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Sample records for european standard procedure

  1. The European Stroke Organisation Guidelines: a standard operating procedure

    DEFF Research Database (Denmark)

    Ntaios, George; Bornstein, Natan M; Caso, Valeria

    2015-01-01

    In 2008, the recently founded European Stroke Organisation published its guidelines for the management of ischemic stroke and transient ischemic attack. This highly cited document was translated in several languages and was updated in 2009. Since then, the European Stroke Organisation has published...... pace with this progress and driven by the strong determination of the European Stroke Organisation to further promote stroke management, education, and research, the European Stroke Organisation decided to delineate a detailed standard operating procedure for its guidelines. There are two important...... cornerstones in this standard operating procedure: The first is the implementation of the Grading of Recommendations Assessment, Development, and Evaluation methodology for the development of its Guideline Documents. The second one is the decision of the European Stroke Organisation to move from the classical...

  2. The European Stroke Organisation Guidelines: a standard operating procedure.

    Science.gov (United States)

    Ntaios, George; Bornstein, Natan M; Caso, Valeria; Christensen, Hanne; De Keyser, Jacques; Diener, Hans-Christoph; Diez-Tejedor, Exuperio; Ferro, Jose M; Ford, Gary A; Grau, Armin; Keller, Emanuella; Leys, Didier; Russell, David; Toni, Danilo; Turc, Guillaume; Van der Worp, Bart; Wahlgren, Nils; Steiner, Thorsten

    2015-10-01

    In 2008, the recently founded European Stroke Organisation published its guidelines for the management of ischemic stroke and transient ischemic attack. This highly cited document was translated in several languages and was updated in 2009. Since then, the European Stroke Organisation has published guidelines for the management of intracranial aneurysms and subarachnoidal hemorrhage, for the establishment of stroke units and stroke centers, and recently for the management of intracerebral hemorrhage. In recent years, the methodology for the development of guidelines has evolved significantly. To keep pace with this progress and driven by the strong determination of the European Stroke Organisation to further promote stroke management, education, and research, the European Stroke Organisation decided to delineate a detailed standard operating procedure for its guidelines. There are two important cornerstones in this standard operating procedure: The first is the implementation of the Grading of Recommendations Assessment, Development, and Evaluation methodology for the development of its Guideline Documents. The second one is the decision of the European Stroke Organisation to move from the classical model of a single Guideline Document about a major topic (e.g. management of ischemic stroke) to focused modules (i.e. subdivisions of a major topic). This will enable the European Stroke Organisation to react faster when new developments in a specific stroke field occur and update its recommendations on the related module rather swiftly; with the previous approach of a single large Guideline Document, its entire revision had to be completed before an updated publication, delaying the production of up-to-date guidelines. After discussion within the European Stroke Organisation Guidelines Committee and significant input from European Stroke Organisation members as well as methodologists and analysts, this document presents the official standard operating procedure for

  3. New Serbian criminal procedure: New reasons for harmonization with European legal standards

    Directory of Open Access Journals (Sweden)

    Đurđić Vojislav

    2014-01-01

    Full Text Available The new criminal procedure, set forth in 2011, represents a compilation of the inquisitive model of preliminary proceedings, on the one hand, and adversarial trial of the Anglo-American type of criminal procedure on the other. Introduction of the public prosecutor's investigation required a subtle legislative approach to the protection of human rights in criminal proceedings, in order to establish equilibrium between efficient and just procedure. Instead of the expected, the erroneous conception based on the ideas that the public prosecutor's investigation should be strictly formal as that of a court, that evidence taken by the non-judicial authorities should have the same bearing as those taken by the courts, and that the court should have no role in conducting investigation, resulted in an overly inferior position of the accuses compared to that of the public prosecutor. Beside the fact that such conception can not pass the ECJ test, the specific legal solutions referring the investigation open the question of harmonization with the European legal standards. The provisions on initiation of this phase of the proceedings, not being legally sanctioned, put in question the right of the accused to access justice, as well as his right to an effective legal remedy, and the introduced investigation against the unknown perpetrator, the right to be present at one's own trial is being jeopardized. Neither do all procedural rules pertaining to the trial support the fair procedure principle: the indirect extortion of evidence from the defense is discordant with the rule that the burden of proof lies on the prosecutor, as one of the main pillars of the assumption of innocence; as well as the broad opportunity to use non-judicial evidence at the hearing without any major legal obstacles, have demolished the principles of directness and contradictoriness. Even some of the minimal right of the defense as well as the guarantees of personal freedom in the course

  4. European standards for composite construction

    NARCIS (Netherlands)

    Stark, J.W.B.

    2000-01-01

    The European Standards Organisation (CEN) has planned to develop a complete set of harmonized European building standards. This set includes standards for composite steel and concrete buildings and bridges. The Eurocodes, being the design standards, form part of this total system of European

  5. Standardization and the European Standards Organisations

    Directory of Open Access Journals (Sweden)

    Marta Orviska

    2014-01-01

    Full Text Available Standardization is a relatively neglected aspect of the EU regulatory process and yet it is fundamental to that process and arguably has recently been the key vehicle in making the single market an economic reality. Yet the key standardization bodies in the EU, the ESOs, are scarcely known to the public and seldom discussed in the literature. In this article we redress this imbalance, arguing that standardization and integration are closely related concepts. We also argue that the ESOs have developed a degree of autonomy in expanding the boundaries of standardization and even in developing their own links with the rest of the world. Recent proposals put forward by the European Commission can be seen as an attempt to reduce that autonomy. These proposals emphasize the speed of, and stakeholder involvement in, standards production, which we further suggest are somewhat conflicting aims.

  6. European wind turbine procedure development blade test methods and techniques

    Energy Technology Data Exchange (ETDEWEB)

    Bulder, B.H.; Dam, J.J.D. van; Delft, D.R.V. van [and others

    1999-03-01

    In this paper the preliminary results obtained by performing the second task of the `European Wind Turbine Testing Procedure Development` project are presented. This project is performed within and with financial support of the Standards, Measurements and Testing programme of the European Commission. (au)

  7. Safety alarms and European standards

    CERN Document Server

    Nunes, R W

    1999-01-01

    This paper describes the current status and future of the safety-alarm (Alarm-of-Level-3) equipment at CERN. The emphasis is on the classification of these systems in the European standards framework as well as in other relevant international standards. Fire and gas detection systems and evacuation alarms represent the majority (approximately 90%) of the safety-alarm equipment at CERN. We will mainly address issues concerning the functioning of the fire-detection equipment and how it communicates with the Safety Control Room and Technical Control Room. The technological evolution of the equipment will be discussed. We shall also refer to the international and national standards applicable at CERN in the fire-equipment domain.

  8. Radiation control standards and procedures

    Energy Technology Data Exchange (ETDEWEB)

    1956-12-14

    This manual contains the Radiation Control Standards'' and Radiation Control Procedures'' at Hanford Operations which have been established to provide the necessary control radiation exposures within Irradiation Processing Department. Provision is also made for including, in the form of Bulletins'', other radiological information of general interest to IPD personnel. The purpose of the standards is to establish firm radiological limits within which the Irradiation Processing Department will operate, and to outline our radiation control program in sufficient detail to insure uniform and consistent application throughout all IPD facilities. Radiation Control Procedures are intended to prescribe the best method of accomplishing an objective within the limitations of the Radiation Control Standards. A procedure may be changed at any time provided the suggested changes is generally agreeable to management involved, and is consistent with department policies and the Radiation Control Standards.

  9. European wind turbine standards 2 (EWTS-2)

    Energy Technology Data Exchange (ETDEWEB)

    Pierik, J.T.G.; Dekker, J.W.M.; Braam, H. [and others

    1999-03-01

    A summary is given of the main results of the European Wind Turbine Standards II project. EWTS-II was completed in 1998 and included investigations on: 1) wind farms-wind field and turbine loading; 2) complex terrain and fatigue loading; 3) extreme wind conditions; 4) quantification of failure probabilities; 5) integration of blade tests in design; 6) power performance in complex terrain; 7) site evaluation. In addition to these scientific evaluations, the EWTS-II participants established an organization of qualified measuring institute in the field of wind energy, the MEASNET organization. MEASNET unified measurement procedures of the participating institutes and guarantees qualified measurements and mutual acceptance among its members. (LN)

  10. European wind turbine testing procedure developments. Task 2: Power quality

    DEFF Research Database (Denmark)

    Sørensen, Poul Ejnar; Friis Pedersen, Troels; Gerdes, G.

    2001-01-01

    quality measuremnet procedure in the Measnet cooperation of European test stations for wind turbines. The first working item of the project has been toverify the state of the art of the measurement procedures by analyses and comparisons of the measurements and data processing software of the participating......The present report describes the work done in the power quality subtask of the European Wind Turbine Testing Procedure Developments project funded by the EU SMT program. The objective of the power quality subtask has been to make recommendations andprovide background for new standards...... for measurement and testing of wind turbine power quality. The focus in the work has been to support the ongoing standardisation work in IEC with a new standard IEC61400-21 for measurement and assessment of powerquality characteristics of grid connected wind turbines. The work has also been based on the power...

  11. The European Procedure on Reduced Value Claims

    Directory of Open Access Journals (Sweden)

    Alexandrina Zaharia

    2009-06-01

    Full Text Available Maintaining and developing the area of freedom, security and justice is a major objective of theEuropean Community, which guarantees the free movement of persons. As a result of litigations regardingthe applications with a reduced value arising among physical or legal persons, it was felt the need for acommunity legislation that would guarantee identical conditions, both for creditors and debtors throughoutthe entire European Union territory. The European procedure regarding the debts recovery of reducedvalue facilitates the access to justice and it is characterized by simplifying and expediting the settling of thetransboundary litigations, reducing costs, the recognition and execution of the court order in a MemberState given in another Member State. This procedure is available to litigants as an alternative to theprocedures provided by the laws of Member States. The Regulation (EC no. 861/2007 establishing aEuropean procedure regarding the applications with reduced value applies in civil and commercial matters inthe transboundary cases, regardless the nature of the court when the application value, without taking intoaccount the interest, expenditures and other costs, does not exceed 2000 Euro at the time of receiving theapplication form by the competent court. This procedure does not apply to revenue, customs oradministrative matters or in regard to state responsibility for acts or omissions in exercising the publicauthority, and other matters specifically referred to in the Regulation. A cause is transboundary in naturewhen one of the parties has its habitual residence in a Member State, other than the one where the courtreceives such application. The proper procedure of application resolution for the recovery of debts withreduced value is governed by the rules of procedural law of the Member State in which the proceedings areconducted, and the execution of court of law is made by state legislation in which it takes place. The

  12. European standardization activities on residual stress analysis by neutron diffraction

    CERN Document Server

    Youtsos, A G

    2002-01-01

    A main objective of a recently completed European research project, RESTAND - residual stress standard using neutron diffraction, was to develop industrial confidence in the application of the neutron-diffraction technique for residual stress measurement and its principal deliverable was a relevant draft code of practice. In fact this draft standard was jointly developed within RESTAND and VAMAS TWA 20 - an international pre-normative research activity. As no such standard is yet available, on the basis of this draft standard document the European Standards Committee on Non-Destructive Testing (CEN TC/138) has established a new ad hoc Work Group (AHG7). The objective of this group is the development of a European pre-standard on a 'test method for measurement of residual stress by neutron diffraction'. The document contains the proposed protocol for making the measurements. It includes the scope of the method, an outline of the technique, the calibration and measurement procedures recommended, and details of ...

  13. The European Small Claims Procedure: Striking the Balance between Simplicity and Fairness in European Litigation

    NARCIS (Netherlands)

    X.E. Kramer (Xandra)

    2008-01-01

    textabstractThis article deals with the European Small Claims Procedure (ESCP). After the European Order for Payment procedure, this is the second autonomous European procedure that has been established. Attention is paid to the background of harmonization of small claims proceedings in the European

  14. European standards of the civil service integrity

    Directory of Open Access Journals (Sweden)

    L. V. Prudyus

    2016-09-01

    It was offered for further implementation of the European standards of integrity to develop a new Code of integrity for civil servants and take measures, which contain Anti-Corruption Strategy: adopt a law on the protection of persons who honestly reported regarding corruption offenses (denunciators, in particular a law concerning conducting the inspection of public servants on integrity.

  15. European standardization activities on residual stress analysis by neutron diffraction

    International Nuclear Information System (INIS)

    Youtsos, A.G.; Ohms, C.

    2002-01-01

    A main objective of a recently completed European research project, RESTAND - residual stress standard using neutron diffraction, was to develop industrial confidence in the application of the neutron-diffraction technique for residual stress measurement and its principal deliverable was a relevant draft code of practice. In fact this draft standard was jointly developed within RESTAND and VAMAS TWA 20 - an international pre-normative research activity. As no such standard is yet available, on the basis of this draft standard document the European Standards Committee on Non-Destructive Testing (CEN TC/138) has established a new ad hoc Work Group (AHG7). The objective of this group is the development of a European pre-standard on a 'test method for measurement of residual stress by neutron diffraction'. The document contains the proposed protocol for making the measurements. It includes the scope of the method, an outline of the technique, the calibration and measurement procedures recommended, and details of how the strain data should be analysed to calculate stresses and establish the reliability of the results obtained. (orig.)

  16. European standardization activities on residual stress analysis by neutron diffraction

    Science.gov (United States)

    Youtsos, A. G.; Ohms, C.

    A main objective of a recently completed European research project, RESTAND - residual stress standard using neutron diffraction, was to develop industrial confidence in the application of the neutron-diffraction technique for residual stress measurement and its principal deliverable was a relevant draft code of practice. In fact this draft standard was jointly developed within RESTAND and VAMAS TWA 20 - an international pre-normative research activity. As no such standard is yet available, on the basis of this draft standard document the European Standards Committee on Non-Destructive Testing (CEN TC/138) has established a new ad hoc Work Group (AHG7). The objective of this group is the development of a European pre-standard on a `test method for measurement of residual stress by neutron diffraction'. The document contains the proposed protocol for making the measurements. It includes the scope of the method, an outline of the technique, the calibration and measurement procedures recommended, and details of how the strain data should be analysed to calculate stresses and establish the reliability of the results obtained.

  17. EUROPEAN AND INTERNATIONAL STANDARDS ON MEDICAL DEVICES FOR DENTISTRY.

    Directory of Open Access Journals (Sweden)

    Jordan Deliversky

    2015-02-01

    Full Text Available Standards are produced for many different products and services, and may be created for company, national, regional or global application. In Europe there are three different categories of standard: International standard – a standard adopted by an international standardization organization; European standard – a standard adopted by a European standardization body; National standard – a standard adopted by a national standardization body and made available to the public. Harmonized standards play a special role in the EU. A harmonised standard is a European standard elaborated on the basis of a request from the European Commission to a recognised European Standards Organisation to develop a European standard that provides solutions for compliance with a legal provision. Most standards for dental materials have been harmonized through a so-called cumulative standard (EN 1641:2009 - Dentistry - Medical devices for dentistry - Materials. This European Standard specifies general requirements for materials used in the practice of dentistry for the restoration of the form and function of the dentition and which are medical devices. A multiplicity of laws, standards, and recommendations regulate the marketing of medical devices. The medical doctor and the dentist should be informed about the European and international standards concerning medical devices and use only those for which appropriate information is available. The manufacturer/importer is responsible for its products and is potentially liable for damages.

  18. THE MANIFESTO ON EUROPEAN CRIMINAL PROCEDURE LAW – FOUNDATION FOR CREATING A COMMON SPACE OF EUROPEAN CRIMINAL JUSTICE

    Directory of Open Access Journals (Sweden)

    Rodica PANAINTE

    2015-09-01

    Full Text Available In this article, we propose to analyze the content of the Manifesto on European Criminal Procedure Law of 2013, and how this document can represent a foundation for the legal cooperation of the European states, and also for creating a unique, common space of European criminal justice. Elaborated by the European Criminal Policy Initiative and launched on November 2013, the Manifesto on European Criminal Procedure Law contains the principles and the rules that should be followed by the European penal legislator when gives shape to the laws in the field of Criminal Procedure. This document represents a natural following of the first Manifesto, in the field of substantive criminal law of 2009. The Manifesto concerns mainly the rules and the principles of criminal procedure because, as its authors affirm, this kind of rules have increasingly been shaped lately in European regulations, and also because the regulations in this field must reflect and respect the highest standards of the rule of law, as they must continuously and without exception guarantee the fundamental rights. In this study, we propose to focus upon the legal solutions found out by the authors of the Manifesto in order to attain, during the criminal proceedings, an equilibrium between the interest of the state and even of the Union to realize an effective criminal proceedings, and the individual human rights that are affected, and also an equilibrium between the actual legal order and the traditions of the member states.

  19. AGREED-UPON PROCEDURES, PROCEDURES FOR AUDITING EUROPEAN GRANTS

    Directory of Open Access Journals (Sweden)

    Daniel Petru VARTEIU

    2016-12-01

    The audit of EU-funded projects is an audit based on agreed-upon procedures, which are established by the Managing Authority or the Intermediate Body. Agreed-upon procedures can be defined as engagements made in accordance with ISRS 4400, applicable to agreed-upon procedures, where the auditor undertakes to carry out the agreed-upon procedures and issue a report on factual findings. The report provided by the auditor does not express any assurance. It allows users to form their own opinions about the conformity of the expenses with the project budget as well as the eligibility of the expenses.

  20. European Organisation for Research and Treatment of Cancer (EORTC) Pathobiology Group standard operating procedure for the preparation of human tumour tissue extracts suited for the quantitative analysis of tissue-associated biomarkers.

    Science.gov (United States)

    Schmitt, Manfred; Mengele, Karin; Schueren, Elisabeth; Sweep, Fred C G J; Foekens, John A; Brünner, Nils; Laabs, Juliane; Malik, Abha; Harbeck, Nadia

    2007-03-01

    With the new concept of 'individualized treatment and targeted therapies', tumour tissue-associated biomarkers have been given a new role in selection of cancer patients for treatment and in cancer patient management. Tumour biomarkers can give support to cancer patient stratification and risk assessment, treatment response identification, or to identifying those patients who are expected to respond to certain anticancer drugs. As the field of tumour-associated biomarkers has expanded rapidly over the last years, it has become increasingly apparent that a strong need exists to establish guidelines on how to easily disintegrate the tumour tissue for assessment of the presence of tumour tissue-associated biomarkers. Several mechanical tissue (cell) disruption techniques exist, ranging from bead mill homogenisation and freeze-fracturing through to blade or pestle-type homogenisation, to grinding and ultrasonics. Still, only a few directives have been given on how fresh-frozen tumour tissues should be processed for the extraction and determination of tumour biomarkers. The PathoBiology Group of the European Organisation for Research and Treatment of Cancer therefore has devised a standard operating procedure for the standardised preparation of human tumour tissue extracts which is designed for the quantitative analysis of tumour tissue-associated biomarkers. The easy to follow technical steps involved require 50-300 mg of deep-frozen cancer tissue placed into small size (1.2 ml) cryogenic tubes. These are placed into the shaking flask of a Mikro-Dismembrator S machine (bead mill) to pulverise the tumour tissue in the capped tubes in the deep-frozen state by use of a stainless steel ball, all within 30 s of exposure. RNA is isolated from the pulverised tissue following standard procedures. Proteins are extracted from the still frozen pulverised tissue by addition of Tris-buffered saline to obtain the cytosol fraction of the tumour or by the Tris buffer supplemented with

  1. The skin prick test – European standards

    Directory of Open Access Journals (Sweden)

    Heinzerling Lucie

    2013-02-01

    Full Text Available Abstract Skin prick testing is an essential test procedure to confirm sensitization in IgE-mediated allergic disease in subjects with rhinoconjunctivitis, asthma, urticaria, anapylaxis, atopic eczema and food and drug allergy. This manuscript reviews the available evidence including Medline and Embase searches, abstracts of international allergy meetings and position papers from the world allergy literature. The recommended method of prick testing includes the appropriate use of specific allergen extracts, positive and negative controls, interpretation of the tests after 15 – 20 minutes of application, with a positive result defined as a wheal ≥3 mm diameter. A standard prick test panel for Europe for inhalants is proposed and includes hazel (Corylus avellana, alder (Alnus incana, birch (Betula alba, plane (Platanus vulgaris, cypress (Cupressus sempervirens, grass mix (Poa pratensis, Dactilis glomerata, Lolium perenne, Phleum pratense, Festuca pratensis, Helictotrichon pretense, Olive (Olea europaea, mugwort (Artemisia vulgaris, ragweed (Ambrosia artemisiifolia, Alternaria alternata (tenuis, Cladosporium herbarum, Aspergillus fumigatus, Parietaria, cat, dog, Dermatophagoides pteronyssinus, Dermatophagoides farinae, and cockroach (Blatella germanica. Standardization of the skin test procedures and standard panels for different geographic locations are encouraged worldwide to permit better comparisons for diagnostic, clinical and research purposes.

  2. Standardized procedure for tsunami PRA by AESJ

    International Nuclear Information System (INIS)

    Kirimoto, Yukihiro; Yamaguchi, Akira; Ebisawa, Katsumi

    2013-01-01

    After Fukushima Accident (March 11, 2011), the Atomic Energy Society of Japan (AESJ) started to develop the standard of Tsunami Probabilistic Risk Assessment (PRA) for nuclear power plants in May 2011. As Japan is one of the countries with frequent earthquakes, a great deal of efforts has been made in the field of seismic research since the early stage. To our regret, the PRA procedures guide for tsunami has not yet been developed although the importance is held in mind of the PRA community. Accordingly, AESJ established a standard to specify the standardized procedure for tsunami PRA considering the results of investigation into the concept, the requirements that should have and the concrete methods regarding tsunami PRA referring the opinions of experts in the associated fields in December 2011 (AESJ-SC-RK004:2011). (author)

  3. The European standard on planetary protection requirements.

    Science.gov (United States)

    Debus, André

    2006-01-01

    Since the beginning of solar system exploration, numerous spacecrafts have been sent towards others worlds, and one of the main goals of such missions is the search for extraterrestrial forms of life. It is known that, under certain conditions, some terrestrial entities are able to survive during cruises in space and that they may contaminate other planets (forward contamination). At another level, possible extraterrestrial life forms are unknown and their ability to contaminate the Earth's biosphere (back contamination) in the frame of sample return missions cannot be excluded. Article IX of the Outer Space Treaty (London/Washington, January 27, 1967) requires the preservation of planets and the Earth from contamination. All nations taking part in this Treaty must prevent forward and back contamination during missions exploring our solar system. Consequently, the United Nations (UN-COPUOS) has delegated COSPAR (Committee of Space Research) to take charge of planetary protection and, at present, all space-faring nations must comply with COSPAR policy and consequently with COSPAR planetary protection recommendations. Starting from these recommendations and the "CNES Planetary Protection Standard" document, a working group has been set up in the framework of the "European Cooperation for Space Standardization" (ECSS) to establish the main specifications for preventing cross-contamination between target bodies within the solar system and the Earth-moon system.

  4. Standard manufacturing procedure of Tamra Bhasma.

    Science.gov (United States)

    Jagtap, Chandrashekhar Y; Prajapati, Pradeep Kumar; Patgiri, Biswajyoti; Shukla, Vinay J

    2012-10-01

    Tamra Bhasma (incinerated copper) is one of the main weapons in the archery of Ayurvedic practitioners. Though several methods of preparation of Tamra Bhasma (TB) are found in Rasashastra classics, several difficulties occur during the preparation of a good-quality Bhasma. In this study, TB was prepared and analyzed to develop the standard manufacturing procedure. Each unit operative procedure was considered as an independent processing and an attempt was made to validate each procedure. Wire used for the purpose of electrical earthing was taken for the preparation of Bhasma. Procedures of Shodhana, Marana, and Amritikarana were followed as per the classical references. Specific temperature pattern was adopted for Puta in the electrical muffle furnace. From 500 g of Tamra, 483.4 g of black colored TB was obtained after subjecting to three Putas. Final product was detected to be cupric sulfide in X-ray diffraction. In particle size distribution analysis 10% of the material was below the size of 2 μm, while in inductive coupled plasma - atomic absorption spectrometry 58.56 wt% copper and 22.48 wt% of sulfur were found present in the final product along with the elements such as arsenic, lead, zinc, mercury, and manganese in traces.

  5. Standardization in library and information science in selected European countries

    Science.gov (United States)

    Matysek, Anna

    2015-02-01

    Standardization plays an important role in library and information science (LIS), because it gives rules to identify, classify, access, select, exploit, communicate, exchange and preserve information. Standards are developed by national, European and international organizations. The objective of the study is to present the situation of standardization in library and information science in the countries that joined the European Union in 2004. The research covered Technical Committees that take the problems of LIS, their cooperation with European Committee for Standardization (CEN) and International Organization for Standardization (ISO). The second part of the study is an analysis of LIS standards published in the last 10 years. Data on published documents were gathered from online standards directories. The documents were searched using International Classification for Standards. Retrieved standards were analyzed for their origin and status. The research illustrates the changes in the national standardization, most popular topics and the growing importance of international cooperation in standardization.

  6. Parametric Sensitivity Tests- European PEM Fuel Cell Stack Test Procedures

    DEFF Research Database (Denmark)

    Araya, Samuel Simon; Andreasen, Søren Juhl; Kær, Søren Knudsen

    2014-01-01

    performed based on test procedures proposed by a European project, Stack-Test. The sensitivity of a Nafion-based low temperature PEMFC stack’s performance to parametric changes was the main objective of the tests. Four crucial parameters for fuel cell operation were chosen; relative humidity, temperature......, pressure, and stoichiometry at varying current density. Furthermore, procedures for polarization curve recording were also tested both in ascending and descending current directions....

  7. European standards in the field of combating cyber crime

    Directory of Open Access Journals (Sweden)

    Matijašević-Obradović Jelena

    2014-01-01

    Full Text Available Cyber crime is a phenomenon which is often written and spoken about, ever since its inception, in theory, judicial and legislative practice of developed countries and international institutions. It had rapidly developed in the last decade of the 20th century, and in the 21st century its evolution has become even more evident. Countries have responded by introducing new measures in their criminal legislation, in an effort to reconcile traditional criminal law with the demands for perception, investigation and demonstration of new criminal acts. This paper presents and analyzes the most significant European standards adopted in order to create more effective national legislation in the field of combating cyber crime. Standards given in the Convention of the Council of Europe but also the European Union Directives have to a large extent been a guide for national legislations in order to regulate the new situations regarding the misuse of information and communication technologies in the most adequate manner. Among other things, this paper pays special attention to the most important Convention in the field of combating cyber crime, which is the Council of Europe Convention on cyber crime, whose objectives include: harmonization of national legislations with regard to substantive provisions in the field of cyber crime, introduction of adequate instruments in national legislations with regard to process provisions in order to create the necessary basis for investigation and prosecution of offenders in this field and establishment of quick and efficient institutions and procedures for international cooperation.

  8. 42 CFR 493.1251 - Standard: Procedure manual.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Procedure manual. 493.1251 Section 493... Systems § 493.1251 Standard: Procedure manual. (a) A written procedure manual for all tests, assays, and.... (b) The procedure manual must include the following when applicable to the test procedure: (1...

  9. European civil procedure: current status within the legal system of the European Union and its member states

    Directory of Open Access Journals (Sweden)

    Victor Terekhov

    2017-01-01

    forget, however, that a genuine federal center does not only introduce centralized procedures, but also approves mandatory standards for all of the levels of the regulatory system (in other words, pursues approximation. A right of any federal state to exercise such competence does not find any questions due to supremacy of its authority. Still in the EU legal order the principle of its supremacy has a limited application and it is not obvious that the introduction of general norms for the Civil Procedure come within it. The existence of different standards of justice (28 national ones and one supranational has a negative effect on the unity of the “area of justice”, making it illusory. In order to guarantee an equal level of judicial protection everywhere in the EU a procedural “bill of rights” is required, and it needs to be adopted at the “highest level” of the system.Conclusions. The EU Civil Procedure has a dual nature. In its own (narrow sense it is a body of federal procedural law of the EU that is applied when a cross-border situation of intracommunity character comes into being. In a broader sense, it is also a combination of norms, rules and principles of justice that are adopted by the EU as a federal center for both community-wide and national levels of the judicial system in order to guarantee the unity to the area of justice. In the ideal case, the European area of justice has to be a coherent, unified and internally consistent system. Reality is, however, far from that image, since there are multiple problems of both legal and political nature that hinder the implementa-tion of these brave ideas.

  10. Standard of Living in the European Union

    OpenAIRE

    Stávková, Jana; Žufan, Pavel; Birčiaková, Naďa

    2012-01-01

    This chapter focuses on the measurement of standard of living and on the factors influencing its level. Specific attention is paid to the indicators of standard of living, and the frequent employment of GDP is discussed and compared with possible alternatives. Household income is also a factor of central importance in determining standard of living, and the chapter assesses this factor in terms of household income distribution, the setting of poverty limits, the measurement of income disparit...

  11. Russian Higher Education and European Standards of Quality Assurance

    Science.gov (United States)

    Motova, Galina; Pykko, Ritta

    2012-01-01

    This article considers the relevance and implementation of European approaches to quality assurance in the context of the Russian educational system. It covers the issues of transformation of the higher education system during the post-Soviet period, specific features of the state accreditation system, the impact of the European Standards and…

  12. Public information and licensing procedures for nuclear installations. European experience

    International Nuclear Information System (INIS)

    Mayoux, J.C.; Chevillard, F.; Mutschler, U.; Stubbe, C.

    1981-10-01

    This paper reviews the licensing procedures for nuclear installations in various European countries and examines the form, content and methods selected for information and consultation of the public. The author stresses the importance of this stage in the procedure, both for the nuclear operator and the public authorities, given the population's concern about the environment. He concludes that, irrespective of its complexity, the nuclear field cannot remain the concern of a few initiates competent to take decisions and that, consequently, this implies creation of new information systems to meet the public's desire to participate more directly in the process. (NEA) [fr

  13. Standard procedures for adults in accredited sleep medicine centres in Europe

    DEFF Research Database (Denmark)

    Fischer, Jürgen; Dogas, Zoran; Bassetti, Claudio L

    2012-01-01

    The present paper describes standardized procedures within clinical sleep medicine. As such, it is a continuation of the previously published European guidelines for the accreditation of sleep medicine centres and European guidelines for the certification of professionals in sleep medicine, aimed...... and quality assurance of sleep medicine in Europe....... at creating standards of practice in European sleep medicine. It is also part of a broader action plan of the European Sleep Research Society, including the process of accreditation of sleep medicine centres and certification of sleep medicine experts, as well as publishing the Catalogue of Knowledge...... and Skills for sleep medicine experts (physicians, non-medical health care providers, nurses and technologists), which will be a basis for the development of relevant educational curricula. In the current paper, the standard operational procedures sleep medicine centres regarding the diagnostic...

  14. 21 CFR 120.6 - Sanitation standard operating procedures.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 2 2010-04-01 2010-04-01 false Sanitation standard operating procedures. 120.6... Provisions § 120.6 Sanitation standard operating procedures. (a) Sanitation controls. Each processor shall have and implement a sanitation standard operating procedure (SSOP) that addresses sanitation...

  15. The skin prick test - European standards

    NARCIS (Netherlands)

    Heinzerling, Lucie; Mari, Adriano; Bergmann, Karl-Christian; Bresciani, Megon; Burbach, Guido; Darsow, Ulf; Durham, Stephen; Fokkens, Wytske; Gjomarkaj, Mark; Haahtela, Tari; Bom, Ana Todo; Wöhrl, Stefan; Maibach, Howard; Lockey, Richard

    2013-01-01

    Skin prick testing is an essential test procedure to confirm sensitization in IgE-mediated allergic disease in subjects with rhinoconjunctivitis, asthma, urticaria, anapylaxis, atopic eczema and food and drug allergy. This manuscript reviews the available evidence including Medline and Embase

  16. Reporting systems in gastrointestinal endoscopy: Requirements and standards facilitating quality improvement: European Society of Gastrointestinal Endoscopy position statement

    NARCIS (Netherlands)

    Bretthauer, Michael; Aabakken, Lars; Dekker, Evelien; Kaminski, Michal F.; Rösch, Thomas; Hultcrantz, Rolf; Suchanek, Stepan; Jover, Rodrigo; Kuipers, Ernst J.; Bisschops, Raf; Spada, Cristiano; Valori, Roland; Domagk, Dirk; Rees, Colin; Rutter, Matthew D.

    2016-01-01

    To develop standards for high quality of gastrointestinal endoscopy, the European Society of Gastrointestinal Endoscopy (ESGE) has established the ESGE Quality Improvement Committee. A prerequisite for quality assurance and improvement for all gastrointestinal endoscopy procedures is

  17. NET European Network on Neutron Techniques Standardization for Structural Integrity

    International Nuclear Information System (INIS)

    Youtsos, A.

    2004-01-01

    Improved performance and safety of European energy production systems is essential for providing safe, clean and inexpensive electricity to the citizens of the enlarged EU. The state of the art in assessing internal stresses, micro-structure and defects in welded nuclear components -as well as their evolution due to complex thermo-mechanical loads and irradiation exposure -needs to be improved before relevant structural integrity assessment code requirements can safely become less conservative. This is valid for both experimental characterization techniques and predictive numerical algorithms. In the course of the last two decades neutron methods have proven to be excellent means for providing valuable information required in structural integrity assessment of advanced engineering applications. However, the European industry is hampered from broadly using neutron research due to lack of harmonised and standardized testing methods. 35 European major industrial and research/academic organizations have joined forces, under JRC coordination, to launch the NET European Network on Neutron Techniques Standardization for Structural Integrity in May 2002. The NET collaborative research initiative aims at further development and harmonisation of neutron scattering methods, in support of structural integrity assessment. This is pursued through a number of testing round robin campaigns on neutron diffraction and small angle neutron scattering - SANS and supported by data provided by other more conventional destructive and non-destructive methods, such as X-ray diffraction and deep and surface hole drilling. NET also strives to develop more reliable and harmonized simulation procedures for the prediction of residual stress and damage in steel welded power plant components. This is pursued through a number of computational round robin campaigns based on advanced FEM techniques, and on reliable data obtained by such novel and harmonized experimental methods. The final goal of

  18. From European Standard to User Service

    DEFF Research Database (Denmark)

    Jacobi, Ole Illum; Lind, Morten

    1997-01-01

    Today’s public administration and planning need access to proper spatial information. The tremendous growth in the area of maps and other geographically referenced databases increases the needs of the user as well as the supplier of information for an overview of the jungle of spatial data....... The answer to this need is a metadata service that gives relevant and up-to-date, at-your-fingertips information on available geographical datasets.As a result of the work in the standardization organizations, we are now, luckily, able to take the first steps towards an implementation of metadata services...... in the design of the next generation of metadata services.On the basis of recent Danish experiences with implementation of the CEN/TC 287 standard into a WWW Geographical Information metadata service, we will present and discuss some general issues: The conceptual strategy, the implementation of dataset...

  19. European Union competition law, intellectual property law and standardization

    NARCIS (Netherlands)

    Geradin, Damien; Contreras, Jorge L.

    2016-01-01

    This paper provides an overview of the efforts of the European Commission to identify and, when necessary, challenge anticompetitive behaviour with respect to standardization and the licensing of standardized technologies, as well as the case-law of the CJEU on the same subject. The paper starts by

  20. European standardization activities on safety of liquid helium cryostats

    CERN Multimedia

    CERN. Geneva

    2016-01-01

    This talk gives a general overview on the challenges of designing safety units for liquid helium cryostats with regard to existing industry standards. It reviews the work of a national working group that published the technical guideline DIN SPEC 4683 in April 2015, which is dedicated to the particular conditions in liquid helium cryostats. Based on both this guideline and equivalent documents from e.g. CEA, CERN, a working group is being formed at the European Committee for Standardization, associated to CEN/TC 268, which will work on a European standard on safety of liquid helium cryostats. The actual status and the schedule of this project are presented.

  1. [Biocontamination, European standardization and pharmaceutical industry].

    Science.gov (United States)

    Isoard, P; Vidal, D; Thibault, F; Ducel, G

    1993-01-01

    The coming to light of new concepts in environmental microbiology, particularly the notions of bacterial adhesion and of biofilm or of cells in starvation, conducted to an evolution of the standardization of the controlled contamination area. It is necessary to match to the biocontamination of hazard area the principles governing the quality insurance used in alimentary industry named HACCP (hazard analysis of control critical point). This method will have to be applied wilfully to all the fields where a patient or a product risk a biocontamination.

  2. NedWind 25 Blade Testing at NREL for the European Standards Measurement and Testing Program

    Energy Technology Data Exchange (ETDEWEB)

    Larwood, S.; Musial, W.; Freebury, G.; Beattie, A.G.

    2001-04-19

    In the mid-90s the European community initiated the Standards, Measurements, and Testing (SMT) program to harmonize testing and measurement procedures in several industries. Within the program, a project was carried out called the European Wind Turbine Testing Procedure Development. The second part of that project, called Blade Test Methods and Techniques, included the United States and was devised to help blade-testing laboratories harmonize their testing methods. This report provides the results of those tests conducted by the National Renewable Energy Laboratory.

  3. 40 CFR 761.79 - Decontamination standards and procedures.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 30 2010-07-01 2010-07-01 false Decontamination standards and..., AND USE PROHIBITIONS Storage and Disposal § 761.79 Decontamination standards and procedures. (a) Applicability. This section establishes decontamination standards and procedures for removing PCBs, which are...

  4. Standardization of Ukrainian touristic services within framework of European integration

    Directory of Open Access Journals (Sweden)

    O.V. Milinchuk

    2015-06-01

    Full Text Available The harmonization of national standards in tourism to international requirements is a prerequisite to perform in accordance with the signed Ukraine and the European Union Association Agreement. The current situation of the national standardization in tourism and directions of its development in the context of European integration are formed in the article. The content and objectives of standardization in the field of tourism are determined. The legislation of the national tourism standardization is reviewed: there are 11 standards in the field of tourism, including 6 interstate standards (GOST which adapted as national. The current system of standards has a numerous outdated requirements, Ukrainian enterprises doesn’t use international standards on the organization of trips of adventure tourism, safety management, customer service on cruise ships and ferries, requirements for tourist services etc. In order to satisfy the requirements of quality of tourism services to the European level is recommended to adapt existing ISO standards to the national tourism legislation and to approve them in 2017.

  5. European and International Standards on health and safety in welding

    Science.gov (United States)

    Howe, A.

    2009-02-01

    A number of European and International Standards on health and safety in welding have been published in recent years and work on several more is nearing completion. These standards have been prepared jointly by the International Standards Organization (ISO) and the European Committee for Standardization (CEN). The standards development work has mostly been led by CEN/TC 121/SC 9, with excellent technical input from experts within Europe; but work on the revision of published standards, which has recently gathered pace, is now being carried out by ISO/TC 44/SC 9, with greater international involvement. This paper gives an overview of the various standards that have been published, are being revised or are under development in this field of health and safety in welding, seeking to (i) increase international awareness of published standards, (ii) encourage wider participation in health and safety in welding standards work and (iii) obtain feedback and solicit comments on standards that are currently under development or revision. Such an initiative is particularly timely because work is currently in progress on the revision of one of the more important standards in this field, namely EN ISO 10882:2001 Health and safety in welding and allied processes— Sampling of airborne particles and gases in the operator's breathing zone — Part 1: Sampling of airborne particles.

  6. Standard-E hydrogen monitoring system shop acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, T.C.

    1997-10-02

    The purpose of this report is to document that the Standard-E Hydrogen Monitoring Systems (SHMS-E), fabricated by Mid-Columbia Engineering (MCE) for installation on the Waste Tank Farms in the Hanford 200 Areas, are constructed as intended by the design. The ATP performance will verify proper system fabrication.

  7. Standard manufacturing procedure of Teekshna lauha bhasma

    Directory of Open Access Journals (Sweden)

    Thakur Rakesh Singh

    2016-04-01

    Conclusion: Pharmaceutical procedures given in Ayurvedic texts are necessary to prepare pakwa jambu phala varna T. lauha bhasma that complies with all the classical bhasma pariksha and modern analytical parameters in 20 puta at a temperature of 650 °C maintained for 1 h in EMF.

  8. 77 FR 12454 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2012-03-01

    ... DEPARTMENT OF TRANSPORTATION Federal Aviation Administration 14 CFR Part 97 [Docket No. 30829; Amdt. No. 3467] Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures; Miscellaneous Amendments AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule...

  9. 42 CFR 493.1256 - Standard: Control procedures.

    Science.gov (United States)

    2010-10-01

    ... results are used, statistical parameters (for example, mean and standard deviation) for each batch and lot... 42 Public Health 5 2010-10-01 2010-10-01 false Standard: Control procedures. 493.1256 Section 493... (CONTINUED) STANDARDS AND CERTIFICATION LABORATORY REQUIREMENTS Quality System for Nonwaived Testing Analytic...

  10. Road safety audit tools, procedures, and experiences : a literature review and recommendations : research in the framework of the European research project Safety Standards for Road Design and Redesign SAFESTAR, Workpackage 8.

    NARCIS (Netherlands)

    Kooi, R.M. van der

    1999-01-01

    This report describes tools and procedures established in different countries which apply Road Safety Audits (RSA). These RSAs are utilized to identify potential safety problems and they concentrate on safety measures to overcome these problems. This technique is used to detect possible safety

  11. Procedural abortion rights: Ireland and the European Court of Human Rights.

    Science.gov (United States)

    Erdman, Joanna N

    2014-11-01

    The Irish Protection of Life During Pregnancy Act seeks to clarify the legal ground for abortion in cases of risk to life, and to create procedures to regulate women's access to services under it. This article explores the new law as the outcome of an international human rights litigation strategy premised on state duties to implement abortion laws through clear standards and procedural safeguards. It focuses specifically on the Irish law reform and the jurisprudence of the European Court of Human Rights, including A. B. and C. v. Ireland (2010). The article examines how procedural rights at the international level can engender domestic law reform that limits or expands women's access to lawful abortion services, serving conservative or progressive ends. Copyright © 2014 Reproductive Health Matters. Published by Elsevier Ltd. All rights reserved.

  12. JSC Design and Procedural Standards, JSC-STD-8080

    Science.gov (United States)

    Punch, Danny T.

    2011-01-01

    This document provides design and procedural requirements appropriate for inclusion in specifications for any human spaceflight program, project, spacecraft, system, or end item. The term "spacecraft" as used in the standards includes launch vehicles, orbital vehicles, non-terrestrial surface vehicles, and modules. The standards are developed and maintained as directed by Johnson Space Center (JSC) Policy Directive JPD 8080.2, JSC Design and Procedural Standards for Human Space Flight Equipment. The Design and Procedural Standards contained in this manual represent human spacecraft design and operational knowledge applicable to a wide range of spaceflight activities. These standards are imposed on JSC human spaceflight equipment through JPD 8080.2. Designers shall comply with all design standards applicable to their design effort.

  13. Integrated Pest Management as European standard – is it possible?

    Directory of Open Access Journals (Sweden)

    Lisa Nilsen

    2011-08-01

    Full Text Available As part of the work within the European Committee for Standardization (CEN, standards for conservation of cultural property are being developed in CEN/TC (Technical Committee 346, Conservation of Cultural Property. In Working Group 4 Environment, a draft is being prepared to create a proposal for standardised Integrated Pest Management. The author of this paper welcomes delegates to the Meeting on Cultural Heritage Pests in Piacenza to contribute to the discussion regarding standardised methods for pest control in the cultural heritage sector.

  14. The European standard series in 9 European countries, 2002/2003 - First results of the European Surveillance System on Contact Allergies

    NARCIS (Netherlands)

    Uter, W; Hegewald, J; Aberer, W; Ayala, F; Bircher, AJ; Brasch, J; Coenraads, PJ; Schuttelaar, Marielouise; Elsner, P; Fartasch, M; Mahler, V.; Fortina, AB; Frosch, PJ; Fuchs, T; Johansen, JD; Menne, T; Jolanki, R; Krecisz, B; Kiec-Swierczynska, M; Larese, F; Orton, D; Peserico, A; Rantanen, T; Schnuch, A

    Since January 2001, the European Surveillance System on Contact Allergies (ESSCA), supported by European Union funding (contract QLK4-CT-2001-00343), has started to collect patch-test data. This comprises a standardized clinical history and the patch-test results using the European standard series,

  15. Towards an Administrative Procedure of the European Union: Issues and Prospects

    Directory of Open Access Journals (Sweden)

    Mihaela V. Cărăuşan

    2016-12-01

    Full Text Available This article aims at identifying European administrative law principles by mapping the proposal of the European Parliament and assessing the existing principles in the European Union’s rules and jurisprudence. The first section analyses the difficulties to pass from the well-known sectoral procedures to a common procedural framework. It shows, on the one hand, how fragmented is the administrative EU law, and on the other hand, that European Commission tends to support it by derailing the Parliament’s proposal. The second section, is mapping the administrative law principles through an inventory of the Treaties, the Charter, the soft law and the jurisprudence. The last section proposes an assessment of the draft Regulation on the administrative procedure of European Union. The main outcome is that, without the Commission’s involvement the process of making a common administrative procedure for European Union cannot take place.

  16. The European standard series. European Environmental and Contact Dermatitis Research Group (EECDRG)

    DEFF Research Database (Denmark)

    Bruynzeel, D P; Andersen, Klaus Ejner; Camarasa, J G

    1995-01-01

    Changes to the European standard series which have taken place since the last officially recommended alterations in 1988, are explained. New to the series is the sesquiterpene lactone mix. The PPD black rubber mix and the quinoline mix have been replaced by single components; one of the p-hydroxy......-hydroxybenzoates has been left out of the paraben mix. Ethylenediamine dihydrochloride has been dropped from the series....

  17. OGC Web Services standards by example : the European Seismic Portal

    Science.gov (United States)

    Frobert, L.; Kamb, L.; Trani, L.; Spinuso, A.; Bossu, R.; Van Eck, T.

    2011-12-01

    NERIES (2006-2010) was an Integrated Infrastructure Initiative (I3) project in the Sixth Framework Program (FP6) of the European Commission (EC), aiming at networking the European seismic networks, improving access to data, allowing access to specific seismic infrastructures and pursuing targeted research developing the next generation of tools for improved service and data analysis. During this project, a web portal was developed using web services to access data and a Visual Web Applications to display them. However these web services were not conform to any standard, making them difficult to consume by any new user interface. Therefore, for the NERA project, the follow-up of NERIES, we have proposed the use of web services standards to access our data. We have decided to use standards defined by the Open Geospatial Consortium (OGC). The OGC defines standards for the Web service interfaces to access geo-tagged data. The events and seismic stations are also geo-tagged making these web services suitable for our purpose. Using standard web services gives us the opportunity to distribute our data across all conformant consumers to these standards through various programming languages and applications We have implemented a preliminary version of web services conforming to the Web Map Service (WMS) and Web Feature Service (WFS) standard to access our catalog of seismic events (nearly 200 000 events). To visualize them we have made four examples demo on our web site using different technologies (Adobe Flash, JavaScript, Java with Nasa World Wind and UDig a desktop GIS application). In the future we hope to implement other OGC Web services standard like : - Sensor Observation Service (SOS) to provide seismic waveform records; - Web Notification Service (WNS); - Catalog Service for the Web (CSW) to provide a search engine of all our web services; - Web Processing Service (WPS) to process data between different services. The power of the use of OGC standards is the easy

  18. Pediatric otorhinolaryngology anno 2008: towards European standards for training?

    LENUS (Irish Health Repository)

    Verwoerd, Carel

    2009-06-01

    The Union Européen des Médecins Spécialistes (UEMS) has been promoting harmonization of specialist training programs in Europe. Anticipating a future contribution to a European standard for training specialists for tertiary care of children with otorhinolaryngology (ORL)-related problems this Round Table was organized by ESPO. The presentations refer to six European countries. The number of ORL specialists (including pediatric ORL specialists) appeared to vary from +\\/-8 to +\\/-1 per 100,000 inhabitants, suggesting significant differences as far as their contribution to health care is concerned. Numbers for pediatricians vary from 12 to 3 and for family doctors from 50 to 100 per 100,000. In two countries pediatric ORL has the status of an official sub-specialty for tertiary care, requiring at least 2 years of additional training for qualified ORL specialists. In three other countries specific centers for pediatric ORL are present, although the sub-specialty has no official status. In the last a center for pediatric otorhinolaryngology has not yet been established and facilities for training in pediatric ORL are not available. For each country various aspects of current practice of tertiary ORL care for children are presented. It is concluded that a European standard for pediatric ORL could be most useful, if it would not only refer to current diagnostic and therapeutic skills but also to relevant scientific knowledge and skills. However, it should be recognized that the relevance of today\\'s standards is restricted, as medicine and medical technology are rapidly developing.

  19. Biomass and abundance biases in European standard gillnet sampling

    Czech Academy of Sciences Publication Activity Database

    Šmejkal, Marek; Ricard, Daniel; Prchalová, Marie; Říha, Milan; Muška, Milan; Blabolil, Petr; Čech, Martin; Vašek, Mojmír; Jůza, Tomáš; Herreras, A.M.; Encina, L.; Peterka, Jiří; Kubečka, Jan

    2015-01-01

    Roč. 10, č. 3 (2015), e0122437 E-ISSN 1932-6203 R&D Projects: GA MŠk(CZ) EE2.3.20.0204; GA ČR(CZ) GPP505/12/P647; GA MŠk(CZ) EE2.3.30.0032 Institutional support: RVO:60077344 Keywords : fish sampling * gillnets * large meshes * mesh size selectivity * Improvement of European standard EN 14757 * bream (Abramis brama) Subject RIV: GL - Fishing Impact factor: 3.057, year: 2015

  20. Physical fitness reference standards in European children: the IDEFICS study.

    Science.gov (United States)

    De Miguel-Etayo, P; Gracia-Marco, L; Ortega, F B; Intemann, T; Foraita, R; Lissner, L; Oja, L; Barba, G; Michels, N; Tornaritis, M; Molnár, D; Pitsiladis, Y; Ahrens, W; Moreno, L A

    2014-09-01

    A low fitness status during childhood and adolescence is associated with important health-related outcomes, such as increased future risk for obesity and cardiovascular diseases, impaired skeletal health, reduced quality of life and poor mental health. Fitness reference values for adolescents from different countries have been published, but there is a scarcity of reference values for pre-pubertal children in Europe, using harmonised measures of fitness in the literature. The IDEFICS study offers a good opportunity to establish normative values of a large set of fitness components from eight European countries using common and well-standardised methods in a large sample of children. Therefore, the aim of this study is to report sex- and age-specific fitness reference standards in European children. Children (10,302) aged 6-10.9 years (50.7% girls) were examined. The test battery included: the flamingo balance test, back-saver sit-and-reach test (flexibility), handgrip strength test, standing long jump test (lower-limb explosive strength) and 40-m sprint test (speed). Moreover, cardiorespiratory fitness was assessed by a 20-m shuttle run test. Percentile curves for the 1st, 3rd, 10th, 25th, 50th, 75th, 90th, 97th and 99th percentiles were calculated using the General Additive Model for Location Scale and Shape (GAMLSS). Our results show that boys performed better than girls in speed, lower- and upper-limb strength and cardiorespiratory fitness, and girls performed better in balance and flexibility. Older children performed better than younger children, except for cardiorespiratory fitness in boys and flexibility in girls. Our results provide for the first time sex- and age-specific physical fitness reference standards in European children aged 6-10.9 years.

  1. Standard Review Plan Maintenance Program implementing procedures document

    International Nuclear Information System (INIS)

    1996-11-01

    The implementing Procedures Document (IPD) was developed by the Inspection Program Projects Branch, Office of Nuclear Reactor Regulation, with assistance from Pacific Northwest National Laboratory, for the Standard Review Plan Maintenance Program (SRP-MP). The SRP-MP was established to maintain the Standard Review Plan (SRP) on an on-going basis. The IPD provides guidance, including an overall approach and procedures, for SRP-MP tasks. The objective of the IPD is to ensure that modifications to SRP need to reflect current NRC requirements and guidance are identified and that a consistent methodology is used to develop and revise SRP sections

  2. Standard Review Plan Update and Development Program. Implementing Procedures Document

    Energy Technology Data Exchange (ETDEWEB)

    1992-05-01

    This implementing procedures document (IPD) was prepared for use in implementing tasks under the standard review plan update and development program (SRP-UDP). The IPD provides comprehensive guidance and detailed procedures for SRP-UDP tasks. The IPD is mandatory for contractors performing work for the SRP-UDP. It is guidance for the staff. At the completion of the SRP-UDP, the IPD will be revised (to remove the UDP aspects) and will replace NRR Office Letter No. 800 as long-term maintenance procedures.

  3. Standardized methods for photography in procedural dermatology using simple equipment.

    Science.gov (United States)

    Hexsel, Doris; Hexsel, Camile L; Dal'Forno, Taciana; Schilling de Souza, Juliana; Silva, Aline F; Siega, Carolina

    2017-04-01

    Photography is an important tool in dermatology. Reproducing the settings of before photos after interventions allows more accurate evaluation of treatment outcomes. In this article, we describe standardized methods and tips to obtain photographs, both for clinical practice and research procedural dermatology, using common equipment. Standards for the studio, cameras, photographer, patients, and framing are presented in this article. © 2017 The International Society of Dermatology.

  4. [Marketing of medicinal products in the European Community. The Mutual Recognition and Decentralised Procedures].

    Science.gov (United States)

    Bachmann, Peter

    2008-07-01

    The Mutual Recognition Procedure (MRP) and the Decentralised Procedure (DCP), which were first established in late 2005, can be regarded as the backbone for marketing authorisation of medicinal products in the European Community (EC) and the European Economic Area (EEA). Both procedures are compared and advantages and disadvantages are discussed. However, the focus is more related to current developments than the detailed comparison of both procedures. The role of the Coordination Group for Mutual Recognition and Decentralised Procedures-Human (CMD(h)) and the decision making process in relation to the MRP and DCP is also discussed.

  5. Requirements and standards facilitating quality improvement for reporting systems in gastrointestinal endoscopy: European Society of Gastrointestinal Endoscopy (ESGE) Position Statement

    NARCIS (Netherlands)

    Bretthauer, Michael; Aabakken, Lars; Dekker, Evelien; Kaminski, Michal F.; Rösch, Thomas; Hultcrantz, Rolf; Suchanek, Stepan; Jover, Rodrigo; Kuipers, Ernst J.; Bisschops, Raf; Spada, Cristiano; Valori, Roland; Domagk, Dirk; Rees, Colin; Rutter, Matthew D.

    2016-01-01

    To develop standards for high quality in gastrointestinal (GI) endoscopy, the European Society of Gastrointestinal Endoscopy (ESGE) has established the ESGE Quality Improvement Committee. A prerequisite for quality assurance and improvement for all GI endoscopy procedures is state-of-the-art

  6. 21 CFR 58.81 - Standard operating procedures.

    Science.gov (United States)

    2010-04-01

    ... following: (1) Animal room preparation. (2) Animal care. (3) Receipt, identification, storage, handling... 21 Food and Drugs 1 2010-04-01 2010-04-01 false Standard operating procedures. 58.81 Section 58.81 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL GOOD...

  7. Aligning English grammar testing with European language standards

    Directory of Open Access Journals (Sweden)

    Bodrič Radmila

    2015-01-01

    Full Text Available In recent years, foreign language testing has gained in significance with the advent of The Common European Framework of Reference for Languages (2001 (CEFR, a European language document which set comparable standards for learning, teaching and assessing foreign languages. The CEFR was used to set the research aim of this paper - testing grammar at level B2. The main aim of the research was to determine grammatical competence at level B2 and additional aims included: (a determining which particular areas of grammar need to be learned by students at level B2, (b formulating grammatical descriptors for each individual area of grammar, (c determining the test’s threshold level which would fulfil the criteria for grammatical competence at level B2, and (d determining the extent to which students have mastered the given areas. The pre-testing was followed by the main testing on the sample of 164 students in two secondary schools. The results indicated that the quantity and quality of grammatical competence was lower than expected: 47% of the population failed to fulfil the basic level of grammatical competence. The causes may be attributed to the factors of a subjective and objective nature. Level B2 is demanding qualitatively as well as quantitatively, regarding both the formal and the functional complexity and scope of language use, which requires intensive language production, high levels of motivation and sound working habits in order to master the given grammatical structures.

  8. Standardization of fertilization protocols for the European eel, Anguilla anguilla

    DEFF Research Database (Denmark)

    Butts, Ian; Sørensen, Sune Riis; Politis, Sebastian Nikitas

    2014-01-01

    Standardization of artificial fertilization protocols for the European eel, Anguilla anguilla, is a prerequisite for optimizing the use of available gametes in hatchery facilities and for conserving sperm from high quality males, which is either cryopreserved or in living gene banks. The objectives...... of this research were to provide a rapid, accurate and precise method to quantify sperm density by examining the relationship between sperm density and absorbance by use of a spectrophotometer, determine the optimal number of sperm required to fertilize eggs in a controlled setting, and explore how long eggs...... are receptive to fertilization post-stripping. Mean sperm density and absorbance at 350nm were 1.54e+10±4.95e+9sperm/mL and 1.91±0.22nm, respectively. Regression analysis demonstrated a highly significant positive relationship between sperm density and absorbance using a spectrophotometer at 350nm (R2=0.94, p

  9. VERIFICATION PROCEDURE EUROPEAN FUNDED PROJECTS THROUGH FINANCIAL AUDITS

    Directory of Open Access Journals (Sweden)

    Riana Iren RADU

    2014-06-01

    Full Text Available The work developed by the authors assumes a definite need for reflection on funding mechanisms and macroeconomic management at all levels of budget deficit, amid the economic crisis unprecedented in the recent history of Romania and the whole of Europe. In this direction, this paper attempts to highlight issues that arise in terms of absorption of European funds for economic development based on this absorption emphasizing the role of grants in the economy and the need to audit projects.

  10. Hip arthroplasty in obese patients: rising prevalence – standard procedures?

    Directory of Open Access Journals (Sweden)

    Michael Skutek

    2016-06-01

    Full Text Available We examined our experience and, in particular, complications associated with total hip arthroplasty in obese and morbidly obese patients. We prospectively gathered 50 patients in a matched control series including 25 obese and morbidly obese patients. All patients were operated using the direct lateral approach and standard postoperative protocols. Operating room time, complications, dislocations, blood loss, cup position and clinical parameters using the Harris Hip Score and the Western Ontario and McMaster Universities Arthritis Index results were compared. Although there were some significant differences in clinical outcomes, standard procedures yielded good overall results and an acceptable rate of complications. Details approaching this patient entity are being discussed.

  11. Quality assurance: Importance of systems and standard operating procedures

    OpenAIRE

    Kishu Manghani

    2011-01-01

    It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality...

  12. Standard operating procedures for serum and plasma collection: early detection research network consensus statement standard operating procedure integration working group.

    Science.gov (United States)

    Tuck, Melissa K; Chan, Daniel W; Chia, David; Godwin, Andrew K; Grizzle, William E; Krueger, Karl E; Rom, William; Sanda, Martin; Sorbara, Lynn; Stass, Sanford; Wang, Wendy; Brenner, Dean E

    2009-01-01

    Specimen collection is an integral component of clinical research. Specimens from subjects with various stages of cancers or other conditions, as well as those without disease, are critical tools in the hunt for biomarkers, predictors, or tests that will detect serious diseases earlier or more readily than currently possible. Analytic methodologies evolve quickly. Access to high-quality specimens, collected and handled in standardized ways that minimize potential bias or confounding factors, is key to the "bench to bedside" aim of translational research. It is essential that standard operating procedures, "the how" of creating the repositories, be defined prospectively when designing clinical trials. Small differences in the processing or handling of a specimen can have dramatic effects in analytical reliability and reproducibility, especially when multiplex methods are used. A representative working group, Standard Operating Procedures Internal Working Group (SOPIWG), comprised of members from across Early Detection Research Network (EDRN) was formed to develop standard operating procedures (SOPs) for various types of specimens collected and managed for our biomarker discovery and validation work. This report presents our consensus on SOPs for the collection, processing, handling, and storage of serum and plasma for biomarker discovery and validation.

  13. 75 FR 72942 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-11-29

    ...: Harry J. Hodges, Flight Procedure Standards Branch (AFS-420), Flight Technologies and Programs Divisions..., SD, Rapid City Rgnl, ILS OR LOC RWY 32, Amdt 19 Newport News, VA, Newport News/Williamsburg Intl, ILS OR LOC RWY 7, Amdt 33 Newport News, VA, Newport News/Williamsburg Intl, ILS OR LOC RWY 25, Amdt 1...

  14. DNA data in criminal procedure in the European fundamental rights context.

    Science.gov (United States)

    Soleto, Helena

    2014-01-01

    Despite being one of the most useful and reliable identification tools, DNA profiling in criminal procedure balances on the border between the limitation and violation of Fundamental Rights that can occur beginning with the collection of the sample, its analysis, and its use; and ending with its processing. Throughout this complex process, violation of human or fundamental rights -such as the right to physical and moral integrity, the right not to be subject to degrading treatment, the right not to incriminate oneself, the right to family privacy together with that of not incriminating descendants or relatives in general, the right to personal development and the right to informative self-determination- is possible. This article presents an analysis of all the above-mentioned DNA treating phases in criminal process in the light of possible violations of some Fundamental Rights, while at the same time discarding some of them on the basis of European human rights protection standards. As the case-law of the European Court of Human Rights shows, the legislation on DNA collection and DNA related data processing or its implementation does not always respect all human rights and should be carefully considered before its adoption and during its application.

