Sample records for european downstream oil

  1. European downstream oil industry safety performance : statistical summary of reported incidents, 1998 (United States)


    This report is the fifth by CONCAWE reviewing the safety performance of the downstream oil industry in Europe. The area of coverage is primarily the EU, EEA and Hungary, but for some companies the data for other European countries such as Poland, Cze...

  2. European downstream oil industry safety performance : statistical summary of reported incidents, 1996 (United States)


    This report is the third by CONCAWE reviewing the safety performance of the downstream oil industry in Western Europe. It includes the results of 28 companies which together represent over 90% of the oil refining capacity in Europe. It is therefore a...

  3. European downstream oil industry safety performance : statistical summary of reported incidents, 1997 and overview 1993 to 1997 (United States)


    This report is the fourth by CONCAWE reviewing the safety performance of the downstream ol industry in Western Europe. It includes the results of 27 companies which together represent over 90% of the oil refining capacity in the region. Of the 27 com...

  4. Recent hydrocarbon developments in Latin America: Key issues in the downstream oil sector

    Energy Technology Data Exchange (ETDEWEB)

    Wu, K.; Pezeshki, S.


    This report discusses the following: (1) An overview of major issues in the downstream oil sector, including oil demand and product export availability, the changing product consumption pattern, and refineries being due for major investment; (2) Recent upstream developments in the oil and gas sector in Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, Peru, Trinidad and Tobago, and Venezuela; (3) Recent downstream developments in the oil and gas sector in Argentina, Chile, Colombia, Ecuador, Mexico, Peru, Cuba, and Venezuela; (4) Pipelines in Argentina, Bolivia, Brazil, Chile, and Mexico; and (5) Regional energy balance. 4 figs., 5 tabs.

  5. Temporal progression in migratory status and sexual maturation in European silver eels during downstream migration

    NARCIS (Netherlands)

    Palstra, A.P.; Guerrero, M.A.; Klein Breteler, J.G.P.; Thillart, G.E.E.J.M.


    The onset of downstream migration of European eels is accompanied by a cessation of feeding and the start of sexual maturation which stresses the link between metabolism and sexual maturation, also suggesting an important role for exercise. Exercise has been tested with eels in swim tunnels and was

  6. Microalgae Oil Production: A Downstream Approach to Energy Requirements for the Minamisoma Pilot Plant

    Directory of Open Access Journals (Sweden)

    Dhani S. Wibawa


    Full Text Available This study investigates the potential of microalgae oil production as an alternative renewable energy source, in a pilot project located at Minamisoma City in the Fukushima Prefecture of Japan. The algal communities used in this research were the locally mixed species, which were mainly composed of Desmodesmus collected from the Minamisoma pilot project. The microalgae oil-production processes in Minamisoma consisted of three stages: cultivation, dewatering, and extraction. The estimated theoretical input-energy requirement for extracting oil was 137.25 MJ to process 50 m3 of microalgae, which was divided into cultivation 15.40 MJ, centrifuge 13.39 MJ, drum filter 14.17 MJ, and hydrothermal liquefaction (HTL 94.29 MJ. The energy profit ratio (EPR was 1.41. The total energy requirement was highest in the HTL process (68% followed by cultivation (11% and the drum filter (10%. The EPR value increased along with the yield in the cultivation process. Using HTL, the microalgae biomass could be converted to bio-crude oil to increase the oil yield in the extraction process. Therefore, in the long run, the HTL process could help lower production costs, due to the lack of chemical additions, for extracting oil in the downstream estimation of the energy requirements for microalgae oil production.

  7. Trading in the downstream European gas market. A successive oligopoly approach

    Energy Technology Data Exchange (ETDEWEB)

    Boots, M.G. [ECN Policy Studies, Petten (Netherlands); Rijkers, F.A.M. [Office of Energy Regulation DTe, Den Haag (Netherlands); Hobbs, B.F. [Whiting School of Engineering, Johns Hopkins University, Baltimore, MD (United States)


    A model of successive oligopoly is applied to the European natural gas market. The model has a two-level structure, in which Cournot producers are also Stackelberg leaders with respect to traders, who may be Cournot oligopolists or price takers. Several conclusions emerge. First, successive oligopoly (''double marginalization'') yields higher prices and lower consumer welfare than if oligopoly exists only on one level. Second, due to the high concentration of traders, prices are distorted more by market power in trading than in production. Third, trader profits depend on whether producers can price discriminate among consuming sectors; if so, producers collect a greater share of the profits. Finally, when traders increase in number, prices approach competitive levels. Thus, it is important to prevent concentration in the downstream gas market. If oligopolistic trading cannot be prevented, vertical integration should not be discouraged, especially if it would increase the number of traders.

  8. Protection of LDL from oxidation by olive oil polyphenols is associated with a downregulation of CD40-ligand expression and its downstream products in vivo in humans. (United States)

    Castañer, Olga; Covas, María-Isabel; Khymenets, Olha; Nyyssonen, Kristiina; Konstantinidou, Valentini; Zunft, Hans-Franz; de la Torre, Rafael; Muñoz-Aguayo, Daniel; Vila, Joan; Fitó, Montserrat


    Recently, the European Food Safety Authority approved a claim concerning the benefits of olive oil polyphenols for the protection of LDL from oxidation. Polyphenols could exert health benefits not only by scavenging free radicals but also by modulating gene expression. We assessed whether olive oil polyphenols could modulate the human in vivo expressions of atherosclerosis-related genes in which LDL oxidation is involved. In a randomized, crossover, controlled trial, 18 healthy European volunteers daily received 25 mL olive oil with a low polyphenol content (LPC: 2.7 mg/kg) or a high polyphenol content (HPC: 366 mg/kg) in intervention periods of 3 wk separated by 2-wk washout periods. Systemic LDL oxidation and monocyte chemoattractant protein 1 and the expression of proatherogenic genes in peripheral blood mononuclear cells [ie, CD40 ligand (CD40L), IL-23α subunit p19 (IL23A), adrenergic β-2 receptor (ADRB2), oxidized LDL (lectin-like) receptor 1 (OLR1), and IL-8 receptor-α (IL8RA)] decreased after the HPC intervention compared with after the LPC intervention. Random-effects linear regression analyses showed 1) a significant decrease in CD40, ADRB2, and IL8RA gene expression with the decrease of LDL oxidation and 2) a significant decrease in intercellular adhesion molecule 1 and OLR1 gene expression with increasing concentrations of tyrosol and hydroxytyrosol in urine. In addition to reducing LDL oxidation, the intake of polyphenol-rich olive oil reduces CD40L gene expression, its downstream products, and related genes involved in atherogenic and inflammatory processes in vivo in humans. These findings provide evidence that polyphenol-rich olive oil can act through molecular mechanisms to provide cardiovascular health benefits. This trial was registered at as ISRCTN09220811.

  9. Oil price shocks and European industries

    NARCIS (Netherlands)

    Scholtens, Bert; Yurtsever, Cenk

    We investigate the impact of oil price shocks at the industry level in the Euro area for the period 1983-2007. We use different oil price specifications and use dynamic VAR models and multivariate regression to investigate how 38 different industries respond to oil price shocks. We pay specific

  10. EUFODOS: European Forest Downstream Services – Improved Information on Forest Structure and Damage

    Directory of Open Access Journals (Sweden)

    M. Hirschmugl


    Full Text Available Forests play a key role in the European economy and environment. This role incorporates ecological functions which can be affected by the occurrence of insect infestations, forest fire, heavy snowfall or windfall events. Local or Regional Authorities (LRAs thus require detailed information on the degradation status of their forests to be able to take appropriate measures for their forest management plans. In the EUFODOS project, state-of-the-art satellite and laser scanning technologies are used to provide forest authorities with cost-effective and comprehensive information on forest structure and damage. One of the six test sites is located in the Austrian province of Styria where regional forest authorities have expressed a strong need for detailed forest parameters in protective forest. As airborne laser-scanning data is available, it will be utilized to derive detailed forest parameters such as the upper forest border line, tree height, growth classes, forest density, vertical structure or volume. At the current project status, the results of (i the forest border line, (ii the segmentation of forest stands and (iii the tree top detection are available and presented including accuracy assessment and interim results are shown for timber volume estimations. The final results show that the forest border can be mapped operationally with an overall accuracy of almost 99% from LiDAR data. For the segmentation of forest stands, a comparison of the automatically derived result with visual-manual delineation showed in general a more detailed segmentation result, but for all visual-manual segments a congruence of 87% within a 4 m buffer. Tree top detections were compared to stem numbers estimated based on angle-count samplings in a field campaign, which led to a correlation coefficient (R of 0.79.

  11. Essential oil diversity of European Origanum vulgare L. (Lamiaceae). (United States)

    Lukas, Brigitte; Schmiderer, Corinna; Novak, Johannes


    This investigation focused on the qualitative and quantitative composition of essential oil compounds of European Origanum vulgare. Extracts of 502 individual O. vulgare plants from 17 countries and 51 populations were analyzed via GC. Extracts of 49 plants of 5 populations of Israeli Origanum syriacum and 30 plants from 3 populations of Turkish Origanum onites were included to exemplify essential oil characteristics of 'high-quality' oregano. The content of essential oil compounds of European O. vulgare ranged between 0.03% and 4.6%. The monoterpenes were primarily made up of sabinene, myrcene, p-cymene, 1,8-cineole, β-ocimene, γ-terpinene, sabinene hydrate, linalool, α-terpineol, carvacrol methyl ether, linalyl acetate, thymol and carvacrol. Among the sesquiterpenes β-caryophyllene, germacrene D, germacrene D-4-ol, spathulenol, caryophyllene oxide and oplopanone were often present in higher amounts. According to the proportions of cymyl-compounds, sabinyl-compounds and the acyclic linalool/linalyl acetate three different main monoterpene chemotypes were defined. The cymyl- and the acyclic pathway were usually active in plants from the Mediterranean climate whereas an active sabinyl-pathway was a characteristic of plants from the Continental climate. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. The European Community and crisis adaptation: The impact of the 1973 oil crisis on European integration

    Energy Technology Data Exchange (ETDEWEB)

    Mahurin, R.P.


    This study investigates relationships that emerged between European Economic Community and Arab League nations during the period 1970-1978, with special attention to the period immediately following the October 1973 Arab-Israeli war and the Arab oil embargo of 1973-74. The central argument is that European integration can be measured and understood from three different levels of analysis: not only the systems or supranational level (to which neofunctionalists and federalists have largely confined their investigations), but from the nation-state and the subnational levels also. This view is justified in the context of complex interdependencies in the work of Joseph Nye and Robert Keohane. From this perspective, nation-state and subnational-level data take on a new importance. This study collected data on the nature, level, and intensity of contracts between actors within each of these three levels. The study finds at all these levels strong evidence of increased collective and convergent activity which, in the context of complex interdependencies, points to a complex but clearly advancing process of European integration during the period under investigation.

  13. European oil product supply modelling; Modelisation de l`offre de produits petroliers en Europe

    Energy Technology Data Exchange (ETDEWEB)

    Saint-Antonin, V


    Over the last few years, trends in European oil product consumption (in terms of level as structure and quality) has important implications of the refining industry. In this context, the purpose of this thesis consists in building a mathematical programming model applied to the European refineries in order to determine oil product supply prices, European refining industry investments and oil product exchanges of the European Union. The first part presents the reason for our choice for a long-term aggregate multi-refineries linear programming model, based on European refineries characteristics and the objectives of our model. Its dual properties are studied in detail and we focus particularly on the European exchange modelling. In the second part, an analysis of the European refining trends leads us to identify parameters and variables of the model that are essential to the aggregate representation of the European oil product supply. The third part is devoted to the use of this model, regarding two scenarios of increasingly stringent specifications for gasoline and diesel oil. Our interest for these products is due to their important share of the European oil product consumption and the not insignificant responsibility of the transport sector for atmospheric pollution. Finally, in order to have the use of an overall picture of the European refining industry, we build a regression model summarizing, though a few equations, the main relations between the major endogenous and exogenous variables o the LP model. Based on pseudo-data, this kind of model provides a simple and robust representation of the oil product supply. But a more specialized analysis of the refining industry operations, turning on a technical assessment of processing units, is reliant on the use of an optimization model such as the model we have built. (author) 102 refs.

  14. European Atlantic: the hottest oil spill hotspot worldwide

    NARCIS (Netherlands)

    Rodriguez Vieites, D.; Nieto-Roman, S.; Palanca, A.; Ferrer, X.; Vences, M.


    Oil spills caused by maritime transport of petroleum products are still an important source of ocean pollution, especially in main production areas and along major transport routes. We here provide a historical and geographic analysis of the major oil spills (>700 tonnes) since 1960. Spills were

  15. Composition of the essential oil of Salvia officinalis L. from various European countries. (United States)

    Raal, Ain; Orav, Anne; Arak, Elmar


    Variations in the essential oil composition of Salvia officinalis L. growing in Estonia and in other European countries were determined. The oils were obtained in yields of 2.2-24.8 mL kg(-1). In three samples, the content of essential oil did not conform to the EP standard (10 mL kg(-1)). Variations in the essential oil composition of sage were studied using capillary gas chromatographic methods. A total of 40 components were identified. The principal components in the sage oils were 1,8-cineole, camphor, alpha-thujone, beta-thujone, borneol, and viridiflorol. The chemotypes of sage were not determined in investigated samples. The concentration of the main compounds in the drugs cultivated in Estonia varied in about the same range as the concentrations of these compounds in the oils of drugs obtained from other countries. The comparatively high concentration of toxic thujones seem to be characteristic to sage leaves cultivated in Estonia.

  16. Self-similar distribution of oil spills in European coastal waters

    Energy Technology Data Exchange (ETDEWEB)

    Redondo, Jose M; Platonov, Alexei K [Departament de Fisica Aplicada, Universidad Politecnica de Catalunya C/ J G Salgado s/n, Campus Nord, Modul B-4, E-08034, Barcelona (Spain)], E-mail:


    Marine pollution has been highlighted thanks to the advances in detection techniques as well as increasing coverage of catastrophes (e.g. the oil tankers Amoco Cadiz, Exxon Valdez, Erika, and Prestige) and of smaller oil spills from ships. The new satellite based sensors SAR and ASAR and new methods of oil spill detection and analysis coupled with self-similar statistical techniques allow surveys of environmental pollution monitoring large areas of the ocean. We present a statistical analysis of more than 700 SAR images obtained during 1996-2000, also comparing the detected small pollution events with the historical databases of great marine accidents during 1966-2004 in European coastal waters. We show that the statistical distribution of the number of oil spills as a function of their size corresponds to Zipf's law, and that the common small spills are comparable to the large accidents due to the high frequency of the smaller pollution events. Marine pollution from tankers and ships, which has been detected as oil spills between 0.01 and 100 km{sup 2}, follows the marine transit routes. Multi-fractal methods are used to distinguish between natural slicks and spills, in order to estimate the oil spill index in European coastal waters, and in particular, the north-western Mediterranean Sea, which, due to the influence of local winds, shows optimal conditions for oil spill detection.

  17. Economic feasibility of biochemical processes for the upgrading of crudes and the removal of sulfur, nitrogen, and trace metals from crude oil -- Benchmark cost establishment of biochemical processes on the basis of conventional downstream technologies. Final report FY95

    Energy Technology Data Exchange (ETDEWEB)

    Premuzic, E.T.


    During the past several years, a considerable amount of work has been carried out showing that microbially enhanced oil recovery (MEOR) is promising and the resulting biotechnology may be deliverable. At Brookhaven National Laboratory (BNL), systematic studies have been conducted which dealt with the effects of thermophilic and thermoadapted bacteria on the chemical and physical properties of selected types of crude oils at elevated temperatures and pressures. Current studies indicate that during the biotreatment several chemical and physical properties of crude oils are affected. The oils are (1) emulsified; (2) acidified; (3) there is a qualitative and quantitative change in light and heavy fractions of the crudes; (4) there are chemical changes in fractions containing sulfur compounds; (5) there is an apparent reduction in the concentration of trace metals; and (6) the qualitative and quantitative changes appear to be microbial species dependent; and (7) there is a distinction between biodegraded and biotreated oils. The downstream biotechnological crude oil processing research performed thus far is of laboratory scale and has focused on demonstrating the technical feasibility of downstream processing with different types of biocatalysts under a variety of processing conditions. Quantitative economic analysis is the topic of the present project which investigates the economic feasibility of the various biochemical downstream processes which hold promise in upgrading of heavy crudes, such as those found in California, e.g., Monterey-type, Midway Sunset, Honda crudes, and others.

  18. Trans fatty acids in dietary fats and oils from 14 European countries : the TRANSFAIR study

    NARCIS (Netherlands)

    Aro, A.; Amelsvoort, J. van; Becker, W.; Erp-Baart, M.A. van; Kafatos, A.; Leth, T.; Poppel, G. van


    The fatty acid composition of dietary fats and oils from 14 European countries was analyzed with particular emphasis on isomerictransfatty acids. The proportion oftransfatty acids in typical soft margarines and low-fat spreads ranged between 0.1 and 17% of total fatty acids and that

  19. The impact of oil prices on GDP in European countries: An empirical investigation based on asymmetric cointegration

    Energy Technology Data Exchange (ETDEWEB)

    Lardic, Sandrine [Paris Univ., MODEM-CNRS, Paris, 10 (France); Mignon, Valerie [Paris Univ., THEMA-CNRS, Paris, 10 (France); CEPII, Paris (France)


    This paper investigates the existence of a long-term relationship between oil prices and GDP in 12 European countries. To account for the fact that economic activity responds asymmetrically to oil price shocks, we propose an approach based on asymmetric cointegration. Our results show that, while standard cointegration is rejected, there is evidence for asymmetric cointegration between oil prices and GDP in the majority of the considered European countries. (Author)

  20. Characterization of european virgin olive oils using fatty acids

    Directory of Open Access Journals (Sweden)

    Alonso García, María V.


    Full Text Available The possibility of discriminating between extra virgin olive oils from different regions of Spain, Italy and Portugal, by means of their fatty acid content, has been investigated. A dendrogram allowed discrimination between the oils starting from their initial grouping and progressing to differentiation on the basis of regions. Multivariant statistical analyses were applied to determine the actual discriminatory capacity of this group of compounds. The confidence associated with the final discrimination was ascertained using the theory of evidence.

    Se ha estudiado la posibilidad de discriminación entre aceites de oliva virgen procedentes de diferentes regiones de España, Italia y Portugal, mediante sus ácidos grasos. Para llevar a cabo la discriminación entre los aceites, desde su agrupación inicial hasta la diferenciación por regiones, se empleó una estructura arborescente. Fueron aplicados procedimientos estadísticos multivariantes para determinar la capacidad discriminante actual de este grupo de compuestos. La certeza asociada a la discriminación final fue calculada mediante la teoría de la evidencia.

  1. Operational oil spill trajectory modelling using HF radar currents: A northwest European continental shelf case study. (United States)

    Abascal, Ana J; Sanchez, Jorge; Chiri, Helios; Ferrer, María I; Cárdenas, Mar; Gallego, Alejandro; Castanedo, Sonia; Medina, Raúl; Alonso-Martirena, Andrés; Berx, Barbara; Turrell, William R; Hughes, Sarah L


    This paper presents a novel operational oil spill modelling system based on HF radar currents, implemented in a northwest European shelf sea. The system integrates Open Modal Analysis (OMA), Short Term Prediction algorithms (STPS) and an oil spill model to simulate oil spill trajectories. A set of 18 buoys was used to assess the accuracy of the system for trajectory forecast and to evaluate the benefits of HF radar data compared to the use of currents from a hydrodynamic model (HDM). The results showed that simulated trajectories using OMA currents were more accurate than those obtained using a HDM. After 48h the mean error was reduced by 40%. The forecast skill of the STPS method was valid up to 6h ahead. The analysis performed shows the benefits of HF radar data for operational oil spill modelling, which could be easily implemented in other regions with HF radar coverage. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  2. Olive oil intake and CHD in the European Prospective Investigation into Cancer and Nutrition Spanish cohort. (United States)

    Buckland, Genevieve; Travier, Noemie; Barricarte, Aurelio; Ardanaz, Eva; Moreno-Iribas, Conchi; Sánchez, María-José; Molina-Montes, Esther; Chirlaque, María Dolores; Huerta, José María; Navarro, Carmen; Redondo, Maria Luisa; Amiano, Pilar; Dorronsoro, Miren; Larrañaga, Nerea; Gonzalez, Carlos A


    Olive oil is well known for its cardioprotective properties; however, epidemiological data showing that olive oil consumption reduces incident CHD events are still limited. Therefore, we studied the association between olive oil and CHD in the European Prospective Investigation into Cancer and Nutrition (EPIC) Spanish cohort study. The analysis included 40 142 participants (38 % male), free of CHD events at baseline, recruited from five EPIC-Spain centres from 1992 to 1996 and followed up until 2004. Baseline dietary and lifestyle information was collected using interview-administered questionnaires. Cox proportional regression models were used to assess the relationship between validated incident CHD events and olive oil intake (energy-adjusted quartiles and each 10 g/d per 8368 kJ (2000 kcal) increment), while adjusting for potential confounders. During a 10·4-year follow-up, 587 (79 % male) CHD events were recorded. Olive oil intake was negatively associated with CHD risk after excluding dietary mis-reporters (hazard ratio (HR) 0·93; 95 % CI 0·87, 1·00 for each 10 g/d per 8368 kJ (2000 kcal) and HR 0·78; 95 % CI 0·59, 1·03 for upper v. lower quartile). The inverse association between olive oil intake (per 10 g/d per 8368 kJ (2000 kcal)) and CHD was more pronounced in never smokers (11 % reduced CHD risk (P = 0·048)), in never/low alcohol drinkers (25 % reduced CHD risk (P culinary use of olive oil within the Mediterranean diet to reduce the CHD burden.

  3. Fish Oil Finishing Diet Maintains Optimal n-3 Long-Chain Fatty Acid Content in European Whitefish (Coregonus lavaretus). (United States)

    Suomela, Jukka-Pekka; Tarvainen, Marko; Kallio, Heikki; Airaksinen, Susanna


    This study examined the effect of substituting vegetable oil for fish oil in feed, with subsequent re-introduction of fish oil-rich feed (finishing feeding) in late stages of growth, on the fatty acids of cultivated European whitefish (Coregonus lavaretus). Restorative finishing feeding with fish oil-rich feed for 15 and 25 weeks was sufficient to change the total content of nutritionally valuable long-chain n-3 fatty acids, eicosapentaenoic acid (20:5n-3) and docosahexaenoic acid (22:6n-3), to correspond to that of fish fed the fish oil-rich feed throughout their lifespan. Under natural conditions, 15 and 25 weeks correspond to weight gains of 75% and 100% (i.e. doubling), respectively. Also, the fatty acid profile of the fish was restored after finishing periods of 15 and 25 weeks. Limiting the use of fish oil by lowering the overall fat content of the feed (no vegetable oil added) resulted in a decrease in the long-chain n-3 fatty acids. Based on the results, after receiving a vegetable oil-rich diet, restorative fish oil-rich feeding in the last stages of growth in European whitefish is nutritionally justified in order to balance nutritional gain for consumers with sustainable use of finite marine oils. The results encourage commercial efforts to further utilize and optimize finishing feeding practices.

  4. The impact of heavy and acid oil production in PETROBRAS downstream area; A influencia dos petroleos pesados e acidos no parque de refino da PETROBRAS

    Energy Technology Data Exchange (ETDEWEB)

    Perisse, Juarez Barbosa; Oddone, Maria Regina Rezende; Bela, Donizeti Aurelio Silva [PETROBRAS, Rio de Janeiro, RJ (Brazil)


    PETROBRAS is facing a great challenge processing heavy and acid oils. The low API of the more recent offshore discoveries leads to an increase in vacuum residue yields which is one important component of the fuel oil's 'pool'. The fuel oil demand is expected to decrease along the next years due to natural gas substitution and to environmental issues, generating exceeding fuel oil exportation at low prices. This paper will discuss World and PETROBRAS technological choices to process these oils meeting the required future demand and quality. A comparison among various residue conversion technologies is also presented in this paper focused on the reduction of fuel oil production and on the improvement of diesel / gasoline rate. Another important issue that will be discussed in this paper is related to the different solutions implemented all over the world to deal with the crude acidity problem and the solutions adopted by PETROBRAS. (author)

  5. Climate change, future Arctic Sea ice, and the competitiveness of European Arctic offshore oil and gas production on world markets. (United States)

    Petrick, Sebastian; Riemann-Campe, Kathrin; Hoog, Sven; Growitsch, Christian; Schwind, Hannah; Gerdes, Rüdiger; Rehdanz, Katrin


    A significant share of the world's undiscovered oil and natural gas resources are assumed to lie under the seabed of the Arctic Ocean. Up until now, the exploitation of the resources especially under the European Arctic has largely been prevented by the challenges posed by sea ice coverage, harsh weather conditions, darkness, remoteness of the fields, and lack of infrastructure. Gradual warming has, however, improved the accessibility of the Arctic Ocean. We show for the most resource-abundant European Arctic Seas whether and how a climate induced reduction in sea ice might impact future accessibility of offshore natural gas and crude oil resources. Based on this analysis we show for a number of illustrative but representative locations which technology options exist based on a cost-minimization assessment. We find that under current hydrocarbon prices, oil and gas from the European offshore Arctic is not competitive on world markets.

  6. Influence of crude oil exposure on cardiac function and thermal tolerance of juvenile rainbow trout and European sea bass. (United States)

    Anttila, Katja; Mauduit, Florian; Le Floch, Stéphane; Claireaux, Guy; Nikinmaa, Mikko


    Oil spills pose a threat to aquatic organisms. However, the physiological effects of crude oil on cardiac function and on thermal tolerance of juvenile fish are still poorly understood. Consequently, in this paper, we will present results of two separate experiments where we exposed juvenile rainbow trout and European sea bass to crude oil and made cardiac thermal tolerances and maximum heart rate (f Hmax) measurements after 1 week (rainbow trout) and 6-month recovery (sea bass). In both species, the f Hmax was lower in crude oil-exposed fish than in the control ones at temperatures below the optimum but this difference disappeared at higher temperatures. More importantly, the oil-exposed fish had significantly higher Arrhenius break point temperature for f Hmax, which gave an estimate for optimum temperature, than the control fish in both species even though the exposure conditions and recovery times differed between species. The results indicated that exposure of juvenile fish to crude oil did not have a significant negative impact upon their cardiac performance in high temperatures and upper thermal tolerance increased when the fish were tested 1 week or 6 months after the exposure. Our findings suggest that the cardiac function and thermal tolerance of juvenile fish are relatively resistant to a crude oil exposure.

  7. Foam formation in a downstream digester of a cascade running full-scale biogas plant: Influence of fat, oil and grease addition and abundance of the filamentous bacterium Microthrix parvicella. (United States)

    Lienen, T; Kleyböcker, A; Verstraete, W; Würdemann, H


    The microbial community composition in a full-scale biogas plant fed with sewage sludge and fat, oil and grease (FOG) was investigated over a 15-month period, including two foam formation events. Addition of FOG as a substrate in the biogas plant together with high abundances of Microthrix parvicella were found to promote foam formation in the downstream digester of a cascade of two biogas digesters. Genetic fingerprinting and quantitative PCR (qPCR) indicated a higher abundance of M. parvicella in the digester, when the digestion process was accompanied by excessive foaming relative to the reference digesters without disturbance. The creation of foam depended on the introduced proportion of FOG and the abundance of M. parvicella. Furthermore, shifts in the abundance of M. parvicella in the biogas plant were observed within the 15-month monitoring period corresponding to its seasonal abundance in the sludge of the wastewater treatment plant (WWTP). Copyright © 2013 Elsevier Ltd. All rights reserved.

  8. Situation of European SMEs in the olive oil and table olive area. Survey.

    Directory of Open Access Journals (Sweden)

    Salvador, Javier


    Full Text Available A study of the situation of European Small and Medium Enterprises (SMEs in the olive oil and table olive sector is carried out in order to find their main needs in the following aspects: information, participation in Research, Development and Innovation (R+D+I programmes, Information and Communication Technologies (ICTs implementation, quality control, environmental impacts, etc. The data used in this study were obtained through questionnaires sent to SMEs in France, Germany, Greece, Italy, Portugal, Spain and Turkey. The results obtained show: a reasonable acceptance of ICTs, a high interest in training courses on the most recent and pertinent legislation, and in product quality improvement and marketing.En este trabajo, se realiza un estudio de la PYME europea en el sector olivarero para detectar las principales necesidades que tienen las empresas en información técnica, participación en proyectos de investigación, formación, Tecnologías de Información y Comunicación (TIC, calidad, impacto ambiental, etc. Los datos se obtuvieron a través de encuestas enviadas a empresas de Alemania, Francia, España, Grecia, Italia, Portugal y Turquía. Los resultados obtenidos muestran que las TIC tienen un nivel razonable de implantación en este sector industrial. Así mismo, las empresas encuestadas manifiestan tener gran interés en actividades de formación e información en la legislación relacionada con el sector, el control de calidad y el marketing.

  9. Effects of fish oil replacement by vegetable oil blend on digestive enzymes and tissue histomorphology of European sea bass (Dicentrarchus labrax) juveniles. (United States)

    Castro, Carolina; Couto, Ana; Pérez-Jiménez, Amalia; Serra, Cláudia R; Díaz-Rosales, Patricia; Fernandes, Rui; Corraze, Geneviève; Panserat, Stéphane; Oliva-Teles, Aires


    The impact of replacing circa 70% fish oil (FO) by a vegetable oil (VO) blend (rapeseed, linseed, palm oils; 20:50:30) in diets for European sea bass juveniles (IBW 96 ± 0.8 g) was evaluated in terms of activities of digestive enzymes (amylase, lipase, alkaline phosphatase, trypsin and total alkaline proteases) in the anterior (AI) and posterior (PI) intestine and tissue morphology (pyloric caeca-PC, AI, PI, distal intestine-DI and liver). For that purpose, fish were fed the experimental diets for 36 days and then liver and intestine were sampled at 2, 6 and 24 h after the last meal. Alkaline protease characterization was also done in AI and PI at 6 h post-feeding. Dietary VO promoted higher alkaline phosphatase activity at 2 h post-feeding in the AI and at all sampling points in the PI. Total alkaline protease activity was higher at 6 h post-feeding in the PI of fish fed the FO diet. Identical number of bands was observed in zymograms of alkaline proteases of fish fed both diets. No alterations in the histomorphology of PC, AI, PI or DI were noticed in fish fed the VO diets, while in the liver a tendency towards increased hepatocyte vacuolization due to lipid accumulation was observed. Overall, and with the exception of a higher intestine alkaline phosphatase activity, 70% FO replacement by a VO blend in diets for European sea bass resulted in no distinctive alterations on the postprandial pattern of digestive enzyme activities and intestine histomorphology.

  10. Russian Oil and Natural Gas: Strategic Culture and Security Implications of European Dependence

    National Research Council Canada - National Science Library

    Phillips, William M


    .... The first section looks into the past actions and strategic culture of Russia to determine if there exists a threat that Russia will deny energy resources to European countries for political or economic gain...

  11. Essential oils and chemical diversity of southeast European populations of Salvia officinalis L. (United States)

    Cvetkovikj, Ivana; Stefkov, Gjoshe; Karapandzova, Marija; Kulevanova, Svetlana; Satović, Zlatko


    The essential oils of 25 populations of Dalmatian sage (Salvia officinalis L.) from nine Balkan countries, including 17 indigenous populations (representing almost the entire native distribution area) and eight non-indigenous (cultivated or naturalized) populations were analyzed. Their essential-oil yield ranged from 0.25 to 3.48%. Within the total of 80 detected compounds, ten (β-pinene, 1,8-cineole, cis-thujone, trans-thujone, camphor, borneol, trans-caryophyllene, α-humulene, viridiflorol, and manool) represented 42.60 to 85.70% of the components in the analyzed essential oils. Strong positive correlations were observed between the contents of trans-caryophyllene and α-humulene, α-humulene and viridiflorol, and viridiflorol and manool. Principal component analysis (PCA) on the basis of the contents of the ten main compounds showed that four principal components had an eigenvalue greater than 1 and explained 79.87% of the total variation. Performing cluster analysis (CA), the sage populations could be grouped into four distinct chemotypes (A-D). The essential oils of 14 out of the 25 populations of Dalmatian sage belonged to Chemotype A and were rich in cis-thujone and camphor, with low contents of trans-thujone. The correlation between the essential-oil composition and geographic variables of the indigenous populations was not significant; hence, the similarities in the essential-oil profile among populations could not be explained by the physical proximity of the populations. Additionally, the southeastern populations tended to have higher EO yields than the northwestern ones. Copyright © 2015 Verlag Helvetica Chimica Acta AG, Zürich.

  12. European Unconventional Oil and Gas Assessment (EUOGA) - Development and application of a unified methodology

    NARCIS (Netherlands)

    Nelskamp, S.; Zijp, M.; Doornenbal, H.; Schovsbo, N.H.; Bocin-Dumitriu, A.


    Over the last decade, various international and national assessments of shale gas and shale oil resources for most EU-countries have been published. Due to methodological differences and in fundamental assumptions related to the quality and quantity of underlying geological information, these

  13. Validating a multi-biomarker approach with the shanny Lipophrys pholis to monitor oil spills in European marine ecosystems. (United States)

    Santos, M M; Solé, M; Lima, D; Hambach, B; Ferreira, A M; Reis-Henriques, M A


    Oil spills are an importance source of polycyclic aromatic hydrocarbons (PAHs) in the aquatic environment. Intertidal communities are particularly sensitive since most organisms from these ecosystems are sessile or present reduced mobility. Hence, it is important to validate the use of resident species as sentinels to characterize the impact of oil spills on the rocky shores and the improvement during the restoration process. Recently the advantages of using the shanny Lipophrys pholis in pollution monitoring within the northwestern Atlantic coast has been pointed out. Therefore, with the aim of further validating the use of L. pholis in pollution monitoring associated with petrogenic hydrocarbon contamination, a multi-biomarker approach study was carried out 1 week after a moderate oil spill from the waste treatment plant (WTP) of the major Portuguese refinery in the north of Portugal (Petrogal). Fish collected at 2 km from the accident displayed a significant induction of ethoxyresorufin-O-deethylase activity (EROD) and fluorescent aromatic compounds (FACs) in bile (up to a 5-fold induction) in comparison with the pre-spill scenario, and a 15% induction in erythrocytic nuclear abnormalities (ENA), a biomarker of genotoxicity. In contrast, no significant differences were recorded in the reference site. In order to better characterize the time-course accumulation of FACs in bile after a PAH insult, laboratory exposure of L. pholis to benzo[a]pyrene (B[a]P) was performed. A clear dose-response accumulation of B[a]P metabolites was observed that closely reflected nominal exposure concentrations already after 3d. Overall, the findings of the present study highlight the potential of L. pholis in pollution monitoring dealing not only with chronic contamination, but also with oil spill accidents of a moderate scale. Taking into consideration that EROD and FACs determinations in L. pholis are cost effective, rapid and easy to use, they offer a great potential to be

  14. Detailed and exhaustive study of the authentication of European virgin olive oils by SEXIA expert system

    Directory of Open Access Journals (Sweden)

    Aparicio, R.


    Full Text Available The authentication of extra virgin olive oils from different regions of Spain, Italy and Portugal, by means of their fatty acids, alcohols, sterols, methyl sterols and hydrocarbons content, has been investigated. Multivariate statistical methods and Evidence's Theory were applied. The comparative study shows greater predictive ability using this theory than the traditional statistical methods or expert systems that do not implement the possibility theory. A detailed and exhaustive study of Italian (Tuscany and Basilicata, Portuguese and Spanish virgin olive oils has been made. Geographically coloured maps of the studied regions are shown to strengthen the numerical results.

    Se ha estudiado la autentificación de aceites de oliva virgen de diferentes regiones de España, Italia y Portugal, por su contenido en ácidos grasos, alcoholes, esteroles, metil esteroles e hidrocarburos. Se aplicaron métodos estadísticos multivariantes junto a la Teoría de la Evidencia. El estudio mostró una mejora en la capacidad predictiva utilizando esta teoría frente a otros métodos o sistemas expertos que no implementan la teoría de la posibilidad. Se ha realizado un estudio detallado y exhaustivo con aceites de oliva virgen italianos (Toscana y Basilicata, portugueses y españoles. Los resultados numéricos se muestran sobre mapas geográficos de las diferentes regiones estudiadas.

  15. Il cambio dollaro/euro, il prezzo del petrolio e la Banca Centrale Europea (Dollar/Euro Exchange Rate, Oil Price and the European Central Bank

    Directory of Open Access Journals (Sweden)

    Stefano Sylos Labini


    Full Text Available In this paper an analysis on dollar/euro exchange rate, oil price and European Central Bank monetary policy is worked out. Firstly, data on the main variables related with the exchange rate and an equation to explain the variation of the exchange rate in the period March 1998-September 2000 are presented; secondly, the consequences of oil price growth and eurodevaluation on the US and European economies are taken into account; lastly, different policy strategies to stop eurodevaluation are discussed. The European Central Bank strategy, that consists of small increases of the interest rate, is not reaching any result. An alternative strategy is based on innovative public demand, that should be financed by European bonds using "central bank excess funds" as security. Public demand of infrastructures and new technologies should aim at reducing oil dependence and would stimulate growth and sustainable development in Europe, with positive effects on the exchange rate.       JEL Codes: E58, F31Keywords: Devaluation, Exchange Rates, Monetary

  16. Sectoral Structure Change Modeling of European Oil and Gas Producing Country’S Economy

    Directory of Open Access Journals (Sweden)

    Perepelkin Viacheslav Alexandrovich


    Full Text Available In this paper, we consider identifying features of sectoral structuring within the national economy that has definite foreign trade product specialization. Examination of the sector-specific division methodology enabled identification of its strong association with certain sector dominance in the economy. It is against this background that we offer an explanation for the delay in transferring from the post-Soviet to the applicable international classification of economic structure elements in Russia and Belarus. We perform analysis of the three-component P-S-T model (primary, secondary, tertiary sector using statistical and econometric methods and define properties of the sectoral shares dynamics in national economies of oil and gas producing countries. Analysis of the Russian and Norwegian economies’ intersectoral changes suggests that it is necessary for the government to develop and implement selective structural policy to overcome the existing structural disproportions.

  17. Geological and Geochemical Aspects of the Deep Origin of the Oil Fields of Volga-Ural Region in East-European Platform (United States)

    Plotnikova, Irina


    The study area for research is territory of Tatarstan and the South Tatarstan Arch located in the Volgo-Ural Region, which is an enigmatic crustal segment that occupies the eastern third of the East European Craton. The tectonic structure and history of geological development of this region are mainly defined by the fact that Tatarstan is a junction between several first-order tectonic elements. The present-day structure of the crystalline basement is a result of the evolution of the faults and blocks originally formed in Late Proterozoic times and those that partly originated from the older dislocations. The South Tatarstan arch contains Tatarstani largest oil fields - Romashkino, Novo-Elkhovo and Bavli. The analysis of areal and sectional distribution of the oil fields has allowed the tracing of the close link between the oil bearing capacity of the sedimentary cover and the block structure of the basement. All the oil fields above the South Tatarstan arch are controlled by the faults crosscutting the crystalline basement and the sedimentary cover. Oil accumulations in the lower productive strata of the sedimentary cover are confined to the basement zones with the maximum degree of tectonic fracturing and to the fault-intersection nodes. Genetic identity of oils and bitumens of the sedimentary cover, and the confinement of oil pools to tectonic faults confirm the role of the vertical migration it plays in the formation of commercial oil and bitumen accumulations in the Palaeozoic sedimentary sequences. The report contains data of analyse the distribution of oil in the sedimentary cover of Tatarstan in general and the location of the Romashkino oil field in particular from a new viewpoint, in their relation to the following factors: the composition and tectonomagmatic evolution of the crystalline basement in the pre-platform stage of its development; the fluid dynamic evolution in Phanerozoic times; and neotectonic processes. Cumulative oil production in Tatarstan

  18. Chemical composition of berry essential oils from Juniperus communis L. (Cupressaceae growing wild in Republic of Macedonia and assessment of the chemical composition in accordance to European Pharmacopoeia

    Directory of Open Access Journals (Sweden)

    Gjoshe Stefkov


    Full Text Available Chemical composition of fifteen samples of juniper essential oil was analyzed using GC/FID/MS method. Thirteen samples of berries were collected on different locations in south-western part , two of them in central-north region of Republic of Macedonia. The essential oils were obtained by hydrodistillation in a Clevenger type apparatus using official method of European Pharmacopoeia. GC/MS analysis revealed 74 identified components. The predominant fractions of the oils were monoterpene hydrocarbons representing 39.11- 73.38%. Great variability in the chemical composition and content of some components was observed. The most variable components were α-pinene (15.59-43.19%, β-pinene (1.65%-5.35%, β-myrcene (2.89%-26.50%, sabinene (2.80-11.77%, and limonene (2.90-4.46%. In the fraction of oxidized monoterpenes the most abundant was terpene-4-ol (trace - 6.32% followed by α-terpineol (0.18-1.63%. In the sesquiterpene fraction predominant components were: germacrene D (2.76-10.22%, β-elemene (1.13-3.40% and trans-(E-caryophyllene (1.8%- 4.05%. Twelve samples of Macedonian juniper oils comply with European Pharmacopoeia chemical composition requirements for juniper oil and three samples did not, due to lower amount of α-pinene.

  19. Hypermetabolic Conversion of Plant Oil into Water: Endothermic Biochemical Process Stimulated by Juvenile Hormone in the European Firebug, L.

    Directory of Open Access Journals (Sweden)

    Karel Sláma


    Full Text Available The physiological and biochemical mechanisms that enable insects to feed on dry food to secure enough water for larval growth were investigated. The study was carried out with a plethora of physiological methods, ranging from the simple volumetric determination of O 2 consumption and water intake to more advanced methods such as scanning microrespirography and thermovision imaging of insect's body temperature. The experiments were done on the European firebug, Pyrrhocoris apterus , which feeds exclusively on dry linden seeds. In order to survive, it needs to drink water or suck a sap from plants occasionally. It was found that the young larval instars compensate the occasional water deficiency by the increased production of metabolic water. The juvenile hormone (JH-dependent production of metabolic water, which was previously found in other species consuming dry food, was achieved in P. apterus by total metabolic combustion of the dietary lipid (neutral seed oil. The water-producing, hypermetabolic larvae were heated from inside by endothermic energy released from the uncoupling of oxidation from oxidative phosphorylation. The “warm”, hypermetabolic larvae burning the dietary oil into CO 2 and water showed the increased rates of respiratory metabolism. Microrespirographic recording of these larvae revealed the ratio of the respiratory quotient (RQ, CO 2 /O 2 of 0.7, which indicated the breakdown of a pure triglyceride. The warm hypermetabolic larvae could be easily spotted and distinguished from the “cold” larvae on the screen of a thermovision camera. The last instar larvae lacking the JH were always only cold. They metabolized a carbohydrate substrate exclusively (RQ = 1.0, while the dietary lipid was stored in the fat body. In comparison with the hypermetabolic larvae of some other species fed on dry food, which exhibited the highest rates of O 2 consumption ever recorded in a living organism (10–20 mL O 2 /g per hour, the metabolic

  20. Results of a European inter-laboratory comparison study on the determination of EU priority polycyclic aromatic hydrocarbons (PAHs) in edible vegetable oils

    Energy Technology Data Exchange (ETDEWEB)

    Simon, Rupert; Gomez Ruiz, Jose A.; Holst, Christoph von; Wenzl, Thomas [Institute for Reference Materials and Measurements, European Commission, Directorate General Joint Research Centre, Geel (Belgium); Anklam, Elke [Institute for Health and Consumer Protection, European Commission, Directorate General Joint Research Centre, Ispra (Italy)


    A collaborative study on the analysis for 15 + 1 EU priority PAHs in edible oils was organised to investigate the state-of-the-art of respective analytical methods. Three spiked vegetable oils, one contaminated native sunflower oil, and one standard solution were investigated in this study. The results of 52 laboratories using either high-performance liquid chromatography with fluorescence detection or gas chromatography with mass-selective detectors were evaluated by application of robust statistics. About 95% of the laboratories were able to quantify benzo[a]pyrene together with five other PAHs included in the commonly known list of 16 US-EPA PAHs. About 80% of the participants also quantified seven additional PAHs in most samples, two of which were benzo[b]fluoranthene and benzo[k]fluoranthene, which were also known from the EPA list. Only about 50% of the participants quantified cyclopenta[cd]pyrene, benzo[j]fluoranthene, and benzo[c]fluorene. The robust relative standard deviations of the submitted results without discrimination between the methods applied ranged between 100% for 5-methylchrysene in spiked olive oil and 11% for the same analyte in spiked sunflower oil. The results clearly showed that for these analytes the methods of analysis are not yet well established in European laboratories, and more collaborative trials are needed to promote further development and to improve the performances of the respective methods. (orig.)

  1. Analysis of Petroleum Downstream Industry Potential in Riau Province

    Directory of Open Access Journals (Sweden)

    Tomi Erfando


    Full Text Available Petroleum downstream industry in Riau Province is still not optimal. The data shows that from 98,892,755 barrels lifting oil each year only 62,050,000 barrels could be processed in refinery unit II Dumai operated by PT Pertamina. There is a potential of 35-40% of downstream industry. Indonesian Government through The Ministry of Energy and Mineral Resources declared the construction of a mini refinery to boost oil processing output in the downstream sector. A feasibility study of development plan mini refinery is needed. The study includes production capacity analysis, product analysis, development & operational refinery  analysis and economic analysis. The results obtained by the mini refinery capacity is planned to process crude oil 6000 BOPD with the products produced are gasoline, kerosene, diesel and oil. Investment cost consist of is capital cost US $ 104419784 and operating cost US $ 13766734 each year with net profit earned US $ 12330063/year and rate of return from investment 11.63%

  2. Evaluation of the European Union-United States oil and petroleum-based fuels trade potential in the context of the negotiated TTIP agreement

    Directory of Open Access Journals (Sweden)

    Olkuski Tadeusz


    Full Text Available The article evaluates the European Union-United States oil and petroleum-based fuels trade potential. The planned trade structure and balance according to IEA (International Energy Agency and IHS (IHS CERA scenarios, the projected volume of imports and exports, and differences in price levels and costs are presented. The projected potential of the trade volume, taking into account the possible impact of the Transatlantic Trade and Investment Partnership (TTIP, is also presented. The analysis has shown that the elimination of trade barriers between the European Union and the United States would be more beneficial to US refineries. Due to the higher import tariffs to the EU, the potential benefits of US exporters are higher than those of the EU exporters to the US. This confirms the fears of European negotiators that some aspects of the agreement will have a negative impact on European businesses. However, in the case of petroleum products the TTIP agreement will have a negligible impact on increasing the export volume.

  3. Oils

    Energy Technology Data Exchange (ETDEWEB)

    Cobbett, G.T.B.


    Crude petroleum having a density of 850 to 900 is purified with sulfuric acid, decanted, mixed with benzine or petrol, and again treated with sulfuric acid and decanted. The remaining acid and coloring-matter are removed by washing with water, or treating with oxalic acid, zinc carbonate, lead carbonate, calcium carbonate, or oxide of zinc. The product is used as a fuel for internal-combustion engines. Specifications No. 28,104, A.D. 1906, and No. 12,606, A.D. 1907, are referred to. According to the Provisional Specification, the process is applicable to shale or schist oil.

  4. Hydrodeoxygenation of bio-oils from Thermo-Catalytic Reforming - high energy efficient route to renewable gasoline and diesel: Paper presented at 24th European Biomass Conference and Exhibition, EUBCE 2016, Amsterdam, 6-9 June 2016


    Neumann, Johannes; Hornung, Andreas; Schmitt, Nina; Jäger, Nils; Conti, Roberto; Apfelbacher, Andreas; Daschner, Robert


    The agricultural production of energy crops is in competition to food production and discussed controversial. Therefore the academic and commercial research is focused on waste or residual biomass. A promising conversion technology for the production of high quality bio-oil, syngas and biochar from residual biomass is the Thermo-Catalytic Reforming process (TCR®); intermediate pyrolysis and integrated reforming. With an additional focus on biofuels for transportation, the downstream processin...

  5. Operational optimization in the downstream; Otimizacao operacional no downstream

    Energy Technology Data Exchange (ETDEWEB)

    Silberman, Luis; Cunha, Filipe Silveira Ramos da [Petroleo Ipiranga, Porto Alegre, RS (Brazil)


    On the present competitive down stream's market, there is a great necessity of optimization aiming to guarantee the best price and quality of our clients. Our goal is to attend these expectations while we guarantee an efficient operation. The greatest question is how far we are from the ideal model. This way, a lot of projects have been executed during the last years aiming the operational optimization of all our activities. We divide the projects in 4 areas: Logistic (new modals distribution), Transport (transport optimization - quality and more deliveries with less trucks), Client Support (Internet Ipiranga and Support Center), Distribution Terminals Productivity (automation and environment). This work intend to present our ideal, perfect and complete Downstream Operation model. We will talk about how close we are of this ideal model and we will present the projects that we had already developed and implanted on the automation of the terminals and the logistics area. (author)

  6. Auxin perception and downstream events. (United States)

    Strader, Lucia C; Zhao, Yunde


    Auxin responses have been arbitrarily divided into two categories: genomic and non-genomic effects. Genomic effects are largely mediated by SCFTIR1/AFB-Aux/IAA auxin receptor complexes whereas it has been postulated that AUXIN BINDING PROTEIN 1 (ABP1) controls the non-genomic effects. However, the roles of ABP1 in auxin signaling and plant development were recently called into question. In this paper, we present recent progress in understanding the SCFTIR1/AFB-Aux/IAA pathway. In more detail, we discuss the current understanding of ABP1 research and provide an updated view of ABP1-related genetic materials. Further, we propose a model in which auxin efflux carriers may play a role in auxin perception and we briefly describe recent insight on processes downstream of auxin perception. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. Microbial production of scleroglucan and downstream processing

    Directory of Open Access Journals (Sweden)

    Natalia Alejandra Castillo


    Full Text Available Synthetic petroleum-based polymers and natural plant polymers have the disadvantage of restricted sources, in addition to the non-biodegradability of the former ones. In contrast, eco-sustainable microbial polysaccharides, of low-cost and standardized production, represent an alternative to address this situation. With a strong global market, they attracted worldwide attention because of their novel and unique physico-chemical properties as well as varied industrial applications, and many of them are promptly becoming economically competitive. Scleroglucan, a beta-1,3-beta-1,6-glucan secreted by Sclerotium fungi, exhibits high potential for commercialization and may show different branching frequency, side-chain length and/or molecular weight depending on the producing strain or culture conditions. Water-solubility, viscosifying ability and wide stability over temperature, pH and salinity make scleroglucan useful for different biotechnological (enhanced oil recovery, food additives, drug delivery, cosmetic and pharmaceutical products, biocompatible materials, etc., and biomedical (immunoceutical, antitumor, etc. applications. It can be copiously produced at bioreactor scale under standardized conditions, where a high EPS concentration normally governs the process optimization. Operative and nutritional conditions, as well as the incidence of scleroglucan downstream processing will be discussed in this chapter. The relevance of using standardized inocula from selected strains and experiences concerning the intricate scleroglucan scaling-up will be also herein outlined.

  8. Downstream the hall EHN1

    CERN Multimedia


    Jura is towards left, Saleve towards right. Starting from left the photo shows the area behind NA5 (not shown) where later the EHS (European Hybrid Spectrometer) was installed; the neutron beam line N4 to NA6 (neutron elastic scattering at very small angle, by the Freiburg-Moscow (ITEP) Collaboration); the E4/H4 beam line to NA1 (Photoproduction of vector and scalar bosons by the Frascati-Milan-Pisa-Roma (FRAMM) Collaboration); the area of the H6 beam, behind NA3.

  9. A downstream voyage with mercury (United States)

    Heinz, Gary


    Retrospective essay for the Bulletin of Environmental Contamination and Toxicology.As I look back on my paper, “Effects of Low Dietary Levels of Methyl Mercury on Mallard Reproduction,” published in 1974 in the Bulletin of Environmental Contamination and Toxicology, a thought sticks in my mind. I realize just how much my mercury research was not unlike a leaf in a stream, carried this way and that, sometimes stalled in an eddy, restarted, and carried downstream at a pace and path that was not completely under my control. I was hired in 1969 by the Patuxent Wildlife Research Center to study the effects of environmental pollutants on the behavior of wildlife. A colleague was conducting a study on the reproductive effects of methylmercury on mallards (Anas platyrhynchos), and he offered to give me some of the ducklings. I conducted a pilot study, testing how readily ducklings approached a tape-recorded maternal call. Sample sizes were small, but the results suggested that ducklings from mercury-treated parents behaved differently than controls. That’s how I got into mercury research—pretty much by chance.

  10. IMAA (Integrated Measurements of Aerosol in Agri valley) campaign: Multi-instrumental observations at the largest European oil/gas pre-treatment plant area (United States)

    Calvello, Mariarosaria; Caggiano, Rosa; Esposito, Francesco; Lettino, Antonio; Sabia, Serena; Summa, Vito; Pavese, Giulia


    A short-term intensive multi-instrumental measurement campaign (Integrated Measurements of Aerosol in Agri valley - IMAA) was carried out near the largest European oil and gas pre-treatment plant (Centro Olio Val d'Agri - COVA) in a populated area, where, so far, ample characterization of aerosol loading is missing. As such, between the 2 and 17 July in 2013, using a number of instruments analyses were carried out on physical, chemical, morphological and optical properties of aerosol at this distinctive site, at both ground and over the atmospheric column, including the investigation of the mixing and transformation of particles. The observation of slag silicates with a rough surface texture is consistent with the presence of oil-related activities which represent the only industrial activity in the area. Desulfurization/sulfur liquefaction processes occurring at COVA can explain the peculiar morphology of calcium-sodium-aluminum particles. The common COVA source was associated with high concentrations of sulfur, nickel and zinc, and with significant correlations between zinc-sulfur and zinc-nickel. The Optical Particle Sizer (OPS) data, hygroscopicity and optical properties of atmospheric aerosol are consistent with the typical oil-derived gaseous emissions (e.g. sulfur dioxide and methane) that strongly influence the mixing state of particles and their size distributions. Continuous combustion processes at COVA were found to be responsible for Equivalent Black Carbon (EBC) concentrations from their relevant contribution to the total number of fine particles. The expected significant contribution of WS (water soluble) and BC (Black Carbon) components to the total Aerosol Optical Depth (AOD) are consistent with the results from the radiometric model especially for July 3 and 16.

  11. Assessing the effects of the Prestige oil spill on the European shag (Phalacrocorax aristotelis): Trace elements and stable isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Sanpera, Carola [Dept. Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona (Spain)], E-mail:; Valladares, Sonia; Moreno, Rocio; Ruiz, Xavier [Dept. Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Diagonal 645, 08028 Barcelona (Spain); Jover, Lluis [Dept. Salut Publica, Facultat de Medicina, Universitat de Barcelona, Casanova 143, 08036 Barcelona (Spain)


    The Prestige oil spill resulted in the mortality of several seabird species on the Atlantic NW coast of Spain. Shag casualties were particularly relevant, since populations are resident in the area the whole year round and because of several features which make them highly vulnerable to environmental hazards. Ecological catastrophes give us the opportunity of collecting samples which, otherwise, would be difficult to obtain. We examine the potential of shag corpses as bioindicators of inorganic pollution and the possible factors of variability, such as biological traits (sex, age) or nutrition status. We determined trace elements (Hg, Se, Cr, Pb, Zn and Cu) and isotopic signatures ({sup 15}N, {sup 13}C) in soft tissues (muscle, liver) and in primary feathers formed at different times (before and after the Prestige) in individuals of known sex and age, collected at the time of the Prestige disaster. These were compared with data from another group of shags trapped accidentally in fishing gear in 2005. Our results did not seem to be affected by sex or age on any of the analysed variables. The higher nitrogen isotopic signatures in the soft tissues of the Prestige shags may be related to the nutrition stress caused by a poorer body condition, which is also reflected in increasing levels of some metals in the liver. This isotopic enrichment was also observed in newly forming feathers when compared to the old ones. On the other hand, the lower {delta}{sup 15}N and Hg values in shag feathers from 2005 point to a shift in feeding resources to prey of lower trophic levels. We found that feather features (being an inert tissue and having a conservative composition), if combined with careful dating and chemical analysis, offer a very useful tool to evaluate temporal and spatial changes in seabird ecology in relation to pollution events.


    Directory of Open Access Journals (Sweden)

    V. M. Neuimin


    Full Text Available The author presents analysis of renovation variants for 300 MW oil-gas power blocks: substitution of the steam-power energy blocks by those with gas-steam cycle units, technical re-equipment of the energy blocks by means of reconstruction or modernization of the steam turbine, substitution implementation of the steam turbine with an analogous new one, prolongation of the operation life of the equipment in service. Renovation variants for the power blocks of the specified type in the TPPs of Russia can be chosen based on various engineering solutions concluded on the following grounds: mediumand long-term perspectives of their fuel balance structure (natural gas, synthetic gas fuel-oil residual, pulverized coal fuel including clean-coal and coal-benefication production wastes; the demands laid by JSC the JI UES on the participation of power blocks in frequency regulation and node inter-flow; development in the country of the distributed generation and the perspectives associated with it of the reconstructed TPPs installed capacity utilization in corresponding power-grid nodes; the development of related industries of the country’s economy; the speed of mastering the eco-friendly homegrown steam-gas and coal technologies; creation of the competitive national element base of microelectronics.Introduction of foreign steam-gas generators in this country requires development of the repair-and-service maintenance, provokes elevated risks and tangible costs, conduces to level decrease in the energy and national safety of the state. Orientation of the country’s power engineers to foreign gas-turbines of large single-unit capacity does not contribute to domestic power-plant industry development. With the view of reduction in value of the TPP-equipment by 12–15 %, it is prudent for power engineers to form a perspective manufacturing order for the period after 2016. In light of emerging political and economic situation in the world, technical re

  13. Mergers and acquisitions of downstream facilities by producing countries

    Energy Technology Data Exchange (ETDEWEB)

    Ligon, D.R.


