The CoRoT Exoplanet program: status & results

Directory of Open Access Journals (Sweden)

Moutou C.

2011-02-01

Full Text Available The CoRoT satellite is the first instrument hunting for planets from space. We will review the status of the CoRoT/Exoplanet program. We will then present the CoRoT exoplanetary systems and how they widen the range of properties of the close-in population and contribute to our understanding of the properties of planets.

Haitilased süüdistavad kooleras ÜRO rahuvalvajaid

Index Scriptorium Estoniae

2010-01-01

Paljud kohalikud elanikud on veendunud, et Haiti kooleraepideemia vallandamises on süüdi ÜRO stabilisatsioonimission MINUSTAH. Riigis on puhkenud ÜRO-vastased rahutused. ÜRO arvates on protestilaine algatatud presidendivalimisi nurjata soovivate poliitiliste liikumiste poolt

Ku-pa-ro en las tablillas de Cnoso

Directory of Open Access Journals (Sweden)

José L. Melena

1974-12-01

Full Text Available This paper is intended to be a comprehensive analysis of the evidence of ku-pa-ro in the Knossos Linear B tablets. Its main purpose is to set up the importance of such aromatic plant in the Mycenaean economy at Knossos and to identify what kind of sedge was concealed under the name ku-pa-ro and what part of the plant was used and for what purposes. What it is stressed is the usage of the Cyperus rotundus L. (i. e. the ku-pa-ro in the industry of perfumes and as a food additive as well. What is inferred from the discussion on the evidence of ku-pa-ro issues a series of valuable data concerning the localization of certain place-names in the map of Crete, and concerning the explanation of ideogram *171. The high qualities of ku-pa-ro preserved in the tablets lead the author to assume that such a plant was cultivated in Crete and was one of the main aromatic plants used by the Mycenaeans in the making of perfumes.

Short Review on Predicting Fouling in RO Desalination

Directory of Open Access Journals (Sweden)

Alejandro Ruiz-García

2017-10-01

Full Text Available Reverse Osmosis (RO membrane fouling is one of the main challenges that membrane manufactures, the scientific community and industry professionals have to deal with. The consequences of this inevitable phenomenon have a negative effect on the performance of the desalination system. Predicting fouling in RO systems is key to evaluating the long-term operating conditions and costs. Much research has been done on fouling indices, methods, techniques and prediction models to estimate the influence of fouling on the performance of RO systems. This paper offers a short review evaluating the state of industry knowledge in the development of fouling indices and models in membrane systems for desalination in terms of use and applicability. Despite major efforts in this field, there are gaps in terms of effective methods and models for the estimation of fouling in full-scale RO desalination plants. In existing models applied to full-scale RO desalination plants, neither the spacer geometry of membranes, nor the efficiency and frequency of chemical cleanings are considered.

RO-PRO desalination: An integrated low-energy approach to seawater desalination

International Nuclear Information System (INIS)

Prante, Jeri L.; Ruskowitz, Jeffrey A.; Childress, Amy E.; Achilli, Andrea

2014-01-01

Highlights: • In the novel RO-PRO system, the energy produced by PRO is utilized to offset the energy consumed by the RO. • The specific energy consumption of a RO-PRO system was modeled for the first time. • A novel module-based PRO model for full-scale applications was developed. • The minimum net specific energy consumption of the modeled RO-PRO system was 1.2 kW h/m 3 at 50% RO recovery. • A sensitivity analysis showed a min RO-PRO specific energy consumption of 1.0 kW h/m 3 and a max power density of 10 W/m 2 . - Abstract: Although reverse osmosis (RO) is currently the most energy efficient desalination technology, it still requires a great deal of energy to create the high pressures necessary to desalinate seawater. An opposite process of RO, called pressure retarded osmosis (PRO), utilizes the salinity gradient between a relatively fresh impaired water source and seawater to produce pressure and hence, energy. In this paper, PRO is evaluated in conjunction with RO, in a system called RO-PRO desalination, to reduce the energy requirement of seawater RO desalination. RO-PRO specific energy consumption was modeled using RO conditions at the thermodynamic restriction and a newly developed module-based PRO model. Using a well-characterized cellulose triacetate (CTA) membrane, the minimum net specific energy consumption of the system was found to be approximately 40% lower than state-of-the-art seawater RO. A sensitivity analysis was performed to determine the effects of membrane characteristics on the specific energy production of the PRO process in the RO-PRO system. The sensitivity analysis showed that the minimum specific energy consumption using virtual membranes is approximately 1.0 kW h per m 3 of RO permeate at 50% RO recovery and that a maximum power density of approximately 10 W/m 2 could be achieved

SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

Energy Technology Data Exchange (ETDEWEB)

Jauharoh, Siti Nur Aisyah [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Faculty of Medicine and Health Science, Syarif Hidayatullah State Islamic University, Jakarta 15412 (Indonesia); Saegusa, Jun; Sugimoto, Takeshi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Ardianto, Bambang [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Child Health, Faculty of Medicine, Gadjah Mada University, Yogyakarta 55282 (Indonesia); Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Tokuno, Osamu; Nakamachi, Yuji [Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan); Kumagai, Shunichi [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Kawano, Seiji, E-mail: sjkawano@med.kobe-u.ac.jp [Department of Clinical Pathology and Immunology, Kobe University Graduate School of Medicine, Hyogo 650-0017 (Japan); Department of Laboratory Medicine, Kobe University Hospital, Hyogo 650-0017 (Japan)

2012-01-06

Highlights: Black-Right-Pointing-Pointer Ro52{sup low} HeLa cells are resistant to apoptosis upon various stimulations. Black-Right-Pointing-Pointer Ro52 is upregulated by IFN-{alpha}, etoposide, or IFN-{gamma} and anti-Fas Ab. Black-Right-Pointing-Pointer Ro52-mediated apoptosis is independent of p53. Black-Right-Pointing-Pointer Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjoegren's syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52's role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52{sup low} HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H{sub 2}O{sub 2}- or diamide-induced oxidative stress, IFN-{alpha}, IFN-{gamma} and anti-Fas antibody, etoposide, or {gamma}-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

SS-A/Ro52 promotes apoptosis by regulating Bcl-2 production

International Nuclear Information System (INIS)

Jauharoh, Siti Nur Aisyah; Saegusa, Jun; Sugimoto, Takeshi; Ardianto, Bambang; Kasagi, Shimpei; Sugiyama, Daisuke; Kurimoto, Chiyo; Tokuno, Osamu; Nakamachi, Yuji; Kumagai, Shunichi; Kawano, Seiji

2012-01-01

Highlights: ► Ro52 low HeLa cells are resistant to apoptosis upon various stimulations. ► Ro52 is upregulated by IFN-α, etoposide, or IFN-γ and anti-Fas Ab. ► Ro52-mediated apoptosis is independent of p53. ► Ro52 selectively regulates Bcl-2 expression. -- Abstract: SS-A/Ro52 (Ro52), an autoantigen in systemic autoimmune diseases such as systemic lupus erythematosus and Sjögren’s syndrome, has E3 ligase activity to ubiquitinate proteins that protect against viral infection. To investigate Ro52’s role during stress, we transiently knocked it down in HeLa cells by siRo52 transfection. We found that Ro52 low HeLa cells were significantly more resistant to apoptosis than wild-type HeLa cells when stimulated by H 2 O 2 - or diamide-induced oxidative stress, IFN-α, IFN-γ and anti-Fas antibody, etoposide, or γ-irradiation. Furthermore, Ro52-mediated apoptosis was not influenced by p53 protein level in HeLa cells. Depleting Ro52 in HeLa cells caused Bcl-2, but not other Bcl-2 family molecules, to be upregulated. Taken together, our data showed that Ro52 is a universal proapoptotic molecule, and that its proapoptotic effect does not depend on p53, but is exerted through negative regulation of the anti-apoptotic protein Bcl-2. These findings shed light on a new physiological role for Ro52 that is important to intracellular immunity.

Transiting exoplanets from the CoRoT space mission. XVII. The hot Jupiter CoRoT-17b: a very old planet

Science.gov (United States)

Csizmadia, Sz.; Moutou, C.; Deleuil, M.; Cabrera, J.; Fridlund, M.; Gandolfi, D.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Bruntt, H.; Carone, L.; Carpano, S.; Cavarroc, C.; Cochran, W.; Deeg, H. J.; Díaz, R. F.; Dvorak, R.; Endl, M.; Erikson, A.; Ferraz-Mello, S.; Fruth, Th.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jehin, E.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; MacQueen, P. J.; Mazeh, T.; Ollivier, M.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

2011-07-01

We report on the discovery of a hot Jupiter-type exoplanet, CoRoT-17b, detected by the CoRoT satellite. It has a mass of 2.43 ± 0.30 MJup and a radius of 1.02 ± 0.07 RJup, while its mean density is 2.82 ± 0.38 g/cm3. CoRoT-17b is in a circular orbit with a period of 3.7681 ± 0.0003 days. The host star is an old (10.7 ± 1.0 Gyr) main-sequence star, which makes it an intriguing object for planetary evolution studies. The planet's internal composition is not well constrained and can range from pure H/He to one that can contain ~380 earth masses of heavier elements. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W.M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W.M. Keck Foundation.

CoRoT’s first seven planets: An overview*

Directory of Open Access Journals (Sweden)

Barge P.

2011-07-01

Full Text Available The up to 150 day uninterrupted high-precision photometry of about 100000 stars – provided so far by the exoplanet channel of the CoRoT space telescope – gave a new perspective on the planet population of our galactic neighbourhood. The seven planets with very accurate parameters widen the range of known planet properties in almost any respect. Giant planets have been detected at low metallicity, rapidly rotating and active, spotted stars. CoRoT-3 populated the brown dwarf desert and closed the gap of measured physical properties between standard giant planets and very low mass stars. CoRoT extended the known range of planet masses down-to 5 Earth masses and up to 21 Jupiter masses, the radii to less than 2 Earth radii and up to the most inflated hot Jupiter found so far, and the periods of planets discovered by transits to 9 days. Two CoRoT planets have host stars with the lowest content of heavy elements known to show a transit hinting towards a different planet-host-star-metallicity relation then the one found by radial-velocity search programs. Finally the properties of the CoRoT-7b prove that terrestrial planets with a density close to Earth exist outside the Solar System. The detection of the secondary transit of CoRoT-1 at the 10−5-level and the very clear detection of the 1.7 Earth radii of CoRoT-7b at 3.5 10−4 relative flux are promising evidence of CoRoT being able to detect even smaller, Earth sized planets.

Techno-economic investigation of alternative propulsion plants for Ferries and RoRo ships

International Nuclear Information System (INIS)

Livanos, George A.; Theotokatos, Gerasimos; Pagonis, Dimitrios-Nikolaos

2014-01-01

Highlights: • Alternative Diesel and Gas engine propulsion plants of Ferries and RoRos were studied. • Special focus on marine Natural Gas burning engines and ship waste heat recovery systems. • Significant savings in annual operating costs were predicted in the case of Natural Gas engines. • Environmental and economic optimum propulsion plant alternative was proposed in a specific case study. - Abstract: In this paper, the main alternative propulsion plants based on reciprocating internal combustion engines of a ferry or RoRo ship operating in routes that include Emission Control Areas (ECAs) are comparatively assessed. Specifically, a dual fuel engine propulsion plant is compared with a conventional Diesel engine plant. For both cases, the installation of a waste heat recovery system, which covers a part of the ship electric energy demand, is also considered. The ship main DF engines are assumed to operate using LNG and a small amount of MDO for initiating combustion, whereas low sulphur MDO was regarded as the fuel for the case of the Diesel engine plant. The installation of Selective Catalytic Reduction (SCR) after-treatment unit for reducing the NOx emissions for the case of Diesel engines plant is also taken into account. The propulsion plants were modelled under steady state conditions, and the simulation results were analysed in order to compare the alternative configurations. Furthermore, the Energy Efficiency Design Index (EEDI) values were calculated and the two examined propulsion system cases were compared on EEDI basis. Finally, the Life Cycle Cost for each alternative propulsion plant was calculated and used for completing an economic evaluation of the Dual fuel propulsion plant versus the conventional designs applied in ferries

The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799

International Nuclear Information System (INIS)

Walton, M.I.; Bleehen, N.M.; Workman, P.; Cambridge Univ.

1985-01-01

The nitroimidazole radiosensitizer Ro 03-8799 and the N-oxide Ro 31-0313 were dissolved in buffered solution and given i.v. to inbred male mice. Drug concentrations in whole blood, blood plasma and urine were determined by MPLC. Ro 03 8799 is rapidly cleared and extensively metabolised. Ro 31-0313 is reduced back to Ro 03-8799 by whole blood. The pharmacological and toxicological consequences of this are unknown. (UK)

The feasibility of nanofiltration membrane bioreactor (NF-MBR)+reverse osmosis (RO) process for water reclamation: Comparison with ultrafiltration membrane bioreactor (UF-MBR)+RO process.

Science.gov (United States)

Tay, Ming Feng; Liu, Chang; Cornelissen, Emile R; Wu, Bing; Chong, Tzyy Haur

2018-02-01

This study examines the feasibility of a novel nanofiltration membrane bioreactor (NF-MBR) followed by reverse osmosis (RO) process for water reclamation at 90% recovery and using an ultrafiltration MBR (UF-MBR)+RO as baseline for comparison. Both MBRs adopted the same external hollow fiber membrane configurations and operating conditions. The collected permeates of the MBRs were subsequently fed to the respective RO systems. The results showed that the NF-MBR (operated at a constant flux of 10 L/m 2 h) achieved superior MBR permeate quality due to enhanced biodegradation and high rejection capacity of the NF membrane, leading to lower RO fouling rates (∼3.3 times) as compared to the UF-MBR. Further analysis indicated that the cake layer fouling that caused the cake-enhanced osmotic pressure (CEOP) effect contributed predominantly to the transmembrane pressure (TMP) increase in the NF-MBR, while irreversible pore fouling was the major reason for UF membrane fouling. Furthermore, it was found that the biopolymers (i.e., organics with MW > 10 kDa) were the main components present in the foulants of the NF/UF membranes and RO membranes. The analysis indicated that the NF-MBR + RO system at recovery of 90% has comparable energy consumption as the UF-MBR + RO system at recovery of 75%. Our findings proved the feasibility of the NF-MBR + RO for water reclamation at a high recovery rate. Copyright © 2017 Elsevier Ltd. All rights reserved.

Konstruiranje ročaja hidravličnih klešč

OpenAIRE

Žižek, Tomaž

2015-01-01

V diplomskem delu je opisan potek konstruiranja ročaja hidravličnih klešč za odstranjevanje ločnega podporja v Premogovniku Velenje. Predstavljeni so vsi pomembnejši koraki, in sicer modeliranje klešč, modeliranje ročaja, numerični rezultati, izbira najustreznejše oblike ročaja ter predstavitev rezultatov ustreznega modela. Diplomsko delo zajema tudi izbiro ustreznega materiala, postopek izdelave ter podatke za pravilno varjenje ročaja na ohišje klešč. Numerični preračuni so opravljeni v pro...

Detection of small-size planetary candidates with CoRoT data

Directory of Open Access Journals (Sweden)

Moutou C.

2011-02-01

Full Text Available With the discovery of CoRoT-7b, the first transiting super-Earth, the CoRoT space mission has shown the capability to detect short-period rocky planets around solar-like stars. By performing a blind test with real CoRoT light curves, we want to establish the detection threshold of small-size planets in CoRoT data. We investigate the main obstacles to the detection of transiting super-Earths in CoRoT data, notably the presence of short-time scale variability and hot pixels.

USA uus ÜRO saadik alustas pealetungi / Neeme Raud

Index Scriptorium Estoniae

Raud, Neeme, 1969-

2005-01-01

Ameerika Ühendriikide uus ÜRO suursaadik John Bolton nõuab 190 liikmesriigile saadetud kirjas ÜRO reformikavades suurte ja oluliste muudatuste tegemist: reformikavast peaks USA arvates kustutama vähemalt 400 paragrahvi

Ilves osaleb ÜRO Peaassamblee 62. istungjärgul

Index Scriptorium Estoniae

2007-01-01

President Toomas Hendrik Ilves osaleb New Yorgis ÜRO peaassamblee 62. istungjärgu töös. Eesti riigipea osaleb ka ÜRO korraldatud kliimamuutuste konverentsil, kohtub ÜRO peasekretäri ja Makedoonia, Slovakkia ning Bosnia ja Hertsegoviina presidendiga, samuti filantroop George Sorosega ning osaleb Baltimaade riigipeade kohtumisel. T.H. Ilves külastab ka Columbia Ülikooli ning osaleb New Yorgi Eesti haridusseltsi korraldatud vastuvõtul New Yorgi Eesti Majas. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

The Dushak–Erekdag Survey of roAp Stars

Indian Academy of Sciences (India)

2016-01-27

Jan 27, 2016 ... The search of roAp stars at Mt. Dushak–Erekdag Observatory was started in 1992 using the 0.8m Odessa telescope equipped with a two-star high-speed photometer. We have observed more than a dozen stars so far and discovered HD 99563 as roAp star while BD+8087 is suspected to have rapid ...

Radiosensitization of mouse spermatogenic stem cells by Ro-07-0582

International Nuclear Information System (INIS)

Suzuki, N.; Withers, R.; Hunter, N.

1977-01-01

The hypoxic character of the spermatogenic stem cells of the mouse testis was investigated by measuring the effect on radiosensitivity of treatment with the hypoxic cell radiosensitizer, Ro-07-0582 or hyperbaric oxygen (30 psi). The D 0 values obtained were 181 (161-207) rad for irradiation alone, 140 (133-148) rad for irradiation after treatment with Ro-07-0582, and about 100 rad for irradiation in the presence of hyperbaric oxygen. Ro-07-0582 alone was slightly cytotoxic. The results demonstrate that mouse spermatogenic stem cells are radiosensitized by Ro-07-0582 or hyperbaric oxygen and are not as well oxygenated as other normal tissues

RoMPS concept review automatic control of space robot

Science.gov (United States)

1991-01-01

The Robot operated Material Processing in Space (RoMPS) experiment is being performed to explore the marriage of two emerging space commercialization technologies: materials processing in microgravity and robotics. This concept review presents engineering drawings and limited technical descriptions of the RoMPS programs' electrical and software systems.

News Agency Website Agenda on Religion. Comparative Analysis on Mediafax.ro and Agerpres.ro

Directory of Open Access Journals (Sweden)

Aurelia Ana Vasile

2016-06-01

Full Text Available According to the “Global Index of Religiosity and Atheism” (WIN-Gallup International, 27 July 2012, retrieved 24 August 2012, which was a global 2012 poll, the reports label 59% of the world's population as “religious” and 36% as not religious, including 13% who are atheists, with a 9% decrease in religious belief from 2005. Thereto, religion is an important issue of inherent influence in the media nowadays. Despite the ongoing secularization process that we are facing these days, humans still feel the need to refer to religion within their attempt to construct one’s own outlook on life, and to make some sense out of existence in general (Max Weber, 19202. A comparative content analysis on Mediafax.ro and Agerpres.ro, performed for an almost nine-and-a-half-month time span (1st January to 13th October 2015, showed interesting facts on how press agency journalists relate to religion as a media topic, both in terms of quality (key words and key topics and in terms of quantity. A comparison between the Orthodox religion of the majority of the Romanians, and other denominations, also accounted for intriguing research findings.

Evaluation of RO modules for the SSP ETC/LSS.

Science.gov (United States)

Jasionowski, W. J.; Bambenek, R. A.

1973-01-01

During the past eight years the NASA Manned Spacecraft Center has supported the development of an Integrated Water and Waste Management System for use in the Space Station Prototype (SSP) Environmental Thermal Control/Life-Support System (ETC/LSS). This system includes the reverse osmosis (RO) process for recycling wash water and the compression distillation process for recovering useable water from urine, urinal flush water, humidity condensate, commode flush water and the wash water concentrated by RO. This paper summarizes the experimental work performed during the past four years to select the best commercially available RO module for this system and to also define which surfactants and germicides are most compatible with the selected module.

Planetary transit candidates in CoRoT LRa01 field

DEFF Research Database (Denmark)

Carone, L.; Gandolfi, D.; Cabrera, J.

2012-01-01

We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. We acquired and analyzed 7470 chromatic and 3938 monochromatic...... lightcurves. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. (2 data files)....

Validation of Robotic Surgery Simulator (RoSS).

Science.gov (United States)

Kesavadas, Thenkurussi; Stegemann, Andrew; Sathyaseelan, Gughan; Chowriappa, Ashirwad; Srimathveeravalli, Govindarajan; Seixas-Mikelus, Stéfanie; Chandrasekhar, Rameella; Wilding, Gregory; Guru, Khurshid

2011-01-01

Recent growth of daVinci Robotic Surgical System as a minimally invasive surgery tool has led to a call for better training of future surgeons. In this paper, a new virtual reality simulator, called RoSS is presented. Initial results from two studies - face and content validity, are very encouraging. 90% of the cohort of expert robotic surgeons felt that the simulator was excellent or somewhat close to the touch and feel of the daVinci console. Content validity of the simulator received 90% approval in some cases. These studies demonstrate that RoSS has the potential of becoming an important training tool for the daVinci surgical robot.

Cuentos ashaninka del r??o Peren??

OpenAIRE

Plasencia Soto, Rommel; S??nchez V??squez, Melisa

2009-01-01

La memoria ind??gena de los pueblos amaz??nicos del Per?? de hoy, es mostrada en cuatro relatos registrados en la comunidad de Mariscal C??ceres en el valle del r??o Peren?? de la selva central peruana.

Coupling of RO-MSF hybrid desalination plants with nuclear reactors

International Nuclear Information System (INIS)

Al-Sulaiman, Khalil; Al-Mutaz, Ibrahim S.

1999-01-01

Full text.Reverse osmosis (RO) and multistage flash (MSF) desalination are the most widely commercial available processes. MSF utilizes stream in the brine heater as a primary source of energy. RO is derived mainly by electricity that pumps the feed water against the mambranes. Steam and electricity and be produced easily by nuclear reactors. Nuclear reactors may be coupled with deslination plants (MSF, RO or combined (hybrid) RO/MSF configuration). This integrated plant will be capable of producing power and water at reasonable cost. The capital and operating cost will be reduced and the excess power can be efficiently utilized. Maintenance and operating cost will drop significantly. In this paper, a techno-economic study of hybrid reverses osmosis /multistage flash desalination will be carried. The proposed configuration (hybrid RO/MSF) coupled with nuclear reactor is considered the most appropriate candidate system for the application of dual-purpose nuclear desalination plants. the design parameters for such a desalination hybrid system will be the applied pressure and recovery for reverse osmosis plant and the number of stages and the heat transfer areas for multistage flash plant

Douglas R.O. Morrison

CERN Multimedia

2001-01-01

Douglas R.O. Morrison 1929 - 2001 Douglas' friends and colleagues are warmly invited to join in a memorial gathering on Friday, 23 March 2001 at 16.00 hours in the CERN Main Auditorium Some colleagues will pay tribute to Douglas' scientific achievements and to his role in leading the collaborations:   Welcome, short CV The 'hadron times' The 'neutrino times' Recent activities Collaborations The 'social environment' A book of condolence will be available. The gathering will conclude with refreshments in the Salle des Pas Perdus.

Sõjaraport õõnestab ÜRO usaldusväärsust / Jürgen Tamme

Index Scriptorium Estoniae

Tamme, Jürgen

2011-01-01

ÜRO Gaza sõda puudutavas raportis kritiseeritakse nii Iisraeli kui ka Palestiina islamistlikku äärmusrühmitust Hamas. ÜRO inimõiguste uurija Richard Goldstone leiab, et raport on siiski puudulik, kuna praegu omab ÜRO juba rohkem infot Gaza sõja kohta

Fellow's Apéro

CERN Multimedia

Staff Association

2017-01-01

Let's get together, meet each other, exchange experiences and ideas, and share useful information on CERN and the Staff Association. Join us for Fellow's Apéro, organised by the Staff Association on Tuesday 21 February at 16.30 in Restaurant 1. There will be drinks and snacks for everybody! We look forward to seeing you there! Please confirm your participation on Doodle http://doodle.com/poll/skvm7ucm2z78i6bt or alternatively on Facebook https://www.facebook.com/events/1862757017340069/. Your delegates in the Staff Association, Barbora & Jiri

Clinical and Pathological Roles of Ro/SSA Autoantibody System

Directory of Open Access Journals (Sweden)

Ryusuke Yoshimi

2012-01-01

Full Text Available Anti-Ro/SSA antibodies are among the most frequently detected autoantibodies against extractable nuclear antigens and have been associated with systemic lupus erythematosus (SLE and Sjögren's syndrome (SS. Although the presence of these autoantibodies is one of the criteria for the diagnosis and classification of SS, they are also sometimes seen in other systemic autoimmune diseases. In the last few decades, the knowledge of the prevalence of anti-Ro/SSA antibodies in various autoimmune diseases and symptoms has been expanded, and the clinical importance of these antibodies is increasing. Nonetheless, the pathological role of the antibodies is still poorly understood. In this paper, we summarize the milestones of the anti-Ro/SSA autoantibody system and provide new insights into the association between the autoantibodies and the pathogenesis of autoimmune diseases.

Expression of BAFF receptors in muscle tissue of myositis patients with anti-Jo-1 or anti-Ro52/anti-Ro60 autoantibodies.

Science.gov (United States)

Kryštůfková, Olga; Barbasso Helmers, Sevim; Venalis, Paulius; Malmström, Vivianne; Lindroos, Eva; Vencovský, Jiří; Lundberg, Ingrid E

2014-10-10

Anti-Jo-1 and anti-Ro52 autoantibodies are common in patients with myositis, but the mechanisms behind their production are not known. Survival of autoantibody-producing cells is dependent on B-cell-activating factor of the tumour necrosis factor family (BAFF). BAFF levels are elevated in serum of anti-Jo-1-positive myositis patients and are influenced by type-I interferon (IFN). IFN-producing cells and BAFF mRNA expression are present in myositis muscle. We investigated expression of the receptors for BAFF in muscle tissue in relation to anti-Jo-1 and anti-Ro52/anti-Ro60 autoantibodies and type-I IFN markers. Muscle biopsies from 23 patients with myositis selected based on autoantibody profile and 7 healthy controls were investigated for expression of BAFF receptor (BAFF-R), B-cell maturation antigen (BCMA) and transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI). Nineteen samples were assessed for plasma (CD138) and B-cell (CD19) markers. The numbers of positive cells per area were compared with the expression of plasmacytoid dendritic cell (pDC) marker blood dendritic cell antigen-2 (BDCA-2) and IFNα/β-inducible myxovirus resistance-1 protein (MX-1). BAFF-R, BCMA and TACI were expressed in five, seven and seven patients, respectively, and more frequently in anti-Jo-1-positive and/or anti-Ro52/anti-Ro60-positive patients compared to controls and to patients without these autoantibodies (P = BAFF-R: 0.007, BCMA: 0.03 and TACI: 0.07). A local association of receptors with B and plasma cells was confirmed by confocal microscopy. The numbers of CD138-positive and BCMA-positive cells were correlated (r = 0.79; P = 0.001). Expression of BDCA-2 correlated with numbers of CD138-positive cells and marginally with BCMA-positive cells (r = 0.54 and 0.42, respectively; P = 0.04 and 0.06, respectively). There was a borderline correlation between the numbers of positively stained TACI cells and MX-1 areas (r = 0.38, P = 0.08). The expression

[The life of Dr. RO Kishun, a reflection of modern Korean medical history of the borders].

Science.gov (United States)

Shin, Young-Jeon; Park, Se-Hong

2009-06-01

RO Kishun was born on February 2, 1893 in Ongjin County, Hwanghae Province of Joseon Korea. He graduated from the Medical Training Center, a campus associated with the Joseon Government-General Hospital, in 1915, and from Kyushu Imperial University School of Medicine in 1917. He continued his medical study at the university in 1929, majoring in biochemistry, and earned a doctorate in medicine in 1932. Dr. RO, one of the earliest pioneers in Korean biochemistry, was active in his research, publishing four studies in the Japanese Journal of Biochemistry between 1931 and 1932. After returning from Japan in 1932, Dr. RO opened a medical practice in Mokpo and Busan, port cities situated on the southern tip of Korea. Later in 1936, he moved north to Manchuria (northeast China) to practice medicine at the International Hospital in Mukden (present-day Shenyang). He also served as president of Tumen Public Hospital between 1942 and 1946. When Japan signed unconditional surrender bringing World War II to an end, Dr. RO relocated to Yanbian and began providing medical training to ethnic Koreans. In October 1946, he was appointed dean of the First Branch School of China Medical University in Longjing, and in October 1948 the first dean of Yanbian Medical School, the predecessor of Yanbian University College of Medicine. Dr. RO dedicated his life to medical practice, teaching and training students, and mentoring younger faculty. A brilliant clinician, he also inspired and helped his colleagues with his outstanding ability to diagnose and treat patients. He was one of the founding members of Yanbian University College of Medicine. RO Kishun died on June 7, 1957 at age 64. Ethnic Koreans hailed him as Sinui (literally, the physician of God), and a bronze statue of himself was erected in front of the medical college in 1988. Dr. RO's life brings modern historians' attention to the issue of determining geographical territories and nationality, in that his life unfolded at the

Impact of RO-desalted water on distribution water qualities.

Science.gov (United States)

Taylor, J; Dietz, J; Randall, A; Hong, S

2005-01-01

A large-scale pilot distribution study was conducted to investigate the impacts of blending different source waters on distribution water qualities, with an emphasis on metal release (i.e. corrosion). The principal source waters investigated were conventionally treated ground water (G1), surface water processed by enhanced treatment (S1), and desalted seawater by reverse osmosis membranes (RO). Due to the nature of raw water quality and associated treatment processes, G1 water had high alkalinity, while S1 and RO sources were characterized as high sulfate and high chloride waters, respectively. The blending ratio of different treated waters determined the quality of finished waters. Iron release from aged cast iron pipes increased significantly when exposed to RO and S1 waters: that is, the greater iron release was experienced with alkalinity reduced below the background of G1 water. Copper release to drinking water, however, increased with increasing alkalinity and decreasing pH. Lead release, on the other hand, increased with increasing chloride and decreasing sulfate. The effect of pH and alkalinity on lead release was not clearly observed from pilot blending study. The flat and compact corrosion scales observed for lead surface exposed to S1 water may be attributable to lead concentration less than that of RO water blends.

ÜRO rahuvalvemissiooni juhtinud brasiillane leiti Haiti hotellist surnult / Heiki Suurkask

Index Scriptorium Estoniae

Suurkask, Heiki, 1972-

2006-01-01

ÜRO Haiti rahuvalvemissiooni juht Urano Teixeira da Matta Bacellar sooritas enesetapu. ÜRO rahuvalvemissioon MINUSTAH on Haitil 2005. aastast pärast nelja-aastast eemalolekut, samas jätkub seal vägivald

The Dushak–Erekdag Survey of roAp Stars Tatyana Dorokhova ...

Indian Academy of Sciences (India)

South-African Astronomical Observatory (SAAO). Details of the discovery and further studies are given in Kurtz (1990) and Kurtz & Martinez (2000). Some roAp stars have multiple modes of pulsations and they are valuable for asteroseismological studies. Out of the 32 known roAp stars so far, about 84% were discovered in ...

Transiting exoplanets from the CoRoT space mission . VI. CoRoT-Exo-3b: the first secure inhabitant of the brown-dwarf desert

Science.gov (United States)

Deleuil, M.; Deeg, H. J.; Alonso, R.; Bouchy, F.; Rouan, D.; Auvergne, M.; Baglin, A.; Aigrain, S.; Almenara, J. M.; Barbieri, M.; Barge, P.; Bruntt, H.; Bordé, P.; Collier Cameron, A.; Csizmadia, Sz.; de La Reza, R.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gandolfi, D.; Gillon, M.; Guenther, E.; Guillot, T.; Hatzes, A.; Hébrard, G.; Jorda, L.; Lammer, H.; Léger, A.; Llebaria, A.; Loeillet, B.; Mayor, M.; Mazeh, T.; Moutou, C.; Ollivier, M.; Pätzold, M.; Pont, F.; Queloz, D.; Rauer, H.; Schneider, J.; Shporer, A.; Wuchterl, G.; Zucker, S.

2008-12-01

Context: The CoRoT space mission routinely provides high-precision photometric measurements of thousands of stars that have been continuously observed for months. Aims: The discovery and characterization of the first very massive transiting planetary companion with a short orbital period is reported. Methods: A series of 34 transits was detected in the CoRoT light curve of an F3V star, observed from May to October 2007 for 152 days. The radius was accurately determined and the mass derived for this new transiting, thanks to the combined analysis of the light curve and complementary ground-based observations: high-precision radial-velocity measurements, on-off photometry, and high signal-to-noise spectroscopic observations. Results: CoRoT-Exo-3b has a radius of 1.01 ± 0.07 R_Jup and transits around its F3-type primary every 4.26 days in a synchronous orbit. Its mass of 21.66 ± 1.0 M_Jup, density of 26.4 ± 5.6 g cm-3, and surface gravity of logg = 4.72 clearly distinguish it from the regular close-in planet population, making it the most intriguing transiting substellar object discovered so far. Conclusions: With the current data, the nature of CoRoT-Exo-3b is ambiguous, as it could either be a low-mass brown-dwarf or a member of a new class of “superplanets”. Its discovery may help constrain the evolution of close-in planets and brown-dwarfs better. Finally, CoRoT-Exo-3b confirms the trend that massive transiting giant planets (M ≥ 4 M_Jup) are found preferentially around more massive stars than the Sun. The CoRoT space mission, launched on December 27th 2006, has been developed and is operating by CNES, with the contribution of Austria, Belgium, Brasil, ESA, Germany and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Table of the COROT photometry is only available in electronic form at the CDS via anonymous ftp to cdsarc.u-strasbg.fr (130.79.128.5) or via http

High-efficient full-duplex WDM-RoF system with sub-central station

Science.gov (United States)

Liu, Anliang; Yin, Hongxi; Wu, Bin

2018-05-01

With an additional sub-central station (S-CS), a high-efficient full-duplex radio-over-fiber (RoF) system compatible with the wavelength-division-multiplexing technology is proposed and experimentally demonstrated in this paper. To improve the dispersion tolerance of the RoF system, the baseband data format for the downlink and an all-optical down-conversion approach for the uplink are employed. In addition, this RoF system can not only make full use of the fiber link resources but also realize the upstream transmission without any local light sources at remote base stations (BSs). A 10-GHz RoF experimental system with a 1.25-Gb/s rate bidirectional transmission is established based on the S-CS structure. The feasibility and reliability of this RoF system are verified through eye diagrams and bit error rate (BER) curves experimentally obtained.

[Expression and clinical significance of CD45RO in laryngeal carcinoma tissue].

Science.gov (United States)

Li, Manyi; Liu, Jishengi; Zhou, Hui; Wu, Wenying; Xiao, Gensheng; Yu, Yafeng; Guo, Lingchuan

2014-03-01

To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma, and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy. The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mucos was detected by immunohistochemical S-P method. The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes 0.713, P < 0.05) and tumor sites (r = -0.750, P < 0.05), but it have no notable difference with pathology differentiation, age, infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer. (1) The expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. (2) It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. (3) It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. (4) Other than UICC-TNM stage, pathology differentiation, it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.

ÜRO asesekretäri kriitika USA suunal ajas viimase marru / Liise Lehtsalu

Index Scriptorium Estoniae

Lehtsalu, Liise

2006-01-01

ÜRO asesekretär Malloch Brown kritiseeris oma kõnes USA tahtmatust teavitada ameeriklasi ÜRO osast USA välispoliitikas. USA ÜRO-suursaadiku John Boltoni reageering Browni märkustele. Lisa: Rikaste ja vaeste riikide vastuolud

RoHS Compliance - Is the Global Electronics Industry Ready?

OpenAIRE

Head, Marieke; Hróarsson, Hallur

2006-01-01

RoHS is an EU directive that was proposed along with the WEEE Directive in 2002 as a part of a plan to promote extended producer responsibility within the electronics industry. Together, these two directives seek to make electrical and electronic equipment easier to manage both in terms of environmental impacts and recycling. The RoHS Directive seeks to remove lead, cadmium, mercury, hexavalent chromium and two brominated flame retardants from all consumer electrical equipment. This paper dea...

Planetary transit candidates in the CoRoT-SRc01 field

DEFF Research Database (Denmark)

Erikson, A.; Santerne, A.; Renner, S.

2012-01-01

Context. CoRoT is a pioneering space mission whose primary goals are stellar seismology and extrasolar planets search. Its surveys of large stellar fields generate numerous planetary candidates whose lightcurves have transit-like features. An extensive analytical and observational follow-up effort...... is undertaken to classify these candidates. Aims. We present the list of planetary transit candidates from the CoRoT LRa01 star field in the Monoceros constellation toward the Galactic anti-center direction. The CoRoT observations of LRa01 lasted from 24 October 2007 to 3 March 2008. Methods. We acquired...... and analyzed 7470 chromatic and 3938 monochromatic lightcurves. Instrumental noise and stellar variability were treated with several filtering tools by different teams from the CoRoT community. Different transit search algorithms were applied to the lightcurves. Results. Fifty-one stars were classified...

Transiting exoplanets from the CoRoT space mission. IV. CoRoT-Exo-4b: a transiting planet in a 9.2 day synchronous orbit

Science.gov (United States)

Aigrain, S.; Collier Cameron, A.; Ollivier, M.; Pont, F.; Jorda, L.; Almenara, J. M.; Alonso, R.; Barge, P.; Bordé, P.; Bouchy, F.; Deeg, H.; de La Reza, R.; Deleuil, M.; Dvorak, R.; Erikson, A.; Fridlund, M.; Gondoin, P.; Gillon, M.; Guillot, T.; Hatzes, A.; Lammer, H.; Lanza, A. F.; Léger, A.; Llebaria, A.; Magain, P.; Mazeh, T.; Moutou, C.; Paetzold, M.; Pinte, C.; Queloz, D.; Rauer, H.; Rouan, D.; Schneider, J.; Wuchter, G.; Zucker, S.

2008-09-01

CoRoT, the first space-based transit search, provides ultra-high-precision light curves with continuous time-sampling over periods of up to 5 months. This allows the detection of transiting planets with relatively long periods, and the simultaneous study of the host star's photometric variability. In this Letter, we report the discovery of the transiting giant planet CoRoT-Exo-4b and use the CoRoT light curve to perform a detailed analysis of the transit and determine the stellar rotation period. The CoRoT light curve was pre-processed to remove outliers and correct for orbital residuals and artefacts due to hot pixels on the detector. After removing stellar variability about each transit, the transit light curve was analysed to determine the transit parameters. A discrete autocorrelation function method was used to derive the rotation period of the star from the out-of-transit light curve. We determine the periods of the planetary orbit and star's rotation of 9.20205 ± 0.00037 and 8.87 ± 1.12 days respectively, which is consistent with this being a synchronised system. We also derive the inclination, i = 90.00_-0.085+0.000 in degrees, the ratio of the orbital distance to the stellar radius, a/Rs = 17.36-0.25+0.05, and the planet-to-star radius ratio R_p/R_s=0.1047-0.0022+0.0041. We discuss briefly the coincidence between the orbital period of the planet and the stellar rotation period and its possible implications for the system's migration and star-planet interaction history. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA, Germany, and Spain. The first CoRoT data will be available to the public in February 2009 from the CoRoT archive: http://idoc-corot.ias.u-psud.fr/ Figures 1, 4 and 5 are only available in electronic form at http://www.aanda.org

MO-AB-204-01: IHE RO Overview

International Nuclear Information System (INIS)

Hadley, S.

2016-01-01

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity

Radial velocity follow-up of CoRoT transiting exoplanets

Directory of Open Access Journals (Sweden)

Deleuil M.

2011-02-01

Full Text Available We report on the results from the radial-velocity follow-up program performed to establish the planetary nature and to characterize the transiting candidates discovered by the space mission CoRoT. We use the SOPHIE at OHP, HARPS at ESO and the HIRES at Keck spectrographs to collect spectra and high-precision radial velocity (RV measurements for several dozens different candidates from CoRoT. We have measured the Rossiter-McLaughlin effect of several confirmed planets, especially CoRoT-1b which revealed that it is another highly inclined system. Such high-precision RV data are necessary for the discovery of new transiting planets. Furthermore, several low mass planet candidates have emerged from our Keck and HARPS data.

WE-B-Exhibit Hall-01: Ask the RO-ILS Experts

Energy Technology Data Exchange (ETDEWEB)

Ezzell, G [Mayo Clinic Arizona, Phoenix, AZ (United States); Sanscrainte, E [Clarity PSO, Chicago, IL (United States); Tomlinson, C [ASTRO, Fairfax, VA (United States)

2015-06-15

Have a question about RO-ILS: Radiation Oncology Incident Learning System™, or interested in learning more? Sponsored by the American Society for Radiation Oncology (ASTRO) and AAPM, RO-ILS is the only medical specialty society-sponsored incident learning system for radiation oncology. It facilitates safer and higher quality care in radiation oncology by providing a mechanism for shared learning in a secure and non-punitive environment. Please join our RO-ILS experts for a question and answer session on Wednesday, July 15th at 8:30 in the Partners in Solutions Room in Exhibit Hall C. Our experts include: Gary Ezzell, PhD, Mayo Clinic Arizona, [Brett Miller, Phillip Beron, and Derek Brown], Emily Sanscrainte from Clarity PSO and Cindy Tomlinson, MPP, ASTRO.

ÜRO teatel peavad toidukriisi eest vastutama rikkad riigid / Liisi Poll

Index Scriptorium Estoniae

Poll, Liisi, 1980-

2008-01-01

ÜRO peasekretär Ban Ki-Moon kutsus ÜRO põllumajandus- ja toiduorganisatsiooni erakorralisel toidukriisi-teemalisel tippkohtumisel Roomas riike üles vähendama ekspordipiiranguid ja imporditariife, et toiduvarude nappust vähendada. Vt. samas: Kohtumise poliitilised häbiplekid

Thematic trip: "Save Roşia MontanÄă"

Science.gov (United States)

Eugenia, Marcu

2015-04-01

The name Roşia Montană, situated in Transylvania, became well known after a Romanian-Canadian company, Roşia Montană Gold Company (RMGC), obtained the concession license on exploitation for gold and silver minerals in the Roşia Montană area. The project consists of opening the largest surface gold mines in Europe using cyanide, which will include four open pits and a processing plant for gold and silver in The Roşia Valley and a tailings facility with an area of 367 hectares in the Corna Valley. One of the main fears is related to a possible ecological accident like the one in Baia Mare in 2000, when a tailing facility dam break led to cyanide pollution of Tisa and Danube rivers that resulted in the death of 1,200 tons of fish and contamination of water resources for 2 million people. This thematic trip is important for the scientific preparation of students and an opportunity to educate them in the spirit of environmental protection. The training and education of students will require assimilation and understanding, actively and consciously, using the knowledge acquired during the compulsory curriculum and training skills. REASON: The continuous degradation of the environment is a major crisis due to human intervention in nature, and the proposed Roşia Montană mining project will continue this trend. The company proposes to extract gold from mines by using the gold separation technique using cyanide, a process that involves destroying a total area of 16 km² which includes 5 mountains, 7 churches, 11 cemeteries and the ruins of Alburnus Maior Citadel, as well as creating pollution that would last for hundreds of years. The extraction of gold from low-grade ores using cyanide processes was estimated to result in a worldwide emission of 45,300 tons of hydrogen cyanide. Environmental education for a healthy life has children as target group, because they are the trustees and beneficiaries of tomorrow's natural resources and can influence the attitudes of

Human Ro60 (SSA2) genomic organization and sequence alterations, examined in cutaneous lupus erythematosus.

Science.gov (United States)

Millard, T P; Ashton, G H S; Kondeatis, E; Vaughan, R W; Hughes, G R V; Khamashta, M A; Hawk, J L M; McGregor, J M; McGrath, J A

2002-02-01

The Ro 60 kDa protein (Ro60 or SSA2) is the major component of the Ro ribonucleoprotein (Ro RNP) complex, to which an immune response is a specific feature of several autoimmune diseases. The genomic organization and any sequence variation within the DNA encoding Ro60 are unknown. To characterize the Ro60 gene structure and to assess whether any sequence alterations might be associated with serum anti-Ro antibody in subacute cutaneous lupus erythematosus (SCLE), thus potentially providing new insight into disease pathogenesis. The cDNA sequence for Ro60 was obtained from the NCBI database and used for a BLAST search for a clone containing the entire genomic sequence. The intron-exon borders were confirmed by designing intronic primer pairs to flank each exon, which were then used to amplify genomic DNA for automated sequencing from 36 caucasian patients with SCLE (anti-Ro positive) and 49 with discoid LE (DLE, anti-Ro negative), in addition to 36 healthy caucasian controls. Heteroduplex analysis of polymerase chain reaction (PCR) products from patients and controls spanning all Ro60 exons (1-8) revealed a common bandshift in the PCR products spanning exon 7. Sequencing of the corresponding PCR products demonstrated an A > G substitution at nucleotide position 1318-7, within the consensus acceptor splice site of exon 7 (GenBank XM001901). The allele frequencies were major allele A (0.71) and minor allele G (0.29) in 72 control chromosomes, with no significant differences found between SCLE patients, DLE patients and controls. The genomic organization of the DNA encoding the Ro60 protein is described, including a common polymorphism within the consensus acceptor splice site of exon 7. Our delineation of a strategy for the genomic amplification of Ro60 forms a basis for further examination of the pathological functions of the Ro RNP in autoimmune disease.

Transiting exoplanets from the CoRoT space mission . XIX. CoRoT-23b: a dense hot Jupiter on an eccentric orbit

DEFF Research Database (Denmark)

Rouan, D.; Parviainen, H.; Moutou, C.

2012-01-01

We report the detection of CoRoT-23b, a hot Jupiter transiting in front of its host star with a period of 3.6314 ± 0.0001 days. This planet was discovered thanks to photometric data secured with the CoRoT satellite, combined with spectroscopic radial velocity (RV) measurements. A photometric search...... to be 7 Gyr, not far from the transition to subgiant, in agreement with the rather large stellar radius. The two features of a significant eccentricity of the orbit and of a fairly high density are fairly uncommon for a hot Jupiter. The high density is, however, consistent with a model of contraction...... is more than a few 105, a value that is the lower bound of the usually expected range. Even if CoRoT-23b  features a density and an eccentricity that are atypical of a hot Jupiter, it is thus not an enigmatic object....

Experimental Study of Advanced Treatment of Coking Wastewater Using MBR-RO Combined Process

Science.gov (United States)

Zhang, Lei; Hwang, Jiannyang; Leng, Ting; Xue, Gaifeng; Chang, Hongbing

A membrane bioreactor-reverse osmosis (MBR-RO) combined process was used for advanced treatment of coking wastewater from secondary biological treatment. MBR and RO units' treatment efficiency for the pollution removal were conducted, and effects of raw water conductivity and trans-membrane pressure on water yield and desalination rate in RO unit were investigated in detail. The experimental results proved that MBR-RO combined process ran steadily with good treatment effect, which could obtain stable effluent water quality and met the requirement of "Design Criterion of the Industrial Circulating Cooling Water Treatment" (GB 50050-2007).

Sensitization by SR-2508 plus Ro 03-8799

International Nuclear Information System (INIS)

Stone, H.B.; Luu, Y.H.; Lam, K.N.

1986-01-01

The primary toxicity of Ro 03-8799 is a central nervous system toxicity, whereas that of SR-2508 is a peripheral neuropathy. The feasibility of reducing overall toxicity while maintaining maximal radiosensitization by using the two sensitizers together was tested. The LD50/2 of Ro 03-8799 was 0.68 mg/g body wt (mg/gbw) after intravenous (i.v.) administration, and that of SR-2508 was 4.4 mg/gbw after i.v. administration. When both drugs were given together in equitoxic proportions, the LD50/2 was 0.45 mg of Ro 03-8799 plus 2.9 mg of SR-2508/gbw. These doses are 66% of the respective LD50/2 values of the drugs when given separately. Radiosensitization was evaluated using in vivo-in vitro assays with EMT6/SF tumors in BALB/c mice. At drug doses between 10 and 60% of the LD50/2, sensitization was generally maximal and similar to that from misonidazole, but there was less sensitization below this dose, both with the drugs given separately and together. If chronic toxicities of these drugs overlap as do the acute toxicities there will be little or no additional benefit from using these drugs in combination, compared to using them separately

Geografická výročí

Czech Academy of Sciences Publication Activity Database

Martínek, Jiří

2017-01-01

Roč. 36, č. 2 (2017), s. 69-72 ISSN 1213-1075 Institutional support: RVO:67985963 Keywords : Czech geography * personalities * anniversaries Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

Med-Ro Hybrid desalination as option to supply fresh water in BABEL Islands Province

International Nuclear Information System (INIS)

Siti Alimah; Sudi Ariyanto; June Mellawati; Budiarto

2011-01-01

Med-Ro hybrid desalination systems are combining both thermal (Med) and membrane (Ro) desalination processes with power generation systems. This configuration has more economical and operational benefits in comparison with single desalination plant. Hybrid configurations are characterized by flexibility in operation, specific energy consumption (33.50 kWh/m 3 ) is lower than Med (36.54 kWh/m 3 ) and high plant availability. The objective of study is to analyze the Med-Ro hybrid desalination as an option to add supply fresh water in Babel Islands Province, in terms of technology and economy aspects. The result of study showed that adopting nuclear power plants as dual-purpose for power generation and producing fresh water is has economic competitiveness than fossil-fired generation plants. Med-Ro hybrid configuration, with feed Ro from heat rejection of Med system is suitable as fresh water supply add option because increase of Ro feed temperature will increase flux. Economic analysis of water cost are performed using the Deep-3.2. Water cost of hybrid Med-Ro desalination with energy of NPP (0.581 $/m ) is lower than that of Med water cost (0.752 $/m ) . Water cost of hybrid Med-Ro with energy of NPP (0.581 $/m ) is lower than that of water cost of energy with fossil-fired generation plants (0.720 $/m 3 ). (author)

VizieR Online Data Catalog: CoRoT observation log (N2-4.4) (CoRoT, 2009-2016)

Science.gov (United States)

COROT Team

2014-03-01

CoRoT is a space astronomy mission devoted to the study of the variability with time of stars brightness, with an extremely high accuracy (100 times better than from the ground), on very long durations (up to 150 days) and a very high duty cycle (more than 90%). The mission was led by CNES in association with four french laboratories, and 7 participating countries and agencies (Austria, Belgium, Brazil, Germany, Spain, and the ESA Science Programme). The satellite is composed of a PROTEUS platform (the 3rd in the serie), and a unique instrument: a stellar photometer. It has been launched on December 27th 2006 by a Soyuz Rocket, from Baikonour. The mission has lasted almost 6 years (the nominal 3 years duration and a 3 years extension) and has observed more than 160 000 stars. It stopped to send data suddenly on November 2nd 2012. CoRoT is performing Ultra High Precision Photomery of Stars to detect and characterise the variability of their luminosity with two main directions: - variability of the object itself: oscillations, rotation, magnetic activity - variability due to external causes as bodies in orbit around the star: planets and stars The original scientific objectives were focussed on the study of stellar pulsations (asteroseismology) to probe the internal structure of stars, and the detection of small exoplanets through their "transit in front of their host star, and the measurement of their size. This lead to introduce two modes of observations, working simultaneously: - The bright star mode dedicated to very precise seismology of a small sample of bright and closeby stars (data presented in file momentarily named "astero.dat", but should change in the near future to to "bright star.dat") - The faint star mode, observing a very large number of stars at the same time, to detect transits, which are rare events, as they imply the alignment of the star, the planet and the observer (data presented in momentarily named "exo.dat" but should change in the near

Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

Science.gov (United States)

Gao, Jingjing; Yao, Licheng; Xia, Tingting; Liao, Xuebin; Zhu, Deyu; Xiang, Ye

2018-04-01

The human kynurenine 3-monooxygenase (hKMO) is a potential therapeutic target for neurodegenerative and neurologic disorders. Inhibition of KMO by Ro 61-8048, a potent, selective, and the most widely used inhibitor of KMO, was shown effective in various models of neurodegenerative or neurologic disorders. However, the molecular basis of hKMO inhibition by Ro 61-8048 is not clearly understood. Here, we report biochemistry studies on hKMO and crystal structures of an hKMO homolog, pfKMO from Pseudomonas fluorescens, in complex with the substrate l-kynurenine and Ro 61-8048. We found that the C-terminal ∼110 aa are essential for the enzymatic activity of hKMO and the homologous C-terminal region of pfKMO folds into a distinct, all-α-helical domain, which associates with the N-terminal catalytic domain to form a unique tunnel in proximity to the substrate-binding pocket. The tunnel binds the Ro 61-8048 molecule, which fills most of the tunnel, and Ro 61-8048 is hydrogen bonded with several completely conserved residues, including an essential catalytic residue. Modification of Ro 61-8048 and biochemical studies of the modified Ro 61-8048 derivatives suggested that Ro 61-8048 inhibits the enzyme in an allosteric manner by affecting the conformation of the essential catalytic residue and by blocking entry of the substrate or product release. The unique binding sites distinguish Ro 61-8048 as a noncompetitive and highly selective inhibitor from other competitive inhibitors, which should facilitate further optimization of Ro 61-8048 and the development of new inhibitory drugs to hKMO.-Gao, J., Yao, L., Xia, T., Liao, X., Zhu, D., Xiang, Y. Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048.

RO-75, Reverse Osmosis Plant Design Optimization and Cost Optimization

International Nuclear Information System (INIS)

Glueckstern, P.; Reed, S.A.; Wilson, J.V.

1999-01-01

1 - Description of problem or function: RO75 is a program for the optimization of the design and economics of one- or two-stage seawater reverse osmosis plants. 2 - Method of solution: RO75 evaluates the performance of the applied membrane module (productivity and salt rejection) at assumed operating conditions. These conditions include the site parameters - seawater salinity and temperature, the membrane module operating parameters - pressure and product recovery, and the membrane module predicted long-term performance parameters - lifetime and long flux decline. RO75 calculates the number of first and second stage (if applied) membrane modules needed to obtain the required product capacity and quality and evaluates the required pumping units and the power recovery turbine (if applied). 3 - Restrictions on the complexity of the problem: The program does not optimize or design the membrane properties and the internal structure and flow characteristics of the membrane modules; it assumes operating characteristics defined by the membrane manufacturers

Simple, Accurate, Low-cost RO Science with the Iridium-NEXT Satellite Constellation

Science.gov (United States)

Meehan, T.; Mannucci, A. J.

2011-12-01

Over the last decade, a disparate collection of GNSS-RO instruments have been measuring the refractivity of the Earth's ionosphere and atmosphere. These measurements have proven to be robust and precise data sets for operational weather, climate and geospace sciences. Future GNSS-RO weather and science will most benefit from a large number of profiles (10000+/day), with lower latency and greater accuracy in the lowest 5 km altitude. For weather, latencies below 90 minutes are required, 30 minutes desired. Space weather latency requirements are more stringent, with 15 minutes being a long sought goal. Climate studies benefit from averaging measurements uniformly distributed over the Earth, acquired over decades, with local time sampling errors minimized by dense coverage or well designed orbits. There's much more of course, because space GNSS science is still nascent but with gathering momentum among the international community. Although individual GNSS-RO instruments are relatively cheap as space hardware goes, growing the measurement density can be costly when a dozen or more are required for a single program. In this presentation, we propose a novel technique for greatly reducing the cost of a constellation of GNSS-RO instruments and discuss the science trade-offs of this approach versus the more traditional GNSS-RO designs.

Danish WEEE management in the light of the WEEE and RoHS Directives: a quantitative analysis of critical issues

DEFF Research Database (Denmark)

Pizzol, Massimo; Thomsen, Marianne

Waste from Electrical and Electronic Equipment (WEEE) is the fastest growing waste fraction in Europe and is classified as hazardous as it may include substances that have adverse effects on human health or cause damage to the environment (UNEP, 2009). The European Community Directive 2002/96/EC...... on Waste Electrical and Electronic Equipment (WEEE Directive), together with the European Community Directive 2002/95/EC on the Restriction of Hazardous Substances (RoHS Directive) were established respectively to set collection, recycling and recovery targets, and to restrict the use of six hazardous......, there is a gap between the reporting of produced and collected amounts of WEEE. This is attributable to three factors: unclear reporting obligation for business to business WEEE producers, attic effect, and improper disposal of WEEE from the consumers. Secondly, despite the restrictions introduced by the Ro...

RO5: proposal of a relevant facility in nuclear fusion research

International Nuclear Information System (INIS)

Pouzo, J.

1987-01-01

The RO5 project is a proposal of an experiment in nuclear fusion research based in a plasma focus device. The main research scopes of the experiment, with respect to the scaling law foundations and the identification of the main nuclear reaction mechanisms, are discussed. A practical aim of the experiment is to reach 10 14 - 10 15 neutrons/pulse from D-D reactions in the plasma focus using a 3 MJ capacitor bank. It represents an energy efficience of around a 5% when D-T mixture is used as filling gas in the reactor (RO5 = Reactor of 5% in energy efficience). A first RO5 design obtained with a 2D snowplow model and taken into account the operation limits recently found, is presented. (author) [pt

Vabariigi President esines ÜRO Peaassambleel

Index Scriptorium Estoniae

2007-01-01

ÜRO Peaassamblee 62. istungjärgul kõneles president Toomas Hendrik Ilves kliimamuutuse, küberjulgeoleku, kriiside reguleerimise ja rahvusvaheliste organisatsioonide koostöö teemadel. Ilmunud ka: Koit 29. sept. 2007, lk. 6; Eesti Elu 28. sept. 2007, lk. 2; ingl. k. Vaba Eesti Sõna 4. okt. 2007, lk. 12, pealk.: The President of the Republic Spoke to the UN General Assembly. Vabariigi President töövisiidil Ameerika Ühendriikides 20.-26.09.2007

Zonal NePhRO scoring system: a superior renal tumor complexity classification model.

Science.gov (United States)

Hakky, Tariq S; Baumgarten, Adam S; Allen, Bryan; Lin, Hui-Yi; Ercole, Cesar E; Sexton, Wade J; Spiess, Philippe E

2014-02-01

Since the advent of the first standardized renal tumor complexity system, many subsequent scoring systems have been introduced, many of which are complicated and can make it difficult to accurately measure data end points. In light of these limitations, we introduce the new zonal NePhRO scoring system. The zonal NePhRO score is based on 4 anatomical components that are assigned a score of 1, 2, or 3, and their sum is used to classify renal tumors. The zonal NePhRO scoring system is made up of the (Ne)arness to collecting system, (Ph)ysical location of the tumor in the kidney, (R)adius of the tumor, and (O)rganization of the tumor. In this retrospective study, we evaluated patients exhibiting clinical stage T1a or T1b who underwent open partial nephrectomy performed by 2 genitourinary surgeons. Each renal unit was assigned both a zonal NePhRO score and a RENAL (radius, exophytic/endophytic properties, nearness of tumor to the collecting system or sinus in millimeters, anterior/posterior, location relative to polar lines) score, and a blinded reviewer used the same preoperative imaging study to obtain both scores. Additional data points gathered included age, clamp time, complication rate, urine leak rate, intraoperative blood loss, and pathologic tumor size. One hundred sixty-six patients underwent open partial nephrectomy. There were 37 perioperative complications quantitated using the validated Clavien-Dindo system; their occurrence was predicted by the NePhRO score on both univariate and multivariate analyses (P = .0008). Clinical stage, intraoperative blood loss, and tumor diameter were all correlated with the zonal NePhRO score on univariate analysis only. The zonal NePhRO scoring system is a simpler tool that accurately predicts the surgical complexity of a renal lesion. Copyright © 2014 Elsevier Inc. All rights reserved.

Multiple star systems observed with CoRoT and Kepler

Directory of Open Access Journals (Sweden)

Southworth John

2015-01-01

Full Text Available The CoRoT and Kepler satellites were the first space platforms designed to perform high-precision photometry for a large number of stars. Multiple systems display a wide variety of photometric variability, making them natural benefactors of these missions. I review the work arising from CoRoT and Kepler observations of multiple systems, with particular emphasis on eclipsing binaries containing giant stars, pulsators, triple eclipses and/or low-mass stars. Many more results remain untapped in the data archives of these missions, and the future holds the promise of K2, TESS and PLATO.

Application of indirect immunofluorescent test with an improved HEp-2 substrate tranfected with human Ro60/SSA autoantigens

International Nuclear Information System (INIS)

Lv Liangjing; Chen Shunle; Gu Yueying; Shen Nan; Bao Chunde; Wang Yuan; Xue Feng; Ye Peng; Yu Chongzhao

2006-01-01

To develop an improved substrate for indirect immunofluorescent test (IIF) to detect anti-Ro/SSA autoantibodies, the human 60-kDa Ro/SSA autoantigens (Ro60) cDNAs were obtained from placental cDNA library using PCR and were cloned into the mammalian expression vectorpEGFP-C1. Then the recombinant plasmids were transfected into HEp-2 cells. We con- firmed the overexpression, localization and antigenicity of fusion proteins in transfected cells by means of fluorescence microscopy, immunoblotting and IIF. HEp-2 and HEp-Ro60 was analyzed by IIF using a panel of 10 precipitinpositive anti-Ro human sera simultaneously. Stable expression of Ro60-GFP (green fluorescent protein) fusion proteins maintained ten more generations. And Ro60-GFP kept the antigenicity of Ro and had its own characteristic immunofluorescent pattern in HEp-Ro60 cells. The transfectants dramatically increased the sensitivity of IIF testing (a mean increase of 6.7-fold in endpoint titer, P<0.01). Eight (8/10) positive an- ti-Ro sera showed characteristic immunofluorescent pattern on HEp-Ro60, including two sera which were antinuclear antibodies (ANA) negative on untransfected HEp-2. IIF-ANA in all healthy sera were negative on HEp-Ro60. As a kind of new substrate of IIF, the Ro60 transfectants can be used to detect anti-Ro antibodies. In addition, transfected HEp-2 cells kept the immunofluorescent property of HEp-2 cells in IIF-ANA tests and could be employed as substrate for the routine IIF-ANA detection. The method improved the sensitivity of IIF-ANA. (authors)

RO unit for canned coffee drink processing line. Shipped to Tone Coca-Cola Bottling Co. Ltd., Ibaraki plant; Coffee line yo RO sochi. Tone Coca-Cola Bottling (kabu) Ibaraki kojo nonyu

Energy Technology Data Exchange (ETDEWEB)

Nakajima, K. [Ebara Corp., Tokyo (Japan)

1996-01-20

The paper introduces an RO unit (reverse osmotic membrane equipment) for producing water holding for the canned coffee drink processing line introduced to the Ibaraki plant of Tone Coca-Cola Bottling Co. The unit aims at reducing hardness components from city water and producing water holding for the coffee drink processing line. The capacity of the unit is 25m{sup 3}/h and the recovery rate is 80%. The unit is composed of a sand filter, an heat exchanger, a pre-filter, RO modules, a treated water tank, chemicals storage tanks, and an RO cleaning unit, which are all for pretreatment. The treated water, into which chlorine is injected, is sent through the existing activated carbon tower and micro filter to the processing line. The RO unit can remove at the same time ion and trihalomethane, pathogens, organic matters which are substances other than hardness components. The continued water bottling is possible with no need for the usual reproduction process, and the maintenance is easy. Because of the high hardness of the supplied raw water, acid is injected at the primary side of the unit for pH regulation to prevent scale deposition in the RO modules. The quality of the treated water well met the specifications. 2 figs., 2 tabs.

A comparative study of Ro 03-8799: racemic mixture and enantiomers

International Nuclear Information System (INIS)

Newman, H.F.V.; Bleehen, N.M.; Workman, P.; Dunphy, E.P.; Dische, S.; Saunders, M.I.; Des Rochers, C.; Lenox-Smith, I.; Smithen, C.E.

1986-01-01

The maximum single dose of the 2-nitroimidazole hypoxic cell radiosensitiser Ro 03-8799 is limited to 1 g/m 2 by the occurrence of a well characterised acute syndrome of sweating, nausea and mental changes. In an attempt to increase the tolerable dose, the clinical toxicity of the racemic mixture was compared with that of the R- and S-enantiomers of Ro 03-8799. Twelve patients received escalating alternate doses of racemic mixture and R- or S-enantiomer, the dose levels being 0.25 g/m 2 , 0.5 g/m 2 , 0.75 g/m 2 and 1.0 g/m 2 . Careful monitoring of the acute syndrome failed to demonstrate any consistent differences between racemic mixture and either enantiomer. This would suggest that the toxicity is not mediated via any specific central nervous system receptor. It is concluded that separation of Ro 03-8799 into its enantiomers will not enable a clinically useful increase in dosage. (author)

Exploration of the brown dwarf regime around solar-like stars by CoRoT

OpenAIRE

Csizmadia, Szilárd

2016-01-01

Aims. A summary of the CoRoT brown dwarf investigations are presented. Methods. Transiting brown dwarfs around solar like stars were studied by using the photometric time-series of CoRoT, and ground based radial velocity measurements. Results. CoRoT detected three transiting brown dwarfs around F and G dwarf stars. The occurence rate of brown dwarfs was found to be 0.20 +/- 0.15% around solar-like stars which is compatible with the value obtained by Kepler-data.

The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

KAUST Repository

Salinas-Rodriguez, Sergio G.

2015-02-18

Reliable methods for measuring and predicting the fouling potential of reverse osmosis (RO) feed water are important in preventing and diagnosing fouling at the design stage, and for monitoring pre-treatment performance during plant operation. The Modified Fouling Index Ultrafiltration (MFI-UF) constant flux is a significant development with respect to assessing the fouling potential of RO feed water. This research investigates (1) the variables influencing the MFI-UF test at constant flux filtration (membrane pore size, membrane material, flux rate); and (2) the application of MFI-UF into pre-treatment assessment and RO fouling estimation. The dependency of MFI on flux, means that to assess accurately particulate fouling in RO systems, the MFI should be measured at a flux similar to a RO system (close to 20 L/m2/h) or extrapolated from higher fluxes. The two studied membrane materials showed reproducible results; 10% for PES membranes and 6.3% for RC membranes. Deposition factors (amount of particles that remain on the surface of membrane) were measured in a full-scale plant ranging between 0.2 and 0.5. The concept of “safe MFI” is presented as a guideline for assessing pre-treatment for RO systems.

Rožňava ore field - geophysical works

Directory of Open Access Journals (Sweden)

Géczy Július

1998-12-01

Full Text Available The article prowides a review of geophysical works in the ore field Rožňava conducted up to date. Magnetometric and geoelectric methods and gravimetric measurements have been used. Geophysical works were focused to the solving regional problems whose contribution to the prospecting of vein deposits is not essential.

MO-AB-204-01: IHE RO Overview [Health Care

Energy Technology Data Exchange (ETDEWEB)

Hadley, S. [The University of Michigan (United States)

2016-06-15

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.

