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  1. Enquete sur les aspects toxicologiques de la phytotherapie utilisee par un herboriste à Fes, Maroc

    Science.gov (United States)

    Zeggwagh, Ali Amine; Lahlou, Younes; Bousliman, Yassir

    2013-01-01

    Introduction Dans le but d'étudier l'aspect toxicologique des plantes médicinales utilisées en médecine traditionnelle, une étude ethnobotanique a été réalisée à la ville de Fès au centre du Maroc. Méthodes Ont été inclus dans l'étude tous les patients ayant bénéficié d'une prescription par l'herboriste de plantes à visée thérapeutique. La discussion de nos résultats s'est faite sur la base d'une revue de la littérature avec identification des principales plantes toxiques utilisées en phytothérapie au Maroc. L'approche bibliographique a permis de compléter les informations. Résultats L'âge moyen des patients traités par des plantes (38 femmes, 32 hommes) était de 35 ± 18 ans. L'enquête ethnobotanique à révélé que la majorité des plantes médicinales étaient utilisées contre les affections urinaires (21%), suivi des maladies de l'appareil digestif (19.6%) et des maladies rhumatologiques (18.2%). Le nombre de plantes prescrits par l'herboriste a été de 53 dont 5 sont potentiellement toxiques. L'identification taxonomique des plantes prescrites a recensé 30 familles dont les plus représentées sont les Lamiaceae (23.33%), les Apiaceae (13,33%) et les Asteraceae (10%). La prescription des plantes considérées comme toxiques a concerné 7,1% des consultants traités par les plantes médicinales. Aucune complication inhérente aux plantes prescrites n'a été déplorée. Conclusion Malgré les résultats encourageants de notre enquête sur le compte de la phytothérapie, la pratique de la phytothérapie est laissée à la vulgarisation et à l'oubli scientifique, législatif et universitaire. PMID:23734270

  2. Enquete sur les aspects toxicologiques de la phytotherapie utilisee par un herboriste ? Fes, Maroc

    OpenAIRE

    Zeggwagh, Ali Amine; Lahlou, Younes; Bousliman, Yassir

    2013-01-01

    Introduction Dans le but d'?tudier l'aspect toxicologique des plantes m?dicinales utilis?es en m?decine traditionnelle, une ?tude ethnobotanique a ?t? r?alis?e ? la ville de F?s au centre du Maroc. M?thodes Ont ?t? inclus dans l'?tude tous les patients ayant b?n?fici? d'une prescription par l'herboriste de plantes ? vis?e th?rapeutique. La discussion de nos r?sultats s'est faite sur la base d'une revue de la litt?rature avec identification des principales plantes toxiques utilis?es en phytoth...

  3. Analytical procedures used by the uranium - radon - radium geochemistry group; Methodes d'analyses utilisees par la section de geochimie uranium, radon, radium

    Energy Technology Data Exchange (ETDEWEB)

    Berthollet, P. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    The analytical methods described are applied to the geochemical prospecting of uranium. The nature of the material under investigation, which may be soil, alluvium, rock, plant or water, and the particular requirements of geochemical exploration, have prompted us to adjust the widely used conventional methods to the demands of large scale operation, without lowering their standards of accuracy and reliability. These procedures are explained in great detail. Though most of this technical information may appear superfluous to the chemical engineer well versed in trace element determination, it will, however, serve a useful purpose both with the operator in charge of routine testing and with the chemist called upon to interpret results. (author) [French] Les methodes d'analyses decrites sont utilisees pour la prospection geochimique de l'uranium. La nature des materiaux: sols, alluvions, roches, vegetaux, eaux, et les exigences propres a la prospection geochimique, nous ont conduit a adapter des methodes classique couramment utilisees pour les rendre aptes a etre executees en grande serie, sans abandonner leurs qualites de precision et de fidelite. Ces methodes sont presentees avec un maximum de details operatoires qui paraitront superflus aux chimistes habitues aux dosages de traces, mais seront utiles aussi bien aux manipulateurs charges des analyses qu'aux geochimistes appeles a exploiter les resultats. (auteur)

  4. The ETE spherical Tokamak project

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Gerson Otto; Andrade, Maria Celia Ramos de; Barbosa, Luis Filipe Wiltgen [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Lab. Associado de Plasma] [and others]. E-mail: ludwig@plasma.inpe.br

    1999-07-01

    This paper describes the general characteristics of spherical tokamaks, with a brief overview of work in the area of spherical torus already performed or in progress at several institutions. The paper presents also the historical development of the ETE (Spherical Tokamak Experiment) project, its research program, technical characteristics and status of construction in September, 1998 at the Associated plasma Laboratory (LAP) of the National Institute for Space Research (INPE) in Brazil. (author)

  5. Vogtle Electric Generating Plant ETE Analysis Review

    Energy Technology Data Exchange (ETDEWEB)

    Diediker, Nona H.; Jones, Joe A.

    2006-12-09

    Under contract with the Nuclear Regulatory Commission (NRC), staff from Pacific Northwest National Laboratory (PNNL) and Sandia National Laboratory (SNL)-Albuquerque reviewed the evacuation time estimate (ETE) analysis dated April 2006 prepared by IEM for the Vogtle Electric Generating Plant (VEGP). The ETE analysis was reviewed for consistency with federal regulations using the NRC guidelines in Review Standard (RS)-002, Supplement 2 and Appendix 4 to NUREG-0654, and NUREG/CR-4831. Additional sources of information referenced in the analysis and used in the review included NUREG/CR-6863 and NUREG/CR-6864. The PNNL report includes general comments, data needs or clarifications, and requests for additional information (RAI) resulting from review of the ETE analysis.

  6. Fabrication et caracterisation de nanocristaux de silicium localises, realises par gravure electrochimique pour des applications nanoelectroniques

    Science.gov (United States)

    Ayari-Kanoun, Asma

    Ce travail de these porte sur le developpement d'une nouvelle approche pour la localisation et l'organisation de nanocristaux de silicium realises par gravure electrochimique. Cette derniere represente une technique simple et peu couteuse par rapport aux autres techniques couramment utilisees pour la fabrication de nanocristaux de silicium. L'idee de ce travail a ete d'etudier la nanostructuration de minces couches de nitrure de silicium, d'environ 30 nm d'epaisseur pour permettre par la suite un arrangement periodique des nanocristaux de silicium. Cette pre-structuration est obtenue de facon artificielle en imposant un motif periodique via une technique de lithographie par faisceau d'electrons combinee avec une gravure plasma. Une optimisation des conditions de lithographie et de gravure plasma ont permis d'obtenir des reseaux de trous de 30 nm de diametre debouchant sur le silicium avec un bon controle de leur morphologie (taille, profondeur et forme). En ajustant les conditions de gravure electrochimique (concentration d'acide, temps de gravure et densite de courant), nous avons obtenu des reseaux -2D ordonnes de nanocristaux de silicium de 10 nm de diametre a travers ces masques de nanotrous avec le controle parfait de leur localisation, la distance entre les nanocristaux et leur orientation cristalline. Des etudes electriques preliminaires sur ces nanocristaux ont permis de mettre en evidence des effets de chargement. Ces resultats tres prometteurs confirment l'interet des nanocristaux de silicium realises par gravure electrochimique dans le futur pour la fabrication a grande echelle de dispositifs nanoelectroniques. Mots-cles : localisation, organisation, nanocristaux de silicium, gravure electrochimique, lithographie electronique, gravure plasma, nitrure de silicium.