    The author discusses a phenomenon that he calls the ''re-integration'' or ''re-coupling'' of the worldwide oil industry, as foreign, particularly OPEC, producers are becoming directly involved with downstream operations in their most important markets. This phenomenon already has produced some far-reaching consequences that will become even more important and pervasive in the near future. First, he describes the factors and logic that led to these arrangements. Next, he outlines some of their practical considerations and implications. While some of the market factors described are applicable to any non-integrated producer, he spends most of his time discussing OPEC and ''neo-OPEC'' producers such as Mexico. These are the people doing the deals and are therefore probably of greatest interest.

  14. Scleroglucan: Fermentative Production, Downstream Processing and Applications

    Directory of Open Access Journals (Sweden)

    Shrikant A. Survase


    Full Text Available Exopolysaccharides produced by a variety of microorganisms find multifarious industrial applications in foods, pharmaceutical and other industries as emulsifiers, stabilizers, binders, gelling agents, lubricants, and thickening agents. One such exopolysaccharide is scleroglucan, produced by pure culture fermentation from filamentous fungi of genus Sclerotium. The review discusses the properties, fermentative production, downstream processing and applications of scleroglucan.

  15. Downstream bioprocess characterisation within microfluidic devices

    DEFF Research Database (Denmark)

    Marques, Marco; Krühne, Ulrich; Szita, Nicolas


    Miniaturising bioprocess unit operation steps is a well-established approach to find novel routes for process intensification and improved process economics. While a number of microbioreactors have been presented over the last 15 years, miniaturised downstream unit operations (mDUO) are less...

  16. A European Open Science Cloud


    EIROforum IT working group; CERN IT Department


    This document outlines the position of EIROforum on a European Open Science Cloud. It explores the essential characteristics of a European Open Science Cloud if it is to address the big data needs of the latest generation of Research Infrastructures. The high‐level architecture and key services as well as the role of standards is described. A governance and financial model together with the roles of the stakeholders, including commercial service providers and downstream business sectors, that...

  17. DARHT-II Downstream Beam Transport Beamline

    Energy Technology Data Exchange (ETDEWEB)

    Westenskow, G A; Bertolini, L R; Duffy, P T; Paul, A C


    This paper describes the mechanical design of the downstream beam transport line for the second axis of the Dual Axis Radiographic Hydrodynamic Test (DARHT II) Facility. The DARHT-II project is a collaboration between LANL, LBNL and LLNL. DARHT II is a 20-MeV, 2000-Amperes, 2-{micro}sec linear induction accelerator designed to generate short bursts of x-rays for the purpose of radiographing dense objects. The downstream beam transport line is approximately 20-meter long region extending from the end of the accelerator to the bremsstrahlung target. Within this proposed transport line there are 15 conventional solenoid, quadrupole and dipole magnets; as well as several specialty magnets, which transport and focus the beam to the target and to the beam dumps. There are two high power beam dumps, which are designed to absorb 80-kJ per pulse during accelerator start-up and operation. Aspects of the mechanical design of these elements are presented.

  18. India's Downstream Petroleum Sector

    Energy Technology Data Exchange (ETDEWEB)



    This study provides a holistic examination of pricing and investment dynamics in India's downstream petroleum sector. It analyses the current pricing practices, highlights the tremendous fiscal cost of current pricing and regulatory arrangements, and examines the sectoral investment dynamics. It also looks at potential paths towards market-based reform along which the Indian government may move, while at the same time protecting energy market access for India's large poor population.

  19. DARHT-II Downstream Transport Beamline

    Energy Technology Data Exchange (ETDEWEB)

    Westenskow, G A; Bertolini, L R; Duffy, P T; Paul, A C


    This paper describes the mechanical design of the downstream beam transport line for the second axis of the Dual Axis Radiographic Hydrodynamic Test (DARHT II) Facility. The DARHT-II project is a collaboration between LANL, LBNL and LLNL. DARHT II is a 18.4-MeV, 2000-Amperes, 2-{micro}sec linear induction accelerator designed to generate short bursts of x-rays for the purpose of radiographing dense objects. The downstream beam transport line is approximately 22-meter long region extending from the end of the accelerator to the bremsstrahlung target. Within this proposed transport line there are 12 conventional solenoid, quadrupole and dipole magnets; as well as several specialty magnets, which transport and focus the beam to the target and to the beam dumps. There are two high power beam dumps, which are designed to absorb 80-kJ per pulse during accelerator start-up and operation. Aspects of the mechanical design of these elements are presented.

  20. Upstream and Downstream Influence in STBLI Instability (United States)

    Martin, Pino; Priebe, Stephan; Helm, Clara


    Priebe and Martín (JFM, 2012) show that the low-frequency unsteadiness in shockwave and turbulent boundary layer interactions (STBLI) is governed by an inviscid instability. Priebe, Tu, Martín and Rowley (JFM, 2016) show that the instability is an inviscid centrifugal one, i.e Görtlerlike vortices. Previous works had given differing conclusions as to whether the low-frequency unsteadiness in STBLI is caused by an upstream or downstream mechanism. In this paper, we reconcile these opposite views and show that upstream and downstream correlations co-exist in the context of the nature of Görtler vortices. We find that the instability is similar to that in separated subsonic and laminar flows. Since the turbulence is modulated but passive to the global mode, the turbulent separated flows are amenable to linear global analysis. As such, the characteristic length and time scales, and the receptivity of the global mode might be determined, and low-order models that represent the low-frequency dynamics in STBLI might be developed. The centrifugal instability persists even under hypersonic conditions. This work is funded by the AFOSR Grant Number AF9550-15-1-0284 with Dr. Ivett Leyva.

  1. Downstream Thermal Evolution of Vortex Cores (United States)

    Gómez-Barea, A.; Herrada, M. A.; Pérez-Saborid, M.; Barrero, A.


    The downstream evolution of the total temperature field in a quasi-incompressible axisymmetric vortex core has been computed. Starting at an initial station (z=0) with velocity profiles of the Burgers type and given temperature distributions, the numerical results of the evolution show that, according to experimental results, the total temperature in the near-axis region decreases substantially due to the work done by pressure and viscous forces together with the effect of both convection and conduction of heat. Depending on the values of the parameters characterizing the initial profiles and on the value of the Prandtl number, the vortex either breaks down or eventually reaches a self-similar regime. The results obtained shed light on the basic physics involved in the thermal separation phenomenon which appears inside Ranque-Hilsch vortex tubes.

  2. Downstream process options for the ABE fermentation. (United States)

    Friedl, Anton


    Butanol is a very interesting substance both for the chemical industry and as a biofuel. The classical distillation process for the removal of butanol is far too energy demanding, at a factor of 220% of the energy content of butanol. Alternative separation processes studied are hybrid processes of gas-stripping, liquid-liquid extraction and pervaporation with distillation and a novel adsorption/drying/desorption hybrid process. Compared with the energy content of butanol, the resulting energy demand for butanol separation and concentration of optimized hybrid processes is 11%-22% for pervaporation/distillation and 11%-17% for liquid-liquid extraction/distillation. For a novel adsorption/drying/desorption process, the energy demand is 9.4%. But all downstream process options need further proof of industrial applicability. © FEMS 2016. All rights reserved. For permissions, please e-mail:

  3. A guide to toxicity assessment and monitoring effects at lower levels of biological organization following marine oil spills in European waters

    NARCIS (Netherlands)

    Martínez-Gómez, C.; Vethaak, A.D.; Hylland, K.; Burgeot, T.; Köhler, A.; Lyons, B.P.; Thain, J.; Gubbins, M.J.; Davies, I.M.


    The usefulness of applying biological-effects techniques (bioassays and biomarkers) as tools to assist in evaluating damage to the health of marine ecosystems produced by oil spills has been demonstrated clearly during recent decades. Guidelines are provided for the use of biological-effects

  4. Ammonia downstream from HH 80 North (United States)

    Girart, Jose M.; Rodriguez, Luis F.; Anglada, Guillem; Estalella, Robert; Torrelles, Jose, M.; Marti, Josep; Pena, Miriam; Ayala, Sandra; Curiel, Salvador; Noriega-Crespo, Alberto


    HH 80-81 are two optically visible Herbig-Haro (HH) objects located about 5 minutes south of their exciting source IRAS 18162-2048. Displaced symmetrically to the north of this luminous IRAS source, a possible HH counterpart was recently detected as a radio continuum source with the very large array (VLA). This radio source, HH 80 North, has been proposed to be a member of the Herbig-Haro class since its centimeter flux density, angular size, spectral index, and morphology are all similar to those of HH 80. However, no object has been detected at optical wavelengths at the position of HH 80 North, possibly because of high extinction, and the confirmation of the radio continuum source as an HH object has not been possible. In the prototypical Herbig-Haro objects HH 1 and 2, ammonia emission has been detected downstream of the flow in both objects. This detection has been intepreted as a result of an enhancement in the ammonia emission produced by the radiation field of the shock associated with the HH object. In this Letter we report the detection of the (1,1) and (2,2) inversion transitions of ammonia downstream HH 80 North. This detection gives strong suppport to the interpretation of HH 80 North as a heavily obscured HH object. In addition, we suggest that ammonia emission may be a tracer of embedded Herbig-Haro objects in other regions of star formation. A 60 micrometer IRAS source could be associated with HH 80 North and with the ammonia condensation. A tentative explanation for the far-infrared emission as arising in dust heated by their optical and UV radiation of the HH object is presented.

  5. Behaviour and passage of European silver eels (Anguilla anguilla at a small hydropower plant during their downstream migration Comportement et passage de l’anguille argentée (Anguilla anguilla au niveau d’une petite centrale hydroélectrique lors de sa migration de dévalaison

    Directory of Open Access Journals (Sweden)

    De-Oliveira E.


    Full Text Available Between 2004 and 2007, 116 downstream migrant silver eels (Anguilla anguilla were monitored at a hydropower plant on the Gave de Pau river in South-West France using radio and PIT telemetry. The objectives of the study were: (i to determine the environmental conditions when eels arrived and passed the facility; (ii to determine the rate of eel escapement (passage other than via the turbines; (iii to describe the behaviour of eels faced with the intake structure and the permeability of the intake trashracks for the different sizes of eel; and (iv to determine whether surface bypasses originally designed for salmon could be effective for eels. Five types of behaviour of silver eels in the forebay and at the plant intakes were identified. The study showed the key factor influencing both eel behaviour and the route taken through the plant was variation in river discharge. Escapement rate was related to eel length and the spill flow to river flow ratio, which could be described by a logistic regression model. The surface bypasses originally designed for salmon were found to aid downstream eel migration significantly. At velocities < 0.40 m·s−1, no eels, even the largest, for which the racks are a physical barrier, were found impinged on the trashracks. De 2004 à 2007, une étude sur la migration de dévalaison de l’anguille argentée européenne (Anguilla anguilla a été menée sur la centrale hydroélectrique de Baigts sur le Gave de Pau dans le Sud-Ouest de la France. Cette étude, au cours de laquelle 116 individus ont été suivis par télémétrie PIT et radio, avait pour objectifs : (i de déterminer les conditions de milieu propices à l’arrivée sur site et au franchissement de l’aménagement; (ii de déterminer les taux d’échappement (passages par des voies autres que les turbines; (iii d’analyser le comportement des anguilles devant les ouvrages et la perméabilité des grilles de la prise d’eau en fonction de la taille

  6. Downstream Processing of Synechocystis for Biofuel Production (United States)

    Sheng, Jie

    Lipids and free fatty acids (FFA) from cyanobacterium Synechocystis can be used for biofuel (e.g. biodiesel or renewable diesel) production. In order to utilize and scale up this technique, downstream processes including culturing and harvest, cell disruption, and extraction were studied. Several solvents/solvent systems were screened for lipid extraction from Synechocystis. Chloroform + methanol-based Folch and Bligh & Dyer methods were proved to be "gold standard" for small-scale analysis due to their highest lipid recoveries that were confirmed by their penetration of the cell membranes, higher polarity, and stronger interaction with hydrogen bonds. Less toxic solvents, such as methanol and MTBE, or direct transesterification of biomass (without preextraction step) gave only slightly lower lipid-extraction yields and can be considered for large-scale application. Sustained exposure to high and low temperature extremes severely lowered the biomass and lipid productivity. Temperature stress also triggered changes of lipid quality such as the degree of unsaturation; thus, it affected the productivities and quality of Synechocystis-derived biofuel. Pulsed electric field (PEF) was evaluated for cell disruption prior to lipid extraction. A treatment intensity > 35 kWh/m3 caused significant damage to the plasma membrane, cell wall, and thylakoid membrane, and it even led to complete disruption of some cells into fragments. Treatment by PEF enhanced the potential for the low-toxicity solvent isopropanol to access lipid molecules during subsequent solvent extraction, leading to lower usage of isopropanol for the same extraction efficiency. Other cell-disruption methods also were tested. Distinct disruption effects to the cell envelope, plasma membrane, and thylakoid membranes were observed that were related to extraction efficiency. Microwave and ultrasound had significant enhancement of lipid extraction. Autoclaving, ultrasound, and French press caused significant

  7. Heavy oil markets and investments

    Energy Technology Data Exchange (ETDEWEB)

    Forrest, Jackie [CERA North America (United States)


    With the depletion of traditional energy resources and the rising demand for energy, the exploitation of heavy oil resources is increasing. The aim of this paper is to present the heavy oil sector and to show which are the factors influencing heavy oil growth and production. A large part of heavy oil reserves lies in the Americas, with about 45% of the world's reserves in Latin America and over 35% in North America. The development of the heavy oil sector is dependent on economic, technological and environmental factors; greenhouse gas policies have important impacts on the development of the heavy oil industry as well as downstream market access. This presentation highlighted the great potential that North and South America have in terms of heavy oil but that the development of this sector will depend on several factors.

  8. Microencapsulation, chemical characterization, and antimicrobial activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) oregano essential oils. (United States)

    Hernández-Hernández, Elvia; Regalado-González, Carlos; Vázquez-Landaverde, Pedro; Guerrero-Legarreta, Isabel; García-Almendárez, Blanca E


    The effect of solvent polarity (methanol and pentane) on the chemical composition of hydrodistilled essential oils (EO's) of Lippia graveolens H.B.K. (MXO) and Origanum vulgare L. (EUO) was studied by GC-MS. Composition of modified starch microencapsulated EO's was conducted by headspace-solid-phase microextraction (HS-SPME). The antimicrobial activity of free and microencapsulated EO's was evaluated. They were tested against Salmonella sp., Brochothrix thermosphacta, Pseudomonas fragi, Lactobacillus plantarum, and Micrococcus luteus. Thymol and carvacrol were among the main components of EO's and their free and microencapsulated inhibitory activity was tested against M. luteus, showing an additive combined effect. Chemical composition of EO's varied according to the solvent used for GC analysis and to volatile fraction as evaluated by HS-SPME. Thymol (both solvents) was the main component in essential oil of MXO, while carvacrol was the main component of the volatile fraction. EUO showed α-pinene (methanol) and γ-terpinene (pentane) as major constituents, the latter being the main component of the volatile fraction. EO's showed good stability after 3 months storage at 4°C, where antimicrobial activity of microencapsulated EO's remained the same, while free EO's decreased 41% (MXO) and 67% (EUO) from initial activity. Microencapsulation retains most antimicrobial activity and improves stability of EO's from oregano.

  9. Microencapsulation, Chemical Characterization, and Antimicrobial Activity of Mexican (Lippia graveolens H.B.K. and European (Origanum vulgare L. Oregano Essential Oils

    Directory of Open Access Journals (Sweden)

    Elvia Hernández-Hernández


    Full Text Available The effect of solvent polarity (methanol and pentane on the chemical composition of hydrodistilled essential oils (EO’s of Lippia graveolens H.B.K. (MXO and Origanum vulgare L. (EUO was studied by GC-MS. Composition of modified starch microencapsulated EO’s was conducted by headspace-solid-phase microextraction (HS-SPME. The antimicrobial activity of free and microencapsulated EO’s was evaluated. They were tested against Salmonella sp., Brochothrix thermosphacta, Pseudomonas fragi, Lactobacillus plantarum, and Micrococcus luteus. Thymol and carvacrol were among the main components of EO’s and their free and microencapsulated inhibitory activity was tested against M. luteus, showing an additive combined effect. Chemical composition of EO’s varied according to the solvent used for GC analysis and to volatile fraction as evaluated by HS-SPME. Thymol (both solvents was the main component in essential oil of MXO, while carvacrol was the main component of the volatile fraction. EUO showed α-pinene (methanol and γ-terpinene (pentane as major constituents, the latter being the main component of the volatile fraction. EO’s showed good stability after 3 months storage at 4°C, where antimicrobial activity of microencapsulated EO’s remained the same, while free EO’s decreased 41% (MXO and 67% (EUO from initial activity. Microencapsulation retains most antimicrobial activity and improves stability of EO’s from oregano.

  10. Microencapsulation, Chemical Characterization, and Antimicrobial Activity of Mexican (Lippia graveolens H.B.K.) and European (Origanum vulgare L.) Oregano Essential Oils (United States)

    Regalado-González, Carlos; Vázquez-Landaverde, Pedro; Guerrero-Legarreta, Isabel; García-Almendárez, Blanca E.


    The effect of solvent polarity (methanol and pentane) on the chemical composition of hydrodistilled essential oils (EO's) of Lippia graveolens H.B.K. (MXO) and Origanum vulgare L. (EUO) was studied by GC-MS. Composition of modified starch microencapsulated EO's was conducted by headspace-solid-phase microextraction (HS-SPME). The antimicrobial activity of free and microencapsulated EO's was evaluated. They were tested against Salmonella sp., Brochothrix thermosphacta, Pseudomonas fragi, Lactobacillus plantarum, and Micrococcus luteus. Thymol and carvacrol were among the main components of EO's and their free and microencapsulated inhibitory activity was tested against M. luteus, showing an additive combined effect. Chemical composition of EO's varied according to the solvent used for GC analysis and to volatile fraction as evaluated by HS-SPME. Thymol (both solvents) was the main component in essential oil of MXO, while carvacrol was the main component of the volatile fraction. EUO showed α-pinene (methanol) and γ-terpinene (pentane) as major constituents, the latter being the main component of the volatile fraction. EO's showed good stability after 3 months storage at 4°C, where antimicrobial activity of microencapsulated EO's remained the same, while free EO's decreased 41% (MXO) and 67% (EUO) from initial activity. Microencapsulation retains most antimicrobial activity and improves stability of EO's from oregano. PMID:25177730

  11. A floating trap for sampling downstream migrant fishes. (United States)

    Carl E. McLemore; Fred H. Everest; William R. Humphreys; Mario F. Solazzi


    Fishery scientists and managers are interested in obtaining information about downstream movements of fish species for biological and economic reasons. Different types of nets and traps have been used for this purpose with only partial success. The floating, self-cleaning downstream migrant trap described here proved successful for sampling several salmoniform and...

  12. European communion

    DEFF Research Database (Denmark)

    Manners, Ian James


    Political theory of European union, through an engagement between political concepts and theoretical understandings, provides a means of identifying the EU as a political object. It is argued that understanding the projects, processes and products of European union, based on ‘sharing’ or ‘communion......’, provides a better means of perceiving the EU as a political object rather than terms such as ‘integration’ or ‘co-operation’. The concept of ‘European communion’ is defined as the ‘subjective sharing of relationships’, understood as the extent to which individuals or groups believe themselves to be sharing...... relations (or not), and the consequences of these beliefs for European political projects, processes and products. By exploring European communion through an engagement with contemporary political theory, using very brief illustrations from the Treaty of Lisbon, the article also suggests that European...

  13. Palm Oil (United States)

    Palm oil is obtained from the fruit of the oil palm tree. Palm oil is used for preventing vitamin A deficiency, cancer, ... high blood pressure, high cholesterol, and cyanide poisoning. Palm oil is used for weight loss and increasing the ...

  14. Diesel oil (United States)

    Oil ... Diesel oil ... Diesel oil poisoning can cause symptoms in many parts of the body. EYES, EARS, NOSE, AND THROAT Loss of ... most dangerous effects of hydrocarbon (such as diesel oil) poisoning are due to inhaling the fumes. NERVOUS ...

  15. Oil Spills (United States)

    ... approach evaluating oil spill conditions. You are here Home | Oil and Chemical Spills | Oil Spills On Our Radar ... US Department of Commerce | Main menu Home Oil and Chemical Spills Environmental Restoration Marine Debris Training ...

  16. European Institutions?

    NARCIS (Netherlands)

    Meacham, Darian


    The aim of this article is to sketch a phenomenological theory of political institutions and to apply it to some objections and questions raised by Pierre Manent about the project of the European Union and more specifically the question of “European Construction”, i.e. what is the aim of the

  17. Selective Europeanization

    DEFF Research Database (Denmark)

    Hoch Jovanovic, Tamara; Lynggaard, Kennet


    political contexts at the European level. We further show how the “translation” of international norms to a domestic context has worked to reinforce the original institutional setup, dating back to the mid-1950s. The translation of European-level minority policy developed in the 1990s and 2000s works most...

  18. Drowning in muddied waters or swimming downstream? A critical ...

    African Journals Online (AJOL)

    Drowning in muddied waters or swimming downstream? A critical analysis of literature reviewing in a phenomenological study through an exploration of the lifeworld, reflexivity and role of the researcher.

  19. Upstream trophic structure modulates downstream community dynamics via resource subsidies. (United States)

    Harvey, Eric; Gounand, Isabelle; Little, Chelsea J; Fronhofer, Emanuel A; Altermatt, Florian


    In many natural systems, the physical structure of the landscape dictates the flow of resources. Despite mounting evidence that communities' dynamics can be indirectly coupled by reciprocal among ecosystem resource flows, our understanding of how directional resource flows might indirectly link biological communities is limited. We here propose that differences in community structure upstream should lead to different downstream dynamics, even in the absence of dispersal of organisms. We report an experimental test of the effect of upstream community structure on downstream community dynamics in a simplified but highly controlled setting, using protist microcosms. We implemented directional flows of resources, without dispersal, from a standard resource pool into upstream communities of contrasting interaction structure and then to further downstream communities of either one or two trophic levels. Our results demonstrate that different types of species interactions in upstream habitats may lead to different population sizes and levels of biomass in these upstream habitats. This, in turn, leads to varying levels of detritus transfer (dead biomass) to the downstream communities, thus influencing their population densities and trophic interactions in predictable ways. Our results suggest that the structure of species interactions in directionally structured ecosystems can be a key mediator of alterations to downstream habitats. Alterations to upstream habitats can thus cascade down to downstream communities, even without dispersal.

  20. Downstream-based Scheduling for Energy Conservation in Green EPONs

    KAUST Repository

    Chen, Shen


    Maximizing the optical network unit’s (ONU) sleep time is an effective approach for achieving maximum energy conservation in green Ethernet passive optical networks (EPONs). While overlapping downstream and upstream ONU transmissions can maximize the ONU sleep time, it jeopardizes the quality of service (QoS) performance of the network, especially for downstream traffic in case the overlapping is based on the upstream time slot. In this paper, we study the downstream traffic performance in green EPONs under the limited service discipline and the upstream-based overlapped time window. Specifically, we first derive the expected mean packet delay, and then present a closed-form expression of the ONU sleep time, setting identical upstream/downstream transmission cycle times based on a maximum downstream traffic delay re-quirement. With the proposed system model, we present a novel downstream bandwidth allocation scheme for energy conservation in green EPONs. Simulation results verify the proposed model and highlight the advantages of our scheme over conventional approaches.

  1. European Whiteness?

    DEFF Research Database (Denmark)

    Blaagaard, Bolette


    Born out of the United States’ (U.S.) history of slavery and segregation and intertwined with gender studies and feminism, the field of critical whiteness studies does not fit easily into a European setting and the particular historical context that entails. In order for a field of European...... critical whiteness studies to emerge, its relation to the U.S. theoretical framework, as well as the particularities of the European context need to be taken into account.. The article makes a call for a multi-layered approach to take over from the identity politics so often employed in the fields of U...

  2. European Security

    DEFF Research Database (Denmark)

    Møller, Bjørn

    Theoretical chapters on "Security", "Organisations" and "Regions," Historical Chapters on "Europe and Its Distinguishing Features" and on "The United Nations," "NATO," "The CSCE/OSCE and the Council of Europe" and "The European Union"......Theoretical chapters on "Security", "Organisations" and "Regions," Historical Chapters on "Europe and Its Distinguishing Features" and on "The United Nations," "NATO," "The CSCE/OSCE and the Council of Europe" and "The European Union"...

  3. Sequence variations in C9orf72 downstream of the hexanucleotide repeat region and its effect on repeat-primed PCR interpretation

    DEFF Research Database (Denmark)

    Nordin, Angelica; Akimoto, Chizuru; Wuolikainen, Anna


    A large GGGGCC-repeat expansion mutation (HREM) in C9orf72 is the most common known cause of ALS and FTD in European populations. Sequence variations immediately downstream of the HREM region have previously been observed and have been suggested to be one reason for difficulties in interpreting RP...

  4. Analysis of palm oil industry cluster in Jambi Province


    Erfit Erfit


    This study aims to analyze palm oil industry clusters in Jambi Province. This study is a collective case study (survey and case study). The result shows that Jambi Province has a considerable potential for the development of palm oil industry. It can be seen from the development of plantation area, production of Palm Fresh Fruit Bunches, Crude Palm Oil, Palm Kernel Oil, and Palm Oil Mill. However, there are still very limited downstream products of palm oil that can be produced. Based on SWOT...

  5. European visit

    CERN Multimedia


    The European Commissioner for Science and Research, Janez Potočnik, (on the right) visited the CMS assembly hall accompanied by Jim Virdee, Deputy Spokesman of CMS (on the left), and Robert Aymar, Director-General of CERN. The European Commissioner for Science and Research, Janez Potočnik, visited CERN on Tuesday 31 January. He was welcomed by the Director-General, Robert Aymar, who described the missions and current activities of CERN to him, in particular the realisation of the LHC with its three components: accelerator, detectors, storage and processing of data. The European Commissioner then visited the CMS assembly hall, then the hall for testing the LHC magnets and the ATLAS cavern. During this first visit since his appointment at the end of 2004, Janez Potočnik appeared very interested by the operation of CERN, an example of successful scientific co-operation on a European scale. The many projects (30 on average) that CERN and the European Commission carry out jointly for the benefit of res...

  6. Oil Spills (United States)

    Oil spills often happen because of accidents, when people make mistakes or equipment breaks down. Other causes include natural disasters or deliberate acts. Oil spills have major environmental and economic effects. Oil ...

  7. Coconut Oil (United States)

    ... it by mouth to lose weight and lower cholesterol. Coconut oil is sometimes applied to the skin as a ... coconut oil by mouth as a medicine. High cholesterol: Coconut oil contains a type of fat that can increase ...

  8. Ion energy characteristics downstream of a high power helicon

    Energy Technology Data Exchange (ETDEWEB)

    Prager, James; Winglee, Robert; Ziemba, Tim; Roberson, B Race; Quetin, Gregory [University of Washington, Johnson Hall 070, Box 351310, 4000 15th Avenue NE, Seattle, WA 98195-1310 (United States)], E-mail:


    The High Power Helicon eXperiment operates at higher powers (37 kW) and lower background neutral pressure than other helicon experiments. The ion velocity distribution function (IVDF) has been measured at multiple locations downstream of the helicon source and a mach 3-6 flowing plasma was observed. The helicon antenna has a direct effect in accelerating the plasma downstream of the source. Also, the IVDF is affected by the cloud of neutrals from the initial gas puff, which keeps the plasma speed low at early times near the source.

  9. Deregulation And Appropriate Pricing In The Downstream Sector Of ...

    African Journals Online (AJOL)

    This work x-rays the pricing of petroleum products in the Nigeria economy. From its findings it is able to establish that the petroleum product pricing has been very eccentric and at variance with what obtains in other countries of the world (both oil producing and non-oil producing). It calls on the government to tread warily, ...

  10. European Cinema

    NARCIS (Netherlands)

    Elsaesser, Thomas


    In the face of renewed competition from Hollywood since the early 1980s and the challenges posed to Europe's national cinemas by the fall of the Wall in 1989, independent filmmaking in Europe has begun to re-invent itself. European Cinema: Face to Face with Hollywood re-assesses the different

  11. The role of wing kinematics of freely flying birds downstream the wake of flapping wings (United States)

    Krishnan, Krishnamoorthy; Gurka, Roi


    Avian aerodynamics has been a topic of research for centuries. Avian flight features such as flapping, morphing and maneuvering make bird aerodynamics a complex system to study, analyze and understand. Aerodynamic performance of the flapping wings can be quantified by measuring the vortex structures present in the downstream wake. Still, the direct correlation between the flapping wing kinematics and the evolution of wake features need to be established. In this present study, near wake of three bird species (western sandpiper, European starling and American robin) have been measured experimentally. Long duration, time-resolved, particle image velocimetry technique has been used to capture the wake properties. Simultaneously, the bird kinematics have been captured using high speed camera. Wake structures are reconstructed from the collected PIV images for long chord distances downstream. Wake vorticities and circulation are expressed in the wake composites. Comparison of the wake features of the three birds shows similarities and some key differences are also found. Wing tip motions of the birds are extracted for four continuous wing beat cycle to analyze the wing kinematics. Kinematic parameters of all the three birds are compared to each other and similar trends exhibited by all the birds have been observed. A correlation between the wake evolutions with the wing motion is presented. It was found that the wings' motion generates unique flow patterns at the near wake, especially at the transition phases. At these locations, a drastic change in the circulation was observed.

  12. The Nigerian petroleum downstream sector and product pricing ...

    African Journals Online (AJOL)

    This research has been designed to explore critically the history of the downstream petroleum sector and the trend of pricing of Nigeria's petroleum products - looking closely at the contentious issue of subsidy and formulate a statistical model for the appropriate pricing of locally produced petroleum products.

  13. Downstream flow top width prediction in a river system | Choudhury ...

    African Journals Online (AJOL)

    ANFIS, ARIMA and Hybrid Multiple Inflows Muskingum models (HMIM) were applied to simulate and forecast downstream discharge and flow top widths in a river system. The ANFIS model works on a set of linguistic rules while the ARIMA model uses a set of past values to predict the next value in a time series. The HMIM ...

  14. Imaging for monitoring downstream processing of fermentation broths

    DEFF Research Database (Denmark)

    Moiseyenko, Rayisa; Baum, Andreas; Jørgensen, Thomas Martini

    In relation to downstream processing of a fermentation broth coagulation/flocculation is a typical pretreatment method for separating undesirable particles/impurities from the wanted product. In the coagulation process the negatively charged impurities are destabilized by adding of a clarifying...

  15. Downstream and upstream extension of the House of Quality

    DEFF Research Database (Denmark)

    Holmen, Elsebeth; Kristensen, Preben Sander

    a discussion in a diabetics end-user focus group. During a series of meetings, the production manager and the sales manager transformed attributes int characteristics and constructed Houses of Quality for a sugar-free cookie. 2. Downstream on its way to the end-user, the product passes through a chain of users...

  16. Downstream processing of Isochrysis galbana: a step towards microalgal biorefinery

    NARCIS (Netherlands)

    Gilbert-López, B.; Mendiola, J.A.; Fontecha, J.; Broek, van den L.A.M.; Sijtsma, L.; Cifuentes, A.; Herrero, M.; Ibáñez, E.


    An algae-based biorefinery relies on the efficient use of algae biomass through its fractionation of several valuable/bioactive compounds that can be used in industry. If this biorefinery includes green platforms as downstream processing technologies able to fulfill the requirements of green

  17. Doublesex: a conserved downstream gene controlled by diverse ...

    Indian Academy of Sciences (India)


    Sep 6, 2010 ... The Drosophila doublesex (dsx) gene at the bottom of the sex-determination cascade is the best charac- terized candidate so far, and is .... down of tra-2 in these insects results in complete reversal of genotypically female .... tributing the antagonistic effect of sex-specific Dsx proteins on their downstream ...

  18. Extreme wave phenomena in down-stream running modulated waves

    NARCIS (Netherlands)

    Andonowati, A.; Karjanto, N.; van Groesen, Embrecht W.C.

    Modulational, Benjamin-Feir, instability is studied for the down-stream evolution of surface gravity waves. An explicit solution, the soliton on finite background, of the NLS equation in physical space is used to study various phenomena in detail. It is shown that for sufficiently long modulation

  19. Oil Spill! (United States)

    Ansberry, Karen Rohrich; Morgan, Emily


    An oil spill occurs somewhere in the world almost every day of the year, and the consequences can be devastating. In this month's column, students explore the effects of oil spills on plants, animals, and the environment and investigate oil spill clean-up methods through a simulated oil spill. The activities described in this article give students…

  20. Oil risk in oil stocks

    NARCIS (Netherlands)

    Scholtens, Bert; Wang, L


    We assess the oil price sensitivities and oil risk premiums of NYSE listed oil & gas firms' returns by using a two-step regression analysis under two different arbitrage pricing models. Thus, we apply the Fama and French (1992) factor returns in a study of oil stocks. In all, we find that the return

  1. 'Patents and Downstream Innovation Suppression - Fact or Fiction?'

    DEFF Research Database (Denmark)

    Howells, John

    of that empirical evidence. They present alleged historical examples of downstream innovation suppression in such important technologies as: Edison's carbon filament light bulb; the automobile; radio; aircraft; the transistor; the computer. This paper presents a contrary interpretation of the role of patents......Merges and Nelson have provided an empirically grounded argument that firms use pioneer patents of 'broad' scope to block downstream technological development (Merges and Nelson 1990). If this is a regular occurrence then, as they claim, they have faulted Kitch's 'prospect theory' of patents (Kitch...... in any of the examples. I therefore draw the strong conclusion that their general thesis is unsupported by their selection of empirical evidence. The article then argues that although a subset of their cases illustrates patents acting to hinder developers (but not development of the relevant technology...

  2. Minimizing downstream scour due to submerged hydraulic jump using corrugated

    Directory of Open Access Journals (Sweden)

    Hossam Mohamed Ali


    Full Text Available Local scour downstream of hydraulic structures due to hydraulic jump is considered one of the tedious and complicated problems facing their stability. Throughout this paper, an experimental study was conducted to study the effect of using different spaced corrugated aprons on the downstream local scour due to submerged jump. Sixty runs were carried out in a horizontal rectangular flume to determine the optimal corrugation wavelength which minimizing the scour. A case of flat apron included to estimate the influence of corrugated aprons on scour holes dimensions. Two types of non-cohesive soil were used. Experiments were performed for a range of Froude numbers between 1.68 and 9.29. The results showed that using spaced triangular corrugated aprons minimize the scour depth and length of fine sand by average percentage of 63.4% and 30.2%, respectively and for coarse sand by 44.2% and 20.6% in comparing with classical jump.

  3. Patents and Downstream Innovation Suppression - Facts or Fiction?

    DEFF Research Database (Denmark)

    Howells, John

    Merges and Nelson have proposed that pioneer patents have enabled their owners to 'block' or 'hold-up' downstream innovation in cases as important as the car, radio, aircraft and electric lighting (Merges and Nelson 1990, ; Merges and Nelson 1994). Merges and Nelson use their work to question...... the value of Kitch's prospect theory of patents, a theory that the social value of patents is that they enable the efficient coordination of technological development.    I re-examine history and legal sources bearing on Merges and Nelson's illustrative cases and find no case to illustrate downstream...... innovation suppression as claimed.  I argue instead that these cases illustrate problems in the coordination of development caused by various faults in the administration of patents by US Congress, the US Patent Office or the courts....

  4. Dead zone area at the downstream flow of barrages

    Directory of Open Access Journals (Sweden)

    Mohamed F. Sauida


    Full Text Available Flow separation is a natural phenomenon encountered at some cases downstream of barrages. The main flow is divided into current and dead zone flows. The percentage area of dead zone flow must be taken into consideration downstream of barrages, due to its negative effect on flow characteristics. Experimental studies were conducted in the Hydraulic Research Institute (HRI, on a physical regulator model with five vents. Theoretically the separation zone is described as a part of an ellipse which is practically verified by plotting velocity vectors. The results show that the percentage area of dead zone to the area through length of separation depends mainly on the expansion ratio [channel width to width of opened vents], with maximum value of 81% for operated side gates. A statistical analysis was derived, to predict the percentage area of dead zone flow to the area through length of separation.

  5. European Energy Security amid Ukrainian Crisis

    Directory of Open Access Journals (Sweden)

    Kumar Vijay


    Full Text Available On the basis of overall analysis of the European dependence on Russia for its energy needs (mainly gas and oil this paper tries to argue that economic sanction against Russia will have limited success. It will hurt the region badly, but it has more potential to jeopardize the European energy security aspect – a long cherished goal of the European nations. So, the best means to solve the Ukraine crisis is political and diplomatic tools, not the economic ones.

  6. Peanut Oil (United States)

    Peanut oil is high in monounsaturated “good” fat, and low in saturated “bad” fat, which is believed to help prevent heart disease and lower cholesterol. However, in animal studies, peanut oil has been shown to ...

  7. Oil spills

    National Research Council Canada - National Science Library

    Moghissi, A.A


    Contents: Oil spills on land as potential sources of groundwater contamination / J.J. Duffy, E. Peake and M.F. Mohtadi -- Ecological effects of experimental oil spills in eastern coastal plain estuaries...

  8. Medium-Term Oil Market Report 2006

    Energy Technology Data Exchange (ETDEWEB)



    How much oil will the world consume in 2011? What role will OPEC play in global oil production? Will biofuels become an important part of the oil market? The International Energy Agencys (IEA) Medium-Term Oil Market Report tackles these questions, adopting a perspective that goes beyond the traditional short-term market analysis provided in the IEAs monthly Oil Market Report. Drawing on current futures curves and the investment threshold for upstream projects, the Medium-Term Oil Market Report analyses how global demand and supply balances may develop in the next five years. The forecasts look in detail at product demand and the supply potential from all the firmly planned individual upstream and downstream projects around the world. The results provide invaluable insights on vital issues such as surplus production capacity and product supply. The rapid pace of change in the oil market means that forecasts can become outdated very quickly. This interim update provides the opportunity to rebase the data and forecasts in the annual Medium-Term Oil Market Report and to discuss and analyse new issues affecting the oil industry. Policymakers, market analysts, energy experts and anyone interested in understanding and following trends in the oil market should find this report extremely useful.

  9. Oil Shale (United States)

    Birdwell, Justin E.


    Oil shales are fine-grained sedimentary rocks formed in many different depositional environments (terrestrial, lacustrine, marine) containing large quantities of thermally immature organic matter in the forms of kerogen and bitumen. If defined from an economic standpoint, a rock containing a sufficient concentration of oil-prone kerogen to generate economic quantities of synthetic crude oil upon heating to high temperatures (350–600 °C) in the absence of oxygen (pyrolysis) can be considered an oil shale.

  10. Mineral oils (United States)

    Furby, N. W.


    The characteristics of lubricants made from mineral oils are discussed. Types and compositions of base stocks are reviewed and the product demands and compositions of typical products are outlined. Processes for commercial production of mineral oils are examined. Tables of data are included to show examples of product types and requirements. A chemical analysis of three types of mineral oils is reported.

  11. Oil biodegradation

    NARCIS (Netherlands)

    Rahsepar, Shokouhalsadat; Langenhoff, Alette A.M.; Smit, Martijn P.J.; Eenennaam, van Justine S.; Murk, Tinka; Rijnaarts, Huub H.M.


    During the Deepwater Horizon (DwH) oil spill, interactions between oil, clay particles and marine snow lead to the formation of aggregates. Interactions between these components play an important, but yet not well understood, role in biodegradation of oil in the ocean water. The aim of this study

  12. Commissioning The Darht-II Accelerator Downstream Transport And Target

    Energy Technology Data Exchange (ETDEWEB)

    Ekdahl, Carl [Los Alamos National Laboratory; Schulze, Martin E [Los Alamos National Laboratory


    The DARHT-II accelerator produces a 2-kA, 17-MeV beam in a 1600-ns pulse. After exiting the accelerator, the pulse is sliced into four short pulses by a kicker and quadrupole septum and then transported for several meters to a tantalum target for conversion to x-rays for radiography. They describe the commissioning of the kicker, septum, transport, and multi-pulse converter target. The results of beam measurements made during the commissioning of the downstream transport are described.

  13. Downstream System for the Second Axis of the DARHT Facility

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Y-J; Bertolini, L; Caporaso, G J; Chambers, F W; Cook, E G; Falabella, S; Goldin, F J; Guethlein, G; Ho, D D-M; McCarrick, J F; Nelson, S D; Neurath, R; Paul, A C; Pincosy, P A; Poole, B R; Richardson, R A; Sampayan, S; Wang, L-F; Watson, J A; Westenskow, G A; Weir, J T


    This paper presents the physics design of the DARHT-II downstream system, which consists of a diagnostic beam stop, a fast, high-precision kicker system and the x-ray converter target assembly. The beamline configuration, the transverse resistive wall instability and the ion hose instability modeling are presented. They also discuss elimination of spot size dilution during kicker switching and implementation of the foil-barrier scheme to minimize the backstreaming ion focusing effects. Finally, they present the target converter's configuration, and the simulated DARHT-II x-ray spot sizes and doses. Some experimental results, which support the physics design, are also presented.

  14. Flame holding downstream from a co-flow injector (United States)

    Nicoli, Colette; Haldenwang, Pierre; Denet, Bruno


    We present numerical results on the flame attachment in the downstream vicinity of the co-flow injector lip that separates the reactive fluids at injection. Two stability diagrams show the domains where the flame is anchored, blown off, or extinguished, in terms of separating plate thickness and injection velocities of both fluids. Different anchoring modes—stagnation point counter-flow holding or edge flame anchorage—are described, depending particularly on the plate rim thickness. To cite this article: C. Nicoli et al., C. R. Mecanique 334 (2006).

  15. Recent Molecular Advances on Downstream Plant Responses to Abiotic Stress

    Directory of Open Access Journals (Sweden)

    Cláudia Regina Batista de Souza


    Full Text Available Abiotic stresses such as extremes of temperature and pH, high salinity and drought, comprise some of the major factors causing extensive losses to crop production worldwide. Understanding how plants respond and adapt at cellular and molecular levels to continuous environmental changes is a pre-requisite for the generation of resistant or tolerant plants to abiotic stresses. In this review we aimed to present the recent advances on mechanisms of downstream plant responses to abiotic stresses and the use of stress-related genes in the development of genetically engineered crops.

  16. The Legality Of Deregulating The Downstream Sector Of The ...

    African Journals Online (AJOL)

    This work appraises the legality of the recent deregulation of the down stream sector of te oil industry in light of the Mineral Act of 1990 and the Petroleum Products Pricing Regulation Agency (Establishment) Act 3. It appraises the general and specific principle of statutory interpretation, to see if there is a conflict between ...

  17. Natural Origin Lycopene and Its "Green" Downstream Processing. (United States)

    Papaioannou, Emmanouil H; Liakopoulou-Kyriakides, Maria; Karabelas, Anastasios J


    Lycopene is an abundant natural carotenoid pigment with several biological functions (well-known for its antioxidant properties) which is under intensive investigation in recent years. Lycopene chemistry, its natural distribution, bioavailability, biological significance, and toxicological effects are briefly outlined in the first part of this review. The second, major part, deals with various modern downstream processing techniques, which are assessed in order to identify promising approaches for the recovery of lycopene and of similar lipophilic compounds. Natural lycopene is synthesized in plants and by microorganisms, with main representatives of these two categories (for industrial production) tomato and its by-products and the fungus Blakeslea trispora, respectively. Currently, there is a great deal of effort to develop efficient downstream processing for large scale production of natural-origin lycopene, with trends strongly indicating the necessity for "green" and mild extraction conditions. In this review, emphasis is placed on final product safety and ecofriendly processing, which are expected to totally dominate in the field of natural-origin lycopene extraction and purification.

  18. Ferric chloride based downstream process for microalgae based biodiesel production. (United States)

    Seo, Yeong Hwan; Sung, Mina; Kim, Bohwa; Oh, You-Kwan; Kim, Dong Yeon; Han, Jong-In


    In this study, ferric chloride (FeCl3) was used to integrate downstream processes (harvesting, lipid extraction, and esterification). At concentration of 200 mg/L and at pH 3, FeCl3 exhibited an expected degree of coagulation and an increase in cell density of ten times (170 mg/10 mL). An iron-mediated oxidation reaction, Fenton-like reaction, was used to extract lipid from the harvested biomass, and efficiency of 80% was obtained with 0.5% H2O2 at 90 °C. The iron compound was also employed in the esterification step, and converted free fatty acids to fatty acid methyl esters under acidic conditions; thus, the fatal problem of saponification during esterification with alkaline catalysts was avoided, and esterification efficiency over 90% was obtained. This study clearly showed that FeCl3 in the harvesting process is beneficial in all downstream steps and have a potential to greatly reduce the production cost of microalgae-originated biodiesel. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Ion Effects in the DARHT-II Downstream Transport

    CERN Document Server

    Chan, Kwok-Chi D; Ekdahl, Carl; Genoni, Thomas C; Hughes, Thomas P; Schulze, Martin E


    The DARHT-II accelerator produces an 18-MeV, 2-kA, 2-μs electron beam pulse. After the accelerator, the pulse is delivered to the final focus on an x-ray producing target via a beam transport section called the Downstream Transport. Ions produced due to beam ionization of residual gases in the Downstream Transport can affect the beam dynamics. Ions generated by the head of the pulse will cause modification of space-charge forces at the tail of the pulse so that the beam head and tail will have different beam envelopes. They may also induce ion-hose instability at the tail of the pulse. If these effects are significant, the focusing requirements of beam head and tail at the final focus will become very different. The focusing of the complete beam pulse will be time dependent and difficult to achieve, leading to less efficient x-ray production. In this paper, we will describe the results of our calculations of these ion effects at different residual-gas pressure levels. Our goal is to determine the ma...

  20. Investigation on local scour downstream of adverse st

    Directory of Open Access Journals (Sweden)

    Javad Farhoudi


    Full Text Available This paper is focused on local scour downstream of adverse stilling basins where a submerged wall jet issued from a sluice gate. Experiments were conducted in a wide range of Froude numbers, grain sizes, tailwater depths, and stilling basin slopes. The results showed that the scour profiles at any bed slope follow shape similarity. However, the longitude evolution of scour profiles and the volume of eroded materials were increasing in accordance with slope of basin. A polynomial equation was derived to define the non-dimensional profiles under different slopes. The time evolution of scour hole dimensions and the equilibrium state were defined. It was found that under a specific condition of sediment grain size, approaching Froude number, the length and slope of adverse basin, the scour depth at the downstream of adverse basin, initially increases with tailwater depth, and after reaching its maximum value decreases to a constant value. It was also observed that the maximum depth of scour hole was decreased as the length and slope of stilling basin increased, whereas the longitudinal dimensions of the hole were increased. It was found that the maximum depth of scour hole occurs at the vicinity of side walls with slight decrease in the centerline. Finally, a power equation was expressed to fully define the dimensions of scour hole, time scale and geometry of sluice gate.

  1. Evaluation of Intracellular Signaling Downstream Chimeric Antigen Receptors.

    Directory of Open Access Journals (Sweden)

    Hannah Karlsson

    Full Text Available CD19-targeting CAR T cells have shown potency in clinical trials targeting B cell leukemia. Although mainly second generation (2G CARs carrying CD28 or 4-1BB have been investigated in patients, preclinical studies suggest that third generation (3G CARs with both CD28 and 4-1BB have enhanced capacity. However, little is known about the intracellular signaling pathways downstream of CARs. In the present work, we have analyzed the signaling capacity post antigen stimulation in both 2G and 3G CARs. 3G CAR T cells expanded better than 2G CAR T cells upon repeated stimulation with IL-2 and autologous B cells. An antigen-driven accumulation of CAR+ cells was evident post antigen stimulation. The cytotoxicity of both 2G and 3G CAR T cells was maintained by repeated stimulation. The phosphorylation status of intracellular signaling proteins post antigen stimulation showed that 3G CAR T cells had a higher activation status than 2G. Several proteins involved in signaling downstream the TCR were activated, as were proteins involved in the cell cycle, cell adhesion and exocytosis. In conclusion, 3G CAR T cells had a higher degree of intracellular signaling activity than 2G CARs which may explain the increased proliferative capacity seen in 3G CAR T cells. The study also indicates that there may be other signaling pathways to consider when designing or evaluating new generations of CARs.

  2. Patterns of mercury and methylmercury bioaccumulation in fish species downstream of a long-term mercury-contaminated site in the lower Ebro River (NE Spain). (United States)

    Carrasco, Luis; Barata, Carlos; García-Berthou, Emili; Tobias, Aurelio; Bayona, Josep M; Díez, Sergi


    Since the 19th century, large amounts of industrial waste were dumped in a reservoir adjacent to a chlor-alkali plant in the lower Ebro River (NE Spain). Previous toxicological analysis of carp populations inhabiting the surveyed area have shown that the highest biological impact attributable to mercury pollution occurred downstream of the discharge site. However, mercury speciation in fish from this polluted area has not been addressed yet. Thus, in the present study, piscivorous European catfish (Silurus glanis) and non-piscivorous common carp (Cyprinus carpio) were selected, to investigate the bioavailability and bioaccumulation capacities of both total mercury (THg) and methylmercury (MeHg) at the discharge site and downstream points. Multiple Correspondence Analysis (MCA) was applied to reduce the dimensionality of the data set, and Multiple Linear Regression (MLR) models were fitted in order to assess the relationship between both Hg species in fish and different variables of interest. Mercury levels in fish inhabiting the dam at the discharge site were found to be approximately 2-fold higher than those from an upstream site; while mercury pollution progressively increased downstream of the hot spot. In fact, both THg and MeHg levels at the farthest downstream point were 3 times greater than those close to the waste dump. This result clearly indicates downstream transport and increased mercury bioavailability as a function of distance downstream from the contamination source. A number of factors may affect both the downstream transport and increased Hg bioavailability associated with suspended particulate matter (SPM) and dissolved organic carbon (DOC). Copyright © 2011 Elsevier Ltd. All rights reserved.

  3. Interactive Learning-driven Innovation in Upstream-Downstream Relations

    DEFF Research Database (Denmark)

    Machikita, Tomohiro; Ueki, Yasushi


    with new technologies and new markets. However, this is not true for simple improvement of products or process innovation. Mutual exchanges with engineers between producers and suppliers within a chain can be expected to play an important role in the case of costly innovation and in situations unknown......This paper presents a simple framework of the innovations that result from interfirm learning through exchanges of engineers in upstream-downstream relations within a production chain. To examine the framework, we empirically investigate the impact of mutual knowledge exchanges on product...... and process innovation using a survey of firm's self-reporting customer and supplier data in Indonesia, the Philippines, Thailand and Vietnam. Evidence from interconnected firms within a production chain suggests that firms with mutual exchanges between engineers and customers achieved product innovations...

  4. Efficient industry configurations in downstream gas markets. An empirical assessment

    Energy Technology Data Exchange (ETDEWEB)

    Casarin, Ariel A. [IAE Escuela de Direccion y Negocios, Universidad Austral, Buenos Aires (Argentina)


    This paper examines the production technology of the downstream gas industry in order to provide some useful insights into its efficient structure by looking at the optimal size of firms and the productive efficiency reasons for and against their vertical integration. The analysis is based on a restricted cost function model estimated using firm level data for Argentina and Great Britain. The findings provide evidence for the presence of vertical diseconomies between stages. Results indicate that a single transmitter is able to produce the industry's output at lower costs for large market sizes and that several regional firms are able to operate without sacrificing scale economies if gas distribution is integrated with supply. The findings also indicate that a gas retailer experiences constant returns to scale when it supplies a large customer base. Liberalisation could thus result in oligopolistic industry configurations. (Author)

  5. Downstream Processability of Crystal Habit-Modified Active Pharmaceutical Ingredient

    DEFF Research Database (Denmark)

    Pudasaini, Nawin; Upadhyay, Pratik Pankaj; Parker, Christian Richard


    of six representative crystal habits of 5-ASA (needles, plates, rectangular bars, rhombohedrals, elongated hexagons, and spheroids) in the context of direct compression using ring shear tester, flow rate analyzer, and instrumented tablet press. As expected, needles were very cohesive, had low flow rate...... and tabletability, creating significant processability difficulties on a production scale. However, such a habit can be adapted to the needs of downstream processing. To this end, we modified the needle-like crystal habit of the model API 5-aminosalicylic acid (5-ASA). This study reports processability assessment...... (1.0 ± 0.08 mg/s), and low bulk density (0.14 ± 0.01 g/mL) but showed better tabletability, whereas the opposite was observed with more isotropic crystal habits. For instance, spheroids, elongated hexagons, and rhombohedrals were easy/free-flowing and had high bulk densities (≥0.5 g/mL), but final...

  6. Allogeneic cell therapy bioprocess economics and optimization: downstream processing decisions. (United States)

    Hassan, Sally; Simaria, Ana S; Varadaraju, Hemanthram; Gupta, Siddharth; Warren, Kim; Farid, Suzanne S


    To develop a decisional tool to identify the most cost effective process flowsheets for allogeneic cell therapies across a range of production scales. A bioprocess economics and optimization tool was built to assess competing cell expansion and downstream processing (DSP) technologies. Tangential flow filtration was generally more cost-effective for the lower cells/lot achieved in planar technologies and fluidized bed centrifugation became the only feasible option for handling large bioreactor outputs. DSP bottlenecks were observed at large commercial lot sizes requiring multiple large bioreactors. The DSP contribution to the cost of goods/dose ranged between 20-55%, and 50-80% for planar and bioreactor flowsheets, respectively. This analysis can facilitate early decision-making during process development.

  7. From gravel to sand. Downstream fining of bed sediments in the lower river Rhine

    NARCIS (Netherlands)

    Frings, R.M.


    A common characteristic of many rivers is the tendency for bed sediments to become finer in downstream direction. This phenomenon, which is generally known as downstream fining, has a strong effect on the morphologic and hydrodynamic behaviour of a river. The fundamental causes of downstream

  8. Downstream cumulative effects of land use on freshwater communities (United States)

    Kuglerová, L.; Kielstra, B. W.; Moore, D.; Richardson, J. S.


    Many streams and rivers are subject to disturbance from intense land use such as urbanization and agriculture, and this is especially obvious for small headwaters. Streams are spatially organized into networks where headwaters represent the tributaries and provide water, nutrients, and organic material to the main stems. Therefore perturbations within the headwaters might be cumulatively carried on downstream. Although we know that the disturbance of headwaters in urban and agricultural landscapes poses threats to downstream river reaches, the magnitude and severity of these changes for ecological communities is less known. We studied stream networks along a gradient of disturbance connected to land use intensity, from urbanized watersheds to watersheds placed in agricultural settings in the Greater Toronto Area. Further, we compared the patterns and processes found in the modified watershed to a control watershed, situated in a forested, less impacted landscape. Preliminary results suggest that hydrological modifications (flash floods), habitat loss (drainage and sewer systems), and water quality issues of small streams in urbanized and agricultural watersheds represent major disturbances and threats for aquatic and riparian biota on local as well as larger spatial scales. For example, communities of riparian plants are dominated by species typical of the land use on adjacent uplands as well as the dominant land use on the upstream contributing area, instead of riparian obligates commonly found in forested watersheds. Further, riparian communities in disturbed environments are dominated by invasive species. The changes in riparian communities are vital for various functions of riparian vegetation. Bank erosion control is suppressed, leading to severe channel transformations and sediment loadings in urbanized watersheds. Food sources for instream biota and thermal regimes are also changed, which further triggers alterations of in-stream biological communities

  9. Downstream evolution of unconfined vortices: mechanical and thermal aspects (United States)

    Pérez-Saborid, M.; Herrada, M. A.; Gómez-Barea, A.; Barrero, A.


    We present a numerical study of the downstream evolution (mechanical and thermal) of vortex-jet cores whose velocity and temperature fields far from the axis match a family of inviscid and non-conducting vortices. The far-velocity field is rotational, except for a particular case which corresponds to the well-known Long's vortex. The evolution of the vortex core depends on both the conditions at a certain upstream station, characterized by the dimensionless value of the velocity at the axis, and a dimensionless swirling parameter L defined as the ratio of the values of the azimuthal and axial velocities outside the vortex core. This numerical study, based on the quasi-cylindrical approximation (QC) of the Navier Stokes equations, determines the conditions under which the vortex evolution proceeds smoothly, eventually reaching an asymptotic self-similar behaviour as described in the literature (Fernández-Feria, Fernández de la Mora & Barrero 1995; Herrada, Pérez-Saborid & Barrero 1999), or breaks in a non-slender solution (vortex breakdown). In particular, the critical value L = Lb(a) beyond which vortex breakdown occurs downstream is a function of a dimensionless parameter a characterizing the axial momentum of the vortex jet at an initial upstream station. It is found numerically that for very large values of a this vortex breakdown criterion tends to an asymptote which is precisely the value L = L* predicted by the self-similar analysis, and beyond which a self-similar structure of the vortex core does not exist. In addition, the computation of the total temperature field provides useful information on the physical mechanisms responsible for the thermal separation phenomenon observed in Ranque Hilsch tubes and other swirling jet devices. In particular, the mechanical work of viscous forces which gives rise to an intense loss of kinetic energy during the initial stages of the evolution has been identified as the physical mechanism responsible for thermal

  10. A Copernicus downstream service for surface displacement monitoring in Germany (United States)

    Cahyadi Kalia, Andre; Frei, Michaela; Lege, Thomas


    SAR Interferometry is a powerful technique able to detect and monitor various surface displacements caused by e.g. gravitative mass movement, subrosion, groundwater extraction, fluid injection, natural gas extraction. These processes can e.g. cause damage to buildings, infrastructure, affect ecosystems, agriculture and the economic use of the geological underground by influencing the hydro(geo)logical setting. Advanced techniques of interferometric processing (Persistent Scatterer Interferometry, PSI) allow highly precise displacement measurements (mm precision) by analyzing stacks of SAR imagery. The PSI mapping coverage can be increased to entire nations by using several adjacent satellite tracks. In order to assist the operational use of this technique a German-wide, officially approved, PSI dataset is under development. The intention of this presentation is to show i) the concept of the Copernicus downstream service for surface displacement monitoring in Germany and ii) a pilot study to exemplarily demonstrate the workflow and potential products from the Copernicus downstream service. The pilot study is focusing on the built up of an officially approved wide-area PSI dataset. The study area covers an area of more than 30.000 km² and is located in the Northwest German Basin. Several natural processes (e.g. compaction of marine sediments, peat loss) and anthropogenic activities (e.g. natural gas extraction, rock salt mining) are causing surface displacements in the study area. The PSI analysis is based on six ERS-1/-2 data stacks covering the timespan from 1992 until 2001. Each data stack consists of 49 to 73 ERS-1/-2 SAR images. A comparison of the PSI results with thematic data (e.g. volume and location of extracted natural gas) strongly indicates that a part of the detected land subsidence is caused by natural gas extraction. Furthermore, land subsidence caused by e.g. fluid injection and rock salt mining were successfully detected by the PSI analysis.

