Africa. A high background incidence and prevalence of the major transfusion-transmitted infections (TTIs), dependence on high-risk donors to meet demand, suboptimal testing and quality assurance collectively contribute to the increased risk. With few exceptions, donor testing is confined to serological evaluation of human immunodeficiency virus (HIV), hepatitis B and C (HBV and HCV) and syphilis. Barriers to implementation of broader molecular methods include cost, limited infrastructure and lack of technical expertise. Pathogen reduction (PR), a term used to describe a variety of methods (e.g. solvent detergent treatment or photochemical activation) that may be applied to blood following collection, offers the means to diminish the infectious potential of multiple pathogens simultaneously. This is effective against different classes of pathogen, including the major TTIs where laboratory screening is already implemented (e.g. HIV, HBV and HCV) as well pathogens that are widely endemic yet remain unaddressed (e.g. malaria, bacterial contamination). We sought to review the available and emerging PR techniques and their potential application to resource-constrained parts of Africa, focusing on the advantages and disadvantages of such technologies. PR has been slow to be adopted even in high-income countries, primarily given the high costs of use. Logistical considerations, particularly in low-resourced parts of Africa, also raise concerns about practicality. Nonetheless, PR offers a rational, innovative strategy to contend with TTIs; technologies in development may well present a viable complement or even alternative to targeted screening in the future. © 2017 International Society of Blood Transfusion.

  14. A colourimetric evaluation of the effect of bacterial contamination on teeth stained with blood in vitro: Evaluation of the efficacy of two different bleaching regimes.

    Science.gov (United States)

    Wang, S; Cathro, P; Heithersay, G; Briggs, N; Ratnayake, J; Zilm, P

    2018-02-27

    Tooth discolouration could occur due to bacterial contamination in traumatized teeth. Hydrogen peroxide is the commonly used bleaching agent. However, due to concerns over safety, alternative bleaching regimes such as sodium perborate (S) and thiourea-hydrogen peroxide (T) have been investigated. Apices resected and pulp extirpated 99 premolars were divided into two groups. Group 1 and 2 was injected with blood and blood/bacteria, stored anaerobically for 35 days. The two groups were treated by bleaching with water, S or T. Teeth were rebleached after 7 days. Colourimetric evaluation was assessed using digital imaging, CasMatch standardization and CIE L*a*b colour system preoperatively, 35 days of staining and 7 and 14 of bleaching. A linear mixed model with fixed effects of time, group and bleach was used to examine colour difference. Blood-stained teeth were significantly redder and darker on day 35 compared with blood/bacteria-stained teeth. After bleaching, blood-stained teeth retained significant redness compared with blood/bacteria-stained teeth using either S or T. T produced a significantly whiter shade in both the groups after 14 days. Blood-stained teeth were significantly darker and red compared with blood/bacteria-stained teeth. T bleaching regime was more effective than S. © 2018 Australian Dental Association.

  15. Therapeutic efficacy and safety evaluation of erythrocyte concentrate used in dogs

    Directory of Open Access Journals (Sweden)

    Ildiko Barabasi

    2016-11-01

    Full Text Available Therapeutic efficacy and safety evaluation of erythrocyte concentrate used in dogs 1Ildikó BARABÁSI, 1Cristina ȘTEFǍNUȚ, 1Laurenţ OGNEAN 1University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400037, Manastur street, no.3-5, Cluj-Napoca, Romania *Corresponding author: lognean@yahoo.com   Keywords: dogs, erythrocyte concentrate, hematocrit, immune-mediated hemolytic anemia, transfusion therapy Introduction: The minimum dose of whole blood products as well as erythrocyte concentrate has been under a lot of debate, new equations for calculating the optimal dose being made up from a large variety of hematologists (Kisielewicz et al 2014; Helm and Knottenbelt, 2010; Gibson, 2007. Aim: The therapeutical efficacy of erythrocyte concentrates in dogs with different types of anemia by measuring the hematocrit level 6 hours after the transfusion and a complete blood count 5 days post-transfusion therapy. Materials and methods: Blood tests were performed with ADIVA hematological analyzer; the 6 hour post-transfusion hematocrit was determined by a micro hematocrit. On admission every patient received a routine blood test that included 40 hematological parameters and 21 biochemical parameters. In addition, a detailed examination of the blood smears was also performed by the ADIVA hematological analyzer with 26 parameters that mostly referred to red blood cell and white blood cell morphology. Blood typing was done using the RapidVet quick test kit. Patients received only type specific blood and to limit transfusion reaction occurrences, in addition, a crossmatch test was performed before every transfusion. Statistical analysis was accomplished with GraphPadInStat 3.0 and the graphical depiction of the obtained results was made using the Origin 8.5. graphics program. Results: Statistical analysis reveal that the total red blood cell count underwent very significant changes (p=0.0052 as well as the hemoglobin (p=0.0085. The hematocrit

  16. Development of a Novel Nuclear Safety Culture Evaluation Method for an Operating Team Using Probabilistic Safety Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sangmin; Lee, Seung Min; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of)

    2015-05-15

    IAEA defined safety culture as follows: 'Safety Culture is that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance'. Also, celebrated behavioral scientist, Cooper, defined safety culture as,'safety culture is that observable degree of effort by which all organizational members direct their attention and actions toward improving safety on a daily basis' with his internal psychological, situational, and behavioral context model. With these various definitions and criteria of safety culture, several safety culture assessment methods have been developed to improve and manage safety culture. To develop a new quantitative safety culture evaluation method for an operating team, we unified and redefined safety culture assessment items. Then we modeled a new safety culture evaluation by adopting level 1 PSA concept. Finally, we suggested the criteria to obtain nominal success probabilities of assessment items by using 'operational definition'. To validate the suggested evaluation method, we analyzed the collected audio-visual recording data collected from a full scope main control room simulator of a NPP in Korea.

  17. Development of a Novel Nuclear Safety Culture Evaluation Method for an Operating Team Using Probabilistic Safety Analysis

    International Nuclear Information System (INIS)

    Han, Sangmin; Lee, Seung Min; Seong, Poong Hyun

    2015-01-01

    IAEA defined safety culture as follows: 'Safety Culture is that assembly of characteristics and attitudes in organizations and individuals which establishes that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance'. Also, celebrated behavioral scientist, Cooper, defined safety culture as,'safety culture is that observable degree of effort by which all organizational members direct their attention and actions toward improving safety on a daily basis' with his internal psychological, situational, and behavioral context model. With these various definitions and criteria of safety culture, several safety culture assessment methods have been developed to improve and manage safety culture. To develop a new quantitative safety culture evaluation method for an operating team, we unified and redefined safety culture assessment items. Then we modeled a new safety culture evaluation by adopting level 1 PSA concept. Finally, we suggested the criteria to obtain nominal success probabilities of assessment items by using 'operational definition'. To validate the suggested evaluation method, we analyzed the collected audio-visual recording data collected from a full scope main control room simulator of a NPP in Korea

  18. Evaluation of safety parameter display concepts. Final report

    International Nuclear Information System (INIS)

    Woods, D.D.; Wise, J.A.; Hanes, L.F.

    1982-02-01

    New control room equipment designed to improve operator performance must be evaluated before adoption and installation. Two experimental concept for a Safety Parameters Display System (SPDS) were evaluated to assess benefits and potential problems associated with the SPDS concept and its integration into control room operations. Participants were licensed utility operators undergoing retraining on a nuclear power plant simulator. Both quantitative and qualitative data were collected and analyzed on crew response to seven simulated accident conditions. Data on operator decisions and actions have been organized into timelines. Analysis of the timelines and observations collected during testing provide important insights about the potential impact of the SPDS concept on control room operations

  19. Evaluation of the Community's nuclear reactor safety research programme

    International Nuclear Information System (INIS)

    Brandstetter, A.; Goedkoop, J.A.; Jaumotte, A.; Malhouitre, G.; Tomkins, B.; Zorzoli, G.B.

    1986-01-01

    This report describes an evaluation of the 1980-85 CEC reactor safety programme prepared, at the invitation of the Commission, by a panel of six independent experts by means of examining the relevant document and by holding hearings with the responsible CEC staff. It contains the recommendations made by the panel on the following topics: the need for the JRC to continue to make its competence in the reactor safety field available to the Community; the importance of continuity in the JRC and shared-cost action programmes; the difficulty of developing reactor safety research programmes which satisfy the needs of users with diverse needs; the monitoring of the utilization of the research results; the maintenance of the JRC computer codes used by the Member States; the spin-off from research results being made available to other industrial sectors; the continued contact between the JRC researchers and the national experts; the coordination of LWR safety research with that of the Member States; and, the JRC work on fast breeders to be planned with regard to the R and D programmes of the Fast Reactor European Consortium

  20. Safety Evaluation of Kartini Reactor Based on Instrumentation System Design

    International Nuclear Information System (INIS)

    Tjipta Suhaemi; Djen Djen Dj; Itjeu K; Johnny S; Setyono

    2003-01-01

    The safety of Kartini reactor has been evaluated based on instrumentation system aspect. The Kartini reactor is designed by BATAN. Design power of the reactor is 250 kW, but it is currently operated at 100 kW. Instrumentation and control system function is to monitor and control the reactor operation. Instrumentation and control system consists of safety system, start-up and automatic power control, and process information system. The linear power channel and logarithmic power channel are used for measuring power. There are 3 types of control rod for controlling the power, i.e. safety rod, shim rod, and regulating rod. The trip and interlock system are used for safety. There are instrumentation equipment used for measuring radiation exposure, flow rate, temperature and conductivity of fluid The system of Kartini reactor has been developed by introducing a process information system, start-up system, and automatic power control. It is concluded that the instrumentation of Kartini reactor has followed the requirement and standard of IAEA. (author)

  1. Safety evaluation of BWR off-gas treatment systems

    International Nuclear Information System (INIS)

    Schultz, R.J.; Schmitt, R.C.

    1975-01-01

    Some of the results of a safety evaluation performed on current generic types of BWR off-gas treatment systems including cooled and ambient temperature adsorber beds and cryogenics are presented. The evaluation covered the four generic types of off-gas systems and the systems of five major vendors. This study was part of original work performed under AEC contract for the Directorate of Regulatory Standards. The analysis techniques employed for the safety evaluation of these systems include: Fault Tree Analysis; FMECA (Failure Mode Effects and Criticality Analysis); general system comparisons, contaminant, system control, and design adequacy evaluations; and resultant Off-Site Dose Calculations. The salient areas presented are some of the potential problem areas, the approach that industry has taken to mitigate or design against potential upset conditions, and areas where possible deficiencies still exist. Potential problem areas discussed include hydrogen detonation, hydrogen release to equipment areas, operator/automatic control interface, and needed engineering evaluation to insure safe system operation. Of the systems reviewed, most were in the category of advanced or improved over that commonly in use today, and a conclusion from the study was that these systems offer excellent potential for noble gas control for BWR power plants where more stringent controls may be specified -- now or in the future. (U.S.)

  2. Electronic clinical safety reporting system: a benefits evaluation.

    Science.gov (United States)

    Elliott, Pamela; Martin, Desmond; Neville, Doreen

    2014-06-11

    Eastern Health, a large health care organization in Newfoundland and Labrador (NL), started a staged implementation of an electronic occurrence reporting system (used interchangeably with "clinical safety reporting system") in 2008, completing Phase One in 2009. The electronic clinical safety reporting system (CSRS) was designed to replace a paper-based system. The CSRS involves reporting on occurrences such as falls, safety/security issues, medication errors, treatment and procedural mishaps, medical equipment malfunctions, and close calls. The electronic system was purchased from a vendor in the United Kingdom that had implemented the system in the United Kingdom and other places, such as British Columbia. The main objective of the new system was to improve the reporting process with the goal of improving clinical safety. The project was funded jointly by Eastern Health and Canada Health Infoway. The objectives of the evaluation were to: (1) assess the CSRS on achieving its stated objectives (particularly, the benefits realized and lessons learned), and (2) identify contributions, if any, that can be made to the emerging field of electronic clinical safety reporting. The evaluation involved mixed methods, including extensive stakeholder participation, pre/post comparative study design, and triangulation of data where possible. The data were collected from several sources, such as project documentation, occurrence reporting records, stakeholder workshops, surveys, focus groups, and key informant interviews. The findings provided evidence that frontline staff and managers support the CSRS, identifying both benefits and areas for improvement. Many benefits were realized, such as increases in the number of occurrences reported, in occurrences reported within 48 hours, in occurrences reported by staff other than registered nurses, in close calls reported, and improved timelines for notification. There was also user satisfaction with the tool regarding ease of use

  3. Prehospital point of care testing of blood gases and electrolytes — an evaluation of IRMA

    OpenAIRE

    Prause, Gerhard; Ratzenhofer-Komenda, Beatrice; Offner, Anton; Lauda, Peter; Voit, Henrika; Pojer, Horst

    1997-01-01

    Background: This study evaluated the feasibility of blood gas analysis and electrolyte measurements during emergency transport prior to hospital admission. Results: A portable, battery-powered blood analyzer was used on patients in life threatening conditions to determine pH, pCO2, pO2, sodium, potassium and ionized calcium. Arterial blood was used for blood gas analysis and electrolyte measurements. Venous blood was used for electrolyte measurement alone. During the observation period of 4 m...

  4. Evaluation of criteria for developing traffic safety materials for Latinos.

    Science.gov (United States)

    Streit-Kaplan, Erica L; Miara, Christine; Formica, Scott W; Gallagher, Susan Scavo

    2011-03-01

    This quantitative study assessed the validity of guidelines that identified four key characteristics of culturally appropriate Spanish-language traffic safety materials: language, translation, formative evaluation, and credible source material. From a sample of 190, the authors randomly selected 12 Spanish-language educational materials for analysis by 15 experts. Hypotheses included that the experts would rate materials with more of the key characteristics as more effective (likely to affect behavioral change) and rate materials originally developed in Spanish and those that utilized formative evaluation (e.g., pilot tests, focus groups) as more culturally appropriate. Although results revealed a weak association between the number of key characteristics in a material and the rating of its effectiveness, reviewers rated materials originally created in Spanish and those utilizing formative evaluation as significantly more culturally appropriate. The findings and methodology demonstrated important implications for developers and evaluators of any health-related materials for Spanish speakers and other population groups.

  5. Evaluation of CF/CM, concentration ratios for elements in fetus to mother, using cord blood and maternal blood

    International Nuclear Information System (INIS)

    Watanabe, Y.; Yukawa, M.; Kim, H.S.; Nishimura, Y.; Osada, H.; Sekiya, S.

    2000-01-01

    ICRP recommends age-dependent dose evaluation for intakes of radionuclides by inhalation and ingestion, and gave age-specific biokinetic models and dose coefficients (doses per unit intake) for infants, children and adults in the publications. Dose coefficients are also needed for the assessment of exposures received in utero and after birth by the offspring of the woman who has received intakes of radionuclides. In the model that has been adopted by ICRP, the doses to the developing fetus are calculated using CF/CM values, concentration ratios for radionuclides in the fetus and the maternal tissues. The purpose of this study is to evaluate the CF/CM of each radionuclide by the measurement of element concentration in cord blood and maternal blood. Blood samples were obtained from 35 mothers who delivered in Department of Obstetrics and Gynecology of Chiba University. Just after the delivery, unbiblical cord blood was sampled. Maternal blood was also obtained from the arm vein within 30 minutes after the delivery. The serum was separated from the blood sample with centrifugation. About 50 mg of freezer-dried whole blood and serum were digested with 0.5 ml of 65% ultra-pure nitric acid and 0.2 ml of 30% hydrogen peroxide in a microwave digester. The diluted solutions were used for the determination of elements by ICP-MS (Inductively Coupled Plasma Mass Spectrometry) and ICP-AES (Inductively Coupled Plasma Atomic Emission Spectrometry). The elements determined in these samples included Mg, K, Ca, Mn, Fe, Cu, Zn, Se, Rb, Sr and Cs. The concentration of Cu was higher in the maternal blood than in the cord blood in both whole blood and serum. On the other hand, Mn and Fe were higher in the cord blood. The differences of concentration ratios among elements and the differences among tissues will be discussed. (author)

  6. [Evaluating training programs on occupational health and safety: questionnaire development].

    Science.gov (United States)

    Zhou, Xiao-Yan; Wang, Zhi-Ming; Wang, Mian-Zhen

    2006-03-01

    To develop a questionnaire to evaluate the quality of training programs on occupational health and safety. A questionnaire comprising five subscales and 21 items was developed. The reliability and validity of the questionnaire was tested. Final validation of the questionnaire was undertaken in 700 workers in an oil refining company. The Cronbach's alpha coefficients of the five subscales ranged from 0.6194 to 0.6611. The subscale-scale Pearson correlation coefficients ranged from 0.568 to 0.834 . The theta coefficients of the five subscales were greater than 0.7. The factor loadings of the five subscales in the principal component analysis ranged from 0.731 to 0.855. Use of the questionnaire in the 700 workers produced a good discriminability, with excellent, good, fair and poor comprising 22.2%, 31.2%, 32.4% and 14.1 respectively. Given the fact that 18.7% of workers had never been trained and 29.7% of workers got one-off training only, the training program scored an average of 57.2. The questionnaire is suitable to be used in evaluating the quality of training programs on occupational health and safety. The oil refining company needs to improve training for their workers on occupational health and safety.

  7. [Evaluation of the efficacy of medical screening of blood donors on preventing blood transfusion-transmitted infectious agents].

    Science.gov (United States)

    Seck, M; Dièye, B; Guèye, Y B; Faye, B F; Senghor, A B; Toure, S A; Dieng, N; Sall, A; Toure, A O; Dièye, T N; Diop, S

    2016-05-01

    The aim of this study was to evaluate the efficacy of medical screening to retain blood donors in window period by comparing the seroprevalence of infectious agents (HIV, hepatitis B and C, syphilis) in deferred versus accepted blood donors. This prospective and transversal study was performed during 4 months in the National Blood Transfusion Center in Dakar (Senegal). We conducted a convenience sampling comparing the seroprevalence of infectious agents (HIV, HBsAg, HCV and syphilis) in deferred versus accepted blood donors after medical selection. In total, 8219 blood donors were included. Medical selection had authorized 8048 donors (97.92%) and deferred donors were 171 (2.08%). The prevalence of HIV was higher in the deferred than in accepted blood donors (1.75% vs. 0.05%) (P=0.0003; OR=35.91), as well as for HBsAg (12.87% vs. 7.35%) (P=0.006; OR=1.86). HCV antibodies were present in 0.71% of accepted blood donors and 0.58% in deferred blood donors (P=0.65; OR=0.82). Only accepted donors had brought the infection of syphilis (0.34%) (P=0.56; OR=0). Medical selection is efficient to exclude blood donors at high risk of HIV transmission and to a lesser extent of HBV. However, current medical screening procedures do not allow us to exclude donors asymptomatic carriers of HCV and syphilis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  8. Evaluating a smartphone application to improve child passenger safety and fire safety knowledge and behaviour.

    Science.gov (United States)

    Omaki, Elise; Shields, Wendy C; McDonald, Eileen; Aitken, Mary E; Bishai, David; Case, James; Gielen, Andrea

    2017-02-01

    Although proven measures for reducing injury due to motor vehicle collision and residential fires exist, the number of families properly and consistently using child passenger restraints and smoke alarms remains low. This paper describes the design of the Safety In Seconds (SIS) 2.0 study, which aims to evaluate the impact of a smartphone app on parents' use of child restraints and smoke alarms. SIS is a multisite randomised controlled trial. Participants are parents of children aged 4-7 years who are visiting the Pediatric Emergency Department or Pediatric Trauma Service. Parents are randomised to receive tailored education about child passenger safety or about fire safety via the SIS smartphone app. A baseline and two follow-up surveys at 3 months and 6 months are conducted. Primary outcomes are: (1) having the correct child restraint for the child's age and size; (2) restraining the child in the back seat of the car; (3) buckling the child up for every ride; (4) having the restraint inspected by a child passenger safety technician; (5) having a working smoke alarm on every level of the home; (6) having hard-wired or lithium battery smoke alarms; (7) having and (8) practising a fire escape plan. Finding ways to communicate with parents about child passenger and fire safety continues to be a research priority. This study will contribute to the evidence about how to promote benefits of proper and consistent child restraint and smoke alarm use. NCT02345941; Pre-results. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  9. Safety evaluation review of the prototype license application safety analysis report

    International Nuclear Information System (INIS)

    1991-08-01

    The US Nuclear Regulatory Commission (NRC) staff and consultants reviewed a Prototype License Application Safety Analysis Report (PLASAR) submitted by the US Department of Energy (DOE) for the belowground vault (BGV) alternative method of low-level radioactive waste disposal. In Volume 1 of NUREG-1375, the NRC staff provided the safety review results for an earth-mounded concrete bunker PLASAR. In the current report, the staff focused its review on the design, construction, and operational aspects of the BGV PLASAR. The staff developed review comments and questions using the Standard Review Plan (SRP), Rev. 1 (NUREG-1200) as the basis for evaluating the acceptability of the information provided in the BGV PLASAR. The detailed review comments provided in this report are intended to be useful guidance to facility developers and State regulators in addressing issues likely to be encountered in the review of a license application for a low-level-waste disposal facility. 44 refs

  10. Safety and effects of two red blood cell transfusion strategies in pediatric cardiac surgery patients: a randomized controlled trial

    NARCIS (Netherlands)

    de Gast-Bakker, D. H.; de Wilde, R. B. P.; Hazekamp, M. G.; Sojak, V.; Zwaginga, J. J.; Wolterbeek, R.; de Jonge, E.; Gesink-van der Veer, B. J.

    2013-01-01

    To investigate the safety and effects of a restrictive red blood cell (RBC) transfusion strategy in pediatric cardiac surgery patients. Randomized controlled trial. Pediatric ICU in an academic tertiary care center, Leiden University Medical Center, Leiden, The Netherlands. One hundred seven

  11. Follow-up Evaluation of Air Force Blood Donors Screening Positive for Chagas Disease

    Science.gov (United States)

    2017-08-27

    Blood Donors Screening Positive for Cbagas Disease presented at/published to Military Health System Research Symposium (Florida, 27-30 Aug 2017) in...disease upon blood donation at JBSA -Lackland 6. TITLE OF MATERIAL TO BE PUBLISHED OR PRESENTED: Follow-up evaluation of Air Force blood donors ...Designated Exempt Reviewer Follow-up evaluation of Air Force blood donors screening positive for Chagas disease Joseph Marcus1, Bryant Webber2, Leo Cropper2

  12. Safety evaluation of ventilation networks in case of fire

    International Nuclear Information System (INIS)

    Perdriau, P.; Pourprix, M.; Raboin, S.; Rouyer, J.L.; Tarrago, X.

    1983-01-01

    Several teams from CEA have cooperated to produce a code for modeling ventilation networks under accidental conditions in nuclear facilities. The objective is to study responses to a network to perturbations which are either mechanical or thermal. Such a tool was necessary for safety and protection studies because ventilation network performances are difficult to evaluate when the network gets complex. There was no requirement for a very sophisticated code, considering the margin of error which generally characterizes the ventilation measurements, but this code should be well validated to become a reliable tool for pointing out safety problems at the design stage and during the operating life of the ventilation system. The code has been called PIAF. It solves a set of equations which simulate a ventilation network in a permanent regime

  13. Safety equipment and methods for evaluating its effectiveness

    Energy Technology Data Exchange (ETDEWEB)

    Evdokimov, F I; Nadtoka, T B [DPI (Ukraine)

    1993-05-01

    Analyzes relations between technologies (especially for roof support) used in black coal mining and work safety in mines. The share of manual work and accident rate are compared for mining by narrow and wide web shearer loaders and by coal plows with powered and individual support. Protection from occupational injury is discussed at three levels: safety engineering, work organization and the human factor. A method of evaluating the social and economic effectiveness of protection from occupational injury developed at the DPI institute is presented. The method uses the knowledge of probability distribution of failure situations, failures and protective means to determine the probabilistic characteristics of the functioning of protection systems and to calculate, for a given period, the occurrence probability and mean number of accidents. Each state of the system is characterized by determined social and/or economic results. The method was used in designing equipment intended for protective power cut-off in electric mine networks.

  14. Mark I containment, short term program. Safety evaluation report

    International Nuclear Information System (INIS)

    1977-12-01

    Presented is a Safety Evaluation Report (SER) prepared by the Office of Nuclear Reactor Regulation addressing the Short Term Program (STP) reassessment of the containment systems of operating Boiler Water Reactor (BWR) facilities with the Mark I containment system design. The information presented in this SER establishes the basis for the NRC staff's conclusion that licensed Mark I BWR facilities can continue to operate safely, without undue risk to the health and safety of the public, during an interim period of approximately two years while a methodical, comprehensive Long Term Program (LTP) is conducted. This SER also provides one of the basic foundations for the NRC staff review of the Mark I containment systems for facilities not yet licensed for operation

  15. A guideline for comprehensive evaluation of a licensee's effort to cultivate safety culture

    International Nuclear Information System (INIS)

    Makino, Maomi; Ishii, Yoichi

    2009-01-01

    The nuclear industry in Japan had held excellent performance in safety in the world during 90's. However recent events stem from organizational factors and defects of safety culture are pointed out in their contexts. In order to reduce accidents caused by organizational factors, the Japanese Regulatory body NISA (Nuclear and Industrial Safety Agency) decided to evaluate a licensee's effort for the cultivation of safety culture, and to order all licensses to add the provision of cultivating safety culture to their safety preservation rules. The inspection for the new safety preservation rules started in December, 2007. For a measure of evaluation by resident inspectors, NISA and the Japan Nuclear Energy Safety Organization (JNES) prepared a guideline for the prevention of degradation of safety culture and organizational climate. In this guideline, 14 items were defined as the components of the safety culture or as the viewpoints to evaluate the effort made to prevent any degradation of safety culture and organizational climate in the daily safety preservation activities. The 14 items are also used to establish the method to comprehensively evaluate the effort to prevent degradation of safety culture and organizational climate. This method consists of 10 steps: two steps to taken prior to start of the evaluation, two steps to be taken during the evaluation period, 5 steps to be taken during a comprehensive evaluation period and a final step to be taken for comprehensive findings for safety culture. This paper mainly describes the viewpoints to evaluate comprehensively a licensee's effort for cultivation of safety culture. (author)

  16. Squale: evaluation criteria of functioning safety; Squale: criteres d`evaluation de la surete de fonctionnement

    Energy Technology Data Exchange (ETDEWEB)

    Deswarte, Y; Kaaniche, M [Centre National de la Recherche Scientifique (CNRS), 31 - Toulouse (France). Laboratoire d` Analyse et d` Architecture des Systemes; Corneillie, P [CE2A-DI, 92 - Courbevoie (France); Benoit, P [Matra Transport International, 92 - Montrouge (France)

    1998-05-01

    The SQUALE (security, safety and quality evaluation for dependable systems) project is part of the ACTS (advanced communications, technologies and services) European program. Its aim is to develop confidence evaluation criteria to test the functioning safety of systems. All industrial sectors that use critical applications (nuclear, railway, aerospace..) are concerned. SQUALE evaluation criteria differ from the classical evaluation methods: they are independent of the application domains and industrial sectors, they take into account the overall functioning safety attributes, and they can progressively change according to the level of severity required. In order to validate the approach and to refine the criteria, a first experiment is in progress with the METEOR automatic underground railway and another will be carried out on a telecommunication system developed by Bouygues company. (J.S.) 15 refs.

  17. Evaluation of blood signal in cardiac MR imaging using ''black-blood'' technique

    International Nuclear Information System (INIS)

    Nakanishi, Tadashi; Yamada, Takayuki; Tamura, Akihisa; Miyasaka, Kenji; Kohata, Minako; Ono, Chiaki; Kajima, Toshio; Ito, Katsuhide

    1999-01-01

    Degradation of image quality encountered in cardiac imaging has been attributed to flowing blood signal in the ventricular cavity. To solve this problem, a sequence in which a pair of selective and non-selective inversion pulse in used for a preparation pulse, has been proposed. However, even with this sequence we frequently observed the signal in the blood pool caused by blood itself rather than blood flow. In this article, we investigated the characteristics of those signals. Five healthy normal volunteers and 13 patients with ischemic heart disease were scanned with a 1.5-tesla MR imager. Breath-hold ECG gated fast spin echo with the pair of inversion pulses was performed to obtain cardiac images with T 2 contrast. Typical blood signal appeared as inhomogeneous high intense band adjacent to inner surface of left ventricular apex. At ventricular base, no such signal was encountered even at akinetic myocardium in patients with old myocardial infarction. This signal was observed in all volunteers and 39% of patients. Decrease of TR resulting from tachycardia tended to reduce the blood signal in the left ventricular cavity. Thicker slice section and selective inversion pulse tended to increase the blood signal. Recognition of the signal is essential to differentiate true myocardial infarcts from blood signal, although bright blood imaging like gradient echo or thinner section can partly be helpful. (author)

  18. Safety evaluation report of the Waste Isolation Pilot Plant safety analysis report: Contact-handled transuranic waste disposal operations

    International Nuclear Information System (INIS)

    1997-02-01

    DOE 5480.23, Nuclear Safety Analysis Reports, requires that the US Department of Energy conduct an independent, defensible, review in order to approve a Safety Analysis Report (SAR). That review and the SAR approval basis is documented in this formal Safety Evaluation Report (SER). This SER documents the DOE's review of the Waste Isolation Pilot Plant SAR and provides the Carlsbad Area Office Manager, the WIPP SAR approval authority, with the basis for approving the safety document. It concludes that the safety basis documented in the WIPP SAR is comprehensive, correct, and commensurate with hazards associated with planned waste disposal operations

  19. Criticality Safety Evaluation of Standard Criticality Safety Requirements #1-520 g Operations in PF-4

    Energy Technology Data Exchange (ETDEWEB)

    Yamanaka, Alan Joseph Jr. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-10-13

    Guidance has been requested from the Nuclear Criticality Safety Division (NCSD) regarding processes that involve 520 grams of fissionable material or less. This Level-3 evaluation was conducted and documented in accordance with NCS-AP-004 (Ref. 1), formerly NCS-GUIDE-01. This evaluation is being written as a generic evaluation for all operations that will be able to operate using a 520-gram mass limit. Implementation for specific operations will be performed using a Level 1 CSED, which will confirm and document that this CSED can be used for the specific operation as discussed in NCS-MEMO-17-007 (Ref. 2). This Level 3 CSED updates and supersedes the analysis performed in NCS-TECH-14-014 (Ref. 3).