ÜRO - tõeliselt üleilmne foorum / Tiina Intelmann

Index Scriptorium Estoniae

Intelmann, Tiina, 1963-

2007-01-01

Eesti Vabariigi alaline esindaja ÜRO juures tutvustab maailmaorganisatsiooni põhikirjalisi eesmärke, globaliseerumise mõjusid tegevusele, raskusi rahvusvaheliste kokkulepete täitmisel, rahuvalve ja kohtupidamisega seotud küsimusi ning igapäevatööd

Apoptosis and Redistribution of the Ro Autoantigen in Balb/c Mouse Like in Subacute Cutaneous Lupus Erythematosus

Directory of Open Access Journals (Sweden)

Rafael Herrera-Esparza

2006-01-01

Full Text Available In subacute cutaneous lupus eryhematosus (SCLE the cutaneous antigens constitute the main source of Ro and La autoantigens. The aim of this investigation was to demonstrate if UV light increases the availability of Ro autoantigen in the skin, also the blocking effect of Ac-DEVD-CMK a caspase inhibitor was assessed. For this purpose newborn Balb/c mice were UVB irradiated (5–30 mJ/cm2 equivalent to a moderate to severe sunburn. Animals were injected with monoclonal anti-Ro antibodies from SCLE patients. Apoptosis was also induced by anti-Fas antibody injection. Skin samples were examined by direct immunofluoresence, by TUNEL, and the expression of caspase 3 by RT-PCR. Major findings of present studies were: 1. UVB irradiation and anti-Fas induced apoptosis of keratinocytes. 2. Apoptosis redistribute the Ro antigen on cell surface and is better triggered by Ro antibody. 3. The caspase 3 inhibitor Ac-DEVD-CMK decreases the availability of Ro autoantigen in epidermis and prevents deposition of anti-Ro. In conclusion, the caspase pathway would be blocked to avoid anti-Ro deposition along skin; this finding would be a prospect in the treatment of SCLE patients.

Transiting exoplanets from the CoRoT space mission

DEFF Research Database (Denmark)

Ollivier, M.; Gillon, M.; Santerne, A.

2012-01-01

Aims. We report the discovery of CoRoT-16b, a low density hot jupiter that orbits a faint G5V star (mV = 15.63) in 5.3523 ± 0.0002 days with slight eccentricity. A fit of the data with no a priori assumptions on the orbit leads to an eccentricity of 0.33 ± 0.1. We discuss this value and also derive......RoT-16b is a 0.535 −0.083/+0.085 MJ, 1.17 −0.14/+0.16 RJ hot Jupiter with a density of 0.44 −0.14/+0.21 g cm-3. Despite its short orbital distance (0.0618 ± 0.0015 AU) and the age of the parent star (6.73 ± 2.8 Gyr), the planet orbit exhibits significantly non-zero eccentricity. This is very uncommon...

On-line dosing of Ammonium Biflouride for reduction of silica scaling on RO membranes

Directory of Open Access Journals (Sweden)

Ehab A. Rashed

2016-08-01

The primary goal of this research is to investigate the effectiveness of using Ammonium Biflouride (ABF as an anti-scaling agent in improving the performance of the RO membranes. ABF was used as on-line dosing with different doses for mitigation of scaling caused by silica (SiO2 on RO membranes. To study the efficiency of the anti-scaling agent, Scanning Electron Microscopy & Energy Dispersive X-ray Spectroscopy (SEM–EDS were performed for all phases before and after using the anti-scaling agent on the used RO membrane surface. The main parameters measured were: silica, TDS. Flux loss was observed for the cross-flow RO membrane after filtration. ABF doses used were: 2, 4, and 6 mg/l at constant pH = 6 and the optimum dose was found to be 4 mg/l.

Large Intergenic Non-coding RNA-RoR Inhibits Aerobic Glycolysis of Glioblastoma Cells via Akt Pathway

Science.gov (United States)

Li, Yong; He, Zhi-Cheng; Liu, Qing; Zhou, Kai; Shi, Yu; Yao, Xiao-Hong; Zhang, Xia; Kung, Hsiang-Fu; Ping, Yi-Fang; Bian, Xiu-Wu

2018-01-01

Reprogramming energy metabolism is a hallmark of malignant tumors, including glioblastoma (GBM). Aerobic glycolysis is often utilized by tumor cells to maintain survival and proliferation. However, the underlying mechanisms of aerobic glycolysis in GBM remain elusive. Herein, we demonstrated that large intergenic non-coding RNA-RoR (LincRNA-RoR) functioned as a critical suppressor to inhibit the aerobic glycolysis and viability of GBM cells. We found that LincRNA-RoR was markedly reduced in GBM tissues compared with adjacent non-tumor tissues from 10 cases of GBM patients. Consistently, LincRNA-RoR expression in GBM cells was significantly lower than that in normal glial cells. The aerobic glycolysis of GBM cells, as determined by the measurement of glucose uptake and lactate production, was impaired by LincRNA-RoR overexpression. Mechanistically, LincRNA-RoR inhibited the expression of Rictor, the key component of mTORC2 (mammalian target of rapamycin complex 2), to suppress the activity of Akt pathway and impair the expression of glycolytic effectors, including Glut1, HK2, PKM2 and LDHA. Finally, enforced expression of LincRNA-RoR reduced the proliferation of GBM cells in vitro, restrained tumor growth in vivo, and repressed the expression of glycolytic molecules in GBM xenografts. Collectively, our results underscore LincRNA-RoR as a new suppressor of GBM aerobic glycolysis with therapeutic potential. PMID:29581766

ÜRO peakorterile otsitakse naabrit / Maria-Kristiina Soomre

Index Scriptorium Estoniae

Soomre, Maria-Kristiina, 1978-

2001-01-01

New Yorki, ÜRO peakorterist lõunasse hakatakse ehitama uut hoonet. Arhitektuurikonkursist on kutsutud osalema: David Childs, Richard Meier ja Peter Eisenmann; Schuman Lichtenstein Claman Efron ja HOK arhitektid; Kohn Pederson Fox, Davis Brody Bond, Toyo Ito ja Rem Koolhaas; Henry Cobb, James Ingo Freed ja Machado & Silvetti Associates; Christian de Portzamparc ja Gary Edward Handel & Associates

A New Method for Detecting and Monitoring Atmospheric Natural Hazards with GPS RO

Science.gov (United States)

Biondi, R.; Steiner, A. K.; Rieckh, T. M.; Kirchengast, G.

2014-12-01

Global Positioning System (GPS) Radio Occultation (RO) allows measurements in any meteorological condition, with global coverage, high vertical resolution, and high accuracy. With more than 13 years of data availability, RO also became a fundamental tool for studying climate change. We present here the application of RO for detecting and monitoring tropical cyclones (TCs), deep convective systems (CSs) and volcanic ash clouds (ACs).Deep CSs and TCs play a fundamental role in atmospheric circulation producing vertical transport, redistributing water vapor and trace gases, changing the thermal structure of the Upper Troposphere and Lower Stratosphere (UTLS) and affecting climate through overshooting into the stratosphere. Explosive volcanic eruptions produce large ACs dangerous for the aviation and they can impact climate when the ash is injected into the UTLS.The detection of cloud top height, the determination of cloud extent, the discrimination of ACs from CSs clouds and the detection of overshooting are main challenges for atmospheric natural hazards study. We created a reference atmosphere with a resolution of 5° in latitude and longitude, sampled on a 1° x 1° grid, and a vertical sampling of 100 m. We then compared RO profiles acquired during TCs, CSs and ACs to the reference atmosphere and computed anomaly profiles.CSs, TCs and the ACs leave a clear signature in the atmosphere which can be detected by RO. Using RO temperature and bending angle profiles we gain insight into the vertical thermal structure and developed a new method for detecting the cloud top altitude with high accuracy.We have characterized the TCs by ocean basins and intensities, showing that they have a different thermal structure and reach to different altitudes according to the basin. We provide statistics on overshooting frequency, achieving results consistent with patterns found in the literature and demonstrating that RO is well suited for this kind of study. We have analyzed the

CoRoT 101186644 : A transiting low-mass dense M-dwarf on an eccentric 20.7-day period orbit around a late F-star. Discovered in the CoRoT lightcurves

NARCIS (Netherlands)

Tal-Or, L.; Mazeh, T.; Alonso, R.; Bouchy, F.; Cabrera, J.; Deeg, H.; Deleuil, M.; Faigler, S.; Fridlund, M.; Hébrard, G.; Moutou, C.; Santerne, A.; Tingley, B.

2013-01-01

We present the study of the CoRoT transiting planet candidate 101186644, also named LRc01_E1_4780. Analysis of the CoRoT lightcurve and the HARPS spectroscopic follow-up observations of this faint (m$_V$ = 16) candidate revealed an eclipsing binary composed of a late F-type primary (T$_{eff}$ = 6090

RoHS directive: restriction of the use of lead in electronic equipment

CERN Multimedia

2007-01-01

The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here. Please note that the session will be held in French.

RoHS directive: restriction of the use of lead in electronic equipment

CERN Multimedia

2007-01-01

The European Restriction of Hazardous Substances (RoHS) directive, which entered into force on 1st July 2006, restricts the use of lead in the manufacture of electronic equipment. This has many consequences for the manufacture of printed circuit boards and assemblies, from their design and repair to the purchase of components. If you have any questions on this subject, we invite you to attend a training session which will be held at CERN from 1.30 to 5.30 to p.m. on 21st June. All the details, including the course contents and instructions on how to register for it, can be found here Please note that the session will be held in French.

CoRoT and Kepler results: Solar-like oscillators

NARCIS (Netherlands)

Hekker, S.

2013-01-01

The space-borne observatories CoRoT (Convection Rotation and planetary Transits) and Kepler have provided photometric time series data of unprecedented precision for large numbers of stars. These data have revolutionized the fields of transiting exoplanets and asteroseismology. In this review some

EXO-DAT: AN INFORMATION SYSTEM IN SUPPORT OF THE CoRoT/EXOPLANET SCIENCE

International Nuclear Information System (INIS)

Deleuil, M.; Meunier, J. C.; Moutou, C.; Surace, C.; Barbieri, M.; Agneray, F.; Granet, Y.; Guterman, P.; Deeg, H. J.; Almenara, J. M.; Debosscher, J.; Hodgkin, S.

2009-01-01

Exo-Dat is a database and an information system created primarily in support of the exoplanet program of the COnvection ROtation and planetary Transits (CoRoT) mission. In the directions of CoRoT pointings, it provides a united interface to several sets of data: stellar published catalogs, photometric and spectroscopic data obtained during the mission preparation, results from the mission and from follow-up observations, and several mission-specific technical parameters. The new photometric data constitute the subcatalog Exo-Cat, and give consistent 4-color photometry of 14.0 million stars with a completeness to 19th magnitude in the r-filter. It covers several zones in the galactic plane around CoRoT pointings, with a total area of 209 deg 2 . This Exo-Dat information system provides essential technical support to the ongoing CoRoT light-curve analyses and ground-based follow-up by supplying additional complementary information such as the prior knowledge of the star's fundamental parameters or its contamination level inside the large CoRoT photometric mask. The database is fully interfaced with VO tools and thus benefits from existing visualization and analysis tools like TOPCAT or ALADIN. It is accessible to the CoRoT community through the Web, and will be gradually opened to the public. It is the ideal tool to prepare the foreseen statistical studies of the properties of the exoplanetary systems. As a VO-compliant system, such analyses could thus benefit from the most up-to-date classifier tools.

A beta skin dose monitor using an Eberline RO-2 ion chamber

International Nuclear Information System (INIS)

Jester, W.A.; Levine, S.H.; Lin, T.J.; Hock, R.

1994-01-01

The authors have developed a portable beta skin dose monitor that uses an Eberline RO-2trademark ion chamber. The development was based, in part, upon the previous development of a beta skin dose monitor employing silicon detectors. In this current work, the two entrance windows of the RO-2 were replaced by windows having a total mass thickness of 1.74 mg/cm 2 . A two section source-detector holder was constructed. One section fastens to the RO-2 and holds the detector at the right position to determine the contact skin dose from beta emitters located on surfaces. A second section attaches to the first, and provides fixed counting geometry for radioactive samples such as hot particles. The first section also contains a slide mechanism that allows the placement of absorbers of zero (0), 8.38, and 1000 mg/cm 2 between the detector window and the beta source. The detector response to these absorbers allows for the determination of beta skin dose. The system was modeled using a Monte Carlo beta attenuation code computing the beta skin dose to RO-2 detector response as a function of absorber thickness, average beta energy, source diameter and source position. Using the RO-2 reading from each of the three absorber configurations allows the calculation of beta skin dose and the average beta energy. The results of these calculations were confirmed through the use of three massless radioactive beta sources, traceable to the National Institute of Standards and Technology, and several utility-supplied hot particles having well-established contact skin doses. An extrapolation chamber was also used to confirm the results obtained from this monitor. This system is now use at the Pennsylvania Power and Light (PP and L) Company, the project sponsor. ((orig.))

Effect of Watertight Subdivision on Subdivision Index for Medium Size Ro–Ro Passenger Ferries

Directory of Open Access Journals (Sweden)

M. Pawlowski

2017-09-01

Full Text Available Ro-pax vessels should fulfil the requirements of the current harmonised SOLAS Convention. The study analyses the effect of various ro-pax vessel subdivision arrangements on the subdivision index. A Polish ferry was chosen as a generic ship to perform the study. For illustration of damage survivability, the attained subdivision index A was calculated for a number of modified configurations. The arrangements included single and double sides above and below the car deck, with and without a double buoyant car deck. The conclusions of the study can be used in the design of new ro-pax vessels.

Limits to the presence of transiting circumbinary planets in CoRoT Data

Science.gov (United States)

Klagyivik, P.; Deeg, H. J.; Cabrera, J.; Csizmadia, Sz.; Almenara, J. M.

2017-06-01

Aims: During its flight phase, from 2007-2012, the CoRoT mission delivered light curves for over 2000 eclipsing binaries. Data from the Kepler mission have proven the existence of several transiting circumbinary planets. While light curves from CoRoT typically have lower precision and shorter coverage, the number of CoRoT targets is similar to that of Kepler and some of the known circumbinary planets could potentially be detected in CoRoT data as well. The aim of this work was to reanalyse the entire CoRoT Data set to search for the presence of circumbinary planets and to derive limits on the abundances of such planets. Methods: We developed a code that removes the signatures of eclipsing binaries from the light curves, and searches for quasi-periodic, transit-like features in the light curves after removal of binary eclipses and instrumental features. The code requires little information on sample systems and can also be used for other space missions, such as Kepler, K2, TESS, and PLATO. The code is broad in the requirements leading to detections, but was tuned to deliver an amount of detections that are manageable in a subsequent, mainly visual, assessment of their origin. Results: We identified three planet candidates in the CoRoT sample whose transits would have arisen from a single pass across the central binary; however, no candidates with transit events from multiple planetary orbits remained. We calculated the upper limits for the number of Jupiter, Saturn-, and Neptune-sized planets in co-planar orbits for different orbital period ranges. We found that there are much fewer giant planets in short periodic orbits around close binary systems than around single stars. Full Table 1 is only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/602/A117

Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species.

Science.gov (United States)

Varty, G B; Hyde, L A; Hodgson, R A; Lu, S X; McCool, M F; Kazdoba, T M; Del Vecchio, R A; Guthrie, D H; Pond, A J; Grzelak, M E; Xu, X; Korfmacher, W A; Tulshian, D; Parker, E M; Higgins, G A

2005-10-01

Previous studies have demonstrated behaviors indicative of anxiolysis in rats pretreated with the nociceptin receptor (opioid receptor like-1, ORL-1) agonist, Ro64-6198. The aim of this study was to examine the effects of Ro64-6198 in anxiety models across three species: rat, guinea pig, and mouse. In addition, the receptor specificity of Ro64-6198 was studied, using the ORL-1 receptor antagonist, J-113397, and ORL-1 receptor knockout (KO) mice. Finally, neurological studies examined potential side effects of Ro64-6198 in the rat and mouse. Ro64-6198 (3-10 mg/kg) increased punished responding in a rat conditioned lick suppression test similarly to chlordiazepoxide (6 mg/kg). This effect of Ro64-6198 was attenuated by J-113397 (10 mg/kg), but not the mu opioid antagonist, naltrexone (3 mg/kg). In addition, Ro64-6198 (1-3 mg/kg) reduced isolation-induced vocalizations in rat and guinea pig pups. Ro64-6198 (3 mg/kg) increased the proportion of punished responding in a mouse Geller-Seifter test in wild-type (WT) but not ORL-1 KO mice, whereas diazepam (1-5.6 mg/kg) was effective in both genotypes. In rats, Ro64-6198 reduced locomotor activity (LMA) and body temperature and impaired rotarod, beam walking, and fixed-ratio (FR) performance at doses of 10-30 mg/kg, i.e., three to ten times higher than an anxiolytic dose. In WT mice, Ro64-6198 (3-10 mg/kg) reduced LMA and rotarod performance, body temperature, and FR responding, but these same measures were unaffected in ORL-1 KO mice. Haloperidol (0.3-3 mg/kg) reduced these measures to a similar extent in both genotypes. These studies confirm the potent, ORL-1 receptor-mediated, anxiolytic-like effects of Ro64-6198, extending the findings across three species. Ro64-6198 has target-based side effects, although the magnitude of these effects varies across species.

Dispersion and nonlinear effects in OFDM-RoF system

Science.gov (United States)

Alhasson, Bader H.; Bloul, Albe M.; Matin, M.

2010-08-01

The radio-over-fiber (RoF) network has been a proven technology to be the best candidate for the wireless-access technology, and the orthogonal frequency division multiplexing (OFDM) technique has been established as the core technology in the physical layer of next generation wireless communication system, as a result OFDM-RoF has drawn attentions worldwide and raised many new research topics recently. At the present time, the trend of information industry is towards mobile, wireless, digital and broadband. The next generation network (NGN) has motivated researchers to study higher-speed wider-band multimedia communication to transmit (voice, data, and all sorts of media such as video) at a higher speed. The NGN would offer services that would necessitate broadband networks with bandwidth higher than 2Mbit/s per radio channel. Many new services emerged, such as Internet Protocol TV (IPTV), High Definition TV (HDTV), mobile multimedia and video stream media. Both speed and capacity have been the key objectives in transmission. In the meantime, the demand for transmission bandwidth increased at a very quick pace. The coming of 4G and 5G era will provide faster data transmission and higher bit rate and bandwidth. Taking advantages of both optical communication and wireless communication, OFDM Radio over Fiber (OFDM-RoF) system is characterized by its high speed, large capacity and high spectral efficiency. However, up to the present there are some problems to be solved, such as dispersion and nonlinearity effects. In this paper we will study the dispersion and nonlinearity effects and their elimination in OFDM-radio-over-fiber system.

Possible role of anti-SSA/Ro antibodies in the pathogenesis of pulmonary hypertension

Directory of Open Access Journals (Sweden)

Kelsey Guerreso

2016-01-01

Conclusion: It is known that pulmonary hypertension has association with autoimmune diseases, however no clear markers yet exist. Anti-SSA/Ro antibodies have been rarely described in cases of pulmonary disease, and less so in pulmonary hypertension. This case describes a unique association between isolated pulmonary hypertension and anti-SSA/Ro antibody, thereby illustrating the need to investigate this autoantibody and others in the pathogenesis of autoimmune pulmonary hypertension.

A Bacterial Biosensor for Oxidative Stress Using the Constitutively Expressed Redox-Sensitive Protein roGFP2

Directory of Open Access Journals (Sweden)

Carlos R. Arias-Barreiro

2010-06-01

Full Text Available A highly specific, high throughput-amenable bacterial biosensor for chemically induced cellular oxidation was developed using constitutively expressed redox-sensitive green fluorescent protein roGFP2 in E. coli (E. coli-roGFP2. Disulfide formation between two key cysteine residues of roGFP2 was assessed using a double-wavelength ratiometric approach. This study demonstrates that only a few minutes were required to detect oxidation using E. coli-roGFP2, in contrast to conventional bacterial oxidative stress sensors. Cellular oxidation induced by hydrogen peroxide, menadione, sodium selenite, zinc pyrithione, triphenyltin and naphthalene became detectable after 10 seconds and reached the maxima between 80 to 210 seconds, contrary to Cd2+, Cu2+, Pb2+, Zn2+ and sodium arsenite, which induced the oxidation maximum immediately. The lowest observable effect concentrations (in ppm were determined as 1.0 x 10−7 (arsenite, 1.0 x 10−4 (naphthalene, 1.0 x 10−4 (Cu2+, 3.8 x 10−4 (H2O2, 1.0 x 10−3 (Cd2+, 1.0 x 10−3 (Zn2+, 1.0 x 10−2 (menadione, 1.0 (triphenyltin, 1.56 (zinc pyrithione, 3.1 (selenite and 6.3 (Pb2+, respectively. Heavy metal-induced oxidation showed unclear response patterns, whereas concentration-dependent sigmoid curves were observed for other compounds. In vivo GSH content and in vitro roGFP2 oxidation assays together with E. coli-roGFP2 results suggest that roGFP2 is sensitive to redox potential change and thiol modification induced by environmental stressors. Based on redox-sensitive technology, E. coli-roGFP2 provides a fast comprehensive detection system for toxicants that induce cellular oxidation.

Application of monochloramine for wastewater reuse: Effect on biostability during transport and biofouling in RO membranes

KAUST Repository

Farhat, Nadia

2018-02-23

The rising demand for clean and safe water has increased the interest in advanced wastewater treatment and reuse. Reverse osmosis (RO) can provide reliable and high-quality water from treated wastewater. Biofouling inevitably occurs, certainly with wastewater effluents, resulting in RO performance decline and operational problems. Chlorination of feed water has been commonly applied to limit biological growth. However, chlorine use may lead to a loss of membrane integrity of RO systems. In this study the potential of monochloramine as an alternative for chlorine was studied by (i) evaluating the biological stability of a full-scale wastewater membrane bioreactor (MBR) effluent during transport over 13 km to a full-scale RO plant and (ii) assessing the biofouling control potential in membrane fouling simulator (MFS) and pilot-scale RO installation. Microbial water analysis was performed on samples taken at several locations in the full-scale water reuse system (MBR effluent, during transport, and at the RO inlet and outlet) using a suite of tools including heterotrophic plate counts (HPC), adenosine triphosphate (ATP), flow cytometry (FCM), and 16 S rRNA gene pyrosequencing. Growth potential tests were used to evaluate the effect of monochloramine presence and absence on bacterial growth. Results showed limited changes in the microbial water quality in the presence of monochloramine. MFS studies showed that membrane biofouling could be effectively repressed by monochloramine over prolonged time periods. The normalized salt passage in a pilot RO system with monochloramine dosage was constant over a one year period (data of last 130 days presented), demonstrating that no membrane damage occurred. From this study, it can be concluded that monochloramine dosage in wastewater applications is effective in controlling biofouling in RO systems and maintaining a monochloramine residual during water transport provides biologically stable water.

TU-CD-BRD-00: Incident Learning / RO-ILS

International Nuclear Information System (INIS)

2015-01-01

It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

TU-CD-BRD-00: Incident Learning / RO-ILS

Energy Technology Data Exchange (ETDEWEB)

NONE

2015-06-15

It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

Stuctures in hydraulic engineering : Port Infrastructure

NARCIS (Netherlands)

de Gijt, J.G.

2007-01-01

Lecture notes on the planning and design of port infrastructure, like quay walls as gravity structures, sheet-piles, jetties and ro-ro facilties; anchoring of walls. Discussion of the loads on quay walls, jetties and dolphins. Construction of quay walls. Risk analysis, fender design. Scour problems

Solar fired combined RO/MED desalination plant integrated with electrical power grid

International Nuclear Information System (INIS)

Alrobaei, H.

2006-01-01

Currently, there is a strong demand for efficient seawater desalination plants, which can meet the tougher environment regulation and energy saving requirements. From this standpoint the present work was undertaken to include proposed scheme (solar Fired Combined Reverse Osmosis (ROY Multi-Effect Distillation (MED) Seawater desalination Plant (SCDP) integrated with electrical power grid (EPG)) for repowering and modification of the conventional grid connected RO desalination plants. The model of SCDP during sunny periods may be applied to the following modes operation: *Full solar desalination (i.e. solar thermal and electrical power generation in solar plant is elivered to the desalination process and the surplus electricity is fed into EPG). *Hybrid solar desalination (I.e. a small share of the electrical power consumption for desalination process compensated by EPG). During cloudly periods and at night the SCDP operates as a conventional RO desalination plant. To establish the range, in which solar energy for seawater desalination would be competitive to fossil energy and investigates the potential effect of the proposed scheme on the repowering effectiveness, mathematical model has been developed. The repowered effectiveness, mathematical model has been developed.The repowered effectiveness in optaimizing model was characterized by the condition of attaining maximum fuel saving in the EPG. The study result shows the effectiveness of proposed scheme for modification and repowering the RO plant. For the case study. (SCDP with maual share of solar electrical power generation 67.4%) the economical effect amount 138.9 ton fuel/year for each MW design thermal energy of parabolic solar collectors array and the corresponding decrease in exhaust gases emission (Nitrogen oxides (NO x ) 0.55 ton/year.MW, carbon dioxides (CO2) 434.9 ton/year.MW). Moreover, implementation of combined RO/MED design for repowering and modification of conventional grid connected RO plant will

The driving mechanism of roAp stars

Energy Technology Data Exchange (ETDEWEB)

Dupret, M-A [Observatoire de Paris, LESIA, CNRS UMR 8109, 5 place J. Janssen, 92195 Meudon (France); Theado, S; Noels, A [Institut d' Astrophysique et Geophysique, Universite de Liege (Belgium)], E-mail: MA.dupret@obspm.fr

2008-10-15

We analyse in detail the driving mechanism of roAp stars and present the theoretical instability strip predicted by our models with solar metallicity. A particular attention is given to the interpretation of the role played by the different eigenfunctions in the stabilization of the modes at the red edge of the instability strip. The gradient of temperature in the H{sub I} opacity bump appears to play a major role in this context. We also consider the particular and complex role played by the shape of the eigenfunctions (location of the nodes, ...)

The driving mechanism of roAp stars

International Nuclear Information System (INIS)

Dupret, M-A; Theado, S; Noels, A

2008-01-01

We analyse in detail the driving mechanism of roAp stars and present the theoretical instability strip predicted by our models with solar metallicity. A particular attention is given to the interpretation of the role played by the different eigenfunctions in the stabilization of the modes at the red edge of the instability strip. The gradient of temperature in the H I opacity bump appears to play a major role in this context. We also consider the particular and complex role played by the shape of the eigenfunctions (location of the nodes, ...).

An empirical analysis of the resiliency of Ro/Ro and Ro/Pax terminal operations

OpenAIRE

Saurí Marchán, Sergi; Morales Fusco, Pau; Martín Alcalde, Enrique

2012-01-01

Regular maritime lines with roll-on roll-off vessels must offer a reliable service without substantial cost increases in order to be competitive. Port terminals need to be able to respond quickly to any disturbance that might appear and return to a smooth operational state in the minimum amount of time (resilient terminals). In this paper a complete taxonomy of the disturbances affecting the operational processes in a roll-on roll-off terminal is introduced together with a system able to...

Dinâmica evolutiva em roças de caboclos amazônicos

Directory of Open Access Journals (Sweden)

Paulo Sodero Martins

2005-04-01

Full Text Available AS ROÇAS DE CABOCLOS são unidades de agricultura de derruba e queima de populações tradicionais nas terras firmes dos trópicos brasileiros, geralmente associados com florestas. Elas são derivadas de sistemas indígenas com algumas modificações introduzidas pelos africanos e portugueses. Neste trabalho, analisamos a estrutura de comunidade dessas roças e o papel dos fatores biológicos e culturais em manter e aumentar a variabilidade genética na mais importante espécie plantada nas roças, a mandioca (Manihot esculenta. Há um alto grau de diversidade nas roças e muitas espécies que estão normalmente presentes, como mandioca, batata-doce, inhame, ariá, araruta, cupá, amendoim, apresentam o que tem sido chamado de habilidade de combinação ecológica, o que significa que elas otimizam o uso dos fatores ambientais e recursos, minimizando a sobreposição de suas arquiteturas. A variabilidade de mandioca é ampliada pelo banco de sementes em ��reas previamente ocupadas, cruzamentos interespecíficos e intervarietais, facilitada pelo arranjo das plantações escolhido pelos caboclos. Depois de criada, a variabilidade é fixada através de clonagem vegetativa, o método de reprodução comum não apenas da mandioca, mas também de outras espécies da roça, a maioria perene e apresentando "disjunção agronômica", ou seja, reprodução e produção efetivada por diferentes órgãos da planta.THE "ROÇAS DE CABOCLOS" are the slash-and-burn agricultural units of traditional populations dwelling in the lowlands of the Brazilian Tropics, generally in association with forests. They are derived from the indigenous system with some modifications introduced by the Africans and Portuguese. In this paper we analyse the community structure of the "roças" and the role of biological and cultural factors in maintaining and augmenting the genetic variability in the most important species planted in roças, the cassava (Manihot esculenta. There

Results of a customer-based, post-market surveillance survey of the HeRO access device.

Science.gov (United States)

Fusselman, Maureen

2010-08-01

In order to supplement post-market surveillance data on the HeRO vascular access device, a non-scientific customer survey was conducted to obtain quantitative data from dialysis providers caring for patients implanted with the device. Dialysis nurses involved in the care of HeRO patients were contacted in order to obtain post-implant device performance information for 10% of patients implanted with the device at the time of the survey. Thirty-eight dialysis units with a total of 65 HeRO patients participated in the survey. The total duration of HeRO device use was 348.4 months with an average use of 5.4 months. Thirty-eight of the 65 HeRO patients (58.5%) were reported to not have experienced any performance issues. There were 28 device performance incidents reported for the remaining 27 patients included in the survey. Occlusion was the single most commonly reported device-related performance issue with 18 patients (27.7%) experiencing 25 occlusive episodes. The majority of the patients who had an occlusion (66.7%) only experienced one occlusive event. Infections occurred in 4 patients (6.2%) with an overall infection rate of 0.38 per 1,000 patient days. Post-market clinical experience during the first 18 months of commercialization of the HeRO device were in line with expectations based on the results from initial clinical studies with the device. Device occlusion remains the most commonly reported performance issue with the reported rate in this survey less than that which was reported in earlier published studies with the device.

Cost analysis of the Hemodialysis Reliable Outflow (HeRO) Graft compared to the tunneled dialysis catheter.

Science.gov (United States)

Al Shakarchi, Julien; Inston, Nicholas; Jones, Robert G; Maclaine, Grant; Hollinworth, David

2016-04-01

In end-stage renal disease patients with central venous obstruction, who have limited vascular access options, the Hemodialysis Reliable Outflow (HeRO) Graft is a new alternative with a lower incidence of complications and longer effective device life compared to tunneled dialysis catheters (TDCs). We undertook an economic analysis of introducing the HeRO Graft in the UK. A 1-year cost-consequence decision analytic model was developed comparing management with the HeRO Graft to TDCs from the perspective of the National Health Service in England. The model comprises four 3-month cycles during which the vascular access option either remains functional for hemodialysis or fails, patients can experience access-related infection and device thrombosis, and they can also accrue associated costs. Clinical input data were sourced from published studies and unit cost data from National Health Service 2014-15 Reference Costs. In the base case, a 100-patient cohort managed with the HeRO Graft experienced 6 fewer failed devices, 53 fewer access-related infections, and 67 fewer device thromboses compared to patients managed with TDCs. Although the initial device and placement costs for the HeRO Graft are greater than those for TDCs, savings from the lower incidence of device complications and longer effective device patency reduces these costs. Overall net annual costs are £2600 for each HeRO Graft-managed patient compared to TDC-managed patients. If the National Health Service were to reimburse hemodialysis at a uniform rate regardless of the type of vascular access, net 1-year savings of £1200 per patient are estimated for individuals managed with the HeRO Graft. The base case results showed a marginal net positive cost associated with vascular access with the HeRO Graft compared with TDCs for the incremental clinical benefit of reductions in patency failures, device-related thrombosis, and access-related infection events in a patient population with limited options for

Magna Carta Libertatum – osmisté výročí

Czech Academy of Sciences Publication Activity Database

Blahož, Josef

2015-01-01

Roč. 154, č. 6 (2015), s. 449-464 ISSN 0231-6625 Institutional support: RVO:68378122 Keywords : Magna Carta Libertatum * development of constitutionalism * rule of law Subject RIV: AG - Legal Sciences

An information preserving method for producing full coverage CoRoT light curves

Directory of Open Access Journals (Sweden)

Pascual-Granado J.

2015-01-01

Full Text Available Invalid flux measurements, caused mainly by the South Atlantic Anomaly crossing of the CoRoT satellite, introduce aliases in the periodogram and wrong amplitudes. It has been demonstrated that replacing such invalid data with a linear interpolation is not harmless. On the other side, using power spectrum estimators for unevenly sampled time series is not only less computationally efficient but it leads to difficulties in the interpretation of the results. Therefore, even when the gaps are rather small and the duty cycle is high enough the use of gap-filling methods is a gain in frequency analysis. However, the method must preserve the information contained in the time series. In this work we give a short description of an information preserving method (MIARMA and show some results when applying it to CoRoT seismo light curves. The method is implemented as the second step of a pipeline for CoRoT data analysis.

Chronic ethanol administration increases the binding of 3H Ro-15-4513 in primary cultured spinal cord neurons

International Nuclear Information System (INIS)

Mlatre, M.; Ticku, M.K.

1989-01-01

Ro 15-4513 (ethyl-8-azido-5, 6-dihydro-5-methyl-6-oxo-4H-imidazo [1,5α], [1,4] benzodiazepine-3-carboxylate) is reported to be a selective ethanol antagonist in biochemical and behavioral studies. The effect of chronic ethanol treatment on the binding of [ 3 H]Ro 15-4513 was investigated in cultured spinal cord neurons, which are shown to possess all the elements of GABA benzodiazepine receptor complex. Chronic ethanol treatment (50 mM for 6 hr, 12 hr, 18 hr, 3 days, and 5 3 days) produced an increase in the specific binding of [ 3 H]Ro 15-4513. The increase in binding in these neurons was due to an increase in the number (B max ) of receptor sites. This effect was specific for Ro 15-4513, since identical ethanol treatment did not alter the binding of benzodiazepine antagonist [ 3 H]Ro 15-1788 or agonist [ 3 H]flunitrazepam or inverse agonist [ 3 H]methyl-β-carboline-3-carboxylate. Similar results have been reported following chronic ethanol treatment to rats. These results suggest that the Ro 15-4513 binding sites on the oligomeric GABA receptor complex are altered following chronic ethanol administration, and support the notion of a unique role of Ro 15-4513 as an ethanol antagonist

Container Traffic In European Ports

Directory of Open Access Journals (Sweden)

Elen Twrdy

2004-03-01

Full Text Available Over the last fifteen years the European transport markethas witnessed a growth of container traffic which today reachesapproximately 50 million TEU per year. From 1997 to 2002,container traffic in the northern European ports increased from14 to 20.6 million TEU per year, in the ports of the westernMedite"anean from 6 to 10 million TEU per year, and in thenorthern Adriatic ports from 0. 69 to 0. 74 million TEU per year.The ports of the northern Adriatic are located in three states(Slovenia, Croatia and Italy with different statuses in relationto the common European market. In addition, different developmentlevels of these states are reflected in different levels ofinternational commercial exchange, the development of the existinginfrastructure and plans for the construction of new infrastructures.However, all three countries share a common goaltoincrease their competitiveness in comparison with the westemEuropean ports.

Reconstruction-of-difference (RoD) imaging for cone-beam CT neuro-angiography

Science.gov (United States)

Wu, P.; Stayman, J. W.; Mow, M.; Zbijewski, W.; Sisniega, A.; Aygun, N.; Stevens, R.; Foos, D.; Wang, X.; Siewerdsen, J. H.

2018-06-01

Timely evaluation of neurovasculature via CT angiography (CTA) is critical to the detection of pathology such as ischemic stroke. Cone-beam CTA (CBCT-A) systems provide potential advantages in the timely use at the point-of-care, although challenges of a relatively slow gantry rotation speed introduce tradeoffs among image quality, data consistency and data sparsity. This work describes and evaluates a new reconstruction-of-difference (RoD) approach that is robust to such challenges. A fast digital simulation framework was developed to test the performance of the RoD over standard reference reconstruction methods such as filtered back-projection (FBP) and penalized likelihood (PL) over a broad range of imaging conditions, grouped into three scenarios to test the trade-off between data consistency, data sparsity and peak contrast. Two experiments were also conducted using a CBCT prototype and an anthropomorphic neurovascular phantom to test the simulation findings in real data. Performance was evaluated primarily in terms of normalized root mean square error (NRMSE) in comparison to truth, with reconstruction parameters chosen to optimize performance in each case to ensure fair comparison. The RoD approach reduced NRMSE in reconstructed images by up to 50%–53% compared to FBP and up to 29%–31% compared to PL for each scenario. Scan protocols well suited to the RoD approach were identified that balance tradeoffs among data consistency, sparsity and peak contrast—for example, a CBCT-A scan with 128 projections acquired in 8.5 s over a 180°  +  fan angle half-scan for a time attenuation curve with ~8.5 s time-to-peak and 600 HU peak contrast. With imaging conditions such as the simulation scenarios of fixed data sparsity (i.e. varying levels of data consistency and peak contrast), the experiments confirmed the reduction of NRMSE by 34% and 17% compared to FBP and PL, respectively. The RoD approach demonstrated superior performance in 3D angiography

Cholesterol biosynthesis inhibitor RO 48-8071 suppresses growth of hormone-dependent and castration-resistant prostate cancer cells

Directory of Open Access Journals (Sweden)

Liang Y

2016-05-01

Full Text Available Yayun Liang,1 Benford Mafuvadze,1 Johannes D Aebi,2 Salman M Hyder1 1Dalton Cardiovascular Research Center and Department of Biomedical Sciences, University of Missouri-Columbia, Columbia, MO, USA; 2Medicinal Chemistry, Roche Pharma Research and Early Development (pRED, Roche Innovation Center Basel, F Hoffmann-La Roche Ltd., Basel, Switzerland Abstract: Standard treatment for primary prostate cancer includes systemic exposure to chemotherapeutic drugs that target androgen receptor or antihormone therapy (chemical castration; however, drug-resistant cancer cells generally emerge during treatment, limiting the continued use of systemic chemotherapy. Patients are then treated with more toxic standard therapies. Therefore, there is an urgent need for novel and more effective treatments for prostate cancer. The cholesterol biosynthetic pathway is an attractive therapeutic target for treating endocrine-dependent cancers because cholesterol is an essential structural and functional component of cell membranes as well as the metabolic precursor of endogenous steroid hormones. In this study, we have examined the effects of RO 48-8071 (4'-[6-(allylmethylaminohexyloxy]-4-bromo-2'-fluorobenzophenone fumarate; Roche Pharmaceuticals internal reference: RO0488071 (RO, which is an inhibitor of 2, 3-oxidosqualene cyclase (a key enzyme in the cholesterol biosynthetic pathway, on prostate cancer cells. Exposure of both hormone-dependent and castration-resistant human prostate cancer cells to RO reduced prostate cancer cell viability and induced apoptosis in vitro. RO treatment reduced androgen receptor protein expression in hormone-dependent prostate cancer cells and increased estrogen receptor β (ERβ protein expression in both hormone-dependent and castration-resistant prostate cancer cell lines. Combining RO with an ERβ agonist increased its ability to reduce castration-resistant prostate cancer cell viability. In addition, RO effectively suppressed the

Plantio direto de alface americana sobre plantas de cobertura dessecadas ou roçadas

Directory of Open Access Journals (Sweden)

Andréia Cristina Silva Hirata

2014-06-01

Full Text Available O objetivo deste trabalho foi avaliar o plantio direto de alface americana no verão sobre plantas de cobertura dessecadas ou roçadas em cultivos sucessivos. O trabalho foi desenvolvido no município de Álvares Machado, São Paulo, Brasil. O delineamento experimental foi em blocos ao acaso, dispostos em parcelas subdivididas, com quatro repetições. O fator da parcela principal foram dois manejos das plantas de cobertura (dessecadas com herbicida ou roçadas e as subparcelas, seis espécies de plantas de cobertura (Cajanus cajan cv. IAPAR 43, Crotalaria spectabilis, Crotalaria juncea, Mucuna pruriens, Pennisetum glaucum e vegetação natural, além da testemunha sem plantas de cobertura. O manejo roçado apresentou desempenho inferior no primeiro cultivo da alface, todavia não diferiu do manejo químico no segundo cultivo. A cobertura do solo com mucuna apresentou maior produtividade da alface no primeiro cultivo devido ao excesso de palha das demais coberturas, o qual prejudicou o estabelecimento da alface. No segundo cultivo não houve diferenças entre as coberturas. A roçagem de plantas de cobertura é uma opção viável para plantio direto de alface sem herbicidas.

Hemodialysis Reliable Outflow (HeRO) device in end-stage dialysis access: a decision analysis model.

Science.gov (United States)

Dageforde, Leigh Anne; Bream, Peter R; Moore, Derek E

2012-09-01

The Hemodialysis Reliable Outflow (HeRO) dialysis access device is a permanent tunneled dialysis graft connected to a central venous catheter and is used in patients with end-stage dialysis access (ESDA) issues secondary to central venous stenosis. The safety and effectiveness of the HeRO device has previously been proven, but no study thus far has compared the cost of its use with tunneled dialysis catheters (TDCs) and thigh grafts in patients with ESDA. A decision analytic model was developed to simulate outcomes for patients with ESDA undergoing placement of a HeRO dialysis access device, TDC, or thigh graft. Outcomes of interest were infection, thrombosis, and ischemic events. Baseline values, ranges, and costs were determined from a systematic review of the literature. Total costs were based on 1 year of post-procedure outcomes. Sensitivity analyses were conducted to test model strength. The HeRO dialysis access device is the least costly dialysis access with an average 1-year cost of $6521. The 1-year cost for a TDC was $8477. A thigh graft accounted for $9567 in a 1-year time period. The HeRO dialysis access device is the least costly method of ESDA. The primary determinants of cost in this model are infection in TDCs and leg ischemia necessitating amputation in thigh grafts. Further study is necessary to incorporate patient preference and quality of life into the model. Copyright © 2012 Elsevier Inc. All rights reserved.

Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508)

International Nuclear Information System (INIS)

Maughan, T.S.; Newman, H.F.; Bleehen, N.M.; Ward, R.; Workman, P.

1990-01-01

The hypoxic cell radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole) are under evaluation as single agents (Phase III) and in combination (Phase I). Ro 03-8799 produces an acute, transient central nervous system syndrome, whereas SR 2508 causes cumulative, peripheral neurotoxicity; both effects are dose-limiting. Pharmacokinetic studies have shown the importance of area under the plasma drug concentration versus time curve (AUC) in predicting the risk of peripheral neuropathy. Most patients have very similar pharmacokinetic parameters. This study reports 2/25 patients receiving 0.75 g/m2 Ro 03-8799 plus 2.0 g/m2 SR 2508 who showed significant discrepancies in drug handling. One patient exhibited a markedly elevated AUC and prolonged t1/2 beta for SR 2508 and this was associated with an unusually rapid onset of peripheral neuropathy. A second patient showed normal handling of SR 2508 but prolonged values for both t1/2 alpha and t1/2 beta for Ro 03-8799 and unusually low levels of its N-oxide metabolite. In addition a low peak Ro 03-8799 concentration combined with a very high volume of distribution was found in this patient, leading to a normal AUC value and toxicity profile. Both patients exhibited a relatively low creatinine clearance. The mechanisms which may underlie these findings are discussed, and the importance of pharmacokinetic monitoring in the use of these agents is emphasized

The Roles of Tidal Evolution and Evaporative Mass Loss in the Origin of CoRoT-7 b

Science.gov (United States)

Jackson, Brian; Miller, Neil; Barnes, Rory; Raymond, Sean N.; Fortney, Jonathan J.; Greenberg, Richard

2010-01-01

CoRoT-7 b is the first confirmed rocky exoplanet, but, with an orbital semimajor axis of 0.0172 au, its origins may be unlike any rocky planet in our Solar System. In this study, we consider the roles of tidal evolution and evaporative mass loss in CoRoT-7 b's history, which together have modified the planet's mass and orbit. If CoRoT-7 b has always been a rocky body, evaporation may have driven off almost half its original mass, but the mass loss may depend sensitively on the extent of tidal decay of its orbit. As tides caused CoRoT-7 b's orbit to decay, they brought the planet closer to its host star, thereby enhancing the mass loss rate. Such a large mass loss also suggests the possibility that CoRoT-7 b began as a gas giant planet and had its original atmosphere completely evaporated. In this case, we find that CoRoT-7 b's original mass probably did not exceed 200 Earth masses (about two-third of a Jupiter mass). Tides raised on the host star by the planet may have significantly reduced the orbital semimajor axis, perhaps causing the planet to migrate through mean-motion resonances with the other planet in the system, CoRoT-7 c. The coupling between tidal evolution and mass loss may be important not only for CoRoT-7 b but also for other close-in exoplanets, and future studies of mass loss and orbital evolution may provide insight into the origin and fate of close-in planets, both rocky and gaseous.

Immune response against the coiled coil domain of Sjögren's syndrome associated autoantigen Ro52 induces salivary gland dysfunction.

Science.gov (United States)

Sroka, Magdalena; Bagavant, Harini; Biswas, Indranil; Ballard, Abigail; Deshmukh, Umesh S

2018-01-31

The structural domains of Ro52, termed the RING, B-box, coiled coil (CC) and B30.2/SPRY are targets of anti-Ro52 in multiple autoimmune disorders. In Sjögren's syndrome patients, the presence of anti-Ro52 is associated with higher disease severity, and in mice, they induce salivary gland hypofunction. This study was undertaken to investigate whether immune responses against different domains of Ro52, influences salivary gland disease in mice. Female NZM2758 mice were immunised with Ro52 domains expressed as recombinant fusion proteins with maltose binding protein (MBP) [MBP-RING-B-box, MBP-CC, MBP-CC(ΔC19), MBP-B30.2/SPRY]. Sera from immunised mice were studied for IgG antibodies to Ro52 by immunoprecipitation, and to salivary gland cells by immunofluorescence. Pilocarpine-induced saliva production was measured to evaluate salivary gland function. Submandibular glands were investigated by histopathology for inflammation and by immune-histochemistry for IgG deposition. Mice immunised with different Ro52-domains had comparable reactivity to Ro52 and to salivary gland cells. However, only mice immunised with the CC domain and its C-terminal truncated version CC(ΔC19) showed a significant drop in saliva production. None of the mice developed severe salivary gland inflammation. The salivary gland hypofunction significantly correlated with increased intra-lobar IgG deposits in the submandibular salivary glands. Our data demonstrate that epitope specificity of anti-Ro52 antibodies plays a critical role in the induction of glandular dysfunction. Clearly, screening Sjögren's syndrome patients for relative levels of Ro52 domain specific antibodies will be more informative for associating anti-Ro52 with clinical measures of the disorder.

E. S. R. study of free radicals formed in the irradiated DNA-Ro 7-0582 complex

Energy Technology Data Exchange (ETDEWEB)

Washino, K; Kuwabara, M; Yoshii, G [Hokkaido Univ., Sapporo (Japan)

1979-01-01

The effect of Ro 7-0582 (1-(2-hydroxy-3-methoxypropyl)-2-nitro-imidazole) on the formation of free radicals in ..gamma..-irradiated dry DNA has been investigated. Dry samples of DNA-Ro 7-0582 and DNA nucleotide-Ro 7-0582 were prepared, and e.s.r. spectra observed at 77 K immediately after gamma-irradiation. The samples were then warmed to 297 K for 30 min, and the spectra again observed at 77 K. The sensitizer brought about an increase of 30 to 40% in radical formation in DNA. The results indicated that Ro 7-0582 acts as an efficient electron scavenger on the TMP and dAMP moieties, increasing the incidence of sugar damage. Since TMP and dAMP form a complementary pair in the DNA double helix, the increase in double strand breaks induced by electron-affinic compounds seems to be responsible for the molecular mechanism of radiosensitization in living cells.

Vasodilatory effect of the stable vasoactive intestinal peptide analog RO 25-1553 in murine and rat lungs.

Directory of Open Access Journals (Sweden)

Jun Yin

Full Text Available Stable analogs of vasoactive intestinal peptide (VIP have been proposed as novel line of therapy in chronic obstructive pulmonary disease (COPD based on their bronchodilatory and anti-inflammatory effects. We speculated that VIP analogs may provide additional benefits in that they exert vasodilatory properties in the lung, and tested this hypothesis in both ex vivo and in vivo models.In isolated perfused mouse lungs and in an in vivo rat model, pulmonary blood vessels were preconstricted by hypoxia and hemodynamic changes in response to systemic (ex vivo or inhaled (in vivo administration of the cyclic VIP analog RO 25-1553 were determined.In mouse lungs, RO 25-1553 reduced intrinsic vascular resistance at normoxia, and attenuated the increase in pulmonary artery pressure in response to acute hypoxia. Consistently, inhalation of RO 25-1553 (1 mg · mL(-1 for 3 min caused an extensive and sustained (> 60 min inhibition of the pulmonary arterial pressure increase in response to hypoxia in vivo that was comparable to the effects of inhaled sildenafil. This effect was not attributable to systemic cardiovascular effects of RO 25-1553, but to a lung specific reduction in pulmonary vascular resistance, while cardiac output and systemic arterial hemodynamics remained unaffected. No adverse effects of RO 25-1553 inhalation on pulmonary gas exchange, ventilation-perfusion matching, or lung fluid content were detected.Our findings demonstrate that inhaled delivery of the stable VIP analog RO 25-1553 induces a potent and sustained vasodilatory effect in the pulmonary circulation with no detectable adverse effects. Therapeutic inhalation of RO 25-1553 may provide vascular benefits in addition to its reported anti-inflammatory and bronchodilatory effects in COPD, yet caution is warranted given the overall poor results of vasodilator therapies for pulmonary hypertension secondary to COPD in a series of recent clinical trials.

What CoRoT tells us about δ Scuti stars

Directory of Open Access Journals (Sweden)

Michel Eric

2017-01-01

Full Text Available Inspired by the so appealing example of red giants, where going from a handful of stars to thousands revealed the structure of the eigenspectrum, we inspected a large homogeneous set of around 1860 δ Scuti stars observed with CoRoT. This unique data set reveals a common regular pattern which appears to be in agreement with island modes featured by theoretical non-perturbative treatments of fast rotation. The comparison of these data with models and linear stability calculations suggests that spectra can be fruitfully characterized to first order by a few parameters which might play the role of seismic indices for δ Scuti stars, as Δv and vmax do for red giants. The existence of this pattern offers an observational support for guiding further theoretical works on fast rotation. It also provides a framework for further investigation of the observational material collected by CoRoT ([1] and Kepler ([2]. Finally, it sketches out the perspective of using δ Scuti stars pulsations for ensemble asteroseismology

Stimulation of topoisomerase II mediated DNA cleavage at specific sequence elements by the 2-nitroimidazole Ro 15-0216

International Nuclear Information System (INIS)

Sorensen, B.S.; Jensen, P.S.; Andersen, A.H.; Christiansen, K.; Alsner, J.; Thomsen, B.; Westergaard, O.

1990-01-01

The effect of the 2-nitroimidazole Ro 15-0216 upon the interaction between purified topoisomerase II and its DNA substrate was investigated. The cleavage reaction in the presence of this DNA-nonintercalative drug took place with the hallmarks of a regular topoisomerase II mediated cleavage reaction, including covalent linkage of the enzyme to the cleaved DNA. In the presence of Ro 15-0216, topoisomerase II mediated cleavage was extensively stimulated at major cleavage sites of which only one existed in the 4363 base pair pBR322 molecule. The sites stimulated by Ro 15-0216 shared a pronounced sequence homology, indicating that a specific nucleotide sequence is crucial for the action of this drug. The effect of Ro 15-0216 thus differs from that of the clinically important topoisomerase II targeted agents such as mAMSA, VM26, and VP16, which enhance enzyme-mediated cleavage at a multiple number of sites. In contrast to the previous described drugs, Ro 15-0216 did not exert any inhibitory effect on the enzyme's catalytic activity. This observation might be ascribed to the low stability of the cleavage complexes formed in the presence of Ro 15-0216 as compared to the stability of the ones formed in the presence of traditional topoisomerase II targeted drugs

Development of silica RO membranes

International Nuclear Information System (INIS)

Ikeda, Ayumi; Kawamoto, Takashi; Matsuyama, Emi; Utsumi, Keisuke; Nomura, Mikihiro; Sugimoto, Masaki; Yoshikawa, Masato

2012-01-01

Silica based membranes have been developed by using a counter diffusion CVD method. Effects of alkyl groups in the silica precursors and deposition temperatures had investigated in order to control pore sizes of the silica membranes. In this study, this type of a silica membrane was applied for RO separation. Effects of silica sources, deposition temperatures and post treatments had been investigated. Tetramethoxysilane (TMOS), Ethyltrimethoxysilane (ETMOS) and Phenyltrimethoxysilane (PhTMOS) were used as silica precursors. A counter diffusion CVD method was carried out for 90 min at 270 - 600degC on γ-alumina capillary substrates (effective length: 50 mm, φ: 4 nm: NOK Co.). O 3 or O 2 was introduced into the inside of the substrate at the O 2 rate of 0.2 L min -1 . Ion beam irradiation was carried out for a post treatment using Os at 490 MeV for 1.0 x 10 10 ions cm -2 or 3.0 x 10 10 ions cm -2 . Single gas permeance was measured by using H 2 , N 2 and SF 6 . RO tests were employed at 3.0 or 5.4 MPa for 100 mg L -1 of feed NaCl solution. First, effects of the silica sources were investigated. The total fluxes increased by increasing N 2 permeance through the silica membrane deposited by ETMOS. The maximum NaCl rejection was 28.2% at 12.2 kg m -2 h -1 of the total flux through the membrane deposited at 270degC. N 2 permeance was 9.6 x 10 -9 mol m -2 s -1 Pa -1 . While, total fluxes through the membrane deposited by using PhTMOS were smaller than those through the ETMOS membranes. The phenyl groups for the PhTMOS membrane must be important for the hydrophobic properties through the membrane. Next, effects of ion beam irradiation were tested for the TMOS membranes. Water is difficult to permeate through the TMOS membranes due to the low N 2 permeance through the membrane (3.1 x 10 -11 mol m -2 s -1 Pa -1 ). N 2 permeance increased to 7.3 x 10 -9 mol m -2 s -1 Pa -1 by the irradiation. Irradiation amounts had little effects on N 2 permeance. However, NaCl rejections

Novel antidepressant candidate RO-05 modulated glucocorticoid receptors activation and FKBP5 expression in chronic mild stress model in rats.

Science.gov (United States)

Xing, Y; Hou, J; Meng, Q; Yang, M; Kurihara, H; Tian, J

2015-04-02

In this study, a novel TRI (triple reuptake inhibitors) antidepressant candidate RO-05 (4-[1-[1-(benzoyloxy)cyclohexyl]-2-(dimethylamino)ethyl]-phenyl benzoate) was investigated in TST (tail suspension test), FST (forced swimming test) and CMS (chronic mild stress) model. Results showed RO-05 significantly decreased the immobility time in FST and TST at 4.5-, 9-, 18-mg/kg in rats and 9-, 18-, 36-mg/kg in mice. Chronic administration of 18-mg/kg RO-05 improved the behavioral index, anhedonia and normalized the hyperactivity of HPA (hypothalamic-pituitary-adrenal axis) of CMS rats. We further investigated the possible mechanisms of RO-05 in the CMS model. Eighteen milligrams per kilogram of RO-05 chronic administration significantly reversed the increase of mRNA and protein expression of FKBP5 in the CMS rat hippocampus, which facilitated the activation of GR- (glucocorticoid receptor) and GR-responsive gene Foxo1 expression. RO-05 also elevated the expression of BDNF (brain-derived neurotrophic factor) in CMS rat hippocampus. In summary, our results indicated that RO-05 is a promising antidepressant candidate. The possible antidepressant mechanisms of RO-05 were the modulation of FKBP5 expression, GR activation, corresponding inhibition of HPA axis hyperactivity, and the increase of BDNF expression. Copyright © 2015 IBRO. Published by Elsevier Ltd. All rights reserved.

Transiting exoplanets from the CoRoT space mission . XIII. CoRoT-13b: a dense hot Jupiter in transit around a star with solar metallicity and super-solar lithium content

Science.gov (United States)

Cabrera, J.; Bruntt, H.; Ollivier, M.; Díaz, R. F.; Csizmadia, Sz.; Aigrain, S.; Alonso, R.; Almenara, J.-M.; Auvergne, M.; Baglin, A.; Barge, P.; Bonomo, A. S.; Bordé, P.; Bouchy, F.; Carone, L.; Carpano, S.; Deleuil, M.; Deeg, H. J.; Dvorak, R.; Erikson, A.; Ferraz-Mello, S.; Fridlund, M.; Gandolfi, D.; Gazzano, J.-C.; Gillon, M.; Guenther, E. W.; Guillot, T.; Hatzes, A.; Havel, M.; Hébrard, G.; Jorda, L.; Léger, A.; Llebaria, A.; Lammer, H.; Lovis, C.; Mazeh, T.; Moutou, C.; Ofir, A.; von Paris, P.; Pätzold, M.; Queloz, D.; Rauer, H.; Rouan, D.; Santerne, A.; Schneider, J.; Tingley, B.; Titz-Weider, R.; Wuchterl, G.

2010-11-01

We announce the discovery of the transiting planet CoRoT-13b. Ground-based follow-up in CFHT and IAC80 confirmed CoRoT's observations. The mass of the planet was measured with the HARPS spectrograph and the properties of the host star were obtained analyzing HIRES spectra from the Keck telescope. It is a hot Jupiter-like planet with an orbital period of 4.04 days, 1.3 Jupiter masses, 0.9 Jupiter radii, and a density of 2.34 g cm-3. It orbits a G0V star with T_eff = 5 945 K, M* = 1.09 M⊙, R_* = 1.01 R⊙, solar metallicity, a lithium content of + 1.45 dex, and an estimated age of between 0.12 and 3.15 Gyr. The lithium abundance of the star is consistent with its effective temperature, activity level, and age range derived from the stellar analysis. The density of the planet is extreme for its mass, implies that heavy elements are present with a mass of between about 140 and 300 {M}⊕. The CoRoT space mission, launched on December 27th 2006, has been developed and is operated by CNES, with the contribution of Austria, Belgium, Brazil, ESA (RSSD and Science Programme), Germany and Spain. Part of the observations were obtained at the Canada-France-Hawaii Telescope (CFHT) which is operated by the National Research Council of Canada, the Institut National des Sciences de l'Univers of the Centre National de la Recherche Scientifique of France, and the University of Hawaii. Based on observations made with HARPS spectrograph on the 3.6-m European Organisation for Astronomical Research in the Southern Hemisphere telescope at La Silla Observatory, Chile (ESO program 184.C-0639). Based on observations made with the IAC80 telescope operated on the island of Tenerife by the Instituto de Astrofísica de Canarias in the Spanish Observatorio del Teide. Part of the data presented herein were obtained at the W. M. Keck Observatory, which is operated as a scientific partnership among the California Institute of Technology, the University of California and the National Aeronautics

Efficiently Combining Water Reuse and Desalination through Forward Osmosis-Reverse Osmosis (FO-RO) Hybrids: A Critical Review.

Science.gov (United States)

Blandin, Gaetan; Verliefde, Arne R D; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

2016-07-01

Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

Pengaruh Kepuasan Dan Kepercayaan Terhadap Keputusan Pembelian Ulang Pada Depot Air Minum Tris Water Reverse Osmosis System (Ro)

OpenAIRE

Fitria, Ika

2011-01-01

Kind of this survey is asociative survey which watch influence of customer satisfaction and trust to re-purchase decision on Depot Air Minum Tris Water Reverse Osmosis System (RO) and test of hypothesis use Multiple Linear Regression Analysist on α=5%. This survey used SPSS 16.00 version for windows. Research population is consumers of Depot Air Minum Tris Water Reverse Osmosis System (RO). Sample was used in this survey from customers of Depot Air Minum Tris Water Reverse Osmosis System (RO)...

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide

International Nuclear Information System (INIS)

Espinosa, Alexander; Oke, Vilija; Elfving, Ase; Nyberg, Filippa; Covacu, Ruxandra; Wahren-Herlenius, Marie

2008-01-01

Patients with the systemic autoimmune diseases Sjoegrens's syndrome and systemic lupus erythematosus often have autoantibodies against the intracellular protein Ro52. Ro52 is an E3 ligase dependent on the ubiquitin conjugation enzymes UBE2D1 and UBE2E1. While Ro52 and UBE2D1 are cytoplasmic proteins, UBE2E1 is localized to the nucleus. Here, we investigate how domains of human Ro52 regulate its intracellular localization. By expressing fluorescently labeled Ro52 and Ro52 mutants in HeLa cells, an intact coiled-coil domain was found to be necessary for the cytoplasmic localization of Ro52. The amino acids 381-470 of the B30.2 region were essential for translocation into the nucleus. Furthermore, after exposure of HeLa cells to the inflammatory mediator nitric oxide (NO), Ro52 translocated to the nucleus. A nuclear localization of Ro52 in inflamed tissue expressing inducible NO synthetase (iNOS) from cutaneous lupus patients was observed by immunohistochemistry and verified in NO-treated cultures of patient-derived primary keratinocytes. Our results show that the localization of Ro52 is regulated by endogenous sequences, and that nuclear translocation is induced by an inflammatory mediator. This suggests that Ro52 has both cytoplasmic and nuclear substrates, and that Ro52 mediates ubiquitination through UBE2D1 in the cytoplasm and through UBE2E1 in the nucleus

Development of the Bosaso Port Somalia

DEFF Research Database (Denmark)

Burcharth, Hans F.

1988-01-01

The first stage of the port of Bosaso will be completed within half a year's time. It offers accomodation for one general cargo/Ro-Ro vessel of 5,000 DWT plus 350 meters of quays for small cargo vessels and fishing boats. Hinterlands for handling of the goods are arranged along the quays. Areas...... for long term storage of goods and storage of oil are not yet provided. The first stage represents a significant development in the transport system of Somalia in being the most prosperous port in the northern Somalia because of its position at the terminal of the new north-south national main road and its...

Cocteau au cirque: The Poetics of Parade and "Le Numéro Barbette"

Directory of Open Access Journals (Sweden)

Jennifer Forrest

2003-01-01

Full Text Available Parade (1917 was a joint effort production with libretto by Jean Cocteau music by Erik Satie, decor, costumes, and curtain by Pablo Picasso, and choreography by Léonide Massine. It was not only Cocteau's first truly original work, but, as Pierre Gobin contends, Parade is central to an understanding of the structures that would inform all of his subsequent work. Equally central, proposes Lydia Crowson, is Cocteau's July 1926 Nouvelle Revue Française article on "Le Numéro Barbette." The essay on the transvestite striptease trapezist Barbette offers a poetics of the theater that will have changed little by the time of his last play, L'Impromptu du Palais Royal . The underlying system structuring the Coctelian poetics perceived by Gobin and Crowson is perhaps neither in Parade nor in "Le Numéro Barbette" alone, but in both as they propose a poetics of Coctelian art as illusion, and reference and actualize the semantic register of a particular signifying system: not the fairground parade , as contends Gobin and other critics, but the circus and circus culture. But while Parade and "Le Numéro Barbette" share a circus-related theme, the circus does not function merely as a metaphor. Each work in a different way appropriates and promotes rather the circus's revolutionary orientation toward space, its creation of "real" time, and its undermining of social signifying systems, in particular those pertaining to race and gender. The circus space is like that of dreams in that it permits the irresolution and co-existence of the sort of contradictions cited by Guillaume Apollinaire in the celebrated program notes for Parade , and produced by Barbette in his aerial number. This he learned from the circus. Parade and "Le Numéro Barbette" are indeed pivotal texts in the formulation of Cocteau's very twentieth-century poétique .

Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO Hybrids: A Critical Review

Directory of Open Access Journals (Sweden)

Gaetan Blandin

2016-07-01

Full Text Available Forward osmosis (FO is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application and water management challenges (proximity of wastewater and desalination plants, FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling.

Efficiently Combining Water Reuse and Desalination through Forward Osmosis—Reverse Osmosis (FO-RO) Hybrids: A Critical Review

Science.gov (United States)

Blandin, Gaetan; Verliefde, Arne R.D.; Comas, Joaquim; Rodriguez-Roda, Ignasi; Le-Clech, Pierre

2016-01-01

Forward osmosis (FO) is a promising membrane technology to combine seawater desalination and water reuse. More specifically, in a FO-reverse osmosis (RO) hybrid process, high quality water recovered from the wastewater stream is used to dilute seawater before RO treatment. As such, lower desalination energy needs and/or water augmentation can be obtained while delivering safe water for direct potable reuse thanks to the double dense membrane barrier protection. Typically, FO-RO hybrid can be a credible alternative to new desalination facilities or to implementation of stand-alone water reuse schemes. However, apart from the societal (public perception of water reuse for potable application) and water management challenges (proximity of wastewater and desalination plants), FO-RO hybrid has to overcome technical limitation such as low FO permeation flux to become economically attractive. Recent developments (i.e., improved FO membranes, use of pressure assisted osmosis, PAO) demonstrated significant improvement in water flux. However, flux improvement is associated with drawbacks, such as increased fouling behaviour, lower rejection of trace organic compounds (TrOCs) in PAO operation, and limitation in FO membrane mechanical resistance, which need to be better considered. To support successful implementation of FO-RO hybrid in the industry, further work is required regarding up-scaling to apprehend full-scale challenges in term of mass transfer limitation, pressure drop, fouling and cleaning strategies on a module scale. In addition, refined economics assessment is expected to integrate fouling and other maintenance costs/savings of the FO/PAO-RO hybrid systems, as well as cost savings from any treatment step avoided in the water recycling. PMID:27376337

Removing Fe, Zn and Mn from steel making plant wastewater using RO and NF membranes

Directory of Open Access Journals (Sweden)

Seyed Ahmad Mirbagheri

2016-12-01

Full Text Available Background and purpose: Excessive amount of heavy metals in industrial wastewater is a seriously crucial issue and requires efficient methods to be introduced and dealt with. Meanwhile, steel making plants as productive units in every country release large amounts of fluid into surface and underground sources. Typically, this wastewater contains heavy metals in minor amounts, while this amount could cause severe damages to the living organisms. Materials and methods: In this study, removing iron, manganese, zinc and total dissolved solid in a typical wastewater resulted from steel making plant was considered using reverse osmosis (RO and nanofiltration (NF membranes. At first, different pH values and operating pressures were applied to the wastewater. Then, these parameters were evaluated for a wastewater only containing iron to compare the interaction of other elements in iron removal. Results: The results indicated that RO and NF membranes could successfully treat industrial wastewater containing several heavy metals with high concentrations of Fe, Zn and Mn, especially at optimum pH and pressure. Moreover, the interaction of other heavy metals and components in the influent decreased the efficiency of RO but improved the NF efficiency to remove iron. To have a better image, a formula was proposed for each method to represent the influence of the parameters on removal rates. Finally, cost estimation for both procedures showed that RO was not economically-technically efficient in comparison with NF. Conclusion: NF showed an acceptable performance with high water flow which made it more suitable for industries. At the end, the relative cost analysis showed that even if the initial price of NF is high, the energy consumption and total cost of RO will be higher.