  7. The ETE spherical Tokamak project. IAEA report

    Energy Technology Data Exchange (ETDEWEB)

    Ludwig, Gerson Otto; Del Bosco, E.; Berni, L.A.; Ferreira, J.G.; Oliveira, R.M.; Andrade, M.C.R.; Shibata, C.S.; Barroso, J.J.; Castro, P.J.; Patire Junior, H. [Instituto Nacional de Pesquisas Espaciais (INPE), Sao Jose dos Campos, SP (Brazil). Lab. Associado de Plasma]. E-mail: ludwig@plasma.inpe.br

    2002-07-01

    This paper describes the general characteristics of spherical tokamaks, or spherical tori, with a brief overview of work in this area already performed or in progress at several institutions worldwide. The paper presents also the historical development of the ETE (Spherical Tokamak Experiment) project, its research program, technical characteristics and operating conditions as of October, 2002 at the Associated Plasma Laboratory (LAP) of the National Space Research Institute (INPE) in Brazil. (author)

  8. Modelisation numerique et validation experimentale d'un systeme de protection contre le givre par elements piezoelectriques

    Science.gov (United States)

    Harvey, Derek

    Le degivrage au moyen d'actuateurs piezoelectriques est considere comme une avenue prometteuse pour le developpement de systemes a faible consommation d'energie applicables aux helicopteres legers. Ce type de systeme excite des frequences de resonances d'une structure pour produire des deformations suffisantes pour rompre l'adherence de la glace. Par contre, la conception de tel systeme demeure generalement mal comprise. Ce projet de maitrise etudie l'utilisation de methodes numeriques pour assister la conception des systemes de protection contre le givre a base d'elements piezoelectriques. La methodologie retenue pour ce projet a ete de modeliser differentes structures simples et de simuler l'excitation harmonique des frequences de resonance au moyen d'actuateurs piezoelectriques. Le calcul des frequences de resonances ainsi que la simulation de leur excitation a ensuite ete validee a l'aide de montages experimentaux. La procedure a ete realisee pour une poutre en porte-a-faux et pour une plaque plane a l'aide du logiciel de calcul par elements finis, Abaqus. De plus, le modele de la plaque plane a ete utilise afin de realiser une etude parametrique portant sur le positionnement des actuateurs, l'effet de la rigidite ainsi que de l'epaisseur de la plaque. Finalement, la plaque plane a ete degivree en chambre climatique. Des cas de degivrage ont ete simules numeriquement afin d'etudier la possibilite d'utiliser un critere base sur la deformation pour predire le succes du systeme. La validation experimentale a confirme la capacite du logiciel a calculer precisement a la fois les frequences et les modes de resonance d'une structure et a simuler leur excitation par des actuateurs piezoelectriques. L'etude revele que la definition de l'amortissement dans le modele numerique est essentiel pour l'obtention de resultats precis. Les resultats de l'etude parametrique ont demontre l'importance de minimiser l'epaisseur et la rigidite afin de reduire la valeur des frequences

  9. Cartographie des especes de feuilles vegetales utilisees comme ...

    African Journals Online (AJOL)

    Les feuilles de Thaumatococcus daniellii de Musa paradisiaca et Musa acuminata sont les plus utilisées, respectivement par 58,86, 28,47 et ; 5.69 % des enquêtées, notamment au Sud, à l'Ouest, au Centre et l'Est du pays. Les feuilles de Tectona grandis, de Cola cordifolia, de Thalia geniculata, de Ficus platyphylla et de ...

  10. Optimisation des trajectoires verticales par la methode de la recherche de l'harmonie =

    Science.gov (United States)

    Ruby, Margaux

    utilisee toutes les combinaisons possibles. Cette recherche exhaustive nous a fourni l'optimal global; ainsi, la solution de notre algorithme doit se rapprocher le plus possible de la recherche exhaustive afin de prouver qu'il donne des resultats proche de l'optimal global. Une seconde comparaison a ete effectuee entre les resultats fournis par l'algorithme et ceux du Flight Management System (FMS) qui est un systeme d'avionique situe dans le cockpit de l'avion fournissant la route a suivre afin d'optimiser la trajectoire. Le but est de prouver que l'algorithme de la recherche de l'harmonie donne de meilleurs resultats que l'algorithme implemente dans le FMS.

  11. Measurement of a neutral particle flux by a thermal method using the junction temperature effect; Mesure d'un flux de particules neutres par une methode thermique mettant a contribution l'effet de temperature des jonctions

    Energy Technology Data Exchange (ETDEWEB)

    Caron, Anthime [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Services Scientifiques

    1966-07-01

    Among all the methods suitable for measuring neutral particle fluxes obtained by proton charge exchange in an organic gas, the thermal method has been chosen. The energy imparted by the neutral particles to the target in the form of heat leads to the latter temperature increasing; this temperature is usually followed with a thermocouple. In order to increase the sensitivity and the elegance of the apparatus the thermocouple has been replaced by a junction whose characteristics are known to vary with temperature. A calibration is carried out using a beam of charged particles. The response obtained is linear. Measurements have been made with a power of up to 1 mW; the accuracy increases with the energy provided; for 4 joules an accuracy of 10 per cent is obtained. The apparatus may be improved in particular by extending the measurement range towards low power values, and by increasing the accuracy. (author) [French] Parmi toutes les methodes utilisees pour la mesure d'un flux de particules neutres, obtenues par echange de charge de protons dans un gaz organique, nous avons choisi la methode thermique. L'energie cedee par les particules neutres a la cible sous forme de chaleur provoque une elevation de temperature de celle-ci; cette temperature est habituellement reperee par thermocouple. Pour accroitre la sensibilite et la finesse de l'appareillage, nous avons substitue au thermocouple une jonction dont on sait que les caracteristiques varient avec la temperature. Un etalonnage est realise par un faisceau de particules chargees. La reponse obtenue est lineaire. Des puissances de l'ordre du mW ont ete mesurees; la precision croit avec l'energie apportee; elle est de 10 pour cent quand celle-ci est de 4 joules. L'appareillage peut etre notablement perfectionne, pour reculer la gamme des mesures vers les basses puissances et accroitre la precision. (auteur)

  12. Controle sismique d'un batiment en acier de 1 etage par amortisseurs elastomeres et contreventements en Chevron

    Science.gov (United States)

    Girard, Olivier

    reduire grandement l'amplification dynamique essuyee lors d'un seisme du au contenu frequentiel particulier des secousses sismiques. Toutefois, la reduction de la rigidite globale a pour consequence d'augmenter grandement les deplacements de fonctionnement de la structure, ce phenomene etant mitige par les proprietes amortissantes de l'elastomere utilise. Le SRFS propose a ete etudie dans le cadre de la presente maitrise. Les objectifs de l'etude consistent a demontrer l'efficacite et la faisabilite du systeme propose ainsi que de developper une methode de dimensionnement efficace et securitaire pour ce genre de systeme. Afin de faciliter l'obtention des objectifs, l'approche qui a ete utilisee est l'etude comparative d'un meme batiment dimensionne selon deux principes. Le premier est le dimensionnement a la capacite. Le second est un dimensionnement employant le systeme propose. La presente etude a ete scindee en quatre parties distinctes. La premiere est l'etude du materiel elastomere afin de determiner les proprietes utiles lors d'un dimensionnement. La seconde est le dimensionnement et l'etude en laboratoire du comportement d'un cadre contrevente selon un principe de dimensionnement a la capacite. La troisieme partie est le dimensionnement et l'etude en laboratoire du comportement d'un cadre contrevente integrant des amortisseurs elastomeres. La quatrieme et derniere partie est l'etude comparative des performances sismiques d'un batiment qui emploie des cadres amortis avec des amortisseurs elastomeres avec les performances d'un batiment qui emploie un SRFS par contreventements classiques. A la suite des differentes analyses, il a ete possible de conclure sur les performances du systeme propose employant des amortisseurs elastomeres. Le systeme possede un excellent comportement quant aux sollicitations sismiques. Le controle des efforts sismiques est du meme ordre qu'un SRFS par contreventements de ductilite moderee (reduction des efforts elastiques par un facteur de 3