  20. Renal function evaluation in the aged with normal blood pressure and high blood pressure

    International Nuclear Information System (INIS)

    Jacob Filho, W.; Carvalho Filho, E.T. de; Papaleo Netto, M.; Baptista, M.C.

    1986-01-01

    Thirty-four patients older than 65 years were divided into two groups according to their ages: I - 66 to 74 years (17 patients), II - 75 and over (17 patients). These elderly patients were also divided according to their arterial blood pressure level (BP): A - normal BP (14 patients), B high BP (20 patients). None of these patients presented any other disease that could affect kidney function, nor have used drugs that could interfere on the BP or on the kidney function. Glomerular filtration rate (GFR) and effective renal plasmatic flow (ERPF) were analysed by radioisotopic techniques. Furthermore the filtration fraction (FF) was evaluated by the GFR/ERPF ratio. The observed GFR, ERPF and FF variations in the age groups or in normotensive and hypertensive patients were not significant, but we could assume that the physiopathological mechanisms that cause a decreased GFR in consequence of age or of systemic hypertension could be of different origins. Thus in the old hypertensive patients, alterations in the autoregulated hemodynamic mechanism could occur. (author) [pt

  1. Evaluation of fire probabilistic safety assessment for a PWR plant

    International Nuclear Information System (INIS)

    Wu, C.H.; Lin, T.J.; Kao, T.M.

    2001-01-01

    The internal fire analysis of the level 1 power operation probability safety assessment (PSA) for Maanshan (PWR) Nuclear Power Plant (MNPP) was updated. The fire analysis adopted a scenario-based PSA approach to systematically evaluate fire and smoke hazards and their associated risk impact to MNPP. The result shows that the core damage frequency (CDF) due to fire is about six times lower than the previous one analyzed by the Atomic Energy Council (AEC), Republic of China in 1987. The plant model was modified to reflect the impact of human events and recovery actions during fire. Many tabulated EXCEL spread-sheets were used for evaluation of the fire risk. The fire-induced CDF for MNPP is found to be 2.1 E-6 per year in this study. The relative results of the fire analysis will provide the bases for further risk-informed fire protection evaluation in the near future. (author)

  2. In vitro and in vivo evaluation of efficacy and safety of photoprotective formulations containing antioxidant extracts

    Directory of Open Access Journals (Sweden)

    Maria Cristina P.P. Reis Mansur

    Full Text Available ABSTRACT Chronic exposure to solar radiation could contribute to premature skin aging and skin cancer. Skin presents its own antioxidant defense, however when defenses are out of balance, reactive oxygen species could damage biological structures. In the present work, an oil-in-water photoprotective emulsion was developed and Bauhinia microstachya var. massambabensis Vaz, Fabaceae, extracts at 1% (obtained by extraction with different solvents were added to this emulsion. In vitro and in vivo efficacy and safety of the formulations were evaluated. Spectrophotometric methods and in vivo Colipa test were performed to evaluated efficacy of the formulations, through sun protection factor (SPF determination and UVA protection factor assessment. To the in vitro safety assessment HET-CAM, CAM-TBS and Red Blood Cell tests were performed. Results showed that both extracts contributed to a higher in vivo photoprotection (SPF 18 when compared to the formulation without extract (SPF 13, this result could be attributed to the antioxidant activity of the plant extracts that act by capturing reactive oxygen species. Concerning safety, all formulations were considered non-irritant according to in vitro tests. Formulations containing extracts could be considered efficient and safe for cosmetic use since they presented higher sun protection factor and passed the toxicity tests.

  3. Evaluating and Predicting Patient Safety for Medical Devices With Integral Information Technology

    Science.gov (United States)

    2005-01-01

    323 Evaluating and Predicting Patient Safety for Medical Devices with Integral Information Technology Jiajie Zhang, Vimla L. Patel, Todd R...errors are due to inappropriate designs for user interactions, rather than mechanical failures. Evaluating and predicting patient safety in medical ...the users on the identified trouble spots in the devices. We developed two methods for evaluating and predicting patient safety in medical devices

  4. Evaluation of intelligent transport systems impact on school transport safety

    Directory of Open Access Journals (Sweden)

    Jankowska-Karpa Dagmara

    2017-01-01

    Full Text Available The integrated system of safe transport of children to school using Intelligent Transport Systems was developed and implemented in four locations across Europe under the Safeway2School (SW2S project, funded by the EU. The SW2S system evaluation included speed measurements and an eye-tracking experiment carried out among drivers who used the school bus route, where selected elements of the system were tested. The subject of the evaluation were the following system elements: pedestrian safety system at the bus stop (Intelligent Bus Stop and tags for children, Driver Support System, applications for parents’ and students’ mobile phones, bus stop inventory tool and data server. A new sign designed for buses and bus stops to inform about child transportation/children waiting at the bus stop was added to the system. Training schemes for system users were also provided. The article presents evaluation results of the impact of selected elements of the SW2S system on school transport safety in Poland.

  5. Monopolar radiofrequency treatment of the eyelids: a safety evaluation.

    Science.gov (United States)

    Biesman, Brian S; Pope, Karl

    2007-07-01

    Monopolar radiofrequency (RF) energy has been used to successfully accomplish noninvasive skin tightening of the face, abdomen, and extremities. Owing to concerns about injury to the eye itself, monopolar RF treatment of the eyelids has not been feasible. The objective was to evaluate the safety of a novel 0.25-cm(2)"shallow" treatment tip for noninvasive tightening of eyelid skin. This was a tripartite study that began with an animal model to evaluate soft tissue effects and temperature change at the ocular surface. Findings were then extrapolated to ex vivo evaluation of human eyelids and ultimately to an in vivo human eyelid safety study. The animal studies demonstrated that the 0.25-cm(2) treatment tip could be used safely on eyelids in conjunction with appropriate ocular protection. The ex vivo human eyelid studies confirmed that, at typical treatment settings, the shallow treatment tip did not produce frank eyelid injury. The in vivo human studies confirmed that, at the tested settings, the novel treatment tip did not injure the eyelids or eyes. If used properly, the 0.25-cm(2) treatment tip can be safely used on human eyelids.

  6. Seismic evaluation of safety systems at the Savannah River reactors

    International Nuclear Information System (INIS)

    Hardy, G.S.; Johnson, J.J.; Eder, S.J.; Monahon, T.M.; Ketcham, D.R.

    1989-01-01

    A thorough review of all safety related systems in commercial nuclear power plants was prompted by the accident at the Three Mile Island Nuclear Power Plant. As a consequence of this review, the Nuclear Regulatory Commission (NRC) focused its attention on the environmental and seismic qualification of the industry's electrical and mechanical equipment. In 1980, the NRC issued Unresolved Safety Issue (USI) A-46 to verify the seismic adequacy of the equipment required to safely shut down a plant and maintain a stable condition for 72 hours. After extensive research by the NRC, it became apparent that traditional analysis and testing methods would not be a feasible mechanism to address this USI A-46 issue. The costs associated with utilizing the standard analytical and testing qualification approaches were exorbitant and could not be justified. In addition, the only equipment available to be shake table testing which is similar to the item being qualified is typically the nuclear plant component itself. After 8 years of studies and data collection, the NRC issued its ''Generic Safety Evaluation Report'' approving an alternate seismic qualification approach based on the use of seismic experience data. This experience-based seismic assessment approach will be the basis for evaluating each of the 70 pre-1972 commercial nuclear power units in the United States and for an undetermined number of nuclear plants located in foreign countries. This same cost-effective developed for the commercial nuclear power industry is currently being applied to the Savannah River Production Reactors to address similar seismic adequacy issues. This paper documents the results of the Savannah River Plant seismic evaluating program. This effort marks the first complete (non-trial) application of this state-of-the-art USI A-46 resolution methodology

  7. Seismic evaluation of safety systems at the Savannah River reactors

    International Nuclear Information System (INIS)

    Hardy, G.S.; Johnson, J.J.; Eder, S.J.; Monahon, T.; Ketcham, D.

    1989-01-01

    A thorough review of all safety related systems in commercial nuclear power plants was prompted by the accident at the Three Mile Island Nuclear Power Plant. As a consequence of this review, the Nuclear Regulatory Commission (NRC) focused its attention on the environmental and seismic qualification of the industry's electrical and mechanical equipment. In 1980, the NRC issued Unresolved Safety Issue (USI) A-46 to verify the seismic adequacy of the equipment required to safely shut down a plant and maintain a stable condition for 72 hours. After extensive research by the NRC, it became apparent that traditional analysis and testing methods would not be a feasible mechanism to address this USI A-46 issue. The costs associated with utilizing the standard analytical and testing qualification approaches were exorbitant and could not be justified. In addition, the only equipment available to be shake table tested which is similar to the item being qualified is typically the nuclear plant component itself. After 8 years of studies and data collection, the NRC issued its Generic Safety Evaluation Report approving an alternate seismic qualification approach based on the use of seismic experience data. This experience-based seismic assessment approach will be the basis for evaluating each of the 70 pre-1972 commercial nuclear power units in the US and for an undetermined number of nuclear plants located in foreign countries. This same cost-effective approach developed for the commercial nuclear power industry is currently being applied to the Savannah River Production Reactors to address similar seismic adequacy issues. This paper documents the results of the Savannah River Plant seismic evaluation program. This effort marks the first complete (non-trial) application of this state-of-the-art USI A-46 resolution methodology

  8. Effects and safety of daily ingestion of plum extract on blood pressure: randomized, double-blinded, placebo-controlledparallelgroup comparison study

    Directory of Open Access Journals (Sweden)

    Mie Nishimura

    2017-11-01

    Full Text Available Background: Hypertension is an increasing health issue in Japan. Plums are widely consumed in Japan and are reported to have various health benefits, including improvements to blood flow. However, clinical trials investigating the effects of plum extract on blood pressure have not yet been conducted. Therefore, we evaluated the effects and safety of plum extract on blood pressure in this randomized, double-blinded, and placebo-controlled parallel group comparison study. Methods: Seventy-four healthy Japanese subjects with systolic blood pressure (SBP ≥130 and <160 mmHg were randomly divided into test and placebo groups. Subjects were given either plum extract-processed food (3.0 g of plum extract, containing 30 mg of mumefural and 1.119 g of citric acid or placebo food daily for 12 weeks. Physical examinations, blood measurements, and medical interviews were performed at weeks 0, 4, 8, and 12 and at 2 weeks after the intake period. Results: SBP and diastolic blood pressure (DBP did not significantly differ between the groups. However, in subjects with grade I hypertension, DBP was significantly lower in the active test food group than in the placebo food group at week 12 and at 2 weeks after the intake period. An exploratory subgroup analysis revealed that plum extract improved DBP in subjects with normal to high obesity/class I obesity at week 12. Moreover, plum extract had positive effects on fatigue and bowel movements as determined by visual analog scale questionnaire evaluation. No abnormal changes or severe adverse events were observed in the physical examinations, blood measurements, or medical interviews in this trial. Conclusion: These results suggest that plum extract is safe for long-term intake and improves DBP in subjects with grade I hypertension.

  9. Evaluation of the quality of blood components obtained after automated separation of whole blood by a new multiunit processor

    DEFF Research Database (Denmark)

    Lagerberg, Johan W; Salado-Jimena, Jose A; Löf, Helena

    2013-01-01

    The Reveos system (Terumo BCT) is a fully automated device able to process four whole blood (WB) units simultaneously into a plasma unit, a red blood cell (RBC) unit, and an interim platelet (PLT) unit (IPU). Multiple IPUs can be pooled to form a transfusable PLT product. The aim of our study...... was to evaluate the quality of components made with the Reveos system from either fresh (2-8 hr) or overnight-held WB....

  10. Evaluation of hepatic hemangioma by Tc-99 m red blood cell hepatic blood pool scan

    International Nuclear Information System (INIS)

    Sohn, Myung Hee

    2005-01-01

    Hemangioma is the most common benign tumor of the liver, with a prevalence estimated as high as 7%. Tc-99m red blood cell (RBC) hepatic blood pool scan with single photon emission computed tomography (SPECT) imaging is extremely useful for the confirmation or exclusion of hepatic hemangiomas. The classic finding of absent or decreased perfusion and increased blood pooling ('perfusion/blood pool mismatch') is the key diagnostic element in the diagnosis of hemangiomas. The combination of early arterial flow and delayed blood pooling ('perfusion/blood pool match') is shown uncommonly. In giant hemangioma, filling with radioactivity appears first in the periphery, with progressive central fill-in on sequential RBC blood pool scan. However, the reverse filling pattern, which begins first in the center with progressive peripheral filling, is also rarely seen. Studies with false-positive blood pooling have been reported infrequently in nonhemangiomas, including hemangiosarcoma, hepatocellular carcinoma, hepatic adenoma, and metastatic carcinomas (adenocarcinma of the colon, small cell carcinoma of the lung, neruroendocrine carcinoma). False-negative results have been also reported rarely except for small hemagniomas that are below the limits of spatial resolution of gamma camera

  11. Blood biochemistry evaluation in horses hyperimmune sera production

    Energy Technology Data Exchange (ETDEWEB)

    Baptista, Tatyana S. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Instituto Butantan, Sao Paulo, SP (Brazil); E-mail: proplasma@butantan.gov.br; Zamboni, Cibele [Instituto de Pesquisas Energeticas e Nucleares IPEN/CNEN-SP, Sao Paulo, SP (Brazil); E-mail: czamboni@ipen.br; Marcelino, Jose R.; Freitas, Monica G. [Instituto Butantan, Sao Paulo, SP (Brazil); E-mail: marcelino@butantan.gov.br; mfreitas@uol.com

    2007-07-01

    In the present study the biochemical values for Cl, K and Na in whole blood from health equine used for immunization process were determined using nuclear methodology. The results were compared with human being whole blood estimation permitting a discussion about the similarities between the medium values and the reference intervals taken {+-} 1 and {+-} 2 SD (Standard Deviation). We intend to use these data as interval value for Cl, K and Na in whole blood of equines to perform clinical practical. (author)

  12. Critical evaluation of blood volume measurements during hemodialysis.

    Science.gov (United States)

    Dasselaar, Judith J; van der Sande, Frank M; Franssen, Casper F M

    2012-01-01

    Devices that continuously measure relative blood volume (RBV) changes during hemodialysis (HD) are increasingly used for the prevention of dialysis hypotension and fine-tuning of dry weight. However, RBV measurements are subject to various limitations. First, RBV devices provide information on relative blood volume changes but not on absolute blood volume. Since blood volume varies with the hydration status, identical reductions of RBV may result in very different absolute blood volumes at the end of HD. Second, RBV changes underestimate the change of total blood volume due to translocation of lower-hematocrit blood from the microcirculation to the central circulation. Third, changes in posture before and during HD, food intake, exercise, and administration of intravenous fluids may influence the validity of the RBV measurement. Fourth, results obtained by various RBV devices show large interdevice differences. Finally, although a fall in blood volume is an important factor in dialysis hypotension, frank dialysis hypotension only occurs when the cardiovascular compensatory mechanisms can no longer compensate for the reduction in blood volume. Therefore, the dialysis staff should not exclusively focus on RBV, but also search for opportunities in the dialysis prescription to facilitate cardiovascular compensatory mechanisms, e.g. by lowering dialysate temperature. In the opinion of the authors, routine RBV monitoring should be used with caution until the major conceptual and methodological problems that are inherent to the indirect RBV estimation are clarified. Copyright © 2012 S. Karger AG, Basel.

  13. Evaluating the effectiveness of a logger safety training program.

    Science.gov (United States)

    Bell, Jennifer L; Grushecky, Shawn T

    2006-01-01

    Logger safety training programs are rarely, if ever, evaluated as to their effectiveness in reducing injuries. Workers' compensation claim rates were used to evaluate the effectiveness of a logger safety training program, the West Virginia Loggers' Safety Initiative (LSI). There was no claim rate decline detected in the majority (67%) of companies that participated in all 4 years of the LSI. Furthermore, their rate did not differ from the rest of the WV logging industry that did not participate in the LSI. Worker turnover was significantly related to claim rates; companies with higher turnover of employees had higher claim rates. Companies using feller bunchers to harvest trees at least part of the time had a significantly lower claim rate than companies not using them. Companies that had more inspections per year had lower claim rates. High injury rates persist even in companies that receive safety training; high employee turnover may affect the efficacy of training programs. The logging industry should be encouraged to facilitate the mechanization of logging tasks, to address barriers to employee retention, and to increase the number of in-the-field performance monitoring inspections. Impact on industry There are many states whose logger safety programs include only about 4-8 hours of safe work practices training. These states may look to West Virginia's expanded training program (the LSI) as a model for their own programs. However, the LSI training may not be reaching loggers due to the delay in administering training to new employees and high levels of employee turnover. Regardless of training status, loggers' claim rates decline significantly the longer they work for a company. It may be that high injury rates in the state of West Virginia would be best addressed by finding ways to encourage and facilitate companies to become more mechanized in their harvesting practices, and to increase employee tenure. Increasing the number of yearly performance inspections

  14. An evaluation of safety culture initiatives at BNSF Railway

    Science.gov (United States)

    2015-04-01

    Major safety culture (SC) initiatives initiated in the FRA Office of Research, Technology and Development (RT&D), such as Clear Signal for Action (CSA), the Investigation of Safety Related Occurrences Protocol (ISROP), the Participative Safety Rules ...

  15. Observational Pharmacoepidemiology in the Drug Safety and Effectiveness Evaluation

    Directory of Open Access Journals (Sweden)

    José Cabrita

    2017-04-01

    Full Text Available Observational epidemiological studies have been used in the medicines context for more than 40 years, contributing to characterize drug use patterns and safety, efficacy and effectiveness profiles. Its use has been increased in recognition of the clinical trials limitations to assess the therapeutic and iatrogenic potential of the medicines after its commercialization. The evolution of the regulatory framework for pharmacovigilance, requiring post-marketing studies, post-authorization safety studies (PASS and the post-authorization efficacy studies (PAES to approve certain drugs, reinforced the importance of observational pharmacoepidemiology for the characterization of the medicines safety and effectiveness profiles. Pharmacoepidemiological research can be carried out from field studies designed to obtain the necessary information or in databases with health records of population samples that already contain the information. This 2nd option is more efficient and more and more frequent. Although, observational research from field studies continues to have its space, the increasing availability of databases allowed a new development to observational pharmacoepidemiology. Indeed, access to automated records databases with up-to-date information on medical prescriptions and global health care to representative population samples with long follow-up periods is a valuable tool for the study of drug use patterns and therapeutic and iatrogenic potential in routine clinical practice. In this context, observational pharmacoepidemiology reinforces its role as a scientific area particularly suitable for evaluating the safety and the effectiveness of the medicines in the “real world”, making a relevant contribution to overcome the gap in translating the evidence from the clinical trials for clinical practice.

  16. Follow up Evaluation of Air Force Blood Donors Screening Positive for Chagas Disease

    Science.gov (United States)

    2017-10-05

    59 MDW/SGVU SUBJECT: Professional Presentation Approval 31 JULY2017 Your paper, entitled Follow-up Evaluation of Air Force Blood Donors Screening...PUBLISHED OR PRESENTED: Follow-up Evaluation of Air Force Blood Donors Screening Positive for Chagas Disease 7. FUNDING RECEIVED FOR THIS STUDY? 0...PREVIOUS EDITIONS ARE OBSOLETE 50. DATE Page 3 of 3 Pages Follow-up Evaluation of Air Force Blood Donors Screening Positive for Chagas Disease

  17. Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply risk.

    Science.gov (United States)

    Eyles, John; Heddle, Nancy; Webert, Kathryn; Arnold, Emmy; McCurdy, Bronwen

    2011-08-24

    Examining professional assessments of a blood product recall/withdrawal and its implications for risk and public health, the paper introduces ideas about perceptions of minimal risk and its management. It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study. Interviews with 45 experts from administration, medicine, blood supply, laboratory services and risk assessment took place using a multi-level sampling framework in the aftermath of the recall. These experts either directly dealt with the withdrawal or were involved in the management of the blood supply at the national level. Data from these interviews were coded in NVivo for analysis and interpretation. Analytically, data were interpreted to derive typifications to relate interview responses to risk management heuristics. While all those interviewed agreed on the importance of patient safety, differences in the ways in which the risk was contextualized and explicated were discerned. Risk was seen in terms of patient safety, liability or precaution. These different risk logics are illustrated by selected quotations. Expert assessments did not fully converge and it is possible that these different risk logics and discourses may affect the risk management process more generally, although not necessarily in a negative way. Patient safety is not to be compromised but management of blood risk in publicly funded systems may vary. We suggest ways of managing blood risk using formal and safety case approaches.

  18. Do expert assessments converge? An exploratory case study of evaluating and managing a blood supply risk

    Directory of Open Access Journals (Sweden)

    Arnold Emmy

    2011-08-01

    Full Text Available Abstract Background Examining professional assessments of a blood product recall/withdrawal and its implications for risk and public health, the paper introduces ideas about perceptions of minimal risk and its management. It also describes the context of publicly funded blood transfusion in Canada and the withdrawal event that is the basis of this study. Methods Interviews with 45 experts from administration, medicine, blood supply, laboratory services and risk assessment took place using a multi-level sampling framework in the aftermath of the recall. These experts either directly dealt with the withdrawal or were involved in the management of the blood supply at the national level. Data from these interviews were coded in NVivo for analysis and interpretation. Analytically, data were interpreted to derive typifications to relate interview responses to risk management heuristics. Results While all those interviewed agreed on the importance of patient safety, differences in the ways in which the risk was contextualized and explicated were discerned. Risk was seen in terms of patient safety, liability or precaution. These different risk logics are illustrated by selected quotations. Conclusions Expert assessments did not fully converge and it is possible that these different risk logics and discourses may affect the risk management process more generally, although not necessarily in a negative way. Patient safety is not to be compromised but management of blood risk in publicly funded systems may vary. We suggest ways of managing blood risk using formal and safety case approaches.

  19. Evaluation of the agreement among three handheld blood glucose meters and a laboratory blood analyzer for measurement of blood glucose concentration in Hispaniolan Amazon parrots (Amazona ventralis).

    Science.gov (United States)

    Acierno, Mark J; Mitchell, Mark A; Schuster, Patricia J; Freeman, Diana; Sanchez-Migallon Guzman, David; Tully, Thomas N

    2009-02-01

    To determine the degree of agreement between 3 commercially available point-of-care blood glucose meters and a laboratory analyzer for measurement of blood glucose concentrations in Hispaniolan Amazon parrots (Amazona ventralis). 20 healthy adult Hispaniolan Amazon parrots. A 26-gauge needle and 3-mL syringe were used to obtain a blood sample (approx 0.5 mL) from a jugular vein of each parrot. Small volumes of blood (0.6 to 1.5 microL) were used to operate each of the blood glucose meters, and the remainder was placed into lithium heparin microtubes and centrifuged. Plasma was harvested and frozen at -30 degrees C. Within 5 days after collection, plasma samples were thawed and plasma glucose concentrations were measured by means of the laboratory analyzer. Agreement between pairs of blood glucose meters and between each blood glucose meter and the laboratory analyzer was evaluated by means of the Bland-Altman method, and limits of agreement (LOA) were calculated. None of the results of the 3 blood glucose meters agreed with results of the laboratory analyzer. Each point-of-care blood glucose meter underestimated the blood glucose concentration, and the degree of negative bias was not consistent (meter A bias, -94.9 mg/dL [LOA, -148.0 to -41.7 mg/dL]; meter B bias, -52 mg/dL [LOA, -107.5 to 3.5 mg/dL]; and meter C bias, -78.9 mg/dL [LOA, -137.2 to -20.6 mg/dL]). On the basis of these results, use of handheld blood glucose meters in the diagnosis or treatment of Hispaniolan Amazon parrots and other psittacines cannot be recommended.

  20. Central line-associated bloodstream infections in adult hematology patients with febrile neutropenia: an evaluation of surveillance definitions using differential time to blood culture positivity.

    Science.gov (United States)

    Freeman, Joshua T; Elinder-Camburn, Anna; McClymont, Catherine; Anderson, Deverick J; Bilkey, Mary; Williamson, Deborah A; Berkahn, Leanne; Roberts, Sally A

    2013-01-01

    We used differential time to positivity between central and peripheral blood cultures to evaluate the positive predictive value (PPV) of the National Healthcare Safety Network central line-associated bloodstream infection (CLABSI) surveillance definition among hematology patients with febrile neutropenia. The PPV was 27.7%, which suggests that, when the definition is applied to this population, CLABSI rates will be substantially overestimated.

  1. Review on the Evaluation System of Public Safety Carrying Capacity about Small Town Community

    Institute of Scientific and Technical Information of China (English)

    Ming; SUN; Tianyu; ZHU

    2014-01-01

    Recently,small town community public safety problem has been increasingly highlighted,but its research is short on public safety carrying capacity. Through the investigation and study of community public safety carrying capacity,this paper analyzes the problem of community public safety in our country,to construct index evaluation system of public safety carrying capacity in small town community. DEA method is used to evaluate public safety carrying capacity in small town community,to provide scientific basis for the design of support and standardization theory about small town community in public safety planning.

  2. Evaluation of seven in vitro alternatives for ocular safety testing.

    Science.gov (United States)

    Bruner, L H; Kain, D J; Roberts, D A; Parker, R D

    1991-07-01

    Seven in vitro assays were evaluated to determine if any were useful as screening procedures in ocular safety assessment. Seventeen test materials (chemicals, household cleaners, hand soaps, dishwashing liquids, shampoos, and liquid laundry detergents) were tested in each assay. In vivo ocular irritation scores for the materials were obtained from existing rabbit low volume eye test (LVET) data. The seven assays evaluated included the silicon microphysiometer (SM), luminescent bacteria toxicity test (LBT), neutral red assay (NR), total protein assay (TP), Tetrahymena thermophila motility assay (TTMA), bovine eye/chorioallantoic membrane assay (BE/CAM), and the EYTEX system (ETS). For the seventeen materials used in this study there was a significant correlation between the in vivo irritant potential and in vitro data for all the tests except the EYTEX System (SM, r = -0.87; LBT, r = -0.91; NR, r = -0.85; TTMA, r = 0.78; TP, r = -0.86; ETS, r = 0.29). The irritation classifications provided by the BE/CAM also did not correspond with the actual in vivo irritancy potential of the test materials. The result of this study suggested it may be possible to classify materials into broad irritancy categories with some of the assays. This would allow their use as screens prior to limited in vivo confirmation in the ocular safety assessment process.

  3. Multimethods approach to safety-parameter-display evaluation

    International Nuclear Information System (INIS)

    Banks, W.W.; Blackman, H.S.; Gertman, D.I.; Petersen, R.J.

    1982-01-01

    The Human Factors Engineering Office of EG and G Idaho performed this NRC-funded study to assist the NRC in objectively assessing licensee-developed safety parameter display (SPD) formats and designs. The purpose of this study was to quantitatively measure the degree to which a tachistoscopic method of display evaluation would correlate with the results of a multidimensional rating approach to display evaluation. Results of the following three experiments will be presented; (a) tachistoscopic, (b) multidimensional rating scale, and (c) the combined results of a and b. The test material for all experiments consisted of three multivariate data display formats all under development as SPDs for reactor control rooms presenting safety parameter display data at the loss-of-fluid test (LOFT) facility. The three display formats studied were stars, deviation bar graphs, and meters. Eighteen adult volunteers were used as subjects. All were currently qualified reactor operators from the LOFT reactor plant, with a mean of 9.4 years reactor operating experience

  4. Meat Safety: An Evaluation of Portuguese Butcher Shops.

    Science.gov (United States)

    Santos, Ana; Cardoso, Margarida Fonseca; Costa, José M Correia da; Gomes-Neves, Eduarda

    2017-07-01

    Butcher shops are end points in the meat chain, and they can have a determinant role in cross-contamination control. This study aims to determine whether Portuguese butcher shops comply with European and Portuguese law regarding the sale of fresh meat and meat products. Butcher shops (n = 73) were assessed for meat handler and facility hygiene and for maintenance of the premises. Handlers (n = 88) were given a questionnaire composed of questions about knowledge and practice, including hazard analysis and critical control point (HACCP) and good practice in food industry, to assess their knowledge of and compliance with food safety practices. A checklist of 27 items was used to evaluate facility and meat handler hygiene and butcher shop maintenance. Our results revealed some lack of compliance in all the areas evaluated. The mean knowledge and practice score among the operators was 68.0%, and the mean "visual inspection" score for the butcher shops was 64.0%. Severe deficiencies were observed in the mandatory implementation of HACCP principles in this type of small food business. These findings indicate a need to modify training to enhance compliance with European food safety regulations at this step of the meat chain.