  15. Standardization of SMP procedure and its impact on outcome

    Directory of Open Access Journals (Sweden)

    Rachita S Dhurat

    2017-01-01

    Full Text Available Background: Cosmetic deformities can result from various types of alopecia or even post hair transplantation procedures. Patients with such deformities seek aesthetically appealing longer-lasting options. Scalp concealers are commonly used by men and women to camouflage these deformities. Scalp micropigmentation (SMP is one of the concealers recently gaining popularity. Objectives: SMP is a novel technique wherein microdot tattoos are placed in a stippling pattern to mimic hair follicles that are cut close to the scalp and various variables affecting its outcome were evaluated. Methods: Forty-five subjects were recruited for the study. The various factors affecting outcome of SMP—angle of needle against the scalp, depth of needle into the scalp, time of the needle contact in scalp, speed of the rotor, resistance of scalp, color of pigment, viscosity of dye, needle number, needle thickness, and pattern of dot placement—were systematically studied in 15 patients through clinical photographs and trichoscopy. Ideal depth of pigment deposition was assessed through histopathological examination. After using these optimum variables, standardized SMP was performed in 30 patients with hair loss (3 patients with cicatricial and 27 patients with diffuse non-cicatricial alopecia. SMP was also used to create an aesthetically denser hairline. The outcome of the procedure was evaluated using standardized global photographs. Results: The ideal parameters were established to achieve standard reproducible results. There were great patient satisfaction and acceptance of the procedure. All the patients showed moderate to great improvement after the procedure with satisfactory scalp coverage. Adverse events were transient which were seen in the form of edema and redness. Conclusion: SMP offers a non-medical, tattoo-based cosmetically appealing and effective “cover-up” that hides the unsightly conditions. The cosmetic tattoo placement creates an illusion of

  16. Bank Insolvency Procedures and Market Discipline in European Banking

    DEFF Research Database (Denmark)

    Angkinand, Apanard; Wihlborg, Clas

    2005-01-01

    Predetermined, operational procedures for dealing with banks in distress are conspicuously absent across the world with very few exceptions. Instead governments and regulatory authorities intervene when banks approach failure. Bail-outs of important creditors, sometimes including shareholders......, and blanket guarantees for creditors become the norm. We argue that efficient incentives of banks' creditors, as well as of shareholders and managers, require predetermined rules for dealing with banks in distress, and a group of creditors that are credibly non-insured. Cross-border banking increases the need...... for pre-determined bank insolvency procedures that could enable banks to expand cross-border in branches. In the empirical part we show that credibility of non-insurance is maximized with a partial deposit insurance scheme, and that the coverage can be decreased if effective rule-based distress resolution...

  17. Standard working procedures in production of traditionally fermented Sremska sausage

    Directory of Open Access Journals (Sweden)

    Vesković-Moračanin Slavica

    2011-01-01

    Full Text Available Investigations conducted within project "Techonological and protective characteristics of autochthonous strains of lactic acid bacteria isolated from traditional fermented sausages and possibilities for their implementation in the meat industry" (Project Number: 20127, financed on behalf of the Ministry for Science and Technology of the Republic of Serbia, have provided an answer on the characteristics of the quality of the used raw materials for the production of Sremska sausage - one of the most well-known Serbian traditionally fermented sausages (choice of meat, fatty tissue, additives and spices, and data have been registered in connection with the procedures of their processing, microclimatic conditions have been established (temperature, relative humidity, and air circulation during the entire process of production and fermentation, as well as the presence and types of microorganisms, primarily lactic acid bacteria (BMK, the carrier of lactic fermentation. The most important characteristics of the filling have been established, the smoking regimen, the regimens of fermentation, maturing, drying, as well as the parameters for quality and safety of the finished product. At the same time, the standard working procedure has been determined for the preparation of the meat, fatty tissue, the forming and inserting of the filling into the wrappers, as well as the characteristics of the finished products. The given standard working procedure should serve as a guideline for the meat industry in the production process of this traditional fermented sausage.

  18. Environmental Sciences Division Toxicology Laboratory standard operating procedures

    Energy Technology Data Exchange (ETDEWEB)

    Kszos, L.A.; Stewart, A.J.; Wicker, L.F.; Logsdon, G.M.

    1989-09-01

    This document was developed to provide the personnel working in the Environmental Sciences Division's Toxicology Laboratory with documented methods for conducting toxicity tests. The document consists of two parts. The first part includes the standard operating procedures (SOPs) that are used by the laboratory in conducting toxicity tests. The second part includes reference procedures from the US Environmental Protection Agency document entitled Short-Term Methods for Estimating the Chronic Toxicity of Effluents and Receiving Waters to Freshwater Organisms, upon which the Toxicology Laboratory's SOPs are based. Five of the SOPs include procedures for preparing Ceriodaphnia survival and reproduction test. These SOPs include procedures for preparing Ceriodaphnia food (SOP-3), maintaining Ceriodaphnia cultures (SOP-4), conducting the toxicity test (SOP-13), analyzing the test data (SOP-13), and conducting a Ceriodaphnia reference test (SOP-15). Five additional SOPs relate specifically to the fathead minnow (Pimephales promelas) larval survival and growth test: methods for preparing fathead minnow larvae food (SOP-5), maintaining fathead minnow cultures (SOP-6), conducting the toxicity test (SOP-9), analyzing the test data (SOP-12), and conducting a fathead minnow reference test (DOP-14). The six remaining SOPs describe methods that are used with either or both tests: preparation of control/dilution water (SOP-1), washing of glassware (SOP-2), collection and handling of samples (SOP-7), preparation of samples (SOP-8), performance of chemical analyses (SOP-11), and data logging and care of technical notebooks (SOP-16).

  19. The Right to Interpretation and Translation in Criminal Proceedings. The Exigencies Imposed by the European Union. National Standards

    Directory of Open Access Journals (Sweden)

    Mircea DAMASCHIN

    2012-08-01

    Full Text Available In the present study we have analysed the right to interpretation and translation in criminal proceedings in accordance with the European Union and national regulations in the matter. From this point of view, we took into consideration EU Directives and the Romanian legal framework in criminal procedural matters (norms provided by the Criminal Procedure Code in force and provisions of the new Criminal Procedure Code. We are going to approach the present topic from a legislative perspective and also in relation to special literature in the matter and jurisprudence solutions. In the special literature from Romania, as far as we know, this topic was not studied before, the present study being one of the first attempts to analyse the national legislation comparing it to the European standards in this matter. We are going to separately analyse the right to interpretation and the right to translation in criminal proceedings. As it will be observed, there are relevant differences among the existing procedural rights and the minimum standards from this field, the presentation of this differences representing an aspect of novelty for the researchers, especially from the perspective of the fact that the European standards must be implemented within the national legislation by October 2013.

  20. The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines

    NARCIS (Netherlands)

    Chapman, Martin D.; Ferreira, Fatima; Villalba, Mayte; Cromwell, Oliver; Bryan, Donna; Becker, Wolf-Meinhard; Fernández-Rivas, Montserrat; Durham, Stephen; Vieths, Stefan; van Ree, Ronald; Aalbers, M.; Notten, S.; Ooievaar-de Heer, P.; Ferreira, F.; Gademaier, G.; Wallner, M.; Villalba, M.; Rodriguez, R.; Becker, W.-M.; Eberhardt, F.; Lepp, U.; Raulf-Heimsoth, M.; Valenta, R.; Focke, M.; Bryan, D.; Dolman, C.; Das, R. G.; Vieths, S.; Fötisch, K.; Di Felice, G.; Pini, C.; Cromwell, O.; Fiebig, H.; Weber, B.; van Schijndel, H.; Dorpema, J. W.; Marco, F. M.; Monsalve, R.; Barber, D.; Caldas, E. Fernandez; Moingeon, P.; Didierlaurent, A.; André, C.; Kroon, A.; Neubauer, A.; Chapman, M.; Vailes, L.; Tsay, A.; Durham, S.; Custovic, A.; Simpson, B.; Knulst, A.; Rivas, M. Fernández; Mancebo, E. Gonzalez; Bahima, A. Cistero; Moncin, M. M. San Miguel; Mari, A.; Kinaciyan, T.; Quiralte, J.; Pauli, G.; de Blay, F.; Purohit, A.; Rak, S.

    2008-01-01

    Allergen measurements are used extensively in the formulation of allergy diagnostics and vaccines, yet no purified international allergen standards are available for calibration purposes. The aims of the European Union CREATE project were to develop international standards with verifiable allergen

  1. "Heidelberg standard examination" and "Heidelberg standard procedures" - Development of faculty-wide standards for physical examination techniques and clinical procedures in undergraduate medical education.

    Science.gov (United States)

    Nikendei, C; Ganschow, P; Groener, J B; Huwendiek, S; Köchel, A; Köhl-Hackert, N; Pjontek, R; Rodrian, J; Scheibe, F; Stadler, A-K; Steiner, T; Stiepak, J; Tabatabai, J; Utz, A; Kadmon, M

    2016-01-01

    The competent physical examination of patients and the safe and professional implementation of clinical procedures constitute essential components of medical practice in nearly all areas of medicine. The central objective of the projects "Heidelberg standard examination" and "Heidelberg standard procedures", which were initiated by students, was to establish uniform interdisciplinary standards for physical examination and clinical procedures, and to distribute them in coordination with all clinical disciplines at the Heidelberg University Hospital. The presented project report illuminates the background of the initiative and its methodological implementation. Moreover, it describes the multimedia documentation in the form of pocketbooks and a multimedia internet-based platform, as well as the integration into the curriculum. The project presentation aims to provide orientation and action guidelines to facilitate similar processes in other faculties.

  2. The European standard series in 9 European countries, 2002/2003 -- first results of the European Surveillance System on Contact Allergies

    DEFF Research Database (Denmark)

    Uter, W; Hegewald, J; Aberer, W

    2005-01-01

    Since January 2001, the European Surveillance System on Contact Allergies (ESSCA), supported by European Union funding (contract QLK4-CT-2001-00343), has started to collect patch-test data. This comprises a standardized clinical history and the patch-test results using the European standard series...... observed. The prevalence of contact allergy to Myroxylon pereirae resin (balsam of Peru) (5.8%) is coming close to the frequency found with the fragrance mix (6.4%). Regarding contact allergy to chromium compounds, different frequencies were noted in the 2 centres focused on occupational dermatitis (2...

  3. Parametric Sensitivity Tests—European Polymer Electrolyte Membrane Fuel Cell Stack Test Procedures

    DEFF Research Database (Denmark)

    Araya, Samuel Simon; Andreasen, Søren Juhl; Kær, Søren Knudsen

    2014-01-01

    performed based on test procedures proposed by a European project, Stack-Test. The sensitivity of a Nafion-based low temperature PEMFC stack’s performance to parametric changes was the main objective of the tests. Four crucial parameters for fuel cell operation were chosen; relative humidity, temperature......, pressure, and stoichiometry at varying current density. Furthermore, procedures for polarization curve recording were also tested both in ascending and descending current directions....

  4. Standard Operating Procedures for Female Genital Sexual Pain

    DEFF Research Database (Denmark)

    Fugl-Meyer, Kerstin S; Bohm-Starke, Nina; Damsted Petersen, Christina

    2012-01-01

    and psychological disorders are highlighted, and different somatic and psychological assessment and treatment modalities are discussed. Methods.  The Standard Operating Procedures (SOP) committee was composed of a chair and five additional experts. No corporate funding or remuneration was received. The authors...... therapeutic interventions. However, this international expert group will recommend guidelines for management of female GSP. Conclusions.  GSP disorders are complex. It is recommended that their evaluation and treatment are performed through comprehensive somato-psychological multidisciplinary approach. Fugl......Introduction.  Female genital sexual pain (GSP) is a common, distressing complaint in women of all ages that is underrecognized and undertreated. Definitions and terminology for female GSP are currently being debated. While some authors have suggested that GSP is not per se a sexual dysfunction...

  5. Quality assurance: Importance of systems and standard operating procedures.

    Science.gov (United States)

    Manghani, Kishu

    2011-01-01

    It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality management. Quality control is focused on fulfilling quality requirements, whereas quality assurance is focused on providing confidence that quality requirements are fulfilled. The quality systems must be commensurate with the Company business objectives and business model. Top management commitment and its active involvement are critical in order to ensure at all times the adequacy, suitability, effectiveness and efficiency of the quality systems. Effective and efficient quality systems can promote timely registration of drugs by eliminating waste and the need for rework with overall financial and social benefits to the Company.

  6. Bargaining in the shadow of the European settlement procedure for cartels

    NARCIS (Netherlands)

    Schinkel, M.P.

    2011-01-01

    The article discusses the European Commission's legal settlement procedures regarding cartels, with emphasis given to its denial of plea bargaining bargaining and negotiation. The author argues that such a hard stance on settlements may actually have negative effects on cartelization deterrence

  7. Standard procedures for pooling health physics data for epidemiologic studies

    International Nuclear Information System (INIS)

    Strom, D.J.; Beck, W.L.; Stansbury, P.S.; Tankersley, W.G.; Watson, J.E. Jr.

    1983-01-01

    The objectives of the study are: (1) to determine the availability of dosimetry data and supporting documentation at multiple facilities; (2) to develop criteria and methods for optimally retrieving data; (3) to evaluate and document the quality and completeness of data and dosimetry programs; (4) to put dosimetry data (e.g., external, whole body counting, and bioassay data) from various facilities in a single format for epidemiologic analysis; and (5) to document all work for peer review. To achieve these objectives, a ''Dosimetry Records and Radiation Hazards Questionnaire'' was developed to send to the facilities under study. Responses to this questionnaire are used to develop data retrieval criteria and methods, and to retrieve data. Dose data are reformatted into Standard Intermediate Dosimetry Files for editing and characterization. Evaluations of dosimetry programs are performed concurrently. Results of these steps are brought together and analysis files created. Status of this work in the context of the Department of Energy 5-Rem Study is reported. The standard procedures are applicable to single- as well as multiple-facility studies

  8. Radiation protection in odontology: French regulation and new European standards

    International Nuclear Information System (INIS)

    Foucart, J.M.

    2004-01-01

    This a point on the regulatory evolutions in the field of radiation protection in the daily practice of odontology, consecutive to the transposition in French law of European directives. This work proposes practical cards to manage installation in radiodiagnosis in order to protect professional personnel and patients. (N.C.)

  9. Electoral rules in Serbia and the European standards on universal suffrage

    Directory of Open Access Journals (Sweden)

    Nastić Maja

    2014-01-01

    Full Text Available Elections are the most important form of citizens' participation in political decision-making processes in every state. Electoral rules shape the electoral democracy as an essential component of democracy. Elections are the basis for government legitimacy and the cornerstone of democracy, providing that they are organized on the following principles: universal and equal suffrage; free, personal and direct voting by secret ballot. The subject matter of this article is the principle of universal suffrage in the electoral rules in Serbia and its compliance with the European standards. The electoral legislation in Serbia is not homogeneous and it is contained in several legislative acts. The Act on the Election of Members of Parliament is the basic legislative act which regulates the matter of parliamentary elections. The Presidential and local elections are regulated by separate legislative acts, which (along with the Act on the Unified Register of Voters regulate the substantive and procedural framework of Serbian electoral law. Within the framework of European electoral standards, the author explores the relevant provisions of the European Convention for the Protection of Human Rights and Fundamental Freedoms (Article 3 of Protocol No. 1, the OSCE documents (primarily the Copenhagen Criteria and the Code of Good Practice in Electoral Matters, adopted by the Venice Commission. The author analyzes the national electoral rules and how they provide for the exercise of the principle of universal suffrage, i.e. the right of each citizen to vote and to stand for election, including the envisaged restrictions to this right. Bearing in mind that the universal suffrage right may be exercised only if the state ensures that the electoral register is regularly and efficiently updated, the author specifically focuses on the voters' registration. The exercise of the universal suffrage right will also be considered in terms of candidacy for an MP position. The

  10. Measuring and diagnosing unilateral neglect: a standardized statistical procedure.

    Science.gov (United States)

    Toraldo, Alessio; Romaniello, Cristian; Sommaruga, Paolo

    Unilateral neglect is usually investigated by adminstering stimuli (targets) in different positions, with targets being responded to by the patient (Hit) or omitted. In spite of this homogeneity of data type, neglect indices and diagnostic criteria vary considerably, causing inconsistencies in both clinical and experimental settings. We aimed at deriving a standard analysis which would apply to all tasks sharing this data form. A-priori theoretical reasoning demonstrated that the mean position of Hits in space (MPH) is an optimal index for correctly diagnosing and quantifying neglect. Crucially MPH eliminates the confounding effects of deficits that are different from neglect (non-lateral) but which decrease Hit rate. We ran a Monte Carlo study to assess MPH's (so far overlooked) statistical behavior as a function of numbers of targets and Hits. While average MPH was indeed insensitive to non-lateral deficits, MPH's variance (like that of all other neglect indices) increased dramatically with increasing non-lateral deficits. This instability would lead to alarmingly high false-positive rates (FPRs) when applying a classical diagnostic procedure that compares one patient with a control sample. We solved the problem by developing an equation that takes into account MPH instability and provides correct cut-offs and close-to-nominal FPRs, even without control subjects. We developed a computerized program which, given the raw data, yields the MPH, a z-score and a p-value. We provided a standard method that allows clinical and experimental neuropsychologists to diagnose and measure neglect in a consistent way across the vast majority of tasks.

  11. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections: The Rome Statements

    NARCIS (Netherlands)

    Mussini, C.; Antinori, A.; Bhagani, S.; Branco, T.; Brostrom, M.; Dedes, N.; Bereczky, T.; Girardi, E.; Gökengin, D.; Horban, A.; Lacombe, K.; Lundgren, J. D.; Mendao, L.; Mocroft, A.; Oprea, C.; Porter, K.; Podlekareva, D.; Battegay, M.; d'Arminio Monforte, A.; Mulcahy, Fiona; Geretti, Anna Maria; Clumeck, Nathan; Reiss, Peter; Arribas, Jose; Gatell, Jose; Katlama, Christine; Pozniak, Anton; Rockstroh, Jürgen; Youle, Mike; Friis-Møller, Nina; Rusconi, Stefano; Behrens, Georg; de Wit, Stéphane; Furrer, Hansjakob; Wensing, Annemarie; John Gill, M.; Letendre, Scott

    2016-01-01

    The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. Data-driven presentations were given on specific topics followed by interactive panel

  12. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections : The Rome Statements

    NARCIS (Netherlands)

    Mussini, C.; Antinori, A.; Bhagani, S.; Branco, T.; Brostrom, M.; Dedes, N.; Bereczky, T.; Girardi, E.; Gökengin, D.; Horban, A.; Lacombe, K.; Lundgren, J. D.; Mendao, L.; Mocroft, A.; Oprea, C.; Porter, K.; Podlekareva, D.; Battegay, M.; d'Arminio Monforte, A.; Mulcahy, Fiona; Geretti, Anna Maria; Clumeck, Nathan; Reiss, Peter; Arribas, Jose; Gatell, Jose; Katlama, Christine; Pozniak, Anton; Rockstroh, Jürgen; Youle, Mike; Friis-Møller, Nina; Rusconi, Stefano; Behrens, Georg; De Wit, Stéphane; Furrer, Hansjakob; Wensing, Annemarie|info:eu-repo/dai/nl/30817724X; John Gill, M.; Letendre, Scott

    2016-01-01

    Objectives: The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. Methods: Data-driven presentations were given on specific topics followed

  13. The European Court of Human Rights’ Use of Standard-Setting Council of Europe Documents

    NARCIS (Netherlands)

    Glas, L.R.

    2017-01-01

    In many judgments, the European Court of Human Rights (Court) lists relevant international materials and sometimes uses these documents when determining whether the European Convention on Human Rights has been violated. These materials are often standard-setting documents that originate in the

  14. Standard formatted data units-control authority procedures

    Science.gov (United States)

    1991-01-01

    The purpose of this document is to establish a set of minimum and optional requirements for the implementation of Control Authority (CA) organizations within and among the Agencies participating in the Consultative Committee for Space Data Systems (CCSDS). By satisfying these requirements, the resultant cooperating set of CA organizations will produce a global CA service supporting information transfer with digital data under the Standard Formatted Data Unit (SFDU) concept. This service is primarily accomplished through the registration, permanent archiving, and dissemination of metadata in the form of Metadata Objects (MDO) that assist in the interpretation of data objects received in SFDU form. This Recommendation addresses the responsibilities, services, and interface protocols for a hierarchy of CA organizations. The top level, consisting of the CCSDS Secretariat and its operational agent, is unique and primarily provides a global coordination function. The lower levels are Agency CA organizations that have primary responsibility for the registration, archiving, and dissemination of MDOs. As experience is gained and technology evolves, the CA Procedures will be extended to include enhanced services and their supporting protocols. In particular, it is anticipated that eventually CA organizations will be linked via networks on a global basis, and will provide requestors with online automated access to CA services. While this Recommendation does not preclude such operations, it also does not recommend the specific protocols to be used to ensure global compatibility of these services. These recommendations will be generated as experience is gained.

  15. Quality assurance: Importance of systems and standard operating procedures

    Directory of Open Access Journals (Sweden)

    Kishu Manghani

    2011-01-01

    Full Text Available It is mandatory for sponsors of clinical trials and contract research organizations alike to establish, manage and monitor their quality control and quality assurance systems and their integral standard operating procedures and other quality documents to provide high-quality products and services to fully satisfy customer needs and expectations. Quality control and quality assurance systems together constitute the key quality systems. Quality control and quality assurance are parts of quality management. Quality control is focused on fulfilling quality requirements, whereas quality assurance is focused on providing confidence that quality requirements are fulfilled. The quality systems must be commensurate with the Company business objectives and business model. Top management commitment and its active involvement are critical in order to ensure at all times the adequacy, suitability, effectiveness and efficiency of the quality systems. Effective and efficient quality systems can promote timely registration of drugs by eliminating waste and the need for rework with overall financial and social benefits to the Company.

  16. Manual of Standard Operating Procedures for Veterinary Drug Residue Analysis

    International Nuclear Information System (INIS)

    2016-01-01

    Laboratories are crucial to national veterinary drug residue monitoring programmes. However, one of the main challenges laboratories encounter is obtaining access to relevant methods of analysis. Thus, in addition to training, providing technical advice and transferring technology, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has resolved to develop clear and practical manuals to support Member State laboratories. The Coordinated Research Project (CRP) on Development of Radiometric and Allied Analytical Methods to Strengthen Residue Control Programs for Antibiotic and Anthelmintic Veterinary Drug Residues has developed a number of analytical methods as standard operating procedures (SOPs), which are now compiled here. This publication contains SOPs on chromatographic and spectrometric techniques, as well as radioimmunoassay and associated screening techniques, for various anthelmintic and antimicrobial veterinary drug residue analysis. Some analytical method validation protocols are also included. The publication is primarily aimed at food and environmental safety laboratories involved in testing veterinary drug residues, including under organized national residue monitoring programmes. It is expected to enhance laboratory capacity building and competence through the use of radiometric and complementary tools and techniques. The publication is also relevant for applied research on residues of veterinary drugs in food and environmental samples

  17. Global labour-standards advocacy by European civil society organisations: trends and developments

    NARCIS (Netherlands)

    Fransen, L.; Burgoon, B.

    2015-01-01

    In recent years, developments in intergovernmental organizations and transnational private governance organizations have created new opportunities and constraints for the promotion of global labour-standards governance by civil society organizations (CSOs). This article describes how European CSOs

  18. 49 CFR 1111.9 - Procedural schedule in cases using simplified standards.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 8 2010-10-01 2010-10-01 false Procedural schedule in cases using simplified... PROCEDURES § 1111.9 Procedural schedule in cases using simplified standards. (a) Procedural schedule. Absent a specific order by the Board, the following general procedural schedules will apply in cases using...

  19. Standardization of milk mid-infrared spectra from a European dairy network.

    Science.gov (United States)

    Grelet, C; Fernández Pierna, J A; Dardenne, P; Baeten, V; Dehareng, F

    2015-04-01

    The goal of this study was to find a procedure to standardize dairy milk mid-infrared spectra from different Fourier transform mid-infrared spectrophotometers (different brands or models) inside a European dairy network to create new farm-management indicators (e.g., fertility, health, feed, environmental impact) based on milk infrared spectra. This step is necessary to create common spectral databases, allowing the building of statistical tools, to be used by all instruments of the network. The method used was piecewise direct standardization (PDS), which matches slave-instrument spectra on master-instrument spectra. To evaluate the possibility of using common equations on different instruments, the PDS method was tested on a set of milk samples measured on each machine, and an equation predicting fat content of milk is applied on all. Regressions were performed between master and slaves fat predictions, before and after PDS. Bias and root mean square error between predictions were decreased after PDS, respectively, from 0.3781 to 0.0000 and from 0.4609 to 0.0156 (g of fat/100mL of milk). The stability over time of these results was confirmed by an application of the coefficients created by PDS 1 mo later on the slave spectra. These preliminary results showed that the PDS method permits a reduction of the inherent spectral variability between instruments, allowing the merging of Fourier transform mid-infrared milk spectra from different instruments into a common database, the creation of new types of dairy farm management indicators, and the use of these common calibrations for all Fourier transform mid-infrared instruments of the European dairy network. Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  20. Estimating the Standard Error of the Judging in a modified-Angoff Standards Setting Procedure

    Directory of Open Access Journals (Sweden)

    Robert G. MacCann

    2004-03-01

    Full Text Available For a modified Angoff standards setting procedure, two methods of calculating the standard error of the..judging were compared. The Central Limit Theorem (CLT method is easy to calculate and uses readily..available data. It estimates the variance of mean cut scores as a function of the variance of cut scores within..a judging group, based on the independent judgements at Stage 1 of the process. Its theoretical drawback is..that it is unable to take account of the effects of collaboration among the judges at Stages 2 and 3. The..second method, an application of equipercentile (EQP equating, relies on the selection of very large stable..candidatures and the standardisation of the raw score distributions to remove effects associated with test..difficulty. The standard error estimates were then empirically obtained from the mean cut score variation..observed over a five year period. For practical purposes, the two methods gave reasonable agreement, with..the CLT method working well for the top band, the band that attracts most public attention. For some..bands in English and Mathematics, the CLT standard error was smaller than the EQP estimate, suggesting..the CLT method be used with caution as an approximate guide only.

  1. International standards and quality control procedures applied to nuclear instruments

    International Nuclear Information System (INIS)

    Urbanski, P.

    2008-01-01

    The survey of international standards related to Nuclear Instrumentation and QC tests was presented. From among the 29'336 active international standards published by such organizations as ISO, IEC, CEN and CENELEC, only 582 are devoted to nuclear instruments. The international classification of standards (ICS) is shown. Also, the list of 582 international standards related to nuclear instruments is attached. (author)

  2. Standardization of Gleason grading among 337 European pathologists

    DEFF Research Database (Denmark)

    Egevad, Lars; Ahmad, Amar S; Algaba, Ferran

    2013-01-01

    AIMS:   The 2005 International Society of Urological Pathology (ISUP) modification of Gleason grading recommended that the highest grade should always be included in the Gleason score (GS) in prostate biopsies. We analysed the impact of this recommendation on reporting of GS 6 versus 7. METHODS...... AND RESULTS:   Fifteen expert uropathologists reached two-thirds consensus on 15 prostate biopsies with GS 6-7 cancer. Eighty-five microphotographs were graded by 337 of 617 members of the European Network of Uropathology (ENUP), representing 19 countries. There was agreement between expert and majority...... member GS in 12 of 15 cases, while members upgraded in three cases. Among members and the expert consensus, a GS >6 was assigned by 64.5% and 60%, respectively. Mean member GS was higher than consensus GS in nine of 15 cases. A Gleason pattern (GP) 5 was reported by 0.3-5.6% in 10 cases. Agreement...

  3. Investigation of reference levels and radiation dose associated with abdominal EVAR (endovascular aneurysm repair) procedures across several European Centres

    Energy Technology Data Exchange (ETDEWEB)

    Tuthill, E.; Rainford, L. [University College Dublin, Diagnostic Imaging, School of Medicine, Dublin (Ireland); O' Hora, L.; O' Donohoe, M. [Mater Misericordiae University Hospital, Dublin (Ireland); Panci, S. [San Giovanni di Dio Hospital, Florence (Italy); Gilligan, P.; Fox, E. [Mater Private Hospital, Dublin (Ireland); Campion, D. [Mauriziano-Umberto Hospital, Turin (Italy); Trenti, R. [Policlinico S. Orsola-Malpighi, Bologna (Italy); Catania, D. [AITRI, Association of Italian Interventional Radiographers, Milan (Italy)

    2017-11-15

    Endovascular aneurysm repair (EVAR) is considered the treatment of choice for abdominal aortic aneurysms with suitable anatomy. In order to improve radiation safety, European Directive (2013/59) requires member states to implement diagnostic reference levels (DRLs) in radio-diagnostic and interventional procedures. This study aimed to determine local DRLs for EVAR across five European centres and identify an interim European DRL, which currently remains unestablished. Retrospective data was collected for 180 standard EVARs performed between January 2014 and July 2015 from five specialist centres in Ireland (n=2) and Italy (n=3). Data capture included: air kerma-area product (P{sub KA}), total air kerma at the reference point (K{sub a,r}), fluoroscopic time (FT), number of acquisitions, frame rate of acquisition, type of acquisition, patient height, weight, and gender. The mean values for each site A, B, C, D, and E were: P{sub KA}s of 4343 ± 994 μGym{sup 2}, 18,200 ± 2141 μGym{sup 2}, 11,423 ± 1390 μGym{sup 2}, 7796 ± 704 μGym{sup 2}, 31,897 ± 5798 μGym{sup 2}; FTs of 816 ± 92 s, 950 ± 150 s, 708 ± 70 s, 972 ± 61 s, 827 ± 118 s; and number of acquisitions of 6.72 ± 0.56, 10.38 ± 1.54, 4.74 ± 0.19, 5.64 ± 0.36, 7.28 ± 0.65, respectively. The overall pooled 75th percentile P{sub KA} was 15,849 μGym{sup 2}. Local reference levels were identified. The pooled data has been used to establish an interim European DRL for EVAR procedures. (orig.)

  4. International laser safety standardization. From the European perspective with an emphasis on materials processing

    International Nuclear Information System (INIS)

    Schulmeister, K.

    1997-08-01

    This report reviews international standards relevant to the safety of laser products and laser installations, with an emphasis on the safety of laser materials processing from the European perspective. In the first paragraphs an overview of the international standards organisations, their relative roles and ways of developing new standards is given. In the second part of the report, work currently underway in the respective standards committees is summarised and specific standards dealing with different aspects of laser safety are discussed. An appendix contains a list of standards organised in standards organisations IEC, ISO and EN). (author)

  5. European wind turbine testing procedure developments. Task 1: Measurement method to verify wind turbine performance characteristics

    DEFF Research Database (Denmark)

    Hunter, R.; Friis Pedersen, Troels; Dunbabin, P.

    2001-01-01

    There is currently significant standardisation work ongoing in the context of wind farm energy yield warranty assessment and wind turbine power performance testing. A standards maintenance team is revising the current IEC (EN) 61400-12 Ed 1 standard forwind turbine power performance testing...... standard. The work was wide ranging and addressed 'grey' areas of knowledge, regarding existing methodologies or to carry out basic research in support offundamentally new procedures. The work has given rise to recommendations in all areas of the work, including site calibration procedures, nacelle...

  6. European standards for the biofuels; Des normes europeennes pour les biocombustibles

    Energy Technology Data Exchange (ETDEWEB)

    Alakangas, E. [VTT Processes, Energy Production (Finland)

    2004-03-01

    The European Committee of Standardization is writing about 30 technical specifications concerning the solid biofuels, in order to promote the marketing of biofuels based on standards which define objectively the solid biofuels quality. Finland is managing the redaction of these technical descriptions for the definition of fuels specifications, class and quality assurance. (A.L.B.)

  7. Principality of Serbia on the road towards European monetary standards

    Directory of Open Access Journals (Sweden)

    Gnjatović Dragana

    2015-01-01

    Full Text Available In 1868, after more than four centuries, the Principality of Serbia decided to rebuild national monetary system in line with the minting standards of the Latin Monetary Union. The paper explains the international circumstances in which this decision was made and analyzes a specific plan created for the implementation of monetary reform. Because of the general shortage of small coins in circulation, Serbia decided firstly to mint domestic copper and small silver coins, and subsequently larger denominations of silver and gold coins. The research is based on archival documents of the State Council of the Principality of Serbia that are kept in the Archives of Serbia in Belgrade.

  8. Standard interface files and procedures for reactor physics codes. Version IV

    International Nuclear Information System (INIS)

    O'Dell, R.D.

    1977-09-01

    Standards, procedures, and recommendations of the Committee on Computer Code Coordination for promoting the exchange of reactor physics codes are updated to Version IV status. Standards and procedures covering general programming, program structure, standard interface files, and file management and handling subroutines are included

  9. INTERNATIONAL FINANCIAL REPORTING STANDARD FOR SMALL AND MEDIUM-SIZED ENTITIES- A NEW CHALLENGE FOR THE EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    Ana-Maria Pascu

    2011-03-01

    Full Text Available In the context of the global economic crisis, small and medium enterprises are most affected. That is why the problem that arises more frequently is the harmonization of national legislation with the European legislation. The necessity to implement specific standards for SMEs appeared in order to provide them a beneficial framework for better economic and financial market positioning. In this respect, the International Accounting Standards Board issued in 2009 IFRS for SMEs, a referential aiming to the simplification of accounting procedures, reconciliation and increase of confidence of potential investors (stakeholders. The question of compatibility of these standards with the European Accounting Directives appears in situations where they may choose to use IFRS for SMEs. The aim of this paper is to evaluate the incompatibilities between IFRS for SMEs and the European Accounting Directives and to analyze the results concerning the implementation of the IFRS for SMEs in Europe. Through this article we want to contribute to the SME accounting area of knowledge.

  10. Manual for the GAW Precipitation Chemistry Programme: Guidelines, Data Quality Objectives and Standard Operating Procedures

    National Research Council Canada - National Science Library

    Allan, Mary A

    2004-01-01

    This is a manual for the Global Atmosphere Watch Precipitation Chemistry (GAW-PC) Programme. Where possible, it describes standard operating procedures and otherwise provides guidance on methods and procedures...

  11. Standardization of the time for the execution of HANARO start-up and shutdown procedures

    International Nuclear Information System (INIS)

    Choi, H. Y.; Lim, I. C.; Hwang, S. R.; Kang, T. J.; Youn, D. B.

    2003-01-01

    For the standardization of the time to execute HANARO start-up and shutdown procedures, code names were assigned to the individual procedures and the work time were investigated. The data recorded by the operators during start-up and shutdown were statistically analyzed. The analysis results will be used for the standardization of start-up and shutdown procedures and it will be reflected in the procedure document

  12. The Cardiology Audit and Registration Data Standards (CARDS), European data standards for clinical cardiology practice

    NARCIS (Netherlands)

    M.R. Flynn (Rachel); C. Barrett (Conor); F.G. Cosio (Francisco); A.K. Gitt (Anselm); L.C. Wallentin (Lars); P. Kearney (Peter); M. Lonergan (Moira); E. Shelley (Emer); M.L. Simoons (Maarten)

    2005-01-01

    textabstractAIMS: Systematic registration of data from clinical practice is important for clinical care, local, national and international registries, and audit. Data to be collected for these different purposes should be harmonized. Therefore, during Ireland's Presidency of the European Union (EU)

  13. 21 CFR 606.100 - Standard operating procedures.

    Science.gov (United States)

    2010-04-01

    ... blood and blood components for transfusion and further manufacturing purposes. Such procedures shall be... the site of phlebotomy to give maximum assurance of a sterile container of blood. (4) Method of... precautions taken to measure accurately the quantity of blood removed from the donor. (6) Methods of component...

  14. Creating Royal Australian Navy Standard Operating Procedures using Flow Diagrams

    Science.gov (United States)

    2015-08-01

    set it is important to determine writing and approval responsibilities, storage methods and publishing details before SOPs are written. This...5 4.1.1 Brainstorming ...managed accordingly. Key activities include scoping the set of SOPs, creating a team, developing a plan, writing , reviewing and approving procedures, and

  15. Item Disordinality with the Bookmark Standard Setting Procedure.

    Science.gov (United States)

    Skaggs, Gary; Tessema, Aster

    This paper presents an application of the bookmark procedure to a test comprised of increasing text difficulty levels. The Test of English Proficiency for Adults (TEPA) was used for this study. Three forms of the TEPA were field tested in 1999 with approximately 1,000 non-native English speaking students enrolled in English-as-a-Second-Language…

  16. Policy, Procedures and Standards for Enterprise Information Management

    Science.gov (United States)

    This policy establishes a standard approach for managing information produced by, funded by, or received per regulated reporting and/or federal-wide requirements and subsequently held or cataloged in information management systems by EPA.

  17. Standard Operating Procedure for Accelerated Corrosion Testing at ARL

    Science.gov (United States)

    2017-11-01

    to scribe nonferrous materials so as to prevent contamination of the substrate during the process. The "X" scribe is made by scribing 2 intersecting...may include GMW14872 Cyclic Corrosion Testing (typically Exterior, Exposure C), ASTM B117 Neutral Salt Fog Testing, ASTM G50 Atmospheric Corrosion...using the same cleaning procedures, contamination of the substrate is minimized during the scribe process. All partners adhering to guidelines and

  18. Standardization of the Romanowsky staining procedure: an overview.

    Science.gov (United States)

    Bentley, S A; Marshall, P N; Trobaugh, F E

    1980-01-01

    Commerically available Romanowsky blood stains are variable mixtures of thiazein dyes and brominated fluorescein derivatives with varying degrees of metallic salt contamination in a number of different solvent systems. There is a need for standardized Romanowsky stains of constant composition, which, when used in conjunction with a carefully controlled specimen preparation technique, should give consistent performance. Such a preparation system would be of great value to hematologists in general and would be essential to the validity of data obtained by the digital processing of blood cell images. It is possible to prepare standardized Romanowsky stains as mixtures of two or three dye components, namely, eosin Y, azure B and methylene blue, although azure B has only recently become commercially available at an acceptable degree of purity. The logistic problems of stain standardization are discussed.

  19. Planning and evaluating prescribed fires--a standard procedure

    Science.gov (United States)

    William C. Fischer

    1978-01-01

    Provides a standard format and checklist to guide the land manager through the important steps for prescribed burning. Describes the kind of information needed to prepare fire prescriptions and burning plans. Identifies the elements of a fire prescription, a burning plan, and a prescribed fire evaluation. A plan written for an actual prescribed burning is included as...

  20. Standardized Procedures for Use of Nucleic Acid-Based Tools

    Science.gov (United States)

    2008-08-01

    Madigan, M., J. Martinko, P. Dunlap and D. Clark (2006). Brock Biology Of Microorganisms , Benjamin Cummings. Mailloux, B. J. and M. E. Fuller...Methods for Enumeration of Microorganisms and Development of a Dhc Reference Standard...Dehalococcoides (Dhc) and other environmentally relevant microorganisms . The results of these analyses are increasingly used by site owners

  1. 12 CFR 616.6300 - Leasing policies, procedures, and underwriting standards.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Leasing policies, procedures, and underwriting standards. 616.6300 Section 616.6300 Banks and Banking FARM CREDIT ADMINISTRATION FARM CREDIT SYSTEM LEASING § 616.6300 Leasing policies, procedures, and underwriting standards. The board of each institution...

  2. 7 CFR 201.67 - Seed certifying agency standards and procedures.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 3 2010-01-01 2010-01-01 false Seed certifying agency standards and procedures. 201...) FEDERAL SEED ACT FEDERAL SEED ACT REGULATIONS Certified Seed § 201.67 Seed certifying agency standards and procedures. In order to qualify as a seed certifying agency for purposes of section 101(a)(25) of the Federal...

  3. Procedures and Standards Handbook. Version 3.0. What Works Clearinghouse

    Science.gov (United States)

    What Works Clearinghouse, 2014

    2014-01-01

    This "What Works Clearinghouse Procedures and Standards Handbook (Version 3.0)" provides a detailed description of the standards and procedures of the What Works Clearinghouse (WWC). The remaining chapters of this Handbook are organized to take the reader through the basic steps that the WWC uses to develop a review protocol, identify…

  4. A Comparison of Standard-Setting Procedures for an OSCE in Undergraduate Medical Education.

    Science.gov (United States)

    Kaufman, David M.; Mann, Karen V.; Muijtjens, Arno M. M.; van der Vleuten, Cees P. M.

    2000-01-01

    Compared four standard-setting procedures for an objective structure clinical examination (OSCE) in medical education. Applied Angoff, borderline, relative, and holistic procedures to the data used to establish a cutoff score for a pass/fail decision. The Angoff and borderline procedures gave similar results; however, the relative and holistic…

  5. Recommendations to reduce hand exposure for standard nuclear medicine procedures

    International Nuclear Information System (INIS)

    Sans-Merce, M.; Ruiz, N.; Barth, I.; Carnicer, A.; Donadille, L.; Ferrari, P.; Fulop, M.; Ginjaume, M.; Gualdrini, G.; Krim, S.; Mariotti, F.; Ortega, X.; Rimpler, A.; Vanhavere, F.; Baechler, S.

    2011-01-01

    The optimization of the extremity dosimetry of medical staff in nuclear medicine was the aim of the Work Package 4 (WP4) of the ORAMED project, a Collaborative Project (2008–2011) supported by the European Commission within its 7th Framework Programme. Hand doses and dose distributions across the hands of medical staff working in nuclear medicine departments were evaluated through an extensive measurement program involving 32 hospitals in Europe and 139 monitored workers. The study included the most frequently used radionuclides, 99m Tc- and 18 F-labelled radiopharmaceuticals for diagnostic and 90 Y-labelled Zevalin ® and DOTATOC for therapy. Furthermore, Monte Carlo simulations were performed in different predefined scenarios to evaluate separately the efficacy of different radiation protection measures by comparing hand dose distributions according to various parameters. The present work gives recommendations based on results obtained with both measurements and simulations. This results in nine practical recommendations regarding the positioning of the dosemeters for an appropriate skin dose monitoring and the best protection means to reduce the personnel exposure.

  6. Operational procedure standard for occurrences involving radioactive materials

    Energy Technology Data Exchange (ETDEWEB)

    Piekarz, Leonardo, E-mail: leonardopbm@yahoo.com.br [Academia de Bombeiros Militar de Minas Gerais, Belo Horizonte, MG (Brazil); Rezende, Talita C.; Pinheiro, Christiano J.G., E-mail: talitacolombi@yahoo.com, E-mail: christrieste@yahoo.it [Universidade Federal do Espirito Santo (CCA/UFES), Alegre, ES (Brazil). Programa de Pós-Graduação em Engenharia Química

    2017-07-01

    This study has as objective to analyze more deeply the actions of response to emergencies involving radioactive materials, in the intent to establish a pattern to the actions performed by the military fire fighters of the Military Fire Brigade of Minas Gerais. To met these goals, it has been attempted to analyze the procedures utilized and recommended, nowadays, for the military fire fighters of CBMMG, and through directed studies, to suggest new actions possible to be executed in the local of the emergency in a way that will not expose the garrison to doses of ionizing radiation that may prejudice them. It is a study of bibliographic, exploratory, and also descriptive nature, realized through a qualitative approach. The techniques used for the research were the analysis of institutional documents, norms and other literature produced by renamed entities in the radiologic and biosafety areas. It was then concluded that CBMMG, through simple actions of response, can provide higher quality and safety in the operations involving radiologic accidents, standing out that the implemented actions nowadays are very beneath the capacity of the corporation, due to the lack of knowledge of the matter by the fire fighters. It was proposed, then, that new actions be implemented and instituted as operational procedures to be used on those emergencies, with the objective of provide a higher safety and professionalism in the attendance to emergencies involving radioactive materials. (author)

  7. Operational procedure standard for occurrences involving radioactive materials

    International Nuclear Information System (INIS)

    Piekarz, Leonardo; Rezende, Talita C.; Pinheiro, Christiano J.G.

    2017-01-01

    This study has as objective to analyze more deeply the actions of response to emergencies involving radioactive materials, in the intent to establish a pattern to the actions performed by the military fire fighters of the Military Fire Brigade of Minas Gerais. To met these goals, it has been attempted to analyze the procedures utilized and recommended, nowadays, for the military fire fighters of CBMMG, and through directed studies, to suggest new actions possible to be executed in the local of the emergency in a way that will not expose the garrison to doses of ionizing radiation that may prejudice them. It is a study of bibliographic, exploratory, and also descriptive nature, realized through a qualitative approach. The techniques used for the research were the analysis of institutional documents, norms and other literature produced by renamed entities in the radiologic and biosafety areas. It was then concluded that CBMMG, through simple actions of response, can provide higher quality and safety in the operations involving radiologic accidents, standing out that the implemented actions nowadays are very beneath the capacity of the corporation, due to the lack of knowledge of the matter by the fire fighters. It was proposed, then, that new actions be implemented and instituted as operational procedures to be used on those emergencies, with the objective of provide a higher safety and professionalism in the attendance to emergencies involving radioactive materials. (author)

  8. Education and training requirements in the revised European Basic Safety Standards Directive

    International Nuclear Information System (INIS)

    Mundigl, S.

    2009-01-01

    The European Commission is currently developing a modified European Basic Safety Standards Directive covering two major objectives: the consolidation of existing European Radiation Protection legislation, and the revision of the European Basic Safety Standards. The consolidation will merge the following five Directives into one single Directive: the Basic Safety Standards Directive, the Medical Exposures Directive, the Public Information Directive, the Outside Workers Directive, and the Directive on the Control of high-activity sealed radioactive sources and orphan sources. The revision of the European Basic Safety Standards will take account of the latest recommendations by the International Commission on Radiological Protection (ICRP) and shall improve clarity of the requirements where appropriate. It is planned to introduce more binding requirements on natural radiation sources, on criteria for clearance, and on the cooperation between Member States for emergency planning and response, as well as a graded approach for regulatory control. One additional goal is to achieve greater harmonisation between the European BSS and the international BSS. Following a recommendation from the Article 31 Group of Experts, the current draft of the modified BSS will highlight the importance of education and training by dedicating a specific title to radiation protection education, training and information. This title will include a general requirement on the Member States to ensure the establishment of an adequate legislative and administrative framework for providing appropriate radiation protection education, training and information. In addition, there will be specific requirements on training in the medical field, on information and training of workers in general, of workers potentially exposed to orphan sources, and to emergency workers. The revised BSS directive will include requirements on the competence of a radiation protection expert (RPE) and of a radiation protection

  9. Standard contract terms regulation in the proposal for a common European sales law

    NARCIS (Netherlands)

    Loos, M.B.M.

    2012-01-01

    In this paper, the regulation in standard contract terms in the proposal for a Commono European Sales Law (CESL) is compared with the regulation in the Unfair Terms Directive, the Draft Common Frame of Reference (DCFR) and the Vienna Sales Convention (CISG). The paper starts with an overview of the

  10. European AIDS Clinical Society Second Standard of Care Meeting, Brussels 16-17 November 2016

    DEFF Research Database (Denmark)

    De Wit, S; Battegay, M; D'Arminio Monforte, A

    2018-01-01

    The European AIDS Clinical Society (EACS) organized a second meeting on Standard of Care in Europe on November 16-17 th, 2016. The aims of the meeting were to discuss and propose actions on three topics, namely: Adherence to guidelines for treatment initiation, treatment monitoring and outcomes, ...

  11. The distinct politics of the European Union’s 'fair trade' linkage to labour standards

    NARCIS (Netherlands)

    Burgoon, B.

    2009-01-01

    European Union (EU) social actors, governments and EU level representatives have been divided over fair trade linkage, where trade access is made conditional upon protection of labour standards. This division is partly an artefact of sharp disagreement and confusion over the nature of such linkage:

  12. Implementation and translation: from European standards and guidelines for quality assurance to education quality work in higher education institutions

    NARCIS (Netherlands)

    Westerheijden, Donald F.; Kohoutek, Jan; Eggins, Heather

    2014-01-01

    The Standards and Guidelines for Quality Assurance in the European Higher Education Area (ESG for short) have been part of the regulative infrastructure of the European Higher Education Area (EHEA) since 2005 (European Association for Quality Assurance in Higher Education, 2009).

  13. Muscle sparing lateral thoracotomy: the standard incision for thoracic procedures

    Directory of Open Access Journals (Sweden)

    Mihai Dumitrescu

    2017-05-01

    Full Text Available Lateral thoracotomy is a versatile approach with many variations and is currently the most widely used incision in thoracic surgery. In the current article we are presenting the muscle-sparing lateral thoracotomy in the lateral decubitus position which we consider to be the “standard” for lateral thoracotomies. Indications, surgical technique and pitfalls are described alongside our experience with thoracic drainage. Although there is no consensus regarding the name of this incision, some authors call it “axillary thoracotomy” while others call it a “modified lateral thoracotomy”, they all agree on one aspect – the importance of muscle sparing – which makes it the go-to thoracotomy for both small and large procedures involving the lung. Lateral muscle sparing thoracotomy allows for good exposure of the pulmonary hilum, fissures, apex and diaphragm. The approach is easy and quick to perform while at the same time ensuring faster postoperative recovery by sparing the latissimus dorsi muscle, better cosmetics and lower postoperative pain score when compared to the posterolateral or classical lateral thoracotomies.

  14. Standard-C hydrogen monitoring system acceptance test procedure

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, T.C.

    1994-09-02

    The primary function of the standard-C hydrogen monitoring system (SHMS) is to monitor specifically for hydrogen in the waste tank atmosphere which may also contain (but not be limited to) unknown quantities of air, nitrous oxide, ammonia, water vapor, carbon dioxide, carbon monoxide, and other gaseous constituents. The SHMS will consist of hydrogen specific monitors, a grab sampler to collect samples for laboratory analysis, a gas chromatograph, and the gas sample collection system necessary to support the operation of the instrumentation. This system will be located in a cabinet placed at the tank of interest. The purpose of this document is to demonstrate that the SHMS is constructed as intended by design.

  15. First-In-Man Procedural Experience with the Novel EmboTrap® Revascularization Device for the Treatment of Ischemic Stroke-A European Multicenter Series

    DEFF Research Database (Denmark)

    Kabbasch, C; Mpotsaris, A; Liebig, T

    2016-01-01

    -artery occlusion were treated in five European centers. Clinical and procedural data were collected; self-reported angiographic results and neurologic outcome (discharge and 90 days) were assessed in a standardized manner. RESULTS: The median National Institutes of Health Stroke Scale at admittance was 16.......8, with a mean procedural time to reperfusion of 54 min. One patient (2.5 %), who had not received IVT, experienced symptomatic intracranial hemorrhage post-interventionally. Procedural complications were encountered in 2 of 40 cases (5 %); both patients exhibited ICA dissection that was treated conservatively...... without clinical sequelae. There were no device-related complications. Of 23 available patients, 8 (35 %) had a good outcome after 90 days. CONCLUSION: The procedural results from these five centers suggest that EmboTrap is technically safe. Successful recanalization rates can be expected to be within...

  16. 78 FR 14010 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-03-04

    ...). Issued in Washington, DC, on February 15, 2013. John M. Allen, Director, Flight Standards Service..., RNAV (GPS) RWY 36, Orig Siren, WI, Burnett County, Takeoff Minimums and Obstacle DP, Orig BILLING CODE...

  17. 75 FR 63712 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-10-18

    ... 1, 2010. John M. Allen, Director, Flight Standards Service. Adoption of the Amendment 0 Accordingly..., Takeoff Minimums and Obstacle DP, Amdt 3 Siren, WI, Burnett County, VOR OR GPS RWY 5, Amdt 2B Solon...

  18. 76 FR 40600 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2011-07-11

    ... Navigation (air). Issued in Washington, DC, on June 24, 2011. John M. Allen, Director, Flight Standards... Corinth, MS, Roscoe Turner, RNAV (GPS) RWY 36, Amdt 1 Harvey, ND, Harvey Muni, RNAV (GPS) RWY 29, Orig-A...

  19. 75 FR 25760 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-05-10

    .... John M. Allen, Director, Flight Standards Service. Adoption of the Amendment 0 Accordingly, pursuant to... Muni, Takeoff Minimums and Obstacle DP, Amdt 3 Galliano, LA, South Lafourche Leonard Miller Jr, LOC/DME...

  20. 75 FR 9098 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2010-03-01

    ... 19, 2010. John M. Allen, Director, Flight Standards Service. Adoption of the Amendment 0 Accordingly... GALLIANO SOUTH LAFOURCHE 0/3269 2/3/10 RNAV (GPS) RWY 18, AMDT 1. LEONARD MILLER JR. 8-Apr-10 LA JENNINGS...

  1. 16 CFR 1610.35 - Procedures for testing special types of textile fabrics under the standard.

    Science.gov (United States)

    2010-01-01

    ... textile fabrics under the standard. 1610.35 Section 1610.35 Commercial Practices CONSUMER PRODUCT SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY OF CLOTHING TEXTILES Rules and Regulations § 1610.35 Procedures for testing special types of textile fabrics under the standard. (a) Fabric...

  2. Notes on the Particulate Matter Standards in the European Union and the Netherlands

    Directory of Open Access Journals (Sweden)

    Hugo Priemus

    2009-03-01

    Full Text Available The distribution of Particulate Matter in the atmosphere, resulting from emissions produced by cars, trucks, ships, industrial estates and agricultural complexes, is a topical public health problem that has increased in recent decades due to environmental factors in advanced economies in particular. This contribution relates the health impact caused by concentrations of Particulate Matter (PM in ambient air to the PM standards, the size of the particles and spatial planning. Diverging impacts of PM standards in legal regulation are discussed. The authors present a review of the development of legal PM standards in the European Union, with a specific reference to The Netherlands.

  3. Standardization of figures and assessment procedures for DTM verticalaccuracy

    Directory of Open Access Journals (Sweden)

    Vittorio Casella

    2015-07-01

    Full Text Available Digital Terrain Models (DTMs are widely used in many sectors. They play a key role in hydrological risk prevention, risk mitigation and numeric simulations. This paper deals with two questions: (i when it is stated that a DTM has a given vertical accuracy, is this assertion univocal? (ii when DTM vertical accuracy is assessed by means of checkpoints, does their location influence results? First, the paper illustrates that two vertical accuracy definitions are conceivable: Vertical Accuracy at the Nodes (VAN, the average vertical distance between the model and the terrain, evaluated at the DTM's nodes and Vertical Accuracy at the interpolated Points (VAP, in which the vertical distance is evaluated at the generic points. These two quantities are not coincident and, when they are calculated for the same DTM, different numeric values are reached. Unfortunately, the two quantities are often interchanged, but this is misleading. Second, the paper shows a simulated example of a DTM vertical accuracy assessment, highlighting that the checkpoints’ location plays a key role: when checkpoints coincide with the DTM nodes, VAN is estimated; when checkpoints are randomly located, VAP is estimated, instead. Third, an in-depth, theoretical characterization of the two considered quantities is performed, based on symbolic computation, and suitable standardization coefficients are proposed. Finally, our discussion has a well-defined frame: it doesn't deal with all the items of the DTM vertical accuracy budget, which would require a much longer essay, but only with one, usually called fundamental vertical accuracy.

  4. Statistics on the use of cardiac electronic devices and electrophysiological procedures in the European Society of Cardiology countries: 2014 report from the European Heart Rhythm Association.

    Science.gov (United States)

    Raatikainen, M J Pekka; Arnar, David O; Zeppenfeld, Katja; Merino, Jose Luis; Levya, Francisco; Hindriks, Gerhardt; Kuck, Karl-Heinz

    2015-01-01

    There has been large variations in the use of invasive electrophysiological therapies in the member countries of the European Society of Cardiology (ESC). The aim of this analysis was to provide comprehensive information on cardiac implantable electronic device (CIED) and catheter ablation therapy trends in the ESC countries over the last five years. The European Heart Rhythm Association (EHRA) has collected data on CIED and catheter ablation therapy since 2008. Last year 49 of the 56 ESC member countries provided data for the EHRA White Book. This analysis is based on the current and previous editions of the EHRA White Book. Data on procedure rates together with information on economic aspects, local reimbursement systems and training activities are presented for each ESC country and the five geographical ESC regions. In 2013, the electrophysiological procedure rates per million population were highest in Western Europe followed by the Southern and Northern European countries. The CIED implantation and catheter ablation rate was lowest in the Eastern European and in the non-European ESC countries, respectively. However, in some Eastern European countries with relative low gross domestic product procedure rates exceeded those of some wealthier Western countries, suggesting that economic resources are not the only driver for utilization of arrhythmia therapies. These statistics indicate that despite significant improvements, there still is considerable heterogeneity in the availability of arrhythmia therapies across the ESC area. Hopefully, these data will help identify areas for improvement and guide future activities in cardiac arrhythmia management. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  5. The EPIC nutrient database project (ENDB): a first attempt to standardize nutrient databases across the 10 European countries participating in the EPIC study

    DEFF Research Database (Denmark)

    Slimani, N.; Deharveng, G.; Unwin, I.

    2007-01-01

    Objective: This paper describes the ad hoc methodological concepts and procedures developed to improve the comparability of Nutrient databases ( NDBs) across the 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition ( EPIC). This was required...... because there is currently no European reference NDB available. Design: A large network involving national compilers, nutritionists and experts on food chemistry and computer science was set up for the 'EPIC Nutrient DataBase' ( ENDB) project. A total of 550-1500 foods derived from about 37 000...... standardized EPIC 24-h dietary recalls (24-HDRS) were matched as closely as possible to foods available in the 10 national NDBs. The resulting national data sets ( NDS) were then successively documented, standardized and evaluated according to common guidelines and using a DataBase Management System...

  6. Containment integrity and leak testing. Procedures applied and experiences gained in European countries

    International Nuclear Information System (INIS)

    1987-01-01

    Containment systems are the ultimate safety barrier for preventing the escape of gaseous, liquid and solid radioactive materials produced in normal operation, not retained in process systems, and for keeping back radioactive materials released by system malfunction or equipment failure. A primary element of the containment shell is therefore its leak-tight design. The report describes the present containment concepts mostly used in European countries. The leak-testing procedures applied and the experiences gained in their application are also discussed. The report refers more particularly to pre-operational testing, periodic testing and extrapolation methods of leak rates measured at test conditions to expected leak rates at calculated accident conditions. The actual problems in periodic containment leak rate testing are critically reviewed. In the appendix to the report a summary is given of the regulations and specifications applied in different member countries

  7. Preparatory procedure and equipment for the European x-ray free electron laser cavity implementation

    Directory of Open Access Journals (Sweden)

    D. Reschke

    2010-07-01

    Full Text Available The European x-ray free electron laser is under construction at Deutsches Elektronen-Synchrotron (DESY. The electron beam energy of up to 17.5 GeV will be achieved by using superconducting accelerator technology. Final prototyping, industrialization, and new infrastructure are the actual challenges with respect to the accelerating cavities. This paper describes the preparation strategy optimized for the cavity preparation procedure in industry. For the industrial fabrication and preparation, several new hardware components have been already developed at DESY. The design and construction of a semiautomated rf-measurement machine for dumbbells and end groups are described. In a collaboration among FNAL, KEK, and DESY, an automatic cavity tuning machine has been designed and four machines are under construction. The functionality of these machines with special attention to safety aspects is described in this paper. A new high pressure rinsing system has been developed and is operational.

  8. The new european standard on common cements specifications EN 197-1:2011

    Directory of Open Access Journals (Sweden)

    Sanjuán, M. A.

    2012-09-01

    Full Text Available In this paper, the novelties of European standard EN 197-1:2011 which has been aprobed on 6th August, 2011 are presented. The european standard EN 197-1:2011 has been published in the Official Journal of the European Union on 19th June, 2012 (C 176/1. The UNEEN 197-1:2011 will be published in Spain in the Official Journal of Spain (B.O.E.. The date of applicability (DAV of the standard as a harmonised European standard is on 1st of July, 2012 and the date of the end of the coexistence period is on 1st of July, 2013. The former EN 197-1:2000 has been the first European standard in the field of the Construction Products Directive (CPD and this first revision include the requirements needed for a common cement to be, in addition, sulphate resisting cement. Therefore, the mandate given by the European Commission to CEN to prepare harmonised standards in the cement field (mandate M114 has been fulfilled.En este artículo se presentan las novedades de la nueva norma europea de especificaciones de cementos comunes UNE-EN 197-1:2011 aprobada el 6 de agosto de 2011 como EN 197-1:2011 y publicada el 19 de junio de 2012 en el Diario Oficial de la Unión Europea (DOUE. Esta norma se publicará en el Boletín Oficial del Estado (BOE antes de final de año. La fecha de disponibilidad (date of applicability, DAV es el 1 de julio de 2012 y el periodo de coexistencia finalizará el 1 de julio de 2013. La UNE-EN 197-1:2000 fue la primera norma armonizada dentro del campo de la Directiva de Productos de la Construcción (DPC europea y esta primera revisión incorpora unos nuevos requisitos para establecer cuándo un cemento común, además, es resistente a la acción de los sulfatos. De esta forma, se completa el mandato dado por la Comisión Europea a CEN para la elaboración de normas armonizadas de cementos (mandato M114.

  9. European AIDS Clinical Society Standard of Care meeting on HIV and related coinfections

    DEFF Research Database (Denmark)

    Mussini, C; Antinori, A; Bhagani, S

    2016-01-01

    OBJECTIVES: The objective of the 1st European AIDS Clinical Society meeting on Standard of Care in Europe was to raise awareness of the European scenario and come to an agreement on actions that could be taken in the future. METHODS: Data-driven presentations were given on specific topics followed...... by interactive panel discussions. RESULTS: In Eastern European countries, the epidemic is largely driven by injecting drug use, in contrast with Western Europe where the infection mainly occurs through heterosexual contact. A high proportion of people living with HIV remain unaware of their infection...... diagnosed multi-drug-resistant cases. Hepatitis C is widespread in selected geographical areas and risk groups. CONCLUSIONS: The key conclusion from the meeting was that a high-priority group of actions could be identified, including: increasing HIV awareness and testing, improving training for health care...

  10. 78 FR 37452 - Standard Instrument Approach Procedures, and Takeoff Minimums and Obstacle Departure Procedures...

    Science.gov (United States)

    2013-06-21

    ..., 2013. John M. Allen, Director, Flight Standards Service. Adoption of the Amendment Accordingly..., Amdt 1. 7/25/13 FL Tampa Tampa Executive. 3/0405 6/6/13 ILS OR LOC RWY 23, Amdt 1. 7/25/13 FL Milton...