Alterations in in-vivo benzodiazepine-receptor binding of C-11-Ro15-1788 (flumazepil)

International Nuclear Information System (INIS)

Yamasaki, T.; Inoue, O.; Shinoto, H.; Ito, T.; Hashimoto, K.; Suzuki, K.; Tateno, Y.

1985-01-01

Alterations of the central benzodiazepine - receptor function caused by the change of physiological or psychological conditions, were recognized in both animal and human studies. Before the human study, animal experiments using tritiated Ro15-1788 were carried out. The stress was produced by forcing the mice to swim in a water-basin at 16 0 C for 5 min. Within 3 min after the forced swimming, the tracer was injected. Brain radioactivities in stress-loaded mice increased over a period of 15 min after the intra-venous injection of tracers, while brain activities of carrier-added tracer decreased. In human study, approximately 5 mCi of C-11-Ro15-1788, which specific activity is 0.3-1.0 Ci/μmol, were intravenously injected to each case. Measurements of the brain activity were performed using positron-CT, with blood sample collection. 31 human studies were performed on. Cerebral cortex time activity curves in several volunteers in nervous and stressful state, showed the same pattern to that in the stress-loaded animal experiment. It is important that the significant different time course of cerebral activity after the injection of labelled Ro15-1788, was observed in stressful state, compared with control, in both human and animal study. From these results, it will be concluded the positron CT study using /sup 11/C-Ro15-1788 will become a new technic to detect the change of psychological conditions in human brain and to diagnose some kind of neuropsychiatric disease

Solvents in membrane synthesis and their effect on NF/RO performance: from conventional organic solvents to ionic liquids:Solventen in membraansynthese en hun effect op NF/RO performantie: van conventionele organische solventen naar ionische vloeistoffen

OpenAIRE

Mariën, Hanne

2017-01-01

Membrane technology has grown significantly over the last decades and is used in a broad range of applications nowadays. Nanofiltration (NF) and reverse osmosis (RO) are applied for the separation of low molecular weight components (< 1000 Da) and salts from the feed stream. The main part of the commercial NF and RO membranes are either integrally skinned asymmetric (ISA) or interfacially polymerized thin film composite (TFC) membranes. Polyamide (PA) TFC membranes are the standard in aqueous...

A MCDM Analysis of the Roşia Montană Gold Mining Project

Directory of Open Access Journals (Sweden)

Adriana Mihai

2015-06-01

Full Text Available The need and estimated utility for a structured analysis of the Roşia Montană gold exploitation project have been palpable in the Romanian public sphere during the last 15 years and there is a vast amount of conflicting information and opinions on the benefits and risks involved. This article provides a comprehensive decision analysis of the Roşia Montană project. Over 100 documents from the past years have been gathered regarding the Roşia Montană mining project, which cover the main official, formal and less formal documents covering the case and produced by a wide range of stakeholders. These were then analyzed while designing a multi-criteria tree including the relevant perspectives under which the most commonly discussed four alternatives were analyzed. The result of this can be translated into a valuable recommendation for the mining company and for the political decision-makers. If these stakeholders want the continuation of the project and its acceptance by civil society, the key challenge is to increase the transparency of the process and improve the credibility and legal aspects; if these aspects cannot be met, the decision-makers need to pay attention to the alternatives available for a sustainable development in the area.

60 kD Ro and nRNP A frequently initiate human lupus autoimmunity.

Directory of Open Access Journals (Sweden)

Latisha D Heinlen

2010-03-01

Full Text Available Systemic lupus erythematosus (SLE is a clinically heterogeneous, humoral autoimmune disorder. The unifying feature among SLE patients is the production of large quantities of autoantibodies. Serum samples from 129 patients collected before the onset of SLE and while in the United States military were evaluated for early pre-clinical serologic events. The first available positive serum sample frequently already contained multiple autoantibody specificities (65%. However, in 34 SLE patients the earliest pre-clinical serum sample positive for any detectable common autoantibody bound only a single autoantigen, most commonly 60 kD Ro (29%, nRNP A (24%, anti-phospholipids (18% or rheumatoid factor (15%. We identified several recurrent patterns of autoantibody onset using these pre-diagnostic samples. In the serum samples available, anti-nRNP A appeared before or simultaneously with anti-nRNP 70 K in 96% of the patients who had both autoantibodies at diagnosis. Anti-60 kD Ro antibodies appeared before or simultaneously with anti-La (98% or anti-52 kD Ro (95%. The autoantibody response in SLE patients begins simply, often binding a single specific autoantigen years before disease onset, followed by epitope spreading to additional autoantigenic specificities that are accrued in recurring patterns.

MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

Energy Technology Data Exchange (ETDEWEB)

NONE

2016-06-15

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity.

MO-AB-204-00: Interoperability in Radiation Oncology: IHE-RO Committee Update

International Nuclear Information System (INIS)

2016-01-01

You’ve experienced the frustration: vendor A’s device claims to work with vendor B’s device, but the practice doesn’t match the promise. Getting devices working together is the hidden art that Radiology and Radiation Oncology staff have to master. To assist with that difficult process, the Integrating the Healthcare Enterprise (IHE) effort was established in 1998, with the coordination of the Radiological Society of North America. Integrating the Healthcare Enterprise (IHE) is a consortium of healthcare professionals and industry partners focused on improving the way computer systems interconnect and exchange information. This is done by coordinating the use of published standards like DICOM and HL7. Several clinical and operational IHE domains exist in the healthcare arena, including Radiology and Radiation Oncology. The ASTRO-sponsored IHE Radiation Oncology (IHE-RO) domain focuses on radiation oncology specific information exchange. This session will explore the IHE Radiology and IHE RO process for; IHE solicitation process for new profiles. Improving the way computer systems interconnect and exchange information in the healthcare enterprise Supporting interconnectivity descriptions and proof of adherence by vendors Testing and assuring the vendor solutions to connectivity problems. Including IHE profiles in RFPs for future software and hardware purchases. Learning Objectives: Understand IHE role in improving interoperability in health care. Understand process of profile development and implantation. Understand how vendors prove adherence to IHE RO profiles. S. Hadley, ASTRO Supported Activity

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

LENUS (Irish Health Repository)

Higgs, Rowan

2010-01-01

Ro52 is a member of the TRIM family of single-protein E3 ligases and is also a target for autoantibody production in systemic lupus erythematosus and Sjögren\\'s syndrome. We previously demonstrated a novel function of Ro52 in the ubiquitination and proteasomal degradation of IRF3 following TLR3\\/4 stimulation. We now present evidence that Ro52 has a similar role in regulating the stability and activity of IRF7. Endogenous immunoprecipitation of Ro52-bound proteins revealed that IRF7 associates with Ro52, an effect which increases following TLR7 and TLR9 stimulation, suggesting that Ro52 interacts with IRF7 post-pathogen recognition. Furthermore, we show that Ro52 ubiquitinates IRF7 in a dose-dependent manner, resulting in a decrease in total IRF7 expression and a subsequent decrease in IFN-alpha production. IRF7 stability was increased in bone marrow-derived macrophages from Ro52-deficient mice stimulated with imiquimod or CpG-B, consistent with a role for Ro52 in the negative regulation of IRF7 signalling. Taken together, these results suggest that Ro52-mediated ubiquitination promotes the degradation of IRF7 following TLR7 and TLR9 stimulation. As Ro52 is known to be IFN-inducible, this system constitutes a negative-feedback loop that acts to protect the host from the prolonged activation of the immune response.

A floating desalination/co-generation system using the KLT-40 reactor and Canadian RO desalination technology

International Nuclear Information System (INIS)

Humphries, J.R.; Davies, K.

2000-01-01

As the global consumption of water increases with growing populations and rising levels of industrialization, major new sources of potable water production must be developed. To address this issue efficiently and economically, a new approach has been developed in Canada for the integration of reverse osmosis (RO) desalination systems with nuclear reactors as an energy source. The resulting nuclear desalination/cogeneration plant makes use of waste heat from the electrical generation process to preheat the RO feedwater, advanced feedwater pre-treatment and sophisticated system design integration and optimization techniques. These innovations have led to improved water production efficiency, lower water production costs and reduced environmental impact. The Russian Federation is developing the KLT-40 reactor for application as a Floating Power Unit (FPU). The reactor is ideally suited for such purposes, having bad many years of successful operation as a marine propulsion reactor aboard floating nuclear powered icebreakers and other nuclear propelled vessels. Under the terms of a cooperation agreement with the Russian Federation Ministry of Atomic Energy, CANDESAL Enterprises Ltd has evaluated the FPU, containing two KLT-40 reactors, as a source of electrical energy and waste heat for RO desalination. A design concept for a floating nuclear desalination complex consisting of the FPU and a barge mounted RO desalination unit has been analyzed to establish preliminary performance characteristics for the complex. The FPU, operating as a barge mounted electrical generating station, provides electricity to the desalination barge. In addition, the condenser cooling water from the FPU is used as a source of preheated feedwater for the RO system on the desalination barge. The waste heat produced by the electrical generating process is sufficient to provide RO feedwater at a temperature of about 10 deg. C above ambient seawater temperature. Preliminary design studies have

Numerical simulation of turbulent flows past the RoBin helicopter with a four-bladed rotor

Energy Technology Data Exchange (ETDEWEB)

Xu, H.; Mamou, M.; Khalid, M. [National Research Council, Inst. for Aerospace Research, Ottawa, Ontario (Canada)]. E-mail: Hongyi.Xu@nrc.ca

2003-07-01

The current paper presents a turbulent flow simulation study past a generic helicopter RoBin with a four-bladed rotor using the Chimera moving grid approach. The aerodynamic performance of the rotor blades and their interactions with the RoBin fuselage are investigated using the k - {omega} SST turbulence model contained in the WIND code. The rotor is configured as a Chimera moving grid in a quasisteady flow field. The rotor blades are rectangular, untapered, linearly twisted and are made from NACA 0012 airfoil profile. The blade motion (rotation and cyclic pitching) schedule is specified in the NASA wind tunnel testing of a generic helicopter RoBin. The aerodynamic radial load distributions in the rotor plane are generated by integrating the pressure on each blade surfaces along the blade chordwise direction. The rotor flow interacts strongly with the flow coming off from the fuselage and thus has a significant impact on helicopter aerodynamic performance. (author)

Study on treating of low-level radioactive reactor wastewater by combined membrane process (UF-RO)

International Nuclear Information System (INIS)

Lu Yunyun; Cao Qiru; Chen Yunming; Huang Lijuan; Bai Xiaofeng; Li Bing; Feng Liang

2013-01-01

According to the characteristics of radionuclide exists in the low-level radioactive reactor waste water from HFETR, we use a new combined membrane process separation technology to study the efficient treating of low-lever radioactive reactor wastewater. First, the prepared the simulated wastewater contained Cs + , Sr 2+ , CO 2+ , Ni 2+ , and Fe 3+ . Then, we sequentially investigated the pressure, ion concentration, pH value and EDTA, which have effects on the desalination rate of membrane processing metal ions in wastewater. The results show that: in the condition of pH = 7, and added 0.15 mol/L EDTA, the simulated wastewater separated by UF-RO, desalination rates of Cs + , Sr 2+ , CO 2+ , Ni 2+ and Fe 3+ are all above 95%; In the subsequent trials, adding 0.15 mol/L EDTA into the radioactive residuary solution, and then treating by UF-RO-RO, the decontamination efficiency can reach 95.7%. (authors)

A new approach for determination of fouling potential by colloidal nanoparticles during reverse osmosis (RO) membrane filtration of seawater

International Nuclear Information System (INIS)

Park, Ji Yeon; Lim, Sungil; Park, Kihong

2013-01-01

A direct measurement of number concentration of colloidal nanoparticles (15–450 nm) in water was made with the membrane filtration-differential mobility analyzer technique, and its corresponding flux decline rate (FDR) was determined by laboratory-scale RO fouling test unit using varying number concentrations of silica nanoparticles in artificial seawaters. This relationship was used to predict fouling potential of colloidal nanoparticles in reverse osmosis (RO) membrane process of seawaters in RO plant. It was found that the FDR linearly increased with the increasing number of colloidal nanoparticles for the given concentration range and that the relationship between the number concentration and the FDR also depended on RO membrane surface properties. Data for estimated FDR values for natural seawaters after pretreatment showed a clear difference among samples, which is contrary to the pre-existing index such as silt density index and modified fouling index. Our data suggest that measurement of colloidal nanoparticles is useful for selection of proper pretreatment and successful operation of RO membrane process along with other particle fouling predictors accounting for large particles (>450 nm).

A new approach for determination of fouling potential by colloidal nanoparticles during reverse osmosis (RO) membrane filtration of seawater

Energy Technology Data Exchange (ETDEWEB)

Park, Ji Yeon; Lim, Sungil; Park, Kihong, E-mail: kpark@gist.ac.kr [Gwangju Institute of Science and Technology (GIST), School of Environmental Science and Engineering (Korea, Republic of)

2013-04-15

A direct measurement of number concentration of colloidal nanoparticles (15-450 nm) in water was made with the membrane filtration-differential mobility analyzer technique, and its corresponding flux decline rate (FDR) was determined by laboratory-scale RO fouling test unit using varying number concentrations of silica nanoparticles in artificial seawaters. This relationship was used to predict fouling potential of colloidal nanoparticles in reverse osmosis (RO) membrane process of seawaters in RO plant. It was found that the FDR linearly increased with the increasing number of colloidal nanoparticles for the given concentration range and that the relationship between the number concentration and the FDR also depended on RO membrane surface properties. Data for estimated FDR values for natural seawaters after pretreatment showed a clear difference among samples, which is contrary to the pre-existing index such as silt density index and modified fouling index. Our data suggest that measurement of colloidal nanoparticles is useful for selection of proper pretreatment and successful operation of RO membrane process along with other particle fouling predictors accounting for large particles (>450 nm).

Electrophysiological effects of Ro 22-9194, a new antiarrhythmic agent, on guinea-pig ventricular cells.

OpenAIRE

Maruyama, K; Kodama, I; Anno, T; Suzuki, R; Toyama, J

1995-01-01

1. Cardiac effects of Ro 22-9194 were examined in papillary muscles and single ventricular myocytes isolated from guinea-pigs and compared with those of moricizine. 2. In papillary muscles, both Ro 22-9194 (> or = 10 microM) and moricizine (> or = 1 microM) caused a significant dose-dependent decrease in the maximum upstroke velocity (Vmax) and a shortening of the action potential duration. 3. In the presence of either drug, trains of stimuli at rates > or = 0.2 Hz led to an exponential decli...

RoMPS concept review automatic control of space robot, volume 2

Science.gov (United States)

Dobbs, M. E.

1991-01-01

Topics related to robot operated materials processing in space (RoMPS) are presented in view graph form and include: (1) system concept; (2) Hitchhiker Interface Requirements; (3) robot axis control concepts; (4) Autonomous Experiment Management System; (5) Zymate Robot Controller; (6) Southwest SC-4 Computer; (7) oven control housekeeping data; and (8) power distribution.

Characterization and biotoxicity assessment of dissolved organic matter in RO concentrate from a municipal wastewater reclamation reverse osmosis system.

Science.gov (United States)

Sun, Ying-Xue; Gao, Yue; Hu, Hong-Ying; Tang, Fang; Yang, Zhe

2014-12-01

Reverse osmosis (RO) concentrate from municipal wastewater reclamation reverse osmosis (mWRRO) system containing organic compounds may associate with toxic risk, and its discharge might pose an environmental risk. To identify a basis for the selection of feasible technology in treating RO concentrates, the characteristics and biotoxicity of different fractions of dissolved organic matter (DOM) in RO concentrates from an mWRRO system were investigated. The results indicated that the hydrophilic neutrals (HIN), hydrophobic acids (HOA) and hydrophobic bases (HOB) accounted for 96% of the dissolved organic carbon (DOC) of the total DOM in the RO concentrate. According to the SEC chromatograph detected at 254 nm wavelength of UV, the DOM with molecular weight (MW) 1-3 kDa accounted for the majority of the basic and neutral fractions. The fluorescence spectra of the excitation emission matrix (EEM) indicated that most aromatic proteins, humic/fulvic acid-like and soluble microbial by-product-like substances existed in the fractions HOA and hydrophobic neutrals (HON). The genotoxicity and anti-estrogenic activity of the RO concentrate were 1795.6 ± 57.2 μg 4-NQOL(-1) and 2.19 ± 0.05 mg TAM L(-1), respectively. The HIN, HOA, and HOB contributed to the genotoxicity of the RO concentrate, and the HIN was with the highest genotoxic level of 1007.9 ± 94.8 μg 4-NQOL(-1). The HOA, HON, and HIN lead to the total anti-estrogenic activity of the RO concentrate, and HOA occupied approximately 60% of the total, which was 1.3 ± 0.17 mg TAM L(-1). Copyright © 2014 Elsevier Ltd. All rights reserved.

Computational molecular spectroscopy of X ˜ 2 Π NCS: Electronic properties and ro-vibrationally averaged structure

Science.gov (United States)

Hirano, Tsuneo; Nagashima, Umpei; Jensen, Per

2018-04-01

For NCS in the X ˜ 2 Π electronic ground state, three-dimensional potential energy surfaces (3D PESs) have been calculated ab initio at the core-valence, full-valence MR-SDCI+Q/[aug-cc-pCVQZ (N, C, S)] level of theory. The ab initio 3D PESs are employed in second-order-perturbation-theory and DVR3D calculations to obtain various molecular constants and ro-vibrationally averaged structures. The 3D PESs show that the X ˜ 2 Π NCS has its potential minimum at a linear configuration, and hence it is a "linear molecule." The equilibrium structure has re (N-C) = 1.1778 Å, re (C-S) = 1.6335 Å, and ∠e (N-C-S) = 180°. The ro-vibrationally averaged structure, determined as expectation values over DVR3D wavefunctions, has 〈 r (N-C)〉0 = 1.1836 Å, 〈 r (C-S)〉0 = 1.6356 Å, and 〈 ∠ (N-C-S)〉0 = 172.5°. Using these expectation values as the initial guess, a bent r0 structure having an 〈 ∠ (N-C-S)〉0 of 172.2° is deduced from the experimentally reported B0 values for NC32S and NC34S. Our previous prediction that a linear molecule, in any ro-vibrational state including the ro-vibrational ground state, is to be "observed" as being bent on ro-vibrational average, has been confirmed here theoretically through the expectation value for the bond-angle deviation from linearity, 〈 ρ bar 〉 , and experimentally through the interpretation of the experimentally derived rotational-constant values.

THE CoRoT DISCOVERY OF A UNIQUE TRIPLE-MODE CEPHEID IN THE GALAXY

Energy Technology Data Exchange (ETDEWEB)

Poretti, E. [INAF-Osservatorio Astronomico di Brera, Via E. Bianchi 46, I-23807 Merate (Italy); Baglin, A. [LESIA, Université Pierre et Marie Curie, Université Denis Diderot, Observatoire de Paris, F-92195 Meudon Cedex (France); Weiss, W. W., E-mail: ennio.poretti@brera.inaf.it [Institute of Astronomy, University of Vienna, Türkenschanzstrasse 17, A-1180 Vienna (Austria)

2014-11-10

The exploitation of the CoRoT treasure of stars observed in the exoplanetary field allowed the detection of a unusual triple-mode Cepheid in the Milky Way, CoRoT 0223989566. The two modes with the largest amplitudes and a period ratio of 0.80 are identified with the first (P {sub 1} = 1.29 days) and second (P {sub 2} = 1.03 days) radial overtones. The third period, which has the smallest amplitude but is able to produce combination terms with the other two, is the longest one (P {sub 3} = 1.89 days). The ratio of 0.68 between the first-overtone period and the third period is the unusual feature. Its identification with the fundamental radial or a nonradial mode is discussed with respect to similar cases in the Magellanic Clouds. In both cases, the period triplet and the respective ratios make the star unique in our Galaxy. The distance derived from the period-luminosity relation and the galactic coordinates put CoRoT 0223989566 in the metal-rich environment of the ''outer arm'' of the Milky Way.

Implementation of a GPS-RO data processing system for the KIAPS-LETKF data assimilation system

Science.gov (United States)

Kwon, H.; Kang, J.-S.; Jo, Y.; Kang, J. H.

2015-03-01

The Korea Institute of Atmospheric Prediction Systems (KIAPS) has been developing a new global numerical weather prediction model and an advanced data assimilation system. As part of the KIAPS package for observation processing (KPOP) system for data assimilation, preprocessing, and quality control modules for bending-angle measurements of global positioning system radio occultation (GPS-RO) data have been implemented and examined. The GPS-RO data processing system is composed of several steps for checking observation locations, missing values, physical values for Earth radius of curvature, and geoid undulation. An observation-minus-background check is implemented by use of a one-dimensional observational bending-angle operator, and tangent point drift is also considered in the quality control process. We have tested GPS-RO observations utilized by the Korean Meteorological Administration (KMA) within KPOP, based on both the KMA global model and the National Center for Atmospheric Research Community Atmosphere Model with Spectral Element dynamical core (CAM-SE) as a model background. Background fields from the CAM-SE model are incorporated for the preparation of assimilation experiments with the KIAPS local ensemble transform Kalman filter (LETKF) data assimilation system, which has been successfully implemented to a cubed-sphere model with unstructured quadrilateral meshes. As a result of data processing, the bending-angle departure statistics between observation and background show significant improvement. Also, the first experiment in assimilating GPS-RO bending angle from KPOP within KIAPS-LETKF shows encouraging results.

In-Building Wireless Distribution in legacy Multimode Fiber with an improved RoMMF system

DEFF Research Database (Denmark)

Visani, Davide; Petersen, Martin Nordal; Sorci, Francesca

2012-01-01

A radio over multimode fiber (RoMMF) system for in-building wireless distribution employing a directly modulated Fabry-Perot (FP) transmitter and the central launch technique is presented. The worst-case spurious free dynamic range (SFDR) exceeds 105 dB×Hz2/3 up to 525 m of OM2 multimode fiber (MMF......). Experimental and theoretical results are reported showing that this scheme outperforms a RoMMF system employing a distributed feed-back (DFB) laser diode (LD) and/or a mode scrambler to achieve overfilled launch (OFL). Long Term Evolution (LTE) signal transmission is achieved with high quality in terms...... of Adjacent Channel Leakage Ratio (ACLR) and Error Vector Magnitude (EVM)....

Photonic microwave carrier recovery using period-one nonlinear dynamics of semiconductor lasers for OFDM-RoF coherent detection.

Science.gov (United States)

Hung, Yu-Han; Yan, Jhih-Heng; Feng, Kai-Ming; Hwang, Sheng-Kwang

2017-06-15

This study investigates an all-optical scheme based on period-one (P1) nonlinear dynamics of semiconductor lasers, which regenerates the microwave carrier of an orthogonal frequency division multiplexing radio-over-fiber (OFDM-RoF) signal and uses it as a microwave local oscillator for coherent detection. Through the injection locking established between the OFDM-RoF signal and the P1 dynamics, frequency synchronization with highly preserved phase quality is inherently achieved between the recovered microwave carrier and the microwave carrier of the OFDM-RoF signal. A bit-error ratio down to 1.9×10-9 is achieved accordingly using the proposed scheme for coherent detection of a 32-GHz OFDM-RoF signal carrying 4  Gb/s 16-quadrature amplitude modulation data. No electronic microwave generators or electronic phase-locked loops are thus required. The proposed system can be operated up to at least 100 GHz and can be self-adapted to certain changes in the operating microwave frequency.

Optimization of AMI-MDM-RoFSO under atmospheric turbulence

Directory of Open Access Journals (Sweden)

Chaudhary Sushank

2017-01-01

Full Text Available Radio over Free Space (Ro-FSO is promising candidate for providing ubiquitous digital services especially in rural areas. This work investigates the performance of MDM of two 5Gbps-10GHz data channels over FSO link using LP 01 and LP 02 modes under the effect of atmospheric turbulences. The signal to noise ratio (SNR, total received power, modal decomposition at receiver at the receiver is also reported. The reported result shows the successful transmission of two channels with acceptable SNR over FSO link under atmospheric turbulences.

Piinatud birmalased ootavad ÜRO seni jõuetut abikätt / Karin Dean

Index Scriptorium Estoniae

Dean, Karin

2007-01-01

Buda munkade eestvedmisel toimunud massimeeleavalduste mahasurumisest Birmas. ÜRO erisaadiku Ibrahim Gambari kohtumisest nii Birma kindralite kui ka opositsiooniliidri Aung San Suu Kyiga oodatakse tulemusi ja sanktsioone Lisa: Sõjaväe haardes riik

Evaluation of TEG(®) and RoTEM(®) inter-changeability in trauma patients.

Science.gov (United States)

Hagemo, Jostein S; Næss, Paal A; Johansson, Pär; Windeløv, Nis A; Cohen, Mitchell Jay; Røislien, Jo; Brohi, Karim; Heier, Hans Erik; Hestnes, Morten; Gaarder, Christine

2013-05-01

Massive haemorrhage is a leading cause of preventable deaths in trauma. Traumatic coagulopathy is frequently present early after trauma, and is associated with increased mortality. A number of recent trials suggest that viscoelastic haemostatic assays (VHA), such as thromboelastography and thromboelastometry, are useful tools in guiding transfusion. Treatment algorithms exist for the use of VHAs but are not validated in traumatic haemorrhage. In this study we examined the inter-changeability of two commonly used VHAs, TEG(®) and RoTEM(®). A total of 184 trauma patients over the age of 18, requiring full trauma team activation, were included at three different hospitals in three different countries (Copenhagen, Denmark, San Francisco, CA, USA and Oslo, Norway). Blood samples were drawn immediately upon arrival, and TEG(®) and RoTEM(®) analyzed simultaneously. Correlations were calculated using. Spearman's rank correlation coefficient. Agreement was evaluated by Bland-Altman plots and calculation of limits of agreement. The mean ISS in the total population was 17, and the mortality was 16.5%. Mean base excess was -2.8 (SD: 4.2). The correlation coefficient for corresponding values for the two devices was 0.24 for the R-time vs CT in all centres combined. For the K-time vs CFT the correlation was 0.48, for the α-angleTEG vs α-angleRoTEM 0.44, and for MA vs MCF 0.76. Limits of agreement exceeded the preset clinically acceptable deviation of 10% for all variables in all centres except for MA/MCF in one centre (Copenhagen). Generally, correlation coefficients were lower and agreement poorer in the one centre (Oslo) where measurements were performed bedside by clinicians. Inter-changeability between TEG(®) and RoTEM(®) is limited in the trauma setting. Agreement seems poorer when clinicians operate the devices. Development and validation of separate treatment algorithms for the two devices is required. Copyright © 2012 Elsevier Ltd. All rights reserved.

A Comprehensive Study on the Application of Reverse Osmosis (RO Technology for the Petroleum Industry Wastewater Treatment

Directory of Open Access Journals (Sweden)

Shahryar Jafarinejad

2017-10-01

Full Text Available Large quantities of oily wastewaters can be generated from the activities and processes in the petroleum industry which draining of these effluents not only pollutes the environment but also reduces the yield of oil and water. Therefore, development of treatment processes for petroleum industry wastewaters is vital in order to prevent serious environmental damage and provide a source of water for beneficial use. Reverse osmosis (RO can be the most common membrane process used for desalination from oily wastewater and can produce water suitable for reuse at the petroleum industry. In this study, the application of RO technology for the petroleum industry wastewater treatment in different laboratory, pilot, field, and industrial scales have been reviewed. In addition, membrane fouling control, performance efficiency, treatment system configurations, pretreatment methods, quality of treated water, and economic issues have been investigated. With mixtures as complex as petroleum industry wastewaters, membrane fouling becomes a significant hurdle to implement the RO-based purification system. Operating the system within the critical flux range or adding chemicals, and/or pretreatment can usually control membrane fouling. Salt rejection of RO membranes can be 99% or higher.

Sté výročí narození Simone de Beauvoir

Czech Academy of Sciences Publication Activity Database

Uhde, Zuzana

2008-01-01

Roč. 44, č. 4 (2008), s. 797-799 ISSN 0038-0288 R&D Projects: GA AV ČR 1QS700280503 Institutional research plan: CEZ:AV0Z70280505 Keywords : Simone de Beauvoir * Feminism Subject RIV: AO - Sociology, Demography Impact factor: 0.427, year: 2008

Ab initio ro-vibronic spectroscopy of SiCCl (X{sup ~2}Π)

Energy Technology Data Exchange (ETDEWEB)

Brites, Vincent [Université d’Evry Val d’Essonne, Laboratoire Analyse et Modélisation pour la Biologie et l’Environnement, LAMBE CNRS UMR 8587, Boulevard F. Mitterrand, 91025 Evry Cedex (France); Mitrushchenkov, Alexander O.; Léonard, Céline, E-mail: celine.leonard@u-pem.fr [Université Paris-Est, Laboratoire Modélisation et Simulation Multi Echelle, MSME UMR 8208 CNRS, 5 bd Descartes, 77454 Marne-la-Vallée (France); Peterson, Kirk A. [Department of Chemistry, Washington State University, Pullman, Washington 99164 (United States)

2014-07-21

The full dimensional potential energy surfaces of the {sup 2}A{sup ′} and {sup 2}A{sup ′′} electronic components of X{sup ~2}Π SiCCl have been computed using the explicitly correlated coupled cluster method, UCCSD(T)-F12b, combined with a composite approach taking into account basis set incompleteness, core-valence correlation, scalar relativity, and higher order excitations. The spin-orbit and dipole moment surfaces have also been computed ab initio. The ro-vibronic energy levels and absorption spectrum at 5 K have been determined from variational calculations. The influence of each correction on the fundamental frequencies is discussed. An assignment is proposed for bands observed in the LIF experiment of Smith et al. [J. Chem. Phys. 117, 6446 (2002)]. The overall agreement between the experimental and calculated ro-vibronic levels is better than 7 cm{sup −1} which is comparable with the 10–20 cm{sup −1} resolution of the emission spectrum.

Multiple dose study of the combined radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

International Nuclear Information System (INIS)

Bleehen, N.M.; Newman, H.F.; Maughan, T.S.; Workman, P.

1989-01-01

The hypoxic cell radiosensitizers Ro 03-8799 and SR 2508 have different clinical toxicities. The former produces an acute but transient central nervous system syndrome, whereas the latter produces cumulative peripheral neuropathy. Following single dose studies, an escalating multiple dose schedule using both drugs in combination showed no unexpected adverse reactions at lower doses. This study identifies the clinical tolerance and pharmacokinetics when doses in the region of the maximal tolerated dose are given to 26 patients receiving infusions of 0.75 g/m2 Ro 03-8799 and 2 g/m2 SR 2508 three times per week. At 15 doses, 3/4 patients experienced WHO grade 2 peripheral neuropathy, whereas at 12 doses 1/9 developed grade 2 and 6/9 developed grade 1 neuropathies. This represents a lower dose of SR 2508 than can be given alone suggesting that some interaction between the two drugs does exist in terms of chronic peripheral neurotoxicity. Pharmacokinetic studies show no adverse interactions between the two drugs and minimal inter-patient variation. From bivariate analysis, cumulative AUC for Ro 03-8799 has the most significant correlation with the development of peripheral neuropathy. Tumor drug concentrations normalized to the administered dose show mean values of 34 micrograms/g Ro 03-8799 and 76 micrograms/g SR 2508 30 minutes after infusion. These could be expected to produce a single dose sensitizer enhancement ratio of 1.5. The combination of the two sensitizers at the maximum tolerable dose may be expected to give an increased therapeutic efficacy over either drug alone

Evropské mezinárodní právo soukromé a zamyšlení nad výročím Římských smluv

Czech Academy of Sciences Publication Activity Database

Pauknerová, Monika

2017-01-01

Roč. 156, č. 3 (2017), s. 179-191 ISSN 0231-6625 Institutional support: RVO:68378122 Keywords : European private international law * Czech private international law * international unification of private law Subject RIV: AG - Legal Sciences OBOR OECD: Law

VizieR Online Data Catalog: Spectral types of stars in CoRoT fields (Sebastian+, 2012)

Science.gov (United States)

Sebastian, D.; Guenther, E. W.; Schaffenroth, V.; Gandolfi, D.; Geier, S.; Heber, U.; Deleuil, M.; Moutou, C.

2012-03-01

Spectroscopic classification for 2950 O-, B-, and A-type stars in the CoRoT-fields IRa01, LRa01, and LRa02. Stars are named by their CoRoT-identifier and Coordinates are given. The visual magnitudes were obtained with the Wide Field Camera filter-system of the Isaac Newton Telescope at Roque de los Muchachos Observatory on La Palma and can be converted into Landolt standards, as shown in Deleuil et al. (2009AJ....138..649D). (1 data file).

Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints

Science.gov (United States)

Nadège, Lagarde

The availability of asteroseismic constraints for a large sample of red-giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations. We use a detailed spectroscopic study of 19 CoRoT red-giant stars (Morel et al. 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars. This study is already published in Lagarde et al. (2015)

Short-term forecasting of intermodal freight using ANNs and SVR: Case of the Port of Algeciras Bay

Energy Technology Data Exchange (ETDEWEB)

Moscoso Lopez, J.A.

2016-07-01

Forecasting of future intermodal traffic demand is very important for decision making in ports operations management. The use of accurate prediction tools is an issue that awakens a lot of interest among transport researchers. Intermodal freight forecasting plays an important role in ports management and in the planning of the principal port activities. Hence, the study is carried out under the motivation of knowing that modeling the freight transport flows could facilitate the management of the infrastructure and optimize the resources of the ports facilities. The use of advanced models for freight forecasting is essential to improve the port level-service and competitiveness. In this paper, two forecasting-models are presented and compared to predict the freight volume. The models developed and tested are based on Artificial Neural Networks and Support Vector Machines. Both techniques are based in a historical data and these methods forecast the daily weight of the freight with one week in advance. The performance of the models is evaluated on real data from Ro-Ro freight transport in the Port of Algeciras Bay. This work proposes and compares different approaches to determine the best prediction. In order to select the best model a multicomparison procedure is developed using several statistical test. The results of the assessed models show a promising tool to predict Ro-Ro transport flows with accuracy. (Author)

Modulation of cholinephosphotransferase activity in breast cancer cell lines by Ro5-4864, a peripheral benzodiazepine receptor agonist

International Nuclear Information System (INIS)

Akech, Jacqueline; Roy, Somdutta Sinha; Das, Salil K.

2005-01-01

Changes in phospholipid and fatty acid profile are hallmarks of cancer progression. Increase in peripheral benzodiazepine receptor expression has been implicated in breast cancer. The benzodiazepine, Ro5-4864, increases cell proliferation in some breast cancer cell lines. Biosynthesis of phosphatidylcholine (PC) has been identified as a marker for cells proliferating at high rates. Cholinephosphotransferase (CPT) is the terminal enzyme for the de novo biosynthesis of PC. We have addressed here whether Ro5-4864 facilitates some cancer causing mechanisms in breast cancer. We report that cell proliferation increases exponentially in aggressive breast cancer cell lines 11-9-1-4 and BT-549 when treated with nanomolar concentrations of Ro5-4864. This increase is seen within 24 h of treatment, consistent with the cell doubling time in these cells. Ro5-4864 also upregulates c-fos expression in breast cancer cell lines 11-9-1-4 and BT-549, while expression in non-tumorigenic cell line MCF-12A was either basal or slightly downregulated. We further examined the expression of the CPT gene in breast cancer (11-9-1-4, BT-549) and non-tumorigenic cell lines (MCF-12A, MCF-12F). We found that the CPT gene is overexpressed in breast cancer cell lines compared to the non-tumorigenic cell lines. Furthermore, the activity of CPT in forming PC is increased in the breast cancer cell lines cultured for 24 h. Additionally, we examined the CPT activity in the presence of nanomolar concentrations of Ro5-4864. Biosynthesis of PC was increased in breast cancer cell lines upon treatment. We therefore propose that Ro5-4864 facilitates PC formation, a process important in membrane biogenesis for proliferating cells

Beneficial phosphate recovery from reverse osmosis (RO) concentrate of an integrated membrane system using polymeric ligand exchanger (PLE).

Science.gov (United States)

Kumar, Manish; Badruzzaman, Mohammad; Adham, Samer; Oppenheimer, Joan

2007-05-01

Phosphorus (P) discharge to surface water is a major environmental problem. Wastewater treatment is targeted towards removal of this nutrient to prevent degradation of surface water. Integrated membrane systems (IMS) are increasingly being considered for wastewater reclamation, and provide excellent removal of P compounds. However, reverse osmosis (RO), which forms an integral part of these IMSs, concentrates most dissolved substances including P-species such as phosphates in the RO waste stream. In this study, removal of phosphate from this stream using polymeric ligand exchange (PLE) resins was investigated. Further, the possibility of phosphate recovery through struvite (MgNH(4)PO(4).6H(2)O) precipitation was tested. Struvite has been promoted as a slow release fertilizer in recent years. This study demonstrates that PLEs can be successfully used to remove phosphate from RO-concentrate, and to recover more than 85% of the adsorbed phosphorus from the exhausted media and precipitated as a beneficial product (struvite). The approach, presented in this study, suggests advantages of providing economic benefit from a waste product (RO) while avoiding phosphorus discharge to the environment.

Efficacy of an integrated continuing medical education (CME) and quality improvement (QI) program on radiation oncologist (RO) clinical practice

International Nuclear Information System (INIS)

Leong, Cheng Nang; Shakespeare, Thomas Philip; Mukherjee, Rahul K.; Back, Michael F.; Lee, Khai Mun; Lu, Jiade Jay; Wynne, Christopher J.; Lim, Keith; Tang, Johann; Zhang Xiaojian

2006-01-01

Purpose: There has been little radiation oncologist (RO)-specific research in continuing medical education (CME) or quality improvement (QI) program efficacy. Our aim was to evaluate a CME/QI program for changes in RO behavior, performance, and adherence to department protocols/studies over the first 12 months of the program. Methods and Materials: The CME/QI program combined chart audit with feedback (C-AWF), simulation review AWF (SR-AWF), reminder checklists, and targeted CME tutorials. Between April 2003 and March 2004, management of 75 patients was evaluated by chart audit with feedback (C-AWF) and 178 patients via simulation review audit (SR-AWF) using a validated instrument. Scores were presented, and case management was discussed with individualized educational feedback. RO behavior and performance was compared over the first year of the program. Results: Comparing the first and second 6 months, there was a significant improvement in mean behavior (12.7-13.6 of 14, p = 0.0005) and RO performance (7.6-7.9 of 8, p = 0.018) scores. Protocol/study adherence significantly improved from 90.3% to 96.6% (p = 0.005). A total of 50 actions were generated, including the identification of learning needs to direct CME tutorials, the systematic change of suboptimal RO practice, and the alteration of deficient management of 3% of patients audited during the program. Conclusion: An integrated CME/QI program combining C-AWF, SR-AWF, QI reminders, and targeted CME tutorials effectively improved targeted RO behavior and performance over a 12-month period. There was a corresponding increase in departmental protocol and study adherence

Y a-t-il eu un instant zéro ?

CERN Document Server

Klein, Etienne

2015-01-01

D'où vient l'univers ? Et d'où vient même qu'il y ait un univers ? Aura-t-il une fin ? Pourquoi les humains y sont-ils apparus ? Si ces questions nous obsèdent depuis toujours, celle de l'origine demeure la plus mystérieuse, la plus vertigineuse, d'où la profusion de discours — mythologiques, religieux ou philosophiques — qui tentent d'y répondre. C'est grâce à la science, aux découvertes de Newton, Galilée, Edwin Hubble, Alexandre Friedmann et Georges Lemaître, qu'on peut retracer le grand récit de l'univers, remonter son histoire à 13,7 milliards d'années, jusqu'à cette phase très dense et très chaude qu'on a appelée le big bang. Mais celui-ci n'est pas pour autant, comme on l'a imaginé, cette explosion originelle qui aurait créé tout ce qui existe. Cet instant zéro, peut-on le décrire, le penser, raconter d'où il peut bien provenir ? Et d'où serait venu l'univers d'avant le big bang ? Mystère ! Qu'il y ait eu origine ou pas, on ne part donc jamais de zéro. En parler, c'est p...

Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes.

Science.gov (United States)

Lee, Hye-Jin; Kim, Hyung-Eun; Lee, Changha

2017-03-01

Combinations of Cu(II) with hydroxylamine (HA) and hydrogen peroxide (H 2 O 2 ) (i.e., Cu(II)/HA, Cu(II)/H 2 O 2 , and Cu(II)/HA/H 2 O 2 systems) were investigated for the control of P. aeruginosa biofilms on reverse osmosis (RO) membranes. These Cu(II)-based disinfection systems effectively inactivated P. aeruginosa cells, exhibiting different behaviors depending on the state of bacterial cells (planktonic or biofilm) and the condition of biofilm growth and treatment (normal or pressurized condition). The Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems were the most effective reagents for the inactivation of planktonic cells. However, these systems were not effective in inactivating cells in biofilms on the RO membranes possibly due to the interactions of Cu(I) with extracellular polymeric substances (EPS), where biofilms were grown and treated in center for disease control (CDC) reactors. Different from the results using CDC reactors, in a pressurized cross-flow RO filtration unit, the Cu(II)/HA/H 2 O 2 treatment significantly inactivated biofilm cells formed on the RO membranes, successfully recovering the permeate flux reduced by the biofouling. The pretreatment of feed solutions by Cu(II)/HA and Cu(II)/HA/H 2 O 2 systems (applied before the biofilm formation) effectively mitigated the permeate flux decline by preventing the biofilm growth on the RO membranes. Copyright © 2016 Elsevier Ltd. All rights reserved.

Removal of Pharmaceutical and Personal Care Products (PPCPs) from Municipal Waste Water with Integrated Membrane Systems, MBR-RO/NF.

Science.gov (United States)

Wang, Yonggang; Wang, Xu; Li, Mingwei; Dong, Jing; Sun, Changhong; Chen, Guanyi

2018-02-05

This study focuses on the application of combining membrane bioreactor (MBR) treatment with reverse osmosis (RO) or nanofiltration (NF) membrane treatment for removal of pharmaceuticals and personal care products (PPCPs) in municipal wastewater. Twenty-seven PPCPs were measured in real influent with lowest average concentration being trimethoprim (7.12 ng/L) and the highest being caffeine (18.4 ng/L). The results suggest that the MBR system effectively removes the PPCPs with an efficiency of between 41.08% and 95.41%, and that the integrated membrane systems, MBR-RO/NF, can achieve even higher removal rates of above 95% for most of them. The results also suggest that, due to the differences in removal mechanisms of NF/RO membrane, differences of removal rates exist. In this study, the combination of MBR-NF resulted in the removal of 13 compounds to below detection limits and MBR-RO achieved even better results with removal of 20 compounds to below detection limits.

RoCoMAR: Robots' Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

Science.gov (United States)

Van Le, Duc; Oh, Hoon; Yoon, Seokhoon

2013-01-01

In a practical deployment, mobile sensor network (MSN) suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots' Controllable Mobility Aided Routing) that uses robotic nodes' controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay. PMID:23881134

RoCoMAR: Robots’ Controllable Mobility Aided Routing and Relay Architecture for Mobile Sensor Networks

Directory of Open Access Journals (Sweden)

Seokhoon Yoon

2013-07-01

Full Text Available In a practical deployment, mobile sensor network (MSN suffers from a low performance due to high node mobility, time-varying wireless channel properties, and obstacles between communicating nodes. In order to tackle the problem of low network performance and provide a desired end-to-end data transfer quality, in this paper we propose a novel ad hoc routing and relaying architecture, namely RoCoMAR (Robots’ Controllable Mobility Aided Routing that uses robotic nodes’ controllable mobility. RoCoMAR repeatedly performs link reinforcement process with the objective of maximizing the network throughput, in which the link with the lowest quality on the path is identified and replaced with high quality links by placing a robotic node as a relay at an optimal position. The robotic node resigns as a relay if the objective is achieved or no more gain can be obtained with a new relay. Once placed as a relay, the robotic node performs adaptive link maintenance by adjusting its position according to the movements of regular nodes. The simulation results show that RoCoMAR outperforms existing ad hoc routing protocols for MSN in terms of network throughput and end-to-end delay.

Tourismusbüro von Dubai in der Schweiz & Österreich: Analyse des Business Plan & Budget 2013

OpenAIRE

Wyss, Anja; Stampfli, Michèle

2014-01-01

Das Department of Tourism and Commerce Marketing of Dubai (DTCM) hat in der Schweiz ein Auslandbüro, das für die Märkte Schweiz und Österreich zuständig ist. Dieses Tourismusbüro ist in den beiden Ländern mehrheitlich für die touristische sowohl als auch für die ökonomische Vermarktung der Destination Dubai zuständig. Um die Marketingaktivitäten im Groben zu planen, wird jährlich ein Marketingkonzept erstellt, das jedoch nicht auf statistischen Werten oder einer detaillierten Marktanalyse bas...

The TROVE module: a common element in Telomerase, Ro and Vault ribonucleoproteins.

Science.gov (United States)

Bateman, Alex; Kickhoefer, Valerie

2003-10-16

Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. The TROVE module--Telomerase, Ro and Vault module--is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

Paleogeothermal record of the Emeishan mantle plume: evidences from borehole Ro data in the Sichuan basin, SW China

Science.gov (United States)

Hu, S.

2013-12-01

The Emeishan basalt province located in the southwest of China is widely accepted to be a result of the eruption of a mantle plume at the time of middle-late Permian. If it was a mantle plume, the ambient sedimentary rocks must be heated up during the development of the mantle plume and this thermal effect must be recorded by some geothermometers in the country rocks. The vitrinite reflectance (Ro) data as a maximum paleotemperature recorder from boreholes in Sichuan basin was employed to expose the thermal regime related to the proposed Emeishan mantle plume. The Ro profiles from boreholes which drilled close to the Emeishan basalts shows a ';dog-leg' (break) style at the unconformity between the middle and the upper Permian, and the Ro profiles in the lower subsection (pre-middle Permian) shows a significantly higher slopes (gradients) than those in the upper subsection. In contrast, those Ro profiles from boreholes far away from the center of the basalt province have no break at the uncomformity. Based on the chemical kinetic model of Ro, the paleo-temperature gradients for the upper and the lower subsections in different boreholes, as well as the erosion at the unconformity between the middle and the upper Permian, were reconstructed to reveal the variations of the temperature gradients and erosion thickness with geological time and space. Both the thermal regime and the erosion thickness together with their spatial variation (structure) provide strong geothermal evidence for the existence of the Emeishan mantle plume in the middle-late Permian.

Metabolite analysis of [11C]Ro15-4513 in mice, rats, monkeys and humans

International Nuclear Information System (INIS)

Kida, T.; Noguchi, J.; Zhang, M.-R.; Suhara, T.; Suzuki, K.

2003-01-01

We performed in vitro and in vivo assays of the metabolism of [ 11 C]Ro15-4513 over time in the plasma of mice, rats, monkeys and humans, using a radio-HPLC equipped with a sensitive positron detector, in order to compare the metabolic rates of the radiopharmaceutical agent among the different animal species and to establish a highly sensitive analytical method for the radiotracer agent. We also examined the metabolism of [ 11 C]Ro15-4513 in the brain tissue of mice and rats. The analytical method used in this study permitted detection of even extremely low levels of radioactivity (approximately 5,000 dpm). In vitro experiments revealed that [ 11 C]Ro15-4513 in the blood was metabolized to hydrolysate [ 11 C]A. The species were classified in descending order of the metabolic rate of the radiotracer in vitro as follows; mice, rats, and monkeys/humans. In the in vitro experiment, the percentage of the unchanged drug in the plasma at 60 minutes postdose was 9% in mice, 70% in rats, 97% in monkeys, and 98% in humans. In vivo metabolite analysis in the blood showed the presence of two radioactive metabolites, consisting of one hydrolysate [ 11 C]A and another unidentified substance. The species were classified in descending order of the metabolic rate of the radiotracer in vivo as follows; mice, rats/humans, and monkeys. The percentage of the unchanged drug in the plasma was 6% in mice, 21% in rats, 26% in humans, and 40% in monkeys. Furthermore, the in vitro and in vivo experiments conducted to analyze the metabolism of [ 11 C]Ro15-4513 in the brain tissue of mice and rats revealed that the radiotracer was metabolized to some extent in the brain tissue of these animals. In the in vivo experiment, the percentage of the unchanged drug at 60 min postdose was 86% in the brain tissue of mice and 88% in the brain tissue of rats, while in the in vitro experiment, the corresponding percentage was 93% in mice, and 91% in rats

Partial agonist of benzodiazepine receptors Ro 19-2088 elicits withdrawal symptoms after short-term administration in immature rats

Czech Academy of Sciences Publication Activity Database

Kubová, Hana; Mareš, Pavel

2012-01-01

Roč. 61, č. 3 (2012), s. 319-323 ISSN 0862-8408 R&D Projects: GA ČR(CZ) GA305/09/0846; GA ČR(CZ) GBP304/12/G069 Institutional research plan: CEZ:AV0Z50110509 Institutional support: RVO:67985823 Keywords : Ro 19-2088 * iatrogenic withdrawal * pentylentetrazol-induced seizures * immature rats Subject RIV: FH - Neurology Impact factor: 1.531, year: 2012

Inventory of Onshore Hydrocarbon Seeps in Romania (HYSED-RO Database

Directory of Open Access Journals (Sweden)

Artur Ionescu

2017-06-01

Full Text Available Seeps are the expression of the migration of hydrocarbons from subsurface accumulations to the surface in sedimentary basins. They may represent an important indication of the presence of petroleum (gas and oil reservoirs and faults, and are a natural source of greenhouse gas (methane and atmospheric pollutants (ethane, propane to the atmosphere. Romania is one of the countries with the largest number of seeps in the world, due to the high petroleum potential and active tectonics. Based on a review of the available literature, and on the field surveys performed by the authors during the last 17 years, we report the first comprehensive GIS-based inventory of 470 seeps in Romania (HYSED-RO, including gas seeps (10.4% of the total, oil seeps (11.7%, mud volcanoes (50.4%, gas-rich springs (12.6%, asphalt (solid seeps (4.3%, unclassified manifestations (4.0%, and uncertain seeps (6.6%. Seeps are typically located in correspondence with major faults and vertical and fractured stratigraphic contacts associated to petroleum reservoirs (anticlines in low heat flow areas, and their gas-geochemistry reflects that of the subsurface reservoirs. The largest and most active seeps occur in the Carpathian Foredeep, where they release thermogenic gas, and subordinately in the Transylvanian Basin, where gas is mainly microbial. HYSED-RO may represent a key reference for baseline characterization prior to subsurface petroleum extraction, for environmental studies, and atmospheric greenhouse gas emission estimates in Romania.

Ke stému ročníku Chemických Listů

Czech Academy of Sciences Publication Activity Database

Holý, Petr

2006-01-01

Roč. 100, č. 4 (2006), s. 227-232 ISSN 0009-2770 Keywords : history and significance of the journal * notable members of editorial board Subject RIV: CC - Organic Chemistry Impact factor: 0.431, year: 2006

Brain perfusion imaging using a Reconstruction-of-Difference (RoD) approach for cone-beam computed tomography

Science.gov (United States)

Mow, M.; Zbijewski, W.; Sisniega, A.; Xu, J.; Dang, H.; Stayman, J. W.; Wang, X.; Foos, D. H.; Koliatsos, V.; Aygun, N.; Siewerdsen, J. H.

2017-03-01

Purpose: To improve the timely detection and treatment of intracranial hemorrhage or ischemic stroke, recent efforts include the development of cone-beam CT (CBCT) systems for perfusion imaging and new approaches to estimate perfusion parameters despite slow rotation speeds compared to multi-detector CT (MDCT) systems. This work describes development of a brain perfusion CBCT method using a reconstruction of difference (RoD) approach to enable perfusion imaging on a newly developed CBCT head scanner prototype. Methods: A new reconstruction approach using RoD with a penalized-likelihood framework was developed to image the temporal dynamics of vascular enhancement. A digital perfusion simulation was developed to give a realistic representation of brain anatomy, artifacts, noise, scanner characteristics, and hemo-dynamic properties. This simulation includes a digital brain phantom, time-attenuation curves and noise parameters, a novel forward projection method for improved computational efficiency, and perfusion parameter calculation. Results: Our results show the feasibility of estimating perfusion parameters from a set of images reconstructed from slow scans, sparse data sets, and arc length scans as short as 60 degrees. The RoD framework significantly reduces noise and time-varying artifacts from inconsistent projections. Proper regularization and the use of overlapping reconstructed arcs can potentially further decrease bias and increase temporal resolution, respectively. Conclusions: A digital brain perfusion simulation with RoD imaging approach has been developed and supports the feasibility of using a CBCT head scanner for perfusion imaging. Future work will include testing with data acquired using a 3D-printed perfusion phantom currently and translation to preclinical and clinical studies.

Oscillations in roAp and & Scuti Stars : Theory and observations

OpenAIRE

Pinheiro, Fernando Jorge Gutiérrez

1999-01-01

As estrelas d Scuti e as estrelas roAp encontram-se na região da Faixa de Instabilidade das Cefeides que é atravessada pela Sequência principal. Cada tipo de estrelas apresenta frequências de oscilação que o outro género de estrelas não apresenta. Estas oscilações dependem da estrutura das estrelas, e podem ser descritas pelos modelos apropriados.De modo inverso, podemos a partir de observações obter as características de uma estrela, usando os modelos adequados.Discutiremos os modos de obter...

Mathematical Verification for Transmission Performance of Centralized Lightwave WDM-RoF-PON with Quintuple Services Integrated in Each Wavelength Channel

Directory of Open Access Journals (Sweden)

Shuai Chen

2015-01-01

Full Text Available Wavelength-division-multiplexing passive-optical-network (WDM-PON has been recognized as a promising solution of the “last mile” access as well as multibroadband data services access for end users, and WDM-RoF-PON, which employs radio-over-fiber (RoF technique in WDM-PON, is even a more attractive approach for future broadband fiber and wireless access for its strong availability of centralized multiservices transmission operation and its transparency for bandwidth and signal modulation formats. As for multiservices development in WDM-RoF-PON, various system designs have been reported and verified via simulation or experiment till now, and the scheme with multiservices transmitted in each single wavelength channel is believed as the one that has the highest bandwidth efficiency; however, the corresponding mathematical verification is still hard to be found in state-of-the-art literature. In this paper, system design and data transmission performance of a quintuple services integrated WDM-RoF-PON which jointly employs carrier multiplexing and orthogonal modulation techniques, have been theoretically analyzed and verified in detail; moreover, the system design has been duplicated and verified experimentally and the theory system of such WDM-RoF-PON scheme has thus been formed.

A modified CoRoT detrend algorithm and the discovery of a new planetary companion

Science.gov (United States)

Boufleur, Rodrigo C.; Emilio, Marcelo; Janot-Pacheco, Eduardo; Andrade, Laerte; Ferraz-Mello, Sylvio; do Nascimento, José-Dias, Jr.; de La Reza, Ramiro

2018-01-01

We present MCDA, a modification of the COnvection ROtation and planetary Transits (CoRoT) detrend algorithm (CDA) suitable to detrend chromatic light curves. By means of robust statistics and better handling of short-term variability, the implementation decreases the systematic light-curve variations and improves the detection of exoplanets when compared with the original algorithm. All CoRoT chromatic light curves (a total of 65 655) were analysed with our algorithm. Dozens of new transit candidates and all previously known CoRoT exoplanets were rediscovered in those light curves using a box-fitting algorithm. For three of the new cases, spectroscopic measurements of the candidates' host stars were retrieved from the ESO Science Archive Facility and used to calculate stellar parameters and, in the best cases, radial velocities. In addition to our improved detrend technique, we announce the discovery of a planet that orbits a 0.79_{-0.09}^{+0.08} R⊙ star with a period of 6.718 37 ± 0.000 01 d and has 0.57_{-0.05}^{+0.06} RJ and 0.15 ± 0.10 MJ. We also present the analysis of two cases in which parameters found suggest the existence of possible planetary companions.

Adsorção dos corantes RO16, RR2 e RR141 utilizando lodo residual da indústria têxtil Adsorption of dyes RO16, RR2 and RR141 using residual sludge of textile industry

Directory of Open Access Journals (Sweden)

Andressa Regina Vasques

2011-09-01

Full Text Available A adsorção é uma das técnicas empregadas com sucesso para remoção efetiva da cor presente em efluentes têxteis. Com o objetivo de avaliar os diferentes parâmetros adsortivos, bem como determinar a eficiência de um adsorvente alternativo desenvolvido a partir de lodo residual têxtil na remoção de corantes, foram determinadas curvas de cinética de adsorção e isotermas. Por meio dos dados cinéticos e de equilíbrio obtidos, verificou-se que a 25ºC a adsorção foi favorável para todos os corantes, sendo esta a melhor condição para os corantes RO16 e RR2 na ausência de sais. Para o corante RR141, a adição de NaCl aumentou a capacidade de adsorção do adsorvente no equilíbrio e a adição de Na2SO4 favoreceu a adsorção para o corante RO16, ao contrário do que se observou para os outros dois corantes. A quantidade máxima de corante adsorvida por unidade de massa de adsorvente (q max nas melhores condições adsortivas para os corantes RO16, RR2 e RR141 foi de 81,30, 53,48 e 78,74 mg.g-1, respectivamente.The adsorption is one of the techniques that have been successfully used for effective removal of the dyes present in textile effluents. With the objective to evaluate the different adsorptive parameters, as well as determining the efficiency of one alternative adsorbent in the removal of dyes, kinetics and equilibrium data of adsorption were determined. By the kinetic data and of equilibrium, it was verified that the adsorption was favorable for all the dyes in 25ºC, being the best condition for the dye RO16 and RR2 in the total absence of salt. For the dye RR141, the addition of NaCl increased the adsorption capacity of adsorbent in the equilibrium and the addition of Na2SO4 favored the adsorption for the dye RO16, in contrast to what was observed for the two other dyes. The maximum quantity of dye adsorbed per unit mass of adsorbent (q max in the best adsorptive conditions for the dyes RO16, RR2 and RR141 was of 81

Phase I study of the combination of two hypoxic cell radiosensitizers, Ro 03-8799 and SR-2508: toxicity and pharmacokinetics

International Nuclear Information System (INIS)

Newman, H.F.; Bleehen, N.M.; Workman, P.

1986-01-01

The hypoxic cell radiosensitizer Ro 03-8799 produces acute central nervous system toxicity which limits repeated doses of the drug to 0.75 g/m 2 , but peripheral neuropathy does not occur. SR-2508 causes no acute effects at doses greater than 3.0 g/m 2 , but causes peripheral neuropathy at cumulative doses of 30 g/m 2 . By combining maximum tolerated doses of each agent, it may be possible to increase efficacy, but not toxicity. Escalating single doses of Ro 03-8799 and SR-2508 were administered to 10 patients. The drugs were infused together in 50 ml of 0.9% saline over 10 min, beginning at 0.5 g/m 2 of each agent, and proceeding to a fixed dose of 0.75 g/m 2 Ro 03-8799 with 0.5, 1.0, 2.0, and 3.0 g/m 2 SR-2508. Four patients experienced the expected acute syndrome related to Ro 03-8799, but the incidence was not increased by escalating doses of SR-2508, and no peripheral neuropathy was seen. Plasma and urine pharmacokinetic studies showed that no drug interaction occurred. Six patients have been given a 9-dose regime over a 3 week period, using 0.75 g/m 2 Ro 03-8799 and escalating doses of 0.5, 1.0, and 1.5 g/m2 SR-2508. All exhibited the expected acute side effects related to Ro 03-8799, but with no increase at the higher doses of SR-2508. No other toxicity was seen. Plasma pharmacokinetics performed at the beginning and end of the schedule were similar. Biopsies were taken from six superficial tumors following combined radiosensitizer administration. Mean tumor concentrations over the 30 min following the end of infusion were 30 and 72 micrograms/g for Ro 03-8799 and SR-2508, respectively. These values would be expected to translate into an approximate single dose sensitizer enhancement ratio of 1.5 to 1.6, offering a significant gain over the enhancement possible with the drugs given alone

Benzodiazepine receptor binding in vivo with (/sup 3/)-Ro 15-1788

Energy Technology Data Exchange (ETDEWEB)

Goeders, N.E.; Kuhar, M.J.

1985-07-29

In vivo benzodiazepine receptor binding has generally been studied by ex vivo techniques. In this investigation, the authors identify the conditions where (/sup 3/H)-Ro 15-1788 labels benzodiazepine receptors by true in vivo binding, i.e. where workable specific to nonspecific ratios are obtained in intact tissues without homogenization or washing. (/sup 3/H)-Flunitrazepam and (/sup 3/H)-clonazepam did not exhibit useful in vivo receptor binding. 39 references, 5 figures, 1 table.

Review of serious events in cases of (suspected) child abuse and/or neglect: A RoSE by any other name?

Science.gov (United States)

Raman, Shanti; Maiese, Michelle; Vasquez, Viviana; Gordon, Paola; Jones, Jennifer M

2017-08-01

Child abuse and neglect (CAN) cases presenting to health-services may be complex; when things go seriously wrong such as a child death or near miss, cases are reviewed and health-services and professionals subject to intense scrutiny. While there are a variety of mechanisms to review critical incidents in health-services no formal process for the review of cases where child protection is the primary concern exists in Australia. We aimed to develop a systematic process to review serious events in cases of suspected CAN across two health districts in Sydney, so that shared learnings could fuel system change. Drawing upon mapping, case review, literature findings and using quality improvement methodology, we developed a model named Review of Serious Events (RoSE), in suspected cases of CAN. The RoSE model has the key features of: being child focused; seeking to examine care over a period of time; using child protection staff as lead reviewers; involving health professionals/services in the review who have been involved with the child; and actioning systems change at local levels. The RoSE model was trialled through 2014-2015. Eight cases were reviewed using RoSE; cases were similar to those reviewed prior to having a model. Participant feedback from RoSE group processes was overwhelmingly positive; outputs were transparent and accessible to key stakeholders, there was mixed progress with implementation. The RoSE model is a serious case review process that is strongly child-focused, is both investigative and reflective, led by child protection experts; and can be adapted to other settings and systems. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

The TROVE module: A common element in Telomerase, Ro and Vault ribonucleoproteins

Directory of Open Access Journals (Sweden)

Bateman Alex

2003-10-01

Full Text Available Abstract Background Ribonucleoproteins carry out a variety of important tasks in the cell. In this study we show that a number of these contain a novel module, that we speculate mediates RNA-binding. Results The TROVE module – Telomerase, Ro and Vault module – is found in TEP1 and Ro60 the protein components of three ribonucleoprotein particles. This novel module, consisting of one or more domains, may be involved in binding the RNA components of the three RNPs, which are telomerase RNA, Y RNA and vault RNA. A second conserved region in these proteins is shown to be a member of the vWA domain family. The vWA domain in TEP1 is closely related to the previously recognised vWA domain in VPARP a second component of the vault particle. This vWA domain may mediate interactions between these vault components or bind as yet unidentified components of the RNPs. Conclusions This work suggests that a number of ribonucleoprotein components use a common RNA-binding module. The TROVE module is also found in bacterial ribonucleoproteins suggesting an ancient origin for these ribonucleoproteins.

123I-labeling and evaluation of Ro 43-0463, a SPET tracer for MAO-B imaging

International Nuclear Information System (INIS)

Beer, H.-F.; Rossetti, I.; Frey, L.D.; Hasler, P.H.; Schubiger, P.A.

1995-01-01

Using the copper assisted halogen exchange the MAO-B inhibitor Ro 43-0463, N-(2-aminoethyl)-5-iodo-2-pyridinecarboxamide, was labelled with 123 I as well as with 125 I to allow in vitro and in vivo investigations including SPET with healthy volunteers. Ro 43-0463 is known to inhibit reversibly and specifically MAO-B, having an ic 50 of 3 x 10 -8 Mol/L. The labeling in the presence of CuSO 4 and ascorbic acid was optimised, varying time (30 to 105 min), precursor concentration (1-3.5 mg) and temperature (130-200 deg. C). The labeling yield ranged between 60 and 70%. Purification was achieved with Lichrosorb RP-18 (5 μm, 250 x 8 mm) and 1.5 mL/min 0.36 M H 3 PO 4 /EtOH (97(3)) [0.01 M (NH 4 ) 2 HPO 4 ]. After neutralisation and sterile filtration the final activity concentration ranged between 18.5 and 37 MBq/mL. Biodistribution studies showed a brain to blood ratio greater than 1 within 1 h p.i. The main radiation burden calculated from these animal data is to alimentary and excretory organs and the ovaries. Autoradiography was performed using rat brain slices and 5 nM [ 125 I]Ro 43-0463 in TRIS-buffer pH 7.4 for 90 min at 20 deg. C. Its radioactivity pattern corresponds to the known distribution of MAO-B in the rat brain. By displacement with L-deprenyl the highly specific binding of Ro 43-0463 was proven in vitro. SPECT studies with normal volunteers corresponded with the pattern found in autoradiography

An Intercomparison of GPS RO Retrievals with Colocated Analysis and In Situ Observations within Tropical Cyclones

Directory of Open Access Journals (Sweden)

Henry R. Winterbottom

2010-01-01

Full Text Available Observations from four Global Position System (GPS Radio Occultation (RO missions: Global Positioning System/Meteorology, CHAallenging Minisatellite Payload, Satellite de Aplicaciones Cientificas-C, and Constellation Observing System for Meteorology, Ionosphere and Climate and Taiwan's FORMOsa SATellite Mission #3 (COSMIC/FORMOSAT-3 are collected within a 600 km radius and ±180 minute temporal window of all observed tropical cyclones (TCs from 1995 to 2006 that were recorded in the global hurricane best-track reanalysis data set (Jarvinen et al. (1984; Davis et al. (1984. A composite analysis of tropical cyclone radial mean temperature and water vapor profiles is carried out using the GPS RO retrievals which are colocated with global analysis profiles and available in situ radiosonde observations. The differences between the respective observations and analysis profiles are quantified and the preliminary results show that the observations collected within TCs correspond favorably with both the analysis and radiosonde profiles which are colocated. It is concluded that GPS RO observations will contribute significantly to the understanding and modeling of TC structures, especially those related to vertical variability of the atmospheric state within TCs.

An Automated Planning Model for RoF Heterogeneous Wireless Networks

DEFF Research Database (Denmark)

Shawky, Ahmed; Bergheim, Hans; Ragnarsson, Ólafur

2010-01-01

The number of users in wireless WANs is increasing like never before, at the same time as the bandwidth demands by users increase.The structure of the third generation Wireless WANs makes it expensive for Wireless ISPs to meet these demands.The FUTON architecture is a RoF heterogeneous wireless...... network architecture under development,that will be cheaper to deploy and operate.This paper shows a method to plan an implementation of this architecture.The planning is done as automatic as possible,covering radio planning, fiber planning and network dimensioning. The out come of the paper is a planning...