  5. Evaluation of the return rate of volunteer blood donors

    Directory of Open Access Journals (Sweden)

    Adriana de Fátima Lourençon

    2011-06-01

    Full Text Available BACKGROUND: To convert first-time blood donors into regular volunteer donors is a challenge to transfusion services. OBJECTIVES: This study aims to estimate the return rate of first time donors of the Ribeirão Preto Blood Center and of other blood centers in its coverage region. METHODS: The histories of 115,553 volunteer donors between 1996 and 2005 were analyzed. Statistical analysis was based on a parametric long-term survival model that allows an estimation of the proportion of donors who never return for further donations. RESULTS: Only 40% of individuals return within one year after the first donation and 53% return within two years. It is estimated that 30% never return to donate. Higher return rates were observed among Black donors. No significant difference was found in non-return rates regarding gender, blood type, Rh blood group and blood collection unit. CONCLUSIONS: The low percentage of first-time donors who return for further blood donation reinforces the need for marketing actions and strategies aimed at increasing the return rates.

  6. Non-clinical safety evaluation of intranasal iota-carrageenan.

    Science.gov (United States)

    Hebar, Alexandra; Koller, Christiane; Seifert, Jan-Marcus; Chabicovsky, Monika; Bodenteich, Angelika; Bernkop-Schnürch, Andreas; Grassauer, Andreas; Prieschl-Grassauer, Eva

    2015-01-01

    Carrageenan has been widely used as food additive for decades and therefore, an extended oral data set is available in the public domain. Less data are available for other routes of administration, especially intranasal administration. The current publication describes the non-clinical safety and toxicity of native (non-degraded) iota-carrageenan when applied intranasally or via inhalation. Intranasally applied iota-carrageenan is a topically applied, locally acting compound with no need of systemic bioavailability for the drug's action. Animal experiments included repeated dose local tolerance and toxicity studies with intranasally applied 0.12% iota-carrageenan for 7 or 28 days in New Zealand White rabbits and nebulized 0.12% iota-carrageenan administered to F344 rats for 7 days. Permeation studies revealed no penetration of iota-carrageenan across nasal mucosa, demonstrating that iota-carrageenan does not reach the blood stream. Consistent with this, no relevant toxic or secondary pharmacological effects due to systemic exposure were observed in the rabbit or rat repeated dose toxicity studies. Data do not provide any evidence for local intolerance or toxicity, when carrageenan is applied intranasally or by inhalation. No signs for immunogenicity or immunotoxicity have been observed in the in vivo studies. This is substantiated by in vitro assays showing no stimulation of a panel of pro-inflammatory cytokines by iota-carrageenan. In conclusion, 0.12% iota-carrageenan is safe for clinical use via intranasal application.

  7. Non-clinical safety evaluation of intranasal iota-carrageenan.

    Directory of Open Access Journals (Sweden)

    Alexandra Hebar

    Full Text Available Carrageenan has been widely used as food additive for decades and therefore, an extended oral data set is available in the public domain. Less data are available for other routes of administration, especially intranasal administration. The current publication describes the non-clinical safety and toxicity of native (non-degraded iota-carrageenan when applied intranasally or via inhalation. Intranasally applied iota-carrageenan is a topically applied, locally acting compound with no need of systemic bioavailability for the drug's action. Animal experiments included repeated dose local tolerance and toxicity studies with intranasally applied 0.12% iota-carrageenan for 7 or 28 days in New Zealand White rabbits and nebulized 0.12% iota-carrageenan administered to F344 rats for 7 days. Permeation studies revealed no penetration of iota-carrageenan across nasal mucosa, demonstrating that iota-carrageenan does not reach the blood stream. Consistent with this, no relevant toxic or secondary pharmacological effects due to systemic exposure were observed in the rabbit or rat repeated dose toxicity studies. Data do not provide any evidence for local intolerance or toxicity, when carrageenan is applied intranasally or by inhalation. No signs for immunogenicity or immunotoxicity have been observed in the in vivo studies. This is substantiated by in vitro assays showing no stimulation of a panel of pro-inflammatory cytokines by iota-carrageenan. In conclusion, 0.12% iota-carrageenan is safe for clinical use via intranasal application.

  8. [Efficacy and Safety Evaluation of Bushen Shuji Granule in Treating Ankylosing Spondylitis Patients: a Clinical Study].

    Science.gov (United States)

    Kong, Wei-ping; Tao, Qing-wen; Zhang, Ying-ze; Yang, Shu; Xu, Yuan; Zhu, Xiao-xia; Jin, Yue; Yang, Wen-xue; Yan, Xiao-ping

    2015-06-01

    To evaluate the short-term efficacy and safety of Bushen Shuji Granule (BSG) in treating ankylosing spondylitis (AS) patients. A prospective randomized controlled clinical trial was carried out in 62 active stage AS patients with Shen deficiency Du-channel cold syndrome (SDDCS), who were randomly assigned to the BSG group (treated with BSG) and the control group (treated with Celecoxib Capsule). Twelve weeks consisted of one therapeutic course. Therapeutic effects were evaluated by ASAS20 and ASAS40 (set by Assessments in Ankylosing Spondylitis working group) , BASDA150, Chinese medical (CM) syndrome efficacy evaluation standards. BASDAI, the Bath Ankylosing Spondylitis Functional Index (BASFI), the Bath AS Metrology Index (BASMI), scores for spine pain, scores for pain at night, patient global assessment (PGA) , erythrocyte sedimentation rate (ESR) , and C reactive protein (CRP) were observed before and after treatment. After three-month treatment by BSG, ASAS20 standard rate was 63. 33% (19/30 cases) in the BSG group and 66.67% (20/30 cases) in the control group with no significant difference between the two groups (χ2 = 0.073, P > 0.05). The efficacy for CM syndromes was 70.00% (21/30 cases) in the BSG group, higher than that in the control group [40.00% (12/30 cases), χ2 = 5.455, P channel strengthening, blood activating, and channels dredging method had good short-term clinical efficacy and safety in treating AS.

  9. Evaluation of empirical treatment for blood culture-negative endocarditis.

    Science.gov (United States)

    Menu, Estelle; Gouriet, Frédérique; Casalta, Jean-Paul; Tissot-Dupont, Hervé; Vecten, Maude; Saby, Ludivine; Hubert, Sandrine; Salaun, Erwan; Theron, Alexis; Grisoli, Dominique; Lavoute, Cécile; Collart, Frédéric; Habib, Gilbert; Raoult, Didier

    2017-01-01

    Much progress has been made in understanding the main causes of blood culture-negative endocarditis (BCNE). Few studies concerning BCNE treatment (due to previous antibiotics used or fastidious pathogens) are available. We performed this study to evaluate the effectiveness of our therapeutic protocol in BCNE, based on compliance with the protocol, outcome and 1 year mortality. We collected prospectively and analysed retrospectively cases of BCNE between 2002 and 2014, using a simplified and standardized protocol developed by our multidisciplinary team. We apply two kinds of protocols to treat BCNE, which include only four intravenous antimicrobial agents: amoxicillin, vancomycin, gentamicin and amphotericin B. We had 177 patients with definite BCNE. There were 154 (87.0%) patients treated with both appropriate antimicrobial agents and appropriate duration of treatment. We analysed the causes of inappropriate treatment in 13 (7.3%) cases and inappropriate duration in 10 (5.6%) cases. The treatment changes were justified in all cases except one of discharge against medical advice. The fatality rate was 5.1% (nine cases) and all deaths occurred in the group of patients who were treated with appropriate treatment; however, four deaths were not attributable to empirical treatment failure. Concerning the other deaths, the lack of surgical management, in association with empirical treatment, could explain our protocol's failure, such as poorly tolerated surgery. Our protocol is efficient and our mortality rate was low, compared with the literature review. This may result from a strategy that uses a sampling procedure and a standardized protocol at the same time. © The Author 2016. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  10. Normative evaluation of blood banks in the Brazilian Amazon region in respect to the prevention of transfusion-transmitted malaria

    Directory of Open Access Journals (Sweden)

    Daniel Roberto Coradi Freitas

    2014-12-01

    Full Text Available Objective:To evaluate blood banks in the Brazilian Amazon region with regard to structure and procedures directed toward the prevention of transfusion-transmitted malaria (TTM.Methods:This was a normative evaluation based on the Brazilian National Health Surveillance Agency (ANVISA Resolution RDC No. 153/2004. Ten blood banks were included in the study and classified as 'adequate' (≥80 points, 'partially adequate' (from 50 to 80 points, or 'inadequate' (<50 points. The following components were evaluated: 'donor education' (5 points, 'clinical screening' (40 points, 'laboratory screening' (40 points and 'hemovigilance' (15 points.Results:The overall median score was 49.8 (minimum = 16; maximum = 78. Five blood banks were classified as 'inadequate' and five as 'partially adequate'. The median clinical screening score was 26 (minimum = 16; maximum = 32. The median laboratory screening score was 20 (minimum = 0; maximum = 32. Eight blood banks performed laboratory tests for malaria; six tested all donations. Seven used thick smears, but only one performed this procedure in accordance with Ministry of Health requirements. One service had a Program of External Quality Evaluation for malaria testing. With regard to hemovigilance, two institutions reported having procedures to detect cases of transfusion-transmitted malaria.Conclusion:Malaria is neglected as a blood–borne disease in the blood banks of the Brazilian Amazon region. None of the institutions were classified as 'adequate' in the overall classification or with regard to clinical screening and laboratory screening. Blood bank professionals, the Ministry of Health and Health Surveillance service managers need to pay more attention to this matter so that the safety procedures required by law are complied with.

  11. KHNP Safety Culture Framework based on Global Standard, and Lessons learned from Safety Culture Evaluation

    International Nuclear Information System (INIS)

    Kim, Younggab; Hur, Nam Young; Jeong, Hyeon Jong

    2015-01-01

    In order to eliminate the vague fears of the people about the nuclear power and operate continuously NPPs, a strong safety culture of NPPs should be demonstrated. Strong safety culture awareness of workers can overcome social distrust about NPPs. KHNP has been a variety efforts to improve and establish safety culture of NPPs. Safety culture framework applying global standards was set up and safety culture assessment has been carried out periodically to enhance safety culture of workers. In addition, KHNP developed various safety culture contents and they are being used in NPPs by workers. As a result of these efforts, safety culture awareness of workers is changed positively and the safety environment of NPPs is expected to be improved. KHNP makes an effort to solve areas for improvement derived from safety culture assessment. However, there are some areas to take a long time in completing the work. Therefore, these actions are necessary to be carried out consistently and continuously. KHNP also developed recently safety culture enhancement system based on web. All information related to safety culture in KHNP will be shared through this web system and this system will be used to safety culture assessment. In addition to, KHNP plans to develop safety culture indicators for monitoring the symptoms of safety culture weakening

  12. KHNP Safety Culture Framework based on Global Standard, and Lessons learned from Safety Culture Evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Younggab; Hur, Nam Young; Jeong, Hyeon Jong [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2015-05-15

    In order to eliminate the vague fears of the people about the nuclear power and operate continuously NPPs, a strong safety culture of NPPs should be demonstrated. Strong safety culture awareness of workers can overcome social distrust about NPPs. KHNP has been a variety efforts to improve and establish safety culture of NPPs. Safety culture framework applying global standards was set up and safety culture assessment has been carried out periodically to enhance safety culture of workers. In addition, KHNP developed various safety culture contents and they are being used in NPPs by workers. As a result of these efforts, safety culture awareness of workers is changed positively and the safety environment of NPPs is expected to be improved. KHNP makes an effort to solve areas for improvement derived from safety culture assessment. However, there are some areas to take a long time in completing the work. Therefore, these actions are necessary to be carried out consistently and continuously. KHNP also developed recently safety culture enhancement system based on web. All information related to safety culture in KHNP will be shared through this web system and this system will be used to safety culture assessment. In addition to, KHNP plans to develop safety culture indicators for monitoring the symptoms of safety culture weakening.

  13. Is the area under blood pressure curve the best parameter to evaluate 24-h ambulatory blood pressure monitoring data?

    Science.gov (United States)

    Nobre, Fernando; Mion, Décio

    2005-10-01

    Ambulatory blood pressure monitoring (ABPM) provides relevant data about blood pressure over a 24-h period. The analysis of parameters to determine the blood pressure profile from these data is of great importance. To calculate areas under systolic and diastolic blood pressure curves (SBP-AUC/DBP-AUC) and compare with systolic and diastolic blood pressure load (SBPL/DBPL) and 24-h systolic and diastolic blood pressure (24-h SBP/24-h DBP) in order to determine which provides the best correlation with left ventricular mass index (LVMI). ABPM measurements (1143 individuals) were analyzed to obtain 24-h SBP/24-h DBP, SBPL/DBPL, and SBP-AUC/ DBP-AUC, using Spacelabs (90207) and CardioSistemas devices. Left ventricular mass was determined using an echocardiograph HP Sonos 5500 and LVMI was calculated. The correlations between all possible pairs within the group 24-h SBP/SBPL/SBP-AUC and 24-h DBP/DBPL/DBP-AUC were high and statistically significant. The correlations between 24-h SBP/24-h DBP and SBP-AUC/DBP-AUC with SBPL/DBPL close to 100%, were lower than those mentioned above. The correlations of the parameters obtained by ABPM with LVMI were also high and statistically significant, except for blood pressure load between 90 and 100%, and for 24-h SBP of 135 mmHg or less and SBPL higher than 50%. SBPL/DBPL and SBP-AUC/DBP-AUC can be used for the evaluation of ABPM data owing to the strong correlation with 24-h SBP/24-h DBP and with LVMI, except when SBPL is close to 100% or 24-h SBP is below 135 mmHg but SBPL is above 50%. SBP-AUC/DBP-AUC, however, are a better alternative because they do not have the limitations of blood pressure load or even of 24-h blood pressure present.

  14. Safety analysis and evaluation of the next fusion device

    International Nuclear Information System (INIS)

    Kobayashi, Shigetada; Honda, Tsutomu; Ohmura, Hiroshi; Kawai, Masayoshi; Shimizu, Takeshi; Yamaoka, Mitsuaki; Nakahara, Katsuhiko; Seki, Yasushi.

    1988-12-01

    As a part of safety evaluation, a probabilistic risk assessment (PRA) has been attempted for the Next Fusion Device system. Among the various events related to safety, a number of representative events have been selected for assessment, from the events in normal operation state, repair and maintenance state and accidental state. In the first chapter, in order to conduct the probabilistic risk assessment of the whole Fusion Experimental Reactor (FER), the data base required for the analysis was investigated in 1.1, the results on the failure mode and effects analysis (FMEA), accident sequence, radioactive inventory leakage flow path, event tree analysis (ETA) and fault tree analysis (FTA) were summarized in 1.2 to 1.5, respectively. Based on these results, accident initiating events were evaluated in 1.6, and overall risk was assessed in 1.7 and the tasks for the future were summarized in 1.8. It is important to analyze and evaluate various events during normal operations, repair and maintenance and accidents. However, due to the large uncertainties in the modeling of phenomena or the data base, there are many events for which realistic analyses are difficult. Three such events were selected and studied in chapter two. In 2.1, the temperature rise in the reactor structure after the Loss-of-Coolant-Accident caused by the decay heat under various heat removal conditions were investigated. In 2.2, the radiation dose of personnel during repair and maintenance period caused by the release of activated dust were estimated. Lastly, in 2.3 tritium behavior in the stainless steel first wall and graphite armour were studied. (author)

  15. 75 FR 61143 - Meeting of the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2010-10-04

    ... and availability of the blood supply and blood products, (2) broad public health, ethical and legal... availability of various economic factors affecting product cost and supply. In keeping with its established...

  16. Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss

    NARCIS (Netherlands)

    Manshanden, Johan S. J.; Gielen, Chantal L. I.; de Borgie, Corianne A. J. M.; Klautz, Robert J. M.; de Mol, Bas A. J. M.; Koolbergen, David R.

    2015-01-01

    Background: Prolonged or excessive blood loss is a common complication after cardiac surgery. Blood remnants and clots, remaining in the pericardial space in spite of chest tube drainage, induce high fibrinolytic activity that may contribute to bleeding complications. Continuous postoperative

  17. Evaluation of Relative Blood Viscosity During Menstruation in ...

    African Journals Online (AJOL)

    USER

    ABSTRACT. The changes in blood viscosity, plasma viscosity, haematocrit and erythrocyte sedimentation rate before ... higher (6.78±0.18mm/hr) during the menstrual phase than during the premenstrual phase ... MATERIALS AND METHODS.

  18. 29 CFR 1960.79 - Self-evaluations of occupational safety and health programs.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Self-evaluations of occupational safety and health programs. 1960.79 Section 1960.79 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... AND HEALTH PROGRAMS AND RELATED MATTERS Evaluation of Federal Occupational Safety and Health Programs...

  19. 29 CFR 1960.11 - Evaluation of occupational safety and health performance.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Evaluation of occupational safety and health performance. 1960.11 Section 1960.11 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH... AND HEALTH PROGRAMS AND RELATED MATTERS Administration § 1960.11 Evaluation of occupational safety and...

  20. Guidelines for preparing criticality safety evaluations at Department of Energy non-reactor nuclear facilities

    International Nuclear Information System (INIS)

    1993-11-01

    This document contains guidelines that should be followed when preparing Criticality Safety Evaluations that will be used to demonstrate the safety of operations performed at DOE non-reactor nuclear facilities. Adherence to these guidelines will provide consistency and uniformity in criticality safety evaluations (CSEs) across the complex and will document compliance with the requirements of DOE Order 5480.24

  1. Criticality safety evaluation report for K Basin filter cartridges

    International Nuclear Information System (INIS)

    Schwinkendorf, K.N.

    1995-01-01

    A criticality safety evaluation of the K Basin filter cartridge assemblies has been completed to support operations without a criticality alarm system. The results show that for normal operation, the filter cartridge assembly is far below the safety limit of k eff = 0.95, which is applied to plutonium systems at the Hanford Site. During normal operating conditions, uranium, plutonium, and fission and corrosion products in solution are continually accumulating in the available void spaces inside the filter cartridge medium. Currently, filter cartridge assemblies are scheduled to be replaced at six month intervals in KE Basin, and at one year intervals in KW Basin. According to available plutonium concentration data for KE Basin and data for the U/Pu ratio, it will take many times the six-month replacement time for sufficient fissionable material accumulation to take place to exceed the safety limit of k eff = 0.95, especially given the conservative assumption that the presence of fission and corrosion products is ignored. Accumulation of sludge with a composition typical of that measured in the sand filter backwash pit will not lead to a k eff = 0.95 value. For off-normal scenarios, it would require at least two unlikely, independent, and concurrent events to take place before the k eff = 0.95 limit was exceeded. Contingencies considered include failure to replace the filter cartridge assemblies at the scheduled time resulting in additional buildup of fissionable material, the loss of geometry control from the filter cartridge assembly breaking apart and releasing the individual filter cartridges into an optimal configuration, and concentrations of plutonium at U/Pu ratios less than measured data for KE Basin, typically close to 400 according to extensive measurements in the sand filter backwash pit and plutonium production information

  2. Performance and safety of femoral central venous catheters in pediatric autologous peripheral blood stem cell collection.

    Science.gov (United States)

    Cooling, Laura; Hoffmann, Sandra; Webb, Dawn; Yamada, Chisa; Davenport, Robertson; Choi, Sung Won

    2017-12-01

    Autologous peripheral blood hematopoietic progenitor cell collection (A-HPCC) in children typically requires placement of a central venous catheter (CVC) for venous access. There is scant published data regarding the performance and safety of femoral CVCs in pediatric A-HPCC. Seven-year, retrospective study of A-HPCC in pediatric patients collected between 2009 and January 2017. Inclusion criteria were an age ≤ 21 years and A-HPCC using a femoral CVC for venous access. Femoral CVC performance was examined by CD34 collection rate, inlet rate, collection efficiency (MNC-FE, CD34-FE), bleeding, flow-related adverse events (AE), CVC removal, and product sterility testing. Statistical analysis and graphing were performed with commercial software. A total of 75/119 (63%) pediatric patients (median age 3 years) met study criteria. Only 16% of children required a CVC for ≥ 3 days. The CD34 collect rate and CD34-FE was stable over time whereas MNC-FE decreased after day 4 in 80% of patients. CD34-FE and MNC-FE showed inter- and intra-patient variability over time and appeared sensitive to plerixafor administration. Femoral CVC showed fewer flow-related AE compared to thoracic CVC, especially in pediatric patients (6.7% vs. 37%, P = 0.0005; OR = 0.12 (95%CI: 0.03-0.45). CVC removal was uneventful in 73/75 (97%) patients with hemostasis achieved after 20-30 min of pressure. In a 10-year period, there were no instances of product contamination associated with femoral CVC colonization. Femoral CVC are safe and effective for A-HPCC in young pediatric patients. Femoral CVC performance was maintained over several days with few flow-related alarms when compared to thoracic CVCs. © 2017 Wiley Periodicals, Inc.

  3. Evaluation of Peripheral Blood and Cord Blood Platelet Lysates in Isolation and Expansion of Multipotent Mesenchymal Stromal Cells

    Directory of Open Access Journals (Sweden)

    Ioanna Christou

    2018-02-01

    Full Text Available Background: Multipotent Mesenchymal Stromal Cells (MSCs are used in tissue engineering and regenerative medicine. The in vitro isolation and expansion of MSCs involve the use of foetal bovine serum (FBS. However, many concerns have been raised regarding the safety of this product. In this study, alternative additives derived either from peripheral or cord blood were tested as an FBS replacement. Methods: Platelet lysates (PL from peripheral and cord blood were used for the expansion of MSCs. The levels of growth factors in peripheral blood (PB and cord blood (CB PLs were determined using the Multiple Reaction Monitoring (MRM. Finally, the cell doubling time (CDT, tri-lineage differentiation and phenotypic characterization of the MSCs expanded with FBS and PLs were determined. Results: MSCs treated with culture media containing FBS and PB-PL, were successfully isolated and expanded, whereas MSCs treated with CB-PL could not be maintained in culture. Furthermore, the MRM analysis yielded differences in growth factor levels between PB-PL and CB-PL. In addition, the MSCs were successfully expanded with FBS and PB-PL and exhibited tri-lineage differentiation and stable phenotypic characteristics. Conclusion: PB-PL could be used as an alternative additive for the production of MSCs culture medium applied to xenogeneic-free expansion and maintenance of MSCs in large scale clinical studies.

  4. SRTC criticality safety technical review: Nuclear Criticality Safety Evaluation 93-04 enriched uranium receipt

    International Nuclear Information System (INIS)

    Rathbun, R.

    1993-01-01

    Review of NMP-NCS-930087, open-quotes Nuclear Criticality Safety Evaluation 93-04 Enriched Uranium Receipt (U), July 30, 1993, close quotes was requested of SRTC (Savannah River Technology Center) Applied Physics Group. The NCSE is a criticality assessment to determine the mass limit for Engineered Low Level Trench (ELLT) waste uranium burial. The intent is to bury uranium in pits that would be separated by a specified amount of undisturbed soil. The scope of the technical review, documented in this report, consisted of (1) an independent check of the methods and models employed, (2) independent HRXN/KENO-V.a calculations of alternate configurations, (3) application of ANSI/ANS 8.1, and (4) verification of WSRC Nuclear Criticality Safety Manual procedures. The NCSE under review concludes that a 500 gram limit per burial position is acceptable to ensure the burial site remains in a critically safe configuration for all normal and single credible abnormal conditions. This reviewer agrees with that conclusion

  5. In vitro and in vivo safety evaluation of Acer tegmentosum.

    Science.gov (United States)

    Hwang, Youn-Hwan; Park, Hwayong; Ma, Jin Yeul

    2013-06-21

    Acer tegmentosum, which contains salidroside and tyrosol, has been used for the treatment of hepatic disorders in eastern Asia. However, little is known about its safety. To determine the safety of Acer tegmentosum, we evaluated its acute oral toxicity and genotoxicity profiles. Salidroside and tyrosol present in Acer tegmentosum were quantified using high-performance liquid chromatography. Acute oral toxicity testing of Acer tegmentosum was performed in rats. Genotoxicity of Acer tegmentosum was assessed by bacterial reverse mutation, chromosomal aberration, and bone marrow micronucleus tests. All the tests were conducted in accordance with the good laboratory practices. The amounts of salidroside and tyrosol in Acer tegmentosum were found to be 85.01±1.21mg/g and 3.12±0.04mg/g, respectively. In the bacterial reverse mutation test, Acer tegmentosum increased the number of revertant Salmonella typhimurium TA98 colonies, regardless of metabolic activation by S9 mixture. In contrast, Acer tegmentosum application did not significantly increase the number of chromosomal aberrations in Chinese hamster ovary (CHO)-K1 cells and micronucleated polychromatic erythrocytes in mice. In the acute oral toxicity test, the median lethal dose (LD50) of Acer tegmentosum was found to be >2000mg/kg in rats. Take together, Acer tegmentosum exhibits mutagenicity, which was evident from the bacterial reverse mutation test. Further studies are needed to identify the components responsible for such an effect and the underlying mechanisms. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

  6. Economic evaluation of occupational safety preventive measures in a hospital.

    Science.gov (United States)

    Ramos, Delfina G; Arezes, Pedro M; Afonso, Paulo

    2015-01-01

    When an organization performs an integrated analysis of risks through its Occupational Health and Safety Management System, several steps are suggested to address the implications of the identified risks. Namely, the organization should make a detailed analysis of the monetary impact for the organization of each of the preventive measures considered. However, it is also important to perform an analysis of the impact of each measure on society (externalities). The aim of this paper is to present a case study related to the application of the proposed economic evaluation methodology. An analysis of the work accidents in a hospital has been made. Three of the major types of accidents have been selected: needle stings, falls and excessive strain. Following the risk assessment, some preventive measures have been designed. Subsequently, the Benefit/Cost ratio (B/C) of these measures has been calculated, both in financial terms (from the organization's perspective) and in economic terms (including the benefits for the worker and for the Society). While the financial ratio is only advantageous in some cases, when the externalities are taken into account, the B/C ratio increases significantly. It is important to consider external benefits to make decisions concerning the implementation of preventive measures in Occupational Health and Safety projects.

  7. Evaluation of the League General Insurance Company child safety seat distribution program

    Science.gov (United States)

    1982-05-01

    This report presents an evaluation of the child safety seat distribution initiated by the League General Insurance Company in June 1979. The program provides child safety seats as a benefit under the company's auto insurance policies to policy-holder...

  8. Summary of safety evaluation toxicity studies of glufosinate ammonium.

    Science.gov (United States)

    Ebert, E; Leist, K H; Mayer, D

    1990-05-01

    This article reviews the results of toxicity studies to evaluate the safety of the herbicide glufosinate ammonium (GLA) and its formulation (200 g/litre) in laboratory animals. The data show that GLA and its formulation are slightly toxic following oral exposure. In addition, the formulation induced GLA and its formulation are slightly toxic following oral exposure. In addition, the formulation induced slight dermal toxicity and eye irritation. Testing for teratogenicity in rats and rabbits indicated no teratogenic potential, and numerous mutagenicity tests showed GLA to be non-genotoxic. Chronic toxicity testing in rats and dogs yielded no-observable-effect levels of 2 and 5 mg/kg body weight/day, respectively. Oncogenicity studies in rats and mice revealed no carcinogenic potential. On the basis of these toxicity data it is concluded that this herbicide is safe under conditions of recommended use.

  9. Safety Evaluation for Hull Waste Treatment Process in JNC

    International Nuclear Information System (INIS)

    Kojima, H.; Kurakata, K.

    2002-01-01

    Hull wastes and some scrapped equipment are typical radioactive wastes generated from reprocessing process in Tokai Reprocessing Plant (TRP). Because hulls are the wastes remained in the fuel shearing and dissolution, they contain high radioactivity. Japan Nuclear Cycle Development Institute (JNC) has started the project of Hull Waste Treatment Facility (HWTF) to treat these solid wastes using compaction and incineration methods since 1993. It is said that Zircaloy fines generated from compaction process might burn and explode intensely. Therefore explosive conditions of the fines generated in compaction process were measured. As these results, it was concluded that the fines generated from the compaction process were not hazardous material. This paper describes the outline of the treatment process of hulls and results of safety evaluation

  10. Safety evaluation of small samples for isotope production

    International Nuclear Information System (INIS)

    Sharma, Archana; Singh, Tej; Varde, P.V.

    2015-09-01

    Radioactive isotopes are widely used in basic and applied science and engineering, most notably as environmental and industrial tracers, and for medical imaging procedures. Production of radioisotope constitutes important activity of Indian nuclear program. Since its initial criticality DHRUVA reactor has been facilitating the regular supply of most of the radioisotopes required in the country for application in the fields of medicine, industry and agriculture. In-pile irradiation of the samples requires a prior estimation of the sample reactivity load, heating rate, activity developed and shielding thickness required for post irradiation handling. This report is an attempt to highlight the contributions of DHRUVA reactor, as well as to explain in detail the methodologies used in safety evaluation of the in pile irradiation samples. (author)

  11. Preliminary safety evaluation for the plutonium stabilization and packaging system

    International Nuclear Information System (INIS)

    Shapley, J.E.

    1997-01-01

    This Preliminary Safety Evaluation (PSE) describes and analyzes the installation and operation of the Plutonium Stabilization and Packaging System (SPS) at the Plutonium Finishing Plant (PFP). The SPS is a combination of components required to expedite the safe and timely storage of Plutonium (Pu) oxide. The SPS program will receive site Pu packages, process the Pu for storage, package the Pu into metallic containers, and safely store the containers in a specially modified storage vault. The location of the SPS will be in the 2736- ZB building and the storage vaults will be in the 2736-Z building of the PFP, as shown in Figure 1-1. The SPS will produce storage canisters that are larger than those currently used for Pu storage at the PFP. Therefore, the existing storage areas within the PFP secure vaults will require modification. Other modifications will be performed on the 2736-ZB building complex to facilitate the installation and operation of the SPS

  12. Safety evaluation of the radioactive waste-cement composites, (4)

    International Nuclear Information System (INIS)

    Matsuzuru, Hideo; Wadachi, Yoshiki; Ito, Akihiko

    1976-10-01

    The leaching behavior of 137 Cs has been studied to evaluate safety of sea and ground disposal of the cement composites. The rate depends on flow rate of the external solution, particle radius and composition of the cement composite. The rate-determining step of the leaching in the dynamic condition is the internal diffusion through the matrix cement composite. The rate in the static condition, on the other hand is controlled by external diffusion through the interface layer between solid and liquid. The cement composites containing mineral zeolite(25%) give very low leachability; the leaching fraction is 0.001 - 0.02 for the portland cement and 0.001 - 0.002 for the slag cement. (auth.)