  11. European Society of Anaesthesiology and European Board of Anaesthesiology guidelines for procedural sedation and analgesia in adults

    NARCIS (Netherlands)

    Hinkelbein, Jochen; Lamperti, Massimo; Akeson, Jonas; Santos, Joao; Costa, Joao; De Robertis, Edoardo; Longrois, Dan; Novak-Jankovic, Vesna; Petrini, Flavia; Struys, Michel M. R. F.; Veyckemans, Francis; Fuchs-Buder, Thomas; Fitzgerald, Robert

    2018-01-01

    Procedural sedation and analgesia (PSA) has become a widespread practice given the increasing demand to relieve anxiety, discomfort and pain during invasive diagnostic and therapeutic procedures. The role of, and credentialing required by, anaesthesiologists and practitioners performing PSA has been

  12. The Effectiveness of International Financial Reporting Standard on the European Union

    Directory of Open Access Journals (Sweden)

    Sarhad Hamza Khdir

    2017-01-01

    Full Text Available The objective of mandatory adoption of IFRS is to enhance the quality of accounting information in worldwide. However, this effort made challenged for European Union as a supranational body to achieve similar advantages of converged the IFRS standards. This study examines the effectiveness of IFRS on the European Union as a supranational body and whether the EU has successfully converged to the IFRS standards. The paper will also analyze if there are any difficulties with switching to the IFRS standards versus the traditional local accounting practices in EU. The results obtained show that the first application of IFRS has adopted among EU countries and the results indicate that the adoption of IFRS leads to improvement in value relevance. The results also imply that the IFRS adoption for EU does not ensure better quality of accounting information and standardized IFRS is not effective to implement for all EU because there is a lot of misperception in terms of these guidelines for preparing financial statement. The culture difference among EU shows that IFRS is not fits size standard for all EU that can lead EU to conform at the same time. The conclusion of this report will provide the answer whether it is or not effective for the EU to fully converge to the IFRS standards as a whole.

  13. The philosophy and limitations of FAA aeromedical standards, policies and procedures.

    Science.gov (United States)

    1971-06-01

    Designated Aviation Medical Examiners need available basic information concerning the FAA medical certification system, the philosophy which underlies standards, policy and procedures, and certain limitations of the system. It is through such informa...

  14. Trends and the determination of effective doses for standard X-ray procedures

    International Nuclear Information System (INIS)

    Johnson, H.M.; Neduzak, C.; Gallet, J.; Sandeman, J.

    2001-01-01

    Trends in the entrance skin exposures (air kerma) for standard x-ray imaging procedures are reported for the Province of Manitoba, Canada. Average annual data per procedure using standard phantoms and standard ion chambers have been recorded since 1981. For example, chest air kerma (backscatter included) has decreased from 0.14 to 0.09 mGy. Confounding factors may negate the gains unless facility quality control programs are maintained. The data were obtained for a quality assurance and regulatory compliance program. Quoting such data for risk evaluation purposes lacks rigor hence a compartment model for organ apportioning, using organ absorbed doses and weighting factors, has been applied to determine effective dose per procedure. The effective doses for the standard procedures are presented, including the value of 0.027 mSv (1999) calculated for the effective dose in PA chest imaging. (author)

  15. Development of a standard operating procedure for analysis of ammonia concentrations in coal fly ash.

    Science.gov (United States)

    2015-04-01

    Research was performed to support the development and recommendation of a standard operating : procedure (SOP) for analyzing the ammonia content in fly ash intended for use in concrete. A review : of existing ash producers found that several differen...

  16. Licensing procedure, nuclear codes and standards in the Federal Republic of Germany

    International Nuclear Information System (INIS)

    Schultheiss, G.F.

    1980-01-01

    The present paper deals with legal background of licensing in nuclear technology and atomic energy use, licensing procedures for nuclear power plants and with codes, standards and guidelines in the Federal Republic of Germany. (orig./RW)

  17. Perspectives and Problems of Harmonizing Energy Legislation of Ukraine with the European Union Standards

    Directory of Open Access Journals (Sweden)

    Volodymyrivna Komelina Olha

    2017-12-01

    Full Text Available Essence, features and components of the energy market was investigated in the article. Regulatory support of energy efficiency and energy saving in the European Union and Ukraine was analyzed. Ukraine obligations due to the harmonization of the energy legislation with the EU standards were defined. Problems in the housing and communal services (HCS as one of the largest consumers of energy resources were revealed.

  18. 9 CFR 354.210 - Minimum standards for sanitation, facilities, and operating procedures in official plants.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 2 2010-01-01 2010-01-01 false Minimum standards for sanitation, facilities, and operating procedures in official plants. 354.210 Section 354.210 Animals and Animal Products... sanitation, facilities, and operating procedures in official plants. The provisions of §§ 354.210 to 354.247...

  19. 40 CFR 75.38 - Standard missing data procedures for Hg CEMS.

    Science.gov (United States)

    2010-07-01

    ... Hg CEMS. 75.38 Section 75.38 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED... Standard missing data procedures for Hg CEMS. (a) Once 720 quality assured monitor operating hours of Hg... substitute data for Hg concentration in accordance with the procedures in ( 75.33(b)(1) through (b)(4...

  20. Standard testing procedures for optical fiber and unshielded twisted pair at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Adams, R.L.

    1993-11-01

    This document will establish a working standard for testing optical fiber and unshielded twisted pair cables included in the Lab-wide telecommunications cabling system. The purpose of these standard testing procedures is to deliver to all Sandians a reliable, low-maintenance, state-of-the-art, ubiquitous telecommunications cabling infrastructure capable of satisfying all current and future telecommunication needs.

  1. EVALUASI SANITATION STANDARD OPERATING PROCEDURES KERUPUKAMPLANG DI UD SARINA KECAMATAN KALIANGET KABUPATEN SUMENEP

    Directory of Open Access Journals (Sweden)

    Ach Triharjono

    2016-11-01

    Full Text Available Industri pangan untuk menghasilkan produk yang memenuhi standar keamanan pangan. Standar tersebut dapat dipenuhi dengan menerapkan 8 aspek kunci Sanitation Standard Operating Prosedures (SSOP. Tujuan dari penelitian ini adalah untuk memperoleh hasil penerapan 8 aspek kunci Sanitation Standard Operating Procedures (SSOP dan mengevaluasi penerapan Sanitation Standard Operating Procedures (SSOP Di UD Sarina Kecamatan Kalianget Kabupaten Sumenep. Jenis penelitian ini bersifat deskriptif dengan lokasi penelitian di UD Sarina Kecamatan Kalianget Kabupaten Sumenep. Hasil penelitian diketahui bahwa penerapan 8 aspek kunci Sanitation Standard Operating Procedures (SSOP di UD Sarina sudah terlaksana tapi terdapat 3 tahapan kunci yang belum terlaksana dengan baik yaitu pencegahan kontaminasi silang, pengawasan kondisi kesehatan personil dan menghilangkan hama dari unit pengolahan. Hal yang perlu ditingkatkan terkait dengan penerapan SSOP di UD Sarina yaitu masih perlu adanya manual prosedur untuk berbagai pelaksanaan sanitasi yang dilakukan oleh UD Sarina ini

  2. Objectives, standards and criteria for radioactive waste disposal in the European Community

    International Nuclear Information System (INIS)

    Orlowski, S.; Schaller, K.H.

    1989-01-01

    The present report, edited by a working group within the framework of the European Commission research programme on radioactive waste management and disposal, reviews the objectives, standards and criteria for radioactive waste disposal in the European Community with a view to identifying common features and differences in the regulatory frameworks of its Member States. Suggestions for possible harmonization are made. A few common general principles form the basis for legal and regulatory measures. These principles apply to and are discussed for the following: radiation protection (with the systems of dose limitation and control), ethical and sociological questions, environmental and natural resources protection, and nuclear safeguards. A description is given of the implementation of common principles, standards and requirements at Community level, in line with requirements laid down in the European Community Treaties, and in international conventions and recommendations. This is followed by a review of the implementation of basic criteria by national safety authorities. Regulatory measures and national policies, and the approaches used in devising criteria are discussed for both near-surface disposal of low-level waste, and for deep geological disposal of waste in continental geological formations. Finally, the roles and duties of the operators of radioactive waste facilities are reported. More detailed information on particular aspects is presented in the annexes

  3. The Impact of European Union’s Newly-Adopted Environmental Standards on its Trading Partners

    Directory of Open Access Journals (Sweden)

    Burnete Sorin

    2015-12-01

    Full Text Available The adoption by the European Union of environmental and social standards seems to affect trade relations with countries from outside the Union. Most seriously hurt are a great number of developing countries that are highly dependent on the European market for their exports. Complying with the said regulations means higher production costs, which eat into the respective countries’ international competitiveness. However, for all the widespread discontent, many developing countries are taking steps in order to adjust their production and export systems to the new rules. Unfortunately it will probably take a long time until full compliance is achieved. Meanwhile, in the short run, the frequent clashes between developing countries and their partners in the West in respect of environmental and social issues are disrupting the smooth functioning of international trade.

  4. THE CONFORMITY OF MACHINE TOOLS WITH RESPECT TO EUROPEAN SAFETY STANDARDS

    CERN Multimedia

    TIS/TE

    2000-01-01

    European regulations require that all motorized machine tools conform to the latest safety standards by the end of the year 2000. CERN must follow these regulations and has already modified most of its machine tools accordingly. However, there is still a small number of machine tools which have not yet been modified as required. These machines should not be used until they are brought up to the required safety standards, failing which the machines should be discarded. One can recognise which machine tools conform with the latest standards by the indication 'CS' on the identification plate of the machine, see foto below. In cases of doubt about the status of a machine tool you should contact K. Altherr/EST or C. Margaroli/TIS for advice.

  5. THE CONFORMITY OF MACHINE TOOLS WITH RESPECT TO EUROPEAN SAFETY STANDARDS

    CERN Multimedia

    TIS/TE

    2001-01-01

    European regulations require that all motorized machine tools conform to the latest safety standards by the end of the year 2000. CERN must follow these regulations and has already modified most of its machine tools accordingly. However, there is still a small number of machine tools which have not yet been modified as required. These machines should not be used until they are brought up to the required safety standards, failing which the machines should be discarded. One can recognise which machine tools conform with the latest standards by the indication 'CS' on the identification plate of the machine, see foto below. In cases of doubt about the status of a machine tool you should contact K. Altherr/EST or C. Margaroli/TIS for advice.

  6. Towards the European Union’s Education Standards: Expectations of the Ukrainians

    Directory of Open Access Journals (Sweden)

    Mykhaylo Bagmet

    2017-06-01

    Full Text Available The paper is devoted to the analysis of study results concerning the attitude of the population of Southern Ukraine to the European Union and willingness to implement the European education standards at higher education institution. The analysis of earlier studies revealed that most of the population accepts the necessity of joining the EU, its values and educational standards. But the Southern Ukraine’s population has some features that distinguish it from other regions so the hypothesis was that the results would significantly differ from national polls. Using questionnaire poll and expert assessment methods to verify the hypothesis we obtained the results that showed that in the South of Ukraine a smaller share of population were less favorable to the joining the EU. The public opinion poll about the education standards, implementation of Bologna process in Ukraine and the main obstacles of it demonstrated that students and faculty were willing to implement Bologna principles but financial limitations, corruption, lack of information were still the determinants of a weak progress in this area.

  7. The standardized computerized 24-h dietary recall method EPIC-Soft adapted for pan-European dietary monitoring

    DEFF Research Database (Denmark)

    Slimani, N.; Casagrande, C.; Nicolas, G.

    2011-01-01

    Background/Objectives: The EPIC-Soft program (the software initially developed to conduct 24-h dietary recalls (24-HDRs) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study) was recommended as the best way to standardize 24-HDRs for future pan-European dietary monitor...

  8. Transparency of standard terms under the Unfair Contract Terms Directive and the Proposal for a Common European Sales Law

    OpenAIRE

    Loos, M.B.M.

    2015-01-01

    This paper discusses whether and to what extent the transparency principle is applicable to standard contract terms legislation under European Union law and what the consequences are when the principle, in so far as it is recognized, is breached. To that extent, it focuses first on the Unfair Contract Terms Directive and second on the proposal for a Common European Sales Law.

  9. Deconstructing Institutionalisation of the European Standards for Quality Assurance: From Instrument Mixes to Quality Cultures and Implications for International Research

    Science.gov (United States)

    Kohoutek, Jan

    2016-01-01

    The paper enquires into the implementation of the European Standards and Guidelines for Internal Quality Assurance of Higher Education Institutions (ESG 1). The enquiry uses data from universities in the Czech Republic and compares them against those obtained in the relevant pan-European survey. The aims are to empirically deconstruct ESG 1…

  10. Match between classroom dimensions and students' anthropometry: re-equipment according to European educational furniture standard.

    Science.gov (United States)

    Macedo, Angela C; Morais, André V; Martins, Henriqueta F; Martins, João C; Pais, Silvina M; Mayan, Olga S

    2015-02-01

    The aim of this study was to investigate mismatch between students and classroom furniture dimensions and evaluate the improvement in implementing the European furniture standard. In Portugal, school furniture does not meet any national ergonomic criteria, so it cannot fit students' anthropometric measures. A total of 893 students belonging to third (7th through 9th grades) and secondary (10th through 12th grades) cycles participated in the study. Anthropometric measurements of the students were gathered in several physical education classes. The furniture dimensions were measured for two models of tables and seats. Several two-way equations for match criteria based on published studies were applied to data. The percentage of students who match with classroom furniture dimensions is low (24% and 44% between table and students, 4% and 9% between seat and students at 7th and 12th grades, respectively). Table is high for the third cycle, seat is high for both cycles, and seat depth fits well to students. No significant relationship was found between ergonomic mismatch and prevalence of pain. For each cycle, at least two different sizes indicated in the European standard should be available to students, considering the large variability in body dimensions within each cycle. The match criteria used gives a large percentage of students without pain in a mismatch situation. Future measures applying to secondary schools should revise the decision of selecting a single size of classroom furniture and improve the implementation of the European standard. New criteria for ergonomic mismatch are needed that more closely model the responses about discomfort/pain.

  11. Improving the review of standard operating procedures: a novel electronic system for compounding pharmacies.

    Science.gov (United States)

    Brensel, Robert; Brensel, Scott; Ng, Amy

    2013-01-01

    Since the New England Compounding Center disaster in 2012, the importance of following correct procedures during every phase of customized pharmacy has been a focus of governmental interest and action as well as public scrutiny. Many pharmacies rely on the rote review of standard operating procedures to ensure that staff members understand and follow protocols that ensure the safety and potency of all compounds prepared, but that approach to continuing education can be cumbersome and needlessly time-consuming. In addition, documenting and retrieving evidence of employee competence can be difficult. In this article, we describe our use of online technology to improve our methods of educating staff about the full range of standard operating procedures that must be followed in our pharmacy. The system we devised and implemented has proven to be effective, easy to update and maintain, very inexpensive, and user friendly. Its use has reduced the time previously required for a read-over review of standard operating procedures from 30 or 40 minutes to 5 or 10 minutes in weekly staff meetings, and we can now easily document and access proof of employees' comprehension of that content. It is our hope that other small compounding pharmacies will also find this system of online standard operating procedure review helpful.

  12. Distribution of stress in greenhouses frames estimated by aerodynamic coefficients of Brazilian and European standards

    Directory of Open Access Journals (Sweden)

    José Gabriel Vieira Neto

    2016-04-01

    Full Text Available ABSTRACT Widely disseminated in both national and international scenarios, greenhouses are agribusiness solutions which are designed to allow for greater efficiency and control of the cultivation of plants. Bearing this in mind, the construction of greenhouses should take into consideration the incidence of wind, and other such aspects of comfort and safety, and ensure they are factored into the design of structural elements. In this study, we evaluated the effects of pressure coefficients established by the European standard EN 13031-1 (2001 and the Brazilian standard ABNT (1988, which are applicable to the structures of greenhouses with flat roofs, taking into account the following variables: roof slope, external and internal pressure coefficients and height-span ratio of the structure. Using the ANSYSTM computer program, zones of columns and roof were discretized by the Beam44 finite element to identify the maximum and minimum stress portions connected to the aerodynamic coefficients. With this analysis, we found that, in the smallest roof slope (a equal to 20°, the frame stress was quite similar for standards adopted. On the other hand, for the greatest inclination (a equal to 26°, the stress was consistently lower under the Brazilian standard. In view of this, we came to the conclusion that the differences between stresses when applying both standards were more significant at the higher degrees of height-span ratio and roof slope.

  13. Harmonization of welding qualification provisions in RCC-M and European standards

    International Nuclear Information System (INIS)

    Lemoine, M.; Lainez, B.; Anastassiades, P.

    2007-01-01

    Since a long time, numerous precautions for welding have been integrated in the nuclear codes, in particular in the RCC-M applicable to pressurized water reactors, in order to guarantee a high quality level of permanent assemblies. In parallel, European and ISO standardization works have led to a harmonisation of practices on qualification of welding processes, welders and operators. In the context of the regulatory evolutions presented during this conference, it was judged appropriate to bring closer the RCC-M practices and those of EN and ISO standards, while taking the precaution of specifying, if necessary, the complementary provisions allowing maintaining guarantees of quality consistent with the prior experience feedback. This paper presents the amendments brought to the RCC-M Code by the 2005 and 2007 addenda, in order to respond to this objective, and develops their motivations. (authors) [fr

  14. The primary exposure standard for Co-60 gamma radiation: characteristics and measurements procedures

    International Nuclear Information System (INIS)

    Laitano, R.F.; Toni, M.P.

    1983-01-01

    A description is given of a cavity ionization chamber used, as a primary exposure standard, at the Laboratorio di Metrologia delle Radiazioni Ionizzanti of the ENEA in Italy. The primary standard is designed to make absolute measurements of exposure due to the Co-60 gamma radiation. The procedures for the realizationof the exposure unit are also described. Finally results of some international comparisons are reported

  15. 2017 update of the European Federation for Colposcopy (EFC) performance standards for the practice of colposcopy.

    Science.gov (United States)

    Petry, K Ulrich; Nieminen, Pekka J; Leeson, Simon C; Bergeron, Christine O M A; Redman, Charles W E

    2018-03-16

    A refinement of quality indicators (QIs) is described whereby the quality of care can be measured across colposcopy services in different countries and healthcare settings. A five-round Delphi process was conducted at successive satellite meetings from 2011 to 2015 of leading European colposcopists to refine the most high-scoring QIs relevant to colposcopic practice. A review and refinement of the wording of the standards and their criteria was undertaken by national society representatives. Six quality indicators were identified and refined. "Documentation of whether the squamocolumnar junction (SCJ) has been visible or not" was changed into "for cervical colposcopy transformation zone (TZ) type (1, 2 or 3) should be documented". The standard "percentage of cases having a colposcopic examination prior to treatment for abnormal cytology" was changed to "percentage of cases having a colposcopic examination prior to treatment for abnormal cervical screening test". The standard "percentage of all excisional treatments/conizations containing CIN2+ (cervical intra-epithelial neoplasia grade two or worse)" was changed into "percentage of excisional treatments/conizations having a definitive histology of CIN2+. Definitive histology is highest grade from any diagnostic or therapeutic biopsies". The standard "percentage of excised lesions/conizations with clear margins" was unchanged. The remaining two QIs define the minimum caseloads required for colposcopists. However, "cytology" was replaced by "screening results" to acknowledge the introduction of human papillomavirus testing to European screening programmes. Six QIs were identified to define good practice in colposcopy. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  16. Standard comparison of local mental health care systems in eight European countries.

    Science.gov (United States)

    Gutiérrez-Colosía, M R; Salvador-Carulla, L; Salinas-Pérez, J A; García-Alonso, C R; Cid, J; Salazzari, D; Montagni, I; Tedeschi, F; Cetrano, G; Chevreul, K; Kalseth, J; Hagmair, G; Straßmayr, C; Park, A L; Sfectu, R; Ala-Nikkola, T; González-Caballero, J L; Rabbi, L; Kalseth, B; Amaddeo, F

    2017-09-18

    There is a need of more quantitative standardised data to compare local Mental Health Systems (MHSs) across international jurisdictions. Problems related to terminological variability and commensurability in the evaluation of services hamper like-with-like comparisons and hinder the development of work in this area. This study was aimed to provide standard assessment and comparison of MHS in selected local areas in Europe, contributing to a better understanding of MHS and related allocation of resources at local level and to lessen the scarcity in standard service comparison in Europe. This study is part of the Seventh Framework programme REFINEMENT (Research on Financing Systems' Effect on the Quality of Mental Health Care in Europe) project. A total of eight study areas from European countries with different systems of care (Austria, England, Finland, France, Italy, Norway, Romania, Spain) were analysed using a standard open-access classification system (Description and Evaluation of Services for Long Term Care in Europe, DESDE-LTC). All publicly funded services universally accessible to adults (≥18 years) with a psychiatric disorder were coded. Care availability, diversity and capacity were compared across these eight local MHS. The comparison of MHS revealed more community-oriented delivery systems in the areas of England (Hampshire) and Southern European countries (Verona - Italy and Girona - Spain). Community-oriented systems with a higher proportion of hospital care were identified in Austria (Industrieviertel) and Scandinavian countries (Sør-Trøndelag in Norway and Helsinki-Uusimaa in Finland), while Loiret (France) was considered as a predominantly hospital-based system. The MHS in Suceava (Romania) was still in transition to community care. There is a significant variation in care availability and capacity across MHS of local areas in Europe. This information is relevant for understanding the process of implementation of community-oriented mental

  17. APPLICATION OF EUROPEAN STANDARDS OF FINANCIAL STATEMENTS – INFORMATIONAL RESOURSE OF CONSUMER COOPERATION DEVELOPMENT IN UKRAINE

    Directory of Open Access Journals (Sweden)

    Stepan KOSHKAROV

    2016-07-01

    Full Text Available More than 120 countries use the International Financial Reporting Standards (IFRS and the International Accounting Standards (IAS. The Association Agreement between Ukraine and the EU obliges Ukraine to consider European convergence of accounting and reporting. Since 2012 for some entities the use of IFRS has been compulsory, but for others – voluntary. This trend coincides with the imperative necessity of the consumer cooperation of Ukraine to reform its multilevel informational system as a key component of its effective management and successful implementation of controlling. It is proposed to start reforming with the introduction of IFRS and IAS. Consumer cooperation represents cooperative sector of Ukrainian economy and is included into different international and European cooperative associations. With its historic mission to meet the needs of its members, socio-economic and cultural development of rural areas, in terms of the crisis it faces the serious problem of the systemic reforming under existing conditions through the innovative development and use of experience of economically developed countries, especially the EU.

  18. The Regina Elena National Cancer Institute process of accreditation according to the standards of the Organisation of European Cancer Institutes.

    Science.gov (United States)

    Canitano, Stefano; Di Turi, Annunziata; Caolo, Giuseppina; Pignatelli, Adriana C; Papa, Elena; Branca, Marta; Cerimele, Marina; De Maria, Ruggero

    2015-01-01

    The accreditation process is, on the one hand, a tool used to homogenize procedures, rendering comparable and standardized processes of care, and on the other, a methodology employed to develop a culture of quality improvement. Although not yet proven by evidence-based studies that health outcomes improve as a result of an accreditation to excellence, it is undeniable that better control of healthcare processes results in better quality and safety of diagnostic and therapeutic pathways. The Regina Elena National Cancer Institute underwent the accreditation process in accordance with the standards criteria set by the Organisation of European Cancer Institutes (OECI), and it has recently completed the process, acquiring its designation as a Comprehensive Cancer Center (CCC). This was an invaluable opportunity for the Regina Elena Institute to create a more cohesive environment, to widely establish a culture of quality, to implement an institutional information system, and to accelerate the process of patient involvement in strategic decisions. The steps of the process allowed us to evaluate the performance and the organization of the institute and put amendments in place designed to be adopted through 26 improvement actions. These actions regarded several aspects of the institute, including quality culture, information communication technology system, care, clinical trials unit, disease management team, nursing, and patient empowerment and involvement. Each area has a timeline. We chose to present the following 3 improvement actions: clinical trial center, computerized ambulatory medical record, and centrality of patient and humanization of clinical pathway.

  19. Standard operating procedures for female orgasmic disorder: consensus of the International Society for Sexual Medicine

    NARCIS (Netherlands)

    Laan, Ellen; Rellini, Alessandra H.; Barnes, Tricia

    2013-01-01

    As the field of sexual medicine evolves, it is important to continually improve patient care by developing contemporary "standard operating procedures" (SOPs), reflecting the consensus view of experts in sexual medicine. Few, if any, consensus SOPs have been developed for the diagnosis and treatment

  20. Procedure-related mortality of endovascular abdominal aortic aneurysm repair using revised reporting standards.

    NARCIS (Netherlands)

    Konig, G.G.; Vallabhneni, S.R.; Marrewijk, C.J. van; Leurs, L.J.; Laheij, R.J.F.; Buth, J.

    2007-01-01

    OBJECTIVE: The aim of this study was to evaluate the definition of Procedure-related mortality after endovascular aneurysm repair (EVAR) as defined by the Committee for Standardized Reporting Practices in Vascular Surgery. METHODS: Data on patients with an AAA were taken from the EUROSTAR database.

  1. Evolution of standardized procedures for adjusting lumber properties for change in moisture content

    Science.gov (United States)

    David W. Green; James W. Evans

    2001-01-01

    This paper documents the development of procedures in American Society for Testing and Materials standards for adjusting the allowable properties of lumber for changes in moisture content. The paper discusses the historical context of efforts to establish allowable properties on a consensus basis, beginning in the 19th century. Where possible, the reasons for proposed...

  2. Procedures and Standards for Residential Ventilation System Commissioning: An Annotated Bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Stratton, J. Chris [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Wray, Craig P. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2013-04-01

    Beginning with the 2008 version of Title 24, new homes in California must comply with ANSI/ASHRAE Standard 62.2-2007 requirements for residential ventilation. Where installed, the limited data available indicate that mechanical ventilation systems do not always perform optimally or even as many codes and forecasts predict. Commissioning such systems when they are installed or during subsequent building retrofits is a step towards eliminating deficiencies and optimizing the tradeoff between energy use and acceptable IAQ. Work funded by the California Energy Commission about a decade ago at Berkeley Lab documented procedures for residential commissioning, but did not focus on ventilation systems. Since then, standards and approaches for commissioning ventilation systems have been an active area of work in Europe. This report describes our efforts to collect new literature on commissioning procedures and to identify information that can be used to support the future development of residential-ventilation-specific procedures and standards. We recommend that a standardized commissioning process and a commissioning guide for practitioners be developed, along with a combined energy and IAQ benefit assessment standard and tool, and a diagnostic guide for estimating continuous pollutant emission rates of concern in residences (including a database that lists emission test data for commercially-available labeled products).

  3. Standard operating procedures improve acute neurologic care in a sub-Saharan African setting.

    Science.gov (United States)

    Jaiteh, Lamin E S; Helwig, Stefan A; Jagne, Abubacarr; Ragoschke-Schumm, Andreas; Sarr, Catherine; Walter, Silke; Lesmeister, Martin; Manitz, Matthias; Blaß, Sebastian; Weis, Sarah; Schlund, Verena; Bah, Neneh; Kauffmann, Jil; Fousse, Mathias; Kangankan, Sabina; Ramos Cabrera, Asmell; Kronfeld, Kai; Ruckes, Christian; Liu, Yang; Nyan, Ousman; Fassbender, Klaus

    2017-07-11

    Quality of neurologic emergency management in an under-resourced country may be improved by standard operating procedures (SOPs). Neurologic SOPs were implemented in a large urban (Banjul) and a small rural (Brikama) hospital in the Gambia. As quality indicators of neurologic emergency management, performance of key procedures was assessed at baseline and in the first and second implementation years. At Banjul, 100 patients of the first-year intervention group exhibited higher rates of general procedures of emergency management than 105 control patients, such as neurologic examination (99.0% vs 91.4%; p process quality of neurologic emergency management in under-resourced settings. This study provides Class IV evidence that, for patients with suspected neurologic emergencies in sub-Saharan Africa, neurologic SOPs increase the rate of performance of guideline-recommended procedures. Copyright © 2017 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

  4. A Guide for Developing Standard Operating Job Procedures for the Pump Station Process Wastewater Treatment Facility. SOJP No. 3.

    Science.gov (United States)

    Perley, Gordon F.

    This is a guide for standard operating job procedures for the pump station process of wastewater treatment plants. Step-by-step instructions are given for pre-start up inspection, start-up procedures, continuous routine operation procedures, and shut-down procedures. A general description of the equipment used in the process is given. Two…

  5. PFGE standard operating procedures for Listeria monocytogenes: harmonizing the typing of food and clinical strains in Europe.

    Science.gov (United States)

    Michelon, Damien; Félix, Benjamin; Vingadassalon, Noemie; Mariet, Jean-François; Larsson, Jonas T; Møller-Nielsen, Eva; Roussel, Sophie

    2015-03-01

    Listeria monocytogenes is a foodborne pathogen responsible for a severe disease known as listeriosis. The European Centre for Disease Prevention and Control (ECDC) coordinates a network of national public health laboratories (NPHLs) in charge of typing clinical strains. In food, it is the European Union Reference Laboratory for L. monocytogenes (EURL Lm), which manages a network of National Reference Laboratories (NRLs). A pulsed-field gel electrophoresis (PFGE) standard operating procedure (EURL SOP) has been used routinely at the EURL Lm since 2007. The EURL Lm has recommended that NRLs use the EURL SOP, whereas the Statens Serum Institut (SSI), under contract for ECDC, requested that NPHLs use Halpins' SOP (HSOP) published in 2010 for the PulseNet USA network. An update of Halpins' SOP (uHSOP) was published in 2013. To facilitate the exchange of profiles among human and food European reference laboratories, it is crucial to ensure that the PFGE profiles obtained with these different SOPs are comparable. The aim here was to compare the EURL SOP with HSOP and uHSOP. The panel comprised 114 well-characterized SSI/EURL strains. All were characterized at the EURL using both the EURL SOP and uHSOP. Seventy of the 114 strains were also characterized at the SSI using HSOP. The EURL SOP and uHSOP produced indistinguishable combined (ApaI/AscI) profiles for the 114 strains tested. The EURL SOP and HSOP produced indistinguishable combined profiles for 69 of the 70 strains tested. One strain displayed for the AscI profile an additional low-intensity band at 184 kbp with HSOP. For this strain, SSI and EUR Lm had already observed the same profile from NPHLs and NRLs. However, this deviation is minor as it accounted for about 1% of all the 114 combined profiles. This study should facilitate the exchange of reproducible PFGE profiles among human and food reference laboratories.

  6. A Standardized Procedure for a Pre-evaluation of the IED Instance

    Science.gov (United States)

    Panepinto, Deborah; Ruffino, Barbara; Zanetti, Mariachiara; Genon, Giuseppe

    2016-04-01

    This study presents a procedure, called EICS (Enterprise IPPC Compatibility Study) aimed at evaluating, by means of the calculation of three indexes, the compliance of the processes performed in an industrial plant with the guidelines provided by BREFs (BAT References) Documents. In fact, according to European Directive 2010/75/EU (concerning the Integrated Pollution Prevention and Control and repealing European Directive 2008/01/EC), industrial plants must require authorizations to the competent authority stating the conformity of their activity, in order to obtain this conformity they are advised to Best Available Technologies (BAT). The aim of the BATs is to avoid or minimize the impact of an industrial activity on the environment through the prevention of the atmospheric emissions, wastewater discharge and energetic consumption, and the correct waste management thus improving the efficiency of the plant. The procedure shown in the present paper has been tested on several types of industrial plant (cement plants, secondary smelt foundries, paper-mill, and automotive industries as regards their paint lines). In this paper, the application of EICS method to a cement plant is presented: the obtained results highlight a good correlation between the index values and the real situation of the plant.

  7. Photocatalytic air purifiers for indoor air: European standard and pilot room experiments.

    Science.gov (United States)

    Costarramone, N; Cantau, C; Desauziers, V; Pécheyran, C; Pigot, T; Lacombe, S

    2017-05-01

    At the European level (CEN/TC386), some efforts are currently devoted to new standards for comparing the efficiency of commercial photocatalytic material/devices in various application fields. Concerning prototype or commercial indoor photocatalytic air purifiers designed for volatile organic compounds (VOC) abatement, the methodology is based on a laboratory airtight chamber. The photocatalytic function is demonstrated by the mineralization of a mixture of five VOCs. Experimental data were obtained for four selected commercial devices and three commercial materials: drop of VOC concentration, but also identification of secondary species (with special attention to formaldehyde), mineralization rates, and Clean Air Delivery Rate (CADR). With two efficient air purifiers, these laboratory experiments were compared to the results in two experimental rooms (35-40 m 3 ) where air pollution was introduced through wooden floor and furniture. The systems' ageing was also studied. The safety of the commercial products was also assessed by the determination of nanoparticle release. Standardized tests are useful to rank photocatalytic air purifiers and passive materials and to discard inefficient ones. A good correlation between the standard experiments and the experimental room experiments was found, even if in the latter case, the concentration of lower weight VOCs drops less quickly than that of heavier VOCs.

  8. Appearance of discontinuities in spectra transformed by the piecewise direct instrument standardization procedure.

    Science.gov (United States)

    Gemperline, P J; Cho, J; Aldridge, P K; Sekulic, S S

    1996-09-01

    Several years ago, we noted that spectra transformed by the piecewise direct standardization (PDS) method may contain discontinuities. Having noticed that the problem was a recurring one, we studied it and recently diagnosed its source. Our investigations suggest that this problem also occurs in applications of window factor analysis, evolving factor analysis, and any other procedure that uses piecewise principal component models. In this work, we report the source of the problem and illustrate it with one example. A procedure is presented for eliminating the problem that is effective in PDS pattern recognition applications. Further work is needed to develop modified algorithms suitable for calibration applications.

  9. Standardizing the classification of abortion incidents: the Procedural Abortion Incident Reporting and Surveillance (PAIRS) Framework.

    Science.gov (United States)

    Taylor, Diana; Upadhyay, Ushma D; Fjerstad, Mary; Battistelli, Molly F; Weitz, Tracy A; Paul, Maureen E

    2017-07-01

    To develop and validate standardized criteria for assessing abortion-related incidents (adverse events, morbidities, near misses) for first-trimester aspiration abortion procedures and to demonstrate the utility of a standardized framework [the Procedural Abortion Incident Reporting & Surveillance (PAIRS) Framework] for estimating serious abortion-related adverse events. As part of a California-based study of early aspiration abortion provision conducted between 2007 and 2013, we developed and validated a standardized framework for defining and monitoring first-trimester (≤14weeks) aspiration abortion morbidity and adverse events using multiple methods: a literature review, framework criteria testing with empirical data, repeated expert reviews and data-based revisions to the framework. The final framework distinguishes incidents resulting from procedural abortion care (adverse events) from morbidity related to pregnancy, the abortion process and other nonabortion related conditions. It further classifies incidents by diagnosis (confirmatory data, etiology, risk factors), management (treatment type and location), timing (immediate or delayed), seriousness (minor or major) and outcome. Empirical validation of the framework using data from 19,673 women receiving aspiration abortions revealed almost an equal proportion of total adverse events (n=205, 1.04%) and total abortion- or pregnancy-related morbidity (n=194, 0.99%). The majority of adverse events were due to retained products of conception (0.37%), failed attempted abortion (0.15%) and postabortion infection (0.17%). Serious or major adverse events were rare (n=11, 0.06%). Distinguishing morbidity diagnoses from adverse events using a standardized, empirically tested framework confirms the very low frequency of serious adverse events related to clinic-based abortion care. The PAIRS Framework provides a useful set of tools to systematically classify and monitor abortion-related incidents for first

  10. Standard guidelines of care: Performing procedures in patients on or recently administered with isotretinoin

    Directory of Open Access Journals (Sweden)

    Venkataram Mysore

    2017-01-01

    Full Text Available Background: Currently, the standard protocol regarding the performance of procedures on patients receiving or having recently received isotretinoin (13-cis-retinoic acid states that the procedures should not be performed. The recommendations in standard books and drug insert require discontinuation of isotretinoin for 6 months before performing cosmetic procedures, including waxing, dermabrasion, chemical peels, laser procedures, or incisional and excisional cold-steel surgery. These recommendations have been followed for over two decades despite little evidence for the stated increased risk of scarring. Objective: The Association of Cutaneous Surgeons (I constituted a task force to review the evidence and to recommend consensus guidelines regarding the safety of skin procedures, including resurfacing, energy-device treatments, and dermatosurgical procedures in patients with concurrent or recent isotretinoin administration. Materials and Methods: Data were extracted from the literature through a PubMed search using the keywords “isotretinoin,” “safety,” “scarring,” “keloids,” “hypertrophic scarring,” and “pigmentation.” The evidence was then labeled and circulated to all members of task force for review. Results: The task force is of the opinion that there is insufficient evidence to support the current protocol of avoiding and delaying treatments in the patient group under consideration and recommends that the current practice should be discontinued.The task force concludes that performing procedures such as laser hair removal, fractional lasers for aging and acne scarring, lasers for pigmented skin lesions, fractional radio-frequency microneedling, superficial and medium-depth peels, microdermabrasion, dermaroller, biopsies, radio-frequency ablation, and superficial excisions is safe in patients with concurrent or recent isotretinoin administration.

  11. Standard operating procedure changed pre-hospital critical care anaesthesiologists’ behaviour: a quality control study

    Science.gov (United States)

    2013-01-01

    Introduction The ability of standard operating procedures to improve pre-hospital critical care by changing pre-hospital physician behaviour is uncertain. We report data from a prospective quality control study of the effect on pre-hospital critical care anaesthesiologists’ behaviour of implementing a standard operating procedure for pre-hospital controlled ventilation. Materials and methods Anaesthesiologists from eight pre-hospital critical care teams in the Central Denmark Region prospectively registered pre-hospital advanced airway-management data according to the Utstein-style template. We collected pre-intervention data from February 1st 2011 to January 31st 2012, implemented the standard operating procedure on February 1st 2012 and collected post intervention data from February 1st 2012 until October 31st 2012. We included transported patients of all ages in need of controlled ventilation treated with pre-hospital endotracheal intubation or the insertion of a supraglottic airways device. The objective was to evaluate whether the development and implementation of a standard operating procedure for controlled ventilation during transport could change pre-hospital critical care anaesthesiologists’ behaviour and thereby increase the use of automated ventilators in these patients. Results The implementation of a standard operating procedure increased the overall prevalence of automated ventilator use in transported patients in need of controlled ventilation from 0.40 (0.34-0.47) to 0.74 (0.69-0.80) with a prevalence ratio of 1.85 (1.57-2.19) (p = 0.00). The prevalence of automated ventilator use in transported traumatic brain injury patients in need of controlled ventilation increased from 0.44 (0.26-0.62) to 0.85 (0.62-0.97) with a prevalence ratio of 1.94 (1.26-3.0) (p = 0.0039). The prevalence of automated ventilator use in patients transported after return of spontaneous circulation following pre-hospital cardiac arrest increased from 0.39 (0

  12. Standard Evaluation Procedures (SEPs) and Data Entry Spreadsheet Templates (DESTs) for Endocrine Disruptor Screening Program (EDSP) Tier 1 Assays

    Science.gov (United States)

    This page provides information and access to Standard Evaluation Procedures (SEPs) and Data Entry Spreadsheet Templates (DESTs) developed by EPA's Office of Chemical Safety and Pollution Prevention (OCSPP).

  13. Worldwide review of existing standards and procedures for monitoring and analysing dam deformations

    International Nuclear Information System (INIS)

    Chrzanowski, A.; Avella, S.; Frodge, S.L.

    1993-01-01

    A study was carried out of existing standards and procedures for dam monitoring worldwide. The survey covers worldwide distribution of large dams, dam failures and dam safety legislation, required accuracy and frequency of monitoring surveys, and geometrical analysis of dam deformations. Information is tabulated, on a per-country basis, of number of dam types, actual or preferred method of monitoring, dam safety legislation in place, standards and specifications for monitoring, whether automation of monitoring is included, whether geodetic systems have been designed, and sample specifications for monitoring concrete dams as recommended by the Swiss National Committee on Large Dams. 29 refs., 3 tabs

  14. Procedure and reference standard to determine the structural resolution in coordinate metrology

    Science.gov (United States)

    Illemann, Jens; Bartscher, Markus; Jusko, Otto; Härtig, Frank; Neuschaefer-Rube, Ulrich; Wendt, Klaus

    2014-06-01

    A new procedure and reference standards for specifying the structural resolution in coordinate metrology traceable to the SI unit the metre are proposed. With the definition of the structural resolution, a significant gap will be closed to complete ‘acceptance and verification tests’ of the coordinate measuring systems (CMSs) which are specified in the ISO 10360 series dealing with tactile sensors, optical sensors, and x-ray computed tomography measurement systems (CTs). The proposed new procedure uses reference standards with circular rounded edges. The idea is to measure the radius of curvature on a calibrated round edge structure. From the deviation between the measured and the calibrated radius, an analogue Gaussian broadening of the measurement system is determined. This value is a well-defined and easy-to-apply measure to define the structural resolution for dimensional measurements. It is applicable to CMSs which are based on different sensing principles, e.g. tactile, optical and CT systems. On the other hand, it has a physical meaning similar to the classical optical point-spread function. It makes it possible to predict which smallest details the CMS is capable of measuring reliably for an arbitrary object shape. The theoretical background of the new procedure is given, an appropriate reference standard is described and comparative, quantitative measurement data of CMSs featuring different sensors are shown.

  15. Reproductive health information and abortion services: standards developed by the European Court of Human Rights.

    Science.gov (United States)

    Westeson, Johanna

    2013-08-01

    In 3 recent judgments, the European Court of Human Rights addressed the issue of access to abortion and related reproductive health services. In 2 of the judgments, the Court declared that the state violated women's rights by obstructing access to legal health services, including abortion. In so doing, it referred to the state's failure to implement domestic norms on prenatal testing and conscientious objection, and recognized the relevance of international medical guidelines. This illustrates that domestic and international medical standards can serve as critical guidance to human rights courts. In the third case, the Court showed its unwillingness to declare access to abortion a human right per se, which is troubling from the perspective of women's right to health and dignity. The present article outlines the relevance of these cases for the reproductive health profession and argues that medical professional societies can influence human rights courts by developing and enforcing medical standards, not only for the benefit of abortion rights domestically but also for the advancement of women's human rights worldwide. Copyright © 2013 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

  16. Pragmatics of policy: the compliance of dutch environmental policy instruments to European union standards.

    Science.gov (United States)

    Kruitwagen, Sonja; Reudink, Melchert; Faber, Albert

    2009-04-01

    Despite a general decrease in Dutch environmental emission trends, it remains difficult to comply with European Union (EU) environmental policy targets. Furthermore, environmental issues have become increasingly complex and entangled with society. Therefore, Dutch environmental policy follows a pragmatic line by adopting a flexible approach for compliance, rather than aiming at further reduction at the source of emission. This may be politically useful in order to adequately reach EU targets, but restoration of environmental conditions may be delayed. However, due to the complexity of today's environmental issues, the restoration of environmental conditions might not be the only standard for a proper policy approach. Consequently this raises the question how the Dutch pragmatic approach to compliance qualifies in a broader policy assessment. In order to answer this question, we adapt a policy assessment framework, developed by Hemerijck and Hazeu (Bestuurskunde 13(2), 2004), based on the dimensions of legitimacy and policy logic. We apply this framework for three environmental policy assessments: flexible instruments in climate policy, fine-tuning of national and local measures to meet air quality standards, and derogation for the Nitrate Directive. We conclude with general assessment notes on the appliance of flexible instruments in environmental policy, showing that a broad and comprehensive perspective can help to understand the arguments to put such policy instruments into place and to identify trade-offs between assessment criteria.

  17. Validation of standard operating procedures in a multicenter retrospective study to identify -omics biomarkers for chronic low back pain.

    Directory of Open Access Journals (Sweden)

    Concetta Dagostino

    Full Text Available Chronic low back pain (CLBP is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine. Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories to obtain robust and reproducible results. To date, no validated standard operating procedures (SOPs for genetic/-omics studies in chronic pain have been developed. In this study, we validated an SOP model that will be used in the multicentre (5 centres retrospective "PainOmics" study, funded by the European Community in the 7th Framework Programme, which aims to develop new biomarkers for CLBP through three different -omics approaches: genomics, glycomics and activomics. The SOPs describe the specific procedures for (1 blood collection, (2 sample processing and storage, (3 shipping details and (4 cross-check testing and validation before assays that all the centres involved in the study have to follow. Multivariate analysis revealed the absolute specificity and homogeneity of the samples collected by the five centres for all genetics, glycomics and activomics analyses. The SOPs used in our multicenter study have been validated. Hence, they could represent an innovative tool for the correct management and collection of reliable samples in other large-omics-based multicenter studies.

  18. The fairness of national decision-making procedures : The views of adolescents in 18 european countries

    NARCIS (Netherlands)

    Ellenbroek, Moniek; Verkuijten, Maykel; Thijs, Jochem; Poppe, Edwin

    2014-01-01

    This study examines adolescents' evaluation of the fairness of three forms of democratic decision-making procedures (direct democracy, representative democracy and group representation) and one non-democratic procedure (oligarchy). Social dominance orientation-Egalitarianism (SDO-E), religious group

  19. Influence of the Thermal Inertia in the European Simplified Procedures for the Assessment of Buildings’ Energy Performance

    OpenAIRE

    Luca Evangelisti; Gabriele Battista; Claudia Guattari; Carmine Basilicata; Roberto de Lieto Vollaro

    2014-01-01

    This study aims to highlight the importance of thermal inertia in buildings. Nowadays, it is possible to use energy analysis software to simulate the building energy performance. Considering Italian standards, these analyses are based on the UNI TS 11300 that defines the procedures for the national implementation of the UNI EN ISO 13790. These standards require an energy analysis under steady-state condition, underestimating the thermal inertia of the building. In order to understand the iner...

  20. Comparative aspects of procedures to authorize the siting of electro-nuclear power stations among the member countrie of the European Community

    International Nuclear Information System (INIS)

    Montecchi, Gabriele.

    1981-10-01

    This paper makes a brief comparison of the licensing processes for nuclear installations in European Community States, in particular concerning consultation of the public, the competent authorities and the period for the procedure in the countries considered. (NEA) [fr

  1. Paving the way for a gold standard of care for infertility treatment: improving outcomes through standardization of laboratory procedures.

    Science.gov (United States)

    Schoolcraft, William; Meseguer, Marcos

    2017-10-01

    Infertility affects over 70 million couples globally. Access to, and interest in, assisted reproductive technologies is growing worldwide, with more couples seeking medical intervention to conceive, in particular by IVF. Despite numerous advances in IVF techniques since its first success in 1978, almost half of the patients treated remain childless. The multifactorial nature of IVF treatment means that success is dependent on many variables. Therefore, it is important to examine how each variable can be optimized to achieve the best possible outcomes for patients. The current approach to IVF is fragmented, with various protocols in use. A systematic approach to establishing optimum best practices may improve IVF success and live birth rates. Our vision of the future is that technological advancements in the laboratory setting are standardized and universally adopted to enable a gold standard of care. Implementation of best practices for laboratory procedures will enable clinicians to generate high-quality gametes, and to produce and identify gametes and embryos of maximum viability and implantation potential, which should contribute to improving take-home healthy baby rates. Copyright © 2017 The Authors. Published by Elsevier Ltd.. All rights reserved.

  2. 40 CFR 75.33 - Standard missing data procedures for SO2, NOX, Hg, and flow rate.

    Science.gov (United States)

    2010-07-01

    ... SO2, NOX, Hg, and flow rate. 75.33 Section 75.33 Protection of Environment ENVIRONMENTAL PROTECTION... Procedures § 75.33 Standard missing data procedures for SO2, NOX, Hg, and flow rate. (a) Following initial...—Missing Data Procedure for SO2 CEMS, CO2 CEMS, Moisture CEMS, Hg CEMS, and Diluent (CO2 or O2) Monitors...

  3. Use of cement in concrete according to European standard EN 206-1

    Directory of Open Access Journals (Sweden)

    Christoph Müller

    2012-04-01

    Full Text Available The manufacture of cements with several main constituents (blended cements is of particular importance with regard to reducing climatically relevant CO2 emissions in the cement industry. A wide variety of common cement products exists in the different EU Member States. They match local manufacturing conditions, throughout meeting particular climatic or other local conditions, including building practices. In general, all cements conforming to European Cement Standard EN 197-1 are suitable for the manufacture of concrete according to European Concrete Standard EN 206-1. Depending on the area of application, however, differences related to the cement type may possibly have to be taken into account to ensure the durability of the concretes manufactured with these cements. These regulations were laid down in National Application Documents (NADs to EN 206-1 dependent upon the exposure classes that a structural element is assigned to. This paper deals with the overall concept of EN 206-1 with regard to concrete durability. It gives an overview of the cement types used in Europe and the areas of application of cements conforming to EN 197-1 in concrete conforming to EN 206-1 and various national annexes. The option of combining several main constituents makes blended cements particularly well suited for combining the advantages of individual main constituents, and thus for developing these cements into even more robust systems. This process requires an integrated assessment of all requirements to be met by cements during manufacture and application. From a technical perspective these include the strength formation potential as well as good workability of the concrete and, in particular, the durability of the concrete made from these cements. The effects that the main constituents have with regard to properties relevant to durability can be utilized in particular in cements made from a combination of limestone/blastfurnace slag or limestone/fly ash as

  4. Effective reduction of fluoroscopy duration by using an advanced electroanatomic-mapping system and a standardized procedural protocol for ablation of atrial fibrillation: 'the unleaded study'.

    Science.gov (United States)

    Knecht, Sven; Sticherling, Christian; Reichlin, Tobias; Pavlovic, Nikola; Mühl, Aline; Schaer, Beat; Osswald, Stefan; Kühne, Michael

    2015-11-01

    It is recommended to keep exposure to ionizing radiation as low as reasonably achievable. The aim of this study was to determine whether fluoroscopy-free mapping and ablation using a standardized procedural protocol is feasible in patients undergoing pulmonary vein isolation (PVI). Sixty consecutive patients were analysed: Thirty consecutive patients undergoing PVI using Carto3 were treated using a standardized procedural fluoroscopy protocol with X-ray being disabled after transseptal puncture (Group 1) and compared with a set of previous 30 consecutive patients undergoing PVI without a specific recommendation regarding the use of fluoroscopy (Group 2). The main outcome measures were the feasibility of fluoroscopy-free mapping and ablation, total fluoroscopy time, total dose area product (DAP), and procedure time. Sixty patients (age 60 ± 10 years, 73% male, ejection fraction 0.55 ± 0.09, left atrium 42 ± 8 mm) were included. In Group 1, total fluoroscopy time was 4.2 (2.6-5.6) min and mapping and ablation during PVI without using fluoroscopy was feasible in 29 of 30 patients (97%). In Group 2, total fluoroscopy time was 9.3 (6.4-13.9) min (P fluoroscopy after transseptal puncture using a standardized procedural protocol is feasible in almost all patients and is associated with markedly decreased total fluoroscopy duration and DAP. Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2015. For permissions please email: journals.permissions@oup.com.

  5. Standardization of specifications and inspection procedures for LEU plate-type research reactor fuels

    International Nuclear Information System (INIS)

    1988-06-01

    With the transition to high density uranium LEU fuel, fabrication costs of research reactor fuel elements have a tendency to increase because of two reasons. First, the amount of the powder of the uranium compound required increases by more than a factor of five. Second, fabrication requirements are in many cases nearer the fabrication limits. Therefore, it is important that measures be undertaken to eliminate or reduce unnecessary requirements in the specification or inspection procedures of research reactor fuel elements utilizing LEU. An additional stimulus for standardizing specifications and inspection procedures at this time is provided by the fact that most LEU conversions will occur within a short time span, and that nearly all of them will require preparation of new specifications and inspection procedures. In this sense, the LEU conversions offer an opportunity for improving the rationality and efficiency of the fuel fabrication and inspection processes. This report focuses on the standardization of specifications and inspection processes of high uranium density LEU fuels for research reactors. However, in many cases the results can also be extended directly to other research reactor fuels. 15 refs, 1 fig., 3 tabs

  6. Raising the quality of rheumatology management recommendations: lessons from the EULAR process 10 years after provision of standard operating procedures.

    Science.gov (United States)

    Colebatch-Bourn, Alexandra N; Conaghan, Philip G; Arden, Nigel K; Cooper, Cyrus; Dougados, Maxime; Edwards, Christopher J

    2015-08-01

    To increase understanding of how to raise the quality of rheumatology guidelines by reviewing European League Against Rheumatism (EULAR) management recommendations, using the Appraisal of Guidelines for Research and Evaluation (AGREE) II instrument, 10 years after publication of the EULAR standardized operating procedures (SOP) for the production of recommendations. It was hoped that this work could help inform improvements in guideline development by other societies and organizations. The SOP were published in 2004 to ensure the quality of EULAR-endorsed recommendations. We reviewed 27 published EULAR recommendations for management using the AGREE II tool. This provides a framework to assess the quality of guidelines across six broad domains using 23 specific questions. Overall the EULAR recommendations reviewed have been performed to a high standard. There are particular strengths in the methodology and presentation of the guidelines; however, the results indicate areas for development in future recommendations: in particular, stakeholder involvement and applicability of the recommendations. Improvements in quality were evident in recent years, with patient representation in 9 of 15 (60.0%) recommendations published 2010-14 compared with 4 of 12 (33.3%) published 2000-09. In the last 10 years the overall quality of recommendations was good, with standards improving over the decade following publication of the SOP. However, this review process has identified potential areas for improvement, especially in patient representation and provision of implementation tools. The lessons from this work can be applied to the development of rheumatology guidelines by other societies and organizations. © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  7. The gold standard and the European Monetary Union (EMU) : are the factors that contributed to the breakdown of the gold standard also present in the EMU?

    OpenAIRE

    Wergeland, Helene

    2012-01-01

    This thesis seeks to identify the most important factors that contributed to the breakdown of the gold standard in the 1930s, and to see if these factors are present in the European Monetary Union (EMU) today. This is done in order to find out if the same factors might create, or have created, similar instabilities and problems in the EMU as they imposed on the interwar gold standard. The factors regarded as important for the breakdown of the gold standard are (1) the central ...

  8. Several companies will not be able to earn amounts necessary to meet strictest European Union standards

    International Nuclear Information System (INIS)

    Zackova, K.; Sobinkovic, B.

    2003-01-01

    Costs of meeting environmental laws, regulations and directives applying to industrial companies are relatively high. Some companies are therefore concerned that they will not be in the position to accumulate sufficient funds to meet the requirements of newly introduced legislation reflecting the European Union (EU) environmental standards. And those plants that will not manage to comply with the new regulation by the set deadline, will face a threat of being closed down. In some cases the threat will be softened by transition periods agreed on in course of pre-entry negotiations on the chapter environment and through time schedules provided for in the newly introduced regulations. Danish consultant company Niras in co-operation with Institute of Slovak and World Economy at SAV (Slovak Academy of Science) calculated that the costs related to implementation EU environmental standards by 2035 would amount to 437 bn Slovak crowns (Sk) (10.57 billion Euro). Chief Negotiator of Slovakia's EU-entry, Jan Figel confirmed that from financial point of view the implementation of environmental standards was the most demanding requirement of all. Experts cannot predict yet what part of these costs will be covered by companies themselves. The highest amount should be spent on water protection - 185 billion Sk (4.47 billion Euro) until 2030. In the waste disposal industry the necessary investments during the same period are estimated to 130 billion Sk (3.14 billion Euro) and another 90 billion Sk (2.18 billion Euro) will have to be spent on big incineration facilities. The mentioned amount of 437 billion Sk (10.57 billion Euro) does not include any costs related to liquidation of old environmental burdens. But this problem will be partially solved through the new environmental arrangements. Several industrial companies are not allowed to build new waste dumps as long as they have not liquidated the old ones or at leas have addressed the matter of contaminated soil. There is no

  9. Assortment structure in poplar plantation Populus x euramerjcana I-214 based on European standard

    Directory of Open Access Journals (Sweden)

    Danilović Milorad

    2005-01-01

    Full Text Available Assortment structure in poplar plantation Populus x euramericana I-214 was obtained by European standard for round wood. Based on the data of theoretical cutting, the correlation between total volume of assortments and tree diameter at breast height was established. Model of the function representing the relation between total volume of assortments of superior quality and tree diameter is reciprocal. The relation between total volumes of normal-quality assortments can be represented by a logarithm model of the function, and the relation between total volume of assortments which cannot be classified into any quality class and tree diameter is best represented by a degree model. Knots up to the height of 6 m had a significant effect on the percentage of classes of superior quality. If the lower branches were pruned from standing trees up to the height of 6 m, the percentage of this class would increase averagely by 22.07%. This shows that pruning of lower branches is a very significant plantation tending measure and that it should be performed in time. Sweep also caused the decrease of percentage of superior assortments, but not to the expected degree, because the plantation is situated along the river Sava.

  10. Addendum to the procedure of KWU standard calculation for PWR fuel assembly with gadolinium

    International Nuclear Information System (INIS)

    Andrade, E.P. de

    1993-01-01

    The objective of this work is to solve a doubt appeared in the standard procedure of KWU/Siemens for fuel assembly (FA) with gadolinium. In this procedure, the σ's and form functions of such assembly are modified by his effective heterogeneity factor factor (f eff ), which is defined as the ratio between the heterogeneity factors (f het ) of FA's with and without poison. The doubt appeared at the time to calculated the f het of FA without poison: should one consider the pure FA or the FA with poison in which the concentration of gadolinium would be set to zero, but one should keep that of natural uranium? The best results were obtained considering the second hypothesis. (author)

  11. Refractory Metal Heat Pipe Life Test - Test Plan and Standard Operating Procedures

    Science.gov (United States)

    Martin, J. J.; Reid, R. S.

    2010-01-01

    Refractory metal heat pipes developed during this project shall be subjected to various operating conditions to evaluate life-limiting corrosion factors. To accomplish this objective, various parameters shall be investigated, including the effect of temperature and mass fluence on long-term corrosion rate. The test series will begin with a performance test of one module to evaluate its performance and to establish the temperature and power settings for the remaining modules. The performance test will be followed by round-the-clock testing of 16 heat pipes. All heat pipes shall be nondestructively inspected at 6-month intervals. At longer intervals, specific modules will be destructively evaluated. Both the nondestructive and destructive evaluations shall be coordinated with Los Alamos National Laboratory. During the processing, setup, and testing of the heat pipes, standard operating procedures shall be developed. Initial procedures are listed here and, as hardware is developed, will be updated, incorporating findings and lessons learned.

  12. Assessment of organ doses by standard X-ray procedures in the GDR

    International Nuclear Information System (INIS)

    Tautz, M.; Brandt, G.A.

    1986-01-01

    A modern method has been described to assess the radiation burden by X-ray procedures with consideration of the standards of our Society for Medical Radiology in the GDR. The underlying methodology is a Monte Carlo computer technique, which simulates stochastically the energy deposition of X-ray photons in a mathematically described heterogeneous anthropomorphic phantom by Rosenstein (US Department of Health, Education and Welfare). To apply the procedure specific values for the following parameters must be determined for each dose estimation: projection and view, X-ray field size and location entrance exposure at skin surface, beam quality, source-to-image receptor distance. The base data are obtained in terms of tissue-air ratio. Organ doses were calculated for chest, urography, skull, cervical spine, thoracic spine, lumbar spine, pelvis and lymphography. Concluding possibilities have been discussed for reduction of radiation burden. 9 refs., 6 figs., 9 tabs. (author)

  13. Historical Development of NATO Stanag 6001 Language Standards and Common European Framework (CEF) and the Comparison of Their Current Status

    Science.gov (United States)

    Solak, Ekrem

    2011-01-01

    The aim of the article is to shed light on the historical development of language studies in military and social context and to compare the current status of NATO Stanag (Standard Agreement) 6001 language scale with Common European Framework (CEF). Language studies in military context date back to World War II and the emergence of Army Specialized…

  14. Transparency of standard terms under the Unfair Contract Terms Directive and the Proposal for a Common European Sales Law

    NARCIS (Netherlands)

    Loos, M.B.M.

    2015-01-01

    This paper discusses whether and to what extent the transparency principle is applicable to standard contract terms legislation under European Union law and what the consequences are when the principle, in so far as it is recognized, is breached. To that extent, it focuses first on the Unfair

  15. Students as Stakeholders in the Policy Context of the European Standards and Guidelines for Quality Assurance in Higher Education Institutions

    NARCIS (Netherlands)

    Logermann, Frauke; Leisyte, Liudvika; Curaj, Adrian; Matei, Liviu; Pricopie, Remus; Salmi, Jamil; Scott, Peter

    2015-01-01

    The European Standard and Guidelines for Quality Assurance (ESG) of 2005 can be defined as one of the major Bologna documents aimed at furthering the role of students as stakeholders in internal quality assurance processes at higher education institutions (HEIs). Still little is known about

  16. Chinese consensus statement on standard procedure and perioperative management of bronchial thermoplasty.

    Science.gov (United States)

    Lin, Jiangtao; Nong, Ying; Yang, Dong; Li, Shiyue; Wang, Guangfa; Su, Nan; Zhong, Nanshan

    2017-12-01

    Bronchial thermoplasty (BT) is a non-pharmacologic therapy for severe asthma. The proper procedure and perioperative management are very important for the effectiveness and safety of BT. China Asthma Alliance assembled a group of experts in asthma and BT to review the literature, drew on their own experiences, discussed, and then finalized by consensus to establish this standard practice guideline. This practice guideline is designed to guide clinicians as to proper patients' selection, preoperative assessment, postoperative management and follow-up. This practice guideline also proposed "China Alair System Registry Study (NCT02206269)" as the real-world study to enhance clinical utility of BT.