  13. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  14. Automation on computer of the partial area method in the analysis of resonances induced by 'S' neutrons 2. with an interference term and extension of the method to the treatment of multi resonances (1963); Automatisation sur ordinateur de la methode des aires partielles dans l'analyse des resonances induites par les neutrons ''S''. 2, avec terme d'interference et extension de la methode au traitement des multiresonances (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, G.; Corge, C.R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    This report deals with the numerical analysis on an I.B.M. 7090 computer of transmission resonances induced by 's' wave neutrons in time of flight experiments. The analysis method used is the partial area one. In this second part the interference term is taken into account. Modifications have been made in the programs and subroutines described in the first part, to determine the resonant transmissions from experimental raw data, and the relating partial areas. Also programs and subroutines are thoroughly described, which estimate the resonance parameters. The field of the partial area method has been extended to cover the case where several resonances have to be treated simultaneously, provided they do not interfere. (authors) [French] Le pretent rapport a pour objet l'analyse numerique sur ordinateur I.B.M. 7090 des resonances dues aux neutrons ''s'' dans les experiences de transmission par temps de vol, la methode d'analyse utilisee etant la methode dea aires partielles. Dans cette deuxieme partie il a ete tenu compte du terme d'interference. On y trouvera une description des amenagements apportes aux programmes et sous-programmes decrits dans la premiere partie pour determiner les transmissions interfero-resonnantes a partir des donnees experimentales brutes et les aires partielles afferentes. Sont egalement decrits les programmes et sous-programmes necessaires au calcul des parametres caracteristiques des resonances. Le domaine d'application de la methode a ete etendu au traitement simultane de plusieurs resonances groupees n'interferant pas entre elles. (auteurs)

  15. Aikido cīņas mākslas etiķete un filozofija

    OpenAIRE

    Suhova, Jeļena

    2013-01-01

    Bakalaura darbs veltīts Japānas cīņu mākslas aikido filozofijas un etiķetes izpētei, kas nosaka pareizos veidus, kā apgūt aikido. Aikido cīņas māksla ar savu nosaukumu kļuva pazīstama salīdzinoši nesen, tomēr tās filozofijas un tehniku pirmsākumi parādījās jau daudz agrāk.Darba mērķis ir izpētīt aikido filozofiju, tās izpaušanos caur etiķeti un izprast tās nozīmi šajā cīņas mākslā. Līdz ar to darbā tiks apskatīta arī aikido rašanās un attīstīšanās vēsture, lai saprastu, kā šī filozofija un et...

  16. Fármacos, ETEs, e corpos hídricos

    Directory of Open Access Journals (Sweden)

    Juliana Cristina Barreiro

    2007-12-01

    Full Text Available Na última década, especial atenção tem sido dada a presença de compostos farmacêuticos no ambiente aquático; uma vez que o aporte contínuo e a persistência de várias dessas substâncias podem trazer danos irreversíveis à biota. Sendo assim, o desenvolvimento e aplicação de novas tecnologias de tratamento que permitam a remoção ou diminuição desses contaminantes tem sido objeto de interesse na área de saneamento ambiental. Entretanto, a não existência de programas específicos de monitoramento nas ETEs, impossibilita a avaliação do comportamento dos fármacos nas plantas instaladas. O presente trabalho ilustra os principais fatores envolvidos no aporte desses contaminantes e apresenta um alerta do caminho a ser percorrido, na implementação de sistemas de tratamento adequados para minimizar a deterioração dos ecossistemas aquáticos.

  17. Improvement of Heavy Oil Recovery in the VAPEX Process using Montmorillonite Nanoclays Amélioration de la récupération d’huile lourde par utilisation de nanoargiles de Montmorillonite dans le procédé VAPEX

    Directory of Open Access Journals (Sweden)

    Pourabdollah K.

    2011-10-01

    Full Text Available In this paper, the nanoclay particles were introduced as mobile adsorbents in oil reservoirs to adsorb the asphaltenes, reduce the viscosity and enhance the dispersion. The objective of this paper is experimental investigation of enhanced heavy oil recovery using in situ nanoparticles for the first time. Moreover, two thermal analysis methods (thermogravimetry and differential thermal analysis were used to analyze the asphaltene content of residue hydrocarbons in the swept chambers in nano-assisted and conventional VAPEX processes. Experiments were carried out using Iranian heavy oil and propane: the setup consisted of two sand-packed cells; one packed only with glass beads as the oil matrix and the other with glass beads and modified montmorillonite as the nanoclay, while they had similar porosity and permeability. The content of deposited asphaltene in swept matrixes, the propagation pattern of vapor chambers in heavy oil matrixes, and the rates of solvent consumption and oil production were determined. The results elucidated that montmorillonite changed the matrix heterogeneity and led to forming enhanced breakthroughs, to increasing the interfacial surface of vapor/bitumen and to accelerating the oil production. It was found that not only was the rate of vapor injection diminished, but the heavy oil recovery was also markedly enhanced by 30(±4%. Dans cet article, on decrit l’utilisation de particules de nanoargile en tant qu’adsorbant mobile dans des reservoirs d’huile afin d’adsorber les asphaltenes, reduire la viscosite de l’huile et renforcer la dispersion. L’objectif de cet article consiste en la description d’une etude experimentale de recuperation amelioree d’huile lourde par l’utilisation de nanoparticules in situ. Ce qui constitue une premiere. En outre, deux methodes d’analyse thermique (thermogravimetrie et analyse thermique differentielle ont ete utilisees pour analyser la teneur en asphaltene des residus d

  18. Preliminary project of s Thomson scattering system for the ETE tokamak; Projeto preliminar de um sistema de espalhamento Thomson para o Tokamak ETE

    Energy Technology Data Exchange (ETDEWEB)

    Berni, Luiz Angelo

    1997-12-31

    This report presents the preliminary project of the injection and laser light block system for the Thomson (ET) scattering diagnostic to be implanted at the ETE spheric tokamak of the Instituto Nacional de Pesquisas Espaciais (INPE/LAP). Also, a scanning system for the optics of scattered light 4 refs., 26 figs.

  19. Phylogeographic analyses of submesophotic snappers Etelis coruscans and Etelis "marshi" (family Lutjanidae reveal concordant genetic structure across the Hawaiian Archipelago.

    Directory of Open Access Journals (Sweden)

    Kimberly R Andrews

    Full Text Available The Hawaiian Archipelago has become a natural laboratory for understanding genetic connectivity in marine organisms as a result of the large number of population genetics studies that have been conducted across this island chain for a wide taxonomic range of organisms. However, population genetic studies have been conducted for only two species occurring in the mesophotic or submesophotic zones (30+m in this archipelago. To gain a greater understanding of genetic connectivity in these deepwater habitats, we investigated the genetic structure of two submesophotic fish species (occurring ∼200-360 m in this archipelago. We surveyed 16 locations across the archipelago for submesophotic snappers Etelis coruscans (N = 787 and E. "marshi" (formerly E. carbunculus; N = 770 with 436-490 bp of mtDNA cytochrome b and 10-11 microsatellite loci. Phylogeographic analyses reveal no geographic structuring of mtDNA lineages and recent coalescence times that are typical of shallow reef fauna. Population genetic analyses reveal no overall structure across most of the archipelago, a pattern also typical of dispersive shallow fishes. However some sites in the mid-archipelago (Raita Bank to French Frigate Shoals had significant population differentiation. This pattern of no structure between ends of the Hawaiian range, and significant structure in the middle, was previously observed in a submesophotic snapper (Pristipomoides filamentosus and a submesophotic grouper (Hyporthodus quernus. Three of these four species also have elevated genetic diversity in the mid-archipelago. Biophysical larval dispersal models from previous studies indicate that this elevated diversity may result from larval supplement from Johnston Atoll, ∼800 km southwest of Hawaii. In this case the boundaries of stocks for fishery management cannot be defined simply in terms of geography, and fishery management in Hawaii may need to incorporate external larval supply into management

  20. Digital controlled pulsed electric system of the ETE tokamak. First report; Sistema eletrico pulsado com controle digital do Tokamak ETE (experimento Tokamak esferico). Primeiro relatorio

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Luis Felipe de F.P.W.; Del Bosco, Edson

    1997-12-31

    This reports presents a summary on the thermonuclear fusion and application for energy supply purposes. The tokamak device operation and the magnetic field production systems are described. The ETE tokamak is a small aspect ratio device designed for plasma physics and thermonuclear fusion studies, which presently is under construction at the Laboratorio Associado de Plasma (LAP), Instituto Nacional de Pesquisas Espaciais (INPE) - S.J. dos Campos - S. Paulo. (author) 55 refs., 40 figs.