  11. seed oil

    African Journals Online (AJOL)


    The foam height of the soap was found to be 2.0 cm which is lower than that of Jatropha oil soap(5.4cm), Sesame oil soap(4.8cm), Cotton seed oil soap(4.5cm) and shea nut soap(4.2cm),t higher than that of Castor oil soap(1.6cm) and Castor glycerine soap(1.4cm). The soap was milk in colour and slightly soluble in distilled ...

  12. Activity of methane oxidizing bacteria along the River Elbe downstream to its estuary (United States)

    Matoušu, A.; Šimek, K.; Bussmann, I.


    Contribution of rivers and estuarine systems to the global methane (CH4) budget is still not clear yet and for improving the estimations on the CH4 emission it is essential to cover the whole natural system in large-scale studies. In this context we quantified the activity of methane oxidizing bacteria (as a microbial "biofilter") over almost two seasons along a large European river system, the river Elbe, from its source in the Czech Republic towards to its estuary in the North Sea. Determination of methane oxidation rate was measured using a tritiated CH4 radiotracer technique. Methane concentrations in the water column were analyzed by the headspace method. The range of CH4concentrations and related microbial oxidation activities displayed a strong increase from the upper river parts, which includes mainly natural river, to the polluted downstream canalized parts of the river with high CH4concentrations and microbial activities, where anaerobic sediments occur. In the water column of the estuarine zone a sharp decrease of the CH4 concentration- and CH4 oxidation rates is mainly influenced by the increasing salinity. Additional parameters (temperature, dissolved oxygen, amount of suspended particular matter and nutrient content) are possible factors influencing the methanotrophic activity. Further investigations will compare the population structure of MOB at the different sites along the whole transect.

  13. Critical interactionism: an upstream-downstream approach to health care reform. (United States)

    Martins, Diane Cocozza; Burbank, Patricia M


    Currently, per capita health care expenditures in the United States are more than 20% higher than any other country in the world and more than twice the average expenditure for European countries, yet the United States ranks 37th in life expectancy. Clearly, the health care system is not succeeding in improving the health of the US population with its focus on illness care for individuals. A new theoretical approach, critical interactionism, combines symbolic interactionism and critical social theory to provide a guide for addressing health care problems from both an upstream and downstream approach. Concepts of meaning from symbolic interactionism and emancipation from critical perspective move across system levels to inform and reform health care for individuals, organizations, and societies. This provides a powerful approach for health care reform, moving back and forth between the micro and macro levels. Areas of application to nursing practice with several examples (patients with obesity; patients who are lesbian, gay, bisexual, and transgender; workplace bullying and errors), nursing education, and research are also discussed.

  14. Essential oils: renewal of interest and toxicity. (United States)

    Vigan, Martine


    Essential oils are complex mixtures of substances from vegetable matter, the definition of which is based on their method of extraction. They are characterized by their ambivalence, their ambiguity and their disparity: plant families from which essential oils are extracted are numerous; the composition of each essential oil depends not only on the family but also on the part of the plant from which it is extracted, and sometimes on the soil where the plant grows, or even on the time of the harvest. Gas chromatography is therefore necessary to characterize an essential oil. Essential oils can be found in cosmetics, in drugs, and in food. They are natural substances, but natural is not synonymous with harmless. Evaluation of the toxicity of essential oils and European regulation are underway.

  15. Medium-Term Oil Market Report 2007

    Energy Technology Data Exchange (ETDEWEB)



    How much oil will the world consume in 2012? What role will OPEC play in global oil production? Will biofuels become an important part of the oil market? How will the refinery sector cope? The International Energy Agency (IEA) Medium-Term Oil Market Report tackles these questions, adopting a perspective that goes beyond the traditional short-term market analysis provided in the IEA Oil Market Report. Drawing on current futures curves and the investment threshold for upstream projects, the Medium-Term Oil Market Report analyses how global demand and supply balances may develop. By assessing all firmly planned upstream and downstream projects worldwide, this report forecasts supply and demand potential for crude and petroleum products over the next five years. The results provide an invaluable insight into vital issues such as surplus production capacity and product supply. An essential report for all policymakers, market analysts, energy experts and anyone interested in understanding and following oil market trends, the Medium-Term Oil Market Report is a further element of the strong commitment of the IEA to improving and expanding the quality, timeliness and accuracy of energy data and analysis.

  16. Electron acceleration at nearly perpendicular collisionless shocks. 3: Downstream distributions (United States)

    Krauss-Varban, D.


    Spacecraft observations at the Earth's bow shock and at interplanetary shocks have established that the largest fluxes of accelerated suprathermal electrons occur in so-called shock spike events immediately downstream of the shock ramp. Previous theoretical efforts have mainly focused on explaining upstream energetic electron beams. Here we investigate the general motion and acceleration of energetic electrons in a curved, nearly perpendicular shock by numerically integrating the orbits of solar wind halo electrons in shock fields generated by a hybrid simulation (core electron fluid and kinetic ions). Close to the angle Theta(sub Bn) = 90 degs between the upstream magnetic field and shock normal, the calculations result in a (perpendicular) temperature increase proportional to the magnetic field ratio and give the highest phase space densities in the overshoot. For a steep distribution, the temperature change can correspond to an enhancement of the distribution by several orders of magnitude. These results are in agreement with predictions from adiabatic mapping. With smaller angles Theta(sub Bn), the overshoot and downstream densities fall off quickly, because the adiabatic energy gain is less and fewer electrons transmit. The shock curvature also leads to an accumulation of electrons close to 90 degs. Without pitch angle scattering, energization is only significant within a few (approximately 5 to 10 degs) degrees of the point of tangency. However, shock spike events appear to be observed more easily and farther away from 90 degs. Given that over a region of several degrees around 90 degs the theory gives enhancements of up to approximately 4 orders of magnitude, such electrons could in principle account for the typically observed enhancements of 1 to 2 orders of magnitude, if they were distributed over Theta(sub Bn). To test the idea that scattering could efficiently redistribute the energetic electrons, we have conducted test particle simulations in which

  17. Corrosion impact of reductant on DWPF and downstream facilities

    Energy Technology Data Exchange (ETDEWEB)

    Mickalonis, J. I. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Imrich, K. J. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Jantzen, C. M. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Murphy, T. H. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL); Wilderman, J. E. [Savannah River Site (SRS), Aiken, SC (United States). Savannah River National Lab. (SRNL)


    Glycolic acid is being evaluated as an alternate reductant in the preparation of high level waste for the Defense Waste Processing Facility (DWPF) at the Savannah River Site (SRS). During processing, the glycolic acid is not completely consumed and small quantities of the glycolate anion are carried forward to other high level waste (HLW) facilities. The impact of the glycolate anion on the corrosion of the materials of construction throughout the waste processing system has not been previously evaluated. A literature review had revealed that corrosion data in glycolate-bearing solution applicable to SRS systems were not available. Therefore, testing was recommended to evaluate the materials of construction of vessels, piping and components within DWPF and downstream facilities. The testing, conducted in non-radioactive simulants, consisted of both accelerated tests (electrochemical and hot-wall) with coupons in laboratory vessels and prototypical tests with coupons immersed in scale-up and mock-up test systems. Eight waste or process streams were identified in which the glycolate anion might impact the performance of the materials of construction. These streams were 70% glycolic acid (DWPF feed vessels and piping), SRAT/SME supernate (Chemical Processing Cell (CPC) vessels and piping), DWPF acidic recycle (DWPF condenser and recycle tanks and piping), basic concentrated recycle (HLW tanks, evaporators, and transfer lines), salt processing (ARP, MCU, and Saltstone tanks and piping), boric acid (MCU separators), and dilute waste (HLW evaporator condensate tanks and transfer line and ETF components). For each stream, high temperature limits and worst-case glycolate concentrations were identified for performing the recommended tests. Test solution chemistries were generally based on analytical results of actual waste samples taken from the various process facilities or of prototypical simulants produced in the laboratory. The materials of construction for most vessels

  18. seed oil

    African Journals Online (AJOL)


    ABSTRACT. Neem seed oil from the neem tree (Azadiracta indica) finds wide usage one of which is its utilization for cosmetics particularly soap products. The chemical analysis of seed oil was carried out using the methods reported by AOAC (1998), Akpan et al., (2006) and Bassir, (1978) which revealed that it had.

  19. Expression of ZmLEC1 and ZmWRI1 Increases Seed Oil Production in Maize

    National Research Council Canada - National Science Library

    Bo Shen; William B. Allen; Peizhong Zheng; Changjiang Li; Kimberly Glassman; Jerry Ranch; Douglas Nubel; Mitchell C. Tarczynski


    ...% but reduces seed germination and leaf growth in maize. To uncouple oil increase from the undesirable agronomic traits, we identified a LEC1 downstream transcription factor, maize WRINKLED1 (ZmWRI1...

  20. Oil politics and violence in postcolonial Niger Delta drama | Otu ...

    African Journals Online (AJOL)

    Oil politics and violence in postcolonial Niger Delta drama. ... African state and an oppressive colonial or neo-colonial European power. ... and as such contemporary postcolonial Niger Delta drama can be described as drama of individualism ...

  1. Modelling consumer intakes of vegetable oils and fats. (United States)

    Tennant, David; Gosling, John Paul


    Vegetable oils and fats make up a significant part of the energy intake in typical European diets. However, their use as ingredients in a diverse range of different foods means that their consumption is often hidden, especially when oils and fats are used for cooking. As a result, there are no reliable estimates of the consumption of different vegetable oils and fats in the diet of European consumers for use in, for example, nutritional assessments or chemical risk assessments. We have developed an innovative model to estimate the consumption of vegetable oils and fats by European Union consumers using the European Union consumption databases and elements of probabilistic modelling. A key feature of the approach is the assessment of uncertainty in the modelling assumptions that can be used to build user confidence and to guide future development.

  2. fifty years of oil exploration in nigeria: the paradox of plenty

    African Journals Online (AJOL)


    against corruption. KEYWORDS: Resource curse, Nigeria, Oil and Gas, GDP, Infrastructure, Corruption. INTRODUCTION. The history of oil exploration in Nigeria ..... as the country failed to invest in the downstream sector of the petroleum industry. Table 4: Economic Indicators as at 2003. Parameters. Brazil. Mexico. Ghana.

  3. A strategic model of European gas supply (GASMOD)

    Energy Technology Data Exchange (ETDEWEB)

    Holz, Franziska [DIW Berlin, German Institute of Economic Research, Koenigin-Luise-Str. 5, D-14195 Berlin (Germany); Hirschhausen, Christian von [DIW Berlin, German Institute of Economic Research, Koenigin-Luise-Str. 5, D-14195 Berlin (Germany); Chair of Energy Economics and Public Sector Management, TU Dresden, Department of Business Management and Economics, D-01062 Dresden (Germany); Kemfert, Claudia [DIW Berlin, German Institute of Economic Research, Koenigin-Luise-Str. 5, D-14195 Berlin (Germany); Humboldt University Berlin, Spandauer Str. 1, D-10178 Berlin (Germany)


    This paper presents a model of the European natural gas supply, GASMOD, which is structured as a two-stage-game of successive natural gas exports to Europe (upstream market) and wholesale trade within Europe (downstream market) and which explicitly includes infrastructure capacities. We compare three possible market scenarios: Cournot competition in both markets, perfect competition in both markets, and perfect competition in the downstream with Cournot competition in the upstream market (EU liberalization). We find that Cournot competition in both markets is the most accurate representation of today's European natural gas market, where suppliers at both stages generate a mark-up at the expense of the final customer (double marginalization). Our results yield a diversified supply portfolio with newly emerging (LNG) exporters gaining market shares. Enforcing competition in the European downstream market would lead to lower prices and higher quantities by avoiding the welfare-reducing effects of double marginalization. Binding infrastructure capacity restrictions strongly influence the results, and we identify bottlenecks mainly for intra-European trade relations whereas transport capacity in the upstream market is globally sufficient in the Cournot scenario. (author)

  4. Three-dimensional flow characteristics in the downstream region of a butterfly-type valve used in air-conditioning systems

    Energy Technology Data Exchange (ETDEWEB)

    Park, S.W. [Kumoh National University of Technology Graduate School, Kumi (Korea); Lee, S.W. [Kumoh National University of Technology, Kumi (Korea)


    Oil-film flow visualizations and three-dimensional flow measurements have been conducted in the downstream region of a butterfly-type valve used in air-conditioning systems, with the variation of a disk open angle. The flow visualizations in the flow symmetry plane show that there are a pair of counter-rotating separation/recirculation zones as wall as two jet-like near-wall flows. These flow disturbances are strongly depends on the disk open angle. Based on the flow visualization, a qualitative flow model is suggested in the near-field and downstream region of the valve disk. For a small disk open angle, the mean velocities and turbulent intensities have relatively small values in the near-field of the valve disk, but they do not show uniform distributions even in some downstream region. With an increment of the disk open angle, mean velocity variations and turbulent intensities are greatly increased in the immediate downstream region, but uniform distributions are quickly resumed as departing from the valve disk. The mass flow rate remains nearly constant for the disk open angles less than 30 degrees, meanwhile it strongly depends on the disk open angles between 45 and 75 degrees. The pressure loss is found to be about zero for the disk open angles less than 45 degrees, but is substantially increased for those larger than 75 degrees. (author). 9 refs., 10 figs.

  5. Hydroeconomic optimization of reservoir management under downstream water quality constraints (United States)

    Davidsen, Claus; Liu, Suxia; Mo, Xingguo; Holm, Peter E.; Trapp, Stefan; Rosbjerg, Dan; Bauer-Gottwein, Peter


    A hydroeconomic optimization approach is used to guide water management in a Chinese river basin with the objectives of meeting water quantity and water quality constraints, in line with the China 2011 No. 1 Policy Document and 2015 Ten-point Water Plan. The proposed modeling framework couples water quantity and water quality management and minimizes the total costs over a planning period assuming stochastic future runoff. The outcome includes cost-optimal reservoir releases, groundwater pumping, water allocation, wastewater treatments and water curtailments. The optimization model uses a variant of stochastic dynamic programming known as the water value method. Nonlinearity arising from the water quality constraints is handled with an effective hybrid method combining genetic algorithms and linear programming. Untreated pollutant loads are represented by biochemical oxygen demand (BOD), and the resulting minimum dissolved oxygen (DO) concentration is computed with the Streeter-Phelps equation and constrained to match Chinese water quality targets. The baseline water scarcity and operational costs are estimated to 15.6 billion CNY/year. Compliance to water quality grade III causes a relatively low increase to 16.4 billion CNY/year. Dilution plays an important role and increases the share of surface water allocations to users situated furthest downstream in the system. The modeling framework generates decision rules that result in the economically efficient strategy for complying with both water quantity and water quality constraints.

  6. Gellan Gum: Fermentative Production, Downstream Processing and Applications

    Directory of Open Access Journals (Sweden)

    Ishwar B. Bajaj


    Full Text Available The microbial exopolysaccharides are water-soluble polymers secreted by microorganisms during fermentation. The biopolymer gellan gum is a relatively recent addition to the family of microbial polysaccharides that is gaining much importance in food, pharmaceutical and chemical industries due to its novel properties. It is commercially produced by C. P. Kelco in Japan and the USA. Further research and development in biopolymer technology is expected to expand its use. This article presents a critical review of the available information on the gellan gum synthesized by Sphingomonas paucimobilis with special emphasis on its fermentative production and downstream processing. Rheological behaviour of fermentation broth during fermentative production of gellan gum and problems associated with mass transfer have been addressed. Information on the biosynthetic pathway of gellan gum, enzymes and precursors involved in gellan gum production and application of metabolic engineering for enhancement of yield of gellan gum has been specified. Characteristics of gellan gum with respect to its structure, physicochemical properties, rheology of its solutions and gel formation behaviour are discussed. An attempt has also been made to review the current and potential applications of gellan gum in food, pharmaceutical and other industries.

  7. Oxidative stress and its downstream signaling in aging eyes. (United States)

    Pinazo-Durán, María Dolores; Gallego-Pinazo, Roberto; García-Medina, Jose Javier; Zanón-Moreno, Vicente; Nucci, Carlo; Dolz-Marco, Rosa; Martínez-Castillo, Sebastián; Galbis-Estrada, Carmen; Marco-Ramírez, Carla; López-Gálvez, Maria Isabel; Galarreta, David J; Díaz-Llópis, Manuel


    Oxidative stress (OS) and its biomarkers are the biochemical end point of the imbalance between reactive oxygen species (ROS) production and the ability of the antioxidant (AOX) biological systems to fight against oxidative injury. We reviewed the role of OS and its downstream signaling in aging eyes. A search of the literature and current knowledge on the physiological and pathological mechanisms of OS were revisited in relation to the eyes and the aging process. Most prevalent ocular diseases have been analyzed herein in relation to OS and nutraceutic supplements, such as dry-eye disorders, glaucoma, age-related macular degeneration, and diabetic retinopathy. Clinical, biochemical, and molecular data from anterior and posterior eye segment diseases point to OS as the common pathogenic mechanism in the majority of these ocular disorders, many of which are pathologies causing visual impairment, blindness, and subsequent loss of life quality. Studies with nutraceutic supplements in aging eye-related pathologies have also been reviewed. OS, nutritional status, and nutraceutic supplements have to be considered within the standards of care of older ophthalmologic patients. OS biomarkers and surrogate end points may help in managing the aging population with ocular diseases.

  8. Downstream Processing, Formulation Development and Antithrombotic Evaluation of Microbial Nattokinase. (United States)

    Kapoor, Rohit; Harde, Harshad; Jain, Sanyog; Panda, Amulya Kumar; Panda, Bibhu Prasad


    The present research work describes the downstreaming of nattokinase (NK) produced by Bacillus subtilis under solid state fermentation; and the role of efficient oral formulation of purified NK in the management of thrombotic disorders. Molecular weight of purified NK was estimated to be 28 kDa with specific activity of 504.4 FU/mg. Acid stable nattokinase loaded chitosan nanoparticles (sNLCN) were fabricated for oral delivery of this enzyme. Box-Behnken design (BBD) was employed to investigate and validate the effect of process (independent) variables on the quality attributes (dependent variables) of nanoparticles. The integrity, conformational stability and preservation of fibrinolytic activity of NK (in both free and sNLCN forms) were established by SDS-PAGE, CD analysis and in vitro clot lytic examination, respectively. A 'tail thrombosis model' demonstrated significant decrease in frequency of thrombosis in Wistar rats upon peroral administration of sNLCN in comparison with negative control and free NK group. Furthermore, coagulation analysis, namely the measurement of prothrombin and activated partial thromboplastin time illustrated that sNLCN showed significantly (p < 0.001) higher anti-thrombotic potential in comparison to the free NK. Further, sNLCN showed anti-thrombotic profile similar to warfarin. This study signifies the potential of sNLCN in oral delivery of NK for the management of thrombotic disorders.

  9. Flume experiments on scour downstream of wood stream restoration structures (United States)

    Pagliara, Stefano; Kurdistani, Sahameddin Mahmoudi


    River restoration aims to improve physical natural form and processes of a river. Techniques to control the riverbed, stabilize channel alignment, protect stream banks, and rebuild the natural habitat are an important part of river restoration projects. Rivers can be stabilized and habitat restored through techniques such as rebuilding meanders and pool-riffle sequences and managing large wood. Structures that limit channel width to accelerate the normal flows through the constricted section are referred to as stream deflectors. Single-wing, double-wing and triangular deflectors are the most commonly used types of this measure. Log-frame deflectors consist of a triangular log frame filled with rock. Deflector constructions singly or in series in low gradient meandering streams, divert base flows toward the center of the channel and, under certain conditions, increase the depth and velocity of flow thereby creating scour pools and enhancing fish habitat. Scour characteristics and morphologies downstream of log-frame deflectors have been analyzed at the hydraulic laboratory of the University of Pisa. All experiments have been carried out in clear water conditions. The results showed that the tailwater depth plays an important role on scour characteristics. In addition, it was experimentally proven that using log-frame deflectors instead of log-deflectors result in a better river bank protection. In this case, for all the tested hydraulic conditions, the scour hole never occurred close to the channel bank. Useful empirical relationships have been proposed in order to evaluate the main features of the scour geometry.

  10. Downstream migration and multiple dam passage by Atlantic Salmon smolts (United States)

    Nyqvist, D.; McCormick, Stephen; Greenberg, L.; Ardren, W.R.; Bergman, E.; Calles, O.; Castro-Santos, Theodore R.


    The purpose of this study was to investigate behavior and survival of radio-tagged wild and hatchery-reared landlocked Atlantic Salmon Salmo salar smolts as they migrated past three hydropower dams equipped with fish bypass solutions in the Winooski River, Vermont. Among hatchery-reared smolts, those released early were more likely to initiate migration and did so after less delay than those released late. Once migration was initiated, however, the late-released hatchery smolts migrated at greater speeds. Throughout the river system, hatchery-reared fish performed similarly to wild fish. Dam passage rates varied between the three dams and was highest at the dam where unusually high spill levels occurred throughout the study period. Of the 50 fish that did migrate downstream, only 10% managed to reach the lake. Migration success was low despite the presence of bypass solutions, underscoring the need for evaluations of remedial measures; simply constructing a fishway is not synonymous with providing fish passage.

  11. Synthetic Routes to Methylerythritol Phosphate Pathway Intermediates and Downstream Isoprenoids. (United States)

    Jarchow-Choy, Sarah K; Koppisch, Andrew T; Fox, David T


    Isoprenoids constitute the largest class of natural products with greater than 55,000 identified members. They play essential roles in maintaining proper cellular function leading to maintenance of human health, plant defense mechanisms against predators, and are often exploited for their beneficial properties in the pharmaceutical and nutraceutical industries. Most impressively, all known isoprenoids are derived from one of two C5-precursors, isopentenyl diphosphate (IPP) or dimethylallyl diphosphate (DMAPP). In order to study the enzyme transformations leading to the extensive structural diversity found within this class of compounds there must be access to the substrates. Sometimes, intermediates within a biological pathway can be isolated and used directly to study enzyme/pathway function. However, the primary route to most of the isoprenoid intermediates is through chemical catalysis. As such, this review provides the first exhaustive examination of synthetic routes to isoprenoid and isoprenoid precursors with particular emphasis on the syntheses of intermediates found as part of the 2C-methylerythritol 4-phosphate (MEP) pathway. In addition, representative syntheses are presented for the monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), triterpenes (C30) and tetraterpenes (C40). Finally, in some instances, the synthetic routes to substrate analogs found both within the MEP pathway and downstream isoprenoids are examined.


    Directory of Open Access Journals (Sweden)

    Montani Guido


    Full Text Available The European project is facing a crisis. Citizens no longer understand what the EU is about. Young people and the new ruling class have forgotten the clear message of the European project launched just after the Second World War "No wars ever again among Europeans." The founding fathers of the European Union are mentioned in history textbooks, but today Europe is felt as an irritating bureaucracy. In Europe, peace and economic stability are considered as a natural state, a gift from above. Why keep a useless EU alive? The state of the European Union is swiftly degenerating. In almost all the member states, the anti-European forces are gaining ground. Populism is not a new ideology and is not necessarily European: let's recall Peronism. In today's Europe populism is the new manifestation of nationalism. In Italy the Lega Nord is in Berlusconi's eurosceptic government. In France, the National Front is endangering UMP's hegemony. In Belgium the rows between the Flemish and the Walloons threatens the state's unity. In the Netherlands, Hungary, the Czech Republic, Austria and Finland, populist forces are either in the government or strongly influencing the government. National-populism is different from the nationalism of the past. De Gaulle's nationalism was an ideology founded on the "grandeur" of France's history and on a certain idea of Europe, which was "l'Europe de patrie", a kind of European unity accepting French leadership in world politics. Today national-populism is a form of micro-nationalism: it opposes the European project but without having a serious alternative. This is why populism is dangerous. Its real goal is not only the breaking down of the European Union but also the disintegration of the old nation states into micro-ethnic states, as what happened in former Yugoslavia.

  13. GMES and Down-stream Services Following User Requirements: Examples on Regional And Coastal Scale (United States)

    Noehren, I.; Breitbach, G.; Schroeder, F.


    MyOcean as part of the Global Monitoring for Environment and Security (GMES) services provides information on the state of the oceans on a regular basis. The products are delivered on a global as well as on a regional scale like EU, covering the physical state of the ocean and primary ecosystem parameters. For local or coastal scales these Core Services very often do not meet the requirements of the potential end-user who needs information on e. g. marine safety, oil spills, marine resources and coastal management. For these local information needs Downstream Services derived from GMES Core Services, e.g. MyOcean products, but also directly from observation infrastructure are necessary. With Cosyna (Coastal Observation System for Northern and Arctic Seas) a national project between MyOcean and downstream services is established. The core of the project is an integrated pre-operational observation system which combines in-situ observations and remote sensing procedures with numerical models to obtain synoptic data sets of the southern North Sea and make basic infrastructure and continuous data available to the scientific community. The network provides intermediate products in terms of quality-assured time series and maps with high temporal and spatial resolution; end-users might produce their own end products. Integrated products cover processed information based on a combination of different observations and models, accompanied by instructions of use and optionally by interpretations. To enhance operational services in coastal areas improved forecasts with coupled models and data assimilation are developed in the EC funded FIELD_AC project (Fluxes, Interactions and Environment at the Land-Ocean Boundary. Downscaling, Assimilation and Coupling). The application area of the German partner is the German Bight. By means of a strong interaction with the Cosyna observational network main emphasis is laid on the user needs (e.g. of national agencies, coastal and harbour

  14. Forecasting European thermal coal spot prices

    Directory of Open Access Journals (Sweden)

    Alicja Krzemień


    Finally, in order to analyse the time series model performance a Generalized Regression Neural Network (GRNN was used and its performance compared against the whole AR(2 process. Empirical results obtained confirmed that there is no statistically significant difference between both methods. The GRNN analysis also allowed pointing out the main drivers that move the European Thermal Coal Spot prices: crude oil, USD/CNY change and supply side drivers.

  15. European single-hull regulation in force

    Energy Technology Data Exchange (ETDEWEB)

    Rogers, Michael


    The European Union (EU)has decided that from 21 October 2003 no single-hull tanker carrying heavy grades of oil will be permitted to enter or leave ports or offshore installations or anchor in areas under the jurisdiction of the EU member states. Some of the provisions of the EU regulation will not be in force until 2010. The article looks back on what has led up to to the current regulations, beginning with the Titanic disaster of 1914.

  16. Sources for increased DOC-concentrations in the groundwater downstream of the landfill Hohne (DEA); Ursachen erhoehter DOC-Konzentrationen im Grundwasserabstrom am Beispiel der Deponie Hohne (DEA)

    Energy Technology Data Exchange (ETDEWEB)

    Bahlmann, E.; Seifert, R. [Hamburg Univ. (Germany). Inst. fuer Geologie; Eschenbach, A.; Kleinschmidt, V. [Hamburg Univ. (Germany). Inst. fuer Bodenkunde


    Construction waste together with drilling mud and oil-contaminated soil had been deposited in the landfill Hohne from 1971. Four groundwater monitoring sites had been installed: one monitoring site upstream and three sites downstream of the landfill in three different directions. Downstream of the landfill increased concentrations of chloride, sulphate, sodium and DOC (dissolved organic carbon) had been measured over a period of years. Particularly the source of the DOC has remained unclear. Assumptions were (i) leaking of contaminants from the landfill and degradation under the landfill by microbes or plants or (ii) leaching of DOC from the soil under the landfill caused by a change in the redox potential. The determination of the DOC source was the major subject of this study.

  17. Advances in direct transesterification of algal oils from wet biomass. (United States)

    Park, Ji-Yeon; Park, Min S; Lee, Young-Chul; Yang, Ji-Won


    An interest in biodiesel as an alternative fuel for diesel engines has been increasing because of the issue of petroleum depletion and environmental concerns related to massive carbon dioxide emissions. Researchers are strongly driven to pursue the next generation of vegetable oil-based biodiesel. Oleaginous microalgae are considered to be a promising alternative oil source. To commercialize microalgal biodiesel, cost reductions in oil extraction and downstream biodiesel conversion are stressed. Herein, starting from an investigation of oil extraction from wet microalgae, a review is conducted of transesterification using enzymes, homogeneous and heterogeneous catalysts, and yield enhancement by ultrasound, microwave, and supercritical process. In particular, there is a focus on direct transesterification as a simple and energy efficient process that omits a separate oil extraction step and utilizes wet microalgal biomass; however, it is still necessary to consider issues such as the purification of microalgal oils and upgrading of biodiesel properties. Copyright © 2014 Elsevier Ltd. All rights reserved.

  18. Wind-Driven Ecological Flow Regimes Downstream from Hydropower Dams (United States)

    Kern, J.; Characklis, G. W.


    Conventional hydropower can be turned on and off quicker and less expensively than thermal generation (coal, nuclear, or natural gas). These advantages enable hydropower utilities to respond to rapid fluctuations in energy supply and demand. More recently, a growing renewable energy sector has underlined the need for flexible generation capacity that can complement intermittent renewable resources such as wind power. While wind power entails lower variable costs than other types of generation, incorporating it into electric power systems can be problematic. Due to variable and unpredictable wind speeds, wind power is difficult to schedule and must be used when available. As a result, integrating large amounts of wind power into the grid may result in atypical, swiftly changing demand patterns for other forms of generation, placing a premium on sources that can be rapidly ramped up and down. Moreover, uncertainty in wind power forecasts will stipulate increased levels of 'reserve' generation capacity that can respond quickly if real-time wind supply is less than expected. These changes could create new hourly price dynamics for energy and reserves, altering the short-term financial signals that hydroelectric dam operators use to schedule water releases. Traditionally, hourly stream flow patterns below hydropower dams have corresponded in a very predictable manner to electricity demand, whose primary factors are weather (hourly temperature) and economic activity (workday hours). Wind power integration has the potential to yield more variable, less predictable flows at hydro dams, flows that at times could resemble reciprocal wind patterns. An existing body of research explores the impacts of standard, demand-following hydroelectric dams on downstream ecological flows; but weighing the benefits of increased reliance on wind power against further impacts to ecological flows may be a novel challenge for the environmental community. As a preliminary step in meeting this

  19. Extraction and downstream processing of plant-derived recombinant proteins. (United States)

    Buyel, J F; Twyman, R M; Fischer, R


    Plants offer the tantalizing prospect of low-cost automated manufacturing processes for biopharmaceutical proteins, but several challenges must be addressed before such goals are realized and the most significant hurdles are found during downstream processing (DSP). In contrast to the standardized microbial and mammalian cell platforms embraced by the biopharmaceutical industry, there are many different plant-based expression systems vying for attention, and those with the greatest potential to provide inexpensive biopharmaceuticals are also the ones with the most significant drawbacks in terms of DSP. This is because the most scalable plant systems are based on the expression of intracellular proteins in whole plants. The plant tissue must therefore be disrupted to extract the product, challenging the initial DSP steps with an unusually high load of both particulate and soluble contaminants. DSP platform technologies can accelerate and simplify process development, including centrifugation, filtration, flocculation, and integrated methods that combine solid-liquid separation, purification and concentration, such as aqueous two-phase separation systems. Protein tags can also facilitate these DSP steps, but they are difficult to transfer to a commercial environment and more generic, flexible and scalable strategies to separate target and host cell proteins are preferable, such as membrane technologies and heat/pH precipitation. In this context, clarified plant extracts behave similarly to the feed stream from microbes or mammalian cells and the corresponding purification methods can be applied, as long as they are adapted for plant-specific soluble contaminants such as the superabundant protein RuBisCO. Plant-derived pharmaceutical proteins cannot yet compete directly with established platforms but they are beginning to penetrate niche markets that allow the beneficial properties of plants to be exploited, such as the ability to produce 'biobetters' with tailored

  20. Which tributaries disrupt downstream fining along gravel-bed rivers? (United States)

    Rice, Stephen


    Tributaries and other lateral sediment sources can have a significant impact on river bed sediment texture and, in turn, on channel form. Sufficiently voluminous or distinct sediment inputs redefine the mainstem grain-size distribution, punctuating downstream maturation and isolating a sequence of discrete sedimentary links. Within these links fining processes usually dominate, such that models of sorting and abrasion, when applied to individual links, provide reasonable predictions of grain-size change. Links represent the fundamental natural unit within which fining models can be tested, developed and applied. Identification of significant lateral sources is therefore important, yet, beyond vague references to relative tributary size, sediment load, and sediment calibre, no criteria exist for the a priori discrimination of such sources. In this paper a procedure for identifying significant lateral (tributary) sources, without the benefit of grain-size information, is outlined. A high-resolution characterisation of bed material texture along two Canadian gravel-bed rivers facilitated classification of all their perennial tributaries as either significant or insignificant. Three absolute tributary basin parameters and their relative counterparts, chosen to reflect the likely controls on tributary significance, are then used to develop a discriminant function which isolates a large proportion of significant tributaries while minimising incorrect classifications. Examination of consistently misclassified (anomalous) tributaries reveals the importance of lateral source spacing and of inconsistencies in the geomorphic history of the contributing basins. In turn, a general tributary categorisation procedure is suggested which includes a logistic regression model for attaching probability statements to individual classifications. The generality of the discriminant and logistic functions cannot be assessed because of the lack of other suitable data sets.

  1. Downstream Propagation of Thermal Pollution in Urban Streams (United States)

    Somers, K. A.; Urban, D. L.; Bernhardt, E. S.; Losordo, M.


    Cities create "heat islands" with air temperatures up to 12 degrees C greater than surrounding areas and impervious surface temperatures reaching 50 degrees C greater than the air. Streams that drain urban areas tend to be hotter at baseflow due to warmer air temperatures and decreased riparian canopy cover. Further, urban stormflow routes precipitation over hot impervious surfaces and through storm drains directly into streams, creating rapid changes in stream temperatures. The resulting alterations in stream thermal regimes directly stress aquatic organisms and indirectly lead to changes in stream microbial activity and dissolved oxygen concentrations. To date, there has been little work done to understand how urban heating of streams propagates downstream from thermal pollution sources. In response to this lack, we used a fiber optic distributed temperature sensor as well as multiple individual temperature loggers to measure high spatiotemporal resolution patterns of stream temperature along 1.5 km of Mud Creek in Durham, NC. Mud Creek originates in the storm drains of a suburban neighborhood, where high-density residential complexes with large amounts of impervious surface are connected directly to the stream. The stream flows in a confined channel alongside apartment complexes for 0.5 km before entering a protected forest area. At baseflow, we found temperature was heterogeneous and explained primarily by canopy openness, rather than the amount of development upstream of the location. During summer stormflows, stream temperatures became more homogeneous and increased by up to 4 degrees C due to runoff at the top of the reach. These peak temperatures were dampened to only 2 degrees C increases after 1 km of travel through mature forest. In contrast, a fully forested tributary to Mud Creek decreased in temperature for the same storm events. This spatial propagation of stormflow heat pulses will substantially limit our ability to protect urban stream ecosystems.

  2. Two Oils, Same Phenomena: Historicizing Exclusion, Poverty and ...

    African Journals Online (AJOL)

    Delta communities in the vortex of European imperialism, which suppressed the growth of a viable class of indigenous accumulators and entrepreneurs in the palm oil economy. It demonstrated that contemporary trends and phenomena only heightened when the crude oil economy penetrated and reconfigured Niger Delta ...

  3. Physicochemical characterization of Quassia undulata seed oil for ...

    African Journals Online (AJOL)

    dr eze


    Oct 16, 2012 ... This dependency on fossil fuel which is non-renewable has lead to increasing pollution and ... New oil seed crops are needed to meet existing energy demands (Gunstone, 1999) as such oils, mostly pro- ... with European organization (EN 14214). Refractive index (at room temperature), was determined ...

  4. Downstream processing and chromatography based analytical methods for production of vaccines, gene therapy vectors, and bacteriophages (United States)

    Kramberger, Petra; Urbas, Lidija; Štrancar, Aleš


    Downstream processing of nanoplexes (viruses, virus-like particles, bacteriophages) is characterized by complexity of the starting material, number of purification methods to choose from, regulations that are setting the frame for the final product and analytical methods for upstream and downstream monitoring. This review gives an overview on the nanoplex downstream challenges and chromatography based analytical methods for efficient monitoring of the nanoplex production. PMID:25751122

  5. The impact of Indonesian peatland degradation on downstream marine ecosystems and the global carbon cycle. (United States)

    Abrams, Jesse F; Hohn, Sönke; Rixen, Tim; Baum, Antje; Merico, Agostino


    Tropical peatlands are among the most space-efficient stores of carbon on Earth containing approximately 89 Gt C. Of this, 57 Gt (65%) are stored in Indonesian peatlands. Large-scale exploitation of land, including deforestation and drainage for the establishment of oil palm plantations, is changing the carbon balance of Indonesian peatlands, turning them from a natural sink to a source via outgassing of CO2 to the atmosphere and leakage of dissolved organic carbon (DOC) into the coastal ocean. The impacts of this perturbation to the coastal environment and at the global scale are largely unknown. Here, we evaluate the downstream effects of released Indonesian peat carbon on coastal ecosystems and on the global carbon cycle. We use a biogeochemical box model in combination with novel and literature observations to investigate the impact of different carbon emission scenarios on the combined ocean-atmosphere system. The release of all carbon stored in the Indonesian peat pool, considered as a worst-case scenario, will increase atmospheric pCO2 by 8 ppm to 15 ppm within the next 200 years. The expected impact on the Java Sea ecosystems is most significant on the short term (over a few hundred years) and is characterized by an increase of 3.3% in phytoplankton, 32% in seagrass biomass, and 5% decrease in coral biomass. On the long term, however, the coastal ecosystems will recover to reach near pre-excursion conditions. Our results suggest that the ultimate fate of the peat carbon is in the deep ocean with 69% of it landing in the deep DIC pool after 1000 years, but the effects on the global ocean carbonate chemistry will be marginal. © 2015 John Wiley & Sons Ltd.

  6. Assessing downstream flood impacts due to a potential GLOF from Imja Tsho in Nepal

    National Research Council Canada - National Science Library

    Somos-Valenzuela, M. A; McKinney, D. C; Byers, A. C; Rounce, D. R; Portocarrero, C; Lamsal, D


    Glacial-dominated areas pose unique challenges to downstream communities in adapting to recent and continuing global climate change, including increased threats of glacial lake outburst floods (GLOFs...

  7. A sustainability model based on cloud infrastructures for core and downstream Copernicus services (United States)

    Manunta, Michele; Calò, Fabiana; De Luca, Claudio; Elefante, Stefano; Farres, Jordi; Guzzetti, Fausto; Imperatore, Pasquale; Lanari, Riccardo; Lengert, Wolfgang; Zinno, Ivana; Casu, Francesco


    The incoming Sentinel missions have been designed to be the first remote sensing satellite system devoted to operational services. In particular, the Synthetic Aperture Radar (SAR) Sentinel-1 sensor, dedicated to globally acquire over land in the interferometric mode, guarantees an unprecedented capability to investigate and monitor the Earth surface deformations related to natural and man-made hazards. Thanks to the global coverage strategy and 12-day revisit time, jointly with the free and open access data policy, such a system will allow an extensive application of Differential Interferometric SAR (DInSAR) techniques. In such a framework, European Commission has been funding several projects through the GMES and Copernicus programs, aimed at preparing the user community to the operational and extensive use of Sentinel-1 products for risk mitigation and management purposes. Among them, the FP7-DORIS, an advanced GMES downstream service coordinated by Italian National Council of Research (CNR), is based on the fully exploitation of advanced DInSAR products in landslides and subsidence contexts. In particular, the DORIS project ( has developed innovative scientific techniques and methodologies to support Civil Protection Authorities (CPA) during the pre-event, event, and post-event phases of the risk management cycle. Nonetheless, the huge data stream expected from the Sentinel-1 satellite may jeopardize the effective use of such data in emergency response and security scenarios. This potential bottleneck can be properly overcome through the development of modern infrastructures, able to efficiently provide computing resources as well as advanced services for big data management, processing and dissemination. In this framework, CNR and ESA have tightened up a cooperation to foster the use of GRID and cloud computing platforms for remote sensing data processing, and to make available to a large audience advanced and innovative tools for DIn

  8. Identification of vegetable oil botanical speciation in refined vegetable oil blends using an innovative combination of chromatographic and spectroscopic techniques. (United States)

    Osorio, Maria Teresa; Haughey, Simon A; Elliott, Christopher T; Koidis, Anastasios


    European Regulation 1169/2011 requires producers of foods that contain refined vegetable oils to label the oil types. A novel rapid and staged methodology has been developed for the first time to identify common oil species in oil blends. The qualitative method consists of a combination of a Fourier Transform Infrared (FTIR) spectroscopy to profile the oils and fatty acid chromatographic analysis to confirm the composition of the oils when required. Calibration models and specific classification criteria were developed and all data were fused into a simple decision-making system. The single lab validation of the method demonstrated the very good performance (96% correct classification, 100% specificity, 4% false positive rate). Only a small fraction of the samples needed to be confirmed with the majority of oils identified rapidly using only the spectroscopic procedure. The results demonstrate the huge potential of the methodology for a wide range of oil authenticity work. Copyright © 2014 Elsevier Ltd. All rights reserved.

  9. Influence of top land deposits, fuel sulphur and lubricating oil viscosity on oil consumption and bore polishing in diesel engines

    Energy Technology Data Exchange (ETDEWEB)

    Raddatz, J.; McGeehan, J.A.


    The subject of this paper is the description of factors which cause high oil consumption and cylinder bore polishing. The investigation focused on top land deposits, the influence of fuel sulphur and the oil viscosity in a series of direct injection diesel engines of U.S. and European origin. In these diesel engine tests it was demonstrated that particularly excessive top land deposits cause high oil consumption and cylinder bore polishing. But cylinder bore polishing can also be caused by chemical corrosion when high sulphur fuels and oils of low alcalinity are used at the same time. In addition to the top land deposits and fuel sulphur factors, multigrade oils showed significant oil control advantages. The correlation between deposits and oil sulfated ash as well as between oil dispersant type and bore polishing is demonstrated and analyses of polished cylinder liners and piston deposits are presented.

  10. DORIS downstream service: a support to civil defence autorithies in landslides and subsidence risk management (United States)

    Ciampalini, A.; Del Ventisette, C.; Moretti, S.; Manunta, M.; Calò, F.; Paglia, L.; Ardizzone, F.; Guzzetti, F.; Rossi, M.; Bellotti, F.; Colombo, D.; Strozzi, T.; Wegmuller, U.; Mora, O.; Sanches, F.


    DORIS is an advanced FP7-EU project for the design of a pre-operational advanced downstream service aimed at detecting, mapping, monitoring and forecasting surface deformations, including landslides and ground subsidence, by exploiting multiple Earth Observation (EO) and ground-based (non-EO) data technologies. Ground deformations are the result of a variety of natural and human-induced causes and triggers. These phenomena are frequent and widespread in Europe, causing extensive economic damage to private properties and public assets and their social impact is relevant. In Europe, the large number of areas affected by ground deformations, the frequency and extent of the triggering events, the extent of the impact and the magnitude of the damage, make it mandatory a multiscale, systemic approach. Further, the complexity and extent of the problem is such that it cannot be tackled (and solved) at an individual, site-specific scale, or using a single technique or methodology. The problem can be approached only through the integration of data and information taken at different scales, and with the collaborative efforts of multiple expertise. With this respect, the several satellite sensors now available, including about forty passive - optical - sensors and nine active - synthetic aperture radar (SAR) - sensors, provide valuable technological alternatives to traditional methods and tools to detect, map, monitor and forecast ground deformations over large areas and with the required accuracy. The temporal continuity and the geometric compatibility among time series of ERS-1, ERS-2 and ENVISAT data represents an unprecedented opportunity to generate very long time series of ground deformations. This provides exclusive information for an improved understanding of the long term behavior of slow and very-slow ground deformation phenomena. In this context, DORIS intends to exploit the extensive catalogues of multiple C-band SAR sensors to provide, via a joint analysis

  11. DNA markers for Portuguese olive oil fingerprinting. (United States)

    Martins-Lopes, Paula; Gomes, Sónia; Santos, Elisabete; Guedes-Pinto, Henrique


    The certification of olive oil has led to the definition of Protected Denomination of Origin (PDO) producing regions in European countries. PDO products should be protected, and a solution could be by using DNA fingerprinting. In this work we evaluate the efficiency of RAPD, ISSR, and SSR molecular markers for olive oil varietal identification and their possible use in certification purposes. Twenty-three Portuguese olive oil samples (11 obtained monovarietal and 12 purchased commercial oils) were screened by means of two RAPD, four ISSR, and four SSR markers. The quality of amplified products was used to evaluate the reproducibility and the level of polymorphism. Principal component analysis was performed with DCENTER using unweighted pair group mathematical average (UPGMA) that allowed group formation according to olive oil varietal geographic origin.

  12. Educating in European Identity?

    National Research Council Canada - National Science Library

    Enrique Banús


    In the last decades, the claim for a "European identity" has been manifested sometimes as a solution for the citizens' distance to the European project, sometimes also as a precondition for a further...

  13. Extension of Oil Servicing Intervals for the Leopard AS-1 Power Pack (United States)


    two years when operating with a multigrade 15W40 oil (Nato 0-236). Results for 800 oil samples from more than 200 vehicles were summarized in Appendix 2.1.6 to Annexe A of reference 1. The multigrade oil used in the European study also remained satisfactory for continued operation after

  14. The strategy of players on the European gas market

    Energy Technology Data Exchange (ETDEWEB)

    Lecarpentier, A


    One result of opening up the European gas market to competition has been to increase the number and diversity of the players involved, whether producers, suppliers or electric utilities. However, while the gas on offer is still controlled by a handful of market players given the increasing importance of state-owned companies from exporting countries outside Europe, the downstream gas sector continues to show a strong concentration of incumbent operators seeking a dominant position in the supply of gas. (author)

  15. Transfer of sediment-associated metals downstream of abandoned and active mining sites in the Quesnel River catchment, British Columbia

    NARCIS (Netherlands)

    Perk, M. van der; Lipzig, M.L.H.M. van; Karimlou, G.; Owens, P.N.; Petticrew, E.L.


    Metal mining may have considerable impact on downstream water and sediment composition. The rate and extent that metals move downstream determine the magnitude and time scale of downstream sediment contamination. Conversely, the downstream metal content of sediments provide important clues of

  16. Principle and design of hatch operation system for fish migrating upstream-downstream of the discharge sill

    Directory of Open Access Journals (Sweden)

    Răzvan G.Voicu


    Full Text Available To improve fish migration and restore local lotic ecosystems, it is necessary to consider the various current hydro-construction methods. There have been partial successes in systems that improve fish passage over various obstacles but new approaches that present more efficient solutions and international collaboration among specialists are required. This article deals with European themes of great interest; issues related to interruption of longitudinal connectivity in heavily modified water courses, and improving the ecological status of damaged lotic systems, with the goal of achieving the environmental objectives set forth by the Water Framework Directive 2000/60/EC (WFD and the national legislative framework regarding water policy (which reflects the European directives Water Law no. 107, with subsequent amendments, NT No. / 2006 OM 1163/2007, and discusses the obligation to ensure that construction works protect fish migration to maintain ecological balance in the reservoirs. It is possible to use this system in almost any fish-bearing stream, both upstream and downstream of maximum circulation, which makes the system an excellent solution for assisting and improving migration.

  17. Heavy oil processing impacts refinery and effluent treatment operations

    Energy Technology Data Exchange (ETDEWEB)

    Thornthwaite, P. [Nalco Champion, Northwich, Cheshire (United Kingdom)


    Heavy oils are becoming more common in Europe. The processing of heavier (opportunity or challenge) crudes, although financially attractive, introduce additional challenges to the refiner. These challenges are similar whether they come from imported crudes or in the future possibly from shale oils (tight oils). Without a strategy for understanding and mitigating the processing issues associated with these crudes, the profit potential may be eroded by decreased equipment reliability and run length. This paper focuses on the impacts at the desalter and how to manage them effectively while reducing the risks to downstream processes. Desalters have to deal with an increased viscosity, density (lower API gravity), higher solids loading, potential conductivity issues, and asphaltene stability concerns. All these factors can lead to operational problems impacting downstream of the desalter, both on the process and the water side. The other area of focus is the effluent from the desalter which can significantly impact waste water operations. This can take the form of increased oil under-carry, solids and other contaminants originating from the crudes. Nalco Champion has experience in working with these challenging crudes, not only, Azeri, Urals and African crudes, but also the Canadian oil sands, US Shale oil, heavy South American crudes and crudes containing metal naphthenates. Best practices will be shared and an outlook on the effects of Shale oil will be given. (orig.)

  18. The effect of downstream perforated blanket on the safety against piping in heading-up structures

    Directory of Open Access Journals (Sweden)

    Mona A. Hagras


    It was found that piping index (Pe is governed by perforation ration (PR, relative hole diameter (D/Lb, ratio of length of the blanket to length of the apron (Lb/La, head difference between upstream and downstream structure and the depth of downstream cutoff.

  19. Hydrodynamic properties and distribution of bait downstream of a zooplankton trap

    DEFF Research Database (Denmark)

    Selander, Erik; Heuschele, Jan; Larsson, Ann I.


    The flow regime around a chemically baited trap is crucial for the trapping process and distribution of bait downstream of traps. We measured the flow field downstream of a trap prototype in flume experiments and mapped the distribution of bait using laser induced fluorescence. The trap produced ...

  20. Europeanization and transnational states

    DEFF Research Database (Denmark)

    Jacobsson, Bengt; Lægreid, Per; Pedersen, Ove K.

    This work investigates what happens to an organized political unit when it becomes part of a larger entity and, in particular, how increased European integration and the tentative moves towards a transnational state will affect the European Union's nation state. Europeanization and the transforma......This work investigates what happens to an organized political unit when it becomes part of a larger entity and, in particular, how increased European integration and the tentative moves towards a transnational state will affect the European Union's nation state. Europeanization...... in central government agencies. It concludes that the consequences of Europeanization can be described as the growth of a transnational administration where identities as well as loyalties are created in processes that transcend the borders of states....

  1. Gas and oil towards Europe: infrastructures outlook. European governance and energy geopolitics - Tome 4; Gaz et petrole vers l'Europe: perspectives pour les infrastructures. Gouvernance europeenne et geopolitique de l'energie - Tome 4

    Energy Technology Data Exchange (ETDEWEB)

    Nies, S. [Institut francais des Relations internationales (IFRI), 75 - Paris (France)


    In a context of strong energy dependence, the safety of supplies and the reliability of infrastructures remain of prime importance. The Europe of 27 is looking for the proper balance between excessive dependence and beneficial interdependence. A real competitive bidding about the potential paths of the Russian and CIS gas towards western Europe is taking place. However, a given energy infrastructure can change the economic and cultural relations and the prices as well. Interpreting the energy diplomacy between political and economical stakes has become a hard task. The underlying logic of the impressive number of projects in progress is extremely complex as many projects are in competition and linked with each others (like the BTC - Bakou-Tbilissi-Ceyhan, the Transcaspian and the South Stream). This study aims at presenting a comprehensive overview of the existing and planned projects with the help of a table which includes the oil and gas pipelines and the methane gas terminals. This study includes the imports coming from the north (Norway, UK), from the south (Algeria) and above all from the east (Russia and CIS). It includes the layout and the potential flow rate of these infrastructures, their present day use and financial conditions of transport, the projects in progress or planned, their cost, financing and possible date of commissioning. Even if the study encompasses all infrastructures (including Norway, UK and North Africa), it stresses on those linking Europe to Russia and to the post-soviet area (Central Asia, Caspian Sea). (J.S.)

  2. Present status of Mexico's oil policy

    Energy Technology Data Exchange (ETDEWEB)

    Ueno, Hiromu


    Mexico's oil exploration began with an excavation by an American in 1869. Mexico nationalized the petroleum industry in 1938. The discovery of a large oil field has caused Mexico to become the world's number four oil producing country in 1982. Then, as oil prices fell, Mexican economy lost its propulsive force. This paper describes the past and present of Mexico's oil industry. Mexico's oil policy is characterized by strong nationalism, a resource conservation policy, relations with OPEC, export prices policy, detachment from dependence on the US, the Acuerdo de San Jose (San Jose Treaty), and entry into the downstream. Mexico and Japan complement each other. Mexico exports crude oil to Japan via two routes through the sole intermediary of a Japanese company for importing Mexican oil. At present, Mexico does not have active relations with Japan in terms of oil export. Now that the oil market is more favorable for buyers than sellers, Japan is requested to approach Mexico actively. (7 tabs, 2 photos)

  3. European Science Notes Information Bulletin Reports on Current European/ Middle Eastern Science (United States)


    ceramics for MHD sys- tent 119. Osservatorio Astrofisico Citta Universitaria 124. Commission of the European Communities (CEC) 95125 Catania Joint Research...Instituto de Acustica (CSIC) above) Centro de Fisica Aplicada Studies: catalytic materials and their characteriza- Serrano, 144, Madrid tion, oil recovery...Universidade de Lisboa Karlsplatz 13 nvr Centro de Fisica Nuclear 1040 Vienna 4 Av. Prof. Gamma Pinto, 2 At stria 1699 Lisboa Codcx Dr. W. Langauer (N

  4. Life Cycle Assessment for the Production of Oil Palm Seeds. (United States)

    Muhamad, Halimah; Ai, Tan Yew; Khairuddin, Nik Sasha Khatrina; Amiruddin, Mohd Din; May, Choo Yuen


    The oil palm seed production unit that generates germinated oil palm seeds is the first link in the palm oil supply chain, followed by the nursery to produce seedling, the plantation to produce fresh fruit bunches (FFB), the mill to produce crude palm oil (CPO) and palm kernel, the kernel crushers to produce crude palm kernel oil (CPKO), the refinery to produce refined palm oil (RPO) and finally the palm biodiesel plant to produce palm biodiesel. This assessment aims to investigate the life cycle assessment (LCA) of germinated oil palm seeds and the use of LCA to identify the stage/s in the production of germinated oil palm seeds that could contribute to the environmental load. The method for the life cycle impact assessment (LCIA) is modelled using SimaPro version 7, (System for Integrated environMental Assessment of PROducts), an internationally established tool used by LCA practitioners. This software contains European and US databases on a number of materials in addition to a variety of European- and US-developed impact assessment methodologies. LCA was successfully conducted for five seed production units and it was found that the environmental impact for the production of germinated oil palm was not significant. The characterised results of the LCIA for the production of 1000 germinated oil palm seeds showed that fossil fuel was the major impact category followed by respiratory inorganics and climate change.

  5. Olive oil production and soil and water conservation in southern Spain, in relation to EU subsidy policies

    NARCIS (Netherlands)

    Graaff, de J.; Eppink, L.A.A.J.


    The European Union spent about two billion ECU per year on subsidies for the olive oil sector, of which Spain received about 35%. For the rainfed areas in southern Spain the olive oil sector is crucial, and so are these subsidies. The European Commission has formulated two options to change the


    African Journals Online (AJOL)


    from waste marble. The barium enhanced waste m methods and showed high performance to methyl activity of the solid oxide catalyst resulted from th with high dispersion of .... RANSESTERIFICATION OF CRUDE JATROPHA OIL USING WASTE MARBLE CATALYST ..... methanol will interfere with the glycerin separation.

  7. Recent developments in microbial oils production: a possible alternative to vegetable oils for biodiesel without competition with human food?

    Directory of Open Access Journals (Sweden)

    Gwendoline Christophe


    Full Text Available Since centuries vegetable oils are consumed as human food but it also finds applications in biodiesel production which is attracting more attention. But due to being in competition with food it could not be sustainable and leads the need to search for alternative. Nowdays microbes-derived oils (single cell oils seem to be alternatives for biodiesel production due to their similar composition to that of vegetable oils. However, the cold flow properties of the biodiesel produced from microbial oils are unacceptable and have to be modified by an efficient transesterification. Glycerol which is by product of transesterification can be valorised into some more useful products so that it can also be utilised along with biodiesel to simplify the downstream processing. The review paper discusses about various potent microorganisms for biodiesel production, enzymes involved in the lipid accumulation, lipid quantification methods, catalysts used in transesterification (including enzymatic catalyst and valorisation of glycerol.

  8. Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters.

    Directory of Open Access Journals (Sweden)

    Christopher A Lavender


    Full Text Available Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene transcription starts sites in human breast cancer cells, investigating the genomic context of downstream antisense transcription. We find extensive correlations between antisense transcription and features associated with the chromatin environment at gene promoters. Antisense transcription downstream of promoters is widespread, with antisense transcription initiation observed within 2 kb of 28% of gene transcription start sites. Antisense transcription initiates between nucleosomes regularly positioned downstream of these promoters. The nucleosomes between gene and downstream antisense transcription start sites carry histone modifications associated with active promoters, such as H3K4me3 and H3K27ac. This region is bound by chromatin remodeling and histone modifying complexes including SWI/SNF subunits and HDACs, suggesting that antisense transcription or resulting RNA transcripts contribute to the creation and maintenance of a promoter-associated chromatin environment. Downstream antisense transcription overlays additional regulatory features, such as transcription factor binding, DNA accessibility, and the downstream edge of promoter-associated CpG islands. These features suggest an important role for antisense transcription in the regulation of gene expression and the maintenance of a promoter-associated chromatin environment.