  13. Evaluation and qualification of novel control techniques with safety requirements

    International Nuclear Information System (INIS)

    Gossner, S.; Wach, D.

    1985-01-01

    The paper discusses the questions related to the assessment and qualification of new I and C-systems. The tasks of nuclear power plant I and Cs as well as the efficiency of the new techniques are reflected. Problems with application of new I and Cs and the state of application in Germany and abroad are addressed. Starting from the essential differencies between conventional and new I and C-systems it is evaluated, if and in which way existing safety requirements can be met and to what extent new requirements need to be formulated. An overall concept has to be developed comprising the definition of graded requirement profiles for design and qualification. Associated qualification procedures and tools have to be adapted, developed and tuned upon each other. (orig./HP) [de

  14. The inverted cup device for blood transfer on malaria RDTs: ease of use, acceptability and safety in routine use by health workers in Nigeria.

    Science.gov (United States)

    Incardona, Sandra; Mwancha-Kwasa, Magoma; Rees-Channer, Roxanne R; Albertini, Audrey; Havumaki, Joshua; Chiodini, Peter; Oyibo, Wellington; Gonzalez, Iveth J

    2018-01-15

    Malaria rapid diagnostic tests (RDTs) are becoming widely adopted for case management at community level. However, reports and anecdotal observations indicate that the blood transfer step poses a significant challenge to many users. This study sought to evaluate the inverted cup device in the hands of health workers in everyday clinical practice, in comparison with the plastic pipette, and to determine the volume accuracy of the device made of a lower-cost plastic. The volume accuracy of inverted cup devices made of two plastics, PMMA and SBC, was compared by transferring blood 150 times onto filter paper and comparing the blood spot areas with those produced by 20 reference transfers with a calibrated micropipette. The ease of use, safety and acceptability of the inverted cup device and the pipette were evaluated by 50 health workers in Nigeria. Observations were recorded on pre-designed questionnaires, by the health workers themselves and by trained observers. Focus group discussions were also conducted. The volume accuracy assessment showed that the device made from the low-cost material (SBC) delivered a more accurate volume (mean 5.4 μL, SD 0.48 μL, range 4.5-7.0 μL) than the PMMA device (mean 5.9 μL, SD 0.48 μL, range 4.9-7.2 μL). The observational evaluation demonstrated that the inverted cup device performed better than the pipette in all aspects, e.g. higher proportions of health workers achieved successful blood collection (96%, vs. 66%), transfer of the required blood volume (90%, vs. 58%), and blood deposit without any loss (95%, vs. 50%). Majority of health workers also considered it' very easy' to use (81%),'very appropriate' for everyday use (78%), and 50% of them reported that it was their preferred BTD. The good volume accuracy and high acceptability of the inverted cup device shown in this study, along with observed ease of use and safety in hands of health workers, further strengthens prior findings which demonstrated its higher

  15. In vivo evaluation of femoral blood flow measured with magnetic resonance

    DEFF Research Database (Denmark)

    Henriksen, O; Ståhlberg, F; Thomsen, C

    1989-01-01

    , corrected for the T2 decay of non-flowing blood was used to calculate the blood flow. As a reference, the blood flow in the femoral artery was measured simultaneously with an invasive indicator dilution technique. T2 of non-flowing blood was measured in vivo in popliteal veins during regional circulatory...... arrest. The mean T2 of non-flowing blood was found to be 105 +/- 31 ms. The femoral blood flow ranged between 0 and 643 ml/min measured with MRI and between 280 and 531 ml/min measured by the indicator dilution technique. There was thus poor agreement between the two methods. The results indicate......Quantitative measurements of blood flow based on magnetic resonance imaging (MRI) using conventional multiple spin echo sequences were evaluated in vivo in healthy young volunteers. Blood flow was measured using MRI in the femoral vein. The initial slope of the multiple spin echo decay curve...

  16. Five years of simulator evaluation - a contribution to safety culture

    International Nuclear Information System (INIS)

    Engel, G.J.; Spindler, B.; Kruip, J.

    2001-01-01

    Simulator training has been an important component in education and advanced training at a high level of nuclear power plant personnel for more than 25 years. From the beginning of simulator training, checking on the objectives of learning and feedback have been part and parcel of the effort. In the course of the revision of the 1990 Directive on Expertise of Licensed Personnel in Nuclear Power Plants composed by the German Federal Ministry for the Environment (BMU), the type and organization of evaluations and the inclusion of qualified simulator trainers were expressed in even more concrete terms. Simulator evaluation serves the purpose of assessing, on the basis of the goals of practical exercises and courses established jointly with nuclear power plant operators, the performance and the behavior of individual participants so as to obtain information and guidance for further work. In addition, both simulator trainers, the Simulator Center, and the operators are to receive feedback with respect to the courses held and for checking against plans. First experience since the introduction of simulator evaluation has shown a basically positive assessment by all participants, i.e. attendees, operators, and the Simulator Center, expressing important aspects in support of training. As new simulators were commissioned in the mid-nineties, this met one of the major requests by course participants for a realistic model of their working environment. The experience accumulated also helps optimum training by means of simulators and thus ultimately also contributes to the safety culture in German nuclear technology. (orig.) [de

  17. Safety evaluation of Whole Algalin Protein (WAP) from Chlorella protothecoides.

    Science.gov (United States)

    Szabo, Nancy J; Matulka, Ray A; Chan, Teresa

    2013-09-01

    Microalgae such as Chlorella spp., were once consumed as traditional human foods; now they are being developed as ingredients for modern diets. Whole Algalin Protein (WAP) from dried milled Chlorella protothecoides was evaluated for dietary safety in a 13-week feeding trial in rodents with genotoxic potential evaluated using in vitro and in vivo assays and the likelihood of food allergy potential evaluated via human repeat-insult patch test (HRIPT). In the subchronic study, rats consumed feed containing 0, 25,000, 50,000 or 100,000 ppm WAP for 92-93 days. No treatment-related mortalities or effects in general condition, body weight, food consumption, ophthalmology, urinalysis, hematology, clinical chemistry, gross pathology, organ weights, and histopathology occurred. Several endpoints exhibited statistically significant effects, but none was dose-related. The no-observed-adverse-effect level (NOAEL) was based on the highest WAP concentration consumed by the rats and was equivalent to 4805 mg/kg/day in males and 5518 mg/kg/day in females. No mutagenicity occurred in Salmonella typhimurium or Escherichia coli tester strains (≤5000 μg/plate WAP) with or without mutagenic activation. No clastogenic response occurred in bone marrow from mice administered a single oral dose (2000 mg/kg WAP). Skin sensitization was not induced by WAP via HRIPT, indicating little potential for food allergy. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. MRI Evaluation and Safety in the Developing Brain

    Science.gov (United States)

    Tocchio, Shannon; Kline-Fath, Beth; Kanal, Emanuel; Schmithorst, Vincent J.; Panigrahy, Ashok

    2015-01-01

    Magnetic resonance imaging (MRI) evaluation of the developing brain has dramatically increased over the last decade. Faster acquisitions and the development of advanced MRI sequences such as magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), perfusion imaging, functional MR imaging (fMRI), and susceptibility weighted imaging (SWI), as well as the use of higher magnetic field strengths has made MRI an invaluable tool for detailed evaluation of the developing brain. This article will provide an overview of the use and challenges associated with 1.5T and 3T static magnetic fields for evaluation of the developing brain. This review will also summarize the advantages, clinical challenges and safety concerns specifically related to MRI in the fetus and newborn, including the implications of increased magnetic field strength, logistics related to transporting and monitoring of neonates during scanning, sedation considerations and a discussion of current technologies such as MRI-conditional neonatal incubators and dedicated small-foot print neonatal intensive care unit (NICU) scanners. PMID:25743582

  19. Nuclear criticality safety evaluation of Spray Booth Operations in X-705, Portsmouth Gaseous Diffusion Plant

    International Nuclear Information System (INIS)

    Sheaffer, M.K.; Keeton, S.C.

    1993-01-01

    This report evaluates nuclear criticality safety for Spray Booth Operations in the Decontamination and Recovery Facility, X-705, at the Portsmouth Gaseous Diffusion Plant. A general description of current procedures and related hardware/equipment is presented. Control parameters relevant to nuclear criticality safety are explained, and a consolidated listing of administrative controls and safety systems is developed. Based on compliance with DOE Orders and MMES practices, the overall operation is evaluated, and recommendations for enhanced safety are suggested

  20. Evaluation of safety climate and employee injury rates in healthcare.

    Science.gov (United States)

    Cook, Jacqueline M; Slade, Martin D; Cantley, Linda F; Sakr, Carine J

    2016-09-01

    Safety climates that support safety-related behaviour are associated with fewer work-related injuries, and prior research in industry suggests that safety knowledge and motivation are strongly related to safety performance behaviours; this relationship is not well studied in healthcare settings. We performed analyses of survey results from a Veterans Health Administration (VHA) Safety Barometer employee perception survey, conducted among VHA employees in 2012. The employee perception survey assessed 6 safety programme categories, including management participation, supervisor participation, employee participation, safety support activities, safety support climate and organisational climate. We examined the relationship between safety climate from the survey results on VHA employee injury and illness rates. Among VHA facilities in the VA New England Healthcare System, work-related injury rate was significantly and inversely related to overall employee perception of safety climate, and all 6 safety programme categories, including employee perception of employee participation, management participation, organisational climate, supervisor participation, safety support activities and safety support climate. Positive employee perceptions of safety climate in VHA facilities are associated with lower work-related injury and illness rates. Employee perception of employee participation, management participation, organisational climate, supervisor participation, safety support activities and safety support climate were all associated with lower work-related injury rates. Future implications include fostering a robust safety climate for patients and healthcare workers to reduce healthcare worker injuries. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  1. Research notes : are safety corridors really safe? Evaluation of the corridor safety improvement program.

    Science.gov (United States)

    1998-08-26

    High accident frequencies on Oregons highway corridors are of concern to the Oregon Department of Transportation (ODOT). : ODOT adopted the Corridor Safety Improvement Program as part of an overall program of safety improvements using federal and ...

  2. Safety

    International Nuclear Information System (INIS)

    1998-01-01

    A brief account of activities carried out by the Nuclear power plants Jaslovske Bohunice in 1997 is presented. These activities are reported under the headings: (1) Nuclear safety; (2) Industrial and health safety; (3) Radiation safety; and Fire protection

  3. Screening for transfusion transmissible infections using rapid diagnostic tests in Africa: a potential hazard to blood safety?

    Science.gov (United States)

    Prugger, C.; Laperche, S.; Murphy, E. L.; Bloch, E. M.; Kaidarova, Z.; Tafflet, M.; Lefrère, J.-J.; Jouven, X.

    2016-01-01

    Rapid diagnostic tests (RDTs) are routinely used in African blood centres. We analysed data from two cross-sectional studies representing 95 blood centres in 29 African countries. Standardized panels of sera containing varying concentrations of anti-human immunodeficiency virus (HIV) antibodies (Ab), hepatitis B virus antigen (HBsAg) and antihepatitis C virus (HCV) Ab were screened using routine operational testing procedures at the centres. Sensitivity of detection using RDTs was high for HIV Ab-positive samples, but low for intermediately HBsAg (51·5%) and HCV Ab (40·6%)-positive samples. These findings suggest that current RDT use in Africa could pose a hazard to blood safety. PMID:26646317

  4. Experimental Studies of quantitative evaluation using HPLC and safety of Bee Venom Acupuncture

    Directory of Open Access Journals (Sweden)

    Seong Bong Jang

    2006-02-01

    Full Text Available Objectives : This study was conducted to carry out quantitative evaluation and safety of Bee Venom Acupuncture. Methods : Content analysis was done using HPLC, measurement of , and histological observations were made on the skin and muscles. Results : 1. According to HPLC analysis, each BVA-1 contained approximately , and BVA-2 contained approximately . But the volume of coating was so minute, slight difference exists between each needle. 2. LD50 of mouse with BVA-1 was 16 counts and this is equivalent to 640 needles/kg, making Bee Venom Acupuncture safe treatment apparatus. 3. Regardless of the number of needles, there was no sign of blood stasis or inflammation detected on the skin and muscle tissues. Conclusion : Above results indicate that the Bee Venom Acupuncture can complement shortcomings of syringe usage as a part of Oriental medicine treatment, but extensive researches should be done for further verification.

  5. Safety performance evaluation of converging chevron pavement markings : final report.

    Science.gov (United States)

    2014-12-01

    The objectives of this study were (1) to perform a detailed safety analysis of converging chevron : pavement markings, quantifying the potential safety benefits and developing an understanding of the : incident types addressed by the treatment, and (...

  6. Safety Evaluation of Crocin (a constituent of saffron Tablets in Healthy Volunteers

    Directory of Open Access Journals (Sweden)

    Amir Houshang Mohamadpour

    2013-01-01

    Full Text Available Objective(s: Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects such as antioxidant, anticancer and memory improving activities. Crocin tablets were evaluated for short-term safety and tolerability in healthy adult volunteers. Materials and Methods: The study was a randomized, double-blind, placebo-controlled design consisting of one month treatment of crocin tablets. Volunteers who fulfilled inclusion and exclusion criteria were randomized into 2 groups of 22 each (males and females and received 20 mg crocin tablets or placebo. General measures of health were recorded during the study such as hematological, biochemical, hormonal and urinary parameters in pre and post-treatment periods. Results: No major adverse events were reported during the trial. Crocin tablets did not change the above parameters except that it decreased amylase, mixed white blood cells and PTT in healthy volunteers after one month. Conclusion: This clinical safety evaluation showed a relatively safe and normal profile for crocin in healthy volunteers at the given doses within the trial period.

  7. The awareness of employees in safety culture through the improved nuclear safety culture evaluation method

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Ga; Sung, Chan Ho; Jung, Yeon Sub [KHNP Central Research Institute, Daejeon (Korea, Republic of)

    2012-10-15

    After the Chernobyl nuclear accident in 1986, nuclear safety culture terminology was at first introduced emphasizing the importance of employees' attitude and organizational safety. The concept of safety culture was spread by INSAG 4 published in 1991. From that time, IAEA had provided the service of ASCOT for the safety culture assessment. However, many people still are thinking that safety culture is abstract and is not clear. It is why the systematic and reliable assessment methodology was not developed. Assessing safety culture is to identify what is the basic assumption for any organization to accept unconsciously. Therefore, it is very difficult to reach a meaningful conclusion by a superficial investigation alone. KHNP had been doing the safety culture assessment which was based on ASCOT methodology every 2 years. And this result had contributed to improving safety culture. But this result could not represent the level of organization's safety culture due to the limitation of method. So, KHNP has improved the safety culture method by benchmarking the over sea assessment techniques in 2011. The effectiveness of this improved methodology was validated through a pilot assessment. In this paper, the level of employees' safety culture awareness was analyzed by the improved method and reviewed what is necessary for the completeness and objectivity of the nuclear safety culture assessment methodology.

  8. The awareness of employees in safety culture through the improved nuclear safety culture evaluation method

    International Nuclear Information System (INIS)

    Kim, Young Ga; Sung, Chan Ho; Jung, Yeon Sub

    2012-01-01

    After the Chernobyl nuclear accident in 1986, nuclear safety culture terminology was at first introduced emphasizing the importance of employees' attitude and organizational safety. The concept of safety culture was spread by INSAG 4 published in 1991. From that time, IAEA had provided the service of ASCOT for the safety culture assessment. However, many people still are thinking that safety culture is abstract and is not clear. It is why the systematic and reliable assessment methodology was not developed. Assessing safety culture is to identify what is the basic assumption for any organization to accept unconsciously. Therefore, it is very difficult to reach a meaningful conclusion by a superficial investigation alone. KHNP had been doing the safety culture assessment which was based on ASCOT methodology every 2 years. And this result had contributed to improving safety culture. But this result could not represent the level of organization's safety culture due to the limitation of method. So, KHNP has improved the safety culture method by benchmarking the over sea assessment techniques in 2011. The effectiveness of this improved methodology was validated through a pilot assessment. In this paper, the level of employees' safety culture awareness was analyzed by the improved method and reviewed what is necessary for the completeness and objectivity of the nuclear safety culture assessment methodology

  9. Safety assessment for a KBS-3H spent nuclear fuel repository at Olkiluoto. Complementary evaluations of safety

    International Nuclear Information System (INIS)

    Neall, Fiona; Pastina, Barbara; Snellman, Margit; Smith, Paul; Gribi, P.; Johnson, Lawrence

    2008-12-01

    The KBS-3H design is a variant of the more general KBS-3 method for the geological disposal of spent nuclear fuel in Finland and Sweden. In the KBS-3H design, multiple assemblies containing spent fuel are emplaced horizontally in parallel, approximately 300 m long, slightly inclined deposition drifts. The copper canisters, each with a surrounding layer of bentonite clay, are placed in perforated steel shells prior to deposition in the drifts; the assembly is called the 'supercontainer'. The other KBS-3 variant is the KBS-3V design, in which the copper canisters are emplaced vertically in individual deposition holes surrounded by bentonite clay but without steel supercontainer shells. SKB and Posiva have conducted a Research, Development and Demonstration programme over the period 2002-2007 with the overall aim of establishing whether KBS-3H represents a feasible alternative to KBS-3V. As part of this programme, the long-term safety of a KBS-3H repository has been assessed in the KBS-3H safety studies. In order to focus the safety studies, the Olkiluoto site in the municipality of Eurajoki, which is the proposed site for a spent fuel repository in Finland, was used as a hypothetical site for a KBS-3H repository. The present report is part of a portfolio of reports discussing the long-term safety of the KBS-3H repository. The overall outcome of the KBS-3H safety studies is documented in the summary report, 'Safety assessment for a KBS-3H repository for spent nuclear fuel at Olkiluoto'. The purpose and scope of the KBS-3H complementary evaluations of safety report is provided in Posiva's Safety Case Plan, which is based on Regulatory Guide YVL 8.4 and on international guidelines on complementary lines of argument to long-term safety that are considered an important element of a post-closure safety case for geological repositories. Complementary evaluations of safety require the use of evaluations, evidence and qualitative supporting arguments that lie outside the

  10. Safety assessment for a KBS-3H spent nuclear fuel repository at Olkiluoto. Complementary evaluations of safety

    Energy Technology Data Exchange (ETDEWEB)

    Neall, Fiona; Pastina, Barbara; Snellman, Margit; Smith, Paul; Gribi, P.; Johnson, Lawrence

    2008-12-15

    The KBS-3H design is a variant of the more general KBS-3 method for the geological disposal of spent nuclear fuel in Finland and Sweden. In the KBS-3H design, multiple assemblies containing spent fuel are emplaced horizontally in parallel, approximately 300 m long, slightly inclined deposition drifts. The copper canisters, each with a surrounding layer of bentonite clay, are placed in perforated steel shells prior to deposition in the drifts; the assembly is called the 'supercontainer'. The other KBS-3 variant is the KBS-3V design, in which the copper canisters are emplaced vertically in individual deposition holes surrounded by bentonite clay but without steel supercontainer shells. SKB and Posiva have conducted a Research, Development and Demonstration programme over the period 2002-2007 with the overall aim of establishing whether KBS-3H represents a feasible alternative to KBS-3V. As part of this programme, the long-term safety of a KBS-3H repository has been assessed in the KBS-3H safety studies. In order to focus the safety studies, the Olkiluoto site in the municipality of Eurajoki, which is the proposed site for a spent fuel repository in Finland, was used as a hypothetical site for a KBS-3H repository. The present report is part of a portfolio of reports discussing the long-term safety of the KBS-3H repository. The overall outcome of the KBS-3H safety studies is documented in the summary report, 'Safety assessment for a KBS-3H repository for spent nuclear fuel at Olkiluoto'. The purpose and scope of the KBS-3H complementary evaluations of safety report is provided in Posiva's Safety Case Plan, which is based on Regulatory Guide YVL 8.4 and on international guidelines on complementary lines of argument to long-term safety that are considered an important element of a post-closure safety case for geological repositories. Complementary evaluations of safety require the use of evaluations, evidence and qualitative supporting arguments

  11. Evaluation of safety practices and performance in a brewery industry ...

    African Journals Online (AJOL)

    Michael Horsfall

    prevented in the period of the safety programme which translates to an average of 19.45 per year. The safety programme ... due to “weak safeguards against occupational and .... outputs within such a system. In this ..... Journal of Disaster Prevention and Management: ... Duignan, T. (2003), “Good health and safety is good.

  12. Blood

    Science.gov (United States)

    ... a reduced production of red blood cells, including: Iron deficiency anemia. Iron deficiency anemia is the most common type of anemia and ... inflammatory bowel disease are especially likely to have iron deficiency anemia. Anemia due to chronic disease. People with chronic ...

  13. Evaluation Of Blood Collected From Clinically Diagnosed Typhoid ...

    African Journals Online (AJOL)

    Blood culture revealed that 216 (42.8%) bacterial pathogens were isolated from the Widal positive patients yielded out of which 101 (46.8%) isolates were of ... fatal illness such as malaria and other parasitaemia, non-typhoid salmonellosis, endocarditis and other gastro-intestinal infections may have been responsible.

  14. Evaluation of the Blood-Glucose Reducing Effects of Aqueous ...

    African Journals Online (AJOL)

    Methods: All the aqueous extracts of (Caraway) CA, (Coriander) CO, (Cumin) CU, (Dill) DI and (Fennel) FE were administered at dose levels of 300 mg/kg body weight orally to different groups each containing 5 animals. A control group was also maintained simultaneously and received distilled water orally.Blood samples ...

  15. Critical Evaluation of Blood Volume Measurements during Hemodialysis

    NARCIS (Netherlands)

    Dasselaar, Judith J.; van der Sande, Frank M.; Franssen, Casper F. M.

    2012-01-01

    Devices that continuously measure relative blood volume (RBV) changes during hemodialysis (HD) are increasingly used for the prevention of dialysis hypotension and fine-tuning of dry weight. However, RBV measurements are subject to various limitations. First, RBV devices provide information on

  16. Does lean management improve patient safety culture? An extensive evaluation of safety culture in a radiotherapy institute.

    Science.gov (United States)

    Simons, Pascale A M; Houben, Ruud; Vlayen, Annemie; Hellings, Johan; Pijls-Johannesma, Madelon; Marneffe, Wim; Vandijck, Dominique

    2015-02-01

    The importance of a safety culture to maximize safety is no longer questioned. However, achieving sustainable culture improvements are less evident. Evidence is growing for a multifaceted approach, where multiple safety interventions are combined. Lean management is such an integral approach to improve safety, quality and efficiency and therefore, could be expected to improve the safety culture. This paper presents the effects of lean management activities on the patient safety culture in a radiotherapy institute. Patient safety culture was evaluated over a three year period using triangulation of methodologies. Two surveys were distributed three times, workshops were performed twice, data from an incident reporting system (IRS) was monitored and results were explored using structured interviews with professionals. Averages, chi-square, logistical and multi-level regression were used for analysis. The workshops showed no changes in safety culture, whereas the surveys showed improvements on six out of twelve dimensions of safety climate. The intention to report incidents not reaching patient-level decreased in accordance with the decreasing number of reports in the IRS. However, the intention to take action in order to prevent future incidents improved (factorial survey presented β: 1.19 with p: 0.01). Due to increased problem solving and improvements in equipment, the number of incidents decreased. Although the intention to report incidents not reaching patient-level decreased, employees experienced sustained safety awareness and an increased intention to structurally improve. The patient safety culture improved due to the lean activities combined with an organizational restructure, and actual patient safety outcomes might have improved as well. Copyright © 2014 Elsevier Ltd. All rights reserved.

  17. PGSFR Core Thermal Design Procedure to Evaluate the Safety Margin

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Sun Rock; Kim, Sang-Ji [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2014-10-15

    The Korea Atomic Energy Research Institute (KAERI) has performed a SFR design with the final goal of constructing a prototype plant by 2028. The main objective of the SFR prototype plant is to verify the TRU metal fuel performance, reactor operation, and transmutation ability of high-level wastes. The core thermal design is to ensure the safe fuel performance during the whole plant operation. Compared to the critical heat flux in typical light water reactors, nuclear fuel damage in SFR subassemblies arises from a creep induced failure. The creep limit is evaluated based on the maximum cladding temperature, power, neutron flux, and uncertainties in the design parameters, as shown in Fig. 1. In this work, the core thermal design procedures are compared to verify the present PGSFR methodology based on the nuclear plant design criteria/guidelines and previous SFR thermal design methods. The PGSFR core thermal design procedure is verified based on the nuclear plant design criteria/guidelines and previous methods in LWRs and SFRs. The present method aims to directly evaluate the fuel cladding failure and to assure more safety margin. The 2 uncertainty is similar to 95% one-side tolerance limit of 1.96 in LWRs. The HCFs, ITDP, and MCM reveal similar uncertainty propagation for cladding midwall temperature for typical SFR conditions. The present HCFs are mainly employed from the CRBR except the fuel-related uncertainty such as an incorrect fuel distribution. Preliminary PGSFR specific HCFs will be developed by the end of 2015.

  18. Safety evaluation of filamentous fungi isolated from industrial doenjang koji.

    Science.gov (United States)

    Lee, Jin Hee; Jo, Eun Hye; Hong, Eun Jin; Kim, Kyung Min; Lee, Inhyung

    2014-10-01

    A few starters have been developed and used for doenjang fermentation but often without safety evaluation. Filamentous fungi were isolated from industrial doenjang koji, and their potential for mycotoxin production was evaluated. Two fungi were isolated; one was more dominantly present (90%). Both greenish (SNU-G) and whitish (SNU-W) fungi showed 97% and 95% internal transcribed spacer sequence identities to Aspergillus oryzae/flavus, respectively. However, the SmaI digestion pattern of their genomic DNA suggested that both belong to A. oryzae. Moreover, both fungi had morphological characteristics similar to that of A. oryzae. SNU-G and SNU-W did not form sclerotia, which is a typical characteristic of A. oryzae. Therefore, both fungi were identified to be A. oryzae. In aflatoxin gene cluster analysis, both fungi had norB-cypA genes similar to that of A. oryzae. Consistent with this, aflatoxins were not detected in SNU-G and SNU-W using ammonia vapor, TLC, and HPLC analyses. Both fungi seemed to have a whole cyclopiazonic acid (CPA) gene cluster based on PCR of the maoA, dmaT, and pks-nrps genes, which are key genes for CPA biosynthesis. However, CPA was not detected in TLC and HPLC analyses. Therefore, both fungi seem to be safe to use as doenjang koji starters and may be suitable fungal candidates for further development of starters for traditional doenjang fermentation.

  19. Safety Evaluation of Cosmetic Ingredients Regarding Their Skin Sensitization Potential

    Directory of Open Access Journals (Sweden)

    Winfried Steiling

    2016-03-01

    Full Text Available Up to today, product safety evaluation in the EU is predominantly based on data/information on their individual ingredients. Consequently, the quality and reliability of individual ingredient data is of vital interest. In this context, the knowledge about skin sensitization potential is an explicit need for both hazard and risk assessment. Proper skin sensitization data of the individual chemicals is essential, especially when dermal contact is intended, like for cosmetics. In some cases, e.g., in the presence of irritating chemicals, the combination of individual ingredients may also need to be evaluated to cover possible mixture effects. Today, it seems unlikely or even impossible that skin sensitization in humans can be adequately described by a single test result or even by a simple combination of a few data points (in vivo or in vitro. It is becoming evident that a set of data (including human data and market data and knowledge about the ingredient’s specific sensitizing potency needs to be taken into account to enable a reliable assessment of skin sensitization. A more in-depth understanding on mechanistic details of the Adverse-Outcome-Pathway of skin sensitization could contribute key data for a robust conclusion on skin sensitization.

  20. [Safety evaluation and risk control measures of Cassiae Semen].