  1. Une alternative au cobalt pour la synthese de nanotubes de carbone monoparoi par plasma inductif thermique

    Science.gov (United States)

    Carrier, Jean-Francois

    Les nanotubes de carbone de type monoparoi (C-SWNT) sont une classe recente de nanomateriaux qui ont fait leur apparition en 1991. L'interet qu'on leur accorde provient des nombreuses proprietes d'avant-plan qu'ils possedent. Leur resistance mecanique serait des plus rigide, tout comme ils peuvent conduire l'electricite et la chaleur d'une maniere inegalee. Non moins, les C-SWNT promettent de devenir une nouvelle classe de plateforme moleculaire, en servant de site d'attache pour des groupements reactifs. Les promesses de ce type particulier de nanomateriau sont nombreuses, la question aujourd'hui est de comment les realiser. La technologie de synthese par plasma inductif thermique se situe avantageusement pour la qualite de ses produits, sa productivite et les faibles couts d'operation. Par contre, des recherches recentes ont permis de mettre en lumiere des risques d'expositions reliees a l'utilisation du cobalt, comme catalyseur de synthese; son elimination ou bien son remplacement est devenu une preoccupation importante. Quatre recettes alternatives ont ete mises a l'essai afin de trouver une alternative plus securitaire a la recette de base; un melange catalytique ternaire, compose de nickel, de cobalt et d'oxyde d'yttrium. La premiere consiste essentiellement a remplacer la proportion massique de cobalt par du nickel, qui etait deja present dans la recette de base. Les trois options suivantes contiennent de nouveaux catalyseurs, en remplacement au Co, qui sont apparus dans plusieurs recherches scientifiques au courant des dernieres annees: le dioxyde de zircone (ZrO2), dioxyde de manganese (MnO2) et le molybdene (Mo). La methode utilisee consiste a vaporiser la matiere premiere, sous forme solide, dans un reacteur plasma a haute frequence (3 MHz) a paroi refroidi. Apres le passage dans le plasma, le systeme traverse une section dite de "croissance", isolee thermiquement a l'aide de graphite, afin de maintenir une certaine plage de temperature favorable a la

  2. El financiamiento de la agricultura en el valle de Cañete

    Directory of Open Access Journals (Sweden)

    1986-01-01

    Full Text Available Depuis les années 30, le financement du Banco Agrario joue un rôle important dans le développement de l'agriculture de la Vallée de Cañete et les politiques du crédit s'inscrivent dans le contexte des modèles économiques promus par les différents régimes politiques. Pendant plus d'un demi-siècle, le crédit agricole donne surtout la priorité aux formes sociales de production concentrant la propriété de la terre et le capital il appuie, en outre, le changement de modèle de culture en fonction des besoins du marché et du développement du capitalisme dans l'agriculture.Depuis le début de la présente décennie, la politique agricole, sous l'influence d'un modèle économique néo-libéral, n'a cessé d'élever le coût de l'argent, de réduire l'offre de crédit agricole réel et d'appliquer une politique des prix défavorable au producteur, entraînant une décapitalisation des unités agricoles, ce qui n'a fait qu'aggraver la crise de l'agriculture. Actuellement, on note qu'un rôle important est donné au crédit individuel alloué aux nouveaux producteurs 'parcellaires', mais cette politique a pour effet de supprimer les services techniques des Coopératives Agricoles de Production, accélérant par-là même la décadence de celles-ci. Cependant, la nouvelle politique du crédit permet d'entrevoir quelques changements positifs, parmi lesquels la réduction du taux d'intérêt pour les prêts, sans que toutefois il existe encore de cohérence entre la politique du crédit, la politique agricole, et la politique globale du gouvernement. L'importance du crédit agricole informel est également décisive dans la production agricole de la zone il a pour principaux agents: les commerçants, l'agro-industrie et les établissements commerciaux fournisseurs d'intrants. El financiamiento de la Banca Estatal, desde la década del 30, desempeña un importante rol en el desarrollo de la agricultura del Valle de Cañete y las pol

  3. Etude des polysaccharides pariétaux de la pomme extraction et caractérisation par des methodes chimiques et enzymatiques.

    NARCIS (Netherlands)

    Renard, C.M.G.C.

    1989-01-01

    La composition de la paroi de pomme et les connections entre polymeres parietaux ont ete etudies par des methodes chimiques et enzymatiques. La paroi de pomme, riche en pectines et cellulose ne contient pas d'acides phenoliques. La pectine soluble, extraite par un agent chelatant est pauvre en oses

  4. Techniques d'inspection par ondes guidees ultrasonores d'assemblages brases dans des reacteurs aeronautiques =

    Science.gov (United States)

    Comot, Pierre

    a celle utilisee en simulation. Les parametres experimentaux ayant ete choisis en accord avec l'optimisation effectuee lors des simulations et apres une premiere optimisation du procede experimental. Finalement les resultats experimentaux confirment les resultats obtenus en simulation, et demontrent le potentiel de la methode developpee.

  5. El proceso de parcelación de las cooperativas agrarias del valle de Cañete

    Directory of Open Access Journals (Sweden)

    1986-01-01

    Full Text Available Dans la Basse Vallée du Cañete, comme sur l'ensemble de la Côte péruvienne, les entreprises associatives installées par la Réforme Agraire au début des années 70, ont été parcellisées entre les coopérateurs, transformant ainsi profondément la structure agraire. L'article analyse l'origine et les causes de ce processus de démembrement, résultat à la fois d'une nette volonté politique, d'une conjoncture économique défavorable, des difficultés d'organisation rencontrées par les coopératives, de la volonté des coopérateurs d'avoir accès à la propriété privée, mais aussi de la confrontation des systèmes de production: grande coopérative/moyenne propriété modernisée/petite propriété diversifiée. La mise en place du nouveau système de production parcellaire montre une inégale efficacité des nouveaux agriculteurs et des nouvelles structures que sont les coopératives de services. Les perspectives qui s'ouvrent à l'agriculture de la Vallée et à son organisation laissent entrevoir la possibilité d'un changement lent mais profond vers une intensification de la production si les conditions globales (stabilité du cadre légal, recherche et assistance technique au producteur, crédit et prix rémunérateurs, etc. sont favorables. En conclusion, l'article propose quelques orientations allant dans ce sens. En el Valle de Cañete, como en la Costa peruana en general, las empresas asociativas instauradas por la Reforma Agraria, al inicio de la década de los 70, fueron parceladas entre los socios, transformándose así profundamente la estructura agraria. El artículo analiza el origen y las causas de este proceso de parcelación, resultado a la vez de una voluntad política definida, de una coyuntura económica adversa, de las dificultades de organización encontradas por las cooperativas, de la voluntad de los socios de tener acceso a la 'parcela propia' pero más aún, de la confrontación de los sistemas de