  9. Downstream Antisense Transcription Predicts Genomic Features That Define the Specific Chromatin Environment at Mammalian Promoters. (United States)

    Lavender, Christopher A; Cannady, Kimberly R; Hoffman, Jackson A; Trotter, Kevin W; Gilchrist, Daniel A; Bennett, Brian D; Burkholder, Adam B; Burd, Craig J; Fargo, David C; Archer, Trevor K


    Antisense transcription is a prevalent feature at mammalian promoters. Previous studies have primarily focused on antisense transcription initiating upstream of genes. Here, we characterize promoter-proximal antisense transcription downstream of gene transcription starts sites in human breast cancer cells, investigating the genomic context of downstream antisense transcription. We find extensive correlations between antisense transcription and features associated with the chromatin environment at gene promoters. Antisense transcription downstream of promoters is widespread, with antisense transcription initiation observed within 2 kb of 28% of gene transcription start sites. Antisense transcription initiates between nucleosomes regularly positioned downstream of these promoters. The nucleosomes between gene and downstream antisense transcription start sites carry histone modifications associated with active promoters, such as H3K4me3 and H3K27ac. This region is bound by chromatin remodeling and histone modifying complexes including SWI/SNF subunits and HDACs, suggesting that antisense transcription or resulting RNA transcripts contribute to the creation and maintenance of a promoter-associated chromatin environment. Downstream antisense transcription overlays additional regulatory features, such as transcription factor binding, DNA accessibility, and the downstream edge of promoter-associated CpG islands. These features suggest an important role for antisense transcription in the regulation of gene expression and the maintenance of a promoter-associated chromatin environment.

  10. Stromal Progesterone Receptors Mediate Induction of Indian Hedgehog (IHH) in Uterine Epithelium and Its Downstream Targets in Uterine Stroma (United States)

    Simon, Liz; Spiewak, Kerry A.; Ekman, Gail C.; Kim, Jaeyeon; Lydon, John P.; Bagchi, Milan K.; Bagchi, Indrani C.; DeMayo, Francesco J.; Cooke, Paul S.


    Uterine receptivity to embryo implantation depends on appropriate progesterone (P4) and estrogen stimulation. P4 rapidly stimulates production of the morphogen Indian hedgehog (IHH) in murine uterine epithelium as well as downstream molecules in the hedgehog pathway such as Patched homolog 1 (PTCH1) and nuclear receptor subfamily 2, group F, member 2 (NR2F2) in uterine stroma. Studies using IHH-null mice indicate that IHH is obligatory for the normal P4 response in the uterus. To determine whether IHH induction in uterine epithelium is mediated through P4 receptor (PR) in epithelium (E) and/or stroma (S), we produced tissue recombinants using uteri from neonatal PR knockout (ko) mice and wild-type (wt) mice containing PR in S and/or E or lacking PR altogether using a tissue recombinant methodology and assessed their response to P4. In tissue recombinants containing wt-S (wt-S + wt-E and wt-S + ko-E), P4 induced Ihh mRNA expression at 6 h that was 6-fold greater than in oil-treated controls (P < 0.05; n = 6) in both types of tissue recombinants despite the absence of epithelial PR in wt-S + ko-E grafts. Conversely, Ihh mRNA expression was unaffected by P4 in ko-S + ko-E and ko-S + wt-E grafts despite epithelial PR expression in the latter. Nr2f2 and Ptch1 mRNA expression was similar in that it was stimulated by P4 only in recombinants containing stromal PR. These results indicate that stromal PR is both necessary and sufficient for P4 stimulation of epithelial IHH as well as downstream events such as PTCH1 and NR2F2 increases in stroma. PMID:19372202

  11. Coupling of downstream RNA polymerase-promoter interactions with formation of catalytically competent transcription initiation complex. (United States)

    Mekler, Vladimir; Minakhin, Leonid; Borukhov, Sergei; Mustaev, Arkady; Severinov, Konstantin


    Bacterial RNA polymerase (RNAP) makes extensive contacts with duplex DNA downstream of the transcription bubble in initiation and elongation complexes. We investigated the role of downstream interactions in formation of catalytically competent transcription initiation complex by measuring initiation activity of stable RNAP complexes with model promoter DNA fragments whose downstream ends extend from +3 to +21 relative to the transcription start site at +1. We found that DNA downstream of position +6 does not play a significant role in transcription initiation when RNAP-promoter interactions upstream of the transcription start site are strong and promoter melting region is AT rich. Further shortening of downstream DNA dramatically reduces efficiency of transcription initiation. The boundary of minimal downstream DNA duplex needed for efficient transcription initiation shifted further away from the catalytic center upon increasing the GC content of promoter melting region or in the presence of bacterial stringent response regulators DksA and ppGpp. These results indicate that the strength of RNAP-downstream DNA interactions has to reach a certain threshold to retain the catalytically competent conformation of the initiation complex and that establishment of contacts between RNAP and downstream DNA can be coupled with promoter melting. The data further suggest that RNAP interactions with DNA immediately downstream of the transcription bubble are particularly important for initiation of transcription. We hypothesize that these active center-proximal contacts stabilize the DNA template strand in the active center cleft and/or position the RNAP clamp domain to allow RNA synthesis. Copyright © 2014 Elsevier Ltd. All rights reserved.

  12. Greenhouse gases in natural gas and oil production and electricity generation

    Energy Technology Data Exchange (ETDEWEB)

    Kaarstad, O. (Statoil R and D Centre, Trondheim (Norway))


    As a major European player in production, transportation and downstream processing and utilization of oil and natural gas. Statoil is very much aware of the greenhouse gas questions and their actual and possible future effects on the energy market. Norway, the main operational area, provides part of the motivation for being conscious with respect to greenhouse gases through a 50 US dollar/ton CO[sub 2] tax for offshore activities. For natural gas, oil and coal, the question of emissions of the greenhouse gas methane during production, transportation, storage and use is an important issue. The paper outlines activities and preliminary results for natural gas and oil chains and also how these methane emissions may be reduced. Statoil will reduce the CO[sub 2]-emissions from existing offshore installations by 25% and from future installations by 40% through various conventional and unconventional means. One unconventional angle of approach is that the owners of the Statoil operated Sleipner Vest gas/condensate field, where the natural gas in the reservoir contains 7-9% CO[sub 2], have proposed to the authorities to reinject the CO[sub 2] recovered from the natural gas into an aquifer above the gas reservoir itself. A similar scheme is also being studied for the CO[sub 2] from the CO[sub 2]-rich gas from the Snohvit gas field off Northern Norway. As an insurance for fossil fuels against a possible greenhouse-driven future, Statoil is actively pursuing research and development in the area of CO[sub 2]-removal from large point sources like gas fired power plants and sequestration of the CO[sub 2] into empty oil and gas reservoirs, in aquifers and in the ocean. The preliminary costs of applying such methods are discussed and compared with carbon taxes and other options for limiting CO[sub 2] build-up in the atmosphere. In addition the possibility of using captured CO[sub 2] for enhanced oil recovery (EOR) will be discussed briefly. 4 figs, 4 tabs.

  13. Measurement of velocity deficit at the downstream of a 1:10 axial hydrokinetic turbine model

    Energy Technology Data Exchange (ETDEWEB)

    Gunawan, Budi [ORNL; Neary, Vincent S [ORNL; Hill, Craig [St. Anthony Falls Laboratory, 2 Third Avenue SE, Minneapolis, MN 55414; Chamorro, Leonardo [St. Anthony Falls Laboratory, 2 Third Avenue SE, Minneapolis, MN 55414


    Wake recovery constrains the downstream spacing and density of turbines that can be deployed in turbine farms and limits the amount of energy that can be produced at a hydrokinetic energy site. This study investigates the wake recovery at the downstream of a 1:10 axial flow turbine model using a pulse-to-pulse coherent Acoustic Doppler Profiler (ADP). In addition, turbine inflow and outflow velocities were measured for calculating the thrust on the turbine. The result shows that the depth-averaged longitudinal velocity recovers to 97% of the inflow velocity at 35 turbine diameter (D) downstream of the turbine.

  14. Is the western population of the European mink, (Mustela lutreola), a distinct Management Unit for conservation?


    Michaux, Johan; Libois, Roland; Davison, A; Chevret, P; Rosoux, R.


    The European mink (Mustela lutreola) is one of the most threatened carnivores in Europe, with fragmented populations in Belarus. Russia and Romania, as well in south-western France and northern Spain. Many populations have become extinct recently, or are declining. We investigated mitochondrial DNA variation, using the complete D-loop region, and concentrating oil the west European population. The aim was two-fold: to use the genetic information to advise on the conservation of European mink,...

  15. Pumped : everyone's guide to the oil patch

    Energy Technology Data Exchange (ETDEWEB)

    Finch, D.


    This books remarked on several issues regarding oil and gas, such as who controls oil and gas in Canada and why it costs so much. It explained where oil comes from, how it got there, why it is trapped in the earth and how it was discovered. It also explained why oil and gas has taken over as the fuel of choice for many modern societies. The book clarified why the petroleum industry dominates world economics and political arenas. Seven examples of Canadian National Energy Programs were also presented. The author provided a historical context of all areas of the Canadian oil patch, including exploration crews at the Geological Survey, Hibernia east-coast offshore drilling technology, the controversial Mackenzie pipeline and Alberta's oil sands. The issue of remaining oil reserves was also discussed along with the current state of the tar sands. The book included illustrations, maps, photographs and a user friendly index-glossary to explain basic terms used in the oil patch, such as the differentiation between the upstream, midstream and downstream industry. The author emphasized the importance of being well informed as a consumer in order to form knowledgeable opinions about how the Canadian oil patch is developed. tabs., figs.

  16. Evaluation of a Solid Phase DNA Binding Matrix for Downstream PCR Analysis

    National Research Council Canada - National Science Library

    Bader, Douglas E; Fisher, Glen R; Stratilo, Chad W


    A commercially available solid-phase DNA binding matrix (FTA cards) was evaluated for its ability to capture and release DNA for downstream gene amplification and detection assays using polymerase chain reaction (PCR...

  17. Modeling of local scour depth downstream hydraulic structures in trapezoidal channel using GEP and ANNs

    Directory of Open Access Journals (Sweden)

    Yasser Abdallah Mohamed Moussa


    Full Text Available Local scour downstream stilling basins is so complex that it makes it difficult to establish a general empirical model to provide accurate estimation for scour depth. Lack estimation of local scour can endanger to stability of hydraulic structure and can cause risk of failure. This paper presents Gene expression program (GEP and artificial neural network (ANNs, to simulate local scour depth downstream hydraulic structures. The experimental data is collected from the literature for the scour depth downstream the stilling basin through a trapezoidal channel. Using GEP approach gives satisfactory results compared with artificial neural network (ANN and multiple linear regression (MLR modeling in predicting the scour depth downstream of hydraulic structures.

  18. Wavelength remodulation scheme using DPSK downstream and upstream for DWDM-PONs. (United States)

    Deb, Nebras; Anis, Hanan


    We propose a novel wavelength-division-multiplexed passive optical network (WDM-PON) architecture with enhanced tolerance toward chromatic dispersion where a DPSK-modulated downstream signal with constant intensity is remodulated at the ONU side with a return to zero (RZ-DPSK). Driving the downstream modulator with a 50% RZ data enabled us to employ the pulse carver at the ONU for both removing downstream data and generating the optical RZ signal for upstream. This offers an attractive alternative to earlier proposed schemes as it allows us to use full modulation depth (FMD) and balanced detection for downstream data restoration. We experimentally demonstrate the system with both balanced and single-ended detection at 2.5 Gb/s. Error-free operation has been achieved along a 20 Km single mode fiber without dispersion compensation. © 2011 Optical Society of America

  19. The dynamics of entrepreneurship in ICT: case of mobile phones downstream services in Kenya

    NARCIS (Netherlands)

    R.N. Kanothi (Raphael)


    textabstractThe research paper explores the extent to which mobile phones downstream services, defined here as those provided using the existing connectivity, are generating opportunities for entrepreneurship development in Kenya. After identifying the services of mobile payphones, money transfer


    Directory of Open Access Journals (Sweden)

    Ignat Ion


    Full Text Available The construction of European Monetary Union has raised several questions about the existence of a common business cycle, a European one. The lack of cyclical synchronization would complicate the monetary and fiscal policies in the Union, being a negative

  1. European Home Energy

    DEFF Research Database (Denmark)

    Tommerup, Henrik M.


    An important aim of the european energy performance of buildings directive is to improve the overall energy efficiency of new homes......An important aim of the european energy performance of buildings directive is to improve the overall energy efficiency of new homes...

  2. European Industry, 1700 - 1870

    NARCIS (Netherlands)

    Broadberry, Stephen; Fremdling, Rainer; Solar, Peter M.


    This paper offers an overview of the development of European industry between 1700 and 1870, drawing in particular on the recent literature that has emerged following the formation of the European Historical Economics Society in 1991. The approach thus makes use of economic analysis and quantitative

  3. The European Programme Manager

    DEFF Research Database (Denmark)

    Larson, Anne; Bergman, E.; Ehlers, S.

    The publication is a result of a cooperation between organisations in six European countries with the aim to develop a common European education for programme managers. It contains of a description of the different elements of the education together with a number of case-studies from the counties...

  4. European works councils

    DEFF Research Database (Denmark)

    Knudsen, Herman Lyhne


    The theme adressed by this paper is the opportunities for European Works Councils (EWCs) of gaining influence on corporate decisions in multinational companies.......The theme adressed by this paper is the opportunities for European Works Councils (EWCs) of gaining influence on corporate decisions in multinational companies....

  5. European works councils

    DEFF Research Database (Denmark)

    Knudsen, Herman Lyhne


    The theme addressed by this artcle is the opportunities for European Works Councils of gaining influence on corporate decisions in multinational companies.......The theme addressed by this artcle is the opportunities for European Works Councils of gaining influence on corporate decisions in multinational companies....

  6. Introduction: European climate leadership

    NARCIS (Netherlands)

    Wurzel, R.K.W.; Liefferink, J.D.; Connelly, J.


    There is no shortage of would-be leaders in EU climate change politics. The EU institutions (e.g. European Council, Council of the EU, Commission and the European Parliament (EP)), member states and societal actors have all, though to varying degrees and at different time periods, tried to offer

  7. Europeanization : A Poststructuralist Approach

    NARCIS (Netherlands)

    Neuman-Stanivukovic, Senka


    This dissertation begins from the hypothesis that the direction and extent of Europeanization depends on domestic perception of the European Union and its norms. Accordingly, it was my empirical ambition to study how competing articulations of the EU and its norms constructed debates in EU member

  8. European media law

    NARCIS (Netherlands)

    Castendyk, O.; Dommering, E.; Scheuer, A.


    European Union legislation concerning electronic communications media is firmly established as an essential part of the law in the field in Europe. From relevant provisions of the European Convention of Human Rights and the EC Treaty to numerous directives, the most recent being the Audiovisual

  9. Bioactive Carbohydrates and Peptides in Foods: An Overview of Sources, Downstream Processing Steps and Associated Bioactivities. (United States)

    Hayes, Maria; Tiwari, Brijesh K


    Bioactive peptides and carbohydrates are sourced from a myriad of plant, animal and insects and have huge potential for use as food ingredients and pharmaceuticals. However, downstream processing bottlenecks hinder the potential use of these natural bioactive compounds and add cost to production processes. This review discusses the health benefits and bioactivities associated with peptides and carbohydrates of natural origin and downstream processing methodologies and novel processes which may be used to overcome these.

  10. Understanding the expansion of energy crops beyond the global biofuel boom : evidence from oil palm expansion in Colombia

    NARCIS (Netherlands)

    Marin-Burgos, Victoria; Clancy, Joy S.


    Background: The global palm oil market experienced a remarkable boom since the year 2000. Since palm oil can be used for biodiesel production, the global expansion of oil palm cultivation has been associated with the global biofuel boom. Biofuel policies—especially those adopted in the European

  11. The Biodiversity Changes in the Microbial Population of Soils Contaminated with Crude Oil. (United States)

    Abbasian, Firouz; Lockington, Robin; Megharaj, Mallavarapu; Naidu, Ravi


    Crude oil spills resulting from excavation, transportation and downstream processes can cause intensive damage to living organisms and result in changes in the microbial population of that environment. In this study, we used a pyrosequencing analysis to investigate changes in the microbial population of soils contaminated with crude oil. Crude oil contamination in soil resulted in the creation of a more homogenous population of microorganisms dominated by members of the Actinomycetales, Clostridiales and Bacillales (all belonging to Gram-positive bacteria) as well as Flavobacteriales, Pseudomonadales, Burkholderiales, Rhizobiales and Sphingomonadales (all belonging to Gram-negative bacteria). These changes in the biodiversity decreased the ratios of chemoheterotrophic bacteria at higher concentrations of crude oil contamination, with these being replaced by photoheterotrophic bacteria, mainly Rhodospirillales. Several of the dominant microbial orders in the crude oil contaminated soils are able to degrade crude oil hydrocarbons and therefore are potentially useful for remediation of crude oil in contaminated sites.

  12. Efficacy of Olive oil, Groundnut oil, Soybean oil and Palm kernel oil ...

    African Journals Online (AJOL)

    Laboratory experiments were conducted to investigate the potentials of four different vegetable oils (olive oil, groundnut oil, soybean oil and palm kernel oil) for the protection of stored cowpea against Callosobruchus maculatus. Ife-brown seeds (a susceptible variety) used for the experiment were subjected to the different ...

  13. Ecological taxes in some European countries

    Directory of Open Access Journals (Sweden)

    Filipović Sanja


    Full Text Available Production and consumption of fossil fuels is one of the major causes of the green house effect, which is in economics known as a form of ecological externality. Fiscal solution, as one way of internalization of externalities, is based on polluters-pay principle and the imposition of tax on emission. Although the implementation of ecological tax was intensified during the previous decade, fiscal revenues are modest and account for only 5% of the total fiscal revenues of the European Union. Taxes on energetic products, accounting for 76%, are dominant among ecological taxes. Since the EU Directive 82/92 imposes minimum excise rates on oil products, during the last decade Central Eastern European countries have increased excise rates on fossil fuels and fully engaged in the field of ecological policy.

  14. Olive oil and haemostasis

    Directory of Open Access Journals (Sweden)

    Williams, Christine M.


    Full Text Available Olive oil is a key component of the traditional Mediterranean diet; a diet that may explain the low rate of cardiovascular disease (CVD in Southern European. (Extra virgin Olive oil is a good source of monounsaturated fatty acids (MUFA and phenolic compounds, both of which have been investigated for their effects on plasma lipids and lipoproteins, measures of oxidation and factors related to thrombosis. This issue aims to summarise the current understanding of the effects of such dietary components on the haemostatic system and subsequent risk of CVD. To date, evidence suggests that diets rich in MUFA and thus in olive oil attenuate the thrombotic response via a reduction in platelet aggregation and in postprandial FVII levels. Thrombosis is a key event in causing heart attacks and strokes, which if modulated by diet could pose a cost-effective way of reducing CVD incidence in populations that adhere to MUFA/olive oil-rich diets long-term.El aceite de oliva es un componente esencial de la dieta Mediterránea que puede explicar el bajo índice de enfermedad cardiovascular (CVD en los países del sur de Europa. El aceite de oliva (extra virgen es una fuente de ácidos grasos monoinsaturados (MUFA y de compuestos fenólicos, de gran interés por sus efectos, entre otros, sobre las lipoproteínas y los lípidos plasmáticos, su capacidad antioxidante y su papel en la expresión de factores relacionados con la trombosis. En este capítulo se presenta un resumen del conocimiento actual sobre la influencia derivada del consumo de aceite de oliva (extra virgen en el sistema hemostático y el riesgo de CVD. Por ahora se sabe que dietas ricas en MUFA (aceite de oliva pueden atenuar la respuesta trombótica mediante la reducción de la agregación plaquetaria y de las concentraciones postprandiales del factor VII de coagulación (FVII. La trombosis es un evento relevante en los ataques al corazón y el ictus, de manera que su modulación con la dieta puede

  15. 77 FR 74985 - Water Quality Standards for the State of Florida's Streams and Downstream Protection Values for... (United States)


    ... Downstream Protection Values for Lakes: Remanded Provisions AGENCY: Environmental Protection Agency (EPA... cannot be performed to derive downstream protection values (DPVs) that will ensure the attainment and... lakes, springs, flowing waters, estuaries, and coastal waters, as well as downstream protection values...

  16. Prospects for European labour demand. (United States)

    Lindley, R M


    The impact of economic and technological trends upon the level and structure of labor demand is examined, exploring the methods used to model the labor market and making special reference to demography and technology. Evidence on recent and prospective changes in labor demand is reviewed for France, Germany, Italy, the Netherlands, and the UK. The models used to explore future employment scenarios usually fail to incorporate the linkages required to fully analyze the various demographic-economic interactions. Further, this is not generally viewed as a limitation, given the time frame of most employment projections and their preoccupation with changes in the structure of labor demand. Medium-term multisectoral models tend to pay more attention to both demographic and technical change, but the treatment of both aspects is limited. The projections provide a framework for considering how both socioeconomic behavior and policy might change to achieve different outcomes. The greater a model's behavioral content, as expressed in its relationships between different variables, the greater the insight obtainable from simulation exercises. The 1st half of the 1970s was characterized by a reduction in German employment, representing the severest of European reactions to the oil crisis. The 2nd half of the decade recorded rapid growth in Italy and the Netherlands. The 1980s started with marked declines in Germany and the UK. Overall, the net gains of the 1970s were lost in the recession following the 2nd oil crisis. In none of the 5 countries studied does any realistic prospect emerge of achieving full employment before 2000. The most optimistic outcome is that unemployment will decline only slowly, it at all. The growth of both new forms and areas of employment will not compensate sufficiently for the loss of jobs elsewhere and the growth of labor supply. The industrial sector will continue to experience change in favor of the service sector but at a slower rate than during

  17. Cedar leaf oil poisoning (United States)

    Cedar leaf oil is made from some types of cedar trees. Cedar leaf oil poisoning occurs when someone swallows this substance. ... The substance in cedar leaf oil that can be harmful is thujone (a hydrocarbon).

  18. Update of European bioethics

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl


    , the principles of autonomy, dignity, integrity and vulnerability are proposed as the most important ethical principles for respect for the human person in biomedical and biotechnological development. This approach to bioethics and biolaw is presented here in a short updated version that integrates the earlier......This paper presents an update of the research on European bioethics undertaken by the author together with Professor Peter Kemp since the 1990s, on Basic ethical principles in European bioethics and biolaw. In this European approach to basic ethical principles in bioethics and biolaw...... research in a presentation of the present understanding of the basic ethical principles in bioethics and biolaw....

  19. Democratic Citizenship: European referents

    Directory of Open Access Journals (Sweden)



    Full Text Available Let’s sense beforehand in this article a tour concerning the educational European policies that favors the development of a democratic citizenship. The aim that we chase is to understand the way in which nowadays it is being interpreted and stimulated the Citizenship education from European Union. for it we offer a conceptual delimiting of «Citizenship education» and later, we show an analysis of the principal documents and materials elaborated principally by the Council of Europe that mark the way followed by European Union as for education for Democratic Citizenship (EDC.

  20. Water quality of the Atibaia River, the upstream and downstream of the REPLAN/PETROBRAS Refinery; Qualidade da agua do Rio Atibaia a jusante e a montante da Refinaria REPLAN/PETROBRAS

    Energy Technology Data Exchange (ETDEWEB)

    Wieczorek, A.; Angelis, D.F.; Kataoka, A.P.A.G.; Coneglian, C.M.R.; Oliveira, V.J.A. [UNESP, Rio Claro, SP (Brazil). Inst. de Geociencias e Ciencias Exatas. Dept. de Bioquimica e Microbiologia]. E-mail:;


    Oil refineries use a large amount of water in the oil refinement process everyday, which results in complex mixtures of chemistry substances effectively pollutant to fresh water. This investigation evaluates the water quality of Atibaia river, the upstream and downstream of REPLAN/PETROBRAS oil refinery. Water samples were collected every two weeks between July and December, 2001. The most important physical, chemical and toxicological parameters were studied, besides the water quality index. The results demonstrated that, in some samplings, the refinery wastewater modified parameters like: chlorides, biochemical oxygen demand (BOD), and water electrical conductivity of the Atibaia river. This change was mainly observed during months of less rainfall, consequently bringing a decrease in the stream flow rate and in the river ability of self purification. (author)

  1. Oil spill contamination probability in the southeastern Levantine basin. (United States)

    Goldman, Ron; Biton, Eli; Brokovich, Eran; Kark, Salit; Levin, Noam


    Recent gas discoveries in the eastern Mediterranean Sea led to multiple operations with substantial economic interest, and with them there is a risk of oil spills and their potential environmental impacts. To examine the potential spatial distribution of this threat, we created seasonal maps of the probability of oil spill pollution reaching an area in the Israeli coastal and exclusive economic zones, given knowledge of its initial sources. We performed simulations of virtual oil spills using realistic atmospheric and oceanic conditions. The resulting maps show dominance of the alongshore northerly current, which causes the high probability areas to be stretched parallel to the coast, increasing contamination probability downstream of source points. The seasonal westerly wind forcing determines how wide the high probability areas are, and may also restrict these to a small coastal region near source points. Seasonal variability in probability distribution, oil state, and pollution time is also discussed. Copyright © 2014 Elsevier Ltd. All rights reserved.

  2. Freezing fecal samples prior to DNA extraction affects the Firmicutes to Bacteroidetes ratio determined by downstream quantitative PCR analysis. (United States)

    Bahl, Martin Iain; Bergström, Anders; Licht, Tine Rask


    Freezing stool samples prior to DNA extraction and downstream analysis is widely used in metagenomic studies of the human microbiota but may affect the inferred community composition. In this study, DNA was extracted either directly or following freeze storage of three homogenized human fecal samples using three different extraction methods. No consistent differences were observed in DNA yields between extractions on fresh and frozen samples; however, differences were observed between extraction methods. Quantitative PCR analysis was subsequently performed on all DNA samples using six different primer pairs targeting 16S rRNA genes of significant bacterial groups, and the community composition was evaluated by comparing specific ratios of the calculated abundances. In seven of nine cases, the Firmicutes to Bacteroidetes 16S rRNA gene ratio was significantly higher in fecal samples that had been frozen compared to identical samples that had not. This effect was further supported by qPCR analysis of bacterial groups within these two phyla. The results demonstrate that storage conditions of fecal samples may adversely affect the determined Firmicutes to Bacteroidetes ratio, which is a frequently used biomarker in gut microbiology. © 2012 Federation of European Microbiological Societies. Published by Blackwell Publishing Ltd. All rights reserved.

  3. Medium-Term Oil Market Report (MTOMR) 2008

    Energy Technology Data Exchange (ETDEWEB)



    Why have oil prices hit US$140 per barrel? How strong will oil demand be in the upcoming years? Will supply of crude oil, natural gas liquids and biofuels be sufficient to meet this future demand? And, no less crucially, what investments in refining capacity and technology can we expect and will these help ease some of the imbalance in strained oil product markets? The Medium-Term Oil Market Report (now in its third year) published by the International Energy Agency (IEA) has become a new benchmark, complementing the short-term market analysis provided in the IEA Oil Market Report. This year's edition reappraises all upstream and downstream projects worldwide, setting them against a revised demand forecast and expanding the time horizon to 2013. Special features this year include in-depth analyses of price formation, transport trends, non-OECD economies, non-OPEC production decline, project slippage, key crude export pipeline developments and a stronger emphasis on product supply bottlenecks. An essential report for all policy makers, market analysts, energy experts and anyone interested in understanding and following oil market trends, the Medium-Term Oil Market Report is a further element of the strong commitment of the IEA to improving and expanding the quality, timeliness and accuracy of energy data and analysis.


    Directory of Open Access Journals (Sweden)

    Adam Przybyłowski


    Full Text Available In the contemporary world, despite the growing importance and scale of the use of renewable energy , conventional energy resources still play a huge role. The European Union countries are dependent on the oil imports and the their main supplier of crude oil and natural gas has been the Russian Federation. After the collapse of the Soviet Union , the Caspian Sea region has become an alternative to Russian energy resources. The Unit-ed States , European Union, China and many other countries have shown their interest about this region. Despite a relatively large oil and natural gas reserves, the export of the-se commodities to the West is still problematic. Based on the available data and infor-mation, the publication explores the issue of energy resources transport directions with a particular emphasis on the crude oil from the Caspian Sea region to Europe.

  5. CERN welcomes European science

    CERN Multimedia


    On 3 and 4 October CERN will host a special workshop for Marie Curie fellows. This programme is a key plank in the EU's strategy for creating a European research area.     With thousands of scientists from all over the continent working together, CERN is already an exemplary European science showcase. On 3 and 4 October, the Laboratory will contribute further to unifying all European science by hosting a special workshop for EU-funded Marie Curie fellows. This scheme gives young researchers from around the continent the mobility to go to wherever Europe's best facilities in their chosen field happen to be. The event that will take place at CERN, entitled 'Special workshop of Marie Curie Fellows on research and training in physics and technology', organised together with the European Commission, is a continuation of a series of workshops with the aim, among others, of promoting young researchers, supporting their training and mobility, and facilitating the interdisciplinary dissemination of knowledge. Dur...

  6. European Economic Integration (United States)

    Huston, James A.


    Recounts the history and problems of European Economic Integration from the first post World War II organization, the OEEC, to the EEC (Common Market) and the EFTA. Suggestions for further reading are included. (JB)

  7. European Molecular Biology Laboratory

    CERN Multimedia


    On 10 May an Agreement was signed at CERN setting up a new European Laboratory. It will be concerned with research in molecularbiology and will be located at Heidelberg in the Federal Republic of Germany.

  8. The European University Landscape

    DEFF Research Database (Denmark)

    Daraio, Cinzia; Bonaccorsi, Andrea; Geuna, Aldo


    This paper provides a new and systematic characterization of 488 universities, from 11 European countries: Finland, France, Germany, Hungary, Italy, Netherlands, Norway, Portugal, Spain, Switzerland and UK. Using micro indicators built on the integrated Aquameth database, we characterize the Euro...

  9. European mobility cultures

    DEFF Research Database (Denmark)

    Haustein, Sonja; Nielsen, Thomas A. Sick


    More targeted European policies promoting green travel patterns require better knowledge on differing mobility cultures across European regions. As a basis for this, we clustered the EU population into eight mobility styles based on Eurobarometer data. The mobility styles - including, for example......-economic resources. In a second step, the 28 EU member countries were clustered into six country clusters based on their representation of mobility styles. The country clusters indicate the existence of considerably different mobility cultures across the EU. Sub-regions can be identified that have highly different...... positions on the path towards sustainable mobility and therefore different requirements towards European platforms and support measures, e.g. for 'Sustainable Urban Mobility Plans'. The country clusters can provide a starting point for future communication and targeting of European efforts in sustainable...

  10. Diversification of Oil and Gas Companies’ Activities in the Condition of Oil Prices Reduction and Economic Sanctions

    Directory of Open Access Journals (Sweden)

    Anastasia V. Sheveleva


    Full Text Available This article analyzes the influence of the economic sanctions imposed from the USA and the EU and oil prices reduction on the oil and gas companies and the directions of diversification of their activity as a method of management of price risks are considered. In the modern dynamic and quickly developing world, in the conditions of globalization and market economy, the oil and gas companies are affected by various risks which can exert negative impact on production and financial results. Risks can arise in absolutely various spheres, beginning from natural and technological hazards, and finishing with price risks. Sharp reduction of oil prices and decrease in demand for energy resources in the world markets, first of all in the European countries, input of financial or technological sanctions from the USA and Europe against Russia in 2014 has caused necessity of search a new more effective methods of price risks management of the oil and gas company. The methods of price risk management include the creation of commodity reserves, the establishment of a reserve fund, long-term contracts, subsidies from the state and the diversification of activities. The most effective it is possible to offer diversification of oil and gas companies' activity. It is expedient to carry out diversification of oil and gas companies' activity in such directions as geographical diversification of the oil, oil products and gas realization directions, geographical diversification of oil and gas companies' purchasing activity, diversification of oil, oil products and gas transportation ways, diversification of oil and gas companies' business. This approach allows to expand the activities of the oil and gas companies and create additional ways to generate revenue and enhance efficiency of oil and gas companies.

  11. Downstream Intensification Effects Associated with CO2 Laser Mitigation of Fused Silica

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, M J; Bass, I L; Guss, G M; Widmayer, C C; Ravizza, F L


    Mitigation of 351nm laser-induced damage sites on fused silica exit surfaces by selective CO{sub 2} treatment has been shown to effectively arrest the exponential growth responsible for limiting the lifetime of optics in high-fluence laser systems. However, the perturbation to the optical surface profile following the mitigation process introduces phase contrast to the beam, causing some amount of downstream intensification with the potential to damage downstream optics. Control of the laser treatment process and measurement of the associated phase modulation is essential to preventing downstream 'fratricide' in damage-mitigated optical systems. In this work we present measurements of the surface morphology, intensification patterns and damage associated with various CO{sub 2} mitigation treatments on fused silica surfaces. Specifically, two components of intensification pattern, one on-axis and another off-axis can lead to damage of downstream optics and are related to rims around the ablation pit left from the mitigation process. It is shown that control of the rim structure around the edge of typical mitigation sites is crucial in preventing damage to downstream optics.

  12. Measurement of the airflow velocity upstream and downstream a wire mesh using constant temperature anemometry

    Directory of Open Access Journals (Sweden)

    Lizal Frantisek


    Full Text Available Measurement of velocity upstream and downstream a special wire mesh was performed to ascertain the effect of the mesh on the flow. The mesh consisted of two components, a basic rectangular mesh with mesh width 1.22 mm and wire diameter 0.2 mm, and a top steel wool with random position of wires and wire diameter 0.05 mm. The velocity was measured by Constant Temperature Anemometry using single wire probe in a Plexiglas channel of rectangular cross-section. As a first step, measurement of one horizontal and one vertical measuring line was performed 10 mm upstream and 6 mm downstream the wire mesh. A spatial velocity profile upstream of the wire mesh was smooth, while the downstream velocity profile was highly disturbed. However, velocity fluctuations expressed in terms of turbulence intensity downstream of the wire mesh were attenuated down to 1%. Further measurements of the area downstream the wire mesh will be performed to describe the development of the flow.

  13. European Cyber Security Policy


    Bendiek, Annegret


    The gradually developing European cyber security policy tries to establish minimum standards in all EU member states with regard to prevention, resilience and international cooperation. It aims to foster national security without compromising democratic principles or unduly limiting individual liberties. However, it is hard to find a balance between these goals, and the EU’s measures thus inevitably raise questions about the democratic implications of European cyber security policy. Are the i...

  14. Timetabling on European Corridors


    Lischke, Andreas; Führer, B. (Bernhard); Garavagno, G.


    The Path Allocation Re-engineering of Timetable Networks for European Railways (PARTNER) project aims to demonstrate a new way of train path allocation and assembly along international corridors towards a faster and more coordinated railway infrastructure capacity management. PARTNER will assist two neighbour infrastructure managers to develop a common understanding of the effects of international train paths. The results of a survey of European infrastructure managers and railway underta...

  15. European Physical Society awards

    CERN Multimedia


    The winners of the 2004 Accelerator Prizes, awarded by the European Physical Society's Interdivisional Group on Accelerators (EPS-IGA), have been announced. Vladmir Shiltsev (Fermilab) and Igor Meshkov (JINR, Joint Institute of Nuclear Research, Dubna) will be presented with their awards during the 9th European Particle Accelerator Conference, EPAC'04, on 8 July 2004 in Lucerne. Both physicists will also give a talk about their work. More details on:

  16. European Banking Union


    Breuss, Fritz


    The ongoing Euro crisis and the worse economic development in Europe than in the USA are grounded, not the least in the delayed implementation of reforms of the banking sector. Whereas the leaks in economic governance of EMU have been fixed the banking sector is still not stabilised, even five years after Lehman Brothers. From the grand solution of a "European Banking Union" (EBU) only the first pillar, the European Bank Supervision with the single supervisory mechanism (SSM) will come into e...

  17. European DHC Research Issues

    Energy Technology Data Exchange (ETDEWEB)

    Wiltshire, Robin; Williams, Jonathan (Building Research Establishment, BRE, Bucknalls Lane, Watford (United Kingdom)); Werner, Sven (Halmstad University, School of Business and Engineering, Halmstad (Sweden))


    Euroheat and Power is now working towards a European Technology Platform for District Heating and Cooling. In response to this important European DHC research initiative, a preliminary detailed list of research issues within 18 dimensions was elaborated and communicated to more than 100 people in February 2008. After additions and comments received, an updated list of research issues was again distributed in July 2008. This paper contains the current list of suggested research issues

  18. Effects of dietary fatty acid composition on metabolic rate and responses to hypoxia in the European eel (Anguilla anguilla)

    DEFF Research Database (Denmark)

    McKenzie, D.J.; Piraccini, G.; Piccolella, M.


    European eels (Anguilla anguilla, L.) were fed on a commercial diet supplemented either with 15% by dry feed weight of menhaden oil (MO), an oil rich in highly unsaturated fatty acids of the n-3 series (n-3 HUFA), or with 15% by dry feed weight of coconut oil (CO), an oil composed primarily...... of saturated fatty acids (SFA). Following 90 days of feeding, the mean final masses of eels fed the two different oil supplements were similar, and higher than the mean final mass of a group fed the commercial diet alone. The diets created two distinct phenotypes of eels, distinguished by the fatty acid (FA...

  19. A dulal-functional medium voltage level DVR to limit downstream fault currents

    DEFF Research Database (Denmark)

    Blaabjerg, Frede; Li, Yun Wei; Vilathgamuwa, D. Mahinda


    on the other parallel feeders connected to PCC. Furthermore, if not controlled properly, the DVR might also contribute to this PCC voltage sag in the process of compensating the missing voltage, thus further worsening the fault situation. To limit the flow of large line currents, and therefore restore the PCC......, the DVR will therefore be tasked to mitigate even more faults involving downstream loads. Large fault currents would flow through the DVR during a downstream fault before the opening of a circuit breaker. This will cause the voltage at point of common coupling (PCC) to drop, which would affect the loads...... voltage as well as protect the DVR system components, a downstream fault limiting function is proposed and integrated in the DVR operation. A flux-charge-model feedback algorithm is implemented so that the DVR would act as a large virtual inductance in series with the distribution feeder in fault...

  20. Photoperiod control of downstream movements of Atlantic salmon Salmo salar smolts (United States)

    Zydlewski, Gayle B.; Stich, Daniel S.; McCormick, Stephen D.


    This study provides the first direct observations that photoperiod controls the initiation of downstream movement in Atlantic salmon Salmo salar smolts. Under simulated natural day length (LDN) conditions and seasonal increases in temperature, smolts increased their downstream movements five-fold for a period of 1 month in late spring. Under the same conditions, parr did not show changes in downstream movement behaviour. When given a shortened day length (10L:14D) beginning in late winter, smolts did not increase the number of downstream movements. An early increase in day length (16L:8D) in late winter resulted in earlier initiation and termination of downstream movements compared to the LDN group. Physiological status and behaviour were related but not completely coincident: gill Na+/K+-ATPase activity increased in all treatments and thyroid hormone was elevated prior to movement in 16L:8D treatment. The most parsimonious model describing downstream movement of smolts included synergistic effects of photoperiod treatment and temperature, indicating that peak movements occurred at colder temperatures in the 16L:8D treatment than in LDN, and temperature did not influence movement of smolts in the 10L:14D treatment. The complicated interactions of photoperiod and temperature are not surprising since many organisms have evolved to rely on correlations among environmental cues and windows of opportunity to time behaviours associated with life-history transitions. These complicated interactions, however, have serious implications for phenological adjustments and persistence ofS. salar populations in response to climate change.

  1. Habermas on European Constitution and European Identity

    Directory of Open Access Journals (Sweden)

    Éva Biró-Kaszás


    Full Text Available For the last two decades or so philosophers have been reflecting on a set of practical and political concerns in connection with the new political structural arrangements beyond the nation-state. In this article two essays by Jürgen Habermas shall be examined. An attempt shall be made to tackle Habermas’ philosophical concepts of personal and collective identity as well as the role that a constitution may play in building the post-national constellation. It has been shown that Habermas has normative answers. Firstly, according to him, the fragile balance between the legal order and the particular cultures and traditions of a community has to be protected by the constitutional state. For that reason the political culture has to be “decoupled” from the majority culture. Secondly, the democratically structured attempt to achieve shared meaning has to find the delicate balance between the context-transcending universal normative claims and the claims of particular individual and collective life. Thirdly, it is possible to expand legally mediated civil solidarity trans-nationally, across Europe – we may recognize this development as the emergence of European identity –, since the process of democratic will-formation of citizens may get loose from the structures provided by the state if both shared democratic political cultures as well as a European-wide public sphere exist. The European Constitution may have a catalytic function in materialization of these conditions. It has been shown that in his deliberations Habermas tried to find a reflective equilibrium between the normative and the empirical.

  2. Fish oil for use as hydraulic oil

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, T.E. [Maine Univ., Orono, ME (United States). Dept. of Bio-Resource Engineering; Bimbo, A.P. [Zapata Protein, Inc., Reedville, VA (United States). Menhaden Oil Refinery


    A study initiated to find a non-toxic environmentally friendly fluid suitable for use in hydraulic systems, such as in marine and food processing operations, has resulted in a fish-oil-based fluid that appears promising. This paper describes the fluid testing and laboratory and field system tests used to evaluate the fish oil with additive packages. The fish oil with non-toxic additives was endurance tested for durability in complete hydraulic systems in the laboratory and introduced into a commercial system. The results indicate that the oil functioned very well in the systems and the components were compatible with the oil, giving no degradation, wear or performance problems. (author)

  3. Estimating subcatchment runoff coefficients using weather radar and a downstream runoff sensor. (United States)

    Ahm, Malte; Thorndahl, Søren; Rasmussen, Michael R; Bassø, Lene


    This paper presents a method for estimating runoff coefficients of urban drainage subcatchments based on a combination of high resolution weather radar data and flow measurements from a downstream runoff sensor. By utilising the spatial variability of the precipitation it is possible to estimate the runoff coefficients of the separate subcatchments. The method is demonstrated through a case study of an urban drainage catchment (678 ha) located in the city of Aarhus, Denmark. The study has proven that it is possible to use corresponding measurements of the relative rainfall distribution over the catchment and downstream runoff measurements to identify the runoff coefficients at subcatchment level.

  4. Pipe flow pattern downstream of local restrictions studied by an optical method (United States)

    Molochnikov, V. M.; Kratirov, D. V.; Mikheev, A. N.


    An approach to the study of gas flow patterns in circular pipes using 2D methods (PIV, SIV) has been proposed. The approach is based on a special device which is similar to a closed test section of a wind tunnel. It allows measurements of flow parameters downstream of local flow restrictions in circular channels without any optical distortions caused by curved pipe walls. The test results are submitted together with some data on the flow pattern downstream of a gate valve at different channel blockage ratios.

  5. How polluted is the Yangtze river? Water quality downstream from the Three Gorges Dam. (United States)

    Müller, Beat; Berg, Michael; Yao, Zhi Ping; Zhang, Xian Feng; Wang, Ding; Pfluger, August


    The concentrations of major anions and cations, nitrogen and phosphorus, dissolved and particulate trace elements, and organic pollutants were determined for the middle and lower reaches of the Yangtze River (Changjiang) from below the Three Gorges Dam (TGD) to the mouth at Shanghai in November 2006. The concentration of dissolved inorganic phosphate (DIP) was constant at a low level of 6-8 microgP/L, but the concentration of nitrate (NO(3)(-)) approximately doubled downstream and was closely correlated with K(+). This translated to a daily load of well over 1000 t of dissolved inorganic nitrogen (DIN) at Datong. The average concentrations of dissolved Pb (0.078+/-0.023 microg/L), Cd (0.024+/-0.009 microg/L), Cr (0.57+/-0.09 microg/L), Cu (1.9+/-0.7 microg/L), and Ni (0.50+/-0.49 microg/L) were comparable with those in other major world rivers, while As (3.3+/-1.3 microg/L) and Zn (1.5+/-0.6 microg/L) were higher by factors of 5.5 and 2.5, respectively. The trace element contents of suspended particles of As (31+/-28 microg/g), Pb (83+/-34 microg/g), and Ni (52+/-16 microg/g) were close to maximum concentrations recommended for rivers by the European Community (EC). The average concentrations of Cd (2.6+/-1.6 microg/g), Cr (185+/-102 microg/g), Cu (115+/-106 microg/g), and Zn (500+/-300 microg/g) exceeded the EC standards by a factor of two, and Hg (4.4+/-4.7 microg/g) by a factor of 4 to 5. Locally occurring peak concentrations exceed these values up to fourfold, among them the notorious elements As, Hg, and Tl. All dissolved and particulate trace element concentrations were higher than estimates made twenty years ago [Zhang, J., Geochemistry of trace metals from Chinese river/estuary systems: an overview. Estuar Coast Shelf Sci 1995; 41: 631-658.]. The enormous loads of anthropogenic pollutants disposed to the river were diluted by the large water discharge of the Yangtze even during the lowest flow resulting in the relatively low concentration levels of trace

  6. Too much oil

    NARCIS (Netherlands)

    Gerlagh, R.


    Fear for oil exhaustion and its consequences for economic growth has been a driver of a rich literature on exhaustible resources. But our view on oil has remarkably changed. We now also worry about too much oil because of climate change damages associated with oil and other fossil fuel use. In this

  7. Study on Inland River Vessel Fuel-oil Spillage and Emergency Response Strategies (United States)

    Chen, R. C.; Shi, N.; Wang, K. S.


    by making statistics and conducting regression analysis on the carrying volume of vessels navigating on inland rivers and coastal waters, the linear relation between the oil volume carried by a vessel and its gross tonnage (GT) is found. Based on the linear relation, the possible spillage of a 10,000 GT vessel is estimated by using the empirical formula method which is commonly used to measure oil spillage from any vessel spill incident. In the waters downstream of Yangtze River, the trajectory and fates model is used to predict the drifting paths and fates of the spilled oil under three weather scenarios, and then, the emergency response strategies for vessel oil spills are put forth. The results of the research can be used to develop an empirical method to quickly estimate oil spillage and provide recommendations on oil spill emergency response strategies for decision-makers.

  8. Examining market power in the European natural gas market

    Energy Technology Data Exchange (ETDEWEB)

    Egging, R.G. [Energy Research Centre of the Netherlands, Amsterdam (Netherlands). Policy Studies Group; Gabriel, S.A. [University of Maryland, College Park, MD (United States). Dept. of Civil and Environmental Engineering


    In this paper, we develop a mixed complementarity equilibrium model for the European natural gas market. This model has producers as Cournot players with conjectured supply functions relative to their rivals. As such, these producers can withhold production to increase downstream prices for greater profits. The other players are taken to be perfectly competitive and are combined with extensive pipeline, seasonal, and other data reflecting the current state of the market. Four market scenarios are run to analyze the extent of market power by these producers as well as the importance of pipeline and storage capacity. (author)

  9. Assessment of the effects of oil spillage on groundwater in an inland ...

    African Journals Online (AJOL)

    The heavy presence of hydrocarbons, reduced dissolved oxygen and high conductivity values inform the contamination of a local groundwater resource by an oil pipeline spillage in Isukwuato Local Government Area of Abia State. Monitoring the impact on a spring water source 90m downstream of the spill point showed ...

  10. Preventing major offshore oil spill accidents in China : Lessons from the EU offshore safety directive

    NARCIS (Netherlands)

    Yang, Yuan

    With offshore oil and gas activities growing and moving to further and deeper water, offshore oil-spill prevention has become a significant component of marine environmental protection. To reduce the risk of major accidents and limit their consequences, the European Union issued the Offshore Safety

  11. Contact Allergy to Neem Oil. (United States)

    de Groot, Anton; Jagtman, Berend A; Woutersen, Marjolijn

    A case of allergic contact dermatitis from neem oil is presented. Neem oil (synonyms: Melia azadirachta seed oil [INCI name], nim oil, margosa oil) is a vegetable (fixed) oil obtained from the seed of the neem tree Azadirachta indica by cold pressing. Contact allergy to neem oil has been described previously in only 3 patients. The allergen(s) is/are unknown.

  12. Transnational European Television Drama

    DEFF Research Database (Denmark)

    Bondebjerg, Ib; Redvall, Eva Novrup; Helles, Rasmus

    This book deals with the role of television drama in Europe as enabler of transnational, cultural encounters for audiences and the creative community. It demonstrates that the diversity of national cultures is a challenge for European TV drama but also a potential richness and source of creative...... variation. Based on data on the production, distribution and reception of recent TV drama from several European countries, the book presents a new picture of the transnational European television culture. The authors analyse main tendencies in television policy and challenges for national broadcasters...... coming from new global streaming services. Comparing cases of historical, contemporary and crime drama from several countries, this study shows the importance of creative co-production and transnational mediated cultural encounters between national cultures of Europe....

  13. The Europeanization of Eurosceptics?

    DEFF Research Database (Denmark)

    Dutceac Segesten, Anamaria; Bossetta Jr, Michael Joseph

    with the case of Sweden. Sweden is a good example because it has a high density of internet use, a politically active population as reflected in voter turnout and many politicians and political parties with a web presence. The main research questions of the paper are: Which actors are involved in the Swedish...... of a Europeanized network of anti-European voices for European integration and democracy. We plan to operationalize our research question through the use of webcrawling (i.e. Issue Crawler) and social media analytic softwares (Twitonomy and Bluenod). Using these softwares we will be able to discern whether...... or not non-Swedish Twitter users are participating in and/or affecting the Swedish Eurosceptic dialogue on social media....

  14. European Analytical Column

    DEFF Research Database (Denmark)

    Karlberg, B.; Grasserbauer, M.; Andersen, Jens Enevold Thaulov


    The European Analytical Column has once more invited a guest columnist to give his views on various matters related to analytical chemistry in Europe. This year, we have invited Professor Manfred Grasserbauer of the Vienna University of Technology to present some of the current challenges...... for European analytical chemistry. During the period 2002–07, Professor Grasserbauer was Director of the Institute for Environment and Sustainability, Joint Research Centre of the European Commission (EC), Ispra, Italy. There is no doubt that many challenges exist at the present time for all of us representing...... a major branch of chemistry, namely analytical chemistry. The global financial crisis is affecting all branches of chemistry, but analytical chemistry, in particular, since our discipline by tradition has many close links to industry. We have already noticed decreased industrial commitment with respect...

  15. European Universe Awareness (United States)

    Russo, P.; Miley, G.; Westra van Holthe, F.; Schrier, W.; Reed, S.


    The European Universe Awareness (EU-UNAWE) programme uses the beauty and grandeur of the cosmos to encourage young children, particularly those from underprivileged backgrounds, to develop an interest in science and technology and to foster a sense of global citizenship. EU-UNAWE is already active in 40 countries and comprises a global network of almost 500 astronomers, teachers and other educators. The programme was recently awarded a grant of 1.9 million euros by the European Union so that it can be further developed in five European countries and South Africa. The grant will be used to organise teacher training workshops and to develop educational materials, such as an astronomy news service for children and games. During this presentation we will outline some of the biggest achievements of EU-UNAWE to date and discuss future plans for the programme.

  16. Movement patterns of seaward migrating European eel (Anguilla anguilla) at a complex of riverine barriers: implications for conservation

    DEFF Research Database (Denmark)

    Piper, Adam T.; Svendsen, Jon Christian; Wright, Rosalind M.


    , this is currently lacking for many species. Employing high-resolution positioning telemetry, this study examined movements of downstream migrating adult European eel, Anguilla anguilla, as they encountered a complex of water control structures in one location on the River Stour, southern England. The distribution...

  17. The European Identity

    Directory of Open Access Journals (Sweden)

    Alberto Martinelli


    Full Text Available European identity is not only a scientifically interesting question, but also a politically important issue: in fact, sixty years after the signing of the Treaty of Rome, the European Union finds itself for the first time facing risks that threaten its own existence. The European Union is a limited and incomplete project because Europe’s economic integration has not been accompanied by a genuine supranational political union and greater cultural integration. The deficit of democratic representation and cultural integration is due to the fact that the community process is based only on economic rationality and not on a feeling of common belonging. In the current situation in which the Union faces difficult challenges which threaten to undermine the future, it necessary to affirm the policy of interests with a policy of identity. In this essay, we will first concentrate on the concept of identity – that is on the nucleus of values and common institutions –; then we will discuss how the European identity has changed over time (also in relation to national identities and what are the mechanisms that may favour its taking root in the current situation. The European project of political unification needs to be re-emphasized, finding the way to a European collective identity, not contrasted with but alongside the different national identities, referring to loyalty and shared commitment to a whole collection of cultural values: fundamental human rights, civil liberties, democratic political institutions, rule of law, freedom of movement of people, goods and capital, social justice and non-violent resolution of conflicts.


    Directory of Open Access Journals (Sweden)

    Razvan VOICU


    Full Text Available Longitudinal connectivity represent the way in which organisms move the energy and material exchanges located throughout the water. Fragmentation the longitudinal connectivity of watercourses caused by dams or other hydrotechnical constructions represent a major impact on sediment transport, hydrological regime, downstream moving and biota migration. The hydromorphological elements (river continuity, as well as chemical, biological, physicochemical elements characterize the ecological status of rivers.Migratory fish species: nase (Chondrostoma nasus - protected by Bern Convention - Appendix III and barbel (Barbus barbus - rare species, protected Habitats Directive (Annex V, annex 4A of Low nr.462 and Red List of RBDD are blocked but the Hydrotechnical constructions (discharge sills, dams etc located across the watercourse Somes Mic River. One of the important think of this system is the gravitational fall of water. This solution will lead to the restoration of the longitudinal connection of the Someşul Mic River in the Manastur neighborhood. România is part of the European Union and it has the obligation to implement the provisions of the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004. This engineering solution for fish fauna migration upstream – downstream of the spillways supports the Water Framework Directive 2000/60/EC, transposed into Romanian legislation by the Water Law 107/1996 as supplemented and amended (Act 310/2004.

  19. 5 X 5 rod bundle flow field measurements downstream a PWR spacer grid

    Energy Technology Data Exchange (ETDEWEB)

    Castro, Higor F.P.; Silva, Vitor V A.; Santos, André A.C.; Veloso, Maria A.F., E-mail:, E-mail:, E-mail:, E-mail: [Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG (Brazil); Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)


    The spacer grids are structures present in nuclear fuel assembly of Pressurized Water Reactors (PWR). They play an important structural role and also assist in heat removal through the assembly by promoting increased turbulence of the flow. Understanding the flow dynamics downstream the spacer grid is paramount for fuel element design and analysis. This paper presents water flow velocity profiles measurements downstream a spacer grid in a 5 x 5 rod bundle test rig with the objective of highlighting important fluid dynamic behavior near the grid and supplying data for CFD simulation validation. These velocity profiles were obtained at two different heights downstream the spacer grid using a LDV (Laser Doppler Velocimetry) through the top of test rig. The turbulence intensities and patterns of the swirl and cross flow were evaluated. The tests were conducted for Reynolds numbers ranging from 1.8 x 10{sup 4} to 5.4 x 10{sup 4}. This experimental research was carried out in thermo-hydraulics laboratory of Nuclear Technology Development Center – CDTN. Results show great repeatability and low uncertainties (< 1.24 %). Details of the flow field show how the mixture and turbulence induced by the spacer grid quickly decays downstream the spacer grid. It is shown that the developed methodology can supply high resolution low uncertainty results that can be used for validation of CFD simulations. (author)

  20. Influence of peak flow changes on the macroinvertebrate drift downstream of a Brazilian hydroelectric dam. (United States)

    Castro, D M P; Hughes, R M; Callisto, M


    Successive daily peak flows from hydropower plants can disrupt aquatic ecosystems and alter the composition and structure of macroinvertebrates downstream. We evaluated the influence of peak flow changes on macroinvertebrate drift downstream of a hydroelectric plant as a basis for determining ecological flows that might reduce the disturbance of aquatic biota. The aim of this study was to assess the influence of flow fluctuations on the seasonal and daily drift patterns of macroinvertebrates. We collected macroinvertebrates during fixed flow rates (323 m3.s-1 in the wet season and 111 m3.s-1 in the dry season) and when peak flows fluctuated (378 to 481 m3.s-1 in the wet season, and 109 to 173 m3.s-1 in the dry season) in 2010. We collected 31,924 organisms belonging to 46 taxa in the four sampling periods. Taxonomic composition and densities of drifting invertebrates differed between fixed and fluctuating flows, in both wet and dry seasons, but family richness varied insignificantly. We conclude that macroinvertebrate assemblages downstream of dams are influenced by daily peak flow fluctuations. When making environmental flow decisions for dams, it would be wise to consider drifting macroinvertebrates because they reflect ecological changes in downstream biological assemblages.

  1. From Process Development to Manufacturing: Lab-Intensive Courses in Downstream Bioprocessing (United States)

    Gilleskie, Gary L.; Reeves, Baley A.


    Most chemical engineering graduates work in industry, a fact that underscores the need for courses to provide experiences that prepare them for industry. The Biomanufacturing Training and Education Center (BTEC) at North Carolina State University has addressed this need by developing and delivering a comprehensive downstream bioprocessing program…

  2. Physicochemical Characteristics of River Water Downstream of a Large Tropical Hydroelectric Dam

    Directory of Open Access Journals (Sweden)

    Teck-Yee Ling


    Full Text Available Water quality in the downstream river of a hydroelectric dam may be affected by the structural design and operation. To date, little is known about the water quality downstream of the largest dam in Malaysia, the Bakun hydroelectric dam. Therefore, the objective of the study was to determine the water quality downstream of the dam when the spillway was closed and when it was opened. Results of the study indicate that the dam plays a significant role in regulating the water quality downstream of it. When the spillway was closed, pH and oxygen were lower in the river where DO was below 5 mg/L. When the spillway was opened, the water quality improved in terms of oxygen content (>8.0 mg/L, total sulphide (TS, and chemical oxygen demand (COD but deteriorated in terms of five-day biochemical oxygen demand (BOD5, total ammonia nitrogen (TAN, and total phosphorus (TP. Additionally, the intensity of the impacts, particularly BOD5, COD, and TAN, shows a declining trend as distance from the dam increases. This study shows that impacts on the water quality extend to a distance of 32 km from the dam particularly turbidity and DO and opening the spillway changes the water quality significantly.

  3. Cetuximab insufficiently inhibits glioma cell growth due to persistent EGFR downstream signaling

    DEFF Research Database (Denmark)

    Hasselbalch, Benedikte; Lassen, Ulrik; Poulsen, Hans S


    Overexpression and/or amplification of the epidermal growth factor receptor (EGFR) is present in 35-45% of primary glioblastoma multiforme tumors and has been correlated with a poor prognosis. In this study, we investigated the effect of cetuximab and intracellular signaling pathways downstream...