    Science.gov (United States)

    Zhao, Yi-Meng; Wu, Li; Zhang, Shuo; Zhang, Li; Gao, Xue-Min; Sun, Xiao-Bo; Wang, Chun

    2017-11-01

    In this study, the authors reviewed domestic and foreign literatures, conducted the textual research on origin and development of Cassia Semen, studied records in ancient books and ancient and modern literatures, clinical adverse reactions and relevant experimental studies in recent years, and summarized the clinical features and influencing factors related to the safety of Cassiae Semen. According to the findings,Cassia Semen's safety risks are mainly liver and kidney system damages, with the main clinical features of fatigue, anorexia, disgusting of oil, yellow urine and gray stool; digestive system injury, with the main clinical features of diarrhea, abdominal distension, nausea and loose stool; reproductive system damage, with the main clinical features of vaginal bleeding. Allergic reactions and clinical adverse events, with the main clinical features for numb mouth, itching skin, nausea and vomiting, diarrhea, wheezing and lip cyanosis were also reported. The toxicological studies on toxic components of Cassiae Semen obtusifolia were carried out through acute toxicity test, subacute toxicity test, subchronic toxicity test and chronic toxicity test. Risk factors might include patients, compatibility and physicians. Physicians should strictly abide by the medication requirements in the Pharmacopoeia, pay attention to rational compatibility, appropriate dosage,correct usage and appropriate processing, control the dosage below 15 g to avoid excessive intake, strictly control the course of treatment to avoid accumulated poisoning caused by long-term administration. At the same time, clinicians should pay attention to the latest research progress, update the knowledge structure, quickly find the latest and useful materials from clinical practice, scientific research and drug information and other literatures, make evaluation and judgment for the materials, establish a traditional Chinese medicine intelligence information library, and strengthen the control over

  1. Strengthening of the nuclear safety regulatory body. Field evaluation review

    International Nuclear Information System (INIS)

    1996-10-01

    As a result of a request from the Preparation Committee of the Nuclear Regulatory Authority (NRA) in 1992, and as recommended by the CEC/RAMG (Commission of European Communities/Regulatory Assistance Management Group) and the Agency mission in July 1993 to the Slovak Republic, the project SLR/9/005 was approved in 1993 as a model project for the period 1994-1996. Current budge is $401,340 and disbursements to date amount to $312,873. The project time schedule has been extended to 1997. The major conclusions of this evaluation are as follows: The project responded to an urgent national need, as well as to a statutory mandate of the Agency, and was adequately co-ordinated with other international assistance programmes to NRA. The project was designed as a structured programme of assistance by means of expert missions, scientific visits and a limited amount of equipment, acting upon several key areas of NRA regulatory responsibilities. Agency assistance was provided in a timely manner. A high concentration of expert missions was noticed at the initial stages of the project, which posed some managements problems. This was corrected to some extent in the course of implementation. Additionally, some overlapping of expert mission recommendations suggests that improvements are needed in the design of such missions. The exposure to international regulatory practice and expertise has resulted in substantial developments of NRA, both in organizational and operational terms. The project can claim to have contributed to NRA having gained governmental and international confidence. NRA's role in the safety assessment of Bohunice V1 reconstruction, as well as in Bohunice V2 safety review, Bohunice A1 decommissioning and in informing the public, also points at the success achieved by the project. The institutional and financial support of the Government contributed decisively to the project achievements. (author). Figs, tabs

  2. 18F-FDG-labeled red blood cell PET for blood-pool imaging: preclinical evaluation in rats.

    Science.gov (United States)

    Matsusaka, Yohji; Nakahara, Tadaki; Takahashi, Kazuhiro; Iwabuchi, Yu; Nishime, Chiyoko; Kajimura, Mayumi; Jinzaki, Masahiro

    2017-12-01

    Red blood cells (RBCs) labeled with single-photon emitters have been clinically used for blood-pool imaging. Although some PET tracers have been introduced for blood-pool imaging, they have not yet been widely used. The present study investigated the feasibility of labeling RBCs with 18 F-2-deoxy-2-fluoro-D-glucose ( 18 F-FDG) for blood-pool imaging with PET. RBCs isolated from venous blood of rats were washed with glucose-free phosphate-buffered saline and labeled with 18 F-FDG. To optimize labeling efficiency, the effects of glucose deprivation time and incubation (labeling) time with 18 F-FDG were investigated. Post-labeling stability was assessed by calculating the release fraction of radioactivity and identifying the chemical forms of 18 F in the released and intracellular components of 18 F-FDG-labeled RBCs incubated in plasma. Just after intravenous injection of the optimized autologous 18 F-FDG-labeled RBCs, dynamic PET scans were performed to evaluate in vivo imaging in normal rats and intraabdominal bleeding models (temporary and persistent bleeding). The optimal durations of glucose deprivation and incubation (labeling) with 18 F-FDG were 60 and 30 min, respectively. As low as 10% of 18 F was released as the form of 18 F-FDG from 18 F-FDG-labeled RBCs after a 60-min incubation. Dynamic PET images of normal rats showed strong persistence in the cardiovascular system for at least 120 min. In the intraabdominal bleeding models, 18 F-FDG-labeled RBC PET visualized the extravascular blood clearly and revealed the dynamic changes of the extravascular radioactivity in the temporary and persistent bleeding. RBCs can be effectively labeled with 18 F-FDG and used for blood-pool imaging with PET in rats.

  3. Evaluation of Amount of Blood in Dry Blood Spots: Ring-Disk Electrode Conductometry.

    Science.gov (United States)

    Kadjo, Akinde F; Stamos, Brian N; Shelor, C Phillip; Berg, Jordan M; Blount, Benjamin C; Dasgupta, Purnendu K

    2016-06-21

    A fixed area punch in dried blood spot (DBS) analysis is assumed to contain a fixed amount of blood, but the amount actually depends on a number of factors. The presently preferred approach is to normalize the measurement with respect to the sodium level, measured by atomic spectrometry. Instead of sodium levels, we propose electrical conductivity of the extract as an equivalent nondestructive measure. A dip-type small diameter ring-disk electrode (RDE) is ideal for very small volumes. However, the conductance (G) measured by an RDE depends on the depth (D) of the liquid below the probe. There is no established way of computing the specific conductance (σ) of the solution from G. Using a COMSOL Multiphysics model, we were able to obtain excellent agreement between the measured and the model predicted conductance as a function of D. Using simulations over a large range of dimensions, we provide a spreadsheet-based calculator where the RDE dimensions are the input parameters and the procedure determines the 99% of the infinite depth conductance (G99) and the depth D99 at which this is reached. For typical small diameter probes (outer electrode diameter ∼ <2 mm), D99 is small enough for dip-type measurements in extract volumes of ∼100 μL. We demonstrate the use of such probes with DBS extracts. In a small group of 12 volunteers (age 20-66), the specific conductance of 100 μL aqueous extracts of 2 μL of spotted blood showed a variance of 17.9%. For a given subject, methanol extracts of DBS spots nominally containing 8 and 4 μL of blood differed by a factor of 1.8-1.9 in the chromatographically determined values of sulfate and chloride (a minor and major constituent, respectively). The values normalized with respect to the conductance of the extracts differed by ∼1%. For serum associated analytes, normalization of the analyte value by the extract conductance can thus greatly reduce errors from variations in the spotted blood volume/unit area.

  4. MR measurement of coronary arterial blood flow velocity. Evaluation of age, stenosis and drugs as factors affecting coronary blood flow

    International Nuclear Information System (INIS)

    Taoka, Yoshiaki; Harada, Masafumi; Nishitani, Hiromu; Yukinaka, Michiko; Nomura, Masahiro

    1998-01-01

    Coronary arterial blood flow velocity was measured using MRI. Two types of phase contrast methods were used for the measurements, one of which exhibited good resolving power whereas the other provided more distinct images acquired while the subject patients held their breath. Before measuring coronary arterial blood flow velocity, accuracy of the two phase contrast methods was evaluated using a phantom. The results obtained with both methods largely agreed with the values obtained using the phantom. Using both methods, the patterns of coronary arterial blood flow over one cardiac cycle were essentially identical. A peak was noted in late systole or in early diastole in the right coronary artery, whereas in the left coronary artery, a peak was noted somewhat later in diastole. In healthy volunteers, no significant difference in the maximal flow velocity in the coronary arteries was found from one age group to another. Among patients with coronary arterial stenosis, coronary arterial blood flow velocity central to the area of stenosis was lower than that observed in the healthy volunteers. Coronary arterial blood flow velocity was observed to decrease after administration of isosorbide dinitrate and increased following administration of nifedipine. (author)

  5. Consumer and farmer safety evaluation of application of botanical pesticides in black pepper crop protection

    NARCIS (Netherlands)

    Hernandez-Moreno, J.; Soffers, A.E.M.F.; Wiratno,; Falke, H.E.; Rietjens, I.; Murk, A.J.

    2013-01-01

    This study presents a consumer and farmer safety evaluation on the use of four botanical pesticides in pepper berry crop protection. The pesticides evaluated include preparations from clove, tuba root, sweet flag and pyrethrum. Their safety evaluation was based on their active ingredients being

  6. High-speed video capillaroscopy method for imaging and evaluation of moving red blood cells

    Science.gov (United States)

    Gurov, Igor; Volkov, Mikhail; Margaryants, Nikita; Pimenov, Aleksei; Potemkin, Andrey

    2018-05-01

    The video capillaroscopy system with high image recording rate to resolve moving red blood cells with velocity up to 5 mm/s into a capillary is considered. Proposed procedures of the recorded video sequence processing allow evaluating spatial capillary area, capillary diameter and central line with high accuracy and reliability independently on properties of individual capillary. Two-dimensional inter frame procedure is applied to find lateral shift of neighbor images in the blood flow area with moving red blood cells and to measure directly the blood flow velocity along a capillary central line. The developed method opens new opportunities for biomedical diagnostics, particularly, due to long-time continuous monitoring of red blood cells velocity into capillary. Spatio-temporal representation of capillary blood flow is considered. Experimental results of direct measurement of blood flow velocity into separate capillary as well as capillary net are presented and discussed.

  7. Catheter-Based Measurements of Absolute Coronary Blood Flow and Microvascular Resistance: Feasibility, Safety, and Reproducibility in Humans.

    Science.gov (United States)

    Xaplanteris, Panagiotis; Fournier, Stephane; Keulards, Daniëlle C J; Adjedj, Julien; Ciccarelli, Giovanni; Milkas, Anastasios; Pellicano, Mariano; Van't Veer, Marcel; Barbato, Emanuele; Pijls, Nico H J; De Bruyne, Bernard

    2018-03-01

    The principle of continuous thermodilution can be used to calculate absolute coronary blood flow and microvascular resistance (R). The aim of the study is to explore the safety, feasibility, and reproducibility of coronary blood flow and R measurements as measured by continuous thermodilution in humans. Absolute coronary flow and R can be calculated by thermodilution by infusing saline at room temperature through a dedicated monorail catheter. The temperature of saline as it enters the vessel, the temperature of blood and saline mixed in the distal part of the vessel, and the distal coronary pressure were measured by a pressure/temperature sensor-tipped guidewire. The feasibility and safety of the method were tested in 135 patients who were referred for coronary angiography. No significant adverse events were observed; in 11 (8.1%) patients, bradycardia and concomitant atrioventricular block appeared transiently and were reversed immediately on interruption of the infusion. The reproducibility of measurements was tested in a subgroup of 80 patients (129 arteries). Duplicate measurements had a strong correlation both for coronary blood flow (ρ=0.841, P <0.001; intraclass correlation coefficient=0.89, P <0.001) and R (ρ=0.780, P <0.001; intraclass correlation coefficient=0.89, P <0.001). In Bland-Altman plots, there was no significant bias or asymmetry. Absolute coronary blood flow (in L/min) and R (in mm Hg/L/min or Wood units) can be safely and reproducibly measured with continuous thermodilution. This approach constitutes a new opportunity for the study of the coronary microcirculation. © 2018 American Heart Association, Inc.

  8. Evaluation of low dose ionizing radiation effect on some blood components in animal model

    OpenAIRE

    El-Shanshoury, H.; El-Shanshoury, G.; Abaza, A.

    2016-01-01

    Exposure to ionizing radiation is known to have lethal effects in blood cells. It is predicted that an individual may spend days, weeks or even months in a radiation field without becoming alarmed. The study aimed to discuss the evaluation of low dose ionizing radiation (IR) effect on some blood components in animal model. Hematological parameters were determined for 110 animal rats (divided into 8 groups) pre- and post-irradiation. An attempt to explain the blood changes resulting from both ...

  9. Preliminary safety evaluation for the spent nuclear fuel project`s cold vacuum drying system

    Energy Technology Data Exchange (ETDEWEB)

    Garvin, L.J., Westinghouse Hanford

    1996-07-01

    This preliminary safety evaluation (PSE) considers only the Cold Vacuum Drying System (CVDS) facility and its mission as it relates to the integrated process strategy (WHC 1995). The purpose of the PSE is to identify those CBDS design functions that may require safety- class and safety-significant accident prevention and mitigation features.

  10. Development and application of an integrated evaluation framework for preventive safety applications

    NARCIS (Netherlands)

    Scholliers, J.; Joshi, S.; Gemou, M.; Hendriks, F.; Ljung Aust, M.; Luoma, J.; Netto, M.; Engstrom, J.; Leanderson Olsson, S.; Kutzner, R.; Tango, F.; Amditis, A.J.; Blosseville, J.M.; Bekiaris, E.

    2011-01-01

    Preventive safety functions help drivers avoid or mitigate accidents. No quantitative methods have been available to evaluate the safety impact of these systems. This paper describes a framework for the assessment of preventive and active safety functions, which integrates procedures for technical

  11. Evaluation of efficacy and safety of Reteplase and Alteplase in the treatment of hyper-acute cerebral infarction.

    Science.gov (United States)

    Lin, Zhi-Jian; Qiu, Hong-Yan; Tong, Xiao-Xin; Guo, Yi; Han, Man-Fu; Yang, Chun-Shui; Lin, Kai-Hua; Wu, Jun; Li, Xing; Yang, Yang

    2018-02-28

    Objective: The present study aimed to investigate the efficacy and safety of Reteplase (rPA) and Alteplase (rt-PA) in the treatment of hyper-acute cerebral infarction (CI). Methods: Six hundred and eleven patients with hyper-acute CI selected from September 2014 to September 2016 were assigned into the aspirin, rt-PA, rPA, rt-PA + aspirin, and rPA + aspirin groups based on their willingness. The difference of efficacy in five groups were evaluated with National Institute of Health Stroke Scale (NIHSS), modified rankin scale (mRS), and Barthel Index (BI). Coagulation function, blood lipid, and hemodynamics were analyzed. The safety differences were compared by observing the adverse reactions. Results: Compared with the rt-PA, rPA, and aspirin groups, NIHSS score, mRS score, the incidence of non- and symptomatic cerebral hemorrhage as well as the rate of adverse reactions were decreased, while BI were increased in the rt-PA + aspirin and rPA + aspirin groups after treatment. Compared with the rt-PA and rPA groups, total cholesterol (TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were lower, whereas the hematocrit, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity, erythrocyte electrophoresis time, fibrinogen, erythrocyte sedimentation rate (ESR), K value in blood sedimentation equation, and the comprehensive abnormality degree of blood rheology were higher in the rt-PA + aspirin and rPA + aspirin groups. Conclusion: The efficacy and safety of rt-PA or rPA combined with aspirin in the treatment of hyper-acute CI were better than those of rPA or rt-PA monotherapy. © 2018 The Author(s).

  12. Safety evaluation by living probabilistic safety assessment. Procedures and applications for planning of operational activities and analysis of operating experience

    International Nuclear Information System (INIS)

    Johanson, Gunnar; Holmberg, J.

    1994-01-01

    Living Probabilistic Safety Assessment (PSA) is a daily safety management system and it is based on a plant-specific PSA and supporting information systems. In the living use of PSA, plant status knowledge is used to represent actual plant safety status in monitoring or follow-up perspective. The PSA model must be able to express the risk at a given time and plant configuration. The process, to update the PSA model to represent the current or planned configuration and to use the model to evaluate and direct the changes in the configuration, is called living PSA programme. The main purposes to develop and increase the usefulness of living PSA are: Long term safety planning: To continue the risk assessment process started with the basic PSA by extending and improving the basic models and data to provide a general risk evaluation tool for analyzing the safety effects of changes in plant design and procedures. Risk planning of operational activities: To support the operational management by providing means for searching optimal operational maintenance and testing strategies from the safety point of view. The results provide support for risk decision making in the short term or in a planning mode. The operational limits and conditions given by technical specifications can be analyzed by evaluating the risk effects of alternative requirements in order to balance the requirements with respect to operational flexibility and plant economy. Risk analysis of operating experience: To provide a general risk evaluation tool for analyzing the safety effects of incidents and plant status changes. The analyses are used to: identify possible high risk situations, rank the occurred events from safety point of view, and get feedback from operational events for the identification of risk contributors. This report describes the methods, models and applications required to continue the process towards a living use of PSA. 19 tabs, 20 figs

  13. Development of safety factors to be used for evaluation of cracked nuclear components

    International Nuclear Information System (INIS)

    Brickstad, B.; Bergman, M.

    1996-10-01

    A modified concept for safety evaluation is introduced which separately accounts for the failure mechanisms fracture and plastic collapse. For application on nuclear components a set of safety factors are also proposed that retain the safety margins expressed in ASME, section III and XI. By performing comparative studies of the acceptance levels for surface cracks in pipes and a pressure vessel, it is shown that some of the anomalies connected with the old safety procedures are removed. It is the authors belief that the outlined safety evaluation procedure has the capability of treating cracks in a consistent way and that the procedure together with the proposed safety factors fulfill the basic safety requirements for nuclear components. Hopefully, it is possible in the near future to develop a probabilistic safety assessment procedure in Sweden, which enables a systematic treatment of uncertainties in the involved data. 14 refs

  14. Safety evaluation of the nuclear power plant at Cattenom

    International Nuclear Information System (INIS)

    Anon.

    1987-01-01

    This is a systematic compilation of the material which was dealt with at the level of the German-French Commission (on questions of the safety of nuclear installations) in this discussions about the nuclear power plant at Cattenom. As a supplement to the report published already in 1982, the Commission has officially released its deliberation results on the subjects constructive safety measures, radiological effects, and precautions in case of an emergency. The allegations according to which the installation is wanting in safety are countered by the joint statement of the chairmen of GPR (Permanent Group on Reactors) and RSK (German Commission on Reactor Safety) of August 29, 1986. (HSCH) [de

  15. Development of the evaluation methods in reactor safety analyses and core characteristics

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    In order to support the safety reviews by NRA on reactor safety design including the phenomena with multiple failures, the computer codes are developed and the safety evaluations with analyses are performed in the areas of thermal hydraulics and core characteristics evaluation. In the code preparation of safety analyses, the TRACE and RELAP5 code were prepared to conduct the safety analyses of LOCA and beyond design basis accidents with multiple failures. In the core physics code preparation, the functions of sensitivity and uncertainty analysis were incorporated in the lattice physics code CASMO-4. The verification of improved CASMO-4 /SIMULATE-3 was continued by using core physics data. (author)

  16. Preload-based Starling-like control of rotary blood pumps: An in-vitro evaluation.

    Directory of Open Access Journals (Sweden)

    Mahdi Mansouri

    Full Text Available Due to a shortage of donor hearts, rotary left ventricular assist devices (LVADs are used to provide mechanical circulatory support. To address the preload insensitivity of the constant speed controller (CSC used in conventional LVADs, we developed a preload-based Starling-like controller (SLC. The SLC emulates the Starling law of the heart to maintain mean pump flow ([Formula: see text] with respect to mean left ventricular end diastolic pressure (PLVEDm as the feedback signal. The SLC and CSC were compared using a mock circulation loop to assess their capacity to increase cardiac output during mild exercise while avoiding ventricular suction (marked by a negative PLVEDm and maintaining circulatory stability during blood loss and severe reductions in left ventricular contractility (LVC. The root mean squared hemodynamic deviation (RMSHD metric was used to assess the clinical acceptability of each controller based on pre-defined hemodynamic limits. We also compared the in-silico results from our previously published paper with our in-vitro outcomes. In the exercise simulation, the SLC increased [Formula: see text] by 37%, compared to only 17% with the CSC. During blood loss, the SLC maintained a better safety margin against left ventricular suction with PLVEDm of 2.7 mmHg compared to -0.1 mmHg for CSC. A transition to reduced LVC resulted in decreased mean arterial pressure (MAP and [Formula: see text] with CSC, whilst the SLC maintained MAP and [Formula: see text]. The results were associated with a much lower RMSHD value with SLC (70.3% compared to CSC (225.5%, demonstrating improved capacity of the SLC to compensate for the varying cardiac demand during profound circulatory changes. In-vitro and in-silico results demonstrated similar trends to the simulated changes in patient state however the magnitude of hemodynamic changes were different, thus justifying the progression to in-vitro evaluation.

  17. Evaluation of the efficacy and safety of endovascular management for transplant renal artery stenosis

    Directory of Open Access Journals (Sweden)

    Leonardo G.M. Valle

    Full Text Available OBJECTIVES: To evaluate the safety and efficacy of endovascular intervention with angioplasty and stent placement in patients with transplant renal artery stenosis. METHODS: All patients diagnosed with transplant renal artery stenosis and graft dysfunction or resistant systemic hypertension who underwent endovascular treatment with stenting from February 2011 to April 2016 were included in this study. The primary endpoint was clinical success, and the secondary endpoints were technical success, complication rate and stent patency. RESULTS: Twenty-four patients with transplant renal artery stenosis underwent endovascular treatment, and three of them required reinterventions, resulting in a total of 27 procedures. The clinical success rate was 100%. All graft dysfunction patients showed decreased serum creatinine levels and improved estimated glomerular filtration rates and creatinine levels. Patients with high blood pressure also showed improved control of systemic blood pressure and decreased use of antihypertensive drugs. The technical success rate of the procedure was 97%. Primary patency and assisted primary patency rates at one year were 90.5% and 100%, respectively. The mean follow-up time of patients was 794.04 days after angioplasty. CONCLUSION: Angioplasty with stent placement for the treatment of transplant renal artery stenosis is a safe and effective technique with good results in both the short and long term.

  18. Safety evaluation on MOX new fuel at marine transport

    International Nuclear Information System (INIS)

    Tsumune, Daisuke; Ito, Chihiro; Saegusa, Toshiari; Maruyama, Koki

    2000-01-01

    In the Central Research Institute of Electric Power Industry, in order to confirm effects of MOX new fuel on the public are as small as possible even when its marine transport goes down, some exposed radiation dose has previously conducted on imaginary shipwreck of marine transport on used nuclear fuel, plutonium dioxide, and high level return glass solid. Under a base of such informations, some investigations on safety on marine transport of the MOX new fuel was conducted. On September, 1999, five transport vessels of the MOX new fuel was at first transported on marine. The value of five times of estimated exposed radiation dose (max. 8.1 x 10 -8 mSv/y) corresponds to an evaluation result assumed by shipwreck in marine transport this time. As a result, it was found that the exposed radiation dose estimated on this case would be sufficiently less than an effective dose equivalent limit (1 mSv/y) of public exposure according to the recommendation of ICRP in both coastal and oceanic areas. (G.K.)

  19. Modelling operator cognitive interactions in nuclear power plant safety evaluation

    International Nuclear Information System (INIS)

    Senders, J.W.; Moray, N.; Smiley, A.; Sellen, A.

    1985-08-01

    The overall objectives of the study were to review methods which are applicable to the analysis of control room operator cognitive interactions in nuclear plant safety evaluations and to indicate where future research effort in this area should be directed. This report is based on an exhaustive search and review of the literature on NPP (Nuclear Power Plant) operator error, human error, human cognitive function, and on human performance. A number of methods which have been proposed for the estimation of data for probabilistic risk analysis have been examined and have been found wanting. None addresses the problem of diagnosis error per se. Virtually all are concerned with the more easily detected and identified errors of action. None addresses underlying cause and mechanism. It is these mechanisms which must be understood if diagnosis errors and other cognitive errors are to be controlled and predicted. We have attempted to overcome the deficiencies of earlier work and have constructed a model/taxonomy, EXHUME, which we consider to be exhaustive. This construct has proved to be fruitful in organizing our thinking about the kinds of error that can occur and the nature of self-correcting mechanisms, and has guided our thinking in suggesting a research program which can provide the data needed for quantification of cognitive error rates and of the effects of mitigating efforts. In addition a preliminary outline of EMBED, a causal model of error, is given based on general behavioural research into perception, attention, memory, and decision making. 184 refs

  20. Process Inherent Ultimate Safety (PIUS) reactor evaluation study: Final report

    International Nuclear Information System (INIS)

    1987-02-01

    This report presents the results of an independent study by United Engineers and Constructors (UNITED) of the SECURE-P Process Inherent Ultimate Safety (PIUS) Reactor Concept which is presently under development by the Swedish light water reactor vendor ASEA-ATOM of Vasteras, Sweden. This study was performed to investigate whether there is any realistic basis for believing that the PIUS reactor could be a viable competitor in the US energy market in the future. Assessments were limited to the technical, economic and licensing aspects of PIUS. Socio-political issues, while certainly important in answering this question, are so broad and elusive that it was considered that addressing them with the limited perspective of one small group from one company would be of questionable value and likely be misleading. Socio-political issues aside, the key issue is economics. For this reason, the specific objectives of this study were to determine if the estimated PIUS plant cost will be competitive in the US market and to identify and evaluate the technical and licensing risks that might make PIUS uneconomical or otherwise unacceptable

  1. A computer code SPHINCS for sodium fire safety evaluation

    International Nuclear Information System (INIS)

    Yamaguchi, Akira

    2000-01-01

    A computer code SPHINCS solves coupled phenomena of thermal-hydraulics and sodium fire based on a multi-zone model. It deals with arbitrary number of rooms each of which is connected mutually by doorway and penetrations. With regard to the combustion phenomena, flame sheet model and liquid droplet combustion model are used for pool and spray fire, respectively, with the chemical equilibrium model using Gibbs free energy minimization method. The chemical reaction and mass and heat transfer are solved interactively. A specific feature of SPHINCS is detailed representation of thermal-hydraulics of a sodium pool and a steel liner, which is placed on the floor to prevent sodium-concrete contact. The author analyzed a series of pool combustion experiments, in which gas and liner temperatures are measured in detail. It has been found that good agreement is obtained and the SPHINCS has been validated with regard to the pool combustion phenomena. Further research needs are identified for the pool spreading modeling considering thermal deformation of liner and measurement of pool fluidity property of a mixture of liquid sodium and reaction products. SPHINCS code is to be used mainly in the safety evaluation of the consequence of sodium fire accident of liquid metal cooled fast reactor. (author)

  2. Methodology development for statistical evaluation of reactor safety analyses

    International Nuclear Information System (INIS)

    Mazumdar, M.; Marshall, J.A.; Chay, S.C.; Gay, R.

    1976-07-01

    In February 1975, Westinghouse Electric Corporation, under contract to Electric Power Research Institute, started a one-year program to develop methodology for statistical evaluation of nuclear-safety-related engineering analyses. The objectives of the program were to develop an understanding of the relative efficiencies of various computational methods which can be used to compute probability distributions of output variables due to input parameter uncertainties in analyses of design basis events for nuclear reactors and to develop methods for obtaining reasonably accurate estimates of these probability distributions at an economically feasible level. A series of tasks was set up to accomplish these objectives. Two of the tasks were to investigate the relative efficiencies and accuracies of various Monte Carlo and analytical techniques for obtaining such estimates for a simple thermal-hydraulic problem whose output variable of interest is given in a closed-form relationship of the input variables and to repeat the above study on a thermal-hydraulic problem in which the relationship between the predicted variable and the inputs is described by a short-running computer program. The purpose of the report presented is to document the results of the investigations completed under these tasks, giving the rationale for choices of techniques and problems, and to present interim conclusions

  3. Preliminary safety evaluation for a medical therapy reactor

    International Nuclear Information System (INIS)

    Jones, J.L.; Neuman, W.A.

    1989-01-01

    A conceptual design of a passively safe reactor facility for boron neutron capture therapy has been previously described. The medical therapy reactor (MTR) has a maximum power level of 10 MW(thermal) and utilizes 45 wt% uranium in UZrH, 20 wt% 235 U enriched hydride fuel matrix with 1 wt% erbium, which is a burnable poison and provides prompt negative reactivity feedback. The facility has five beam ports for patient treatment and advanced neutron beam research and is capable of 2,000 to 10,000 treatments per year, assuming single 8h/day, 5 day/week operation. The epithermal treatment flux from the beam ports is large, enabling single-session treatment of brain cancers of <10-min duration, with minimal fast neutron and gamma contaminants. The reactor core is designed with sufficient excess reactivity to yield a core lifetime equal to a facility lifetime of 30 yr. A preliminary safety evaluation was performed using the RELAP5 thermal-hydraulic code. The analysis addressed accidents in several major categories, including a pump coastdown, a loss of secondary heat sink, and a $0.5 step reactivity insertion

  4. Krypton-85 hydrofracture engineering feasibility and safety evaluation

    Energy Technology Data Exchange (ETDEWEB)

    Peretz, F.J.; Muller, M.E.; Pan, P.Y.

    1981-07-01

    Engineering studies have been made to determine the hazards associated with the disposal of /sup 85/Kr using the hydrofracture process. To assess the hazards, an effort has been made to identify the equipment required to entrain and dissolve the noble gas into the grout stream at hydrofracture pressure (up to 350 bar). Off-the-shelf or slightly modified equipment has been identified for safe and effective compression and gas-grout mixing. Each monthly injection disposes of 1.6 x 10/sup 6/ Ci of /sup 85/Kr. By connecting only one gas cylinder to the injection system at a time, the maximum amount of krypton likely to be released as a result of equipment failure is limited to 128,000 Ci. An evaluation by Los Alamos Technical Associates shows that releasing this amount of gas in less than one hour under worst-case meteorological conditions through a 30-m stack would result in a whole-body dose of 170 millirem at a distance of 1 km from the facility. A krypton collection and recovery system can further reduce this dose to 17 millirem; increasing the distance to the site boundary to 3 km can also reduce the dose by a factor of ten. Lung and skin dose estimates are 1.6 and 120 times the whole-body dose, respectively. These are all worst-case values; releases under more typical conditions would result in a significantly lower dose. No insurmountable safety or engineering problems have been identified.

  5. Evaluating Post-Earthquake Building Safety Using Economical MEMS Seismometers.

    Science.gov (United States)

    Hsu, Ting-Yu; Yin, Ren-Cheng; Wu, Yih-Min

    2018-05-05

    The earthquake early warning (EEW)-research group at National Taiwan University has been developing a microelectromechanical system-based accelerometer called “P-Alert”, designed for issuing EEWs. The main advantage of P-Alert is that it is a relatively economical seismometer. However, because of the expensive nature of commercial hardware for structural health monitoring (SHM) systems, the application of SHM to buildings remains limited. To determine the performance of P-Alert for evaluating post-earthquake building safety, we conducted a series of steel-frame shaking table tests with incremental damage. We used the fragility curves of different damage levels and the interstory drift ratios (calculated by the measured acceleration of each story using double integration and a filter) to gauge the potential damage levels. We concluded that the acceptable detection of damage for an entire building is possible. With improvements to the synchronization of the P-Alert sensors, we also anticipate a damage localization feature for the stories of a building.