  17. Federal standards and procedures for the National Watershed Boundary Dataset (WBD)

    Science.gov (United States)

    ,; ,; ,

    2013-01-01

    The Watershed Boundary Dataset (WBD) is a comprehensive aggregated collection of hydrologic unit data consistent with the national criteria for delineation and resolution. This document establishes Federal standards and procedures for creating the WBD as seamless and hierarchical hydrologic unit data, based on topographic and hydrologic features at a 1:24,000 scale in the United States, except for Alaska at 1:63,360 scale, and 1:25,000 scale in the Caribbean. The data within the WBD have been reviewed for certification through the 12-digit hydrologic unit for compliance with the criteria outlined in this document. Any edits to certified data will be reviewed against this standard prior to inclusion. Although not required as part of the framework WBD, the guidelines contain details for compiling and delineating the boundaries of two additional levels, the 14- and 16-digit hydrologic units, as well as the use of higher resolution base information to improve delineations. The guidelines presented herein are designed to enable local, regional, and national partners to delineate hydrologic units consistently and accurately. Such consistency improves watershed management through efficient sharing of information and resources and by ensuring that digital geographic data are usable with other related Geographic Information System (GIS) data.Terminology, definitions, and procedural information are provided to ensure uniformity in hydrologic unit boundaries, names, and numerical codes. Detailed standards and specifications for data are included. The document also includes discussion of objectives, communications required for revising the data resolution in the United States and the Caribbean, as well as final review and data-quality criteria. Instances of unusual landforms or artificial features that affect the hydrologic units are described with metadata standards. Up-to-date information and availability of the hydrologic units are listed at http:// www

  18. Thyroid volume and urinary iodine in European schoolchildren: standardization of values for assessment of iodine deficiency

    NARCIS (Netherlands)

    Delange, F.; Benker, G.; Caron, P.; Eber, O.; Ott, W.; Peter, F.; Podoba, J.; Simescu, M.; Szybinsky, Z.; Vertongen, F.; Vitti, P.; Wiersinga, W.; Zamrazil, V.

    1997-01-01

    Up to 1992, most European countries used to be moderately to severely iodine deficient. The present study aimed at evaluating possible changes in the status of iodine nutrition in 12 European countries during the past few years. Thyroid volume was measured by ultrasonography in 7599 schoolchildren

  19. The regulatory framework of accounting and accounting standard-setting bodies in the European Union member states

    Directory of Open Access Journals (Sweden)

    Ivana Mamić-Sačer

    2015-12-01

    Full Text Available One of the principal features of accounting in the 21st century is harmonisation and stanardisation. Regulation of the European Parliament and European Council No. 1606/2002 harmonizes financial reporting for certain companies in the EU. However, national accounting principles are of great importance for financial reporting. The main purpose of this research was to investigate the application of generally accepted accounting principles, the regulatory accounting framework and the standard-setting bodies of EU member states. The analysis of these accounting issues was conducted with respect to all 28 EU member states. The results indicate that EU member states regulate their principal accounting issues through separate accounting acts or implement those issues in companies acts. Some EU member states do not have national accounting standards, the national accounting principles being incorporated in companies acts and accounting acts. Nevertheless, national accounting standard-setting bodies are governmental organisations in almost half the member states.

  20. Improving International Standards in Surgical and Procedural Training through Comparative Operative Log Growth Charts

    Directory of Open Access Journals (Sweden)

    Vannipa Vathanophas, M.D.

    2018-03-01

    Full Text Available Objective: To use these growth charts to critically assess sufficiency of cases and parity of cases between residents, and to compare these growth charts to available international standards for minimum case numbers. Methods: Operative Log Growth Charts were developed for key indicator procedures for graduating otolaryngology residents in 2012-2014 at a large teaching hospital in the capital city of a newly industrialized country. Comparisons were made between years of training and required minimum case numbers published by the ACGME RRC for Otolaryngology. Results: Data was available to create 7 key indicator operative log growth charts to include all available data from 2012-2014 residents. These growth charts were used to assess growth in operative procedures for residents in the program compared to historical norms in the program. Graduating residents surpassed ACGME minimum case numbers in Bronchoscopy only and were below the minimum numbers for the other key indicators tested. Conclusion: There is significant heterogeneity in the standards for otolaryngology training between countries. It is possible to develop program-specific and country-specific operative log growth charts.

  1. The Cox-maze IV procedure in its second decade: still the gold standard?

    Science.gov (United States)

    Ruaengsri, Chawannuch; Schill, Matthew R; Khiabani, Ali J; Schuessler, Richard B; Melby, Spencer J; Damiano, Ralph J

    2018-04-01

    Atrial fibrillation (AF) is the most common cardiac arrhythmia and the treatment options include medical treatment and catheter-based or surgical interventions. AF is a major cause of stroke, and its prevalence is increasing. The surgical treatment of AF has been revolutionized over the past 2 decades through surgical innovation and improvements in endoscopic imaging, ablation technology and surgical instrumentation. The Cox-maze (CM) procedure, which was developed by James Cox and introduced clinically in 1987, is a procedure in which multiple incisions are created in both the left and the right atria to eliminate AF while allowing the sinus impulse to reach the atrioventricular node. This procedure became the gold standard for the surgical treatment of AF. Its latest iteration is termed the CM IV and was introduced in 2002. The CM IV replaced the previous cut-and-sew method (CM III) by replacing most of the incisions with a combination of bipolar radiofrequency and cryoablation. The use of ablation technologies, made the CM IV technically easier, faster and more amenable to minimally invasive approaches. The aims of this article are to review the indications and preoperative planning for the CM IV, to describe the operative technique and to review the literature including comparisons of the CM IV with the previous cut-and-sew method. Finally, this review explores future directions for the surgical treatment of patients with AF.

  2. Calculation of the yearly energy performance of heating systems based on the European Building Energy Directive and related CEN Standards

    DEFF Research Database (Denmark)

    Olesen, Bjarne W.; de Carli, Michele

    2011-01-01

    According to the Energy Performance of Buildings Directive (EPBD) all new European buildings (residential, commercial, industrial, etc.) must since 2006 have an energy declaration based on the calculated energy performance of the building, including heating, ventilating, cooling and lighting syst......–20% of the building energy demand. The additional loss depends on the type of heat emitter, type of control, pump and boiler. Keywords: Heating systems; CEN standards; Energy performance; Calculation methods......According to the Energy Performance of Buildings Directive (EPBD) all new European buildings (residential, commercial, industrial, etc.) must since 2006 have an energy declaration based on the calculated energy performance of the building, including heating, ventilating, cooling and lighting...

  3. 1070 myeloablative megatherapy procedures followed by stem cell rescue for neuroblastoma: 17 years of European experience and conclusions

    Energy Technology Data Exchange (ETDEWEB)

    Chauvin, F. [Centre Leon Berard, Unit of Biostatistics, 28, rue Laennec, 69373 Lyon (France); Rosti, G. [Ospedale Civile, Oncologia Medica, Via Le Randi 5, 48100 Ravenna (Italy); Bernard, J.L. [Hopital d' Enfants de la Timone, Department of Paediatrics, Boulevard Jean Moulin, 13385 Marseille (France); Kremens, B. [Universitats Klinikum Essen, Department of Paediatrics, Hufelandstrasse, 55, 45122 Essen (Germany); Garaventa, A. [Istituto Giannina Gaslini, Department of Haematology/Oncology, Via Maggio 5, 16148 Genova Quarto (Italy); Klingebiel, T. [University Hospital, Abteilung Hamatologie Oncologie, Ruemelinstrasse 18-23, 7400 Tuebingen (Germany); Pearson, A.D.J. [Royal Victoria Infirmary, Sir J. Spence Institute of Child Health, Children' s Cancer Unit, Queen Victoria Road, Newcastle Upon Tyne (United Kingdom); Pinkerton, R. [The Royal Marsden Hospital, Children' s Department, Downs Road, Sutton (United Kingdom); Zucker, J.M. [Institut Curie, Department of Paediatrics, 3 rue Thuillier, 75231 Paris (France); Hartmann, O. [Institut Gustave Roussy, Department of Paediatrics, rue Camille Desmoulins, 94805 Villejuif (France); Lasset, C. [Centre Leon Berard, Unit of Biostatistics, 28, rue Laennec, 69373 Lyon (France); Ladenstein, R. [St. Anna Kinderhospital, Department of Haematology, Wiener Rotes Kreuz, Kinderspitalgasse 6, 1086 Vienna (Austria); Philip, T. [Centre Leon Berard, Department of Paediatrics, 28, rue Laennec, 69373 Lyon (France)

    1997-10-01

    1070 myeloablative procedures followed by stem cell rescue for neuroblastoma are reviewed. These 1070 procedures are part of the European Group for Blood and Marrow Transplant (EBMTG) registry from the last 17 years (in 4536 patients). In 1070 neuroblastoma patients, survival at 2 years was 49%, at 5 years, 33% and relapses were observed as late as 7 years post-BMT (bone marrow transplant). However, 5-year survivors after megatherapy with BMT for stage 4 disease do have an 80% chance of becoming a long-term survivor. When BMT had been used in first complete response (CR1) no salvage was possible, whereas 15% survivors may be seen if BMT is used for the first time at relapse. Infants with stage 4 neuroblastoma had a 17% toxic death rate and indication in this group is exceptional and not recommended. In a matched cohort (17 allogeneic and 34 autologous), autologous stem cell rescue (SCR) was shown to be at least equal to allogeneic SCR. Multivariate analysis of clinical prognostic factors in children with stage 4 disease over 1 year showed that event-free survival was mainly influenced by two adverse factors before the megatherapy procedure: persisting skeleton lesions ({sup 99}Tc and/or mIBG scan positive) as well as persisting bone marrow (BM) involvement. (Copyright (c) 1997 Elsevier Science B.V., Amsterdam. All rights reserved.)

  4. Development of a standard operating procedure for mammography equipment used in calibration of ionized chambers

    International Nuclear Information System (INIS)

    Rodrigues, Yklys Santos; Potiens, Maria da Penha Albuquerque

    2011-01-01

    Mammography is one widely used technique in the detection of breast cancer. In order to optimize the results achieving better images with lower dose rates, a quality assurance programme must be applied to the equipment. Some control tests use ionization chambers to measure air kerma and other quantities. These tests can only be reliable if the ionization chambers used on them are correctly calibrated. In the present work, it was developed a standard operating procedure (SOP) for quality control tests in a commercial mammography equipment installed in the Calibration Laboratory (LCI) at IPEN - Brazilian Institute for energy and nuclear research). Seven tests were performed in the equipment: Tube voltage and exposition time accuracy and reproducibility, linearity and reproducibility of Air kerma and Half Value Layer (HVL). Then, it was made a measurement of the air kerma in the mammography equipment, using a reference ionization chamber with traceability to a primary laboratory in Germany (Physikalisch-Technische Bundesanstalt - PTB), that was later compared with the air kerma measured in an industrial irradiator. This industrial X-ray generator was recently used in the implementation of X-radiation Standards beams, mammography level, following the Standard IEC 61267. The HVL values varied from 0.36 (25kV) to 0.41 mmA1 (35kV), and the measured air kerma rates were between 9.78 and 17.97 mGy/min. (author)

  5. Primary calibration of TXRF in comparison with the standard droplet procedure

    International Nuclear Information System (INIS)

    Dobler, M.; Reus, U.; Knoth, J.; Schwenke, H.

    2000-01-01

    For the determination of contamination on wafer surfaces with total reflection x-ray fluorescence spectrometry (TXRF) normally external 1 ng Ni droplet standards were used for calibration. This method is based on several assumptions about the properties of the standard droplet which are strongly affected by the preparation of the samples. In this paper a study is resented which compares the external droplet method with a calibration procedure using the fundamental physical background of total reflection x-ray fluorescence spectrometry and the properties of Ni bulk material. The particular features of the two methods will be discussed and the obtained results compared to each other. It is demonstrated in this study that the calibration with Ni bulk material is a primary method which offers several advantages compared to the calibration based on droplet standards. These advantages are unique and enable a more reliable and reproducible quantification of contamination on wafer surfaces. This is caused by the fact that the method is standardless and only based on fundamental parameters and natural constants. It is also demonstrated that effects which could be caused by especial features of the measured samples (particle or film, e.g.) or by the degradation of the calibration sample could be excluded. (author)

  6. Social protection of migrant workers in Ukraine: striving towards European standards under crisis

    OpenAIRE

    Nataliia FEDIRKO

    2015-01-01

    The article aims to analyse the state of social protection for migrant workers in Ukraine. We investigated the legal status of migrant workers in Ukraine and carried out a comparative analysis of national and European experience in the area of protection of migrant workers’ rights. The author provides grounded support for a set of administrative measures aimed to implement the rights of migrant workers as a part of Ukraine’s international and European commitments. The practical significance o...

  7. Influence of new customs procedures and logistic security standards on companies competiveness – a Croatian company case study

    Directory of Open Access Journals (Sweden)

    Aleksandar Erceg

    2014-12-01

    Full Text Available In today’s global market, companies are constantly confronted with the competition on the local, national and international level. Companies therefore use a variety of strategies and tools to become and/or remain competitive. Potential areas for cost reduction in companies are supply chain management and logistic and customs procedures. Implementation of various logistic standards in supply chain management can provide significant cost savings for the company’s daily operations and thus reduce overall costs and improve the competitiveness. Using different customs procedures and logistic standards to reduce their costs and become more competitive in the market is necessary for Croatian companies. The method of using these tools is not a one-time process and requires constant efforts. Companies therefore have to be ready to improve daily to be and remain competitive. Using a variety of modern customs procedures can save their money and time, not only through these procedures, but also through better use of their employee’s time, their own vehicles and other equipment. The paper analyzes various customs procedures and logistic standards that can help companies save time and money and improve their competitiveness. In the example of Croatian company, which uses various available procedures and standards the benefits of their use are shown. Apart from bringing savings in operations, all these procedures and standards allow the company to be better, cheaper and more attractive to buyers.

  8. Calibration of photon and beta ray sources used in brachytherapy. Guidelines on standardized procedures at Secondary Standards Dosimetry Laboratories

    International Nuclear Information System (INIS)

    2004-03-01

    It has generally been recognized that international harmonization in radiotherapy dosimetry is essential. Consequently, the IAEA has given much effort to this, for example by publishing a number of reports in the Technical Reports Series (TRS) for external beam dosimetry, most notably TRS-277 and more recently TRS-398. Both of these reports describe in detail the steps to be taken for absorbed dose determination in water and they are often referred to as 'dosimetry protocols'. Similar to TRS-277, it is expected that TRS-398 will be adopted or used as a model by a large number of countries as their national protocol. In 1996, the IAEA established a calibration service for low dose rate (LDR) 137 Cs brachytherapy sources, which is the most widely used source for treatment of gynecological cancer. To further enhance harmonization in brachytherapy dosimetry, the IAEA published in 1999 IAEA-TECDOC-1079 entitled 'Calibration of Brachytherapy Sources. Guidelines on Standardized Procedures for the Calibration of Brachytherapy Sources at Secondary Standard Dosimetry Laboratories (SSDLs) and Hospitals'. The report was well received and was distributed in a large number of copies to the members of the IAEA/WHO network of SSDLs and to medical physicists working with brachytherapy. The present report is an update of the aforementioned TECDOC. Whereas TECDOC-1079 described methods for calibrating brachytherapy sources with photon energies at or above those of 192 Ir, the current report has a wider scope in that it deals with standardization of calibration of all the most commonly used brachytherapy sources, including both photon and beta emitting sources. The latter sources have been in use for a few decades already, but their calibration methods have been unclear. Methods are also described for calibrating sources used in the rapidly growing field of cardiovascular angioplasty. In this application, irradiation of the vessel wall is done in an attempt to prevent restenosis after

  9. A Guide for Developing Standard Operating Job Procedures for the Grit Removal Process Wastewater Treatment Facility. SOJP No. 2.

    Science.gov (United States)

    Deal, Gerald A.; Montgomery, James A.

    This guide describes standard operating job procedures for the grit removal process of wastewater treatment plants. Step-by-step instructions are given for pre-start up inspection, start-up, continuous operation, and shut-down procedures. A description of the equipment used in the process is given. Some theoretical material is presented. (BB)

  10. Standard manufacturing procedure for syrup and tablet forms of Jwarahara Dashemani

    Science.gov (United States)

    Kalsariya, Bharat D.; Patgiri, B. J.; Prajapati, P. K.

    2010-01-01

    Jwarahara Dashemani (JHD) is mentioned by Acharya Charaka under the different categories of Mahakashayas (groups of drugs having similar pharmacological actions). For the present study, syrup and tablet forms of JHDs were prepared and analyzed. The formulations were prepared in various batches by following the standard manufacturing procedure (SMP). JHD Kwatha (2200 ml) and 1430 g sugar candy powder were heated (80–90°C) together for 3.10 hours and 2200 ml syrup was obtained, whereas an average of 446 g of tablet was obtained from the mixture of 285 g Ghana and powder of sugar candy (125 g), JHD Dravyas (55 g) and talc (18 g). These formulations were subjected to various analytical parameters and the results were observed on the basis of preparation. PMID:22131721

  11. The CIPM list of recommended frequency standard values: guidelines and procedures

    Science.gov (United States)

    Riehle, Fritz; Gill, Patrick; Arias, Felicitas; Robertsson, Lennart

    2018-04-01

    A list of standard reference frequency values (LoF) of quantum transitions from the microwave to the optical regime has been recommended by the International Committee for Weights and Measures (Comité international des poids et mesures, CIPM) for use in basic research, technology, and for the metrology of time, frequency and length. The CIPM LoF contains entries that are recommended as secondary representations of the second in the International System of Units, and entries that can be used to serve as realizations of the definition of the metre. The historical perspective that led to the CIPM LoF is outlined. Procedures have been developed for updating existing, and validating new, entries into the CIPM LoF. The CIPM LoF might serve as an entry for a future redefinition of the second by an optical transition.

  12. Standardization of the Action Verbs used in Emergency Operating Procedures of NPPs

    Energy Technology Data Exchange (ETDEWEB)

    Jang, Tong Il; Lee, Yong Hee; Park, Jae Chang [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Jeong, Yeon Seop; Chu, Gang Il [Korea Hydro and Nuclear Power, Daejeon (Korea, Republic of)

    2010-05-15

    The action verbs used in Emergency Operating Procedures (EOPs) for each nuclear power plant are translated respectively from the action verbs used in Emergency Recovery Guidelines (ERG) of the reference plants. The action verbs used in each plant are not largely different with one another. There are, however, some cases that the meanings of the same action verbs used in different plants are not consistent with each other and translations are not exact. In this study, the original English expressions of the action verbs and the translated verbs were compared and their accepted meanings analyzed. And then, standardization for the action verbs which are not exactly translated or which are used with different meanings among the plants was proposed

  13. Constructing an exposure chart: step by step (based on standard procedures)

    International Nuclear Information System (INIS)

    David, Jocelyn L; Cansino, Percedita T.; Taguibao, Angileo P.

    2000-01-01

    An exposure chart is very important in conducting radiographic inspection of materials. By using an accurate exposure chart, an inspector is able to avoid a trial and error way of determining correct time to expose a specimen, thereby producing a radiograph that has an acceptable density based on a standard. The chart gives the following information: x-ray machine model and brand, distance of the x-ray tube from the film, type and thickness of intensifying screens, film type, radiograph density, and film processing conditions. The methods of preparing an exposure chart are available in existing radiographic testing manuals. These described methods are presented in step by step procedures, covering the actual laboratory set-up, data gathering, computations, and transformation of derived data into Characteristic Curve and Exposure Chart

  14. Evaluation of human exposure to complex waveform magnetic fields generated by arc-welding equipment according to European safety standards.

    Science.gov (United States)

    Zoppetti, Nicola; Bogi, Andrea; Pinto, Iole; Andreuccetti, Daniele

    2015-02-01

    In this paper, a procedure is described for the assessment of human exposure to magnetic fields with complex waveforms generated by arc-welding equipment. The work moves from the analysis of relevant guidelines and technical standards, underlining their strengths and their limits. Then, the procedure is described with particular attention to the techniques used to treat complex waveform fields. Finally, the procedure is applied to concrete cases encountered in the workplace. The discussion of the results highlights the critical points in the procedure, as well as those related to the evolution of the technical and exposure standards. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  15. Development of a standard test procedure for devices on thermal weed control

    Directory of Open Access Journals (Sweden)

    Verschwele, Arnd

    2016-02-01

    Full Text Available In contrast to the standard evaluation of the efficacy of pesticides and the testing of spraying equipment there are no comparable testing procedure for equipment of thermal weed control. It is the aim of the investigations described here to develop a standard procedure for assessing temperature distribution and biological efficacy. This will be the basis for quality testing which can be directly used by practical users. Also it can help engineers to improve devices if constructive gaps will be identified by these tests. The results from testing a flaming device (Green-Flame 850 E demonstrated such a potential for technical improvement: The temperature decreased from 159 °C to 89 °C by increasing driving speed from 0.35 m/s to 0.81 m/s. The variation of the temperature related to the working width was extremely high: The range was 60 °C at highest speed and 79 °C at lowest speed, respectively. The biological efficacy against the test plant species Sinapis arvensis was also affected by the driving speed and the corresponding temperature. A driving speed not higher than 0.53 m/s resulted in efficacy rates of almost 95%. However, the efficacy was only 66% at the highest tested speed of 0.81 m/s. Thus, the needed effective temperature is between 89 °C und 106 °C. In contrast, Lolium perenne was controlled by only 72% under the tested conditions. Here a dose-response relationship was not observed. The variation of the temperature, as well as the biological efficacy, was extremely heterogeneous and not satisfying in terms of an economic and safe use. Similar results were found for other devices on thermal weed control.

  16. Standard Operating Procedure (SOP) for Rapid and Efficient Production of Stevia Tissue Culture Seedlings

    International Nuclear Information System (INIS)

    Norazlina Noordin; Peng, C.S.; Rusli Ibrahim

    2015-01-01

    Stevia rebaudiana Bertoni is a non-caloric natural sweetener which is 300 times sweeter than cane sugar. Extracts from stevia leaves has vast application in food and beverages based industries, can be added to tea and coffee, cooked or baked goods, processed foods and confectionary goods. Recently, stevia attained awareness owing to its natural, non-caloric sweetness by diet/ health conscious and diabetic persons (Arpita et al., 2011). This natural sweetener has high commercial value in global market, it was estimated that global market value for stevia is be around USD11 billion by year 2015. Although stevia is being largely popularized in Malaysia and other countries but large-scale propagation procedures for the continuous supply of planting materials in commercial plantation has yet to be established, optimized and standardized. Furthermore, propagation through stevia seeds is often very difficult due to self-incompatibility which results in sterile seeds (Sakaguchi et al., 1982). Tissue culture is the only rapid process for the mass propagation of stevia and there have been few reports of in vitro growth of stevia (Miyagaya et al., 1986) and in vitro micropropagation from shoot tip and leaf (Uddin et al., 2006). Hence, study was carried out to establish a suitable protocol for in vitro propagation of S. rebaudiana Bertoni that can be further up-scaled for mass propagation of stevia seedlings. The established Standard Operating Procedure (SOP) will ensure rapid and efficient production of stevia tissue culture seedlings for continuous supply of planting materials for commercial stevia plantations in Malaysia. Preparation of growth medium, multiplication of shoots, rooting of plant lets and hardening of ex-vitro rooted plant lets is discussed in this paper. (author)

  17. The importance of strong evaluation standards and procedures in training residents.

    Science.gov (United States)

    Short, J P

    1993-07-01

    A strong evaluation process in a residency offers faculty an opportunity to strengthen the educational program, to help residents know what is expected of them, and to remove with minimum difficulties those residents who are not progressing satisfactorily and do not appear to be salvageable. Despite these advantages, the evaluation of residents during their training is often done poorly or not at all. The author describes the kinds of standards and procedures that constitute a sound, strong evaluation process, proposes criteria for academic probation and due process when a resident is performing unacceptably, and describes the role that the medical school administration should play in the evaluation process, one that is flexible enough to allow each program to comply and still have program-specific procedures. The author closes with statistics on how few residents are dismissed for incompetency or unacceptable behaviors, and inquires how many more might be found if strong evaluation processes were more widely used. Even so, in the attempt to evaluate residents and to foster protection from legal problems, residency program directors must keep in mind the importance of letting residents make mistakes and learn from them; a good evaluation system strikes a balance that fosters the learning process and benefits the residents, the medical school, and the community.

  18. THE CRITICAL THINKING OF SOME WESTERN EUROPEAN CORPORATE GOVERNANCE STANDARDS AFTER FINANCIAL CRISIS, CORPORATE SCANDALS AND MANIPULATION

    OpenAIRE

    Dinh TRAN NGOC HUY

    2013-01-01

    After the recent global crisis, corporate scandals and bankruptcy in US and Europe, there is some certain evidence on weak auditing, risk management, accounting and audit system. This paper chooses a different analytical approach and among its aims is to give some systematic opinions on corporate governance criteria as a benchmark for stock markets. Firstly, it classifies limited Western European representative corporate governance (CG) standards into two (2) groups: The Netherlands and Belgi...

  19. Collection of Pyrethroids in Water and Sediment Matrices: Development and Validation of a Standard Operating Procedure

    Science.gov (United States)

    Hladik, Michelle; Orlando, James L.; Kuivila, Kathryn

    2009-01-01

    Loss of pyrethroid insecticides onto surfaces during sample collection can confound the interpretation of analytical and toxicity test results. Sample collection devices, container materials, and water matrix composition have a significant influence on the association of pyrethroids to container walls, which can be as high as 50 percent. Any sample collection method involving transfer through multiple containers or pieces of equipment increases the potential for pyrethroid loss. This loose 'surface-association' with container walls can be reversed through agitation. When sampling water matrices with pumps or autosamplers, no pyrethroids were lost as long as the water was moving continuously through the system. When collecting water matrices in containers, the material with the least amount of pyrethroid sorption is as follows: glass less than (pyrethroids were easier to re-suspend from the glass container walls. Since the amount of surface-association is proportional to the ratio of volume-to-contact-area of the sample, taking larger-volume field samples (greater than 3 liters) reduced pyrethroid losses to less than 10 percent. The amount of surface-association cannot be predicted easily because of the dependence on water matrix composition; samples with higher dissolved organic carbon or suspended-sediment concentrations were observed to have lower percent loss. Sediment samples were not affected by glass-container sorption (the only containers tested). Standardized sample-collection protocols are critical to yield accurate pyrethroid concentrations for assessment of potential effects, and have been summarized in an accompanying standard operating procedure.

  20. Enhanced Sanitation Standard Operating Procedures Have Limited Impact on Listeria monocytogenes Prevalence in Retail Delis.

    Science.gov (United States)

    Etter, Andrea J; Hammons, Susan R; Roof, Sherry; Simmons, Courtenay; Wu, Tongyu; Cook, Peter W; Katubig, Alex; Stasiewicz, Matthew J; Wright, Emily; Warchocki, Steven; Hollingworth, Jill; Thesmar, Hilary S; Ibrahim, Salam A; Wiedmann, Martin; Oliver, Haley F

    2017-10-20

    In a recent longitudinal surveillance study in 30 U.S. retail delicatessens, 9.7% of environmental surfaces were positive for Listeria monocytogenes, and we found substantial evidence of persistence. In this study, we aimed to reduce the prevalence and persistence of L. monocytogenes in the retail deli environment by developing and implementing practical and feasible intervention strategies (i.e., sanitation standard operating procedures; SSOPs). These SSOPs were standardized across the 30 delis enrolled in this study. SSOP implementation was verified by systems inherent to each retailer. Each deli also was equipped with ATP monitoring systems to verify effective sanitation. We evaluated intervention strategy efficacy by testing 28 food and nonfood contact surfaces for L. monocytogenes for 6 months in all 30 retail delis. The efficacy of the intervention on the delis compared with preintervention prevalence level was not statistically significant; we found that L. monocytogenes could persist despite implementation of enhanced SSOPs. Systematic and accurate use of ATP monitoring systems varied widely among delis. The findings indicate that intervention strategies in the form of enhanced daily SSOPs were not sufficient to eliminate L. monocytogenes from highly prevalent and persistently contaminated delis and that more aggressive strategies (e.g., deep cleaning or capital investment in redesign or equipment) may be necessary to fully mitigate persistent contamination.

  1. Leptospirosis in a small animal veterinarian: reminder to follow standardized infection control procedures.

    Science.gov (United States)

    Baer, R; Turnberg, W; Yu, D; Wohrle, R

    2010-06-01

    A small animal veterinarian in Washington State developed leptospirosis after an occupational exposure. Approximately 10 days prior to the onset of illness, he examined a healthy appearing pet rat for fleas, which urinated on his un-gloved hands. Although the veterinarian washed his hands after the examination, his hands had abrasions from gardening. The veterinarian was hospitalized for 12 days and was able to return to work part-time 1 month following discharge. This illness may have been prevented if the veterinarian had been wearing gloves during the examination as recommended by the National Association of State Public Health Veterinarians (NASPHV), Veterinary Infection Control Committee, in its Compendium of Veterinary Standard Precautions for Zoonotic Disease Prevention in Veterinary Personnel (2008). This case alerts us to the need for small animal veterinarians to minimize their infection risk by practising recommended infection control procedures. Veterinarians should establish and follow a written infection control plan based on the standardized infection control approach adopted by the NASPHV to minimize their risk of occupational zoonotic infections.

  2. CSNI international standard problem procedures - CSNI Report No. 17 - Revision 4

    International Nuclear Information System (INIS)

    Micaelli, J.C.

    2004-01-01

    . Careful consideration and planning is therefore required. After a brief recall of the ISPs' objectives, this document provides guidelines to be followed during the different phases of an ISP. Two phases are considered. The first one consists in proposing and selecting an ISP, the second one consists in performing an ISP. This revised document was prepared under the Leadership of J.-C. Micaelli (IRSN). It was reviewed and endorsed in September 2003 by the Working Group on the Analysis and Management of Accidents (GAMA), GAMA performed in 2003 a survey on updating CSNI Report No. 17, 'CSNI Standard Problem Procedures', first published in 1977, last updated in 1989. The objective of this activity was to collect proposals regarding the improvement of ISP efficiency with respect to their objectives and the improvement of the quality of the procedures document. Eleven series of questions were asked in the survey, related to: - General structure of the procedures document; - ISP objectives; - Six phases: ISP proposal, ISP specification, ISP results reporting, Preparation of the preliminary data comparison and interpretation report, Post-ISP analysis, Preparation of the final comparison and interpretation report; - Updating of the procedures; - Support to be provided by the participants

  3. Practicability of passenger vehicle driving emission tests according to new European Union procedures

    Directory of Open Access Journals (Sweden)

    Pielecha Jacek

    2017-01-01

    Full Text Available The article compares driving test data using the latest legislative proposals applicable to passenger cars. Several measurements were performed on the same test route in accordance with the RDE test guidelines, which requires a number of criteria to be met. These criteria include: the length of the measuring segments, their overall test time share, and the dynamic characteristics of the drive. A mobile device for reading the EOBD System information was used to record the engine and vehicle operating parameters during tests. This allowed for the monitoring of parameters such as: load value, engine speed and vehicle velocity. The obtained results were then analyzed for their compatibility with the RDE procedure requirements. Despite the same research route, the obtained results were not the same. The analysis also uses the two-dimensional operating time share characteristics expressed in vehicle velocity and acceleration co-ordinates. As a result it was possible to compare the dynamic properties, share of operating time and, consequently, to check the validity of conducted drive tests in terms of their practicability and emission values.

  4. A standard operating procedure for the surgical implantation of transmitters in juvenile salmonids

    Science.gov (United States)

    Liedtke, T.L.; Beeman, J.W.; Gee, L.P.

    2012-01-01

    Biotelemetry is a useful tool to monitor the movements of animals and is widely applied in fisheries research. Radio or acoustic technology can be used, depending on the study design and the environmental conditions in the study area. A broad definition of telemetry also includes the use of Passive Integrated Transponder (PIT) tags, either separately or with a radio or acoustic transmitter. To use telemetry, fish must be equipped with a transmitter. Although there are several attachment procedures available, surgical implantation of transmitters in the abdominal cavity is recognized as the best technique for long-term telemetry studies in general (Stasko and Pincock, 1977; Winter, 1996; Jepsen, 2003), and specifically for juvenile salmonids, Oncorhynchus spp. (Adams and others, 1998a, 1998b; Martinelli and others, 1998; Hall and others, 2009). Studies that use telemetry assume that the processes by which the animals are captured, handled, and tagged, as well as the act of carrying the transmitter, will have minimal effect on their behavior and performance. This assumption, commonly stated as a lack of transmitter effects, must be valid if telemetry studies are to describe accurately the movements and behavior of an entire population of interest, rather than the subset of that population that carries transmitters. This document describes a standard operating procedure (SOP) for surgical implantation of radio or acoustic transmitters in juvenile salmonids. The procedures were developed from a broad base of published information, laboratory experiments, and practical experience in tagging thousands of fish for numerous studies of juvenile salmon movements near Columbia River and Snake River hydroelectric dams. Staff from the Western Fisheries Research Center's Columbia River Research Laboratory (CRRL) frequently have used telemetry studies to evaluate new structures or operations at hydroelectric dams in the Columbia River Basin, and these evaluations typically

  5. 77 FR 65823 - Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

    Science.gov (United States)

    2012-10-31

    ... Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures... titled ``Table 3 to Sec. 87.23--Tier 6 NO X Standards for New Subsonic Turbofan or Turbojet Engines with... for New Subsonic Turbofan or Turbojet Engines With Rated Output Above 26.7 kN and the rated output (in...

  6. Acucise™ endopyelotomy in a porcine model: procedure standardization and analysis of safety and immediate efficacy

    Directory of Open Access Journals (Sweden)

    Andreoni Cássio

    2004-01-01

    Full Text Available PURPOSE: The study here presented was done to test the technical reliability and immediate efficacy of the Acucise device using a standardized technique. MATERIALS AND METHODS: 56 Acucise procedures were performed in pigs by a single surgeon who used a standardized technique: insert 5F angiographic catheter bilaterally up to the midureter, perform retrograde pyelogram, Amplatz super-stiff guidewire is advanced up to the level of the renal pelvis, angiographic catheters are removed, Acucise catheter balloon is advanced to the ureteropelvic junction (UPJ level, the super-stiff guide-wire is removed and the contrast medium in the renal pelvis is aspirated and replaced with distilled water, activate Acucise at 75 watts of pure cutting current, keep the balloon fully inflated for 10 minutes, perform retrograde ureteropyelogram to document extravasation, remove Acucise catheter and pass an ureteral stent and remove guide-wire. RESULTS: In no case did the Acucise device present malfunction. The electrocautery activation time was 2.2 seconds (ranging from 2 to 4 seconds. The extravasation of contrast medium, visible by fluoroscopy, occurred in 53 of the 56 cases (94.6%. In no case there was any evidence of intraoperative hemorrhage. CONCLUSIONS: This study revealed that performing Acucise endopyelotomy routinely in a standardized manner could largely preclude intraoperative device malfunction and eliminate complications while achieving a successful incision in the UPJ. With the guidelines that were used in this study, we believe that Acucise endopyelotomy can be completed successfully and safely in the majority of selected patients with UPJ obstruction.

  7. The role of the article 31 experts group in harmonising the standards for radiation protection in the European Union

    International Nuclear Information System (INIS)

    Govaerts, P.

    2002-01-01

    Article 2 of the Euratom (European Atomic Energy Community) treaty requires the establishment of uniform safety standards to be implemented by each member state: Article 2, b: In order to perform its task the community shall establish uniform safety standards to protect the health of workers and of the general public and ensure that they are applied. The scope of those standards is defined by Article 30 and relates to doses compatible with adequate safety; levels of exposure and contamination; the fundamental principles governing the health surveillance of workers. Article 31 stipulates the decision making process with respect to those standards. Article 31: The basic standards shall be worked out by the Commission after it has obtained the opinion of a group of persons appointed by the Scientific and Technical Committee from among scientific experts, and in particular public health experts, in the Member States. The Commission shall obtain the opinion of the Economic and Social Committee on these basic standards. After consulting the Assembly the Council shall, on a proposal from the Commission, which shall forward to it the opinions from these Committees, establish the basic safety standards; the Council shall act by a qualified majority

  8. Manual of Standard Operating Procedures for Veterinary Drug Residue Analysis (French Edition)

    International Nuclear Information System (INIS)

    2017-01-01

    Laboratories are crucial to national veterinary drug residue monitoring programmes. However, one of the main challenges laboratories encounter is obtaining access to relevant methods of analysis. Thus, in addition to training, providing technical advice and transferring technology, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has resolved to develop clear and practical manuals to support Member State laboratories. The Coordinated Research Project (CRP) on Development of Radiometric and Allied Analytical Methods to Strengthen Residue Control Programs for Antibiotic and Anthelmintic Veterinary Drug Residues has developed a number of analytical methods as standard operating procedures (SOPs), which are now compiled here. This publication contains SOPs on chromatographic and spectrometric techniques, as well as radioimmunoassay and associated screening techniques, for various anthelmintic and antimicrobial veterinary drug residue analysis. Some analytical method validation protocols are also included. The publication is primarily aimed at food and environmental safety laboratories involved in testing veterinary drug residues, including under organized national residue monitoring programmes. It is expected to enhance laboratory capacity building and competence through the use of radiometric and complementary tools and techniques. The publication is also relevant for applied research on residues of veterinary drugs in food and environmental samples

  9. Standard operating procedures for quality audits of 60Co external beam radiotherapy facilities

    International Nuclear Information System (INIS)

    Larrinaga Cortina, E.F.; Dominguez Hung, L.; Campa Menendez, R.

    2001-01-01

    The use of radiotherapy implies the necessity of rigorous quality standards in its different components, aimed to provide the best possible treatment and avoid potential patients' risks, that could even cause him death. Projects of technical cooperation developed in Cuba and supported by the International Atomic Energy Agency address the implementation of Programs of Quality Assurance (PGC) in radiotherapy services. The establishment of the National Quality Audit Program (PNAC) is a superior stage. The National Control Center for Medical Devices, as the national regulator entity for the control and supervision of medical devices in the National Health System, is responsible for the making and execution of the PNAC. The audit modality selected was the inspection visit in situ due to its intrinsic advantages, our geographical extension and the number of radiotherapy services. This paper presents the methodology for the execution of the PNAC, in form of a Normalized Procedure of Operation (PNO) that defines the objectives, scope, terms and definitions, responsibilities, composition and selection of the auditor team, security's conditions, materials and equipment, steps of the audit execution, results calculation and interpretation, records, etc. (author)

  10. Manual of Standard Operating Procedures for Veterinary Drug Residue Analysis (Spanish Edition)

    International Nuclear Information System (INIS)

    2017-01-01

    Laboratories are crucial to national veterinary drug residue monitoring programmes. However, one of the main challenges laboratories encounter is obtaining access to relevant methods of analysis. Thus, in addition to training, providing technical advice and transferring technology, the Joint FAO/IAEA Division of Nuclear Techniques in Food and Agriculture has resolved to develop clear and practical manuals to support Member State laboratories. The Coordinated Research Project (CRP) on Development of Radiometric and Allied Analytical Methods to Strengthen Residue Control Programs for Antibiotic and Anthelmintic Veterinary Drug Residues has developed a number of analytical methods as standard operating procedures (SOPs), which are now compiled here. This publication contains SOPs on chromatographic and spectrometric techniques, as well as radioimmunoassay and associated screening techniques, for various anthelmintic and antimicrobial veterinary drug residue analysis. Some analytical method validation protocols are also included. The publication is primarily aimed at food and environmental safety laboratories involved in testing veterinary drug residues, including under organized national residue monitoring programmes. It is expected to enhance laboratory capacity building and competence through the use of radiometric and complementary tools and techniques. The publication is also relevant for applied research on residues of veterinary drugs in food and environmental samples

  11. Qualitative research within trials: developing a standard operating procedure for a clinical trials unit

    Science.gov (United States)

    2013-01-01

    Background Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Methods Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). Results The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. Conclusions We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials. PMID:23433341

  12. Qualitative research within trials: developing a standard operating procedure for a clinical trials unit.

    Science.gov (United States)

    Rapport, Frances; Storey, Mel; Porter, Alison; Snooks, Helen; Jones, Kerina; Peconi, Julie; Sánchez, Antonio; Siebert, Stefan; Thorne, Kym; Clement, Clare; Russell, Ian

    2013-02-21

    Qualitative research methods are increasingly used within clinical trials to address broader research questions than can be addressed by quantitative methods alone. These methods enable health professionals, service users, and other stakeholders to contribute their views and experiences to evaluation of healthcare treatments, interventions, or policies, and influence the design of trials. Qualitative data often contribute information that is better able to reform policy or influence design. Health services researchers, including trialists, clinicians, and qualitative researchers, worked collaboratively to develop a comprehensive portfolio of standard operating procedures (SOPs) for the West Wales Organisation for Rigorous Trials in Health (WWORTH), a clinical trials unit (CTU) at Swansea University, which has recently achieved registration with the UK Clinical Research Collaboration (UKCRC). Although the UKCRC requires a total of 25 SOPs from registered CTUs, WWORTH chose to add an additional qualitative-methods SOP (QM-SOP). The qualitative methods SOP (QM-SOP) defines good practice in designing and implementing qualitative components of trials, while allowing flexibility of approach and method. Its basic principles are that: qualitative researchers should be contributors from the start of trials with qualitative potential; the qualitative component should have clear aims; and the main study publication should report on the qualitative component. We recommend that CTUs consider developing a QM-SOP to enhance the conduct of quantitative trials by adding qualitative data and analysis. We judge that this improves the value of quantitative trials, and contributes to the future development of multi-method trials.

  13. Implementation in Russia and the European Union of International Safety Standards of Identity Documents with Biometric Data: Legal Regulation and Perspectives

    Directory of Open Access Journals (Sweden)

    Alexander Grigoryevich Volevodz

    2015-01-01

    Full Text Available The article contains the findings of a research into particular aspects of use of identity documents with personal biometric data. It considers the international safety standards of documents with biometric data worked out by the International Civil Aviation Organization (ICAO, pursuant to which those data should be included into machine-readable documents used by their holders for travel to various states. It contains the information on the implementation of these international standards in Russian and European Union law. The author has substantiated a conclusion to the effect that the procedure established in Russia for production and issuance, as well as for use of international, diplomatic and service passports identifying the Russian Federation citizen outside the Russian Federation territory, containing electronic information carriers with personal and biometric personal data, currently conforms to the international safety standards of documents with biometric data. The article surveys the experience of introducing domestic biometric identity documents - electronic passports in various countries of the world, and the problems arising therefrom. It substantiates the advantages and disadvantages of determining a passport of the Russian Federation citizen issued in the form of an identity card with an electronic information carrier, as the main document of the Russian Federation citizen identifying him domestically within the country's territory.

  14. Social protection of migrant workers in Ukraine: striving towards European standards under crisis

    Directory of Open Access Journals (Sweden)

    Nataliia FEDIRKO

    2015-12-01

    Full Text Available The article aims to analyse the state of social protection for migrant workers in Ukraine. We investigated the legal status of migrant workers in Ukraine and carried out a comparative analysis of national and European experience in the area of protection of migrant workers’ rights. The author provides grounded support for a set of administrative measures aimed to implement the rights of migrant workers as a part of Ukraine’s international and European commitments. The practical significance of the article lies in the evaluation of Ukraine’s readiness to ratify Article 19 of the European Social Charter (revised “The right of migrant workers and their families to protection and assistance”. The author analyses the influence of the socio-political and economic crisis in Ukraine on the processes of external and internal migration, and on the social protection policies in the area of forced migrants. Also, the study assesses the social assistance provided to internally displaced persons. Finally, it suggests complex measures designed to counteract the negative migration trend.

  15. Study approach and field work procedures of the MentDis_ICF65+ project on the prevalence of mental disorders in the older adult European population.

    Science.gov (United States)

    Volkert, Jana; Härter, Martin; Dehoust, Maria Christina; Schulz, Holger; Sehner, Susanne; Suling, Anna; Wegscheider, Karl; Ausín, Berta; Canuto, Alessandra; Crawford, Mike J; Da Ronch, Chiara; Grassi, Luigi; Hershkovitz, Yael; Muñoz, Manuel; Quirk, Alan; Rotenstein, Ora; Santos-Olmo, Ana Belén; Shalev, Arieh Y; Strehle, Jens; Weber, Kerstin; Wittchen, Hans-Ulrich; Andreas, Sylke

    2017-11-16

    This study describes the study approach and field procedures of the MentDis_ICF65+ study, which aims to assess the prevalence of mental disorders in older adults. An age-appropriate version of the Composite International Diagnostic Interview (CIDI65+) was developed and tested with regard to its feasibility and psychometric properties in a pre-test and pilot phase. In the cross-sectional survey an age-stratified, random sample of older adults (65-84 years) living in selected catchment areas of five European countries and Israel was recruited. N = 3142 participants (mean age 73.7 years, 50.7% female) took part in face-to-face interviews. The mean response rate was 20% and varied significantly between centres, age and gender groups. Sociodemographic differences between the study centres appeared for the place of birth, number of grandchildren, close significants, retirement and self-rated financial situation. The comparison of the MentDis_ICF65+ sample with the catchment area and country population of the study centres revealed significant differences, although most of these were numerically small. The study will generate new information on the prevalence of common mental disorders among older adults across Europe using an age-appropriate, standardized diagnostic instrument and a harmonized approach to sampling. Generalizability of the findings and a potentially limited representativeness are discussed.

  16. Control of Standard Terms in Consumer Contracts in Vietnamese Law: Lessons Learnt from European Experiences

    NARCIS (Netherlands)

    Do Giang, N.|info:eu-repo/dai/nl/370632516

    2017-01-01

    Nowadays, standard form consumer contracts are so ubiquitous in the modern society that a person virtually cannot participate in ordinary life without them. However, the major disadvantages of standard form contracts are that they lack meaningful consent, and they are unfair to the detriment of the

  17. Fractionation of potentially toxic elements in urban soils from five European cities by means of a harmonised sequential extraction procedure

    International Nuclear Information System (INIS)

    Davidson, Christine M.; Urquhart, Graham J.; Ajmone-Marsan, Franco; Biasioli, Mattia; Costa Duarte, Armando da; Diaz-Barrientos, Encarnacion; Grcman, Helena; Hossack, Iain; Hursthouse, Andrew S.; Madrid, Luis; Rodrigues, Sonia; Zupan, Marko

    2006-01-01

    The revised (four-step) BCR sequential extraction procedure has been applied to fractionate the chromium, copper, iron, manganese, nickel, lead and zinc contents in urban soil samples from public-access areas in five European cities. A preliminary inter-laboratory comparison was conducted and showed that data obtained by different laboratories participating in the study were sufficiently harmonious for comparisons to be made between cities and land types (e.g. parks, roadside, riverbanks, etc.). Analyte recoveries by sequential extraction, with respect to direct aqua regia digestion, were generally acceptable (100 ± 15%). Iron, nickel and, at most sites, chromium were found mainly in association with the residual phase of the soil matrix. Copper was present in the reducible, oxidisable and residual fractions, whilst zinc was found in all four sequential extracts. Manganese was strongly associated with reducible material as, in some cities, was lead. This is of concern because high lead concentrations were present in some soils (>500 mg kg -1 ) and the potential exists for remobilisation under reducing conditions. As would be expected, extractable metal contents were generally highest in older, more heavily industrialised cities. Copper, lead and zinc showed marked (and often correlated) variations in concentrations between sites within the same city whereas manganese and, especially, iron, did not. No overall relationships were, however, found between analyte concentrations and land use, nor between analyte partitioning and land use

  18. Validity evidence for procedural competency in virtual reality robotic simulation, establishing a credible pass/fail standard for the vaginal cuff closure procedure.

    Science.gov (United States)

    Hovgaard, Lisette Hvid; Andersen, Steven Arild Wuyts; Konge, Lars; Dalsgaard, Torur; Larsen, Christian Rifbjerg

    2018-03-30

    The use of robotic surgery for minimally invasive procedures has increased considerably over the last decade. Robotic surgery has potential advantages compared to laparoscopic surgery but also requires new skills. Using virtual reality (VR) simulation to facilitate the acquisition of these new skills could potentially benefit training of robotic surgical skills and also be a crucial step in developing a robotic surgical training curriculum. The study's objective was to establish validity evidence for a simulation-based test for procedural competency for the vaginal cuff closure procedure that can be used in a future simulation-based, mastery learning training curriculum. Eleven novice gynaecological surgeons without prior robotic experience and 11 experienced gynaecological robotic surgeons (> 30 robotic procedures) were recruited. After familiarization with the VR simulator, participants completed the module 'Guided Vaginal Cuff Closure' six times. Validity evidence was investigated for 18 preselected simulator metrics. The internal consistency was assessed using Cronbach's alpha and a composite score was calculated based on metrics with significant discriminative ability between the two groups. Finally, a pass/fail standard was established using the contrasting groups' method. The experienced surgeons significantly outperformed the novice surgeons on 6 of the 18 metrics. The internal consistency was 0.58 (Cronbach's alpha). The experienced surgeons' mean composite score for all six repetitions were significantly better than the novice surgeons' (76.1 vs. 63.0, respectively, p negatives). Our study has gathered validity evidence for a simulation-based test for procedural robotic surgical competency in the vaginal cuff closure procedure and established a credible pass/fail standard for future proficiency-based training.

  19. Calculation of the yearly energy performance of heating systems based on the European Building Directive and related CEN Standards

    DEFF Research Database (Denmark)

    Olesen, Bjarne W.; Langkilde, Gunnar

    2009-01-01

    In 2003 the European Commission (EC) issued a directive, 2002/91/EC [1]. The objective of this directive is to promote the improvement of the energy performance of buildings within the community, taking into account outdoor climatic and local conditions, as well as indoor climate requirements...... and ventilation systems must be performed. The present paper will present the method for calculating the energy performance for heating systems. The relevant CEN-standards are presented and a sample calculation of energy performance is made for a small family house in different geographical locations: Stockholm...

  20. Pandemic risk prevention in European countries: role of the ECDC in preparing for pandemics. Development and experience with a national self-assessment procedure, 2005-2008.

    Science.gov (United States)

    Nicoll, A

    2010-12-01

    To be effective risk prevention work takes place well before pandemics through the three Ps: Planning, Preparedness and Practise. Between 2005 and 2008 the European Centre for Disease Prevention and Control (ECDC) worked with the European Commission (EC) and the WHO Regional Office for Europe (WHO-Euro) to assist European countries in preparing themselves for a future influenza pandemic. All eligible countries in the European Union and European Economic Area participated with energy and commitment. Indicators of preparedness were developed based on WHO planning guidance and these were set within a simple assessment which included a formal country visit. The procedure evolved considerably with field experience. As the complexity of pandemic preparedness was appreciated it changed from being a classical short external assessment to longer national self-assessments with demonstrable impact, especially when self-assessments were published. There were essential supporting activities undertaken including a series of pan-European pandemic preparedness workshops organised by EC, WHO-Euro, ECDC and countries holding the European Union Presidency. The self-assessments highlighted additional work and documentation that was needed by national authorities from the ECDC. This work was undertaken and the document produced. The benefits of the self-assessments were seen in the 2009 pandemic in that EU/EEA countries performed better than some others. A number of the guidance documents were updated to fit the specific features of the pandemic. However the pandemic revealed many weaknesses and brought new challenges for European countries, notably over communication and vaccines, the need to prepare for a variety of scenarios and to factor severity estimates into preparedness, to improve surveillance for severe disease and to deliver seroepidemiology. Any revised self-assessment procedure will need to respond to these challenges.

  1. Influence of the Thermal Inertia in the European Simplified Procedures for the Assessment of Buildings’ Energy Performance

    Directory of Open Access Journals (Sweden)

    Luca Evangelisti

    2014-07-01

    Full Text Available This study aims to highlight the importance of thermal inertia in buildings. Nowadays, it is possible to use energy analysis software to simulate the building energy performance. Considering Italian standards, these analyses are based on the UNI TS 11300 that defines the procedures for the national implementation of the UNI EN ISO 13790. These standards require an energy analysis under steady-state condition, underestimating the thermal inertia of the building. In order to understand the inertial behavior of walls, a cubic Test-Cell was modelled through the dynamic calculation code TRNSYS and three different wall types were tested. Different stratigraphies, characterized by the same thermal transmittance value, composed by massive elements and insulating layers in different order, were simulated. Through TRNSYS, it was possible to define maximum surface temperatures and to calculate thermal lag between maximum values, both external and internal. Moreover, the attenuation between external surface temperatures and internal ones during summer (July was calculated. Finally, the comparison between Test-Cell’s annual energy demands, performed by using a commercial code based on the Italian standard UNITS 11300 and the dynamic code, TRNSYS, was carried out.

  2. Chapter 1. Introduction. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster.

    Science.gov (United States)

    Sprung, Charles L; Cohen, Robert; Adini, Bruria

    2010-04-01

    In December 2007, the European Society of Intensive Care Medicine established a Task Force to develop standard operating procedures (SOPs) for operating intensive care units (ICU) during an influenza epidemic or mass disaster. To provide direction for health care professionals in the preparation and management of emergency ICU situations during an influenza epidemic or mass disaster, standardize activities, and promote coordination and communication among the medical teams. Based on a literature review and contributions of content experts, a list of essential categories for managing emergency situations in the ICU were identified. Based on three cycles of a modified Delphi process, consensus was achieved regarding the categories. A primary author along with an expert group drafted SOPs for each category. Based on the Delphi cycles, the following key topics were found to be important for emergency preparedness: triage, infrastructure, essential equipment, manpower, protection of staff and patients, medical procedures, hospital policy, coordination and collaboration with interface units, registration and reporting, administrative policies and education. The draft SOPs serve as benchmarks for emergency preparedness and response of ICUs to emergencies or outbreak of pandemics.

  3. 24 CFR 200.942 - Supplementary specific procedural requirements under HUD building product standards and...

    Science.gov (United States)

    2010-04-01

    ... the following standards: (i) AATCC 20A-81—Fiber Analysis: Quantitative; (ii) AATCC 16E-82... Energy Source; (viii) ASTM D2646-79—Standard Methods of Testing Backing Fabrics; (ix) ASTM D3936-80...-81—Standard Methods for Rubber Products—Chemical Analysis; (xi) ASTM D418-82—Standard Methods of...

  4. Staging in Patients with Small-Cell Lung Carcinoma; PET-CT versus Standard Staging Procedures

    Directory of Open Access Journals (Sweden)

    Burcu Yalçın

    2016-12-01

    Full Text Available Objective: The most important factor for accurate treatment of patients with small cell lung carcinoma (SCLC is accuracy of the initial staging. The aim of this study was to determine how often patients, staged as local or local-advanced disease by standard staging procedures (SSPs, would be staged to have a metastatic disease based on the findings of the positron emission tomography–computed tomography (PET-CT scan. Methods: Patients with SCLC who were staged as I, II, or III disease by SSPs (according to the American Joint Committee on Cancer Staging, 7th edition formed the study population. SSPs included computed tomography of chest, abdomen, brain (or magnetic resonance imaging of brain, and bone scintigraphy. These patients were re-staged with 18F-FDG PET-CT scan. Results: Between 2013 and 2015, 27 patients were prospectively studied. Of these patients, 92.5% were male and the median age was 61. Among 27 patients, distant metastasis was detected by PET-CT in 7 (25.9% patients. Two of 7 patients were determined as stage IIIA by SSPs and 5 of 17 patients that were determined as stage IIIB by SSPs were upstaged to metastatic disease by PET-CT. All of the 7 patients had bone metastasis by PET-CT. But bone metastasis could not be detected with bone scintigraphy. Conclusion: PET-CT detected distant metastasis in one quarter of SCLC stage III patients by SSPs. Patients who staged local-advanced SCLC with CT of the chest have to be assessed by PET-CT for extracranial distant metastasis.

  5. Evaluation of the surface free energy of plant surfaces: toward standardizing the procedure.

    Science.gov (United States)

    Fernández, Victoria; Khayet, Mohamed

    2015-01-01

    Plant surfaces have been found to have a major chemical and physical heterogeneity and play a key protecting role against multiple stress factors. During the last decade, there is a raising interest in examining plant surface properties for the development of biomimetic materials. Contact angle measurement of different liquids is a common tool for characterizing synthetic materials, which is just beginning to be applied to plant surfaces. However, some studies performed with polymers and other materials showed that for the same surface, different surface free energy values may be obtained depending on the number and nature of the test liquids analyzed, materials' properties, and surface free energy calculation methods employed. For 3 rough and 3 rather smooth plant materials, we calculated their surface free energy using 2 or 3 test liquids and 3 different calculation methods. Regardless of the degree of surface roughness, the methods based on 2 test liquids often led to the under- or over-estimation of surface free energies as compared to the results derived from the 3-Liquids method. Given the major chemical and structural diversity of plant surfaces, it is concluded that 3 different liquids must be considered for characterizing materials of unknown physico-chemical properties, which may significantly differ in terms of polar and dispersive interactions. Since there are just few surface free energy data of plant surfaces with the aim of standardizing the calculation procedure and interpretation of the results among for instance, different species, organs, or phenological states, we suggest the use of 3 liquids and the mean surface tension values provided in this study.

  6. HYGIEN AND TECHNOLOGY OF SMOKED SALMON’S PRODUCTION: COMPARISON BETWEEN STANDARD HEALTLY REFERENCE OF EUROPEAN LEGISLATION AND AN EXTRACOMUNITY ONE

    Directory of Open Access Journals (Sweden)

    E.M. Mannocchi

    2013-02-01

    Full Text Available The work makes a comparison between European and Switzerland legislation through an inspection in an artisan producing smoked salmon factory. The analysis of HACCP plan, technology and microbiological characteristic of finished product, as enshrined in Switzerland law, allow to categorize the business risk level respect the European reference. The criticalities detected are: Listeria monocytogenes and Anisakis spp.. A plain was developed for improving the hygienic characteristic of the production to ensure the alignment of structure to the standards specified by the European requirements and allow to the factory send his products inside the European market.

  7. Impact resistance of materials for guards on cutting machine tools--requirements in future European safety standards.

    Science.gov (United States)

    Mewes, D; Trapp, R P

    2000-01-01

    Guards on machine tools are meant to protect operators from injuries caused by tools, workpieces, and fragments hurled out of the machine's working zone. This article presents the impact resistance requirements, which guards according to European safety standards for machine tools must satisfy. Based upon these standards the impact resistance of different guard materials was determined using cylindrical steel projectiles. Polycarbonate proves to be a suitable material for vision panels because of its high energy absorption capacity. The impact resistance of 8-mm thick polycarbonate is roughly equal to that of a 3-mm thick steel sheet Fe P01. The limited ageing stability, however, makes it necessary to protect polycarbonate against cooling lubricants by means of additional panes on both sides.

  8. Influence of measurement uncertainty on classification of thermal environment in buildings according to European Standard EN 15251

    DEFF Research Database (Denmark)

    Kolarik, Jakub; Olesen, Bjarne W.

    2015-01-01

    European Standard EN 15 251 in its current version does not provide any guidance on how to handle uncertainty of long term measurements of indoor environmental parameters used for classification of buildings. The objective of the study was to analyse the uncertainty for field measurements...... measurements of operative temperature at two measuring points (south/south-west and north/northeast orientation). Results of the present study suggest that measurement uncertainty needs to be considered during assessment of thermal environment in existing buildings. When expanded standard uncertainty was taken...... into account in categorization of thermal environment according to EN 15251, the difference in prevalence of exceeded category limits were up to 17.3%, 8.3% and 2% of occupied hours for category I, II and III respectively....

  9. The Adoption of European Standards in the Sphere of Economic Law and (Anticipated Cultural Change in Serbia

    Directory of Open Access Journals (Sweden)

    Marko Milenković

    2016-02-01

    Full Text Available Serbian society has undergone significant changes over the last ten years. The transformation of the legal system has taken place mostly through the process of European integrations and harmonization of legislation with the EU legal order. The primary focus of the paper is on the study of (anticiapted cultural change which is brought about by changes in economic law. By studying changing attitudes to business operation, the paper seeks to answer the questions of whether we can learn something about cultural change by analyzing economic law and whether we are witnessing the transformation of Serbian citizens into "European citizens", consumers, businessmen, farmers, bureaucrats or politicians. Some of these changes are already in evidence, and it can be said that considerable progress has already been made. Nevertheless, in most areas reforms have yet to be enacted, and therefore this transformation along with its outcome and results can only be anticipated. Following an overview of the Stabilization and Association Process, the signing of the Stabilization and Association Agreement (SAA, and the process of harmonization of legislation and monitored reforms, the paper goes on to analyze whether and to what extent the following have taken place: 1 the opening up of the Serbian economy to foreign competition (primarily European, 2 the implementation of reforms and the introduction of competition rights and government subsidy control, 3 changes in rural Serbia as part of the process of preparation for accession to the EU. It can be concluded that European integrations and the adoption of a series of different standards represent an instrumental framework for significant cultural change in Serbian society. The change will be fundamental and will take long to bring about. For this reason it can only be partially anticipated what its effects will be and whether and to what extent changes will be accopmlished in each of the areas mentioned.

  10. ABOUT THE FINANCIAL REPORTING ON THE CAPITAL MARKETS IN THE EUROPEAN UNION: REQUIREMENTS OF USING THE IFRS AND THE EQUIVALENCE OF THIRD COUNTRY ACCOUNTING STANDARDS

    Directory of Open Access Journals (Sweden)

    Aristita Rotila

    2013-12-01

    Full Text Available The need to build a single European market and to ensure the competitiveness of the community capital markets led to the involvement of European Union in the convergence process taking place on a global level in the realm of financial reporting. This paper is a study on financial reporting for the capital markets in the European Union by analyzing the accounting standards that need to be applied. Specifically, this paper highlights a number of issues concerning: the adoption of IAS / IFRS in the European Union and their compulsory aspect in preparing the consolidated financial statements for the companies listed on a regulated market; the requirement’s extension of using the IFRSs adopted in the European Union to the issuers of certain third countries involving a public offer of securities in European Union or performing transactions with securities on a community regulated market; the establish of a mechanism for the determination of equivalence of certain third country accounting standards with IFRSs in force at European level and, consequently, the possibility of using by some third country issuers, in preparing the consolidated financial statements submitted to the European markets, recognized national standards as equivalent to adopted IFRS.