A 0.8-2.4 μm Transmission spectrum of the hot Jupiter CoRoT-1b

Energy Technology Data Exchange (ETDEWEB)

Schlawin, E.; Herter, T. [Astronomy Department, Cornell University, Ithaca, NY 14853 (United States); Zhao, M. [Department of Astronomy, Pennsylvania State University, University Park, PA 16802 (United States); Teske, J. K. [Astronomy Department, The University of Arizona, Tucson, AZ 85721 (United States)

2014-03-01

Hot Jupiters with brightness temperatures ≳2000 K can have TiO and VO molecules as gaseous species in their atmospheres. The TiO and VO molecules can potentially induce temperature inversions in hot Jupiter atmospheres and also have an observable signature of large optical to infrared transit depth ratios. Previous transmission spectra of very hot Jupiters have shown a lack of TiO and VO, but only in planets that also appear to lack temperature inversions. We measure the transmission spectrum of CoRoT-1b, a hot Jupiter that was predicted to have a temperature inversion potentially due to significant TiO and VO in its atmosphere. We employ the multi-object spectroscopy method using the SpeX and MORIS instruments on the Infrared Telescope Facility (IRTF) and the Gaussian process method to model red noise. By using a simultaneous reference star on the slit for calibration and a wide slit to minimize slit losses, we achieve transit depth precision of 0.03%-0.09%, comparable to the atmospheric scale height but detect no statistically significant molecular features. We combine our IRTF data with optical CoRoT transmission measurements to search for differences in the optical and near-infrared absorption that would arise from TiO/VO. Our IRTF spectrum and the CoRoT photometry disfavor a TiO/VO-rich spectrum for CoRoT-1b, suggesting that the atmosphere has another absorber that could create a temperature inversion or that the blackbody-like emission from the planet is due to a spectroscopically flat cloud, dust, or haze layer that smoothes out molecular features in both CoRoT-1b's emission and transmission spectra. This system represents the faintest planet hosting star (K = 12.2) with a measured planetary transmission spectrum.

Inhibitory Effects of Cytosolic Ca2+ Concentration by Ginsenoside Ro Are Dependent on Phosphorylation of IP3RI and Dephosphorylation of ERK in Human Platelets

Directory of Open Access Journals (Sweden)

Hyuk-Woo Kwon

2015-01-01

Full Text Available Intracellular Ca2+ ([Ca2+]i is platelet aggregation-inducing molecule and is involved in activation of aggregation associated molecules. This study was carried out to understand the Ca2+-antagonistic effect of ginsenoside Ro (G-Ro, an oleanane-type saponin in Panax ginseng. G-Ro, without affecting leakage of lactate dehydrogenase, dose-dependently inhibited thrombin-induced platelet aggregation, and the half maximal inhibitory concentration was approximately 155 μM. G-Ro inhibited strongly thrombin-elevated [Ca2+]i, which was strongly increased by A-kinase inhibitor Rp-8-Br-cAMPS compared to G-kinase inhibitor Rp-8-Br-cGMPS. G-Ro increased the level of cAMP and subsequently elevated the phosphorylation of inositol 1, 4, 5-triphosphate receptor I (IP3RI (Ser1756 to inhibit [Ca2+]i mobilization in thrombin-induced platelet aggregation. Phosphorylation of IP3RI (Ser1756 by G-Ro was decreased by PKA inhibitor Rp-8-Br-cAMPS. In addition, G-Ro inhibited thrombin-induced phosphorylation of ERK 2 (42 kDa, indicating inhibition of Ca2+ influx across plasma membrane. We demonstrate that G-Ro upregulates cAMP-dependent IP3RI (Ser1756 phosphorylation and downregulates phosphorylation of ERK 2 (42 kDa to decrease thrombin-elevated [Ca2+]i, which contributes to inhibition of ATP and serotonin release, and p-selectin expression. These results indicate that G-Ro in Panax ginseng is a beneficial novel Ca2+-antagonistic compound and may prevent platelet aggregation-mediated thrombotic disease.

RoMo: An efficient strategy for functional mosaic analysis via stochastic Cre recombination and gene targeting in the ROSA26 locus.

Science.gov (United States)

Movahedi, Kiavash; Wiegmann, Robert; De Vlaminck, Karen; Van Ginderachter, Jo A; Nikolaev, Viacheslav O

2018-07-01

Functional mosaic analysis allows for the direct comparison of mutant cells with differentially marked control cells in the same organism. While this offers a powerful approach for elucidating the role of specific genes or signalling pathways in cell populations of interest, genetic strategies for generating functional mosaicism remain challenging. We describe a novel and streamlined approach for functional mosaic analysis, which combines stochastic Cre/lox recombination with gene targeting in the ROSA26 locus. With the RoMo strategy a cell population of interest is randomly split into a cyan fluorescent and red fluorescent subset, of which the latter overexpresses a chosen transgene. To integrate this approach into high-throughput gene targeting initiatives, we developed a procedure that utilizes Gateway cloning for the generation of new targeting vectors. RoMo can be used for gain-of-function experiments or for altering signaling pathways in a mosaic fashion. To demonstrate this, we developed RoMo-dnGs mice, in which Cre-recombined red fluorescent cells co-express a dominant-negative Gs protein. RoMo-dnGs mice allowed us to inhibit G protein-coupled receptor activation in a fraction of cells, which could then be directly compared to differentially marked control cells in the same animal. We demonstrate how RoMo-dnGs mice can be used to obtain mosaicism in the brain and in peripheral organs for various cell types. RoMo offers an efficient new approach for functional mosaic analysis that extends the current toolbox and may reveal important new insights into in vivo gene function. © 2018 Wiley Periodicals, Inc.

Water Quality of Hills Water, Supply Water and RO Water Machine at Ulu Yam Selangor

Science.gov (United States)

Ngadiman, N.; ‘I Bahari, N.; Kaamin, M.; Hamid, N. B.; Mokhtar, M.; Sahat, S.

2016-07-01

The rapid development resulted in the deterioration of the quality of drinking water in Malaysia. Recognizing the importance of water quality, new alternatives for drinking water such as mineral water processing from reverse osmosis (RO) machine become more popular. Hence, the demand for mineral water, natural spring water or water from the hills or mountains rose lately. More consumers believed the quality of these spring water better than other source of drinking water. However, the quality of all the drinking water sources is to meet the required quality standard. Therefore, this paper aims to measure the quality of the waters from hills, from RO machine and the water supply in Ulu Yam, Selangor Batang Kali, Malaysia. The water quality was determined based on following parameters: ammoniacal nitrogen (NH3), iron (Fe), turbidity (NTU) and pH. The results show that the water from hills has better quality compared to water supply and water from RO machine. The value of NH3 ranged from 0.03 mg/L- 0.67 mg/L; Fe was from 0.03mg/L - 0.12 mg/L, turbidity at 0.42 NTU - 0.88 NTU and pH is at 6.60 - 0.71. Based on the studied parameters, all three types of water are fit for drinking and have met the required national drinking water quality standard.

Three-gradual pilot unit of JP3RO for cleanings and concentration of radioactive sewage by method of upturned osmosis

International Nuclear Information System (INIS)

Chmielewski, A.G.; Harasimowicz, M.; Tyminski, B.; Zakrzewska-Trznadel, G.

2001-01-01

For many years the Institute of Nuclear Chemistry and Technology has worked on the application of different membrane processes to nuclear technology. The experiments with ultrafiltration, ultrafiltration combined with chemical complexation, membrane distillation and reverse osmosis were conducted. Reverse osmosis (RO) as a method for liquid radioactive waste treatment has been examined at laboratory and pilot plant installations. Thr purification of radioactive model solutions as well as liquid low and medium level radioactive waste samples has been examined with various reverse osmotic modules equipped with thin composite polymeric membranes. The experience with the process led to design and construction of the JP3RO industrial plant, 1 m 3 capacity, composed of three RO stages. On the basis of earlier investigations, membrane modules were selected for the plant. The installation is described in this paper, and the results of experiments are presented. The JP3RO installation was included into the system of liquid low and medium-level radioactive wastes treatment at Institute of Nuclear Energy in Swierk. (author)

Symmetry-Adapted Ro-vibrational Basis Functions for Variational Nuclear Motion Calculations: TROVE Approach.

Science.gov (United States)

Yurchenko, Sergei N; Yachmenev, Andrey; Ovsyannikov, Roman I

2017-09-12

We present a general, numerically motivated approach to the construction of symmetry-adapted basis functions for solving ro-vibrational Schrödinger equations. The approach is based on the property of the Hamiltonian operator to commute with the complete set of symmetry operators and, hence, to reflect the symmetry of the system. The symmetry-adapted ro-vibrational basis set is constructed numerically by solving a set of reduced vibrational eigenvalue problems. In order to assign the irreducible representations associated with these eigenfunctions, their symmetry properties are probed on a grid of molecular geometries with the corresponding symmetry operations. The transformation matrices are reconstructed by solving overdetermined systems of linear equations related to the transformation properties of the corresponding wave functions on the grid. Our method is implemented in the variational approach TROVE and has been successfully applied to many problems covering the most important molecular symmetry groups. Several examples are used to illustrate the procedure, which can be easily applied to different types of coordinates, basis sets, and molecular systems.

New global electron density observations from GPS-RO in the D- and E-Region ionosphere

Science.gov (United States)

Wu, Dong L.

2018-06-01

A novel retrieval technique is developed for electron density (Ne) in the D- and E-region (80-120 km) using the high-quality 50-Hz GPS radio occultation (GPS-RO) phase measurements. The new algorithm assumes a slow, linear variation in the F-region background when the GPS-RO passes through the D- and E-region, and extracts the Ne profiles at 80-130 km from the phase advance signal caused by Ne. Unlike the conventional Abel function, the new approach produces a sharp Ne weighting function in the lower ionosphere, and the Ne retrievals are in good agreement with the IRI (International Reference Ionosphere) model in terms of monthly maps, zonal means and diurnal variations. The daytime GPS-RO Ne profiles can be well characterized by the α-Chapman function of three parameters (NmE, hmE and H), showing that the bottom of E-region is deepening and sharpening towards the summer pole. At high latitudes the monthly GPS-RO Ne maps at 80-120 km reveal clear enhancement in the auroral zones, more prominent at night, as a result of energetic electron precipitation (EEP) from the outer radiation belt. The D-/E-region auroral Ne is strongly correlated with Kp on a daily basis. The new Ne data allow further comprehensive analyses of the sporadic E (Es) phenomena in connection with the background Ne in the E-region. The layered (2-10 km) and fluctuated (Layer than Ne_Pert, are extracted with respect to the background Ne_Region on a profile-by-profile basis. The Ne_Layer component has a strong but highly-refined peak at ∼105 km, with an amplitude smaller than Ne_Region approximately by an order of magnitude. The Ne_Pert component, which was studied extensively in the past, is ∼2 orders of magnitude weaker than Ne_Layer. Both Ne_Layer and Ne_Pert are subject to significant diurnal and semidiurnal variations, showing downward progression with local time in amplitude. The 11-year solar cycle dominates the Ne interannual variations, showing larger Ne_Region and Ne_Layer but smaller

The flotation of Roşia Poieni copper ore in column machine, with non-polar oils addition

Directory of Open Access Journals (Sweden)

Ciocani V.

2005-11-01

Full Text Available The most important natural resource of copper in Romania is the ore deposit of Roşia Poieni. At present, the utilization of Roşia Poieni poorphyry copper ore is possible by extraction in quarry of the mass ore and mineral processing into a technological flux with modest results for the value of metal recovery in concentrate 70-72 % and an average contents of 16,5 % Cu. Our researches were directed to studies regarding test and utilisation of special procedure of flotation – addition of the non-polar oil – applied to advanced grinding ore with column type machines.

Anti-Ro and anti-La autoantibodies induce TNF-α production by human salivary gland cells: an in vitro study

Directory of Open Access Journals (Sweden)

V. Mitolo

2011-09-01

Full Text Available Obiettivo: Lo scopo di questo studio è stato valutare la produzione di TNF-α, induttore della via estrinseca del processo apoptotico, in seguito al trattamento con gli autoanticorpi anti-Ro ed anti-La isolati da pazienti con sindrome di Sjögren primaria in un modello sperimentale rappresentato dalla linea cellulare di ghiandole salivari umane, A- 253. È stata, inoltre, valutata la presenza sulla superficie di tali cellule di recettori specifici per tale induttore, TNFR1 e TNFR2. Materiali e metodi: Gli autoanticorpi anti-La ed anti-Ro sono stati purificati su una colonna cromatografia ad alta affinità. Le metodiche utilizzate per la valutazione della produzione di TNF-α e lo studio dei recettori di superficie sono state immunofluorescenza, RT-PCR e saggi immunoenzimatici. Risultati: I nostri risultati hanno dimostrato che le cellule A-253 esprimono in superficie i recettori TNFR1 e TNFR2 e che gli autoanticorpi anti-Ro e anti-La sono in grado di indurre la produzione di TNF-α nelle stesse cellule. Conclusioni: Il trattamento con gli autoanticorpi anti-Ro ed anti-La induce la produzione di TNF-α in cellule di ghiandole salivari umane e questo potrebbe spiegare la attivazione della via estrinseca della apoptosi.

Health, Sanitary and Economic Evaluation of Home-like Systems of Water Treatment (Reverse Osmosis, RO in Qom City

Directory of Open Access Journals (Sweden)

Mohammadreza Jafaripour

2011-07-01

Full Text Available Reverse Osmosis (RO is one of the most useful techniques to improve the elimination of organic and mineral Substances from ground and surface water after primary purification processes such as coagulation, sedimentation and filtration.This System provides the required water quality characteristics to somehow.  However, in selection RO systems civil management decision and general public opinion along with cost and health impact must be considered. This study was done in 2010. Statistical methods have used to gather data about of families who used RO In their private homes and mode of eliminate of the wastewater generated by this process. The results indicated that in the normal operational conditions such as pressure 6- 10 kg / cm2 the, optimum recovery % 30 and flow rate 1lit/min , and water temperature 4- 38C°, an Amount of 14191200 kwh of power energy have been consumed to produce 157680 m3 / year treated water required for 36000 families. This has also generated 367920 m3 / year of wastewater being disposed without any management and environmental considerations. Apart from that more than 198000 of filters have been ejected to the environment. Also regarding health aspects, reducing the hardness and fluoride levels in treated water could be undesirable. It could be concluded that increasing the number of local water distribution points and speeding up the water supplying project from Dez river toQom can decrease the investment on RO system.

Transient behaviour and coupling aspects of a hybrid MSF-RO nuclear desalination plant

International Nuclear Information System (INIS)

Tewari, P.K.; Misra, B.M.

1998-01-01

BARC is setting up a 6300 M 3 /day (1.4 MGD) hybrid MSF-RO nuclear desalination plant for sea water desalination at Madras Atomic Power Station (MAPS) coupled to a 170 MWe Pressurised Heavy Water Reactor (PHWR). The transient behaviour and coupling aspects of this dual purpose plant has been discussed. A hybrid desalination plant appears to offer high availability factor. (author)

The Modified Fouling Index Ultrafiltration constant flux for assessing particulate/colloidal fouling of RO systems

KAUST Repository

Salinas-Rodriguez, Sergio G.; Amy, Gary L.; Schippers, Jan C.; Kennedy, Maria D.

2015-01-01

that remain on the surface of membrane) were measured in a full-scale plant ranging between 0.2 and 0.5. The concept of “safe MFI” is presented as a guideline for assessing pre-treatment for RO systems.

Changes of seizure susceptibility during benzodiazepine withdrawal in immature rats: comparison of clonazepam and partial benzodiazepine agonist Ro 19-8022

Czech Academy of Sciences Publication Activity Database

Kubová, Hana

2006-01-01

Roč. 47, č. S4 (2006), s. 221-221 ISSN 0013-9580. [Annual Meeting of the American Epilepsy Society and Canadian League against Epilepsy. 01.12.2006-05.12.2006, San Diego, CA] R&D Projects: GA MŠk(CZ) LC554 Institutional research plan: CEZ:AV0Z50110509 Keywords : PTZ-induced seizures * clonazepam * agonist Ro 19-8022 Subject RIV: ED - Physiology

Yaacov Ro´i, Boris Morozov, eds, The Soviet Union and the June 1967 Six Day War

OpenAIRE

Rey, Marie-Pierre

2009-01-01

L’ouvrage coordonné par Yaacov Ro´i et Boris Morozov réunit neuf contributions qui, émanant de chercheurs américains, russes et israéliens et toutes fondées sur des archives depuis peu accessibles, éclaire de manière nouvelle et convaincante la question de l’engagement et du rôle de l’Union soviétique durant la guerre des Six Jours. Cinq articles présentés dans le volume traitent directement de l’attitude soviétique à l’heure du conflit. Le premier, rédigé par Yaacov Ro´i, traite de l’engagem...

State of the art of the production and utilization of biogas using the NawaRo plant; Stand der Technik bei der Erzeugung und Nutzung von Biogas unter Einsatz von NawaRo-Anlagen

Energy Technology Data Exchange (ETDEWEB)

Weiland, P.; Rieger, C.; Schroeder, J. [Bundesforschungsanstalt fuer Landwirtschaft (FAL), Braunschweig (Germany); Kissel, R.; Bachmaier, H. [LfL, Freising (Germany); Plogsties, V. [ATB, Potsdam (Germany); Vogtherr, J. [Hohenheim Univ., Stuttgart (Germany)

2007-07-01

With amending the Renewable Energy Law (EEG) in August 2004 the fundamentals for the utilization of renewable raw materials in biological gas facilities were created. Since that time the number of installed plants processing energy plants grew very fast, although at the time of amending only few experiences with NawaRo plants were present. Therefore, in order to attain secured informations about the current state of the art in the production and utilization of fermentation gas to, in the context of a country wide measuring program, NawaRo plants are examined and evaluated according to technical and economic criteria. The results determined so far show that due to the intensified employment by energy plants completely new dosing systems and agitating systems are applied, and also pure fermentation techniques for solids increasingly are used for the mono fermentation of renewable raw materials. Although the common generation of current and heat in cogeneration plants dominate, new use routes like the feed of bio methane in the natural gas grid as well as the utilization of the gas as fuel gain in importance.

ÜRO rahuvalvajatel lasub taas laste ahistamise süüdistus / Oliver Tiks, Hendrik Vosman

Index Scriptorium Estoniae

Tiks, Oliver

2008-01-01

Ilmunud ka: Postimees : na russkom jazõke 28. mai 2008, lk. 5. Briti heategevusorganisatsiooni Save the Children raport avalikustas, et maailma kriisipiirkondades on lapsed sattunud neid turvama saadetud ÜRO rahuvalvajate ja abitöötajate seksuaalse kuritarvitamise ohvriks. Lisa: Seksiskandaalid

Differential effect of detergents on [3H]Ro 5-4864 and [3H]PK 11195 binding to peripheral-type benzodiazepine-binding sites

International Nuclear Information System (INIS)

Awad, M.; Gavish, M.

1988-01-01

The present study demonstrates a differential effect of various detergent treatments on [ 3 H]Ro 5-4864 and [ 3 H]PK 11195 binding to peripheral benzodiazepine binding sites (PBS). Triton X-100 caused a decrease of about 70% in [ 3 H]Ro 5-4864 binding to membranes from various peripheral tissues of rat, but had only a negligible effect on [ 3 H]PK 11195 binding. A similar effect of Triton X-100 was observed on guinea pig and rabbit kidney membranes. The decrease in [ 3 H]Ro 5-4864 binding after treatment with Triton X-100 was apparently due to a decrease in the density of PBS, since the affinity remained unaltered. The detergents 3-[(3-cholamidopropyl)-dimethylammonio]-1-propane sulfonate (CHAPS), Tween 20, deoxycholic acid, or digitonin (0.0125%) caused only a minor change in [ 3 H]Ro 5-4864 and [ 3 H]PK 11195 binding to rat kidney membranes; but when concentrations were substantially increased (0.1%), all detergents caused a decrease of at least 50% in [ 3 H]Ro 5-4864 binding, while [ 3 H]PK 11195 binding to rat kidney membranes remained unaffected by the first three detergents, with only a minor decrease (15%) after treatment with digitonin

Influence of B-Complex Vitamins on the Pharmacokinetics of Ginsenosides Rg1, Rb1, and Ro After Oral Administration.

Science.gov (United States)

Zheng, Peihe; Chen, Yinbin; Fu, Yangyang; Wang, Hecheng; Wang, Jia; Zheng, Siwen; Xiao, Shengyuan; Wang, Yingping

2017-11-01

After cultivation of ginseng, ginsenosides, which are the major active ingredients of gingeng, were approved for use by the food industry, and began to be used as added functional ingredients to try to improve the quality and price of functional foods. However, the interaction between different types of ginsenosides and nutrients needs further study. We investigated the effect of B-complex vitamins (which are essential nutrients) on the pharmacokinetics of the ginsenosides protopanaxatriol-type saponin Rg 1 , protopanaxadiol-type saponin Rb 1 , and oleanolic acid-type saponin Ro after oral administration. Ginsenosides Rg 1 , Rb 1 , and Ro, with or without B-complex vitamins, respectively, were administered orally to rats to evaluate their pharmacokinetics. The concentration of ginsenosides in plasma was determined by liquid chromatography/tandem mass spectrometry. Pharmacokinetic parameters were fitted using WinNonlin v6.2. After oral coadministration with B-complex vitamins, the area under the concentration-time curve from zero to infinity (AUC 0-∞ ) of ginsenoside Rg 1 was reduced by 70%, that of ginsenoside Rb 1 was reduced by 43%, and that of ginsenoside Ro was reduced by 34%. The AUC 0-∞ of ginsenosides Rg 1 and Rb 1 showed significant differences between different treatments, but the AUC 0-∞ of ginsenoside Ro did not. These results suggest significant ginsenoside-nutrient interactions between ginsenosides Rg 1 , Rb 1 , and B-complex vitamins.

Biodegradation of Azo Dye RO16 in Different Reactors by Immobilized Irpex lacteus

Czech Academy of Sciences Publication Activity Database

Tavčar, M.; Svobodová, Kateřina; Kuplenk, J.; Novotný, Čeněk; Pavko, A.

2006-01-01

Roč. 53, - (2006), s. 338-343 ISSN 1318-0207 R&D Projects: GA MŠk(CZ) 1P05ME828; GA AV ČR(CZ) IAA6020411; GA ČR(CZ) GP526/06/P102 Institutional research plan: CEZ:AV0Z50200510 Keywords : irpex lacteus * dye decolorization * trickle bed reactor Subject RIV: EE - Microbiology, Virology Impact factor: 0.703, year: 2006

Stavovi medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene novorođenčadi

OpenAIRE

Bilić, Iva; Prpić, Igor; Radić, Jelena; Vukelić, Petar; Petrović, Ana; Juretić, Emilija; Furlan, Ivanka

2008-01-01

CILJ: Cilj istraživanja bilo je ispitati stavove medicinskih sestara u Hrvatskoj o primarnom oživljavanju prijevremeno rođene djece. METODE: Pisanom anketom ispitivana je dob, roditeljstvo, radno iskustvo i mjesto rada te stavovi medicinskih sestara iz Hrvatske o primarnom oživljavanju prijevremeno rođene djece. Anketirano je 174 medicinskih sestara; 49 zaposlenih u rađaonici ili na mjestima rada sa trudnicama (Rađ/Tr), 79 u pedijatrijskim/ neonatološkim jedinicama intenzivnog liječenja (...

The antimalarial drug, Ro 42-1611 (arteflene), does not affect cytoadherence and cytokine-inducing properties of Plasmodium falciparum malaria parasites

DEFF Research Database (Denmark)

Jakobsen, P H; Staalsø, T; Bendtzen, K

1995-01-01

The purpose of this study was to investigate the ability of the antimalarial drug, Ro 42-1611 to block parasite mediated cytokine induction in vitro as well as cytoadherence of infected erythrocytes to melanoma cells in vitro. The biological activity of Ro 42-1611 was confirmed as it blocked...... to melanoma cells. The therapeutic effect of To 42-1611 appears to be confined to its parasite killing activity....

Dvě výročí Ronalda Richtra – rodáka ze Sokolova

Czech Academy of Sciences Publication Activity Database

Řípa, Milan

2011-01-01

Roč. 59, č. 23 (2011), s. 28-28 ISSN 0040-1064 Institutional research plan: CEZ:AV0Z20430508 Keywords : fusion * Huemul Project * Juan Peron * Matterhorn * Dmitrij Sacharov * Jevgenij Tamm * Lyman Spitzer * Ronald Richter Subject RIV: BL - Plasma and Gas Discharge Physics

Výročí narození zakladatele brněnské balkanistiky prof. dr. Josefa Kabrdy

Czech Academy of Sciences Publication Activity Database

Hladký, Ladislav

2016-01-01

Roč. 102, č. 1 (2016), s. 159-161 ISSN 0037-6922 Institutional support: RVO:67985963 Keywords : Historian Josef Kabrda (1906–1968) * Balkan studies, history of Ottoman Empire Subject RIV: AB - History

3D visualization of the internal nanostructure of polyamide thin films in RO membranes

KAUST Repository

Pacheco Oreamuno, Federico

2015-11-02

The front and back surfaces of fully aromatic polyamide thin films isolated from reverse osmosis (RO) membranes were characterized by TEM, SEM and AFM. The front surfaces were relatively rough showing polyamide protuberances of different sizes and shapes; the back surfaces were all consistently smoother with very similar granular textures formed by polyamide nodules of 20–50 nm. Occasional pore openings of approximately the same size as the nodules were observed on the back surfaces. Because traditional microscopic imaging techniques provide limited information about the internal morphology of the thin films, TEM tomography was used to create detailed 3D visualizations that allowed the examination of any section of the thin film volume. These tomograms confirmed the existence of numerous voids within the thin films and revealed structural characteristics that support the water permeance difference between brackish water (BWRO) and seawater (SWRO) RO membranes. Consistent with a higher water permeance, the thin film of the BWRO membrane ESPA3 contained relatively more voids and thinner sections of polyamide than the SWRO membrane SWC3. According to the tomograms, most voids originate near the back surface and many extend all the way to the front surface shaping the polyamide protuberances. Although it is possible for the internal voids to be connected to the outside through the pore openings on the back surface, it was verified that some of these voids comprise nanobubbles that are completely encapsulated by polyamide. TEM tomography is a powerful technique for investigating the internal nanostructure of polyamide thin films. A comprehensive knowledge of the nanostructural distribution of voids and polyamide sections within the thin film may lead to a better understanding of mass transport and rejection mechanisms in RO membranes.

3D visualization of the internal nanostructure of polyamide thin films in RO membranes

KAUST Repository

Pacheco Oreamuno, Federico; Sougrat, Rachid; Reinhard, Martin; Leckie, James O.; Pinnau, Ingo

2015-01-01

The front and back surfaces of fully aromatic polyamide thin films isolated from reverse osmosis (RO) membranes were characterized by TEM, SEM and AFM. The front surfaces were relatively rough showing polyamide protuberances of different sizes and shapes; the back surfaces were all consistently smoother with very similar granular textures formed by polyamide nodules of 20–50 nm. Occasional pore openings of approximately the same size as the nodules were observed on the back surfaces. Because traditional microscopic imaging techniques provide limited information about the internal morphology of the thin films, TEM tomography was used to create detailed 3D visualizations that allowed the examination of any section of the thin film volume. These tomograms confirmed the existence of numerous voids within the thin films and revealed structural characteristics that support the water permeance difference between brackish water (BWRO) and seawater (SWRO) RO membranes. Consistent with a higher water permeance, the thin film of the BWRO membrane ESPA3 contained relatively more voids and thinner sections of polyamide than the SWRO membrane SWC3. According to the tomograms, most voids originate near the back surface and many extend all the way to the front surface shaping the polyamide protuberances. Although it is possible for the internal voids to be connected to the outside through the pore openings on the back surface, it was verified that some of these voids comprise nanobubbles that are completely encapsulated by polyamide. TEM tomography is a powerful technique for investigating the internal nanostructure of polyamide thin films. A comprehensive knowledge of the nanostructural distribution of voids and polyamide sections within the thin film may lead to a better understanding of mass transport and rejection mechanisms in RO membranes.

Fresh water production from municipal waste water with RO membrane technology and its application for agriculture and industry in arid area

International Nuclear Information System (INIS)

Yokoyama, F

2015-01-01

One of the biggest problems of the 21st century is the global water shortage. Therefore it is difficult to increase the quantity of conventional water resources such as surface water and groundwater for agriculture and industry in arid area. Technical advancement in water treatment membrane technology including RO membrane has been remarkable especially in recent years. As the pore size of RO membrane is less than one nanometer, it is possible to produce the fresh water, which satisfies the drinking water quality standards, with utilizing RO membrane. In this report a new fresh water resource from municipal waste water is studied to apply to the plant factory which is the water saving type agriculture and industry in arid area

Application of monochloramine for wastewater reuse: Effect on biostability during transport and biofouling in RO membranes

KAUST Repository

Siddiqui, Amber; Loubineaud, E.; Prest, E.I.E.C.; El Chakhtoura, Joline; Salles, C.; Bucs, Szilard; Trampé , J.; Van den Broek, W.B.P.; Van Agtmaal, J.M.C.; Van Loosdrecht, M.C.M.; Kruithof, J.C.; Vrouwenvelder, Johannes S.

2018-01-01

The rising demand for clean and safe water has increased the interest in advanced wastewater treatment and reuse. Reverse osmosis (RO) can provide reliable and high-quality water from treated wastewater. Biofouling inevitably occurs, certainly

Zamyšlení nad publikací Ročenka konkurenceschopnosti České republiky 2005

Czech Academy of Sciences Publication Activity Database

Lízal, Lubomír

2006-01-01

Roč. 54, č. 4 (2006), s. 549-556 ISSN 0032-3233 Institutional research plan: CEZ:AV0Z70850503 Keywords : competitive ness * Czech Republic Subject RIV: AH - Economics Impact factor: 0.363, year: 2006

Akademický portál CoolCite

Czech Academy of Sciences Publication Activity Database

Skovajsa, Marek

2010-01-01

Roč. 11, č. 4 (2010), s. 18 ISSN 1210-9525. [Akademický portál CoolCite. Prezentace a diskuse. Praha, 01.02.2010] Institutional research plan: CEZ:AV0Z70280505 Keywords : scientometrics * academic performance measurement * academic portals Subject RIV: AO - Sociology, Demography

Biodistribution and metabolism of the anti-influenza drug [{sup 11}C]oseltamivir and its active metabolite [{sup 11}C]Ro 64-0802 in mice

Energy Technology Data Exchange (ETDEWEB)

Hatori, Akiko; Arai, Takuya; Yanamoto, Kazuhiko; Yamasaki, Tomoteru; Kawamura, Kazunori; Yui, Joji; Konno, Fujiko; Nakao, Ryuji; Suzuki, Kazutoshi [Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555 (Japan); Zhang Mingrong [Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences (NIRS), Inage-ku, Chiba 263-8555 (Japan)], E-mail: zhang@nirs.go.jp

2009-01-15

Introduction: Oseltamivir phosphate (Tamiflu) is an orally active anti-influenza drug, which is hydrolyzed by esterase to its carboxylate metabolite Ro 64-0802 with potent activity to inhibit the influenza virus. The abnormal behavior and death associated with the use of oseltamivir have developed into a major problem in Japan where Tamiflu is often prescribed for seasonal influenza. It is critical to determine the amount of oseltamivir and Ro 64-0802 in the human brain and to elucidate the relationship between their amounts and neuropsychiatric side effects. The aim of this study was to evaluate [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in mice as promising positron emission tomography (PET) ligands for measuring their amounts in living brains. Methods: Whole-body biodistribution of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 was determined in mice using the dissection method and micro-PET. In vitro and in vivo metabolite assay was performed in the plasma and brain of mice. Results: Between 1 and 60 min after injection of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802, 0.20-0.06% and 0.39-0.03% ID/g were detected in the mouse brains, respectively (dissection method). Radioactivity concentrations in the living brains between 0 and 90 min after injection were measured at standardized uptake values of 0.25-0.05 for [{sup 11}C]oseltamivir and 0.38-0.02 for [{sup 11}C]Ro 64-0802 (micro-PET). In vivo metabolite assay demonstrated the presence of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in the brains after [{sup 11}C]oseltamivir injection. Conclusion: This study determined the distribution and metabolism of [{sup 11}C]oseltamivir and [{sup 11}C]Ro 64-0802 in mice. PET could be used to measure their amounts in the living brain and to elucidate the relationship between the amounts in the brain and the side effects of Tamiflu in the central nervous system.

Regional specific binding of [11C]RO 15 1788 to central type benzodiazepine receptors in human brain: quantitative evaluation by PET

International Nuclear Information System (INIS)

Pappata, S.; Samson, Y.; Chavoix, C.; Prenant, C.; Maziere, M.; Baron, J.C.

1988-01-01

The central type benzodiazepine receptors were studied in 17 healthy human subjects with 11 C-RO 15 1788 and positron emission tomography (PET). The brain regional distribution of the tracer in eight control studies performed after injection of trace doses of 11 C-RO 15 1788 was consistent with that of benzodiazepine receptors. Saturation studies with co-injected cold RO 15 1788 in the remaining subjects showed a dose-dependent decrease of brain radiotracer until full inhibition of specific binding was achieved with doses above 0.1 mg/kg (four studies). Based on the results, a simple method to estimate the specifically bound 11 C-RO 15 1788 regionally in a single PET study is proposed, using the data from the full-saturation studies as a stable estimate of the nondisplaceable radioligand concentration. Using this method, it was found that quasiequilibrium between the estimated specifically bound and nondisplaceable components was achieved at times equal to or longer than 20 min after tracer administration. The validity of this method was partly supported by further results, showing a good agreement between the regional specific binding so calculated and postmortem data of receptor density

ÜRO süüdistab USA-d piinamises ja nõuab Guantanamo laagri sulgemist / Krister Paris

Index Scriptorium Estoniae

Paris, Krister, 1977-

2006-01-01

ÜRO inimõiguste komisjoni esindajad uurisid Guantanamo vanglast vabanenutelt, nende advokaatidelt ja arstidelt vangide kohtlemist Guantanamos. Uurimise raportist. Lisa: Vanglat aitavad täita pearahakütid

Rebound increase in seizure susceptibility but not isolation-induced calls after single administration of clonazepam and Ro 19-8022 in infant rats

Czech Academy of Sciences Publication Activity Database

Mikulecká, Anna; Mareš, Pavel; Kubová, Hana

2011-01-01

Roč. 20, č. 1 (2011), s. 12-19 ISSN 1525-5050 R&D Projects: GA ČR(CZ) GA305/09/0846 Institutional research plan: CEZ:AV0Z50110509 Keywords : Pentylenetetrazole-induced seizure * ultrasonic vocalization * motor performance * Clonazepam * Ro 19-8022 * immature rats Subject RIV: FH - Neurology Impact factor: 2.335, year: 2011

Observations of gas- and aerosol-phase organic nitrates at BEACHON-RoMBAS 2011

Directory of Open Access Journals (Sweden)

J. L. Fry

2013-09-01

Full Text Available At the Rocky Mountain Biogenic Aerosol Study (BEACHON-RoMBAS field campaign in the Colorado front range, July–August 2011, measurements of gas- and aerosol-phase organic nitrates enabled a study of the role of NOx (NOx = NO + NO2 in oxidation of forest-emitted volatile organic compounds (VOCs and subsequent aerosol formation. Substantial formation of peroxy- and alkyl-nitrates is observed every morning, with an apparent 2.9% yield of alkyl nitrates from daytime RO2 + NO reactions. Aerosol-phase organic nitrates, however, peak in concentration during the night, with concentrations up to 140 ppt as measured by both optical spectroscopic and mass spectrometric instruments. The diurnal cycle in aerosol fraction of organic nitrates shows an equilibrium-like response to the diurnal temperature cycle, suggesting some reversible absorptive partitioning, but the full dynamic range cannot be reproduced by thermodynamic repartitioning alone. Nighttime aerosol organic nitrate is observed to be positively correlated with [NO2] × [O3] but not with [O3]. These observations support the role of nighttime NO3-initiated oxidation of monoterpenes as a significant source of nighttime aerosol. Nighttime production of organic nitrates is comparable in magnitude to daytime photochemical production at this site, which we postulate to be representative of the Colorado front range forests.

YSOVAR II: Mapping YSO Inner Disk Structure in NGC 2264 with Simultaneous Spitzer and CoRoT Time Series Photometry

Science.gov (United States)

Stauffer, John; Morales-Calderon, Maria; Rebull, Luisa; Affer, Laura; Alencar, Sylvia; Allen, Lori; Barrado, David; Bouvier, Jerome; Calvet, Nuria; Carey, Sean; Carpenter, John; Ciardi, David; Covey, Kevin; D'Alessio, Paola; Espaillat, Catherine; Favata, Fabio; Flaccomio, Ettore; Forbrich, Jan; Furesz, Gabor; Hartman, Lee; Herbst, William; Hillenbrand, Lynne; Holtzman, Jon; Hora, Joe; Marchis, Franck; McCaughrean, Mark; Micela, Giusi; Mundt, Reinhard; Plavchan, Peter; Turner, Neal; Skrutzkie, Mike; Smith, Howard; Song, Inseok; Szentgyorgi, Andy; Terebey, Susan; Vrba, Fred; Wasserman, Lawrence; Watson, Alan; Whitney, Barbara; Winston, Elaine; Wood, Kenny

2011-05-01

We propose a simultaneous, continuous 30 day observation of the star forming region NGC2264 with Spitzer and CoRoT. NGC2264 is the only nearby, rich star-forming region which can be observed with CoRoT; it is by definition then the only nearby, rich star-forming region where a simultaneous Spitzer/CoRoT campaign is possible. Fortunately, the visibility windows for the two spacecraft overlap, allowing this program to be done in the Nov. 25, 2011 to Jan. 4, 2012 time period. For 10 days, we propose to map the majority of the cluster (a 35'x35' region) to a depth of 48 seconds per point, with each epoch taking 1.7 hours, allowing of order 12 epochs per day. For the other 20 days, we propose to obtaining staring-mode data for two positions in the cluster having a high density of cluster members. We also plan to propose for a variety of other ground and space-based data, most of which would also be simultaneous with the Spitzer and CoRoT observing. These data will allow us to address many astrophysical questions related to the structure and evolution of the disks of young stars and the interaction of those disks with the forming star. The data may also help inform models of planet formation since planets form and migrate through the pre-main sequence disks during the 0.5-5 Myr age range of stars in NGC2264. The data we collect will also provide an archive of the variability properties of young stars that is unmatched in its accuracy, sensitivity, cadence and duration and which therefore could inspire investigation of phenomena which we cannot now imagine. The CoRoT observations have been approved, contingent on approval of a simultaneous Spitzer observing program (this proposal).

Několik poznámek k výročí 20 let od rozsudku Bosman

Czech Academy of Sciences Publication Activity Database

Hamerník, Pavel

2015-01-01

Roč. 5, č. 3 (2015), s. 26-30 ISSN 1338-5569 Institutional support: RVO:68378122 Keywords : EU Law * transfer fee * football Subject RIV: AG - Legal Sciences http://www.magisterofficiorum.sk/vydania-rocnik-v-2015/cislo-3-2015/

Pohled do Wundtovy laboratoře - 130. výročí založení

Czech Academy of Sciences Publication Activity Database

Vobořil, Dalibor; Květon, Petr; Jelínek, Martin

2009-01-01

Roč. 53, č. 6 (2009), s. 645-651 ISSN 0009-062X Institutional research plan: CEZ:AV0Z70250504 Keywords : history of psychology * laboratory * W. Wundt Subject RIV: AN - Psychology Impact factor: 0.226, year: 2009

Persistent fetal sinus bradycardia associated with maternal anti-SSA/Ro and anti-SSB/La antibodies

NARCIS (Netherlands)

Chockalingam, Priya; Jaeggi, Edgar T.; Rammeloo, Lukas A.; Haak, Monique C.; Adama van Scheltema, Phebe N.; Breur, Johannes M. P. J.; Bartelings, Margot M.; Clur, Sally-Ann B.; Blom, Nico A.

2011-01-01

To study the clinical course and outcome of fetal sinus bradycardia (SB) due to maternal antibody-induced sinus node dysfunction. We reviewed the maternal, prenatal, and postnatal findings of fetuses with SB associated with elevated maternal anti-SSA/Ro and anti-SSB/La antibodies. Of the 6 cases

Triumfalnoje vozvrashtshenije 60-h / Airika Soome, Jaanika Sootna, Merike Pääro...[jt.] ; interv. Valeria Aru

Index Scriptorium Estoniae

2007-01-01

Eesti tuntuimate kaubamärkide PTA, Monton, Bastion, Ivo Nikkolo ja Mosaic moekunstnike nägemused moest kevad-suveks 2007. PTA - Airika Soome, Monton - Jaanika Sootna, Bastion - Merike Pääro, Ivo Nikkolo - Eve Hanson ja Mosaic - Evelin Lill

Effective Design for Optical CDMA Based on Radio over Fiber (RoF Technique

Directory of Open Access Journals (Sweden)

Rashidi C. B. M.

2017-01-01

Full Text Available In this paper, the performance of OCDMA coding systems utilizing the radio over fiber (RoF technique is presented. It has been done by means of conventional OptiSystem simulation tools, where the propagation of radio signals up to 50 km using standard single mode fiber (SMF was investigated. The analysis was made based on the performance of eye diagram, bit rate, bit error rate and optical received power.

Photoaffinity labeling of [3H]flunitrazepam- and [3H]Ro15-4513-bound pellets in rat cerebral cortex and cerebellum

International Nuclear Information System (INIS)

Chiu, T.H.; Yu, Onnfoh; Rosenberg, H.C.

1989-01-01

Irreversible incorporation of [ 3 H]flunitrazepam and [ 3 H]Ro15-4513 into GABA/benzodiazepine receptor subunits was studied by UV/irradiation using ligand-bound membrane pellets from rat cerebral cortical and cerebellar synaptic membranes. Specific incorporation for [ 3 H]flunitrazepam was greater in the pellet than in the suspension. The incorporation was identical for [ 3 H]Ro15-4513 in both pellet and suspension. With the ligand-bound pellets, 50% of the available binding sites were photolabeled by both ligands in cortex and cerebellum. SDS polyacrylamide gel electrophoresis and fluorography of [ 3 H]flunitrazepam photo-labeled receptor revealed the same number of major sites in both brain regions. In contrast, [ 3 H]Ro15-4513 appears to label fewer sites in cortex and cerebellum. Photoaffinity labeling with [ 3 H]flunitrazepam in ligand-bound membrane pellet provides a more selective and reliable method for studying the subunit structure of GABA/benzodiazepine receptor complex

Staurosporine, but not Ro 31-8220, induces interleukin 2 production and synergizes with interleukin 1alpha in EL4 thymoma cells.

Science.gov (United States)

Mahon, T M; Matthews, J S; O'Neill, L A

1997-07-01

Protein kinase C (PKC) has been implicated in interleukin 1 (IL1) signal transduction in a number of cellular systems, either as a key event in IL1 action or as a negative regulator. Here we have examined the effects of two PKC inhibitors, staurosporine and the more selective agent Ro 31-8220, on IL1 responses in the murine thymoma line EL4.NOB-1. A 1 h pulse of staurosporine was found to strongly potentiate the induction of IL2 by IL1alpha in these cells. In contrast, neither a pulse nor prolonged incubation with Ro 31-8220 affected the response to IL1alpha. Both agents blocked the response to PMA, however. A 1 h pulse of staurosporine was also found to induce IL2 production on its own, activate the transcription factor nuclear factor kappaB (NFkappaB) and increase the expression of a NFkappaB-linked reporter gene. It synergized with IL1alpha in all of these responses. Ro 31-8220 was again without effect, although both staurosporine and Ro 31-8220 blocked the activation of NFkappaB by PMA. Finally, staurosporine caused the translocation of PKC-alpha and -epsilon, and to a lesser extent PKC-beta, but not PKC-θ or -zeta, from the cytosol to the membrane, although a similar effect was observed with Ro 31-8220. The results suggest that PKC is not involved in IL1alpha signalling in EL4 cells. Furthermore, the potentiating effect of staurosporine on IL1alpha action does not involve PKC inhibition, and is likely to be at the level of NFkappaB activation.

3D morphological characterization of the polyamide active layer of RO and NF membranes using TEM and soft X-ray scattering

Science.gov (United States)

Culp, Tyler; Paul, Mou; Roy, Abhishek; Rosenberg, Steve; Behr, Michael; Kumar, Manish; Gomez, Enrique; Penn State Team; Dow Team

Polyamide-based thin-film composite (TFC) membranes used for reverse osmosis (RO) and nanofiltration (NF) separation processes are at the forefront of water desalination and purification technologies due to their high salt rejection, high energy efficiency, and ease of operation. Nevertheless, in spite of the benefits of RO and NF membranes, many open questions about the internal nanostructure of the membrane active layer remain, such as the dispersion and distribution of acid functional groups. We demonstrate that resonant soft X-ray scattering (RSOXS), where the X-ray energy is tuned to absorption edges of the constituent materials, is a powerful tool to examine the microstructure of the polyamide layer. In conjunction with complementary techniques such as transmission electron microscopy (TEM), where tomography is used to obtain a 3D reconstruction of the polyamide active layer, the effect of cross-linking can be quantified in 3D for a systematic series of membranes. This relationship can then be applied to a series of commercially available RO and NF membranes where the effect of polyamide cross-linking on their respective structure and water transport properties can be evaluated. The combination of RSOXS with traditional characterization tools provides a strategy for linking the chemical structure to the morphology and water transport properties of RO and NF membranes.

CoRoT-2b: a Tidally Inflated, Young Exoplanet?

Science.gov (United States)

Guillot, Tristan; Havel, M.

2009-09-01

CoRoT-2b is among the most anomalously large transiting exoplanet known. Due to its large mass (3.3 Mjup), its large radius ( 1.5 Rjup) cannot be explained by standard evolution models. Recipes that work for other anomalously large exoplanets (e.g. HD209458b), such as invoking kinetic energy transport in the planetary interior or increased opacities, clearly fail for CoRoT-2b. Interestingly, the planet's parent star is an active star with a large fraction (7 to 20%) of spots and a rapid rotation (4.5 days). We first model the star's evolution to accurately constrain the planetary parameters. We find that the stellar activity has little influence on the star's evolution and inferred parameters. However, stellar evolution models point towards two kind of solutions for the star-planet system: (i) a very young system (20-40 Ma) with a star still undergoing pre-main sequence contraction, and a planet which could have a radius as low as 1.4 Rjup, or (ii) a young main-sequence star (40 to 500 Ma) with a planet that is slightly more inflated ( 1.5 Rjup). In either case, planetary evolution models require a significant added internal energy to explain the inferred planet size: from a minimum of 3x1028 erg/s in case (i), to up to 1.5x1029 erg/s in case (ii). We find that evolution models consistently including planet/star tides are able to reproduce the inferred radius but only for a short period of time ( 10 Ma). This points towards a young age for the star/planet system and dissipation by tides due to either circularization or synchronization of the planet. Additional observations of the star (infrared excess due to disk?) and of the planet (precise Rossiter effect, IR secondary eclispe) would be highly valuable to understand the early evolution of star-exoplanet systems.

Marine bacterial transparent exopolymer particles (TEP) and TEP precursors: Characterization and RO fouling potential

KAUST Repository

Li, Sheng

2015-10-31

This paper investigated the characteristics and membrane fouling potential of bacterial transparent exopolymer particles (TEP)/TEP precursors released from two marine bacteria, Pseudidiomarina homiensis (P. homiensis) and Pseudoalteromonas atlantica (P. atlantica), isolated from the Red Sea. Results showed that both bacteria grew at the similar rate, but the production of TEP/TEP precursors from P. atlantica was higher than that from P. homiensis. During the 168. h of incubation time, production rates of TEP/TEP precursors from P. atlantica and P. homiensis were 0.30 and 0.08 xanthan gum eq. mg/L-h, respectively. Isolated bacterial TEP precursors were mainly biopolymer, and P. atlantica produced a significantly higher concentration of biopolymer than that produced by P. homiensis. TEP/TEP precursors from both marine bacteria possessed protein-like material and were very similar in composition to previously reported foulants isolated from a fouled reverse osmosis (RO) membrane. Bacterial TEP/TEP precursors mostly consisted of aliphatic hydrocarbon from amino acids and amide group carbon of proteins (around 55%). Bacterial TEP precursors caused obvious fouling on RO membranes, which may create an ideal environment for bacteria attachment and promote to biofouling.

Transiting exoplanets from the CoRoT space mission. XXIII. CoRoT-21b: a doomed large Jupiter around a faint subgiant star

DEFF Research Database (Denmark)

Pätzold, M.; Endl, M.; Csizmadia, Sz.

2012-01-01

-up observations, however, were performed mainly by the 10-m Keck telescope in January 2010. The companion CoRoT-21b is a Jupiter-like planet of 2.26 ± 0.33 Jupiter masses and 1.30 ± 0.14 Jupiter radii in an circular orbit of semi-major axis 0.0417 ± 0.0011 AU and an orbital period of 2.72474 ± 0.00014 days....... The planetary bulk density is (1.36   ±   0.48) × 103 kg m-3, very similar to the bulk density of Jupiter, and follows an M1/3 − R relation like Jupiter. The F8IV star is a sub-giant star of 1.29 ± 0.09 solar masses and 1.95 ± 0.2 solar radii. The star and the planet exchange extremetidal forces that will lead...

An investigation of desalination by nanofiltration, reverse osmosis and integrated (hybrid NF/RO) membranes employed in brackish water treatment.

Science.gov (United States)

Talaeipour, M; Nouri, J; Hassani, A H; Mahvi, A H

2017-01-01

As an appropriate tool, membrane process is used for desalination of brackish water, in the production of drinking water. The present study aims to investigate desalination processes of brackish water of Qom Province in Iran. This study was carried out at the central laboratory of Water and Wastewater Company of the studied area. To this aim, membrane processes, including nanofiltration (NF) and reverse osmosis (RO), separately and also their hybrid process were applied. Moreover, water physical and chemical parameters, including salinity, total dissolved solids (TDS), electric conductivity (EC), Na +1 and Cl -1 were also measured. Afterward, the rejection percent of each parameter was investigated and compared using nanofiltration and reverse osmosis separately and also by their hybrid process. The treatment process was performed by Luna domestic desalination device, which its membrane was replaced by two NF90 and TW30 membranes for nanofiltration and reverse osmosis processes, respectively. All collected brackish water samples were fed through membranes NF90-2540, TW30-1821-100(RO) and Hybrid (NF/RO) which were installed on desalination household scale pilot (Luna water 100GPD). Then, to study the effects of pressure on permeable quality of membranes, the simulation software model ROSA was applied. Results showed that percent of the salinity rejection was recorded as 50.21%; 72.82 and 78.56% in NF, RO and hybrid processes, respectively. During the study, in order to simulate the performance of nanofiltartion, reverse osmosis and hybrid by pressure drive, reverse osmosis system analysis (ROSA) model was applied. The experiments were conducted at performance three methods of desalination to remove physic-chemical parameters as percentage of rejections in the pilot plant are: in the NF system the salinity 50.21, TDS 43.41, EC 43.62, Cl 21.1, Na 36.15, and in the RO membrane the salinity 72.02, TDS 60.26, EC 60.33, Cl 43.08, Na 54.41. Also in case of the rejection in

Assessment of the Clinical Trainer as a Role Model: A Role Model Apperception Tool (RoMAT)

NARCIS (Netherlands)

Jochemsen-van der Leeuw, H. G. A. Ria; van Dijk, Nynke; Wieringa-de Waard, Margreet

2014-01-01

Purpose Positive role modeling by clinical trainers is important for helping trainees learn professional and competent behavior. The authors developed and validated an instrument to assess clinical trainers as role models: the Role Model Apperception Tool (RoMAT). Method On the basis of a 2011

Charles Darwin, Imperium Britannicum a Evropa. K Darwinovu dvojitému výročí

Czech Academy of Sciences Publication Activity Database

Hermann, Tomáš; Stella, M.

2009-01-01

Roč. 42, č. 2 (2009), s. 103-111 ISSN 0300-4414 R&D Projects: GA AV ČR KJB800630701 Institutional research plan: CEZ:AV0Z80630520 Keywords : Darwin´s theory * history of biology * reception of Darwinism Subject RIV: AB - History

Restriction of the use of hazardous substances (RoHS in the personal computer segment: analysis of the strategic adoption by the manufacturers settled in Brazil

Directory of Open Access Journals (Sweden)

Ademir Brescansin

2015-09-01

Full Text Available The enactment of the RoHS Directive (Restriction of Hazardous Substances in 2003, limiting the use of certain hazardous substances in electronic equipment has forced companies to adjust their products to comply with this legislation. Even in the absence of similar legislation in Brazil, manufacturers of personal computers which are located in this country have been seen to adopt RoHS for products sold in the domestic market and abroad. The purpose of this study is to analyze whether these manufacturers have really adopted RoHS, focusing on their motivations, concerns, and benefits. This is an exploratory study based on literature review and interviews with HP, Dell, Sony, Lenovo, Samsung, LG, Itautec, and Positivo, using summative content analysis. The results showed that initially, global companies adopted RoHS to market products in Europe, and later expanded this practice to all products. Brazilian companies, however, adopted RoHS to participate in the government’s sustainable procurement bidding processes. It is expected that this study can assist manufacturers in developing strategies for reducing or eliminating hazardous substances in their products and processes, as well as help the government to formulate public policies on reducing risks of environmental contamination.

Effects of the GluN2B-NMDA receptor antagonist Ro 25-6981 on two types of behavioral flexibility in rats.

Science.gov (United States)

Clark, Emma; Antoniak, Kristen; Feniquito, Alyssandra; Dringenberg, Hans C

2017-02-15

Recent evidence has implicated N-methyl-d-aspartate receptors (NMDARs) in several aspects of learning and behavioral flexibility in rodents. Here, we examined the effects of treatment with Ro 25-6981, a selective antagonist of NMDARs containing GluN2B subunits, on two types of behavioral flexibility in rats, spatial reversal learning and set-shifting (spatial vs. motor strategy). To examine spatial reversal learning, rats were trained to swim to a hidden platform in a water maze over four days. On the following day, the platform was moved to a new location in the maze. Administration of Ro 25-6981 (10mg/kg) selectively impaired the early phase of reversal learning, but all rats learned to navigate to the new platform location over 12 trials. To examine set-shifting, independent groups of rats were trained to either swim to a fixed location (spatial strategy) or use a motor response (e.g., "turn left"; motor strategy) to find a hidden escape platform in a cross-shaped water maze apparatus; after task acquisition, rats were trained on the second, novel strategy (set-shift) following treatment with either Ro 25-6981 (10mg/kg) or saline. Administration of Ro 25-6981 had no effect on the ability of rats to perform the set-shift and use the new strategy to locate the escape platform. These results suggest that, in rats, spatial reversal learning, but not set-shifting, is sensitive to Ro-25-6981 treatment. Thus, NMDARs-GluN2B signaling may play a selective role in some forms of behavioral plasticity, particularly for situations involving the updating of information in the spatial domain. Copyright © 2016 Elsevier B.V. All rights reserved.

SCRUBBERS AS SHIPOWNERS’ RESPONSE TO THE SULPHUR DIRECTIVE AND ITS IMPLICATIONS FOR THE WASTE MANAGEMENT IN BALTIC PORTS

Directory of Open Access Journals (Sweden)

Magdalena Klopott

2015-12-01

Full Text Available The paper investogates the recent developments in exhaust gas cleaning systems and the growing interests in scrubber installation among ferry and ro-ro shipowners operating on the Baltic Sea. This technology creates the need for reception of scrubber sludge, which is produced alongside with gas cleaning. The study states that the information about the disposal of scrubber waste is largely limited or vague and evaluates – on the basis of a questionnaire - the availability of port reception facilities for the disposal of waste from sulphur scrubbers at major Baltic Sea ports. The paper concludes that a review of current legislature on port reception facilities is absolutely necessary and expresses the hope that the situation will improve in the wake of recent environmental regulations.

Technical aspects of coupling a 6300 m3/day MSF-RO desalination plant to a PHWR nuclear power plant

International Nuclear Information System (INIS)

Verma, R.K.

1998-01-01

Presently, eight pressurised Heavy Water Reactors (PHWRs) each of 235 MWe capacity are operational in India. Four more units of similar capacity are expected to be commissioned soon. Work on two units each of 500 MWe capacity is also initiated. Extensive engineering development work has also been carried out in India, both on the MSF process and the membrane process. Based on the experience obtained from the presently operating 425 m 3 /d MSF plant and from the R and D work on the RO process, a 6300 m 3 /d MSF-RO plant (4500 m 3 /d MSF and 1800 m 3 /d RO) has been designed and the work for setting up this plant is undertaken. The steam for the heating duty in the brine heater as well as the steam for the evacuation purpose for the MSF plant is proposed to be obtained from the nuclear plant steam cycle. Sea water feed for the MSF plant as well as for the RO plant will be derived from the sea water discharge system of the nuclear power plant. Provision is made for supply of electrical power also from the power plant. The details of the heating steam supply circuit starting from the steam tapping point on the nuclear plant side to the MSF plant brine heater inlet and the arrangement for the return of condensate to the nuclear plant has been described with component requirement and various technical considerations. All the liquid streams and the steam supplied from the nuclear plant to the desalination plant as well as the product water will be monitored to ensure that there is no radioactive contamination. (author)

Application and Limitations of GPS Radio Occultation (GPS-RO) Data for Atmospheric Boundary Layer Height Detection over the Arctic.

Science.gov (United States)

Ganeshan, M.; Wu, D. L.

2014-12-01

Due to recent changes in the Arctic environment, it is important to monitor the atmospheric boundary layer (ABL) properties over the Arctic Ocean, especially to explore the variability in ABL clouds (such as sensitivity and feedback to sea ice loss). For example, radiosonde and satellite observations of the Arctic ABL height (and low-cloud cover) have recently suggested a positive response to sea ice loss during October that may not occur during the melt season (June-September). Owing to its high vertical and spatiotemporal resolution, an independent ABL height detection algorithm using GPS Radio Occultation (GPS-RO) refractivity in the Arctic is explored. Similar GPS-RO algorithms developed previously typically define the level of the most negative moisture gradient as the ABL height. This definition is favorable for subtropical oceans where a stratocumulus-topped ABL is often capped by a layer of sharp moisture lapse rate (coincident with the temperature inversion). The Arctic Ocean is also characterized by stratocumulus cloud cover, however, the specific humidity does not frequently decrease in the ABL capping inversion. The use of GPS-RO refractivity for ABL height retrieval therefore becomes more complex. During winter months (December-February), when the total precipitable water in the troposphere is a minimum, a fairly straightforward algorithm for ABL height retrieval is developed. The applicability and limitations of this method for other seasons (Spring, Summer, Fall) is determined. The seasonal, interannual and spatial variability in the GPS-derived ABL height over the Arctic Ocean, as well as its relation to the underlying surface (ice vs. water), is investigated. The GPS-RO profiles are also explored for the evidence of low-level moisture transport in the cold Arctic environment.

Tight ceramic UF membrane as RO pre-treatment: The role of electrostatic interactions on phosphate rejection

NARCIS (Netherlands)

Shang, R.; Verliefde, A.R.D.; Hu, J.; Zeng, Z; Lu, L.; Lu, L.; Kemperman, Antonius J.B.; Deng, H.; Nijmeijer, Dorothea C.; Heijman, S.G.J.; Rietveld, L.C.

2014-01-01

Phosphate limitation has been reported as an effective approach to inhibit biofouling in reverse osmosis (RO) systems for water purification. The rejection of dissolved phosphate by negatively charged TiO2 tight ultrafiltration (UF) membranes (1 kDa and 3 kDa) was observed. These membranes can

Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA-positive mothers.

Science.gov (United States)

Skog, Amanda; Tingström, Joanna; Salomonsson, Stina; Sonesson, Sven-Erik; Wahren-Herlenius, Marie

2013-01-01

To define factors influencing neurodevelopment in children with and without complete congenital heart block (CHB) born to mothers with Ro/SSA autoantibodies. Medical records of a population-based cohort of siblings with (n = 60) and without (n = 54) CHB born 1974-2009 to anti-Ro/SSA-positive mothers were retrieved from children primary healthcare centres and school health services and used to extract data on neurodevelopment. Impaired neurodevelopment was reported in 16% of the children (18/114) during the follow-up time of 13.0 (8.2-17.5) years, median (quartiles). Reported problems included speech (9%), motor (8%) and learning (8%) impairment, attention deficit (5%) and behavioural impairment (4%). Impairment in motor skill development was more common in boys (p influenced by maternal SLE (p influenced by both maternal SLE (p influence neurodevelopment. Follow-up of neurodevelopment should therefore be considered for children with CHB, especially if the mother is diagnosed with SLE. ©2012 The Author(s)/Acta Paediatrica ©2012 Foundation Acta Paediatrica.

Remission of congenital complete heart block without anti-Ro/La antibodies: A case report

Directory of Open Access Journals (Sweden)

Souvik Mitra

2013-01-01

Full Text Available Anti-Ro/La negative congenital heart block (CHB is uncommon. We report one such case of CHB, with no associated structural heart disease or maternal autoantibodies. The heart block reverted to sinus rhythm spontaneously at two weeks of age, and the patient remains in sinus rhythm at a one year followup. Whether patients with antibody negative complete heart block have a different clinical course is conjectural.

Radical chemistry at a rural site (Wangdu) in the North China Plain: observation and model calculations of OH, HO2 and RO2 radicals

Science.gov (United States)

Tan, Zhaofeng; Fuchs, Hendrik; Lu, Keding; Hofzumahaus, Andreas; Bohn, Birger; Broch, Sebastian; Dong, Huabin; Gomm, Sebastian; Häseler, Rolf; He, Lingyan; Holland, Frank; Li, Xin; Liu, Ying; Lu, Sihua; Rohrer, Franz; Shao, Min; Wang, Baolin; Wang, Ming; Wu, Yusheng; Zeng, Limin; Zhang, Yinsong; Wahner, Andreas; Zhang, Yuanhang

2017-01-01

A comprehensive field campaign was carried out in summer 2014 in Wangdu, located in the North China Plain. A month of continuous OH, HO2 and RO2 measurements was achieved. Observations of radicals by the laser-induced fluorescence (LIF) technique revealed daily maximum concentrations between (5-15) × 106 cm-3, (3-14) × 108 cm-3 and (3-15) × 108 cm-3 for OH, HO2 and RO2, respectively. Measured OH reactivities (inverse OH lifetime) were 10 to 20 s-1 during daytime. The chemical box model RACM 2, including the Leuven isoprene mechanism (LIM), was used to interpret the observed radical concentrations. As in previous field campaigns in China, modeled and measured OH concentrations agree for NO mixing ratios higher than 1 ppbv, but systematic discrepancies are observed in the afternoon for NO mixing ratios of less than 300 pptv (the model-measurement ratio is between 1.4 and 2 in this case). If additional OH recycling equivalent to 100 pptv NO is assumed, the model is capable of reproducing the observed OH, HO2 and RO2 concentrations for conditions of high volatile organic compound (VOC) and low NOx concentrations. For HO2, good agreement is found between modeled and observed concentrations during day and night. In the case of RO2, the agreement between model calculations and measurements is good in the late afternoon when NO concentrations are below 0.3 ppbv. A significant model underprediction of RO2 by a factor of 3 to 5 is found in the morning at NO concentrations higher than 1 ppbv, which can be explained by a missing RO2 source of 2 ppbv h-1. As a consequence, the model underpredicts the photochemical net ozone production by 20 ppbv per day, which is a significant portion of the daily integrated ozone production (110 ppbv) derived from the measured HO2 and RO2. The additional RO2 production from the photolysis of ClNO2 and missing reactivity can explain about 10 % and 20 % of the discrepancy, respectively. The underprediction of the photochemical ozone

Immunization with 60 kD Ro peptide produces different stages of preclinical autoimmunity in a Sjögren's syndrome model among multiple strains of inbred mice.

Science.gov (United States)

Kurien, B T; Dsouza, A; Igoe, A; Lee, Y J; Maier-Moore, J S; Gordon, T; Jackson, M; Scofield, R H

2013-07-01

Sjögren's syndrome is a chronic illness manifested characteristically by immune injury to the salivary and lacrimal glands, resulting in dry mouth/eyes. Anti-Ro [Sjögren's syndrome antigen A (SSA)] and anti-La [Sjögren's syndrome antigen B (SSB)] autoantibodies are found frequently in Sjögren's subjects as well as in individuals who will go on to develop the disease. Immunization of BALB/c mice with Ro60 peptides results in epitope spreading with anti-Ro and anti-La along with lymphocyte infiltration of salivary glands similar to human Sjögren's. In addition, these animals have poor salivary function/low saliva volume. In this study, we examined whether Ro-peptide immunization produces a Sjögren's-like illness in other strains of mice. BALB/c, DBA-2, PL/J, SJL/J and C57BL/6 mice were immunized with Ro60 peptide-274. Sera from these mice were studied by immunoblot and enzyme-linked immunosorbent assay for autoantibodies. Timed salivary flow was determined after pharmacological stimulation, and salivary glands were examined pathologically. We found that SJL/J mice had no immune response to the peptide from Ro60, while C57BL/6 mice produced antibodies that bound the peptide but had no epitope spreading. PL/J mice had epitope spreading to other structures of Ro60 as well as to La, but like C57BL/6 and SJL/J had no salivary gland lymphocytic infiltration and no decrement of salivary function. DBA-2 and BALB/c mice had infiltration but only BALB/c had decreased salivary function. The immunological processes leading to a Sjögren's-like illness after Ro-peptide immunization were interrupted in a stepwise fashion in these differing mice strains. These data suggest that this is a model of preclinical disease with genetic control for epitope spreading, lymphocytic infiltration and glandular dysfunction. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.

Toll-like receptor 3 stimulation promotes Ro52/TRIM21 synthesis and nuclear redistribution in salivary gland epithelial cells, partially via type I interferon pathway

Science.gov (United States)

Kyriakidis, N C; Kapsogeorgou, E K; Gourzi, V C; Konsta, O D; Baltatzis, G E; Tzioufas, A G

2014-01-01

Up-regulated expression of Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2) and lupus LA protein/Sjögren's syndrome antigen B (La/SSB) autoantigens has been described in the salivary gland epithelial cells (SGEC) of patients with Sjögren's syndrome (SS). SGECs, the key regulators of autoimmune SS responses, express high levels of surface functional Toll-like receptor (TLR)-3, whereas Ro52/TRIM21 negatively regulates TLR-3-mediated inflammation. Herein, we investigated the effect of TLR-3-signalling on the expression of Ro52/TRIM21, as well as Ro60/TROVE2 and La/SSB autoantigens, by SGECs. The effect of TLR-3 or TLR-4 stimulation on autoantigen expression was evaluated by polyI:C or lipopolysaccharide (LPS) treatment, respectively, of SGEC lines (10 from SS patients, 12 from non-SS controls) or HeLa cells, followed by analysis of mRNA and protein expression. PolyI:C, but not LPS, resulted in a two-step induction of Ro52/TRIM21 mRNA expression by SGECs, a 12-fold increment at 6 h followed by a 2·5-fold increment at 24–48 h, whereas it induced a late two-fold up-regulation of Ro60/TROVE2 and La/SSB mRNAs at 48 h. Although protein expression levels were not affected significantly, the late up-regulation of Ro52/TRIM21 mRNA was accompanied by protein redistribution, from nucleolar-like pattern to multiple coarse dots spanning throughout the nucleus. These late phenomena were mediated significantly by interferon (IFN)-β production, as attested by cognate secretion and specific inhibition experiments and associated with IFN regulatory factor (IRF)3 degradation. TLR-3-signalling had similar effects on SGECs obtained from SS patients and controls, whereas it did not affect the expression of these autoantigens in HeLa cells. TLR-3 signalling regulates the expression of autoantigens by SGECs, implicating innate immunity pathways in their over-expression in inflamed tissues and possibly in their exposure to the immune

Tight ceramic UF membrane as RO pre-treatment: the role of electrostatic interactions on phosphate rejection.