  6. Krypton-85 hydrofracture engineering feasibility and safety evaluation

    International Nuclear Information System (INIS)

    Peretz, F.J.; Muller, M.E.; Pan, P.Y.

    1981-07-01

    Engineering studies have been made to determine the hazards associated with the disposal of 85 Kr using the hydrofracture process. To assess the hazards, an effort has been made to identify the equipment required to entrain and dissolve the noble gas into the grout stream at hydrofracture pressure (up to 350 bar). Off-the-shelf or slightly modified equipment has been identified for safe and effective compression and gas-grout mixing. Each monthly injection disposes of 1.6 x 10 6 Ci of 85 Kr. By connecting only one gas cylinder to the injection system at a time, the maximum amount of krypton likely to be released as a result of equipment failure is limited to 128,000 Ci. An evaluation by Los Alamos Technical Associates shows that releasing this amount of gas in less than one hour under worst-case meteorological conditions through a 30-m stack would result in a whole-body dose of 170 millirem at a distance of 1 km from the facility. A krypton collection and recovery system can further reduce this dose to 17 millirem; increasing the distance to the site boundary to 3 km can also reduce the dose by a factor of ten. Lung and skin dose estimates are 1.6 and 120 times the whole-body dose, respectively. These are all worst-case values; releases under more typical conditions would result in a significantly lower dose. No insurmountable safety or engineering problems have been identified

  7. Biological safety evaluation of the modified urinary catheter

    Energy Technology Data Exchange (ETDEWEB)

    Kowalczuk, Dorota, E-mail: dorota.kowalczuk@umlub.pl [Department of Medicinal Chemistry, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin (Poland); Przekora, Agata; Ginalska, Grazyna [Department of Biochemistry and Biotechnology, Medical University of Lublin, Chodzki 1, 20-093 Lublin (Poland)

    2015-04-01

    The purpose of this study was to evaluate in vitro safety of the novel tosufloxacin (TOS)-treated catheters with the prolonged antimicrobial activity. The test samples of silicone latex catheter were prepared by the immobilization of TOS on chitosan (CHIT)-coated catheter by means of covalent bonds and non-covalent interactions. Each step of the modification process of catheter surface was observed using ATR–Fourier transform infrared spectroscopy. In vitro cytotoxicity of the modified and unmodified catheters was assessed by direct and indirect tests in accordance with ISO standards using green monkey kidney (GMK) cell line. The MTT, lactate dehydrogenase activity (LDH), WST-8, Sulforhodamine B (SRB) test results and microscopic observation clearly indicated that unmodified silicone latex catheters decrease cell metabolic activity, act as a cytotoxic agent causing cell lysis and induce cell death through necrotic or apoptotic process. We suggest that chitosan coat with TOS immobilized limits leaching of harmful agents from silicone latex material, which significantly enhances survivability of GMK cells and therefore is quite a good protection against the cytotoxic effect of this material. - Highlights: • Characterization of the novel antimicrobial urinary catheters • Monitoring of the catheter modification by FTIR analysis • Confirmation of high cytotoxicity of latex-based catheter used in urological practice • Chitosan-coated and tosufloxacin-treated catheter is less toxic than the untreated one. • The proposed surface modification protects cells against latex-induced death.

  8. Haemolysis following rapid experimental red blood cell transfusion--an evaluation of two infusion pumps

    DEFF Research Database (Denmark)

    Hansen, Tom Giedsing; Sprogøe-Jakobsen, U; Pedersen, C M

    1998-01-01

    The vast majority of infusion pumps used for rapid transfusion of large amounts of blood have never been properly examined regarding their influence on the quality of the red blood cells (RBCs) infused. In this study, we evaluated the effect of two different infusion pumps on the degree of RBC...

  9. Clinical evaluation of Statstrip(R) Lactate for use in fetal scalp blood sampling

    NARCIS (Netherlands)

    Heinis, A.M.F.; Dillen, J. van; Oosting, J.D.; Rhose, S.; Vandenbussche, F.P.; Drongelen, J. van

    2017-01-01

    INTRODUCTION: Point-of-care testing of fetal scalp blood lactate is used as an alternative to pH analysis in fetal scalp blood sampling (FBS) during labor. Lactate measurements are not standardized and values vary with each device used. The aim of this study was to evaluate StatStrip(R) Lactate

  10. Safety evaluation of socket weld integrity in nuclear piping

    International Nuclear Information System (INIS)

    Choi, Y.H.; Kim, H.J.; Choi, S.Y.; Kim, Y.J.; Kim, Y.J.

    2004-01-01

    The purposes of this paper are to evaluate the integrity of socket weld in nuclear piping and prepare the technical basis for a new guideline on radiographic testing (RT) for the socket weld. Recently, the integrity of the socket weld is regarded as a safety concern in nuclear power plants because lots of failures and leaks have been reported in the socket weld. The root causes of the socket weld failure are known as unanticipated loadings such as vibration or thermal fatigue and improper weld joint during construction. The ASME Code sec. III requires 1/16 inch gap between the pipe and fitting in the socket weld. Many failure cases, however, showed that the gap requirement was not satisfied. The Code also requires magnetic particle examination (MT) or liquid penetration examination (PT) on the socket weld, but not radiographic examination (RT). It means that it is not easy to examine the 1/16 inch gap in the socket weld by using the NDE methods currently required in the Code. In this paper, the effects of the requirements in the ASME Code sec. III on the socket weld integrity were evaluated by using finite element method. The crack behavior in the socket weld was also investigated under vibration event in nuclear power plants. The results showed that the socket weld was very susceptible to the vibration if the requirements in ASME Code were not satisfied. The constraint between the pipe and fitting due to the contact significantly affects the integrity of the socket weld. This paper also suggests a new guideline on the RT for the socket weld during construction stage in nuclear power plants. (orig.)

  11. Patient safety with blood products administration using wireless and bar-code technology.

    Science.gov (United States)

    Porcella, Aleta; Walker, Kristy

    2005-01-01

    Supported by a grant from the Agency for Healthcare Research and Quality, a University of Iowa Hospitals and Clinics interdisciplinary research team created an online data-capture-response tool utilizing wireless mobile devices and bar code technology to track and improve blood products administration process. The tool captures 1) sample collection, 2) sample arrival in the blood bank, 3) blood product dispense from blood bank, and 4) administration. At each step, the scanned patient wristband ID bar code is automatically compared to scanned identification barcode on requisition, sample, and/or product, and the system presents either a confirmation or an error message to the user. Following an eight-month, 5 unit, staged pilot, a 'big bang,' hospital-wide implementation occurred on February 7, 2005. Preliminary results from pilot data indicate that the new barcode process captures errors 3 to 10 times better than the old manual process.

  12. Continuous Postoperative Pericardial Flushing: A Pilot Study on Safety, Feasibility, and Effect on Blood Loss

    Directory of Open Access Journals (Sweden)

    Johan S.J. Manshanden

    2015-09-01

    Conclusions: CPPF after cardiac surgery was found to be safe and feasible in this experimental setting. The clinically relevant effect on blood loss needs to be confirmed in a randomized clinical trial.

  13. Safety evaluation report. Fast Flux Test Facility. Project No. 448

    Energy Technology Data Exchange (ETDEWEB)

    1978-08-01

    Information on the safety of the FFTF Reactor is presented under the following chapter headings: site characteristics; design of structures, components, equipment, and systems; reactor; reactor coolant system and connected systems; engineered safety features; electric power; auxiliary systems; radioactive waste management systems; radiation protection; conduct of operations; initial test programs; accident analysis; and quality assurance.

  14. Safety evaluation report. Fast Flux Test Facility. Project No. 448

    International Nuclear Information System (INIS)

    1978-01-01

    Information on the safety of the FFTF Reactor is presented under the following chapter headings: site characteristics; design of structures, components, equipment, and systems; reactor; reactor coolant system and connected systems; engineered safety features; electric power; auxiliary systems; radioactive waste management systems; radiation protection; conduct of operations; initial test programs; accident analysis; and quality assurance

  15. Safety re-evaluation of the HOR reactor

    International Nuclear Information System (INIS)

    Verkooijen, A.H.M.; Vries, J.W. de

    2001-01-01

    State. Requirement C16 in the new licence asks for a periodical integral safety re-evaluation of the HOR reactor every 10 years and starting after 2 years

  16. Insight into "Calculated Risk": An Application to the Prioritization of Emerging Infectious Diseases for Blood Transfusion Safety.

    Science.gov (United States)

    Neslo, R E J; Oei, W; Janssen, M P

    2017-09-01

    Increasing identification of transmissions of emerging infectious diseases (EIDs) by blood transfusion raised the question which of these EIDs poses the highest risk to blood safety. For a number of the EIDs that are perceived to be a threat to blood safety, evidence on actual disease or transmission characteristics is lacking, which might render measures against such EIDs disputable. On the other hand, the fact that we call them "emerging" implies almost by definition that we are uncertain about at least some of their characteristics. So what is the relative importance of various disease and transmission characteristics, and how are these influenced by the degree of uncertainty associated with their actual values? We identified the likelihood of transmission by blood transfusion, the presence of an asymptomatic phase of infection, prevalence of infection, and the disease impact as the main characteristics of the perceived risk of disease transmission by blood transfusion. A group of experts in the field of infectious diseases and blood transfusion ranked sets of (hypothetical) diseases with varying degrees of uncertainty associated with their disease characteristics, and used probabilistic inversion to obtain probability distributions for the weight of each of these risk characteristics. These distribution weights can be used to rank both existing and newly emerging infectious diseases with (partially) known characteristics. Analyses show that in case there is a lack of data concerning disease characteristics, it is the uncertainty concerning the asymptomatic phase and the disease impact that are the most important drivers of the perceived risk. On the other hand, if disease characteristics are well established, it is the prevalence of infection and the transmissibility of the disease by blood transfusion that will drive the perceived risk. The risk prioritization model derived provides an easy to obtain and rational expert assessment of the relative importance of

  17. Safety and Observations from a Placebo-Controlled, Crossover Study to Assess Use of Autologous Umbilical Cord Blood Stem Cells to Improve Symptoms in Children with Autism.

    Science.gov (United States)

    Chez, Michael; Lepage, Christopher; Parise, Carol; Dang-Chu, Ashley; Hankins, Andrea; Carroll, Michael

    2018-04-01

    The aim of this exploratory study was to assess the safety and clinical effects of autologous umbilical cord blood (AUCB) infusion in children with idiopathic autism spectrum disorder (ASD). Twenty-nine children 2 to 6 years of age with a confirmed diagnosis of ASD participated in this randomized, blinded, placebo-controlled, crossover trial. Participants were randomized to receive AUCB or placebo, evaluated at baseline, 12, and 24 weeks, received the opposite infusion, then re-evaluated at the same time points. Evaluations included assessments of safety, Expressive One Word Picture Vocabulary Test, 4th edition, Receptive One Word Picture Vocabulary Test, 4th edition, Clinical Global Impression, Stanford-Binet Fluid Reasoning and Knowledge, and the Vineland Adaptive Behavior and Socialization Subscales. Generalized linear models were used to assess the effects of the response variables at the 12- and 24-week time periods under each condition (AUCB, placebo). There were no serious adverse events. There were trends toward improvement, particularly in socialization, but there were no statistically significant differences for any endpoints. The results of this study suggest that autologous umbilical cord infusions are safe for children with ASD. Tightly controlled trials are necessary to further progress the study of AUCB for autism. Stem Cells Translational Medicine 2018;7:333-341. © 2018 The Authors Stem Cells Translational Medicine published by Wiley Periodicals, Inc. on behalf of AlphaMed Press.

  18. Safety culture evaluation and asset root cause analysis

    International Nuclear Information System (INIS)

    Okrent, D.; Xiong, Y.

    1995-01-01

    This paper examines the role of organizational and management factors in nuclear power plant safety through the use of operating experiences. The ASSET (Assessment of Safety Significant Events Team) reports of thirteen plants (total thirty events) have been analyzed in term of twenty organizational dimensions (factors) identified by Brookhaven National Laboratory and Pennsylvania State University. For three plants detailed results are reported in this paper. The results of thirteen plants are summarized in the form of a table. The study tends to confirm that organizational and management factors play an important role in plant safety. The twenty organizational dimensions and their definitions, in general, were adequate in this study. Formalization, Safety Culture, Technical Knowledge, Training, Roles-Responsibilities and Problem Identification appear to be key organizational factors which influence the safety of nuclear power plants studied

  19. Evaluation of hepatic blood flow using 99mTc-GSA in rats with hepatic blood flow manipulation

    International Nuclear Information System (INIS)

    Hiraguchi, Etsuo

    1995-01-01

    Blood clearance and hepatic uptake parameters of 99m Tc-DTPA-galactosyl human serum albumin ( 99m Tc-GSA) were evaluated in two groups of rats, normal liver group and CCl 4 induced chronic liver injury group. In each group, four subgroups were classified as follows: simple laparotomy (LAP), hepatic artery ligation (HAL), portal vein ligation (PVL) and both hepatic artery and portal vein ligation (HAL+PVL). 99m Tc-GSA was intravenously injected (50 μg/100 g B.W.) to rats. Heart and liver were targetted as region of interest and time activity curves (TACs) were obtained. The blood clearance parameters (HH4 and Kd) and the hepatic uptake parameters (LHL4 and Ku) were calculated from these TACs. In normal liver group, the mean HH4 of LAP was significantly different from those of PVL and HAL+PVL. Similarly, the other three parameters (LHL4, Kd and Ku) of LAP were significantly different from those of PVL and HAL+PVL. CCl 4 induced chronic liver injury group showed significant difference on all four parameters in four subgroups. Hepatic tissue blood flow rates (HTBFR) calculated by Laser Doppler flowmeter correlated well with 99m Tc-GSA parameters in both groups. These results suggest that 99m Tc-GSA is useful to estimate hepatic blood flow not only in rats with normal liver, but also in rats with CCl 4 induced chronic liver injury. (author)

  20. Evaluation of the use of shock index in identifying acute blood loss in healthy blood donor dogs.

    Science.gov (United States)

    McGowan, Erin E; Marryott, Kimberly; Drobatz, Kenneth J; Reineke, Erica L

    2017-09-01

    To determine if shock index (SI) would increase following blood donation and if it would be a more sensitive assessment of acute blood loss as compared with heart rate (HR), blood pressure, and plasma lactate. Prospective study. University teaching hospital. Twenty client-owned clinically normal dogs. Peripheral venous blood measurements and blood donation. Data were collected at 3 time points: prior to donation (T pre ), immediately after donation (T 0 ), and 10 minutes following completion of donation (T 10 ). HR and systolic blood pressure (SBP) were recorded and used to calculate SI at time points T pre , T 0 , and T 10 . Packed cell volume (PCV), total plasma protein (TPP), and plasma lactate were evaluated from a peripheral venous blood sample at T pre and T 10. The mean SI was significantly increased at both time points following blood donation as compared to baseline (SI pre = 0.88 ± 0.19 vs SI 0 = 1.17 ± 0.21 vs SI 10 = 1.12 ± 0.25 (P = 0.0002 and 0.0003, respectively). Following blood donation, the mean SBP was significantly lower (SBP pre = 149 ± 24 mm Hg, SBP 0 = 118 ± 20 mm Hg; P = 0.0001, SBP 10 = 133 ± 21 mm Hg; P = 0.011). The mean HR was not significantly different at T 0 but was significantly increased at T 10 (HR pre = 128 ± 21/min, HR 0 = 136 ± 25/min, P = 0.193; HR 10 = 146 ± 29/min, P = 0.003). There was no significant difference in mean PCV (PCV pre = 50 ± 4%, PCV 10 = 48 ± 4%, P = 0.08). The mean TPP and plasma lactate were significantly different following donation but still within the reference interval (TPP pre = 6.8 ± 0.4 g/dL, TPP 10 = 6.4 ± 0.4 g/dL, P = 0.0014; Lac pre = 1.7 ± 0.7mmol/L, Lac 10 = 1.9 ± 0.8 mmol/L, P = 0.04). A receiver operating characteristic (ROC) analysis comparing area under the curve (AUC) for SI, HR, and SBP at T 0 and T 10 compared to T pre found that SI (AUC at T 0 : 0.858, CI: 0.730, 0.984 AUC at T 10 : 0.769 CI: 0.617, 0.921) was a better indicator of blood loss

  1. N-13 ammonia for the noninvasive evaluation of myocardial blood flow by positron emission computed tomography

    International Nuclear Information System (INIS)

    Schelbert, H.R.; Phelps, M.E.

    1979-01-01

    The kinetics and characteristics of nitrogen-13 labelled ammonia as an indicator of blood flow in the myocardium were evaluated in open-chest dogs. Its utility as an imaging agent was tested in animals and man

  2. Blood gas analyzer utility in evaluating oxygen kinetics of the aqueous humor

    Directory of Open Access Journals (Sweden)

    Ismail Ersan

    2015-04-01

    Full Text Available Purpose: To measure the partial pressure of oxygen (PO2 and carbon dioxide (PCO2 and the pH of aqueous humor (AH and arterial blood samples from rabbits using a blood gas analyzer. Methods: Twenty New Zealand rabbits were anesthetized intramuscularly with ketamine and xylazine and were then allowed to breathe room air. Using a gas blood analyzer, arterial blood and AH samples were analyzed for PO2, PCO2, and pH. Results: The mean arterial blood pressure was 87.14 ± 15.0 mmHg. The mean blood and AH PO2 were 95.18 ± 11.76 mmHg and 88.83 ± 9.92 mmHg, the mean blood and AH PCO2 were 25.86 ± 5.46 mmHg and 29.50 ± 5.36 mmHg, and the mean blood and AH pH were 7.38 ± 0.06 and 7.33 ± 0.09, respectively. Conclusion: Conclusions: The blood gas analyzer was easily employed to evaluate the aqueous humor in rabbits. When comparing the results of studies evaluating aqueous PO2, care should be taken to determine the methods used in these studies.

  3. Determination of safety margins for whole blood concentrations of alcohol and nineteen drugs in driving under the influence cases.

    Science.gov (United States)

    Kristoffersen, Lena; Strand, Dag Helge; Liane, Veronica Horpestad; Vindenes, Vigdis; Tvete, Ingunn Fride; Aldrin, Magne

    2016-02-01

    Legislative limits for driving under the influence of 20 non-alcohol drugs were introduced in Norway in February 2012. Per se limits corresponding to blood alcohol concentrations (BAC) of 0.2g/kg were established for 20 psychoactive drugs, and limits for graded sanctions corresponding to BACs of 0.5 and 1.2g/kg were determined for 13 of these drugs. This new legislation made it possible for the courts to make sentences based on the analytical results, similar to the situation for alcohol. To ensure that the reported concentration is as least as high as the true concentration, with a 99% safety level, safety margins had to be calculated for each of the substances. Diazepam, tetrahydrocannabinol (THC) and alcohol were used as model substances to establish a new model for estimating the safety margins. The model was compared with a previous used model established several years ago, by a similar yet much simpler model, and they were found to be in agreement. The measurement uncertainties depend on the standard batch used, the work list and the measurements' replicate. A Bayesian modelling approach was used to determine the parameters in the model, using a dataset of 4700 diazepam positive specimens and 5400 THC positive specimens. Different safety margins were considered for low and high concentration levels of diazepam (≤2μM (0.6mg/L) and >2μM) and THC (≤0.01μM (0.003mg/L) and >0.01μM). The safety margins were for diazepam 19.5% (≤2μM) and 34% (>2μM), for THC 19.5% (≤0.01μM) and 24.9% (>0.01μM). Concentration dependent safety margins for BAC were based on a dataset of 29500 alcohol positive specimens, and were in the range 10.4% (0.1g/kg) to 4.0% (4.0g/kg) at a 99% safety level. A simplified approach was used to establish safety margins for the compounds amphetamine, MDMA, methamphetamine, alprazolam, phenazepam, flunitrazepam, clonazepam, nitrazepam, oxazepam, buprenorphine, GHB, methadone, ketamine, cocaine, morphine, zolpidem and zopiclone. The

  4. Dynamic probability evaluation of safety levels of earth-rockfill dams using Bayesian approach

    Directory of Open Access Journals (Sweden)

    Zi-wu Fan

    2009-06-01

    Full Text Available In order to accurately predict and control the aging process of dams, new information should be collected continuously to renew the quantitative evaluation of dam safety levels. Owing to the complex structural characteristics of dams, it is quite difficult to predict the time-varying factors affecting their safety levels. It is not feasible to employ dynamic reliability indices to evaluate the actual safety levels of dams. Based on the relevant regulations for dam safety classification in China, a dynamic probability description of dam safety levels was developed. Using the Bayesian approach and effective information mining, as well as real-time information, this study achieved more rational evaluation and prediction of dam safety levels. With the Bayesian expression of discrete stochastic variables, the a priori probabilities of the dam safety levels determined by experts were combined with the likelihood probability of the real-time check information, and the probability information for the evaluation of dam safety levels was renewed. The probability index was then applied to dam rehabilitation decision-making. This method helps reduce the difficulty and uncertainty of the evaluation of dam safety levels and complies with the current safe decision-making regulations for dams in China. It also enhances the application of current risk analysis methods for dam safety levels.

  5. WHO Safety Surgical Checklist implementation evaluation in public hospitals in the Brazilian Federal District

    Directory of Open Access Journals (Sweden)

    Heiko T. Santana

    2016-09-01

    Full Text Available Summary: The World Health Organization (WHO created the WHO Surgical Safety Checklist to prevent adverse events in operating rooms. The aim of this study was to analyze WHO checklist implementation in three operating rooms of public hospitals in the Brazilian Federal District. A prospective cross-sectional study was performed with pre- (Period I and post (Period II-checklist intervention evaluations. A total of 1141 patients and 1052 patients were studied in Periods I and II for a total of 2193 patients. Period I took place from December 2012 to March 2013, and Period II took place from April 2013 to August 2014. Regarding the pre-operatory items, most surgeries were classified as clean-contaminated in both phases, and team attire improved from 19.2% to 71.0% in Period II. Regarding checklist adherence in Period II, “Patient identification” significantly improved in the stage “Before induction of anesthesia”. “Allergy verification”, “Airway obstruction verification”, and “Risk of blood loss assessment” had low adherence in all three hospitals. The items in the stage “Before surgical incision” showed greater than 90.0% adherence with the exception of “Anticipated critical events: Anesthesia team review” (86.7% and “Essential imaging display” (80.0%. Low adherence was noted in “Instrument counts” and “Equipment problems” in the stage “Before patient leaves operating room”. Complications and deaths were low in both periods. Despite the variability in checklist item compliance in the surveyed hospitals, WHO checklist implementation as an intervention tool showed good adherence to the majority of the items on the list. Nevertheless, motivation to use the instrument by the surgical team with the intent of improving surgical patient safety continues to be crucial. Keywords: Surgical checklist, Adverse events, Patient safety, Surgical team, Infection control

  6. Development of safety evaluation guidelines for base-isolated buildings in Japan

    International Nuclear Information System (INIS)

    Aoyama, Hiroyuki

    1989-01-01

    This paper describes the safety evaluation guidelines and the review process for non-nuclear base-isolated buildings proposed for construction in Japan. The paper discusses the guidelines application for two types of soil: hard soil and intermediate soil (soft soil was excluded.); safety evaluation items included in the level C design review; and safety margin of base isolation. Lessons learned through these design review efforts have potential applicability to design of seismic base isolation for nuclear power plants

  7. Guidelines for preparing criticality safety evaluations at Department of Energy non-reactor nuclear facilities

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-09-01

    This Department of Energy (DOE) is approved for use by all components of DOE. It contains guidelines that should be followed when preparing Criticality Safety Evaluations that will be used to demonstrate the safety of operations performed at DOE Non-Reactor Nuclear Facilities. Adherence with these guidelines will provide consistency and uniformity in Criticality Safety Evaluations (CSEs) across the complex and will document compliance with DOE Order 5480.24 requirements as they pertain to CSEs.

  8. Guidelines for preparing criticality safety evaluations at Department of Energy non-reactor nuclear facilities

    International Nuclear Information System (INIS)

    1998-09-01

    This Department of Energy (DOE) is approved for use by all components of DOE. It contains guidelines that should be followed when preparing Criticality Safety Evaluations that will be used to demonstrate the safety of operations performed at DOE Non-Reactor Nuclear Facilities. Adherence with these guidelines will provide consistency and uniformity in Criticality Safety Evaluations (CSEs) across the complex and will document compliance with DOE Order 5480.24 requirements as they pertain to CSEs

  9. An Evaluation of Intra‑ and Post‑operative Blood Loss in Total Hip ...

    African Journals Online (AJOL)

    2017-05-18

    May 18, 2017 ... Results: The mean intra‑ and post‑operative blood losses were 1222.7 ... To evaluate blood loss after total hip replacement. 2. To evaluate the .... 12.3. 4.2. 0.1. Median. 400.0. 150.0. 20.0. 3.0. Mode. 400.0. 100.0. 0.0. 3.0. SD.

  10. In vivo evaluation of femoral blood flow measured with magnetic resonance

    International Nuclear Information System (INIS)

    Henriksen, O.; Staahlberg, F.; Thomsen, C.; Moegelvang, J.; Persson, B.; Lund Univ.

    1989-01-01

    Quantitative measurements of blood flow based on magnetic resonance imaging (MRI) using conventional multiple spin echo sequences were evaluated in vivo in healthy young volunteers. Blood flow was measured using MRI in the femoral vein. The initial slope of the multiple spin echo decay curve, corrected for the T2 decay of non-flowing blood was used to calculate the blood flow. As a reference, the blood flow in the femoral artery was measured simultaneously with an invasive indicator dilution technique. T2 of non-flowing blood was measured in vivo in popliteal veins during regional circulatory arrest. The mean T2 of non-flowing blood was found to be 105±31 ms. The femoral blood flow ranged between 0 and 643 ml/min measured with MRI and between 280 and 531 ml/min measured by the indicator dilution technique. There was thus poor agreement between the two methods. The results indicate that in vivo blood flow measurements made with MRI based on wash-out effects, commonly used in multiple spin echo imaging, do not give reliable absolute values for blood flow in the femoral artery or vein. (orig.)

  11. Evaluation of arterial blood gases and arterial blood pressures in brachycephalic dogs.

    Science.gov (United States)

    Hoareau, G L; Jourdan, G; Mellema, M; Verwaerde, P

    2012-01-01

    Brachycephalic dogs (BD) are prone to congenital upper airway obstruction (brachycephalic syndrome, BS). In humans suffering from sleep apnea, upper airway obstruction is known to cause hypertension. There is no information regarding the influence of BS in dogs on cardiorespiratory physiology. BD are prone to lower P(a) O(2), higher P(a) CO (2), and hypertension compared with meso- or dolicocephalic dogs (MDD). Eleven BD and 11 MDD. After a questionnaire was completed by the owner, a physical examination was performed. Height and thoracic circumferences were measured. Arterial blood gases, electrolyte concentrations, and packed cell volume (PCV) were measured. Systolic (SAP), mean (MAP), and diastolic (DAP) arterial blood pressure recordings were performed. A total of 7 French and 4 English bulldogs met the inclusion criteria. The control group consisted in 6 Beagles, 2 mixed breed dogs, 1 Staffordshire Bull Terrier, 1 Parson Russell Terrier, and 1 Australian Cattle Dog. Statistically, BD had lower P(a) O(2), higher P(a) CO2, and higher PCV when compared with controls (86.2 ± 15.9 versus 100.2 ± 12.6 mmHg, P = .017; 36.3 ± 4.6 versus 32.7 ± 2.6 mmHg, P = .019; 48.2 ± 3.5 versus 44.2 ± 5.4%, P = .026, respectively). Also, they had significantly higher SAP (177.6 ± 25.0 versus 153.5 ± 21.7 mmHg, P = .013), MAP (123.3 ± 17.1 versus 108.3 ± 12.2 mmHg, P = .014), and DAP (95.3 ± 19.2 versus 83.0 ± 11.5 mmHg, P = .042). BD with a P(a) CO (2) >35 mmHg were significantly older than those with a P(a) CO (2) ≤35 mmHg (58 ± 16 and 30 ± 11 months, P = .004). Results of this study suggest that some BD are prone to lower P(a) O(2), higher P(a) CO (2), and hypertension when compared with MDD. Age may be a contributing factor. Copyright © 2012 by the American College of Veterinary Internal Medicine.

  12. The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility.

    Science.gov (United States)

    Edgren, Gustaf; Rostgaard, Klaus; Vasan, Senthil K; Wikman, Agneta; Norda, Rut; Pedersen, Ole Birger; Erikstrup, Christian; Nielsen, Kaspar René; Titlestad, Kjell; Ullum, Henrik; Melbye, Mads; Nyrén, Olof; Hjalgrim, Henrik

    2015-07-01

    Risks of transfusion-transmitted disease are currently at a record low in the developed world. Still, available methods for blood surveillance might not be sufficient to detect transmission of diseases with unknown etiologies or with very long incubation periods. We have previously created the anonymized Scandinavian Donations and Transfusions (SCANDAT) database, containing data on blood donors, blood transfusions, and transfused patients, with complete follow-up of donors and patients for a range of health outcomes. Here we describe the re-creation of SCANDAT with updated, identifiable data. We collected computerized data on blood donations and transfusions from blood banks covering all of Sweden and Denmark. After data cleaning, two structurally identical databases were created and the entire database was linked with nationwide health outcomes registers to attain complete follow-up for up to 47 years regarding hospital care, cancer, and death. After removal of erroneous records, the database contained 25,523,334 donation records, 21,318,794 transfusion records, and 3,692,653 unique persons with valid identification, presently followed over 40 million person-years, with possibility for future extension. Data quality is generally high with 96% of all transfusions being traceable to their respective donation(s) and a very high (>97%) concordance with official statistics on annual number of blood donations and transfusions. It is possible to create a binational, nationwide database with almost 50 years of follow-up of blood donors and transfused patients for a range of health outcomes. We aim to use this database for further studies of donor health, transfusion-associated risks, and transfusion-transmitted disease. © 2015 AABB.