  11. Conscientious objection to sexual and reproductive health services: international human rights standards and European law and practice.

    Science.gov (United States)

    Zampas, Christina; Andión-Ibañez, Ximena

    2012-06-01

    The practice of conscientious objection often arises in the area of individuals refusing to fulfil compulsory military service requirements and is based on the right to freedom of thought, conscience and religion as protected by national, international and regional human rights law. The practice of conscientious objection also arises in the field of health care, when individual health care providers or institutions refuse to provide certain health services based on religious, moral or philosophical objections. The use of conscientious objection by health care providers to reproductive health care services, including abortion, contraceptive prescriptions, and prenatal tests, among other services is a growing phenomena throughout Europe. However, despite recent progress from the European Court of Human Rights on this issue (RR v. Poland, 2011), countries and international and regional bodies generally have failed to comprehensively and effectively regulate this practice, denying many women reproductive health care services they are legally entitled to receive. The Italian Ministry of Health reported that in 2008 nearly 70% of gynaecologists in Italy refuse to perform abortions on moral grounds. It found that between 2003 and 2007 the number of gynaecologists invoking conscientious objection in their refusal to perform an abortion rose from 58.7 percent to 69.2 percent. Italy is not alone in Europe, for example, the practice is prevalent in Poland, Slovakia, and is growing in the United Kingdom. This article outlines the international and regional human rights obligations and medical standards on this issue, and highlights some of the main gaps in these standards. It illustrates how European countries regulate or fail to regulate conscientious objection and how these regulations are working in practice, including examples of jurisprudence from national level courts and cases before the European Court of Human Rights. Finally, the article will provide recommendations

  12. Basel III Global Liquidity Standards: Critical Discussion and Impact onto the European Banking Sector

    Directory of Open Access Journals (Sweden)

    Veronika Bučková

    2011-09-01

    Full Text Available Together with the Basel III regulatory equity rules, two liquidity ratios have been published. Resulting from the illiquidity of some banks during the financial crisis in 2008, these ratios shall help to prevent further crisis in the European banking sector. But do they really fulfill their aim? This article presents the new liquidity ratios, the actual liquidity situation in banks and describes the consequences for banks at a simplified example. It has to be stated that implementing more detailed liquidity frameworks into the banking supervision process is necessary. The financial crisis in 2008 showed that several banks did not have adequate liquidity risk models and processes to prevent illiquidity. But the LCR and the NSFR seem to be wrong methods. Both ratios will increase. The implementation of both ratios has to be done very carefully in order to prevent this.

  13. A Guide for Developing Standard Operating Job Procedures for the Sludge Conditioning & Dewatering Process Wastewater Treatment Facility. SOJP No. 11.

    Science.gov (United States)

    Schwing, Carl M.

    This guide describes standard operating job procedures for the sludge conditioning and dewatering process of wastewater treatment facilities. In this process, sludge is treated with chemicals to make the sludge coagulate and give up its water more easily. The treated sludge is then dewatered using a vacuum filter. The guide gives step-by-step…

  14. A Guide for Developing Standard Operating Job Procedures for the Primary Sedimentation Process Wastewater Treatment Facility. SOJP No. 4.

    Science.gov (United States)

    Charles County Community Coll., La Plata, MD.

    This guide describes standard operating job procedures for the primary sedimentation process of wastewater treatment plants. The primary sedimentation process involves removing settleable and suspended solids, in part, from wastewater by gravitational forces, and scum and other floatable solids from wastewater by mechanical means. Step-by-step…

  15. A Guide for Developing Standard Operating Job Procedures for the Screening & Grinding Process Wastewater Treatment Facility. SOJP No. 1.

    Science.gov (United States)

    Deal, Gerald A.; Montgomery, James A.

    This guide describes standard operating job procedures for the screening and grinding process of wastewater treatment facilities. The objective of this process is the removal of coarse materials from the raw waste stream for the protection of subsequent equipment and processes. The guide gives step-by-step instructions for safety inspection,…

  16. A Guide for Developing Standard Operating Job Procedures for the Sludge Thickening Process Wastewater Treatment Facility. SOJP No. 9.

    Science.gov (United States)

    Schwing, Carl M.

    This guide describes standard operating job procedures for the screening and grinding process of wastewater treatment facilities. The objective of this process is the removal of coarse materials from the raw waste stream for the protection of subsequent equipment and processes. The guide gives step-by-step instructions for safety inspection,…

  17. A Guide for Developing Standard Operating Job Procedures for the Tertiary Multimedia Filtration Process Wastewater Treatment Facility. SOJP No. 7.

    Science.gov (United States)

    Petrasek, Al, Jr.

    This guide describes the standard operating job procedures for the tertiary multimedia filtration process of wastewater treatment plants. The major objective of the filtration process is the removal of suspended solids from the reclaimed wastewater. The guide gives step-by-step instructions for pre-start up, start-up, continuous operation, and…

  18. A Guide for Developing Standard Operating Job Procedures for the Digestion Process Wastewater Treatment Facility. SOJP No. 10.

    Science.gov (United States)

    Schwing, Carl M.

    This guide describes standard operating job procedures for the digestion process of wastewater treatment facilities. This process is for reducing the volume of sludge to be treated in subsequent units and to reduce the volatile content of sludge. The guide gives step-by-step instructions for pre-startup, startup, continuous operating, shutdown,…

  19. 78 FR 4060 - Manufactured Home Construction and Safety Standards, Test Procedures for Roof Trusses

    Science.gov (United States)

    2013-01-18

    ..., such as metal connector plates or wood gussets or their equivalents, uplift testing in Wind Zone I is.... SUMMARY: This final rule amends the roof truss testing procedures in the Federal Manufactured Home... testing procedures in 2003. In response to public comments, HUD returned the proposal to MHCC for further...

  20. Beyond the Standard Model Lectures for the 2016 European School of High-Energy Physics

    CERN Document Server

    Allanach, B C

    2017-01-01

    We cover some current topics in Beyond the Standard Model phenomenology, with an emphasis on collider (particularly Large Hadron Collider) phenomenology. We begin with a review of the Standard Model and some unresolved mysteries that it leaves. Then, we shall heuristically introduce supersymmetry, grand unified theories and extra dimensions as paradigms for expanding the Standard Model. The collider phenomenology of such models is too rich and complex to review, but we give some key examples of how the new states associated with the models might be inferred in Large Hadron Collider events. Before concluding, we finish with a brief description of a quantum field theory approximation that can be used in some cases to reduce model dependence: effective field theory.

  1. Feasibility of dietary assessment methods, other tools and procedures for a pan-European food consumption survey among infants, toddlers and children

    DEFF Research Database (Denmark)

    Ocké, Marga; Brants, Henny; Dofkova, Marcela

    2014-01-01

    more challenging by the interviewers. Conclusions Both dietary assessment methods with related tools and administration protocols were evaluated as feasible. The administration protocol with two 1-day food diaries with completion interviews offers more advantages for the future pan-European survey......Purpose To test the feasibility of tools and procedures for a pan-European food consumption survey among children 0-10 years and to recommend one of two tested dietary assessment methods. Methods Two pilot studies including 378 children were conducted in Belgium and the Czech Republic in the Pilot...

  2. Calibration of brachytherapy sources. Guidelines on standardized procedures for the calibration of brachytherapy sources at Secondary Standard Dosimetry Laboratories (SSDLs) and hospitals

    International Nuclear Information System (INIS)

    1999-04-01

    Today, irradiation by brachytherapy is considered an essential part of the treatment for almost all the sites of cancer. With the improved localization techniques and treatment planning systems, it is now possible to have precise and reproducible dose delivery. However, the desired clinical results can only be achieved with a good clinical and dosimetric practice, i.e. with the implementation of a comprehensive quality assurance (QA) programme which includes detailed quality control procedures. As summarized in the present report, accidents in brachytherapy treatments have been caused due to the lack of traceable calibration of the sources, due to the incorrect use of quantities and units, or errors made in the dose calculation procedure. The International Basic Safety Standards for Protection against Ionizing Radiation and for the Safety of Radiation Sources has established a requirement on the calibration of sources used for medical exposure. For sources used in brachytherapy treatments, a calibration traceable to a standards dosimetry laboratory is required. The present report deals with the calibration of brachytherapy sources and related quality control (QC) measurements, QC of ionization chambers and safety aspects related to the calibration procedures. It does not include safety aspects related to the clinical use of brachytherapy sources, which have been addressed in a recent IAEA publication, IAEA-TECDOC-1040, 'Design and Implementation of a Radiotherapy Programme: Clinical, Medical Physics, Radiation Protection and Safety Aspects'. The procedures recommended in this report yield traceability to internationally accepted standards. It must be realized, however, that a comprehensive QA programme for brachytherapy cannot rest on source calibration alone, but must ensure QC of all the equipment and techniques that are used for the dose delivery to the patient. The present publication incorporates the reports of several consultants meetings in the field of

  3. Health care costs attributable to overweight calculated in a standardized way for three European countries

    NARCIS (Netherlands)

    Lette, M.; Bemelmans, W.J.; Breda, J.; Slobbe, L.C.; Dias, J.; Boshuizen, H.C.

    2016-01-01

    This article presents a tool to calculate health care costs attributable to overweight in a comparable and standardized way. The purpose is to describe the methodological principles of the tool and to put it into use by calculating and comparing the costs attributable to overweight for The

  4. Evolution of European GM-free standards: Reasoning of consumers and strategic adoption by companies

    NARCIS (Netherlands)

    Venus, T.J.; Wesseler, J.H.H.

    2015-01-01

    In this article, we discuss reasoning of consumers and strategic adoption behavior of producers and retailers with respect to genetically modified-free (GM-free) quality standards in Europe. We argue that there are three major reasons why a mandatory GM labeling scheme differs from a voluntary

  5. [Orthotopic cardiac transplantation with caval anastomosis: a comparative randomized study with standard procedure in 81 cases].

    Science.gov (United States)

    Deleuze, P; Benvenuti, C; Mazzucotelli, J P; Perdrix, C; Le Besnerais, P; Mourtada, A; Hillion, M L; Patrat, J F; Loisance, D Y

    1996-01-01

    Complete resection of the right atrium with conservation of a strip of left atrium around the 4 pulmonary veins followed by direct anastomosis on the vena cava has recently been proposed as an alternative to the standard orthotopic cardiac transplantation described by Shumway and Lower. In order to determine whether this "anatomical" transplantation should now be considered to be the procedure of choice, a prospective randomised study was undertaken in 1991 including 78 patients undergoing 81 cardiac transplantations by one of the two techniques: gr. I: classical transplantation (n = 40), gr. II: "anatomical" transplantation (n = 41). The groups were comparable in age, sex, weight, nature of the underlying cardiac disease and clinical status at the time of transplantation. Similarly, the parameters of the donors were comparable with respect to age, sex, weight and dosage of inotropic drugs at the time of explantation. All patients came of cardiopulmonary bypass with comparable ischaemia time of the graft (gr. I: 136 +/- 46 min; gr. II: 138 +/- 51 min). Immediate return to sinus rhythm occurred in 20 cases in gr. I and 36 cases in gr. II. Atrial arrhythmia persisted in 5 cases in gr. I but in no cases of gr. II. These differences were very significant (p < 0.001). There were 13 early deaths in gr. I and 8 in gr. II. Doppler echocardiography was performed two to three months after transplantation. The right atrial surface was significantly decreased in gr. II (18 +/- 4.7 cm2) compared with gr. I (24 +/- 7 cm2): the same difference was observed for the left atrium (gr. I: 24 +/- 4.5 cm2; gr. II: 20 +/- 5 cm2), p = 0.001. Tricuspid regurgitation was observed in 82% of patients in gr. I compared with 57% in gr. II (p < 0.005). Exercise stress tests during the same period showed no difference in peak oxygen consumption between the groups. Holter ECG monitoring led to permanent pacing in 2 patients of gr. I (5%). The technical simplicity and reduction of postoperative

  6. SURF: Taking Sustainable Remediation from Concept to Standard Operating Procedure (Invited)

    Science.gov (United States)

    Smith, L. M.; Wice, R. B.; Torrens, J.

    2013-12-01

    Over the last decade, many sectors of industrialized society have been rethinking behavior and re-engineering practices to reduce consumption of energy and natural resources. During this time, green and sustainable remediation (GSR) has evolved from conceptual discussions to standard operating procedure for many environmental remediation practitioners. Government agencies and private sector entities have incorporated GSR metrics into their performance criteria and contracting documents. One of the early think tanks for the development of GSR was the Sustainable Remediation Forum (SURF). SURF brings together representatives of government, industry, consultancy, and academia to parse the means and ends of incorporating societal and economic considerations into environmental cleanup projects. Faced with decades-old treatment programs with high energy outputs and no endpoints in sight, a small group of individuals published the institutional knowledge gathered in two years of ad hoc meetings into a 2009 White Paper on sustainable remediation drivers, practices, objectives, and case studies. Since then, SURF has expanded on those introductory topics, publishing its Framework for Integrating Sustainability into Remediation Projects, Guidance for Performing Footprint Analyses and Life-Cycle Assessments for the Remediation Industry, a compendium of metrics, and a call to improve the integration of land remediation and reuse. SURF's research and members have also been instrumental in the development of additional guidance through ASTM International and the Interstate Technology and Regulatory Council. SURF's current efforts focus on water reuse, the international perspective on GSR (continuing the conversations that were the basis of SURF's December 2012 meeting at the National Academy of Sciences in Washington, DC), and ways to capture and evaluate the societal benefits of site remediation. SURF also promotes and supports student chapters at universities across the US

  7. Interim radiological safety standards and evaluation procedures for subseabed high-level waste disposal

    Energy Technology Data Exchange (ETDEWEB)

    Klett, R.D.

    1997-06-01

    The Seabed Disposal Project (SDP) was evaluating the technical feasibility of high-level nuclear waste disposal in deep ocean sediments. Working standards were needed for risk assessments, evaluation of alternative designs, sensitivity studies, and conceptual design guidelines. This report completes a three part program to develop radiological standards for the feasibility phase of the SDP. The characteristics of subseabed disposal and how they affect the selection of standards are discussed. General radiological protection standards are reviewed, along with some new methods, and a systematic approach to developing standards is presented. The selected interim radiological standards for the SDP and the reasons for their selection are given. These standards have no legal or regulatory status and will be replaced or modified by regulatory agencies if subseabed disposal is implemented. 56 refs., 29 figs., 15 tabs.

  8. Interim radiological safety standards and evaluation procedures for subseabed high-level waste disposal

    International Nuclear Information System (INIS)

    Klett, R.D.

    1997-06-01

    The Seabed Disposal Project (SDP) was evaluating the technical feasibility of high-level nuclear waste disposal in deep ocean sediments. Working standards were needed for risk assessments, evaluation of alternative designs, sensitivity studies, and conceptual design guidelines. This report completes a three part program to develop radiological standards for the feasibility phase of the SDP. The characteristics of subseabed disposal and how they affect the selection of standards are discussed. General radiological protection standards are reviewed, along with some new methods, and a systematic approach to developing standards is presented. The selected interim radiological standards for the SDP and the reasons for their selection are given. These standards have no legal or regulatory status and will be replaced or modified by regulatory agencies if subseabed disposal is implemented. 56 refs., 29 figs., 15 tabs

  9. Evaluation of the ISO Standard 11063 DNA Extraction Procedure for Assessing Soil Microbial Abundance and Community Structure

    Science.gov (United States)

    Griffiths, Robert; Dequiedt, Samuel; Lelievre, Mélanie; Regnier, Tiffanie; Nowak, Virginie; Bailey, Mark; Lemanceau, Philippe; Bispo, Antonio; Chabbi, Abad; Maron, Pierre-Alain; Mougel, Christophe; Ranjard, Lionel

    2012-01-01

    Soil DNA extraction has become a critical step in describing microbial biodiversity. Historically, ascertaining overarching microbial ecological theories has been hindered as independent studies have used numerous custom and commercial DNA extraction procedures. For that reason, a standardized soil DNA extraction method (ISO-11063) was previously published. However, although this ISO method is suited for molecular tools such as quantitative PCR and community fingerprinting techniques, it has only been optimized for examining soil bacteria. Therefore, the aim of this study was to assess an appropriate soil DNA extraction procedure for examining bacterial, archaeal and fungal diversity in soils of contrasting land-use and physico-chemical properties. Three different procedures were tested: the ISO-11063 standard; a custom procedure (GnS-GII); and a modified ISO procedure (ISOm) which includes a different mechanical lysis step (a FastPrep ®-24 lysis step instead of the recommended bead-beating). The efficacy of each method was first assessed by estimating microbial biomass through total DNA quantification. Then, the abundances and community structure of bacteria, archaea and fungi were determined using real-time PCR and terminal restriction fragment length polymorphism approaches. Results showed that DNA yield was improved with the GnS-GII and ISOm procedures, and fungal community patterns were found to be strongly dependent on the extraction method. The main methodological factor responsible for differences between extraction procedure efficiencies was found to be the soil homogenization step. For integrative studies which aim to examine bacteria, archaea and fungi simultaneously, the ISOm procedure results in higher DNA recovery and better represents microbial communities. PMID:22984486

  10. Evaluation of the ISO standard 11063 DNA extraction procedure for assessing soil microbial abundance and community structure.

    Directory of Open Access Journals (Sweden)

    Pierre Plassart

    Full Text Available Soil DNA extraction has become a critical step in describing microbial biodiversity. Historically, ascertaining overarching microbial ecological theories has been hindered as independent studies have used numerous custom and commercial DNA extraction procedures. For that reason, a standardized soil DNA extraction method (ISO-11063 was previously published. However, although this ISO method is suited for molecular tools such as quantitative PCR and community fingerprinting techniques, it has only been optimized for examining soil bacteria. Therefore, the aim of this study was to assess an appropriate soil DNA extraction procedure for examining bacterial, archaeal and fungal diversity in soils of contrasting land-use and physico-chemical properties. Three different procedures were tested: the ISO-11063 standard; a custom procedure (GnS-GII; and a modified ISO procedure (ISOm which includes a different mechanical lysis step (a FastPrep ®-24 lysis step instead of the recommended bead-beating. The efficacy of each method was first assessed by estimating microbial biomass through total DNA quantification. Then, the abundances and community structure of bacteria, archaea and fungi were determined using real-time PCR and terminal restriction fragment length polymorphism approaches. Results showed that DNA yield was improved with the GnS-GII and ISOm procedures, and fungal community patterns were found to be strongly dependent on the extraction method. The main methodological factor responsible for differences between extraction procedure efficiencies was found to be the soil homogenization step. For integrative studies which aim to examine bacteria, archaea and fungi simultaneously, the ISOm procedure results in higher DNA recovery and better represents microbial communities.

  11. Health care costs attributable to overweight calculated in a standardized way for three European countries

    OpenAIRE

    Lette, M.; Bemelmans, W. J. E.; Breda, J.; Slobbe, L. C. J.; Dias, J.; Boshuizen, H. C.

    2014-01-01

    This article presents a tool to calculate health care costs attributable to overweight in a comparable and standardized way. The purpose is to describe the methodological principles of the tool and to put it into use by calculating and comparing the costs attributable to overweight for The Netherlands, Germany and Czech Republic. The tool uses a top-down and prevalence-based approach, consisting of five steps. Step one identifies overweight-related diseases and age- and gender-specific relati...

  12. Standard Operating Procedures for Preparing and Handling Sterile Male Tsetse flies for Release

    International Nuclear Information System (INIS)

    Argiles-Herrero, Rafa; Leak, Stephen G.A.

    2016-01-01

    The purpose of this SOP is to describe the procedures involved in preparing tsetse flies reared in a breeding facility for release in the field for the sterile insect technique (SIT) as a component of Area-Wide Insect pest Management (AW-IPM). Following the procedures which are outlined will help to ensure that the released sterile male tsetse flies are of optimal quality.

  13. Standard operating procedure for combustion of 14C - samples with OX-500 biological material oxidizer

    International Nuclear Information System (INIS)

    Nashriyah Mat.

    1995-01-01

    This procedure is for the purpose of safe operation of OX-500 biological material oxidizer. For ease of operation, the operation flow chart (including testing the system and sample combustion) and end of day maintenance flow chart were simplified. The front view, diagrams and switches are duly copied from operating manual. Steps on sample preparation are also included for biotic and a biotic samples. This operating procedure is subjected to future reviews

  14. Influence of D-net (EUROPEAN GSM-standard) cellular telephones on implanted pacemakers in children.

    Science.gov (United States)

    Elshershari, Huda; Celiker, Alpay; Ozer, Sema; Ozme, Sencan

    2002-09-01

    This study was designed to evaluate possible interactions between digital cellular telephones and implanted pacemakers in children. The study comprised 95 patients (53 males and 42 females) with a mean age of 11.5 +/- 4.6 years (range 1-22 years). The average time from pacemaker implantation was 2.5 years (range 1 month-12 years). Fourteen (15%) devices were dual chamber and the remaining were single chamber pacemakers. The following companies manufactured the pacemakers tested: Medtronic (n = 42), Telectronics (n = 9), Vitatron (n = 16), Pacesetter (n = 19), CPI (n = 8), and Biotronik (n = 1). All the patients were tested in the supine position during continuous ECG monitoring. After completion of the routine pacemaker check, the effects of the European Global system for mobile communication (GSM) was tested using two cellular telephone models (Ericsson GA 628 and Siemens S 25, 2-W power). For this purpose, atrial and ventricular sensitivity settings were programmed to the most sensitive values, and the tests were carried out in the unipolar and bipolar sensing modes. The evaluation was performed during ringing, switching on/off, and conversation phase with the cellular telephone positioned over the pulse generator and around the pacemaker pocket. A malfunction of the pacemaker was not observed in any patient. Only 1 (1%) of 95 patients showed a brief oversensing problem during calls with the cellular telephone. In this case, an AAIR pacemaker was implanted transvenously in a subcutaneous pocket and the sensing defect occurred only with the unipolar sensing mode and was not reproducible. Once the source of interference was removed, no sensing defect was detected and the patient remained asymptomatic. No symptoms were experienced in this study. The authors believe that pacemaker dependent patients with nonprotected pulse generators manufactured at the beginning of 1990s may be tested by their physicians for possible interferences before they use a digital cellular

  15. Non-Standard Workers: The South African Context, International Law and Regulation by The European Union

    Directory of Open Access Journals (Sweden)

    ES Fourie

    2008-12-01

    Full Text Available The current labour market has many forms of employment relations that differ from full-time employment. "Atypical," "non-standard," or even "marginal" are terms used to describe these new workers and include, amongst others, part-time work, contract work, self-employment, temporary, fixed-term, seasonal, casual, piece-rate work, employees supplied by employment agencies, home workers and those employed in the informal economy. These workers are often paid for results rather than time. Their vulnerability is linked in many instances to the absence of an employment relationship or the existence of a flimsy one. Most of these workers are unskilled or work in sectors with limited trade union organisation and limited coverage by collective bargaining, leaving them vulnerable to exploitation. They should, in theory, have the protection of current South African labour legislation, but in practice the unusual circumstances of their employment render the enforcement of their rights problematic. The majority of non-standard workers in South Africa are those previously disadvantaged by the apartheid regime, compromising women and unskilled black workers. The exclusion of these workers from labour legislation can be seen as discrimination, which is prohibited by almost all labour legislation in South Africa. This contribution illustrates how the concept of indirect discrimination can be an important tool used to provide labour protection to these workers. The purpose of this article is to explore the scope of the extension of labour rights to non-standard workers in the context of South African labour laws and the international framework.

  16. Specialized food composition dataset for vitamin D content in foods based on European standards: Application to dietary intake assessment.

    Science.gov (United States)

    Milešević, Jelena; Samaniego, Lourdes; Kiely, Mairead; Glibetić, Maria; Roe, Mark; Finglas, Paul

    2018-02-01

    A review of national nutrition surveys from 2000 to date, demonstrated high prevalence of vitamin D intakes below the EFSA Adequate Intake (AI) (d vitamin D) in adults across Europe. Dietary assessment and modelling are required to monitor efficacy and safety of ongoing strategic vitamin D fortification. To support these studies, a specialized vitamin D food composition dataset, based on EuroFIR standards, was compiled. The FoodEXplorer™ tool was used to retrieve well documented analytical data for vitamin D and arrange the data into two datasets - European (8 European countries, 981 data values) and US (1836 data values). Data were classified, using the LanguaL™, FoodEX2 and ODIN classification systems and ranked according to quality criteria. Significant differences in the content, quality of data values, missing data on vitamin D 2 and 25(OH)D 3 and documentation of analytical methods were observed. The dataset is available through the EuroFIR platform. Copyright © 2017 Elsevier Ltd. All rights reserved.

  17. New tendencies in isotopic analysis of pesticide residues from wines by mass spectrometry in concordance with the European standards

    International Nuclear Information System (INIS)

    Costinel, Diana; Lazar, Roxana Elena; Vremera, Raluca; Irimescu, Rodica; Saros-Rogobete, Gili

    2006-01-01

    Multi-isotope analysis, the determination of isotope ratios by mass spectrometry or magnetic resonance spectroscopy, becomes increasingly used in the food industry and by national food control laboratories as a method of authenticating both raw materials and finished products. These highly sophisticated techniques are capable of determining the botanical and geographical origin of a wide variety of foodstuffs, thus providing a means of detecting product adulteration and controlling mislabelling practices which are virtually impossible to circumvent. The European Union has officially adopted the used of isotope analysis as a means of controlling sugar addition in wines. Its successful implementation in the wine-producing Member States has considerably reduced the financial losses which the Community had incurred due to over - capitalisation. Coupling mass spectrometer with gas chromatograph is used for quantitative and qualitative analysis of traces of pesticides from food. The presence of pesticides in foods is harmful for the nervous system, the cardiovascular apparatus and decreases the immunity of human body. In addition, ensuring the foods quality and safety is a requirement, which must be fulfilled for the integration in EU. The subject of this paper is the presentation of the tests results of the isotopic analysis for pesticide residues in wines, in concordance with European Standard. (authors)

  18. A Meta-Analytic Assessment of Empirical Differences in Standard Setting Procedures.

    Science.gov (United States)

    Bontempo, Brian D.; Marks, Casimer M.; Karabatsos, George

    Using meta-analysis, this research takes a look at studies included in a meta-analysis by R. Jaeger (1989) that compared the cut score set by one standard setting method with that set by another. This meta-analysis looks beyond Jaeger's studies to select 10 from the research literature. Each compared at least two types of standard setting method.…

  19. Core Standards of the EUBIROD Project. Defining a European Diabetes Data Dictionary for Clinical Audit and Healthcare Delivery.

    Science.gov (United States)

    Cunningham, S G; Carinci, F; Brillante, M; Leese, G P; McAlpine, R R; Azzopardi, J; Beck, P; Bratina, N; Bocquet, V; Doggen, K; Jarosz-Chobot, P K; Jecht, M; Lindblad, U; Moulton, T; Metelko, Ž; Nagy, A; Olympios, G; Pruna, S; Skeie, S; Storms, F; Di Iorio, C T; Massi Benedetti, M

    2016-01-01

    A set of core diabetes indicators were identified in a clinical review of current evidence for the EUBIROD project. In order to allow accurate comparisons of diabetes indicators, a standardised currency for data storage and aggregation was required. We aimed to define a robust European data dictionary with appropriate clinical definitions that can be used to analyse diabetes outcomes and provide the foundation for data collection from existing electronic health records for diabetes. Existing clinical datasets used by 15 partner institutions across Europe were collated and common data items analysed for consistency in terms of recording, data definition and units of measurement. Where necessary, data mappings and algorithms were specified in order to allow partners to meet the standard definitions. A series of descriptive elements were created to document metadata for each data item, including recording, consistency, completeness and quality. While datasets varied in terms of consistency, it was possible to create a common standard that could be used by all. The minimum dataset defined 53 data items that were classified according to their feasibility and validity. Mappings and standardised definitions were used to create an electronic directory for diabetes care, providing the foundation for the EUBIROD data analysis repository, also used to implement the diabetes registry and model of care for Cyprus. The development of data dictionaries and standards can be used to improve the quality and comparability of health information. A data dictionary has been developed to be compatible with other existing data sources for diabetes, within and beyond Europe.

  20. Malpractice claims and unintentional outcome of tonsil surgery and other standard procedures in otorhinolaryngology

    Science.gov (United States)

    Windfuhr, Jochen P.

    2015-01-01

    of malpractice after LN (16; 57%), TE (10; 37%), SP (8; 57%) and AE (2; 100%). There were 16 cases of PTH amongst 27 trials after TE resulting either in death (5) or apallic syndrome (5). Bleeding complications had occurred on the day of surgery in only 2 patients. 16 trials were based on malpractice claims following SP encompassing lack of informed consent (6), anosmia (4), septal perforation (2), frontobasal injury (2) and dry nose (2). Trials after LN procedures were associated exclusively with a lesion of the spinal accessory nerve (28), including lack of informed consent in 19 cases. 49 cases (69%) were decided for the defendant, 22 (31%) were decided for the plaintiff with monetary compensation in 7 of 29 AE/TE-trials, 9 of 28 LN-trials and 6 of 14 SP-trials. Lack of informed consent was not registered for AE/TE but LN (11) and SP (2). Conclusion: Complicated cases following TE, TT, ATE, SP and LN are not systematically collected in Germany. It can be assumed, that not every complicated case is published in the medical literature or law journals and therefore not obtainable for scientific research. Alleged medical malpracice is proven for less than 6% before trial stage. Approximately half of all cases result in a plaintiff verdict or settlement at court. Proper documentation of a thourough counselling, examination, indication, informed consent and follow-up assists the surgeon in litigation. An adequate complication management of PTH is essential, including instructions for the patients/parents, instructions for the medical staff and readily available surgical instruments. Successful outcome of life-threatening PTH is widely based on a proper airway management in an interdisciplinary approach. Electrosurgical tonsillectomy techniques were repeatedly labeled as a risk factor for bleeding complications following TE. Institutions should analyse the individual PTH rate on a yearly basis. Contradictory expert opinions and verdicts of the courts concerning spinal

  1. TESTING OF CONCRETE PAVING BLOCKS THE BS EN 1338:2003 BRITISH AND EUROPEAN STANDARD CODE

    Directory of Open Access Journals (Sweden)

    Purwanto Purwanto

    2012-02-01

    Full Text Available Concrete paving blocks are the choice for road and urban road’s surfacing. Besides their ease inapplication, they also provide design freedom by coloring off the material.Of major importance is their compression strength. The Indonesian SNI categorizes strength to theirpurposes i.e., for parking areas, pedestrian walking areas and heavy industrial estates.According to the SNI 03 – 0691 -1989 and British Standard BS 6717:1986 the strength of a paving blockis determined by the maximum carrying capacity under distributed load. The blocks are placed under acompression apparatus, and the compression strength at failure is recorded.As being observed in the field paving block’s failure pattern differs as to the failure under distributedloading. The paving’s failure mode is distinguished by a bending failure plain at the smallest crosssection.The BS EN 1338 code proposes a different approach. This paper will discuss the methods being used inthe BS EN 1338 code, and evaluates the effectiveness of Indonesian standards to date.

  2. EVOLUTION OF EUROPEAN GM-FREE STANDARDS: REASONING OF CONSUMERS AND STRATEGIC ADOPTION BY COMPANIES

    Directory of Open Access Journals (Sweden)

    Thomas J. VENUS

    2015-11-01

    Full Text Available In this article, we discuss reasoning of consumers and strategic adoption behavior of producers and retailers with respect to genetically modified-free (GM-free quality standards in Europe. We argue that there are three major reasons why a mandatory GM labeling scheme differs from a voluntary process-based GM-free labeling scheme regarding the effect on consumer demand: (1 while both mandatory and voluntary labels signal that products containing, or produced with genetically modified organisms (GMOs are of lower quality, experiments show that the signaling effect is stronger in the case of mandatory labels; (2 some consumers care more about the effects of consuming GMOs directly (i.e., labeled GMO compared to consuming only products derived from GMOs (i.e., non-labeled GM-free; and (3 mandatory labeling shifts some of the labeling burden to the GM producer making the GM product relatively more expensive compared to the case of voluntary GM-free labeling. We discuss reasons why producers or retailers set or implement a voluntary GM-free production standard. To illustrate how the firm adoption theory can be extended, we use a real option game framework in a duopolistic setting and show that it can be beneficial to offer a GM-free product without labeling it. We show that this can be the case if investing without labeling works as a pre-investment or option to extend to reduce the investment cost of implementing a label in the case of an increase in demand. Finally, we provide a list of important events that have affected the evolution of the GM-free market in Europe.

  3. Extended device profiles and testing procedures for the approval process of integrated medical devices using the IEEE 11073 communication standard.

    Science.gov (United States)

    Janß, Armin; Thorn, Johannes; Schmitz, Malte; Mildner, Alexander; Dell'Anna-Pudlik, Jasmin; Leucker, Martin; Radermacher, Klaus

    2018-02-23

    Nowadays, only closed and proprietary integrated operating room systems (IORS) from big manufacturers are available on the market. Hence, the interconnection of components from third-party vendors is only possible with increased time and costs. In the context of the German Federal Ministry of Education and Research (BMBF)-funded project OR.NET (2012-2016), the open integration of medical devices from different manufacturers was addressed. An integrated operating theater based on the open communication standard IEEE 11073 shall give clinical operators the opportunity to choose medical devices independently of the manufacturer. This approach would be advantageous especially for hospital operators and small- and medium-sized enterprises (SME) of medical devices. Actual standards and concepts regarding technical feasibility and the approval process do not cope with the requirements for a modular integration of medical devices in the operating room (OR), based on an open communication standard. Therefore, innovative approval strategies and corresponding certification and test procedures, which cover actual legal and normative standards, have to be developed in order to support the future risk management and the usability engineering process of open integrated medical devices in the OR. The use of standardized device and service profiles and a three-step testing procedure, including conformity, interoperability and integration tests are described in this paper and shall support the manufacturers to integrate their medical devices without disclosing the medical devices' risk analysis and related confidential expertise or proprietary information.

  4. The changes in hazard classification and product notification procedures of the new European CLP and Cosmetics Regulations.

    NARCIS (Netherlands)

    de Groot, R.; Brekelmans, P.; Herremans, J.; Meulenbelt, J.

    2010-01-01

    INTRODUCTION: The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS) is developed to harmonize the criteria for hazard communication worldwide. The European Regulation on classification, labeling, and packaging of substances and mixtures [CLP Regulation

  5. The changes in hazard classification and product notification procedures of the new European CLP and Cosmetics Regulations

    NARCIS (Netherlands)

    de Groot, Ronald; Brekelmans, Pieter; Herremans, Joke; Meulenbelt, Jan

    Introduction. The United Nations Globally Harmonized System of Classification and Labelling of Chemicals (UN-GHS) is developed to harmonize the criteria for hazard communication worldwide. The European Regulation on classification, labeling, and packaging of substances and mixtures [CLP Regulation

  6. Standardized ileal digestibility of amino acids in European soya bean and rapeseed products fed to growing pigs.

    Science.gov (United States)

    Kaewtapee, C; Mosenthin, R; Nenning, S; Wiltafsky, M; Schäffler, M; Eklund, M; Rosenfelder-Kuon, P

    2018-04-01

    This study was conducted to determine the chemical composition and standardized ileal digestibility coefficients (SID) of crude protein (CP) and amino acids (AA) of European soya bean and rapeseed products in pigs. Six soya bean and two rapeseed products were used as the sole dietary source of CP and AA, including raw (FFSB) and roasted full-fat soya beans (FFSB R oasted ), soya bean (SBC) and rapeseed cake (RSC), and rapeseed meal (RSM) from Bavaria (Germany), soya bean meal (SBM) from the Danube region (Austria; SBM A ustria ), a commercially available standard SBM (SBM S td ) and an imported genetically modified organism-free SBM (SBM GMO -free ). Eight ileal- cannulated pigs with an initial body weight of 32 ± 2 kg were allotted to a row-column design with eight diets and six periods of seven days each. Trypsin inhibitor activity (TIA) ranged from 1.8 in SBM S td to 24.5 mg/g DM in FFSB. The SID of CP and all AA in FFSB R oasted were greater than in FFSB, but lower when compared to SBC and SBM A ustria (p < .05). The SID of CP and all AA (except glutamic acid) were not different between SBC and SBM A ustria , but the SID of CP and all AA (except methionine) were greater (p < .05) in SBC than in SBM GMO -free . Furthermore, the SID of CP and most AA showed a quadratic response with decreasing TIA, and there exists a quadratic response in SID of CP and all AA with increasing lysine to CP ratio and neutral detergent insoluble nitrogen (p < .05). In conclusion, variation in chemical composition and SID of CP and AA was observed in different European soya bean and rapeseed products as influenced by differences in processing conditions. European SBC and SBM A ustria can be used as alternative to imported SBM GMO -free and SBM S td in diets for growing pigs. © 2017 Blackwell Verlag GmbH.

  7. CTEPP STANDARD OPERATING PROCEDURE FOR CONDUCTING INTERNAL FIELD AUDITS AND QUALITY CONTROL (SOP-2.25)

    Science.gov (United States)

    This SOP describes the method for conducting internal field audits and quality control procedures. Internal field audits will be conducted to ensure the collection of high quality data. Internal field audits will be conducted by Field Auditors (the Field QA Officer and the Field...

  8. Effects of Computer-Based Training on Procedural Modifications to Standard Functional Analyses

    Science.gov (United States)

    Schnell, Lauren K.; Sidener, Tina M.; DeBar, Ruth M.; Vladescu, Jason C.; Kahng, SungWoo

    2018-01-01

    Few studies have evaluated methods for training decision-making when functional analysis data are undifferentiated. The current study evaluated computer-based training to teach 20 graduate students to arrange functional analysis conditions, analyze functional analysis data, and implement procedural modifications. Participants were exposed to…

  9. 42 CFR 493.1255 - Standard: Calibration and calibration verification procedures.

    Science.gov (United States)

    2010-10-01

    ... least a minimal (or zero) value, a mid-point value, and a maximum value near the upper limit of the... the number, type, and concentration of calibration materials, as well as acceptable limits for and the... acceptable limits for calibration verification. (b) Perform and document calibration verification procedures...

  10. HUBUNGAN ANTARA GAYA KEPEMIMPINAN PATH GOAL SUPERVISOR PABRIK BAJA DENGAN TINGKAT KEPATUHAN SOP (STANDARD OPERATIONAL PROCEDURE) PEKERJA

    OpenAIRE

    Ridho, Wahyu Fahrul

    2017-01-01

    ABSTRACTEmployee ignorance on Standard Operational Procedures (SOP) is one of the main causes of workplace accidents. This study was conducted to analyze the correlation between path goal leadership implemented by Gresik steel factory supervisors and employee obedience on company SOP. This study applied quantitative approach and cross-sectional research design. The data were collected through observation and interview on 52 respondents consisting of employees working led by 4 different superv...

  11. Comparison of the efficacy of standard bariatric surgical procedures on Saudi population using the bariatric analysis and reporting outcome system

    Directory of Open Access Journals (Sweden)

    Azzam Al Kadi

    2017-03-01

    Full Text Available Objectives: To compare the efficacy of various standard bariatric surgical procedures using the Bariatric Analysis and Reporting Outcome System (BAROS. Methods: This is a prospective, descriptive analytical study conducted in 2 medical institutions in Saudi Arabia. A total of 270 patients who had different bariatric surgery during the period between March 2010 and December 2012 were included. The data was analyzed and scored against 3 outcomes, excess weight loss, cure or improvement of comorbidities, and quality of life changes. Results: All patients who had different bariatric procedures were included in our study. Seventy-nine (29.3% underwent laparoscopic Roux-en-Y gastric bypass (LRYGBP, 159 (58.9% had laparoscopic sleeve gastrectomy (LSG, and 32 (11.9% had laparoscopic adjustable gastric banding (LAGB. Complete remission of at least one comorbidity was reported in 36% of LRYGBP, 51% in LSG, and 42% in LAGB. While all other patients have improved comorbidities. The BAROS score was good or higher in 78.5% of LRYGBP, 83.6% for the LSG, and 84.4% of LAGB patients. The average excess weight loss was 67.9% in LRYGBP, 75.8% in LSG, and 81.7% LAGB patients. Conclusion: Bariatric surgery provides a substantial reduction in excess weight, improvement and cure of comorbidities, and improvement in quality of life. Standard bariatric procedures have different degrees of outcomes that can be beneficial in selecting appropriate procedure for appropriate indications and patients.

  12. Health care costs attributable to overweight calculated in a standardized way for three European countries.

    Science.gov (United States)

    Lette, M; Bemelmans, W J E; Breda, J; Slobbe, L C J; Dias, J; Boshuizen, H C

    2016-01-01

    This article presents a tool to calculate health care costs attributable to overweight in a comparable and standardized way. The purpose is to describe the methodological principles of the tool and to put it into use by calculating and comparing the costs attributable to overweight for The Netherlands, Germany and Czech Republic. The tool uses a top-down and prevalence-based approach, consisting of five steps. Step one identifies overweight-related diseases and age- and gender-specific relative risks. Included diseases are ischemic heart disease, stroke, hypertension, type 2 diabetes mellitus, colorectal cancer, postmenopausal breast cancer, endometrial cancer, kidney cancer and osteoarthritis. Step two consists of collecting data on the age- and gender-specific prevalence of these diseases. Step three uses the population-attributable prevalence to determine the part of the prevalence of these diseases that is attributable to overweight. Step four calculates the health care costs associated with these diseases. Step five calculates the costs of these diseases that are attributable to overweight. Overweight is responsible for 20-26% of the direct costs of included diseases, with sensitivity analyses varying this percentage between 15-31%. Percentage of costs attributable to obesity and preobesity is about the same. Diseases with the highest percentage of costs due to overweight are diabetes, endometrial cancer and osteoarthritis. Disease costs attributable to overweight as a percentage of total health care expenditures range from 2 to 4%. Data are consistent for all three countries, resulting in roughly a quarter of costs of included diseases being attributable to overweight.

  13. Aircrew Compliance with Standard Operating Procedures as a Component of Airline Safety.

    Science.gov (United States)

    1980-01-01

    typical operating environment, the crew activity associated with it is thought to be representative of habitual behavior. In contrast, the second...Most of the participants were assigned to a single aircrew domicle. The one captain who came from a different domicile is subjectively ranked between...initiations lies in the sweeping Command and Management Procedures. They affirm that responsibility for all operational activity resides in the

  14. A retrospective study of 2585 patients patch tested with the European standard series in Hong Kong (1995-99).

    Science.gov (United States)

    Lam, Wai Sun; Chan, Loi Yuen; Ho, Stanley Ching Kong; Chong, Lai Yin; So, Win Han; Wong, Tze Wai

    2008-02-01

    Data on patch test findings in Hong Kong are scarce, with the last survey performed more than 10 years ago. A retrospective analysis of results from all patch tests performed on patients with suspected allergic contact dermatitis from January 1995 to December 1999 in the Social Hygiene Service, which provides a public dermatology service in Hong Kong, was undertaken. We aimed to explore the demographic data associated with positive reactions and the profile of contact sensitizing allergens in Hong Kong. A total of 2585 patients were patch tested with the European standard series during the period. Most were Chinese, with a female-to-male ratio of 3 : 2. One or more positive responses were noted in 1415 patients (54.7%). The most common allergen was nickel sulfate (24.4%), followed by fragrance mix (13.7%), cobalt chloride (8.7%), p-phenylenediamine (6.0%), and balsam of Peru (5.7%). Nickel sensitivity was more common in female patients, and dichromate sensitivity was more common in male patients (P history were significant risk factors for nickel sensitivity. This study provides a profile of allergens responsible for allergic contact dermatitis in the public dermatology service in Hong Kong. A prospective study, using a larger panel of allergens, involving patients from both the private and public sectors, would provide a more comprehensive profile of contact allergens in Hong Kong and contribute to the establishment of a local standard series.

  15. Proposal evaluation tool of standards and procedures for breast cancer in the province of Cienfuegos

    International Nuclear Information System (INIS)

    Fraga Suarez, Omayda; Sabates Llerandi, Teresita; Arnot Silvera, Rogelio; Torres Aja, Lidia

    2009-01-01

    Breast cancer is one of the most frequent malignancies Although Cuba and be a program with rules and procedures established a high number of women will die from cause. Objectives, design an instrument to assess compliance with the rules and procedures of breast cancer in Cienfuegos Province. Methodological design, a study was conducted descriptive, during the time period from January 2007 to January 2008, whose study group consisted of 55 women diagnosed with breast cancer at the 'Hospital Universitario Dr. Gustavo Lima Aldereguia' of Cienfuegos, the research was divided into three stages: general characterization, design of an assessment tool, criterion validation by external evaluators. Methods were used theoretical, empirical and mathematical statistics. Results, the stadiums most representative were II and III, there are delays in the performance definitive surgery, radical surgical treatments prevail, delays in the initiation of chemotherapy. Findings, there difficulties in adherence and compliance and therapeutic procedures established in the province of Cienfuegos, by which an instrument was designed for evaluation. (Author)

  16. The advantages of using standardized review procedures in certifying type B radioactive material packages

    International Nuclear Information System (INIS)

    Easton, E.P.; Faille, S.

    2004-01-01

    This paper presents the advantages of adopting well-documented standardized review practices for reviewing Type B package designs. The US experience using standardized review plans and guidance has shown them to be a valuable tool in achieving more consistent and efficient package reviews, in training and qualifying technical reviewers, and in enhancing public and industry understanding of the package certification process. In addition, the standardized review practices, as living documents, have proven to be an effective method of incorporating new technical advances into the review process, and have provided a vehicle to make that knowledge widely available to fellow reviewers, the public and industry. Canada implemented a new internal review process in early 2003 to standardize the review of applications for certification of Type B Packages. Based on the similarity of these approaches, the United States and Canada have started discussions on a A North American System for the unilateral approval of Type B (U) packages. This initiative is looking into how each country is currently reviewing transportation package applications to see if agreement can be reached on accepting Type B certifications on a reciprocal basis, i.e., without additional review. Based on the experience in Canada and the United States, the authors believe that the use of standardized review processes, coupled with the knowledge and experience resident in IAEA's Transportation Advisory Material (TS-G-1.1) and series of TECDOCS, could also be used to develop a standard internationally accepted review process that could enhance the acceptance of unilateral approvals for Type B packages

  17. Vitamin D and mortality: Individual participant data meta-analysis of standardized 25-hydroxyvitamin D in 26916 individuals from a European consortium.

    Directory of Open Access Journals (Sweden)

    Martin Gaksch

    Full Text Available Vitamin D deficiency may be a risk factor for mortality but previous meta-analyses lacked standardization of laboratory methods for 25-hydroxyvitamin D (25[OH]D concentrations and used aggregate data instead of individual participant data (IPD. We therefore performed an IPD meta-analysis on the association between standardized serum 25(OHD and mortality.In a European consortium of eight prospective studies, including seven general population cohorts, we used the Vitamin D Standardization Program (VDSP protocols to standardize 25(OHD data. Meta-analyses using a one step procedure on IPD were performed to study associations of 25(OHD with all-cause mortality as the primary outcome, and with cardiovascular and cancer mortality as secondary outcomes. This meta-analysis is registered at ClinicalTrials.gov, number NCT02438488.We analysed 26916 study participants (median age 61.6 years, 58% females with a median 25(OHD concentration of 53.8 nmol/L. During a median follow-up time of 10.5 years, 6802 persons died. Compared to participants with 25(OHD concentrations of 75 to 99.99 nmol/L, the adjusted hazard ratios (with 95% confidence interval for mortality in the 25(OHD groups with 40 to 49.99, 30 to 39.99, and <30 nmol/L were 1.15 (1.00-1.29, 1.33 (1.16-1.51, and 1.67 (1.44-1.89, respectively. We observed similar results for cardiovascular mortality, but there was no significant linear association between 25(OHD and cancer mortality. There was also no significantly increased mortality risk at high 25(OHD levels up to 125 nmol/L.In the first IPD meta-analysis using standardized measurements of 25(OHD we observed an association between low 25(OHD and increased risk of all-cause mortality. It is of public health interest to evaluate whether treatment of vitamin D deficiency prevents premature deaths.

  18. 78 FR 54655 - Center for Devices and Radiological Health: Draft Standard Operating Procedure for Level 1...

    Science.gov (United States)

    2013-09-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF HEALTH AND... challenging for the Center to communicate the change and its basis to all affected parties in a meaningful and... communication on regulatory matters, including establishing a standard practice for communicating to all...

  19. Study on Design and Implementation of JAVA Programming Procedural Assessment Standard

    Science.gov (United States)

    Tingting, Xu; Hua, Ma; Xiujuan, Wang; Jing, Wang

    2015-01-01

    The traditional JAVA course examination is just a list of questions from which we cannot know students' skills of programming. According to the eight abilities in curriculum objectives, we designed an assessment standard of JAVA programming course that is based on employment orientation and apply it to practical teaching to check the teaching…

  20. Preliminary Guidelines and Standard Operating Procedure for Drainage and Erosion Control at McMurdo Station

    Science.gov (United States)

    2014-12-01

    along the impermeable frozen soil layer. Soil freeze–thaw action disrupts soil structures, displaces soils particles, and creates voids both in...appropriate culvert replacement type (e.g., metal or plastic or concrete , etc.) and to try to standardize culverts around the Station. ER D C

  1. CTEPP STANDARD OPERATING PROCEDURE FOR HANDLING SAMPLE AND DATA CUSTODY (SOP-2.26)

    Science.gov (United States)

    This SOP describes the method for handling sample custody. A standardized Chain-of-Custody (CoC) Record is used to document the sample/data custody. Each participant is assigned one CoC Record for the samples/data collected at their home and/or day care center.

  2. Incorporation of biomagnification in procedures for environmental risk assessment and standard setting

    NARCIS (Netherlands)

    Luttik R; Traas TP; de Greef J

    1992-01-01

    Recently methods have been developed in the Netherlands to assess quality standards for the environment. Maximum permissible concentrations have been derived for direct exposure to environmental media. In 1991 two simple foodchains were analyzed at the RIVM. - Water --> Fish --> Fish-eating

  3. Documentation for assessment of modal pushover-based scaling procedure for nonlinear response history analysis of "ordinary standard" bridges

    Science.gov (United States)

    Kalkan, Erol; Kwong, Neal S.

    2010-01-01

    The earthquake engineering profession is increasingly utilizing nonlinear response history analyses (RHA) to evaluate seismic performance of existing structures and proposed designs of new structures. One of the main ingredients of nonlinear RHA is a set of ground-motion records representing the expected hazard environment for the structure. When recorded motions do not exist (as is the case for the central United States), or when high-intensity records are needed (as is the case for San Francisco and Los Angeles), ground motions from other tectonically similar regions need to be selected and scaled. The modal-pushover-based scaling (MPS) procedure recently was developed to determine scale factors for a small number of records, such that the scaled records provide accurate and efficient estimates of 'true' median structural responses. The adjective 'accurate' refers to the discrepancy between the benchmark responses and those computed from the MPS procedure. The adjective 'efficient' refers to the record-to-record variability of responses. Herein, the accuracy and efficiency of the MPS procedure are evaluated by applying it to four types of existing 'ordinary standard' bridges typical of reinforced-concrete bridge construction in California. These bridges are the single-bent overpass, multi span bridge, curved-bridge, and skew-bridge. As compared to benchmark analyses of unscaled records using a larger catalog of ground motions, it is demonstrated that the MPS procedure provided an accurate estimate of the engineering demand parameters (EDPs) accompanied by significantly reduced record-to-record variability of the responses. Thus, the MPS procedure is a useful tool for scaling ground motions as input to nonlinear RHAs of 'ordinary standard' bridges.

  4. Standardization of solvent extraction procedure for determination of uranium in seawater

    International Nuclear Information System (INIS)

    Sukanta Maity; Sahu, S.K.; Pandit, G.G.

    2015-01-01

    Solvent extraction procedure using ammonium pyrolidine dithiocarbamate complexing agent in methyl isobutyl ketone organic phase and acid exchange back-extraction is described for the simultaneous quantitative pre-concentration of uranium in seawater followed by its determination by differential pulse adsorptive stripping voltammetry. Solvent extraction time is optimized for extraction of uranium from seawater. Solvent extraction efficiency for uranium in seawater at different pH was carried out. The method gives a recovery of 98 ± 2 % for 400 mL sample at pH 3.0 ± 0.02, facilitating the rapid and interference free analysis of seawater samples. (author)

  5. Developing standard performance testing procedures for MC and A components at a site

    International Nuclear Information System (INIS)

    Scherer, Carolynn

    2010-01-01

    The condition of a nuclear material control and accountability system (MC and A) and its individual components, as with any system combining technical elements, documentation and the human factor, may be characterized through an aggregate of values for the various parameters that determine the system's ability to perform. The MC and A system's status may be functioning effectively, marginally or not functioning based on a summary of the values of the individual parameters. This work included a review of the following elements and subsystems or components for a material control and accountability system: (1) MC and A Elements: Information subsystem, Measurement subsystem, NM access subsystem, including a tamper-indicating device (TID) program, and Automated information-gathering subsystem; and (2) Detecting NM Loses Elements: Inventory differences, Shipper/receiver differences, Confirmatory measurements and differences with accounting data, and TID or seal violations. In order to detect the absence or loss of nuclear material there must be appropriate interactions among the elements and their respective subsystems (from the list above). Additionally this work includes a review of the status of regulatory requirements for the MC and A system components and potential criteria that support the evaluation of the performance of the listed components. The listed components had performance testing algorithms and procedures developed that took into consideration the regulatory criteria. The developed MC and A performance-testing procedures were the basis for a pilot Guide for MC and A Performance Testing at the MBAs of SSC RF IPPE.

  6. Biobanking human endometrial tissue and blood specimens: standard operating procedure and importance to reproductive biology research and diagnostic development.

    Science.gov (United States)

    Sheldon, Elizabeth; Vo, Kim Chi; McIntire, Ramsey A; Aghajanova, Lusine; Zelenko, Zara; Irwin, Juan C; Giudice, Linda C

    2011-05-01

    To develop a standard operating procedure (SOP) for collection, transport, storage of human endometrial tissue and blood samples, subject and specimen annotation, and establishing sample priorities. The SOP synthesizes sound scientific procedures, the literature on ischemia research, sample collection and gene expression profiling, good laboratory practices, and the authors' experience of workflow and sample quality. The National Institutes of Health, University of California, San Francisco, Human Endometrial Tissue and DNA Bank. Women undergoing endometrial biopsy or hysterectomy for nonmalignant indications. Collecting, processing, storing, distributing endometrial tissue and blood samples under approved institutional review board protocols and written informed consent from participating subjects. Standard operating procedure. The SOP addresses rigorous and consistent subject annotation, specimen processing and characterization, strict regulatory compliance, and a reference for researchers to track collection and storage times that may influence their research. The comprehensive and systematic approach to the procurement of human blood and endometrial tissue in this SOP ensures the high quality, reliability, and scientific usefulness of biospecimens made available to investigators by the National Institutes of Health, University of California, San Francisco, Human Endometrial Tissue and DNA Bank. The detail and perspective in this SOP also provides a blueprint for implementation of similar collection programs at other institutions. Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  7. Trust in the employer: The role of high-involvement work practices and procedural justice in European organizations

    NARCIS (Netherlands)

    Searle, R.; den Hartog, D.N.; Weibel, A.; Gillespie, N.; Six, F.; Hatzakis, T.; Skinner, D.

    2011-01-01

    Despite the central role of trust in the organizational sciences, we know little about what makes people trust the organizations they work for. This paper examines the antecedents of employees' trust in their organizations drawing on survey data from over 600 European professional workers and

  8. New Data Security Requirements and the Proceduralization of Mass Surveillance Law after the European Data Retention Case

    NARCIS (Netherlands)

    Zuiderveen Borgesius, F.; Arnbak, A.

    2015-01-01

    This paper discusses the regulation of mass metadata surveillance in Europe through the lens of the landmark judgment in which the Court of Justice of the European Union struck down the Data Retention Directive. The controversial directive obliged telecom and Internet access providers in Europe to

  9. The use of faces as stimuli in neuroimaging and psychological experiments: a procedure to standardize stimulus features.

    Science.gov (United States)

    Gronenschild, Ed H B M; Smeets, Floortje; Vuurman, Eric F P M; van Boxtel, Martin P J; Jolles, Jelle

    2009-11-01

    In psychological experiments involving facial stimuli, it is of great importance that the basic perceptual or psychological characteristics that are investigated are not confounded by factors such as brightness and contrast, head size, hair cut and color, skin color, and the presence of glasses and earrings. Standardization of facial stimulus materials reduces the effect of these confounding factors. We therefore employed a set of basic image processing techniques to deal with this issue. The processed images depict the faces in grayscale, all at the same size, brightness, and contrast, and confined to an oval mask revealing only the basic features such as the eyes, nose, and mouth. The standardization was successfully applied to four different face databases, consisting of male and female faces and including neutral as well as happy facial expressions. An important advantage of the proposed standardization is that featural as well as configurational information is retained. We also consider the procedure to be a major contribution to the development of a de facto standard for the use of facial stimuli in psychological experiments. Such methodological standardization would allow a better comparison of the results of these studies.

  10. Developing standard performance testing procedures for material control and accounting components at a site

    International Nuclear Information System (INIS)

    Scherer, Carolynn P.; Bushlya, Anatoly V.; Efimenko, Vladimir F.; Ilyanstev, Anatoly; Regoushevsky, Victor I.

    2010-01-01

    The condition of a nuclear material control and accountability system (MC and A) and its individual components, as with any system combining technical elements and documentation, may be characterized through an aggregate of values for the various parameters that determine the system's ability to perform. The MC and A system's status may be functioning effectively, marginally or not functioning based on a summary of the values of the individual parameters. This work included a review of the following subsystems, MC and A and Detecting Material Losses, and their respective elements for the material control and accountability system: (a) Elements of the MC and A Subsystem - Information subsystem (Accountancy/Inventory), Measurement subsystem, Nuclear Material Access subsystem, including tamper-indicating device (TID) program, and Automated Information-gathering subsystem; (b) Elements for Detecting Nuclear Material Loses Subsystem - Inventory Differences, Shipper/receiver Differences, Confirmatory Measurements and differences with accounting data, and TID or Seal Violations. In order to detect the absence or loss of nuclear material there must be appropriate interactions among the elements and their respective subsystems from the list above. Additionally this work includes a review of regulatory requirements for the MC and A system component characteristics and criteria that support the evaluation of the performance of the listed components. The listed components had performance testing algorithms and procedures developed that took into consideration the regulatory criteria. The developed MC and A performance-testing procedures were the basis for a Guide for MC and A Performance Testing at the material balance areas (MBAs) of State Scientific Center of the Russian Federation - Institute for Physics and Power Engineering (SSC RF-IPPE).

  11. [Nomenclature and classification of complications. Standard procedure at the Heidelberg University Orthopedic Clinic].

    Science.gov (United States)

    Krämer, K L; Clauss, M

    1999-03-01

    In order to get a better data management of complications in orthopedic surgery and in order to get comparable statistics a standardisation of nomenclature and classification of complications is demanded since 1.1.1997. The Orthopedic University Clinic of Heidelberg started with a register of all early complications of all inpatients. According to a standardized nomenclature all occurred complications the doctors put in the data of complications in a database. These data were controlled, complemented and classified by members of the quality management group. This guideline consists of five parts: catalogue of diagnoses, general and special definitions, classification and an allocation table of diagnoses to grades of severity.

  12. Assessment of modal-pushover-based scaling procedure for nonlinear response history analysis of ordinary standard bridges

    Science.gov (United States)

    Kalkan, E.; Kwong, N.

    2012-01-01

    The earthquake engineering profession is increasingly utilizing nonlinear response history analyses (RHA) to evaluate seismic performance of existing structures and proposed designs of new structures. One of the main ingredients of nonlinear RHA is a set of ground motion records representing the expected hazard environment for the structure. When recorded motions do not exist (as is the case in the central United States) or when high-intensity records are needed (as is the case in San Francisco and Los Angeles), ground motions from other tectonically similar regions need to be selected and scaled. The modal-pushover-based scaling (MPS) procedure was recently developed to determine scale factors for a small number of records such that the scaled records provide accurate and efficient estimates of “true” median structural responses. The adjective “accurate” refers to the discrepancy between the benchmark responses and those computed from the MPS procedure. The adjective “efficient” refers to the record-to-record variability of responses. In this paper, the accuracy and efficiency of the MPS procedure are evaluated by applying it to four types of existing Ordinary Standard bridges typical of reinforced concrete bridge construction in California. These bridges are the single-bent overpass, multi-span bridge, curved bridge, and skew bridge. As compared with benchmark analyses of unscaled records using a larger catalog of ground motions, it is demonstrated that the MPS procedure provided an accurate estimate of the engineering demand parameters (EDPs) accompanied by significantly reduced record-to-record variability of the EDPs. Thus, it is a useful tool for scaling ground motions as input to nonlinear RHAs of Ordinary Standard bridges.