Science.gov (United States)

Shang, Ran; Verliefde, Arne R D; Hu, Jingyi; Zeng, Zheyi; Lu, Jie; Kemperman, Antoine J B; Deng, Huiping; Nijmeijer, Kitty; Heijman, Sebastiaan G J; Rietveld, Luuk C

2014-01-01

Phosphate limitation has been reported as an effective approach to inhibit biofouling in reverse osmosis (RO) systems for water purification. The rejection of dissolved phosphate by negatively charged TiO2 tight ultrafiltration (UF) membranes (1 kDa and 3 kDa) was observed. These membranes can potentially be adopted as an effective process for RO pre-treatment in order to constrain biofouling by phosphate limitation. This paper focuses on electrostatic interactions during tight UF filtration. Despite the larger pore size, the 3 kDa ceramic membrane exhibited greater phosphate rejection than the 1 kDa membrane, because the 3 kDa membrane has a greater negative surface charge and thus greater electrostatic repulsion against phosphate. The increase of pH from 6 to 8.5 led to a substantial increase in phosphate rejection by both membranes due to increased electrostatic repulsion. At pH 8.5, the maximum phosphate rejections achieved by the 1 kDa and 3 kDa membrane were 75% and 86%, respectively. A Debye ratio (ratio of the Debye length to the pore radius) is introduced in order to evaluate double layer overlapping in tight UF membranes. Threshold Debye ratios were determined as 2 and 1 for the 1 kDa and 3 kDa membranes, respectively. A Debye ratio below the threshold Debye ratio leads to dramatically decreased phosphate rejection by tight UF membranes. The phosphate rejection by the tight UF, in combination with chemical phosphate removal by coagulation, might accomplish phosphate-limited conditions for biological growth and thus prevent biofouling in the RO systems. Copyright © 2013 Elsevier Ltd. All rights reserved.

Influence of changes in humidity on dry temperature in GPS RO climatologies

Directory of Open Access Journals (Sweden)

J. Danzer

2014-09-01

Full Text Available Radio occultation (RO data are increasingly used in climate research. Accurate phase (change measurements of Global Positioning System (GPS signals are the basis for the retrieval of near-vertical profiles of bending angle, microwave refractivity, density, pressure, and temperature. If temperature is calculated from observed refractivity with the assumption that water vapor is zero, the product is called "dry temperature", which is commonly used to study earth's atmosphere, e.g., when analyzing temperature trends due to global warming. Dry temperature is a useful quantity, since it does not need additional background information in its retrieval. However, it can only be safely used as proxy for physical temperature, where moisture is negligible. The altitude region above which water vapor does not play a dominant role anymore, depends primarily on latitude and season. In this study we first investigated the influence of water vapor on dry temperature RO profiles. Hence, we analyzed the maximum altitude down to which monthly mean dry temperature profiles can be regarded as being equivalent to physical temperature. This was done by examining dry temperature to physical temperature differences of monthly mean analysis fields from the European Centre for Medium-Range Weather Forecasts (ECMWF, studied from 2006 until 2010. We introduced cutoff criteria, where maximum temperature differences of −0.1, −0.05, and −0.02 K were allowed (dry temperature is always lower than physical temperature, and computed the corresponding altitudes. As an example, a temperature difference of −0.05 K in the tropics was found at an altitude of about 14 km, while at higher northern latitudes in winter it was found at an altitude of about 9–10 km, in summer at about 11 km. Furthermore, regarding climate change, we expect an increase of absolute humidity in the atmosphere. This possible trend in water vapor could yield a wrongly interpreted dry temperature trend

Effects of RoHs and REACH regulations on firm-level production and export, and the role of global value chains : the cases of Malaysia and Vietnam

OpenAIRE

Otsuki, Tsunehiro; Honda, Keiichiro; Michida, Etsuyo; Nabeshima, Kaoru; Ueki, Yasushi

2015-01-01

This paper uses firm-level data to examine the impact of foreign chemical safety regulations such as RoHS and REACH on the production costs and export performance of firms in Malaysia and Vietnam. This paper also investigates the role of global value chains in enhancing the likelihood that a firm complies with RoHS and REACH. We find that in addition to the initial setup costs for compliance, EU RoHS (REACH) implementation imposes on firms additional variable production costs by requiring add...

ÜRO säästva arengu eesmärgid aastaks 2030 / Meelis Joost

Index Scriptorium Estoniae

Joost, Meelis

2016-01-01

ÜRO liikmesriikide juhid leppisid 25.‒27. septembril 2015 New Yorgis kokku säästva arengu eesmärkides, mis tuleb saavutada 2030. aastaks. Säästva arengu eesmärgid on kaudselt seotud ka puuetega inimestega. Eesti Puuetega Inimeste Koda huvitab, kuivõrd ligipääsetavus, puuetega inimeste elukvaliteet, kasvav kaasatus ühiskonda ning puuetega inimestele osutatavate sotsiaalteenuste kvaliteet leiab kajastamist säästva arengu tegevuskava elluviimises

Study of microRNAs (miRNAs) that are predicted to target the autoantigens Ro/SSA and La/SSB in primary Sjögren’s Syndrome

Science.gov (United States)

Gourzi, V C; Kapsogeorgou, E K; Kyriakidis, N C; Tzioufas, A G

2015-01-01

The elevated tissue expression of Ro/SSA and La/SSB autoantigens appears to be crucial for the generation and perpetuation of autoimmune humoral responses against these autoantigens in Sjögren’s syndrome (SS). The mechanisms that govern their expression are not known. miRNAs, the post-transcriptional regulators of gene expression, might be implicated. We have identified previously the miRNAs let7b, miR16, miR181a, miR200b-3p, miR200b-5p, miR223 and miR483-5p that are predicted to target Ro/SSA [Ro52/tripartite motif-containing protein 21 (TRIM21), Ro60/TROVE domain family, member 2 (TROVE2)] and La/SSB mRNAs. To study possible associations with autoantigen mRNA expression and disease features, their expression was investigated in minor salivary gland (MSG) tissues, peripheral blood mononuclear cells (PBMC) and long-term cultured non-neoplastic salivary gland epithelial cells (SGEC) from 29 SS patients (20 of 29 positive for autoantibodies to Ro/SSA and La/SSB) and 24 sicca-complaining controls. The levels of miR16 were up-regulated in MSGs, miR200b-3p in SGECs and miR223 and miR483-5p in PBMCs of SS patients compared to sicca-complaining controls. The MSG levels of let7b, miR16, miR181a, miR223 and miR483-5p were correlated positively with Ro52/TRIM21-mRNA. miR181a and miR200b-3p were correlated negatively with Ro52/TRIM21 and Ro60/TROVE2 mRNAs in SGECs, respectively, whereas let7b, miR200b-5p and miR223 associated with La/SSB-mRNA. In PBMCs, let7b, miR16, miR181a and miR483-5p were correlated with Ro52/TRIM21, whereas let7b, miR16 and miR181a were also associated with La/SSB-mRNA expression. Significantly lower miR200b-5p levels were expressed in SS patients with mucosa-associated lymphoid tissue (MALT) lymphoma compared to those without. Our findings indicate that miR16, miR200b-3p, miR223 and miR483-5p are deregulated in SS, but the exact role of this deregulation in disease pathogenesis and autoantigen expression needs to be elucidated. PMID:26201309

Efficient ConvNet Feature Extraction with Multiple RoI Pooling for Landmark-Based Visual Localization of Autonomous Vehicles

Directory of Open Access Journals (Sweden)

Yi Hou

2017-01-01

Full Text Available Efficient and robust visual localization is important for autonomous vehicles. By achieving impressive localization accuracy under conditions of significant changes, ConvNet landmark-based approach has attracted the attention of people in several research communities including autonomous vehicles. Such an approach relies heavily on the outstanding discrimination power of ConvNet features to match detected landmarks between images. However, a major challenge of this approach is how to extract discriminative ConvNet features efficiently. To address this challenging, inspired by the high efficiency of the region of interest (RoI pooling layer, we propose a Multiple RoI (MRoI pooling technique, an enhancement of RoI, and a simple yet efficient ConvNet feature extraction method. Our idea is to leverage MRoI pooling to exploit multilevel and multiresolution information from multiple convolutional layers and then fuse them to improve the discrimination capacity of the final ConvNet features. The main advantages of our method are (a high computational efficiency for real-time applications; (b GPU memory efficiency for mobile applications; and (c use of pretrained model without fine-tuning or retraining for easy implementation. Experimental results on four datasets have demonstrated not only the above advantages but also the high discriminating power of the extracted ConvNet features with state-of-the-art localization accuracy.

Adsorption of pharmaceuticals onto isolated polyamide active layer of NF/RO membranes.

Science.gov (United States)

Liu, Yan-Ling; Wang, Xiao-Mao; Yang, Hong-Wei; Xie, Yuefeng F

2018-06-01

Adsorption of trace organic compounds (TrOCs) onto the membrane materials has a great impact on their rejection by nanofiltration (NF) and reverse osmosis (RO) membranes. This study aimed to investigate the difference in adsorption of various pharmaceuticals (PhACs) onto different NF/RO membranes and to demonstrate the necessity of isolating the polyamide (PA) active layer from the polysulfone (PS) support layer for adsorption characterization and quantification. Both the isolated PA layers and the PA+PS layers of NF90 and ESPA1 membranes were used to conduct static adsorption tests. Results showed that apparent differences existed between the PA layer and the PA+PS layer in the adsorption capacity of PhACs as well as the time necessary to reach the adsorption equilibrium. PhACs with different physicochemical properties could be adsorbed to different extents by the isolated PA layer, which was mainly attributed to electrostatic attraction/repulsion and hydrophobic interactions. The PA layer of ESPA1 exhibited apparently higher adsorption capacities for the positively charged PhACs and similar adsorption capacities for the neutral PhACs although it had significantly less total interfacial area (per unit membrane surface area) for adsorption compared to the PA layer of NF90. The higher affinity of the PA layer of ESPA1 for the PhACs could be due to its higher capacity of forming hydrogen bonds with PhACs resulted from the modified chemistry with more -OH groups. This study provides a novel approach to determining the TrOC adsorption onto the active layer of membranes for the ease of investigating adsorption mechanisms. Copyright © 2018 Elsevier Ltd. All rights reserved.

INSTITUTIONAL BARRIERS TO EFFICIENT POLICY INTERVENTION IN THE EUROPEAN PORT SECTOR

Directory of Open Access Journals (Sweden)

Barry UBBELS

2005-01-01

Full Text Available Despite the growing role of private involvement in recent port developments, most maritime trade is still largely handled in ports where investments, pricing and other managerial decisions are, to a varying extent, dependent, or at least influenced by public bodies. This paper shows that the extent and type of public intervention differs considerably between ports in the Hamburg-Le Havre range. The wide variety in ownership, financing and management of ports throughout Europe indicates that there is no level playing field at present. Because ports operate in an increasingly competitive environment (intensified by globalisation trends and the completion of the internal market, this may lead to situations of unfair competition. The European Union emphasises the importance of a more harmonised approach of port regulation by national governments (in terms of financing and pricing of infrastructure. Given the differences in (national port management styles and the low levels of transparency, the creation of a level playing field in the European port industry seems far away. This suggests the presence of a major institutional difference in European transport policy that hampers efficient policy intervention.

SDN based millimetre wave radio over fiber (RoF) network

Science.gov (United States)

Amate, Ahmed; Milosavljevic, Milos; Kourtessis, Pandelis; Robinson, Matthew; Senior, John M.

2015-01-01

This paper introduces software-defined, millimeter Wave (mm-Wave) networks with Radio over Fiber (RoF) for the delivery of gigabit connectivity required to develop fifth generation (5G) mobile. This network will enable an effective open access system allowing providers to manage and lease the infrastructure to service providers through unbundling new business models. Exploiting the inherited benefits of RoF, complete base station functionalities are centralized at the edges of the metro and aggregation network, leaving remote radio heads (RRHs) with only tunable filtering and amplification. A Software Defined Network (SDN) Central Controller (SCC) is responsible for managing the resource across several mm-Wave Radio Access Networks (RANs) providing a global view of the several network segments. This ensures flexible resource allocation for reduced overall latency and increased throughput. The SDN based mm-Wave RAN also allows for inter edge node communication. Therefore, certain packets can be routed between different RANs supported by the same edge node, reducing latency. System level simulations of the complete network have shown significant improvement of the overall throughput and SINR for wireless users by providing effective resource allocation and coordination among interfering cells. A new Coordinated Multipoint (CoMP) algorithm exploiting the benefits of the SCC global network view for reduced delay in control message exchange is presented, accounting for a minimum packet delay and limited Channel State Information (CSI) in a Long Term Evolution-Advanced (LTE-A), Cloud RAN (CRAN) configuration. The algorithm does not require detailed CSI feedback from UEs but it rather considers UE location (determined by the eNB) as the required parameter. UE throughput in the target sector is represented using a Cumulative Distributive Function (CDF). The drawn characteristics suggest that there is a significant 60% improvement in UE cell edge throughput following the

Confronting Illegal, Unreported and Unregulated (IUU) fishing with proper port and flagged states policies: The case of South Korea and European Union

Czech Academy of Sciences Publication Activity Database

Midani, Rahimi Amaj; Lee, S.G.

2016-01-01

Roč. 10, č. 3 (2016), s. 43-51 E-ISSN 1307-234X Institutional support: RVO:60077344 Keywords : illegal unreported and unregulated * South Korea * distant water fishing * European Union * normative power * market power Subject RIV: GL - Fishing www. fisheries sciences.com

Membrane fouling and anti-fouling strategies using RO retentate from a municipal water recycling plant as the feed for osmotic power generation

KAUST Repository

Chen, Si Cong

2015-10-25

RO retentate from a municipal water recycling plant is considered as a potential feed stream for osmotic power generation in this paper. The feasibility of using RO retentate from a municipal water recycling plant was examined from two aspects: (a) the membrane fouling propensity of RO retentate, and (b) the efficacy of anti-fouling strategies. The membranes used in this study were the inner selective thin film composite polyethersulfone (TFC/PES) hollow fiber membranes, which possessed a high water permeability and good mechanical strength. Scaling by phosphate salts was found to be one possible inorganic fouling on the innermost layer of the PES membrane, whereas silica fouling was observed to be the governing fouling on the outmost surface of the PES membrane. Two anti-fouling pretreatments, i.e., pH adjustment and anti-scalant pre-treatment for the feed stream, were studied and found to be straightforward and effective. Using RO retentate at pH 7.2 as the feed and 1 M NaCl as the draw solution, the average power density was 7.3 W/m at 20 bar. The average power density increased to 12.6 W/m by modifying RO retentate with an initial pH value of 5.5 using HCl and to 13.4 W/m by adding 1.1 mM ethylenediaminetetraacetic acid (EDTA). Moreover, the flux recovery of the fouled membranes, without the indicated pretreatments, reached 84.9% using deionized (DI) water flushing and 95.0% using air bubbling under a high crossflow velocity of 23.3 cm/s (Re = 2497) for 30 min. After pretreatment by pH adjustment, the flux recovery increased to 94.6% by DI water flushing and 100.0% by air bubbling. After pretreatment by adding 1.1 mM EDTA into RO retentate, flux was almost fully restored by physical cleaning by DI water flushing and air bubbling. These results provide insight into developing an effective pretreatment by either pH adjustment or EDTA addition before PRO and physical cleaning methods by DI water flushing and air bubbling for membrane used in osmotic power

Membrane fouling and anti-fouling strategies using RO retentate from a municipal water recycling plant as the feed for osmotic power generation

KAUST Repository

Chen, Si Cong; Amy, Gary L.; Chung, Neal Tai-Shung

2015-01-01

RO retentate from a municipal water recycling plant is considered as a potential feed stream for osmotic power generation in this paper. The feasibility of using RO retentate from a municipal water recycling plant was examined from two aspects: (a) the membrane fouling propensity of RO retentate, and (b) the efficacy of anti-fouling strategies. The membranes used in this study were the inner selective thin film composite polyethersulfone (TFC/PES) hollow fiber membranes, which possessed a high water permeability and good mechanical strength. Scaling by phosphate salts was found to be one possible inorganic fouling on the innermost layer of the PES membrane, whereas silica fouling was observed to be the governing fouling on the outmost surface of the PES membrane. Two anti-fouling pretreatments, i.e., pH adjustment and anti-scalant pre-treatment for the feed stream, were studied and found to be straightforward and effective. Using RO retentate at pH 7.2 as the feed and 1 M NaCl as the draw solution, the average power density was 7.3 W/m at 20 bar. The average power density increased to 12.6 W/m by modifying RO retentate with an initial pH value of 5.5 using HCl and to 13.4 W/m by adding 1.1 mM ethylenediaminetetraacetic acid (EDTA). Moreover, the flux recovery of the fouled membranes, without the indicated pretreatments, reached 84.9% using deionized (DI) water flushing and 95.0% using air bubbling under a high crossflow velocity of 23.3 cm/s (Re = 2497) for 30 min. After pretreatment by pH adjustment, the flux recovery increased to 94.6% by DI water flushing and 100.0% by air bubbling. After pretreatment by adding 1.1 mM EDTA into RO retentate, flux was almost fully restored by physical cleaning by DI water flushing and air bubbling. These results provide insight into developing an effective pretreatment by either pH adjustment or EDTA addition before PRO and physical cleaning methods by DI water flushing and air bubbling for membrane used in osmotic power

Membrane fouling and anti-fouling strategies using RO retentate from a municipal water recycling plant as the feed for osmotic power generation.

Science.gov (United States)

Chen, Si Cong; Amy, Gary L; Chung, Tai-Shung

2016-01-01

RO retentate from a municipal water recycling plant is considered as a potential feed stream for osmotic power generation in this paper. The feasibility of using RO retentate from a municipal water recycling plant was examined from two aspects: (a) the membrane fouling propensity of RO retentate, and (b) the efficacy of anti-fouling strategies. The membranes used in this study were the inner selective thin film composite polyethersulfone (TFC/PES) hollow fiber membranes, which possessed a high water permeability and good mechanical strength. Scaling by phosphate salts was found to be one possible inorganic fouling on the innermost layer of the PES membrane, whereas silica fouling was observed to be the governing fouling on the outmost surface of the PES membrane. Two anti-fouling pretreatments, i.e., pH adjustment and anti-scalant pre-treatment for the feed stream, were studied and found to be straightforward and effective. Using RO retentate at pH 7.2 as the feed and 1 M NaCl as the draw solution, the average power density was 7.3 W/m(2) at 20 bar. The average power density increased to 12.6 W/m(2) by modifying RO retentate with an initial pH value of 5.5 using HCl and to 13.4 W/m(2) by adding 1.1 mM ethylenediaminetetraacetic acid (EDTA). Moreover, the flux recovery of the fouled membranes, without the indicated pretreatments, reached 84.9% using deionized (DI) water flushing and 95.0% using air bubbling under a high crossflow velocity of 23.3 cm/s (Re = 2497) for 30 min. After pretreatment by pH adjustment, the flux recovery increased to 94.6% by DI water flushing and 100.0% by air bubbling. After pretreatment by adding 1.1 mM EDTA into RO retentate, flux was almost fully restored by physical cleaning by DI water flushing and air bubbling. These results provide insight into developing an effective pretreatment by either pH adjustment or EDTA addition before PRO and physical cleaning methods by DI water flushing and air bubbling for membrane used in

Gold and Displacement in Eastern Europe: Risks and Uncertainty at Roşia Montană

Directory of Open Access Journals (Sweden)

FILIP ALEXANDRESCU

2011-01-01

Full Text Available The Canadian-Romanian gold mining project at Roşia Montanǎ in Romania is known as the largest opencast gold mine being planned now in Europe. It involves the displacement of several thousand inhabitants, mostly former gold miners and a smaller number of farmers. The land and houses of more than three quarters of this population have already been acquired by the project owners, although the project has not yet received its formal environmental clearance. The paper analyzes the risks facing the displaced population of Roşia Montană, employing as analytical methodology the Impoverishment Risks and Reconstruction (IRR model, developed by Michael M. Cernea. The paper argues for an expansion of the IRR model. By taking into account the macro (extralocal forces that shape displacement and paying closer attention to the micro (subjective experience of this process, it becomes possible to understand the effects of uncertainty and vulnerability in displacement. The author's participant observations and in-depth interviews with local families are complemented with secondary analyses of data from several other socio-economic surveys and with the analysis of the Resettlement and Relocation Action Plan of the project owners.

Impact of XPM Crosstalk on SCM-Based RoF Systems

Science.gov (United States)

Nain, Abhimanyu; Kumar, Suresh; Singla, Shelly

2017-08-01

Crosstalk effects in wavelength multiplexed subcarrier multiplexing radio-over-fiber (RoF) transmission system due to cross phase modulation (XPM) are investigated in the present paper. The crosstalk has been evaluated including the effects of dispersion along with its higher order terms (HOD) and walk-off parameter for different modulation frequencies and transmission distances. Results show that the crosstalk level can be as high as -43 dB after transmission over a 25 km of fiber with two wavelengths and 15 dBm per wavelength of transmitted power. An increment of 7 dB is observed with increase in walk-off parameter and 5 dB with increase in dispersion parameter. The crosstalk also depends upon spacing between optical wavelengths. Simulative investigation shows that increase in separation between wavelengths degrade the overall system performance, which limits the number of optical wavelengths that can be used in transmission system.

Removal of organic micro-pollutants (phenol, aniline and nitrobenzene) via forward osmosis (FO) process: Evaluation of FO as an alternative method to reverse osmosis (RO)

KAUST Repository

Cui, Yue

2016-01-05

In this study, we have explored and compared the effectiveness of using (1) lab-fabricated forward osmosis (FO) membranes under both FO and reverse osmosis (RO) modes and (2) commercially available RO membranes under the RO mode for the removal of organic micro-pollutants. The lab-fabricated FO membranes are thin film composite (TFC) membranes consisting of a polyamide layer and a porous substrate cast from three different materials; namely, Matrimid, polyethersulfone (PESU) and sulfonated polyphenylene sulfone (sPPSU). The results show that the FO mode is superior to the RO mode in the removal of phenol, aniline and nitrobenzene from wastewater. The rejections of all three TFC membranes to all the three organic micro-pollutants under the FO processes are higher than 72% and can be even higher than 90% for aniline when a 1000 ppm aromatic aqueous solution and 1 M NaCl are employed as feeds. These performances outperform the results obtained from themselves and commercially available RO membranes under the RO mode. In addition, the rejection can be maintained even when treating a more concentrated feed solution (2000 ppm). The removal performance can be further enhanced by using a more concentrated draw solution (2 M). The water flux is almost doubled, and the rejection increment can reach up to 17%. Moreover, it was observed that annealing as a post-treatment would help compact the membrane selective layer and further enhance the separating efficiency. The obtained organic micro-pollutant rejections and water fluxes under various feasible operating conditions indicate that the FO process has potential to be a viable treatment for wastewater containing organic micro-pollutants.

Rahvusvahelise terrorismi defineerimine ÜRO raames : [bakalaureusetöö] / Tuuli Pärnsalu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Kristi Land

Index Scriptorium Estoniae

Pärnsalu, Tuuli

2003-01-01

Rahvusvahelise terrorismi defineerimise tähtsus, inimõiguste kaitse, riikidevaheline koostöö terrorismi definitsiooni otsingutel, definitsiooni elemendid, riigiterrorismi kontseptsioon, riikidevahelise terrorismiga seotud vaidluste lahendamine ÜRO raames

DSP-based CSO cancellation technique for RoF transmission system implemented by using directly modulated laser.

Science.gov (United States)

Kim, Byung Gon; Bae, Sung Hyun; Kim, Hoon; Chung, Yun C

2017-05-29

We propose and demonstrate a simple composite second-order (CSO) cancellation technique based on the digital signal processing (DSP) for the radio-over-fiber (RoF) transmission system implemented by using directly modulated lasers (DMLs). When the RoF transmission system is implemented by using DMLs, its performance could be limited by the CSO distortions caused by the interplay between the DML's chirp and fiber's chromatic dispersion. We present the theoretical analysis of these nonlinear distortions and show that they can be suppressed at the receiver by using a simple DSP. To verify the effectiveness of the proposed technique, we demonstrate the transmission of twenty-four 100-MHz filtered orthogonal frequency-division multiplexing (f-OFDM) signals in 64 quadrature amplitude modulation (QAM) format over 20 km of the standard single-mode fiber (SSMF). The results show that, by using the proposed technique, we can suppress the CSO distortion components by >10 dB and achieve the error-vector magnitude performance better than 6% even after the 20-km long SSMF transmission.

Effect of pH and Pressure on Uranium Removal from Drinking Water Using NF/RO Membranes.

Science.gov (United States)

Schulte-Herbrüggen, Helfrid M A; Semião, Andrea J C; Chaurand, Perrine; Graham, Margaret C

2016-06-07

Groundwater is becoming an increasingly important drinking water source. However, the use of groundwater for potable purposes can lead to chronic human exposure to geogenic contaminants, for example, uranium. Nanofiltration (NF) and reverse osmosis (RO) processes are used for drinking water purification, and it is important to understand how contaminants interact with membranes since accumulation of contaminants to the membrane surface can lead to fouling, performance decline and possible breakthrough of contaminants. During the current study laboratory experiments were conducted using NF (TFC-SR2) and RO (BW30) membranes to establish the behavior of uranium across pH (3-10) and pressure (5-15 bar) ranges. The results showed that important determinants of uranium-membrane sorption interactions were (i) the uranium speciation (uranium species valence and size in relation to membrane surface charge and pore size) and (ii) concentration polarization, depending on the pH values. The results show that it is important to monitor sorption of uranium to membranes, which is controlled by pH and concentration polarization, and, if necessary, adjust those parameters controlling uranium sorption.

Estudo clínico-eletrencefalográfico longitudinal em pacientes epilépticos tratados com Ro 5-4023 Longitudinal clinical and electroencephalographieal studies in epileptic patients treated with Ro 5-4023

Directory of Open Access Journals (Sweden)

Michel P. Lison

1970-03-01

Full Text Available Estudaram-se as modificações do quadro clínico e do quadro eletrencefalográfico em 22 pacientes com manifestações epilépticas diárias (5 com ausências típicas, 3 com crises psicomotoras, 5 com ausências mioclônicas, 1 com mioclonias de ação e 8 com síndrome de Lennox, tratados com 7-nitro-5-(2clorofenil-3H-1,4 benzodiazepina 2 (1H-one ou Ro 5-4023. Vinte pacientes tinham sido submetidos a terapêuticas anticonvulsivantes usuais sem resultados apreciáveis. Com o uso de Ro 5-4023 as crises foram controladas desde o primeiro dia em 14 pacientes. Em mais 6 doentes houve redução rápida e significativa da intensidade e da freqüência das crises. Destes, um não mais apresentou manifestações a partir da segunda semana de tratamento. Recidivas parciais ocorreram em 8 pacientes. Destaca-se o amplo campo de ação da droga, que age nas epilepsias generalizadas (ausências típicas e ausências mioclônicas, em epilepsias parciais, particularmente crises psicomotoras da infância com ponta-ondas lentas, nas encefalopatias epilépticas graves da infância, de tipo Lennox, e também em síndrome epiléptico degenerativo. Os efeitos colaterais, presentes em 11 pacientes, foram passageiros em 9. Precipitação de crises generalizadas tônico-clônicas ocorreu em dois pacientes; contudo há indícios que esse fenômeno é mais freqüente com outros derivados benzodiazepínicos. As modificações do EEG incluiram desaparecimento ou diminuição das descargas bilaterais e difusas, espontâneas e/ou desencadeadas pela estimulação luminosa intermitente, aparecimento de ritmos rápidos e difusos, persistência ou aparecimento de anormalidades focais lentas ou de tipo irritativo.Twenty two epileptic patients, with daily seizures (5 had typical absences, 3 had psychomotor seizures, 5 had myoclonic absences, one had intentional myoclonia and 8 had Lennox syndrome were treated with 7-nitro-5-(2chlorophenyl-3H-1,4 benzodiazepine-2(1H-one or Ro 5

TU-CD-BRD-04: UCLA Experience, with Focus On Developing Metrics and Using RO-ILS

International Nuclear Information System (INIS)

Beron, P.

2015-01-01

It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

TU-CD-BRD-04: UCLA Experience, with Focus On Developing Metrics and Using RO-ILS

Energy Technology Data Exchange (ETDEWEB)

Beron, P. [University of California, Los Angeles (United States)

2015-06-15

It has long been standard practice in radiation oncology to report internally when a patient’s treatment has not gone as planned and to report events to regulatory agencies when legally required. Most potential errors are caught early and never affect the patient. Quality assurance steps routinely prevent errors from reaching the patient, and these “near misses” are much more frequent than treatment errors. A growing number of radiation oncology facilities have implemented incident learning systems to report and analyze both errors and near misses. Using the term “incident learning” instead of “event reporting” emphasizes the need to use these experiences to change the practice and make future errors less likely and promote an educational, non-punitive environment. There are challenges in making such a system practical and effective. Speakers from institutions of different sizes and practice environments will share their experiences on how to make such a system work and what benefits their clinics have accrued. Questions that will be addressed include: How to create a system that is easy for front line staff to access How to motivate staff to report How to promote the system as positive and educational and not punitive or demeaning How to organize the team for reviewing and responding to reports How to prioritize which reports to discuss in depth How not to dismiss the rest How to identify underlying causes How to design corrective actions and implement change How to develop useful statistics and analysis tools How to coordinate a departmental system with a larger risk management system How to do this without a dedicated quality manager Some speakers’ experience is with in-house systems and some will share experience with the AAPM/ASTRO national Radiation Oncology Incident Learning System (RO-ILS). Reports intended to be of value nationally need to be comprehensible to outsiders; examples of useful reports will be shown. There will be ample time set

Geochronology and characteristics of Ni-Cu-(PGE) mineralization at Rožany, Lusatian Granitoid Complex, Czech Republic

Czech Academy of Sciences Publication Activity Database

Haluzová, Eva; Ackerman, Lukáš; Pašava, J.; Jonášová, Šárka; Svojtka, Martin; Hrstka, Tomáš; Veselovský, F.

2015-01-01

Roč. 60, č. 4 (2015), s. 219-236 ISSN 1802-6222 R&D Projects: GA ČR GA13-15390S Institutional support: RVO:67985831 Keywords : Ni-Cu-(PGE) * Lusatia * Re-Os * Bohemian Massif * sulphur Subject RIV: DD - Geochemistry Impact factor: 1.326, year: 2015

High performance computing, supercomputing, náročné počítání

Czech Academy of Sciences Publication Activity Database

Okrouhlík, Miloslav

2003-01-01

Roč. 10, č. 5 (2003), s. 429-438 ISSN 1210-2717 R&D Projects: GA ČR GA101/02/0072 Institutional research plan: CEZ:AV0Z2076919 Keywords : high performance computing * vector and parallel computers * programing tools for parellelization Subject RIV: BI - Acoustics

Dalla pizza alla cura dell’uomo, le abilità di RoDyMan

Directory of Open Access Journals (Sweden)

Nunzia Bonifati

2014-12-01

Full Text Available RoDyMan, acronym for Robotic Dynamic Manipulation, is a research project funded by the European Research Council to the CREATE Consortium and carried out at PRISMA Lab in the Department of Electrical Engineering and Information Technology of the University of Naples Federico II. The goal is the development of a service robot able to manipulate elastic and soft objects, which change continuously density and shape. These robots will be used not only in manufacturing but also as an aid to elderly or disabled people, for medical and surgical use, and in other manual activities. Preparing a pizza involves an extraordinary level of manual dexterity: for this reason a pizzaiolo robot has been conceived. It is also a tribute to Naples, at the forefront of technology, robotics and automation, but especially of culture and gastronomy, of which pizza is a symbol and tradition. Creating a robot able to manipulate objects like humans is one of the most sought and difficult challenges of robotics. It means to replicate skills that are the result of human biological and cultural evolution. This goal is arduous, mainly for two issues. First, we do not have a total knowledge of human nature, but this is the condition to be able to replicate the human functions in a machine. Second, there are many technical limits to implement a bio-inspired robot, not the least those making it user-friendly and aesthetically appreciated.

Comparative study of CD4 and CD45RO T cells and CD20 B cells in cerebrospinal fluid of syphilitic meningitis and tuberculous meningitis patients.

Science.gov (United States)

Yu, Nian; Zhang, Qiao-Quan; Zhang, Kang; Xie, Yuan; Zhu, Hai-Qing; Lin, Xing-Jian; Di, Qing

2016-09-01

This study was to investigate the differences of lymphocyte in the cerebrospinal fluid (CSF) of patients with syphilis meningitis (SM) and tuberculous meningitis (TBM) for new diagnostic insights. Totally, 79 cases of SM and 45 cases of TBM were enrolled. In the CSF, the CD4, CD45RO or CD20 positive lymphocytes were detected by immunohistochemistry. The proportion of CD4 T cells in the CSF lymphocytes in patients with SM was significantly higher than that in patients with TBM (p CD4 T-cell proportion in both groups (p CD45RO T cells in CSF lymphocytes of patients with SM was less than that of patients with TBM (p CD45RO T cells was increased in the CSF of both group patients (p cells in the CSF lymphocytes was not obviously different between the two groups during every stage. In conclusion, there are strong differences of CD4 and CD45RO T-cell ratio, but not the CD20 B cells in the meningitis. CD4 and CD45RO T cells in CSF are a useful complement in differentially diagnosing SM and TBM; it contributes to further understand the pathogenesis and prognosis of SM and TBM. © 2016 APMIS. Published by John Wiley & Sons Ltd.

Assessment of shipping emissions on four ports of Portugal.

Science.gov (United States)

Nunes, R A O; Alvim-Ferraz, M C M; Martins, F G; Sousa, S I V

2017-12-01

In the last few years, ship emissions have attracted growing attention in the scientific community. The main reason is the constant increase of marine emissions over the last twenty years due to the intensification of port traffic. Thus, this study aimed to evaluate ship emissions (PM 10 , PM 2.5 , NO x , SO 2 , CO, CO 2 , N 2 O CH 4 , NMVOC, and HC) through the activity-based methodology in four of the main ports of Portugal (Leixões, Setúbal, Sines and Viana do Castelo) during 2013 and 2014. The analysis was performed according to ship types (bulk carrier, container, general cargo, passenger, Ro-Ro cargo, tanker and others) and operational modes (manoeuvring, hotelling and during cruising). Results indicated that tankers were the largest emitters in two of the four analysed ports. Regarding cruising emissions, container ships were the largest emitters. . CO 2 , NO x and SO 2 estimated emissions represented more than 95% of the cruising and in-port emissions. Results were also compared with the total national emissions reported by the Portuguese Environment Agency, and if the in-port emissions estimated in the present study would have been taken into account to these totals, emissions of NO x and SO 2 would increase 15% and 24% in 2013 and 16% and 28% in 2014. Summing up ships seem to be an important source of air pollution, mainly regarding NO x and SO 2 . Copyright © 2017 Elsevier Ltd. All rights reserved.

Removal of organic micro-pollutants (phenol, aniline and nitrobenzene) via forward osmosis (FO) process: Evaluation of FO as an alternative method to reverse osmosis (RO).

Science.gov (United States)

Cui, Yue; Liu, Xiang-Yang; Chung, Tai-Shung; Weber, Martin; Staudt, Claudia; Maletzko, Christian

2016-03-15

In this study, we have explored and compared the effectiveness of using (1) lab-fabricated forward osmosis (FO) membranes under both FO and reverse osmosis (RO) modes and (2) commercially available RO membranes under the RO mode for the removal of organic micro-pollutants. The lab-fabricated FO membranes are thin film composite (TFC) membranes consisting of a polyamide layer and a porous substrate cast from three different materials; namely, Matrimid, polyethersulfone (PESU) and sulfonated polyphenylene sulfone (sPPSU). The results show that the FO mode is superior to the RO mode in the removal of phenol, aniline and nitrobenzene from wastewater. The rejections of all three TFC membranes to all the three organic micro-pollutants under the FO processes are higher than 72% and can be even higher than 90% for aniline when a 1000 ppm aromatic aqueous solution and 1 M NaCl are employed as feeds. These performances outperform the results obtained from themselves and commercially available RO membranes under the RO mode. In addition, the rejection can be maintained even when treating a more concentrated feed solution (2000 ppm). The removal performance can be further enhanced by using a more concentrated draw solution (2 M). The water flux is almost doubled, and the rejection increment can reach up to 17%. Moreover, it was observed that annealing as a post-treatment would help compact the membrane selective layer and further enhance the separating efficiency. The obtained organic micro-pollutant rejections and water fluxes under various feasible operating conditions indicate that the FO process has potential to be a viable treatment for wastewater containing organic micro-pollutants. Copyright © 2016 Elsevier Ltd. All rights reserved.

RoHS regulated substances in mixed plastics from waste electrical and electronic equipment.

Science.gov (United States)

Wäger, Patrick A; Schluep, Mathias; Müller, Esther; Gloor, Rolf

2012-01-17

The disposal and recovery of plastics from waste electrical and electronic equipment (WEEE) are of considerable importance, both from an environmental and an economic perspective. This paper presents the results of a study investigating current concentrations of hazardous substances in mixed plastics from WEEE and their implications for an environmentally sound recovery. The study included 53 sampling campaigns for mixed plastics from WEEE. The samples were analyzed with regard to heavy metals (cadmium, chromium, mercury, and lead) and flame retardants (PentaBDE, OctaBDE, DecaBDE, DecaBB) regulated in the RoHS Directive. Besides these substances, other brominated flame retardants known to occur in electronics (HBCD, TBBPA) as well as the total bromine and phosphorus contents were considered. Results show that no mixed plastics fraction from WEEE is completely free from substances regulated in the RoHS Directive. The lowest number and average concentrations were found in flat screen monitors. The highest concentrations were found in mixed plastics from CRT monitors and TVs. Mixed plastics fractions with high average concentrations of heavy metals originate from the treatment of small household appliances (cadmium), ICT equipment (lead), and consumer equipment (lead). Mixed plastics fractions with high average concentrations of brominated flame retardants mainly originate from the treatment of small household appliances for high temperature applications (DecaBDE), CRT monitors (OctaBDE and DecaBDE) and consumer equipment (DecaBDE), in particular CRT TVs (DecaBDE). To avoid a dissipation of hazardous substances into plastics and the environment, it is recommended that mixed plastics from WEEE are subject to a strict quality management.

European Identity and European Citizenship: the Case of Missing Polis?

Czech Academy of Sciences Publication Activity Database

Šejvl, Michal

2008-01-01

Roč. 2, č. 2 (2008), s. 49-56 ISSN 1789-1035 Institutional research plan: CEZ:AV0Z70680506 Keywords : the European integration * law of citizenship * European identity Subject RIV: AG - Legal Sciences

Un numéro spécial du réseau québécois de recherche en SST

Directory of Open Access Journals (Sweden)

Geneviève Baril-Gingras

2005-04-01

Full Text Available Bonjour à vous toutes et tous, lectrices et lecteurs de PISTES, Ce numéro spécial regroupe des articles produits à la suite du colloque organisé par le Réseau de recherche en santé et en sécurité du travail du Québec, lors du congrès de l’Association francophone pour le savoir (ACFAS à Montréal, en mai 2004. Numéro spécial, tant par le nombre de contributions, que la diversité des thématiques traitées. La totalité des articles ayant été produits par des chercheurs travaillant au Québec, ce n...

[The rotationally stable screw-anchor with trochanteric stabilizing plate (RoSA/TSP) : First results in unstable trochanteric femur fractures].

Science.gov (United States)

Maier, K-J; Bücking, B; Horst, K; Andruszkow, H; Hildebrand, F; Knobe, M

2017-12-01

In unstable trochanteric fractures, the extramedullary rotationally stable screw-anchor (RoSA) combines the benefits of the load and rotational stability of the blade with the advantages of the screw (pull-out resistance, compression capability) in a single load carrier, and was designed to prevent femoral neck shortening by using an additional locked trochanteric stabilizing plate (TSP). The aim of the current prospective cohort study was the clinical evaluation of the RoSA/TSP system regarding the mechanical re-operation rate and the amount of postoperative femoral neck shortening. From September 2011 to January 2014 80 patients with unstable trochanteric fractures underwent internal extramedullary fixation with the RoSA/TSP (Königsee Implantate GmbH, Allendorf, Germany). Due to fracture stability and after induction of compression, additional long locked antitelescoping screws (AT, n = 1-4) were placed reaching the femoral head. Radiological (femoral neck shortening) and clinical re-examination of patients (n = 61) was performed 6-10 weeks and 6-10 months later. In the 61 re-examined patients (76 %) femoral neck shortening was very low with 2 mm 6-10 months after operation. Re-operations occurred in 8 % (n = 6) and in 4 % (n = 3) as prophylactic surgical intervention. Whereas one-third (4 %) of re-operations occurred due to iatrogenic surgical problems from the first operation two-thirds of patients (8 %) had a re-operation due to delay of bone union (3× nonunion, 3 planned removals of AT-screws to improve healing). The in-hospital mortality was 3 % (n = 2). The fixation of unstable trochanteric femur fractures using the RoSA/TSP in a first clinical setting led to a great primary stability, with significant advantages with regard to limited femoral neck shortening. However, the rigidity of the construct with its consequences regarding bone healing can be challenging for the surgeon. Nevertheless, in some cases of revision it could be beneficial

An Assessment of Clinical Interchangeability of TEG (R) and RoTEM (R) Thromboelastographic Variables in Cardiac Surgical Patients

NARCIS (Netherlands)

Venema, L.F.; Post, W.J.; Hendriks, H.G.D.; Huet, R.C.G.; de Wolf, J.T.W.; de Vries, A.J.

BACKGROUND: Bedside thromboelastography is increasingly used, but an assessment of the clinical interchangeability of the 2 major systems, TEG (R) (Hemoscope) and RoTEM (R) (Pentapharm), has not been performed. METHODS: We measured blood samples from 46 cardiac surgical patients after induction of

Radioprotective effect of misonidazole (Ro-07-0582) on normal canine rectum

Energy Technology Data Exchange (ETDEWEB)

Stryker, J.A.; Albert, A.; Abt, A.B.

1980-10-01

A single 1500 rad (=15 Gy) dose of 10-MeV X-rays was administered to the pelvis of 20 mongrel dogs. Ten received misonidazole (Ro-07-0582), 100 mg/kg p.o., 4 hours pre-irradiation. Serum misonidazole levels immediately pre-irradiation were 43 +- 10 ..mu..g/ml (mean +- SD). The dogs were euthanized within 3 months post-irradiation. Each rectal specimen was studied for anatomic and histologic pathology and was assigned a Pathologic Alteration Score (PAS) of 1, 2, or 3 in order of increasing severity. The PAS of the rectal specimens from the drug group was 1.6 +- 0.7, and that of the controls 2.3 +- 0.8. The PAS of the drug group was significantly lower than the control group (P = 0.008). The data suggest that misonidazole is a radioprotector for normal tissue.

Business Ethics in Third World Countries. A Romanian Representative Case: Roşia Montană

Directory of Open Access Journals (Sweden)

Iuliana Zaharia

2010-03-01

Full Text Available Roşia Montană case became representative by its complexity, considering the interaction of the economic with other social sectors on one hand, and on the other hand, considering the context of a economy on the globalization edge in a South-eastern European country 'rebuilt' after 1989 and in a permanent 'reform' of 20 years, representative by the way the economics dictates to the politics, sealing the road to sustainable disaster in an "era of sustainable development”. Edifying symbol of the times that we live at the beginning of the XXIst century, maintaing the focus on the Romanian opened wound Roşia Montană is equivalent to a live lesson about the survival or the collapse of the (human ecosystem. About the morality as a reality of another order than that of biological life and as a sine qua non condition of the humanity preservation.Note: The aggregate term Third World was challenged as misleading starting with the Cold War period, because it got various meanings depending on different points of view: 1. it was used to define during the Cold War the countries that remained non-aligned or not moving at all with either capitalism and NATO (which along with its allies represented the First World or communism and the Soviet Union (which along with its allies represented the Second World; 2. it has also a completely different definition according to human development index – the term Third World, when used today generally denotes countries that have not "developed" to the same levels as OECD countries, and which are thus in the process of "developing"; 3. in the 1980s, economist Peter Bauer offered a competing definition for the term Third World, claiming that the attachment of Third World status to a particular country was not based on any stable economic or political criteria, and was a mostly arbitrary process. The large diversity of countries that were considered to be part of the Third World, from Indonesia to Afghanistan, ranged

Detection of a westward hotspot offset in the atmosphere of hot gas giant CoRoT-2b

Science.gov (United States)

Dang, Lisa; Cowan, Nicolas B.; Schwartz, Joel C.; Rauscher, Emily; Zhang, Michael; Knutson, Heather A.; Line, Michael; Dobbs-Dixon, Ian; Deming, Drake; Sundararajan, Sudarsan; Fortney, Jonathan J.; Zhao, Ming

2018-03-01

Short-period planets exhibit day-night temperature contrasts of hundreds to thousands of kelvin. They also exhibit eastward hotspot offsets whereby the hottest region on the planet is east of the substellar point1; this has been widely interpreted as advection of heat due to eastward winds2. We present thermal phase observations of the hot Jupiter CoRoT-2b obtained with the Infrared Array Camera (IRAC) on the Spitzer Space Telescope. These measurements show the most robust detection to date of a westward hotspot offset of 23 ± 4°, in contrast with the nine other planets with equivalent measurements3-10. The peculiar infrared flux map of CoRoT-2b may result from westward winds due to non-synchronous rotation11 or magnetic effects12,13, or partial cloud coverage, that obscure the emergent flux from the planet's eastern hemisphere14-17. Non-synchronous rotation and magnetic effects may also explain the planet's anomalously large radius12,18. On the other hand, partial cloud coverage could explain the featureless dayside emission spectrum of the planet19,20. If CoRoT-2b is not tidally locked, then it means that our understanding of star-planet tidal interaction is incomplete. If the westward offset is due to magnetic effects, our result represents an opportunity to study an exoplanet's magnetic field. If it has eastern clouds, then it means that a greater understanding of large-scale circulation on tidally locked planets is required.

The implications of the new sulphur limits on the European Ro-Ro sector

DEFF Research Database (Denmark)

Zis, Thalis; Psaraftis, Harilaos N.

2017-01-01

In an effort to reduce the environmental impacts of maritime transportation, the International Maritime Organization (IMO) designated special Sulphur Emission Control Areas (SECAs) where ships are required to use low-sulphur fuel. In January 2015, the sulphur limit within SECAs was lowered to 0...... and the redistribution of transport. Recommendations to mitigate and reverse the negative side-effects of such environmental legislation are proposed....... analyses on market share data, cargo values, freight rates, and haulers rates are conducted. Emissions inventories are constructed to assess the environmental efficacy of the SECA regulation. The novelty of the proposed model lies in the examination of the ex-post implications of shutting down a service...

Proteomics study of extracellular fibrinolytic proteases from Bacillus licheniformis RO3 and Bacillus pumilus 2.g isolated from Indonesian fermented food

Science.gov (United States)

Nur Afifah, Diana; Rustanti, Ninik; Anjani, Gemala; Syah, Dahrul; Yanti; Suhartono, Maggy T.

2017-02-01

This paper presents the proteomics study which includes separation, identification and characterization of proteins. The experiment on Indonesian fermented food such as extracellular fibrinolytic protease from Bacillus licheniformis RO3 and Bacillus pumilus 2.g isolated from red oncom and tempeh gembus was conducted. The experimental works comprise the following steps: (1) a combination of one- and two-dimensional electrophoresis analysis, (2) mass spectrometry analysis using MALDI-TOF-MS and (3) investigation using protein database. The result suggested that there were new two protein fractions of B. licheniformis RO3 and three protein fractions of B. pumilus 2.g. These result has not been previously reported.

Future Energy Benchmark for Desalination: is it Better to have a Power (electricity) Plant with ro or Med/msf?

Science.gov (United States)

Shahzad, Muhammad Wakil; Ng, Kim Choon; Thu, Kyaw

2016-06-01

Power and desalination cogeneration plants are common in many water scared courtiers. Designers and planners for cogeneration face tough challenges in deciding the options:- Is it better to operate a power plant (PP) with the reverse osmosis (i.e., PP+RO) or the thermally-driven multi-effect distillation/multi-stage flashed (PP+MED/MSF) methods. From literature, the RO methods are known to be energy efficient whilst the MED/MSF are known to have excellent thermodynamic synergies as only low pressure and temperature steam are used. Not with-standing the challenges of severe feed seawater of the Gulf, such as the frequent harmful algae blooms (HABs) and high silt contents, this presentation presents a quantitative analyses using the exergy and energetic approaches in evaluating the performances of a real cogeneration plant that was recently proposed in the eastern part of Saudi Arabia. We demonstrate that the process choice of PP+RO versus PP+MED depends on the inherent efficiencies of individual process method which is closely related to innovative process design. In this connection, a method of primary fuel cost apportionment for a co-generation plant with a MED desalination is presented. We show that an energy approach, that captures the quality of expanding steam, is a better method over the conventional work output (energetic) and the energy method seems to be over-penalizing a thermally-driven MED by as much as 22% in the operating cost of water.

Future Energy Benchmark for Desalination: Is it Better to have a Power (Electricity) Plant With RO or MED/MSF?

KAUST Repository

Shahzad, Muhammad Wakil; Ng, Kim Choon; Thu, Kyaw

2016-01-01

Power and desalination cogeneration plants are common in many water scared courtiers. Designers and planners for cogeneration face tough challenges in deciding the options:- Is it better to operate a power plant (PP) with the reverse osmosis (i.e., PP+RO) or the thermally-driven multi-effect distillation/multi-stage flashed ( PP+MED/MSF) methods. From literature, the RO methods are known to be energy efficient whilst the MED/MSF are known to have excellent thermodynamic synergies as only low pressure and temperature steam are used. Not with-standing the challenges of severe feed seawater of the Gulf, such as the frequent harmful algae blooms (HABs) and high silt contents, this presentation presents a quantitative analyses using the exergy and energetic approaches in evaluating the performances of a real cogeneration plant that was recently proposed in the eastern part of Saudi Arabia. We demonstrate that the process choice of PP+RO versus PP+MED depends on the inherent efficiencies of individual process method which is closely related to innovative process design. In this connection, a method of primary fuel cost apportionment for a co-generation plant with a MED desalination is presented. We show that an energy approach, that captures the quality of expanding steam, is a better method over the conventional work output (energetic) and the energy method seems to be over-penalizing a thermally-driven MED by as much as 22% in the operating cost of water.

Future Energy Benchmark for Desalination: Is it Better to have a Power (Electricity) Plant With RO or MED/MSF?

KAUST Repository

Shahzad, Muhammad Wakil

2016-06-23

Power and desalination cogeneration plants are common in many water scared courtiers. Designers and planners for cogeneration face tough challenges in deciding the options:- Is it better to operate a power plant (PP) with the reverse osmosis (i.e., PP+RO) or the thermally-driven multi-effect distillation/multi-stage flashed ( PP+MED/MSF) methods. From literature, the RO methods are known to be energy efficient whilst the MED/MSF are known to have excellent thermodynamic synergies as only low pressure and temperature steam are used. Not with-standing the challenges of severe feed seawater of the Gulf, such as the frequent harmful algae blooms (HABs) and high silt contents, this presentation presents a quantitative analyses using the exergy and energetic approaches in evaluating the performances of a real cogeneration plant that was recently proposed in the eastern part of Saudi Arabia. We demonstrate that the process choice of PP+RO versus PP+MED depends on the inherent efficiencies of individual process method which is closely related to innovative process design. In this connection, a method of primary fuel cost apportionment for a co-generation plant with a MED desalination is presented. We show that an energy approach, that captures the quality of expanding steam, is a better method over the conventional work output (energetic) and the energy method seems to be over-penalizing a thermally-driven MED by as much as 22% in the operating cost of water.

Hydrogen management in the MiRO refinery

Energy Technology Data Exchange (ETDEWEB)

Neumann, G. [Mineraloelraffinerie Oberrhein GmbH und Co. KG, Karlsruhe (Germany)

2010-12-30

The importance of hydrogen in refineries has increased over the last 20 years as new regulations affecting gasoline and diesel composition have been implemented throughout Europe and in an environment of increasingly stringent clean fuel regulations, decreasing heavy fuel oil demand and increasing heavy more sour crude supply. In Germany, the introduction of sulphur free gasoline and diesel with less than 10ppm sulphur(Auto Oil Program) and light home fuel oil with less than 50ppm this year were the last link in a long chain of environmental regulations, which had a considerable effect on the hydrogen demand in refineries. In the complex MiRO-refinery with a large FCC- and Coker-Unit for atmospheric residue conversion and a total throughput of more than 15 Mio.T/ a and more than 14 Mio.T/a crude oils of different origin from high sulphur, bituminous crudes to medium, low sulphur crudes for calcinate-production from green coke the only source of hydrogen for a long time was catalytic reforming. The only chance of balancing the hydrogen production and consumption was to improve the existing catalytic reforming and the optimisation of hydrogen recovery from waste or purge streams and the hydrogen network of the refinery. In 2007 a new hydrogen plant via steam reforming of natural gas went on stream. The main reason for this step was the shrinking market for gasoline in the last ten years and the blending of bio-ethanol into the gasoline pool, which released reforming capacities and the demand for octane. Another important issue is the production planning taking into account the potentials of hydrogen production via catalytic and steam reforming and the hydrogen consumption via desulphurisation and the saturation of olefins and (poly-)aromatics of the main product streams, gasoline, diesel and light home fuel oil. (orig.)

Behavior of ro-vibrationally excited H2 molecules and H atoms in a plasma expansion

International Nuclear Information System (INIS)

Vankan, P.; Schram, D.C.; Engeln, R.

2005-01-01

The behavior in a supersonic plasma expansion of H atom and H2 molecules, both ground-state and ro-vibrationally excited, is studied using various laser spectroscopic techniques. The ground-state H2 molecules expand like a normal gas. The behavior of H atoms and H 2 rv molecules, on the other hand, is considerably influenced, and to some extend even determined, by their reactivity. The H atoms diffuse out of the expansion due to surface association at the walls of the vacuum vessel. Moreover, by reducing the surface area of the nozzle by a factor of two, the amount of H atoms leaving the source is increased by one order of magnitude, due to a decreased surface association of H atoms in the nozzle. The evolution of the ro-vibrational distributions along the expansion axis shows the relaxation of the molecular hydrogen from the high temperature in the up-stream region to the low ambient temperature in the down-stream region. Whereas the vibrational distribution resembles a Boltzmann distribution, the rotational distribution is a non-equilibrium one, in which the high rotational levels (J > 7) are much more populated than what is expected from the low rotational levels (J <5). We observed overpopulations of up to seven orders of magnitude. The production of the high rotational levels is very probably connected to the surface association in the nozzle

Performances of nano filtration (NF) and reverse osmosis (RO) in textile industry waste water treatment

International Nuclear Information System (INIS)

Ellouze, E.; Souissi, S.; Ben Amar, R.; Ben Salah, A.; Jrad, A.

2009-01-01

Textile industry process (dyeing, bleaching, printing and finishing) require a high-water consumption generating high amounts of water. Reactive dyeing of 1Kg of cotton requires about 150 Litres of water and 40g reactive dye resulting in a large volume of strongly coloured effluents. This fact in combination with the current water scarcity makes necessary textile waste water reuse. In this paper experimental results obtained from the treatment by different membranes Micro filtration (MF), Nano filtration (NF) and Reverse Osmosis (RO) of Sitex industry waste water pretreated by biological activated sludge are presented and compared. The results obtained from direct Nano filtration performed at different transmembrane pressures (8 - 1 m - 2 for a Volumetric Concentration Factor (VCF) of 4 and that the osmotic pressure π= 4Bars. A high quality of treated effluent in term of colour removal and desalination was obtained for a VCF of 2: salinity retention rate (RR) 57 pour cent and discoloration almost 100 pour cent at pressure of 12 bar. While, the permeate flux obtained using the combination MF/RO at a different pressures 25 - 1 m- 2 for a VCF of 6 indicating an important fouling. In this case, the osmotic pressure varied from 6 to 28 bars. The optimum salinity and colour retention rate (RR) were 86 pour cent and 100 pour cent respectively obtained at a VCF of 2.

Tent Preservation Project - Demonstration/Validation for Replacement of Aqueous Copper 8 Quinolinolate Treatment of Cotton Webbing With RO-59-WP

National Research Council Canada - National Science Library

Bosselman, Suzanne E

2008-01-01

.... This report describes a demonstration/validation study of an alternative coating, RO-59-WP, as a potential additive to or replacement for Copper 8, which has been taken off the market several times...

Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole)

International Nuclear Information System (INIS)

Newman, H.F.; Bleehen, N.M.; Ward, R.; Workman, P.

1988-01-01

The hypoxic cell radiosensitizers Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole) have been evaluated for their simultaneous penetration into human brain tumors and surrounding normal tissue. Thirteen patients received a dose of 1 g of each agent, infused over a 10 minute period during neurosurgery. Samples of glioma (20), brain (10) and cerebrospinal fluid (1) were obtained at a mean time (+/- SD) of 31 +/- 18 min from the end of infusion. A 24 hr plasma time course was measured in six patients. Nitroimidazole concentrations were determined by HPLC. For a mean dose of 0.55 g/m2 of each agent, the mean tumor concentrations (+/- SD) were 17.0 +/- 12.0 micrograms/g for Ro 03-8799 and 13.5 +/- 10.9 micrograms/g for SR 2508. The tumor/plasma ratios were 279 +/- 230% and 47 +/- 34% respectively. For adjacent 'normal' brain tissue, the radiosensitizer concentrations were 29.9 +/- 13.1 micrograms/g for Ro 03-8799, and 4.0 +/- 1.7 micrograms/g for SR 2508, and the brain/plasma ratios were 430 +/- 29% and 14 +/- 8% respectively. There was a significant trend towards increasing accumulation of both agents with time, in both tumor and normal brain. Concentrations in cerebrospinal fluid were very low. Plasma pharmacokinetics for Ro 03-8799 were similar to previous experience, but for SR 2508 the terminal half-life was greater in this series by a factor of 1.3. The results confirm that Ro 03-8799 is distributed widely in the central nervous system, and demonstrate that SR 2508 can achieve high tumor concentrations when the blood-brain barrier is compromised. The concentrations achieved with the combination are indicative of a significant advantage over metronidazole, misonidazole, or either agent alone, and normalized to the therapeutic dose of 0.75 g/m2 plus 2.0 g/m2 SR 2508 are consistent with those giving additive sensitization in an in vivo mouse tumor model

A framework for risk assessment for maritime transportation systems—A case study for open sea collisions involving RoPax vessels

International Nuclear Information System (INIS)

Montewka, Jakub; Ehlers, Sören; Goerlandt, Floris; Hinz, Tomasz; Tabri, Kristjan; Kujala, Pentti

2014-01-01

Maritime accidents involving ships carrying passengers may pose a high risk with respect to human casualties. For effective risk mitigation, an insight into the process of risk escalation is needed. This requires a proactive approach when it comes to risk modelling for maritime transportation systems. Most of the existing models are based on historical data on maritime accidents, and thus they can be considered reactive instead of proactive. This paper introduces a systematic, transferable and proactive framework estimating the risk for maritime transportation systems, meeting the requirements stemming from the adopted formal definition of risk. The framework focuses on ship–ship collisions in the open sea, with a RoRo/Passenger ship (RoPax) being considered as the struck ship. First, it covers an identification of the events that follow a collision between two ships in the open sea, and, second, it evaluates the probabilities of these events, concluding by determining the severity of a collision. The risk framework is developed with the use of Bayesian Belief Networks and utilizes a set of analytical methods for the estimation of the risk model parameters. Finally, a case study is presented, in which the risk framework developed here is applied to a maritime transportation system operating in the Gulf of Finland (GoF). The results obtained are compared to the historical data and available models, in which a RoPax was involved in a collision, and good agreement with the available records is found. - Highlights: • A framework for risk analysis and assessment in maritime transportation systems following the formal requirements adopted is presented here. • A Bayesian Belief Network is used, allowing instantaneous propagation of knowledge through the framework. • The uncertainties of the input variables are quantified. • A contribution to a holistic risk model for a selected maritime activity is made. • A set of analytical methods is used to estimate risk

Chemical composition and evolution of tourmaline-supergroup minerals from the Sb hydrothermal veins in Rožňava area, Western Carpathians, Slovakia

Science.gov (United States)

Bačík, Peter; Dikej, Jakub; Fridrichová, Jana; Miglierini, Marcel; Števko, Martin

2017-09-01

Tourmaline-supergroup minerals are common gangue minerals in Sb-hydrothermal veins on Betliar - Straková, Čučma - Gabriela and Rožňava - Peter-Pavol vein deposits in the Rožňava area, Slovakia. Tourmaline-supergroup minerals form relatively large prismatic to radial aggregates of parallel black to greyish-black crystals. Tourmaline-supergroup minerals from Betliar - Straková and Rožňava - Peter-Pavol are almost homogeneous with intermediate schorl-dravite composition. Čučma - Gabriela tourmaline have distinct zoning with massive core of the schorlitic-to-feruvitic shifting to schorlitic-to-dravitic composition, and dravitic to magnesio-foititic rim. The tourmaline composition is influenced by two main substitutions, namely Ca(Mg,Fe)Na-1Al-1 and X □AlNa-1(Mg,Fe)-1. Betliar - Straková and Rožňava - Peter-Pavol tourmaline-supergroup minerals exhibit only small extents of the X □AlNa-1(Mg,Fe)-1 substitution. This substitution shifts the composition to magnesio-foitite in Čučma - Gabriela tourmaline. The decrease of Al in the core of Čučma - Gabriela tourmaline crystals is caused by extensive Ca(Mg,Fe)Na-1Al-1 substitution. The unit-cell dimensions of all investigated tourmaline-supergroup minerals indicate an octahedral disorder with the Z (Fe3++Mg) proportion calculated from empirical equations varying between 0.85 and 0.87 apfu (atoms per formula unit). Based on Mössbauer spectra, the Z Fe3+ content varied between 0.25 apfu in Betliar - Straková tourmaline and 0.45 apfu in Čučma - Gabriela sample. Based on Fe/(Fe + Mg) ratio, Betliar - Straková tourmaline is slightly enriched in Fe compared to Rožňava - Peter-Pavol, suggesting the impact of the host-rock composition; first are grown in Fe-richer acidic metarhyolitic rocks, latter in metapelites. In Čučma - Gabriela, the variations in Fe/(Fe + Mg) are very likely reflecting the change in fluid composition. Magnesio-foitite is the product of second-stage crystallization forming rims and

Early non-destructive biofouling detection in spiral wound RO Membranes using a mobile earth's field NMR

KAUST Repository

Fridjonsson, E.O.; Vogt, S.J.; Vrouwenvelder, Johannes S.; Johns, M.L.

2015-01-01

We demonstrate the use of Earth's field (EF) Nuclear Magnetic Resonance (NMR) to provide early non-destructive detection of active biofouling of a commercial spiral wound reverse osmosis (RO) membrane module. The RO membrane module was actively biofouled to different extents, by the addition of biodegradable nutrients to the feed stream, as revealed by a subtle feed-channel pressure drop increase. Easily accessible EF NMR parameters (signal relaxation parameters T1, T2 and the total NMR signal modified to be sensitive to stagnant fluid only) were measured and analysed in terms of their ability to detect the onset of biofouling. The EF NMR showed that fouling near the membrane module entrance significantly distorted the flow field through the whole membrane module. The total NMR signal is shown to be suitable for non-destructive early biofouling detection of spiral wound membrane modules, it was readily deployed at high (operational) flow rates, was particularly sensitive to flow field changes due to biofouling and could be deployed at any position along the membrane module axis. In addition to providing early fouling detection, the mobile EF NMR apparatus could also be used to (i) evaluate the production process of spiral wound membrane modules, and (ii) provide an in-situ determination of module cleaning process efficiency.

Early non-destructive biofouling detection in spiral wound RO Membranes using a mobile earth's field NMR

KAUST Repository

Fridjonsson, E.O.

2015-04-20

We demonstrate the use of Earth\\'s field (EF) Nuclear Magnetic Resonance (NMR) to provide early non-destructive detection of active biofouling of a commercial spiral wound reverse osmosis (RO) membrane module. The RO membrane module was actively biofouled to different extents, by the addition of biodegradable nutrients to the feed stream, as revealed by a subtle feed-channel pressure drop increase. Easily accessible EF NMR parameters (signal relaxation parameters T1, T2 and the total NMR signal modified to be sensitive to stagnant fluid only) were measured and analysed in terms of their ability to detect the onset of biofouling. The EF NMR showed that fouling near the membrane module entrance significantly distorted the flow field through the whole membrane module. The total NMR signal is shown to be suitable for non-destructive early biofouling detection of spiral wound membrane modules, it was readily deployed at high (operational) flow rates, was particularly sensitive to flow field changes due to biofouling and could be deployed at any position along the membrane module axis. In addition to providing early fouling detection, the mobile EF NMR apparatus could also be used to (i) evaluate the production process of spiral wound membrane modules, and (ii) provide an in-situ determination of module cleaning process efficiency.

A class of singular Ro-matrices and extensions to semidefinite linear complementarity problems

Directory of Open Access Journals (Sweden)

Sivakumar K.C.

2013-01-01

Full Text Available For ARnxn and qRn, the linear complementarity problem LCP(A, q is to determine if there is xRn such that x ≥ 0; y = Ax + q ≥ 0 and xT y = 0. Such an x is called a solution of LCP(A,q. A is called an Ro-matrix if LCP(A,0 has zero as the only solution. In this article, the class of R0-matrices is extended to include typically singular matrices, by requiring in addition that the solution x above belongs to a subspace of Rn. This idea is then extended to semidefinite linear complementarity problems, where a characterization is presented for the multplicative transformation.

Littérature et sciences sociales dans l’espace romand, à propos d’un numéro de la revue A Contrario

OpenAIRE

Provenzano, François

2007-01-01

La belle revue A Contrario consacre son dernier numéro (disponible en ligne) aux croisements variés entre la littérature et les sciences sociales, en particulier dans l’espace romand. Il ne s’agit pas, au fil de la dizaine de contributions qui constituent le dossier, de dégager un modèle théorique unique qui permettrait de penser l’articulation entre ces deux champs de connaissance. L’intérêt de ce numéro spécial tient précisément au fait qu’il propose une très riche variété de points de vue ...