  13. Applying a realistic evaluation model to occupational safety interventions

    DEFF Research Database (Denmark)

    Pedersen, Louise Møller

    2018-01-01

    Background: Recent literature characterizes occupational safety interventions as complex social activities, applied in complex and dynamic social systems. Hence, the actual outcomes of an intervention will vary, depending on the intervention, the implementation process, context, personal characte......Background: Recent literature characterizes occupational safety interventions as complex social activities, applied in complex and dynamic social systems. Hence, the actual outcomes of an intervention will vary, depending on the intervention, the implementation process, context, personal...... and qualitative methods. This revised model has, however, not been applied in a real life context. Method: The model is applied in a controlled, four-component, integrated behaviour-based and safety culture-based safety intervention study (2008-2010) in a medium-sized wood manufacturing company. The interventions...... involve the company’s safety committee, safety manager, safety groups and 130 workers. Results: The model provides a framework for more valid evidence of what works within injury prevention. Affective commitment and role behaviour among key actors are identified as crucial for the implementation...

  14. The art of appropriate evaluation : a guide for highway safety program managers

    Science.gov (United States)

    2008-08-01

    The guide, updated from its original release in 1999, is intended for project managers who will oversee the evaluation of traffic safety programs. It describes the benefits of evaluation and provides an overview of the steps involved. The guide inclu...

  15. A framework of risk-informed seismic safety evaluation of nuclear power plants in Japan

    International Nuclear Information System (INIS)

    Kondo, S.; Sakagami, M.; Hirano, M.; Shiba, M.

    2001-01-01

    A framework of risk-informed seismic design and safety evaluation of nuclear power plants is under consideration in Japan so as to utilize the progress in the seismic probabilistic safety assessment methodology. Issues resolved to introduce this framework are discussed after the concept, evaluation process and characteristics of the framework are described. (author)

  16. Expert opinions on the acceptance of alternative methods in food safety evaluations

    NARCIS (Netherlands)

    Punt, Ans; Bouwmeester, Hans; Schiffelers, Marie Jeanne W.A.; Peijnenburg, Ad A.C.M.

    2018-01-01

    Inclusion of alternative methods that replace, reduce, or refine (3R) animal testing within regulatory safety evaluations of chemicals generally faces many hurdles. The goal of the current work is to i) collect responses from key stakeholders involved in food safety evaluations on what they consider

  17. Evaluation of safety of Hammada salicornica in cell culture

    Directory of Open Access Journals (Sweden)

    F. Hosseini Hamedani

    2017-11-01

    Full Text Available Background and objectives: A pharmaceutical products that is planned to be used in clinic, should not only have beneficial effects but also be safe too. Preclinical studies in animals are costly and need considering ethical issues. Cell culture can be used before animal tests. Considering useful effects of these methods, we have evaluated safety of total methanol extract of Hammada salicornica and its aqueous and petroleum ether fractions in cell culture.Methods: Total methanol extract was prepared with the standard method of maceration. Different fractions were prepared by liquid-liquid fractionation and the extracts were then dried with rotary evaporator. After determination of bactericidal concentration of the extracts, 400 ug/mL, the cytotoxicity was tested at various concentrations regarding the minimum antibacterial concentration by MTT test. Hep-2c and VERO cell lines were used in MTT test. A range of concentrations (10-500 ug/mL of the extracts were prepared and were added to about 70% confluent 96 well plates. After exposure for 48 h, MTT solution was added to the wells, and 4 h later formazan crystals were solubilized and optical densities were read at 570 nm. Results: Cytotoxicity Index was calculated and significance test was performed using t-test comparing the Index of the test and control group at each concentration. No significant difference was observed. Conclusion: Various fractions of H. salicornica were not cytotoxic at concentrations above bactericidal concentrations (up to 500 ug/mL. The results need to be confirmed in animal studies before using in human subjects.

  18. Evaluation of the efficiency and safety in cosmetic products.

    Science.gov (United States)

    Uckaya, Meryem; Uckaya, Fatih; Demir, Nazan; Demir, Yasar

    2016-02-29

    Chemicals used in cosmetics have to interact with enzymes for beneficial or destroy purpose after they enter in our body. Active sections of enzymes that catalyze reactions have three dimensions and they are active optically. When these limitations of catalytic sections are considered, it may be considered that defining geometric specifications of chemical materials and functional groups they contain may contribute on safety evaluations of cosmetic products. In this study, defining similarities and differences of geometric structures of chemicals that are prohibited to be used in cosmetic products and chemical that are allowed to be used by using group theory and analyze of functional groups that are often encountered in these chemicals are aimed. Molecule formulas related to chemical material of, 276 pieces chemicals that are prohibited to be used in cosmetic products and 65 pieces chemicals that are allowed, are used as the material. Two and three-dimension structures of these formulas are drawn and types and quantity of functional groups they contain are defined. And as a method, freeware (Free Trial) version of "Chem-BioOffice Ultra 13.0 Suite" chemical drawing program to draw two and three-dimension of formulas, "Campus-Licensed" version that are provided for use by our university of "Autodesk 3DS Max" for three-dimension drawings are used. In order to analyze geometric specifications of drawn molecules according to Group Theory and define type and quantity of available functional groups, Excel applications developed by Prof. Dr. Yaşar Demir are used. Copyright © 2016 Elsevier B.V. All rights reserved.

  19. SAFETY

    CERN Multimedia

    Niels Dupont

    2013-01-01

    CERN Safety rules and Radiation Protection at CMS The CERN Safety rules are defined by the Occupational Health & Safety and Environmental Protection Unit (HSE Unit), CERN’s institutional authority and central Safety organ attached to the Director General. In particular the Radiation Protection group (DGS-RP1) ensures that personnel on the CERN sites and the public are protected from potentially harmful effects of ionising radiation linked to CERN activities. The RP Group fulfils its mandate in collaboration with the CERN departments owning or operating sources of ionising radiation and having the responsibility for Radiation Safety of these sources. The specific responsibilities concerning "Radiation Safety" and "Radiation Protection" are delegated as follows: Radiation Safety is the responsibility of every CERN Department owning radiation sources or using radiation sources put at its disposition. These Departments are in charge of implementing the requi...

  20. The safety evaluation guide for laboratories and plants a tool for enhancing safety

    International Nuclear Information System (INIS)

    Lhomme, Veronique; Daubard, Jean-Paul

    2013-01-01

    The Institute for Radioprotection and Nuclear Safety (IRSN) acts as technical support for the French government Authorities competent in nuclear safety and radiation protection for civil and defence activities. In this frame, the Institute's performs safety assessments of the safety cases submitted by operators to these Authorities for each stage in the life cycle of a nuclear facility, including dismantling operations, which is subjected to a licensing procedure. In the fuel cycle field, this concerns a large variety of facilities. Very often, depending on facilities and on safety cases, safety assessment to be performed is multidisciplinary and involves the supervisor in charge of the facility and several safety experts, particularly to cover the whole set of risks (criticality, exposure to radiation, fire, handling, containment, human and organisational factors...) encountered during facility's operations. Taking these into account, and in order to formalize the assessment process of the fuel cycle facilities, laboratories, irradiators, particle accelerators, under-decommissioning reactors and radioactive waste management, the 'Plants, Laboratories, Transports and Waste Safety' Division of IRSN has developed an internal guide, as a tool: - To present the methodological framework, and possible specificities, for the assessment according to the 'Defence in Depth Concept' (Part 1); - To provide key questions associated to the necessary contradictory technical review of the safety cases (Part 2); - To capitalise on experience on the basis of technical examples (coming from incident reports, previous safety assessments...) demonstrating the questioning (Part 3). The guide is divided in chapters, each dedicated to a type of risk (dissemination of radioactive material, external or internal exposure from ionising radiation, criticality, radiolysis mechanisms, handling operations, earthquake, human or organisational factors...) or to a type

  1. Study on uncertainty evaluation system for the safety evaluation of interim spent fuel storage facility

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Myung Hyeon; Shin, Myeong Won; Rhy, Seok Jin; Cho, Dong Keon; Park, Dong Hwan [Kyunghee Univ., Seoul (Korea, Republic of); Cheong, Beom Jin [Minstry of Science and Technology, Gwacheon (Korea, Republic of)

    1998-03-15

    The main objective os to develop a technical standards for the facility operation of the interm, spent fuel storage facility and to develop a draft for the technical criteria to be legislated. The another objective os to define a uncertainty evaluation system for burn up credit application in criticality analysis and to investigate an applicability of this topic for future regulatory activity. Investigate a status of art for the operational criteria of spent fuel interm wet storage. Collect relevant laws, decree, notices and standards related to the operation of storage facility and study on the legislation system. Develop a draft of technical standards and criteria to be legislated. Define an evaluation system for the uncertainty analysis and study on the status of art in the field of criticality safety analysis. Develop an uncertainty evaluation system in criticality analysis with burnup credit and investigate an applicability as well as its benefits of this policy.

  2. Safety Culture Evaluation at Research Reactors of Pakistan Atomic Energy Commission

    International Nuclear Information System (INIS)

    Qamar, M.A.; Saeed, A.; Shah, J.H.

    2016-01-01

    The concept of safety culture was presented by IAEA in document INSAG-4 (1991), delineated as “assembly of characteristics and attitudes in organizations and individuals which establish that, as an overriding priority, nuclear plant safety issues receive the attention warranted by their significance”. The purpose of this paper is to describe the evaluation of safety culture at research reactors of the Pakistan Atomic Energy Commission (PAEC). Evaluating the safety culture of a particular organization poses some challenges which can be resolved by using safety culture evaluation models like those of Sachein (1992) and Harber-Barrier(1998). In PAEC, safety culture is the integral part of management system which not only promotes safety culture throughout the organization but also enhances its significance. To strengthen the safety culture, PAEC is also participating in a number of international and regional meetings of IAEA regarding safety culture. PAEC and the national regulator Pakistan Nuclear Regulatory Authority (PNRA) are also arranging workshops, peer reviews, sharing operational experiences and interacting with IAEA missions to enhance its capabilities in the field of safety culture. The Directorate General of Safety (DOS) is a corporate office of PAEC for safety and regulatory matters. DOS is in the process of implementing a program to evaluate safety culture at nuclear installations of PAEC to ensure that safety culture is included as a vital segment of the Integral Management System of the establishment. In this regard, training sessions and lectures on safety culture evaluation are normally conducted in PAEC for awareness and enhancement of the safety culture program. Safety culture is also addressed in PNRA Regulations like PAK-909 and PAK-913. In this paper we will focus on the safety culture evaluation in our research reactors, i.e., PARR-1 and PARR-2. The evaluation results will be based on observations, interviews of employees, group discussions

  3. Half a decade of mini-pool nucleic acid testing: Cost-effective way for improving blood safety in India

    Directory of Open Access Journals (Sweden)

    Shivaram Chandrashekar

    2014-01-01

    Full Text Available Background and Objectives: It is well established that Nucleic acid testing (NAT reduces window phase of transfusion transmissible infections (TTI and helps improve blood safety. NAT testing can be done individually or in pools. The objectives of this study were to determine the utility, feasibility and cost effectiveness of an in-house minipool-NAT(MP-NAT. Materials and Methods: Blood donors were screened by history, tested by ELISA and sero-negative samples were subjected to an in-house NAT by using reverse transcriptase-polymerase chain reaction (RT-PCR. Testing was done in mini-pools of size eight (8. Positive pools were repeated with individual samples. Results: During the study period of Oct 2005-Sept 2010 (5 years all blood donors (n=53729 were screened by ELISA. Of which 469 (0.87% were positive for HIV-1, HBV or HCV. Sero-negative samples (n=53260 were screened by in-house MP-NAT. HIV-NAT yield was 1/53260 (n=1 and HBV NAT yield (n=2 was 1/26630. Conclusion: NAT yield was lower than other India studies possibly due to the lower sero-reactivity amongst our donors. Nevertheless it intercepted 9 lives including the components prepared. The in-house assay met our objective of improving blood safety at nominal cost and showed that it is feasible to set up small molecular biology units in medium-large sized blood banks and deliver blood within 24-48 hours. The utility of NAT (NAT yield will vary based on the donor population, the type of serological test used, the nature of kit employed and the sensitivity of NAT test used. The limitations of our in-house MP-NAT consisted of stringent sample preparation requirements, with labor and time involved. The benefits of our MP-NAT were that it acted as a second level of check for ELISA tests, was relatively inexpensive compared to ID-NAT and did not need sophisticated equipment.

  4. Safety evaluation report related to operation of Fast Flux Test Facility. Supplement No. 1

    International Nuclear Information System (INIS)

    1979-05-01

    This supplement provides (1) the staff's evaluation of additional information received since issuance of the Safety Evaluation Report regarding previously identified uncompleted review items, (2) a discussion of comments made by the ACRS in its report of November 8, 1978, and (3) the staff's evaluation of additional or revised information related to new or old issues that have arisen since the issuance of the Safety Evaluation Report

  5. Safety evaluation of irradiated foods in China: A condensed report

    International Nuclear Information System (INIS)

    Yin, D.

    1989-01-01

    Eight trials, with 439 human volunteers who consumed irradiated foods including rice, potatoes, mushrooms, peanuts, and Chinese sausages, as well as diets composed of multiple irradiated foods (irradiated at dosages of 0.2 to 8 kGy) that accounted for 60-66% of the entire diet, were carried out for 2-3 months according to a unified protocol. No adverse effects on body weight, blood pressure, ECG, hematology, blood enzyme activities, serum lipids or blood or urine 17-hydroxycortisol contents and no chromosomal aberration of peripheral blood lymphocytes were found. It is especially worthwhile to note that there was no change in the polyploidy after consumption of irradiated diets. On the basis of these results and a comprehensive analysis of the physical and chemical characteristics of irradiated foods, temporary hygienic standards for irradiated rice, potatoes, onions, garlic, Chinese sausages, peanuts, and mushrooms were promulgated by the Chinese Ministry of Public Health

  6. Renal denervation beyond the bifurcation: The effect of distal ablation placement on safety and blood pressure.

    Science.gov (United States)

    Beeftink, Martine M A; Spiering, Wilko; De Jong, Mark R; Doevendans, Pieter A; Blankestijn, Peter J; Elvan, Arif; Heeg, Jan-Evert; Bots, Michiel L; Voskuil, Michiel

    2017-04-01

    Renal denervation may be more effective if performed distal in the renal artery because of smaller distances between the lumen and perivascular nerves. The authors reviewed the angiographic results of 97 patients and compared blood pressure reduction in relation to the location of the denervation. No significant differences in blood pressure reduction or complications were found between patient groups divided according to their spatial distribution of the ablations (proximal to the bifurcation in both arteries, distal to the bifurcation in one artery and distal in the other artery, or distal to the bifurcation in both arteries), but systolic ambulatory blood pressure reduction was significantly related to the number of distal ablations. No differences in adverse events were observed. In conclusion, we found no reason to believe that renal denervation distal to the bifurcation poses additional risks over the currently advised approach of proximal denervation, but improved efficacy remains to be conclusively established. ©2017 Wiley Periodicals, Inc.

  7. Evaluation of Motorcycle Safety in Kansas : Technical Summary

    Science.gov (United States)

    2012-01-01

    Over the past several years, motorcycle fatalities have increased at an alarming rate in the United States. Motorcycle safety issues in Kansas are no different from the national scenario. Accordingly, this study attempted to investigate motorcycle cr...

  8. Physicochemical, nutritive and safety evaluation of local cereal ...

    African Journals Online (AJOL)

    SARAH

    2014-11-30

    Nov 30, 2014 ... practices and good manufacturing processing should be considered. Such initiatives need to be carried amongst local cereal producers to help minimize food safety risk and ... potential for contamination and deterioration with.

  9. Evaluation of the Safety of the Taraklamp Male Circumcision Device ...

    African Journals Online (AJOL)

    SITWALA COMPUTERS

    an effective additional means of preventing transmission of the HIV virus from ... country and include: cultural tradition, pain, and safety, as ... effective. Thus, the World Health Organization (WHO) has ..... systematic review and meta-analysis.

  10. Minnesota urban partnership agreement national evaluation : safety data test plan.

    Science.gov (United States)

    2009-11-17

    This report provides the safety data test plan for the Minnesota Urban Partnership Agreement (UPA) under the United States Department of Transportation (U.S. DOT) UPA Program. The Minnesota UPA projects focus on reducing congestion by employing strat...

  11. Safety evaluation for the inner canister closure station

    International Nuclear Information System (INIS)

    Glasscock, J.R.

    1987-01-01

    The Inner Canister Closure Station (ICCS), built by Remote Technology Corporation, will be operability tested. The ICCS is used to remotely leak test Inner Canister Closures (ICC's) and replace ICC's that are not water tight. After operability testing, the ICCS will be inspected and sent to the 717-F mock-up shop for remotability demonstration and dimensional checks, then installed in the Vitrification Building, 221-S. An analysis of potential safety hazards, equipment safety features, and procedural controls indicates that the ICCS can be operated without undue hazard to employees or to the public. A safety inspection and a new equipment inspection will be held before operation to verify that the ICCS meets Savannah River Site safety requirements. 4 refs., 6 figs

  12. Safety Analysis For Evaluating (SAFE) sUAS, Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — The primary goal of Air Traffic Management systems is to ensure safety of operations, in the air and on the ground. While they system have served the National...

  13. Quality and safety evaluation of a Ghanaian polyherbal product EAF ...

    African Journals Online (AJOL)

    McRoy

    means that issues concerning their quality, safety and efficacy need to be answered. In the current study, ... taken by several agencies like the World ..... this class of secondary metabolites detected ... during the manufacturing process as they.

  14. Evaluating software for safety systems in nuclear power plants

    International Nuclear Information System (INIS)

    Lawrence, J.D.; Persons, W.L.; Preckshot, G.G.; Gallagher, J.

    1994-01-01

    In 1991, LLNL was asked by the NRC to provide technical assistance in various aspects of computer technology that apply to computer-based reactor protection systems. This has involved the review of safety aspects of new reactor designs and the provision of technical advice on the use of computer technology in systems important to reactor safety. The latter includes determining and documenting state-of-the-art subjects that require regulatory involvement by the NRC because of their importance in the development and implementation of digital computer safety systems. These subjects include data communications, formal methods, testing, software hazards analysis, verification and validation, computer security, performance, software complexity and others. One topic software reliability and safety is the subject of this paper

  15. Planning and evaluation of plant under safety aspects

    International Nuclear Information System (INIS)

    Strnad, H.

    1985-01-01

    Plant denotes a technical product characterized as being structured, complex, comprising the use of energy, and that of measuring, automatic control and monitoring systems to keep track of present, control and monitor processes. Particular attention is paid to methods of developing plant concepts, measures to exclude or detect risks, integration of safety engineering into the course of planning, safety concept and ergonomics in plant design. (DG) [de

  16. ECORA - Evaluation of Computational Methods for Reactor Safety Analysis

    International Nuclear Information System (INIS)

    Scheuerer, Martina

    2002-01-01

    There were three motivations behind the ECORA Project: - the shortcomings of 0-D system codes in the simulation of 3-D, local flow and heat transfer phenomena, - increased interest in the application of 3-D CFD software as supplement to system codes, - high safety requirements in the nuclear industry required consistent standards for the use and assessment of CFD software. The purpose of ECORA was therefore: - to establish performance criteria for the assessment of CFD software, - to establish Best Practice Guidelines for application and use of CFD software, with the following objectives: - assessment of CFD applications in reactor safety: flows in containment (PANDA experiments) and flows in primary system (UPTF experiments) - Best Practice Guidelines for reactor safety: starting point (ERCOFTAC Best Practice Guidelines), adaptation to CFD application for nuclear safety, extension to assessment of experimental data - recommendations for improvements of CFD software, - network of European 'Centres of Competence for CFD Applications in Reactor Safety'. Currently, there were twelve partners in the ECORA Project, representing nine European countries. The Project was scheduled to last until September 2004. Ms Scheuerer then described the work programme and project structure, the Best Practice Guidelines for CFD simulations, the procedures for quantifying errors, applications of Best Practice Guidelines, Best Practice Guidelines for experimental data, applications to primary system, UPTF and PANDA data. Her conclusions were the following: - the Project had led to the improvement of the quality of CFD calculations in reactor safety, through: the ECORA Best Practice Guidelines, the assessment of shortcomings and the improvement of mathematical models. - It had also led to higher acceptance of CFD in reactor safety. - The next step was the establishment of European 'Centres of Competence for CFD Applications in reactor Safety'

  17. Restaurant supervisor safety training: evaluating a small business training intervention.

    Science.gov (United States)

    Bush, Diane; Paleo, Lyn; Baker, Robin; Dewey, Robin; Toktogonova, Nurgul; Cornelio, Deogracia

    2009-01-01

    We developed and assessed a program designed to help small business owners/managers conduct short training sessions with their employees, involve employees in identifying and addressing workplace hazards, and make workplace changes (including physical and work practice changes) to improve workplace safety. During 2006, in partnership with a major workers' compensation insurance carrier and a restaurant trade association, university-based trainers conducted workshops for more than 200 restaurant and food service owners/managers. Workshop participants completed posttests to assess their knowledge, attitudes, and intentions to implement health and safety changes. On-site follow-up interviews with 10 participants were conducted three to six months after the training to assess the extent to which program components were used and worksite changes were made. Post-training assessments demonstrated that attendees increased their understanding and commitment to health and safety, and felt prepared to provide health and safety training to their employees. Follow-up interviews indicated that participants incorporated core program concepts into their training and supervision practices. Participants conducted training, discussed workplace hazards and solutions with employees, and made changes in the workplace and work practices to improve workers' health and safety. This program demonstrated that owners of small businesses can adopt a philosophy of employee involvement in their health and safety programs if provided with simple, easy-to-use materials and a training demonstration. Attending a workshop where they can interact with other owners/ managers of small restaurants was also a key to the program's success.

  18. Introduction of Autonomous Vehicles: Roundabouts Design and Safety Performance Evaluation

    Directory of Open Access Journals (Sweden)

    Aleksandra Deluka Tibljaš

    2018-04-01

    Full Text Available Driving experiences provided by the introduction of new vehicle technologies are directly impacting the criteria for road network design. New criteria should be taken into consideration by designers, researchers and car owners in order to assure traffic safety in changed conditions that will appear with, for example, introduction of Autonomous Vehicles (AVs in everyday traffic. In this paper, roundabout safety level is analysed on the originally developed microsimulation model in circumstances where different numbers of AVs vehicles are mixed with Conventional Vehicles (CVs. Field data about speed and traffic volumes from existing roundabouts in Croatia were used for development of the model. The simulations done with the Surrogate Safety Assessment Model (SSAM give some relevant highlights on how the introduction of AVs could change both operational and safety parameters at roundabouts. To further explore the effects on safety of roundabouts with the introduction of different shares of AVs, hypothetical safety treatments could be tested to explore whether their effects may change, leading to the estimation of a new set of Crash Modification Factors.

  19. Meteorological events in site evaluation for nuclear power plants. Safety guide

    International Nuclear Information System (INIS)

    2005-01-01

    This Safety Guide provides recommendations and guidance on conducting hazard assessments of extreme and rare meteorological phenomena. It is of interest to safety assessors and regulators involved in the licensing process as well as to designers of nuclear power plants. This Safety Guide was prepared under the IAEA programme for safety standards for nuclear power plants. It supplements the IAEA Safety Requirements publication on Site Evaluation for Nuclear Facilities which is to supersede the Code on the Safety of Nuclear Power Plants: Siting, Safety Series No. 50-C-S (Rev. 1), IAEA, Vienna (1988). The present Safety Guide supersedes two earlier Safety Guides: Safety Series No. 50-SG-S11A (1981) on Extreme Meteorological Events in Nuclear Power Plant Siting, Excluding Tropical Cyclones and Safety Series No. 50-SG-S11B (1984) on Design Basis Tropical Cyclone for Nuclear Power Plants. The purpose of this Safety Guide is to provide recommendations and guidance on conducting hazard assessments of extreme and rare meteorological phenomena. This Safety Guide provides interpretation of the Safety Requirements publication on Site Evaluation for Nuclear Facilities and guidance on how to fulfil these requirements. It is aimed at safety assessors or regulators involved in the licensing process as well as designers of nuclear power plants, and provides them with guidance on the methods and procedures for analyses that support the assessment of the hazards associated with extreme and rare meteorological events. This Safety Guide discusses the extreme values of meteorological variables and rare meteorological phenomena, as well as their rates of occurrence, according to the following definitions: (a) Extreme values of meteorological variables such as air temperature and wind speed characterize the meteorological or climatological environment. And (b) Rare meteorological phenomena

  20. First-time whole blood donation: A critical step for donor safety and retention on first three donations.

    Science.gov (United States)

    Gillet, P; Rapaille, A; Benoît, A; Ceinos, M; Bertrand, O; de Bouyalsky, I; Govaerts, B; Lambermont, M

    2015-01-01

    Whole blood donation is generally safe although vasovagal reactions can occur (approximately 1%). Risk factors are well known and prevention measures are shown as efficient. This study evaluates the impact of the donor's retention in relation to the occurrence of vasovagal reaction for the first three blood donations. Our study of data collected over three years evaluated the impact of classical risk factors and provided a model including the best combination of covariates predicting VVR. The impact of a reaction at first donation on return rate and complication until the third donation was evaluated. Our data (523,471 donations) confirmed the classical risk factors (gender, age, donor status and relative blood volume). After stepwise variable selection, donor status, relative blood volume and their interaction were the only remaining covariates in the model. Of 33,279 first-time donors monitored over a period of at least 15 months, the first three donations were followed. Data emphasised the impact of complication at first donation. The return rate for a second donation was reduced and the risk of vasovagal reaction was increased at least until the third donation. First-time donation is a crucial step in the donors' career. Donors who experienced a reaction at their first donation have a lower return rate for a second donation and a higher risk of vasovagal reaction at least until the third donation. Prevention measures have to be processed to improve donor retention and provide blood banks with adequate blood supply. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  1. Evaluation model for safety capacity of chemical industrial park based on acceptable regional risk

    Institute of Scientific and Technical Information of China (English)

    Guohua Chen; Shukun Wang; Xiaoqun Tan

    2015-01-01

    The paper defines the Safety Capacity of Chemical Industrial Park (SCCIP) from the perspective of acceptable regional risk. For the purpose of exploring the evaluation model for the SCCIP, a method based on quantitative risk assessment was adopted for evaluating transport risk and to confirm reasonable safety transport capacity of chemical industrial park, and then by combining with the safety storage capacity, a SCCIP evaluation model was put forward. The SCCIP was decided by the smaller one between the largest safety storage capacity and the maximum safety transport capacity, or else, the regional risk of the park will exceed the acceptable level. The developed method was applied to a chemical industrial park in Guangdong province to obtain the maximum safety transport capacity and the SCCIP. The results can be realized in the regional risk control of the park effectively.

  2. Development of an Evaluation Method for Team Safety Culture Competencies using Social Network Analysis

    International Nuclear Information System (INIS)

    Han, Sang Min; Kim, Ar Ryum; Seong, Poong Hyun

    2016-01-01

    In this study, team safety culture competency of a team was estimated through SNA, as a team safety culture index. To overcome the limit of existing safety culture evaluation methods, the concept of competency and SNA were adopted. To estimate team safety culture competency, we defined the definition, range and goal of team safety culture competencies. Derivation of core team safety culture competencies is performed and its behavioral characteristics were derived for each safety culture competency, from the procedures used in NPPs and existing criteria to assess safety culture. Then observation was chosen as a method to provide the input data for the SNA matrix of team members versus insufficient team safety culture competencies. Then through matrix operation, the matrix was converted into the two meaningful values, which are density of team members and degree centralities of each team safety culture competency. Density of tem members and degree centrality of each team safety culture competency represent the team safety culture index and the priority of team safety culture competency to be improved

  3. Development of an Evaluation Method for Team Safety Culture Competencies using Social Network Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Min; Kim, Ar Ryum; Seong, Poong Hyun [KAIST, Daejeon (Korea, Republic of)

    2016-05-15

    In this study, team safety culture competency of a team was estimated through SNA, as a team safety culture index. To overcome the limit of existing safety culture evaluation methods, the concept of competency and SNA were adopted. To estimate team safety culture competency, we defined the definition, range and goal of team safety culture competencies. Derivation of core team safety culture competencies is performed and its behavioral characteristics were derived for each safety culture competency, from the procedures used in NPPs and existing criteria to assess safety culture. Then observation was chosen as a method to provide the input data for the SNA matrix of team members versus insufficient team safety culture competencies. Then through matrix operation, the matrix was converted into the two meaningful values, which are density of team members and degree centralities of each team safety culture competency. Density of tem members and degree centrality of each team safety culture competency represent the team safety culture index and the priority of team safety culture competency to be improved.