  13. AN APPLE GRADING SYSTEM ACCORDING TO EUROPEAN FRUIT QUALITY STANDARDS USING GABOR FILTER AND ARTIFICIAL NEURAL NETWORKS

    Directory of Open Access Journals (Sweden)

    KEYVAN ASEFPOUR VAKILIAN

    2016-04-01

    Full Text Available With the advent of applications of machine learning methods in food engineering in recent decades, several intelligent methods have been introduced in fruit grading technology. In this study, an apple grading system is presented using image’s textural features extraction and artificial intelligence. The objective of this study was to simplify the use of Gabor filter in classification of two varieties of apple fruits (Golden Delicious and Red Delicious in four categories according to the European fruit quality standards. Using this filter, neural network classifier was trained for four category grading of the fruits. Two textural parameters were extracted from each obtained image: mean and variance of energy values of obtained image representing image’s luminous intensity and contrast, respectively. Experimental results indicated that the training of extracted features of about 350 fruits enabled the network to classify the test samples with appropriate accuracy. Compared to the state-of-the-art, the proposed grading categories (‘Extra’, ‘Type 1’, ‘Type 2’ and ‘Rejected’ classes achieved acceptable recognition rates of about 89 % and 92 % overall accuracy for Golden Delicious and Red Delicious varieties, respectively. These experimental results show the appropriate application of proposed method in fast grading of apple fruits. Furthermore, proposed feature extraction and network training methods can be used efficiently in online applications.

  14. Safety effects of road design standards : a study commissioned by the European Commission DG VII of the situation in the European Union.

    NARCIS (Netherlands)

    Ruyters, H.G.J.C.M. Slop, M. & Wegman, F.C.M. (eds.)

    1994-01-01

    This report describes the results of a study carried out for the European Union. The report uses the safety principle that: (i) proper road design is crucial to prevent human errors in traffic; and (ii) less human errors will result in less accidents. The study contains the following parts: (1)

  15. Analysis of global variability in 15 established and 5 new European Standard Set (ESS) STRs using the CEPH human genome diversity panel

    DEFF Research Database (Denmark)

    Philips, C.; Fernandez-Formoso, L.; Garcia-Magarinos, M.

    2011-01-01

    five recently introduced European Standard Set (ESS) STRs: D1S1656, D2S441, D10S1248, D12S391 and D22S1045. From the genotypes obtained for the ESS STRs we identified rare, intermediate or off-ladder alleles that had not been previously reported for these loci. Examples of novel ESS STR alleles found...

  16. The Importance and Degree of Implementation of the European Standards and Guidelines for Internal Quality Assurance in Universities: The Views of Portuguese Academics

    Science.gov (United States)

    Manatos, Maria J.; Rosa, Maria J.; Sarrico, Cláudia S.

    2015-01-01

    This research seeks to explore academics' perceptions of the importance and degree of implementation of the Standards and Guidelines for Quality Assurance in the European Higher Education Area (ESG) for internal quality assurance. It uses empirical evidence from Portugal, gathered via a questionnaire given to all university academics. Results show…

  17. Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Câmara-Costa, Hugo, E-mail: hugocamaracosta@gmail.com [National Institute of Health and Medical Research, INSERM U1178, Paris (France); Resch, Anika [University Medical Center Hamburg-Eppendorf, Hamburg (Germany); Kieffer, Virginie [Saint Maurice Hospitals, Saint Maurice (France); Lalande, Clémence [Institut Gustave Roussy, Villejuif (France); Poggi, Geraldina [Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Lecco (Italy); Kennedy, Colin; Bull, Kim [University of Southampton, Faculty of Medicine, Southampton (United Kingdom); Calaminus, Gabriele [Paediatric Oncology, University of Muenster, Muenster (Germany); Grill, Jacques [Institut Gustave Roussy, Villejuif (France); Doz, François [Institut Curie and University Paris Descartes, Sorbonne Paris Cité, Paris (France); Rutkowski, Stefan [University Medical Center Hamburg-Eppendorf, Hamburg (Germany); Massimino, Maura [Fondazione IRCCS, Istituto Nazionale Tumori, Milan (Italy); Kortmann, Rolf-Dieter [Department of Radiation Therapy, University of Leipzig, Leipzig (Germany); Lannering, Birgitta [Paediatric Oncology, University of Gothenburg, Gothenburg (Sweden); Dellatolas, Georges [National Institute of Health and Medical Research, INSERM U1178, Paris (France); Chevignard, Mathilde [Rehabilitation Department for Children With Acquired Neurological Injury, Saint Maurice Hospitals, Saint Maurice, and Sorbonne Universités, UPMC Universités Paris, INSERM CNRS, Paris (France)

    2015-08-01

    Purpose: In the European HIT-SIOP PNET4 randomized controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy (HFRT arm, including a partially focused boost) or standard radiation therapy (STRT arm), followed, in both arms, by maintenance chemotherapy. Event-free survival was similar in both arms. Previous work showed that the HFRT arm was associated with worse growth and better questionnaire-based executive function, especially in children <8 years of age at diagnosis. Therefore, the aim of this study was to compare performance-based cognitive outcomes between treatment arms. Methods and Materials: Neuropsychological data were collected prospectively in 137 patients. Using the Wechsler Intelligence Scales, Kaufman Assessment Battery for Children, and Raven's Progressive Matrices, we estimated full-scale intelligence quotient (FSIQ) and, when available, verbal IQ (VIQ), performance IQ (PIQ), working memory index (WMI), and processing speed index (PSI). Results: Among the 137 participants (HFRT arm n=71, STRT arm n=66, 63.5% males), mean (±SD) ages at diagnosis and assessment respectively were 9.3 (±3.2) years of age (40.8% < 8 years of age at diagnosis) and 14.6 (±4.3) years of age. Mean (±SD) FSIQ was 88 (±19), and mean intergroup difference was 3.88 (95% confidence interval: −2.66 to 10.42, P=.24). No significant differences were found in children >8 years of age at diagnosis. In children <8 years of age at diagnosis, a marginally significant trend toward higher VIQ was found in those treated in the HFRT arm; a similar trend was found for PSI but not for PIQ, WMI, or FSIQ (mean intergroup differences were: 12.02 for VIQ [95% CI: 2.37-21.67; P=.02]; 3.77 for PIQ [95% CI: −5.19 to 12.74; P>.10]; 5.20 for WMI [95% CI: −2.07 to 12.47; P>.10]; 10.90 for PSI [95% CI: −1.54 to 23.36; P=.08]; and 5.28 for FSIQ [95% CI: −4.23 to 14.79; P>.10]). Conclusions: HFRT was associated with

  18. Neuropsychological Outcome of Children Treated for Standard Risk Medulloblastoma in the PNET4 European Randomized Controlled Trial of Hyperfractionated Versus Standard Radiation Therapy and Maintenance Chemotherapy

    International Nuclear Information System (INIS)

    Câmara-Costa, Hugo; Resch, Anika; Kieffer, Virginie; Lalande, Clémence; Poggi, Geraldina; Kennedy, Colin; Bull, Kim; Calaminus, Gabriele; Grill, Jacques; Doz, François; Rutkowski, Stefan; Massimino, Maura; Kortmann, Rolf-Dieter; Lannering, Birgitta; Dellatolas, Georges; Chevignard, Mathilde

    2015-01-01

    Purpose: In the European HIT-SIOP PNET4 randomized controlled trial, children with standard risk medulloblastoma were allocated to hyperfractionated radiation therapy (HFRT arm, including a partially focused boost) or standard radiation therapy (STRT arm), followed, in both arms, by maintenance chemotherapy. Event-free survival was similar in both arms. Previous work showed that the HFRT arm was associated with worse growth and better questionnaire-based executive function, especially in children <8 years of age at diagnosis. Therefore, the aim of this study was to compare performance-based cognitive outcomes between treatment arms. Methods and Materials: Neuropsychological data were collected prospectively in 137 patients. Using the Wechsler Intelligence Scales, Kaufman Assessment Battery for Children, and Raven's Progressive Matrices, we estimated full-scale intelligence quotient (FSIQ) and, when available, verbal IQ (VIQ), performance IQ (PIQ), working memory index (WMI), and processing speed index (PSI). Results: Among the 137 participants (HFRT arm n=71, STRT arm n=66, 63.5% males), mean (±SD) ages at diagnosis and assessment respectively were 9.3 (±3.2) years of age (40.8% < 8 years of age at diagnosis) and 14.6 (±4.3) years of age. Mean (±SD) FSIQ was 88 (±19), and mean intergroup difference was 3.88 (95% confidence interval: −2.66 to 10.42, P=.24). No significant differences were found in children >8 years of age at diagnosis. In children <8 years of age at diagnosis, a marginally significant trend toward higher VIQ was found in those treated in the HFRT arm; a similar trend was found for PSI but not for PIQ, WMI, or FSIQ (mean intergroup differences were: 12.02 for VIQ [95% CI: 2.37-21.67; P=.02]; 3.77 for PIQ [95% CI: −5.19 to 12.74; P>.10]; 5.20 for WMI [95% CI: −2.07 to 12.47; P>.10]; 10.90 for PSI [95% CI: −1.54 to 23.36; P=.08]; and 5.28 for FSIQ [95% CI: −4.23 to 14.79; P>.10]). Conclusions: HFRT was associated with

  19. Microspectrophotometric studies of Romanowsky stained blood cells. I. Subtraction analysis of a standardized procedure.

    Science.gov (United States)

    Galbraith, W; Marshall, P N; Bacus, J W

    1980-08-01

    This paper describes a microspectrophotometric study of blood smears stained by a simple, standardized Romanowsky technique, using only the dyes azure B and cosin. Absorbance spectra are presented for twenty-two classes of cellular object, and for the two dyes in solution, together with tabulations of spectral maxima, and suitable wavelengths for use in automated image processing. The colours of objects stained with azure B/eosin are discussed in terms of absorbance spectra. By a spectral subtraction technique, it is shown that the differential colouration of various cell structures may be explained satisfactorily in terms of the varying proportions of only four dye components. These are the monomers and dimers of azure B and eosin. Polymerization was found to occur both in solution and on binding to biopolymers. A similar analysis of a conventional Romanowsky stain would present much greater difficulties, due to the greater number of dye components, which, however, contribute little to the colours observed.

  20. STANDARDIZATION OF PROCEDURES OF Plasmodium falciparum ANTIGEN PREPARATION FOR SEROLOGIC TESTS

    Directory of Open Access Journals (Sweden)

    Sandra L.M. AVILA

    1998-09-01

    Full Text Available The objective of the present study is to standardize the technical variables for preparation and storage of Plasmodium falciparum and of antigen components extracted with the amphoteric detergent Zwittergent. P. falciparum obtained from in vitro culture was stored at different temperatures and for different periods of time. For each variable, antigen components of the parasite were extracted in the presence or absence of protease inhibitors and submitted or not to later dialysis. Products were stored for 15, 30 and 60 days at different temperatures and immunological activity of each extract was determined by SDS-PAGE and ELISA using positive or negative standard sera for the presence of IgG directed to blood stage antigens of P. falciparum. Antigen extracts obtained from parasites stored at -20oC up to 10 days or at -70oC for 2 months presented the best results, showing well-defined bands on SDS-PAGE and Western blots and presenting absorbance values in ELISA that permitted safe differentiation between positive and negative sera.O objetivo deste estudo foi padronizar variáveis técnicas para o armazenamento de Plasmodium falciparum e de seus componentes antigênicos. Sedimentos de parasitas foram obtidos do cultivo in vitro de P.falciparum e estocados em diferentes temperaturas por diferentes períodos de tempo. De cada variável, foram extraídos os componentes antigênicos com detergente anfótero Zwittergent na presença e na ausência de inibidores de proteases e submetidos ou não a posterior diálise. Os produtos foram estocados por 15, 30 e 60 dias em diferentes temperaturas e caracterizados por SDS-PAGE. A atividade antigênica de cada extrato foi determinada por ELISA e Western blotting usando soros positivos e negativos para anticorpos IgG anti-formas eritrocitárias de P.falciparum. Os extratos antigênicos obtidos de parasitas estocados até 10 dias a _20ºC ou por 2 meses a _70ºC e tratados com inibidores de proteases, sob as

  1. Two-loop renormalization in the standard model, part II. Renormalization procedures and computational techniques

    Energy Technology Data Exchange (ETDEWEB)

    Actis, S. [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany); Passarino, G. [Torino Univ. (Italy). Dipt. di Fisica Teorica; INFN, Sezione di Torino (Italy)

    2006-12-15

    In part I general aspects of the renormalization of a spontaneously broken gauge theory have been introduced. Here, in part II, two-loop renormalization is introduced and discussed within the context of the minimal Standard Model. Therefore, this paper deals with the transition between bare parameters and fields to renormalized ones. The full list of one- and two-loop counterterms is shown and it is proven that, by a suitable extension of the formalism already introduced at the one-loop level, two-point functions suffice in renormalizing the model. The problem of overlapping ultraviolet divergencies is analyzed and it is shown that all counterterms are local and of polynomial nature. The original program of 't Hooft and Veltman is at work. Finite parts are written in a way that allows for a fast and reliable numerical integration with all collinear logarithms extracted analytically. Finite renormalization, the transition between renormalized parameters and physical (pseudo-)observables, are discussed in part III where numerical results, e.g. for the complex poles of the unstable gauge bosons, are shown. An attempt is made to define the running of the electromagnetic coupling constant at the two-loop level. (orig.)

  2. OIE philosophy, policy and procedures for the development of food safety standards.

    Science.gov (United States)

    Droppers, W F G L

    2006-08-01

    Food safety was identified as a high priority area in the 2001-2005 World Organisation for Animal Health (OIE) Strategic Plan. Member Countries of the OIE considered that the organisation should be more active in issues of public health and consumer protection and that this should include more involvement in the area of diseases or pathogens transmissible through food, whether or not animals are affected by such diseases or pathogens. A permanent Working Group on Animal Production Food Safety was established in 2002 to coordinate the OIE's activities in food safety. The Working Group was requested to focus on food safety measures applicable at farm level and to monitor the ongoing cooperation between the OIE and Codex Alimentarius. More emphasis is now placed on the public health aspects of a disease when OIE standards are developed or revised. For example, the revised chapter on bovine tuberculosis in the Terrestrial Animal Health Code includes food safety recommendations for meat and meat products and for milk and milk products. The revised chapter was approved by the OIE International Committee of Member Countries at their 73rd General Session in May 2005. More chapters will follow, beginning with a chapter addressing bovine brucellosis.

  3. Novel femoral artery terminology: integrating anatomy and clinical procedures leading to standardized intuitive nomenclature.

    Science.gov (United States)

    Benninger, Brion

    2014-10-01

    The objective of this study is to investigate the terminology of the femoral artery and recommended alternative terminology that satisfies both anatomy and clinical arenas.The femoral artery (FA) is often defined as the continuation of the external iliac artery. Specifically, when the external iliac artery reaches directly beneath the inguinal ligament, it becomes the FA. Currently, Terminologia Anatomica (TA) records the profunda femoris or deep femoral as a terminal branch. Clinicians often use superficial femoral artery (SFA) rather than FA and profunda or deep FA. SFA is actually very deep and well protected for most of its journey. On observation, the terminology in current use is not intuitive. The objective of this study was to investigate the terminology associated with the anatomical and clinical anatomical interpretations of the FA and its terminal branches and to suggest a more appropriate terminology that addresses the points of view of the macro anatomist, as well as that of the clinician. Literature search was conducted regarding the nomenclature of the FA and its terminal branches. Dissection of 89 embalmed cadavers (49F, 40M, ages 47-89) was conducted to analyze the morphology of the FA and its branches. Perusal of the literature revealed a difference in terminology between anatomical and clinical textbooks/atlases/journals regarding the FA and its terminal branch. Our dissections suggested that the FA may be better defined vis-à-vis its relationship to the anterior and posterior compartments of the thigh. A difference in terminology exists between the anatomical and clinical arenas. A need for a standardized terminology is necessary because clinicians and their publishers have not adopted TA. This study suggests that the current FA be considered the common FA and the continuation of the FA, the SFA be renamed the anterior FA and the current profunda (the deep FA) be renamed the posterior FA, respectively. The proposed terminology mirrors the lower

  4. Tools, harmonization and standardization procedures of the impact and outcome evaluation indices obtained during a kindergarten-based, family-involved intervention to prevent obesity in early childhood: the ToyBox-study.

    Science.gov (United States)

    Mouratidou, T; Miguel, M L; Androutsos, O; Manios, Y; De Bourdeaudhuij, I; Cardon, G; Kulaga, Z; Socha, P; Galcheva, S; Iotova, V; Payr, A; Koletzko, B; Moreno, L A

    2014-08-01

    The ToyBox-intervention is a kindergarten-based, family-involved intervention targeting multiple lifestyle behaviours in preschool children, their teachers and their families. This intervention was conducted in six European countries, namely Belgium, Bulgaria, Germany, Greece, Poland and Spain. The aim of this paper is to provide a descriptive overview of the harmonization and standardization procedures of the baseline and follow-up evaluation of the study (and substudies). Steps related to the study's operational, standardization and harmonization procedures as well as the impact and outcome evaluation assessment tools used are presented. Experiences from the project highlight the importance of safeguarding the measurement process to minimize data heterogeneity derived from potential measurement error and country-by-country differences. In addition, it was made clear that continuing quality control and support is an important component of such studies. For this reason, well-supported communication channels, such as regular email updates and teleconferences, and regular internal and external meetings to ensure smooth and accurate implementation were in place during the study. The ToyBox-intervention and its harmonized and standardized procedures can serve as a successful case study for future studies evaluating the efficacy of similar interventions. © 2014 World Obesity.

  5. The Consolidated Standards of Reporting Trials (CONSORT) Statement applied to allergen-specific immunotherapy with inhalant allergens: a Global Allergy and Asthma European Network (GA(2)LEN) article.

    Science.gov (United States)

    Bousquet, Philippe J; Calderón, Moisés A; Demoly, Pascal; Larenas, Désirée; Passalacqua, Giovanni; Bachert, Claus; Brozek, Jan; Canonica, G Walter; Casale, Thomas; Fonseca, Joao; Dahl, Ronald; Durham, Stephen R; Merk, Hans; Worm, Margitta; Wahn, Ulrich; Zuberbier, Torsten; Schünemann, Holger J; Bousquet, Jean

    2011-01-01

    Randomized trials provide evidence to inform treatment decisions. The Consolidated Standards of Reporting Trials (CONSORT) Statement is a set of recommendations for the reporting of trials. We sought to assess the quality of reporting allergen-specific immunotherapy trials according to CONSORT criteria. The reporting of the procedure, randomization, dropouts, strict conduct of intention-to-treat (ITT) analysis, and sample size calculation according to CONSORT were assessed in the 46 subcutaneous and 48 sublingual immunotherapy (SLIT) blind, placebo-controlled randomized trials published between 1996 and 2009 in English. One subcutaneous immunotherapy (2.2%) and 3 SLIT (6.6%) trials met CONSORT Statement criteria. These were used for the registration of sublingual tablets to the European Medicines Agency. In subcutaneous immunotherapy, 16 (35%) studies reported a CONSORT flow chart, and 12 (26%) provided a description of dropouts. Adequate randomization was reported in 9 (35%) studies, and incomplete randomization was reported in 15 (33%). Power analysis was reported in 15 (33%) studies. In SLIT, 20 (42%) studies reported a CONSORT flow chart, and 16 (32%) a description of dropouts. ITT analysis was carried out in 1 (2.2%) SLIT study, and a modified ITT analysis was used in 1 (2.2%) subcutaneous immunotherapy study and 2 (4.4%) SLIT studies. Adequate randomization was reported in 6 (12%) studies, and incomplete randomization was reported in 16 (32%). Power analysis was reported in 15 (27%) studies. As in other areas of medicine, the quality of reporting of most immunotherapy trials is low, and only 4.2% of SLIT randomized controlled trials met all of the criteria of the CONSORT Statement. Use of the CONSORT criteria should be encouraged. Copyright © 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.

  6. What European gynaecologists need to master: Consensus on medical expertise outcomes of pan-European postgraduate training in obstetrics & gynaecology.

    Science.gov (United States)

    van der Aa, Jessica E; Tancredi, Annalisa; Goverde, Angelique J; Velebil, Petr; Feyereisl, Jaroslav; Benedetto, Chiara; Teunissen, Pim W; Scheele, Fedde

    2017-09-01

    European harmonisation of training standards in postgraduate medical education in Obstetrics and Gynaecology is needed because of the increasing mobility of medical specialists. Harmonisation of training will provide quality assurance of training and promote high quality care throughout Europe. Pan-European training standards should describe medical expertise outcomes that are required from the European gynaecologist. This paper reports on consensus development on the medical expertise outcomes of pan-European training in Obstetrics and Gynaecology. A Delphi procedure was performed amongst European gynaecologists and trainees in Obstetrics & Gynaecology, to develop consensus on outcomes of training. The consensus procedure consisted of two questionnaire rounds, followed by a consensus meeting. To ensure reasonability and feasibility for implementation of the training standards in Europe, implications of the outcomes were considered in a working group thereafter. We invited 142 gynaecologists and trainees in Obstetrics & Gynaecology for participation representing a wide range of European countries. They were selected through the European Board & College of Obstetrics and Gynaecology and the European Network of Trainees in Obstetrics & Gynaecology. Sixty people participated in round 1 and 2 of the consensus procedure, 38 (63.3%) of whom were gynaecologists and 22 (36.7%) were trainees in Obstetrics & Gynaecology. Twenty-eight European countries were represented in this response. Round 3 of the consensus procedure was performed in a consensus meeting with six experts. Implications of the training outcomes were discussed in a working group meeting, to ensure reasonability and feasibility of the material for implementation in Europe. The entire consensus procedure resulted in a core content of training standards of 188 outcomes, categorised in ten topics. European consensus was developed regarding the medical expertise outcomes of pan-European training in Obstetrics and

  7. Standardization and optimization of core sampling procedure for carbon isotope analysis in eucalyptus and variation in carbon isotope ratios across species and growth conditions

    CSIR Research Space (South Africa)

    Raju, M

    2011-11-01

    Full Text Available 13C is a well established surrogate for water use efficiency (WUE). However, variation due to aspect, length of branch and position In canopy can cause potential errors. Hence, experiments were conducted to standardize the sampling procedures...

  8. The main directions of adaptation regulation of admission to market of road transport in Ukraine according to European Union standards

    Directory of Open Access Journals (Sweden)

    V. A. Balin

    2014-10-01

    The peculiarities of legal regulation of individual elements of the transport sector, in particular concerning common rules for access to the market of transport services. In this regard, special attention is paid to the analysis of the Law of Ukraine «On the State Program of Adaptation of Ukraine to the European Union», the Association Agreement between Ukraine and the European Union and the relevant regulations of the European Union. Reveals the order in which the following requirements for companies involved in the activities of road transport operator. Considerable attention is paid to the coverage of liberalization road transport.

  9. Overweight and obesity in European children: definition and diagnostic procedures, risk factors and consequences for later health outcome.

    Science.gov (United States)

    Wabitsch, M

    2000-09-01

    In this article, information on the definition of obesity in childhood and adolescence, its differential diagnosis and its adverse health effects is provided. This information can be considered as a basis for the evaluation of an obese patient. Review of the international and European literature shows that the co-morbidities of childhood obesity cover a large medical area ranging from secondary hormonal disturbances to orthopaedic problems. Most of them have so far been underestimated. However, the most severe problem of an obese child is his or her psychosocial discrimination. Longitudinal data demonstrate a positive relationship between childhood obesity and increased morbidity and mortality in adulthood. Data from the literature are in some respect sparce since they do not allow to calculate the exact prevalence of adverse effects nor to assess the outcome of an obese child when it is successfully reducing the relative amount of body fat.

  10. A Guide for Developing Standard Operating Job Procedures for the Tertiary Chemical Treatment - Lime Precipitation Process Wastewater Treatment Facility. SOJP No. 6.

    Science.gov (United States)

    Petrasek, Al, Jr.

    This guide describes the standard operating job procedures for the tertiary chemical treatment - lime precipitation process of wastewater treatment plants. Step-by-step instructions are given for pre-start up, start-up, continuous operation, and shut-down procedures. In addition, some theoretical material is presented along with some relevant…

  11. Airborne particulates. European directives and standardization; Matieres particulaires dans l`air ambiant directives europeennes et normalisation

    Energy Technology Data Exchange (ETDEWEB)

    Houdret, J.L. [Ecole Nationale Superieure des Mines, 59 - Douai (France)

    1996-12-31

    The development of future European directives concerning atmospheric dusts and particulates, organization of the in-charge committee, measurement requirements and limit value determination processes are presented. Various measuring methods and instruments used for particulate and aerosol measurements are reviewed

  12. Sexual Desire and Hypoactive Sexual Desire Disorder in Women. Introduction and Overview. Standard Operating Procedure (SOP Part 1)

    DEFF Research Database (Denmark)

    Bitzer, Johannes; Giraldi, Annamaria; Pfaus, Jim

    2013-01-01

    Introduction.  Hypoactive sexual desire disorder (HSDD) is defined in Diagnostic and Statistical Manual of Mental Disorders Fourth Edition as persistent or recurrent deficiency (or absence) of sexual fantasies/thoughts, and/or desire for or receptivity to sexual activity, which causes personal......-factor models (e.g., excitation-inhibition, appetitive-consummatory) or more specific multifactorial models (in which the different components of sexual activity and their interaction are delineated). The etiology of the disorder is generally considered as multifactorial. Biomedical factors like diseases, drugs...... must be based on a biopsychosocial, multidimensional, and integrative perspective. Bitzer J, Giraldi A, and Pfaus J. Sexual desire and hypoactive sexual desire disorder in women. Introduction and overview. Standard operating procedure (SOP part 1). J Sex Med **;**:**-**....

  13. Removal of foot-and-mouth disease virus infectivity in salted natural casings by minor adaptation of standardized industrial procedures.

    Science.gov (United States)

    Wijnker, J J; Haas, B; Berends, B R

    2007-04-10

    Intestines are used for the production of natural casings as edible sausage containers. Derived from animals (pigs and sheep) experimentally infected with FMDV (initial dosage 10(7.3) PFU/ml, strain O(1Kaufbeuren)), these natural casings were treated with sodium chloride or a phosphate salts/sodium chloride mixture and the residual FMDV titres measured. After storage at about 20 degrees C, no remaining infectivity was found after either treatment, whereas casings stored at 4 degrees C still contained infectivity. Storage of salted casings at about 20 degrees C for 30 days is already part of the Standard Operating Procedures (included in HACCP) of the international casing industry and can therefore be considered as a protective measure for the international trade in natural casings.

  14. Design of standard operating procedure production proceses (case study on the home industry Bedugul Baturiti Tabanan Bali)

    Science.gov (United States)

    Kasiani; Suhantono, Djoko; Mirah Kencanawati, AAA

    2018-01-01

    Candikuning is part of the district of Baturiti, tourism village, better known by the name of Bedugul. No less interesting is the variety of chips produced by two partner groups as a souvenir after the tour, such as Chips: Spinach; beans; Tempeh. The purpose of this research were to design a Standard Operating Procedure (SOP): Production Processes on the Home Industry Bedugul Baturiti Tabanan Bali. The data technic collected use: observation; Documentation; and then interview to collect information. The data analysis technic done by using the Miles & Huberman. Result this research that the draft SOP: Production Processes Chips (Menu). The conclusion in this research SOP Production Processes use with flowchart and description on the Home Industry Bedugul Baturiti Tabanan Bali.

  15. Assessment of macrofungal diversity in a Silver Fir plantation in Sardinia (Italy using a standardized sampling procedure

    Directory of Open Access Journals (Sweden)

    Elia Ambrosio

    2015-12-01

    Full Text Available The knowledge of macrofungal diversity associated with Silver Fir forests in Italy is quite scarce. Only a little information is available about macrofungal communities from some Ligurian and Tuscan Silver Fir sites. This study aims to assess the macrofungal diversity of a Silver Fir plantation in Sardinia by the application of a standardized sampling procedure. A total of 606 sporomata were collected and 52 Basidiomycota were identified. The high value of the Shannon Index indicated a considerable level of macrofungal diversity in this plantation. The results were also compared with the diversity indices obtained by a previous 3-years long sampling methodology in the same site. The comparison of the macrofungal diversity values of the Sardinian site with those of the Ligurian Silver Fir forest revealed interesting similarities among natural versus planted coniferous forests.

  16. Standardization of digestion procedure for the determination of heavy metals in biological materials by atomic absorption spectrometry

    International Nuclear Information System (INIS)

    Khalid, N.; Chaudhri, S.A.

    1999-01-01

    Proper decomposition of the sample is one of the basic requirements of the atomic absorption spectroscopic analysis. In the present studies, heavy metals (Cu, Fe, Mn and Zn) were determined in biological samples by designating them in a mixture of nitric acid and perchloric acid. The quantification was made with atomic absorption spectrometry using an air-acetylene flame. The reliability of the procedure used was checked by analysing standard reference materials from NBS and IAEA, such as Rice flour (NBS-SRM-1568), Horse Kidney (IAEA H-8), Mixed Human diet(IAEA H-9), Copepod (IAEA MA-A-1) and fish flesh (IAEA MA-A-2) under identical conditions. A good agreement was observed between determined and the certified values reported by NBS and IAEA. (author)

  17. Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks

    International Nuclear Information System (INIS)

    Bernini, Patrizia; Bertini, Ivano; Luchinat, Claudio; Nincheri, Paola; Staderini, Samuele; Turano, Paola

    2011-01-01

    1 H NMR metabolic profiling of urine, serum and plasma has been used to monitor the impact of the pre-analytical steps on the sample quality and stability in order to propose standard operating procedures (SOPs) for deposition in biobanks. We analyzed the quality of serum and plasma samples as a function of the elapsed time (t = 0−4 h) between blood collection and processing and of the time from processing to freezing (up to 24 h). The stability of the urine metabolic profile over time (up to 24 h) at various storage temperatures was monitored as a function of the different pre-analytical treatments like pre-storage centrifugation, filtration, and addition of the bacteriostatic preservative sodium azide. Appreciable changes in the profiles, reflecting changes in the concentration of a number of metabolites, were detected and discussed in terms of chemical and enzymatic reactions for both blood and urine samples. Appropriate procedures for blood derivatives collection and urine preservation/storage that allow maintaining as much as possible the original metabolic profile of the fresh samples emerge, and are proposed as SOPs for biobanking.

  18. Standard operating procedures for pre-analytical handling of blood and urine for metabolomic studies and biobanks

    Energy Technology Data Exchange (ETDEWEB)

    Bernini, Patrizia; Bertini, Ivano, E-mail: bertini@cerm.unifi.it; Luchinat, Claudio [University of Florence, Magnetic Resonance Center (CERM) (Italy); Nincheri, Paola; Staderini, Samuele [FiorGen Foundation (Italy); Turano, Paola [University of Florence, Magnetic Resonance Center (CERM) (Italy)

    2011-04-15

    {sup 1}H NMR metabolic profiling of urine, serum and plasma has been used to monitor the impact of the pre-analytical steps on the sample quality and stability in order to propose standard operating procedures (SOPs) for deposition in biobanks. We analyzed the quality of serum and plasma samples as a function of the elapsed time (t = 0-4 h) between blood collection and processing and of the time from processing to freezing (up to 24 h). The stability of the urine metabolic profile over time (up to 24 h) at various storage temperatures was monitored as a function of the different pre-analytical treatments like pre-storage centrifugation, filtration, and addition of the bacteriostatic preservative sodium azide. Appreciable changes in the profiles, reflecting changes in the concentration of a number of metabolites, were detected and discussed in terms of chemical and enzymatic reactions for both blood and urine samples. Appropriate procedures for blood derivatives collection and urine preservation/storage that allow maintaining as much as possible the original metabolic profile of the fresh samples emerge, and are proposed as SOPs for biobanking.

  19. Revisiting olfactory classical conditioning of the proboscis extension response in honey bees: a step toward standardized procedures.

    Science.gov (United States)

    Matsumoto, Yukihisa; Menzel, Randolf; Sandoz, Jean-Christophe; Giurfa, Martin

    2012-10-15

    The honey bee Apis mellifera has emerged as a robust and influential model for the study of classical conditioning thanks to the existence of a powerful Pavlovian conditioning protocol, the olfactory conditioning of the proboscis extension response (PER). In 2011, the olfactory PER conditioning protocol celebrated its 50 years since it was first introduced by Kimihisa Takeda in 1961. In this protocol, individually harnessed honey bees are trained to associate an odor with sucrose solution. The resulting olfactory learning is fast and induces robust olfactory memories that have been characterized at the behavioral, neuronal and molecular levels. Despite the success of this protocol for studying the bases of learning and memory at these different levels, innumerable procedural variants have arisen throughout the years, which render comparative analyses of behavioral performances difficult. Moreover, because even slight variations in conditioning procedures may introduce significant differences in acquisition and retention performances, we revisit olfactory PER conditioning and define here a standardized framework for experiments using this behavioral protocol. To this end, we present and discuss all the methodological steps and details necessary for successful implementation of olfactory PER conditioning. Copyright © 2012 Elsevier B.V. All rights reserved.

  20. Quality Procedures in the European Higher Education Area and Beyond--Second ENQA Survey. ENQA Occasional Papers 14

    Science.gov (United States)

    Costes, Nathalie; Crozier, Fiona; Cullen, Peter; Grifoll, Josep; Harris, Nick; Helle, Emmi; Hopbach, Achim; Kekalainen, Helka; Knezevic, Bozana; Sits, Tanel; Sohm, Kurt

    2008-01-01

    Quality assurance for higher education in Europe has developed significantly since 2002, and has increasingly influenced, and been influenced by, the Bologna Process. A major step in the Bologna Process was taken at the ministerial meeting in Bergen in May 2005, with the adoption of the Standards and Guidelines for Quality Assurance in the…

  1. Standard Operating Procedure

    National Research Council Canada - National Science Library

    1997-01-01

    ...) plastic collection bag system. Red blood cell concentrates stored at 4 C in the 800 ml primary plastic collection bag can be biochemically modified to increase the red cell 2,3 DPG and ATP levels...

  2. Design reinforced concrete structures: Differences in procedure, formula, and results between Eurocode 2 and British Standard 8110

    Science.gov (United States)

    Rahim, Mustaqqim Abdul; Ying, Lum Chui; Shahidan, Shahiron; Ghazaly, Zuhayr Md.; Anudai, Shamilah; Bawadi, Nor Faizah; Isa, Nur Fitriah; Hassan, Zulkarnain; Habulat, Afifuddin; Ismail, Zul-Atfi

    2017-09-01

    This research is mainly about comparisons of reinforced concrete structure design based on Eurocode 2 and British Standard 8110. The reinforcement concrete element is designed by referring Eurocode 2 (EN1992-1-1) and British Standard 8110 (BS8110-1:1997) for comparing purpose. The work examples of the structural elements has been done in this research to obtain the area of reinforcement required. The differences in procedure, formula and result of area of steel required for the elements based on both of the codes are compared and tabulated. In this research, there are five part of reinforced concrete structure elements are designed which are continuous beams, one way slabs, braced and short column, pile cap, and cantilever retaining wall. From the result acquired, it shows that area of reinforcement required based on EC 2 is lesser than BS 8110 and the dimension required based on BS8110 is larger than EC 2. Meanwhile, the design based on Eurocode 2 came out with more economical structural elements compare to BS 8110 as lesser steel and concrete volume required.

  3. Assessment of the standard forensic procedure for the evaluation of psychological injury in intimate-partner violence.

    Science.gov (United States)

    Fariña, Francisca; Arce, Ramón; Vilariño, Manuel; Novo, Mercedes

    2014-01-01

    In judicial terms, a victim refers to any person who has suffered injury arising from an action or omission of an action that constitutes an offence, and the burden of proof lies with the prosecution. A review of Spanish judicial judgements underscored that the lack of evidence of psychological injury in cases of intimate-partner violence (IPV) accounted for approximately 40% of acquittals. Thus, the Spanish standard of proof for the forensic evaluation of psychological injury i.e., the MMPI-2 and the unstructured interview were assessed in order to determine if they met the statutory requirement for the assessment of psychological injury and the differential diagnosis of feigning. The results of the comparison of 51 women victims of IPV with firm convictions against their aggressors, and 54 women mock victims of IPV showed that the F, K, Fb, Fp and Ds scales, and the F-K index discriminated significantly and with medium and large effect sizes, between adjudicated and mock victims. However, the results did not provide a valid decision criterion for forensic settings i.e., false negatives (identifying feigner as honest protocols) were not classified correctly. In conclusion, the standard forensic procedure for the evaluation of psychological injury in cases of IPV did not constitute valid proof for judges who acquitted defendants on the grounds of not proven due to the lack of evidence of psychological injury.

  4. Drawing the Line: Same-sex adoption and the jurisprudence of the ECtHR on the application of the “European consensus” standard under Article 14

    Directory of Open Access Journals (Sweden)

    Junko Nozawa

    2013-07-01

    Full Text Available One of the main criteria that the European Court of Human Rights uses in determining the parameters of the margin of appreciation has been to find a consensus among the state parties to the Convention as to the definition or interpretation of a specific right.  The way the Court has implemented the methodology of finding a "European consensus" of the discriminatory practice of states under Article 14 has been problematic. Firstly, it is unclear when the Court takes into consideration the practice of member states of the European Council. Secondly, it is unclear how it defines the comparative group and the threshold necessary in defining a consensus. This note looks at the application of the Court of this standard in cases concerning same-sex adoption in light of its most recent decision in X. and Others v. Austria (2013. It is argued that the application of the standard in practice has yielded variable jurisprudence, is inconsistently applied, and risks further fragmenting Contracting States' obligations under the Convention. In using the consensus standard as an interpretive comparative tool, the Court should allow a narrow margin of appreciation only where there is substantial consensus on an issue. It is the author's position that its negative iteration, or the notion that a lack of consensus should yield a wide margin, should not be maintained, as this approach risks further deteriorating the protection of fundamental rights.

  5. External quality assurance programs as a tool for verifying standardization of measurement procedures: Pilot collaboration in Europe.

    Science.gov (United States)

    Perich, C; Ricós, C; Alvarez, V; Biosca, C; Boned, B; Cava, F; Doménech, M V; Fernández-Calle, P; Fernández-Fernández, P; García-Lario, J V; Minchinela, J; Simón, M; Jansen, R

    2014-05-15

    Current external quality assurance schemes have been classified into six categories, according to their ability to verify the degree of standardization of the participating measurement procedures. SKML (Netherlands) is a Category 1 EQA scheme (commutable EQA materials with values assigned by reference methods), whereas SEQC (Spain) is a Category 5 scheme (replicate analyses of non-commutable materials with no values assigned by reference methods). The results obtained by a group of Spanish laboratories participating in a pilot study organized by SKML are examined, with the aim of pointing out the improvements over our current scheme that a Category 1 program could provide. Imprecision and bias are calculated for each analyte and laboratory, and compared with quality specifications derived from biological variation. Of the 26 analytes studied, 9 had results comparable with those from reference methods, and 10 analytes did not have comparable results. The remaining 7 analytes measured did not have available reference method values, and in these cases, comparison with the peer group showed comparable results. The reasons for disagreement in the second group can be summarized as: use of non-standard methods (IFCC without exogenous pyridoxal phosphate for AST and ALT, Jaffé kinetic at low-normal creatinine concentrations and with eGFR); non-commutability of the reference material used to assign values to the routine calibrator (calcium, magnesium and sodium); use of reference materials without established commutability instead of reference methods for AST and GGT, and lack of a systematic effort by manufacturers to harmonize results. Results obtained in this work demonstrate the important role of external quality assurance programs using commutable materials with values assigned by reference methods to correctly monitor the standardization of laboratory tests with consequent minimization of risk to patients. Copyright © 2013 Elsevier B.V. All rights reserved.

  6. Feasibility of dietary assessment methods, other tools and procedures for a pan-European food consumption survey among infants, toddlers and children.

    Science.gov (United States)

    Ocké, Marga; Brants, Henny; Dofkova, Marcela; Freisling, Heinz; van Rossum, Caroline; Ruprich, Jiri; Slimani, Nadia; Temme, Elisabeth; Trolle, Ellen; Vandevijvere, Stefanie; Huybrechts, Inge; de Boer, Evelien

    2015-08-01

    To test the feasibility of tools and procedures for a pan-European food consumption survey among children 0-10 years and to recommend one of two tested dietary assessment methods. Two pilot studies including 378 children were conducted in Belgium and the Czech Republic in the Pilot studies for Assessment of Nutrient intake and food Consumption among Kids in Europe. One protocol included a 3-day food diary which was checked with a parent, and data were entered afterwards using EPIC-Soft. The alternative protocol consisted of two non-consecutive 1-day food diaries followed by EPIC-Soft completion interviews. Both protocols included general and food propensity questionnaires and anthropometric measurements. The protocols were compared using evaluation questionnaires among the participating parents and study personnel. The parents found the questionnaires and instructions for filling in the food diaries understandable. Food description and food quantification was evaluated as problematic by 29 and 15% of the participants for the 3-day diaries versus 15 and 12% for the 1-day diaries. The protocol with 1-day food diaries was evaluated as less burdensome by the parents and logistically more challenging by the interviewers. Both dietary assessment methods with related tools and administration protocols were evaluated as feasible. The administration protocol with two 1-day food diaries with completion interviews offers more advantages for the future pan-European survey in children 0-10 years. The positive evaluation of feasibility of tools and materials is an important step towards harmonised food consumption data at European level among the younger age groups.

  7. Comparison of Test Procedures and Energy Efficiency Criteria in Selected International Standards & Labeling Programs for Copy Machines, External Power Supplies, LED Displays, Residential Gas Cooktops and Televisions

    Energy Technology Data Exchange (ETDEWEB)

    Zheng, Nina [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Zhou, Nan [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Fridley, David [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

    2012-03-01

    This report presents a technical review of international minimum energy performance standards (MEPS), voluntary and mandatory energy efficiency labels and test procedures for five products being considered for new or revised MEPS in China: copy machines, external power supply, LED displays, residential gas cooktops and flat-screen televisions. For each product, an overview of the scope of existing international standards and labeling programs, energy values and energy performance metrics and description and detailed summary table of criteria and procedures in major test standards are presented.

  8. The Mandatory Introduction of IFRS as a Single Accounting Standard in the European Union and the Effect on Earnings Management

    NARCIS (Netherlands)

    M.B.W. Lippens (Mark)

    2010-01-01

    textabstractExecutive summary In this study, it was investigated whether the mandatory adoption of IFRS from 1 January 2005 by all listed companies in the European Union led to significantly lower levels of earnings management. I found that, despite the stricter character of IFRS compared to

  9. Radiation protection in odontology: French regulation and new European standards; La radioprotection en odontologie: reglementation francaise et nouvelles normes europeennes

    Energy Technology Data Exchange (ETDEWEB)

    Foucart, J.M

    2004-07-01

    This a point on the regulatory evolutions in the field of radiation protection in the daily practice of odontology, consecutive to the transposition in French law of European directives. This work proposes practical cards to manage installation in radiodiagnosis in order to protect professional personnel and patients. (N.C.)

  10. The role of European Federation of Clinical Chemistry and Laboratory Medicine Working Group for Preanalytical Phase in standardization and harmonization of the preanalytical phase in Europe

    DEFF Research Database (Denmark)

    Cornes, Michael P; Church, Stephen; van Dongen-Lases, Edmée

    2016-01-01

    Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry and Labor......Patient safety is a leading challenge in healthcare and from the laboratory perspective it is now well established that preanalytical errors are the major contributor to the overall rate of diagnostic and therapeutic errors. To address this, the European Federation of Clinical Chemistry...... and Laboratory Medicine Working Group for Preanalytical Phase (EFLM WG-PRE) was established to lead in standardization and harmonization of preanalytical policies and practices at a European level. One of the key activities of the WG-PRE is the organization of the biennial EFLM-BD conference on the preanalytical...... summarises the work that has and will be done in these areas. The goal of this initiative is to ensure the EFLM WG-PRE produces work that meets the needs of the European laboratory medicine community. Progress made in the identified areas will be updated at the next preanalytical phase conference and show...

  11. Sound exposure changes European seabass behaviour in a large outdoor floating pen: Effects of temporal structure and a ramp-up procedure.

    Science.gov (United States)

    Neo, Y Y; Hubert, J; Bolle, L; Winter, H V; Ten Cate, C; Slabbekoorn, H

    2016-07-01

    Underwater sound from human activities may affect fish behaviour negatively and threaten the stability of fish stocks. However, some fundamental understanding is still lacking for adequate impact assessments and potential mitigation strategies. For example, little is known about the potential contribution of the temporal features of sound, the efficacy of ramp-up procedures, and the generalisability of results from indoor studies to the outdoors. Using a semi-natural set-up, we exposed European seabass in an outdoor pen to four treatments: 1) continuous sound, 2) intermittent sound with a regular repetition interval, 3) irregular repetition intervals and 4) a regular repetition interval with amplitude 'ramp-up'. Upon sound exposure, the fish increased swimming speed and depth, and swam away from the sound source. The behavioural readouts were generally consistent with earlier indoor experiments, but the changes and recovery were more variable and were not significantly influenced by sound intermittency and interval regularity. In addition, the 'ramp-up' procedure elicited immediate diving response, similar to the onset of treatment without a 'ramp-up', but the fish did not swim away from the sound source as expected. Our findings suggest that while sound impact studies outdoors increase ecological and behavioural validity, the inherently higher variability also reduces resolution that may be counteracted by increasing sample size or looking into different individual coping styles. Our results also question the efficacy of 'ramp-up' in deterring marine animals, which warrants more investigation. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. LEGAL EDUCATION OF PHARMACISTS IN A CONTEXT OF SOCIETY DEMOCRATIZATION AND THE EUROPEAN STANDARDS OF EDUCATION IN UKRAINE

    Directory of Open Access Journals (Sweden)

    I. M. Alieksieieva

    2015-04-01

    , spiritual, humanitarian, professional, etc. and active influence on social and public processes. ConclusIons: 1. Formation of Ukraine as a democratic, legal and social state regulated by the Constitution - the Basic Law and legislation on European integration, is therefore binding. Fundamental to achieve these ideals is the formation of personality with high level of legal awareness and legal culture. It can only be resolved in the process of focused, unified, systematic and evidence-based legal education, combined with a legal training. 2. The general motivation of a citizen to legal education caused by the following factors: growing as more and more political and economic international integration; rather complex economic and social relations at the national level; requirements of state vocational qualification standards; formation needs and ability to actively protect the established interests of law and the rights of both their own and other participants in public relations. 3. The major attention need legal education students. This is due to the following factors: 1 The specified category of youth is relatively independent, rather numerous social actors, carrier group sense of justice; 2 justice students largely determine the mode and the state of law and order in society; 3 students, opposed to other social groups, most masters, professions and specialties are needed in terms of transformation of society; 4 It is the main carrier of intellectual and physical potential of the nation and the only source of replenishment of highly qualified human resources of the state.4. Pharmacy legislation, Pharmacy Education, Pharmacists

  13. Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

    Science.gov (United States)

    Ravid, Rivka

    2008-06-01

    The use of human biological specimens in scientific research is the focus of current international public and professional concern and a major issue in bioethics in general. Brain/Tissue/Bio banks (BTB-banks) are a rapid developing sector; each of these banks acts locally as a steering unit for the establishment of the local Standard Operating Procedures (SOPs) and the legal regulations and ethical guidelines to be followed in the procurement and dissemination of research specimens. An appropriat Code of Conduct is crucial to a successful operation of the banks and the research application they handle. What are we still missing ? (1) Adequate funding for research BTB-banks. (2) Standard evaluation protocls for audit of BTB-bank performance. (3) Internationally accepted SOP's which will facilitate exchange and sharing of specimens and data with the scientific community. (4) Internationally accepted Code of Conduct. In the present paper we review the most pressing organizational, methodological, medico-legal and ethical issues involved in BTB-banking; funding, auditing, procurement, management/handling, dissemination and sharing of specimens, confidentiality and data protection, genetic testing, "financial gain" and safety measures. Taking into consideration the huge variety of the specimens stored in different repositories and the enormous differences in medico-legal systems and ethics regulations in different countries it is strongly recommend that the health-care systems and institutions who host BTB-Banks will put more efforts in getting adequate funding for the infrastructure and daily activities. The BTB-banks should define evaluation protocols, SOPs and their Code of Conduct. This in turn will enable the banks to share the collected specimens and data with the largest possible number of researchers and aim at a maximal scientific spin-off and advance in public health research.

  14. Enumeration of heterotrophs, fecal coliforms and Escherichia coli in water: comparison of 3M Petrifilm plates with standard plating procedures.

    Science.gov (United States)

    Schraft, H; Watterworth, L A

    2005-03-01

    A total of 177 naturally contaminated water samples were analyzed by membrane filtration according to the Standard Methods for the Examination of Water and Wastewater published by the American Public Health Association. Filters were incubated in parallel on mHPC-agar and 3M Petrifilm Aerobic Count Plates (Petrifilm AC plates) for heterotrophic counts. Fecal coliforms and Escherichia coli were enumerated on mFC-agar and 3M Petrifilm E. coli/Coliform Count Plates (Petrifilm EC plates). Typical colonies on each media type were confirmed following standard procedures. Heterotrophic counts were between 10(3) and 10(4) CFU/mL and the average log10 counts obtained on Petrifilm AC plates were about two-fold lower than on mHPC-agar. Counts for fecal coliforms and E. coli were between 10(2) and 10(3) CFU/mL. Average log10 counts for confirmed fecal coliforms obtained on Petrifilm EC plates were slightly lower than on mFC agar with a correlation coefficient of 0.949. The average log10 counts for confirmed E. coli on Petrifilm EC plates and on mFC agar were statistically not different (P=0.126) with a correlation coefficient of 0.879. Specificity of Petrifilm EC plates and mFC agar was evaluated by comparing typical colony counts with confirmed counts. On mFC agar, counts for typical colonies were by 2 log10 CFU higher than the actual confirmed counts. In contrast, on Petrifilm EC plates typical colony counts were almost identical to confirmed colony counts for both fecal coliforms and E. coli. This comparison illustrates the high specificity of Petrifilm EC plates for enumeration of both fecal coliforms and E. coli in water.

  15. Standard Operating Procedures, ethical and legal regulations in BTB (Brain/Tissue/Bio) banking: what is still missing?

    Science.gov (United States)

    Ravid, Rivka

    2008-09-01

    The use of human biological specimens in scientific research is the focus of current international public and professional concern and a major issue in bioethics in general. Brain/Tissue/Bio banks (BTB-banks) are a rapid developing sector; each of these banks acts locally as a steering unit for the establishment of the local Standard Operating Procedures (SOPs) and the legal regulations and ethical guidelines to be followed in the procurement and dissemination of research specimens. An appropriat Code of Conduct is crucial to a successful operation of the banks and the research application they handle. What are we still missing ? (1) Adequate funding for research BTB-banks. (2) Standard evaluation protocls for audit of BTB-bank performance. (3) Internationally accepted SOP's which will facilitate exchange and sharing of specimens and data with the scientific community. (4) Internationally accepted Code of Conduct. In the present paper we review the most pressing organizational, methodological, medico-legal and ethical issues involved in BTB-banking; funding, auditing, procurement, management/handling, dissemination and sharing of specimens, confidentiality and data protection, genetic testing, "financial gain" and safety measures. Taking into consideration the huge variety of the specimens stored in different repositories and the enormous differences in medico-legal systems and ethics regulations in different countries it is strongly recommend that the health-care systems and institutions who host BTB-Banks will put more efforts in getting adequate funding for the infrastructure and daily activities. The BTB-banks should define evaluation protocols, SOPs and their Code of Conduct. This in turn will enable the banks to share the collected specimens and data with the largest possible number of researchers and aim at a maximal scientific spin-off and advance in public health research.

  16. Comparison of ultraviolet A light protection standards in the United States and European Union through in vitro measurements of commercially available sunscreens.

    Science.gov (United States)

    Wang, Steven Q; Xu, Haoming; Stanfield, Joseph W; Osterwalder, Uli; Herzog, Bernd

    2017-07-01

    The importance of adequate ultraviolet A light (UVA) protection has become apparent in recent years. The United States and Europe have different standards for assessing UVA protection in sunscreen products. We sought to measure the in vitro critical wavelength (CW) and UVA protection factor (PF) of commercially available US sunscreen products and see if they meet standards set by the United States and the European Union. Twenty sunscreen products with sun protection factors ranging from 15 to 100+ were analyzed. Two in vitro UVA protection tests were conducted in accordance with the 2011 US Food and Drug Administration final rule and the 2012 International Organization for Standardization method for sunscreen effectiveness testing. The CW of the tested sunscreens ranged from 367 to 382 nm, and the UVA PF of the products ranged from 6.1 to 32. Nineteen of 20 sunscreens (95%) met the US requirement of CW >370 nm. Eleven of 20 sunscreens (55%) met the EU desired ratio of UVA PF/SPF > 1:3. The study only evaluated a small number of sunscreen products. The majority of tested sunscreens offered adequate UVA protection according to US Food and Drug Administration guidelines for broad-spectrum status, but almost half of the sunscreens tested did not pass standards set in the European Union. Copyright © 2017. Published by Elsevier Inc.

  17. Calibration of photon and beta ray sources used in brachytherapy. Guidelines on standardized procedures at Secondary Standards Dosimetry Laboratories (SSDLs) and hospitals

    International Nuclear Information System (INIS)

    2002-03-01

    It has generally been recognized that international harmonization in radiotherapy dosimetry is essential. Consequently, the IAEA has given much effort to this, for example by publishing a number of reports in the Technical Reports Series (TRS) for external beam dosimetry, most notably TRS-277 and more recently TRS-398. Both of these reports describe in detail the steps to be taken for absorbed dose determination in water and they are often referred to as 'dosimetry protocols'. Similar to TRS-277, it is expected that TRS-398 will be adopted or used as a model by a large number of countries as their national protocol. In 1996, the IAEA established a calibration service for low dose rate (LDR) 137 Cs brachytherapy sources, which is the most widely used source for treatment of gynecological cancer. To further enhance harmonization in brachytherapy dosimetry, the IAEA published in 1999 IAEA-TECDOC-1079 entitled 'Calibration of Brachytherapy Sources. Guidelines on Standardized Procedures for the Calibration of Brachytherapy Sources at Secondary Standard Dosimetry Laboratories (SSDLs) and Hospitals'. The report was well received and was distributed in a large number of copies to the members of the IAEA/WHO network of SSDLs and to medical physicists working with brachytherapy. The present report is an update of the aforementioned TECDOC. Whereas TECDOC-1079 described methods for calibrating brachytherapy sources with photon energies at or above those of 192 Ir, the current report has a wider scope in that it deals with standardization of calibration of all the most commonly used brachytherapy sources, including both photon and beta emitting sources. The latter sources have been in use for a few decades already, but their calibration methods have been unclear. Methods are also described for calibrating sources used in the rapidly growing field of cardiovascular angioplasty. In this application, irradiation of the vessel wall is done in an attempt to prevent restenosis after

  18. Evaluasi Penerapan Standard Operating Procedure-Good Agriculture Practice (SOP-GAP pada Usahatani Padi Organik di Kabupaten Bantul

    Directory of Open Access Journals (Sweden)

    Sriyadi Sriyadi

    2016-02-01

    Full Text Available Food security has meaning not only the availability of adequate food, but also providing security for producers and consumers and ensuring environmental sustainability for sustainable production. Organic farming systems are expected to solve the problem for realizing food security and enhancement of people's welfare. The results of research indicated that, (1 The implementation level of Standard Operating Procedure-Good Agriculture Practice (SOP-GAP of Organic Rice Farming in Bantul district was quite high, (2 The implementation level of SOP-GAP of Organic Rice Farming related to the availability of capital, the selling price and the purchase price of inputs (seeds and fertilizers, (3 The level of the farmer's decision related to the implementation level of SOP-GAP of organic rice farming, and (4 development of organic rice farming required availability of sufficient capital. In this regard the government, particularly the agriculture authority and food security agency need to disburse or facilitate capital for farmers in revolving as well as low interest loans.

  19. Standard operating procedure for air quality stationary source management at Air Force installations in the Air Force Materiel Command

    Energy Technology Data Exchange (ETDEWEB)

    Powell, C.M.; Ryckman, S.J. [Headquarters Air Force Materiel Command, Wright-Patterson AFB, OH (United States). Environmental Compliance Branch

    1997-12-31

    To sustain compliance and avoid future enforcement actions associated with air quality stationary sources and to provide installation commanders with a certification process for Title V permitting, and Air Force Materiel Command (AFMC) Standard Operating Procedure (SOP) for Stationary Source Management has been developed. The SOP consists of two major sections: Stationary Source Planning and Administration, and Stationary Source Operations These two main sections are further subdivided into twelve subsections which delineate requirements (e.g. maintaining inventories, applying for and maintaining permits, keeping records, reporting and certifying compliance) and assign ownership of processes and responsibilities (e.g. appointing a manager/alternate for each identified stationary air source). In addition, the SOP suggests training that should be provided from operator to commander levels to ensure that all personnel involved with a stationary air source are aware of their responsibilities. Implementation of the SOP should provide for the essential control necessary for installation commanders to eliminate stationary air source non-compliance and to certify compliance in accordance with the Title V Operating Permit requirements. This paper will discuss: the background and purpose for the SOPs content, the twelve subsections of the SOP, the success of implementation at various installations, the relevance or the recommended training, the success of negotiating with various labor unions for SOP implementation and the success of the SOP in reference to its intended purpose.

  20. (60)Co in cast steel matrix: A European interlaboratory comparison for the characterisation of new activity standards for calibration of gamma-ray spectrometers in metallurgy.

    Science.gov (United States)

    Tzika, Faidra; Burda, Oleksiy; Hult, Mikael; Arnold, Dirk; Marroyo, Belén Caro; Dryák, Pavel; Fazio, Aldo; Ferreux, Laurent; García-Toraño, Eduardo; Javornik, Andrej; Klemola, Seppo; Luca, Aurelian; Moser, Hannah; Nečemer, Marijan; Peyrés, Virginia; Reis, Mario; Silva, Lidia; Šolc, Jaroslav; Svec, Anton; Tyminski, Zbigniew; Vodenik, Branko; Wätjen, Uwe

    2016-08-01

    Two series of activity standards of (60)Co in cast steel matrix, developed for the calibration of gamma-ray spectrometry systems in the metallurgical sector, were characterised using a European interlaboratory comparison among twelve National Metrology Institutes and one international organisation. The first standard, consisting of 14 disc shaped samples, was cast from steel contaminated during production ("originally"), and the second, consisting of 15 similar discs, from artificially-contaminated ("spiked") steel. The reference activity concentrations of (60)Co in the cast steel standards were (1.077±0.019) Bqg(-1) on 1 January 2013 12h00 UT and (1.483±0.022) Bqg(-1) on 1 June 2013 12h00 UT, respectively. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  1. Test Standard Revision Update: JESD57, "Procedures for the Measurement of Single-Event Effects in Semiconductor Devices from Heavy-Ion Irradiation"

    Science.gov (United States)

    Lauenstein, Jean-Marie

    2015-01-01

    The JEDEC JESD57 test standard, Procedures for the Measurement of Single-Event Effects in Semiconductor Devices from Heavy-Ion Irradiation, is undergoing its first revision since 1996. In this talk, we place this test standard into context with other relevant radiation test standards to show its importance for single-event effect radiation testing for space applications. We show the range of industry, government, and end-user party involvement in the revision. Finally, we highlight some of the key changes being made and discuss the trade-space in which setting standards must be made to be both useful and broadly adopted.

  2. Recommendations and Strategies for the Establishment of a Guideline for Monument Documentation Harmonized with the Existing European Standards and Codes

    Directory of Open Access Journals (Sweden)

    Anastasia Kioussi

    2011-12-01

    Full Text Available Information on current state of immovable cultural heritage is important for specifying measures necessary to preserve the heritage in an appropriate condition and ensure that the maintenance required to keep it at this level is well defined. In this framework, EU-CHIC project aims to set-up a system introducing a concept of the “Cultural Heritage Identity Card”, which will develop into a systematic collection and storage of data on immovable heritage objects across European and neighboring countries. This work supports sustainable maintenance, preservation and revitalization of historic sites and monuments. This is achieved through the development of a guideline for the assessment of efficient documentation systems that identify the parameters needed for the characterisation of the preservation state of a monument and its possible alterations during its entire lifetime. In order to develop and test the recommendations for efficient compilation of the data pertinent to each monument under observation, the development of criteria, indicators and protocols as part of a common methodology that encourages the exchange of document between European countries is initiated. The criteria encompass all potential factors affecting the building structure, the non-structural elements, the architectural value and any other aspects ranging from the functionality of the monument/building, to its historic value. This has been achieved through an integrated survey of existing documentation protocols in the field of cultural heritage protection, and through implementation of recommendations about criteria for harmonizing these protocols, both which provide a new documentation methodology. This new methodology is an upgrade of current documentation methodologies, and responds to criteria and indicators for risk assessment and the technology state of diagnostics and data management. A guideline will provide the essential document for further development of

  3. Final Rule for Control of Air Pollution from Aircraft and Aircraft Engines: Emission Standards and Test Procedures

    Science.gov (United States)

    EPA is amending the existing emission standards for oxides of nitrogen (NOx) for new commercial aircraft engines. These standards are equivalent to the NOx emission standards of the United Nations International Civil Aviation Organization (ICAO).

  4. Direct Final Rule for Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

    Science.gov (United States)

    This rule will adopt the current voluntary NOx and CO emissions standards of the United Nations International Civil Aviation Organization (ICAO), bringing the United States aircraft standards into alignment with the international standards.

  5. The impact of European standards concerning radiation sterilization on the quality assurance of medical products in Poland

    International Nuclear Information System (INIS)

    Kaluska, I.; Zimek, Z.