  6. WearETE: A Scalable Wearable E-Textile Triboelectric Energy Harvesting System for Human Motion Scavenging.

    Science.gov (United States)

    Li, Xian; Sun, Ye

    2017-11-17

    In this paper, we report the design, experimental validation and application of a scalable, wearable e-textile triboelectric energy harvesting (WearETE) system for scavenging energy from activities of daily living. The WearETE system features ultra-low-cost material and manufacturing methods, high accessibility, and high feasibility for powering wearable sensors and electronics. The foam and e-textile are used as the two active tribomaterials for energy harvester design with the consideration of flexibility and wearability. A calibration platform is also developed to quantify the input mechanical power and power efficiency. The performance of the WearETE system for human motion scavenging is validated and calibrated through experiments. The results show that the wearable triboelectric energy harvester can generate over 70 V output voltage which is capable of powering over 52 LEDs simultaneously with a 9 × 9 cm² area. A larger version is able to lighten 190 LEDs during contact-separation process. The WearETE system can generate a maximum power of 4.8113 mW from hand clapping movements under the frequency of 4 Hz. The average power efficiency can be up to 24.94%. The output power harvested by the WearETE system during slow walking is 7.5248 µW. The results show the possibility of powering wearable electronics during human motion.

  7. Los sistemas de producción frutícolas en el valle de Cañete

    Directory of Open Access Journals (Sweden)

    1986-01-01

    Full Text Available La Vallée du Cañete offre des conditions favorables au développement de l'arboriculture fruitière, en particulier le pommier et les agrumes. Un certain nombre d'unités de production, très diverses, regroupant des petits et moyens propriétaires, ainsi que d'anciens coopérateurs ayant reçu une parcelle après le démembrement des coopératives, se sont spécialisées dans ces spéculations, mettant en place des systèmes de culture et de production différents. L'article analyse les meilleures combinaisons, système de culture/système de production, tant sur le plan agronomique qu'économique, pour cerner les possibilités futures de développement des cultures fruitières. Il apparaît que deux systèmes de production efficaces, mais apparemment antagonistes, pourraient en fait se développer parallèlement: - une arboriculture basée sur des techniques culturales traditionnelles (cultures associées avec traction attelée et fumure organique seule, fortement améliorée par les progrès scientifiques récents (variétés améliorées, emploi raisonné des intrants, pesticides et engrais ce type d'arboriculture conviendrait aux petites exploitations, majoritaires dans la zone d'étude. - une arboriculture 'moderne' reposant sur une forte mécanisation, des cultures intensives de type industriel (agrumes en particulier et des surfaces importantes de 10 à 50 hectares. El Valle de Cañete ofrece condiciones favorables para el desarrollo de la fruticultura, manzanos y cítricos especialmente. Un número determinado de unidades de producción, muy diversas, que incluyen tanto pequeños y medianos propietarios así como antiguos cooperativistas quienes recibieron una parcela después del desmantelamiento de las cooperativas, se especializaron en aquellas producciones, implementando diferentes sistemas de cultivo y de producción. El artículo analiza las mejores combinaciones, sistemas de cultivo/sistema de producción, tanto a nivel agron

  8. Stray light analysis for the Thomson scattering diagnostic of the ETE Tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Berni, L. A. [Instituto Nacional de Pesquisas Espaciais (INPE), Laboratorio Associado de Sensores e Materiais (LAS), 12.227-010 Sao Jose dos Campos, SP (Brazil); Albuquerque, B. F. C. [Instituto Nacional de Pesquisas Espaciais (INPE), Engenharia e Tecnologia Espaciais, Divisao de Eletronica Aeroespacial, 12.227-010 Sao Jose dos Campos, SP (Brazil)

    2010-12-15

    Thomson scattering is a well-established diagnostic for measuring local electron temperature and density in fusion plasma, but this technique is particularly difficult to implement due to stray light that can easily mask the scattered signal from plasma. To mitigate this problem in the multipoint Thomson scattering system implemented at the ETE (Experimento Tokamak Esferico) a detailed stray light analysis was performed. The diagnostic system was simulated in ZEMAX software and scattering profiles of the mechanical parts were measured in the laboratory in order to have near realistic results. From simulation, it was possible to identify the main points that contribute to the stray signals and changes in the dump were implemented reducing the stray light signals up to 60 times.

  9. Las monedas de Salvacañete (Cuenca y su significado en el tesoro

    Directory of Open Access Journals (Sweden)

    Blázquez, Cruces

    1998-12-01

    Full Text Available The absence of coin-illustrations from Cabre's 1936 publication of the 1st century BC assemblage from Salvacañete (Cuenca has been a source of confusion. Previous accounts of the coin-element have usually been limited to the pieces housed either in the Museo Arqueológico Nacional, Madrid, or in the Museo de Cuenca. The present revision takes account additionally of specimens deposited by Gómez-Moreno in the Instituto Valencia de Don Juan, Madrid, which almost certainly form part of the original find. The numismatic material appears to have been deliberately chosen for its iconographic content, with issues featuring either horses or bulls being preferred to contemporary coins of other types. A possible explanation is that they represent offerings to a divinity with animal associations; the depiction of a bee on one of the assemblage's non-numismatic items would suggest a cult similar to that of Artemis.Las monedas del Tesoro de Salvacañete (Cuenca del s. I a.C, fueron publicadas en 1936 sin ilustraciones por lo que existen datos muy discordantes. Hasta hoy se habían identificado las piezas del Museo Arqueológico Nacional y las del Museo de Cuenca. Añadimos aquí por primera vez los posibles ejemplares depositados por Gómez Moreno en el Instituto Valencia de Don Juan de Madrid y proponemos una reconstrucción de este material numismático. El estudio monetario parece indicar una clara selección de las monedas por su iconografía con un objetivo cultual en el que el caballo y el toro tendrían especial significado, obviando otros tipos monetales que por cronología deberían estar presentes. Podría tratarse de exvotos a una divinidad relacionada con los animales, quizás semejante a una Artemis a juzgar por la abeja representada en uno de los objetos del Tesoro.

  10. Ionisation D'atomes Par un Laser Carbon Dioxide Intense Par L'effet Tunnel

    Science.gov (United States)

    Xiong, Wei

    Cette these decrit des experiences d'ionisation d'atomes (Xe et K) par un laser CO_2 intense. Des spectrometres de masse et d'energie electronique ont ete developpes pour mesurer le nombre d'ions crees et l'energie des electrons acceleres par le gradient spatial du champ laser. Des details sur ces mesures sont fournis et justifies. On a mesure des energies d'electrons jusqu'a 1000eV, a une intensite de 10^{14} W/cm^2. Les mesures experimentales sont comparees avec deux types de theorie, qui decrivent le processus d'ionisation dans deux limites: l'interaction entre electron et noyau est beaucoup plus forte que celle entre electron et champ laser (processus multiphotonique), ou l'inverse (effect tunnel). Les resultats montrent que la courbe du nombre d'ions crees en fonction de l'intensite n'est pas tres sensible aux details du processus d'ionsisation. Par contre les spectres d'energie des electrons dependent fortement du processus d'ionisation, et on peut en deduire le taux d'ionisation. On trouve que la theorie multiphotonique ne fournit pas une explication satisfaisante aux resultats experimentaux, mais que la theorie de l'effet tunnel s'ajuste bien si on suppose que le seuil d'ionisation peut etre deplace legerement par le champ laser. Le deplacement necessaire du seuil est estime dans cette these, mais une explication theorique reste a trouver.