Fundamental properties of stars using asteroseismology from Kepler and CoRoT and interferometry from the CHARA Array

DEFF Research Database (Denmark)

Huber, D.; Ireland, M.J.; Bedding, T.R.

2012-01-01

We present results of a long-baseline interferometry campaign using the PAVO beam combiner at the CHARA Array to measure the angular sizes of five main-sequence stars, one subgiant and four red giant stars for which solar-like oscillations have been detected by either Kepler or CoRoT. By combinin...

A Compact and Low Power RO PUF with High Resilience to the EM Side-Channel Attack and the SVM Modelling Attack of Wireless Sensor Networks.

Science.gov (United States)

Cao, Yuan; Zhao, Xiaojin; Ye, Wenbin; Han, Qingbang; Pan, Xiaofang

2018-01-23

Authentication is a crucial security service for the wireless sensor networks (WSNs) in versatile domains. The deployment of WSN devices in the untrusted open environment and the resource-constrained nature make the on-chip authentication an open challenge. The strong physical unclonable function (PUF) came in handy as light-weight authentication security primitive. In this paper, we present the first ring oscillator (RO) based strong physical unclonable function (PUF) with high resilience to both the electromagnetic (EM) side-channel attack and the support vector machine (SVM) modelling attack. By employing an RO based PUF architecture with the current starved inverter as the delay cell, the oscillation power is significantly reduced to minimize the emitted EM signal, leading to greatly enhanced immunity to the EM side-channel analysis attack. In addition, featuring superior reconfigurability due to the conspicuously simplified circuitries, the proposed implementation is capable of withstanding the SVM modelling attack by generating and comparing a large number of RO frequency pairs. The reported experimental results validate the prototype of a 9-stage RO PUF fabricated using standard 65 nm complementary-metal-oxide-semiconductor (CMOS) process. Operating at the supply voltage of 1.2 V and the frequency of 100 KHz, the fabricated RO PUF occupies a compact silicon area of 250 μ m 2 and consumes a power as low as 5.16 μ W per challenge-response pair (CRP). Furthermore, the uniqueness and the worst-case reliability are measured to be 50.17% and 98.30% for the working temperature range of -40∼120 ∘ C and the supply voltage variation of ±2%, respectively. Thus, the proposed PUF is applicable for the low power, low cost and secure WSN communications.

77 FR 1707 - National Toxicology Program (NTP) Final Process for Preparation of the Report on Carcinogens (RoC)

Science.gov (United States)

2012-01-11

... the RoC. The process is available on the NTP Web site ( http://ntp.niehs.nih.gov/go/rocprocess ) or by... Counselors public meeting (76 FR 68461) on December 15, 2011 ( http://ntp.niehs.nih.gov/go/9741 ). The NTP... Web site ( http://ntp.niehs.nih.gov/go/rocprocess ) or by contacting Dr. Lunn (see ADDRESSES...

RoBlock: a prototype autonomous manufacturing cell

Science.gov (United States)

Baekdal, Lars K.; Balslev, Ivar; Eriksen, Rene D.; Jensen, Soren P.; Jorgensen, Bo N.; Kirstein, Brian; Kristensen, Bent B.; Olsen, Martin M.; Perram, John W.; Petersen, Henrik G.; Petersen, Morten L.; Ruhoff, Peter T.; Skjolstrup, Carl E.; Sorensen, Anders S.; Wagenaar, Jeroen M.

2000-10-01

RoBlock is the first phase of an internally financed project at the Institute aimed at building a system in which two industrial robots suspended from a gantry, as shown below, cooperate to perform a task specified by an external user, in this case, assembling an unstructured collection of colored wooden blocks into a specified 3D pattern. The blocks are identified and localized using computer vision and grasped with a suction cup mechanism. Future phases of the project will involve other processes such as grasping and lifting, as well as other types of robot such as autonomous vehicles or variable geometry trusses. Innovative features of the control software system include: The use of an advanced trajectory planning system which ensures collision avoidance based on a generalization of the method of artificial potential fields, the use of a generic model-based controller which learns the values of parameters, including static and kinetic friction, of a detailed mechanical model of itself by comparing actual with planned movements, the use of fast, flexible, and robust pattern recognition and 3D-interpretation strategies, integration of trajectory planning and control with the sensor systems in a distributed Java application running on a network of PC's attached to the individual physical components. In designing this first stage, the aim was to build in the minimum complexity necessary to make the system non-trivially autonomous and to minimize the technological risks. The aims of this project, which is planned to be operational during 2000, are as follows: To provide a platform for carrying out experimental research in multi-agent systems and autonomous manufacturing systems, to test the interdisciplinary cooperation architecture of the Maersk Institute, in which researchers in the fields of applied mathematics (modeling the physical world), software engineering (modeling the system) and sensor/actuator technology (relating the virtual and real worlds) could

Aknu steatozes radioloģiskās ainas korelācija ar lipīdu frakcijām un koronāro artēriju kalcinozi

OpenAIRE

Pavlovičs, Sergejs

2016-01-01

Tika izpētīti 140 pacientu datortomogrāfijas attēli, kuros tika izvērtēti aknu steatozes un koronāro artēriju kalcinozes klātbūtne. Mēŗkis ir noskaidrot abu slimību prevalenci starp dzimumiem un vecuma grupās, kā arī slimību savstarpējo saistību un saistību ar lipīdu frakciju izmaiņām, blakusslimībām un aknu bojājuma marķieriem. Aknu steatoze un koronāro artēriju kalcinoze biežāk vērojama vīriešiem vecuma grupā ≥50 gadu vecuma. Ir vērojama lielāka koronāro artēriju kalcinozes prevalence pacie...

Modulation of natural IgM autoantibodies to oxidative stress-related neo-epitopes on apoptotic cells in newborns of mothers with anti-Ro autoimmunity.

Science.gov (United States)

Grönwall, Caroline; Clancy, Robert M; Getu, Lelise; Lloyd, Katy A; Siegel, Don L; Reed, Joanne H; Buyon, Jill P; Silverman, Gregg J

2016-09-01

At birth, the human immune system already contains substantial levels of polymeric IgM, that include autoantibodies to neo-epitopes on apoptotic cells (ACs) that are proposed to play homeostatic and anti-inflammatory roles. Yet the biologic origins and developmental regulation of these naturally arising antibodies remain poorly understood. Herein, we report that levels of IgM-antibodies to malondialdehyde (MDA) protein adducts, a common type of in vivo generated oxidative stress-related neoepitope, directly correlate with the relative binding of neonatal-IgM to ACs. Levels of IgM to phosphorylcholine (PC), a natural antibody prevalent in adults, were relatively scant in cord blood, while there was significantly greater relative representation of IgM anti-MDA antibodies in newborns compared to adults. To investigate the potential interrelationships between neonatal IgM with pathogenic IgG-autoantibodies, we studied 103 newborns born to autoimmune mothers with IgG anti-Ro (i.e., 70 with neonatal lupus and 33 without neonatal lupus). In these subjects the mean levels of IgM anti-Ro60 were significantly higher than in the newborns from non-autoimmune mothers. In contrast, levels of IgM anti-MDA in IgG anti-Ro exposed neonates were significantly lower than in neonates from non-autoimmune mothers. The presence or absence of neonatal lupus did not appear to influence the total levels of IgM in the anti-Ro exposed newborns. Taken together, our studies provide evidence that the immune development of the natural IgM-repertoire may be affected, and become imprinted by, the transfer of maternal IgG into the fetus. Copyright © 2016 Elsevier Ltd. All rights reserved.

Effects of the benzodiazepine antagonists RO 15-1788, CGS-8216 and PK-11195 on amygdaloid kindled seizures and the anticonvulsant efficacy of diazepam.

Science.gov (United States)

Albertson, T E; Walby, W F

1986-11-01

The anticonvulsant effectiveness of the benzodiazepine antagonists RO 15-1788, CGS-8216 and PK-11195 were evaluated against threshold and suprathreshold (400 microA) stimulation in fully amygdaloid-kindled rats. Pretreatment with either RO 15-1788 (3, 10 and 30 mg/kg), CGS-8216 (3, 10 and 30 mg/kg) or PK-11195 (10 and 60 mg/kg) failed in this study to modify consistently either the afterdischarge thresholds or elicited suprathreshold seizures or duration of afterdischarge. Using a double injection paradigm, the effectiveness of these three benzodiazepine antagonists to reverse the anti-convulsant and behavioral effects of diazepam were studied. When diazepam (3 mg/kg) was injected 15 min before or after a second injection of the vehicle control DMSO (0.25 ml/kg), a significant reduction in the duration of afterdischarge and seizure rank, elicited by a suprathreshold stimulation in amygdaloid-kindled rats, occurred. When either CGS 8216 (10 mg/kg) or RO 15-1788 (10 mg/kg) were given 15 min before diazepam (3 mg/kg) prior to stimulation, the anticonvulsant properties of diazepam were blocked. When RO 15-1788 (10 mg/kg) was given 15 min after diazepam, antagonism of the anticonvulsant effects on diazepam was shown. However, when either CGS-8216 (10 mg/kg) or PK-11195 (10 and 60 mg/kg) were given 15 min after diazepam (3 mg/kg), the anticonvulsant properties of diazepam were not blocked. The anticonvulsant effects of diazepam were reversed when CGS-8216 (10 mg/kg) was given 5 min after diazepam (3 mg/kg) or when a larger dose (30 mg/kg) was given at the same 15 min interval.(ABSTRACT TRUNCATED AT 250 WORDS)

Effects of RO 15-1788 on a running response rewarded on continuous or partial reinforcement schedules.

Science.gov (United States)

Hawkins, M; Sinden, J; Martin, I; Gray, J A

1988-01-01

Two experiments were run in which rats were rewarded with food for running in a straight alley at one trial a day, followed by extinction of the running response. During acquisition of the response, reward was delivered either on a continuous reinforcement (CRF) or on a quasirandom 50% partial reinforcement (PRF) schedule. The groups given PRF were more resistant to extinction than those given CRF, the well-known partial reinforcement extinction effect. In Experiment 1 different groups of rats were injected during acquisition only with 1, 5 or 10 mg/kg of the benzodiazepine antagonist, RO 15-1788, or with placebo. In Experiment 2, 5 mg/kg RO 15-1788 or placebo were administered in a full cross-over design during acquisition, extinction or both. At the end of Experiment 2 only [3H]-flunitrazepam binding was measured in either the presence or absence of added gamma-aminobutyrate (GABA) in homogenates of hippocampi dissected from the animals that had received behavioural training. The drug affected running speeds during both acquisition and extinction in different ways depending upon the schedule of reinforcement (CRF or PRF) and also gave rise to enhanced GABA stimulation of [3H]-flunitrazepam binding. The results are discussed in relation to the hypothesis that the neurochemical pathways by which reinforcement schedules modify behaviour include a step influenced by benzodiazepine receptors.

Exergy Analysis of a Two-Pass Reverse Osmosis (RO Desalination Unit with and without an Energy Recovery Turbine (ERT and Pressure Exchanger (PX

Directory of Open Access Journals (Sweden)

Nuri M. Eshoul

2015-07-01

Full Text Available This paper presents an exergy analysis of an actual two-pass (RO desalination system with the seawater solution treated as a real mixture and not an ideal mixture. The actual 127 ton/h two pass RO desalination plant was modeled using IPSEpro software and validated against operating data. The results show that using the (ERT and (PX reduced the total power consumption of the SWRO desalination by about 30% and 50% respectively, whereas, the specific power consumption for the SWRO per m3 water decreased from 7.2 kW/m3 to 5.0 kW/m3 with (ERT and 3.6 kW/m3 with (PX. In addition, the exergy efficiency of the RO desalination improved by 49% with ERT and 77% with PX and exergy destruction was reduced by 40% for (ERT and 53% for (PX. The results also showed that, when the (ERT and (PX were not in use, accounted for 42% of the total exergy destruction. Whereas, when (ERT and (PX are in use, the rejected seawater account maximum is 0.64%. Moreover, the (PX involved the smallest area and highest minimum separation work.

Cellular reactions of CD3+ CD4+ CD45RO+ T-lymphocytes on dexamethason in in normal patients and in patients with with rheumatoid arthritis in vitro

Directory of Open Access Journals (Sweden)

L. S. Litvinova

2017-01-01

Full Text Available The aim of the study was to analyze the influence of glucocorticoid (GC dexamethasone (Dex on changes in CD4+ T-cells expressing the surface molecule of activation (CD25, CD71, HLA-DR and CD95 and their ability to produce proinflammatory mediators in cultures of TCR-stimulated CD3+CD45RO+ T-lymphocytes obtained from healthy donors and patients with rheumatoid arthritis in vitro.Materials and methods. The study included 50 patients and 20 healthy donors. T-cell cultures (CD3+ CD45RO+ were obtained from mononuclear leukocytes of immunomagnetic separation (MACS® technology. As an activator of T-lymphocytes, antibiotic particles with biotinylated antibodies against CD2+, CD3+, CD28+, which simulate the process of costimulation of T cells by antigen-presenting cells, were used. The following concentrations of dexamethasone (2, 8, 16, 32, 64 mg were used in the experiment. The change in the immunophenotype of T-lymphocytes was analyzed by flow cytofluoometry. The secretion of CD3+CD45RO+ T-cells of proinflammatory cytokines IL-2, IFNγ, TNFα, IL-17 and IL-21 was evaluated by enzyme-linked immunosorbent assay.Results. The general suppressor effect of Dex on CD3+CD45RO+ T-cell cultures mediated by a decrease in the number of CD4 + T cells expressing activation molecules (CD25 and proliferation (CD71, as well as inhibition of the production of inflammatory mediators: IFNγ, IL-2 and TNFα. It is shown that against the background of TCR activation Dex increases the number of CD4+CD95+HLA-DR+ cells in CD3+CD45RO+ cultures obtained from RA patients and does not change their content in the control. The correlations between the number of proinflammatory factors (IL-17, IL-21 and TNFα in CD4+CD45RO+CD95+HLA-DR+ T cells in supernatants of cell cultures in RA patients indicate the presence of a pro-inflammatory potential of this population of T cells. We assume that the resistance of CD4+CD45RO+CD95+HLA-DR+ T cells in RA patients to the suppressor effect of

How different is the composition of the fouling layer of wastewater reuse and seawater desalination RO membranes?

KAUST Repository

Khan, Muhammad; Busch, Markus; Molina, Veró nica Garcí a; Emwas, Abdul-Hamid M.; Aubry, Cyril; Croue, Jean-Philippe

2014-01-01

To study the effect of water quality and operating parameters on membrane fouling, a comparative analysis of wastewater (WW) and seawater (SW) fouled reverse osmosis (RO) membranes was conducted. Membranes were harvested from SWRO and WWRO pilot plants located in Vilaseca (East Spain), both using ultrafiltration as pretreatment. The SWRO unit was fed with Mediterranean seawater and the WWRO unit was operated using secondary effluent collected from the municipal wastewater treatment plant. Lead and terminal SWRO and WWRO modules were autopsied after five months and three months of operation, respectively. Ultrastructural, chemical, and microbiological analyses of the fouling layers were performed. Results showed that the WWRO train had mainly bio/organic fouling at the lead position element and inorganic fouling at terminal position element, whereas SWRO train had bio/organic fouling at both end position elements. In the case of WWRO membranes, Betaproteobacteria was the major colonizing species; while Ca, S, and P were the major present inorganic elements. The microbial population of SWRO membranes was mainly represented by Alpha and Gammaproteobacteria. Ca, Fe, and S were the main identified inorganic elements of the fouling layer of SWRO membranes. These results confirmed that the RO fouling layer composition is strongly impacted by the source water quality. © 2014 Elsevier Ltd.

How different is the composition of the fouling layer of wastewater reuse and seawater desalination RO membranes?

KAUST Repository

Khan, Muhammad

2014-08-01

To study the effect of water quality and operating parameters on membrane fouling, a comparative analysis of wastewater (WW) and seawater (SW) fouled reverse osmosis (RO) membranes was conducted. Membranes were harvested from SWRO and WWRO pilot plants located in Vilaseca (East Spain), both using ultrafiltration as pretreatment. The SWRO unit was fed with Mediterranean seawater and the WWRO unit was operated using secondary effluent collected from the municipal wastewater treatment plant. Lead and terminal SWRO and WWRO modules were autopsied after five months and three months of operation, respectively. Ultrastructural, chemical, and microbiological analyses of the fouling layers were performed. Results showed that the WWRO train had mainly bio/organic fouling at the lead position element and inorganic fouling at terminal position element, whereas SWRO train had bio/organic fouling at both end position elements. In the case of WWRO membranes, Betaproteobacteria was the major colonizing species; while Ca, S, and P were the major present inorganic elements. The microbial population of SWRO membranes was mainly represented by Alpha and Gammaproteobacteria. Ca, Fe, and S were the main identified inorganic elements of the fouling layer of SWRO membranes. These results confirmed that the RO fouling layer composition is strongly impacted by the source water quality. © 2014 Elsevier Ltd.

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques

KAUST Repository

Pacheco, Federico A.

2010-08-15

Achieving a better understanding of transport and rejection mechanisms in RO and NF membranes requires more detailed information of the nanostructure of polyamide thin films. This study reports on two novel transmission electron microscopy (TEM) techniques for characterizing polyamide nanostructure. The first technique produces cross-sectional images of isolated polyamide thin films by removing the polysulfone support from regular TEM cross-sections. In the second technique called " projected area" TEM (PA-TEM), isolated polyamide thin films are placed with their surface perpendicular to the electron beam. The resulting images capture the thickness, morphology and mass density of the entire thin film. In combination, these new techniques provide information on polyamide nanostructure that is not evident using conventional methods. For the commercial RO membrane ESPA3, the cross-sectional view of the isolated polyamide thin film shows a 30-60. nm thick base of nodular polyamide (presumably the separation barrier) that forms a relatively smooth interface with the polysulfone support. Above this, a more open structure of loose polyamide extends outward giving rise to the ridge-and-valley surface structure. In PA-TEM images, the ridges and valleys correspond to the dark and bright regions, respectively; the polyamide nodular base appears as round features forming an irregular honeycomb pattern throughout the images. Membrane cross-sections were prepared with a simple resin embedding protocol using the acrylic resin LR White. The protocol did not require dehydration steps, and was applicable to both dry and wet membrane samples. Artifacts that may be produced during sample preparation were also documented. © 2010 Elsevier B.V.

Characterization of isolated polyamide thin films of RO and NF membranes using novel TEM techniques

KAUST Repository

Pacheco, Federico A.; Pinnau, Ingo; Reinhard, Martin; Leckie, James O.

2010-01-01

Achieving a better understanding of transport and rejection mechanisms in RO and NF membranes requires more detailed information of the nanostructure of polyamide thin films. This study reports on two novel transmission electron microscopy (TEM) techniques for characterizing polyamide nanostructure. The first technique produces cross-sectional images of isolated polyamide thin films by removing the polysulfone support from regular TEM cross-sections. In the second technique called " projected area" TEM (PA-TEM), isolated polyamide thin films are placed with their surface perpendicular to the electron beam. The resulting images capture the thickness, morphology and mass density of the entire thin film. In combination, these new techniques provide information on polyamide nanostructure that is not evident using conventional methods. For the commercial RO membrane ESPA3, the cross-sectional view of the isolated polyamide thin film shows a 30-60. nm thick base of nodular polyamide (presumably the separation barrier) that forms a relatively smooth interface with the polysulfone support. Above this, a more open structure of loose polyamide extends outward giving rise to the ridge-and-valley surface structure. In PA-TEM images, the ridges and valleys correspond to the dark and bright regions, respectively; the polyamide nodular base appears as round features forming an irregular honeycomb pattern throughout the images. Membrane cross-sections were prepared with a simple resin embedding protocol using the acrylic resin LR White. The protocol did not require dehydration steps, and was applicable to both dry and wet membrane samples. Artifacts that may be produced during sample preparation were also documented. © 2010 Elsevier B.V.

The structurally novel Ca2+ channel blocker Ro 40-5967, which binds to the [3H] desmethoxyverapamil receptor, is devoid of the negative inotropic effects of verapamil in normal and failing rat hearts

International Nuclear Information System (INIS)

Clozel, J.P.; Veniant, M.; Osterrieder, W.

1990-01-01

Ro 40-5967 is a structurally novel Ca 2+ channel blocker that binds to the verapamil-type receptor of cardiac membranes but that has been shown in isolated guinea-pig hearts to be about ten times less potent a negative inotropic agent than verapamil. The goals of the present study were to confirm these findings in vitro in isolated perfused rat hearts as well as in vivo in conscious rats and to compare Ro 40-5967 to verapamil. The effects of Ro 40-5967 and verapamil were tested not only in normal rats, but also in rats with heart failure induced by chronic myocardial infarction. In isolated Langendorff hearts (without heart failure), no decrease of contractility was observed with Ro 40-5967 up to complete AV block. In contrast, verapamil decreased contractility with an IC50 of 100 nM. In isolated, electrically stimulated rat papillary muscles, the IC50 values for the decrease of contractile force were 15,000 and 440 nM for Ro 40-5967 and verapamil, respectively. In vivo, Ro 40-5967 did not decrease left ventricular contractility (as assessed by changes of dP/dt max +) in rats without and with heart failure. In contrast, verapamil was markedly negative inotropic in both conditions

Utilization of reverse osmosis (RO) for reuse of MBR-treated wastewater in irrigation-preliminary tests and quality analysis of product water.

Science.gov (United States)

Bunani, Samuel; Yörükoğlu, Eren; Sert, Gökhan; Kabay, Nalan; Yüksel, Ümran; Yüksel, Mithat; Egemen, Özdemir; Pek, Taylan Özgür

2018-02-01

Membrane bioreactor (MBR) effluent collected from a wastewater treatment plant installed at an industrial zone was used for reverse osmosis (RO) membrane tests in the laboratory. For this, two different GE Osmonics RO membranes (AK-BWRO and AD-SWRO) were employed. The results showed that AK-brackish water reverse osmosis (AK-BWRO) and AD-seawater reverse osmosis (AD-SWRO) membranes have almost similar rejection performances regarding analyzed parameters such as conductivity, salinity, color, chemical oxygen demand (COD), and total organic carbon (TOC). On the other hand, these membranes behaved quite differently considering their permeate water flux at the same applied pressure of 10 bar. AD-SWRO membrane was also tested at 20 bar. The results revealed that AD-SWRO membrane had almost the same rejections either at 10 or at 20 bar of applied pressure. Compared with irrigation water standards, AK-BWRO and AD-SWRO gave an effluent with low salinity value and sodium adsorption ratio (SAR) which makes it unsuitable for irrigation due to the infiltration problems risi0ng from unbalanced values of salinity and SAR. Combination of MBR effluent and RO effluent at respective proportions of 0.3:0.7 and 0.4:0.6 for AK-BWRO and AD-SWRO, respectively, are the optimum mixing ratios to overcome the infiltration hazard problem. Choice of less-sensitive crops to chloride and sodium ions is another strategy to overcome all hazards which may arise from above suggested mixing proportions.

50. Výročí Nobelovy ceny za chemii - putovní výstava "Příběh kapky"

Czech Academy of Sciences Publication Activity Database

Stejskalová, Květoslava

2009-01-01

Roč. 103, č. 11 (2009), s. 898-899 ISSN 0009-2770 R&D Projects: GA MŠk 2E08038 Institutional research plan: CEZ:AV0Z40400503 Keywords : Nobel price * traveling exhibition * Heyrovský Subject RIV: CG - Electrochemistry Impact factor: 0.717, year: 2009

Feasibility of municipal solid waste (MSW as energy sources for Saudi Arabia’s future Reverse osmosis (RO desalination plants

Directory of Open Access Journals (Sweden)

Agboola Phillips O.

2016-12-01

Full Text Available The Kingdom of Saudi Arabia (KSA generates between 1.4–1.75 kg/person/day of Municipal Solid Waste (MSW that accounts for over 16 million tons of MSW/year. The solid waste collected from different sources is dumped in landfills, thereby creating environmental concerns. In this paper, the potential of solid waste as an energy source (Waste to Energy (WTE for Reverse Osmosis (RO water purification was evaluated. The KSA is known for its acute fresh water shortages and uses desalination technology in meeting its daily water requirements; a process that is energy intensive. The evaluation of the energy content of MSW shows a potential to produce about 927 MW in 2015, based on a total mass burn, and about 1,692 MW in 2032. The MSW-WTE plants can produce about 1.5% of the targeted 120 GW of energy for 2032. For the R.O system, it will give approximately 16.8% of the daily fresh water needed for total mass burn and 2.4% with the recycling option.

Characteristics of solar-like oscillations in red giants observed in the CoRoT exoplanet field

Science.gov (United States)

Hekker, S.; Kallinger, T.; Baudin, F.; De Ridder, J.; Barban, C.; Carrier, F.; Hatzes, A. P.; Weiss, W. W.; Baglin, A.

2009-10-01

Context: Observations during the first long run (~150 days) in the exo-planet field of CoRoT increase the number of G-K giant stars for which solar-like oscillations are observed by a factor of 100. This opens the possibility to study the characteristics of their oscillations in a statistical sense. Aims: We aim to understand the statistical distribution of the frequencies of maximum oscillation power (ν_max) in red giants and to search for a possible correlation between ν_max and the large separation (Δ ν). Methods: Red giants with detectable solar-like oscillations are identified using both semi-automatic and manual procedures. For these stars, we determine ν_max as the centre of a Gaussian fit to the oscillation power excess. For the determination of Δ ν, we use the autocorrelation of the Fourier spectra, the comb response function and the power spectrum of the power spectrum. Results: The resulting ν_max distribution shows a pronounced peak between 20-40 μHz. For about half of the stars we obtain Δ ν with at least two methods. The correlation between ν_max and Δ ν follows the same scaling relation as inferred for solar-like stars. Conclusions: The shape of the ν_max distribution can partly be explained by granulation at low frequencies and by white noise at high frequencies, but the population density of the observed stars turns out to be also an important factor. From the fact that the correlation between Δ ν and ν_max for red giants follows the same scaling relation as obtained for sun-like stars, we conclude that the sound travel time over the pressure scale height of the atmosphere scales with the sound travel time through the whole star irrespective of evolution. The fraction of stars for which we determine Δ ν does not correlate with ν_max in the investigated frequency range, which confirms theoretical predictions. The CoRoT space mission which was developed and is operated by the French space agency CNES, with participation of ESA

Detecting planets in Kepler lightcurves using methods developed for CoRoT.

Science.gov (United States)

Grziwa, S.; Korth, J.; Pätzold, M.

2011-10-01

Launched in March 2009, Kepler is the second space telescope dedicated to the search for extrasolar planets. NASA released 150.000 lightcurves to the public in 2010 and announced that Kepler has found 1.235 candidates. The Rhenish Institute for Environmental Research (RIU-PF) is one of the detection groups from the CoRoT space mission. RIU-PF developed the software package EXOTRANS for the detection of transits in stellar lightcurves. EXOTRANS is designed for the fast automated processing of huge amounts of data and was easily adapted to the analysis of Kepler lightcurves. The use of different techniques and philosophies helps to find more candidates and to rule out others. We present the analysis of the Kepler lightcurves with EXOTRANS. Results of our filter (trend, harmonic) and detection (dcBLS) techniques are compared with the techniques used by Kepler (PDC, TPS). The different approaches to rule out false positives are discussed and additional candidates found by EXOTRANS are presented.

NOAA Climate Data Record (CDR) of GPS RO-Calibrated AMSU Channel 7 (Temperatures of Troposphere / Stratosphere, TTS), Version 1.0 (Version Superseded)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The Climate Data Records (CDR) for Channel 7 contains Radio Occulation (RO) calibrated brightness temperatures from AMSU-A channel 7 measurements at 54.9 GHz from...

Zpráva z výroční konference Britské sociologické asociace: Glasgow 7. - 9. dubna 2010

Czech Academy of Sciences Publication Activity Database

Formánková, Lenka

2010-01-01

Roč. 11, č. 1 (2010), s. 95-100 ISSN 1213-0028 R&D Projects: GA AV ČR IAA700280804 Institutional research plan: CEZ:AV0Z70280505 Keywords : BSA * inequalities * social justice Subject RIV: AO - Sociology, Demography http://www.genderonline.cz

Risk of fall (RoF) intervention by affecting visual egocenter through gait analysis and yoked prisms.

Science.gov (United States)

Padula, William V; Subramanian, Prem; Spurling, April; Jenness, Jonathan

2015-01-01

Following a neurologic event such as traumatic brain injury (TBI), cerebrovascular accident (CVA), and chronic neurological conditions including Parkinson's disease, multiple sclerosis, and cerebral palsy a shift in the visual midline (egocenter) can directly affect posture, balance and spatial orientation. As a consequence, this increases the risk of fall (RoF) and injury that imposes a major financial burden on the public health system. To determine if there is a statistically significant change in balance with the intervention of yoked prisms to reduce the risk of fall in subjects with neurological impairments. Ambulation of thirty-six subjects was evaluated on a pressure sensitive mat before and after intervention with yoked prisms. Changes in gait and balance were analyzed in the anterior-posterior (AP) and medial-lateral (ML) axes during ambulation. T-tests for each measure comparing the difference-of-differences to a zero change at baseline returned statistically significant reductions in both AP (p <  0.0001; 95% CI: 1.368- 2.976) and ML (p = 0.0002; 95% CI: 1.472- 4.173) imbalances using specifically directed yoked prisms to correct the visual midline deviation. These findings demonstrate that yoked prisms have the potential to provide a cost-effective means to restore the visual midline thereby improving balance, reduce RoF and subsequent injury.

Observation and Modelling of the OH, HO2 and RO2 Radicals at a Regional Site of Beijing in Winter 2016.

Science.gov (United States)

Tan, Z.; Lu, K.; Ma, X.; Bohn, B.; Hofzumahaus, A.; Broch, S.; Fuchs, H.; Holland, F.; Liu, Y.; Li, X.; Novelli, A.; Rohrer, F.; Wang, H.; Wu, Y.; Shao, M.; Zeng, L.; Kiendler-Scharr, A.; Wahner, A.; Zhang, Y.

2017-12-01

A comprehensive field campaign was carried out in winter 2016 in the campus of UCAS (University of Chinese Academy of Science), located in a small town 60 km northeast of urban Beijing. Concentrations of OH, HO2 and RO2 radicals as well as the total OH reactivity were measured by a laser induced fluorescence instrument. Maximum hourly averaged OH, HO2 and RO2 radical concentrations were (3±2)×106cm-3, (8±6)×107 cm-3 and (7±5)×107 cm-3, respectively. These radical concentrations were smaller than those observed during summer because of the reduced solar radiation. A chemical modulation device to separate atmospheric OH radicals from any interfering species was applied for few days showing negligible interference for both clean and polluted air masses.HONO and HCHO photolysis were found to be the most important primary sources of ROx radicals. CO and NOx were the important OH reactants which contributed more than half of the total OH reactivity. The relative high OH concentrations in polluted episode enabled a fast oxidation of fresh emitted pollutants and the formation of secondary air products. The observed radical concentrations were compared with the results from a chemical box model. The model is capable of reproducing radical concentrations for moderate NOx conditions but larger discrepancies are observed for both low and high NOx regimes for the peroxy radical concentrations. The underestimation of RO2 radical concentrations for high NOx conditions is discussed in the context of recent campaigns.

The changing phases of extrasolar planet CoRoT-1b.

Science.gov (United States)

Snellen, Ignas A G; de Mooij, Ernst J W; Albrecht, Simon

2009-05-28

Hot Jupiters are a class of extrasolar planet that orbit their parent stars at very short distances. They are expected to be tidally locked, which can lead to a large temperature difference between their daysides and nightsides. Infrared observations of eclipsing systems have yielded dayside temperatures for a number of transiting planets. The day-night contrast of the transiting extrasolar planet HD 189733b was 'mapped' using infrared observations. It is expected that the contrast between the daysides and nightsides of hot Jupiters is much higher at visual wavelengths, shorter than that of the peak emission, and could be further enhanced by reflected stellar light. Here we report the analysis of optical photometric data obtained over 36 planetary orbits of the transiting hot Jupiter CoRoT-1b. The data are consistent with the nightside hemisphere of the planet being entirely black, with the dayside flux dominating the optical phase curve. This means that at optical wavelengths the planet's phase variation is just as we see it for the interior planets in the Solar System. The data allow for only a small fraction of reflected light, corresponding to a geometric albedo of <0.20.

Antibodies to SS-A/Ro-52kD and centromere in autoimmune liver disease: a clue to diagnosis and prognosis of primary biliary cirrhosis.

Science.gov (United States)

Granito, A; Muratori, P; Muratori, L; Pappas, G; Cassani, F; Worthington, J; Ferri, S; Quarneti, C; Cipriano, V; de Molo, C; Lenzi, M; Chapman, R W; Bianchi, F B

2007-09-15

Primary biliary cirrhosis (PBC) may be associated with various rheumatological disorders. To investigate the frequency and significance of 'rheumatological' antinuclear antibodies in the field of autoimmune chronic liver disease, with special regard to PBC. We studied 105 patients with PBC, 162 autoimmune liver disease controls (type 1 and 2 autoimmune hepatitis, primary sclerosing cholangitis), 30 systemic lupus erythematosus and 50 blood donors. Sera were tested for the presence of antibodies to extractable nuclear antigens (anti-ENA) by counterimmunoelectrophoresis, enzyme-linked and immunoblot (IB) assay, and for the presence of anti-centromere antibodies (ACA) by indirect immunofluorescence on HEp-2 cells and IB. The overall prevalence of IB-detected anti-ENA in PBC (30%) was higher than in type 1 autoimmune hepatitis (2.5%, P < 0.0001), type 2 autoimmune hepatitis (0%, P < 0.0001) and primary sclerosing cholangitis (11.5%, P = 0.006) and lower than in systemic lupus erythematosus (53%, P = 0.03). The most frequent anti-ENA reactivity in PBC was anti-SSA/Ro-52kD (28%). ACA were detected by IB in 21% PBC patients and never in the other subjects (P < 0.0001). Anti-SS-A/Ro/52kD positive PBC patients had at the time of diagnosis a more advanced histological stage (P = 0.01) and higher serum levels of bilirubin (P = 0.01) and IgM (P = 0.03) compared with negative ones. In the autoimmune liver disease setting, anti-SS-A/Ro-52kD and ACA have a high specificity for PBC and can thus be of diagnostic relevance in anti-mitochondrial antibodies negative cases. If confirmed in further studies with adequate follow-up, anti-SS-A/Ro-52kD antibodies might identify PBC patients with a more advanced and active disease.

Frequency comparison involving the Romanian primary length standard RO.1 within the framework of the EUROMET Project #498

Science.gov (United States)

Popescu, Gheorghe

2001-06-01

An international frequency comparison was carried out at the Bundesamt fuer Eich- und Vermessungswessen (BEV), Vienna, within the framework of the EUROMET Project #498 from August 29 to September 5, 1999. The frequency differences obtained when the RO.1 laser from the National Institute for Laser, Plasma and Radiation Physics (NILPRP), Romania, was compared with five lasers from Austria (BEV1), Czech Republic (PLD1), France (BIPM3), Poland (GUM1) and Hungary (OMH1) are reported. Frequency differences were computed by using the matrix determinations for the group d, e, f, g. Considering the frequency differences measured for a group of three lasers compared to each other, we call the closing frequency the difference between measured and expected frequency difference (resulting from the previous two measurements). For the RO1 laser, when the BIPM3 laser was the reference laser, the closing frequencies range from +8.1 kHz to - 3.8 kHz. The relative Allan standard deviation was used to express the frequency stability and resulted 3.8 parts in 1012 for 100 s sampling time and 14000 s duration of the measurements. The averaged offset frequency relative to the BIPM4 stationary laser was 5.6 kHz and the standard deviation was 9.9 kHz.

Environmental and economic assessment of hybrid FO-RO/NF system with selected inorganic draw solutes for the treatment of mine impaired water

KAUST Repository

Kim, Jung Eun; Phuntsho, Sherub; Chekli, Laura; Choi, Joon Yong; Shon, Ho Kyong

2018-01-01

draw solution (DS) by conducting environmental and economic life cycle assessment (LCA). Baseline environmental LCA showed that the dominant components to energy use and global warming are the DS recovery processes (i.e. RO or NF processes) and FO

Phase 1 dose-escalation study of the antiplacental growth factor monoclonal antibody RO5323441 combined with bevacizumab in patients with recurrent glioblastoma

DEFF Research Database (Denmark)

Lassen, Ulrik; Chinot, Olivier L; McBain, Catherine

2015-01-01

BACKGROUND: We conducted a phase 1 dose-escalation study of RO5323441, a novel antiplacental growth factor (PlGF) monoclonal antibody, to establish the recommended dose for use with bevacizumab and to investigate the pharmacokinetics, pharmacodynamics, safety/tolerability, and preliminary clinica...

Ro-vibrational averaging of the isotropic hyperfine coupling constant for the methyl radical

Energy Technology Data Exchange (ETDEWEB)

Adam, Ahmad Y.; Jensen, Per, E-mail: jensen@uni-wuppertal.de [Fakultät Mathematik und Naturwissenschaften, Physikalische und Theoretische Chemie, Bergische Universität Wuppertal, D-42097 Wuppertal (Germany); Yachmenev, Andrey; Yurchenko, Sergei N. [Department of Physics and Astronomy, University College London, Gower Street, London WC1E 6BT (United Kingdom)

2015-12-28

We present the first variational calculation of the isotropic hyperfine coupling constant of the carbon-13 atom in the CH{sub 3} radical for temperatures T = 0, 96, and 300 K. It is based on a newly calculated high level ab initio potential energy surface and hyperfine coupling constant surface of CH{sub 3} in the ground electronic state. The ro-vibrational energy levels, expectation values for the coupling constant, and its temperature dependence were calculated variationally by using the methods implemented in the computer program TROVE. Vibrational energies and vibrational and temperature effects for coupling constant are found to be in very good agreement with the available experimental data. We found, in agreement with previous studies, that the vibrational effects constitute about 44% of the constant’s equilibrium value, originating mainly from the large amplitude out-of-plane bending motion and that the temperature effects play a minor role.

Ro-vibrational averaging of the isotropic hyperfine coupling constant for the methyl radical

Science.gov (United States)

Adam, Ahmad Y.; Yachmenev, Andrey; Yurchenko, Sergei N.; Jensen, Per

2015-12-01

We present the first variational calculation of the isotropic hyperfine coupling constant of the carbon-13 atom in the CH3 radical for temperatures T = 0, 96, and 300 K. It is based on a newly calculated high level ab initio potential energy surface and hyperfine coupling constant surface of CH3 in the ground electronic state. The ro-vibrational energy levels, expectation values for the coupling constant, and its temperature dependence were calculated variationally by using the methods implemented in the computer program TROVE. Vibrational energies and vibrational and temperature effects for coupling constant are found to be in very good agreement with the available experimental data. We found, in agreement with previous studies, that the vibrational effects constitute about 44% of the constant's equilibrium value, originating mainly from the large amplitude out-of-plane bending motion and that the temperature effects play a minor role.

Ro-vibrational averaging of the isotropic hyperfine coupling constant for the methyl radical

International Nuclear Information System (INIS)

Adam, Ahmad Y.; Jensen, Per; Yachmenev, Andrey; Yurchenko, Sergei N.

2015-01-01

We present the first variational calculation of the isotropic hyperfine coupling constant of the carbon-13 atom in the CH 3 radical for temperatures T = 0, 96, and 300 K. It is based on a newly calculated high level ab initio potential energy surface and hyperfine coupling constant surface of CH 3 in the ground electronic state. The ro-vibrational energy levels, expectation values for the coupling constant, and its temperature dependence were calculated variationally by using the methods implemented in the computer program TROVE. Vibrational energies and vibrational and temperature effects for coupling constant are found to be in very good agreement with the available experimental data. We found, in agreement with previous studies, that the vibrational effects constitute about 44% of the constant’s equilibrium value, originating mainly from the large amplitude out-of-plane bending motion and that the temperature effects play a minor role

CoRoT/ESTA TASK 1 and TASK 3 comparison of the internal structure and seismic properties of representative stellar models. Comparisons between the ASTEC, CESAM, CLES, GARSTEC and STAROX codes

Science.gov (United States)

Lebreton, Yveline; Montalbán, Josefina; Christensen-Dalsgaard, Jørgen; Roxburgh, Ian W.; Weiss, Achim

2008-08-01

We compare stellar models produced by different stellar evolution codes for the CoRoT/ESTA project, comparing their global quantities, their physical structure, and their oscillation properties. We discuss the differences between models and identify the underlying reasons for these differences. The stellar models are representative of potential CoRoT targets. Overall we find very good agreement between the five different codes, but with some significant deviations. We find noticeable discrepancies (though still at the per cent level) that result from the handling of the equation of state, of the opacities and of the convective boundaries. The results of our work will be helpful in interpreting future asteroseismology results from CoRoT.

A STUDY OF RO-VIBRATIONAL OH EMISSION FROM HERBIG Ae/Be STARS

Energy Technology Data Exchange (ETDEWEB)

Brittain, Sean D.; Reynolds, Nickalas [Department of Physics and Astronomy, 118 Kinard Laboratory, Clemson University, Clemson, SC 29634-0978 (United States); Najita, Joan R. [National Optical Astronomy Observatory, 950 N. Cherry Ave., Tucson, AZ 85719 (United States); Carr, John S. [Naval Research Laboratory, Code 7211, Washington, DC 20375 (United States); Ádámkovics, Máté, E-mail: sbritt@clemson.edu [Department of Astronomy, University of California, Berkeley, CA 94720-3411 (United States)

2016-10-20

We present a study of ro-vibrational OH and CO emission from 21 disks around Herbig Ae/Be stars. We find that the OH and CO luminosities are proportional over a wide range of stellar ultraviolet luminosities. The OH and CO line profiles are also similar, indicating that they arise from roughly the same radial region of the disk. The CO and OH emission are both correlated with the far-ultraviolet luminosity of the stars, while the polycyclic aromatic hydrocarbon (PAH) luminosity is correlated with the longer wavelength ultraviolet luminosity of the stars. Although disk flaring affects the PAH luminosity, it is not a factor in the luminosity of the OH and CO emission. These properties are consistent with models of UV-irradiated disk atmospheres. We also find that the transition disks in our sample, which have large optically thin inner regions, have lower OH and CO luminosities than non-transition disk sources with similar ultraviolet luminosities. This result, while tentative given the small sample size, is consistent with the interpretation that transition disks lack a gaseous disk close to the star.

Propiedades estructurales, electrónicas y magnéticas de la perovskita BiRO3

Directory of Open Access Journals (Sweden)

C. E. Deluque Toro

2011-07-01

Full Text Available We present a detailed study about the structural properties, electronic and magnetic states BiRO3 perovskites, with R= Fe, Co, Ni, cubic structure and group of symmetry Pm-3m. By obtaining results was used the Spin polarized Full-Potential Linear Augmented Plane Wave method (SP-FP-LAPW into the framework the Theory Functional Density (DFT.The structural study consist to calculate the cohesion energy as a function of volume and by means of the Murnaghan state equation, bulk modulus, equilibrium volume and lattice constant was determinated. Studying the electronic characteristic the energy curves in function of wave number (k and the density of states (DOS with polarized spin was calculated.

Environmental and economic assessment of hybrid FO-RO/NF system with selected inorganic draw solutes for the treatment of mine impaired water

KAUST Repository

Kim, Jung Eun

2018-01-01

A hybrid forward osmosis (FO) and reverse osmosis (RO)/nanofiltration (NF) system in a closed-loop operation with selected draw solutes was evaluated to treat coal mine impaired water. This study provides an insight of selecting the most suitable draw solution (DS) by conducting environmental and economic life cycle assessment (LCA). Baseline environmental LCA showed that the dominant components to energy use and global warming are the DS recovery processes (i.e. RO or NF processes) and FO membrane materials, respectively. When considering the DS replenishment in FO, the contribution of chemical use to the overall global warming impact was significant for all hybrid systems. Furthermore, from an environmental perspective, the FO-NF hybrid system with Na2SO4 shows the lowest energy consumption and global warming with additional considerations of final product water quality and FO brine disposal. From an economic perspective, the FO-NF with Na2SO4 showed the lowest total operating cost due to its lower DS loss and relatively low solute cost. In a closed-loop system, FO-NF with NaCl and Na2SO4 had the lowest total water cost at optimum NF recovery rates of 90 and 95%, respectively. FO-NF with Na2SO4 had the lowest environmental and economic impacts. Overall, draw solute performances and cost in FO and recovery rate in RO/NF play a crucial role in determining the total water cost and environmental impact of FO hybrid systems in a closed-loop operation.

Close-up of primary and secondary asteroseismic CoRoT targets and the ground-based follow-up observations

Energy Technology Data Exchange (ETDEWEB)

Uytterhoeven, K; Poretti, E; Rainer, M; Mantegazza, L [INAF-Brera Astronomical Observatory, Via E. Bianchi 46, 23807 Merate (Italy); Zima, W; Aerts, C; Morel, T; Lefever, K [Institute of Astronomy, KULeuven, Celestijnenlaan 200D, 3001 Leuven (Belgium); Miglio, A [Institut d' Astrophysique et de Geophysique de l' Universite de Liege, Allee du 6 Aout 17, 4000 Liege (Belgium); Amado, P J; MartIn-Ruiz, S [Instituto de AstrofIsica de AndalucIa (CSIC), Apartado 3004, 18080 Granada (Spain); Mathias, P; Valtier, J C [Observatoire de la Cote d' Azur, GEMINI, CNRS, Universite Nice Sophia-Antipolis, BP 4229, 06304 Nice Cedex 4 (France); Paparo, M; Benkoe, J M [Konkoly Observatory, PO Box 67, 1525 Budapest (Hungary)], E-mail: katrien.uytterhoeven@brera.inaf.it

2008-10-15

To optimise the science results of the asteroseismic part of the CoRoT satellite mission a complementary simultaneous ground-based observational campaign is organised for selected CoRoT targets. The observations include both high-resolution spectroscopic and multicolour photometric data. We present the preliminary results of the analysis of the ground-based observations of three targets. A line-profile analysis of 216 high-resolution FEROS spectra of the {delta} Sct star HD 50844 reveals more than ten pulsation frequencies in the frequency range 5-18 d{sup -1}, including possibly one radial fundamental mode (6.92 d{sup -1}). Based on more than 600 multi-colour photometric datapoints of the {beta} Cep star HD 180642, spanning about three years and obtained with different telescopes and different instruments, we confirm the presence of a dominant radial mode {nu}{sub 1} = 5.48695 d{sup -1}, and detect also its first two harmonics. We find evidence for a second mode {nu}{sub 2} = 0.3017 d{sup -1}, possibly a g-mode, and indications for two more frequencies in the 7-8 d{sup -1} domain. From Stromgren photometry we find evidence for the hybrid 5 Sct/{gamma} Dor character of the F0 star HD 44195, as frequencies near 3 d{sup -1} and 21 d{sup -1} are detected simultaneously in the different filters.

Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells

OpenAIRE

van Loosdregt, Jorg; Spreafico, Roberto; Rossetti, Maura; Prakken, Berent J; Lotz, Martin; Albani, Salvatore

2013-01-01

Although hydroxychloroquine is used for treatment of numerous autoimmune disorders the mechanism is unclear. We here demonstrate that hydroxychloroquine preferentially induces apoptosis of CD45RO+ memory and effector T cells by inhibiting the survival pathway of autophagy.

Treatment of reverse osmosis (RO) concentrate by the combined Fe/Cu/air and Fenton process (1stFe/Cu/air-Fenton-2ndFe/Cu/air).

Science.gov (United States)

Ren, Yi; Yuan, Yue; Lai, Bo; Zhou, Yuexi; Wang, Juling

2016-01-25

To decompose or transform the toxic and refractory reverse osmosis (RO) concentrate and improve the biodegradability, 1stFe/Cu/air-Fenton-2ndFe/Cu/air were developed to treat RO concentrate obtained from an amino acid production plant in northern China. First, their operating conditions were optimized thoroughly. Furthermore, 5 control experiments were setup to confirm the superiority of 1stFe/Cu/air-Fenton-2ndFe/Cu/air and synergistic reaction between Fe/Cu/air and Fenton. The results suggest that the developed method could obtain high COD removal (65.1%) and BOD5/COD ratio (0.26) due to the synergistic reaction between Fe/Cu/air and Fenton. Under the optimal conditions, the influent and effluent of 1stFe/Cu/air-Fenton-2ndFe/Cu/air and 5 control experiments were analyzed by using UV, FTIR, EEM and LC, which confirm the superiority of 1stFe/Cu/air-Fenton-2ndFe/Cu/air. Therefore, the developed method in this study is a promising process for treatment of RO concentrate. Copyright © 2015 Elsevier B.V. All rights reserved.

Radiosensitizing and toxic effects of the 2-nitroimidazole Ro-07-0582 in different phases of the cell cycle of extremely hypoxic human cells in vitro

International Nuclear Information System (INIS)

Petterson, E.O.

1978-01-01

The radiosensitizing effect of 5 and 30 mM of Ro-07-0582 (misonidazole) has been studied at different stages of the cell cycle of mitotically selected NHIK 3025 cells under aerobic and extremely hypoxic conditions. For cells irradiated under aerobic conditions no sensitizing effect was seen at any stage of the cell cycle. For cells irradiated under extremely hypoxic conditions there was a lower sensitizing effect in mid-G1 than in mid-S for low radiation doses (in the initial region of the dose-response curves). For high radiation doses, however, no significant difference in sensitizing effect on cells in mid-G1 and in mid-S was seen. For cells in mid-G1 the sensitizing effect increased with increasing radiation dose. The toxic effect of 30 mM Ro-07-0582 as measured by loss of reproductive capacity was studied at room temperature for contact times up to 6 hours under aerobic conditions and 3 hours under extremely hypoxic conditions. While no effect was seen under aerobic conditions there was a toxic effect for contact intervals above 1 hour under extremely hypoxic conditions. Cells in S were more sensitive to the toxic effect of Ro-07-0582 than cells in G1. Implications for clinical use are discussed

Ultraviolet radiation (UVR) induces cell-surface Ro/SSA antigen expression by human keratinocytes in vitro: a possible mechanism for the UVR induction of cutaneous lupus lesions

International Nuclear Information System (INIS)

Jones, S.K.

1992-01-01

Antinuclear antibodies are useful markers of connective tissue disease. In this study, UVB but not UVA induced the expression of Ro/SSA antigen on keratinocyte surfaces in vitro. This expression was also found with the extractable nuclear antigens RnP and Sm, but not with single or double-stranded DNA. The expression was prevented by blocking protein synthesis, suggesting that it was an active process. The results suggest that UVB exposure may result in the expression of Ro/SSA antigen on the surfaces of basal keratinocytes in vivo. This antigen could then bind circulating antibody leading to the cutaneous lesions in neonatal and subacute cutaneous lupus erythematosus. (Author)

Effect of the nitroimidazole Ro 03-8799 on the activity of chemotherapeutic agents against a murine tumour in vivo.

OpenAIRE

Sheldon, P. W.; Gibson, P.

1984-01-01

The effect of the 2-nitroimidazole Ro 03-8799 (8799) on the activity of 11 chemotherapeutic agents against the anaplastic MT tumour in mice has been determined by soft agar cloning. The 8799, whilst producing little cytotoxicity by itself, potentiated the cytotoxic actions of the alkylating agents melphalan and cyclophosphamide, and the nitrosoureas BCNU, CCNU and MeCCNU. This potentiation was influenced by the time interval between the administration of 8799 and the chemotherapeutic agents, ...

Chromosomes, genes, and colonization events in European mammals

Czech Academy of Sciences Publication Activity Database

Zima, Jan

2007-01-01

Roč. 1, Supp. (2007), s. 49 ISSN 1825-5272. [ European Congress of Mammalogy /5./. 21.09.2007-26.09.2007, Siena] Institutional research plan: CEZ:AV0Z60930519 Keywords : European mammals Subject RIV: EB - Genetics ; Molecular Biology

CD147 (Basigin/Emmprin) identifies FoxP3+CD45RO+CTLA4+-activated human regulatory T cells.

Science.gov (United States)

Solstad, Therese; Bains, Simer Jit; Landskron, Johannes; Aandahl, Einar Martin; Thiede, Bernd; Taskén, Kjetil; Torgersen, Knut Martin

2011-11-10

Human CD4(+)FoxP3(+) T cells are functionally and phenotypically heterogeneous providing plasticity to immune activation and regulation. To better understand the functional dynamics within this subset, we first used a combined strategy of subcellular fractionation and proteomics to describe differences at the protein level between highly purified human CD4(+)CD25(+) and CD4(+)CD25(-) T-cell populations. This identified a set of membrane proteins highly expressed on the cell surface of human regulatory T cells (Tregs), including CD71, CD95, CD147, and CD148. CD147 (Basigin or Emmprin) divided CD4(+)CD25(+) cells into distinct subsets. Furthermore, CD147, CD25, FoxP3, and in particular CTLA-4 expression correlated. Phenotypical and functional analyses suggested that CD147 marks the switch between resting (CD45RA(+)) and activated (CD45RO(+)) subsets within the FoxP3(+) T-cell population. Sorting of regulatory T cells into CD147(-) and CD147(+) populations demonstrated that CD147 identifies an activated and highly suppressive CD45RO(+) Treg subset. When analyzing CD4(+) T cells for their cytokine producing potential, CD147 levels grouped the FoxP3(+) subset into 3 categories with different ability to produce IL-2, TNF-α, IFN-γ, and IL-17. Together, this suggests that CD147 is a direct marker for activated Tregs within the CD4(+)FoxP3(+) subset and may provide means to manipulate cells important for immune homeostasis.

SpRoUTS (Space Robot Universal Truss System): Reversible Robotic Assembly of Deployable Truss Structures of Reconfigurable Length

Science.gov (United States)

Jenett, Benjamin; Cellucci, Daniel; Cheung, Kenneth

2015-01-01

Automatic deployment of structures has been a focus of much academic and industrial work on infrastructure applications and robotics in general. This paper presents a robotic truss assembler designed for space applications - the Space Robot Universal Truss System (SpRoUTS) - that reversibly assembles a truss from a feedstock of hinged andflat-packed components, by folding the sides of each component up and locking onto the assembled structure. We describe the design and implementation of the robot and show that the assembled truss compares favorably with prior truss deployment systems.

Sherpa/RoMEO, institucionální repozitář AV ČR a otevřený přístup (open access)

Czech Academy of Sciences Publication Activity Database

Burešová, Iva

-, č. 1 (2012), s. 1-12 E-ISSN 1805-2800 Keywords : Sherpa/RoMEO * open access * institucional repositories * Library of ASCR * copyright http://www.lib.cas.cz/casopis-informace/sherparomeo-institucionalni-repozitar-av-cr-a-otevreny-pristup- open - access /

Mezinárodní konference k 150. výročí narození srbského geologa, geografa a etnografa Jovana Cvijiće

Czech Academy of Sciences Publication Activity Database

Pospíšilová, Jana

2016-01-01

Roč. 103, č. 1 (2016), s. 137-138 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : Jovan Cvijić * Ethnology * Geology * Conference * 150th Anniversary of Birth Subject RIV: AC - Archeology, Anthropology, Ethnology

IMPROVED VARIABLE STAR SEARCH IN LARGE PHOTOMETRIC DATA SETS: NEW VARIABLES IN CoRoT FIELD LRa02 DETECTED BY BEST II

International Nuclear Information System (INIS)

Fruth, T.; Cabrera, J.; Csizmadia, Sz.; Eigmüller, P.; Erikson, A.; Kirste, S.; Pasternacki, T.; Rauer, H.; Titz-Weider, R.; Kabath, P.; Chini, R.; Lemke, R.; Murphy, M.

2012-01-01

The CoRoT field LRa02 has been observed with the Berlin Exoplanet Search Telescope II (BEST II) during the southern summer 2007/2008. A first analysis of stellar variability led to the publication of 345 newly discovered variable stars. Now, a deeper analysis of this data set was used to optimize the variability search procedure. Several methods and parameters have been tested in order to improve the selection process compared to the widely used J index for variability ranking. This paper describes an empirical approach to treat systematic trends in photometric data based upon the analysis of variance statistics that can significantly decrease the rate of false detections. Finally, the process of reanalysis and method improvement has virtually doubled the number of variable stars compared to the first analysis by Kabath et al. A supplementary catalog of 272 previously unknown periodic variables plus 52 stars with suspected variability is presented. Improved ephemerides are given for 19 known variables in the field. In addition, the BEST II results are compared with CoRoT data and its automatic variability classification.

Re-exploration of the mGlu₁ PAM Ro 07-11401 scaffold: Discovery of analogs with improved CNS penetration despite steep SAR.

Science.gov (United States)

Garcia-Barrantes, Pedro M; Cho, Hyekyung P; Starr, Tahj M; Blobaum, Anna L; Niswender, Colleen M; Conn, P Jeffrey; Lindsley, Craig W

2016-05-01

This letter describes the re-exploration of the mGlu1 PAM Ro 07-11401 scaffold through a multi-dimensional, iterative parallel synthesis approach. Unlike recent series of mGlu1 PAMs with robust SAR, the SAR around the Ro 07-11401 structure was incredibly steep (only ∼6 of 200 analogs displayed mGlu1 PAM activity), and reminiscent of the CPPHA mGlu5 PAM scaffold. Despite the steep SAR, two new thiazole derivatives were discovered with improved in vitro DMPK profiles and ∼3- to 4-fold improvement in CNS exposure (Kps 1.01-1.19); albeit, with a ∼3-fold diminution in mGlu1 PAM potency, yet comparable efficacy (∼5-fold leftward shift of the glutamate concentration-response curve at 10μM). Thus, this effort has provided additional CNS penetrant mGlu1 PAM tools in a different chemotype than the VU0486321 scaffold. These compounds will permit a better understanding of the pharmacology and therapeutic potential of selective mGlu1 activation, while highlighting the steep SAR challenges that can often be encountered in GPCR allosteric modulator discovery. Copyright © 2016 Elsevier Ltd. All rights reserved.

The Politics of European Human Rights Culture

Czech Academy of Sciences Publication Activity Database

Agha, Petr

2017-01-01

Roč. 7, č. 3 (2017), s. 200-215 ISSN 1805-8396 R&D Projects: GA ČR GA13-30299S Institutional support: RVO:68378122 Keywords : Court of Justice of the European Union * European Court of Human Rights * religious symbols Subject RIV: AG - Legal Sciences OBOR OECD: Law

Characterization of resistance to Globodera rostochiensis pathotype Ro1 in cultivated and wild potato species accessions from the Vavilov Institute of Plant Industry

Science.gov (United States)

Potato cyst nematodes (PCN) in Russia are represented by only Globodera rostochiensis pathotype Ro1. It is a quarantine pathogen with losses in yield in susceptible cultivars which can reach 50-90%. The aims of our study were to verify the species and pathotype composition of natural PCN populations...

NOVÉ NA STARÉ – Brno, nároží Bratislavská - Stará

OpenAIRE

Červinková, Kateřina

2014-01-01

Řešené území se nachází v městské části Brno-střed, na nárožní poloze ulic Bratislavská a Stará. Je tvořeno několika parcelami, které jsou v současné době nezastaveny, nebo se na nich nachází stavby dočasného charakteru. Část vymezeného území dnes slouží jako parkoviště Policie České republiky. Od historického centra ji dělí dopravní - malý městský okruh vedoucí ulicí Koliště. V blízkosti řešeného území jsou městské domy většinou s obchodním parterem, postavené v rozmezí konce 19. - 1.pol. 20...

VIRULENT GROUP Ro1,4 POTATO GOLDEN CYST NEMATODES (Globodera rostochiensis WOLLENWEBER IN CROATIA

Directory of Open Access Journals (Sweden)

Marija Ivezić

2005-06-01

Full Text Available The potato golden cyst nematode (Globodera rostochiensis WOLLENWEBER is very important potato pest. According to EPPO it is on the quarantines A2 list. This species was detected on the territory of Belice in 2001. In 2002 soil samples were taken on two treatments, one with potato in monoculture and the other on the wheat where potato was previous crop. Cysts extraction was done in the laboratory of nematology at the Faculty of Agriculture in Osijek and Swedish University of Agriculture Sciences, Department of Crop Science. Virulent group Ro1,4 was detected. More cysts were discovered in the monoculture potato soil (458/100 ccm of soil than in the soil under the wheat (368/100 ccm of soil. In 2004 vitality of the cysts were analysed. Cysts from potato monoculture had higher vitality (203 larvae/ cyst than cyst from the soil under wheat (38 larvae/cyst with potato as previous crop.

Mott state and quantum critical points in rare-earth oxypnictides RO1-xFxFeAS (R= La, Sm, Nd, Pr, Ce)

NARCIS (Netherlands)

Giovannetti, G.; Kumar, S.; van den Brink, J.

2008-01-01

We investigate the magnetic phase diagram of the newly discovered iron-based high temperature oxypnictide superconductors of the type RO1-xFxFeAs, with rare earths R=La, Sm, Nd, Pr and Ce by means of ab initio SGGA and SGGA+U density functional computations. We find undoped LaOFeAs to be a Mott

Konference European Studies: between Globalisation and Regionalism

Czech Academy of Sciences Publication Activity Database

Laštovková, Jitka

2006-01-01

Roč. 42, č. 5 (2006), s. 1009-1010 ISSN 0038-0288. [European Studies: between Globalisation and Regionalism. Šiauliai, 12.05.2006-03.05.2006] Institutional research plan: CEZ:AV0Z70280505 Keywords : conference * European identitiy * globalization Subject RIV: AO - Sociology, Demography Impact factor: 0.128, year: 2006

Port of Rotterdam

NARCIS (Netherlands)

Veenstra, A.W.

2014-01-01

The port of Rotterdam is one of the largest ports in the World and has great significance for the Dutch and European economy. Newly appointed TU/e professor Albert Veenstra explains if and how the Port of Rotterdam is affected by the economic crisis. With other European ports closing in, what can

Scopeloides glarisianus (Gonostomatidae, Stomiiformes) na středně oligocenní lokalitě Rožnov pod Radhoštěm – Rysova hora

Czech Academy of Sciences Publication Activity Database

Přikryl, Tomáš

2008-01-01

Roč. 2007, - (2008), s. 130-131 ISSN 0514-8057 Institutional research plan: CEZ:AV0Z30130516 Keywords : fish * biostratigraphy * Western Carpathians * Paleogene Subject RIV: DB - Geology ; Mineralogy http://www.geology.cz/zpravy/obsah/2007/2007-36.pdf

Cena Klubu Za starou Prahu za novou stavbu v historickém prostředí: třináct ročníků

Czech Academy of Sciences Publication Activity Database

Švácha, Rostislav

2017-01-01

Roč. 77, č. 4 (2017), s. 467-472 ISSN 1210-5538 Institutional support: RVO:68378033 Keywords : architecture * contemporary architecture * historic building Subject RIV: AL - Art, Architecture, Cultural Heritage

Suitability of second pass RO as a substitute for high quality MSF product water in Nuclear Desalination Demonstration Plant

International Nuclear Information System (INIS)

Murugan, V.; Venkatesh, P.; Balasubramanian, C.; Nagaraj, R.; Yadav, Manoj Kumar; Prabhakar, S.; Tewari, P.K.

2012-01-01

Nuclear Desalination Demonstration Plant at Kalpakkam consists of both Multi Stage Flash Distillation (MSF) and Seawater Reverse Osmosis (SWRO) process to produce desalinated water. It supplies part of highly pure water from MSF to Madras Atomic Power Station for its boiler feed requirements and remaining water is blend with SWRO product water and sent to other common facilities located inside Kalpakkam campus. A critical techno-economic analysis is carried out to find out the suitability of second pass RO to sustain the availability of highly pure water in case of MSF plant shutdown. (author)

State of the art and challenges in development of electrical contact materials in the light of the RoHS directive

Directory of Open Access Journals (Sweden)

Ćosović V.

2012-01-01

Full Text Available The article surveys current state of the art and challenges in the development of the electrical contact materials in the light of the EU Directive on Restriction of Hazardous Substances (RoHS. The focus was placed on widely used silver-cadmium alloys. According to this directive, as of July 1, 2006, use of six hazardous materials, including cadmium, are restricted for applicable electrical and electronic products intended for the EU market. In contrast, traditionally preferred material for production of electrical contacts is Ag-CdO, due to its outstanding functional properties. These conflicting interests result in present state where RoHS directive has not yet been implemented in its original form and has undergone numerous amendments and exceptions regarding the use of cadmium. Main reason for this seems to be the unrealistic time frame imposed by legislation. Although, significant effort has been put into research and development of alternative materials, there are still cases where adequate replacement materials had not been found. Therefore, importance of synchronicity between legislation and technological progress i.e. communication between legislative administration and industry and academia is brought to light as well as some common issues that may arise with an introduction of new replacement materials or product modification. [Projekat Ministarstva nauke Republike SRbije, br. OI 172037 and TR 34023

Effectiveness of Subsidies in Technology Adoption: A Case Study Involving Reverse Osmosis (RO Membrane Technology

Directory of Open Access Journals (Sweden)

Nur Laili

2016-12-01

Full Text Available Adoption of new technologies is a process that involves technological learning and penetration of new products into the market. Within the process of new technologies adoption, government usually intervened by providing incentives, in order to support the technology adoption to be succeed. This paper examines the effectiveness of incentives for the sustainability of reverse osmosis (RO membrane technology adoption. The study conducted through single case study on SWRO installation in Mandangin Island, East Java, Indonesia. Results of case study indentify the existence of government incentive in the form of direct subsidies to decrease the price of clean water. Although successful in reducing the price of water, but effectiveness of the subsidy on the sustainability of SWRO is still low, which is operates only 30% in a year. Further analysis shows that these subsidies actually be counter-productive to the sustainability of SWRO installation.

Phase I expansion and pharmacodynamic study of the oral MEK inhibitor RO4987655 (CH4987655) in selected patients with advanced cancer with RAS-RAF mutations

NARCIS (Netherlands)

Zimmer, Lisa; Barlesi, Fabrice; Martinez-Garcia, Maria; Dieras, Veronique; Schellens, Jan H M; Spano, Jean-Philippe; Middleton, Mark R; Calvo, Emiliano; Paz-Ares, Luiz; Larkin, James; Pacey, Simon; Venturi, Miro; Kraeber-Bodéré, Françoise; Tessier, Jean J L; Eberhardt, Wilfried Ernst Erich; Paques, Michel; Guarin, Ernesto; Meresse, Valerie; Soria, Jean-Charles

2014-01-01

PURPOSE: This phase I expansion study assessed safety, pharmacodynamic effects, and antitumor activity of RO4987655, a pure MEK inhibitor, in selected patients with advanced solid tumor. EXPERIMENTAL DESIGN: We undertook a multicenter phase I two-part study (dose escalation and cohort expansion).

Removal of organic micro-pollutants (phenol, aniline and nitrobenzene) via forward osmosis (FO) process: Evaluation of FO as an alternative method to reverse osmosis (RO)

KAUST Repository

Cui, Yue; Liu, Xiang-Yang; Chung, Neal Tai-Shung; Weber, Martin; Staudt, Claudia; Maletzko, Christian

2016-01-01

under the RO mode. In addition, the rejection can be maintained even when treating a more concentrated feed solution (2000 ppm). The removal performance can be further enhanced by using a more concentrated draw solution (2 M). The water flux is almost

The effect of RO3201195 and a pyrazolyl ketone P38 MAPK inhibitor library on the proliferation of Werner syndrome cells.