    1999-01-01

    The ISO 11137 and EN 552 standards were issued in the mid-90's. These documents have been devoted to the requirements regarding the sterile medical devices offered on the market. The implementation of those standards by Polish manufacturers of medical devices is discussed in this paper. The currently introduced national regulations effectively stimulated this process. The activities of the Institute of Nuclear Chemistry and Technology (INCT) in the field of radiation sterilization standardization and its radiation sterilization commercial service are described. (author)

  6. Comparison of IEEE383-2003 and IEC60505-2004 standards for harmonization of environmental qualification procedure of electric cable

    International Nuclear Information System (INIS)

    Kim, Jong Seog; Jeong, Sun Chul; Park, Kyung Heum; Jang, Kyung Nam

    2010-01-01

    Needs for harmonization of international equipment qualification(EQ) standards have been raised several years due to purchasing problem of nuclear equipment supplied from abroad country. To meet the regulatory requirement of domestic nuclear power plant, manufacturers have to qualify their equipment in accordance with each standard such as IEEE, IEC and RCC-E. Double qualification increase the equipment cost, which result in high construction cost. Even the unification of each standard have been discussed several years, we have got the long way to go yet. Comparison and harmonization of each international standard will give help to purchase the equipment qualified by not endorsed standard. Environmental qualification, seismic qualification and EMI/EMC qualification are major targets for harmonization. Since concern about cable qualification of 60 years life has been raised recently, harmonization of cable qualification standard also needs to be discussed. KEPRI launched a project for harmonization of EQ relative standards such as IEEE, IEC and RCC-E. A study for harmonization of IEEE323 and IEC60780 is known in progress by IEEE committee. In this paper, harmonization of international standards for cable qualification will be discussed. IEEE383 standard is qualification standard for electric cable broadly used in Asian pacific area while IEC60505 is mostly used in European area. Since these two standards have different requirements for environmental qualification of cable, problem can be happened in the plant site when they purchase cable qualified by not endorsed standard. IEEE383-2003 and IEC60505-2004 is the latest version of each standard. Comparison results and recommendations for harmonization of these two standards are introduced herein

  7. Specific safety measures for emergency lanes and shoulders of motorways : a proposal for motorways' authorities in the framework of the European research project Safety Standards for Road Design and Redesign SAFESTAR, Workpackage 1.1.

    NARCIS (Netherlands)

    Braimaister, L.

    1999-01-01

    This workpackage is one of seven workpackages of the European SAFESTAR project, launched by DG VII. Directing on safety standards and recommendations for the Trans-European Roadway Network (TERN), the workpackage considered safety measures on emergency lanes (stopping strips), which are inherent

  8. Reference standard space hippocampus labels according to the European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative harmonized protocol: Utility in automated volumetry.

    Science.gov (United States)

    Wolf, Dominik; Bocchetta, Martina; Preboske, Gregory M; Boccardi, Marina; Grothe, Michel J

    2017-08-01

    A harmonized protocol (HarP) for manual hippocampal segmentation on magnetic resonance imaging (MRI) has recently been developed by an international European Alzheimer's Disease Consortium-Alzheimer's Disease Neuroimaging Initiative project. We aimed at providing consensual certified HarP hippocampal labels in Montreal Neurological Institute (MNI) standard space to serve as reference in automated image analyses. Manual HarP tracings on the high-resolution MNI152 standard space template of four expert certified HarP tracers were combined to obtain consensual bilateral hippocampus labels. Utility and validity of these reference labels is demonstrated in a simple atlas-based morphometry approach for automated calculation of HarP-compliant hippocampal volumes within SPM software. Individual tracings showed very high agreement among the four expert tracers (pairwise Jaccard indices 0.82-0.87). Automatically calculated hippocampal volumes were highly correlated (r L/R  = 0.89/0.91) with gold standard volumes in the HarP benchmark data set (N = 135 MRIs), with a mean volume difference of 9% (standard deviation 7%). The consensual HarP hippocampus labels in the MNI152 template can serve as a reference standard for automated image analyses involving MNI standard space normalization. Copyright © 2017 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

  9. Lawyer of defendant and his role in the criminal process from the viewpoint of the European Convention on Human Rights and the Albanian criminal procedural legislation

    Directory of Open Access Journals (Sweden)

    Klodjan Skenderaj

    2014-01-01

    Full Text Available A guarantee for real ensuring of defendant’s rights is the qualified legal assistance by the side of the lawyer, chosen or assigned by the proceeding body. Providing legal protection to defendants was an important achievement in the long and difficult efforts to democratize the criminal proceedings. It was initially achieved in developed countries which promulgated the fundamental rights and freedoms and on this basis the major laws of activity of justice’s bodies were enforced. The role of lawyer in the criminal proceeding gradually increased and became an important factor in the fight against violations of law and injustice. The lawyer became a respected procedural figure, standing in front of prosecution, as the opposing party able to develop a cross-examination and to influence in a fair solution of case. However in practice, it is not rare the violation of rights of defendants by proceeding organs. So, it is right to make this question: What will be done with their rights and how will they be protected? In practice there were different opinions in terms of guaranteeing the rights of these defendants and how far the rights of lawyers of the defendants are extended. This is the reason why this paper will bring in attention the position, procedural guarantees of lawyers, the actions that can take and the exercise of their main rights in defending the interest of defendant, taking into account the main phases of criminal proceedings. Special attention will be devoted to case law of European Court of Human Rights (ECHR in terms of guaranteeing the rights of defendants, the orientations of the Albanian Constitutional Court and that of Supreme Court. At the end, this paper will reach in some conclusions through which proposals and amendments will be made to the code of criminal procedure, starting from the principle that the rights and procedural guarantees of defendants should be guaranteed at the maximum, because it’s the only way to

  10. Comparison of European codes and standards on the welding of LMFBR components and proposals for their harmonization

    International Nuclear Information System (INIS)

    Koehler, S.

    1992-01-01

    A comparative study has been conducted, within the framework of the exercises of comparisons of specifications and standards for fast reactors in the following specialized fields: - welding supervisor, welder; - welder's tests; -production test specimens of welds; - measures to prevent mistakes with weld material. The relevant specifications were forwarded by the national delegations: Germany, France, Italy and United Kingdom. The comparison has been presented in tabular form where rules for a particular sub-group of specialized field are laid down in the standards of at least two Member States. In each case, the conclusions and requirements set out in the national standards have been compared in relation to a specific comparison criterion. The quantitative comparisons of the requirements laid down in the individual national standards are assessed from the following standpoints: a) points of agreement between the regulations in the standards of all four Member states (Germany, France, United Kingdom and Italy); b) significant differences between the regulations. 13 tabs

  11. Development and operation of a quality assurance system for deviations from standard operating procedures in a clinical cell therapy laboratory.

    Science.gov (United States)

    McKenna, D; Kadidlo, D; Sumstad, D; McCullough, J

    2003-01-01

    Errors and accidents, or deviations from standard operating procedures, other policy, or regulations must be documented and reviewed, with corrective actions taken to assure quality performance in a cellular therapy laboratory. Though expectations and guidance for deviation management exist, a description of the framework for the development of such a program is lacking in the literature. Here we describe our deviation management program, which uses a Microsoft Access database and Microsoft Excel to analyze deviations and notable events, facilitating quality assurance (QA) functions and ongoing process improvement. Data is stored in a Microsoft Access database with an assignment to one of six deviation type categories. Deviation events are evaluated for potential impact on patient and product, and impact scores for each are determined using a 0- 4 grading scale. An immediate investigation occurs, and corrective actions are taken to prevent future similar events from taking place. Additionally, deviation data is collectively analyzed on a quarterly basis using Microsoft Excel, to identify recurring events or developing trends. Between January 1, 2001 and December 31, 2001 over 2500 products were processed at our laboratory. During this time period, 335 deviations and notable events occurred, affecting 385 products and/or patients. Deviations within the 'technical error' category were most common (37%). Thirteen percent of deviations had a patient and/or a product impact score > or = 2, a score indicating, at a minimum, potentially affected patient outcome or moderate effect upon product quality. Real-time analysis and quarterly review of deviations using our deviation management program allows for identification and correction of deviations. Monitoring of deviation trends allows for process improvement and overall successful functioning of the QA program in the cell therapy laboratory. Our deviation management program could serve as a model for other laboratories in

  12. Quality requirements for vegetables and fruit products in the European Union : training manual, product quality standards including UN-ECE quality standards for unions

    NARCIS (Netherlands)

    Voort, van der M.P.J.; Baricicova, V.; Dandar, M.; Grzegorzewska, M.; Schoorlemmer, H.B.; Szabo, C.; Zmarlicji, K.

    2007-01-01

    This training manual is part of the pilot on agricultural quality standards. The objective of this pilot is the development and testing of a training course on quality requirements. The training manual informs growers and trainers on the basic quality requirements and the relationship of these

  13. Determination of inorganic arsenic in food and feed – European initiatives in research and standardization of methods

    DEFF Research Database (Denmark)

    Sloth, Jens Jørgen; Rasmussen, Rie Romme

    The European legislation on trace elements concerning food and feed safety is based on total element concentrations expressed as maximum levels. However, information on the total content of an element does not always provide adequate information for evaluation of e.g. bioavailability and toxicity....... These parameters may vary quite significantly depending on how the element is bound, i.e. its speciation, defined as the distribution of an element amongst defined chemical species in a system. The most important practical application of elemental speciation is in the area of toxicology and with the help of more...

  14. [Falling Short of Minimum Volume Standards, Exemptions and Their Consequences from 2018 Onwards. Complex Procedures on Oesophagus and Pancreas in German Hospitals from 2006 to 2014].

    Science.gov (United States)

    de Cruppé, Werner; Geraedts, Max

    2018-03-16

    The minimum volume standards for hospitals in Germany, in force since 2004, provide four exemptions for non-complying hospitals. This study investigates the extent and importance of these exemptions for complex procedures on the oesophagus and pancreas for all non-complying hospitals and for the revised minimum volume regulations in force since the beginning of 2018. Longitudinal, descriptive analyses of data on minimum volume standards and their exemptions for complex procedures on the oesophagus and pancreas, as presented by the hospital quality report cards of the reporting years from 2006 to 2014. For each year and both procedures, about 120 hospitals with some 500 cases report non-compliance with the minimum volume standards. Of these a third report no exemptions (with 180 procedures), a third state emergencies (110), and another third report exemptions due to internal hospital restructuring (210). Ensuring geographical access to care as an exemption is of no importance. After the three year exemption period for installation of a new service line, 20% of the hospitals with procedures on the oesophagus and 30% on the pancreas complied with the minimum volume standards. After the two-year period for staff realignment, the figures were 40 and 50%, respectively. Exemptions do not entirely explain all procedures performed by hospitals not complying with the minimum volume standards. The revised minimum volume regulations' restructuring of exemptions to "emergencies" and "new or renewed service lines" with a two year exemption period, are concordant with the empirical findings of this study. Georg Thieme Verlag KG Stuttgart · New York.

  15. The tsunami probabilistic risk assessment (PRA). Example of accident sequence analysis of tsunami PRA according to the standard for procedure of tsunami PRA for nuclear power plants

    International Nuclear Information System (INIS)

    Ohara, Norihiro; Hasegawa, Keiko; Kuroiwa, Katsuya

    2013-01-01

    After the Fukushima Daiichi nuclear power plant (NPP) accident, standard for procedure of tsunami PRA for NPP had been established by the Standardization Committee of AESJ. Industry group had been conducting analysis of Tsunami PRA for PWR based on the standard under the cooperation with electric utilities. This article introduced overview of the standard and examples of accident sequence analysis of Tsunami PRA studied by the industry group according to the standard. The standard consisted of (1) investigation of NPP's composition, characteristics and site information, (2) selection of relevant components for Tsunami PRA and initiating events and identification of accident sequence, (3) evaluation of Tsunami hazards, (4) fragility evaluation of building and components and (5) evaluation of accident sequence. Based on the evaluation, countermeasures for further improvement of safety against Tsunami could be identified by the sensitivity analysis. (T. Tanaka)

  16. Qualification, training, licensing and retraining of operating shift personnel in nuclear power plants. Presentation of different procedures in the countries of the European Community, Spain, Sweden, Switzerland and the USA

    International Nuclear Information System (INIS)

    Pfeffer, W.; Kraut, A.

    1985-01-01

    This study aims at evaluating and compiling the procedures to reach the necessary qualification applied in the countries of the European Community, Sweden, Spain, Switzerland and the United States of America. Additionally to the presentation of practice the report is to show similarities - as far as they were identified - and special topics or aspects worth mentioning. In the report the following topics are dealt with: tasks of the shift personnel, nomenclature for different groups of personnel; shift staffing of the control room; criteria for personnel selection when new shift staff; personnel qualification necessary for recruitment; training of shift personnel; retraining for preservation of the qualification standard; training facilities, especially simulators; licensing or authorization of shift personnel; training and education organization. The study is based on the evaluation of EC documents as well as well as general publications and reports. To check the results and to integrate some lacking information the report was discussed in a meeting of an ad hoc subgroup of the CEC working group dealing with the safety of light-water reactors, joined by specialists from Spain, Sweden and Switzerland. 121 refs

  17. Optimization of two methods based on ultrasound energy as alternative to European standards for soluble salts extraction from building materials.

    Science.gov (United States)

    Prieto-Taboada, N; Gómez-Laserna, O; Martinez-Arkarazo, I; Olazabal, M A; Madariaga, J M

    2012-11-01

    The Italian recommendation NORMAL 13/83, later replaced by the UNI 11087/2003 norm, were used as standard for soluble salts extraction from construction materials. These standards are based on long-time stirring (72 and 2h, respectively) of the sample in deionized water. In this work two ultrasound based methods were optimized in order to reduce the extraction time while efficiency is improved. The instrumental variables involved in the extraction assisted by ultrasound bath and focused ultrasounds were optimized by experimental design. As long as it was possible, the same non-instrumental parameters values as those of standard methods were used in order to compare the results obtained on a mortar sample showing a black crust by the standards and the optimized methods. The optimal extraction time for the ultrasounds bath was found to be of two hours. Although the extraction time was equal to the standard UNI 11087/2003, the obtained extraction recovery was improved up to 119%. The focused ultrasound system achieved also better recoveries (up to 106%) depending on the analyte in 1h treatment time. The repeatabilities of the proposed ultrasound based methods were comparables to those of the standards. Therefore, the selection of one or the other of the ultrasound based methods will depend on topics such as laboratory facilities or number of samples, and not in aspects related with their quality parameters. Copyright © 2012 Elsevier B.V. All rights reserved.

  18. U.S. Geological Survey Noble Gas Laboratory’s standard operating procedures for the measurement of dissolved gas in water samples

    Science.gov (United States)

    Hunt, Andrew G.

    2015-08-12

    This report addresses the standard operating procedures used by the U.S. Geological Survey’s Noble Gas Laboratory in Denver, Colorado, U.S.A., for the measurement of dissolved gases (methane, nitrogen, oxygen, and carbon dioxide) and noble gas isotopes (helium-3, helium-4, neon-20, neon-21, neon-22, argon-36, argon-38, argon-40, kryton-84, krypton-86, xenon-103, and xenon-132) dissolved in water. A synopsis of the instrumentation used, procedures followed, calibration practices, standards used, and a quality assurance and quality control program is presented. The report outlines the day-to-day operation of the Residual Gas Analyzer Model 200, Mass Analyzer Products Model 215–50, and ultralow vacuum extraction line along with the sample handling procedures, noble gas extraction and purification, instrument measurement procedures, instrumental data acquisition, and calculations for the conversion of raw data from the mass spectrometer into noble gas concentrations per unit mass of water analyzed. Techniques for the preparation of artificial dissolved gas standards are detailed and coupled to a quality assurance and quality control program to present the accuracy of the procedures used in the laboratory.

  19. Random access procedures and radio access network (RAN) overload control in standard and advanced long-term evolution (LTE and LTE-A) networks

    DEFF Research Database (Denmark)

    Kiilerich Pratas, Nuno; Thomsen, Henning; Popovski, Petar

    2015-01-01

    In this chapter, we describe and discuss the current LTE random access procedure and the Radio Access Network Load Control solution within LTE/LTE-A. We provide an overview of the several considered load control solutions and give a detailed description of the standardized Extended Access Class B...

  20. Diagnosis and dosimetry of exposure to sulfur mustard: Development of a standard operating procedure for hemoglobin adducts: Exploratory research on albumin and keratin adducts

    NARCIS (Netherlands)

    Noort, D.; Fidder, A.; Jong, L.P.A. de; Schans, G.P. van der; Benschop, H.P.

    2000-01-01

    A standard operating procedure (SOP) for determination of the sulfur mustard adduct to the N-terminal valine in hemoglobin was developed. By using this SOP, it was found that the Nterminal valine adduct in globin of hairless guinea pigs and marmosets which had been exposed to sulfur mustard (0.5

  1. An umbrella protocol for standardized data collection (SDC) in rectal cancer: a prospective uniform naming and procedure convention to support personalized medicine.

    Science.gov (United States)

    Meldolesi, Elisa; van Soest, Johan; Dinapoli, Nicola; Dekker, Andre; Damiani, Andrea; Gambacorta, Maria Antonietta; Valentini, Vincenzo

    2014-07-01

    Predictive models allow treating physicians to deliver tailored treatment moving from prescription by consensus to prescription by numbers. The main features of an umbrella protocol for standardizing data and procedures to create a consistent dataset useful to obtain a trustful analysis for a Decision Support System for rectal cancer are reported. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.

  2. Diagnosis and dosimetry of exposure to sulfur mustard: Development of a standard operating procedure for mass spectrometric analysis of haemoglobin adducts - Exploratory research on albumin and keratin adducts

    NARCIS (Netherlands)

    Noort, D.; Fidder, A.; Hulst, A.G.; Jong, L.P.A. de; Benschop, H.P.

    2000-01-01

    Experiments were carried out to develop a standard operating procedure for analysis of sulfur mustard adducts to the N-terminal valine in haemoglobin and to explore adduct formation with albumin and keratin. In the first approach, gas chromatography-negative chemical ionization/mass spectrometry

  3. A Guide for Developing Standard Operating Job Procedures for the Activated Sludge - Aeration & Sedimentation Process Wastewater Treatment Facility. SOJP No. 5.

    Science.gov (United States)

    Mason, George J.

    This guide for developing standard operating job procedures for wastewater treatment facilities is devoted to the activated sludge aeration and sedimentation process. This process is for conversion of nonsettleable and nonfloatable materials in wastewater to settleable, floculated biological groups and separation of the settleable solids from the…

  4. Transfer of near-infrared calibration model for determining fiber content in flax: effects of transfer samples and standardization procedure.

    Science.gov (United States)

    Sohn, Miryeong; Barton, Franklin E; Himmelsbach, David S

    2007-04-01

    The transfer of a calibration model for determining fiber content in flax stem was accomplished between two near-infrared spectrometers, which are the same brand but which require a standardization. In this paper, three factors, including transfer sample set, spectral type, and standardization method, were investigated to obtain the best standardization result. Twelve standardization files were produced from two sets of the transfer sample (sealed reference standards and a subset of the prediction set), two types of the transfer sample spectra (raw and preprocessed spectra), and three standardization methods (direct standardization (DS), piecewise direct standardization (PDS), and double window piecewise direct standardization (DWPDS)). The efficacy of the model transfer was evaluated based on the root mean square error of prediction, calculated using the independent prediction samples. Results indicated that the standardization using the sealed reference standards was unacceptable, but the standardization using the prediction subset was adequate. The use of the preprocessed spectra of the transfer samples led to the calibration transfers that were successful, especially for the PDS and the DWPDS correction. Finally, standardization using the prediction subset and their preprocessed spectra with DWPDS correction proved to be the best method for transferring the model.

  5. 16 CFR 1616.35 - Use of alternate apparatus, procedures, or criteria for testing under the standard.

    Science.gov (United States)

    2010-01-01

    ... SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY OF CHILDREN'S SLEEPWEAR... converter) initially introducing items subject to the Standard into commerce to group items into production units, and to test samples from each production unit. See 16 CFR 1616.4. The Standard prescribes an...

  6. 16 CFR 1615.35 - Use of alternate apparatus, procedures, or criteria for testing under the standard.

    Science.gov (United States)

    2010-01-01

    ... SAFETY COMMISSION FLAMMABLE FABRICS ACT REGULATIONS STANDARD FOR THE FLAMMABILITY OF CHILDREN'S SLEEPWEAR... converter) initially introducing items subject to the Standard into commerce to group items into production units, and to test samples from each production unit. See 16 CFR 1615.4 (b), (c) and (d). The Standard...

  7. Standard for administration of stable iodine pilulae. Standard of the nuclear safety commission, action for accident in TEPCO Fukushima-1 and recent European trends

    International Nuclear Information System (INIS)

    Ishihara, Hiroshi

    2011-01-01

    Preventive taking of stable-iodine tablets is effective to avoid thyroid gland disorder due to internal exposure to the radioactive iodine if radioactive iodine is released outside by any nuclear accident. In Japan, the Nuclear Safety Commission proposed the standard of the preventive taking in 2002, and, at the Fukushima Daiichi nuclear disaster, the head of the local task force instructed to take on the recommendation from the Commission. Author described the action principle of stable-iodine tablets, present concept for the preventive taking, recent change of the concept in Europe for the preventive taking, and some precepts which have shown in past Fukushima Daiichi nuclear disaster. (J.P.N.)

  8. Application of European standards for health and quality control of game meat on game ranches in South Africa

    Directory of Open Access Journals (Sweden)

    M. van der Merwe

    2011-04-01

    Full Text Available The health and quality compliance of game carcasses (n = 295 intended for the South African export market and aspiring to comply with the strict hygiene requirements of the European Union were compared with game carcasses (n = 330 available for the local market and currently not subjected to meat safety legislation. Samples were collected in similar seasons and geographical areas in South Africa from 2006 to 2009. Aerobic plate counts (APC of the heart blood verified that both groups possessed similar ante mortem bacterial status. For health compliance APC, tests for Escherichia coli, Salmonella spp. and Staphylococcus aureus were performed on the carcasses. Surfaces of the local carcasses were swabbed using the European Enviro-biotrace sponge technique at 3 and 72 h post mortem. Unskinned but eviscerated export carcasses in the abattoir were skinned and sampled by incision using a cork borer 72h post mortem . Temperature andpHreadings were recorded at 3 and 72 h post mortem from the longissimus dorsi muscle and the readings at 3 h differed (P = 0.035. Temperatures at 72 h were lower for export than local carcasses (P < 0.001 because of earlier introduction and maintenance of the cold chain. The pH readings also differed between groups at 3 and 72 h (P<0.001. APC results for the local group exceeded the maximum permissible count (<105. S. aureus results showed differences (P <0.001, with readings from the local group being higher. The same tendency was exhibited for E. coli (P = 0.008. Imposition of hygiene guidelines for game ranchers producing meat for the local market is therefore recommended.

  9. Radiation protection standards for radioluminous timepieces. Recommendations of the European Nuclear Energy Agency and the International Atomic Energy Agency

    International Nuclear Information System (INIS)

    1967-01-01

    Users of radioluminous timepieces are exposed to ionizing radiations from the luminous paints contained in the timepieces. There standards have been prepared to ensure that users of radioluminous timepieces are exposed to as little ionizing radiation as practicable, and not to levels in excess of the maximum permissible levels laid down in basic radiation protection standards; and that the contribution to the dose received by the whole population from the use of radioluminous timepieces is kept within the limits adopted by the appropriate national authority.

  10. PENYUSUNAN DRAFT STANDARD OPERATING PROCEDURE (SOP PENGOLAHAN KERIPIK PISANG (STUDI KASUS DI SALAH SATU INDUSTRI RUMAH TANGGA KERIPIK PISANG BANDAR LAMPUNG

    Directory of Open Access Journals (Sweden)

    Didit Haryanto

    2013-09-01

    Full Text Available Standard operating procedure (SOP is a procedure or steps which is standardized and must be passed to complete a particular work process. Arranging SOP draft is based on a review of Good Manufacture Practice. SOP is made for being a guide line in doing process in an industry. Purposes of this research is arranging SOP draft for home industries of banana chips making, so the product will meet the standard. In this research, drafting standard operating procedure (SOP of the banana chips industry was begun with observating and recording every detail process. The research was conducted through four steps. Firstly, field observation to observate  process, including sanitation, tools specification, and description about step of processing banana chips. Second step was determining the critical point and optimating the condition. The next step was arranging the SOP draft. The last was the testing of SOP draft. Then the data were compared and discussed descriptively.  The result was a SOP draft which was used as in processing banana chips the products consistenly had meet the standard quality of SNI 01-4315-1996, they include moisture content, ash content, fat content, wholeness, with flavor, aroma, color, and texture.  The analysis data are, Moisture content (0,17%, ash content (1,35%, fat content (27,90% and wholeness (88,00%. Otherwise the data analysis for banana chips that produce without SOP are, moisture content (0,15%, ash content (1,88%, fat content (39,41% and wholeness (83,00%. Keywords: standard operating procedure (SOP, banana chips, consistency of quality

  11. Double standards: a cross-European study on differences in norms on voluntary childlessness for men and women. Paper presentation

    NARCIS (Netherlands)

    Rijken, A.J.; Merz, E.-M.

    2011-01-01

    We examine double standards in norms on voluntary childlessness. Whether choosing childlessness is more accepted for men or for women is not a priori clear; we formulate arguments in both directions. Multilevel analyses are conducted, including individual and societal-level variables. Our sample

  12. Public play upon private standards : How European and international economic law enter into voluntary regimes for sustainability

    NARCIS (Netherlands)

    Partiti, E.D.

    2017-01-01

    The emergence, consolidation, and proliferation of private product standards in the domain of sustainability has been one of the most striking features in global governance in the social and environmental fields. Companies, sectoral associations and multi-stakeholder organisations set and enforce

  13. Protection of minors from sexual exploitation and abuse: The European standards and the Criminal Law of the Republic of Serbia

    Directory of Open Access Journals (Sweden)

    Miladinović-Stefanović Dušica

    2014-01-01

    Full Text Available The Convention for the Protection of Children against Sexual Exploitation and Sexual Abuse (2007 laid down the criminal law standards for the protection of minors. After the ratification of this Convention, these standards became part of the Serbian legal system but Serbia assumed an obligation to provide for their further elaboration and implementation. The obligation was put into effect by amending the Criminal Code (2009 and adopting the Act on Special Measures for the Prevention of Sex Crimes against Minors (2013. In that context, this paper is an attempt to critically examine the implementation of these standards in the field of general criminal law, the scope of criminal offences introduced to protect the sexual integrity of minors, the special measures for their protection and the special registers on the perpetrators of criminal offences involving sexual abuse against minors. In line with the projected subject matter, the primary goal of this research paper is to provide answers to several important questions: has Serbia managed to put the Convention capacities into good use; are there any other solutions for the specific implementation of general standards; and what are the practical implication of the accepted and possible solutions?.

  14. Diagnosis and Dosimetry of Exposure to Sulfur Mustard: Development of Standard Operating Procedures; Further Exploratory Research on Protein Adducts

    National Research Council Canada - National Science Library

    Benschop, H

    1999-01-01

    .... Both procedures could be substantially shortened, while their sensitivities were improved. Furthermore, exploratory research is performed aiming at the development of a fieldable immunochemical assay for sulfur mustard adducts with proteins, i.e...

  15. The Suggestion of Some Comparative European Group Corporate Governance Standards after Financial Crisis, Corporate Scandals and Manipulation

    OpenAIRE

    Dinh Tran Ngoc Huy

    2016-01-01

    In past few years, corporate scandals and bankruptcy in US and Europe and other parts of the world show some certain evidence on weak corporate governance, weak internal control system and weak audit. Though there are a few researches which have been done in the field of international corporate governance standards, we believe that this field with more rooms to explore. Therefore, this paper chooses a different analytical approach and among its aims is to give some systematic opinions. Fir...

  16. Direct cost analysis of intensive care unit stay in four European countries: applying a standardized costing methodology.

    Science.gov (United States)

    Tan, Siok Swan; Bakker, Jan; Hoogendoorn, Marga E; Kapila, Atul; Martin, Joerg; Pezzi, Angelo; Pittoni, Giovanni; Spronk, Peter E; Welte, Robert; Hakkaart-van Roijen, Leona

    2012-01-01

    The objective of the present study was to measure and compare the direct costs of intensive care unit (ICU) days at seven ICU departments in Germany, Italy, the Netherlands, and the United Kingdom by means of a standardized costing methodology. A retrospective cost analysis of ICU patients was performed from the hospital's perspective. The standardized costing methodology was developed on the basis of the availability of data at the seven ICU departments. It entailed the application of the bottom-up approach for "hotel and nutrition" and the top-down approach for "diagnostics," "consumables," and "labor." Direct costs per ICU day ranged from €1168 to €2025. Even though the distribution of costs varied by cost component, labor was the most important cost driver at all departments. The costs for "labor" amounted to €1629 at department G but were fairly similar at the other departments (€711 ± 115). Direct costs of ICU days vary widely between the seven departments. Our standardized costing methodology could serve as a valuable instrument to compare actual cost differences, such as those resulting from differences in patient case-mix. Copyright © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  17. Enzyme Replacement Therapy and/or Hematopoietic Stem Cell Transplantation at diagnosis in patients with Mucopolysaccharidosis type I: results of a European consensus procedure

    LENUS (Irish Health Repository)

    de Ru, Minke H

    2011-08-10

    Abstract Background Mucopolysaccharidosis type I (MPS I) is a lysosomal storage disorder that results in the accumulation of glycosaminoglycans causing progressive multi-organ dysfunction. Its clinical spectrum is very broad and varies from the severe Hurler phenotype (MPS I-H) which is characterized by early and progressive central nervous system (CNS) involvement to the attenuated Scheie phenotype (MPS I-S) with no CNS involvement. Indication, optimal timing, safety and efficacy of the two available treatment options for MPS I, enzyme replacement therapy (ERT) and hematopoietic stem cell transplantation (HSCT), are subject to continuing debate. A European consensus procedure was organized to reach consensus about the use of these two treatment strategies. Methods A panel of specialists, including 8 specialists for metabolic disorders and 7 bone marrow transplant physicians, all with acknowledged expertise in MPS I, participated in a modified Delphi process to develop consensus-based statements on MPS I treatment. Fifteen MPS I case histories were used to initiate the discussion and to anchor decisions around either treatment mode. Before and at the meeting all experts gave their opinion on the cases (YES\\/NO transplantation) and reasons for their decisions were collected. A set of draft statements on MPS I treatment options composed by a planning committee were discussed and revised during the meeting until full consensus. Results Full consensus was reached on several important issues, including the following: 1) The preferred treatment for patients with MPS I-H diagnosed before age 2.5 yrs is HSCT; 2) In individual patients with an intermediate phenotype HSCT may be considered if there is a suitable donor. However, there are no data on efficacy of HSCT in patients with this phenotype; 3) All MPS I patients including those who have not been transplanted or whose graft has failed may benefit significantly from ERT; 4) ERT should be started at diagnosis and may be

  18. Assessing the reliability of the borderline regression method as a standard setting procedure for objective structured clinical examination

    Directory of Open Access Journals (Sweden)

    Sara Mortaz Hejri

    2013-01-01

    Full Text Available Background: One of the methods used for standard setting is the borderline regression method (BRM. This study aims to assess the reliability of BRM when the pass-fail standard in an objective structured clinical examination (OSCE was calculated by averaging the BRM standards obtained for each station separately. Materials and Methods: In nine stations of the OSCE with direct observation the examiners gave each student a checklist score and a global score. Using a linear regression model for each station, we calculated the checklist score cut-off on the regression equation for the global scale cut-off set at 2. The OSCE pass-fail standard was defined as the average of all station′s standard. To determine the reliability, the root mean square error (RMSE was calculated. The R2 coefficient and the inter-grade discrimination were calculated to assess the quality of OSCE. Results: The mean total test score was 60.78. The OSCE pass-fail standard and its RMSE were 47.37 and 0.55, respectively. The R2 coefficients ranged from 0.44 to 0.79. The inter-grade discrimination score varied greatly among stations. Conclusion: The RMSE of the standard was very small indicating that BRM is a reliable method of setting standard for OSCE, which has the advantage of providing data for quality assurance.

  19. Comparison of Test Procedures and Energy Efficiency Criteria in Selected International Standards and Labeling Programs for Clothes Washers, Water Dispensers, Vending Machines and CFLs

    Energy Technology Data Exchange (ETDEWEB)

    Fridley, David; Zheng, Nina; Zhou, Nan

    2010-06-01

    Since the late 1970s, energy labeling programs and mandatory energy performance standards have been used in many different countries to improve the efficiency levels of major residential and commercial equipment. As more countries and regions launch programs covering a greater range of products that are traded worldwide, greater attention has been given to harmonizing the specific efficiency criteria in these programs and the test methods for measurements. For example, an international compact fluorescent light (CFL) harmonization initiative was launched in 2006 to focus on collaboration between Australia, China, Europe and North America. Given the long history of standards and labeling programs, most major energy-consuming residential appliances and commercial equipment are already covered under minimum energy performance standards (MEPS) and/or energy labels. For these products, such as clothes washers and CFLs, harmonization may still be possible when national MEPS or labeling thresholds are revised. Greater opportunity for harmonization exists in newer energy-consuming products that are not commonly regulated but are under consideration for new standards and labeling programs. This may include commercial products such as water dispensers and vending machines, which are only covered by MEPS or energy labels in a few countries or regions. As China continues to expand its appliance standards and labeling programs and revise existing standards and labels, it is important to learn from recent international experiences with efficiency criteria and test procedures for the same products. Specifically, various types of standards and labeling programs already exist in North America, Europe and throughout Asia for products in China's 2010 standards and labeling programs, namely clothes washers, water dispensers, vending machines and CFLs. This report thus examines similarities and critical differences in energy efficiency values, test procedure specifications and

  20. Development and evaluation of Standard Operating Procedures (SOPs) for quality control tests and radiological protection activities in a Nuclear Medicine Service

    International Nuclear Information System (INIS)

    Krempser, Alexandre R.; Soares, Alexandre B.; Corbo, Rossana

    2011-01-01

    The quality management in Nuclear Medicine Services is a requirement of national and international standards. The Brazilian regulatory agency in health surveillance, the Agencia Nacional de Vigilancia Sanitaria (ANVISA), in its Resolucao de Diretoria Colegiada (Collegiate Directory Resolution) no. 38, requires the elaboration of documents describing the technical and clinical routine activities. This study aimed to elaborate, implement and evaluate Standard Operating Procedures (SOPs) for quality control tests and radiological protection activities in the Nuclear Medicine Service of a university hospital. Eighteen SOPs were developed, involving tasks related to dose calibrator, gamma camera, Geiger-Muller detectors and radiological protection activities. The performance of its application was evaluated for a period of six months. It was observed a reduction in 75% of reported operational errors and 42% of the number of reported incidents with contamination by radioactive material. The SOPs were adequate and successful in its application. New procedures involving clinical activities will also be developed and evaluated. (author)

  1. Economy of Standards: European Association of Urology Guideline Changes Influence Treatment Costs in Stage I Testicular Cancer Patients.

    Science.gov (United States)

    John, Axel; Baumgart, André; Worst, Thomas; Heinzelbecker, Julia

    2018-01-01

    The study aimed to calculate direct medical costs (DMC) during the first year of diagnosis and to evaluate the impact of guideline changes on treatment costs in clinical stage (CS) I testicular germ cell tumor (TGCT) patients in a German healthcare system. Healthcare expenditures as DMC during the first year of diagnosis for 307 TGCT patients in CS I treated at our institution from 1987 to 2013 were calculated from the statutory health insurance perspective using patient level data. Three periods were defined referring to the first European Association of Urology (EAU) guideline in 2001 as well as to subsequent major guideline changes in 2005 and 2010. Data source for cost calculations were the German Diagnosis Related Groups system for inpatient stays (version 2014) and the German system for reimbursement of outpatient care (EBM - Einheitlicher Bewertungsmaßstab, edition 2014). During our 25 years of study period, mean DMC in the first year after diagnosis for the entire cohort of TGCT patients in CS I almost halved from EUR 13.000 to EUR 6.900 (p < 0.001). From 1987 to 2001, DMC for CS I seminomatous germ cell tumor (SGCT) patients were EUR 13.790 ± 4.700. From 2002 to 2010, mean costs were EUR 10.900 ± 5.990, and from 2011 to 2013, mean costs were EUR 5.190 ± 3.700. For CS I non-seminomatous germ cell tumor (NSGCT) patients, from 1987 to 2001, mean DMC were EUR 11.650 ± 5.690. From 2002 to 2010, mean costs were EUR 11.230 ± 5.990, and from 2011 to 2013, mean costs were EUR 11.170 ± 7.390. Follow-up examinations became less frequent over time, which caused a significant cost reduction for NSGCT (p = 0.042) while costs remained stable for SGCT. When adding costs of relapse treatment, active surveillance (AS) was the most cost-effective adjuvant treatment option in CS I NSGCT whereas one course carboplatin or AS caused similar expenditures in SGCT patients. The introduction of the EAU guidelines in 2001 caused a decrease in DMC in CS I seminoma patients

  2. First experiences with the implementation of the European standard EN 62304 on medical device software for the quality assurance of a radiotherapy unit.

    Science.gov (United States)

    Höss, Angelika; Lampe, Christian; Panse, Ralf; Ackermann, Benjamin; Naumann, Jakob; Jäkel, Oliver

    2014-03-21

    standards-compliant development of small and medium-sized medical software can be carried out by a small team with limited resources in a clinical setting. This is of particular relevance as the upcoming revision of the Medical Device Directive is expected to harmonize and tighten the current legal requirements for all European in-house manufacturers.

  3. First experiences with the implementation of the European standard EN 62304 on medical device software for the quality assurance of a radiotherapy unit

    International Nuclear Information System (INIS)

    Höss, Angelika; Lampe, Christian; Panse, Ralf; Ackermann, Benjamin; Naumann, Jakob; Jäkel, Oliver

    2014-01-01

    standards-compliant development of small and medium-sized medical software can be carried out by a small team with limited resources in a clinical setting. This is of particular relevance as the upcoming revision of the Medical Device Directive is expected to harmonize and tighten the current legal requirements for all European in-house manufacturers

  4. Coracoid bone graft osteolysis after Latarjet procedure: A comparison study between two screws standard technique vs mini-plate fixation

    Science.gov (United States)

    Giacomo, Giovanni Di; Costantini, Alberto; de Gasperis, Nicola; De Vita, Andrea; Lin, Bernard K. H.; Francone, Marco; Beccaglia, Mario A. Rojas; Mastantuono, Marco

    2013-01-01

    Aims: One of the reason for Latarjet procedure failure may be coracoid graft osteolysis. In this study, we aimed to understand if a better compression between the coracoid process and the glenoid, using a mini-plate fixation during the Latarjet procedure, could reduce the amount of coracoid graft osteolysis. Materials and Methods: A computed tomography scan analysis of 26 prospectively followed-up patients was conducted after modified Latarjet procedure using mini-plate fixation technique to determine both the location and the amount of coracoid graft osteolysis in them. We then compared our current results with results from that of our previous study without using mini-plate fixation to determine if there is any statistical significant difference in terms of corcacoid bone graft osteolysis between the two surgical techniques. Results: The most relevant osteolysis was represented by the superficial part of the proximal coracoid, whereas the deep part of the proximal coracoid graft is least involved in osteolysis and has best bone healing. The current study showed a significant difference only for the deep part of the distal coracoid with our previous study (P Latarjet procedure. Conclusion: Our study suggests that there is a significant difference only for the deep part of the distal coracoid in terms of osteolysis. At clinical examination, this difference did not correspond with any clinical findings. Level of Evidence: Level 4. Clinical Relevance: Prospective case series, Treatment study. PMID:23858288

  5. Enhancing Title Ix Due Process Standards in Campus Sexual Assault Adjudication: Considering the Roles of Distributive, Procedural, and Restorative Justice

    Science.gov (United States)

    Harper, Shannon; Maskaly, Jon; Kirkner, Anne; Lorenz, Katherine

    2017-01-01

    Title IX prohibits sex discrimination--including sexual assault--in higher education. The Department of Education Office for Civil Rights' 2011 "Dear Colleague Letter" outlines recommendations for campus sexual assault adjudication allowing a variety of procedures that fail to protect accused students' due process rights and victims'…

  6. 40 CFR 1045.515 - What are the test procedures related to not-to-exceed standards?

    Science.gov (United States)

    2010-07-01

    ... emissions with one of the following procedures: (1) Remove the selected engines for testing in a laboratory....075 (5) For two-stroke engines not equipped with a catalyst, the NTE zone described in paragraph (c)(3... cycle: (i) Mode 1: Operate the engine at wide open throttle. For laboratory testing, this may involve...

  7. Final Rule for Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

    Science.gov (United States)

    EPA adopted emission standards and related provisions for aircraft gas turbine engines with rated thrusts greater than 26.7 kilonewtons. These engines are used primarily on commercial passenger and freight aircraft.

  8. Functionality of the Kosovo Competition Authority on the basis of European Union standards a guarantee for loyal economy in Kosovo

    Directory of Open Access Journals (Sweden)

    Armand Krasniqi

    2015-07-01

    Full Text Available Legal regulation of market mechanisms and the implementation of economic policies for a fair competition in TEs is a challenging issue. The competition is a complex economic phenomenon that is manifested and characterized by the strength and content that gives to the market economy. In Kosovo specific economic entities, in one way or another, are tempted to gain as much buyers or markets and create much more profits. The problem is connected with the irregularity. Such behavior and unfair actions are not only damaging the image of the country but are a serious threat the harmonious development of the national economy and the country’s accession process to the EU. The parliament of Kosovo established the Kosovo Competition Authority as an independent institution with special competences to control and fight this negative phenomenon. Based to official data it turns out that the effectiveness of this institution is not only incomplete but also non-functional. This is because of the “ignorance” and non-adequate treatment that is reserved for this authority by the parliamentary and governmental institutions. All this because the members are not elected based to regular procedures and not allocating the necessary financial means to operate. At least so far, the Kosovo Competition Authority was not allowed to hire professionals with clear competences to act and investigate the negative phenomenon of unfair competition. Certainly, this situation does not guarantee effective implementation of laws and quality protection of competition. Therefore, the mobilization of parliamentary and governmental levels is needed to enhance professional capacities and increase their competence in scope of the investigation including cooperation with prosecutors and courts. These actions should be reconsidered with the aim of creating a competitive safe environment for all operators. To conclude, the loyal competition policies and legislative framework should be

  9. The European Narcolepsy Network (EU-NN) database

    DEFF Research Database (Denmark)

    Khatami, Ramin; Luca, Gianina; Baumann, Christian R

    2016-01-01

    diseases is to establish a distributed expert network. A first and important step is to create a database that allows collection, storage and dissemination of data on narcolepsy in a comprehensive and systematic way. Here, the first prospective web-based European narcolepsy database hosted by the European...... a few European countries have registered narcolepsy cases in databases of the International Classification of Diseases or in registries of the European health authorities. A promising approach to identify disease-specific adverse health effects and needs in healthcare delivery in the field of rare...... Narcolepsy Network is introduced. The database structure, standardization of data acquisition and quality control procedures are described, and an overview provided of the first 1079 patients from 18 European specialized centres. Due to its standardization this continuously increasing data pool is most...

  10. Optimised use of High Strength Steels for Pressure Vessels by Application of Modern Design Methods According to European Standards

    Science.gov (United States)

    Langenberg, P.

    During the last 40 years, steel industry has developed high strength fine grain steels with excellent material properties and weldability for use in pressure vessels, as well as for structural buildings, offshore platforms, wind mills and ships. Application of such modern steels is often restricted due to lack of knowledge concerning questions of safety and downstream fabrication processes such as welding, bending and PWHT. However, if new toughness-oriented design rules as they were developed in several International research projects are accepted, such modern steels can be applied leading to economic advantages and sustainable use of resources while safety remains on the required level. The predominant question for safe constructions is related to toughness and quality survey during downstream fabrication. This question today is answered with the application of fracture mechanics based safety concepts and a better understanding of fracture and deformation behavior of structural components. In addition it must be underlined that beyond a widely spread understanding of standard C-Mn structural steels, modern micro alloyed structural steels provide far higher quality in terms of toughness, strength, inner soundness and optimal fabrication properties. With this presentation it shall demonstrated how modern micro-alloyed steels and modern toughness-oriented design methods can be applied for pressure vessels steels with thickness up to 200 mm operating at low temperatures.

  11. Patient Recall of Informed Consent at 4 Weeks After Total Hip Replacement With Standardized Versus Procedure-Specific Consent Forms.

    Science.gov (United States)

    Pomeroy, Eoghan; Shaarani, Shahril; Kenyon, Robert; Cashman, James

    2017-08-25

    Informed consent plays a pivotal role in the operative process, and surgeons have an ethical and legal obligation to provide patients with information to allow for shared decision-making. Unfortunately, patient recall after the consent process is frequently poor. This study aims to evaluate the effect of procedure-specific consent forms on patient's recall four weeks after total hip replacement (THR). This is a prospective study using a posttest-only control group design. Sixty adult patients undergoing total hip replacement were allocated to be consented using either the generic or the surgery-specific consent form. Four weeks after surgery, a phone interview was conducted to assess patient's recall of risk of surgical complications. Patient demographic characteristics and educational attainment were similar in both groups. There was a statistically significant increase in the mean number of risks recalled in the study group at 1.43 compared with 0.67 in the control group (P = 0.0131). Consent is a complex process, and obtaining informed consent is far from straightforward. A statistically significant improvement in patient's recall with the use of procedure-specific consent forms was identified, and based on this, we would advocate their use. However, overall patient recall in both groups was poor. We believe that improving the quality of informed consent may require the sum of small gains, and the use of procedure-specific consent forms may aid in this regard.

  12. Validation of the G.LAB MD2200 wrist blood pressure monitor according to the European Society of Hypertension, the British Hypertension Society, and the International Organization for Standardization Protocols.

    Science.gov (United States)

    Liu, Ze-Yu; Zhang, Qing-Han; Ye, Xiao-Lei; Liu, Da-Peng; Cheng, Kang; Zhang, Chun-Hai; Wan, Yi

    2017-04-01

    To validate the G.LAB MD2200 automated wrist blood pressure (BP) monitors according to the European Society of Hypertension International Protocol (ESH-IP) revision 2010, the British Hypertension Society (BHS), and the International Organization for Standardization (ISO) 81060-2:2013 protocols. The device was assessed on 33 participants according to the ESH requirements and was then tested on 85 participants according to the BHS and ISO 81060-2:2013 criteria. The validation procedures and data analysis followed the protocols precisely. The G.LAB MD2200 devices passed all parts of ESH-IP revision 2010 for both systolic and diastolic BP, with a device-observer difference of 2.15±5.51 and 1.51±5.16 mmHg, respectively. The device achieved A/A grading for the BHS protocol and it also fulfilled the criteria of ISO 81060-2:2013, with mean differences of systolic and diastolic BP between the device and the observer of 2.19±5.21 and 2.11±4.70 mmHg, respectively. The G.LAB MD2200 automated wrist BP monitor passed the ESH-IP revision 2010 and the ISO 81060-2:2013 protocol, and achieved the A/A grade of the BHS protocol, which can be recommended for self-measurement in the general population.

  13. A proposal of Brazilian Society of Surgical Oncology for standardizing cytoreductive surgery plus hypertermic intraperitoneal chemotherapy procedures in Brazil: pseudomixoma peritonei, appendiceal tumors and malignant peritoneal mesothelioma

    Directory of Open Access Journals (Sweden)

    Thales Paulo Batista

    Full Text Available ABSTRACT Cytoreductive surgery plus hypertermic intraperitoneal chemotherapy has emerged as a major comprehensive treatment of peritoneal malignancies and is currently the standard of care for appendiceal epithelial neoplasms and pseudomyxoma peritonei syndrome as well as malignant peritoneal mesothelioma. Unfortunately, there are some worldwide variations of the cytoreductive surgery and hypertermic intraperitoneal chemotherapy techniques since no single technique has so far demonstrated its superiority over the others. Therefore, standardization of practices might enhance better comparisons between outcomes. In these settings, the Brazilian Society of Surgical Oncology considered it important to present a proposal for standardizing cytoreductive surgery plus hypertermic intraperitoneal chemotherapy procedures in Brazil, with a special focus on producing homogeneous data for the developing Brazilian register for peritoneal surface malignancies.

  14. A Randomized Controlled Trial to Compare e-Feedback Versus "Standard" Face-to-Face Verbal Feedback to Improve the Acquisition of Procedural Skill.

    Science.gov (United States)

    Al-Jundi, Wissam; Elsharif, Mohamed; Anderson, Melanie; Chan, Phillip; Beard, Jonathan; Nawaz, Shah

    Constructive feedback plays an important role in learning during surgical training. Standard feedback is usually given verbally following direct observation of the procedure by a trained assessor. However, such feedback requires the physical presence of expert faculty members who are usually busy and time-constrained by clinical commitments. We aim to evaluate electronic feedback (e-feedback) after video observation of surgical suturing in comparison with standard face-to-face verbal feedback. A prospective, blinded, randomized controlled trial comparing e-feedback with standard verbal feedback was carried out in February 2015 using a validated pro formas for assessment. The study participants were 38 undergraduate medical students from the University of Sheffield, UK. They were recorded on video performing the procedural skill, completed a self-evaluation form, and received e-feedback on the same day (group 1); observed directly by an assessor, invited to provide verbal self-reflection, and then received standard verbal feedback (group 2). In both groups, the feedback was provided after performing the procedure. The participants returned 2 days later and performed the same skill again. Poststudy questionnaire was used to assess the acceptability of each feedback among the participants. Overall, 19 students in group 1 and 18 students in group 2 completed the study. Although there was a significant improvement in the overall mean score on the second performance of the task for all participants (first performance mean 11.59, second performance mean 15.95; p ≤ 0.0001), there was no difference in the overall mean improvement score between group 1 and group 2 (4.74 and 3.94, respectively; p = 0.49). The mean overall scores for the e-feedback group at baseline recorded by 2 independent investigators showed good agreement (mean overall scores of 12.84 and 11.89; Cronbach α = 0.86). Poststudy questionnaire demonstrated that both e-feedback and standard verbal feedback

  15. 77 FR 36341 - Control of Air Pollution From Aircraft and Aircraft Engines; Emission Standards and Test Procedures

    Science.gov (United States)

    2012-06-18

    ... normally expressed as shaft horsepower (hp) or shaft kilowatt (kW). \\5\\ This includes turbofan and turbojet... Organization (ICAO). The requirements contained in this final rule bring the United States into alignment with... brought the U.S. standards closer to alignment with ICAO CAEP/4 requirements that were effective in 2004...

  16. 20 CFR 627.604 - Alternative procedure for handling labor standards violations under section 143 of the Act...

    Science.gov (United States)

    2010-04-01

    ... standards violations under section 143 of the Act-binding arbitration. 627.604 Section 627.604 Employees... UNDER TITLES I, II, AND III OF THE ACT Federal Handling of Noncriminal Complaints and Other Allegations...—binding arbitration. (a) A person alleging a violation of section 143 of the Act, as an alternative to...

  17. Standard Procedure for Dose Assessment using the film holder NRPB/AERE and the film AGFA Monitoring 2/10

    International Nuclear Information System (INIS)

    Guillen, J.A.

    1998-07-01

    This paper describes the calculation method to assess dose and energy using the film holder from NRPB/AERE and the film Agfa Monitoring 2/10. Also includes all the steps since preparing the standard curve, fitting of calibration curve, dose assesment, description of filtration of the film holder and the form of the calibration curve

  18. Comparison of SKIFS 2004:1 and Tillsynshandbok PSA against the ASME PRA Standard and European requirements on PSA; Jaemfoerelse av SKIFS 2004:1 och Tillsynshandbok PSA mot ASME PRA Standard och Europeiska krav paa PSA

    Energy Technology Data Exchange (ETDEWEB)

    Hellstroem, Per

    2005-04-15

    Requirements on PSA for risk informed applications are expressed in different international documents. The ASME PRA standard published in spring 2002 is one such document, PSA requirements are also expressed in the European Utility Requirements (EUR) for new reactors. The Swedish PSA requirements are provided in the Swedish regulators (SKI) statutes SKIFS 2004:1. SKI also has a review handbook for PSA activities (SKI report 2003:48). The review handbook is a support during review of the utilities PSA activities and the PSAs themselves. The review handbook expresses SKIs expectations by providing so called important aspects for both the PSA work and the PSAs, A comparison of SKIFS requirements and the important aspects in the Review handbook, on one side, and the requirements on PSA in EUR and ASME on the other side, is presented. The comparison shows a large difference in the level of detail in the different documents, where ASME is most detailed and specific. This is expected since the SKI review handbook not is a 'PSA guide' in the same way as the ASME PRA standard. A direct comparison of the ASME PRA standard requirements with the important aspects in the review handbook cannot answer the question which ASME capacity level that is achieved by a PSA meeting all important aspects. The conclusion is that it is not likely to achieve capacity level 2 and 3, since very few ASME level 3 attributes are explicitly expressed as important aspects, though many are expressed in general terms. The review handbook important aspects that are most similar to the ASME capacity level 1 attributes are initiating events, sequence analysis, and system analysis while less similarity is found for analysis of operator actions data analysis, quantification and containment analysis (level 2). Less similarity is found for capacity level 2 and 3. However, the number of additional ASME attributes on capacity level 2 and 3 are few. There are also important aspects in the review

  19. Conscious sedation for endoscopic and non-endoscopic interventional gastrointestinal procedures: meeting patients' expectations, missing the standard

    Energy Technology Data Exchange (ETDEWEB)

    Marriott, P.; Laasch, H.-U.; Wilbraham, L.; Marriott, A.; England, R.E.; Martin, D.F. E-mail: derrick.martin@smtr.nhs.uk

    2004-02-01

    AIM: To assess the level of sedation, patient satisfaction and frequency of unplanned events with conscious sedation for interventional procedures. MATERIALS AND METHODS: One hundred and seventeen patients were assessed prospectively before, during and after procedures. Blood pressure, pulse, oxygen saturation and sedation level were monitored and patients followed up after 24 h. Sedation was scored after drugs were given in accordance with an established protocol. Doses were recorded, as were patients' weight, age and ASA grade and any unplanned events and their management. RESULTS: Seventy-six of the 117 patients (65%) had no unplanned event, 20 (17.1%) became agitated, 15 (12.8%) hypotensive, three (2.6%) hypoxic and three (2.6%) had more than one response. Twelve patients required active management. Fifty-two (44.4%) had a sedation level of {<=}3 (responsive to verbal commands), but 39 (33.3%) reached level 6. Median doses were midazolam 6 mg (1-20 mg) and pethidine 50 mg (12.5-100 mg). Ninety-three percent were satisfied with their sedation. No adverse effects were observed after 24 h. CONCLUSION: Despite using a sedation protocol, unplanned events occurred in 35% (95% CI=27-44%) of patients, although not all required active management. The sedation levels reached in some exceeded guidelines. Unplanned events were commoner with increased sedation level. Patient satisfaction was high and no permanent damage was observed.

  20. Conscious sedation for endoscopic and non-endoscopic interventional gastrointestinal procedures: meeting patients' expectations, missing the standard

    International Nuclear Information System (INIS)

    Marriott, P.; Laasch, H.-U.; Wilbraham, L.; Marriott, A.; England, R.E.; Martin, D.F.

    2004-01-01

    AIM: To assess the level of sedation, patient satisfaction and frequency of unplanned events with conscious sedation for interventional procedures. MATERIALS AND METHODS: One hundred and seventeen patients were assessed prospectively before, during and after procedures. Blood pressure, pulse, oxygen saturation and sedation level were monitored and patients followed up after 24 h. Sedation was scored after drugs were given in accordance with an established protocol. Doses were recorded, as were patients' weight, age and ASA grade and any unplanned events and their management. RESULTS: Seventy-six of the 117 patients (65%) had no unplanned event, 20 (17.1%) became agitated, 15 (12.8%) hypotensive, three (2.6%) hypoxic and three (2.6%) had more than one response. Twelve patients required active management. Fifty-two (44.4%) had a sedation level of ≤3 (responsive to verbal commands), but 39 (33.3%) reached level 6. Median doses were midazolam 6 mg (1-20 mg) and pethidine 50 mg (12.5-100 mg). Ninety-three percent were satisfied with their sedation. No adverse effects were observed after 24 h. CONCLUSION: Despite using a sedation protocol, unplanned events occurred in 35% (95% CI=27-44%) of patients, although not all required active management. The sedation levels reached in some exceeded guidelines. Unplanned events were commoner with increased sedation level. Patient satisfaction was high and no permanent damage was observed

  1. Standard procedure for testing acute toxic effects on bioluminescent bacteria; Saggio di tossicita` acuta con batteri bioluminescenti

    Energy Technology Data Exchange (ETDEWEB)

    Guzzella, L. [CNR, Brugherio, Milan (Italy). Istituto di Ricerca Sulle Acque

    1996-06-01

    A standardized method for the determination of 15-30 min toxicity of `Vibrio fisheri` bioluminescent bacteria is evaluated. The proposed method can be applied for the analysis of liquid (superficial and drinking waters, eluates and wastes) and solid (sediments and muds) samples and permits the quantification of the EC50 and EC20 values and of the no-effective sample dilution. The results of a interlaboratory ring tests conducted with reference substances are illustrated.

  2. MATLAB-implemented estimation procedure for model-based assessment of hepatic insulin degradation from standard intravenous glucose tolerance test data.

    Science.gov (United States)

    Di Nardo, Francesco; Mengoni, Michele; Morettini, Micaela

    2013-05-01

    Present study provides a novel MATLAB-based parameter estimation procedure for individual assessment of hepatic insulin degradation (HID) process from standard frequently-sampled intravenous glucose tolerance test (FSIGTT) data. Direct access to the source code, offered by MATLAB, enabled us to design an optimization procedure based on the alternating use of Gauss-Newton's and Levenberg-Marquardt's algorithms, which assures the full convergence of the process and the containment of computational time. Reliability was tested by direct comparison with the application, in eighteen non-diabetic subjects, of well-known kinetic analysis software package SAAM II, and by application on different data. Agreement between MATLAB and SAAM II was warranted by intraclass correlation coefficients ≥0.73; no significant differences between corresponding mean parameter estimates and prediction of HID rate; and consistent residual analysis. Moreover, MATLAB optimization procedure resulted in a significant 51% reduction of CV% for the worst-estimated parameter by SAAM II and in maintaining all model-parameter CV% MATLAB-based procedure was suggested as a suitable tool for the individual assessment of HID process. Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

  3. Energy policy in Eastern Europe and the European Union standard; Energiebeleid Oost-Europe is nog ver weg van EU-standaard

    Energy Technology Data Exchange (ETDEWEB)

    Oosterheert, R.; Van Harmelen, T.; Van Oostvoorn, F.; Uyterlinde, M. [ECN Beleidsstudies, Petten (Netherlands)

    1997-11-01

    From the results of a comparative study it appears that there still are large differences between East European countries and the members of the European Union with respect to energy policies. Some of the differences can be solved easily. However, where it concerns the energy intensity the gap is still very wide, not only between Western Europe and Eastern Europe, but also between the East European countries. The study on the title subject was carried out by ECN Policy Studies in cooperation with 5 West European research institutes and local partners in 10 European Union associate countries. 2 figs., 7 refs.

  4. PLAN-TA9-2443(U), Rev. B Remediated Nitrate Salt (RNS) Surrogate Formulation and Testing Standard Procedure

    Energy Technology Data Exchange (ETDEWEB)

    Brown, Geoffrey Wayne [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2016-03-16

    This document identifies scope and some general procedural steps for performing Remediated Nitrate Salt (RNS) Surrogate Formulation and Testing. This Test Plan describes the requirements, responsibilities, and process for preparing and testing a range of chemical surrogates intended to mimic the energetic response of waste created during processing of legacy nitrate salts. The surrogates developed are expected to bound1 the thermal and mechanical sensitivity of such waste, allowing for the development of process parameters required to minimize the risk to worker and public when processing this waste. Such parameters will be based on the worst-case kinetic parameters as derived from APTAC measurements as well as the development of controls to mitigate sensitivities that may exist due to friction, impact, and spark. This Test Plan will define the scope and technical approach for activities that implement Quality Assurance requirements relevant to formulation and testing.

  5. Human rights standards for targeted sanctions

    NARCIS (Netherlands)

    Cortright, D.; de Wet, E.

    2010-01-01

    Legal scholar Erika de Wet and sanctions expert David Cortright team up to analyze the core principles of international human rights law in relation to the procedures for the imposition of targeted sanctions by the UN Security Council and the European Union. They define core legal standards such as

  6. Accounting standards

    NARCIS (Netherlands)

    Stellinga, B.; Mügge, D.

    2014-01-01

    The European and global regulation of accounting standards have witnessed remarkable changes over the past twenty years. In the early 1990s, EU accounting practices were fragmented along national lines and US accounting standards were the de facto global standards. Since 2005, all EU listed

  7. The ageing and myasthenic thymus: a morphometric study validating a standard procedure in the histological workup of thymic specimens.

    Science.gov (United States)

    Ströbel, Philipp; Moritz, Regina; Leite, Maria Isabel; Willcox, Nick; Chuang, Wen-Yu; Gold, Ralf; Nix, Wilfred; Schalke, Berthold; Kiefer, Reinhard; Müller-Hermelink, Hans-Konrad; Jaretzki Iii, Alfred; Newsom-Davis, John; Marx, Alexander

    2008-09-15

    The thymus is believed to play an important role in the pathogenesis of myasthenia gravis (MG). The 80% of MG patients with anti-acetylcholine receptor autoantibodies fall into three clinical subgroups: 1) thymoma; 2) early-onset MG (standardized histological workup and reporting system used in this trial.

  8. Randomized trial of one-hour sodium bicarbonate vs standard periprocedural saline hydration in chronic kidney disease patients undergoing cardiovascular contrast procedures.