  11. Temperature dependence of o-Ps annihilation lifetime in non-uniform cylindrical pores in comparison with ETE model

    Energy Technology Data Exchange (ETDEWEB)

    Khaghani, Morteza, E-mail: m.khaghani@pgs.usb.ac.ir; Mehmandoost-Khajeh-Dad, Ali Akbar, E-mail: mehmandoost@phys.usb.ac.ir

    2017-04-01

    Highlights: • Using the well known multi-physics program COMSOL calculating o-Ps annihilation lifetime in complex geometries. • Investigation of shape non-uniformity of cylindrical pores on o-Ps annihilation lifetime. • Verifying temperature dependency of o-Ps lifetime in non-uniform cylindrical pores. • Suggesting PALS at low temperature as a method to verify pore uniformity in porous material. - Abstract: Ortho-positronium (o-Ps) annihilation lifetime was calculated in non-uniform cylinder-shaped pores by solving Schrodinger equation using a well-known multi-physics program called COMSOL. The o-Ps annihilation lifetime variation in terms of temperature was calculated on the basis of ETE model via a numerical method. The COMSOL simulations indicate that as long as the pore is uniform cylinder-shaped, the results agree with those of two-dimensional ETE model, whereas deformations in the cylinder shape (indentation or protrusion) change the temperature behavior of ETE model and, thereby, higher values are predicted for o-Ps lifetime in the pore at lower temperatures. The geometry of the non-uniform cylinder-shaped pores, which is accompanied by empirical evidence, can be used for the analysis of empirical results obtained from positron lifetime spectroscopy in different temperatures.

  12. Plates-formes de microscopie et fluorescence par resonance de plasmons de surface appliquees a l'imagerie cellulaire

    Science.gov (United States)

    Chabot, Vincent

    L'elaboration de nouveaux medicaments repose sur les etudes pharmacologiques, dont le role est d'identifier de nouveaux composes actifs ou de nouvelles cibles pharmacologiques agissant entre autres au niveau cellulaire. Recemment, la detection basee sur la resonance des plasmons de surface (SPR) a ete appliquee a l'etude de reponses cellulaires. Cette methode de detection, permettant d'observer des variations d'indice de refraction associes a de faibles changements de masse a la surface d'un metal, a l'avantage de permettre l'etude d'une population de cellules vivantes en temps reel, sans necessiter l'introduction d'agents de marquage. Pour effectuer la detection au niveau de cellules individuelles, on peut employer la microscopie SPR, qui consiste a localiser spatialement la detection par un systeme d'imagerie. Cependant, la detection basee sur la SPR est une mesure sans marquage et les signaux mesures sont attribues a une reponse moyennee des differentes sources cellulaires. Afin de mieux comprendre et identifier les composantes cellulaires generant le signal mesure en SPR, il est pertinent de combiner la microscopie SPR avec une modalite complementaire, soit l'imagerie de fluorescence. C'est dans cette problematique que s'insere ce projet de these, consistant a concevoir deux plates-formes distinctes de microscopie SPR et de fluorescence optimisees pour l'etude cellulaire, de sorte a evaluer les possibilites d'integration de ces deux modalites en un seul systeme. Des substrats adaptes pour chaque plate-forme ont ete concus et realises. Ces substrats employaient une couche d'argent passivee par l'ajout d'une mince couche d'or. La stabilite et la biocompatibilite des substrats ont ete validees pour l'etude cellulaire. Deux configurations permettant d'ameliorer la sensibilite en sondant les cellules plus profondement ont ete evaluees, soit l'emploi de plasmons de surface a longue portee et de guides d'onde a gaine metallique. La sensibilite accrue de ces

  13. Viabilidade da incorporação do lodo de estação de tratamento de esgoto (ETE em massa cerâmica para produção de blocos

    Directory of Open Access Journals (Sweden)

    C. R. L. da Silva

    2015-03-01

    Full Text Available O lodo gerado nas estações de tratamento de esgoto tem se tornado um problema crescente sendo considerado como resíduo. Este trabalho estudou a viabilidade da incorporação do lodo de estação de tratamento de esgoto (ETE em massa cerâmica para produção de blocos. Para isso, amostras de lodo foram coletadas na ETE Verde da SANEPAR no Município de Ponta Grossa, PR e de argila da Cerâmica S. Gerônimo no município de Prudentópolis, PR. O lodo na ETE Verde foi submetido a um processo de higienização, o qual reduz significativamente a concentração de patógenos no resíduo. O processo utilizado foi a caleação, que promove a estabilização, desinfecção química e térmica através da adição e mistura da cal ao lodo numa porcentagem de 30% a 50% da massa seca de lodo. Para a caracterização do lodo e da argila foram realizadas análises de difração de raios X, análise térmica diferencial e termogravimétrica, fluorescência de raios X e distribuição granulométrica. Foram estudadas composições com adições de 5 a 50% em massa do lodo na massa cerâmica. Após a mistura do lodo com as argilas, as amostras foram conformadas por prensagem uniaxial e sinterizadas a 900 ºC, 1000 ºC e 1100 ºC. As amostras sinterizadas foram caracterizadas por medidas de absorção de água, porosidade aparente, resistência mecânica, difração de raios X e microscopia eletrônica de varredura. Os resultados mostraram que a adição do lodo até 25% da massa da argila atende a todos os parâmetros preconizados pelas normas vigentes para fabricação dos blocos cerâmicos.

  14. The effect of allergen-induced bronchoconstriction on concentration of 5-oxo-ETE in exhaled breath condensate of house dust mite-allergic patients.

    Science.gov (United States)

    Kowal, K; Gielicz, A; Sanak, M

    2017-10-01

    Arachidonic acid metabolites regulate several aspects of airway function including inflammation, muscle contraction and mucous secretion. The aim of this study was to evaluate concentration of selected 5-lipoxygenase- and cyclooxygenase-derived eicosanoids in exhaled breath condensate (EBC) during allergen-induced bronchoconstriction. The study was performed on 24 allergic rhinitis/asthma patients sensitized to a house dust mite (HDM) Dermatophagoides pteronyssinus (Dp) and 13 healthy controls (HCs). Bronchial challenge with Dp extract was performed only in the allergic patients. EBC samples were collected before (T0 ) and during Dp-induced bronchoconstriction (TEAR ). Eicosanoid concentration was measured using HPLC-tandem mass spectrometry. Significant bronchoconstriction after Dp challenge was demonstrated in 15 patients (Rs), while in 9 patients (NRs) no asthmatic response could be detected. At T0 the most abundant eicosanoids in EBC of HDM-allergic patients were LTB4 and 5-oxo-ETE, while in HCs EBC concentration of LTB4 was significantly greater than that of 5-oxo-ETE. Allergen challenge resulted in significant increase in EBC concentration of 5-oxo-ETE, LTD4 and 8-iso-PGE2 only in Rs. At TEAR , the relative change of 5-oxo-ETE concentration in EBC correlated with decrease of peripheral blood eosinophilia (R = -0.774; P = .0012). Moreover, the relative increase of 5-oxo-ETE in EBC at TEAR significantly correlated with the severity of the subsequent late asthmatic response (R = 0.683, P = .007). Our study demonstrates significant up-regulation of 5-oxo-ETE synthesis in HDM-allergic patients and indicates possible involvement of that mediator in the pathogenesis of allergic asthma. © 2017 John Wiley & Sons Ltd.