  4. Estimating Subcatchment Runoff Coefficients using Weather Radar and a Downstream Runoff Sensor

    DEFF Research Database (Denmark)

    Ahm, Malte; Thorndahl, Søren Liedtke; Rasmussen, Michael R.


    This paper presents a method for estimating runoff coefficients of urban drainage subcatchments based on a combination of high resolution weather radar data and flow measurements from a downstream runoff sensor. By utilising the spatial variability of the precipitation it is possible to estimate...

  5. Effect of stilling basin shape on the hydraulic characteristics of the flow downstream radial gates

    Directory of Open Access Journals (Sweden)

    Abdelazim M. Ali


    Full Text Available Barrage regulators are considered as one of the most important projects in the Egyptian irrigation practice, which is obvious by its controlling of the released discharge and both of upstream and downstream water levels. In the present time, the ministry of water resources and irrigation starts to construct new barrages on the River Nile instead of the oldest ones, which are not able to withstand the requirements of increasing head difference between the upstream and downstream water levels upon the gates. The present study was focused on investigating the effect of different shapes of stilling basins of regulator on the length of the submerged hydraulic jump, velocity profiles along the apron, and local scour downstream regulator floor. Extensive experimental program was conducted on a re-circulating flume with 1.0 m wide, 26.0 m long and 1.2 m deep, with discharges range from 40 to 190 l/s. The relative velocity near bed, and shear Reynolds number were studied to fix the best shape of stilling basin that could reduce both of length of submerged hydraulic jump and local scour downstream stilling basin. Statistical equation was developed to correlate the length of submerged jump with the other independent parameters. Finally, clear matching of results from the length of jump and velocity analysis was investigated.

  6. 40 CFR 80.220 - What are the downstream standards for GPA gasoline? (United States)


    ... GPA gasoline? 80.220 Section 80.220 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Geographic Phase-in Program § 80.220 What are the downstream standards for GPA gasoline? (a) GPA gasoline. (1) During...

  7. 40 CFR 80.219 - Designation and downstream requirements for GPA gasoline. (United States)


    ... requirements for GPA gasoline. 80.219 Section 80.219 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS (CONTINUED) REGULATION OF FUELS AND FUEL ADDITIVES Gasoline Sulfur Geographic Phase-in Program § 80.219 Designation and downstream requirements for GPA gasoline. The requirements and...

  8. Full-scale observation of the flow downstream of a suspension bridge deck

    DEFF Research Database (Denmark)

    Cheynet, Etienne; Jakobsen, Jasna Bogunović; Snæbjörnsson, Jónas


    The paper presents a full-scale observation of the flow conditions downstream of a suspension bridge by a system of synchronized short-range dual-Doppler wind lidars. The lidar units were deployed directly on the bridge walkway during a four-day pilot experiment. The wind velocity was monitored...

  9. Climate change impact on infection risks during bathing downstream of sewage emissions from CSOs or WWTPs

    NARCIS (Netherlands)

    Sterk, Ankie; de Man, Heleen; Schijven, Jack F; de Nijs, Ton; de Roda Husman, Ana Maria


    Climate change is expected to influence infection risks while bathing downstream of sewage emissions from combined sewage overflows (CSOs) or waste water treatment plants (WWTPs) due to changes in pathogen influx, rising temperatures and changing flow rates of the receiving waters. In this study,

  10. Climate change impact on infection risks during bathing downstream of sewage emissions from CSOs or WWTPs. (United States)

    Sterk, Ankie; de Man, Heleen; Schijven, Jack F; de Nijs, Ton; de Roda Husman, Ana Maria


    Climate change is expected to influence infection risks while bathing downstream of sewage emissions from combined sewage overflows (CSOs) or waste water treatment plants (WWTPs) due to changes in pathogen influx, rising temperatures and changing flow rates of the receiving waters. In this study, climate change impacts on the surface water concentrations of Campylobacter, Cryptosporidium and norovirus originating from sewage were modelled. Quantitative microbial risk assessment (QMRA) was used to assess changes in risks of infection. In general, infection risks downstream of WWTPs are higher than downstream CSOs. Even though model outputs show an increase in CSO influxes, in combination with changes in pathogen survival, dilution within the sewage system and bathing behaviour, the effects on the infection risks are limited. However, a decrease in dilution capacity of surface waters could have significant impact on the infection risks of relatively stable pathogens like Cryptosporidium and norovirus. Overall, average risks are found to be higher downstream WWTPs compared to CSOs. Especially with regard to decreased flow rates, adaptation measures on treatment at WWTPs may be more beneficial for human health than decreasing CSO events. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  11. Drifting plankton from a reservoir subsidize downstream food webs and alter community structure. (United States)

    Doi, Hideyuki; Chang, Kwang-Hyeon; Ando, Takamitsu; Imai, Hiroyuki; Nakano, Shin-ichi; Kajimoto, Akio; Katano, Izumi


    Subsidy between ecosystems has been considered in many natural ecosystems, and should alter food webs and communities in human-impacted ones. We estimated how drifting plankton from a reservoir contribute to downstream food webs and showed that they alter community structures over a 10-km reach below the dam. To estimate the contribution of the drifting plankton to macroinvertebrates, we used C and N isotopes and an IsoSource mixing model. In spring and autumn, contributions of plankton to collector-filterer species were highest 0.2 km downstream of the dam, and clearly decreased from 0.2 to 10 km. At 0.2 km, the contribution of plankton to a predator stonefly was remarkably high. These results indicated that drifting plankton from a dam reservoir could subsidize downstream food webs and alter their energy base, but the importance of this subsidy decreased as distance from the reservoir increased. The general linear models indicated that the abundance of collector-filterers and predators was related positively to zooplankton density in stream water. Thus, food source alteration by drifting plankton also influenced the community structures downstream of the dam.

  12. Hes repressors are essential regulators of hematopoietic stem cell development downstream of notch signaling

    NARCIS (Netherlands)

    J. Guiu (Jordi); R. Shimizu (Ritsuko); C. D'Altri; S.T. Fraser (Stuart); S. Hatakeyama (Shingo); E.H. Bresnick (Emery); T. Kageyama (Tsutomu); E.A. Dzierzak (Elaine); M. Yamamoto (Masayuki); L. Espinosa (Lluis); A. Bigas (Anna)


    textabstractPrevious studies have identified Notch as a key regulator of hematopoietic stem cell (HSC) development, but the underlying downstream mechanisms remain unknown. The Notch target Hes1 is widely expressed in the aortic endothelium and hematopoietic clusters, though Hes1-deficient mice show

  13. A comparison of machine learning techniques for predicting downstream acid mine drainage

    CSIR Research Space (South Africa)

    van Zyl, TL


    Full Text Available We consider the challenge of providing downstream predictions of water quality using a time-series of upstream insitu measurements and a time-series of remote sensed precipitation data from the Tropical Rainfall Measuring Mission (TRMM). We use a...

  14. Stress analysis of the modified Pulsed Neutron Activation system downstream shield support structure

    Energy Technology Data Exchange (ETDEWEB)

    Mosby, W.R.


    The modified LOFT Pulsed Neutron Activation (PNA) System downstream shielding support structure was stress analyzed for deadweight and worst-case LOCE loads. No deficiencies were found in the structure. This stress analysis was performed for the PNA Shielding Configuration that has been used on Test L3-2 and that is to be used on Test L3-7.

  15. Linking Three Gorges Dam and downstream hydrological regimes along the Yangtze River, China

    NARCIS (Netherlands)

    Mei, X.; Dai, Z.; Van Gelder, P.H.A.J.M.; Gao, J.


    The magnitude of anthropogenic influence, especially dam regulation, on hydrological system is of scientific and practical value for large river management. As the largest dam in the world by far, Three Gorges Dam (TGD) is expected to be a strong evidence on dam impacts on downstream hydrological

  16. Novel Techniques for Quantification of Correlation Between Primary Liquid Jet Breakup and Downstream Spray Characteristics (United States)


    unlimited. 5 1. Introduction Several liquid -fuelled combustion systems, such as liquid propellant rocket engines and gas turbines... liquid sheet[1], [2], [3]. Considering the challenges in studying spray combustion due to interacting complex physical and chemical processes...AFRL-AFOSR-JP-TR-2016-0084 Novel techniques for quantification of correlation between primary liquid jet breakup and downstream spray characteristics



    Miraldi, E; Giachetti, D; MAZZONI, G.; Biagi, M.


    Aim. It is well known that the pharmacological activity of essential oils depends on their major components, which may vary enormously. The aim of the present study was to determine the chemical composition of samples of essential oil of rosemary of different origins, in order to identify the main therapeutic constituents, according to European Pharmacopoeian (EP). Material and Methods. Analytical GC/MS was carried out on a total of eight samples of essential oil of rosemary: seven samples we...

  18. European Gas Dependency


    Antonsen, Iben; Bieber, Martin; Gandrup, Tobias; Lehmann, Tina; Weinberger, Ashley


    The focal point of the project is, as it is implied in the title, European gas dependency, to be more specific; the dependency of Russian gas. We chose Russia, because the EU's import of gas is mainly supplied by Russia. We present background information and knowledge to describe why the case is of relevance and that a situation of dependency exists. We solely look at the dependency from the European Union's point of view, taking point of departure in the Green Paper. The Green Paper is a pap...

  19. European Values and Globalization

    Directory of Open Access Journals (Sweden)

    Heinz Theisen


    Full Text Available Good Governance, Social Market Economy, Culture and Education are the decisive elements for Human Development. We need a third way between the extremes of the Utopian Global Free Market and a new nationalism. A Social Market Economy and the European Model of a Union could be such third way. For a new Social Market Economy we need a renaissance of the European dialectics between culture and society, idealism and materialism, religion and enlightenment, solidarity and profitability. The balancing of those poles is deeply rooted in our best traditions. 

  20. VERAM - Vision and Roadmap for European Raw Materials (United States)

    Baumgarten, Wibke; Vashev, Boris


    The overall objective of VERAM project is to produce a Vision and Roadmap for European Raw Materials in 2050 based on raw materials research and innovation (R&I) coordination. Two leading European Technology Platforms (ETPs): ETP SMR (Sustainable Minerals Resources) and FTP (Forest Technology Platform) are joining forces to develop a common vison and roadmap with the support of ECTP (European Construction Technology Platform), represented by UNIVPM, SusChem (ETP for Sustainable Chemistry), represented by Cefic, EuMaT (Advanced Materials ETP), represented by VITO, ERAMIN 2, represented by Research Centre JUELICH and WoodWisdom Network Plus represented by the Agency for Renewable Resources (FNR). This partnership provides VERAM with expertise from downstream applications and additional knowledge on non-biotic and biotic raw materials. The project encourages capacity building as well as transfer of knowledge. It expects to provide an innovation reference point for the European Institute of Innovation & Technology (EIT) Raw Materials (formerly the KIC Raw MatTERS), to coordinate the network involved in the European Innovation Partnership (EIP) on Raw Materials Commitments and relevant proposals funded under Horizon 2020. It provides a platform for identifying gaps and complementarities and enables their bridging. VERAM will be able to advise the European Commission and Member States on future research needs and policies to stimulate innovation and assist in overcoming fragmentation in the implementing the EIP Raw Materials Strategic Implementation Plan. VERAM looks for mutually beneficial information exchange, encourages cross-fertilization between actions undertaken by different raw material industries, and expects to accelerate exploitation of breakthrough innovations. One of the main outcomes of the project is the presentation of a common long term 2050 Vision and Roadmap for relevant raw materials including metals, industrial minerals and aggregates and wood. The

  1. Water Stress in Global Transboundary River Basins: Significance of Upstream Water Use on Downstream Stress (United States)

    Munia, H.; Guillaume, J. H. A.; Mirumachi, N.; Porkka,M.; Wada, Yoshihide; Kummu, M.


    Growing population and water demand have increased pressure on water resources in various parts of the globe, including many transboundary river basins. While the impacts of upstream water use on downstream water availability have been analyzed in many of these international river basins, this has not been systematically done at the global scale using coherent and comparable datasets. In this study, we aim to assess the change in downstream water stress due to upstream water use in the world's transboundary river basins. Water stress was first calculated considering only local water use of each sub-basin based on country-basin mesh, then compared with the situation when upstream water use was subtracted from downstream water availability. Wefound that water stress was generally already high when considering only local water use, affecting 0.95-1.44 billion people or 33%-51% of the population in transboundary river basins. After accounting for upstream water use, stress level increased by at least 1 percentage-point for 30-65 sub-basins, affecting 0.29-1.13 billion people. Altogether 288 out of 298 middle-stream and downstream sub-basin areas experienced some change in stress level. Further, we assessed whether there is a link between increased water stress due to upstream water use and the number of conflictive and cooperative events in the transboundary river basins, as captured by two prominent databases. No direct relationship was found. This supports the argument that conflicts and cooperation events originate from a combination of different drivers, among which upstream-induced water stress may play a role. Our findings contribute to better understanding of upstream-downstream dynamics in water stress to help address water allocation problems.

  2. Willingness of upstream and downstream resource managers to engage in compensation schemes for environmental services

    Directory of Open Access Journals (Sweden)

    Chapika Sangkapitux


    Full Text Available Providing compensation for agricultural conservation practices adopted by upstream farmers is still an alien concept in the Thai political context. The governance of common-pool natural resources, such as forest and water, has traditionally been under the control of powerful government line agencies, while the contribution of local communities to natural resource conservation have been hardly recognized by policy-makers. Drawing on a case study in Mae Sa watershed, Chiang Mai province, northern Thailand, this paper discusses the potential of developing compensation schemes in a socio-political context where upland farmers – mostly belonging to ethnic minority groups – tend to be considered a threat to the natural resource base rather than providers of environmental services. Based on data obtained from 371 households in the upstream communities and 151 households in the downstream communities of the watershed, upstream resource managers’ willingness to accept compensation for the conservation measures and downstream resource managers’ willingness to pay for water resource improvements were estimated through the use of choice experiments. Results from the study suggest that downstream resource managers would be willing to provide on average nearly 1% of their annual income for a substantial improvement of the quantity and quality of water resources, which could be achieved by compensating upstream farmers’ change of their agricultural systems towards more environment-friendly practices. Both willingness to pay of downstream respondents and willingness of upstream resource managers to accept compensation were positively correlated with age, education, participation in environmental conservation activities and previous experiences with droughts and/or erosion. The paper concludes that there is a clear potential for establishing compensation schemes for provision of environmental services in northern Thai watersheds. The important policy

  3. C, N, P export regimes in rivers from headwater to downstream catchments (United States)

    Dupas, Rémi; Musolff, Andreas; Jawitz, James W.; Rao, P. Suresh C.; Fleckenstein, Jan H.; Rode, Michael; Borchardt, Dietrich


    Excessive amounts of nutrients and dissolved organic matter in freshwater bodies affect aquatic ecosystems. In this study, the spatial and temporal variability of nitrate (NO3), dissolved organic carbon (DOC) and soluble reactive phosphorus (SRP) was analyzed along the Selke river continuum from 1 - 3 km2 headwater catchments to 184 - 456 km2 downstream catchments, within the TERENO Harz/Central German Lowland Observatory. Three headwater catchments were selected as archetypes of the main landscape units (land use x soil type) present in the Selke catchment. Export regimes in these catchments were interpreted in terms of NO3, DOC and SRP land-to-stream transfer processes. Differences between export regimes in headwater and downstream catchments were interpreted in terms of in-stream processes and contribution of point source emissions. The results showed that the NO3 seasonal dynamics were opposite compared to DOC and SRP in all three headwater catchments. These dynamics were interpreted as the result of the interplay of hydrological and biogeochemical processes, for which riparian wetlands were hypothesized to play a determining role. In the two downstream catchments, NO3 was transported almost conservatively, except during the summer period where in-stream retention could exceed 50%. Allochtonous DOC was consumed in the upstream river section (with low light and nutrient availability) and autochthonous DOC was produced in the downstream river section (with high light and nutrients availability); the natural export regime of SRP mimicked a point source signal, which may lead to misattribution and thus overestimation of domestic contribution to phosphorus loads in rivers. Monitoring the river continuum from headwater to downstream rivers proved effective to investigate jointly land-to-stream and in-stream transport and transformation processes.

  4. Carbon and nutrient export regimes from headwater catchments to downstream reaches (United States)

    Dupas, Rémi; Musolff, Andreas; Jawitz, James W.; Rao, P. Suresh C.; Jäger, Christoph G.; Fleckenstein, Jan H.; Rode, Michael; Borchardt, Dietrich


    Excessive amounts of nutrients and dissolved organic matter in freshwater bodies affect aquatic ecosystems. In this study, the spatial and temporal variability in nitrate (NO3-), dissolved organic carbon (DOC) and soluble reactive phosphorus (SRP) was analyzed in the Selke (Germany) river continuum from three headwaters draining 1-3 km2 catchments to two downstream reaches representing spatially integrated signals from 184-456 km2 catchments. Three headwater catchments were selected as archetypes of the main landscape units (land use × lithology) present in the Selke catchment. Export regimes in headwater catchments were interpreted in terms of NO3-, DOC and SRP land-to-stream transfer processes. Headwater signals were subtracted from downstream signals, with the differences interpreted in terms of in-stream processes and contributions from point sources. The seasonal dynamics for NO3- were opposite those of DOC and SRP in all three headwater catchments, and spatial differences also showed NO3- contrasting with DOC and SRP. These dynamics were interpreted as the result of the interplay of hydrological and biogeochemical processes, for which riparian zones were hypothesized to play a determining role. In the two downstream reaches, NO3- was transported almost conservatively, whereas DOC was consumed and produced in the upper and lower river sections, respectively. The natural export regime of SRP in the three headwater catchments mimicked a point-source signal (high SRP during summer low flow), which may lead to overestimation of domestic contributions in the downstream reaches. Monitoring the river continuum from headwaters to downstream reaches proved effective to jointly investigate land-to-stream and in-stream transport, and transformation processes.

  5. Favorable fragmentation: river reservoirs can impede downstream expansion of riparian weeds. (United States)

    Rood, Stewart B; Braatne, Jeffrey H; Goater, Lori A


    River valleys represent biologically rich corridors characterized by natural disturbances that create moist and barren sites suitable for colonization by native riparian plants, and also by weeds. Dams and reservoirs interrupt the longitudinal corridors and we hypothesized that this could restrict downstream weed expansion. To consider this "reservoir impediment" hypothesis we assessed the occurrences and abundances of weeds along a 315-km river valley corridor that commenced with an unimpounded reach of the Snake River and extended through Brownlee, Oxbow, and Hells Canyon reservoirs and dams, and downstream along the Snake River. Sampling along 206 belt transects with 3610 quadrats revealed 16 noxious and four invasive weed species. Ten weeds were upland plants, with Canada thistle (Cirsium arvense) restricted to the upstream reaches, where field morning glory (Convolvulus arvensis) was also more common. In contrast, St. John's wort (Hypericum perforatum) was more abundant below the dams, and medusahead wildrye (Taeniatherum caput-medusae) occurred primarily along the reservoirs. All seven riparian species were abundant in the upstream zones but sparse or absent below the dams. This pattern was observed for the facultative riparian species, poison hemlock (Conium maculatum) and perennial pepperweed (Lepidium latifolium), the obligate riparian, yellow nut sedge (Cyperus esculentus), the invasive perennial, reed canary grass (Phalaris arundinacea), and three invasive riparian trees, Russian olive (Elaeagnus angustifolia), false indigo (Amorpha fruticosa), and tamarisk (Tamarix spp.). The hydrophyte purple loosestrife (Lythrum salicaria) was also restricted to the upstream zone. These longitudinal patterns indicate that the reservoirs have impeded the downstream expansion of riparian weeds, and this may especially result from the repetitive draw-down and refilling of Brownlee Reservoir that imposes a lethal combination of drought and flood stress. The dams and

  6. Soluble oil flooding

    Energy Technology Data Exchange (ETDEWEB)

    Holm, L.W.; Knight, R.K.


    A soluble oil-polymer flooding process used in previously waterflooded reservoirs utilizes oleic, micellar solutions which, when injected as small slugs and driven by polymer thickened water, are capable of displacing all oil and water contacted. During the micellar flood, oil and water are displaced from reservoir rock by one or more of the following mechanisms: (1) miscible-type displacement of oil by soluble oil; (2) miscible-type displacement of resident water by injection water and soluble oil; (3) formation of microemulsions by the intermingling of soluble oil and injected water; and (4) reduction of interfacial tension between oil and water phases where both are present. The Higgs Unit, site of a field test of soluble oil flooding, is a small pool in the Jones County Regular field near Abilene, Tex. Field data, special equipment, test evaluation, and field test conclusions are given for this operation.

  7. Measuring Iranian Petroleum Downstream Supply Chain Management Performance; : A Combination of Analytical Hierarchy Process and Balance Score Card


    Norouzi, Saba


    Petroleum downstream is a strategic and important industry for any nation. It supplies most of transport and travel needs and provides petrochemical business raw material, which is one of the infrastructure industries. Considering the importance of petroleum downstream and due to a very volatile crude and product market, one of the industry’s main targets is to meet customers’ requirements with administrating downstream supply chain efficiently. Supply chain management (SCM) is a strategic to...

  8. Causality in Europeanization Research

    DEFF Research Database (Denmark)

    Lynggaard, Kennet


    to develop discursive institutional analytical frameworks and something that comes close to the formulation of hypothesis on the effects of European Union (EU) policies and institutions on domestic change. Even if these efforts so far do not necessarily amount to substantive theories or claims of causality...

  9. Measuring European selves

    DEFF Research Database (Denmark)

    Antalikova, Radka

    Taking the perspective of cross-cultural psychology, the current thesis sets out to investigate self in a European context. For this purpose, the thesis first thoroughly reviews the most prominent conceptualizations of self in cross-cultural psychology, specifically focusing on disentangling...... to the field of cross-cultural psychology, specifically highlighting the utility of autobiographical memories as measures of self....

  10. European Psychology Map

    Directory of Open Access Journals (Sweden)



    Full Text Available The Institute for Psychology Information (ZPID compiled an extensive list of European psycho-logical organizations, comprised of university departments, research institutions, professional associa-tions and publishing houses. The list is available on the ZPID website, together with a web mapping applet that indicates the exact geographical location of the organizations.

  11. European Pine Shoot Moth (United States)

    William E. Miller; Arthur R. Hastings; John F. Wootten


    In the United States, the European pine shoot moth has caused much damage in young, plantations of red pine. It has been responsible for reduced planting of red pine in many areas. Although attacked trees rarely if ever die, their growth is inhibited and many are, deformed. Scotch pine and Austrian pine (Pinus nigra Arnold) are usually not so badly damaged. Swiss...

  12. Inequalities in European cities

    NARCIS (Netherlands)

    Musterd, S.; Ostendorf, W.; Smith, S.J.; Elsinga, M.; Eng, O.S.; Fox O’Mahony, L.; Wachter, S.


    The consequences of inequalities in European cities are a big fear for many governments at the state and urban levels. Journalists, as well as many scholars who are dealing with urban issues, express their fears about the development of social, ethnic, and spatial divisions. Population categories

  13. European 'Stabilisation through Association'

    DEFF Research Database (Denmark)

    Rodt, Annemarie Peen

    ’s success in repeatedly reconciling a divided continent and complemented its efforts to build peace beyond its borders. But does the EU (continue to) deserve such praise? This contribution examines European peacebuilding from the early inte-gration of post-World War Two economies, through the uniting...

  14. European Integration and Globalization

    Directory of Open Access Journals (Sweden)

    Diana Bobica


    Full Text Available According to many, the term globalization is able to explain any phenomenon whatsoever, be it positive or negative, that takes place within the global social system. It seems like a sort of magical formula, which is to be found in the speeches of all sorts of people, be they economists, politicians, businessmen or sociologists. However this magical formula of globalization has its limitations, since it encompasses a certain amount of quibbling, beyond which not many can pass. In the context of globalization there appears the question on its role in the process of European integration. Is European integration a part of this global process or, quite on the contrary, does it present certain distinctive features, as it moulds itself differently from the globalization phenomenon? A clear-cut answer seems difficult because of the various aspects involved. Not only the general phenomenon of globalization, but also the economic integration on European level is based on the liberalization of markets and on the opening of national economies towards the exterior,having as direct consequence the intensification of trade exchanges. If from a global point of view one may talk of a market fundamentalism in that the market principles know no boundary, European integration on the other hand implies not only market economy, but also a guided and monitored action of Member Statesaccording to the needs of the whole entity, also taking into consideration - as far as possible – all aspects and consequences on social level.

  15. Becoming Pan-European?

    DEFF Research Database (Denmark)

    Schulz-Forberg, Hagen; Brüggemann, Michael


    be platforms of a transnational European discourse. Four ideal-types of transnational media can be distinguished: (1) national media with a transnational mission, (2) international media, (3) pan-regional media and (4) global media. Within this framework the article analyses transnational media in Europe...

  16. European Metals Conference

    CERN Document Server

    Vereecken, Jean


    This volume contains the papers that will be presented at 'EMC '91 '-the European Metals Conference-to be held in Brussels, Belgium, from 15 to 20 September 1991, and organized by Benelux Metallurgie, GDMB (Gesellschaft Deutscher Metallhutten­ und Bergleute) and IMM (the Institution of Mining and Metallurgy). 'EMC '91' is the first of an intended major series organized at the European level with the aim of bringing together all those who are involved with the extraction and processing of non-ferrous metals-European metallurgists and their international colleagues-to provide them with the opportunity to exchange views on the state and evolution of their industry. The programme covers all the different aspects of the metallurgy of non-ferrous metals from mining to fabricated products. Particular attention is being paid to the European non -ferrous industry with respect to changes in demand, the technology used, pressures on the environment and the competitive position of manufacturers. The contributions of the...


    African Journals Online (AJOL)

    Regulations governing the production and use of genetically modified organisms have been developed in the United Kingdom since 1976. Regulations covering the release of transgenic organisms into the environment were initially voluntary. Since 1990, the European Economic Commission (EEC) Directive. 90/219 and ...

  18. European Music Year 1985. (United States)

    Alexanderson, Thomas; And Others


    Articles concerning music are included in this newsletter dedicated to cultural venture to be jointly carried out by the Council of Europe and the European communities. Many events will mark Music Year 1985, including concerts, dance performances, operas, publications, recordings, festivals, exhibitions, competitions, and conferences on musical…

  19. Mexican oil industry: Shifting to difficult oil

    Energy Technology Data Exchange (ETDEWEB)

    Bazan G., Gerardo; Gonzalez, Cristobal J.


    Mexico has stepped into an important transition of declining oil fields and new challenging oil projects. The aim of this paper is to show a new perspective of the oil resources that have been exploited throughout the Mexican territory, as well as the remaining resources yet to be exploited. We have developed a resources/production-costs chart that illustrates the historical and future development of the Mexican oil industry, showing the shift that the industry will face in the coming years; this chart was taken from a model already in use by the most prestige energy agencies in the world.

  20. Base Oils from Petroleum (United States)

    Prince, R. J.

    The source, composition and suitability of crude oils for base oil production are reviewed. The physical and chemical properties of alkanes, naphthenes and aromatics and their characteristics for lubricant applications are examined. Properties and applications of various base oils are defined and specified. Production of conventional mineral oils is described, including the various processes to remove wax and other deleterious substances, followed by increasingly severe hydrogenation to produce base oils of increased quality and performance. The API categorization of mineral base oils, either direct from the refinery or after hydrotreatment of increasing severity, is described, together with sub-categories.

  1. Evaluation of Five Grid Datasets against Radiosonde Data over the Eastern and Downstream Regions of the Tibetan Plateau in Summer

    Directory of Open Access Journals (Sweden)

    Yuanchang Dong


    Full Text Available In this study, horizontal wind (U and V, air temperature (T, and relative humidity (RH modelled by the European Centre for Medium-Range Weather Forecasts Reanalysis Interim (ERA-Interim, the National Aeronautics and Space Administration (NASA Modern Era Retrospective Analysis for Research and Applications (MERRA, the Japanese 55-year Reanalysis (JRA-55, the National Centers for Environmental Prediction (NCEP Climate Forecast System Version 2 (CFSv2, and the NCEP Final Operational Global Analysis data and the NCEP Final Operational Global Analysis data (NCEP-FNL products have been compared with observations at 11 radiosonde stations over the eastern and downstream regions of the Tibetan Plateau (TP from late June until the end of July during 2011 to 2015. The mean bias of all variables for the five gridded datasets (GDs in the Sichuan Basin (SCB is larger than that for the TP. The mean values of U, V, and T from each grid dataset are generally consistent with the radiosonde values, whereas considerable bias in the mean RH exists at upper levels. The diurnal variation of the mean bias and root-mean-square (RMS error in the basin are stronger than those in the TP and the negative/positive peak usually occurs at 06:00 UTC and 18:00 UTC in the basin or at 12:00 UTC in the TP. The inter-annual variations in the basin are significantly stronger, and the maximum values of the variations usually occur at upper levels or near the surface, except for V. The weather conditions have a crucial influence on the performance of the gridded datasets. The mean bias and RMS error of T in the TP on cloudy days are obviously larger than those during sunny conditions. Considerable but unsteady differences occur in the mean bias and RMS error of U and V in different weather conditions. On average, the four variables in the TP are more sensible to the weather conditions.

  2. The Europeanness of European cinema: Identity, meaning, globalization


    Willems, Gertjan


    According to its editors, the aim of The Europeanness of European cinema is ‘to revisit the issue of the significance of European cinema as a category in the wake of the recent acceleration in transnational filmmaking and globalization as a whole’ (p. 7). Taking the transnational prominence of European cinema as a starting point, the anthology’s introduction presents some brief reflections about what ‘Europeanness’ – the central, overarching concept for the various chapters – has meant histor...

  3. Chemical oxidation of cable insulating oil contaminated soil

    NARCIS (Netherlands)

    Jinlan Xu,; Pancras, T.; Grotenhuis, J.T.C.


    Leaking cable insulating oil is a common source of soil contamination of high-voltage underground electricity cables in many European countries. In situ remediation of these contaminations is very difficult, due to the nature of the contamination and the high concentrations present. Chemical



    Egbuna, S.O.*, Ude, O.C., Ude, C.N.


    In search of solution to the harmful ecological problems due to toxicity and non-biodegradability posed by conventional transformer insulation oil (mineral oil), the production of transformer oil from soybean seed oil (vegetable oil) was carried out. The oil was extracted using n-hexane and was refined. The transformer oil was produced by transesterification and was characterized using American Society for Testing Material (ASTM) standard test. The solvent employed gave good yield of oil from...

  5. The effect of CD4 receptor downregulation and its downstream signaling molecules on HIV-1 latency

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Kyung-Chang [National Institute of Health, Chungbuk (Korea, Republic of); School of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Kim, Hyeon Guk [National Institute of Health, Chungbuk (Korea, Republic of); Roh, Tae-Young [Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk (Korea, Republic of); Division of Integrative Biosciences and Biotechnology, Pohang University of Science and Technology, Pohang, Gyeongbuk (Korea, Republic of); Park, Jihwan [Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Gyeongbuk (Korea, Republic of); Jung, Kyung-Min; Lee, Joo-Shil [National Institute of Health, Chungbuk (Korea, Republic of); Choi, Sang-Yun [School of Life Science and Biotechnology, Korea University, Seoul (Korea, Republic of); Kim, Sung Soon [National Institute of Health, Chungbuk (Korea, Republic of); Choi, Byeong-Sun, E-mail: [National Institute of Health, Chungbuk (Korea, Republic of)


    Research highlights: {yields} CD4 receptors were downregulated on the surface of HIV-1 latently infected cells. {yields} CD4 downstream signaling molecules were suppressed in HIV-1 latently infected cells. {yields} HIV-1 progeny can be reactivated by induction of T-cell activation signal molecules. {yields} H3K4me3 and H3K9ac were highly enriched in CD4 downstream signaling molecules. {yields} HIV-1 latency can be maintained by the reduction of downstream signaling molecules. -- Abstract: HIV-1 can establish a latent infection in memory CD4 + T cells to evade the host immune response. CD4 molecules can act not only as the HIV-1 receptor for entry but also as the trigger in an intracellular signaling cascade for T-cell activation and proliferation via protein tyrosine kinases. Novel chronic HIV-1-infected A3.01-derived (NCHA) cells were used to examine the involvement of CD4 downstream signaling in HIV-1 latency. CD4 receptors in NCHA cells were dramatically downregulated on its surface but were slightly decreased in whole-cell lysates. The expression levels of CD4 downstream signaling molecules, including P56{sup Lck}, ZAP-70, LAT, and c-Jun, were sharply decreased in NCHA cells. The lowered histone modifications of H3K4me3 and H3K9ac correlated with the downregulation of P56{sup Lck}, ZAP-70, and LAT in NCHA cells. AP-1 binding activity was also reduced in NCHA cells. LAT and c-Jun suppressed in NCHA cells were highly induced after PMA treatment. In epigenetic analysis, other signal transduction molecules which are associated with active and/or latent HIV-1 infection showed normal states in HIV-1 latently infected cells compared to A3.01 cells. In conclusion, we demonstrated that the HIV-1 latent state is sustained by the reduction of downstream signaling molecules via the downregulation of CD4 and the attenuated activity of transcription factor as AP-1. The HIV-1 latency model via T-cell deactivation may provide some clues for the development of the new

  6. Analysis of polycyclic aromatic hydrocarbons in vegetable oils combining gel permeation chromatography with solid-phase extraction clean-up

    DEFF Research Database (Denmark)

    Fromberg, Arvid; Højgård, A.; Duedahl-Olesen, Lene


    of benzo[a]pyrene levels in foods laid down by the Commission of the European Communities. A survey of 69 vegetable oils sampled from the Danish market included olive oil as well as other vegetable oils such as rapeseed oil, sunflower oil, grape seed oil and sesame oil. Levels of benzo[a]pyrene in all......A semi-automatic method for the determination of polycyclic aromatic hydrocarbons (PAHs) in edible oils using a combined gel permeation chromatography/solid-phase extraction (GPC/SPE) clean-up is presented. The method takes advantage of automatic injections using a Gilson ASPEC XL sample handling...... system equipped with a GPC column (S-X3) and pre-packed silica SPE columns for the subsequent clean-up and finally gas chromatography-mass spectrometry (GC-MS) determination. The method was validated for the determination of PAHs in vegetable oils and it can meet the criteria for the official control...

  7. Endocrine disrupting activities of surface water associated with a West Virginia oil and gas industry wastewater disposal site

    Energy Technology Data Exchange (ETDEWEB)

    Kassotis, Christopher D., E-mail: [Nicholas School of the Environment, Duke University, Durham, NC 27708 (United States); Iwanowicz, Luke R. [U.S. Geological Survey, Leetown Science Center, Fish Health Branch, 11649 Leetown Road, Kearneysville, WV 25430 (United States); Akob, Denise M.; Cozzarelli, Isabelle M.; Mumford, Adam C. [U.S. Geological Survey, National Research Program, 12201 Sunrise Valley Drive, MS 430, Reston, VA 20192 (United States); Orem, William H. [U.S. Geological Survey, Eastern Energy Resources Science Center, 12201 Sunrise Valley Drive, MS 956, Reston, VA 20192 (United States); Nagel, Susan C., E-mail: [Department of Obstetrics, Gynecology and Women' s Health, University of Missouri, Columbia, MO 65211 (United States)


    Currently, > 95% of end disposal of hydraulic fracturing wastewater from unconventional oil and gas operations in the US occurs via injection wells. Key data gaps exist in understanding the potential impact of underground injection on surface water quality and environmental health. The goal of this study was to assess endocrine disrupting activity in surface water at a West Virginia injection well disposal site. Water samples were collected from a background site in the area and upstream, on, and downstream of the disposal facility. Samples were solid-phase extracted, and extracts assessed for agonist and antagonist hormonal activities for five hormone receptors in mammalian and yeast reporter gene assays. Compared to reference water extracts upstream and distal to the disposal well, samples collected adjacent and downstream exhibited considerably higher antagonist activity for the estrogen, androgen, progesterone, glucocorticoid and thyroid hormone receptors. In contrast, low levels of agonist activity were measured in upstream/distal sites, and were inhibited or absent at downstream sites with significant antagonism. Concurrent analyses by partner laboratories (published separately) describe the analytical and geochemical profiling of the water; elevated conductivity as well as high sodium, chloride, strontium, and barium concentrations indicate impacts due to handling of unconventional oil and gas wastewater. Notably, antagonist activities in downstream samples were at equivalent authentic standard concentrations known to disrupt reproduction and/or development in aquatic animals. Given the widespread use of injection wells for end-disposal of hydraulic fracturing wastewater, these data raise concerns for human and animal health nearby. - Highlights: • Oil and gas wastewater disposal may increase endocrine disrupting activity in water. • Tested EDC activity in surface water near oil and gas wastewater injection site. • Water downstream had significantly

  8. How much room is left for European gas incumbents?

    Energy Technology Data Exchange (ETDEWEB)

    Schwark, Bastian


    In the context of the liberalization of the European natural gas market former monopolists face a challenge to react to market opening by realigning their strategies. Three major groups of companies can be identified that are capable to influence the European gas market significantly each with a distinctive competitive advantage. They consist of the historical gas incumbents, the power incumbents moving into gas as well as the integrated oil and gas producers moving downwards the supply chain by enlarging their supply division. The aim of the paper is to identify the strategic opportunities of the aforementioned three groups and to asses their success. The analysis is done by means of 22 selected companies that are highly active in the EU gas market. An assessment of their market data and comparisons between the three groups will be done. The firms will be matched according to the potential strategic groups and an outlook given in terms of the development of competition in the European gas market. The results sustain the assumption that the playing field for European gas incumbents is going to decrease as both electricity incumbents and integrated oil and gas producers have significant competitive advantages in their potential moves. (auth)

  9. Fermentation assisted byproduct recovery in the palm oil industry

    Energy Technology Data Exchange (ETDEWEB)

    Stanton, W.R.


    The production of palm oil from Elaeis guineensis is a leading natural product industry in Malaysia, giving rise to a number of residues, including a rich, fruity liquor from the pulp. The liquor, of which 7-10 million tonnes a year are currently produced, has some 6% organic solids, including 0.7-1.0% or more of oil which physical processing has failed to extract. Present anaerobic digestion processes exploit only the energy and fertiliser value. Methods are described in this paper for thermophilic, microbially assisted digestion for component separation and recovery, exploiting the widely used techniques for fruit juice extraction involving enzymic breakdown of starch, pectin and other cell components. Anaerobiosis and acidogenesis help protect and release residual oil, concomitantly preserving the solids against rancidity and spoilage by ensilage. The separated wet solids are nutritive (17% protein on dry matter), biologically safe and attractive to livestock. Downstream use of the liquor is aided by the thermophilic digestion. (Refs. 33).

  10. European core curriculum in neurorehabilitation

    NARCIS (Netherlands)

    Sandrini, G.; Binder, H.; Homberg, V.; Saltuari, L.; Tarkka, I.; Smania, N.; Corradini, C.; Giustini, A.; Katterer, C.; Picari, L.; Diserens, K.; Koenig, E.; Geurts, A.C.; Anghelescu, A.; Opara, J.; Tonin, P.; Kwakkel, G.; Golyk, V.; Onose, G.; Perennou, D.; Picelli, A.


    To date, medical education lacks Europe-wide standards on neurorehabilitation. To address this, the European Federation of NeuroRehabilitation Societies (EFNR) here proposes a postgraduate neurorehabilitation training scheme. In particular, the European medical core curriculum in neurorehabilitation

  11. European and Integration Studies

    Directory of Open Access Journals (Sweden)

    N. Yu. Kaveshnikov


    Full Text Available Soviet scientific school of pan-European integration studies began to emerge in the 1960s at the Institute of World Economy and International Relations (Russian Academy of Science. Among the leading scientists who have developed methodological approaches of Soviet integration studies were M.M. Maximova, Y.A. Borko, Y. Shishkov, L.I. Capercaillie. Later, a new center for integration studies became the Institute of Europe, created in 1987. It was led by such renowned scientists as Academicians V.V. Zhurkin and N.P. Shmelev. In the 1980s the subject of the integration process in Europe attracted attention of experts from MGIMO. An important role in the development of school of integration research in the USSR was played by a MGIMO professor, head of the chair of history of international relations and foreign policy of the USSR V.B. Knyazhinskiy. His work contributed to the deliverance of the national scientific community from skepticism about the prospects for European integration. Ideas of V.B. Knyazhinsky are developed today in MGIMO by his followers A.V. Mal'gin and T.V. Ur'eva. In the mid-1990s, having retired from diplomatic service, professor Yu. Matveevskiy started to work at MGIMO. With a considerable practical experience in the field, he produced a series of monographs on the history of European integration. In his works, he analyses the development of integration processes in Western Europe from their inception to the present day, showing the gradual maturation of the necessary spiritual and material prerequisites for the start of integration and traces the various stages of the "integration". In the late 1990s, the growing demand from the domestic business and government for professionals who are capable of interacting with the European Union, has produced the necessary supply in the form of educational programs based on accumulated scientific knowledge. Setting up a discipline "European Integration" was a major step in the development

  12. Sassafras oil overdose (United States)

    ... oil. It is a clear or slightly yellow oily liquid. It can be dangerous in large amounts. ... breathing Shallow breathing NERVOUS SYSTEM Dizziness Hallucinations Unconsciousness SKIN Burns (if the oil is on the skin)

  13. Oil market outlook

    NARCIS (Netherlands)

    Lorié, J.; Kastelein, M.; Zeilstra, A.


    The price of oil has a huge impact on the profitability of many and varied industries. In this report, we explore the factors that affect that price and look at the likely future development of the oil market.

  14. Vegetable Oil-Biorefinery. (United States)

    Pudel, Frank; Wiesen, Sebastian


    Conventional vegetable oil mills are complex plants, processing oil, fruits, or seeds to vegetable fats and oils of high quality and predefined properties. Nearly all by-products are used. However, most of the high valuable plant substances occurring in oil fruits or seeds besides the oil are used only in low price applications (proteins as animal feeding material) or not at all (e.g., phenolics). This chapter describes the state-of-the-art of extraction and use of oilseed/oil fruit proteins and phyto-nutrients in order to move from a conventional vegetable oil processing plant to a proper vegetable oil-biorefinery producing a wide range of different high value bio-based products.

  15. Extraction and purification methods in downstream processing of plant-based recombinant proteins. (United States)

    Łojewska, Ewelina; Kowalczyk, Tomasz; Olejniczak, Szymon; Sakowicz, Tomasz


    During the last two decades, the production of recombinant proteins in plant systems has been receiving increased attention. Currently, proteins are considered as the most important biopharmaceuticals. However, high costs and problems with scaling up the purification and isolation processes make the production of plant-based recombinant proteins a challenging task. This paper presents a summary of the information regarding the downstream processing in plant systems and provides a comprehensible overview of its key steps, such as extraction and purification. To highlight the recent progress, mainly new developments in the downstream technology have been chosen. Furthermore, besides most popular techniques, alternative methods have been described. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Downstream management practices of transnational companies in institutionally vulnerable countries: Export and use of hazardous products

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Milanez, Bruno


    Analyses of social and environmental management in transnational product chains focus often upstream on suppliers in socially and institutionally vulnerable countries and these suppliers' hazardous processes. Furthermore focus is on transnational companies' responsibility when they source from...... such suppliers. On the contrary, not much focus has been on transnational companies' downstream export of hazardous products to vulnerable countries and the product use in those countries. The article uses pesticides as case of hazardous products and identifies mechanisms in the downstream social...... and environmental management of a Danish pesticide company in vulnerable countries and especially in Brazil. The identified mechanisms are: the transnational company's on-going interpretation of the regulatory and ethical obligations for development and use of its hazardous products in vulnerable countries, path...

  17. Physical modeling of the flow downstream of the butterfly valve of a carburetor

    Energy Technology Data Exchange (ETDEWEB)

    Lahbabi, F.Z.; Nuglish, H.J.; Couteau, G.; Charnay, G. (Institut de Mecanique des Fluides de Toulouse, Toulouse (France))


    The flow downstream of the carburetor of a spark ignition piston-engine was experimentally investigated, the geometry was simplified, and single-phase flow was used. Experiments were carried out in a straight cylindrical tube in which a butterfly valve was mounted. Tests were made with water and air. Qualitative and quantitative flow-visualization techniques and hot wire anemometry were used. The existence of several zones of low downstream of the valve was shown by local velocity measurements and measurement of three-dimensional particle trajectories. These results permitted estimation of the location of regions with high, medium, and low rates of deposition of fuel droplets on the walls under actual operating conditions of engines.

  18. A novel cell autolysis system for cost-competitive downstream processing. (United States)

    Hajnal, Ivan; Chen, Xiangbin; Chen, Guo-Qiang


    The industrial production of low value-added biological products poses significant challenges due to cost pressures. In recent years, it has been argued that synthetic biology approaches will lead to breakthroughs that eliminate price bottlenecks for the production of a wide range of biological products including bioplastics and biofuels. One significant bottleneck lies in the necessity to break the tough cell walls of microbes in order to release intracellular products. We here report the implementation of the first synthetic biology standard part based on the lambda phage SRRz genes and a synthetic ribosome binding site (RBS) that works in Escherichia coli and Halomonas campaniensis, which enables the producer strains to induce lysis after the addition of small amounts (1-5 %) of solvents or to spontaneously lyse during the stresses of downstream processing, and thus has the potential to eliminate the mechanical cell disruption step as both an efficiency bottleneck and a significant capex barrier when implementing downstream bioprocesses.

  19. Eutrophication downstream from small reservoirs in mountain rivers of Central Spain. (United States)

    Camargo, Julio A; Alonso, Alvaro; de la Puente, Marcos


    In this research we examined the hypothesis that upper reaches of rivers and streams can experience eutrophication as a consequence of deep releases from dams. Field studies were conducted in four mountain rivers (Tormes, Riaza, Eresma and Miraflores Rivers) of Central Spain. The watersheds of these rivers are underlain by siliceous rocks. A small deep-release storage reservoir is found in the upper reaches of each river. Two sampling sites, upstream and downstream from the reservoir, were established in stony riffles of each impounded river. Significant (P rivers, can act as nutrient sources, causing eutrophication downstream. Nutrients would ultimately come from land/forest runoff. The fact that terrestrial vegetation was not completely removed before filling reservoirs could also contribute to the eutrophication process.

  20. Analysis of velocity fluctuations downstream of a bileaflet mechanical heart valve (United States)

    Forleo, Marcio; Dasi, Lakshmi


    Bileaflet mechanical heart valves are widely used to replace diseased aortic heart valves. The stresses induced by the rich and unsteady non-physiological flow structures have been the focus to evaluate red blood cells damage and platelet activation, develop flow control strategies, or improve valve designs. In this study, we analyzed the flow fields obtained downstream of a bileaflet mechanical heart valve using time-resolved particle image velocimetry under pulsatile and steady flow conditions. Our study demonstrates the rich dynamics downstream of the valve and weighs the relevance of unsteady effects vs inertia effects on the different flow structures. Power spectrum analyses of the turbulent fluctuations highlight the highly anisotropic influence and the limited applicability of classical self-similar turbulence theory in describing the small-scale structures in the immediate vicinity of the valve.

  1. Regulating water extraction in a river basin with upstream-downstream communities

    DEFF Research Database (Denmark)

    Graversen, Mette Kildegaard

    This paper proposes a tax mechanism modelled for water extraction in a river system with upstream and downstream farmers. The tax mechanism is based on the regulator’s own estimation of aggregate extraction and for that reason the tax addresses the problem of asymmetric information....... It is demonstrated that the tax mechanism ensures approximately correct marginal extraction incentives for the individual farmer. Consequently, it is concluded that the tax mechanism proposed here has a practical application....

  2. Suitability of air sampling locations downstream of bends and static mixing elements. (United States)

    McFarland, A R; Gupta, R; Anand, N K


    The revised standard for sampling effluent air from stacks and ducts of the nuclear industry places limits on the non-uniformity of velocity and contaminant profiles at the sampling location; namely, the coefficients of variation must not exceed 20% over an area that encompasses at least the center 2/3 of the cross sectional area. Tests were conducted to characterize the degree of mixing at downstream locations as affected by several types of flow disturbances, including 90 degree elbows and commercial static mixing devices. Flow straighteners were incorporated into the ducting upstream of the mixer to be tested to simulate the dampening of flow turbulence that might occur because of upstream HEPA filters. The coefficients of variation of velocity and tracer gas concentration measured in a straight tube at a distance of 3 diameters downstream from a 90 degree elbow were 17% and 69%, respectively. The mixing is impacted by the upstream flow turbulence. Without a flow straightener, the tracer gas concentration coefficient of variation was reduced to 33% at the 3-diameter location. The use of static mixing elements can greatly enhance the mixing process. A ring placed just downstream of a 90 degree elbow, which blocks the outer 56% of the cross sectional area, results in a coefficient of variation of 19% for tracer gas concentration at the 3-diameter location. Pressure loss across the elbow with the ring is about nine times that of the basic elbow. One of the commercially available static mixers provides coefficients of variation that are less than 10% for both velocity and tracer gas concentration at 4 diameters downstream from the mixer with a pressure loss that is only about 3.5 times as large as that of a 90 degree elbow.

  3. Production of structured lipids: acyl migration during enzymatic interesterification and downstream processing

    DEFF Research Database (Denmark)

    Xu, Xuebing


    -2 position or sn-1,3 positions of glycerol backbone. These kinds of lipids are reported to be promising for both enteral and parenteral nutrition. However, acyl migration occurs in the reaction stage and downstream purification process. This side-reaction causes by-products which are harmful...... to the required products. In this paper, the reasons of acyl migration and factors affecting the acyl migration were reviewed and discussed. The possible solutions were also evaluated....

  4. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways


    Zhang, Siyuan; Huang, Wen-Chien; Li, Ping; Guo, Hua; Poh, Say-Bee; Brady, Samuel W.; Xiong, Yan; Tseng, Ling-Ming; Li, Shau-Hsuan; Ding, Zhaoxi; Sahin, Aysegul A.; Esteva, Francisco J; Hortobagyi, Gabriel N.; Yu, Dihua


    Trastuzumab is a successful rationally designed ERBB2-targeted therapy. However, about half of individuals with ERBB2-overexpressing breast cancer do not respond to trastuzumab-based therapies, owing to various resistance mechanisms. Clinically applicable regimens for overcoming trastuzumab resistance of different mechanisms are not yet available. We show that the nonreceptor tyrosine kinase c-SRC (SRC) is a key modulator of trastuzumab response and a common node downstream of multiple trastu...

  5. SWAT Model Prediction of Phosphorus Loading in a South Carolina Karst Watershed with a Downstream Embayment (United States)

    Devendra M. Amatya; Manoj K. Jha; Thomas M. Williams; Amy E. Edwards; Daniel R.. Hitchcock


    The SWAT model was used to predict total phosphorus (TP) loadings for a 1555-ha karst watershed—Chapel Branch Creek (CBC)—which drains to a lake via a reservoir-like embayment (R-E). The model was first tested for monthly streamflow predictions from tributaries draining three potential source areas as well as the downstream R-E, followed by TP loadings using data...

  6. Scleroglucan compatibility with thickeners, alcohols and polyalcohols and downstream processing implications. (United States)

    Viñarta, Silvana C; Yossen, Mariana M; Vega, Jorge R; Figueroa, Lucía I C; Fariña, Julia I


    Thickening capacity and compatibility of scleroglucan with commercial thickeners (corn starch, gum arabic, carboxymethylcellulose, gelatin, xanthan and pectin), glycols (ethylene glycol and polyethylene glycol), alcohols (methanol, ethanol, 1-propanol and isopropanol) and polyalcohols (sorbitol, xylitol and mannitol) was explored. Exopolysaccharides (EPSs) from Sclerotium rolfsii ATCC 201126 and a commercial scleroglucan were compared. Compatibility and synergism were evaluated taking into account rheology, pH and sensory properties of different thickener/scleroglucan mixtures in comparison with pure solutions. S. rolfsii ATCC 201126 EPSs induced or increased pseudoplastic behaviour with a better performance than commercial scleroglucan, showing compatibility and synergy particularly with corn starch, xanthan, pectin and carboxymethylcellulose. Compatibility and a slight synergistic behaviour were also observed with 30% (w/v) ethylene glycol whereas mixtures with polyethylene glycol (PEG) precipitated. Scleroglucan was compatible with polyalcohols, whilst lower alcohols led to scleroglucan precipitation at 20% (v/v) and above. PEG-based scleroglucan downstream processing was compared to the usual alcohol precipitation. Downstream processed EPSi (with isopropanol) and EPS-p (with PEG) were evaluated on their yield, purity, rheological properties and visual aspect pointing to alcohol downstream processing as the best methodology, whilst PEG recovery would be unsuitable. The highest purified EPSi attained a recovery yield of ~23%, similar to ethanol purification, with a high degree of purity (88%, w/w vs. EPS-p, 8%, w/w) and exhibited optimal rheological properties, water solubility and appearance. With a narrower molecular weight distribution (M(w), 2.66×10(6) g/mol) and a radius of gyration (R(w), 245 nm) slightly lower than ethanol-purified EPSs, isopropanol downstream processing showed to be a proper methodology for obtaining a refined-grade scleroglucan

  7. Monitoring Thermal Pollution in Rivers Downstream of Dams with Landsat ETM+ Thermal Infrared Images

    Directory of Open Access Journals (Sweden)

    Feng Ling


    Full Text Available Dams play a significant role in altering the spatial pattern of temperature in rivers and contribute to thermal pollution, which greatly affects the river aquatic ecosystems. Understanding the temporal and spatial variation of thermal pollution caused by dams is important to prevent or mitigate its harmful effect. Assessments based on in-situ measurements are often limited in practice because of the inaccessibility of water temperature records and the scarcity of gauges along rivers. By contrast, thermal infrared remote sensing provides an alternative approach to monitor thermal pollution downstream of dams in large rivers, because it can cover a large area and observe the same zone repeatedly. In this study, Landsat Enhanced Thematic Mapper Plus (ETM+ thermal infrared imagery were applied to assess the thermal pollution caused by two dams, the Geheyan Dam and the Gaobazhou Dam, located on the Qingjiang River, a tributary of the Yangtze River downstream of the Three Gorges Reservoir in Central China. The spatial and temporal characteristics of thermal pollution were analyzed with water temperatures estimated from 54 cloud-free Landsat ETM+ scenes acquired in the period from 2000 to 2014. The results show that water temperatures downstream of both dams are much cooler than those upstream of both dams in summer, and the water temperature remains stable along the river in winter, showing evident characteristic of the thermal pollution caused by dams. The area affected by the Geheyan Dam reaches beyond 20 km along the downstream river, and that affected by the Gaobazhou Dam extends beyond the point where the Qingjiang River enters the Yangtze River. Considering the long time series and global coverage of Landsat ETM+ imagery, the proposed technique in the current study provides a promising method for globally monitoring the thermal pollution caused by dams in large rivers.

  8. The Shoah within European identity

    NARCIS (Netherlands)

    van der Poel, Stefan


    In the Epilogue of Postwar, titled: From the House ofthe Dead: An essay on Modern European memory, Tony Judt concludes that: ‘those who would become full Europeans in the dawn of the twenty-first century must first assume a new and far more oppressive heritage. Today the pertinent European reference

  9. Automotive gear oil lubricant from soybean oil (United States)

    The use of lubricants that are based on renewable materials is rapidly increasing. Vegetable oils have good lubricity, wear protection and low volatility which are desired properties for automotive gear lubricant applications. Soybean oil is used widely in the lubricant industry due to its properti...

  10. Crude oil desulfurization (United States)

    Kalvinskas, J. J.; Hsu, G. C.; Ernest, J. B. (Inventor)


    High sulfur crude oil is desulfurized by a low temperature (25-80 C.) chlorinolysis at ambient pressure in the absence of organic solvent or diluent but in the presence of water (water/oil=0.3) followed by a water and caustic wash to remove sulfur and chlorine containing reaction products. The process described can be practiced at a well site for the recovery of desulfurized oil used to generate steam for injection into the well for enhanced oil recovery.

  11. Future European biogas

    DEFF Research Database (Denmark)

    Meyer, A. K.P.; Ehimen, E. A.; Holm-Nielsen, J. B.


    Biogas is expected to play an important role in reaching the future energy policy targets of the European Union (EU). The sustainability of biogas substrates has however been recently critically discussed due to the increasing shares of agricultural land used for energy crop production.The aim...... were animal manure, straw by-products from cereal production, and excess grass from rotational and permanent grasslands and meadows. The biogas energy potential from the investigated biomass was projected to range from 1.2·103 to 2.3·103 PJ y-1 in year 2030 in the EU28, depending on the biomass...... availability. Alone the biogas energy potential projected in the scenario representing low substrate availability corresponds to a doubling of the European biogas production in 2015. The results shows that sustainable alternatives to the use of maize are present in all the member states of the EU28...

  12. European Patterns of Participation

    DEFF Research Database (Denmark)

    Harrebye, Silas Fehmerling; Ejrnæs, Anders


    Social Survey (ESS) Round 4 (2008), the article finds that satisfaction/dissatisfaction with the government is an important predictor alongside the institutional macro-level variable. The article combines a critical tradition, which suggests that political participation is motivated by a feeling...... of dissatisfaction with the government and feelings of being member of a discriminated group affect the level of extra-parliamentary participation, and second, how different welfare regimes condition the extend to which these groups chose to act. In a comparative multilevel design, using data from the European...... of dissatisfaction with an institutional perspective in which certain institutional conditions are seen as enablers for citizens to actively participate in political life. Our results show that the overall level of extra-parliamentary activity in the Scandinavian countries is higher than in the other European...

  13. Chestnut, European (Castanea sativa). (United States)

    Corredoira, Elena; Valladares, Silvia; Vieitez, Ana M; Ballester, Antonio


    Development of a system for direct transfer of antifungal candidate genes into European chestnut (Castanea sativa) would provide an alternative approach to conventional breeding for production of chestnut trees that are tolerant to ink disease caused by Phytophthora spp. Overexpression of genes encoding PR proteins (such as thaumatin-like proteins), which display antifungal activity, may represent an important advance in control of the disease. We have used a chestnut thaumatin-like protein gene (CsTL1) isolated from European chestnut cotyledons and have achieved overexpression of the gene in chestnut somatic embryogenic lines used as target material. We have also acclimatized the transgenic plants and grown them on in the greenhouse. Here, we describe the various steps of the process, from the induction of somatic embryogenesis to the production of transgenic plants.