  4. Report of the evaluation by the Ad Hoc Review Committee on Nuclear Safety Research. Result evaluation in fiscal year 2000

    International Nuclear Information System (INIS)

    2001-06-01

    The Research Evaluation Committee, which consisted of 14 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Nuclear Safety Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the R and D accomplishments achieved for five years from Fiscal Year 1995 to Fiscal Year 1999 at Department of Reactor Safety Research, Department of Fuel Cycle Safety Research, Department of Environmental Safety Research and Department of Safety Research Technical Support in Tokai Research Establishment at JAERI. The Ad Hoc Review Committee consisted of 11 specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from December 2000 to February 2001. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on December 11, 2000, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on March 16, 2001. This report describes the result of the evaluation by the Ad Hoc Review Committee on Nuclear Safety Research. (author)

  5. Report of the evaluation by the Ad Hoc Review Committee on Nuclear Safety Research. Result evaluation in fiscal year 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2001-06-01

    The Research Evaluation Committee, which consisted of 14 members from outside of the Japan Atomic Energy Research Institute (JAERI), set up an Ad Hoc Review Committee on Nuclear Safety Research in accordance with the Fundamental Guideline for the Evaluation of Research and Development (R and D) at JAERI' and its subsidiary regulations in order to evaluate the R and D accomplishments achieved for five years from Fiscal Year 1995 to Fiscal Year 1999 at Department of Reactor Safety Research, Department of Fuel Cycle Safety Research, Department of Environmental Safety Research and Department of Safety Research Technical Support in Tokai Research Establishment at JAERI. The Ad Hoc Review Committee consisted of 11 specialists from outside of JAERI. The Ad Hoc Review Committee conducted its activities from December 2000 to February 2001. The evaluation was performed on the basis of the materials submitted in advance and of the oral presentations made at the Ad Hoc Review Committee meeting which was held on December 11, 2000, in line with the items, viewpoints, and criteria for the evaluation specified by the Research Evaluation Committee. The result of the evaluation by the Ad Hoc Review Committee was submitted to the Research Evaluation Committee, and was judged to be appropriate at its meeting held on March 16, 2001. This report describes the result of the evaluation by the Ad Hoc Review Committee on Nuclear Safety Research. (author)

  6. A Public-Private Consortium Advances Cardiac Safety Evaluation: Achievements of the HESI Cardiac Safety Technical Committee

    Science.gov (United States)

    The evaluation of cardiovascular side-effects is a critical element in the development of all new drugs and chemicals. Cardiac safety issues have been and continue to be a major cause of attrition and withdrawal due to Adverse Drug Reactions (ADRs) in pharmaceutical drug developm...

  7. Development of safety evaluation methods applied to the safety regulations for the operation stage of fast breeder reactor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The purposes of this study is to establish the safety evaluation methods needed in the operation stage of fast breeder reactor (FBR). Related the above purpose of this study, some investigation studies for the technical standard applied to Monju were achieved in JFY 2012. (author)

  8. 75 FR 71444 - Renewal of Charter for the Advisory Committee on Blood Safety and Availability

    Science.gov (United States)

    2010-11-23

    ... FURTHER INFORMATION CONTACT: Jerry Holmberg, PhD; Senior Advisor for Blood Policy and Executive Secretary... provides advice and guidance to the Secretary, through the Assistant Secretary for Health, on a range of... advice and guidance includes, but is not limited to: (1) Definition of public health parameters around...

  9. Renal denervation beyond the bifurcation : The effect of distal ablation placement on safety and blood pressure

    NARCIS (Netherlands)

    Beeftink, Martine M A; Spiering, Wilko; De Jong, Mark R.; Doevendans, Pieter A.; Blankestijn, Peter J.; Elvan, Arif; Heeg, Jan Evert; Bots, Michiel L.; Voskuil, Michiel

    2017-01-01

    Renal denervation may be more effective if performed distal in the renal artery because of smaller distances between the lumen and perivascular nerves. The authors reviewed the angiographic results of 97 patients and compared blood pressure reduction in relation to the location of the denervation.

  10. Health economics and outcomes methods in risk-based decision-making for blood safety

    NARCIS (Netherlands)

    Custer, Brian; Janssen, Mart P.

    2015-01-01

    Analytical methods appropriate for health economic assessments of transfusion safety interventions have not previously been described in ways that facilitate their use. Within the context of risk-based decision-making (RBDM), health economics can be important for optimizing decisions among competing

  11. Mochovce NPP safety measures evaluation from point of view of operational safety enhancement

    International Nuclear Information System (INIS)

    Cillik, I.; Vrtik, L.

    2000-01-01

    Mochovce NPP consists of four reactor units of WWER 440/V213 type and it is located in the south-middle part of Slovakia. At present first unit operated and the second one under the construction finishing. As these units represent second generation of WWER reactor design, the additional safety measures (SM) were implemented to enhance operational and nuclear safety according to the recommendations of performed international audits and operational experience based on exploitation of other similar units (as Dukovany and J. Bohunice NPPs). These requirements result into a number of SMs grouped according to their purpose to reach recent international requirements on nuclear and operational safety. The paper presents the bases used for safety measures establishing including their grouping into the comprehensive tasks covering different areas of safety goals as well as structural organization of a project management of including participating companies and work performance. More, results are given regarding contribution of selected SMs to the total core damage frequency decreasing. (author)

  12. PSA analysis focused on Mochovce NPP safety measures evaluation from operational safety point of view

    International Nuclear Information System (INIS)

    Cillik, I.; Vrtik, L.

    2001-01-01

    Mochovce NPP consists of four reactor units of WWER 440/V213 type and it is located in the south-middle part of Slovakia. At present first unit operated and the second one under the construction finishing. As these units represent second generation of WWER reactor design, the additional safety measures (SM) were implemented to enhance operational and nuclear safety according to the recommendations of performed international audits and operational experience based on exploitation of other similar units (as Dukovany and J. Bohunice NPPs). These requirements result into a number of SMs grouped according to their purpose to reach recent international requirements on nuclear and operational safety. The paper presents the bases used for safety measures establishing including their grouping into the comprehensive tasks covering different areas of safety goals as well as structural organization of a project management of including participating companies and work performance. More, results are given regarding contribution of selected SMs to the total core damage frequency decreasing.(author)

  13. Safety

    International Nuclear Information System (INIS)

    2001-01-01

    This annual report of the Senior Inspector for the Nuclear Safety, analyses the nuclear safety at EDF for the year 1999 and proposes twelve subjects of consideration to progress. Five technical documents are also provided and discussed concerning the nuclear power plants maintenance and safety (thermal fatigue, vibration fatigue, assisted control and instrumentation of the N4 bearing, 1300 MW reactors containment and time of life of power plants). (A.L.B.)

  14. Periodic safety re-evaluations in NPPs in EC member states, Finland and Sweden

    International Nuclear Information System (INIS)

    1990-01-01

    The work on periodic safety re-evaluations summarized in this report was performed by a Task Force of the CEC Working Group on the Safety of Thermal Reactors. The periodic safety re-evaluations under review in this study were those that are carried out in addition to other reviews which represent the primary means of safety assurance. The periodic safety re-evaluation is broader and more comprehensive in nature. The cumulative effects of experience (national and international), advances in knowledge and analysis techniques, improvements in safety standards and operating practices, overall effects of plant ageing, and the totality of all modifications over the period in question need to be taken into account. All countries have recognized the value of such periodic reviews, and licensees, either as a regulatory requirement or as a voluntary action, are carrying them out. The scope and contents of each country's review showed many similarities of approach, any differences being explained by the age and type of reactor in operation. Many similarities emerged in the topics selected for re-evaluation and in the approach to re-evaluation itself. The overall conclusion was that while approaches may differ in some respects, for practical purposes comparable levels of safety are achieved in the periodic safety re-evaluation of nuclear power plants

  15. Evaluation of behaviour and Safety in a geologic deep repository

    International Nuclear Information System (INIS)

    1997-01-01

    This report presents a comprehensive description of the post-closure radiological safety assessment of a repository for the spent fuel arisings resulting from the Spanish nuclear program. This Safety Assessment constitutes a first step within a systematical process that will permit, thorough successive approximations, to predict the performance of the different barriers of the disposal system, and its capability to comply with the assigned safety functions and with the established safety criteria. The primary bases for this Safety Assessment are the following: The disposal concept considers the storage of the fuel assemblies in carbon steel canisters of 10 cm of thickness, emplaced horizontally in galleries excavated in granite of 2,4 m of diameter and 500 m of length, using a bentonite thickness of 75 cm around canisters as buffer material. The repository is located in a granitic site defined with available data about surface characteristics of Spanish granites. The exercise uses a probabilistic approximation in order to cope with the uncertainties associated with the different imputs parameters. (Author)

  16. Application of Mixed Group Decision Making to Safety Evaluation of Agricultural Products

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    In view of the gravity of issues concerning safety of agricultural products and urgency of resolving these issues,after analyzing the problems existing in safety of agricultural products,this article offers a method for evaluating safety of agricultural products on the basis of mixed group decision making.First of all,it introduces the factors influencing safety evaluation of agricultural products;subsequently,given that the judgment matrices offered by the group of experts contain both reciprocal and complementary judgment matrices in the process of jointly participating in evaluation arising from personal preference,it proposes to assemble expert information in order to obtain indicator weight using the OWA operator;finally,the process of evaluating safety of agricultural products is given.

  17. An evaluation of a supplementary road safety package.

    Science.gov (United States)

    Guria, Jagadish; Leung, Joanne

    2004-09-01

    A Supplementary Road Safety Package (SRSP) was developed in New Zealand in 1995/1996 to supplement the compulsory breath test (CBT) and speed camera programmes introduced in 1993. A major feature of the package was the use of emotion and shock advertising campaigns not only to affect high risk driving attitudes and behaviours towards speeding and drink-driving but also to encourage the use of safety belts. Furthermore, the SRSP also emphasised targeting enforcement to these three areas. This package continued for 5 years. This paper estimates the effect of the package on road trauma. The analysis shows that the Package made substantial impact on road safety and saved over 285 lives over the 5-year period. Copyright 2003 Elsevier Ltd.

  18. Study on Fuzzy Comprehensive Evaluation Model for the Safety of Mine Belt Conveyor

    Directory of Open Access Journals (Sweden)

    Gong Xiaoyan

    2017-01-01

    Full Text Available To improve the situation of the frequent failures of mine belt conveyor during operation, a model was used to evaluate the safety of mine belt conveyor. Based on the foundation of collecting and analyzing a large quantity of fault information of belt conveyor in the nationwide coal mine, the fault tree model of belt conveyor has been built, then the safety evaluation index system was established by analyzing and removing some secondary indicators. Furthermore, the weighted value of safety evaluation indexs was determined by analytic hierarchy process(AHP, and the single factor fuzzy evaluation matrix was constructed by experts grading method. Additionally, the model was applied in evaluating the security of belt conveyor in Nanliang coal mine. The results shows the security level is recognized to the “general”, which means that this model can be adopted widely in evaluating the safety of mine belt conveyor.

  19. Research on Evaluation Model for Secondary Task Driving Safety Based on Driver Eye Movements

    Directory of Open Access Journals (Sweden)

    Lisheng Jin

    2014-01-01

    Full Text Available This study was designed to gain insight into the influence of performing different types of secondary task while driving on driver eye movements and to build a safety evaluation model for secondary task driving. Eighteen young drivers were selected and completed the driving experiment on a driving simulator. Measures of fixations, saccades, and blinks were analyzed. Based on measures which had significant difference between the baseline and secondary tasks driving conditions, the evaluation index system was built. Method of principal component analysis (PCA was applied to analyze evaluation indexes data in order to obtain the coefficient weights of indexes and build the safety evaluation model. Based on evaluation scores, the driving safety was grouped into five levels (very high, high, average, low, and very low using K-means clustering algorithm. Results showed that secondary task driving severely distracts the driver and the evaluation model built in this study could estimate driving safety effectively under different driving conditions.

  20. Evaluation of patient safety culture among Malaysian retail pharmacists: results of a self-reported survey.

    Science.gov (United States)

    Sivanandy, Palanisamy; Maharajan, Mari Kannan; Rajiah, Kingston; Wei, Tan Tyng; Loon, Tan Wee; Yee, Lim Chong

    2016-01-01

    Patient safety is a major public health issue, and the knowledge, skills, and experience of health professionals are very much essential for improving patient safety. Patient safety and medication error are very much associated. Pharmacists play a significant role in patient safety. The function of pharmacists in the medication use process is very different from medical and nursing colleagues. Medication dispensing accuracy is a vital element to ensure the safety and quality of medication use. To evaluate the attitude and perception of the pharmacist toward patient safety in retail pharmacies setup in Malaysia. A Pharmacy Survey on Patient Safety Culture questionnaire was used to assess patient safety culture, developed by the Agency for Healthcare Research and Quality, and the convenience sampling method was adopted. The overall positive response rate ranged from 31.20% to 87.43%, and the average positive response rate was found to be 67%. Among all the eleven domains pertaining to patient safety culture, the scores of "staff training and skills" were less. Communication openness, and patient counseling are common, but not practiced regularly in the Malaysian retail pharmacy setup compared with those in USA. The overall perception of patient safety of an acceptable level in the current retail pharmacy setup. The study revealed that staff training, skills, communication in patient counseling, and communication across shifts and about mistakes are less in current retail pharmacy setup. The overall perception of patient safety should be improved by educating the pharmacists about the significance and essential of patient safety.

  1. Evaluation of Influence Factors within Implementing of Nuclear Safety Culture in Embarking Countries

    International Nuclear Information System (INIS)

    Situmorang, J.

    2016-01-01

    The evaluation of the implementation nuclear safety culture at BATAN has been performed. BATAN is Indonesia’s national nuclear energy agency. Nowadays, BATAN is planning to develop an experimental power reactor. To implement the nuclear safety culture BATAN has issued BATAN chairman regulation (Perka BATAN 200). Perka BATAN is the reference for individuals and organizations to implement nuclear safety culture which includes basic principles, mechanisms, assessment, as well as the implementation of the application of safety culture. It covers the establishment of safety policies, program development, program implementation, development and measurement of safety culture. Each facilities within BATAN is expected to well implement a safety culture. The implementation of safety culture is developed by considering the characteristics, attributes and indicators. The characteristics, attributes and indicators referenced are elaborated from the IAEA. The activities to strengthen safety culture are monthly workshop with participants is head of every facilities, safety leadership training and workshop for safety division manager in every facilities. It is also issued a handbook of safety that is distributed to all employees BATAN.

  2. Evaluation of safety, an unavoidable requirement in the applications of ionizing radiations

    International Nuclear Information System (INIS)

    Jova Sed, Luis Andres

    2013-01-01

    The safety assessments should be conducted as a means to evaluate compliance with safety requirements (and thus the application of fundamental safety principles) for all facilities and activities in order to determine the measures to be taken to ensure safety. It is an essential tool in decision making. For long time we have linked the safety assessment to nuclear facilities and not to all practices involving the use of ionizing radiation in daily life. However, the main purpose of the safety assessment is to determine if it has reached an appropriate level of safety for an installation or activity and if it has fulfilled the objectives of safety and basic safety criteria set by the designer, operating organization and the regulatory body under the protection and safety requirements set out in the International Basic safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources. This paper presents some criteria and personal experiences with the new international recommendations on this subject and its practical application in the region and demonstrates the importance of this requirement. Reflects the need to train personnel of the operator and the regulatory body in the proportional application of this requirement in practice with ionizing radiation

  3. Structural evaluation of safety class components to natural phenomena loadings

    International Nuclear Information System (INIS)

    Conrads, T.J.

    1989-01-01

    This paper addresses the efforts completed at the US Department of Energy Hanford Site near Richland, Washington, to qualify structurally a number of existing safety class components in the Plutonium Finishing Plant complex. Design, fabrication, and installation of the facility occurred in the 1950s and 1960s and were based on the Uniform Building Code criteria for wind and earthquake loads. Recently the buildings were qualified to site-specific wind and seismic hazards. The methodology employed to qualify seismically the safety class components is discussed

  4. Evaluation of food safety management systems in Serbian dairy industry

    Directory of Open Access Journals (Sweden)

    Igor Tomašević

    2016-01-01

    Full Text Available This paper reports incentives, costs, difficulties and benefits of food safety management systems implementation in the Serbian dairy industry. The survey involved 27 food business operators with the national milk and dairy market share of 65 %. Almost two thirds of the assessed dairy producers (70.4 % claimed that they had a fully operational and certified HACCP system in place, while 29.6 % implemented HACCP, but had no third party certification. ISO 22000 was implemented and certified in 29.6 % of the companies, while only 11.1 % had implemented and certified IFS standard. The most important incentive for implementing food safety management systems for Serbian dairy producers was to increase and improve safety and quality of dairy products. The cost of product investigation/analysis and hiring external consultants were related to the initial set-up of food safety management system with the greatest importance. Serbian dairy industry was not greatly concerned by the financial side of implementing food safety management systems due to the fact that majority of prerequisite programmes were in place and regularly used by almost 100 % of the producers surveyed. The presence of competency gap between the generic knowledge for manufacturing food products and the knowledge necessary to develop and implement food safety management systems was confirmed, despite the fact that 58.8 % of Serbian dairy managers had university level of education. Our study brings about the innovation emphasizing the attitudes and the motivation of the food production staff as the most important barrier for the development and implementation of HACCP. The most important identified benefit was increased safety of dairy products with the mean rank scores of 6.85. The increased customer confidence and working discipline of staff employed in food processing were also found as important benefits of implementing/operating HACCP. The study shows that the level of HACCP

  5. Development of main steam safety valve set pressure evaluating system

    International Nuclear Information System (INIS)

    Oketani, Koichiro; Manabe, Yoshihisa.

    1991-01-01

    A main steam safety valve set pressure test is conducted for all valves during every refueling outage in Japan's PWRs. Almost all operations of the test are manually conducted by a skilled worker. In order to obtain further reliability and reduce the test time, an automatic test system using a personnel computer has been developed in accordance with system concept. Quality assurance was investigated to fix system specifications. The prototype of the system was manufactured to confirm the system reliability. The results revealed that this system had high accuracy measurement and no adverse influence on the safety valve. This system was concluded to be applicable for actual use. (author)

  6. Critical evaluation of nuclear safety reports Pt. 1

    International Nuclear Information System (INIS)

    Egely, Gy.

    1987-01-01

    Licensing procedures of siting, commissioning and operation of nuclear power plants in the USA, FRG, France and Japan are compared. The standard format and content of nuclear safety analysis reports including the general description of the plant, the presentation of the characteristics of siting, building structures, components, facilities, the reactors, the cooling system, the safety system, the measuring and control system, the power supply system, the auxilliary system, the energy transformation system, etc. are discussed in detail by the example of the US procedure. (V.N.)

  7. Occupational health and safety: Designing and building with MACBETH a value risk-matrix for evaluating health and safety risks

    Science.gov (United States)

    Lopes, D. F.; Oliveira, M. D.; Costa, C. A. Bana e.

    2015-05-01

    Risk matrices (RMs) are commonly used to evaluate health and safety risks. Nonetheless, they violate some theoretical principles that compromise their feasibility and use. This study describes how multiple criteria decision analysis methods have been used to improve the design and the deployment of RMs to evaluate health and safety risks at the Occupational Health and Safety Unit (OHSU) of the Regional Health Administration of Lisbon and Tagus Valley. ‘Value risk-matrices’ (VRMs) are built with the MACBETH approach in four modelling steps: a) structuring risk impacts, involving the construction of descriptors of impact that link risk events with health impacts and are informed by scientific evidence; b) generating a value measurement scale of risk impacts, by applying the MACBETH-Choquet procedure; c) building a system for eliciting subjective probabilities that makes use of a numerical probability scale that was constructed with MACBETH qualitative judgments on likelihood; d) and defining a classification colouring scheme for the VRM. A VRM built with OHSU members was implemented in a decision support system which will be used by OHSU members to evaluate health and safety risks and to identify risk mitigation actions.

  8. Climate change projections of West Nile virus infections in Europe: implications for blood safety practices.

    Science.gov (United States)

    Semenza, Jan C; Tran, Annelise; Espinosa, Laura; Sudre, Bertrand; Domanovic, Dragoslav; Paz, Shlomit

    2016-03-08

    West Nile virus (WNV) is transmitted by mosquitoes in both urban as well as in rural environments and can be pathogenic in birds, horses and humans. Extrinsic factors such as temperature and land use are determinants of WNV outbreaks in Europe, along with intrinsic factors of the vector and virus. With a multivariate model for WNV transmission we computed the probability of WNV infection in 2014, with July 2014 temperature anomalies. We applied the July temperature anomalies under the balanced A1B climate change scenario (mix of all energy sources, fossil and non-fossil) for 2025 and 2050 to model and project the risk of WNV infection in the future. Since asymptomatic infections are common in humans (which can result in the contamination of the donated blood) we estimated the predictive prevalence of WNV infections in the blood donor population. External validation of the probability model with 2014 cases indicated good prediction, based on an Area Under Curve (AUC) of 0.871 (SD = 0.032), on the Receiver Operating Characteristic Curve (ROC). The climate change projections for 2025 reveal a higher probability of WNV infection particularly at the edges of the current transmission areas (for example in Eastern Croatia, Northeastern and Northwestern Turkey) and an even further expansion in 2050. The prevalence of infection in (blood donor) populations in the outbreak-affected districts is expected to expand in the future. Predictive modelling of environmental and climatic drivers of WNV can be a valuable tool for public health practice. It can help delineate districts at risk for future transmission. These areas can be subjected to integrated disease and vector surveillance, outreach to the public and health care providers, implementation of personal protective measures, screening of blood donors, and vector abatement activities.

  9. Scale development of safety management system evaluation for the airline industry.

    Science.gov (United States)

    Chen, Ching-Fu; Chen, Shu-Chuan

    2012-07-01

    The airline industry relies on the implementation of Safety Management System (SMS) to integrate safety policies and augment safety performance at both organizational and individual levels. Although there are various degrees of SMS implementation in practice, a comprehensive scale measuring the essential dimensions of SMS is still lacking. This paper thus aims to develop an SMS measurement scale from the perspective of aviation experts and airline managers to evaluate the performance of company's safety management system, by adopting Schwab's (1980) three-stage scale development procedure. The results reveal a five-factor structure consisting of 23 items. The five factors include documentation and commands, safety promotion and training, executive management commitment, emergency preparedness and response plan and safety management policy. The implications of this SMS evaluation scale for practitioners and future research are discussed. Copyright © 2012 Elsevier Ltd. All rights reserved.

  10. Scintigraphic method for evaluating reductions in local blood volumes in human extremities

    DEFF Research Database (Denmark)

    Blønd, L; Madsen, Jan Lysgård

    2000-01-01

    in the experiment. Evaluation of one versus two scintigraphic projections, trials for assessment of the reproducibility, a comparison of the scintigraphic method with a water-plethysmographic method and registration of the fractional reduction in blood volume caused by exsanguination as a result of simple elevation......% in the lower limb experiment and 6% in the upper limb experiment. We found a significant relation (r = 0.42, p = 0.018) between the results obtained by the scintigraphic method and the plethysmographic method. In fractions, a mean reduction in blood volume of 0.49+0.14 (2 SD) was found after 1 min of elevation......We introduce a new method for evaluating reductions in local blood volumes in extremities, based on the combined use of autologue injection of 99mTc-radiolabelled erythrocytes and clamping of the limb blood flow by the use of a tourniquet. Twenty-two healthy male volunteers participated...

  11. Evaluation of Blood Hemodynamics in Vascular Grafts after Total Arterial Coronary Revascularization

    Directory of Open Access Journals (Sweden)

    Ahmad Ali Amirghofran

    2016-07-01

    Full Text Available Arterial grafting has increasingly been advocated for the treatment of coronary artery disease in an attempt to improve the long-term results. In the quest to perform routine total arterial revascularization, composite Y graft methods are gaining popularity. The aim of our study was to evaluate whether blood flow in the left internal thoracic artery can provide sufficient perfusion to the entire cardiac muscle per se. Twenty patients with severe coronary artery stenosis who underwent complete arterial coronary revascularization using a composite graft entered our study. Blood flow in thoracic trunk was evaluated in three phases: cross-clamp on, cross-clamp off, and after weaning the patient from cardiopulmonary bypass. Mean arterial blood pressure in the thoracic trunk in these various positions was 62.7±3.7. left internal thora cic artery can provide sufficient blood flow to the cardiac muscles for both rest and exercise conditions.

  12. Evaluative threat and ambulatory blood pressure: cardiovascular effects of social stress in daily experience.

    Science.gov (United States)

    Smith, Timothy W; Birmingham, Wendy; Uchino, Bert N

    2012-11-01

    Physiological effects of social evaluation are central in models of psychosocial influences on physical health. Experimental manipulations of evaluative threat evoke substantial cardiovascular and neuroendocrine responses in laboratory studies, but only preliminary evidence is available regarding naturally occurring evaluative threats in daily life. In such nonexperimental ambulatory studies, it is essential to distinguish effects of evaluative threat from related constructs known to alter stress, such as ability perceptions and concerns about appearance. 94 married, working couples (mean age 29.2 years) completed a 1-day (8 a.m. to 10 p.m.) ambulatory blood pressure protocol with random interval-contingent measurements using a Suntech monitor and Palm Pilot-based measures of control variables and momentary experiences of social-evaluative threat, concerns about appearance, and perceived ability. In hierarchical analyses for couples and multiple measurement occasions (Proc Mixed; SAS) and controlling individual differences (BMI, age, income) and potential confounds (e.g., posture, activity), higher reports of social-evaluative threat were associated with higher concurrent systolic (estimate = .87, SE = .34) and diastolic blood pressure (estimate = 1.06; SE = .26), both p social-evaluative threat remained significant when perceived ability and appearance concerns were controlled. Naturally occurring social-evaluative threat during daily activity is associated with increased systolic and diastolic blood pressure. Given associations between ambulatory blood pressure and risk of cardiovascular disease, the findings support conceptual models of threats to the social self as a potentially important influence on physical health.

  13. Development of safety evaluation methods and analysis codes applied to the safety regulations for the design and construction stage of fast breeder reactor

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2013-08-15

    The purposes of this study are to develop the safety evaluation methods and analysis codes needed in the design and construction stage of fast breeder reactor (FBR). In JFY 2012, the following results are obtained. As for the development of safety evaluation methods needed in the safety examination conducted for the reactor establishment permission, development of the analysis codes, such as core damage analysis code, were carried out following the planned schedule. As for the development of the safety evaluation method needed for the risk informed safety regulation, the quantification technique of the event tree using the Continuous Markov chain Monte Carlo method (CMMC method) were studied. (author)

  14. Safety Evaluation of Osun River Water Containing Heavy Metals and ...

    African Journals Online (AJOL)

    olayemitoyin

    Cancers, respiratory diseases, organ failures .... acclimatized at 25±6oC with day and night cycle of 12 h each for ... Haematological Indices Analysis: White Blood cells. (WBC), red ..... It keeps up the cellular levels of active forms of vitamins C ...

  15. Safety evaluation of neem (Azadirachta indica) derived pesticides

    NARCIS (Netherlands)

    Boeke, S.J.; Boersma, M.G.; Alink, G.M.; Loon, van J.J.A.; Huis, van A.; Dicke, M.; Rietjens, I.M.C.M.

    2004-01-01

    The neem tree, Azadirachta indica, provides many useful compounds that are used as pesticides and could be applied to protect stored seeds against insects. However in addition to possible beneficial health effects, such as blood sugar lowering properties, anti-parasitic, anti-inflammatory,

  16. Treatment options for nonalcoholic steatohepatitis - a safety evaluation.

    Science.gov (United States)

    Issa, Danny; Wattacheril, Julia; Sanyal, Arun J

    2017-08-01

    There is an urgent as yet unmet need to develop highly effective and safe therapeutics for nonalcoholic fatty liver disease (NAFLD). The remarkable progress in understanding NAFLD pathogenesis allowed the identification of injury pathways which may be recruited as therapy targets. Areas covered: This article reviews the safety and tolerability data of the NAFLD therapies and explains the mechanistic basis for each of the established and investigational drugs. Treatment targets include: weight loss, anti-metabolic agents such as lipid lowering and anti-diabetic drugs, inflammation, fibrosis and others such as targeting gut microbiota, immune modulation and apoptosis. Expert opinion: Current therapies continue to remain suboptimal. Weight loss is effective but hard to achieve. Traditional and endoscopic bariatric procedures are promising although more randomized trials are needed and the long-term safety remains to be established. Clinical trials have demonstrated the efficacy of several drugs for the treatment of NASH. Of these, there remains some uncertainty about the long-term safety of vitamin E. Pioglitazone is associated with osteopenia, fluid retention and weight gain. Obeticholic acid causes pruritus in a substantial proportion of subjects and elafibranor has been associated with transient rises in creatinine. Several exciting therapies are under development and results of clinical and post-marketing trials will help elucidate their safety.

  17. Risk allocation approach to reactor safety design and evaluation

    International Nuclear Information System (INIS)

    Gokcek, O.; Temme, M.I.; Derby, S.L.

    1978-01-01

    This paper describes a risk allocation technique used for determining nuclear power plant design reliability requirements. The concept of risk allocation-optimum choice of safety function reliabilities under a maximum risk constraint - is described. An example of risk allocation is presented to demonstrate the application of the methodology

  18. Quality and safety evaluation of a Ghanaian polyherbal product EAF ...

    African Journals Online (AJOL)

    Background: The widespread use of herbal medicines in recent years means that issues concerning their quality, safety and efficacy need to be answered. In the current study, the polyherbal formulation EAF-2011 used in the Centre for Scientific Research into Plant Medicine, Mampong- Akwapemfor the management of ...

  19. Evaluation of safety in the transportation of natural uranium hexafluoride

    International Nuclear Information System (INIS)

    Maitre, P.; Meslin, T.; Pages, P.

    A general model developed for the safety of transporting radioactive materials is applied to UF 6 . Results given concern only the container contents during an accident; harmful consequences to the environment are not considered. It is shown that railroad transport is safer than road transport, particularly with regard to fire. 13 figs., 12 tables

  20. Economic evaluation of safety measures for transport companies

    NARCIS (Netherlands)

    Rietveld, Piet; Rienstra, Sytze A.

    1998-01-01

    Measures to reduce material damage within companies may both increase the business economic performance of the company and traffic safety in general. In this paper the notion of whether such measures are economically feasible is investigated. Results are presented of a series of interviews