  15. Utilisation de l'essai comete et du biomarqueur gamma-H2AX pour detecter les dommages induits a l'ADN cellulaire par le 5-bromodeoxyuridine post-irradiation

    Science.gov (United States)

    La Madeleine, Carole

    Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par

  16. Beach sediments drift study by means of radioactive tracers; L'etude du transport littoral par la methode des traceurs radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Hours, R. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires; Jaffry, P. [Electricite de France (EDF), 78 - Chatou (France). Lab. National d' Hydraulique

    1959-07-01

    The present state of the sediments drift studies by means of radioactive tracers is exposed. Various processes of labelling, immersion and detection, used in France and other countries, are reviewed. A more extended analysis of some aspects of the problem by the same authors can be found in 'La Houille Blanche', number 3, may-june 1959 (Rapport C.E.A. number 1269). (author) [French] L'etude du transport littoral des sediments et galets par la methode des traceurs radioactifs est en plein developpement. Le present rapport precise l'etat actuel de la question. Les techniques de marquage, d'immersion et de detection utilisees en France et a l'etranger sont decrites; une analyse plus detaillee de certains aspects de la question est presentee par les memes auteurs dans 'La Houille Blanche', numero 3, mai-juin 1959 (Rapport C.E.A. numero 1269). (auteur)

  17. Experimental contamination of pink shrimps by caesium 137; Contamination experimentale de crevettes roses par le cesium 137

    Energy Technology Data Exchange (ETDEWEB)

    Ancellin, J.; Michon, G.; Vilquin, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1965-07-01

    The authors describe first of all the technique used for the determination of cesium 137 concentration factors in the pink shrimp (Leander Serratus Pennant). Experiments over three months have shown that the specific activity of the shrimps becomes stable between the thirtieth and the fortieth day. The concentration factors then have values between 30 and 40. These results are similar to those obtained by other authors. (authors) [French] Les auteurs decrivent tout d'abord la technique utilisee pour la determination des facteurs de concentration du Cesium 137 chez la crevette rose (Leander Serratus Pennant). Le resultat des experimentations menees pendant trois mois montre que l'activite specifique des crevettes se stabilise entre le trentieme et le quarantieme jour. Les facteurs de concentration se situent alors entre 30 et 40, Ces donnees sont comparables a celles obtenues par d'autres auteurs. (auteur)

  18. Complicaciones tardías en diabetes mellitus tipo 2 en el Hospital II Essalud - Cañete

    Directory of Open Access Journals (Sweden)

    Charlton Fernando Untiveros Mayorga

    2004-04-01

    Full Text Available Objetivo: Determinar las características clínicas y las complicaciones tardías en los pacientes con diabetes tipo 2 atendidos en los consultorios de medicina general y del Programa de Diabetes del Hospital II EsSALUD-Cañete. Material y Métodos: Se realizó un estudio descriptivo de serie de casos en el que se evaluaron 94 pacientes con diabetes tipo 2 elegidos aleatoriamente durante su control ambulatorio, realizándose una entrevista y evaluación clínica durante los meses de junio y julio del 2001. Resultados: La población de pacientes estudiada tuvo una edad promedio de 64.56 + 11.61. Cincuenta y tres pacientes eran mujeres (56.4%. El 68.1% de los pacientes recibían hipoglicemiantes orales y el 11.7% requerían del uso de insulina. Los transtornos lipídicos predominantes fueron la elevación del LDL-Colesterol y disminución del HDL-Colesterol. La retinopatía diabética (88.9% e hipertensión arterial (61.3% fueron las complicaciones más frecuentes. Vasculopatía periférica, neuropatía periférica y neuropatía autonómica fueron otras complicaciones crónicas frecuentes halladas en la población de estudio. Conclusiones: Las complicaciones cardiovasculares (micro y macrovasculares en la población de pacientes con diabetes tipo 2 atendidos ambulatoriamente en el Hospital II EsSALUD-Cañete fueron las más frecuentes. (Rev Med Hered 2004; 15:64-69.

  19. A Human-Centered Platform for HIV Infection Reduction in New York: Development and Usage Analysis of the Ending the Epidemic (ETE) Dashboard.

    Science.gov (United States)

    Joshi, Ashish; Amadi, Chioma; Katz, Benjamin; Kulkarni, Sarah; Nash, Denis

    2017-12-11

    Dashboards have been increasingly used in clinic-based interventions, such as clinical performance improvement and monitoring risk of hospital readmissions, and are now gaining traction in population-based interventions, especially in disease assessment. We describe the design, development, and usage analysis of a geovisualization dashboard, the Ending the Epidemic (ETE) Dashboard. The ETE dashboard is a tool developed to track New York's progress towards achieving the goal of its ETE Initiative, to reduce new HIV infections from 3000 per year to 750 per year by the end of 2020. The ETE dashboard was adapted from an existing human-centered geovisualization platform, SanaViz, an Internet-enabled, interactive app incorporating principles of human-centered design and cognitive fit theory to enhance visual exploration of population health data. Usage evaluation of the ETE geovisualization dashboard was conducted using Google Analytics over a 4-week period from March 19 to April 18, 2016. The aim was to monitor user activity and analyze traffic on the ETE dashboard using evidence-based metrics that can provide adequate feedback to enhance its utilization. Usage was characterized based on three metrics: (1) number of unique visits to each page, (2) average time on each page in seconds, and (3) page bounce rate (ie, percentage of visits where user left the site immediately after viewing just a single page). Further analysis was also conducted by cross-tabulating specific usage metrics. Of 860 sessions, 324 sessions were initiated by unique users (37.7%). The most common acquisition channels included direct source (353/860, 41.0%); followed by referral traffic (340/860, 39.5%) and organic search (134/860, 15.5%). Usage statistics indicate that for the 860 sessions initiated by both new and returning users, the average viewing time was 8 minutes, 51 seconds, and the bounce rate was 46%. These statistics reflect positive results given that prior literature estimates an

  20. Detection de la fin de la compaction des anodes par le son

    Science.gov (United States)

    Sanogo, Bazoumana

    L'objectif de ce projet etait de developper un outil de controle en temps reel du temps de compaction en se servant du son genere par le vibrocompacteur pendant le formage des anodes crues. Ainsi, une application a ete developpee pour l'analyse des sons enregistres. Des essais ont ete realises avec differents microphones pour une meilleure qualite des mesures et un a ete choisi pour la suite du projet. De meme, differents tests ont ete realises sur des anodes de laboratoire ainsi que des anodes a l'echelle industrielle afin de mettre en place une methode pour la detection du temps optimal necessaire au formage des anodes. Les travaux au laboratoire de carbone a l'Universite du Quebec a Chicoutimi (UQAC) ont consiste a l'enregistrement de son des anodes fabriquees sur place avec differentes configurations; et a la caracterisation de certaines anodes de l'usine. Les anodes fabriquees au laboratoire sont reparties en deux groupes. Le premier regroupe les anodes pour la validation de notre methode. Ce sont des anodes produites avec des temps de compaction differents. Le laboratoire de carbone a l'UQAC est unique et il est possible de produire des anodes avec les memes proprietes que celles des anodes industrielles. Par consequent, la validation initialement prevue a l'usine a ete effectuee avec les anodes de laboratoire. Le deuxieme groupe a servi a etudier les effets des matieres premieres sur le temps de compaction. Le type de coke et le type de brai ont constitue les differentes variations dans ce deuxieme groupe. Quant aux tests et mesures a l'usine, ils ont ete realises en trois campagnes de mesure. La premiere campagne en juin 2014 a servi a standardiser et a trouver le meilleur positionnement des appareils pour les mesures, a regler le logiciel et a faire les premieres mesures. Une deuxieme campagne en mai 2015 a fait l'objet d'enregistrement de son en classant les anodes selon differents temps de compaction. La troisieme et derniere campagne en decembre 2015 a

  1. Par-tjek Manualen

    DEFF Research Database (Denmark)

    Trillingsgaard, Tea; Due, Mattias Stølen; Nørr Fentz, Hanne

    Par-tjek er et tilbud til par, der ønsker at styrke forholdet og forebygge vanskeligheder. Et Par-tjek består af et indledende online spørgeskema efterfulgt at to samtaler med en psykolog eller lignende vejleder. Ved den sidste samtale modtager parret en personlig feedback-rapport, som de kan...... arbejde videre med. Samtalerne kombinerer elementer af udredning, caseformulering, psykoedukation og parterapi. Par-tjek manualen er en vejledning til fagpersoner, der arbejder med Par-tjek....