  14. Do Europeans Like Nudges?

    DEFF Research Database (Denmark)

    Reisch, Lucia A.; Sunstein, Cass R.


    In recent years, many governments have shown a keen interest in “nudges” — approaches to law and policy that maintain freedom of choice, but that steer people in certain directions. Yet to date, there has been little evidence on whether citizens of various societies support nudges and nudging. We...... report the results of nationally representative surveys in six European nations: Denmark, France, Germany, Hungary, Italy, and the United Kingdom. We find strong majority support for nudges of the sort that have been adopted, or under serious consideration, in democratic nations. Despite the general...... European consensus, we find markedly lower levels of support for nudges in two nations: Hungary and Denmark. We are not, in general, able to connect support for nudges with distinct party affiliations....

  15. Pirating European Studies

    Directory of Open Access Journals (Sweden)

    Natalia Timus


    Full Text Available Open Science has gained a lot of attention not only within the academic community but also among policy-makers. Some international publishers have been active in moving towards open access publications and research data, but, overall, modest results have been achieved so far. In this context, the digital piracy engines emerge as vital actors in disseminating and determining the impact of research. This study examines the Sci-Hub downloads data in order to uncover patterns of piracy in European Studies research. We identify journals and the subjects of articles that have been pirated the most. We also study the geographical distribution of download requests. The analysis reveals that the readers are mostly interested in subjects reflecting the current major European challenges, specifically populism and the economic crisis. Both developing countries as well as the ‘old’ EU members are active in illegal downloads.

  16. Stature of early Europeans. (United States)

    Hermanussen, Michael


    The ancestors of modern Europeans arrived in Europe at least 40,000 years before present. Pre-glacial maximum Upper Palaeolithic males (before 16,000 BC) were tall and slim (mean height 179 cm, estimated average body weight 67 kg), while the females were comparably small and robust (mean height 158 cm, estimated average body weight 54 kg). Late Upper Palaeolithic males (8000-6600 BC) were of medium stature and robusticity (mean height 166 cm, estimated average body weight 62 kg). Stature further decreased to below 165 cm with estimated average body weight of 64 kg in Neolithic males of the Linear Band Pottery Culture, and to 150 cm with estimated average body weight of 49 kg in Neolithic females. The body stature of European males remained within the range of 165 to 170 cm up to the end of the 19th century.

  17. European Corporate Law

    DEFF Research Database (Denmark)

    Werlauff, Erik; Dorresteijn, Adriaan; Teichmann, Christoph

    This fully updated new edition provides the best-known practical overview of the law regarding companies, business activities, and capital markets in Europe, at both the European Union (EU) and Member State levels. It incorporates analysis of recent developments including the impact of global......; - a company’s freedom to incorporate in a jurisdiction not its own; - competition among the legal forms of different Member States; and - safeguarding of employee involvement in cross-border transactions. With respect to national law, the laws of Belgium, France, Germany, the Netherlands, Poland, Spain...... initiatives in such aspects of the corporate environment as regulation of financial institutions and non-financial reporting obligations with a view to sustainability and other social responsibility concerns. The authors, all leading experts in European corporate law, describe current and emerging trends...

  18. The Governance of Multi-Use Platforms at Sea for Energy Production and Aquaculture: Challenges for Policy Makers in European Seas

    NARCIS (Netherlands)

    Stuiver, Marian; Soma, Katrine; Koundouri, Phoebe; Burg, Van Den Sander; Gerritsen, Alwin; Rockmann, C.


    European seas are encountering an upsurge in competing marine activities and infrastructures. Traditional exploitation such as fisheries, tourism, transportation, and oil production are accompanied by new sustainable economic activities such as offshore windfarms, aquaculture, and tidal and wave

  19. Safety of snake antivenom immunoglobulins: efficacy of viral inactivation in a complete downstream process. (United States)

    Caricati, C P; Oliveira-Nascimento, L; Yoshida, J T; Caricati, A T P; Raw, I; Stephano, M A


    Viral safety remains a challenge when processing a plasma-derived product. A variety of pathogens might be present in the starting material, which requires a downstream process capable of broad viral reduction. In this article, we used a wide panel of viruses to assess viral removal/inactivation of our downstream process for Snake Antivenom Immunoglobulin (SAI). First, we screened and excluded equine plasma that cross-reacted with any model virus, a procedure not published before for antivenoms. In addition, we evaluated for the first time the virucidal capacity of phenol applied to SAI products. Among the steps analyzed in the process, phenol addition was the most effective one, followed by heat, caprylic acid, and pepsin. All viruses were fully inactivated only by phenol treatment; heat, the second most effective step, did not inactivate the rotavirus and the adenovirus used. We therefore present a SAI downstream method that is cost-effective and eliminates viruses to the extent required by WHO for a safe product. © 2013 American Institute of Chemical Engineers.

  20. Measurement of pulsatile turbulent flow downstream of polyurethane heart valve prosthesis using particle image velocimetry

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J.K.; Sung, J.Y. [Graduate School, Seoul National University, Seoul (Korea); Chang, J.K.; Min, B.G.; Yoo, J.Y. [Seoul National University, Seoul (Korea)


    In-vitro flow characteristics downstream of a polyurethane artificial heart valve under a pulsatile flow condition were investigated using Particle Image Velocimetry (PIV). With a triggering system and a time-delay circuit the velocity field downstream of the valve was evaluated in conjunction with the opening behavior of a flexible valve leaflet during a cardiac cycle.. Reynolds shear stress distribution was calculated from the velocity fields at a peak systolic phase. Direct measurements of the wall shear stress by hot-film anemometry (HFA) were compared with the PIV data. The possibilities of vascular complications, such as the thrombus formation and red blood cell damage, could be estimated from the overall view of the instantaneous velocity and stress fields obtained. A correlation between the flow pattern downstream of the valve and the corresponding opening posture of the polyurethane valve membrane gives useful data necessary for the improved design of the frame structure and leaflet geometry of the valve. (author). 11 refs., 8 figs., 5 tabs.

  1. Optimizing withdrawal from drinking water reservoirs to reduce downstream temperature pollution and reservoir hypoxia. (United States)

    Weber, M; Rinke, K; Hipsey, M R; Boehrer, B


    Sustainable management of drinking water reservoirs requires balancing the demands of water supply whilst minimizing environmental impact. This study numerically simulates the effect of an improved withdrawal scheme designed to alleviate the temperature pollution downstream of a reservoir. The aim was to identify an optimal withdrawal strategy such that water of a desirable discharge temperature can be supplied downstream without leading to unacceptably low oxygen concentrations within the reservoir. First, we calibrated a one-dimensional numerical model for hydrodynamics and oxygen dynamics (GLM-AED2), verifying that the model reproduced water temperatures and hypolimnetic dissolved oxygen concentrations accurately over a 5 year period. Second, the model was extended to include an adaptive withdrawal functionality, allowing for a prescribed withdrawal temperature to be found, with the potential constraint of hypolimnetic oxygen concentration. Scenario simulations on epi-/metalimnetic withdrawal demonstrate that the model is able to autonomously determine the best withdrawal height depending on the thermal structure and the hypolimnetic oxygen concentration thereby optimizing the ability to supply a desirable discharge temperature to the downstream river during summer. This new withdrawal strategy also increased the hypolimnetic raw water volume to be used for drinking water supply, but reduced the dissolved oxygen concentrations in the deep and cold water layers (hypolimnion). Implications of the results for reservoir management are discussed and the numerical model is provided for operators as a simple and efficient tool for optimizing the withdrawal strategy within different reservoir contexts. Copyright © 2017 Elsevier Ltd. All rights reserved.

  2. Environmental hedging: A theory and method for reconciling reservoir operations for downstream ecology and water supply (United States)

    Adams, L. E.; Lund, J. R.; Moyle, P. B.; Quiñones, R. M.; Herman, J. D.; O'Rear, T. A.


    Building reservoir release schedules to manage engineered river systems can involve costly trade-offs between storing and releasing water. As a result, the design of release schedules requires metrics that quantify the benefit and damages created by releases to the downstream ecosystem. Such metrics should support making operational decisions under uncertain hydrologic conditions, including drought and flood seasons. This study addresses this need and develops a reservoir operation rule structure and method to maximize downstream environmental benefit while meeting human water demands. The result is a general approach for hedging downstream environmental objectives. A multistage stochastic mixed-integer nonlinear program with Markov Chains, identifies optimal "environmental hedging," releases to maximize environmental benefits subject to probabilistic seasonal hydrologic conditions, current, past, and future environmental demand, human water supply needs, infrastructure limitations, population dynamics, drought storage protection, and the river's carrying capacity. Environmental hedging "hedges bets" for drought by reducing releases for fish, sometimes intentionally killing some fish early to reduce the likelihood of large fish kills and storage crises later. This approach is applied to Folsom reservoir in California to support survival of fall-run Chinook salmon in the lower American River for a range of carryover and initial storage cases. Benefit is measured in terms of fish survival; maintaining self-sustaining native fish populations is a significant indicator of ecosystem function. Environmental hedging meets human demand and outperforms other operating rules, including the current Folsom operating strategy, based on metrics of fish extirpation and water supply reliability.


    Directory of Open Access Journals (Sweden)

    Xiaohui Xu


    Full Text Available Abstract In the production of chemicals from fermentation, the cost of downstream purification constitutes the major portion of the total production cost. Since the bioprocess generally contains a large amount of biochemical separation units, its flowsheets are complex. How to generate the rigorous superstructure of the downstream bioprocess is a primary problem and key step. In this work, a robust combined approach based on the P-graph was proposed to generate the rigorous superstructure of the downstream process of fermentation. This method integrates the hierarchical decomposition of the heuristics with P-graph-based algorithm MSG with the advantages including: (1 Different design flowsheets could be evaluated simultaneously; (2 An unique bipartite graph, P-graph, was introduced, which could represent the maximum structure clearly and intuitively; (3 The rigorous superstructure could be automatically generated. The validity of the present method was verified with two practical bioprocesses. Results show that the effective processes and the adequate operation units could be determined in the beginning stage of the design, and the tedious reforming steps during process synthesis could be avoided.

  4. Glycosaminoglycan-Mediated Downstream Signaling of CXCL8 Binding to Endothelial Cells

    Directory of Open Access Journals (Sweden)

    Rupert Derler


    Full Text Available The recruitment of leukocytes, mediated by endothelium bound chemokine gradients, is a vital process in inflammation. The highly negatively charged, unbranched polysaccharide family of glycosaminoglycans (GAGs, such as heparan sulfate and chondroitin sulfate mediate chemokine immobilization. Specifically the binding of CXCL8 (interleukin 8 to GAGs on endothelial cell surfaces is known to regulate neutrophil recruitment. Currently, it is not clear if binding of CXCL8 to GAGs leads to endothelial downstream signaling in addition to the typical CXCR1/CXCR2 (C-X-C motif chemokine receptor 1 and 2-mediated signaling which activates neutrophils. Here we have investigated the changes in protein expression of human microvascular endothelial cells induced by CXCL8. Tumor necrosis factor alpha (TNFα stimulation was used to mimic an inflammatory state which allowed us to identify syndecan-4 (SDC4 as the potential proteoglycan co-receptor of CXCL8 by gene array, real-time PCR and flow cytometry experiments. Enzymatic GAG depolymerization via heparinase III and chondroitinase ABC was used to emulate the effect of glycocalyx remodeling on CXCL8-induced endothelial downstream signaling. Proteomic analyses showed changes in the expression pattern of a number of endothelial proteins such as Zyxin and Caldesmon involved in cytoskeletal organization, cell adhesion and cell mobility. These results demonstrate for the first time a potential role of GAG-mediated endothelial downstream signaling in addition to the well-known CXCL8-CXCR1/CXCR2 signaling pathways in neutrophils.

  5. Upstream to downstream: stormwater quality in Mayagüez, Puerto Rico. (United States)

    Wengrove, Meagan E; Ballestero, Thomas P


    The focus of this research was upon consequences of urban stormwater runoff entering two streams in Mayagüez, Puerto Rico. Mayagüez is the largest urban area of the western side of the island of Puerto Rico and provides an excellent point of reference to monitor the affects of urban development on water quality in a tropical climate. The two monitored streams were Quebrada del Oro and Cano Majagual. The research hypothesis asks, "Does stormwater runoff from urban development measurably affect the water quality of downstream receiving water by raising the conductivity, temperature, and flow quantity characteristics during storm events in comparison to upstream water quality?" In essence, the results for Quebrada del Oro agreed with the hypothesis of this project, while Cano Majagual produced results different from the hypothesis primarily due to the absence of non-urbanized land use for both upstream and downstream sections as well as the buffering capacity of a large wetland just upstream of the downstream instrument location of Cano Majagual. Both streams showed signs of stream impairment according to the temperature criteria (32°C or 90°F) set by the Junta de Calidad Ambiental and the US Environmental Protection Agency. Dissolved oxygen levels of the streams were severely affected by water temperature and oxygen-consuming matter within these stream systems, making dissolved oxygen and temperature important water quality parameters for tropical climates.

  6. Zooplankton (Cladocera, Copepoda dynamics in the River Danube upstream and downstream of Budapest, Hungary

    Directory of Open Access Journals (Sweden)

    Vadadi-Fülöp, Cs.


    Full Text Available The spatial distribution and seasonal dynamics of zooplankton (Cladocera, Copepoda were studied in the River Danube near Budapest, Hungary. The investigated river section was relatively poor in plankton, nauplii dominated. A total of 36 species was recorded of which Acanthocyclops robustus, Thermocyclops crassus, Bosmina longirostris were the most abundant. There was a downstream increase in copepod densities, however, no other remarkable differences could be observed between the profiles upstream and downstream of the capital. Generally, the streamline was characterized by lower densities and lower number of taxa as compared to the river bank; nevertheless, there were differences between the left and the right banks both upstream or downstream as well. Seasonal dynamics was defined by a marked late winter–spring aspect and abundance peaks were found to be characteristic for Danube with high densities in May–June and August–September. Examining the relationship between zooplankton density and the hydrological regime, it can be concluded that zooplankton production in the main channel is of minor importance, rather floodplain areas and adjacent water bodies seem to be important sources of plankton biomass.

  7. Lost in Development’s Shadow: The Downstream Human Consequences of Dams

    Directory of Open Access Journals (Sweden)

    Brian D. Richter


    Full Text Available The World Commission on Dams (WCD report documented a number of social and environmental problems observed in dam development projects. The WCD gave particular emphasis to the challenges of properly resettling populations physically displaced by dams, and estimated the total number of people directly displaced at 40-80 million. Less attention has been given, however, to populations living downstream of dams whose livelihoods have been affected by dam-induced alterations of river flows. By substantially changing natural flow patterns and blocking movements of fish and other animals, large dams can severely disrupt natural riverine production systems – especially fisheries, flood-recession agriculture and dry-season grazing. We offer here the first global estimate of the number of river-dependent people potentially affected by dam-induced changes in river flows and other ecosystem conditions. Our conservative estimate of 472 million river-dependent people living downstream of large dams along impacted river reaches lends urgency to the need for more comprehensive assessments of dam costs and benefits, as well as to the social inequities between dam beneficiaries and those potentially disadvantaged by dam projects. We conclude with three key steps in dam development processes that could substantially alleviate the damaging downstream impacts of dams.

  8. An experimental study on the onset of detonation downstream of a perforated plate with staggered orifices (United States)

    Lin, Wei; Zhou, Jin; Lin, Zhiyong; Liu, Shijie


    The present study investigated the onset of detonation (OD) process which takes place downstream of a 0.9-mm-thick perforated plate. The orifice diameter of the plate is 1.6 mm with a blockage of 59%, and it was placed perpendicular to the axial direction of a smooth detonation tube. `Stable' mixture C2H2 + 2.5O2 + 70%Ar and `unstable' mixture C2H2 + 5N2O were tested, respectively. Ionization probes and smoked foils were used to record detonation velocities and corresponding cellular patterns. Excellent agreement of the velocity trends and smoked foil results shows that a critical pressure range exists to identify `go' and `no go' of OD downstream of the perforated plate. However, the OD mechanisms for these two gaseous mixtures are distinct: for the `stable' mixture, OD occurs in the downstream near field (6 tube diameters in this study), whereas, OD in the `unstable' mixture could also observed in the far field via the transition of deflagration to detonation after a long duration of quasi-steady regime. This distance reaches up to tens of tube diameters when close to the critical pressure.

  9. Decabrominated diphenyl ether in river fish and sediment samples collected downstream an industrial park. (United States)

    Eljarrat, Ethel; Labandeira, Ana; Marsh, Göran; Raldúa, Demetrio; Barceló, Damià


    Fish, sediment and water samples from different places along the Spanish River Vero, a tributary of the Cinca River in the Ebro River basin, were collected in two different sampling campaigns, the first one during November 2004 and the second one in November 2005. The samples were collected up- and downstream from an industrial park. A total of 29 fishes, 6 sediments and 3 water samples were analyzed for polybrominated diphenyl ethers (PBDEs). Analytical work included 23 congeners, from tri- to deca-BDEs. The highest values for both sediment and fish samples were found downstream of the industrial park. High BDE-209 contamination was found in these sediment samples, with values up to 12 microg g(-1) dry weight. Moreover, BDE-209 was detected in 14 out of 15 biota samples collected downstream the industrial park, at concentration levels ranging from 20 to 707 ng g(-1) lipid weight, whereas it was not detected in samples collected upstream. These fish concentrations proved the bioavailability of BDE-209 and represented the highest deca-BDE values found in aquatic biota. The analysis of industrial effluents revealed that some industries contribute in some way to the BDE-209 contamination found in this area, but the industry focused on the polyamide polymerization is the main responsible.

  10. Epigenetic silencing of downstream genes mediated by tandem orientation in lung cancer. (United States)

    Kiehl, Steffen; Zimmermann, Tobias; Savai, Rajkumar; Pullamsetti, Soni S; Seeger, Werner; Bartkuhn, Marek; Dammann, Reinhard H


    Epigenetic deregulation is of importance in tumorigenesis. In particular CpG islands (CGI), are frequently hypermethylated. Here, genome-wide DNA-methylation profiles of 480,000 CpGs in lung cancer cells were generated. It was observed that intra- and intergenic CGI exhibited higher methylation compared to normal cells. The functional annotation of hypermethylated CGI revealed that the hypermethylation was associated with homeobox domain genes and targets marked by repressive histone modifications. The strongest methylation variation was observed in transitional areas of CGI, termed shores. 5'-shores of promoter-associated CGI in lung cancer cell lines were higher methylated than 3'-shores. Within two tandem-oriented genes, a significant hypermethylation of the downstream-located CGI promoters was revealed. Hypermethylation correlates with the length of the intergenic region between such tandem genes. As the RASSF1A tumor suppressor gene represents such a downstream tandem gene, its silencing was analyzed using an inducible system. It was determined that the induction of an upstream gene led to a repression of RASSF1A through a process involving histone deacetylases and CPSF1. A tumor-specific increase in expression of histone deacetylases and CPSF1 was detected in lung cancer. Our results suggest that the downstream gene could be susceptible to epigenetic silencing when organized in a tandem orientation.

  11. Morphology analysis in middle-downstream area of Progo River due to the debris flow (United States)

    Fitriadin, Ahmad Azmi; Ikhsan, Jaza'ul; Harsanto, Puji


    One of the problems that occur in Progo River is the formation of sediment in the downstream section. The sediment material in the upstream becomes the source of sediment at the downstream area. Excess sediment supply from the upstream causes morphological changes in a relatively short time. The morphological changes in riverbed will affect hydraulics conditions. Hydraulic has an important role in the process of aggradation and degradation in the riverbed. Furthermore, the process of erosion and sedimentation will affect the stability of the construction in the water. In Progo River, there are some buildings of infrastructure such as revetment, bridge, irrigation intake, groundsill, and weir. Based on the results of a numerical model of the hydraulic analysis system, there was approximately 87,000,000 m3 of sediment on Progo River in 2015. In fact, aggradation and degradation occurred very intensively in the middle-downstream area of Progo River. Sediment movement simulation also showed that the sediment supply of lava could prevent excessive bed degradation. Nevertheless, the absence of sediment supply will lead to bed degradation process. It indicates that the management of the sediment supply in the upstream area must be managed properly.

  12. The effect of catalyst length and downstream reactor distance on catalytic combustor performance (United States)

    Anderson, D.


    A study was made to determine the effects on catalytic combustor performance which resulted from independently varying the length of a catalytic reactor and the length available for gas-phase reactions downstream of the catalyst. Monolithic combustion catalysts from three manufacturers were tested in a combustion test rig with no. 2 diesel fuel. Catalytic reactor lengths of 2.5 and 5.4 cm, and downstream gas-phase reaction distances of 7.3, 12.4, 17.5, and 22.5 cm were evaluated. Measurements of carbon monoxide, unburned hydrocarbons, nitrogen oxides, and pressure drop were made. The catalytic-reactor pressure drop was less than 1 percent of the upstream total pressure for all test configurations and test conditions. Nitrogen oxides and unburned hydrocarbons emissions were less than 0.25 g NO2/kg fuel and 0.6 g HC/kg fuel, respectively. The minimum operating temperature (defined as the adiabatic combustion temperature required to obtain carbon monoxide emissions below a reference level of 13.6 g CO/kg fuel) ranged from 1230 K to 1500 K for the various conditions and configurations tested. The minimum operating temperature decreased with increasing total (catalytic-reactor-plus-downstream-gas-phase-reactor-zone) residence time but was independent of the relative times spent in each region when the catalytic-reactor residence time was greater than or equal to 1.4 ms.

  13. Optimization of Upstream Detention Reservoir Facilities for Downstream Flood Mitigation in Urban Areas

    Directory of Open Access Journals (Sweden)

    Thi Thuy Ngo


    Full Text Available A detention reservoir is one of the most effective engineered solutions for flood damage mitigation in urban areas. Detention facilities are constructed to temporarily store storm water and then slowly drain when the peak period has passed. This delayed drainage may coincide with upstream floods and aggravate the flood risk downstream. Optimal operation and design are needed to improve the performance of detention reservoirs for flood reduction. This study couples hydrologic simulation software (EPA-SWMM with an evolutional optimizer (extraordinary particle swarm optimization, EPSO to minimize flood damage downstream while considering the inundation risk at the detention reservoir. The optimum design and operation are applied to an urban case study in Seoul, Korea, for historical severe flooding events and designed rainfall scenarios. The optimal facilities outperform the present facilities in terms of flood damage reduction both downstream and in the detention reservoir area. Specifically, the peak water level at the detention pond under optimal conditions is significantly smaller than that of the current conditions. The comparison of the total flooded volume in the whole watershed shows a dramatic reduction of 79% in a severe flooding event in 2010 and around 20% in 2011 and in 180 min designed rainfall scenarios.

  14. MicroRNA-145 suppresses hepatocellular carcinoma by targeting IRS1 and its downstream Akt signaling

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yelin [Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Hu, Chen; Cheng, Jun [Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Chen, Binquan [Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Ke, Qinghong; Lv, Zhen; Wu, Jian [Department of Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Key Laboratory of Combined Multi-organ Transplantation, Ministry of Public Health, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China); Zhou, Yanfeng, E-mail: [Department of Anesthesiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou (China)


    Highlights: • MiR-145 expression is down-regulated in HCC tissues and inversely related with IRS1 levels. • MiR-145 directly targets IRS1 in HCC cells. • Restored expression of miR-145 suppressed HCC cell proliferation and growth. • MiR-145 induced IRS1 under-expression potentially reduced downstream AKT signaling. - Abstract: Accumulating evidences have proved that dysregulation of microRNAs (miRNAs) is involved in cancer initiation and progression. In this study, we showed that miRNA-145 level was significantly decreased in hepatocellular cancer (HCC) tissues and cell lines, and its low expression was inversely associated with the abundance of insulin receptor substrate 1 (IRS1), a key mediator in oncogenic insulin-like growth factor (IGF) signaling. We verified IRS1 as a direct target of miR-145 using Western blotting and luciferase reporter assay. Further, the restoration of miR-145 in HCC cell lines suppressed cancer cell growth, owing to down-regulated IRS1 expression and its downstream Akt/FOXO1 signaling. Our results demonstrated that miR-145 could inhibit HCC through targeting IRS1 and its downstream signaling, implicating the loss of miR-145 regulation may be a potential molecular mechanism causing aberrant oncogenic signaling in HCC.

  15. Assessing water deprivation at the sub-river basin scale in LCA integrating downstream cascade effects. (United States)

    Loubet, Philippe; Roux, Philippe; Núñez, Montserrat; Belaud, Gilles; Bellon-Maurel, Véronique


    Physical water deprivation at the midpoint level is assessed in water-related LCIA methods using water scarcity indicators (e.g., withdrawal-to-availability and consumption-to-availability) at the river basin scale. Although these indicators represent a great step forward in the assessment of water-use-related impacts in LCA, significant challenges still remain in improving their accuracy and relevance. This paper presents a methodology that can be used to derive midpoint characterization factors for water deprivation taking into account downstream cascade effects within a single river basin. This effect is considered at a finer scale because a river basin must be split into different subunits. The proposed framework is based on a two-step approach. First, water scarcity is defined at the sub-river basin scale with the consumption-to-availability (CTA) ratio, and second, characterization factors for water deprivation (CFWD) are calculated, integrating the effects on downstream sub-river basins. The sub-river basin CTA and CFWD were computed based on runoff data, water consumption data and a water balance for two different river basins. The results show significant differences between the CFWD in a given river basin, depending on the upstream or downstream position. Finally, an illustrative example is presented, in which different land planning scenarios, taking into account additional water consumption in a city, are assessed. Our work demonstrates how crucial it is to localize the withdrawal and release positions within a river basin.

  16. Telemedicine and European law. (United States)

    Callens, Stefaan


    A Directive of the European Union was first published in 2000, which dealt with telemedicine as part of its provisions. This E-Commerce Directive, as it became known, was subjected to further study which revealed some problems relative to the practice of telemedicine. Among the subjects discussed in this paper are those of privacy, data protection, free movement of services, the impact of electronic communication and ethical issues.

  17. European Automotive Congress

    CERN Document Server

    Clenci, Adrian


    The volume includes selected and reviewed papers from the European Automotive Congress held in Bucharest, Romania, in November 2015. Authors are experts from research, industry and universities coming from 14 countries worldwide. The papers are covering the latest developments in fuel economy and environment, automotive safety and comfort, automotive reliability and maintenance, new materials and technologies, traffic and road transport systems, advanced engineering methods and tools, as well as advanced powertrains and hybrid and electric drives.

  18. Enhanced Warming with Atmospheric Blocking over European Region during Winter (United States)

    Ji, M.; Huang, J.; He, Y.


    A 62-yr (1948-2009) atmospheric blocking climatology over European region during winter is presented. The blocking activity in the European region shows a downward long-term trend. The relationship between blocking index and teleconnection patterns (TCPs) are examined. The statistical result shows the SCAND and the EA patterns can significant effect the blocking, approximately 40% of the blocking frequency variation can be explained by these two patterns. The frequency of European blocking is sensitive to the phase of the SCAND and EA. The average number of blocking days is 46 days during the positive phase of the SCAND which is twice higher than during the negative phase (18). During the negative phase of the EA, the average number of blocking days is 32, which is 54% greater during the negative phase of the EA than during the positive phase (21). The duration of the European blocking is also sensitive to the phase of the SCAND, but isn't sensitive for the EA. The 500 hPa geopotential height composite analysis also shows an evidence of a statistical relationship between the TCPs and blocking, showing that the positive (negative) phase of the SCAND (EA) provides the right conditions for the formation and sustenance of blocking activity over the European region. However, the blocking centers are located at Scandinavia and the Urals with positive of the SCAND and Siberia with negative of the EA. Finally, the downstream surface air temperature (SAT) impact associated with European winter blocking is discussed. The result shows that the SAT of Eurasian continent is significant different between high blocking index winters and low blocking index winters.

  19. Complex biallelic IGH rearrangements in IgM-expressing Z-138 cell line : Involvement of downstream immunoglobulin class switch recombination

    NARCIS (Netherlands)

    Guikema, JEJ; Fenton, JAL; de Boer, C; Kleiverda, K; Brink, AATP; Raap, AK; Estrov, Z; Schuuring, E; Kluin, PM

    Chromosomal translocations involving the immunoglobulin (Ig) receptor loci usually disrupt and silence these loci. On the basis of observations in follicular lymphoma (FL) with downstream Ig heavy chain (IGH) class switch recombination (CSR), we hypothesized that downstream CSR-mediated chromosomal

  20. Geography of European Migration

    Directory of Open Access Journals (Sweden)

    Zhitin Dmitry V.


    Full Text Available In recent decades, the role of international migration has increased dramatically in most European countries. The growth in migration has made some authors proclaim the beginning of a second Migration Period that could transform the social and cultural identity of Europe. The article presents an analysis of international migration geography in Europe in the last twenty-five years. The authors identify the main trends in migration, provide migration profiles of European countries, and propose a classification based on the recent changes in the migrant stock. Changes in the migrant stock (total emigration and immigration reflect the level of involvement in international and global processes. They can serve as an indicator of a country’s attractiveness for both foreigners and the country’s citizens. The study shows that European countries are increasingly split into ‘immigrant’ and ‘emigrant’ states. The authors describe spatial patterns of migration. The volume and localisation of migration flows in Europe are affected not only by cultural and historical circumstance, such as a colonial past or a common language. The scale of immigrant influx often does not depend on a donor country’s demographic potential or the level of its socio-economic development. The links between the place of origin and destination are often more complex than it might initially seem. The authors stress the importance of a differentiated immigration policy taking into account ethnic and cultural features of host societies.

  1. Oil Spill Cleanup (United States)

    Kauble, Christena Ann


    Several classroom activities using a model of a seashore and an oil spill demonstrate the basic properties of oil spills in oceans. Students brainstorm about how to best clean up the mess. They work in teams, and after agreeing on how they will proceed, their method is tested by measuring the amount of oil removed and by rating the cleanliness of…

  2. Oil Spill Response Manual

    NARCIS (Netherlands)

    Sandra Heins; Marieke Zeinstra; Wierd Koops


    A two year programme has been carried out by the NHL University of Applied Sciences together with private companies in the field of oil and chemical spill response to finalize these manuals on oil and chemical spill response. These manuals give a good overview of all aspects of oil and chemical

  3. Cod Liver Oil (United States)

    Cod liver oil can be obtained from eating fresh cod liver or by taking supplements. Cod liver oil is used as a source of vitamin ... condition called macular degeneration. Some people put cod liver oil on their skin to speed healing of ...

  4. Oil palm: domestication achieved?

    NARCIS (Netherlands)

    Gerritsma, W.; Wessel, M.


    The natural habitat of the oil palm comprises very wet and relatively dry niches in the lowland rain forest in West and Central Africa. The domestication of the oil palm started with the extraction of fruits from wild forest resources. When forests were cleared for shifting cultivation, oil palms


    Directory of Open Access Journals (Sweden)

    Mariana, BUICAN


    Full Text Available Oil (called by some black gold has not always been as coveted and used, but only in the last hundred years has established itself as a highly sought after as an indispensable proper functioning of modern economic activity that an important factor in international politics. International oil regime has changed in the last decades. In 1960, oil regime was a private oligopol which had links with governments main consuming countries. By then the price of a barrel of oil was two U.S. dollars and seven major transnational oil companies decided the amount of oil that will be produced. Meanwhile the world region with the largest oil exports were more strongly expressed nationalism and decolonization. Result, it was so in the late 60s in the region occur independent states. They have created an organization aim of this resource to their advantage - OPEC (Organization of Petroleum Exporting Countries. Thus since 1973 there have been changes in the international regime governing oil field, namely producing countries were fixed production rate and price. After this time the oil weapon has become increasingly important in the management of international relations. Oil influenced the great powers to Middle East conflicts that occurred in the last century, but their attitude about the emergence of new sources of oil outside OPEC. In the late 90's, Russia has become a major supplier of oil to the West.

  6. efficacy of olive oil, groundnut oil, soybean oil and palm kernel oil

    African Journals Online (AJOL)


    against C. maculatus in laboratory bioassays. However Singh et al. (1978) reported that groundnut oil applied to cowpeas has no effect on mortality or longevity of adult C. maculatus. Tikku et al. (1981) similarly showed that topical application of several vegetable oils, including groundnut and coconut oils, had no effect on ...

  7. SAR observation and model tracking of an oil spill event in coastal waters

    DEFF Research Database (Denmark)

    Cheng, Yongcun; Li, Xiaofeng; Xu, Qing


    Oil spills are a major contributor to marine pollution. The objective of this work is to simulate the oil spill trajectory of oil released from a pipeline leaking in the Gulf of Mexico with the GNOME (General NOAA Operational Modeling Environment) model. The model was developed by NOAA (National...... Oceanic and Atmospheric Administration) to investigate the effects of different pollutants and environmental conditions on trajectory results. Also, a Texture-Classifying Neural Network Algorithm (TCNNA) was used to delineate ocean oil slicks from synthetic aperture radar (SAR) observations. During...... the European ENVISAT ASAR (Advanced Synthetic Aperture Radar) and the Japanese ALOS (Advanced Land Observing Satellite) PALSAR (Phased Array L-band Synthetic Aperture Radar) images. Based on experience with past marine oil spills, about 63.0% of the oil will float and 18.5% of the oil will evaporate...

  8. Coarse and fine sediment transportation patterns and causes downstream of the Three Gorges Dam (United States)

    Li, Songzhe; Yang, Yunping; Zhang, Mingjin; Sun, Zhaohua; Zhu, Lingling; You, Xingying; Li, Kanyu


    Reservoir construction within a basin affects the process of water and sediment transport downstream of the dam. The Three Gorges Reservoir (TGR) affects the sediment transport downstream of the dam. The impoundment of the TGR reduced total downstream sediment. The sediment group d≤0.125 mm (fine particle) increased along the path, but the average was still below what existed before the reservoir impoundment. The sediments group d>0.125 mm (coarse particle) was recharged in the Yichang to Jianli reach, but showed a deposition trend downstream of Jianli. The coarse sediment in the Yichang to Jianli section in 2003 to 2007 was above the value before the TGR impoundment. However, the increase of both coarse and fine sediments in 2008 to 2014 was less than that in 2003 to 2007. The sediment retained in the dam is the major reason for the sediment reduction downstream. However, the retention in different river reaches is affected by riverbed coarsening, discharge, flow process, and conditions of lake functioning and recharging from the tributaries. The main conclusions derived from our study are as follows: 1) The riverbed in the Yichang to Shashi section was relatively coarse, thereby limiting the supply of fine and coarse sediments. The fine sediment supply was mainly controlled by TGR discharge, whereas the coarse sediment supply was controlled by the duration of high flow and its magnitude. 2) The supply of both coarse and fine sediments in the Shashi to Jianli section was controlled by the amount of total discharge. The sediment supply from the riverbed was higher in flood years than that in the dry years. The coarse sediment tended to deposit, and the deposition in the dry years was larger than that in the flood years. 3) The feeding of the fine sediment in the Luoshan to Hankou section was mainly from the riverbed. The supply in 2008 to 2014 was more than that in 2003 to 2007. Around 2010, the coarse sediments transited from depositing to scouring that was

  9. European Law in the Making:

    DEFF Research Database (Denmark)

    Rasmussen, Morten

    the legal service of the High Authority from early on promoted a ‘constitutional’ interpretation of European law, but where the member state, as well as most legal experts, still considered European law a subset of international law. How did the Court of Justice of the ECSC manoeuvre between...... on European law in the making.......Traditionally, the Court of Justice of the European Coal and Steel Community (ECSC) has mainly been considered the somewhat dull predecessor to the more famous Court of Justice of the European Communities, which in 1963-64 ‘constitutionalised’ the Treaties of Rome with the seminal judgments of Van...

  10. Utah Heavy Oil Program

    Energy Technology Data Exchange (ETDEWEB)

    J. Bauman; S. Burian; M. Deo; E. Eddings; R. Gani; R. Goel; C.K. Huang; M. Hogue; R. Keiter; L. Li; J. Ruple; T. Ring; P. Rose; M. Skliar; P.J. Smith; J.P. Spinti; P. Tiwari; J. Wilkey; K. Uchitel


    The Utah Heavy Oil Program (UHOP) was established in June 2006 to provide multidisciplinary research support to federal and state constituents for addressing the wide-ranging issues surrounding the creation of an industry for unconventional oil production in the United States. Additionally, UHOP was to serve as an on-going source of unbiased information to the nation surrounding technical, economic, legal and environmental aspects of developing heavy oil, oil sands, and oil shale resources. UHOP fulGilled its role by completing three tasks. First, in response to the Energy Policy Act of 2005 Section 369(p), UHOP published an update report to the 1987 technical and economic assessment of domestic heavy oil resources that was prepared by the Interstate Oil and Gas Compact Commission. The UHOP report, entitled 'A Technical, Economic, and Legal Assessment of North American Heavy Oil, Oil Sands, and Oil Shale Resources' was published in electronic and hard copy form in October 2007. Second, UHOP developed of a comprehensive, publicly accessible online repository of unconventional oil resources in North America based on the DSpace software platform. An interactive map was also developed as a source of geospatial information and as a means to interact with the repository from a geospatial setting. All documents uploaded to the repository are fully searchable by author, title, and keywords. Third, UHOP sponsored Give research projects related to unconventional fuels development. Two projects looked at issues associated with oil shale production, including oil shale pyrolysis kinetics, resource heterogeneity, and reservoir simulation. One project evaluated in situ production from Utah oil sands. Another project focused on water availability and produced water treatments. The last project considered commercial oil shale leasing from a policy, environmental, and economic perspective.

  11. Olive oil adulterated with hazelnut oils: simulation to identify possible risks to allergic consumers. (United States)

    Arlorio, M; Coisson, J D; Bordiga, M; Travaglia, F; Garino, C; Zuidmeer, L; Van Ree, R; Giuffrida, M G; Conti, A; Martelli, A


    According to European Union Regulation EC 1531/2001, olive oil labelled as "extra-virgin" should be cold-pressed and contain no refined oil or oil from other oleaginous seeds or nuts. Adulteration of extra virgin olive oil (EVOO) with hazelnut oil (HAO) is a serious concern both for oil suppliers and consumers. The high degree of similarity between the two fats complicates the detection of low percentages of HAO in EVOO. Many analytical approaches have been developed in recent years to trace HAO in EVOO, principally based on chromatographic analyses, differential scanning calorimetry or nuclear magnetic resonance. In addition adulteration of EVOO with HAO may introduce hazelnut-derived allergens. The aim of this work was to analyse the protein and allergen content of EVOO intentionally spiked with raw cold-pressed HAO or solvent-extracted HAO. SDS-PAGE analysis confirmed the presence of hazelnut proteins in solvent-extracted HAO with molecular masses ranging 10-60 kDa. In contrast, cold-pressed HAO showed no traces of protein. In spiked EVOO, solvent-extracted HAO was still detectable at a 1% contamination level. Several bands on SDS-PAGE migrated at apparent molecular masses coinciding with known allergens, such as Cor a 1 (approximately 17 kDa), Cor a 2 (approximately 14 kDa), Cor a 8 (approximately 12 kDa), oleosin (approximately 17 kDa) and Cor a 9 (approximately 60 kDa). MALDI-TOF MS analysis confirmed the presence of two oleosin isoforms and of Cor a 9. Immunoblotting demonstrated that an allergic patient with known reactivity to Cor a 1 and Cor a 2 recognized a 17-kDa band in solvent-extracted HAO. In conclusion, we have shown that adulteration of extra virgin olive oil with solvent-extracted hazelnut oil can be traced by simple SDS-PAGE analysis, and that adulteration introduces a potential risk for hazelnut allergic patients.

  12. Oil on the market

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, K.; Ukert, T.


    The structure of the German mineral oil market, supply and consumption as well as the particularities of this market are investigated and explained. The authors deal in particular with the market for light fuel oil, the petrol market, the market for heavy fuel oil and the market of lubricants. As different as these markets may be - the unavoidable coupled production produces interdependences. This and the balance caused by imports and exports have the effect that the price level on the German mineral oil markets is closely connected with the development of prices on the internal mineral oil markets.

  13. Eastern Dimension of the European Neighbourhood Policy: Europeanization Mutual Trap

    Directory of Open Access Journals (Sweden)

    V. A. Latkina


    Full Text Available The article analyses the Europeanization policy of the European Union towards the Eastern Partnership participant countries. Suffering from the lack of clear strategy and ultimate goal in the European Neighbourhood Policy the European Union enhances external democratization and its governance in post soviet states without immediate Union's membership perspective. Underestimation of common neighbourhood geopolitical duality in the context of growing rivalry between European (EU and Eurasian (Custom Union/Eurasian Economic Union integration gravitation centers presents the Eastern partners of the EU with a fierce dilemma of externally forced immediate geopolitical and civilizational choice while not all of them are well prepared to such a choice. The mutual Europeanization trap here to be studied both for the EU and its Eastern partners (involving Russia is a deficiency of regulating cooperation mechanism in the situation of European and Eurasian free trades zones overlapping. Vilnius Summit 2013 results test the "European aspirations" of the New Independent States and upset the ongoing process of the European Neighbourhood Policy in the context of growing economic interdependence in Wider Europe. Besides, the Ukrainian crisis escalation during 2014 as a new seat of tension provokes unbalance of the whole European security system and creates new dividing lines in Europe from Vancouver to Vladivostok.

  14. The liberalization of the European gas market and its consequences for Russia

    Energy Technology Data Exchange (ETDEWEB)

    Finon, D.; Locatelli, C


    Russia is the world biggest natural gas producer, with output of 581 bn m{sup 3} in 2001, and is also a key supplier of the European gas market (around 30% of current European Union gas imports). Therefore gas exports rank with oil exports as an essential variable of Russian economic policy, and any institutional evolution of its gas export markets is crucial for Russia's economy as well as its gas industry. Liberalization of the European gas market will have major consequences for main suppliers, and therefore for Russia. (author)

  15. Characterization of oil obtained from grape seeds collected during berry development. (United States)

    Rubio, Manuela; Alvarez-Ortí, Manuel; Alvarruiz, Andrés; Fernández, Enrique; Pardo, Jose E


    The surpluses of the wine industry that originate from wine production in the European countries must be reduced. Green harvesting, consisting in collecting the grapes when they are still green, could contribute to the reduction of the yield of vineyards. The green grapes are not suitable for wine production, but they can be used for seed oil extraction. Grape seed oil is a linoleic acid rich oil that has been suggested as an alternative to traditional vegetable edible oils. In this work, grape samples were collected at different stages during berry development for seed oil extraction. The grapes collected at a very early stage showed a very low oil extraction yield compared with that of the samples collected at later stages. The oil from the grapes collected at an early stage had considerably higher sterols content and had a significantly different fatty acid composition compared with those of the oil extracted from grapes collected at later stages. However, the oil samples from grapes collected before veraison did not show significant differences with samples collected after veraison as regards oil extraction yield, fatty acids composition, and total sterol content and composition. Our data suggest that grapes collected from green harvesting near veraison could be suitable for seed oil extraction, with characteristics similar to those of the oil extracted from the seeds of mature grapes.

  16. The European populist challenge

    Directory of Open Access Journals (Sweden)

    Yannis Stavrakakis


    Full Text Available In today’s Europe, the word ‘populism’ usually refers to right-wing populism or the populist extreme right. Is, however, the concept of ‘populism’ the proper theoreticopolitical instrument through which such identifications should be perceived, categorized and debated? What are the implications (direct and indirect of such a naming? And what are the risks for critical analysis and for democratic politics in the European context? The hypothesis explored in this essay is that sticking to a restrictive association between ‘populism’ and the extreme right poses certain dangers that have to be seriously taken into account, especially in times of crisis. For a start, it is often premised on a rather simplistic euro-centrism that reduces the broad conceptual spectrum covered by the category ‘populism’ in its global use to a very particular European experience and then essentializes the resulting association, over-extending its scope. In addition, the category ‘populism’ is aften used to describe political forces, identities and discourses in which the role of ‘the people’ is only secondary or peripheral, to the extent that it has to coincide with strongly hierarchical and elitist visions of society. What complicates things even further is that, within the context of the European (economic and political crisis, whoever questions/ resists the austerity agenda – especially on the left – is increasingly discredited and denounced as an irresponsible populist. Indeed, it is not by coincidence that doubts are increasingly voiced both in the theoretical and in the political literature regarding the rationale behind such a strong association between populism and the extreme right. A series of points will thus be raised that may help us develop a plausible theoretico-political strategy in the new emerging conditions from a discursive perspective.*

  17. European Network Against Racism

    DEFF Research Database (Denmark)

    Nielsen, Helene Pristed

    of discussions about intersectionality, the article investigates ENAR´s attention and ability to integrate questions of e.g. gender, sexuality or age in their policy input, given the potentially rigid compartmentalisation of discrimination strands within the European Commission´s system of civil society...... consultations. The article therefore overall aims to assess ENAR´s position as potentially hemmed in between 1) the Commission vs. member organisations’ expectations for its focus and modus operandi and 2) attention to intersectional discrimination vs. potential compartmentalisation within the Commission...

  18. Cooperative strategies European perspectives

    CERN Document Server

    Killing, J Peter


    Cooperative Strategies: European Perspectives is one of three geographically targeted volumes in which the contributors present the most current research on topics such as advances in theories of cooperative strategies, the formation of cooperative alliances, the dynamics of partner relationships, and the role of information and knowledge in cooperative alliances. Blending conceptual insights with empirical analyses, the contributors highlight commonalities and differences across national, cultural, and trade zones. The chapters in this volume are anchored in a wide set of theoretical approaches, conceptual frameworks, and models, illustrating how rich the area of cooperative strategies is for scholarly inquiry.

  19. European Regional Modernism

    Directory of Open Access Journals (Sweden)

    Vincent Brian Canizaro


    Full Text Available In recent years, beginning with the publication in 2003 of Liane Lefaivre and Alexander Tzonis’ 'Critical Regionalism', followed by my 'Architectural Regionalism: Collected Writings on Place, Identity, Modernity and Tradition 'in 2007, there has been a quiet resurgence in the discourse of architectural regionalism.' 'Leuven University Press’s 'Regionalism and Modernity: Architecture in Western Europe 1914–1940 'continues in this direction, with eleven chapters devoted to variations of the regionalist tendency in European architecture focused primarily on Belgium and France, but also Great Britain, Italy, and Germany.

  20. European Union of Memories?

    DEFF Research Database (Denmark)

    Wæhrens, Anne

    After a very brief introduction to history and memory in Europe after 1989, as seen by Aleida Assmann, I will give a short introduction to the EP and to their adoption of resolutions and declarations. Then I will define some concepts central to my study before I proceed to the analysis. Finally I...... these changes have come about. Moreover, I show that there seems to be a political memory split between Left and Right and I suggest that the time might not be ripe for a shared European memory....

  1. European Union Budget Politics

    DEFF Research Database (Denmark)

    Citi, Manuele


    The marginal involvement of the European Union (EU) in redistributive policies and its limited fiscal resources have led to a notable lack of attention by EU scholars towards the EU budget and its dynamics. Yet the nature of the budgetary data and their high usability for statistical analysis make...... them an excellent tool for studying and measuring policy change in the EU. In this article, I analyse an original dataset containing yearly data for the main categories of expenditure and how they have changed over the last three decades (1979–2013). Using time-series analysis, I find that the ability...

  2. High quality bio-oil from catalytic flash pyrolysis of lignocellulosic biomass over alumina-supported sodium carbonate

    NARCIS (Netherlands)

    Ali Imran, A.; Bramer, Eduard A.; Seshan, Kulathuiyer; Brem, Gerrit


    Performance of a novel alumina-supported sodium carbonate catalyst was studied to produce a valuable bio-oil from catalytic flash pyrolysis of lignocellulosic biomass. Post treatment of biomass pyrolysis vapor was investigated in a catalyst fixed bed reactor at the downstream of the pyrolysis

  3. How campaigns enhance European issues voting during European Parliament elections

    DEFF Research Database (Denmark)

    Beach, Derek; Møller Hansen, Kasper; Larsen, Martin Vinæs


    allegiances less important and attitudes about the European project more important by informing voters of and getting them interested in European politics. In effect, we argue that the political campaign leading up to the election makes European Parliament elections less second-order. While previous studies...... have demonstrated that EU attitudes can matter for voting behavior in European Parliament elections, existing research has drawn on post-election surveys that do not enable us to capture campaign effects. Our contribution is to assess the impact of a campaign by utilizing a rolling cross sectional......Based on findings from the literature on campaign effects on the one hand, and the literature on European Parliament elections on the other, we propose a model of European Parliamentary elections in which the campaign shift the calculus of electoral support, making differences in national political...

  4. Nutritional properties of poppyseed oil relative to some other oils. (United States)

    Beare-Rogers, J L; Gray, L; Nera, E A; Levin, O L


    Male Wistar rats were fed a purified basal diet with 20% lard and corn oil (3:1), sunflower oil, poppyseed oil, low-erucic rapeseed oil from Brassica napus, cultivar Tower, or mixtures of these oils, for 1 or 26 weeks. None of the hearts exhibited lipidosis at 1 week. At 26 weeks, the level of serum triglycerides was higher in rats fed the mixture of lard and corn oil than in those fed only vegetable oil, and the incidence of cardiac necrosis and fibrosis was higher in rats fed the rapeseed oil than in the other animals. Cardiac phospholipids in rats fed the rapeseed oil contained an elevated level of omega 3 docosahexaenoic acid, particularly in phosphatidylethanolamine. Poppyseed oil exhibited properties similar to those of sunflower oil, was absorbed as well as olive oil, and appeared to be a promising oil for human consumption.

  5. Europeanness: A Path To Unity Within The European Union

    Directory of Open Access Journals (Sweden)

    Piasecki Ryszard


    Full Text Available The postwar experience has shown that the implanting of European consciousness, or Europeanness, calls for coordinated efforts among the European institutions, national states, and NGOs. Such consciousness, a key pillar of the European integration, is necessary for the EU to effectively function and motivate member states’ − also the EU’s − citizens. And yet European institutions and EU governments show little interest in promoting the formation of this European consciousness. Pro-European social movements are weak, while anti- European ones gain strength. This désintéressement of the EU countries probably results from the conviction that the goal has been reached and that there is no more need for a widespread pro-European education of their societies. However analysis of the problem, and in particular of the interaction between European and national identities, shows that this is not the case. We fear that this lack of proactive measures mobilizing EU citizens to keep on struggling for a common Europe will lead to the erosion of existing achievements of integration within the EU, and undermine European values. It may threaten the future of the EU, which is not an ordinary integration grouping but a great peaceful, civilizational, social and economic project. Our hypothesis − positively verified in this article − is that the promotion of Europeanness in the EU societies is urgently needed to maintain the unity (and even membership of the Union, and to avert trends unfavorable for all of Europe and therefore for the West as a whole.

  6. Stochastic modeling of Cryptosporidium parvum to predict transport, retention, and downstream exposure (United States)

    Drummond, J. D.; Boano, F.; Atwill, E. R.; Li, X.; Harter, T.; Packman, A. I.


    Rivers are a means of rapid and long-distance transmission of pathogenic microorganisms from upstream terrestrial sources. Thus, significant fluxes of pathogen loads from agricultural lands can occur due to transport in surface waters. Pathogens enter streams and rivers in a variety of processes, notably overland flow, shallow groundwater discharge, and direct inputs from host populations such as humans and other vertebrate species. Viruses, bacteria, and parasites can enter a stream and persist in the environment for varying amounts of time. Of particular concern is the protozoal parasite, Cryptosporidium parvum, which can remain infective for weeks to months under cool and moist conditions, with the infectious state (oocysts) largely resistant to chlorination. In order to manage water-borne diseases more effectively we need to better predict how microbes behave in freshwater systems, particularly how they are transported downstream in rivers and in the process interact with the streambed and other solid surfaces. Microbes continuously immobilize and resuspend during downstream transport due to a variety of processes, such as gravitational settling, attachment to in-stream structures such as submerged macrophytes, and hyporheic exchange and filtration within underlying sediments. These various interactions result in a wide range of microbial residence times in the streambed and therefore influence the persistence of pathogenic microbes in the stream environment. We developed a stochastic mobile-immobile model to describe these microbial transport and retention processes in streams and rivers that also accounts for microbial inactivation. We used the model to assess the transport, retention, and inactivation of C. parvum within stream environments, specifically under representative flow conditions of California streams where C. parvum exposure can be at higher risk due to agricultural nonpoint sources. The results demonstrate that the combination of stream reach

  7. On the electron temperature downstream of the solar wind termination shock

    Directory of Open Access Journals (Sweden)

    I. V. Chashei


    Full Text Available In this paper we study the temperatures of electrons convected with the solar wind to large solar distances and finally transported over the solar wind termination shock. Nearly nothing, unless at high energies in the cosmic ray regime, is known about the thermodynamical behaviour of these distant electrons from in~situ plasma observations. Hence it is tacitly assumed these electrons, due to their adiabatic behaviour and vanishing heat conduction or energization processes, have rapidly cooled off to very low temperatures once they eventually arrive at the solar wind termination shock (at about 100 AU. In this paper we show that such electrons, however, at their passage over the termination shock due to the shock–electric field action undergo an over-adiabatic heating and therefore appear on the downstream side as a substantially heated plasma species. Looking quantitatively into this heating process we find that solar wind electrons achieve temperatures of the order of 2–4 × 106 K downstream of the termination shock, depending on the upstream solar wind bulk velocity and the shock compression ratio. Hence these electrons therewith play an important dynamical role in structuring this shock and determining the downstream plasma flow properties. Furthermore, they present an additional ionization source for incoming neutral interstellar hydrogen and excite X-ray emission. They also behave similar to cosmic ray electrons and extend to some limited region upstream of the shock of the order of 0.1 AU by spatial diffusion and thereby also modify the upstream solar wind properties.

  8. 27 CFR 21.98 - Bone oil (Dipple's oil). (United States)


    ... 27 Alcohol, Tobacco Products and Firearms 1 2010-04-01 2010-04-01 false Bone oil (Dipple's oil....98 Bone oil (Dipple's oil). (a) Color. The color shall be a deep brown. (b) Distillation range. When... below 90 °C. (c) Pyrrol reaction. Prepare a 1.0 percent solution of bone oil in 95 percent alcohol...

  9. Has dyke development in the Vietnamese Mekong Delta shifted flood hazard downstream?

    Directory of Open Access Journals (Sweden)

    N. V. K. Triet


    Full Text Available In the Vietnamese part of the Mekong Delta (VMD the areas with three rice crops per year have been expanded rapidly during the last 15 years. Paddy-rice cultivation during the flood season has been made possible by implementing high-dyke flood defenses and flood control structures. However, there are widespread claims that the high-dyke system has increased water levels in downstream areas. Our study aims at resolving this issue by attributing observed changes in flood characteristics to high-dyke construction and other possible causes. Maximum water levels and duration above the flood alarm level are analysed for gradual trends and step changes at different discharge gauges. Strong and robust increasing trends of peak water levels and duration downstream of the high-dyke areas are found with a step change in 2000/2001, i.e. immediately after the disastrous flood which initiated the high-dyke development. These changes are in contrast to the negative trends detected at stations upstream of the high-dyke areas. This spatially different behaviour of changes in flood characteristics seems to support the public claims. To separate the impact of the high-dyke development from the impact of the other drivers – i.e. changes in the flood hydrograph entering the Mekong Delta, and changes in the tidal dynamics – hydraulic model simulations of the two recent large flood events in 2000 and 2011 are performed. The hydraulic model is run for a set of scenarios whereas the different drivers are interchanged. The simulations reveal that for the central VMD an increase of 9–13 cm in flood peak and 15 days in duration can be attributed to high-dyke development. However, for this area the tidal dynamics have an even larger effect in the range of 19–32 cm. However, the relative contributions of the three drivers of change vary in space across the delta. In summary, our study confirms the claims that the high-dyke development has raised the flood

  10. Has dyke development in the Vietnamese Mekong Delta shifted flood hazard downstream? (United States)

    Van Khanh Triet, Nguyen; Viet Dung, Nguyen; Fujii, Hideto; Kummu, Matti; Merz, Bruno; Apel, Heiko


    In the Vietnamese part of the Mekong Delta (VMD) the areas with three rice crops per year have been expanded rapidly during the last 15 years. Paddy-rice cultivation during the flood season has been made possible by implementing high-dyke flood defenses and flood control structures. However, there are widespread claims that the high-dyke system has increased water levels in downstream areas. Our study aims at resolving this issue by attributing observed changes in flood characteristics to high-dyke construction and other possible causes. Maximum water levels and duration above the flood alarm level are analysed for gradual trends and step changes at different discharge gauges. Strong and robust increasing trends of peak water levels and duration downstream of the high-dyke areas are found with a step change in 2000/2001, i.e. immediately after the disastrous flood which initiated the high-dyke development. These changes are in contrast to the negative trends detected at stations upstream of the high-dyke areas. This spatially different behaviour of changes in flood characteristics seems to support the public claims. To separate the impact of the high-dyke development from the impact of the other drivers - i.e. changes in the flood hydrograph entering the Mekong Delta, and changes in the tidal dynamics - hydraulic model simulations of the two recent large flood events in 2000 and 2011 are performed. The hydraulic model is run for a set of scenarios whereas the different drivers are interchanged. The simulations reveal that for the central VMD an increase of 9-13 cm in flood peak and 15 days in duration can be attributed to high-dyke development. However, for this area the tidal dynamics have an even larger effect in the range of 19-32 cm. However, the relative contributions of the three drivers of change vary in space across the delta. In summary, our study confirms the claims that the high-dyke development has raised the flood hazard downstream. However, it is not

  11. To what extent can green infrastructure mitigate downstream flooding in a peri-urban catchment? (United States)

    Schubert, J. E.; Burns, M.; Sanders, B. F.; Flethcher, T.