Science.gov (United States)

Bagley, Mark C; Dwyer, Jessica E; Baashen, Mohammed; Dix, Matthew C; Murziani, Paola G S; Rokicki, Michal J; Kipling, David; Davis, Terence

2016-01-21

Microwave-assisted synthesis of the pyrazolyl ketone p38 MAPK inhibitor RO3201195 in 7 steps and 15% overall yield, and the comparison of its effect upon the proliferation of Werner Syndrome cells with a library of pyrazolyl ketones, strengthens the evidence that p38 MAPK inhibition plays a critical role in modulating premature cellular senescence in this progeroid syndrome and the reversal of accelerated ageing observed in vitro on treatment with SB203580.

Sto ročníků Českého lidu v osobách a poselstvích vedoucích redaktorů

Czech Academy of Sciences Publication Activity Database

Woitsch, Jiří

2013-01-01

Roč. 100, č. 1 (2013), s. 63-98 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : the journal Český lid * history of regional history * history of science * academic writing Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.094, year: 2012

Vladimír Vand - konstruktér mechanických počítačů : k 100. výročí narození

Czech Academy of Sciences Publication Activity Database

Křížek, Michal; Šolcová, A.

2011-01-01

Roč. 56, č. 1 (2011), s. 19-34 ISSN 0032-2423 R&D Projects: GA AV ČR(CZ) IAA100190803 Institutional research plan: CEZ:AV0Z10190503 Keywords : Vladimir Vand * mechanical computers Subject RIV: BA - General Mathematics http://dml.cz/dmlcz/141983

Monsignor Celso Costantini a Čína (k 90. výročí prvního čínského koncilu v Šanghaji, 1924)

Czech Academy of Sciences Publication Activity Database

Liščák, Vladimír

2013-01-01

Roč. 4, č. 2 (2013), s. 45-53 ISSN 1804-6657 Institutional support: RVO:68378009 Keywords : Catholic Church in China * localization and inculturation * ordination of the first Chinese bishops Subject RIV: AB - History

Artificial Recharge – Measurement of Soil Infiltration in Rožnov Pod Radhoštěm

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Chromíková Jitka

2017-12-01

Full Text Available The purpose of this study is to evaluate the potential for infiltration in a study area – Rožnov pod Radhoštěm, the Czech Republic. The results are important for the future design of an artificial recharge structure as a method to store water underground in times of water surplus. A total of six measurements of infiltration were made using a double ring infiltrometer on selected prospective sites for the future application of artificial recharge. The results of infiltration tests were analysed based on the Philip’s model. The steady soil infiltration rates ranged from 28 cm∙h−1 to 70.38 cm∙h−1and the cumulative soil infiltration ranged from 58 cm to 68 cm.

Finanční analýza společnosti Unilever ČR, spol. s r.o.

OpenAIRE

Richter, Martin

2006-01-01

Finanční analýza společnosti Unilever ČR, spol. s r.o. za období 2002 až 2005. Unilever ČR je česká pobočka nadnárodního koncernu produkujícího potravinářské a spotřební zboží. Metodologická část práce popisuje úlohu finanční analýzy a jednotlivé její metody a postupy. Praktická část analyzuje společnost Unilever ČR se zaměřením na celkovou hospodářskou situaci a výsledky podnikových programů a strategií.

Estudo de dose adequada da droga RO42-1611 (Arteflene) no tratamento da malária por Plasmodium falciparum

OpenAIRE

SILVA, Rita do Socorro Uchôa

1997-01-01

A resistência crescente do P. falciparum aos antimaláricos habitualmente empregados, torna urgente a avaliação de novas drogas. O Ro 42-1611 é um antimalárico derivado da planta chinesa Arlabotrys uncinatus. Usado apenas na África em três trabalhos no tratamento da malária por P. falciparum, tem sua ação desconhecida em sul-americanos com esta doença. Apesar do efeito antimalárico ter sido comprovado, ainda não se encontrou a dose adequada para o tratamento supressivo do P. falciparum. Avalia...

A High-Throughput Oxidative Stress Biosensor Based on Escherichia coli roGFP2 Cells Immobilized in a k-Carrageenan Matrix

Directory of Open Access Journals (Sweden)

Lia Ooi

2015-01-01

Full Text Available Biosensors fabricated with whole-cell bacteria appear to be suitable for detecting bioavailability and toxicity effects of the chemical(s of concern, but they are usually reported to have drawbacks like long response times (ranging from hours to days, narrow dynamic range and instability during long term storage. Our aim is to fabricate a sensitive whole-cell oxidative stress biosensor which has improved properties that address the mentioned weaknesses. In this paper, we report a novel high-throughput whole-cell biosensor fabricated by immobilizing roGFP2 expressing Escherichia coli cells in a k-carrageenan matrix, for the detection of oxidative stress challenged by metalloid compounds. The E. coli roGFP2 oxidative stress biosensor shows high sensitivity towards arsenite and selenite, with wide linear range and low detection limit (arsenite: 1.0 × 10−3–1.0 × 101 mg·L−1, LOD: 2.0 × 10−4 mg·L−1; selenite: 1.0 × 10−5–1.0 × 102 mg·L−1, LOD: 5.8 × 10−6 mg·L−1, short response times (0–9 min, high stability and reproducibility. This research is expected to provide a new direction in performing high-throughput environmental toxicity screening with living bacterial cells which is capable of measuring the bioavailability and toxicity of environmental stressors in a friction of a second.

Poznatky o psychické odolnosti malých skupin izolovaných v náročných podmínkách

Czech Academy of Sciences Publication Activity Database

Šolcová, Iva

2008-01-01

Roč. 52, č. 3 (2008), s. 253-264 ISSN 0009-062X R&D Projects: GA AV ČR(CZ) IAA700250701 Institutional research plan: CEZ:AV0Z70250504 Keywords : space flights * space flight simulation * cultural differences Subject RIV: AN - Psychology Impact factor: 0.101, year: 2008

Effect of line-of-sight inclinations on the observation of solar activity cycle: Lessons for CoRoT and Kepler

International Nuclear Information System (INIS)

Vazquez Ramio, H; Regulo, C; Mathur, S; GarcIa, R A

2011-01-01

CoRoT and Kepler missions are collecting data of solar-like oscillating stars of unprecedented quality. Moreover, thanks to the length of the time series, we are able to study their seismic variability. In this work we use numerical simulations based on the last 3 solar cycles to analyze the light curves as a function of the line-of-sight inclination angle. These preliminary results showed that the direct observation of the light curve can induce some bias in the position of the maximum of the cycle.

Monoamine oxidase B single-photon emission tomography with [123I]Ro 43-0463: imaging in volunteers and patients with temporal lobe epilepsy

International Nuclear Information System (INIS)

Buck, A.; Frey, L.D.; Blaeuenstein, P.; Schubiger, P.; Kraemer, G.; Siegel, A.; Weber, B.; Wieser, H.G.

1998-01-01

Imaging of monoamine oxidase of subtype B (MAO B) is of interest in various neurological diseases. In the past non-invasive assessment of MAO B has only been possible with positron emission tomography (PET) ligands. Given the limited availability of PET, a single-photon emission tomography (SPET) ligand would be desirable. In this study SPET imaging with the new MAO B inhibitor [ 123 I]Ro 43-0463 was performed in five volunteers and nine patients with temporal lobe epilepsy (TLE). In two volunteers a second study was performed 12 h following blockade with deprenyl. In the TLE patients the tracer was administered as bolus (n = 4) or as prolonged infusion (n = 5). The regional uptake pattern correlated well with the known distribution of MAO B. In the two blocking studies ligand uptake was substantially reduced compared with baseline. In the TLE patients increased uptake was found in the ipsilateral mesial temporal lobe and, surprisingly, in the ipsilateral putamen. This study indicates the potential of the new SPET ligand [ 123 I]Ro 43-0463 to map MAO B concentration in the human brain. The new finding of increased MAO B in the putamen of TLE patients needs further studies to elucidate its exact pathophysiology. (orig.)

Co-expression of nuclear and cytoplasmic HMGB1 is inversely associated with infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer

International Nuclear Information System (INIS)

Peng, Rui-Qing; Zeng, Yi-Xin; Zhang, Xiao-Shi; Wu, Xiao-Jun; Ding, Ya; Li, Chun-Yan; Yu, Xing-Juan; Zhang, Xing; Pan, Zhi-Zhong; Wan, De-Sen; Zheng, Li-Ming

2010-01-01

The intratumoral infiltration of T cells, especially memory T cells, is associated with a favorable prognosis in early colorectal cancers. However, the mechanism underlying this process remains elusive. This study examined whether high-mobility group box 1 (HMGB1), a damage-associated molecular pattern (DAMP) molecule, is involved in the infiltration of T cells and disease progression in locally advanced colon cancer. Seventy-two cases of pathologically-confirmed specimens were obtained from patients with stage IIIB (T3N1M0) colon cancer who underwent radical resection between January 1999 and May 2002 at the Cancer Center of Sun Yat-Sen University. The density of tumor-infiltrating lymphocytes (TILs) within the tumor tissue and the expression of HMGB1 in the cancer cells were examined via immunohistochemical analysis. The phenotype of CD45RO+ cells was confirmed using a flow cytometric assay. The association between HMGB1 expression, the density of TILs, and the 5-year survival rate were analyzed. The density of CD45RO+ T cells within the tumor was independently prognostic, although a higher density of CD3+ T cells was also associated with a favorable prognosis. More importantly, the expression of HMGB1 was observed in both the nucleus and the cytoplasm (co-expression pattern) in a subset of colon cancer tissues, whereas nuclear-only expression of HMGB1 (nuclear expression pattern) existed in most of the cancer tissues and normal mucosa. The co-expression pattern of HMGB1 in colon cancer cells was inversely associated with the infiltration of both CD3+ and CD45RO+ T cells and 5-year survival rates. This study revealed that the co-expression of HMGB1 is inversely associated with the infiltration of CD45RO+ T cells and prognosis in patients with stage IIIB colon cancer, indicating that the distribution patterns of HMGB1 might contribute to the progression of colon cancer via modulation of the local immune response

European Birth Cohorts for Environmental Health Research

Czech Academy of Sciences Publication Activity Database

Vrijheid, M.; Casas, M.; Bergström, A.; Carmichael, A.; Cordier, S.; Eggesbø, M.; Eller, E.; Fantini, M. P.; Fernández, M. F.; Fernández-Somoano, A.; Gehring, U.; Grazuleviciene, R.; Hohmann, C.; Karvonen, A. M.; Keil, T.; Kogevinas, M.; Koppen, G.; Krämer, U.; Kuehni, C. E.; Magnus, P.; Majewska, R.; Andersen, A. M. N.; Patelarou, E.; Petersen, M. S.; Pierik, F. H.; Polanska, K.; Porta, D.; Richiardi, L.; Santos, A. C.; Slama, R.; Šrám, Radim; Thijs, C.; Tischer, C.; Toft, G.; Trnovec, T.; Vandentorren, S.; Vrijkotte, T. G. M.; Wilhelm, M.; Wright, J.; Nieuwenhuijsen, M.

2012-01-01

Roč. 120, č. 1 (2012), s. 29-37 ISSN 0091-6765 Institutional research plan: CEZ:AV0Z50390703 Keywords : environment pollution * child health * European birth cohorts Subject RIV: DN - Health Impact of the Environment Quality Impact factor: 7.260, year: 2012

New RO TFC Membranes by Interfacial Polymerization in n-Dodecane with Various co-Solvents.

Science.gov (United States)

Al-Hobaib, Abdullah Sulaiman; Al-Suhybani, Mohammed Sulaiman; Al-Sheetan, Khalid Mohammed; Mousa, Hasan; Shaik, Mohammed Rafi

2016-04-29

The objective of this research is to prepare and characterize a new and highly efficient polyamide TFC RO membrane by interfacial polymerization in dodecane solvent mixed with co-solvents. Three co-solvents were tested namely; acetone, ethyl acetate, and diethyl ether of concentration of 0.5, 1, 2, 3, and 5 wt %. The modified membranes were characterized by SEM, EDX, AFM and contact angle techniques. The results showed that addition of co-solvent results in a decrease in the roughness, pore size and thickness of the produced membranes. However, as the concentration of the co-solvent increases the pore size of the membranes gets larger. Among the three co-solvents tested, acetone was found to result in membranes with the largest pore size and contact angle followed by diethyl ether then ethyl acetate. Measured contact angle increases as the concentration of the co-solvent increases reaching a constant value except for ethyl acetate where it was found to drop. Investigating flux and salt rejection by the formulated membranes showed that higher flux was attained when acetone was used as a co-solvent followed by diethyl ether then ethyl acetate. However, the highest salt rejection was achieved with diethyl ether.

Cardiac fibroblast transcriptome analyses support a role for interferogenic, profibrotic, and inflammatory genes in anti-SSA/Ro-associated congenital heart block.

Science.gov (United States)

Clancy, Robert M; Markham, Androo J; Jackson, Tanisha; Rasmussen, Sara E; Blumenberg, Miroslav; Buyon, Jill P

2017-09-01

The signature lesion of SSA/Ro autoantibody-associated congenital heart block (CHB) is fibrosis and a macrophage infiltrate, supporting an experimental focus on cues influencing the fibroblast component. The transcriptomes of human fetal cardiac fibroblasts were analyzed using two complementary approaches. Cardiac injury conditions were simulated in vitro by incubating human fetal cardiac fibroblasts with supernatants from macrophages transfected with the SSA/Ro-associated noncoding Y ssRNA. The top 10 upregulated transcripts in the stimulated fibroblasts reflected a type I interferon (IFN) response [e.g., IFN-induced protein 44-like (IFI44L), of MX dynamin-like GTPase (MX)1, MX2, and radical S -adenosyl methionine domain containing 2 (Rsad2)]. Within the fibrotic pathway, transcript levels of endothelin-1 (EDN1), phosphodiesterase (PDE)4D, chemokine (C-X-C motif) ligand (CXCL)2, and CXCL3 were upregulated, while others, including adenomedullin, RAP guanine nucleotide exchange factor 3 (RAPGEF3), tissue inhibitor of metalloproteinase (TIMP)1, TIMP3, and dual specificity phosphatase 1, were downregulated. Agnostic Database for Annotation, Visualization and Integrated Discovery analysis revealed a significant increase in inflammatory genes, including complement C3A receptor 1 (C3AR1), F2R-like thrombin/trypsin receptor 3, and neutrophil cytosolic factor 2. In addition, stimulated fibroblasts expressed high levels of phospho-MADS box transcription enhancer factor 2 [a substrate of MAPK5 (ERK5)], which was inhibited by BIX-02189, a specific inhibitor of ERK5. Translation to human disease leveraged an unprecedented opportunity to interrogate the transcriptome of fibroblasts freshly isolated and cell sorted without stimulation from a fetal heart with CHB and a matched healthy heart. Consistent with the in vitro data, five IFN response genes were among the top 10 most highly expressed transcripts in CHB fibroblasts. In addition, the expression of matrix-related genes

Deposition of reactive nitrogen during the Rocky Mountain Airborne Nitrogen and Sulfur (RoMANS) study

International Nuclear Information System (INIS)

Beem, Katherine B.; Raja, Suresh; Schwandner, Florian M.; Taylor, Courtney; Lee, Taehyoung; Sullivan, Amy P.; Carrico, Christian M.; McMeeking, Gavin R.; Day, Derek; Levin, Ezra; Hand, Jenny; Kreidenweis, Sonia M.; Schichtel, Bret; Malm, William C.; Collett, Jeffrey L.

2010-01-01

Increases in reactive nitrogen deposition are a growing concern in the U.S. Rocky Mountain west. The Rocky Mountain Airborne Nitrogen and Sulfur (RoMANS) study was designed to improve understanding of the species and pathways that contribute to nitrogen deposition in Rocky Mountain National Park (RMNP). During two 5-week field campaigns in spring and summer of 2006, the largest contributor to reactive nitrogen deposition in RMNP was found to be wet deposition of ammonium (34% spring and summer), followed by wet deposition of nitrate (24% spring, 28% summer). The third and fourth most important reactive nitrogen deposition pathways were found to be wet deposition of organic nitrogen (17%, 12%) and dry deposition of ammonia (14%, 16%), neither of which is routinely measured by air quality/deposition networks operating in the region. Total reactive nitrogen deposition during the spring campaign was determined to be 0.45 kg ha -1 and more than doubled to 0.95 kg ha -1 during the summer campaign. - The reactive nitrogen deposition budget for Rocky Mountain National Park.

The role of ro-vibrational coupling in the revival dynamics of diatomic molecular wave packets

International Nuclear Information System (INIS)

Banerji, J; Ghosh, Suranjana

2006-01-01

We study the revival and fractional revivals of a diatomic molecular wave packet of circular states whose weighing coefficients are peaked about a vibrational quantum number ν-bar and a rotational quantum number j-bar. Furthermore, we show that the interplay between the rotational and vibrational motion is determined by a parameter γ =√D/C, where D is the dissociation energy and C is inversely proportional to the reduced mass of the two nuclei. Using I 2 and H 2 as examples, we show, both analytically and visually (through animations), that for γ>>ν-bar, j-bar, the rotational and vibrational time scales are so far apart that the ro-vibrational motion gets decoupled and the revival dynamics depends essentially on one time scale. For γ∼ν-bar, j-bar, on the other hand, the evolution of the wave packet depends crucially on both the rotational and vibrational time scales of revival. In the latter case, an interesting rotational-vibrational fractional revival is predicted and explained

An attempt of using soil grain size in calculating the capacity of water unavailable to plants / Próba wykorzystania uziarnienia gleby do obliczania zawartości wody niedostępnej dla roślin

Directory of Open Access Journals (Sweden)

Brogowski Zygmunt

2015-03-01

Full Text Available Celem pracy była próba znalezienia możliwości obliczenia ilości wody niedostępnej dla roślin na podstawie uziarnienia gleb. Frakcje o średnicach <0,02 mm gromadzą od 90,1 do 98,8% całkowitej ilości wody niedostępnej dla roślin, a frakcja iłu koloidalnego (<0,002 mm zatrzymuje od 52,1 do 80,1% tej wody. Gromadzenie wody we frakcjach <0,02 mm znacząco zależy od ich składu mineralogicznego. Obecność we frakcjach illitu, chlorytu oraz kaolinitu powoduje zmniejszenie ilości wody niedostępnej nawet o 40% w stosunku do frakcji zbudowanych ze smektytów, wermikulitów oraz próchnicy. Ze względu na duże zróżnicowanie ilości wody niedostępnej dla roślin w poszczególnych frakcjach granulometrycznych <0,02 mm wynikaj¹ce ze zróżnicowania mineralogicznego tych frakcji nie udało się wyprowadzić współczynników pozwalających na obliczenie ilościowe w glebach wody niedostępnej dla roślin wiązanej w mikroporach <0,2 μm.

JOINT ECONOMIC AND ENVIRONMENTAL OPTIMIZATION OF HYBRID POWER SUPPLY FOR LARGE SCALE RO-DESALINATION PLANT: WITH AND WITHOUT CO2 SEQUESTRATION

Directory of Open Access Journals (Sweden)

EMAN A. TORA

2016-07-01

Full Text Available In this paper, a multi- objective optimization approach is introduced to define a hybrid power supply system for a large scale RO- desalination plant. The target is to integrate a number of locally available energy resources to generate the electricity demand of the RO- desalination plant with minimizing both the electricity generation cost and the greenhouse gas emissions whereby carbon dioxide sequestration may be an option. The considered energy resources and technologies are wind turbines, solar PV, combined cycles with natural gas turbines, combined cycles with coal gasification, pulverized coal with flue gas desulfurization, and biomass combined heat and power CHP. These variable energy resources are investigated under different constraints on the renewable energy contribution. Likewise, the effect of carbon dioxide sequestration is included. Accordingly, five scenarios have been analyzed. Trade- offs between the minimum electricity generation cost and the minimum greenhouse gas emissions have been determined and represented in Pareto curves using the constraint method (. The results highlight that among the studied fossil fuel technologies, the integrated combined cycle natural gas turbines can provide considerable fraction of the needed power supply. Likewise, wind turbines are the most effective technology among renewable energy options. When CO2 sequestration applied, the costs increase and significant changes in the optimum combination of renewable energy resources have been monitored. In that case, solar PV starts to appreciably compete. The optimum mix of energy resources extends to include biomass CHP as well.

Unravelling Boléro: progressive aphasia, transmodal creativity and the right posterior neocortex.

Science.gov (United States)

Seeley, William W; Matthews, Brandy R; Crawford, Richard K; Gorno-Tempini, Maria Luisa; Foti, Dean; Mackenzie, Ian R; Miller, Bruce L

2008-01-01

Most neurological lesion studies emphasize performance deficits that result from focal brain injury. Here, we describe striking gains of function in a patient with primary progressive aphasia, a degenerative disease of the human language network. During the decade before her language deficits arose, Anne Adams (AA), a lifelong scientist, developed an intense drive to produce visual art. Paintings from AA's artistic peak revealed her capacity to create expressive transmodal art, such as renderings of music in paint, which may have reflected an increased subjective relatedness among internal perceptual and conceptual images. AA became fascinated with Maurice Ravel, the French composer who also suffered from a progressive aphasia, and painted his best-known work, 'Boléro', by translating its musical elements into visual form. Later paintings, achieved when AA was nearly mute, moved towards increasing photographic realism, perhaps because visual representations came to dominate AA's mental landscape during this phase of her illness. Neuroimaging analyses revealed that, despite severe degeneration of left inferior frontal-insular, temporal and striatal regions, AA showed increased grey matter volume and hyperperfusion in right posterior neocortical areas implicated in heteromodal and polysensory integration. The findings suggest that structural and functional enhancements in non-dominant posterior neocortex may give rise to specific forms of visual creativity that can be liberated by dominant inferior frontal cortex injury.

Extending roGFP Emission via Förster-Type Resonance Energy Transfer Relay Enables Simultaneous Dual Compartment Ratiometric Redox Imaging in Live Cells.

Science.gov (United States)

Norcross, Stevie; Trull, Keelan J; Snaider, Jordan; Doan, Sara; Tat, Kiet; Huang, Libai; Tantama, Mathew

2017-11-22

Reactive oxygen species (ROS) mediate both intercellular and intraorganellar signaling, and ROS propagate oxidative stress between cellular compartments such as mitochondria and the cytosol. Each cellular compartment contains its own sources of ROS as well as antioxidant mechanisms, which contribute to dynamic fluctuations in ROS levels that occur during signaling, metabolism, and stress. However, the coupling of redox dynamics between cellular compartments has not been well studied because of the lack of available sensors to simultaneously measure more than one subcellular compartment in the same cell. Currently, the redox-sensitive green fluorescent protein, roGFP, has been used extensively to study compartment-specific redox dynamics because it provides a quantitative ratiometric readout and it is amenable to subcellular targeting as a genetically encoded sensor. Here, we report a new family of genetically encoded fluorescent protein sensors that extend the fluorescence emission of roGFP via Förster-type resonance energy transfer to an acceptor red fluorescent protein for dual-color live-cell microscopy. We characterize the redox and optical properties of the sensor proteins, and we demonstrate that they can be used to simultaneously measure cytosolic and mitochondrial ROS in living cells. Furthermore, we use these sensors to reveal cell-to-cell heterogeneity in redox coupling between the cytosol and mitochondria when neuroblastoma cells are exposed to reductive and metabolic stresses.

The effect of topical application of the platelet-activating factor-antagonist, Ro 24-0238, in psoriasis vulgaris--a clinical and immunohistochemical study.

Science.gov (United States)

Elbers, M E; Gerritsen, M J; van de Kerkhof, P C

1994-11-01

Platelet-activating factor (PAF) is considered to be one of the most potent lipid mediators in allergic and inflammatory reactions. Suggestions that PAF is produced by cutaneous cells, and cells infiltrating the skin from the blood, have been reported. PAF has been identified in allergic cutaneous reactions and also in psoriatic lesions. The biological activity of PAF is thought to be mediated by cell membrane receptors. Studies revealed that PAF-antagonists can be active in animal models of cutaneous inflammation. In humans PAF-antagonists showed minimal therapeutic improvement in studies of antigen-induced cutaneous responses in atopic subjects. No data are available on the effects of PAF-antagonists in psoriasis. The objective of this study was to investigate the effect of a potent PAF-antagonist (Ro 24-0238, 10% solution in diethylene glycol monoethyl ether) in 10 patients with chronic plaque psoriasis, a placebo-controlled double-blind study. Clinical response was evaluated and markers of inflammation, differentiation and proliferation were studied immunohistochemically on punch biopsies taken from actively treated and placebo-treated lesions, before and after treatment. This study demonstrated that a 10% solution of the PAF-antagonist Ro 24-0238 was not effective at the clinical or cell biological level after a 4-week treatment period. The most likely explanation for these negative observations is that PAF is not a significant factor in the pathogenesis of psoriasis.

The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study.

Science.gov (United States)

Mendez, Maria Andreina; Horder, Jamie; Myers, Jim; Coghlan, Suzanne; Stokes, Paul; Erritzoe, David; Howes, Oliver; Lingford-Hughes, Anne; Murphy, Declan; Nutt, David

2013-05-01

GABA (gamma-amino-butyric-acid) is the primary inhibitory neurotransmitter in the human brain. It has been proposed that the symptoms of autism spectrum disorders (ASDs) are the result of deficient GABA neurotransmission, possibly including reduced expression of GABAA receptors. However, this hypothesis has not been directly tested in living adults with ASD. In this preliminary investigation, we used Positron Emission Tomography (PET) with the benzodiazepine receptor PET ligand [(11)C]Ro15-4513 to measure α1 and α5 subtypes of the GABAA receptor levels in the brain of three adult males with well-characterized high-functioning ASD compared with three healthy matched volunteers. We found significantly lower [(11)C]Ro15-4513 binding throughout the brain of participants with ASD (p < 0.0001) compared with controls. Planned region of interest analyses also revealed significant reductions in two limbic brain regions, namely the amygdala and nucleus accumbens bilaterally. Further analysis suggested that these results were driven by lower levels of the GABAA α5 subtype. These results provide initial evidence of a GABAA α5 deficit in ASD and support further investigations of the GABA system in this disorder. This article is part of the Special Issue entitled 'Neurodevelopmental Disorders'. Copyright © 2012 Elsevier Ltd. All rights reserved.

Finding the right RoPax vessel size and freight price. A coste and mode choice model

Energy Technology Data Exchange (ETDEWEB)

Morales Fusco, P.; Grau Sala, M.; Sauri Marchan, S.

2016-07-01

Motorways of the sea operated as RoPax services are natural competitors with only-road freight haulage transportation. Cost, time and quality perceived are the determinants that make transporters and shippers use one route or another. This research considers the role that shipping companies and their ship deployment and pricing strategy have in the equation, as incentives for modal shift from road to sea. A model of the ships and transporter costs is developed considering different business models for the transporter (accompanied versus unaccompanied cargo) followed with a discrete choice model that, once calibrated, allows to test the influence that variables such as frequency, ship size and commercial speed might play into the competitiveness of a shipping line. As a result, different pricing strategies for the shipping line are developed and the characteristics of the optimal shipping line for each of them are found, to either maximize the profit of the shipping company or the modal shift. (Author)

Analysis of different sub-carrier allocation of M-ary QAM-OFDM downlink in RoF system

Science.gov (United States)

Shao, Yu-feng; Chen, Luo; Wang, An-rong; Zhao, Yun-jie; Long, Ying; Ji, Xing-ping

2018-01-01

In this paper, the performance of a 60 GHz radio over fiber (RoF) system with 4/16/64 quadrature amplitude modulation (QAM) orthogonal frequency division multiplexing (OFDM) downstream signals is studied. Delivery of 10 Gbit/s M-ary QAM (MQAM) OFDM signals through the 20-km-long single-mode fiber (SMF) is complicated in terms of intensity modulation and direct detection (IM/DD). Using self-homodyne method, the beating of two independent light waves generating the millimeter-wave at the photodetector can be down-converted to baseband in the electrical domain. Meanwhile, three kinds of sub-carrier arrangement schemes are compared and discussed, and the simulation results show that lower peak-to-average power ratio ( PAPR) can be obtained adopting the adjacent scheme. At bit error rate ( BER) of 10-3, the receiver sensitivity using 4QAM-OFDM sub-carrier signal is almost enhanced by 4 dB and 9 dB compared with those of 16QAM-OFDM signal and 64QAM-OFDM signal.

The Impact of European Traffic Policy and Traffic Routes on the Development of the Ports of Rijeka and Place

Directory of Open Access Journals (Sweden)

Čedomir Ivaković

2006-03-01

Full Text Available Sea ports are the key segment of the traffic and economicdevelopment of maritime countries. Pan-European transportcorridors include the most important sea pmts and sea routes.They are an extension of the existing land corridors.The most important and the most promising crossings oftraffic corridors between the Central European, Pannonianand Adriatic areas, with the naturally shortest traffic routes directedtowards the Croatian sea ports are Corridor 58 ( Rijeka-Zagreb-Budapest and Corridor 5c (Ploce-Sarajevo-Osijek--Budapest. The primary purpose of this work is to study the importanceof the existing trading conditions and new investmentundertakings in the context of increase in competitiveness of theports of Rijeka and Place.The authors' attention is particularly directed to the constructionof new port terminals to increase the traffic potentialsof the Croatian sea ports. The formed conception with its characteristics,the methodology applied, and research results representthe quality starting points in determining a uniform portpolicy of the Republic of Croatia within the European trafficsystem.

A robust statistical estimation (RoSE) algorithm jointly recovers the 3D location and intensity of single molecules accurately and precisely

Science.gov (United States)

Mazidi, Hesam; Nehorai, Arye; Lew, Matthew D.

2018-02-01

In single-molecule (SM) super-resolution microscopy, the complexity of a biological structure, high molecular density, and a low signal-to-background ratio (SBR) may lead to imaging artifacts without a robust localization algorithm. Moreover, engineered point spread functions (PSFs) for 3D imaging pose difficulties due to their intricate features. We develop a Robust Statistical Estimation algorithm, called RoSE, that enables joint estimation of the 3D location and photon counts of SMs accurately and precisely using various PSFs under conditions of high molecular density and low SBR.

Tracing the influence of the Trans-European Suture Zone into the mantle transition zone

Czech Academy of Sciences Publication Activity Database

Knapmeyer-Endrun, B.; Krüger, F.; Legendre, C. P.; Geissler, W.H.; Plomerová, Jaroslava; Babuška, Vladislav; Gaždová, Renata; Jedlička, Petr; Kolínský, Petr; Málek, Jiří; Novotný, Oldřich; Růžek, Bohuslav

2013-01-01

Roč. 363, FEB 1 (2013), s. 73-87 ISSN 0012-821X Institutional support: RVO:67985530 ; RVO:67985891 Keywords : mantle transition zone * Trans-European Suture Zone * East European Craton Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 4.724, year: 2013

SU-E-T-138: Automated Chart Review Module Including Cross-Vendor Data Transfer Verification Developed for IHE-RO Initiative

Energy Technology Data Exchange (ETDEWEB)

Brewer, M; Gordon, C [Franciscan St Margaret Health, Hammond, IN (United States); Tien, C [Community Hospital, Munster, IN (United States)

2015-06-15

Purpose: To follow the Integrating Healthcare Enterprise - Radiation Oncology (IHE-RO) initiative of proper cross-vendor technology integration, an automated chart checker (ACC) was developed. ACC compares extracted data from an approved patient plan in the Eclipse treatment planning system (TPS) against data existing in the Mosaiq treatment management system (TMS). ACC automatically analyzes these parameters using built-in quality checklists to provide further aid in chart review. Methods: Eclipse TPS data are obtained using Eclipse scripting API (ESAPI) while Mosaiq TMS data are obtained from a radiotherapy-treatment-planning (RTP) file. Using this information, ACC identifies TPS-TMS discrepancies in 18 primary beam parameters including MU, energy, jaw positions, gantry angle, table angle, accessories, and bolus for up to 31 beams. Next, approximately 40 items from traditional quality checklists are evaluated such as prescription consistency, DRR graticule placement, plan approval status, global max dose, and dose tracking coefficients. Parameters were artificially modified to determine if ACC would detect an error in data transfer and to test each component of quality checklists. Results: Using ESAPI scripting and RTP file-processing, ACC was able to properly aggregate data from TPS and TMS for up to 31 beams. Errors were artificially introduced into each plan parameter, and ACC was able to successfully detect all of them within seconds. Next, ACC was able to successfully detect mistakes in the chart by identifying deviations with its quality checklists, within seconds. Conclusion: ACC effectively addresses the potential issue of faulty cross-vendor data transfer, as described by IHE-RO. In addition, ACC was also able to detect deviations from its built-in quality checklists. ACC is already an invaluable tool for efficient and standardized chart review and will continue to improve as its incorporated checklists become more comprehensive.

SU-E-T-138: Automated Chart Review Module Including Cross-Vendor Data Transfer Verification Developed for IHE-RO Initiative

International Nuclear Information System (INIS)

Brewer, M; Gordon, C; Tien, C

2015-01-01

Purpose: To follow the Integrating Healthcare Enterprise - Radiation Oncology (IHE-RO) initiative of proper cross-vendor technology integration, an automated chart checker (ACC) was developed. ACC compares extracted data from an approved patient plan in the Eclipse treatment planning system (TPS) against data existing in the Mosaiq treatment management system (TMS). ACC automatically analyzes these parameters using built-in quality checklists to provide further aid in chart review. Methods: Eclipse TPS data are obtained using Eclipse scripting API (ESAPI) while Mosaiq TMS data are obtained from a radiotherapy-treatment-planning (RTP) file. Using this information, ACC identifies TPS-TMS discrepancies in 18 primary beam parameters including MU, energy, jaw positions, gantry angle, table angle, accessories, and bolus for up to 31 beams. Next, approximately 40 items from traditional quality checklists are evaluated such as prescription consistency, DRR graticule placement, plan approval status, global max dose, and dose tracking coefficients. Parameters were artificially modified to determine if ACC would detect an error in data transfer and to test each component of quality checklists. Results: Using ESAPI scripting and RTP file-processing, ACC was able to properly aggregate data from TPS and TMS for up to 31 beams. Errors were artificially introduced into each plan parameter, and ACC was able to successfully detect all of them within seconds. Next, ACC was able to successfully detect mistakes in the chart by identifying deviations with its quality checklists, within seconds. Conclusion: ACC effectively addresses the potential issue of faulty cross-vendor data transfer, as described by IHE-RO. In addition, ACC was also able to detect deviations from its built-in quality checklists. ACC is already an invaluable tool for efficient and standardized chart review and will continue to improve as its incorporated checklists become more comprehensive

U mosta slúžiti. Mezinárodní vědecká konference k 800. výročí založení Řádu kazatelů – dominikánů

Czech Academy of Sciences Publication Activity Database

Vytlačil, Lukáš

2016-01-01

Roč. 53, 2/3 (2016), s. 302-304 ISSN 0018-7003. [U mosta slúžiti. Mezinárodní vědecká konference k 800. výročí založení Řádu kazatelů – dominikánů. Praha, 29.09.2016-30.09.2016] Institutional support: RVO:68378076 Keywords : dominicans * conferences * medieval music * graduals * medieval music theory * Hieronymus de Moravia Subject RIV: AL - Art, Architecture, Cultural Heritage

The Changing Face of European Ports as a Result of their evolving Use since the Nineteenth Century

NARCIS (Netherlands)

H. van Dijk (Henk); M.A. Pinheiro (Magda Avelar)

2003-01-01

textabstractThe aim of this article is to make a comparative study of the history of European ports during the last two centuries showing their complexity and specific characteristics. Whereas during the process of waterfront development, local governments emphasize the relationship of ports with

Morfofisiologia de plantas de milho em competição com picão-preto e trapoeraba submetidas a roçada Morphophysiology of corn plants in competition with picão-preto and trapoeraba submitted to clearings

Directory of Open Access Journals (Sweden)

J.P. Lemos

2012-09-01

Full Text Available Avaliou-se a eficiência do uso de roçadas no controle de picão-preto (Bidens pilosa e trapoeraba (Commelina benghalensis por meio de características morfológicas e fisiológicas do milho. O experimento foi realizado em condições controladas no ano agrícola 2009/2010. As características fisiológicas foram obtidas em parcela subdividida, sendo realizadas quatro avaliações no decorrer do ciclo do milho: 1ª - antes da primeira roçada (V3; 2ª - após a primeira roçada (V6; 3ª - após a segunda roçada (V9; e 4ª - plantas de milho no estádio de florescimento, por meio de um analisador de gases no infravermelho. Duas roçadas reduziram a interferência das plantas daninhas B. pilosa e C. benghalensisnas características morfológicas do milho. A roçada não influenciou os aspectos fisiológicos nas plantas de milho em competição com as plantas daninhas. C. benghalensis causou maior interferência nas características fisiológicas do milho, reduzindo a fotossíntese e a transpiração. A espécie B. pilosa, quando não roçada, apresentou maior capacidade de interferência na morfologia do milho.The efficiency of using clearings to control Picão-preto (Bidens pilosa and Trapoeraba (Commelina benghalensis was evaluated based on the morphological and physiological characteristics of corn. An experiment under greenhouse conditions was conducted in 2009/2010. The physiological characteristics were obtained in a subdivided parcel, with four evaluations being performed throughout the corn cycle (1- before the first clearing (V3; 2- after the first clearing (V6;3- after the second clearing (V9; and 4- corn plants at the fluorescence stage, by means of Infra Red Gas Analyzer. Two clearings reduced the influence of B. pilosa and C. benghalensis weeds on the morphological characteristics of corn. The clearing did not influence the physiological aspects of the corn plants in competition with weeds. C. benghalensis caused a greater

Foreign news and spillovers in emerging European stock markets

Czech Academy of Sciences Publication Activity Database

Hanousek, J.; Kočenda, Evžen

2011-01-01

Roč. 19, č. 1 (2011), s. 170-188 ISSN 0965-7576 Institutional research plan: CEZ:AV0Z70850503 Keywords : emerging European stock market s * foreign news * intraday data Subject RIV: AH - Economics Impact factor: 0.631, year: 2011

Dynamics of 103K/N and 184M/V HIV-1 drug resistant populations: relative comparison in plasma virus RNA versus CD45RO+T cell proviral DNA

DEFF Research Database (Denmark)

Jakobsen, Martin Roelsgaard; Tolstrup, M; Bertelsen, L

2007-01-01

on real-time PCR and amplification refractory mutation system (ARMS). RESULTS: The 103N and 184V mutations were not detected in patients with stable low viremia. Patients previously exposed to mono or dual therapy often carried minor viral populations of either one or both mutations in plasma. The viral......BACKGROUND: Viral populations defined by 103K/N and 184M/V as linked or single mutations in the HIV-1 reverse transcriptase gene were investigated in plasma samples and compared with previous findings in the CD45RO(+)T cell compartment. OBJECTIVE: To develop an ARMS assay for plasma virions...... an unequal distribution of linked-mutation populations in plasma and CD45RO(+)T cells. Furthermore, the linked 103N-184V mutation may be more fit than the single 184V mutation and this linked population emerges rapidly under inadequate drug pressure. Udgivelsesdato: 2007-Jul...

A captive solvent method for rapid N-[11C]methylation of secondary amides: application to the benzodiazepine, 4'-chlorodiazepam (RO5-4864)

International Nuclear Information System (INIS)

Watkins, G.L.; Jewett, D.M.; Mulholland, G.K.; Kilbourn, M.R.; Toorongian, S.A.

1988-01-01

[ 11 C]4'-Chlorodiazepam (RO5-4864), for PET studies of peripheral benzodiazepine receptors, was synthesized by alkylation of 1-desmethyl-4'-chlorodiazepam, in a small volume of acetone adsorbed on acrylic yarn, with [ 11 C]methyl iodide in the injection loop of a liquid chromatograph. The reaction mixture was introduced directly onto a small, disposable alumina chromatographic column. Elution with pentane: ethanol gave a product of high chemical and radiochemical purity. A simple heating and cooling device for the injection loop is described. (author)

Inflation convergence within the European Union: a panel data analysis

Czech Academy of Sciences Publication Activity Database

Kočenda, Evžen; Papell, D. H.

1997-01-01

Roč. 2, č. 3 (1997), s. 189-198 ISSN 1076-9307 Keywords : inflation convergence * European Union * panel data Subject RIV: AH - Economics http://search.ebscohost.com/login.aspx?direct=true&db=bth&AN=16616418&site=ehost-live

Restrição ao uso de substâncias perigosas (RoHS) no segmento de computadores pessoais: análise da estratégia de adoção pelos fabricantes estabelecidos no Brasil

OpenAIRE

Brescansin, Ademir

2014-01-01

A publicação, em 2003, da diretiva europeia limitando o uso das substâncias perigosas (chumbo, mercúrio, cádmio, cromo hexavalente e retardantes de chama à base de bromo) RoHS (Restriction of Hazardous Substances) obrigou os fabricantes a adequarem seus produtos e processos para atendimento à legislação. Muitas empresas fabricantes de equipamentos eletroeletrônicos, a partir de então, passaram a adotar os requisitos da RoHS para todos os seus produtos. No Brasil mesmo não existindo uma legisl...

The European dimension for the mouse genome mutagenesis

Czech Academy of Sciences Publication Activity Database

Auwerx, J.; Avner, P.; Baldock, R.; Ballabio, A.; Balling, R.; Barbacid, M.; Berns, A.; Bradley, A.; Brown, S.; Carmeliet, P.; Chambon, P.; Cox, R.; Davidson, D.; Davies, K.; Duboule, D.; Forejt, Jiří; Granucci, F.; Hastie, N.; Angelis, M. H. de; Jackson, I.; Kioussis, D.; Kollias, G.; Lathrop, M.; Lendahl, U.; Malumbres, M.; von Melchner, H.; Müller, W.; Partanen, J.; Ricciardi-Castagnoli, P.; Rigby, P.; Rosen, B.; Rosenthal, N.; Skarnes, B.; Stewart, A. F.; Thornton, J.; Tocchini-Valentini, G.; Wagner, E.; Wahli, W.; Wurst, W.

2004-01-01

Roč. 16, - (2004), s. 925-927 ISSN 1061-4036 R&D Projects: GA MŠk(CZ) LN00A079 Institutional research plan: CEZ:AV0Z5052915 Keywords : The European Mouse Mutagenesis Consortium Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 24.695, year: 2004

ÜRO siirdehinna määramise praktiline juhend arenguriikidele - kas vääriline kaitse arenguriikide maksubaasile? : [bakalaureusetöö] / Jana Tali ; Tartu Ülikool, õigusteaduskond ; juhendaja: Lasse Lehis

Index Scriptorium Estoniae

Tali, Jana, 1977-

2013-01-01

Turuväärtuse põhimõtte algupärast ja kujunemisest rahvusvaheliseks normiks, praeguse süsteemi tugevatest ja nõrkadest külgedest, ÜRO siirdehinna määramise praktilisest juhendist arenguriikidele (UNTPM)

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries

International Nuclear Information System (INIS)

Lindner, Oliver; Burchert, Wolfgang; Pascual, Thomas N.B.; Kashyap, Ravi; Dondi, Maurizio; Paez, Diana; Mercuri, Mathew; Acampa, Wanda; Flotats, Albert; Kaufmann, Philipp A.; Kitsiou, Anastasia; Knuuti, Juhani; Underwood, S.R.; Vitola, Joao V.; Mahmarian, John J.; Karthikeyan, Ganesan; Better, Nathan; Rehani, Madan M.; Einstein, Andrew J.

2016-01-01

Nuclear cardiology is widely used to diagnose coronary artery disease and to guide patient management, but data on current practices, radiation dose-related best practices, and radiation doses are scarce. To address these issues, the IAEA conducted a worldwide study of nuclear cardiology practice. We present the European subanalysis. In March 2013, the IAEA invited laboratories across the world to document all SPECT and PET studies performed in one week. The data included age, gender, weight, radiopharmaceuticals, injected activities, camera type, positioning, hardware and software. Radiation effective dose was calculated for each patient. A quality score was defined for each laboratory as the number followed of eight predefined best practices with a bearing on radiation exposure (range of quality score 0 - 8). The participating European countries were assigned to regions (North, East, South, and West). Comparisons were performed between the four European regions and between Europe and the rest-of-the-world (RoW). Data on 2,381 European patients undergoing nuclear cardiology procedures in 102 laboratories in 27 countries were collected. A cardiac SPECT study was performed in 97.9 % of the patients, and a PET study in 2.1 %. The average effective dose of SPECT was 8.0 ± 3.4 mSv (RoW 11.4 ± 4.3 mSv; P < 0.001) and of PET was 2.6 ± 1.5 mSv (RoW 3.8 ± 2.5 mSv; P < 0.001). The mean effective doses of SPECT and PET differed between European regions (P < 0.001 and P = 0.002, respectively). The mean quality score was 6.2 ± 1.2, which was higher than the RoW score (5.0 ± 1.1; P < 0.001). Adherence to best practices did not differ significantly among the European regions (range 6 to 6.4; P = 0.73). Of the best practices, stress-only imaging and weight-adjusted dosing were the least commonly used. In Europe, the mean effective dose from nuclear cardiology is lower and the average quality score is higher than in the RoW. There is regional variation in effective dose in

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries

Energy Technology Data Exchange (ETDEWEB)

Lindner, Oliver; Burchert, Wolfgang [University Hospital of the Ruhr University, Institute of Radiology, Nuclear Medicine and Molecular Imaging, Heart and Diabetes Center North Rhine-Westphalia Bochum, Bad Oeynhausen (Germany); Pascual, Thomas N.B.; Kashyap, Ravi; Dondi, Maurizio; Paez, Diana [International Atomic Energy Agency, Section of Nuclear Medicine and Diagnostic Imaging, Division of Human Health, Vienna (Austria); Mercuri, Mathew [Columbia University Medical Center and New York-Presbyterian Hospital, Division of Cardiology, Department of Medicine, New York, NY (United States); Acampa, Wanda [National Council of Research, Institute of Biostructures and Bioimaging, Naples (Italy); Flotats, Albert [Universitat Autonoma de Barcelona, Nuclear Medicine Department, Hospital de la Santa Creu i Sant Pau, Barcelona (Spain); Kaufmann, Philipp A. [University Hospital Zurich, Department of Nuclear Medicine and Cardiac Imaging, Zurich (Switzerland); Kitsiou, Anastasia [Sismanoglio Hospital, Department of Cardiology, Athens (Greece); Knuuti, Juhani [University of Turku, and Turku University Hospital, Turku PET Centre, Turku (Finland); Underwood, S.R. [Imperial College London, National Heart and Lung Institute, London (United Kingdom); Royal Brompton and Harefield Hospitals, Department of Nuclear Medicine, London (United Kingdom); Vitola, Joao V. [Quanta Diagnostico and Terapia, Curitiba (Brazil); Mahmarian, John J. [Houston Methodist DeBakey Heart and Vascular Center, Department of Cardiology, Houston, TX (United States); Karthikeyan, Ganesan [All India Institute of Medical Sciences, Department of Cardiology, New Delhi (India); Better, Nathan [Royal Melbourne Hospital and University of Melbourne, Department of Nuclear Medicine, Melbourne (Australia); Rehani, Madan M. [International Atomic Energy Agency, Radiation Protection of Patients Unit, Vienna (Austria); Massachusetts General Hospital and Harvard Medical School, Department of Radiology, Boston, MA (United States); Einstein, Andrew J. [Columbia University Medical Center and New York-Presbyterian Hospital, Division of Cardiology, Department of Medicine, New York, NY (United States); Columbia University Medical Center and New York-Presbyterian Hospital, Department of Radiology, New York, NY (United States); Collaboration: for the INCAPS Investigators Group

2016-04-15

Nuclear cardiology is widely used to diagnose coronary artery disease and to guide patient management, but data on current practices, radiation dose-related best practices, and radiation doses are scarce. To address these issues, the IAEA conducted a worldwide study of nuclear cardiology practice. We present the European subanalysis. In March 2013, the IAEA invited laboratories across the world to document all SPECT and PET studies performed in one week. The data included age, gender, weight, radiopharmaceuticals, injected activities, camera type, positioning, hardware and software. Radiation effective dose was calculated for each patient. A quality score was defined for each laboratory as the number followed of eight predefined best practices with a bearing on radiation exposure (range of quality score 0 - 8). The participating European countries were assigned to regions (North, East, South, and West). Comparisons were performed between the four European regions and between Europe and the rest-of-the-world (RoW). Data on 2,381 European patients undergoing nuclear cardiology procedures in 102 laboratories in 27 countries were collected. A cardiac SPECT study was performed in 97.9 % of the patients, and a PET study in 2.1 %. The average effective dose of SPECT was 8.0 ± 3.4 mSv (RoW 11.4 ± 4.3 mSv; P < 0.001) and of PET was 2.6 ± 1.5 mSv (RoW 3.8 ± 2.5 mSv; P < 0.001). The mean effective doses of SPECT and PET differed between European regions (P < 0.001 and P = 0.002, respectively). The mean quality score was 6.2 ± 1.2, which was higher than the RoW score (5.0 ± 1.1; P < 0.001). Adherence to best practices did not differ significantly among the European regions (range 6 to 6.4; P = 0.73). Of the best practices, stress-only imaging and weight-adjusted dosing were the least commonly used. In Europe, the mean effective dose from nuclear cardiology is lower and the average quality score is higher than in the RoW. There is regional variation in effective dose in

Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38(MAPK) inhibitor RO3201195 for study in Werner syndrome cells.

Science.gov (United States)

Bagley, Mark C; Davis, Terence; Dix, Matthew C; Murziani, Paola G S; Rokicki, Michal J; Kipling, David

2008-07-01

5-Aminopyrazol-4-yl ketones are prepared rapidly and efficiently using microwave dielectric heating from beta-ketonitriles by treatment with N,N'-diphenylformamidine followed by heterocyclocondensation by irradiation with a hydrazine. The inhibitory activity of RO3201195 prepared by this methodology was confirmed in hTERT-immortalized HCA2 and WS dermal fibroblasts at 200nM concentration, both by ELISA and immunoblot assay, and displays excellent kinase selectivity for p38alpha MAPK over the related stress-activated kinase JNK.

Global (50°S–50°N) distribution of water vapor observed by COSMIC GPS RO: Comparison with GPS radiosonde, NCEP, ERA-Interim, and JRA-25 reanalysis data sets

CSIR Research Space (South Africa)

Kishore, P

2011-08-01

Full Text Available In this study, global (50°S–50°N) distribution of water vapor is investigated using COSMIC GPS RO measurements. Detailed comparisons have been made between COSMIC and high resolution GPS radiosonde measurements across 13 tropical stations and model...

Variations in Tropospheric Submicron Particle Size Distributions Across the European Continent 2008–2009

Czech Academy of Sciences Publication Activity Database

Beddows, D.C.S.; Dall’Osto, M.; Harrison, R. M.; Kulmala, M.; Asmi, A.; Wiedensohler, A.; Laj, P.; Fjaeraa, A.M.; Sellegri, K.; Birmili, W.; Bukowiecki, N.; Weingartner, E.; Baltensperger, U.; Ždímal, Vladimír; Zíková, Naděžda; Putaud, J.-P.; Marinoni, A.; Tunved, P.; Hansson, H.-C.; Feibig, M.; Kivekäs, N.; Swietlicki, E.; Lihavainen, H.; Asmi, E.; Ulevicius, V.; Aalto, P.P.; Mihalopoulos, N.; Kalivitis, N.; Kalapov, I.; Kiss, G.; de Leeuw, G.; Henzing, B.; O'Dowd, C.; Jennings, S.G.; Flentje, H.; Meinhardt, F.; Ries, L.; Denier van der Gon19, H.A.C.; Visschedijk, A.J.H.; Swietlicki, E.

2014-01-01

Roč. 14, č. 8 (2014), s. 4327-4348 ISSN 1680-7316 EU Projects: European Commission(XE) 36833 - EUCAARI; European Commission(XE) 26140 - EUSAAR Institutional support: RVO:67985858 Keywords : particle size distribution * clusters * aerosol size distribution Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 5.053, year: 2014

OLAYIWOLA, RO

African Journals Online (AJOL)

ADOWIE PERE

special applications. Our lives have ... solution is found for the reactive layer in the presence of very ... depend on the space variable x and we impose the adiabatic boundary conditions on the temperatures. Thus, the .... Theorem 1: Let δσα α α.

Transformações no sistema tradicional de roça itinerante na Mata Atlântica do litoral sul brasileiro

Directory of Open Access Journals (Sweden)

Nicole Rodrigues Vicente

2014-12-01

Full Text Available http://dx.doi.org/10.5007/1807-1384.2014v11n2p183 Este artigo visa compreender as mudanças ocorridas no sistema tradicional de roça itinerante no litoral de Santa Catarina ao longo das últimas quatro décadas. A pesquisa foi desenvolvida junto a agricultores tradicionais moradores de duas microbacias hidrográficas do município de Biguaçu-SC. A unidade amostral foi a propriedade onde reside o informante-chave, selecionado via Bola-de-Neve. Foram conduzidas entrevistas semiestruturadas, observações participante e turnês-guiadas para coleta de dados. A análise de dados se deu por meio do software Atlas.ti, de estatística descritiva e análise multivariada de Componentes Principais. Os dados foram interpretados com base na linha histórica de ocorrência. A pesquisa diagnosticou que o manejo realizado pela população local se fundamenta na condução periódica de cultivos agrícolas e florestais, num sistema de rotação com períodos de pousio. As principais culturas agrícolas utilizadas eram a mandioca, a banana, o milho, o café e a cana-de-açúcar, mas atualmente apenas a mandioca tem forte expressão. Para todas as fases de desenvolvimento do manejo os agricultores apresentam conhecimentos específicos de leitura da paisagem e da dinâmica florestal. Mudanças nas políticas agrícolas e gestão das florestas nativas têm afetado diretamente o sistema de roça itinerante nas microbacias estudadas. A população local apresenta relação intrínseca com os recursos florestais nativos devendo ter seu modo de vida respeitado e seu sistema tradicional valorizado.

Léčení a léčitelství v lidové tradici, 24-25. září 2014, Rožnov pod Radhoštěm

Czech Academy of Sciences Publication Activity Database

Motyčková, Dana

2014-01-01

Roč. 101, č. 4 (2014), s. 485-487 ISSN 0009-0794 Institutional support: RVO:68378076 Keywords : workshop * folk medicine * folk tradition * ways of healing * healers. Subject RIV: AC - Archeology, Anthropology, Ethnology Impact factor: 0.094, year: 2012

Análise econômica de sistemas agroflorestais na Amazônia ocidental, Machadinho d'Oeste- RO Economic analysis of agroforestry systems in eastern Amazonia, Machadinho d'Oeste- RO, Brazil

Directory of Open Access Journals (Sweden)

Michelliny de Matos Bentes-Gama

2005-06-01

Full Text Available O objetivo deste estudo foi realizar a análise financeira e a simulação de risco de investimento em sistemas agroflorestais (SAFs implantados em 1987, no Campo Experimental da Embrapa Rondônia, localizado no município de Machadinho d'Oeste, RO. A análise financeira foi realizada mediante os métodos de avaliação de projetos florestais, e para a análise de risco utilizou-se a técnica de simulação de Monte Carlo, mediante o programa @RISK. Entre os arranjos testados, o SAF T1 Castanha-do-brasil-banana-pimenta-do-reino-cupuaçu apresentou o melhor desempenho financeiro em relação aos SAFs T2 Freijó-banana-pimenta-do-reino-cupuaçu e T3 Pupunha-banana-pimenta-do-reino-cupuaçu . Os custos com tratos culturais e colheita representaram mais de 70% da composição dos custos totais, e a participação da mão-de-obra foi superior a 50% nas fases de preparo da área e de manutenção (tratos culturais dos SAFs. A simulação da análise de risco indicou que as variáveis que afetaram o Valor Presente Líquido no Horizonte Infinito (VPL*, de acordo com a ordem de importância (R, foram: taxa de desconto, preço do fruto de cupuaçu (Theobroma grandiflorum, custo de colheita, preço da madeira de castanha-do-brasil (Bertholletia excelsa e o custo de tratos culturais. Apesar do alto custo de implantação e manutenção, o SAF T1 apresentou uma probabilidade de 15% de os valores do Valor Presente Líquido (VPL se concentrarem em torno de R$35.000 ha-1.ano-1.The objective of this study was to carry out the financial analysis and the risk of investment simulation in agroforestry systems (AFSs established in 1987 in the Experimental Field of Embrapa Rondônia, located in the County of Machadinho d'Oeste, RO. Financial analysis was made through the evaluation of results from the forestry enterprise evaluation methods, and the risk analysis was carried out through the Monte Carlo simulation technique by @RISK software. Among the arrangements

Urban Environment in European Big Cities

Czech Academy of Sciences Publication Activity Database

Vaishar, Antonín; Cetkovský, Stanislav; Kallabová, Eva; Klusáček, Petr; Kolibová, Barbora; Lacina, Jan; Mikulík, Oldřich; Zapletalová, Jana

2006-01-01

Roč. 14, č. 1 (2006), s. 46-62 ISSN 1210-8812 Grant - others:EU(XE) EVK4-CT-2002-00086 Institutional research plan: CEZ:AV0Z3086906 Keywords : European big cities * urban environment * reurbanisation * životní prostředí * Bologna * Ljubljana * León * Brno * Leipzig Subject RIV: DE - Earth Magnetism, Geodesy, Geography

« Les usages sociaux de la Bible ». Numéro de la revue Médiévales

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Dominique Iogna-Prat

2007-08-01

Full Text Available L’ambition de ce numéro de Médiévales, qui donnera d’abord lieu à un Atelier à Auxerre les 16 et 17 novembre 2007, consiste à rendre compte des recherches actuelles sur la Bible et l’exégèse au Moyen Âge, dans une double direction : Les exploitations sociales et « politiques » de la Bible, telles qu’on peut les saisir à travers les commentaires et l’utilisation des figures bibliques au fil des siècles. Ce type d’étude s’inscrit dans la lignée d’un certain nombre de travaux anglo-saxons et ita...

Czech-German Cross-Border Cooperation in the enlarged European Union

Czech Academy of Sciences Publication Activity Database

Houžvička, Václav

2005-01-01

Roč. 3, č. 1 (2005), s. 1-3 ISSN 1214-7567 R&D Projects: GA AV ČR(CZ) IBS7028301 Institutional research plan: CEZ:AV0Z70280505 Keywords : European Union * local elites * cross/border cooperation Subject RIV: AO - Sociology, Demography

Preservation of peripheral benzodiazepine receptors: differential effects of freezing on [3H]Ro 5-4864 and [3H]PK 11195 binding

International Nuclear Information System (INIS)

Basile, A.S.; Ostrowski, N.L.; Skolnick, P.

1987-01-01

A statistically significant decrease in the density of peripheral benzodiazepine receptors was observed in renal membranes of rats beginning 2 weeks after adrenalectomy when compared with sham-operated controls. This decrease in peripheral benzodiazepine receptor density was manifest as a decrease in the Bmax of two ligands [ 3 H]Ro 5-4864 and [ 3 H]PK 11195, without accompanying changes in their apparent affinity (Kd) for this site. Similar changes were not seen in another aldosterone-sensitive organ, the submandibular salivary gland. The decrease in peripheral benzodiazepine receptor density in observed in adrenalectomized rat renal membranes was restored to control levels after 1 week of aldosterone administration using a dose (12.5 micrograms/kg/day) that had no effect on peripheral benzodiazepine receptor density in sham-operated animals. In contrast, dexamethasone administration (50 micrograms/kg/day, 1 week) had no effect on renal peripheral benzodiazepine receptor density when administered to either adrenalectomized or sham-operated rats. Further, adrenal demedullation had no effect on renal peripheral benzodiazepine receptor density or affinity. The decrease in peripheral benzodiazepine receptor density was localized to the renal cortex and the outer stripe of the medulla by gross dissection of renal slices and renal tissue section autoradiography. The specific effect of adrenalectomy on renal peripheral benzodiazepine receptor density, the lack of direct effect of aldosterone on [ 3 H]Ro 5-4864 binding, and the localization of the change in peripheral benzodiazepine receptor density to the renal cortex and outer stripe suggests that these changes may reflect an adaptation of the renal nephron (possibly the distal convoluted tubule, intermediate tubule and/or the collecting duct) to the loss of mineralocorticoid hormones

Impact of Mining Activity upon Environment in Roşia Montană

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SIGISMUND DUMA

2008-01-01

Full Text Available Roşia Montană is the greatest gold ore in Romania and one of the greatest in Europe, and its exploitation has been carried out since Antiquity up to nowadays. If the traditional extraction and processing technologies had a minimal impact upon environment, the ones adopted in modern times have affected all the components of the natural environment. In the perspective of capitalizing the gold ore through the programme elaborated by the Canadian company, Gold Corporation, the zonal geographical space will be degraded up to the level of industrial dessert over an area of 100 km2 and in case of damage, the affected area can extend enormously. The environmental problems are related both to the specific nature of such an industrial activity and, especially, to the use of enormous quantities of sodium cyanide directly on the preparation flux from the industrial plant. Few such cases are known worldwide, in several economically less developed countries. Usually, cyanides are used for treating the gold concentrations, operation done in conditions of maximum security, in closed spaces, situated in isolated zones and the neutralization (detoxification of cyanides is done in situ. The treatment of cyanides in open spaces has always generated environmental problems. Moreover, none of the cyanide treatment technologies eliminates entirely their toxic effect (less toxic chemical products are obtained. In order to avoid the production of an environmental disaster and to preserve the local patrimony values (in this place there lies the richest mining archeological site in Europe, we elaborated several recommendations we consider feasible as they allow both the capitalization of ore, which is a socio-economic necessity of the area, and the ecological reconstruction of the affected geographical space.

Historická slavistika na stránkách sta ročníků Slovanského přehledu, Tradice - současnost - perspektivy

Czech Academy of Sciences Publication Activity Database

Vlček, Radomír

2016-01-01

Roč. 19, č. 2 (2016), s. 155-166 ISSN 1212-1509 Institutional support: RVO:67985963 Keywords : Slavonic review * history of science * Slavonic studies * historical Slavonic studies * history of Slavonic studies Subject RIV: AB - History OBOR OECD: History (history of science and technology to be 6.3, history of specific science s to be under the respective headings)

Accurate Quantum Wave Packet Study of the Deep Well D+ + HD Reaction: Product Ro-vibrational State-Resolved Integral and Differential Cross Sections.

Science.gov (United States)

He, Haixiang; Zhu, Weimin; Su, Wenli; Dong, Lihui; Li, Bin

2018-03-08

The H + + H 2 reaction and its isotopic variants as the simplest triatomic ion-molecule reactive system have been attracting much interests, however there are few studies on the titled reaction at state-to-state level until recent years. In this work, accurate state-to-state quantum dynamics studies of the titled reaction have been carried out by a reactant Jacobi coordinate-based time-dependent wave packet approach on diabatic potential energy surfaces constructed by Kamisaka et al. Product ro-vibrational state-resolved information has been calculated for collision energies up to 0.2 eV with maximal total angular momentum J = 40. The necessity of including all K-component for accounting the Coriolis coupling for the reaction has been illuminated. Competitions between the two product channels, (D + + HD' → D' + + HD and D + + HD' → H + + DD') were investigated. Total integral cross sections suggest that resonances enhance the reactivity of channel D + + HD'→ H + + DD', however, resonances depress the reactivity of the another channel D + + HD' → D' + + HD. The structures of the differential cross sections are complicated and depend strongly on collision energies of the two channels and also on the product rotational states. All of the product ro-vibrational state-resolved differential cross sections for this reaction do not exhibit rigorous backward-forward symmetry which may indicate that the lifetimes of the intermediate resonance complexes should not be that long. The dynamical observables of this deuterated isotopic reaction are quite different from the reaction of H + + H 2 → H 2 + H + reported previously.

Synthesis of robust and high-performance aquaporin-based biomimetic membranes by interfacial polymerization-membrane preparation and RO performance characterization

DEFF Research Database (Denmark)

Zhao, Yang; Qiu, Changquan; Li, Xuesong

2012-01-01

-free ABMs that can be easily scaled up. In the current study, a thin film composite (TFC) ABM was prepared by the interfacial polymerization method, where AquaporinZ-containing proteoliposomes were added to the m-phenylene-diamine aqueous solution. Control membranes, either without aquaporins......Aquaporins are water channel proteins with excellent water permeability and solute rejection, which makes them promising for preparing high-performance biomimetic membranes. Despite the growing interest in aquaporin-based biomimetic membranes (ABMs), it is challenging to produce robust and defect...... or with inactive (mutant) aquaporins, were also similarly prepared. The separation performance of these membranes was evaluated by cross-flow reverse osmosis (RO) tests. Compared to the controls, the active ABM achieved significantly higher water permeability (∼4L/m2hbar) with comparable NaCl rejection (∼97...

Construction of a dead-end type micro- to R.O. membrane test cell and performance test with the laboratory- made and commercial membranes

Directory of Open Access Journals (Sweden)

Darunee Bhongsuwan

2002-11-01

Full Text Available A dead-end type membrane stirred cell for an RO filtration test has been designed and constructed. Magnetic stirring system is applied to overcome a pressure-induced concentration polarization occurred over a membrane surface in the test cell. A high pressure N2 tank is used as a pressure source.Feed container is designed for 2.5 l feed solution and a stirred cell volume is 0.5 l . The test cell holds a magnetic stirrer freely moved over the membrane surface. All units are made of stainless steel. A porous SS316L disc is used as a membrane support. The dead-end stirred cell is tested to work properly in an operating pressure ranged 0 - 400 psi. It means that the dead-end cell can be used to test a membrane of different filtration modes, from micro- to Reverse Osmosis filtration. Tests performed at 400 psi for 3 hours are safe but tests at a 500 psi increase leakage possibility. The cell is used to test the performance of both commercial and laboratory-made membranes. It shows that the salt rejection efficiency of the nano- and RO membranes, NTR759HR and LES90, determined by using the new test cell, is closely similar to those reported from the manufacture. Result of the tests for our own laboratory-made membrane shows a similar performance to the nanofiltration membrane LES90.

Models of red giants in the CoRoT asteroseismology fields combining asteroseismic and spectroscopic constraints - The open cluster NGC 6633 and field stars-

Science.gov (United States)

Lagarde, Nadège; Miglio, Andrea; Eggenberger, Patrick; Morel, Thierry; Montalbàn, Josefina; Mosser, Benoit

2015-08-01

The availability of asteroseismic constraints for a large sample of red giant stars from the CoRoT and Kepler missions paves the way for various statistical studies of the seismic properties of stellar populations.We use the first detailed spectroscopic study of CoRoT red-giant stars (Morel et al 2014) to compare theoretical stellar evolution models to observations of the open cluster NGC 6633 and field stars.In order to explore the effects of rotation-induced mixing and thermohaline instability, we compare surface abundances of carbon isotopic ratio and lithium with stellar evolution predictions. These chemicals are sensitive to extra-mixing on the red-giant branch.We estimate mass, radius, and distance for each star using the seismic constraints. We note that the Hipparcos and seismic distances are different. However, the uncertainties are such that this may not be significant. Although the seismic distances for the cluster members are self consistent they are somewhat larger than the Hipparcos distance. This is an issue that should be considered elsewhere. Models including thermohaline instability and rotation-induced mixing, together with the seismically determined masses can explain the chemical properties of red-giants targets. Tighter constraints on the physics of the models would be possible if there were detailed knowledge of the core rotation rate and the asymptotic period spacing.