    Science.gov (United States)

    Kooiman, Judith; de Vries, Jean-Paul P M; Van der Heyden, Jan; Sijpkens, Yvo W J; van Dijkman, Paul R M; Wever, Jan J; van Overhagen, Hans; Vahl, Antonie C; Aarts, Nico; Verberk-Jonkers, Iris J A M; Brulez, Harald F H; Hamming, Jaap F; van der Molen, Aart J; Cannegieter, Suzanne C; Putter, Hein; van den Hout, Wilbert B; Kilicsoy, Inci; Rabelink, Ton J; Huisman, Menno V

    2018-01-01

    Guidelines advise periprocedural saline hydration for prevention of contrast induced-acute kidney injury (CI-AKI). We analysed whether 1-hour sodium bicarbonate hydration administered solely prior to intra-arterial contrast exposure is non-inferior to standard periprocedural saline hydration in chronic kidney disease (CKD) patients undergoing elective cardiovascular diagnostic or interventional contrast procedures. We performed an open-label multicentre non-inferiority trial between 2011-2014. Patients were randomized to 1 hour pre-procedure sodium bicarbonate hydration (250 ml 1.4%, N = 168) or 4-12 hours saline hydration (1000 ml 0.9%, N = 165) prior to and following contrast administration (2000 ml of saline total). Primary outcome was the relative serum creatinine increase (%) 48-96 hours post contrast exposure. Secondary outcomes were: incidence of CI-AKI (serum creatinine increase>25% or >44μmol/L), recovery of renal function, the need for dialysis, and hospital costs within two months follow-up. Mean relative creatinine increase was 3.1% (95%CI 0.9 to 5.2%) in the bicarbonate and 1.1% (95%CI -1.2 to 3.5%) in the saline arm, mean difference 1.9% (95%CI -1.2 to 5.1%, p-non-inferiority sodium bicarbonate and 12 (7.5%) to saline (p = 0.79). Renal function did not fully recover in 40.0% and 44.4% of CI-AKI patients, respectively (p = 0.84). No patient required dialysis. Mean costs for preventive hydration and clinical preparation for the contrast procedure were $1158 for sodium bicarbonate vs. $1561 for saline (p sodium bicarbonate prior to elective cardiovascular diagnostic or therapeutic contrast procedures is non-inferior to standard periprocedural saline hydration in CKD patients with respect to renal safety and results in considerable healthcare savings. Netherlands Trial Register (http://www.trialregister.nl/trialreg/index.asp), Nr NTR2699.

  9. Standardization of a Protocol for Obtaining Platelet Rich Plasma from blood Donors; a Tool for Tissue Regeneration Procedures.

    Science.gov (United States)

    Gómez, Lina Andrea; Escobar, Magally; Peñuela, Oscar

    2015-01-01

    To develop a protocol for obtaining autologous platelet rich plasma in healthy individuals and to determine the concentration of five major growth factors before platelet activation. This protocol could be integrated into the guidelines of good clinical practice and research in regenerative medicine. Platelet rich plasma was isolated by centrifugation from 38 healthy men and 42 women ranging from 18 to 59 years old. The platelet count and quantification of growth factors were analyzed in eighty samples, stratified for age and gender of the donor. Analyses were performed using parametric the t-test or Pearson's analysis for non-parametric distribution. P platelet counts from 1.6 to 4.9 times (mean = 2.8). There was no correlation between platelet concentration and the level of the following growth factors: VEGF-D (r = 0.009, p = 0.4105), VEGF-A (r = 0.0068, p = 0.953), PDGF subunit AA (p = 0.3618; r = 0.1047), PDGF-BB (p = 0.5936; r = 0.6095). In the same way, there was no correlation between donor gender and growth factor concentrations. Only TGF-β concentration was correlated to platelet concentration (r = 0.3163, p = 0.0175). The procedure used allowed us to make preparations rich in platelets, low in leukocytes and red blood cells, and sterile. Our results showed biological variations in content of growth factors in PRP. The factors influencing these results should be further studied.

  10. Evaluation and assessment methodology, standards, and procedures manual of the United States Federal Radiological Monitoring and Assessment Center

    International Nuclear Information System (INIS)

    Kerns, K.C.; Burson, Z.G.; Smith, J.M.; Blanchard, R.L.

    2000-01-01

    In the event of a major radiological emergency, the U.S. Federal Radiological Emergency Response Plan authorises the creation of the Federal Radiological Monitoring and Assessment Center (FRMAC). The FRMAC is established to co-ordinate the Federal off-site monitoring and assessment activities, and is comprised of representatives from several Federal agencies and Department of Energy contractors who provide assistance to the state(s) and Lead Federal Agency. The Evaluation and Assessment (E and A) Division of the FRMAC is responsible for receiving, storing, and interpreting environmental surveillance data to estimate the potential health consequences to the population in the vicinity of the accident site. The E and A Division has commissioned the preparation of a methodology and procedures manual which will result in a consistent approach by Division members in carrying out their duties. The first edition of this manual is nearing completion. In this paper, a brief review of the structure of the FRMAC is presented, with emphasis on the E and A Division. The contents of the E and A manual are briefly described, as are future plans for its expansion. (author)

  11. International Cooperation to Establish Standard Operating Procedure (SOP) for Quarantine Management of Irradiated Foods in International Trade

    International Nuclear Information System (INIS)

    Lee, J. W.; Byun, M. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Yoon, Y. H.; Kim, D. H.; Kim, W. G.; Kim, K. P.

    2010-02-01

    · Development of SOPs through various research activities such as building international cooperation, and analysing current status of food irradiation in domestic and international markets, export and import, international market size, and of R and D - Analysis of examples for quarantine management in agricultural product exporting countries and use of irradiation technology for agricultural product quarantine, and changes in international quarantine management - Analysis of SOPs for food irradiation quarantine in international organization (CODEX, IPPC, WHO). U.S, EU, China, India, and Australia. - Collaborative researches of India/Korea and China/Korea entered into an agreement for market trials · Publishment of irradiation quarantine management SOPs agreed to CODEX standards - Collaborative researches for quarantine management, avoiding Technical Barrier to Trade (TBT), and Sanitary Phytosanitary Measures were conducted, and advanced SOPs agreed with WTO/FTA system were published

  12. Microprocessing in European High Energy Physics Experiments - ECFA Working Group on Data Processing Standards - Report of the Microprocessor Subgroup May 1982

    CERN Document Server

    European Committee for Future Accelerators (ECFA)

    1982-01-01

    This document contains two reports on the use of microprocessors in European High-Energy Physics experiments. The first is a presentation of data collected by a sub-group of the ECFA working group on data procesing standards. The working group is organised by E. Lillestol, University of Bergen and E.M. Rimmer, CERN, DD Division; the Microprocessor sub-group organiser is L.O. Hertzberger, NIKHEF, Amsterdam. Data are given from projects numbered 81 - 194, and some CERN projects are included. Even though there is some duplication of information, a second report has been appended which covers a wider range of CERN projects. This was the result of a microprocessor survey made at CERN by P. Scharff-Hansen, DD Division, at the request of E. Gabthuler. The ECFA working group intends to have reports for all the sub-groups (10 in number) available in machine-readable form at the CERN computer centre. However, it was felt that the information herein is most valuable to designers and users of microprocessors, and that it...

  13. A Decade of Information on the Use of Cardiac Implantable Electronic Devices and Interventional Electrophysiological Procedures in the European Society of Cardiology Countries

    DEFF Research Database (Denmark)

    Raatikainen, M J Pekka; Arnar, David O; Merkely, Bela

    2017-01-01

    in the access to invasive arrhythmia therapies still exists across the five geographical ESC regions. In 2016, the device implantation rates per million population were 3-6 times higher in the Western region than in the non-European and Eastern ESC member countries. Catheter ablation activity was highest...

  14. Mutagenic treatments towards increasing the frequency of day-neutral mutations and standardization of procedures for tissue culture, in potato

    International Nuclear Information System (INIS)

    Upadhya, M.D.; Chandra, R.; Abraham, M.J.

    1976-01-01

    Various chemical mutagens and gamma radiation have been used on single dormant eyes and true seeds with a view to finding effective mutagenic treatment for the induction of day-length neutral mutants in potato using an effective screening technique for the isolation of day-length neutral mutants. Sodium meta bisulphite (SMS) was found to be an efficient mutagen in inducing mutations for this trait in true seeds although the same concentrations, when used for treating the single tuber eyes proved lethal. Pre-soaking the seeds for 24 hrs prior to treatment with 0.0025M SMS gave highest frequency of the mutants followed by 48 hrs presoaking, indicating a sensitive stage during the cell cycle in true seeds. Other mutagen treatments gave different frequencies of mutations. The highest frequency of day-length neutral mutants was observed when seeds irradiated with 40 Kr of gamma radiation were treated with 0.05M hydrazinium dichloride solution. Screening procedures have also been standardised with the development of synethetic media for the isolation of biochemical mutants at the true seed level. Initial efforts have yielded mutants resistant to LD 100 doses of ethionine. Another aspect of the study was to develop a proper potato callus culture technique. A medium has been developed to produce and maintain callus from potato leaf strips. Efforts on the regeneration of shoot and roots from callus, have so far lead to differentiation of callus to form roots. The ultimate aim of these studies is to develop plantlets from single cell which would form the units of mutation induction and isolation. (author)

  15. Powered bone marrow biopsy procedures produce larger core specimens, with less pain, in less time than with standard manual devices

    Directory of Open Access Journals (Sweden)

    Larry J. Miller

    2011-07-01

    Full Text Available Bone marrow sampling remains essential in the evaluation of hematopoietic and many non-hematopoietic disorders. One common limitation to these procedures is the discomfort experienced by patients. To address whether a Powered biopsy system could reduce discomfort while providing equivalent or better results, we performed a randomized trial in adult volunteers. Twenty-six subjects underwent bilateral biopsies with each device. Core samples were obtained in 66.7% of Manual insertions; 100% of Powered insertions (P=0.002. Initial mean biopsy core lengths were 11.1±4.5 mm for the Manual device; 17.0±6.8 mm for the Powered device (P<0.005. Pathology assessment for the Manual device showed a mean length of 6.1±5.6 mm, width of 1.0±0.7 mm, and volume of 11.0±10.8 mm3. Powered device measurements were mean length of 15.3±6.1 mm, width of 2.0±0.3 mm, and volume of 49.1±21.5 mm3 (P<0.001. The mean time to core ejection was 86 seconds for Manual device; 47 seconds for the Powered device (P<0.001. The mean second look overall pain score was 33.3 for the Manual device; 20.9 for the Powered (P=0.039. We conclude that the Powered biopsy device produces superior sized specimens, with less overall pain, in less time.

  16. The American Society of Regional Anesthesia and Pain Medicine, the European Society of Regional Anaesthesia and Pain Therapy, and the Asian Australasian Federation of Pain Societies Joint Committee recommendations for education and training in ultrasound-guided interventional pain procedures.

    Science.gov (United States)

    Narouze, Samer N; Provenzano, David; Peng, Philip; Eichenberger, Urs; Lee, Sang Chul; Nicholls, Barry; Moriggl, Bernhard

    2012-01-01

    The use of ultrasound in pain medicine for interventional axial, nonaxial, and musculoskeletal pain procedures is rapidly evolving and growing. Because of the lack of specialty-specific guidelines for ultrasonography in pain medicine, an international collaborative effort consisting of members of the Special Interest Group on Ultrasonography in Pain Medicine from the American Society of Regional Anesthesia and Pain Medicine, the European Society of Regional Anaesthesia and Pain Therapy, and the Asian Australasian Federation of Pain Societies developed the following recommendations for education and training in ultrasound-guided interventional pain procedures. The purpose of these recommendations is to define the required skills for performing ultrasound-guided pain procedures, the processes for appropriate education, and training and quality improvement. Training algorithms are outlined for practice- and fellowship-based pathways. The previously published American Society of Regional Anesthesia and Pain Medicine and European Society of Regional Anaesthesia and Pain Therapy education and teaching recommendations for ultrasound-guided regional anesthesia served as a foundation for the pain medicine recommendations. Although the decision to grant ultrasound privileges occurs at the institutional level, the committee recommends that the training guidelines outlined in this document serve as the foundation for educational training and the advancement of the practice of ultrasonography in pain medicine.

  17. Philosophy, policy and procedures of the World Organisation for Animal Health for the development of standards in animal welfare.

    Science.gov (United States)

    Petrini, A; Wilson, D

    2005-08-01

    Animal welfare was identified as a priority for the World Organisation for Animal Health (OIE) in the 2001-2005 OIE Strategic Plan. Member Countries recognised that, as animal protection is a complex, multi-faceted public policy issue which includes important scientific, ethical, economic and political dimensions, the OIE needed to develop a detailed vision and strategy incorporating and balancing these dimensions. A permanent working group on animal welfare was established in order to provide guidance to the OIE in its work on the development of science-based standards and guidelines. The Working Group decided to give priority to the welfare of animals used in agriculture and aquaculture, and that, within those groups, the topics of transportation, slaughter for human consumption and killing for disease control purposes would be addressed first. Some guiding principles were approved by the International Committee of OIE Member Countries during the 72nd General Session in May 2004, and these have been followed by four specific guidelines on the priority topics listed above.

  18. Preparation procedure and certification of uranous-uranic oxide and nitric acid solution of neptunium as standard specimens of plant

    International Nuclear Information System (INIS)

    Bulyanitsa, L.S.; Lipovskij, A.A.; Ryzhinskij, M.V.; Preobrazhensskaya, L.D.; Aleksandruk, V.M.; Alekseeva, N.A.; Gromova, E.A.; Solntseva, L.F.; Shereshevskaya, I.I.

    1981-01-01

    Two techniques of certification of standard specimens of plant (SSP) are considered. The first technique-comparison with initial SS-metallic uranium NBS-960 - is used for certification of uranium. protoxide-oxide. The mass part of the sum of analyzed impurities in prepared initial SS is (8.4+-0.8)x10 -3 %. For certification according to mass uranium part the method of gravimetric potentiometric titration with semiautomatic titrator is used; the mean quadratic deviation of the method is s=0.0002-0.0003, certified value of uranium mass part in SSP (taking account of the error of initial SS) is (84.80+-0.02)%. The second technigue - a simplified circular experiment - is used for certification of SSP-nitric acid solution of neptunium as to Np mass part. Coulometry at controlled potential and coulometry at controlled current and two variants of potentiometric titration are used as certification methods of analysis. Relative mean quadratic deviations of the methods are ssub(r)=0.0014-0.0023. When calculating total error of certified value of neptunium mass part constituents of both accidental and unremoved systematic errors of the methods were included. The final certification result of SSP is (5.707+-0.018)% [ru

  19. European core curriculum in neurorehabilitation

    NARCIS (Netherlands)

    Sandrini, G.; Binder, H.; Homberg, V.; Saltuari, L.; Tarkka, I.; Smania, N.; Corradini, C.; Giustini, A.; Katterer, C.; Picari, L.; Diserens, K.; Koenig, E.; Geurts, A.C.; Anghelescu, A.; Opara, J.; Tonin, P.; Kwakkel, G.; Golyk, V.; Onose, G.; Perennou, D.; Picelli, A.

    2017-01-01

    To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation

  20. Changes in the biochemical oxygen demand procedure in the 21st edition of Standard Methods for the Examination of Water and Wastewater.

    Science.gov (United States)

    Young, James C; Clesceri, Lenore S; Kamhawy, Sabry M

    2005-01-01

    The dilution biochemical oxygen demand (BOD) test has widespread application for design and operation of wastewater treatment processes, evaluating the quality of natural waters, and assessing the effect of wastewater discharges on these waters. While standardization of the BOD-measuring method has become of prime importance in maintaining dependable data acquisition, changes are made as needed in response to questions raised by analysts and to accommodate new applications. The purpose of this article is to describe changes that have been incorporated in the 20th and 21st editions of Standard Methods for the Examination of Water and Wastewater (APHA et al., 1998 and 2004). These changes include changes in text format to clarify the procedural steps, allowance for use of bottle sizes ranging from 60 mL or larger, improvements in quality-control procedures, and improvements in the method of calculating BOD. Other changes include allowance for the use of allylthiourea for nitrification inhibition and broadening the source of seed that can be used for inoculation of BOD samples.

  1. [Advantages and disadvantages of different methods for the implementation and the support of standard operating procedures: From PDF files to an app- and webbased SOP management system].

    Science.gov (United States)

    Bauer, M; Riech, S; Brandes, I; Waeschle, R M

    2015-11-01

    The quality assurance of care and patient safety, with increasing cost pressure and performance levels is of major importance in the high-risk and high cost area of the operating room (OR). Standard operating procedures (SOP) are an established tool for structuring and standardization of the clinical treatment pathways and show multiple benefits for quality assurance and process optimization. An internal project was initiated in the department of anesthesiology and a continuous improvement process was carried out to build up a comprehensive SOP library. In the first step the spectrum of procedures in anesthesiology was transferred to PDF-based SOPs. The further development to an app-based SOP library (Aesculapp) was due to the high resource expenditure for the administration and maintenance of the large PDF-based SOP collection and to deficits in the mobile availability. The next developmental stage, the SOP healthcare information assistant (SOPHIA) included a simplified and advanced update feature, an archive feature previously missing and notably the possibility to share the SOP library with other departments including the option to adapt each SOP to the individual situation. A survey of the personnel showed that the app-based allocation of SOPs (Aesculapp, SOPHIA) had a higher acceptance than the PDF-based developmental stage SOP form. The SOP management system SOPHIA combines the benefits of the forerunner version Aesculapp with improved options for intradepartmental maintenance and administration of the SOPs and the possibility of an export and editing function for interinstitutional exchange of SOPs.

  2. Effect of Music on Outpatient Urological Procedures: A Systematic Review and Meta-Analysis from the European Association of Urology Section of Uro-Technology.

    Science.gov (United States)

    Kyriakides, Rena; Jones, Patrick; Geraghty, Robert; Skolarikos, Andreas; Liatsikos, Evangellos; Traxer, Olivier; Pietropaolo, Amelia; Somani, Bhaskar K

    2018-05-01

    Music is a practical, inexpensive and harmless analgesic and anxiolytic. An increasing number of original studies have been performed to investigate its potential application in urology. Our aim was to identify the effect of music on outpatient based urological procedures. We systematically reviewed the effect of using music during all reported outpatient urology procedures, including transrectal ultrasound guided prostate biopsy, shock wave lithotripsy, urodynamic studies, percutaneous nephrostomy tube placement and cystoscopy. Data were included on all randomized trials from 1980 to 2017 and no language restrictions were applied. Included in analysis were 16 randomized studies in which 972 of 1,950 patients (49.8%) were exposed to music during an outpatient procedure. The procedures included transrectal ultrasound guided prostate biopsy in 4 studies in a total of 286 patients, shock wave lithotripsy in 6 studies in a total of 1,023, cystoscopy in 3 studies in a total of 331, urodynamics in 2 studies in a total of 210 and percutaneous nephrostomy in 1 study in a total of 100. All studies incorporated a visual analog score to measure pain. Anxiety was measured by STAI (State-Trait Anxiety Inventory) in 13 studies and by a visual analog scale in 2. While 14 of the 16 studies showed a reduction in self-reported pain, a reduction in anxiety was seen in 14. When using music, overall procedural satisfaction was better in 9 studies and patient willingness to repeat the procedure was also higher in 7. Our meta-analysis revealed a significant reduction in visual analog scale and STAI findings across all studies (p <0.001). Our systematic review demonstrated a beneficial effect of music on urological outpatient procedures. Music seemed to decrease anxiety and pain. It might serve as a useful adjunct to increase procedural satisfaction and patient willingness to undergo the procedure again. Copyright © 2018 American Urological Association Education and Research, Inc

  3. Environmental procedures

    International Nuclear Information System (INIS)

    1992-01-01

    The European Bank has pledged in its Agreement to place environmental management at the forefront of its operations to promote sustainable economic development in central and eastern Europe. The Bank's environmental policy is set out in the document titled, Environmental Management: The Bank's Policy Approach. This document, Environmental Procedures, presents the procedures which the European Bank has adopted to implement this policy approach with respect to its operations. The environmental procedures aim to: ensure that throughout the project approval process, those in positions of responsibility for approving projects are aware of the environmental implications of the project, and can take these into account when making decisions; avoid potential liabilities that could undermine the success of a project for its sponsors and the Bank; ensure that environmental costs are estimated along with other costs and liabilities; and identify opportunities for environmental enhancement associated with projects. The review of environmental aspects of projects is conducted by many Bank staff members throughout the project's life. This document defines the responsibilities of the people and groups involved in implementing the environmental procedures. Annexes contain Environmental Management: The Bank's Policy Approach, examples of environmental documentation for the project file and other ancillary information

  4. Bridging the gap: Research and validation of the DST (Dynamic System Testing) performance test method for CE and ISO standards. Progress and preliminary results

    NARCIS (Netherlands)

    Naron, D.J.; Ree, B.G.C. van der; Rolloos, M.

    1998-01-01

    The Dynamic System Testing (DST) method is one of the methods chosen in the preliminary CEN/TC 312 European quality standards [1 ] to measure the energetic performance of Solar Domestic Hot Water (SDHW) systems. These European standards make a reference to the DST procedure as defined in the Draft

  5. Juveniles in criminal procedure

    Directory of Open Access Journals (Sweden)

    Lukić Tatjana

    2012-01-01

    Full Text Available Taking into consideration the importance and role of children in modern society, as well as their position, this article has as its focus juveniles in criminal procedure. The existence of a separate juvenile justice system independent of the criminal law applicable to the adult offenders and general criminal procedure, as well as the periodic changes of the dominant approach in theory and practice reflects the ascendancy of different theoretical perspectives in the juvenile justice. In this paper, the authors scrutinize the models of responding to juvenile crime - justice and welfare model - as two models of the greatest importance in the present reaction of the society to the crimes conducted by the youngest delinquents at the beginning of the new century and millennium. Furthermore, the paper deals with a matter of international legal standards which, to a large extent, give shape to the legal framework for juvenile offenders and provide their rights and position in the criminal procedure. The authors refer to the internationally accepted documents on several levels. From the (almost universally accepted multilateral conventions on human rights, through the field of recommendations, rules and guidelines which are obeyed and enforced in practice of the juvenile justice although they are of non-binding nature, via the regional European legislative to the national provisions in a particular number of countries. On all the levels mentioned above the rights of the juveniles are regulated having in mind their possible role in the criminal procedure as a perpetrator of a criminal act, as a victim or as a witness. This paper also analyzes the criminal procedure with respect to juvenile perpetrators of the criminal acts in the Republic of Serbia and compliance of the provisions currently in vigor with the international legal standards contained in the international conventions and other internationally accepted and recognized instruments.

  6. Visceral larvae as a predictive index of the overall level of fish batch infection in European anchovies (Engraulis encrasicolus): A rapid procedure for Food Business Operators to assess marketability.

    Science.gov (United States)

    Guardone, L; Nucera, D; Pergola, V; Costanzo, F; Costa, E; Tinacci, L; Guidi, A; Armani, A

    2017-06-05

    standard. The proposed LpG showed very high Specificity and Sensitivity. These findings suggest that the analysis of VM is representative of the overall infestation of the batch, both when considering the absolute number of parasites and the LpG, and may represent a valid alternative to the whole anchovy digestion. In particular, the use of an automated digestive method, coupled with the aforesaid sampling plan, could allow the procedure to be used by FBOs in operational conditions. Copyright © 2017 Elsevier B.V. All rights reserved.

  7. Curriculum content, structure and ECTS for European dental schools. Part II: methods of learning and teaching, assessment procedures and performance criteria.

    NARCIS (Netherlands)

    Plasschaert, A.J.M.; Manogue, M.; Lindh, C.; McLoughlin, J.; Murtomaa, H.; Nattestad, A.; Sanz, M.

    2007-01-01

    This paper presents a brief context of dental undergraduate curricular structure and content and lays out the Association for Dental Education in Europe's views on requirements and recommendations for learning, teaching and assessment procedures/performance.

  8. Review of a monograph by L. I. Broslavskiy “Technical regulation and standardization of goods quality and environment safety. Laws and realities in Russia, the USA and the European Union”

    Directory of Open Access Journals (Sweden)

    Albina S. Panova

    2018-03-01

    Full Text Available Objective to conduct a comprehensive analysis of a monograph by L. I. Broslavskiy devoted to the study of technical regulation and standardization of quality and safety of products and the environment in the Russian Federation the United States and the European Union. Methods dialectical approach to cognition of social phenomena which allows analyzing them in historical development and functioning in the context of a set of objective and subjective factors which determined the choice of the following research methods formallegal comparativelegal etc. Results the main approaches presented in the reviewed monograph are evaluated concerning the legal nature of technical regulation and standardization the system of documentation on standardization the practice of technical regulation and standardization in the Russian Federation the United States of America and the European Union. Scientific novelty for the first time the provisions presented in the monograph were estimated namely the provisions on the legal nature of standardization on the coordination of technical regulation and standardization normative acts and lawenforcement practice in the sphere of technical regulation and standardization of Russia the United States of America and the European Union the authorrsquos proposals aimed at improvement of the Russian Law No. 184FZ ldquoOn technical regulationrdquo of 27.12.2002 and No. 162FZ ldquoOn standardization in the Russian Federationrdquo of 29.06.2015. The conclusion is made about the essential contribution of L. I. Broslavskiyrsquos monograph to the development of the Russian legal doctrine on technical regulation and standardization. Practical significance the reviewer concludes that the monographic research by L. I. Broslavskiy can be used by scientists professors of law and economics at universities and faculties practicing lawyers employees of industrial enterprises representatives of the judiciary system and of the federal and

  9. The CE-mark and the new European approach to product law: a system of fundamental legal safety requirements and technical specification standards

    NARCIS (Netherlands)

    Brack, Antoni

    1999-01-01

    European product law consists of three parts: product liability law, a general product safety regulation and an increasing number of provisions with requirements on product group level. In recent years this third part has been revised in order to speed up the completion of the European single

  10. Road tunnels safety according to European legislation

    Directory of Open Access Journals (Sweden)

    Fedor KÁLLAY

    2008-01-01

    Full Text Available The article deals with safety of European road tunnels in accordance with actual European legislation. Standards and recommendations of European Commission, PIARC and other professional bodies of the European Union define minimal technological requirements for equipment and operation of the tunnels in scope of Trans-European Road Network.

  11. Public contracts by negotiated procedure in cases of urgency – a new interpretation of the legal basis in light of experiences with organization of the 2012 European Football Championships

    Directory of Open Access Journals (Sweden)

    Krzysztof Horubski

    2013-06-01

    Full Text Available The negotiated procedure without publication of a contract notice is a special procedure for awarding public procurement contracts which departs from the obligation imposed on contracting authorities of respecting the freedoms of the internal market and rules of competition. The procedure may be applied in exceptional situations of extreme urgency resulting from an event which could not be foreseen. The current judicature of the Court of Justice of the EU provides interpretations of the legal basis for application of the procedure in specific cases. However, it does not address the issue of whether it is possible to regard improper performance of contractual obligations as unpredictable. It does not provide broader considerations concerning the form of regulations on the procedure of awarding public interest contracts either. These issues were subject to analysis in one of the resolutions of the National Appeal Chamber (KIO – the Polish authority issuing decisions in matters related to public procurement contracts. In resolution KIO/KD 58/10 of 6 August 2010, KIO assessed the correctness of the application of the negotiated procedure for changing the contractor of the Municipal Stadium in Wrocław in the run-up to the 2012 European Football Championships. KIO found that the significant delay in construction of the facility was unpredictably exceptional, and significantly threatened the timeliness of commissioning the facility, which resulted in termination of the agreement by the contracting authority. The resolution also included an assessment allowing for the position that such a situation was exceptional due to the scale of the threat to the public interest, including the commercial interest of the contracting authority, stemming from a lack of immediate performance of the contract if it resulted in disproportionate consequences for a specific community. The issue of acceptance of such an interpretation by EU institutions remains unresolved.

  12. Evaluation and standardization of different purification procedures for fish bile and liver metallothionein quantification by spectrophotometry and SDS-PAGE analyses.

    Science.gov (United States)

    Tenório-Daussat, Carolina Lyrio; Resende, Marcia Carolina Martinho; Ziolli, Roberta L; Hauser-Davis, Rachel Ann; Schaumloffel, Dirk; Saint'Pierre, Tatiana D

    2014-03-01

    Fish bile metallothioneins (MT) have been recently reported as biomarkers for environmental metal contamination; however, no studies regarding standardizations for their purification are available. Therefore, different procedures (varying centrifugation times and heat-treatment temperatures) and reducing agents (DTT, β-mercaptoethanol and TCEP) were applied to purify MT isolated from fish (Oreochromis niloticus) bile and liver. Liver was also analyzed, since these two organs are intrinsically connected and show the same trend regarding MT expression. Spectrophotometrical analyses were used to quantify the resulting MT samples, and SDS-PAGE gels were used to qualitatively assess the different procedure results. Each procedure was then statistically evaluated and a multivariate statistical analysis was then applied. A response surface methodology was also applied for bile samples, in order to further evaluate the responses for this matrix. Heat treatment effectively removes most undesired proteins from the samples, however results indicate that temperatures above 70 °C are not efficient since they also remove MTs from both bile and liver samples. Our results also indicate that the centrifugation times described in the literature can be decreased in order to analyze more samples in the same timeframe, of importance in environmental monitoring contexts where samples are usually numerous. In an environmental context, biliary MT was lower than liver MT, as expected, since liver accumulates MT with slower detoxification rates than bile, which is released from the gallbladder during feeding, and then diluted by water. Therefore, bile MT seems to be more adequate in environmental monitoring scopes regarding recent exposure to xenobiotics that may affect the proteomic and metalloproteomic expression of this biological matrix. Copyright © 2013 Elsevier B.V. All rights reserved.

  13. Antenna standards and laboratories in Europe

    DEFF Research Database (Denmark)

    Lemanczyk, Jerzy

    1994-01-01

    to these two instances, other parallel organizations in this field exist such as the Western European Laboratory Accreditation Cooperation (WELAC), the Western European Calibration Cooperation (WECC) which includes EUROMET, the European Collaboration for Measurement Standards and the European...

  14. A working procedure for identifying emerging food safety issues at an early stage: Implications for European and international risk management practices

    NARCIS (Netherlands)

    Marvin, H.J.P.; Kleter, G.A.; Frewer, L.J.; Cope, S.F.; Wentholt, M.T.A.; Rowe, G.

    2009-01-01

    There is a need for early identification of emerging food safety issues in order to prevent them from developing into health risks. In this paper, various existing methods and procedures which can be used for early identification of safety issues are reviewed, including the monitoring of the

  15. Methodology of Isochronal and Isothermal Anneals applied to Irradiated MOS Structures. Application to Post-Irradiation Effects (in Space, Accelerators) and Standard Test Procedures

    International Nuclear Information System (INIS)

    Chabrerie, Christian

    1997-01-01

    We report the development of a methodology using isochronal and isothermal anneals for the characterization of MOS (Metal - Oxide - Semiconductor) Transistors irradiated electronic components. We study the recovery kinetics of the post-irradiation effects and the modeling of the recovery temperature activated phenomena. This allows us to understand the basic physical mechanisms that have led to the definition of standard test procedures. The fields of application are numerous (space, military, accelerators for high energy physics, civilian nuclear and harsh environment robotics). We begin by outlining the context of our study and by presenting the actual standard test procedures (TM1019.4 and BS22900) used for the qualification of integrated circuits. We then review the different theories of the temperature activated phenomena. The link between the foundations of the normalized procedures and the thermally activated phenomena is clarified. From this analysis, we propose a new approach, mainly based on the use of isochronal anneals. During this work, we have developed two tools with this aim: - the first tool is software, it is a numerical simulation program for thermally activated phenomena. - The second is composed of a specific automated annealing bench (in particular isochronal), that we have designed. The applications and results are then presented in four parts: - the first presents simulation results computed using our calculation code, - the second concerns experimental results obtained with thin oxides from different rad-hard technologies and their application to study gate oxides of transistors, - the third develops results on non-hardened technological thick oxides and their consequences on the lateral leakage currents due to parasitic MOS structures in the 'commercial' components, - the fourth concerns the post-irradiation evolution of interface states during isochronal anneals. We conclude with a number of recommendations concerning the post

  16. A prospective case control comparison of the ZeroGravity system versus a standard lead apron as radiation protection strategy in neuroendovascular procedures.

    Science.gov (United States)

    Haussen, Diogo C; Van Der Bom, Imramsjah Martijn John; Nogueira, Raul G

    2016-10-01

    We aimed to compare the performance of the ZeroGravity (ZG) system (radiation protection system composed by a suspended lead suit) against the use of standard protection (lead apron (LA), thyroid shield, lead eyeglasses, table skirts, and ceiling suspended shield) in neuroangiography procedures. Radiation exposure data were prospectively collected in consecutive neuroendovascular procedures between December 2014 and February 2015. Operator No 1 was assigned to the use of an LA (plus lead glasses, thyroid shield, and a 1 mm hanging shield at the groin) while operator No 2 utilized the ZG system. Dosimeters were used to measure peak skin dose for the head, thyroid, and left foot. The two operators performed a total of 122 procedures during the study period. The ZG operator was more commonly the primary operator compared with the LA operator (85% vs 71%; p=0.04). The mean anterior-posterior (AP), lateral, and cumulative dose area product (DAP) radiation exposure as well as the mean fluoroscopy time were not statistically different between the operators' cases. The peak skin dose to the head of the operator with LA was 2.1 times higher (3380 vs 1600 μSv), while the thyroid was 13.9 (4460 vs 320 μSv), the mediastinum infinitely (520 vs 0 μSv), and the foot 3.3 times higher (4870 vs 1470 μSv) compared with the ZG operator, leading to an overall accumulated dose 4 times higher. The ratio of cumulative operator received dose/total cumulative DAP was 2.5 higher on the LA operator. The ZG radiation protection system leads to substantially lower radiation exposure to the operator in neurointerventional procedures. However, substantial exposure may still occur at the level of the lens and thyroid to justify additional protection. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/

  17. Procedimientos Comunes de Operacion Para Juntas Responsabilidades y Derechos del Presidente, Vice Presidente, Secretaria, y Miembros (Standard Procedures of Operation for Meetings, Rights, and Responsibilities of the President, Vice President, Secretary, and Members).

    Science.gov (United States)

    Gonzalez, Ramon

    Of use to Parent Advisory Committees, this Spanish-English handout briefly describes the standard procedures used to conduct meetings and outlines the duties of committee officers and members. The pamphlet describes the standard order of business at a meeting, including calling a meeting to order, roll call, minutes, reports, unfinished and new…

  18. Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.

    Science.gov (United States)

    Loftus, Tyler J; Mira, Juan C; Ozrazgat-Baslanti, Tezcan; Ghita, Gabriella L; Wang, Zhongkai; Stortz, Julie A; Brumback, Babette A; Bihorac, Azra; Segal, Mark S; Anton, Stephen D; Leeuwenburgh, Christiaan; Mohr, Alicia M; Efron, Philip A; Moldawer, Lyle L; Moore, Frederick A; Brakenridge, Scott C

    2017-08-01

    Sepsis is a common, costly and morbid cause of critical illness in trauma and surgical patients. Ongoing advances in sepsis resuscitation and critical care support strategies have led to improved in-hospital mortality. However, these patients now survive to enter state of chronic critical illness (CCI), persistent low-grade organ dysfunction and poor long-term outcomes driven by the persistent inflammation, immunosuppression and catabolism syndrome (PICS). The Sepsis and Critical Illness Research Center (SCIRC) was created to provide a platform by which the prevalence and pathogenesis of CCI and PICS may be understood at a mechanistic level across multiple medical disciplines, leading to the development of novel management strategies and targeted therapies. Here, we describe the design, study cohort and standard operating procedures used in the prospective study of human sepsis at a level 1 trauma centre and tertiary care hospital providing care for over 2600 critically ill patients annually. These procedures include implementation of an automated sepsis surveillance initiative, augmentation of clinical decisions with a computerised sepsis protocol, strategies for direct exportation of quality-filtered data from the electronic medical record to a research database and robust long-term follow-up. This study has been registered at ClinicalTrials.gov, approved by the University of Florida Institutional Review Board and is actively enrolling subjects. Dissemination of results is forthcoming. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2017. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  19. Effectiveness of facilitated introduction of a standard operating procedure into routine processes in the operating theatre: a controlled interrupted time series.

    Science.gov (United States)

    Morgan, Lauren; New, Steve; Robertson, Eleanor; Collins, Gary; Rivero-Arias, Oliver; Catchpole, Ken; Pickering, Sharon P; Hadi, Mohammed; Griffin, Damian; McCulloch, Peter

    2015-02-01

    Standard operating procedures (SOPs) should improve safety in the operating theatre, but controlled studies evaluating the effect of staff-led implementation are needed. In a controlled interrupted time series, we evaluated three team process measures (compliance with WHO surgical safety checklist, non-technical skills and technical performance) and three clinical outcome measures (length of hospital stay, complications and readmissions) before and after a 3-month staff-led development of SOPs. Process measures were evaluated by direct observation, using Oxford Non-Technical Skills II for non-technical skills and the 'glitch count' for technical performance. All staff in two orthopaedic operating theatres were trained in the principles of SOPs and then assisted to develop standardised procedures. Staff in a control operating theatre underwent the same observations but received no training. The change in difference between active and control groups was compared before and after the intervention using repeated measures analysis of variance. We observed 50 operations before and 55 after the intervention and analysed clinical data on 1022 and 861 operations, respectively. The staff chose to structure their efforts around revising the 'whiteboard' which documented and prompted tasks, rather than directly addressing specific task problems. Although staff preferred and sustained the new system, we found no significant differences in process or outcome measures before/after intervention in the active versus the control group. There was a secular trend towards worse outcomes in the postintervention period, seen in both active and control theatres. SOPs when developed and introduced by frontline staff do not necessarily improve operative processes or outcomes. The inherent tension in improvement work between giving staff ownership of improvement and maintaining control of direction needs to be managed, to ensure staff are engaged but invest energy in appropriate change

  20. European Community law. The treaties establishing the EC. The law on legal procedure within the EC. The statutes of the Council of Europe. The European Convention on Human Rights. Text edition with detailed index and an introduction by Professor Dr. Ernst Steindorff. As of October 1, 1991. 11. rev. and enlarged ed. Europa-Recht. Vertraege und Erklaerungen zur Gruendung der Europaeischen Gemeinschaften, Abkommen ueber gemeinsame Organe, Satzung des Europarates, Verfahrensordnungen, Menschenrechtskonvention, Einheitliche Europaeische Akte, Europawahl-Gesetz, Europaabgeordnetengesetz. Textausgabe mit ausfuehrlichem Sachverzeichnis und einer Einfuehrung von Professor Dr. Ernst Steindorff. Stand 1. Oktober 1991

    Energy Technology Data Exchange (ETDEWEB)

    Steindorf, E.

    1992-01-01

    The book presents the authentic texts, as amended and updated, of the treaties and declarations establishing the European Communities, the Convention on Instutions, Common to the European Communities, the Statutes of the Council of Europe, rules of procedure, the European Convention on Human Rights, the European Single Act, the Act on Election of German Delegates to the European Parliament, EuWG, and the Act on the legal status of members of the European Parliament representing the FRG, (EuAbgG). The introduction gives a brief outline of items or developments of particular interest, as e.g. the process of European integration, the development of the Communities, - common market, politics- , developments outside the European Communities, the Europe of the Citizens, the Federal Republic of Germany within the EC: since the reunification of Germany, the EC has been issuing numerous special arrangements for the new federal Lands in the eastern part of the FRG. (orig./HSCH).

  1. The German and European laws and regulations providing for participation of the public in vertically staged procedures for the licensing of large-scale projects with an impact on the environment

    International Nuclear Information System (INIS)

    Hellmann, U.

    1992-01-01

    Participation of the public in licensing procedures for large-scale projects has been an item of discussion since the sixties in the legal sciences and on the political level. The introduction of the environmental impact assessment (EIA) as a legal requirement in EC law and its implementation in practice was the occasion to once again investigate the principle of participation of the public in the current legal framework. The study in hand reviews the legal provisions found in administrative law, constitutional law and European Community law governing the right of participation of the public and also takes a look at the situation in practice. The results show both the legal status and conditions of enforcement as prevailing after the coming into force in 1989 of the Act on Performance of an EIA, as well as inadequacies and deficits in the current legal framework. (orig.) [de

  2. Meeting US and European supplier control requirements.

    Science.gov (United States)

    Donawa, Maria

    2009-01-01

    Medical device manufacturers operating under European quality system requirements are sometimes surprised to learn that their supplier control procedures do not fully meet United States (US) requirements. This article discusses important differences between US and European requirements for controlling suppliers.

  3. Comparison of meal patterns across five European countries using standardized 24-h recall (GloboDiet) data from the EFCOVAL project

    NARCIS (Netherlands)

    Park, Min Kyung; Freisling, Heinz; Huseinovic, Ena; Winkvist, Anna; Huybrechts, Inge; Crispim, Sandra Patricia; Vries, de Jeanne H.M.; Geelen, Anouk; Niekerk, Maryse; Rossum, van Caroline; Slimani, Nadia

    2018-01-01

    Purpose: To examine meal patterns in terms of frequency and circadian timing of eating in five European countries participating in the EFCOVAL project. Methods: In this cross-sectional study, 559 men and women, aged 44–65 years, were recruited in Belgium, the Czech Republic, France (Southern part),

  4. Comparison of meal patterns across five European countries using standardized 24-h recall (GloboDiet) data from the EFCOVAL project

    NARCIS (Netherlands)

    Park, Min Kyung; Freisling, Heinz; Huseinovic, Ena; Winkvist, Anna; Huybrechts, Inge; Crispim, Sandra Patricia; Vries, de Jeanne H.M.; Geelen, Anouk; Niekerk, Maryse; Rossum, van Caroline; Slimani, Nadia

    2017-01-01

    Purpose: To examine meal patterns in terms of frequency and circadian timing of eating in five European countries participating in the EFCOVAL project. Methods: In this cross-sectional study, 559 men and women, aged 44–65 years, were recruited in Belgium, the Czech Republic, France (Southern part),

  5. Standard procedure of operation for the accomplishment of audit of quality in facilities of teletherapy with isotopic units of 60Co

    International Nuclear Information System (INIS)

    Larrinaga Cortina, Eduardo F.; Dominguez Hung, Lourdes; Campa Menendez, Raudel

    2001-01-01

    The use of the radiotherapy implies the necessity of rigorous quality standards in its different components, aiming to provide the best possible treatment and avoid potential patient's risks, that could even cause his/her death. Projects of technical cooperation have been developed in Cuba support by the International Atomic Energy Agency addresses to the implementation of Programs of Quality Assurance in radiotherapy services. The establishment of the National Quality Audit Program (PNAC) is a superior stage. The National Control Center for Medical Devices as the national regulator entity for the control and supervision of medical devices in the National Health System is the responsible for the making and execution of the PNAC. The audit modality selected was the inspection visit in situ due to its intrinsic advantages, our geographical extension and the number of radiotherapy services. This paper presents the methodology for the execution of the PNAC, in form of a Normalized Procedure of Operation that defines the objectives, scope, terms and definitions, responsibilities, composition and selection of the auditor team, security's conditions, materials and equipment, steps of the audit execution, results calculation and interpretation, records, etc. (author)

  6. World Health Organization 2006 Child Growth Standards and 2007 Growth Reference Charts: A Discussion Paper by the Committee on Nutrition of the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition

    DEFF Research Database (Denmark)

    Turck, Dominique; Michaelsen, Kim F.; Shamir, Raanan

    2013-01-01

    for Paediatric Gastroenterology, Hepatology, and Nutrition Committee on Nutrition is to provide information on the background and rationale of the World Health Organization (WHO) 2006 child growth standards and WHO 2007 growth reference charts, describe their development, outline their main innovative aspects......Growth charts are essential for evaluating children’s health including their nutrition; however, the evaluation of child growth trajectories and consequently the decision to intervene are highly dependent on the growth charts used. The aim of this discussion paper of the European Society...... between different countries and ethnic groups. WHO 2007 growth reference charts (5–19 years) are based mainly on a re-analysis of National Centre for Health Statistics data from 1977, without information on feeding. European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Committee...

  7. Postoperative pain medication requirements in patients undergoing computer-assisted (“Robotic”) and standard laparoscopic procedures for newly diagnosed endometrial cancer.

    Science.gov (United States)

    Leitao, Mario M; Malhotra, Vivek; Briscoe, Gabriel; Suidan, Rudy; Dholakiya, Priyal; Santos, Kevin; Jewell, Elizabeth L; Brown, Carol L; Sonoda, Yukio; Abu-Rustum, Nadeem R; Barakat, Richard R; Gardner, Ginger J

    2013-10-01

    patients who had undergone an RBT hysterectomy compared to a standard total LSC hysterectomy for benign indications.13 A recent cost analysis suggested that patients experienced less pain and required less pain medication use after RBT procedures compared to LSC for endometrial cancer.14 Based on these reports, we sought to analyze postoperative pain and the use of pain medication in patients undergoing RBT compared to standard transperitoneal LSC procedures for newly diagnosed endometrial cancer during a concurrent time period. Of note, current RBT surgery is not truly robotic in that it is not autonomous. A more appropriate term is “computer-assisted surgery,” but to satisfy current convention, we refer to it as “robotic surgery” in this manuscript.

  8. PRICE DEVELOPMENTS OF BEEF CARCASSES IN ROMANIA AND EUROPEAN UNION

    Directory of Open Access Journals (Sweden)

    IOANA BĂLAN

    2009-10-01

    Full Text Available The main objectives of the classification of cattle carcasses (beef and veal are represented by the correct payment to cattle breeders, according to carcass weight and quality, and standardization, the common language in the international meat trade. The European Union set uniform procedures for quality assessment (the EUROP system, defined by the same parameters in the whole continent. Romania is at the beginning of cattle carcass classification; it is in the third year of reporting on the classification results to the European Commission. In this context, we consider it is very important to analyze these results, for a continuous improvement of carcass quality.

  9. Standard operating procedures for collection of soil and sediment samples for the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study

    Science.gov (United States)

    Fisher, Shawn C.; Reilly, Timothy J.; Jones, Daniel K.; Benzel, William M.; Griffin, Dale W.; Loftin, Keith A.; Iwanowicz, Luke R.; Cohl, Jonathan A.

    2015-12-17

    An understanding of the effects on human and ecological health brought by major coastal storms or flooding events is typically limited because of a lack of regionally consistent baseline and trends data in locations proximal to potential contaminant sources and mitigation activities, sensitive ecosystems, and recreational facilities where exposures are probable. In an attempt to close this gap, the U.S. Geological Survey (USGS) has implemented the Sediment-bound Contaminant Resiliency and Response (SCoRR) strategy pilot study to collect regional sediment-quality data prior to and in response to future coastal storms. The standard operating procedure (SOP) detailed in this document serves as the sample-collection protocol for the SCoRR strategy by providing step-by-step instructions for site preparation, sample collection and processing, and shipping of soil and surficial sediment (for example, bed sediment, marsh sediment, or beach material). The objectives of the SCoRR strategy pilot study are (1) to create a baseline of soil-, sand-, marsh sediment-, and bed-sediment-quality data from sites located in the coastal counties from Maine to Virginia based on their potential risk of being contaminated in the event of a major coastal storm or flooding (defined as Resiliency mode); and (2) respond to major coastal storms and flooding by reoccupying select baseline sites and sampling within days of the event (defined as Response mode). For both modes, samples are collected in a consistent manner to minimize bias and maximize quality control by ensuring that all sampling personnel across the region collect, document, and process soil and sediment samples following the procedures outlined in this SOP. Samples are analyzed using four USGS-developed screening methods—inorganic geochemistry, organic geochemistry, pathogens, and biological assays—which are also outlined in this SOP. Because the SCoRR strategy employs a multi-metric approach for sample analyses, this

  10. Trueness verification of actual creatinine assays in the European market demonstrates a disappointing variability that needs substantial improvement. An international study in the framework of the EC4 creatinine standardization working group.

    Science.gov (United States)

    Delanghe, Joris R; Cobbaert, Christa; Galteau, Marie-Madeleine; Harmoinen, Aimo; Jansen, Rob; Kruse, Rolf; Laitinen, Päivi; Thienpont, Linda M; Wuyts, Birgitte; Weykamp, Cas; Panteghini, Mauro

    2008-01-01

    The European In Vitro Diagnostics (IVD) directive requires traceability to reference methods and materials of analytes. It is a task of the profession to verify the trueness of results and IVD compatibility. The results of a trueness verification study by the European Communities Confederation of Clinical Chemistry (EC4) working group on creatinine standardization are described, in which 189 European laboratories analyzed serum creatinine in a commutable serum-based material, using analytical systems from seven companies. Values were targeted using isotope dilution gas chromatography/mass spectrometry. Results were tested on their compliance to a set of three criteria: trueness, i.e., no significant bias relative to the target value, between-laboratory variation and within-laboratory variation relative to the maximum allowable error. For the lower and intermediate level, values differed significantly from the target value in the Jaffe and the dry chemistry methods. At the high level, dry chemistry yielded higher results. Between-laboratory coefficients of variation ranged from 4.37% to 8.74%. Total error budget was mainly consumed by the bias. Non-compensated Jaffe methods largely exceeded the total error budget. Best results were obtained for the enzymatic method. The dry chemistry method consumed a large part of its error budget due to calibration bias. Despite the European IVD directive and the growing needs for creatinine standardization, an unacceptable inter-laboratory variation was observed, which was mainly due to calibration differences. The calibration variation has major clinical consequences, in particular in pediatrics, where reference ranges for serum and plasma creatinine are low, and in the estimation of glomerular filtration rate.

  11. The European heir certificate

    Directory of Open Access Journals (Sweden)

    D. G. IONAŞ

    2016-11-01

    Full Text Available Opening the borders of member states and the circulation of all citizens within the European states resulted in succession procedures with foreign elements. In this context, the following question arose: which law will apply in the case of a succession procedure of a citizen who used to live in a state without having the citizenship of that state, but also when the inheritance contains goods that are located on the territory of another state? In order to unify European law and to avoid discriminatory treatment, these situations had to be regulated by a document which would apply throughout the entire European Union. That is why, starting with August 15th, 2015, The European Union enforced EU Regulation no 650 of July 4th, 20012, of the European Parliament and the Council regarding the competence, the applicable law, the acknowledgement and the execution of legal sentences and the acceptance and performance of authentic documents in regard to succession and the creation of a European heir certificate.

  12. Hospital Outcome and Risk Indices of Mortality after redo-mitral valve surgery in Potential Candidates for Transcatheter Procedures: Results From a European Registry.

    Science.gov (United States)

    Onorati, Francesco; Mariscalco, Giovanni; Reichart, Daniel; Perrotti, Andrea; Gatti, Giuseppe; De Feo, Marisa; Rubino, Antonio; Santarpino, Giuseppe; Biancari, Fausto; Detter, Christian; Santini, Francesco; Faggian, Giuseppe

    2018-04-01

    Transcatheter mitral valve-in-valve/valve-in-ring procedures (TM-VIVoR) are increasing. The authors aimed to identify independent predictors for hospital mortality in redo mitral valve surgery as possible future selection criteria for TM-VIVoR. Retrospective multicenter registry. Tertiary university and community hospitals. Two-hundred and sixty patients (out of 920 enrolled) who are potentially candidates for TM-VIVoR undergoing redo-surgery. Redo mitral surgery. Regression analyzes and receiver operating characteristic (ROC) curves identified independent predictors of death. Patients potentially candidates for TM-VIVoR reported significant hospital mortality (9.2%; EuroSCORE II: 13.2 ± 13.1, Society of Thoracic Surgeons [STS] score: 6.2 ± 3.1) and major morbidity (3.8% acute myocardial infarction, 5% stroke, 16.9% perioperative respiratory failure, 16.5% acute renal insufficiency, 25% massive transfusions). EuroSCORE II (odds ration [OR] 1.06; confidence interval [CI] 1.01-1.10; p = 0.005), STS score (OR 1.58; CI 1.27-1.97; p = 0.001), age at surgery (OR 1.05; CI 1.00-1.15; p = 0.05), preoperative dialysis (OR 2.5; CI 1.8-12.6; p = 0.042), left ventricular ejection fraction (LVEF) 13.1; 70.8% sensitivity and 68.2% specificity) and better prediction for STS score (AUC: 0.81; cut-off value: 7.4; 75.0% sensitivity and 66.2% specificity). Quintiles stratification identified EuroSCORE II ≥18.7 (5th quintile, observed mortality: 19.3%) and STS score >9.1 as strong predictors of death within each risk-categorization (OR 5.9 and 12.1, respectively). High EuroSCORE II and STS scores, advanced age at surgery, LVEF indications for TM-VIVoR in the redo-mitral surgery scenario. Copyright © 2017 Elsevier Inc. All rights reserved.

  13. Technical Note: Anatomic identification of isolated modern human molars: testing Procrustes aligned outlines as a standardization procedure for elliptic fourier analysis.

    Science.gov (United States)

    Corny, Julien; Détroit, Florent

    2014-02-01

    The determination of the precise position of permanent first and second modern human molars, following standard tooth identification criteria, is often difficult because of their morphological similarities. Here, we proposed to evaluate the suitability of two-dimensional crown contour shape analysis in achieving this objective. The method was tested separately on 180 first and second maxillary molars (UM) and 180 first and second mandibular molars (LM) securely identified (in anatomical position in their sockets). Generalized Procrustes superimposition is used to normalize the outlines prior to applying elliptic Fourier analyses ("EFAproc" method). Reliability and effectiveness of this morphometric procedure was evaluated by comparing the results obtained for the same dataset with four other morphometric methods of contour analysis. Cross-validated ("leave one individual out") percentages of misclassification yielded by linear discriminant analyses were used for determining the anatomic position of modern human molars. The percentages of misclassifications obtained from every method of contour analysis were low (1.67% to 3.33% for the UM, 5.56% to 6.67% for the LM) indicating the high suitability of crown contour analyses in correctly identifying molars. A reliable protocol, based on predictive linear discriminant analyses, was then proposed for identification of isolated molars. In addition, our results confirmed that the EFAproc method is suitable for normalizing outlines prior to undertaking elliptic Fourier analyses, especially in the case of nearly circular outlines: it obtained better classification than the classic method of normalization of Fourier descriptors for UM and provided also some advantages over the three landmarks-based methods tested here. Copyright © 2013 Wiley Periodicals, Inc.

  14. Towards an international standard for detection and typing botulinum neurotoxin-producing Clostridia types A, B, E and F in food, feed and environmental samples: a European ring trial study to evaluate a real-time PCR assay.

    Science.gov (United States)

    Fenicia, Lucia; Fach, Patrick; van Rotterdam, Bart J; Anniballi, Fabrizio; Segerman, Bo; Auricchio, Bruna; Delibato, Elisabetta; Hamidjaja, Raditijo A; Wielinga, Peter R; Woudstra, Cedric; Agren, Joakim; De Medici, Dario; Knutsson, Rickard

    2011-03-01

    A real-time PCR method for detection and typing of BoNT-producing Clostridia types A, B, E, and F was developed on the framework of the European Research Project "Biotracer". A primary evaluation was carried out using 104 strains and 17 clinical and food samples linked to botulism cases. Results showed 100% relative accuracy, 100% relative sensitivity, 100% relative specificity, and 100% selectivity (inclusivity on 73 strains and exclusivity on 31 strains) of the real-time PCR against the reference cultural method combined with the standard mouse bioassay. Furthermore, a ring trial study performed at four different European laboratories in Italy, France, the Netherlands, and Sweden was carried out using 47 strains, and 30 clinical and food samples linked to botulism cases. Results showed a concordance of 95.7% among the four laboratories. The reproducibility generated a relative standard deviation in the range of 2.18% to 13.61%. Considering the high level of agreement achieved between the laboratories, this real-time PCR is a suitable method for rapid detection and typing of BoNT-producing Clostridia in clinical, food and environmental samples and thus support the use of it as an international standard method. Copyright © 2011 Elsevier B.V. All rights reserved.

  15. Standardized MRD quantification in European ALL trials: proceedings of the Second International Symposium on MRD assessment in Kiel, Germany, 18-20 September 2008

    DEFF Research Database (Denmark)

    Brüggemann, M; Schrauder, A; Raff, T

    2010-01-01

    implementation of MRD diagnostics into clinical trials. Finally, a common terminology for a standard description of MRD response and monitoring was established defining the terms 'complete MRD response', 'MRD persistence' and 'MRD reappearance'. The proposed MRD terminology may allow a refined and standardized...

  16. Chapter 2. Surge capacity and infrastructure considerations for mass critical care. Recommendations and standard operating procedures for intensive care unit and hospital preparations for an influenza epidemic or mass disaster

    NARCIS (Netherlands)

    Hick, John L.; Christian, Michael D.; Sprung, Charles L.; Camargo, Ruben; Ceraso, Daniel; Azoulay, Elie; Duguet, Alexandre; Guery, Benoit; Reinhart, Konrad; Adini, Bruria; Barlavie, Yaron; Benin-Goren, Odeda; Cohen, Robert; Klein, Motti; Leoniv, Yuval; Margalit, Gila; Rubinovitch, Bina; Sonnenblick, Moshe; Steinberg, Avraham; Weissman, Charles; Wolff, Donna; Kesecioglu, Jozef; de Jong, Menno; Moreno, Rui; An, Youzhong; Du, Bin; Joynt, Gavin M.; Colvin, John; Loo, Shi; Richards, Guy; Artigas, Antonio; Pugin, Jerome; Amundson, Dennis; Devereaux, Asha; Beigel, John; Danis, Marion; Farmer, Chris; Maki, Dennis; Masur, Henry; Rubinson, Lewis; Sandrock, Christian; Talmor, Daniel; Truog, Robert; Zimmerman, Janice; Brett, Steve; Montgomery, Hugh; Rhodes, Andrew; Sanderson, Frances; Taylor, Bruce; Monrgomery, Hugh

    2010-01-01

    To provide recommendations and standard operating procedures for intensive care unit (ICU) and hospital preparations for a mass disaster or influenza epidemic with a specific focus on surge capacity and infrastructure considerations. Based on a literature review and expert opinion, a Delphi process

  17. Do English NHS Microbiology laboratories offer adequate services for the diagnosis of UTI in children? Healthcare Quality Improvement Partnership (HQIP) Audit of Standard Operational Procedures.

    Science.gov (United States)

    McNulty, Cliodna A M; Verlander, Neville Q; Moore, Philippa C L; Larcombe, James; Dudley, Jan; Banerjee, Jaydip; Jadresic, Lyda

    2015-09-01

    The National Institute of Care Excellence (NICE) 2007 guidance CG54, on urinary tract infection (UTI) in children, states that clinicians should use urgent microscopy and culture as the preferred method for diagnosing UTI in the hospital setting for severe illness in children under 3 years old and from the GP setting in children under 3 years old with intermediate risk of severe illness. NICE also recommends that all 'infants and children with atypical UTI (including non-Escherichia coli infections) should have renal imaging after a first infection'. We surveyed all microbiology laboratories in England with Clinical Pathology Accreditation to determine standard operating procedures (SOPs) for urgent microscopy, culture and reporting of children's urine and to ascertain whether the SOPs facilitate compliance with NICE guidance. We undertook a computer search in six microbiology laboratories in south-west England to determine urine submissions and urine reports in children under 3 years. Seventy-three per cent of laboratories (110/150) participated. Enterobacteriaceae that were not E. coli were reported only as coliforms (rather than non-E. coli coliforms) by 61% (67/110) of laboratories. Eighty-eight per cent of laboratories (97/110) provided urgent microscopy for hospital and 54% for general practice (GP) paediatric urines; 61% of laboratories (confidence interval 52-70%) cultured 1 μl volume of urine, which equates to one colony if the bacterial load is 106 c.f.u. l(-1). Only 22% (24/110) of laboratories reported non-E. coli coliforms and provided urgent microscopy for both hospital and GP childhood urines; only three laboratories also cultured a 5 μl volume of urine. Only one of six laboratories in our submission audit had a significant increase in urine submissions and urines reported from children less than 3 years old between the predicted pre-2007 level in the absence of guidance and the 2008 level following publication of the NICE guidance. Less than a

  18. European Union air quality standards for benzene. The first European Union limiting value for a carcinogenic material in the outside air; EU-luchtkwaliteitseisen voor benzeen. De eerste EU-limietwaarde voor een carcinogene stof in de buitenlucht

    Energy Technology Data Exchange (ETDEWEB)

    Tordoir, W.F. [Shell International, The Hague (Netherlands)

    1999-06-01

    On 2nd December 1998, the European Commission has adopted a proposal for a Council Directive relating to limit values for benzene and carbon monoxide in ambient air. The work of a working group, assisted by an ad-hoc group of health experts, involved in the development of a Limit Value for benzene is described. The WHO-EUR advice on an air quality guideline for benzene was taken as a basis, but appeared not workable if, as a starting point for risk assessment, an additional risk of one in a million persons exposed for life, is taken. Two other, less conservative, risk assessments were taken into consideration. One was prepared by CONCAWE, the other by the Netherlands Health Council. As a result, the highest and the lowest plausible risk estimates were identified as 5x10{sup -6} and 5x10{sup -8} respectively, which equals a range of concentrations of 0.2-20 {mu}g/m{sup 3} with a lifetime risk of one in a million. A cost-benefit study, carried out by a consultant, indicated that only in the best scenario costs and benefits will be about in balance in hot spots by 2010 when the Limit Value is set at 10 {mu}g/m{sup 3}, but that the costs of legislation additional to current and `in the pipeline` regulations will significantly exceed the benefits in hot spots by 2010 when the Limit Value is set at 5 {mu}g/m{sup 3}. Having considered the views of the working group for benzene and the steering group on Air Quality, the Commission decided to propose a Limit Value of 5 {mu}g/m{sup 3} to be achieved in 2010, with a Margin of Tolerance of 5 {mu}g/m{sup 3}. A review will be held in 2004 and derogations may be granted until 2015. Many hurdles still have to be taken before the proposal reaches the Council of Ministers where it will be voted upon. 5 refs.

  19. European Whiteness?

    DEFF Research Database (Denmark)

    Blaagaard, Bolette

    2008-01-01

    Born out of the United States’ (U.S.) history of slavery and segregation and intertwined with gender studies and feminism, the field of critical whiteness studies does not fit easily into a European setting and the particular historical context that entails. In order for a field of European...

  20. European Institutions?

    NARCIS (Netherlands)

    Meacham, Darian

    2016-01-01

    The aim of this article is to sketch a phenomenological theory of political institutions and to apply it to some objections and questions raised by Pierre Manent about the project of the European Union and more specifically the question of “European Construction”, i.e. what is the aim of the