    In this research, we couple an urban hydrologic model (MUSIC, eWater, AUS) with a fine resolution 2D hydrodynamic model (BreZo, UC Irvine, USA) to test to what extent retrofitting an urban watershed with stormwater control measures (SCMs) can propagate flood management benefits downstream. Our study site is the peri-urban Little Stringybark Creek (LSC) catchment in eastern Melbourne, AUS, with an area of 4.5 km2 and connected impervious area of 9%. Urban development is mainly limited to the upper 2 km2of the catchment. Since 2009 the LSC catchment has been the subject of a large-scale experiment aiming to restore morenatural flow by implementing over 300 SCMs, such as rain tanks and infiltration trenches, resulting in runoff from 50% of connected impervious areas now being intercepted by some form of SCM. For our study we calibrated the hydrologic and hydraulic models based on current catchment conditions, then we developed models representing alternative SCM scenarios including a complete lack of SCMs versus a full implementation of SCMs. Flow in the hydrologic/hydraulic models is forced using a range of synthetic rainfall events with annual exceedance probabilities (AEPs) between 63-1% and durations between 10 min to 24 hr. Metrics of SCM efficacy in changing flood regime include flood depths and extents, flow intensity (m2/s), flood duration, and critical storm duration leading to maximum flood conditions. Results indicate that across the range of AEPs tested and for storm durations equal or less than 3 hours, current SCM conditions reduce downstream flooded area on average by 29%, while a full implementation of SCMs would reduce downstream flooded area on average by 91%. A full implementation of SCMs could also lower maximum flow intensities by 83% on average, reducing damage potential to structures in the flow path and increasing the ability for vehicles to evacuate flooded streets. We also found that for storm durations longer than 3 hours, the SCMs capacity

  12. Advances in downstream processing of biologics - Spectroscopy: An emerging process analytical technology. (United States)

    Rüdt, Matthias; Briskot, Till; Hubbuch, Jürgen


    Process analytical technologies (PAT) for the manufacturing of biologics have drawn increased interest in the last decade. Besides being encouraged by the Food and Drug Administration's (FDA's) PAT initiative, PAT promises to improve process understanding, reduce overall production costs and help to implement continuous manufacturing. This article focuses on spectroscopic tools for PAT in downstream processing (DSP). Recent advances and future perspectives will be reviewed. In order to exploit the full potential of gathered data, chemometric tools are widely used for the evaluation of complex spectroscopic information. Thus, an introduction into the field will be given. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

  13. Modelling landslide-generated tsunami: from landslide propagation to downstream flood in dam context (United States)

    Franz, Martin; Podladchikov, Yury; Humair, Florian; Matasci, Battista; Jaboyedoff, Michel


    Alpine regions have a high density of dammed lakes, either natural or anthropogenic. Those are frequently surrounded by steep slopes and thus, are potentially affected by mass wasting processes. The penetration of landsliding material in the water body may lead to impulse waves that could overtop the dam and, in the worst case scenario, breach or break the latter. The possible resulting outburst flood is a serious threat for populated places, commonly concentrated downstream in the valleys. In order to assess the risk resulting from the succession of all phenomenon, a numerical model able to handle all of them is required. Although specific models of flooding simulation or wave propagation are efficient, there is currently no fully achieved model capable to integrate all the above-mentioned processes at the same time. In order to address this, we propose a new model capable to handle these difficult combinations and which is suitable for risk assessment in dam contexts. Our model is based on both the shallow water equations and viscous flow equations. The first ones are stabilised by the Lax-Friedrichs scheme and compute the wave propagation and the downstream flow, i.e. the wet state. The viscous flow equations are used for the dry state and to propagate the landslide body. The transition from one state to the other is ruled by a threshold based on the Reynolds number. First, in order to test the capacity of our model to endure critical situations, we conducted numerical sandbox tests such as Riemann problems, dam break, and landslide tsunami-related ones in 2 dimensions. In a second time, the model is applied on a real case study: the Oeschinen Lake (Switzerland). This naturally dammed lake is specifically selected since it is potentially affected by all above-mentioned phenomenon, including landsliding, wave generation, wave propagation in the water body and on the shore as well as the downstream flooding. Results show that the municipality of Kandersteg

  14. Induction of postmitotic neuroretina cell proliferation by distinct Ras downstream signaling pathways. (United States)

    Peyssonnaux, C; Provot, S; Felder-Schmittbuhl, M P; Calothy, G; Eychène, A


    Ras-induced cell transformation is mediated through distinct downstream signaling pathways, including Raf, Ral-GEFs-, and phosphatidylinositol 3-kinase (PI 3-kinase)-dependent pathways. In some cell types, strong activation of the Ras-Raf-MEK-extracellular signal-regulated kinase (ERK) cascade leads to cell cycle arrest rather than cell division. We previously reported that constitutive activation of this pathway induces sustained proliferation of primary cultures of postmitotic chicken neuroretina (NR) cells. We used this model system to investigate the respective contributions of Ras downstream signaling pathways in Ras-induced cell proliferation. Three RasV12 mutants (S35, G37, and C40) which differ by their ability to bind to Ras effectors (Raf, Ral-GEFs, and the p110 subunit of PI 3-kinase, respectively) were able to induce sustained NR cell proliferation, although none of these mutants was reported to transform NIH 3T3 cells. Furthermore, they all repressed the promoter of QR1, a neuroretina growth arrest-specific gene. Overexpression of B-Raf or activated versions of Ras effectors Rlf-CAAX and p110-CAAX also induced NR cell division. The mitogenic effect of the RasC40-PI 3-kinase pathway appears to involve Rac and RhoA GTPases but not the antiapoptotic Akt (protein kinase B) signaling. Division induced by RasG37-Rlf appears to be independent of Ral GTPase activation and presumably requires an unidentified mechanism. Activation of either Ras downstream pathway resulted in ERK activation, and coexpression of a dominant negative MEK mutant or mKsr-1 kinase domain strongly inhibited proliferation induced by the three Ras mutants or by their effectors. Similar effects were observed with dominant negative mutants of Rac and Rho. Thus, both the Raf-MEK-ERK and Rac-Rho pathways are absolutely required for Ras-induced NR cell division. Activation of these two pathways by the three distinct Ras downstream effectors possibly relies on an autocrine or paracrine loop

  15. Export of Organic Matter and Microbes from the Greenland Ice Sheet: Sources, Composition, and Downstream Implications (United States)

    Kohler, T. J.; Zarsky, J. D.; Cameron, K.; Lamarche-Gagnon, G.; Hawkings, J.; Telling, J.; Tedstone, A.; Wadham, J.; Jacobsen, C. S.; Yde, J. C.; Stibal, M.


    Meltwater runoff from the Greenland Ice Sheet (GrIS) has increased by more than 50% in the last 50 years. While considerable uncertainty revolves around the impact this change may have on downstream ecosystems, previous research has suggested that solute and microbial exports from the GrIS are likely to increase with higher freshwater fluxes. We monitored the Watson River, a glacially fed river in West Greenland, over the 2012 and 2015 summers to evaluate the influence increased fluxes may exert on local microbial communities and downstream biogeochemical cycles. Our objectives were to approximate the number of cells exported, characterize cell assemblages, and determine their origin. In 2012, paired microbiological samples were taken sporadically at the Leverett Glacier meltwater portal (at the head of the Watson River) and the Watson River fjord outlet 30 km downstream, to quantify microbial cells and characterize assemblage structure. We found cell concentrations and microbial assemblages to be very similar between locations, despite their distance apart. This suggests that GrIS outlet rivers are "neutral pipes" connecting microbes between glacial and estuarine habitats. We further identified subtle shifts in assemblage structure over the course of the summer melt season (May to August), and hypothesized that this reflects an expanding subglacial drainage network, with waters draining parts of the GrIS bed progressively further inland as the melt season progressed. Meltwaters from the Leverett Glacier portal were again monitored during the 2015 summer to identify the source of exported microbes by sampling during or near outburst events, which flush long-term stored waters from the ice-sheet bed. Using 14C dating, we found that exported suspended sediment-bound carbon becomes progressively older from June to August. This suggests that different reservoirs are tapped as the melt season progresses, which we interpret as originating from a greater distance into the

  16. Assessing European capacity for geological storage of carbon dioxide-the EU GeoCapacity project

    NARCIS (Netherlands)

    Vangkilde-Pedersen, T.; Anthonsen, K.L.; Smith, N.; Kirk, K.; Neele, F.; Meer, B. van der; Le Gallo, Y. le; Bossie-Codreanu, D.; Wojcicki, A.; Nindre, Y.-M. le; Hendriks, C.; Dalhoff, F.; Peter Christensen, N.


    The focus of the GeoCapacity project is GIS mapping of CO2 point sources, infrastructure and geological storage in Europe. The main objective is to assess the European capacity for geological storage of CO2 in deep saline aquifers, oil and gas structures and coal beds. Other priorities are further

  17. Microsatellite analysis of Rosa damascena Mill. accessions reveals genetic similarity between genotypes used for rose oil production and old Damask rose varieties. (United States)

    Rusanov, K; Kovacheva, N; Vosman, B; Zhang, L; Rajapakse, S; Atanassov, A; Atanassov, I


    Damask roses are grown in several European and Asiatic countries for rose oil production. Twenty-six oil-bearing Rosa damascena Mill. accessions and 13 garden Damask roses were assayed by molecular markers. Microsatellite genotyping demonstrated that R. damascena Mill. accessions from Bulgaria, Iran, and India and old European Damask rose varieties possess identical microsatellite profiles, suggesting a common origin. At the same time, the data indicated that modern industrial oil rose cultivation is based on a very narrow genepool and that oil rose collections contain many genetically identical accessions. The study of long-term vegetative propagation of the Damask roses also reveals high somatic stability for the microsatellite loci analyzed.

  18. Halogens in oil and gas production-associated wastewater. (United States)

    Harkness, J.; Warner, N. R.; Dwyer, G. S.; Mitch, W.; Vengosh, A.


    Elevated chloride and bromide in oil and gas wastewaters that are released to the environment are one of the major environmental risks in areas impacted by shale gas development [Olmstead et al.,2013]. In addition to direct contamination of streams, the potential for formation of highly toxic disinfection by-products (DBPs) in drinking water in utilities located downstream from disposal sites poses a serious risk to human health. Here we report on the occurrence of iodide in oil and gas wastewater. We conducted systematic measurements of chloride, bromide, and iodide in (1) produced waters from conventional oil and gas wells from the Appalachian Basin; (2) hydraulic fracturing flowback fluids from unconventional Marcellus and Fayetteville shale gas, (3) effluents from a shale gas spill site in West Virginia; (4) effluents of oil and gas wastewater disposed to surface water from three brine treatment facilities in western Pennsylvania; and (5) surface waters downstream from the brine treatment facilities. Iodide concentration was measured by isotope dilution-inductively coupled plasma-mass spectrometry, which allowed for a more accurate measurement of iodide in a salt-rich matrix. Iodide in both conventional and unconventional oil and gas produced and flowback waters varied from 1 mg/L to 55 mg/L, with no systematic enrichment in hydraulic fracturing fluids. The similarity in iodide content between the unconventional Marcellus flowback waters and the conventional Appalachian produced waters clearly indicate that the hydraulic fracturing process does not induce additional iodide and the iodide content is related to natural variations in the host formations. Our data show that effluents from the brine treatment facilities have elevated iodide (mean = 20.9±1 mg/L) compared to local surface waters (0.03± 0.1 mg/L). These results indicate that iodide, in addition to chloride and bromide in wastewater from oil and gas production, poses an additional risk to downstream

  19. Chemometric techniques in oil classification from oil spill fingerprinting. (United States)

    Ismail, Azimah; Toriman, Mohd Ekhwan; Juahir, Hafizan; Kassim, Azlina Md; Zain, Sharifuddin Md; Ahmad, Wan Kamaruzaman Wan; Wong, Kok Fah; Retnam, Ananthy; Zali, Munirah Abdul; Mokhtar, Mazlin; Yusri, Mohd Ayub


    Extended use of GC-FID and GC-MS in oil spill fingerprinting and matching is significantly important for oil classification from the oil spill sources collected from various areas of Peninsular Malaysia and Sabah (East Malaysia). Oil spill fingerprinting from GC-FID and GC-MS coupled with chemometric techniques (discriminant analysis and principal component analysis) is used as a diagnostic tool to classify the types of oil polluting the water. Clustering and discrimination of oil spill compounds in the water from the actual site of oil spill events are divided into four groups viz. diesel, Heavy Fuel Oil (HFO), Mixture Oil containing Light Fuel Oil (MOLFO) and Waste Oil (WO) according to the similarity of their intrinsic chemical properties. Principal component analysis (PCA) demonstrates that diesel, HFO, MOLFO and WO are types of oil or oil products from complex oil mixtures with a total variance of 85.34% and are identified with various anthropogenic activities related to either intentional releasing of oil or accidental discharge of oil into the environment. Our results show that the use of chemometric techniques is significant in providing independent validation for classifying the types of spilled oil in the investigation of oil spill pollution in Malaysia. This, in consequence would result in cost and time saving in identification of the oil spill sources. Copyright © 2016. Published by Elsevier Ltd.

  20. Rainfall-runoff modelling of the Okavango River catchment to assess impacts of land use change on runoff and downstream ecosystems (United States)

    Milzow, Christian; Bauer-Gottwein, Peter


    The competition between human water use and ecosystem water use is one of the major challenges for water resources management at the global scale. We analyse the situation for the Okavango River basin of southern Africa. The Okavango River is representative for many large rivers throughout the developing world in that it is ungauged and poorly studied. The Okavango basin - spanning over Angola, Namibia and Botswana - represents a multi-objective problem in an international setting. Economic benefits of agricultural development and conservation of ecosystem services call for opposed actions. A semi-distributed rainfall-runoff model of the Okavango catchment is set up using the Soil and Water Assessment Tool (SWAT). The model is sufficiently physically based to simulate the impact on runoff of extent of agricultural use, crop types and management practices. Precipitation and temperature inputs are taken from datasets covering large parts of the globe. The methodology can thus easily be applied for other ungauged catchments. For temperature we use the ERA-Interim reanalysis product of the European Centre for Medium-Range Weather Forecasts and for precipitation the Famine Early Warning Systems Network data (FEWS-Net). Tropical Rainfall Measurement Mission (TRMM) data resulted in poor model performance compared to the FEWS-Net data. Presently, the upstream catchment in Angola is largely pristine and agriculture is basically restricted to dry land subsistence farming. But economic growth in Angola is likely to result in agricultural development and consequent impacts on catchment runoff. Land use scenarios that are simulated include large scale irrigated agriculture with water extractions from the river and the shallow aquifer. Climate change impacts are also studied and compared to land use change impacts. The downstream part of the basin consists of the large Okavango Wetlands, which are a biodiversity hotspot of global importance and, through tourism, an important

  1. Resolution of thermal striping issue downstream of a horizontal pipe elbow in stratified pipe flow. [LMFBR

    Energy Technology Data Exchange (ETDEWEB)

    Kuzay, T.M.; Kasza, K.E.


    A thermally stratified pipe flow produced by a thermal transient when passing through a horizontal elbow as a result of secondary flow gives rise to large thermal fluctuations on the inner curvature wall of the downstream piping. These fluctuations were measured in a specially instrumented horizontal pipe and elbow system on a test set-up using water in the Mixing Components Technology Facility (MCTF) at Argonne National Laboratory (ANL). This study is part of a larger program which is studying the influence of thermal buoyancy on general reactor component performance. This paper discusses the influence of pipe flow generated thermal oscillations on the thermal stresses induced in the pipe walls. The instrumentation was concentrated around the exit plane of the 90/sup 0/ sweep elbow, since prior tests had indicated that the largest thermal fluctuations would occur within about one hydraulic diameter downstream of the elbow exit. The thermocouples were located along the inner curvature of the piping and measured the near surface fluid temperature. The test matrix involved thermal downramps under turbulent flow conditions.

  2. Novel Strategies for Upstream and Downstream Processing of Tannin Acyl Hydrolase (United States)

    Rodríguez-Durán, Luis V.; Valdivia-Urdiales, Blanca; Contreras-Esquivel, Juan C.; Rodríguez-Herrera, Raúl; Aguilar, Cristóbal N.


    Tannin acyl hydrolase also referred as tannase is an enzyme with important applications in several science and technology fields. Due to its hydrolytic and synthetic properties, tannase could be used to reduce the negative effects of tannins in beverages, food, feed, and tannery effluents, for the production of gallic acid from tannin-rich materials, the elucidation of tannin structure, and the synthesis of gallic acid esters in nonaqueous media. However, industrial applications of tannase are still very limited due to its high production cost. Thus, there is a growing interest in the production, recovery, and purification of this enzyme. Recently, there have been published a number of papers on the improvement of upstream and downstream processing of the enzyme. These papers dealt with the search for new tannase producing microorganisms, the application of novel fermentation systems, optimization of culture conditions, the production of the enzyme by recombinant microorganism, and the design of efficient protocols for tannase recovery and purification. The present work reviews the state of the art of basic and biotechnological aspects of tannin acyl hydrolase, focusing on the recent advances in the upstream and downstream processing of the enzyme. PMID:21941633

  3. Delineation of downstream signalling components during acrosome reaction mediated by heat solubilized human zona pellucida

    Directory of Open Access Journals (Sweden)

    Talwar Pankaj


    Full Text Available Abstract Background Human egg is enveloped by a glycoproteinaceous matrix, zona pellucida (ZP, responsible for binding of the human spermatozoa to the egg and induction of acrosomal exocytosis in the spermatozoon bound to ZP. In the present manuscript, attempts have been made to delineate the downstream signalling components employed by human ZP to induce acrosome reaction. Methods Heat-solubilized human ZP (SIZP was used to study the induction of acrosome reaction in capacitated human spermatozoa using tetramethylrhodamine isothiocyanate conjugated Pisum sativum agglutinin (TRITC-PSA in absence or presence of various pharmacological inhibitors. In addition, intracellular calcium ([Ca2+]i levels in sperm using Fluo-3 acetoxymethyl ester as fluorescent probe were also estimated in response to SIZP. Results SIZP induces acrosomal exocytosis in capacitated human sperm in a dose dependent manner accompanied by an increase in [Ca2+]i. Human SIZP mediated induction of acrosome reaction depends on extracellular Ca2+ and involves activation of Gi protein-coupled receptor, tyrosine kinase, protein kinases A & C and phosphoinositide 3 (PI3- kinase. In addition, T-type voltage operated calcium channels and GABA-A receptor associated chloride (Cl- channels play an important role in SIZP mediated induction of acrosome reaction. Conclusions Results described in the present study provide a comprehensive account of the various downstream signalling components associated with human ZP mediated acrosome reaction.

  4. Single pass tangential flow filtration to debottleneck downstream processing for therapeutic antibody production. (United States)

    Dizon-Maspat, Jemelle; Bourret, Justin; D'Agostini, Anna; Li, Feng


    As the therapeutic monoclonal antibody (mAb) market continues to grow, optimizing production processes is becoming more critical in improving efficiencies and reducing cost-of-goods in large-scale production. With the recent trends of increasing cell culture titers from upstream process improvements, downstream capacity has become the bottleneck in many existing manufacturing facilities. Single Pass Tangential Flow Filtration (SPTFF) is an emerging technology, which is potentially useful in debottlenecking downstream capacity, especially when the pool tank size is a limiting factor. It can be integrated as part of an existing purification process, after a column chromatography step or a filtration step, without introducing a new unit operation. In this study, SPTFF technology was systematically evaluated for reducing process intermediate volumes from 2× to 10× with multiple mAbs and the impact of SPTFF on product quality, and process yield was analyzed. Finally, the potential fit into the typical 3-column industry platform antibody purification process and its implementation in a commercial scale manufacturing facility were also evaluated. Our data indicate that using SPTFF to concentrate protein pools is a simple, flexible, and robust operation, which can be implemented at various scales to improve antibody purification process capacity. Copyright © 2011 Wiley Periodicals, Inc.

  5. Longitudinal distribution of Chironomidae (Diptera) downstream from a dam in a neotropical river. (United States)

    Pinha, G D; Aviz, D; Lopes Filho, D R; Petsch, D K; Marchese, M R; Takeda, A M


    The damming of a river causes dangerous consequences on structure of the environment downstream of the dam, modifying the sediment composition, which impose major adjustments in longitudinal distribution of benthic community. The construction of Engenheiro Sérgio Motta Dam in the Upper Paraná River has caused impacts on the aquatic communities, which are not yet fully known. This work aimed to provide more information about the effects of this impoundment on the structure of Chironomidae larvae assemblage. The analysis of data of physical and chemical variables in relation to biological data of 8 longitudinal sections in the Upper Paraná River showed that composition of Chironomidae larvae of stations near Engenheiro Sérgio Motta Dam differed of the other stations (farther of the Dam). The predominance of coarse sediments at stations upstream and finer sediments further downstream affected the choice of habitat by different morphotypes of Chironomidae and it caused a change in the structure of this assemblage in the longitudinal stretch.

  6. Evaluating lignocellulosic biomass, its derivatives, and downstream products with Raman spectroscopy

    Directory of Open Access Journals (Sweden)

    Jason S. Lupoi


    Full Text Available The creation of fuels, chemicals, and materials from plants can aid in replacing products fabricated from non-renewable energy sources. Before using biomass in downstream applications, it must be characterized to assess chemical traits, such as cellulose, lignin, or lignin monomer content, or the sugars released following an acid or enzymatic hydrolysis. The measurement of these traits allows researchers to gauge the recalcitrance of the plants, and develop efficient deconstruction strategies to maximize yields. Standard methods for assessing biomass phenotypes often have experimental protocols that limit their use for screening sizeable numbers of plant species. Raman spectroscopy, a non-destructive, non-invasive vibrational spectroscopy technique, is capable of providing qualitative, structural information and quantitative measurements. Applications of Raman spectroscopy have aided in alleviating the constraints of standard methods by coupling spectral data with multivariate analysis to construct models capable of predicting analytes. Hydrolysis and fermentation products, such as glucose and ethanol, can be quantified off-, at-, or on-line. Raman imaging has enabled researchers to develop a visual understanding of reactions, such as different pretreatment strategies, in real time, while also providing integral chemical information. This review provides an overview of what Raman spectroscopy is, and how it has been applied to the analysis of whole lignocellulosic biomass, its derivatives, and downstream process monitoring.

  7. A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib. (United States)

    Sun, Tianliang; Yang, Lida; Kaur, Harmandeep; Pestel, Jenny; Looso, Mario; Nolte, Hendrik; Krasel, Cornelius; Heil, Daniel; Krishnan, Ramesh K; Santoni, Marie-Josée; Borg, Jean-Paul; Bünemann, Moritz; Offermanns, Stefan; Swiercz, Jakub M; Worzfeld, Thomas


    Semaphorins comprise a large family of ligands that regulate key cellular functions through their receptors, plexins. In this study, we show that the transmembrane semaphorin 4A (Sema4A) can also function as a receptor, rather than a ligand, and transduce signals triggered by the binding of Plexin-B1 through reverse signaling. Functionally, reverse Sema4A signaling regulates the migration of various cancer cells as well as dendritic cells. By combining mass spectrometry analysis with small interfering RNA screening, we identify the polarity protein Scrib as a downstream effector of Sema4A. We further show that binding of Plexin-B1 to Sema4A promotes the interaction of Sema4A with Scrib, thereby removing Scrib from its complex with the Rac/Cdc42 exchange factor βPIX and decreasing the activity of the small guanosine triphosphatase Rac1 and Cdc42. Our data unravel a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A, which controls cell migration. © 2017 Sun et al.

  8. Rhizosecretion improves the production of Cyanovirin-N in Nicotiana tabacum through simplified downstream processing. (United States)

    Madeira, Luisa M; Szeto, Tim H; Ma, Julian K-C; Drake, Pascal M W


    Rhizosecretion has many advantages for the production of recombinant pharmaceuticals, notably facile downstream processing from hydroponic medium. The aim of this study was to increase yields of the HIV microbicide candidate, Cyanovirin-N (CV-N), obtained using this production platform and to develop a simplified methodology for its downstream processing from hydroponic medium. Placing hydroponic cultures on an orbital shaker more than doubled the concentration of CV-N in the hydroponic medium compared to plants which remained stationary, reaching a maximum of approximately 20μg/ml in one week, which is more than 3 times higher than previously reported yields. The protein composition of the hydroponic medium, the rhizosecretome, was characterised in plants cultured with or without the plant growth regulator alpha-napthaleneacetic acid by LC-ESI-MS/MS, and CV-N was the most abundant protein. The issue of large volumes in the rhizosecretion system was addressed by using ion exchange chromatography to concentrate CV-N and partially remove impurities. The semi-purified CV-N was demonstrated to bind to HIV gp120 in an ELISA and to neutralise HIVBa-L with an IC50 of 6nM in a cell-based assay. Rhizosecretion is therefore a practicable and inexpensive method for the production of functional CV-N. Copyright © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. Novel Strategies for Upstream and Downstream Processing of Tannin Acyl Hydrolase

    Directory of Open Access Journals (Sweden)

    Luis V. Rodríguez-Durán


    Full Text Available Tannin acyl hydrolase also referred as tannase is an enzyme with important applications in several science and technology fields. Due to its hydrolytic and synthetic properties, tannase could be used to reduce the negative effects of tannins in beverages, food, feed, and tannery effluents, for the production of gallic acid from tannin-rich materials, the elucidation of tannin structure, and the synthesis of gallic acid esters in nonaqueous media. However, industrial applications of tannase are still very limited due to its high production cost. Thus, there is a growing interest in the production, recovery, and purification of this enzyme. Recently, there have been published a number of papers on the improvement of upstream and downstream processing of the enzyme. These papers dealt with the search for new tannase producing microorganisms, the application of novel fermentation systems, optimization of culture conditions, the production of the enzyme by recombinant microorganism, and the design of efficient protocols for tannase recovery and purification. The present work reviews the state of the art of basic and biotechnological aspects of tannin acyl hydrolase, focusing on the recent advances in the upstream and downstream processing of the enzyme.

  10. Heavy metals in sediments of Ganga River: up- and downstream urban influences (United States)

    Pandey, Jitendra; Singh, Rachna


    Bottom sediment in a river often acts as a sink and indicator of changes in water column and magnitude of anthropogenic influences through air and watersheds. Heavy metal concentration in sediments of Ganga River was studied along a 37-km stretch to assess whether there is a significant difference between sites situated upstream and downstream of Varanasi urban core. Metal concentration increased consistently along the study gradient, indicating the influence of urban sources. Concentration in the river sediment was found highest for Fe followed by Mn, Zn, Cr, Cu, Ni, Pb, and Cd. Mann-Kendall trend analysis showed marked seasonality in the concentration with values being highest in summer and lowest in rainy season. Enrichment factor revealed severe enrichment of Cd and Pb at downstream sites, and principal component analysis segregated sites into four distinct groups indicating source relationships. Concentrations of Cd, Pb, Ni, Cu, and Cr did exceed WHO standards. The study has relevance designing control measures and action plans for reducing sediment contamination in anthropogenic impacted rivers.

  11. Effects of stream-adjacent logging in fishless headwaters on downstream coastal cutthroat trout (United States)

    Bateman, Douglas S.; Sloat, Matthew R.; Gresswell, Robert E.; Berger, Aaron M.; Hockman-Wert, David; Leer, David W.; Skaugset, Arne E.


    To investigate effects of headwater logging on downstream coastal cutthroat trout (Oncorhynchus clarkii clarkii) populations, we monitored stream habitat and biotic indicators including biomass, abundance, growth, movement, and survival over 8 years using a paired-watershed approach. Reference and logged catchments were located on private industrial forestland on ∼60-year harvest rotation. Five clearcuts (14% of the logged catchment area) were adjacent to fishless portions of the headwater streams, and contemporary regulations did not require riparian forest buffers in the treatment catchment. Logging did not have significant negative effects on downstream coastal cutthroat trout populations for the duration of the sample period. Indeed, the only statistically significant response of fish populations following logging in fishless headwaters was an increase in late-summer biomass (g·m−2) of age-1+ coastal cutthroat trout in tributaries. Ultimately, the ability to make broad generalizations concerning effects of timber harvest is difficult because response to disturbance (anthropogenically influenced or not) in aquatic systems is complex and context-dependent, but our findings provide one example of environmentally compatible commercial logging in a regenerated forest setting.

  12. Highly resolved numerical simulation of combustion downstream of a rocket engine igniter (United States)

    Buttay, R.; Gomet, L.; Lehnasch, G.; Mura, A.


    We study ignition processes in the turbulent reactive flow established downstream of highly under-expanded coflowing jets. The corresponding configuration is typical of a rocket engine igniter, and to the best knowledge of the authors, this study is the first that documents highly resolved numerical simulations of such a reactive flowfield. Considering the discharge of axisymmetric coaxial under-expanded jets, various morphologies are expected, depending on the value of the nozzle pressure ratio, a key parameter used to classify them. The present computations are conducted with a value of this ratio set to fifteen. The simulations are performed with the massively parallel CREAMS solver on a grid featuring approximately 440,000,000 computational nodes. In the main zone of interest, the level of spatial resolution is D/74, with D the central inlet stream diameter. The computational results reveal the complex topology of the compressible flowfield. The obtained results also bring new and useful insights into the development of ignition processes. In particular, ignition is found to take place rather far downstream of the shock barrel, a conclusion that contrasts with early computational studies conducted within the unsteady RANS computational framework. Consideration of detailed chemistry confirms the essential role of hydroperoxyl radicals, while the analysis of the Takeno index reveals the predominance of a non-premixed combustion mode.

  13. Long-term hypo-osmoregulatory capacity in downstream migrating Atlantic salmon Salmo salar L. smolts. (United States)

    Urke, H A; Arnekleiv, J V; Nilsen, T O; Nilssen, K J; Rønning, L; Ulvund, J B; Kristensen, T


    The duration of hypo-osmoregulatory capacity in downstream migrating Atlantic salmon Salmo salar L smolts previously stocked as startfed young-of-the year (YOY) parr was tested in the River Dalåa from mid-May to late-June 1999. Hypo-osmoregulatory capacity, measured as plasma osmolality and chloride, was assessed after seawater (SW) challenge tests (168 h, salinity = 35). All S. salar exhibited sufficient hypo-osmoregulatory capacity at the initiation of downstream migration in mid-May. Migrating S. salar smolts caught in mid-May and retained in fresh water displayed no signs of de-smoltification as they maintained hypo-osmoregulatory capacity through June. This indicates a physiological smolt window that lasts a minimum of 6 weeks (330 degree days; D°) for hatchery-produced S. salar smolts stocked as YOY parr. Based on the observed river migration speeds, it can be assumed that the S. salar smolts entered SW 2-4 weeks after initiation of migration in the upper parts of the River Dalåa. Hence, based on smolt migration and SW tolerance, it is suggested that stocking of YOY parr is a viable enhancement strategy in the River Dalåa. © 2014 The Fisheries Society of the British Isles.

  14. Flow structure in the downstream of a square cylinder with different angles of incidence

    Directory of Open Access Journals (Sweden)

    N Jamshidi


    Full Text Available This paper presents comparisons between flow fields for turbulent flow over square cylinder with two different angles of incidence in free stream at Reynolds number of Re = 3400. The present numerical results were obtained using a two-dimensional finite-volume code which solves governing equations. The pressure field was obtained with well known SIMPLE algorithm. The central difference scheme was employed for the discretization of convection and diffusion terms. The ν2 f and standard k - ε model were used for simulation of turbulent flow. Time averaged velocity, root mean square velocities and streamlines in the downstream of square cylinders are presented. A number of quantities such as Strouhal number, drag coefficient and the length of the wake are calculated for the case of angle of incidence α = 0°, 45° with two turbulent models. Strouhal number and the length of the wake are larger for the case of α = 45° because of the sharp corners in it which results in more diffusion of turbulence in the downstream of the cylinder. On the other hand, with comparison of results obtained by ν2 f and standard k - ε models with experiment, it is obvious that ν2 f leads to much more accurate results.

  15. Human muscle fibre type-specific regulation of AMPK and downstream targets by exercise

    DEFF Research Database (Denmark)

    Kristensen, Dorte Enggaard; Albers, Peter Hjorth; Prats, Clara


    are expressed in a fibre type-dependent manner and that fibre type-specific activation of AMPK and downstream targets is dependent on exercise intensity. Pools of type I and II fibres were prepared from biopsies of m. vastus lateralis from healthy men before and after two exercise trials; A) continuous cycling......AMP-activated protein kinase (AMPK) is a regulator of energy homeostasis during exercise. Studies suggest muscle fibre type-specific AMPK expression. However, fibre type-specific regulation of AMPK and downstream targets during exercise has not been proven. We hypothesized that AMPK subunits...... (CON) 30 min at 69 ± 1% VO2peak or B) interval cycling (INT) 30 min with 6 × 1.5 min high-intense bouts peaking at 95 ± 2% VO2peak . In type I vs. II fibres a higher β1 AMPK (+215%) and lower γ3 AMPK expression (-71%) was found. α1 , α2 , β2 and γ1 AMPK expression was similar between fibre types...

  16. Distinct roles for sequences upstream of and downstream from Physarum editing sites. (United States)

    Rhee, Amy C; Somerlot, Benjamin H; Parimi, Neeta; Gott, Jonatha M


    RNAs in the mitochondria of Physarum polycephalum contain nonencoded nucleotides that are added during RNA synthesis. Essentially all steady-state RNAs are accurately and fully edited, yet the signals guiding these precise nucleotide insertions are presently unknown. To localize the regions of the template that are required for editing, we constructed a series of chimeric templates that substitute varying amounts of DNA either upstream of or downstream from C insertion sites. Remarkably, all sequences necessary for C addition are contained within approximately 9 base pairs on either side of the insertion site. In addition, our data strongly suggest that sequences within this critical region affect different steps in the editing reaction. Template alterations upstream of an editing site influence nucleotide selection and/or insertion, while downstream changes affect editing site recognition and templated extension from the added, unpaired nucleotide. The data presented here provide the first evidence that individual regions of the DNA template play discrete mechanistic roles and represent a crucial initial step toward defining the source of the editing specificity in Physarum mitochondria. In addition, these findings have mechanistic implications regarding the potential involvement of the mitochondrial RNA polymerase in the editing reaction.

  17. Trehalose-6-phosphate synthesis controls yeast gluconeogenesis downstream and independent of SNF1. (United States)

    Deroover, Sofie; Ghillebert, Ruben; Broeckx, Tom; Winderickx, Joris; Rolland, Filip


    Trehalose-6-P (T6P), an intermediate of trehalose biosynthesis, was identified as an important regulator of yeast sugar metabolism and signaling. tps1Δ mutants, deficient in T6P synthesis (TPS), are unable to grow on rapidly fermentable medium with uncontrolled influx in glycolysis, depletion of ATP and accumulation of sugar phosphates. However, the exact molecular mechanisms involved are not fully understood. We show that SNF1 deletion restores the tps1Δ growth defect on glucose, suggesting that lack of TPS hampers inactivation of SNF1 or SNF1-regulated processes. In addition to alternative, non-fermentable carbon metabolism, SNF1 controls two major processes: respiration and gluconeogenesis. The tps1Δ defect appears to be specifically associated with deficient inhibition of gluconeogenesis, indicating more downstream effects. Consistently, Snf1 dephosphorylation and inactivation on glucose medium are not affected, as confirmed with an in vivo Snf1 activity reporter. Detailed analysis shows that gluconeogenic Pck1 and Fbp1 expression, protein levels and activity are not repressed upon glucose addition to tps1Δ cells, suggesting a link between the metabolic defect and persistent gluconeogenesis. While SNF1 is essential for induction of gluconeogenesis, T6P/TPS is required for inactivation of gluconeogenesis in the presence of glucose, downstream and independent of SNF1 activity and the Cat8 and Sip4 transcription factors. © FEMS 2016. All rights reserved. For permissions, please e-mail:

  18. Comparison of Flow Structures in the Downstream Region of a Cylinder with Flexible Strip (United States)

    Tekşin, Süleyman; Yayla, Sedat


    The present study investigates the details of flow structure to downstream of a circular cylinder mounted on a flat surface, in successive plan-view plane both in the boundary layer and up level region. The behavior of the flow in the wake of the bare cylinder and attached a flexible strip which has a 1400 N/mm2 modulus of elasticity vinyl PVC transperent film. The length of strip 240 mm (L/D=4) is investigated using Particle Image Velocimetry (PIV) technique for Reynolds numbers based on the cylinder diameter of 2500. The flow data downstream of the cylinder are presented using time-averaged velocity vector map, Vavg, streamline patterns, ψavg, vorticity contours, ωavg, and Reynolds stress correlations, u'u' avg, v'v' avg, u'v' avg and rms velocity values. The locations of the peak values of Reynolds stress correlations and other data are also presented in both bare cylinder and attached body in order to determine the regions under high fluctuations. Another L/D ratios will be investigated in other experiments.

  19. Evaluating lignocellulosic biomass, its derivatives, and downstream products with Raman spectroscopy. (United States)

    Lupoi, Jason S; Gjersing, Erica; Davis, Mark F


    The creation of fuels, chemicals, and materials from plants can aid in replacing products fabricated from non-renewable energy sources. Before using biomass in downstream applications, it must be characterized to assess chemical traits, such as cellulose, lignin, or lignin monomer content, or the sugars released following an acid or enzymatic hydrolysis. The measurement of these traits allows researchers to gage the recalcitrance of the plants and develop efficient deconstruction strategies to maximize yields. Standard methods for assessing biomass phenotypes often have experimental protocols that limit their use for screening sizeable numbers of plant species. Raman spectroscopy, a non-destructive, non-invasive vibrational spectroscopy technique, is capable of providing qualitative, structural information and quantitative measurements. Applications of Raman spectroscopy have aided in alleviating the constraints of standard methods by coupling spectral data with multivariate analysis to construct models capable of predicting analytes. Hydrolysis and fermentation products, such as glucose and ethanol, can be quantified off-, at-, or on-line. Raman imaging has enabled researchers to develop a visual understanding of reactions, such as different pretreatment strategies, in real-time, while also providing integral chemical information. This review provides an overview of what Raman spectroscopy is, and how it has been applied to the analysis of whole lignocellulosic biomass, its derivatives, and downstream process monitoring.

  20. Tryptophan Metabolism Along the Kynurenine Pathway Downstream of Toll-like Receptor Stimulation in Peripheral Monocytes. (United States)

    Orhan, F; Bhat, M; Sandberg, K; Ståhl, S; Piehl, F; Svensson, C; Erhardt, S; Schwieler, L


    Tryptophan degradation along the kynurenine pathway is of central importance for the immune function. Toll-like receptors (TLRs), representing the first line of immune defence against pathogens, are expressed in various cell types. The most abundant expression is found on monocytes, macrophages and dendritic cells. The aim of this study was to investigate whether stimulation with different TLR ligands induces the kynurenine pathway in human peripheral monocytes. Cell supernatants were analysed using a liquid chromatography/mass spectrometry to measure kynurenine, kynurenic acid (KYNA), quinolinic acid (QUIN) and tryptophan. Stimulation of TLR-2, TLR-3, TLR-4, TLR-7/8 and TLR-9 was found to induce the production of kynurenine, but only stimulation of TLR-3 increased levels of further downstream metabolites, such as KYNA and QUIN. Stimulation of TLR-1, TLR-5 and TLR-6 did not induce the kynurenine pathway. Taken together, this study provides novel evidence demonstrating that TLR activation induces a pattern of downstream tryptophan degradation along the kynurenine pathway in monocytes. The results of this study may implicate that TLRs can be used as new drug targets for the regulation of aberrant tryptophan metabolism along this pathway, a potential therapeutic strategy that may be of importance in several disorders. © 2016 The Foundation for the Scandinavian Journal of Immunology.

  1. Channel erosion in a rapidly urbanizing region of Tijuana, Mexico: Enlargement downstream of channel hardpoints (United States)

    Taniguchi, Kristine; Biggs, Trent; Langendoen, Eddy; Castillo, Carlos; Gudiño, Napoleon; Yuan, Yongping; Liden, Douglas


    Urban-induced erosion in Tijuana, Mexico, has led to excessive sediment deposition in the Tijuana Estuary in the United States. Urban areas in developing countries, in contrast to developed countries, are characterized by much lower proportions of vegetation and impervious surfaces due to limited access to urban services such as road paving and landscaping, and larger proportions of exposed soils. In developing countries, traditional watershed scale variables such as impervious surfaces may not be good predictors of channel enlargement. In this research, we surveyed the stream channel network of an erodible tributary of the Tijuana River Watershed, Los Laureles Canyon, at 125 locations, including repeat surveys from 2008. Structure from Motion (SfM) and 3D photo-reconstruction techniques were used to create digital terrain models of stream reaches upstream and downstream of channel hardpoints. Channels are unstable downstream of hardpoints, with incision up to 2 meters and widening up to 12 meters. Coordinated channelization is essential to avoid piece-meal approaches that lead to channel degradation. Watershed impervious area is not a good predictor of channel erosion due to the overriding importance of hardpoints and likely to the high sediment supply from the unpaved roads which prevents channel erosion throughout the stream network.

  2. Pharmacological therapeutics targeting the secondary defects and downstream pathology of Duchenne muscular dystrophy (United States)

    Spinazzola, Janelle M.; Kunkel, Louis M.


    Introduction Since the identification of the dystrophin gene in 1986, a cure for Duchenne muscular dystrophy (DMD) has yet to be discovered. Presently, there are a number of genetic-based therapies in development aimed at restoration and/or repair of the primary defect. However, growing understanding of the pathophysiological consequences of dystrophin absence has revealed several promising downstream targets for the development of therapeutics. Areas covered In this review, we discuss various strategies for DMD therapy targeting downstream consequences of dystrophin absence including loss of muscle mass, inflammation, fibrosis, calcium overload, oxidative stress, and ischemia. The rationale of each approach and the efficacy of drugs in preclinical and clinical studies are discussed. Expert opinion For the last 30 years, effective DMD drug therapy has been limited to corticosteroids, which are associated with a number of negative side effects. Our knowledge of the consequences of dystrophin absence that contribute to DMD pathology has revealed several potential therapeutic targets. Some of these approaches may have potential to improve or slow disease progression independently or in combination with genetic-based approaches. The applicability of these pharmacological therapies to DMD patients irrespective of their genetic mutation, as well as the potential benefits even for advanced stage patients warrants their continued investigation. PMID:28670506

  3. Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish.

    Directory of Open Access Journals (Sweden)

    Gustavo A Gomez

    Full Text Available The transcription factor Etsrp is required for vasculogenesis and primitive myelopoiesis in zebrafish. When ectopically expressed, etsrp is sufficient to induce the expression of many vascular and myeloid genes in zebrafish. The mammalian homolog of etsrp, ER71/Etv2, is also essential for vascular and hematopoietic development. To identify genes downstream of etsrp, gain-of-function experiments were performed for etsrp in zebrafish embryos followed by transcription profile analysis by microarray. Subsequent in vivo expression studies resulted in the identification of fourteen genes with blood and/or vascular expression, six of these being completely novel. Regulation of these genes by etsrp was confirmed by ectopic induction in etsrp overexpressing embryos and decreased expression in etsrp deficient embryos. Additional functional analysis of two newly discovered genes, hapln1b and sh3gl3, demonstrates their importance in embryonic vascular development. The results described here identify a group of genes downstream of etsrp likely to be critical for vascular and/or myeloid development.

  4. Estimating the wake deflection downstream of a wind turbine in different atmospheric stabilities: an LES study

    Directory of Open Access Journals (Sweden)

    L. Vollmer


    Full Text Available An intentional yaw misalignment of wind turbines is currently discussed as one possibility to increase the overall energy yield of wind farms. The idea behind this control is to decrease wake losses of downstream turbines by altering the wake trajectory of the controlled upwind turbines. For an application of such an operational control, precise knowledge about the inflow wind conditions, the magnitude of wake deflection by a yawed turbine and the propagation of the wake is crucial. The dependency of the wake deflection on the ambient wind conditions as well as the uncertainty of its trajectory are not sufficiently covered in current wind farm control models. In this study we analyze multiple sources that contribute to the uncertainty of the estimation of the wake deflection downstream of yawed wind turbines in different ambient wind conditions. We find that the wake shapes and the magnitude of deflection differ in the three evaluated atmospheric boundary layers of neutral, stable and unstable thermal stability. Uncertainty in the wake deflection estimation increases for smaller temporal averaging intervals. We also consider the choice of the method to define the wake center as a source of uncertainty as it modifies the result. The variance of the wake deflection estimation increases with decreasing atmospheric stability. Control of the wake position in a highly convective environment is therefore not recommended.

  5. Influence of Copper Ore Comminution in HPGR on Downstream Minerallurgical Processes

    Directory of Open Access Journals (Sweden)

    Saramak D.


    Full Text Available Crushing processes taking place in high-pressure grinding rolls devices (HPGR are currently one of the most efficient methods of hard ore size reduction in terms of the energy consumption. The HPGR products are characterized by a fine particle size and the micro-cracks formation in individual particles, which appears in downstream grinding processes, decreasing their energy consumption. The purpose of the paper was to analyze the effectiveness of a ball mill grinding process and flotation operations depending on the changeable conditions of run of the HPGR crushing process. The research programme carried out included crushing tests in the laboratory scale HPGR device at various settings of the operating pressure volume and selected qualitative properties of the feed material (i.e. particle size distribution. On the basis of obtained results the models, defining the grinding process effectiveness as a function of changeable conditions of HPGR process run, were determined. Based on these models the optimal grinding time in a ball mill was specified which is, in turn, the basis for optimization of operation the technological comminution circuits for a given material type. The obtained results proved that the application of HPGR devices in given copper ore comminution circuit may improve the effectiveness of downstream grinding process what leads to improvement of the entire circuit work efficiency through decreasing the process energy consumption and enhancing the product size reduction.

  6. Detection of argan oil adulterated with vegetable oils: new markers

    National Research Council Canada - National Science Library

    Ourrach, I; Rada, M; Pérez-Camino, M. C; Benaissa, M; Guinda, Á


    ... 5% with refined, sunflower and virgin olive oils. Due to the similarity of the fatty acid compositions of the edible oils studied and argan oil, fatty acids can be employed as markers for the detection...

  7. The European Social Survey and European research policy

    DEFF Research Database (Denmark)

    Kropp, Kristoffer


    This article analyses the history of the European Social Survey (ESS) and its relationship to changes in European research policy, using Bourdieu’s field-analytical approach. It argues that the success of the ESS relied on three interwoven processes that we can understand theoretically in terms o...

  8. Can the European Central Bank Create a European identity?

    DEFF Research Database (Denmark)

    Ravn Sørensen, Anders


    In what ways do central banks construct community, and how may the European Central Bank (ECB) contribute to a supranational European identity? In this paper I seek to answer these two questions by developing a conceptual framework for the ways that central banks construct national identities and...

  9. The Impact of Impoundment on Mercury Bioaccumulation in Fish Downstream from a Newly Constructed Reservoir, Wujiang River, Southwest China. (United States)

    Li, Sixin; Zhou, Lianfeng; Chang, Jianbo; Yang, Zhi; Hu, Juxiang; Hongjun, Wang


    Mercury concentrations in fish were investigated downstream from a newly impounded subtropical reservoir in August 2008. After 6-7 months of reservoir impoundment, mean mercury concentration in fish from downstream is significantly increased by 1.9 times. Not only carnivorous fish but also benthic fish had significantly higher total mercury concentrations than others. No significant correlation was found between total mercury concentrations and body length or weight of 13 fish species. Compared with the pre-impoundment, total mercury in fish from downstream is significantly increased by reservoir impoundment, but the increased rate is lower than those in subarctic and temperate areas. Fish samples surpassed the Chinese hygienic standard for tolerances of mercury in foods increased by 4.3%. More attention should be given to fish mercury levels from downstream sites to prevent possible adverse effects on the health of local people.

  10. MASH test 3-37 of the TxDOT 31-inch W-beam downstream anchor terminal. (United States)


    The objective of this study was to develop a suitable replacement for the downstream turndown : guardrail anchor system. The turndown guardrail anchor system does not meet mandated test requirements : under MASH for upstream anchor applic...

  11. Draft Scientific Report Connectivity of Streams and Wetlands to Downstream Waters: A Review and Synthesis of the Scientific Evidence (United States)

    Synthesizes peer-reviewed scientific literature on the biological, chemical, and hydrologic connectivity of waters and the effects that small streams, wetlands, and open waters have on larger downstream waters such as rivers, lakes, estuaries, and oceans.

  12. Rectors of European universities

    CERN Multimedia

    Maximilien Brice


    Several rectors of European universities visited CERN recently while in Geneva for a conference on coordination between their institutions. The visit began with a welcome by Roger Cashmore, CERN Director of Collider Programmes,and continued with tours of CMS, ALICE and the LHC magnet assembly hall. Photos 01, 02: The visitors in the ALICE assembly hall: (left to right) Dr. Raymond Werlen, Deputy Secretary-General of the Conference of Rectors of Swiss Universities; visit guide Prof. Alain Blondel, Department of Nuclear and Corpuscular Physics, University of Geneva; Prof. Adriano Pimpão, Rector of the University of Algarve, President of the Council of Rectors of Portuguese Universities; Prof. Jean-Pierre Finance, Conference of University Presidents, France; Prof. Jean-Paul Lehners, Vice-President of the Centre Universitaire, Luxemburg.

  13. Characterizing European cultural landscapes

    DEFF Research Database (Denmark)

    Tieskens, Koen F.; Schulp, Catharina J E; Levers, Christian


    Almost all rural areas in Europe have been shaped or altered by humans and can be considered cultural landscapes, many of which now are considered to entail valuable cultural heritage. Current dynamics in land management have put cultural landscapes under a huge pressure of agricultural...... intensification and land abandonment. To prevent the loss of cultural landscapes, knowledge on the location of different types of cultural landscapes is needed. In this paper, we present a characterization of European cultural landscapes based on the prevalence of three key dimensions of cultural landscapes......: landscape structure, management intensity, and value and meaning. We mapped these dimensions across Europe at a 1-km resolution by combining proxies on management intensity and landscape structure with new indicators such as social media usage and registered traditional food products. We integrated...

  14. Credit and Oil Consumption


    Arora, Vipin


    Credit greases the wheels of oil consumption—it is prevalent in purchases of cars, trucks, and even the construction of factories. But the traditional view is that it affects oil consumption only through economic activity and the price of oil. I argue that credit is important in its own right. To make my case, I first show that an association between credit and oil consumption growth exists across countries and time. I then give a nod to the traditional view, and conclude by showing that ...

  15. European project ISAWARE (United States)

    Kaiser, Jochen; Smietanski, Guillaume; Kubbat, Wolfgang


    As air traffic is increasing, the probability of encountering 'surveillance' alerts during flight is also increasing. In order to ensure safety, new on board systems need to be developed to provide the crew with a better 'situation awareness' (SA) about its external environment and potential hazards. In addition, the means to manage the data generated by these new systems needs to be build up. Despite the tremendous amount of information, crew workload must not increase. This is where the ISAWARE project comes in with the Integrated Situation Awareness System (ISAS) concept. ISAWARE (Increasing Safety through collision Avoidance WARning intEgration) is a project partly funded by the European Community, executed by a well balanced composition of several European aerospace companies (airframers, a helicopter manufacturer, avionics suppliers, airlines), one research laboratory and one university. The overall objective of the ISAWARE project is to conduct research into the potential improvements to flight safety that can be achieved by providing the pilot with complete predictive situation awareness during all phases of the flight. The Integrated Situational Awareness System (ISAS) merges data from different safety systems concerning terrain, traffic, weather and other. The system ensures the alerts consistency, prioritises alerts and anticipates threats along a predicted trajectory earlier than current systems can provide. The second main axis of the research is the development of synthetic vision displays (PFD, ND and HUD) to enhance the Human-Machine Interface (HMI). The key focus of the project is the development of a ground-based demonstrator rig which is interfaced to a dynamic flight simulator. This rig is used for the evaluation of the ISAWARE concept by a representative range of active airline crews.

  16. Integrated Optimization of Upstream and Downstream Processing in Biopharmaceutical Manufacturing under Uncertainty: A Chance Constrained Programming Approach


    Liu, S.; Farid, S. S.; Papageorgiou, L. G.


    This work addresses the integrated optimization of upstream and downstream processing strategies of a monoclonal antibody (mAb) under uncertainty. In the upstream processing (USP), the bioreactor sizing strategies are optimized, while in the downstream processing (DSP), the chromatography sequencing and column sizing strategies, including the resin at each chromatography step, the number of columns, the column diameter and bed height, and the number of cycles per batch, are determined. Meanwh...

  17. Enhanced Oil Recovery with CO2 Capture and Sequestration

    Energy Technology Data Exchange (ETDEWEB)

    Andrei, Maria; De Simoni, Michela; Delbianco, Alberto; Cazzani, Piero; Zanibelli, Laura


    This paper presents the results of a feasibility study aimed at extending the production life of a small oilfield in Italy through EOR, employing the CO2 captured from the flue gas streams of the refinery nearby. The EOR operation allows the recovery of additional reserves while a consistent amount of the CO2 injected remains permanently stored into the reservoir. The screening process selection for EOR-CO2 and the main elements of the pilot project for the proper upstream-downstream integration will be described. Evaluation of EOR-CO2 extension to other oilfields and its effect on oil production and project's economics will be reported.

  18. Single-laboratory validation of a GC/MS method for the determination of 27 polycyclic aromatic hydrocarbons (PAHs) in oils and fats. (United States)

    Rose, M; White, S; Macarthur, R; Petch, R G; Holland, J; Damant, A P


    A protocol for the measurement of 27 polycyclic aromatic hydrocarbons (PAHs) in vegetable oils by GC/MS has undergone single-laboratory validation. PAHs were measured in three oils (olive pomace, sunflower and coconut oil). Five samples of each oil (one unfortified, and four fortified at concentrations between 2 and 50 microg kg(-1)) were analysed in replicate (four times in separate runs). Two samples (one unfortified and one fortified at 2 microg kg(-1)) of five oils (virgin olive oil, grapeseed oil, toasted sesame oil, olive margarine and palm oil) were also analysed. The validation included an assessment of measurement bias from the results of 120 measurements of a certified reference material (coconut oil BCR CRM458 certified for six PAHs). The method is capable of reliably detecting 26 out of 27 PAHs, at concentration <2 microg kg(-1) which is the European Union maximum limit for benzo[a]pyrene, in vegetable oils, olive pomace oil, sunflower oil and coconut oil. Quantitative results were obtained that are fit for purpose for concentrations from <2 to 50 microg kg(-1) for 24 out of 27 PAHs in olive pomace oil, sunflower oil and coconut oil. The reliable detection of 2 microg kg(-1) of PAHs in five additional oils (virgin olive oil, grapeseed oil, toasted sesame oil, olive margarine and palm oil) has been demonstrated. The method failed to produce fit-for-purpose results for the measurement of dibenzo[a,h]pyrene, anthanthrene and cyclopenta[c,d]pyrene. The reason for the failure was the large variation in results. The likely cause was the lack of availability of (13)C isotope internal standards for these PAHs at the time of the study. The protocol has been shown to be fit-for-purpose and is suitable for formal validation by inter-laboratory collaborative study.

  19. A toolbox for European judges

    NARCIS (Netherlands)

    Hesselink, M.W.


    The forthcoming instrument on European contract law, be it in the shape of an optional code for cross-border contracts or as an official toolbox for the European legislator, is likely to have a spill-over effect on private law adjudication in Europe. Judges will have no great difficulty in finding

  20. Getting European universities into shape

    NARCIS (Netherlands)

    Jacobs, B.; van der Ploeg, F.


    Most European universities lag behind the best universities in the Anglo-Saxon world. A key challenge is to raise resources per student in Europe to US levels. The Lisbon agenda demands fundamental reform of the European university system in order to enhance efficiency, yet avoid grade inflation, to

  1. European Industry, 1700-1870

    NARCIS (Netherlands)

    Broadberry, Stephen; Fremdling, Rainer; Solar, Peter M.


    This paper offers an overview of the development of European industry between 1700 and 1870, drawing in particular on the recent literature that has emerged following the formation of the European Historical Economics Society in 1991. The approach thus makes use of economic analysis and quantitative

  2. Developments in European Civil Procedures

    NARCIS (Netherlands)

    Cortés, P.; Mańko, R.; Cortés, P.


    This chapter is structured as follows. In Section B we explore the legal basis for the creation of European civil procedures and Europeanization of procedural private law in general. In Section C we provide an overview of existing EU instruments on civil procedure, which we propose to divide into

  3. Third European Stroke Science Workshop

    NARCIS (Netherlands)

    Dichgans, Martin; Planas, Anna M.; Biessels, Geert Jan|info:eu-repo/dai/nl/165576367; van der Worp, Bart|info:eu-repo/dai/nl/189855010; Sudlow, Cathie; Norrving, B.; Lees, Kennedy; Mattle, Heinrich P.


    Lake Eibsee, Garmisch-Partenkirchen, November 19 to 21, 2015: The European Stroke Organization convened >120 stroke experts from 27 countries to discuss latest results and hot topics in clinical, translational, and basic stroke research. Since its inception in 2011, the European Stroke Science

  4. Carbon accumulation in European forests

    NARCIS (Netherlands)

    Ciais, P.; Schelhaas, M.J.; Zaehle, S.; Piao, S.L.; Cescatti, A.; Liski, J.; Luyssaert, S.; Le-Maire, G.; Schulze, E.D.; Bouriaud, O.; Freibauer, A.; Valentini, R.; Nabuurs, G.J.


    European forests are intensively exploited for wood products, yet they also form a sink for carbon. European forest inventories, available for the past 50 years, can be combined with timber harvest statistics to assess changes in this carbon sink. Analysis of these data sets between 1950 and 2000

  5. Adult Education and European Identity (United States)

    Negt, Oskar


    Europe is coming together. This is a historic project; for the first time in modern history, will and consciousness are used for bringing political, social and cultural unity to the European continent. In this process lifelong learning and hence adult education are gaining in importance. The European project takes place in an age characterised by…

  6. Ranking the European armed forces

    NARCIS (Netherlands)

    Beeres, R.J.M.; Bogers, M.


    The degree of collectiveness aimed for in European defence policy raises issues such as burden sharing and relative performance measurement of the European Armed Forces (EAF). This paper compares EAF performance rates on three dimensions: input, throughput and output. In order to express

  7. The Ideology of European Dominance. (United States)

    Richards, Dona


    Describes the evolution of anthropology as a particular manifestation of western European culture. Examines the political implications of the discipline's roots in European intellectual, social, and emotional thought, and discusses the role of Black anthropologists in creating a new anthropology for the redefinition of African peoples. (Author/GC)

  8. The Europeanization of National Judiciaries

    DEFF Research Database (Denmark)

    Jaremba, Urszula; Mayoral, Juan A.