Regrowth and radiation sensitivity of quiescent cells isolated from EMT6/Ro-fed plateau monolayers

International Nuclear Information System (INIS)

Luk, C.K.; Keng, P.C.; Sutherland, R.M.

1985-01-01

A quiescent [denoted as Q(G0/G1)] subpopulation was isolated from EMT6/Ro-fed plateau monolayers by centrifugal elutriation. The median Coulter volume of these cells was significantly smaller than that of the original population from which they were elutriated. Using two-step acridine orange staining and dual parameter flow cytometric analysis, over 95% of quiescent cells were found to have G1 DNA content, and 80% of the cells had a decreased RNA content as compared to rapidly proliferating exponential G1 cells. After labeling for 24 hr (two doubling times) with [ 3 H]thymidine, less than 2% of the quiescent cells incorporated [3H]thymidine as measured by autoradiography. The colony-forming efficiency of these cells was not significantly different from that of exponential cells. When such Q(G0/G1) cells were replated in fresh medium at a lower density, there was a lag time of 30 hr before any increase in cell number was detected, after which the cell-doubling rate matched that of exponential culture. Results obtained from the radiation dose-response curves showed that quiescent (G0/G1) cells were more radiosensitive than exponential G1 or unseparated fed plateau cells

Sensitivity of European wheat to extreme weather

Czech Academy of Sciences Publication Activity Database

Mäkinen, H.; Kaseva, J.; Trnka, Miroslav; Balek, Jan; Kersebaum, K. C.; Nendel, C.; Gobin, A.; Olesen, J. E.; Bindi, M.; Ferrise, R.; Moriondo, M.; Rodríguez, A.; Ruiz-Ramos, M.; Takáč, J.; Bezák, P.; Ventrella, D.; Ruget, F.; Capellades, G.; Kahiluoto, H.

2018-01-01

Roč. 222, jun (2018), s. 209-217 ISSN 0378-4290 R&D Projects: GA MŠk(CZ) LO1415; GA MZe(CZ) QJ1610072 Institutional support: RVO:86652079 Keywords : Climate change * Cultivar * European wheat * Extreme * Weather * Yield response Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 3.048, year: 2016

Nuclear cardiology practice and associated radiation doses in Europe: results of the IAEA Nuclear Cardiology Protocols Study (INCAPS) for the 27 European countries.

Science.gov (United States)

Lindner, Oliver; Pascual, Thomas N B; Mercuri, Mathew; Acampa, Wanda; Burchert, Wolfgang; Flotats, Albert; Kaufmann, Philipp A; Kitsiou, Anastasia; Knuuti, Juhani; Underwood, S Richard; Vitola, João V; Mahmarian, John J; Karthikeyan, Ganesan; Better, Nathan; Rehani, Madan M; Kashyap, Ravi; Dondi, Maurizio; Paez, Diana; Einstein, Andrew J

2016-04-01

Nuclear cardiology is widely used to diagnose coronary artery disease and to guide patient management, but data on current practices, radiation dose-related best practices, and radiation doses are scarce. To address these issues, the IAEA conducted a worldwide study of nuclear cardiology practice. We present the European subanalysis. In March 2013, the IAEA invited laboratories across the world to document all SPECT and PET studies performed in one week. The data included age, gender, weight, radiopharmaceuticals, injected activities, camera type, positioning, hardware and software. Radiation effective dose was calculated for each patient. A quality score was defined for each laboratory as the number followed of eight predefined best practices with a bearing on radiation exposure (range of quality score 0 - 8). The participating European countries were assigned to regions (North, East, South, and West). Comparisons were performed between the four European regions and between Europe and the rest-of-the-world (RoW). Data on 2,381 European patients undergoing nuclear cardiology procedures in 102 laboratories in 27 countries were collected. A cardiac SPECT study was performed in 97.9 % of the patients, and a PET study in 2.1 %. The average effective dose of SPECT was 8.0 ± 3.4 mSv (RoW 11.4 ± 4.3 mSv; P cardiology is lower and the average quality score is higher than in the RoW. There is regional variation in effective dose in relation to the best practice quality score. A possible reason for the differences between Europe and the RoW could be the safety culture fostered by actions under the Euratom directives and the implementation of diagnostic reference levels. Stress-only imaging and weight-adjusted activity might be targets for optimization of European nuclear cardiology practice.

Validation of MIPAS IMK/IAA V5R_O3_224 ozone profiles

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A. Laeng

2014-11-01

Full Text Available We present the results of an extensive validation program of the most recent version of ozone vertical profiles retrieved with the IMK/IAA (Institute for Meteorology and Climate Research/Instituto de Astrofísica de Andalucía MIPAS (Michelson Interferometer for Passive Atmospheric Sounding research level 2 processor from version 5 spectral level 1 data. The time period covered corresponds to the reduced spectral resolution period of the MIPAS instrument, i.e., January 2005–April 2012. The comparison with satellite instruments includes all post-2005 satellite limb and occultation sensors that have measured the vertical profiles of tropospheric and stratospheric ozone: ACE-FTS, GOMOS, HALOE, HIRDLS, MLS, OSIRIS, POAM, SAGE II, SCIAMACHY, SMILES, and SMR. In addition, balloon-borne MkIV solar occultation measurements and ground-based Umkehr measurements have been included, as well as two nadir sensors: IASI and SBUV. For each reference data set, bias determination and precision assessment are performed. Better agreement with reference instruments than for the previous data version, V5R_O3_220 (Laeng et al., 2014, is found: the known high bias around the ozone vmr (volume mixing ratio peak is significantly reduced and the vertical resolution at 35 km has been improved. The agreement with limb and solar occultation reference instruments that have a known small bias vs. ozonesondes is within 7% in the lower and middle stratosphere and 5% in the upper troposphere. Around the ozone vmr peak, the agreement with most of the satellite reference instruments is within 5%; this bias is as low as 3% for ACE-FTS, MLS, OSIRIS, POAM and SBUV.

The European Logarithmic Microprocessor

Czech Academy of Sciences Publication Activity Database

Coleman, J. N.; Softley, C. I.; Kadlec, Jiří; Matoušek, R.; Tichý, Milan; Pohl, Zdeněk; Heřmánek, Antonín; Benschop, N. F.

2008-01-01

Roč. 57, č. 4 (2008), s. 532-546 ISSN 0018-9340 Grant - others:Evropská komise(BE) ESPRIT 33544 Institutional research plan: CEZ:AV0Z10750506 Source of funding: R - rámcový projekt EK Keywords : Processor architecture * arithmetic unit * logarithmic arithmetic Subject RIV: JC - Computer Hardware ; Software Impact factor: 2.611, year: 2008 http://library.utia.cas.cz/separaty/2008/ZS/kadlec-the%20european%20logarithmic%20microprocessor.pdf

Duchovní hudba – Hudba slovanské vzájemnosti – Hudba po roce 1989, výroční konference České společnosti pro hudební vědu, o. s., Praha 29.–30. 11. 2013

Czech Academy of Sciences Publication Activity Database

Gabrielová, Jarmila; Vozková, Jana

2014-01-01

Roč. 51, 1-2 (2014), s. 203-205 ISSN 0018-7003. [Duchovní hudba – Hudba slovanské vzájemnosti – Hudba 203 po roce 1989, výroční konference České společnosti pro hudební vědu, o. s. Praha, 29.-30.11.2013] Institutional support: RVO:68378076 Keywords : musicological conference * conference report Subject RIV: AL - Art, Architecture, Cultural Heritage

Characterization of quality of raw milk and pasteurized commercialized informally in Colorado do Oeste City, RO, Brazil | Caracterização da qualidade do leite cru e pasteurizado comercializado informalmente na cidade de Colorado do Oeste, RO, Brasil

Directory of Open Access Journals (Sweden)

Edmar Costa Alves

2016-05-01

Full Text Available Milk quality can be characterized by physicochemical parameters indicating possible changes in the product properties. The poor quality of milk may affect human health and compromise the shelf life of the product. The objective of this study was to characterize the physicochemical quality of milk and to perform reductase testing of twenty four samples of raw milk and of twelve samples of pasteurized milk being informally commercialized in the city of Colorado do Oeste, RO. The density, the cryoscopic index, the fat (using the method of Gerber, the acidity (in Dornic degrees, and the defatted solids (SNG (according to official methods were evaluated accoring to the Normative Instruction 68. The results of cryoscopy and density, showed that 27% (n = 10 and 27% (n = 10 of the samples, respectively, do not comply with the IN-62 criteria. For the content of defatted solids, 19% of the samples were at odds with the legislation. The assessment of physicochemical parameters suggest that the informal trade of milk in the studied retail outlets can compromise the integrity of the product, a problem that might be solved by correcting and intensifying enforcement actions. -------------------------------------------------------------------------------------------- A qualidade do leite pode ser caracterizada pelos parâmetros físico-químicos que indicam possíveis alterações nas propriedades do produto. A baixa qualidade do leite pode afetar a saúde humana e comprometer a vida útil do produto. O objetivo desse estudo foi caracterizar a qualidade físico-química em 24 amostras de leite cru e 12 amostras de leite pasteurizado comercializados informalmente na cidade de Colorado do Oeste, RO. Foram avaliados: densidade; índice crioscópico; gordura pelo método de Gerber; acidez em graus Dornic e sólidos desengordurados, de acordo com os métodos oficiais preconizados pela Instrução Normativa no 68. Os resultados da crioscopia e da densidade, apontam

Some Ecological Mechanisms to Generate Habitability in Planetary Subsurface Areas by Chemolithotrophic Communities: The Ro Tinto Subsurface Ecosystem as a Model System

Science.gov (United States)

Fernández-Remolar, David C.; Gómez, Felipe; Prieto-Ballesteros, Olga; Schelble, Rachel T.; Rodríguez, Nuria; Amiols, Ricardo

2008-02-01

Chemolithotrophic communities that colonize subsurface habitats have great relevance for the astrobiological exploration of our Solar System. We hypothesize that the chemical and thermal stabilization of an environment through microbial activity could make a given planetary region habitable. The MARTE project ground-truth drilling campaigns that sampled cryptic subsurface microbial communities in the basement of the Ro Tinto headwaters have shown that acidic surficial habitats are the result of the microbial oxidation of pyritic ores. The oxidation process is exothermic and releases heat under both aerobic and anaerobic conditions. These microbial communities can maintain the subsurface habitat temperature through storage heat if the subsurface temperature does not exceed their maximum growth temperature. In the acidic solutions of the Ro Tinto, ferric iron acts as an effective buffer for controlling water pH. Under anaerobic conditions, ferric iron is the oxidant used by microbes to decompose pyrite through the production of sulfate, ferrous iron, and protons. The integration between the physical and chemical processes mediated by microorganisms with those driven by the local geology and hydrology have led us to hypothesize that thermal and chemical regulation mechanisms exist in this environment and that these homeostatic mechanisms could play an essential role in creating habitable areas for other types of microorganisms. Therefore, searching for the physicochemical expression of extinct and extant homeostatic mechanisms through physical and chemical anomalies in the Mars crust (i.e., local thermal gradient or high concentration of unusual products such as ferric sulfates precipitated out from acidic solutions produced by hypothetical microbial communities) could be a first step in the search for biological traces of a putative extant or extinct Mars biosphere.

Binding of antibodies to the extractable nuclear antigens SS-A/Ro and SS-B/La is induced on the surface of human keratinocytes by ultraviolet light (UVL): Implications for the pathogenesis of photosensitive cutaneous lupus

International Nuclear Information System (INIS)

Furukawa, F.; Kashihara-Sawami, M.; Lyons, M.B.; Norris, D.A.

1990-01-01

Autoantibodies to the non-histone nucleoprotein antigens SS-A/Ro, SS-B/La, and RNP are highly associated with photosensitive cutaneous lupus erythematosus (LE). In order to better understand the potential mechanisms of ultraviolet (UV) light on photosensitivity in patients with cutaneous LE, we designed immunopathologic in vitro and in vivo experiments to evaluate the effects of UV on the binding of such autoantibodies to the surface of human keratinocytes, one major target of immunologic damage in photosensitive LE. Short-term 2% paraformaldehyde fixation of suspensions of cultured human keratinocytes previously incubated with monospecific antiserum probes enabled the detection of ENA expression on the cell surface by flow-cytometry analysis. UVB light (280-320 nm) induced the binding of monospecific antibody probes for SS-A/Ro and SS-B/La on keratinocytes in a dose-dependent pattern with maximal induction observed at the dose of 200 mJ/cm2 UVB. Binding of SS-A/Ro, SS-B/La, and RNP antibody was augmented strongly, but binding of anti-Sm was very weak. In contrast, UVA (320-400 nm) light had no effect on the induction of binding of these antibody probes. Identical results were seen by standard immunofluorescence techniques. Hydroxyurea-treated keratinocytes showed similar induction of those antigens by UVB irradiation, which suggested that ENA expression on cultured keratinocytes by UVB were cell-cycle independent. Tunicamycin, an inhibitor of glycosylation of proteins, reduced UVB light effect on the SS-A/Ro and SS-B/La antigen's expression. These in vitro FACS analyses revealed that ENA augmentation on the keratinocyte cell surface was dose dependent, UVB dependent, glycosylation dependent, and cell-cycle independent. In vivo ENA augmentation on the keratinocyte surface was examined in suction blister epidermal roofs

European Society for the History of Science - Letter from the future president

Czech Academy of Sciences Publication Activity Database

Štrbáňová, Soňa

2010-01-01

Roč. 52, č. 4 (2010), s. 361-362 ISSN 0008-8994 Institutional research plan: CEZ:AV0Z80630520; CEZ:AV0Z80770509 Keywords : history of science and technology * European Society for the History of Science Subject RIV: AB - History

Shutdown dose rate analysis of European test blanket modules shields in ITER Equatorial Port #16

Energy Technology Data Exchange (ETDEWEB)

Juárez, Rafael, E-mail: rjuarez@ind.uned.es [Departamento de Ingeniería Energética, ETSII-UNED, Calle Juan del Rosal 12, Madrid 28040 (Spain); Sauvan, Patrick; Perez, Lucia [Departamento de Ingeniería Energética, ETSII-UNED, Calle Juan del Rosal 12, Madrid 28040 (Spain); Panayotov, Dobromir; Vallory, Joelle; Zmitko, Milan; Poitevin, Yves [Fusion for Energy (F4E), Torres Diagonal Litoral B3, Josep Pla 2, Barcelona 08019 (Spain); Sanz, Javier [Departamento de Ingeniería Energética, ETSII-UNED, Calle Juan del Rosal 12, Madrid 28040 (Spain)

2016-11-01

Highlights: • Nuclear analysis for European TBMs and shields, in ITER Equatorial Port #16, has been conducted in support of the ‘Concept Design Review’ from ITER. • The objective of the work is the characterization of the Shutdown Dose Rates at Equatorial Port #16 interspace. • The role played by the TBM and TBM shields, the equatorial port gaps and the vacuum vessel permeation, in terms of neutron flux transmission is assessed. • The role played by the TBM, TBM shields, Port Plug Frame, Pipe Forest and the machine in terms of activation is also investigated. - Abstract: ‘Fusion for Energy’ (F4E) is designing, developing, and implementing the European Helium-Cooled Lead-Lithium (HCLL) and Helium-Cooled Pebble-Bed (HCPB) Test Blanket Systems (TBSs) for ITER (Nuclear Facility INB-174). An essential element of the Conceptual Design Review (CDR) of these TBSs is the demonstration of capability of Test Blanket Modules (TBM) and their shields to fulfil their function and comply with the design requirements. One of the TBM shields highly relevant design aspects is the project target for shutdown dose rates (SDDR) in the interspace. We investigated two functions of the TBMs and TBM shields—the neutron flux attenuation along the shields, and the reduction of the activation of the components contributing to SDDR. It is shown that TBMs and TBM shields reduce significantly the neutron flux in the port plug (PP). In terms of neutron flux attenuation, the TBM shield provides sufficient neutron flux reduction, being responsible for 5 × 10{sup 6} n/cm{sup 2} s at port interspace, while the EPP gaps and BSM gaps are responsible for 5 × 10{sup 7} n/cm{sup 2} s each. When considering closed upper, lower and lateral neighbour equatorial ports (thus, excluding the cross-talk between ports), a SDDR of 121 μSv/h averaged near the port closure flange was obtained, out of which, only 4 μSv/h are due to the activation of TBMs and TBM shields. Maximum SDDR in the range

Behavior of the equivalent slab thickness over three European stations

Czech Academy of Sciences Publication Activity Database

Mosert, M.; Magdaleno, S.; Burešová, Dalia; Altadill, D.; Gende, M.; Gularte, E.; Scida, L.

2013-01-01

Roč. 51, č. 4 (2013), s. 677-682 ISSN 0273-1177 Institutional support: RVO:68378289 Keywords : Ionospheric slab thickness * F2-layer peak * TEC * European stations Subject RIV: DG - Athmosphere Sciences, Meteorology Impact factor: 1.238, year: 2013 http://www.sciencedirect.com/science/article/pii/S0273117712003754

Financial market development in the Central and Eastern European countries

Czech Academy of Sciences Publication Activity Database

Berglund, T.; Hanousek, Jan; Mramor, D.

2006-01-01

Roč. 7, č. 4 (2006), s. 280-282 ISSN 1566-0141. [ Financial market development in the Central and Eastern European countries. Prague, 26.05.2006-27.05.2006] Institutional research plan: CEZ:AV0Z70850503 Keywords : financial markets * Central and Eastern Europe Subject RIV: AH - Economics

Formalized 2003 European Guidelines on Cardiovascular Disease Prevention in Clinical Practice

Czech Academy of Sciences Publication Activity Database

Peleška, Jan; Anger, Z.; Buchtela, David; Tomečková, Marie; Veselý, Arnošt

2004-01-01

Roč. 25, - (2004), s. 444 ISSN 0195-668X. [ESC Congress 2004. 28.08.2004-01.09.2004, Munich] Institutional research plan: CEZ:AV0Z1030915 Keywords : formalized European guidelines on CVD prevention * computer GLIF model * decision algorithm Subject RIV: BD - Theory of Information

Theoretical resonant electron-impact vibrational excitation, dissociative recombination and dissociative excitation cross sections of ro-vibrationally excited BeH"+ ion

International Nuclear Information System (INIS)

Laporta, V.; Chakrabarti, K.; Celiberto, R.; Janev, R. K.; Mezei, J. Zs.; Niyonzima, S.; Tennyson, J.; Schneider, I.F.

2017-01-01

A theoretical study of resonant vibrational excitation, dissociative recombination and dissociative excitation processes of the beryllium monohydride cation, BeH"+ , induced by electron impact, is reported. Full sets of ro-vibrationally-resolved cross sections and of the corresponding Maxwellian rate coefficients are presented for the three processes. Particular emphasis is given to the high-energy behaviour. Potential curves of "2σ"+, "2σ and "2δ symmetries and the corresponding resonance widths, obtained from R-matrix calculations, provide the input for calculations which use a local complex-potential model for resonant collisions in each of the three symmetries. Rotational motion of nuclei and isotopic effects are also discussed. The relevant results are compared with those obtained using a multichannel quantum defect theory method. Full results are available from the Phys4Entry database.

New thematic publication of the European Physical Society

Czech Academy of Sciences Publication Activity Database

Macková, Anna

2017-01-01

Roč. 62, č. 2 (2017), s. 74-76 ISSN 0032-2423 R&D Projects: GA MŠk LM2015056 Institutional support: RVO:61389005 Keywords : cultural heritage * European Physical Society Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders OBOR OECD: Nuclear physics http://www.edp-open.org/ images/stories/books/fulldl/Nuclear -physics-for-cultural-heritage.pdf

COMPETITION BETWEEN CONTAINER PORTS IN THE NORTHERN ADRIATIC

OpenAIRE

Elen Twrdy; Milan Batista

2014-01-01

World trade has changed in the last decade such that container traffic flows are oriented towards more parts of the European continent. The European container port system is not a homogeneous set of ports; instead it consists of several big ports (e.g., Rotterdam, Hamburg, Algeciras...) and a large number of medium and small ports. Northern Adriatic (NA) ports, namely Rijeka, Koper, Trieste, Venice and Ravenna, are small ports. Each of these ports have different development plans but in varyi...

Environmental risk assessment of water quality in harbor areas: a new methodology applied to European ports.

Science.gov (United States)

Gómez, Aina G; Ondiviela, Bárbara; Puente, Araceli; Juanes, José A

2015-05-15

This work presents a standard and unified procedure for assessment of environmental risks at the contaminant source level in port aquatic systems. Using this method, port managers and local authorities will be able to hierarchically classify environmental hazards and proceed with the most suitable management actions. This procedure combines rigorously selected parameters and indicators to estimate the environmental risk of each contaminant source based on its probability, consequences and vulnerability. The spatio-temporal variability of multiple stressors (agents) and receptors (endpoints) is taken into account to provide accurate estimations for application of precisely defined measures. The developed methodology is tested on a wide range of different scenarios via application in six European ports. The validation process confirms its usefulness, versatility and adaptability as a management tool for port water quality in Europe and worldwide. Copyright © 2015 Elsevier Ltd. All rights reserved.

Mezinárodní vědecké konference v Bělehradu a Sarajevu ke 100. výročí vzniku první světové války

Czech Academy of Sciences Publication Activity Database

Hladký, Ladislav

2014-01-01

Roč. 100, č. 2 (2014), s. 439-451 ISSN 0037-6922 Institutional support: RVO:67985963 Keywords : First World War * history * the hundredth anniversary of the beginning of the First World War in 1914 * international science conferences * Belgrade * Sarajevo * Czech-South Slavic relations Subject RIV: AB - History

Foreign news and spillovers in emerging European stock markets

Czech Academy of Sciences Publication Activity Database

Hanousek, Jan; Kočenda, E.

2011-01-01

Roč. 19, č. 1 (2011), s. 170-188 ISSN 0965-7576 R&D Projects: GA ČR(CZ) GAP403/11/0020; GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : emerging European stock market s * foreign news * intraday data Subject RIV: AH - Economics Impact factor: 0.631, year: 2011

Structural changes in Central and Eastern European economies: breaking news or breaking the ice?

Czech Academy of Sciences Publication Activity Database

Égert, B.; Jiménez-Rodríguez, R.; Kočenda, Evžen; Morales-Zumaquero, A.

2006-01-01

Roč. 39, 1-2 (2006), s. 85-103 ISSN 1573-9414 R&D Projects: GA MŠk LC542 Institutional research plan: CEZ:MSM0021620846 Keywords : Central and Eastern European (CEE) countries * multiple structural breaks * volatility Subject RIV: AH - Economics

Integrated removal of inorganic contaminants from acid mine drainage using BOF slag, lime, soda ash and reverse osmosis (RO): Implication for the production of drinking water

CSIR Research Space (South Africa)

Masindi, Vhahangwele

2017-06-01

Full Text Available softeners will pro- duce water of drinking standard. Acknowledgements The authors wish to express their sincere gratitude to the Council for Scientific and Industrial research (CSIR), Tshwane University of Technology for providing lab space to execute... quality. As such, this study proved that the coupling of RO process to BOF slag and different softeners will produce water of drinking standard. Acknowledgements The authors wish to express their sincere gratitude to the Council for Scientific...

Sources and methods to reconstruct past masting patterns in European oak species

Czech Academy of Sciences Publication Activity Database

Szabó, Péter

2012-01-01

Roč. 34, č. 4 (2012), s. 203-214 ISSN 0307-1375 R&D Projects: GA AV ČR IAA600050812 Grant - others:ERC - European Union(XE) FP7/2007-2013 ERC no. 278065 Institutional support: RVO:67985939 Keywords : mast * oak * historical ecology Subject RIV: EF - Botanics

The effect of the antipsoriatic drug metabolite etretin (Ro 10-1670) on UVB irradiation induced changes in the metabolism of arachidonic acid in human keratinocytes in culture

International Nuclear Information System (INIS)

Punnonen, Kari; Jansen, C.T.; Puustinen, Tapio

1986-01-01

[ 14 C]Arachidonic acid was avidly incorporated into human keratinocytes in culture and following exposure to UVB irradiation of 9 mJ/cm 2 (erythemally effective, EE) substantial amounts of 14 C-radiolabel were released from the cells. The release of radiolabel was accompanied by a decrease in the labelling of phosphatidylethanolamine whereas the labelling of triacylglycerols and cholesteryl esters was increased. Keratinocytes produced significant amounts of prostaglandin E 2 (PGE 2 ) and following UVB irradiation of 9 mJ/cm 2 (EE) the formation of prostaglandin E 2 was increased. Etretin (Ro 10-1670), the active metabolite of the antipsoriatic drug etretinate (Ro 10-9359), affected significantly neither the total release of radiolabel induced by UVB nor the formation of prostaglandin E 2 . However, in the presence of etretin the UVB irradiation induced transfer of [ 14 C]arachidonic acid into triacylglycerols and cholesteryl esters was not increased as much as in the corresponding experiments without etretin. On the basis of the present study it appears that etretin dose not interfere with the release of arachidonic acid in amounts which could be related to the therapeutic effects of the combination of retinoids with UVB irradiation (Re-UVB) in the treatment of psoriasis. (author)

An evaluation of the impact of the European Association of Social Psychology: A response to Schruijer (2012)

Czech Academy of Sciences Publication Activity Database

Hewstone, M.; Liebkind, K.; Lewicka, M.; Laszlo, J.; Voci, A.; Contarello, A.; Gomez, A.; Hantzi, A.; Bilewicz, M.; Guinote, A.; Graf, Sylvie; Petkova, K.

2012-01-01

Roč. 25, č. 3 (2012), s. 117-126 ISSN 0952-6951 Institutional support: RVO:68081740 Keywords : social psychology * science * European Association of Social Psychology Subject RIV: AN - Psychology Impact factor: 0.442, year: 2012

Safety analysis of coupling system of hybrid (MED-RO) nuclear desalination system utilising waste heat from HTGR

International Nuclear Information System (INIS)

Raha, Abhijit; Kishore, G.; Rao, I.S.; Adak, A.K.; Srivastava, V.K.; Prabhakar, S.; Tewari, P.K.

2010-01-01

To meet the generation IV goals, High Temperature Gas Cooled Reactors (HTGRs) are designed to have relatively higher thermal efficiency and enhanced safety and environmental characteristics. It can provide energy for combined production of hydrogen, electricity and other industrial applications. The waste heat available in the HTGR power cycle can also be utilized for the desalination of seawater for producing potable water. Desalination is an energy intensive process, so use of waste heat from HTGR certainly makes desalination process more affordable to create fresh water resources. So design of the coupling system, as per the safety design requirement of nuclear desalination plant, of desalination plant with HTGR is very crucial. In the first part of this paper, design of the coupling system between hybrid Multi Effect Desalination-Reverse Osmosis (MED-RO) nuclear desalination plant and HTGR to utilize the waste heat in HTGR are discussed. In the next part deterministic safety analysis of the designed coupling system of are presented in detail. It was found that all the coupling system meets the acceptance criteria for all the Postulated Initiating Events (PIE's) limited to DBA. (author)

1,5-(H, RO, RS) shift/6π-electrocyclic ring closure tandem processes on N-[(α-heterosubstituted)-2-tolyl]ketenimines: a case study of relative migratory aptitudes and activating effects.

Science.gov (United States)

Alajarín, Mateo; Bonillo, Baltasar; Orenes, Raúl-Angel; Ortín, María-Mar; Vidal, Angel

2012-12-28

A number of N-aryl ketenimines, substituted at the ortho position either with different non-cyclic acetalic functions (acetals, monothioacetals, dithioacetals) or with only one alkoxymethyl or (alkylthio)methyl group, have been prepared and submitted to thermal treatment in toluene solution. Under smooth heating the ketenimines bearing non-cyclic acetals converted into 3,4-dihydroquinolines following two competitive tandem sequences that involve the alternative 1,5 migration of a hydride or alkoxy group as the first mechanistic step, followed by subsequent 6π electrocyclic ring closure. The heterocumulenes bearing acyclic monothioacetal and dithioacetal functions converted via a unique consecutive process involving the selective migration of the alkanethiolate group. Ketenimines bearing only one ether or thioether group transformed exclusively by the tandem sequence initiated by a 1,5 hydride shift. All these transformations provided as final reaction products a variety of quinoline derivatives with a range of substitution patterns. From these experiments the following order of propensity to migration can be extracted: RS > RO > H. It was also possible to estimate the following order of relative activating activities: RO > RS > H.

Multivariate study of trace element distribution in the geological record of Roñanzas Peat Bog (Asturias, N. Spain). Paleoenvironmental evolution and human activities over the last 8000 calyr BP.

Science.gov (United States)

Gallego, José Luis R; Ortiz, José E; Sierra, Carlos; Torres, Trinidad; Llamas, J F

2013-06-01

Trace element concentrations in the Roñanzas peat bog record reveal a contribution of natural processes but the influence of anthropogenic factors predominates in the last two millenniums, particularly aerosol deposition linked to mining and industrial activities in northern Spain. We observed that the Roñanzas record can be considered a preserved environment, suitable to search for local (major elements. Our study design represents a novel approach to assign natural vs. human contributions in peatlands. Therefore, synergies obtained by the simultaneous study of multivariate statistics and enrichment factors allow robust conclusions about paleoenvironmental evolution and human activities. Anthropogenic influence has also been reported in similar records in other parts of Europe, thereby suggesting large-scale sources for atmospheric pollution. However, here we revealed remarkable particularities, such as the association of Cd, Zn and Pb, mainly linked to regional and local factors (mining and more recently the metallurgical industry), whereas we propose that the occurrence of Hg is associated with a combination of regional factors and global atmospheric pollution. Copyright © 2013 Elsevier B.V. All rights reserved.

Estudos de biodegradação de óleo diesel por consórcio microbiano coletado em Porto Velho - RO, amazônia

Directory of Open Access Journals (Sweden)

Cleber C. Luz

2011-01-01

Full Text Available The goal of this research was to evaluate the biodegradation of diesel by a microbial consortium collected in a region close to distributors of fuel. The experiments were monitored by SPME-GC-FID and SPME-GC-MS. The consortium showed a high potential for production of biosurfactants, presenting an emulsification index of 53%. The consortium degraded completely n-alkanes, while dimethylnaphtalene, hepthyl-cyclohexane and 2,6,10-trimethyl-undecane were partially degraded and pristane was not degraded. From this consortium five strains were isolated and identified as Acinetobacter baumannii. Based on this initial investigation this consortium appears to be effective for bioremediation in Porto Velho - RO region.

Modeling of RO/NF membrane rejections of PhACs and organic compounds: a statistical analysis

Directory of Open Access Journals (Sweden)

G. Amy

2008-07-01

Full Text Available Rejections of pharmaceutical compounds (Ibuprofen, Diclofenac, Clofibric acid, Naproxen, Primidone, Phenacetin and organic compounds (Dichloroacetic acid, Trichloroacetic acid, Chloroform, Bromoform, Trichloroethene, Perchloroethene, Carbontetrachloride, Carbontetrabromide by NF (Filmtec, Saehan and RO (Filmtec, Saehan, Toray, Koch membranes were studied. Chloroform presented the lowest rejection due to small molar volume, equivalent width and length. Diclofenac and Primidone showed high rejections related to high molar volume and length. Dichloroacetic acid and Trichloroacetic acid presented good rejections caused by charge exclusion instead of steric hindrance mechanism influencing rejection. Bromoform and Trichloroethene showed low rejections due to small length and equivalent width. Carbontetrabromide, Perchloroethene and Carbontetrachloride with higher equivalent width than BF and TCE presented better rejections. A qualitative analysis of variables using Principal Component Analysis was successfully implemented for reduction of physical-chemical compound properties that influence membrane rejection of PhACs and organic compounds. Properties such as dipole moment, molar volume, hydrophobicity/hydrophilicity, molecular length and equivalent width were found to be important descriptors for simulation of membrane rejection. For membranes used in the experiments, we may conclude that charge repulsion was an important mechanism of rejection for ionic compounds. After analysis with Multiple Linear Regression, we also may conclude that membrane rejection of neutral compounds was well predicted by molar volume, length, equivalent width, hydrophobicity/hydrophilicity and dipole moment. Molecular weight was a poor descriptor variable for rejection modelling. We were able to provide acceptable statistical significance for important results.

Charged, but Found "Not Guilty": Innocence of the Suspect Bridging Ligands [RO(O)CNNC(O)OR](2-) = L2- in [(acac)(2)Ru(mu-L)Ru(acac)(2)](n), n = +,0,-,2-

Czech Academy of Sciences Publication Activity Database

Roy, S.; Sarkar, B.; Imrich, H.-G.; Fiedler, Jan; Záliš, Stanislav; Jimenez-Aparicio, R.; Urbanos, F. A.; Mobin, S. M.; Lahiri, G. K.; Kaim, W.

2012-01-01

Roč. 51, č. 17 (2012), s. 9273-9281 ISSN 0020-1669 R&D Projects: GA MŠk LD11086 Institutional support: RVO:61388955 Keywords : DINUCLEAR RUTHENIUM COMPLEXES * MOLECULAR-ORBITAL METHODS * ANION-RADICAL COMPLEXES Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 4.593, year: 2012

Abundance of Cottus poecilopus is influenced by O2 saturation, food density and Salmo trutta in three tributaries of the Rožnovská Bečva River, Czech Republic

Czech Academy of Sciences Publication Activity Database

Baran, Roman; Kubečka, Jan; Kubín, M.; Lojkásek, B.; Mrkvička, T.; Ricard, Daniel; Rulík, M.

2015-01-01

Roč. 86, č. 2 (2015), s. 805-811 ISSN 0022-1112. [Česká ichtyologická konference /13./. Červená nad Vltavou, 24.10.2012-26.10.2012] Institutional support: RVO:60077344 Keywords : alpine bullhead * brown trout * macroinvertebrates * organic carbon * shading * water temperature Subject RIV: EH - Ecology, Behaviour Impact factor: 1.246, year: 2015

Vliv skladovací teploty a ročníku na barvu smažených bramborových lupínků transgenních linií odrůdy Vladan

Czech Academy of Sciences Publication Activity Database

Vacek, J.; Buchler, P.; Navrátil, Oldřich

2012-01-01

Roč. 60, č. 9 (2012), s. 194-199 ISSN 0139-6013 R&D Projects: GA MŠk 1M06030 Institutional research plan: CEZ:AV0Z50380511 Keywords : transgenic potato * reducing sugars * chips/crisps colour Subject RIV: EB - Genetics ; Molecular Biology

Experimental demonstration of a real-time PAM-4 Q-band RoF system based on CMMA equalization and interleaved RS code

Science.gov (United States)

Deng, Rui; Yu, Jianjun; He, Jing; Wei, Yiran

2018-05-01

In this paper, we experimentally demonstrated a complete real-time 4-level pulse amplitude modulation (PAM-4) Q-band radio-over-fiber (RoF) system with optical heterodyning and envelope detector (ED) down-conversion. Meanwhile, a cost-efficient real-time implementation scheme of cascaded multi-modulus algorithm (CMMA) equalization is proposed in this paper. By using the proposed scheme, the CMMA equalization is applied in the system for signal recovery. In addition, to improve the transmission performance of the system, an interleaved Reed-Solomon (RS) code is applied in the real-time system. Although there is serious power impulse noise in the system, the system can still achieve a bit error rate (BER) at below 1 × 10-7 after 25 km standard single mode fiber (SSMF) transmission and 1-m wireless transmission.

Observations of Equatorial Kelvin Wave Modes in FORMOSAT-3/COSMIC GPS RO Temperature Profiles

Directory of Open Access Journals (Sweden)

Potula Sree Brahmanandam

2010-01-01

Full Text Available In this study, we analyze FORMOSAT-3/COSMIC (F3/C GPS radio occultation (RO derived temperature components for the period September 2006 to February 2008. Results show the presence of slow Kelvin waves (wave period > 10 days with higher zonal wavenumbers (either one or two in the upper troposphere and lower stratosphere (UTLS. The vertical wavelengths of these waves are found to be in the range of 5 - 12 km. The predominant Kelvin waves observed in the temperature fluctuations are in the altitude range between 15 and 28 km and centered on the tropical tropopause. The downward phase progression of these waves suggests that the derived waves are propagating upward, with the source region located at lower altitudes possibly due to tropical convective heating. The zonal winds retrieved using radiosonde observations over Singapore (1¢XN, 104¢XE during this period show a periodicity of ~24 - 26 months in the stratosphere, and quasi-biennial oscillation (QBO characteristics with eastward zonal winds from March 2006 to May 2007 and westward winds from June 2007 to July 2008 respectively. Our results further show that the Kelvin wave characteristics are enhanced during the westward phase of QBO and diminish during the eastward phase, in line with the previous reported results. Furthermore, an examination of outgoing longwave radiation (OLR data shows that deep convection activity is developed episodically over the Indonesian archipelago during the observation period, thereby indicating that the Kelvin wave events observed in temperature fluctuations are either driven by convective activity (convectively coupled waves or by a broad spectrum of convective variability (free waves over the Indonesian region.

IFPE/EFE-RO, Experimental Fuel Elements RO89 and RO51 in TRIGA 14 MW Reactor (INR-Pitesti)

International Nuclear Information System (INIS)

Paraschiv, Marius; Turnbull, J.A.

2002-01-01

Description of program or function: Romanian irradiation tests concerned with Candu type fuel elements behavior and with the limits of the design parameters. A particular feature of the Candu fuel project is the small plenum (void volume) added for relaxation of the fission gases, which are inherently released during the fuel irradiation. Two irradiation tests in the C2 device from the TRIGA 14 MW reactor were performed between the years 1985-1987. The tests were done to evaluate the effect of the fuel density on the time-evolution of the fission gas pressure. Experimental fuel elements were adequately instrumented with pressure transducers to follow the fission gas pressure changes during fuel irradiation. The first irradiation test was conducted on the fuel element coded No.89 whose main characteristics were the nominal values of the main fuel design parameters. The second one was conducted on the fuel element coded No.51. Because of the axial flux asymmetry inside the TRIGA reactor core, the experimental elements are shorter in length than the Candu fuel design. The irradiation tests consisted in evaluation of the time-evolution of the internal pressure from two experimental fuel elements having the main design characteristics as the Romanian Candu type fuel element design and to follow the dependence of the internal pressure of the fission gas on the fuel density

Neuroprotekcyjne właściwości związków pochodzenia roślinnego: triterpeny pentacykliczne

Directory of Open Access Journals (Sweden)

Monika Orłowska-Majdak

2014-12-01

Full Text Available Ludzki mózg to struktura wykazująca ogromną zmienność w ciągu życia osobniczego. W pierwszym okresie zmiany budowy i czynności spowodowane są procesami rozwoju i dojrzewania. Następnie, dzięki niezwykłej plastyczności synaptycznej, poszczególne ośrodki mózgu przystosowują się do wymagań środowiska, w jakim człowiek funkcjonuje, i do stylu jego życia. Po 40. roku życia włącza się proces zaprogramowanej śmierci neuronów, czyli apoptozy, a w stanie choroby neurony mogą ginąć w procesie nekrozy lub aponekrozy. Neurogeneza na bazie miejscowych albo transplantowanych komórek macierzystych mózgu pełni funkcję naprawczą w powstałych uszkodzeniach, ale może także mieć związek z chorobami psychicznymi i neurologicznymi. U podstaw neuroprotekcji leżą procesy antyoksydacyjne, przeciwzapalne, antyapoptotyczne i przeciwdziałające destrukcyjnemu działaniu jonów wapnia. Wspierającą funkcję w działaniu neuroprotekcyjnym mogą mieć związki pochodzenia roślinnego, podawane w ramach fitoterapii. W ostatnich latach zwrócono uwagę na neuroprotekcyjne właściwości pentacyklicznych triterpenów i ich pochodnych. W pracy omówiono właściwości neuroprotekcyjne kwasu ursolowego, oleanolowego, maslinowego, asjatowego, betulinowego, bosweliowego oraz saponin triterpenowych pozyskiwanych z roślin Bupleurum i Panax ginseng. Saponiny ginseng dodatkowo nasilają neurogenezę w mózgu. Sugeruje się potencjał stosowania wymienionych związków w terapii wielu chorób neurologicznych i psychicznych – z kilkoma zastrzeżeniami: 1 kierunek działania może zależeć od dawki; 2 związki te mogą różnie działać na neurony różnych rodzajów; 3 mogą istnieć niekorzystne interakcje z innymi lekami stosowanymi równocześnie. Większość doświadczeń z użyciem triterpenów wykonano na zwierzętach bądź w hodowlach komórkowych, zagadnienie wymaga więc dalszych badań na ludziach.

Structural analysis within the Rožná and Olší uranium deposits (Strážek Moldanubicum) for the estimation of deformation and stress conditions of underground gas storage

Czech Academy of Sciences Publication Activity Database

Ptáček, Jiří; Melichar, R.; Hájek, Antonín; Koníček, Petr; Souček, Kamil; Staš, Lubomír; Kříž, P.; Lazárek, J.

2013-01-01

Roč. 10, č. 2 (2013), s. 237-246 ISSN 1214-9705 Institutional support: RVO:68145535 Keywords : structural analysis * deformation * stress * underground gas storage Subject RIV: DH - Mining, incl. Coal Mining Impact factor: 0.667, year: 2013 http://www.irsm.cas.cz/materialy/acta_content/2013_02/acta_170_13_Ptacek_237-246.pdf

Sexuality: zpráva z 2. ročníku vědecké konference s mezinárodní účastí konané v Nitře

Czech Academy of Sciences Publication Activity Database

Sloboda, Zdeněk

2008-01-01

Roč. 9, č. 2 (2008), s. 85-87 ISSN 1213-0028. [ Sexuality 2008. Nitra, 20.09.2007-21.09.2007] R&D Projects: GA AV ČR 1QS700280503; GA AV ČR IAA700280804 Institutional research plan: CEZ:AV0Z70280505 Keywords : sexualities * sexuality * conference Subject RIV: AO - Sociology, Demography

Drivers of treeline shift in different European mountains

Czech Academy of Sciences Publication Activity Database

Cudlín, Pavel; Klopčič, M.; Tognetti, R.; Máliš, F.; Alados, C. L.; Bebi, P.; Grunewald, K.; Zhiyanski, M.; Andonowski, V.; La Porta, N.; Bratanova-Doncheva, S.; Kachaunová, E.; Edwards-Jonášová, Magda; Ninot, J. M.; Rigling, A.; Hofgaard, A.; Hlásný, T.; Skalák, Petr; Wielgolaski, F. E.

2017-01-01

Roč. 73, 1-2 (2017), s. 135-150 ISSN 0936-577X R&D Projects: GA MŠk(CZ) LO1415; GA MŠk(CZ) LD14039 Institutional support: RVO:67179843 Keywords : Vegetation zone shift * Climate change * Climate models * Treeline ecotone * European mountains * Ecosystem services Subject RIV: EH - Ecology, Behaviour OBOR OECD: Environmental sciences (social aspects to be 5.7) Impact factor: 1.578, year: 2016

Towards the European(-ised) public sphere: the case of EP elections in the Czech Republic and Slovakia

Czech Academy of Sciences Publication Activity Database

Kovář, J.; Kovář, Kamil

2013-01-01

Roč. 9, č. 5 (2013), s. 696-722 ISSN 1815-347X Institutional support: PRVOUK-P23 Keywords : Europeanisation * European Parliament elections * media Subject RIV: AH - Economics http://www.jcer.net/index.php/jcer/article/download/575/440

Shipping emissions in ports

OpenAIRE

Merk, Olaf

2014-01-01

Shipping emissions in ports are substantial, accounting for 18 million tonnes of CO2 emissions, 0.4 million tonnes of NOx, 0.2 million of SOx and 0.03 million tonnes of PM10 in 2011. Around 85% of emissions come from containerships and tankers. Containerships have short port stays, but high emissions during these stays. Most of CO2 emissions in ports from shipping are in Asia and Europe (58%), but this share is low compared to their share of port calls (70%). European ports have much less emi...

Podnikové komunikační a informační webové portály

OpenAIRE

Hrbatová, Gabriela

2012-01-01

Tato diplomová práce se zabývá analýzou a definicí požadavků pro implementaci vhodného komunikačního a informačního webového portálu pro podnik OR-NEXT spol. s r.o., který se zaměřuje na implementace informačních systémů QI a Lawson M3, systémovou integraci obecně a poskytování poimplementačních služeb. Portál zdokonalí komunikaci se zákazníky a zjednoduší a zrychlí podnikové procesy týkající se správy zákaznického portfolia a zákaznických požadavků. This diploma‘s thesis deals with the an...

Benchmark dynamics in the environmental performance of ports.

Science.gov (United States)

Puig, Martí; Michail, Antonis; Wooldridge, Chris; Darbra, Rosa Mari

2017-08-15

This paper analyses the 2016 environmental benchmark performance of the port sector, based on a wide representation of EcoPorts members. This is the fifth time that this study has been conducted as an initiative of the European Sea Ports Organisation (ESPO). The data and results are derived from the Self-Diagnosis Method (SDM), a concise checklist against which port managers can self-assess the environmental management of their port in relation to the performance of the EcoPorts membership. The SDM tool was developed in the framework of the ECOPORTS project (2002-2005) and it is managed by ESPO. A total number of 91 ports from 20 different European Maritime States contributed to this evaluation. The main results are that air quality remains as the top environmental priority of the respondent ports, followed by energy consumption and noise. In terms of environmental management, the study confirms that key components are commonly implemented in the majority of European ports. 94% of contributing ports have a designated environmental manager, 92% own an environmental policy and 82% implement an environmental monitoring program. Waste is identified as the most monitored issue in ports (80%), followed by energy consumption (73%) and water quality (70%). Copyright © 2017 Elsevier Ltd. All rights reserved.

Distribution and tumour cytotoxicity of the radiosensitizer misonidazole (Ro-07-0582) in C57 mice

International Nuclear Information System (INIS)

Pedersen, J.E.; Smith, M.R.; Bugden, R.D.; Peckham, M.J.

1979-01-01

The distribution and clearance of misonidazole (MIS=Ro-07-0582) were studied in C57 mouse tissued and in transplants of Lewis lung tumour. The half life of the drug in blood after a dose of 1mg/g i.p. was 3 h. Some tissues, such as liver, were found to have consistently low MIS levels, and this was found to be due to degradation of the drug after removal of the tissues from the host. The in vivo cytotoxicity of MIS to Lewis lung tumour cells was studied using an in-vitro colony assay. After half of the tumours had been irradiated with 10 Gy to kill most of the oxic cells, the mice received i.p. injections of MIS. To simulate the longer drug exposure of human tumour cells (due to the longer half life in man) a repeated injection regime was used in some mice. There was no significant cell kill after a single dose, but with a prolonged exposure to the drug in the multiply injected animals, cell survival was reduced to 50% of control in both the irradiated and unirradiated tumours. Since the hypoxic fraction of the unirradiated tumour is probably not more than 30%, it would appear that MIS is not selectively cytotoxic to hypoxic cells. However, MIS had a much greater cytotoxic effect upon hypoxic Lewis lung tumour cells in vitro, with very little or no effect on cells grown in air. This would support the theory that the presence of hypoxic cells is essential for the expression of MIS cytotoxicity. (author)

Wavelet Analysis of Central European Stock Market Behaviour During the Crisis

Czech Academy of Sciences Publication Activity Database

Baruník, Jozef; Vácha, Lukáš

2009-01-01

Roč. 2009, č. 23 (2009), s. 1-14 R&D Projects: GA ČR GP402/08/P207; GA ČR GD402/09/H045 Grant - others:GAUK(CZ) 46108 Institutional research plan: CEZ:AV0Z10750506 Keywords : wavelet analysis * multiresolution analysis * Central European stock markets * financial crisis Subject RIV: AH - Economics

Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease

DEFF Research Database (Denmark)

Brauner, S; Zhou, W; Backlin, C

2015-01-01

OBJECTIVE: TRIM21 (also known as Ro52) is an autoantigen in rheumatic disease and is predominantly expressed in leucocytes. Overexpression is associated with decreased proliferation, and the TRIM21 gene maps to a tumour suppressor locus. We therefore investigated the expression of TRIM21...... in patients with diffuse large B-cell lymphoma (DLBCL) and its potential usefulness as a prognostic biomarker. MATERIALS AND METHODS: TRIM21 expression levels were assessed by immunohistochemistry in lymphoma biopsies from three cohorts of patients with DLBCL: 42 patients with rheumatic disease treated...... with a cyclophosphamide, vincristine, doxorubicin and prednisone (CHOP)-like regimen, 76 CHOP-treated and 196 rituximab-CHOP-treated nonrheumatic patients. Expression was correlated with clinical and biomedical parameters. TRIM21 expression was assessed in relation to lymphocyte proliferation by quantitative PCR...

A comment on "Ab initio study: the potential energy curves and ro-vibrational spectrum of low-lying excited states of HCl+ cation"

Science.gov (United States)

Liu, Ya-Jun; Cheng, Xin-Lu; Chen, Hua-Jun; Cheng, Jun-Xia; Song, Xiao-Shu

2018-02-01

Since the 2Π state in HCl+ is an inverted doublet, the energy of the 2Π1/2 state is higher than the 2Π3/2. Therefore, the larger value of intensity correspond to the transition of 2Π3/2. We calculated the Einstein A coefficients and radiation lifetimes for the A2Σ+-X2Π transition. Our results are in good agreement with the experimental data and theoretical values. Then the ro-vibrational line intensities of the 1-0 band were calculated for the 2Π3/2 and 2Π1/2 states of HCl+. Employing the RKR potential, the predicted band origins for Δν=1-0 are 2569.3 and 2568.55 cm-1 for 2Π3/2 and 2Π1/2, respectively.

Number Concentrations and Modal Structure of Indoor/Outdoor Fine Particles in Four European Cities.

Czech Academy of Sciences Publication Activity Database

Lazaridis, M.; Eleftheriadis, K.; Ždímal, Vladimír; Schwarz, Jaroslav; Wagner, Zdeněk; Ondráček, Jakub; Drossinos, Y.; Glytsos, T.; Vratolis, S.; Torseth, K.; Moravec, Pavel; Hussein, T.; Smolík, Jiří

2017-01-01

Roč. 17, č. 1 (2017), s. 131-146 ISSN 1680-8584 EU Projects: European Commission(XE) 315760 - HEXACOMM Institutional support: RVO:67985858 Keywords : indoor/outdoor aerosol * I/O ratio * modal structure Subject RIV: DG - Athmosphere Sciences, Meteorology OBOR OECD: Meteorology and atmospheric sciences Impact factor: 2.606, year: 2016

Jane Air: The Heroine as Caged Bird in Charlotte Brontë’s Jane Eyre and Alfred Hitchcock’s Rebecca L’héroïne, oiseau en cage dans Jane Eyre de Charlotte Brontë et Rebecca d’Alfred Hitchcock

Directory of Open Access Journals (Sweden)

Paul Marchbanks

2009-12-01

Full Text Available Dans le quatrième chapitre de son ouvrage intitulé Brontë Transformations (1996, Patsy Stoneman révèle l’importance des reprises et transformations dont a fait l’objet Jane Eyre (1847 de Charlotte Brontë dans diverses pièces de théâtre, romans et films depuis sa publication initiale. L’un des avatars les plus intéressants mentionné par P. Stoneman est Rebecca d’Alfred Hitchcock (1940 d’après le roman à succès éponyme de Daphné Du Maurier paru en 1938. Parmi les nombreux éléments communs au roman de Brontë et au film d’Hitchcock figurent l’héroïne orpheline consciente de son physique ordinaire, un personnage masculin maussade doté d’une épouse “présente-absente” et une intendante dont le tempérament influence l’atmosphère du manoir dans lequel l’héroïne réside temporairement. Un autre point commun, plus difficile à déceler car profondément intégré à chaque œuvre, est le portrait de l’héroïne en oiseau prisonnier. Ce(tte subtile trope/métaphore mérite d’être remarqué(e car non seulement l’image constitue un lien entre les deux œuvres mais elle permet aussi, dans ses diverses manifestations, de les différencier. Tandis que dans Jane Eyre, l’image de l’oiseau apparaît chaque fois que Jane s’échappe d’un lieu qui l’emprisonne, celle de la cage s’avère être l’élément dominant dans le film d’Hitchcock, imposant finalement des limites infranchissables à la liberté de l’héroïne.

A role for CD4+ but not CD8+ T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-3128-terminated infections

International Nuclear Information System (INIS)

Vignali, D.A.A.; Bickle, Q.D.; Taylor, M.G.; Crocker, P.; Cobbold, S.; Waldmann, H

1989-01-01

The role of CD4 + (L3/T4 + ) and CD8 + (Lyt-2 + ) T cells in immunity to Schistosoma mansoni induced by 20 krad-irradiated and Ro 11-terminated infections in mice was investigated directly by in vivo depletion of these subsets with cytotoxic rat monoclonal antibodies (mAb). Effective physical depletion was demonstrated by flow cytometric analysis and immunohistochemical staining. Functional depletion of helper activity following anti-CD4 treatment was indicated by an abrogation of concanavalin A(Con A)-induced colony-stimulating factor (CSF) release, while anti-CD8 treatment had no effect in these assays. Pre-existing S. mansoni-specific antibody levels were unaffected by anti-CD4 and anti-CD8 treatment. In vivo depletion of CD4 + T cells resulted in a dramatic reduction in immunity induced by one (up to 100%) and two (up to 70%) vaccinations with 20 krad-irradiated cercariae and also of resistance induced by Ro 11-attenuated infections (up to 100%). Depletion of CD8 + T cells had no effect on resistance induced by any of the vaccination protocols investigated. A correlation was observed between resistance and T cell-induced, macrophage-mediated killing of schistosomula in vitro, both of which were abrogated following anti-CD4 treatment but were unaffected by CD8 + T-cell depletion. The possible role of CD4 + T cells in vivo and the implications for vaccine development are discussed. (author)

Regulation of solid waste management at Brazilian ports: Analysis and proposals for Brazil in light of the European experience

International Nuclear Information System (INIS)

Jaccoud, Cristiane; Magrini, Alessandra

2014-01-01

Highlights: • Analysis of the regulatory framework relating to solid waste management in Brazilian ports. • Comparison between European best practices and Brazilian structure. • Initiatives are suggested in order to improve Brazilian ports solid waste management regulation. - Abstract: With a coastline of 8500 km, Brazil has 34 public ports and various private terminals, which together in 2012 handled 809 million tonnes of goods. The solid wastes produced (from port activities, ships and cargoes) pose a highly relevant problem, both due to the quantity and diversity, requiring a complex and integrated set of practices resulting from legal requirements and proactive initiatives. The main Brazilian law on solid waste management is recent (Law 12,305/2010) and the specific rules on solid waste in ports are badly in need of revision to meet the challenges caused by expansion of the sector and to harmonize them with the best global practices. This paper analyzes the current legal/regulatory framework for solid waste management at Brazilian ports and compares this structure with the practice in Europe. At the end, we suggest initiatives to improve the regulation of solid wastes at Brazilian ports

Changes in Inflation Dynamics under Inflation Targeting? Evidence from Central European Countries

Czech Academy of Sciences Publication Activity Database

Baxa, Jaromír; Plašil, M.; Vašíček, B.

2015-01-01

Roč. 44, č. 1 (2015), s. 116-130 ISSN 0264-9993 R&D Projects: GA ČR(CZ) GBP402/12/G097 Institutional support: RVO:67985556 Keywords : Bayesian model averaging * Central European countries * Inflation Dynamics Subject RIV: AH - Economics Impact factor: 0.997, year: 2015 http://library.utia.cas.cz/separaty/2015/E/baxa-0449816.pdf

Sperm depletion as a consequence of increased sperm competition risk in the European bitterling, Rhodeus amarus

Czech Academy of Sciences Publication Activity Database

Smith, C.; Pateman-Jones, C.; Zieba, G.; Przybylski, M.; Reichard, Martin

2009-01-01

Roč. 77, č. 5 (2009), s. 1227-1233 ISSN 0003-3472 Institutional research plan: CEZ:AV0Z60930519 Keywords : alternative mating tactics * European bitterling * mating system * sexual conflict * sexual selection * sneaking * sperm competition * sperm economy Subject RIV: EG - Zoology Impact factor: 2.890, year: 2009

EVALUATING THE COMPETITION DYNAMICS OF CONTAINER PORTS IN THE NORTH ADRIATIC

OpenAIRE

Twrdy, Elen; Batista, Milan

2014-01-01

World trade has changed in the last decade and the container traffic flows are oriented towards several parts of the European continent. A European container port system is not a homogenous set of ports, but is established of several large ports (Rotterdam, Hamburg, Algeciras...) and a large number of medium- and small-sized ports. North Adriatic (NA) ports belong to this category of ports and in this paper we have analysed the container flows and the throughput attained in these ports.

Climate change effects on shallow lakes: design and preliminary results of a cross-European climate gradient mesocosm experiment

Czech Academy of Sciences Publication Activity Database

Landkildehus, F.; Søndergaard, M.; Beklioglu, M.; Adrian, R.; Angeler, D.G.; Hejzlar, Josef; Papastergiadou, E.; Zingel, P.; Çakiroğlu, A.I.; Scharfenberger, U.; Drakare, S.; Nõges, T.; Šorf, Michal; Stefanidis, K.; Tavşanoğlu, Ü.N.; Trigal, C.; Mahdy, A.; Papadaki, C.; Tuvikene, L.; Larsen, S.E.; Kernan, M.; Jeppesen, E.

2014-01-01

Roč. 63, č. 2 (2014), s. 71-89 ISSN 1736-602X EU Projects: European Commission(XE) 244121 - REFRESH Institutional support: RVO:60077344 Keywords : climate change * nutrient enrichment * water level effects * macroecology * REFRESH project * macrophytes * metabolism Subject RIV: DA - Hydrology ; Limnology

Analyses of State and Density of Traffic in the Port of Dubrovnik- Gruz

Directory of Open Access Journals (Sweden)

Vedran Jelavić

2008-05-01

Full Text Available Port of Gruž is located in a naturally protected bay whichcan accommddate the biggest passenger cmisers and RO-ROships that sail the Mediterranean. At the same time there aremore yachts/'visiting the port because of the vicinity of theDubrovnik historic sites. The frequency of maritime traffic andother mariti~e services is rapidly increasing and sometimescausing owfrload in the summer months. The sizes of all kindsof ships a~d yachts that manoeuvre in the port are getting bigger.The itinerary for the following seasons and prognoses till2010 stress the increase in the number of ships, vehicles andpassengers. The activities at the passenger terminal are in progressat the moment and after completing all the works the passengerpier will be about BOOm long with the depth of 12m.Handling of cmisers will therefore be much easier and more efficient.Another benefit for the bay will be the construction ofthe Yacht marina and marina for the local boats all along thesouth-west coast of the bay. Considering summer peaks in allkinds of traffic it is necessary to analyse the state of all relevanttraffic factors and the density of traffic in order to organise safeand smooth flow of ships, vehicles and passengers through theport of Dubrovnik - Gmi.

Antimalarial activity of the bisquinoline trans-N1,N2-bis (7- chloroquinolin-4-yl)cyclohexane-1,2-diamine: Comparison of two stereoisomers and detailed evaluation of the S,S enantiomer, Ro 47-7737

NARCIS (Netherlands)

Ridley, R.G.; Matile, H.; Jaquet, C.; Dorn, A.; Hofheinz, W.; Leupin, W.; Masciadri, R.; Theil, F.P.; Richter, W.F.; Girometta, M.A.; Guenzi, A.; Urwyler, H.; Gocke, E.; Potthast, J.M.; Csato, M.; Thomas, A.; Peters, W.

1997-01-01

The S,S enantiomer of the bisquinoline trans-N1,N2-bis(7- chloroquinolin-4-yl)cyclohexane-1,2-diamine, Ro 47-7737, is significantly more potent against chloroquine-resistant Plasmodium falciparum than the R,R enantiomer and the previously described racemate. Both the enantiomers and the racemate are

Effects of simulated historical tree litter raking on the understorey vegetation in a central European forest

Czech Academy of Sciences Publication Activity Database

Vild, Ondřej; Kalwij, Jesse; Hédl, Radim

2015-01-01

Roč. 18, č. 4 (2015), s. 569-578 ISSN 1402-2001 R&D Projects: GA AV ČR IAA600050812 EU Projects: European Commission(XE) 278065 - LONGWOOD Institutional support: RVO:67985939 Keywords : conservation management * litter raking * species diversity Subject RIV: EF - Botanics Impact factor: 2.308, year: 2015

Technical feasibility of using gallery intakes for seawater RO facilities, northern Red Sea coast of Saudi Arabia: The King Abdullah Economic City site

KAUST Repository

Dehwah, Abdullah

2013-02-13

The Kingdom of Saudi Arabia is dependent on desalination of seawater to provide new water supplies for the future. Desalination is expensive and it is very important to reduce the cost and lower the energy consumption. Most seawater reverse osmosis facilities use open-ocean intakes, which require extensive pretreatment processes to remove particulate and biological materials that cause operating problems such as membrane fouling or shutdown during algal blooms. Subsurface systems, using the concept of riverbank filtration, can be used as intakes. These systems include wells of various designs and galleries that provide natural filtration and biological treatment to improve the quality of feed water before it enters the desalination plant. This reduces operating cost, lowers chemical and energy consumption, and reduces environmental impacts. Technical feasibility of gallery-type intakes, beach and seabed types, for use as intakes to seawater reverse osmosis (RO) facilities was evaluated along the northern Red Sea shoreline of Saudi Arabia. The geological characteristics of the offshore ocean bottom were found to be favorable for the development of seabed gallery systems, but the shoreline geology was not adequate for the development of beach gallery intakes. One of the potentially favorable sites for a seabed gallery system was located in the nearshore area at King Abdullah Economic City (KAEC). Detailed investigation of the site hydrology (tides and wave action), sediment grain size characteristics, and sediment hydraulic conductivity, and access for construction were assessed. It was determined that seabed gallery development is favorable at the site. Based on the seawater that has a salinity of about 41,000 mg/L and a conversion rate of 40%, a conservatively designed gallery cell with dimensions of 100 by 50 m would produce about 25,000 m3/day of filtered seawater and seven cells (6 primary and 1 standby) could support a 60,000 m3/day (permeate) seawater RO plant

Present status of and subjects on the industrial utilization of polymer separation membranes. Japan`s first largest sea water desalination plant by RO; Kobunshi bunrimaku no sangyo riyo no genjo to kadai. Zosui bun`ya ni okeru maku riyo

Energy Technology Data Exchange (ETDEWEB)

Furuichi, M. [Kurita Water Industries Ltd., Tokyo (Japan)

1998-07-05

The utilization in Japan and abroad is discussed of desalination methods using evaporation, reverse osmosis (RO) membranes, and electrodialysis membranes, out of various desalination techniques for seawater and others containing more salt. A new seawater desalination plant built in Okinawa, Japan, is outlined, and the future trend of Japan`s efforts for desalination is predicted. The said plant in Okinawa is the largest ever built in this country, and occupies 4th or 5th place in terms of capacity among similar facilities across the world. It was completed in April, 1997, and produces pure water at a rate of 40,000m{sup 3}/day. This plant, operating on RO, comprises eight RO membrane units each capable of 5131{sup 3}/day. The membranes are of the spiral type, consisting of Toray`s crosslinked aramid-base composite membranes and Nitto Denko`s membranes composed totally of crosslinked aromatic polyamide. The greatest of the pending tasks is to reduce the desalination cost. As for the operating cost of the desalination facility at the current stage, it costs 120-130 yen/m{sup 3} on the 40,000m{sup 3}/day scale, and the power cost occupies approximately 60% of the total operating cost. It is concluded that the consumption of electric power and chemicals per pure water produced have to be reduced. 8 refs., 5 figs., 5 tabs.

Return on Scientific Investment - RoSI: a PMO dynamical index proposal for scientific projects performance evaluation and management.

Science.gov (United States)

Caous, Cristofer André; Machado, Birajara; Hors, Cora; Zeh, Andrea Kaufmann; Dias, Cleber Gustavo; Amaro Junior, Edson

2012-01-01

To propose a measure (index) of expected risks to evaluate and follow up the performance analysis of research projects involving financial and adequate structure parameters for its development. A ranking of acceptable results regarding research projects with complex variables was used as an index to gauge a project performance. In order to implement this method the ulcer index as the basic model to accommodate the following variables was applied: costs, high impact publication, fund raising, and patent registry. The proposed structured analysis, named here as RoSI (Return on Scientific Investment) comprises a pipeline of analysis to characterize the risk based on a modeling tool that comprises multiple variables interacting in semi-quantitatively environments. This method was tested with data from three different projects in our Institution (projects A, B and C). Different curves reflected the ulcer indexes identifying the project that may have a minor risk (project C) related to development and expected results according to initial or full investment. The results showed that this model contributes significantly to the analysis of risk and planning as well as to the definition of necessary investments that consider contingency actions with benefits to the different stakeholders: the investor or donor, the project manager and the researchers.

Dynamic Young Stars and their Disks: A Temporal View of NGC 2264 with Spitzer and CoRoT*

Directory of Open Access Journals (Sweden)

Cody Ann Marie

2014-01-01

Full Text Available Variability is a signature feature of young stars. Among the well known light curve phenomena are periodic variations attributed to surface spots and irregular changes associated with accretion or circumstellar disk material. While decades of photometric monitoring have provided a framework for classifying young star variability, we still know surprisingly little about its underlying mechanisms and connections to the surrounding disks. In the past few years, dedicated photometric monitoring campaigns from the ground and space have revolutionized our view of young stars in the time domain. We present a selection of optical and infrared time series from several recent campaigns, highlighting the Coordinated Synoptic Investigation of NGC 2264 (“CSI 2264”– a joint30-day effort with the Spitzer, CoRoT, and MOST telescopes. The extraordinary photometric precision, high cadence, and long time baseline of these observations is now enabling correlation of variability properties at very different wavelengths, corresponding to locations from the stellar surface to the inner 0.1 AU of the disk. We present some results of the CSI 2264 program, including new classes of optical/infrared behavior. Further efforts to tie observed variability features to physical models will provide insights into the inner disk environment at a time when planet formation may be underway.

Svět akademií. Rodina Jirečkova, Josef Hlávka a organizace české vědy (K 100. výročí úmrtí J. Hlávky)

Czech Academy of Sciences Publication Activity Database

Havlíková, Lubomíra

2008-01-01

Roč. 94, č. 4 (2008), s. 645-656 ISSN 0037-6922 Institutional research plan: CEZ:AV0Z90920516 Keywords : history of science * Hlávka, Josef (1831-1908) * Jireček, Hermenegild (1827-1909) * Jireček, Josef (1825-1888) * Jireček, Konstantin (1854-1918) * academy Subject RIV: AB - History