    The article is underpinned by the idea that the national courts/judges are expected to act as decentralized European Union judges. However, the general knowledge concerning the impact of EU law on the functioning of national courts as EU judges and the process of Europeanization of national judic...

  9. Action Research in European perspective

    DEFF Research Database (Denmark)

    Rasmussen, Lauge Baungaard


    The article gives an overview of how different Italian and Danish contributions to action research can be viewed in an European perspective.......The article gives an overview of how different Italian and Danish contributions to action research can be viewed in an European perspective....

  10. Market forces in european soccer

    NARCIS (Netherlands)

    Haan, M.; Koning, Ruud H.; Witteloostuijn, A. van


    Recent decades have witnessed major changes in the market for European soccer. The most profound were the Bosman ruling, which lifted restrictions in the European labor market for soccer talent, and the introduction of the Champions' League, a high-profile international competition that generates

  11. Market forces in european soccer

    NARCIS (Netherlands)

    Haan, M.; Koning, Ruud H.; Witteloostuijn, A. van


    Recent decades have witnessed major changes in the market for European soccer. The most profound were the Bosman ruling, which lifted restrictions in the European labor market for soccer talent, and the introduction of the Champions' League, a high-profile international competition that generates

  12. Downstream changes in spring-fed stream invertebrate communities: the effect of increased temperature range?

    Directory of Open Access Journals (Sweden)

    Russell G. DEATH


    Full Text Available Reduced thermal amplitude has been highlighted as a limiting factor for aquatic invertebrate diversity in springs. Moving downstream water temperature range increases and invertebrate richness is expected to change accordingly. In the present study temperature patterns were investigated in seven spring-fed streams, between April 2001 and November 2002, and compared to five run-off-fed streams to assess the degree of crenic temperature constancy. Temperature and physico-chemical characteristics of the water, and food resource levels were measured, and the invertebrate fauna collected at 4 distances (0, 100, 500 m and 1 km from seven springs in the North and South Islands of New Zealand. Temperature variability was greater for run-off-fed streams than for springs, and increased in the spring-fed streams with distance from the source. Periphyton and physico-chemical characteristics of the water did not change markedly over the 1 km studied, with the exception of water velocity and organic matter biomass, which increased and decreased, respectively. The rate of increase in temperature amplitude differed greatly for the studied springs, probably being affected by flow, altitude, and the number and type of tributaries (i.e., spring- or run-off-fed joining the spring-fed stream channel. Longitudinal changes in the number and evenness of invertebrate taxa were positively correlated to thermal amplitude (rs = 0.8. Moving downstream, invertebrate communities progressively incorporated taxa with higher mobility and taxa more common in nearby run-off-fed streams. Chironomids and non-insect taxa were denser at the sources. Chironomid larvae also numerically dominated communities 100 and 500 m downstream from the sources, together with Pycnocentria spp. and Zelolessica spp., while taxa such as Hydora sp. and Hydraenidae beetles, the mayflies Deleatidium spp. and Coloburiscus humeralis, and the Trichoptera Pycnocentrodes spp., all had greater abundances 1 km

  13. Overview of the North Atlantic Waveguide and Downstream Impact Experiment (NAWDEX) (United States)

    Schäfler, Andreas; Craig, George; Ament, Felix; Arbogast, Philippe; Crewell, Susanne; Doyle, James D.; Hirsch, Lutz; Mayer, Bernhard; McTaggart-Cowan, Ron; Methven, John; Rahm, Stephan; Reitebuch, Oliver; Rivière, Gwendal; Vaughan, Geraint; Wendisch, Manfred; Wernli, Heini; Wirth, Martin; Witschas, Benjamin


    The North Atlantic Waveguide and Downstream Impact Experiment (NAWDEX) was a highly successful field campaign conducted from 19 September to 18 October 2016. The main aims of NAWDEX are to increase the physical understanding and to quantify the effects of diabatic processes on jet stream disturbances and their consequences for downstream predictability and high-impact weather in the mid-latitudes. One of the crucial processes for the correct prediction of the mid-latitude circulation is the release of latent heat in clouds that are driven by large-scale motions in extratropical cyclones. A focus will be put on early research highlights with a demonstration of the unique capability of the suite of instruments deployed during NAWDEX to observe mid-latitude cloud systems. We present the favorable general synoptic situation during the campaign period that was characterized by a series of deep low pressure systems that continuously moved towards Iceland. NAWDEX was an international field experiment involving scientists from Europe and North America performing airborne observations onboard four research aircraft (German HALO and Falcon, French Falcon, UK BAE-146) over the North Atlantic and Europe. We will give an overview on the observations of water vapor, temperature, wind, clouds and precipitation in numerous jet stream disturbances featuring active diabatic processes. The research aircraft HALO and Falcon used a state-of-the-art remote sensing payload that was deployed to perform observations for the NAWDEX aims and to support the preparation of the future satellite missions ADM-Aeolus and EarthCARE. The aircraft coordination and the support by ground-based observations allowed a unique data set to be obtained, containing a number of observational highlights. The aircraft operated from Iceland over the air traffic-dense North Atlantic in situations with limited predictability, which required focused forecasting and flight planning strategies. For the first time

  14. Predation on juvenile pacific salmon oncorhynchus spp. in downstream migrant traps in prairie creek, california (United States)

    Duffy, W.G.; Bjorkstedt, E.P.; Ellings, C.S.


    Downstream migrant traps are a widely applied fishery management tool for sampling anadromous Pacific salmon Oncorhynchus spp. and steelhead O. mykiss smolts along theWest Coast of North America and elsewhere, yet predation on juvenile salmonids in traps has not been studied quantitatively.We assessed the frequency of occurrence and abundance of juvenile salmonids in the stomachs of coastal cutthroat trout O. clarkii clarkii, coho salmon O. kisutch, steelhead, and prickly sculpin Cottus asper (>70 mm fork length) captured in traps and in nearby stream habitats. All four predator species took juvenile salmonids with much greater frequency in traps than in stream habitats. Among free-swimming predators, only coastal cutthroat trout were observed with salmonid fry in their stomachs, but they took fewer salmonid prey and appeared to rely more heavily on insect prey than did coastal cutthroat trout captured in traps. Predators consumed up to 25% of the available prey over a broad range of prey abundances. Over the course of the study, predators consumed 2.5% of all salmonid fry captured in traps, but this fraction ranged from less than 1% to more than 10% in any given year. The number of prey taken in traps increased with predator length and with prey abundance in traps, and predation in traps peaked during the period of most intense downstream migration by salmon fry. In contrast, live-box design and trap location had little or no effect on the total number of prey taken by individual predators.We estimated that the predation mortality of juvenile salmon increased by 0.5-1.0% due to in-trap predation (i.e., a 9-10% relative increase over natural predation rates). We found no evidence that predators selected for prey on the basis of species. These results should motivate additional research on methods that reduce or eliminate predation in trap live-boxes and protocols for efficiently measuring predation associated with the trapping of downstream migrants. ?? American

  15. Political Psychology of European Integration

    DEFF Research Database (Denmark)

    Manners, Ian James


    The chapter engages in a survey of what political psychology and European integration have to say to each other in the understanding of the European Union. The chapter draws on five strands of political psychology as part of this engagement – conventional psychology, social psychology, social...... construction, psychoanalysis, and critical political psychology. Within each strand a number of examples of scholarship at the interface of political psychology and European integration are examined. The chapter argues that the study of the EU has much to benefit from political psychology in terms of theories...... and methods of European identity and integration, but it also argues that political psychology can benefit from the insights of European integration by rethinking the processes that drive the marking of inside and outside, interior and exterior, belonging and otherness....

  16. Denmark and the European Union

    DEFF Research Database (Denmark)

    Manners, Ian


    Over the past two decades Morten Kelstrup’s work has been at the centre of three important intellectual innovations in political science – the study of the EU as a regional political system; European security studies; and small states in European integration. Kelstrup’s best known books (Buzan, K...... of this book, two of Kelstrup’s most important intellectual contributions come from his work on Denmark’s relations with the European Union, and his use of systems theory to understand the EU.......Over the past two decades Morten Kelstrup’s work has been at the centre of three important intellectual innovations in political science – the study of the EU as a regional political system; European security studies; and small states in European integration. Kelstrup’s best known books (Buzan...


    Directory of Open Access Journals (Sweden)

    Cosmin Marinescu


    Full Text Available Recent evolutions in Europe raise questions on the viability of the present economic and social model that defines the European construction project. In this paper, the author will try to explain the viability of institutional European model that sticks between free market mechanisms and protectionism. The main challenge for the EU is about the possibility to bring together the institutional convergence and the welfare for all Europeans. This is the result of the view, still dominant, of European politics elite, according to which institutional harmonization is the solution of a more dynamic and prosper Europe. But, economic realities convince us that, more and more, a harmonized, standardized Europe is not necessarily identical with a Europe of harmony and social cooperation. If „development through integration” seems to be harmonization through „institutional transplant”, how could then be the European model one sufficiently wide open to market, which creates the prosperity so long waited for by new member countries?

  18. European environmental stratifications and typologies

    DEFF Research Database (Denmark)

    Hazeu, G.W,; Metzger, M.J.; Mücher, C.A.


    A range of new spatial datasets classifying the European environment has been constructed over the last few years. These datasets share the common objective of dividing European environmental gradients into convenient units, within which objects and variables of interest have relatively homogeneous...... characteristics. The stratifications and typologies can be used as a basis for up-scaling, for stratified random sampling of ecological resources, for the representative selection of sites for studies across the continent and for the provision of frameworks for modeling exercises and reporting at the European...... scale. This paper provides an overview of five recent European stratifications and typologies, constructed for contrasting objectives, and differing in spatial and thematic detail. These datasets are: the Environmental Stratification (EnS), the European Landscape Classification (LANMAP), the Spatial...

  19. Update: world refining investments. The love-hate affair with the downstream

    Energy Technology Data Exchange (ETDEWEB)


    While international attention is on recent crude price crash fears and moves to tie crude-oil supply with refined-product demand through joint ventures, the oil industry's processing sector could be seen as the beneficiary of both. That has been the case, short-term. But refiners are still in a painful squeeze between narrow margins and rising costs. Where will needed future capital for the refining sector come from. This dilemma is discussed, noting the present profit squeeze. This issue also presents the following: (1) ED refining netback data series for the US Gulf and West Coasts, Rotterdam, and Singapore as of Oct. 7, 1988; and (2) ED fuel price/tax series for countries of the Western Hemisphere, Oct. 1988 edition. 3 figures, 6 tables.

  20. Microalgae-based biodiesel: economic analysis of downstream process realistic scenarios. (United States)

    Ríos, Sergio D; Torres, Carmen M; Torras, Carles; Salvadó, Joan; Mateo-Sanz, Josep M; Jiménez, Laureano


    Microalgae oil has been identified as a reliable resource for biodiesel production due to its high lipid productivity and potential cultivation in non-fertile locations. However, high scale production of microalgae based biodiesel depends on the optimization of the entire process to be economically feasible. The selected strain, medium, harvesting methods, etc., sorely affects the ash content in the dry biomass which have a direct effect in the lipid content. Moreover, the suitable lipids for biodiesel production, some of the neutral/saponifiable, are only a fraction of the total ones (around 30% dry base biomass in the best case). The present work uses computational tools for the modeling of different scenarios of the harvesting, oil extraction and transesterification. This rigorous modeling approach detects process bottlenecks that could have led to an overestimation of the potentiality of the microalgae lipids as a resource for the biodiesel production. Copyright © 2013 Elsevier Ltd. All rights reserved.

  1. From upstream to downstream: Megatrends and latest developments in Latin America`s hydrocarbons sector

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Kang; Pezeshki, S.; McMahon, J.


    In recent years, Latin America`s hydrocarbons sector has been characterized by reorganization, revitalization, regional cooperation, environmental awakening, and steady expansion. The pattern of these changes, which appear to be the megatrends of the region`s hydrocarbons sector development, will continue during the rest of the 1990s. To further study the current situation and future prospects of Latin America`s hydrocarbons sector, we critically summarize in this short article the key issues in the region`s oil and gas development. These megatrends in Latin America`s hydrocarbons sector development will impact not only the future energy demand and supply in the region, but also global oil flows in the North American market and across the Pacific Ocean. Each country is individually discussed; pipelines to be constructed are discussed also.

  2. Road tunnels safety according to European legislation

    Directory of Open Access Journals (Sweden)

    Fedor KÁLLAY


    Full Text Available The article deals with safety of European road tunnels in accordance with actual European legislation. Standards and recommendations of European Commission, PIARC and other professional bodies of the European Union define minimal technological requirements for equipment and operation of the tunnels in scope of Trans-European Road Network.

  3. Oil spill statistics and oil spill monitoring

    Energy Technology Data Exchange (ETDEWEB)

    Viebahn, C. von [Greifswald Univ. (Germany). Dept. of Geography


    The main parts of the report describe the analysis and it's results of German and international oil spill data (North Sea and Baltic Sea). In order to improve the current oil spill monitoring of the Baltic Sea regarding oil spill data, the report proposes the establishment of a combined monitoring system; its suitability is shown on selected examples. This contains today's pollution control aircraft plus in-service aircraft and satellites. (orig.) [German] Der Schwerpunkt der Arbeit liegt in der Analyse von Daten ueber marine Oelschadensfaelle in deutschen und internationalen Gewaessern (Nord- und Ostsee). Um die heutige Ueberwachung der Ostsee im Hinblick auf Oelschadensfaelle zu verbessern, wird die Einrichtung eines kombinierten Ueberwachungssystems vorgeschlagen und dessen Eignung an ausgewaehlten Beispielen dargestellt. Dieses umfasst sowohl die heute eingesetzten Ueberwachungsflugzeuge sowie zusaetzlich Linienflugzeuge und Satelliten. (orig.)

  4. Evaluation of waterborne exposure to oil spill 5 years after an accident in Southern Brazil. (United States)

    Silva, C A; Oliveira Ribeiro, C A; Katsumiti, A; Araújo, M L P; Zandoná, E M; Costa Silva, G P; Maschio, J; Roche, H; Silva de Assis, H C


    Fish (Astyanax sp.) were exposed to water samples from the Arroio Saldanha, locality of an oil spill, and the Barigui River (upstream and downstream of the confluence of the river and Arroio Saldanha), Brazil. Histopathological and biochemical biomarkers, as acetylcholinesterase (AchE), ethoxyresorufin-O-deethylase (EROD), catalase (CAT), glutathione-S-transferase (GST) activities, lipid peroxidation (LPO) levels, and amounts of polynuclear aromatic hydrocarbon residues (PAHs) in bile were evaluated. PAHs, metals, and surfactants were investigated in the water samples. CAT and GST activities increased in the Arroio Saldanha sample, whereas CAT activity and LPO levels were increased in the upstream and downstream sites. The results suggested a toxic action of the free radicals and disturbance of the antioxidant defense mechanisms. However, the EROD and AchE activities were not affected. Histopathology studies showed severe lesions. The oil is still bioavailable to biota, moreover, other pollution sources continue to affect the water in the Barigui River.

  5. Oil supply and demand

    Energy Technology Data Exchange (ETDEWEB)

    Rech, O


    World oil demand, driven by economic development in China, posted the highest growth rate in 20 years. In a context of geopolitical uncertainty, prices are soaring, encouraged by low inventory and the low availability of residual production capacity. Will 2004 bring a change in the oil market paradigm? (author)

  6. Krill oil: new nutraceuticals

    Directory of Open Access Journals (Sweden)

    Beuy Joob


    Full Text Available Krill oil is a new available health product which is produced from deep marine species. Its property is to promote good health. The good lipid composition and antioxidant enrichment make krill oil a new nutraceutical for reducing health problems.

  7. Fossil Energy: Oil. (United States)

    Eaton, William W.

    Detailed are the highlights of the history and technology of crude oil and its end products. Included also are some of the important programs that American industry and the Federal government are planning and undertaking in order to enhance the benefits of oil and make use of the limited available quantities as wisely as possible, both now and in…

  8. Problems Caused by Microbes and Treatment Strategies Downstream Petroleum Microbiology - An Industry Perspective (United States)

    McFarlane, Elaine

    In the mid 1800's it was discovered that crude oil could be extracted and exploited to produce energy. However, it was the invention of the first four-stroke internal combustion engine in 1876 that transformed the petroleum industry from a localised to a global business (Dell and Rand, 2004). Crude oil is made into useable products at the refinery via separation, conversion and treatment processes. Separation starts with distillation where the crude is evaporated and condensed into fractions based on their boiling ranges (Fig. 19.1). As well as carbon and hydrogen, the fractions consist of sulphur, nitrogen and oxygen (present in low concentrations) and metals like copper and iron (in trace amounts). After separation, heavy fractions are converted into lighter ones using intense heat, pressure and a catalyst to speed up chemical reactions. Molecules like sulphur can then be stripped out by heat treatment under pressure with hydrogen. Injection of refinery additives makes a finished fuel. For example, static dissipator is added to Automotive Gas Oil (AGO) to reduce the risk of spark and explosion during fuel movements; middle distillate flow improver to improve low temperature operability and lubricity improver to lubricate engine components. Finally, fuel quality measurements are made to ensure that the finished fuel meets the relevant specification.

  9. Polar View Snow Service- Operational Snow Cover Mapping for Downstream Runoff Modeling and Hydropower Predictions (United States)

    Bach, Heike; Appel, Florian; Rust, Felix; Mauser, Wolfram


    Information on snow cover and snow properties are important for hydrology and runoff modelling. Frequent updates of snow cover observation, especially for areas characterized by short-term snow dynamics, can help to improve water balance and discharge calculations. Within the GMES service element Polar View, VISTA offers a snow mapping service for Central Europe since several years [1, 2]. We outline the use of this near-real- time product for hydrological applications in Alpine environment. In particular we discuss the integration of the Polar View product into a physically based hydrological model (PROMET). This allows not only the provision of snow equivalent values, but also enhances river runoff modelling and its use in hydropower energy yield prediction. The GMES snow products of Polar View are thus used in a downstream service for water resources management, providing information services for renewable energy suppliers and energy traders.

  10. Trends in the biomanufacture of polyhydroxyalkanoates with focus on downstream processing. (United States)

    Kosseva, Maria R; Rusbandi, Edy


    The aim of the current review is to analyze trends in development of an efficient technology for polyhydroxyalkanoate (PHA) biomanufacture highlighting the up-to-date progress on PHA biosynthesis and focusing on the downstream processing. Three main production pathways were identified: through microbial, enzymic, or plant routes. Microbial fermentation processes were predominant, with a wide range of microorganisms, starting materials and culture conditions reported. Largely, two schemes for recovering PHAs from the reaction medium post fermentation were identified: dissolving biomass to separate PHAs granules with strong oxidants, and extracting PHAs directly from the biomass using suitable solvents. For the valuable industrial scale biosynthesis of PHA several technological elements need to be applied such as robust whole-cell microbial catalyst with its optimal culturing conditions, suitable carbon source, proper mode of process operation, as well as economical and ecological purification methods. Copyright © 2017 Elsevier B.V. All rights reserved.

  11. Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling

    Directory of Open Access Journals (Sweden)

    Catríona M. Dowling


    Full Text Available The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment.

  12. Development of suitable solvent system for downstream processing of biopolymer pullulan using response surface methodology.

    Directory of Open Access Journals (Sweden)

    Anirban Roy Choudhury

    Full Text Available Downstream processing is an important aspect of all biotechnological processes and has significant implications on quality and yield of the final product. Several solvents were examined for their efficacy on pullulan precipitation from fermentation broth. Interactions among four selected solvents and their effect on pullulan yield were studied using response surface methodology. A polynomial model was developed using D-optimal design and three contour plots were generated by performing 20 different experiments and the model was validated by performing optimization experiments. The results indicated that lower concentration of ethanol in combination with the other three solvents has resulted in higher yield of polymer from fermentation broth and the optimized solvent system was able to recover 1.44 times more pullulan as compared to the conventional ethanolic precipitation method. These observations may help in enhancing efficiency of pullulan recovery from fermentation broth and also result in reduced cost of production for the final product.

  13. Assessing geomorphic change along the Trinity River downstream from Lewiston Dam, California, 1980-2011 (United States)

    Curtis, Jennifer A.; Wright, Scott A.; Minear, Justin T.; Flint, Lorraine E.


    The Trinity River Restoration Program, one of the nation’s largest adaptively managed river restoration programs, requires periodic assessment to determine the effectiveness of management actions in restoring channel dynamics and habitat features. This study documents riparian and channel changes along an intensively managed 65-kilometer reach of the Trinity River in California, downstream from Lewiston Dam. The two primary periods of interest, from 1980 to 2001 and from 2001 to 2011, are separated by a shift in restoration activities mandated by the U.S. Department of the Interior December 2000 Record of Decision. The post-2001 restoration strategy increased managed-flow releases, gravel augmentation, watershed restoration, and mechanical channel rehabilitation.

  14. Myosin II governs collective cell migration behaviour downstream of guidance receptor signalling. (United States)

    Combedazou, Anne; Choesmel-Cadamuro, Valérie; Gay, Guillaume; Liu, Jiaying; Dupré, Loïc; Ramel, Damien; Wang, Xiaobo


    Border cell migration during Drosophila oogenesis is a potent model to study collective cell migration, a process involved in development and metastasis. Border cell clusters adopt two main types of behaviour during migration: linear and rotational. However, the molecular mechanism controlling the switch from one to the other is unknown. Here, we demonstrate that non-muscle Myosin II (NMII, also known as Spaghetti squash) activity controls the linear-to-rotational switch. Furthermore, we show that the regulation of NMII takes place downstream of guidance receptor signalling and is critical to ensure efficient collective migration. This study thus provides new insight into the molecular mechanism coordinating the different cell behaviours in a migrating cluster. © 2017. Published by The Company of Biologists Ltd.

  15. Wastewater from the manufacture of rubber vulcanization accelerators: characterization, downstream monitoring and chemical treatment. (United States)

    Puig, A; Ormad, P; Roche, P; Sarasa, J; Gimeno, E; Ovelleiro, J L


    The content of wastewater resulting from the manufacture of rubber antioxidants and accelerators by a factory situated in the Ebro basin (Spain) has been determined using gas chromatography-mass spectrometry (GC-MS) and gas chromatography-flame ionization detection (GC-FID). The change in the pollutants was studied in the riverbed via two modules which continuously gathered pollutants on various solid supports (activated carbon and XAD-2 resins). These modules were located in Bocal Station, lying a further 100 km downstream from the factory, and from the Zaragoza water supply. Forty-six different compounds were identified at Bocal Station, the majority resulting from the production of rubber additives. Due to the immunity of different waste substances, and to the toxic nature of some, we studied their reaction when subjected to techniques of chemical oxidation using ozone.

  16. Sodic alkaline stress mitigation by exogenous melatonin in tomato needs nitric oxide as a downstream signal. (United States)

    Liu, Na; Gong, Biao; Jin, Zhiyong; Wang, Xiufeng; Wei, Min; Yang, Fengjuan; Li, Yan; Shi, Qinghua


    The present study was designed to determine the interactive effect of exogenous melatonin and nitric oxide (NO) on sodic alkaline stress mitigation in tomato seedlings. It was observed that exogenous melatonin treatment elevated NO levels in alkaline-stressed tomato roots. However, exogenous NO had little effects on melatonin levels. Importantly, melatonin-induced NO generation was accompanied by increased tolerance to alkaline stress. Chemical scavenging of NO reduced melatonin-induced alkaline stress tolerance and defense genes' expression. However, inhibition of melatonin biosynthesis had a little effect on NO-induced alkaline stress tolerance. These results strongly suggest that NO, acting as a downstream signal, is involved in the melatonin-induced tomato tolerance to alkaline stress. This process creates a new signaling pathway for improving stress tolerance in plant. Copyright © 2015 Elsevier GmbH. All rights reserved.

  17. Corporate Governance and Human Resource Management in Nigeria’s Downstream Petroleum Sector

    Directory of Open Access Journals (Sweden)

    Oyewunmi Olabode A.


    Full Text Available The emergence of a ‘new world economy’ makes it imperative for corporate entities to adjust their corporate values, practices and internal processes. This paper explored the interrelatedness of selected corporate governance practices and human resource management outcomes. The paper relied on established corporate management theories as a platform for empirical consideration of selected issues relative to four established players in Nigeria’s downstream petroleum sector. A descriptive method was adopted and data was collected via a survey of 112 respondents. Contextual arguments were captured to achieve a robust appreciation of issues affecting individual participation and operations of corporate entities. The study found that there is a significant relationship between corporate governance practices and human resource management outcomes. Requisite conclusions and recommendations were provided in the light of empirical and theoretical findings.

  18. Targeting Protein Kinase C Downstream of Growth Factor and Adhesion Signalling

    Energy Technology Data Exchange (ETDEWEB)

    Dowling, Catríona M., E-mail:; Kiely, Patrick A., E-mail: [Department of Life Sciences, Materials and Surface Science Institute and Stokes Institute, University of Limerick, Limerick 78666 (Ireland); Health Research Institute (HRI), University of Limerick, Limerick 78666 (Ireland)


    The signaling outputs of Receptor Tyrosine Kinases, G-protein coupled receptors and integrins converge to mediate key cell process such as cell adhesion, cell migration, cell invasion and cell proliferation. Once activated by their ligands, these cell surface proteins recruit and direct a diverse range of proteins to disseminate the appropriate response downstream of the specific environmental cues. One of the key groups of proteins required to regulate these activities is the family of serine/threonine intracellular kinases called Protein Kinase Cs. The activity and subcellular location of PKCs are mediated by a series of tightly regulated events and is dependent on several posttranslational modifications and the availability of second messengers. Protein Kinase Cs exhibit both pro- and anti-tumorigenic effects making them an interesting target for anti-cancer treatment.

  19. Overtesting and the Downstream Consequences of Overtreatment: Implications of "Preventing Overdiagnosis" for Emergency Medicine. (United States)

    Carpenter, Christopher R; Raja, Ali S; Brown, Michael D


    Overtesting, the downstream consequences of overdiagnosis, and overtreatment of some patients are topics of growing debate within emergency medicine (EM). The "Preventing Overdiagnosis" conference, hosted by The Dartmouth Institute for Health Policy and Clinical Practice, with sponsorship from consumer organizations, medical journals, and academic institutions, is evidence of an expanding interest in this topic. However, EM represents a compellingly unique environment, with increased decision density tied to high stakes for patients and providers with missed or delayed diagnoses in a professional atmosphere that does not tolerate mistakes. This article reviews the relevance of this reductionist paradigm to EM, provides a first-hand synopsis of the first "Preventing Overdiagnosis" conference, and assesses barriers to moving the concept of less test ordering to reality. © 2015 by the Society for Academic Emergency Medicine.

  20. Vegetable oil feeding into modern diesel engines. Effects, regulation methods, limit values; Pflanzenoeleintrag in moderne Dieselmotoren. Auswirkungen, Bestimmungsmethoden, Grenzwerte

    Energy Technology Data Exchange (ETDEWEB)

    Heine, C.; Fischer, T.


    The need for a reliable method for the detection of the amount of fuel in engine oils is nearly as old as the first engine oil specification. An increased amount of conventional fuel in the engine oil can cause several problems up to a mechanical breakdown of the engine. Modern fuels and new concepts in the base oil technology of modern engine oils up to so called 'bio engine oils' are responsible for the intensification of the discussion about of the acceptable amount of fuel in the engine oil. Especially in Germany there is an increasing volume of vegetable oil in the market which is used as an alternative fuel for conventional diesel fuel. Actually we have the first engine manufacturers who offer engines for the use with rape oil as a fuel. Unfortunately, up to now, we don't have a proved European - or DIN standard (only the prestandard DIN V 51605) for vegetable oils as fuel. The DIN prestandard is only for rape oil. But in the field palm-oil, sunflower-oil and several more can be found in the tanks of the engines. Moreover, up to know no official information exists about the allowed amount of vegetable oil in the engine oil. Even of those manufacturers who now offer the engines for the use with rape oil. The main answer of some engine manufacturers sounds like 'We don't allow the use of vegetable oil so there is no need for a limit value'. That is logical - at the first moment. But it is well known that a lot of trucks and power units are fired with vegetable oil. Till today WEARCHECK analysed several thousand used engine oils which where used in diesel engines with vegetable oil as fuel. The presentation gives some examples of rape oil fuel dilution and the influence on the engine and engine oil. Moreover it will give an idea how to determine the vegetable oil in engine oils. At the end the presentation shall initiate a discussion about a recommendation for the max. amount of vegetable oil dilution in engine oils. (orig.)

  1. Industrial Policy Approaches from Theory to Practice in European Union

    Directory of Open Access Journals (Sweden)

    Anca Dachin


    Full Text Available The main debate about industrial policy consists of the attitude regarding the role of state versus market. The admission of possible market failures was the inspiration source for policies in the field of competition strengthening, supply of public goods, overcoming the deficit of capital etc. The general objectives of industrial policy may vary from the absolute role of the market to the market control. The European Community has applied a diversity of policies, differentiated from one period to another, in connection with the competition pressure on the world market and with the European integration stages. The EC had at its beginning a complete faith in the market mechanism, then a period of protectionism followed, as an answer to the oil shock and to the pressure of competition on international markets, especially coming from large American and Japanese companies. During the period 1985-1990, the European Community began to establish an industrial policy to encourage partnership between European companies and to promote cooperation in the field of research and development. In 1990 the European Commission proposed a new coherent concept of market oriented industrial policy, according to the model of neutral policy. Industrial policy is strongly connected to the competition policy. Especially after 1995, there have been signs of worry about the lower competitiveness in terms of productivity growth rate, expenditures for research and innovation capacity compared to USA and Japan. In addition, the European industry must face the competition pressure coming from the emergence of countries, mainly those from South-East Asia. In this context, the key factor which ensures a favorable perspective for the industry is competitiveness. This also implies expected positive effects of EU enlargement. The decision to sustain competitiveness was already taken in Lisbon, where a modern strategy was presented. Its priorities are the creation of a suitable

  2. Industrial Policy Approaches from Theory to Practice in European Union

    Directory of Open Access Journals (Sweden)

    Anca Dachin


    Full Text Available The main debate about industrial policy consists of the attitude regarding the role of state versus market. The admission of possible market failures was the inspiration source for policies in the field of competition strengthening, supply of public goods, overcoming the deficit of capital etc. The general objectives of industrial policy may vary from the absolute role of the market to the market control. The European Community has applied a diversity of policies, differentiated from one period to another, in connection with the competition pressure on the world market and with the European integration stages. The EC had at its beginning a complete faith in the market mechanism, then a period of protectionism followed, as an answer to the oil shock and to the pressure of competition on international markets, especially coming from large American and Japanese companies. During the period 1985-1990, the European Community began to establish an industrial policy to encourage partnership between European companies and to promote cooperation in the field of research and development. In 1990 the European Commission proposed a new coherent concept of market oriented industrial policy, according to the model of neutral policy. Industrial policy is strongly connected to the competition policy. Especially after 1995, there have been signs of worry about the lower competitiveness in terms of productivity growth rate, expenditures for research and innovation capacity compared to USA and Japan. In addition, the European industry must face the competition pressure coming from the emergence of countries, mainly those from South-East Asia. In this context, the key factor which ensures a favorable perspective for the industry is competitiveness. This also implies expected positive effects of EU enlargement. The decision to sustain competitiveness was already taken in Lisbon, where a modern strategy was presented. Its priorities are the creation of a suitable

  3. Downstream and seasonal changes of lithium isotope ratios in the Ganges-Brahmaputra river system (United States)

    Manaka, Takuya; Araoka, Daisuke; Yoshimura, Toshihiro; Hossain, H. M. Zakir; Nishio, Yoshiro; Suzuki, Atsushi; Kawahata, Hodaka


    The Li isotope ratio (δ7Li) is expected to be a useful tracer of silicate weathering in river and groundwater systems, which is an important contributor to the seawater compositional changes that accompany the evolution of the Earth's surface environment. To obtain accurate estimates of continental Li fluxes to the ocean, we determined δ7Li values of dissolved Li in the lower Ganges-Brahmaputra river system in both the dry and rainy seasons, and in deep groundwater in the Bengal basin. Dissolved Li and δ7Li values in the lower reaches of the rivers (0.04-0.66 µmol kg-1 and +19.1‰ to +34.2‰, respectively) were predominantly derived from silicate weathering, as is the case in the upper parts of these rivers. We observed large changes in δ7Li over a distance of more than 1000 km downstream that were due mainly to Rayleigh-type removal of Li from river water. Extremely high Li concentrations (1.15-1.67 µmol kg-1) and low δ7Li values (+5.1‰ to +11.6‰) in groundwater samples indicate congruent isotope leaching and dissolution of silicate minerals in the deep aquifer, where the water residence time is long. In the rainy season, Li concentrations and δ7Li values were lower than in the dry season, owing to the shorter residence time of river water and the substantial input of local subsurface flow through lowland alluvium. These results suggest that accurate estimation of continental Li fluxes to the ocean should take account of downstream and seasonal changes, as well as aquifer depth variations, in δ7Li values.

  4. Dams in the Cadillac Desert: downstream effects in a geomorphic context. (United States)

    Sabo, John L; Bestgen, Kevin; Graf, Will; Sinha, Tushar; Wohl, Ellen E


    This paper was motivated by the 25th anniversary of the publication of Marc Reisner's book, Cadillac Desert: The American West and its Disappearing Water. Dams are ubiquitous on rivers in the United States, and large dams and storage reservoirs are the hallmark of western U.S. riverscapes. The effects of dams on downstream river ecosystems have attracted much attention and are encapsulated in the serial discontinuity concept (SDC). In the SDC, dams create abrupt shifts in continua of downstream changes in physical and biotic properties. In this paper, we develop a framework for understanding how channel geometry and network structure influence how the physical components of habitat and the biota rebound from discontinuities set up by large dams. We apply this framework to data describing the flow regime, temperature, sediment flux, and fish community composition below Garrison Dam on the Missouri River, Glen Canyon Dam on the Colorado River, and Flaming Gorge Dam on the Green River. Sediment flux in dam tailwaters is under strong control by channel geometry. By contrast, dam-related changes in temperature and flow variation are not significantly modulated by channel geometry or tributary inputs if flow volumes are small (Missouri and Colorado River tributaries). Instead, small tributaries provide near-native conditions (flow and temperature variation) and, as such, provide key refuges for biota from novel habitats in mainstem rivers below large dams. Unregulated tributaries that are large relative to their respective mainstem (e.g., Yampa River) provide refuges as well as significant amelioration of flow and temperature effects from upstream dams. Finally, the proportion of native fish increases with distance from dam and exhibits sharp increases near tributary junctions. These results suggest that tributaries-even minor ones in terms of relative discharge-act as key refugia for native species in regulated river networks. Moreover, large, unregulated tributaries

  5. Use of bone scan during initial prostate cancer workup, downstream procedures, and associated Medicare costs. (United States)

    Falchook, Aaron D; Salloum, Ramzi G; Hendrix, Laura H; Chen, Ronald C


    For patients with a high likelihood of having metastatic disease (high-risk prostate cancer), bone scan is the standard, guideline-recommended test to look for bony metastasis. We quantified the use of bone scans and downstream procedures, along with associated costs, in patients with high-risk prostate cancer, and their use in low- and intermediate-risk patients for whom these tests are not recommended. Patients in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database diagnosed with prostate cancer from 2004 to 2007 were included. Prostate specific antigen (PSA), Gleason score, and clinical T stage were used to define D'Amico risk categories. We report use of bone scans from the date of diagnosis to the earlier of treatment or 6 months. In patients who underwent bone scans, we report use of bone-specific x-ray, computed tomography (CT), and magnetic resonance imaging (MRI) scans, and bone biopsy within 3 months after bone scan. Costs were estimated using 2012 Medicare reimbursement rates. In all, 31% and 48% of patients with apparent low- and intermediate-risk prostate cancer underwent a bone scan; of these patients, 21% underwent subsequent x-rays, 7% CT, and 3% MRI scans. Bone biopsies were uncommon. Overall, bone scans and downstream procedures was $11,300,000 for low- and intermediate-risk patients. For patients with apparent high-risk disease, only 62% received a bone scan, of whom 14% were found to have metastasis. There is overuse of bone scans in patients with low- and intermediate-risk prostate cancers, which is unlikely to yield clinically actionable information and results in a potential Medicare waste. However, there is underuse of bone scans in high-risk patients for whom metastasis is likely. Copyright © 2014 Elsevier Inc. All rights reserved.

  6. Simple preparation of plant epidermal tissue for laser microdissection and downstream quantitative proteome and carbohydrate analysis

    Directory of Open Access Journals (Sweden)

    Christian eFalter


    Full Text Available The outwardly directed cell wall and associated plasma membrane of epidermal cells represent the first layers of plant defense against intruding pathogens. Cell wall modifications and the formation of defense structures at sites of attempted pathogen penetration are decisive for plant defense. A precise isolation of these stress-induced structures would allow a specific analysis of regulatory mechanism and cell wall adaption. However, methods for large-scale epidermal tissue preparation from the model plant Arabidopsis thaliana, which would allow proteome and cell wall analysis of complete, laser-microdissected epidermal defense structures, have not been provided. We developed the adhesive tape – liquid cover glass technique for simple leaf epidermis preparation from A. thaliana, which is also applicable on grass leaves. This method is compatible with subsequent staining techniques to visualize stress-related cell wall structures, which were precisely isolated from the epidermal tissue layer by laser microdissection coupled to laser pressure catapulting. We successfully demonstrated that these specific epidermal tissue samples could be used for quantitative downstream proteome and cell wall analysis. The development of the adhesive tape – liquid cover glass technique for simple leaf epidermis preparation and the compatibility to laser microdissection and downstream quantitative analysis opens new possibilities in the precise examination of stress- and pathogen-related cell wall structures in epidermal cells. Because the developed tissue processing is also applicable on A. thaliana, well-established, model pathosystems that include the interaction with powdery mildews can be studied to determine principal regulatory mechanisms in plant-microbe interaction with their potential outreach into crop breeding.

  7. A computational fluid dynamics modeling study of guide walls for downstream fish passage (United States)

    Mulligan, Kevin; Towler, Brett; Haro, Alexander J.; Ahlfeld, David P.


    A partial-depth, impermeable guidance structure (or guide wall) for downstream fish passage is typically constructed as a series of panels attached to a floating boom and anchored across a water body (e.g. river channel, reservoir, or power canal). The downstream terminus of the wall is generally located nearby to a fish bypass structure. If guidance is successful, the fish will avoid entrainment in a dangerous intake structure (i.e. turbine intakes) while passing from the headpond to the tailwater of a hydroelectric facility through a safer passage route (i.e. the bypass). The goal of this study is to determine the combination of guide wall design parameters that will most likely increase the chance of surface-oriented fish being successfully guided to the bypass. To evaluate the flow field immediately upstream of a guide wall, a parameterized computational fluid dynamics model of an idealized power canal was constructed in © ANSYS Fluent v 14.5 (ANSYS Inc., 2012). The design parameters investigated were the angle and depth of the guide wall and the average approach velocity in the power canal. Results call attention to the importance of the downward to sweeping flow ratio and demonstrate how a change in guide wall depth and angle can affect this important hydraulic cue to out-migrating fish. The key findings indicate that a guide wall set at a small angle (15° is the minimum in this study) and deep enough such that sweeping flow dominant conditions prevail within the expected vertical distribution of fish approaching the structure will produce hydraulic conditions that are more likely to result in effective passage.

  8. Modelling of the impact of biofouling on hydrodynamics downstream of a tidal turbine (United States)

    Bennis, A. C.; Rivier, A.; Dauvin, J. C.


    Biological organisms, like barnacles, mussels or bryozoans, colonize rapidly an immersed surface and could form a thickness until several centimeters on it. This biofouling could modify hydrodynamics around tidal turbine by increasing drag and hence resistance and could be detrimental to the performance of turbine (e.g. Orme et al., 2001; Khor and Xiao, 2011). Our work focuses on modifications of vortices downstream of a tidal turbine due to biofouling using CFD. Fixed biological organisms are solved explicitly by the model and are considered by modifying the blade profile. Firstly an airfoil colonized by barnacles is modelled for various fouling height and spacing and results are compared to experimental and simulated data (Orme et al., 2001; Khor and Xiao, 2011) in order to assess the capacity of the model to reproduce the flow around a blade with biofouling. Then a Darrieus vertical axis tidal turbine is modelled using a dynamic mesh. Configuration with smooth clean blades is assessed by comparison with experiments and simulations made by Roa (2011) and Bossard (2012). Biological organisms with various heights, spacing and shapes are fixed on blades and wakes downstream of clean and colonized tidal turbine are compared. Vorticity fields around the tidal turbine are clearly modified when blades are colonized. Samples will be taken from location where farms are planned to be built (Alderney Race/Raz Blanchard) to characterize more precisely the characteristics of species which are liable to fix on tidal turbine.Reference:Bossard (2012). Doctoral dissertation, Université de Grenoble.Khor & Xiao. (2011). Ocean Eng, 38(10), 1065-1079. Orme et al. (2001). Marine Renewable Energy Conference, Newcastle.Roa (2011).Doctoral dissertation, Université de Grenoble.

  9. The Maternal Obesity Management (MOM) Trial Protocol: a lifestyle intervention during pregnancy to minimize downstream obesity. (United States)

    Adamo, Kristi B; Ferraro, Zachary M; Goldfield, Gary; Keely, Erin; Stacey, Dawn; Hadjiyannakis, Stasia; Jean-Philippe, Sonia; Walker, Mark; Barrowman, Nicholas J


    Maternal obesity and/or high gestational weight gain (GWG) are associated with downstream child obesity. Pregnancy represents a critical period for prevention as women are highly motivated and more receptive to behavior change. This pilot study was developed to test the feasibility of intervening with the mother, specifically keeping her GWG within the Institute of Medicine (IOM) limits, with the intended target of preventing obesity in her child downstream. We are testing the practicality of delivering a structured physical activity and nutrition intervention to pregnant women during gestation and then following mom and baby to 24 months of age. This study is a two-arm, parallel group, randomized controlled trial being conducted in Ottawa. Pregnant women, with pregravid BMI >18.5, between 12 and 20 weeks gestation are randomized to one of two groups: intervention (n=30) who receive the MOM trial Handbook (guide to healthy gestation) plus a structured physical activity and nutrition program, or a standard clinical care control group (n=30). The intervention lasts 25-28 weeks (6 months) depending on anticipated delivery date, with follow-up assessment on mother and child at 3, 6, 12 and 24 months post-delivery. Pregnancy, a critical time of growth, development and physiological change, provides an opportunity for early lifestyle intervention. The goal of identifying an effective lifestyle program for the gestational period that leads to healthy fetal development and subsequently normal weight offspring, less likely to develop obesity and its co-morbidities, is unique and could possibly attenuate the inter-generational cycle of obesity. Copyright © 2013 Elsevier Inc. All rights reserved.

  10. Use of Bone Scan During Initial Prostate Cancer Workup, Downstream Procedures, and Associated Medicare Costs

    Energy Technology Data Exchange (ETDEWEB)

    Falchook, Aaron D. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Salloum, Ramzi G. [Department of Health Services Policy and Management, University of South Carolina, Columbia, South Carolina (United States); Hendrix, Laura H. [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Chen, Ronald C., E-mail: [Department of Radiation Oncology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States); Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina (United States)


    Purpose: For patients with a high likelihood of having metastatic disease (high-risk prostate cancer), bone scan is the standard, guideline-recommended test to look for bony metastasis. We quantified the use of bone scans and downstream procedures, along with associated costs, in patients with high-risk prostate cancer, and their use in low- and intermediate-risk patients for whom these tests are not recommended. Methods and Materials: Patients in the Surveillance, Epidemiology, and End Results (SEER)-Medicare database diagnosed with prostate cancer from 2004 to 2007 were included. Prostate specific antigen (PSA), Gleason score, and clinical T stage were used to define D'Amico risk categories. We report use of bone scans from the date of diagnosis to the earlier of treatment or 6 months. In patients who underwent bone scans, we report use of bone-specific x-ray, computed tomography (CT), and magnetic resonance imaging (MRI) scans, and bone biopsy within 3 months after bone scan. Costs were estimated using 2012 Medicare reimbursement rates. Results: In all, 31% and 48% of patients with apparent low- and intermediate-risk prostate cancer underwent a bone scan; of these patients, 21% underwent subsequent x-rays, 7% CT, and 3% MRI scans. Bone biopsies were uncommon. Overall, <1% of low- and intermediate-risk patients were found to have metastatic disease. The annual estimated Medicare cost for bone scans and downstream procedures was $11,300,000 for low- and intermediate-risk patients. For patients with apparent high-risk disease, only 62% received a bone scan, of whom 14% were found to have metastasis. Conclusions: There is overuse of bone scans in patients with low- and intermediate-risk prostate cancers, which is unlikely to yield clinically actionable information and results in a potential Medicare waste. However, there is underuse of bone scans in high-risk patients for whom metastasis is likely.

  11. Planned flooding and Colorado River riparian trade-offs downstream from Glen Canyon Dam, Arizona (United States)

    Stevens, Lawrence E.; Ayers, T.J.; Bennett, J.B.; Christensen, K.; Kearsley, M.J.C.; Meretsky, V.J.; Phillips, A. M.; Parnell, R.A.; Spence, J.; Sogge, M.K.; Springer, A.E.; Wegner, D.L.


    Regulated river restoration through planned flooding involves trade-offs between aquatic and terrestrial components, between relict pre-dam and novel post-dam resources and processes, and between management of individual resources and ecosystem characteristics. We review the terrestrial (wetland and riparian) impacts of a 1274 m3/s test flood conducted by the U.S. Bureau of Reclamation in March/April 1996, which was designed to improve understanding of sediment transport and management downstream from Glen Canyon Dam in the Colorado River ecosystem. The test flood successfully restored sandbars throughout the river corridor and was timed to prevent direct impacts to species of concern. A total of 1275 endangered Kanab ambersnail (Oxyloma haydeni kanabensis) were translocated above the flood zone at Vaseys Paradise spring, and an estimated 10.7% of the total snail habitat and 7.7% of the total snail population were lost to the flood. The test flood scoured channel margin wetlands, including potential foraging habitats of endangered Southwestern Willow Flycatcher (Empidonax traillii extimus). It also buried ground-covering riparian vegetation under >1 m of fine sand but only slightly altered woody sandbar vegetation and some return-current channel marshes. Pre-flood control efforts and appropriate flood timing limited recruitment of four common nonnative perennial plant species. Slight impacts on ethnobotanical resources were detected >430 km downstream, but those plant assemblages recovered rapidly. Careful design of planned flood hydrograph shape and seasonal timing is required to mitigate terrestrial impacts during efforts to restore essential fluvial geomorphic and aquatic habitats in regulated river ecosystems.

  12. Assessing the Downstream Impact of the Integrated Use of Socioeconomic and Remote Sensing Data (United States)

    Chen, R. S.; Downs, R. R.; Schumacher, J.


    The interdisciplinary use of data from multiple disciplines to address both research and applied problems has received increasing attention in the sciences, but understanding remains limited on the specific modalities of data use and their impact not only in enabling new research insights but also in facilitating the application of research to societal problems. In our previous work, we used citation analysis to investigate the use of data from the NASA Socioeconomic Data and Applications Center (SEDAC) and identify the extent of interdisciplinary use, based on the subject classifications of citing journals. We also proposed and tested a taxonomy of data integration and use on a selection of peer-reviewed scientific articles that cited both remote sensing data and socioeconomic data from SEDAC. We extend both of these analyses here. We analyze the interdisciplinary use of SEDAC data over a seven-year period including the types and topical areas of application observed. We also explore the degree to which different types of data integration and use are leading to further "downstream" research and applications, and if objective measures can be developed using bibliometric methods to quantify downstream use and impact in meaningful ways. These methods include both traditional citation analysis and searches of the informal literature and online resources. Better understanding of how disparate data and information has been utilized to address new interdisciplinary problems will help the data user and provider communities improve the effectiveness and efficiency of their efforts. It should also provide justification for further investments in linking different data resources and networks across scientific fields, in methods of interdisciplinary data integration, and in application of integrated data to societal problems.

  13. Numerical Simulation of Missouri River Bed Evolution Downstream of Gavins Point Dam (United States)

    Sulaiman, Z. A.; Blum, M. D.; Lephart, G.; Viparelli, E.


    The Missouri River originates in the Rocky Mountains in western Montana and joins the Mississippi River near Saint Louis, Missouri. In the 1900s dam construction and river engineering works, such as river alignment, narrowing and bank protections were performed in the Missouri River basin to control the flood flows, ensure navigation and use the water for agricultural, industrial and municipal needs, for the production of hydroelectric power generation and for recreation. These projects altered the flow and the sediment transport regimes in the river and the exchange of sediment between the river and the adjoining floodplain. Here we focus on the long term effect of dam construction and channel narrowing on the 1200 km long reach of the Missouri River between Gavins Point Dam, Nebraska and South Dakota, and the confluence with the Mississippi River. Field observations show that two downstream migrating waves of channel bed degradation formed in this reach in response to the changes in flow regime, sediment load and channel geometry. We implemented a one dimensional morphodynamic model for large, low slope sand bed rivers, we validated the model at field scale by comparing the numerical results with the available field data and we use the model to 1) predict the magnitude and the migration rate of the waves of degradation at engineering time scales ( 150 years into the future), 2) quantify the changes in the sand load delivered to the Mississippi River, where field observations at Thebes, i.e. downstream of Saint Louis, suggest a decline in the mean annual sand load in the past 50 years, and 3) identify the role of the main tributaries - Little Sioux River, Platte River and Kansas River - on the wave migration speed and the annual sand load in the Missouri River main channel.

  14. Targeting the cis-dimerization of LINGO-1 with low MW compounds affects its downstream signalling. (United States)

    Cobret, L; De Tauzia, M L; Ferent, J; Traiffort, E; Hénaoui, I; Godin, F; Kellenberger, E; Rognan, D; Pantel, J; Bénédetti, H; Morisset-Lopez, S


    The transmembrane protein LINGO-1 is a negative regulator in the nervous system mainly affecting axonal regeneration, neuronal survival, oligodendrocyte differentiation and myelination. However, the molecular mechanisms regulating its functions are poorly understood. In the present study, we investigated the formation and the role of LINGO-1 cis-dimers in the regulation of its biological activity. LINGO-1 homodimers were identified in both HEK293 and SH-SY5Y cells using co-immunoprecipitation experiments and BRET saturation analysis. We performed a hypothesis-driven screen for identification of small-molecule protein-protein interaction modulators of LINGO-1 using a BRET-based assay, adapted for screening. The compound identified was further assessed for effects on LINGO-1 downstream signalling pathways using Western blotting analysis and AlphaScreen technology. LINGO-1 was present as homodimers in primary neuronal cultures. LINGO-1 interacted homotypically in cis-orientation and LINGO-1 cis-dimers were formed early during LINGO-1 biosynthesis. A BRET-based assay allowed us to identify phenoxybenzamine as the first conformational modulator of LINGO-1 dimers. In HEK-293 cells, phenoxybenzamine was a positive modulator of LINGO-1 function, increasing the LINGO-1-mediated inhibition of EGF receptor signalling and Erk phosphorylation. Our data suggest that LINGO-1 forms constitutive cis-dimers at the plasma membrane and that low MW compounds affecting the conformational state of these dimers can regulate LINGO-1 downstream signalling pathways. We propose that targeting the LINGO-1 dimerization interface opens a new pharmacological approach to the modulation of its function and provides a new strategy for drug discovery. © 2014 The British Pharmacological Society.

  15. Crude oil burning mechanisms

    DEFF Research Database (Denmark)

    van Gelderen, Laurens; Malmquist, L.M.V.; Jomaas, Grunde


    In order to improve predictions for the burning efficiency and the residue composition of in-situ burning of crude oil, the burning mechanism of crude oil was studied in relation to the composition of its hydrocarbon mixture, before, during and after the burning. The surface temperature, flame...... height, mass loss rate and residues of three hydrocarbon liquids (n-octane, dodecane and hexadecane), two crude oils (DUC and REBCO) and one hydrocarbon liquid mixture of the aforementioned hydrocarbon liquids were studied using the Crude Oil Flammability Apparatus. The experimental results were compared...... on the highest achievable oil slick temperature. Based on this mechanism, predictions can then be made depending on the hydrocarbon composition of the fuel and the measured surface temperature....

  16. Intraventricular Silicone Oil (United States)

    Mathis, Stéphane; Boissonnot, Michèle; Tasu, Jean-Pierre; Simonet, Charles; Ciron, Jonathan; Neau, Jean-Philippe


    Abstract Intracranial silicone oil is a rare complication of intraocular endotamponade with silicone oil. We describe a case of intraventricular silicone oil fortuitously observed 38 months after an intraocular tamponade for a complicated retinal detachment in an 82 year-old woman admitted in the Department of Neurology for a stroke. We confirm the migration of silicone oil along the optic nerve. We discuss this rare entity with a review of the few other cases reported in the medical literature. Intraventricular migration of silicone oil after intraocular endotamponade is usually asymptomatic but have to be known of the neurologists and the radiologists because of its differential diagnosis that are intraventricular hemorrhage and tumor. PMID:26735537

  17. Approach of fuzzy logic in the preliminary risk analysis of the upstream and downstream lines of an offshore petroleum production unit

    Energy Technology Data Exchange (ETDEWEB)

    Garcia, Claudio B. [PETROBRAS Transporte S.A. (TRANSPETRO), Rio de Janeiro, RJ (Brazil); Pinho, Edson [Universidade Federal Rural do Rio de Janeiro (UFRRJ), Seropedica, RJ (Brazil); Maia Neto, Luiz


    This work consists of the application of a model of qualitative risk assessment based in fuzzy logic for the judgment of criticality of the scenarios of accident identified through the technique of preliminary hazard analysis in the upstream and downstream of an offshore oil production unit already in operation. The model based on fuzzy logic acts as substitute to the traditional Risks Matrix that uses subjective concepts for the categories of expected severity and frequency of the accidents. The structure of the employed model consists of 7 input variables, an internal variable and an output variable, all linked in accordance with the modules of analysis for each type of accident. The developed base of knowledge, that complete the expert system consists of membership functions developed for each one of the variables and a set of 219 distributed inference rules in the 7 different modules. The developed knowledge base, which incorporates the mechanisms of logical reasoning of specialists, assists and guides, with efficiency, the teams that carry through the preliminary hazard analyses with the use of a computer program having previously inserted routines. The employed model incorporates in the knowledge base of the program the existing concepts in the categories of frequency and severity, under the form of membership functions of the linguistic variable and the set of rules. With this, scales subdivided in ranges, defined on the basis of the existing direction present in the risks matrices are used to define the actions to be taken for the analyzed accident scenarios. (author)

  18. The European XFEL Project

    CERN Document Server

    Trunk, U


    The European XFEL project is a 4th generation photon source to be built in Hamburg. Electron bunches, accelerated to 17.5GeV by the XFEL linac, are distributed to three long SASE undulators. There photon pulses with full lateral coherence and wavelengths between 0.1nm and 4.9nm (12.4 keV and 0.8 keV) are generated for three beamlines. It will deliver around 1012photons within each 100 fs pulse, reaching a peak brilliance of 1033photonss−1mm−2mrad−2(0.1%BW)−1. Thus it will offer unprecedented possibilities in photon science research including nano-object imaging and studies (e.g. by coherent X-ray scattering) and ultra fast dynamic analysis of plasma and chemical reactions (e.g. by X-ray photo correlation spectroscopy). The detector requirements for such studies are extremely challenging: position sensitive area detectors have to provide a dynamic range of ≥ 104, with single-photon sensitivity, while withstanding radiation doses up to 1GGy (TID). Furthermore the detectors have to record data from tra...

  19. Proceedings of the 3. international symposium on applied microbiology and molecular biology in oil systems: ISMOS 3

    Energy Technology Data Exchange (ETDEWEB)

    Rooijen, Gijs van; Caffrey, Sean M. [Genome Alberta (Canada); Lund Skovhus, Torben [DTI Oil and Gas (Denmark); Whitby, Corinne [University of Essex (United Kingdom)


    The 3rd international symposium on applied microbiology and molecular biology in oil systems was held in Calgary, Alberta, Canada, from June 13th to June 15th, 2011. This conference, organized by ISMOS TSC, gathered experts to discuss the application of microbial and molecular biology in the hydrocarbon sector. The conference was attended by key players from the oil and gas industry and provided them with the opportunity to learn about some of the latest technologies in areas such as the application of molecular microbiological methods for oil field systems, biodegradation of hydrocarbons in oil production, biofuels and downstream petroleum microbiology and challenges in biofuels and oil sands developments, and to network with their peers and share their expertise. 17 of the 31 papers presented during this conference have been catalogued separately for inclusion in this database.

  20. Effects of a Liberalized European Gas Market

    Energy Technology Data Exchange (ETDEWEB)

    Austvik, Ole Gunnar


    , firms, these must be made to behave in a way that improves efficiency. In fact, an increase in the number of actors in such markets, per se, may increase cost, and, thus, represent a waste of resources. Usually, but not necessarily, state owned firms are privatised (even though the government may hold a significant share, or control over, the ownership), the operation of vertically integrated services are separated (''unbundled''), competition is established when possible and regulation introduced when necessary (when competition does not work). In the case of natural gas, the U.S. and Canada liberalized their markets in the mid 1980s. Later, gas markets in the U.K., and then Australia and New Zealand, followed. Now, in the European natural gas industry, both market growth and infrastructural developments, as well as political decision making, forcing competition on to firms, is now creating a more competitive environment. In order to analyze these issues in relation to Norway as a major natural gas exporter we have studied the development of EU energy policies, price effects of liberalism, energy taxation, the economics of non-renewable (exhaustible) resources and regulatory economics as well as foreign policy issues concerning security-of-supply issues. The complexity and interdisciplinary insights needed to analyze the European gas market makes it even more complex than analyses of the global oil market. In the European gas market, the problem of choosing the right in-depth level and correct parameters and discipline to apply, becomes particularly apparent and challenging. For most analysts and policy makers, it seems to be an overwhelming task to describe exactly how a liberalized European gas market works, how it should be organized and will develop. In this analysis of the political economy of European gas, we will nevertheless try to shed some light on the causes and effects of what may happen.