  2. Project and analysis of the toroidal magnetic field production circuits and the plasma formation of the ETE (Spherical Tokamak Experiment) tokamak; Projeto e analise dos circuitos de producao de campo magnetico toroidal e de formacao do plasma do Tokamak ETE (Experimento Tokamak Esferico)

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Luis Filipe F.P.W.; Bosco, Edson del

    1994-12-31

    This report presents the project and analysis of the circuit for production of the toroidal magnetic field in the Tokamak ETE (Spherical Tokamak Experiment). The ETE is a Tokamak with a small-aspect-ratio parameter to be used for studying the plasma physics for the research on thermonuclear fusion. This machine is being constructed at the Laboratorio Associado de Plasma (LAP) of the Instituto Nacional de Pesquisas Espaciais (INPE) in Sao Jose dos Campos, SP, Brazil. (author). 20 refs., 39 figs., 4 tabs.

  3. Coating of evaporation concentrates with bitumen. Progress Report No. 1; Enrobage des concentrats d'evaporation par le bitume. Etat d'avancement no. 1

    Energy Technology Data Exchange (ETDEWEB)

    Rodier, J.; Lefillatre, G.; Rodi, L.; Cudel, Y. [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1968-07-01

    Laboratory tests have been carried out on the coating by bitumen of evaporation concentrates having a free nitric acidity of 1 N or 2.5 N, and a high mineralization (400 gm/litre). In order to neutralize the free acidity and to trap the radio-elements, these concentrates have been subjected before coating to various treatments designed to decrease the solubility. As a result of these treatments, sludges were obtained which could be coated directly with the bitumen. By measuring the radioactive diffusion factors of the bitumen coated products immersed both in ordinary and sea water, it was possible to compare the efficiency of the processes developed and of the various types of bitumen used. On the whole the radioactive diffusion tests were satisfactory and the process using successive co-precipitations (hydroxides, nickel ferrocyanide, barium sulphate) was chosen. From the bitumens tried out, a straight - asphalt, Mexphalt 40/50 was selected for low and medium activity concentrates as it ensures good isolation of the radio-elements; an air-blowing asphalt, Mexphalte R 90/40, was chosen for concentrates of high activity because of its higher resistance to irradiation. As a result of this work, a simple coating technology was evolved and pilot experiments will soon begin. Briefly, it appears that although a method for coating evaporation concentrates with bitumen has been defined, it will inevitably be necessary to devise a specific decontamination process each time that a new type of concentrate is encountered (composition, nature of the salts, radio-element distribution). (author) [French] Des essais d'enrobage par le bitume des concentrats d'evaporation ayant une acidite nitrique libre de 1 N ou de 2.5 N et une mineralisation elevee (400 g/litre) ont ete realises en laboratoire. Dans le but de neutraliser l'acidite libre et de pieger les radio-elements, ces concentrats ont ete soumis avant leur enrobage a divers traitements d

  4. Incorporação de lodo da estação de tratamento de esgoto (ETE em cerâmica vermelha

    Directory of Open Access Journals (Sweden)

    I. O. R. Areias

    Full Text Available Resumo Este trabalho teve por objetivo avaliar a incorporação de resíduo de estação de tratamento de esgoto (ETE na produção de cerâmica vermelha. As matérias-primas utilizadas foram: massa cerâmica argilosa e resíduo de ETE provenientes do município de Campos dos Goytacazes - RJ. As matérias-primas foram caracterizadas pelas técnicas de fluorescência de raios X e difração de raios X; além disso, foi determinada a área de superfície específica das mesmas por meio das técnicas de BET e azul de metileno. O comportamento térmico do resíduo de ETE foi avaliado por meio de análise termogravimétrica. Formulações foram preparadas com 0, 2,5, 10 e 15% em massa de resíduo de ETE incorporados à massa argilosa. Corpos de prova foram confeccionados por prensagem uniaxial a 20 MPa com 8% de umidade para calcinação a 950 °C. As propriedades físicas e mecânicas avaliadas das cerâmicas calcinadas foram retração linear, absorção de água e resistência à compressão. A microestrutura destas peças foi investigada com auxílio de microscopia eletrônica de varredura. Os resultados indicaram que este tipo de resíduo deve ser incorporado em pequenas quantidades (até 2,5% para não prejudicar as propriedades físicas e mecânicas da cerâmica.

  5. CAÑETE DEL PERÚ, ¿PARA LA DEFENSA DEL REINO? UN CASO DE BUROCRACIA Y NEGOCIACIÓN POLÍTICA, SIGLO XVI

    Directory of Open Access Journals (Sweden)

    Susana Aldana Rivera

    2008-01-01

    Full Text Available En este artículo se estudia cómo la fundación de una pequeña ciudad, como Cañete del Perú, es un excelente ejemplo de caso para analizar el juego de la política imperial, la política virreinal e incluso la política local para lograr el apaciguamiento de la violencia militar de la conquista y de control sociopolítico del territorio recientemente establecido como virreinato. Así, para lograrlo el rey debió desarrollar una política imperial que le permitiera conquistar a los conquistadores y contar el apoyo de los poderosos señores locales. El virrey, en este sentido era un personaje clave, y por eso, llega a estas tierras don Andrés Hurtado de Mendoza, II virrey de Cañete, imprimiendo su sello personal en el gobierno virreinal, -pacificando- a los conquistadores con mano dura y negociando con el Inca de Vilcabamba. Para cumplir con su misión, funda ciudades en lugares estratégicos, como Cañete del Perú, punto clave de entrada (o bajada de la sierra sur donde, contando con la anuencia de los señores locales, asienta a algunos recién llegados para que encuentren una forma adecuada de posicionarse en estas nuevas tierras.

  6. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. FooPar......, results based on a empirical analysis on two supercomputers are given. We achieve close-to-optimal performance wrt. theoretical peak performance. Based on this result we conclude that FooPar allows programmers to fully access Scalas design features without suffering from performance drops when compared...

  7. Protection des ions organiques contre les dommages induits a l'ADN par les electrons de basse energie

    Science.gov (United States)

    Dumont, Ariane

    Il a ete demontre que les electrons de basse energie (EBE) peuvent induire des cassures simple brin (CSB) a l'ADN, via la formation d'anions transitoires qui decroissent par attachement dissociatif, ou dans d'autres etats electroniques dissociatifs menant a la fragmentation. Afin d'effectuer une etude complete des effets des electrons de basse energie sur la matiere biologique, il est necessaire de comprendre leur mecanismes d'interaction non seulement avec l'ADN, mais avec les constituants de son environnement. Les histones sont une composante importante de l'environnement moleculaire de l'ADN. Leur charge positive leur permet de s'associer aux groupements phosphate anionique de l'ADN. Le role principal de ces proteines basiques consiste a organiser l'ADN et l'empaqueter afin de former la chromatine. Les cations sont une autre composante importante de la cellule; ils jouent un role dans la stabilisation de la conformation B de l'ADN in vitro par leurs interactions avec les petits et grands sillons de l'ADN, ainsi qu'avec le groupement phosphate charge negativement. Avec les histones, ils participent egalement a la compaction de l'ADN pour former la chromatine. Cette etude a pour but de comprendre comment la presence d'ions organiques (sous forme de Tris et d'EDTA) a proximite de l'ADN modifie le rendement de cassures simple brin induit par les electrons de basse energie. Le Tris et l'EDTA ont-ete choisis comme objet d'etude, puisqu'en solution, ils forment le tampon standard pour solubiliser l'ADN dans les experiences in vitro (10mM Tris, 1mM EDTA). De plus, la molecule Tris possede un groupement amine alors que l'EDTA possede 4 groupements carboxyliques. Ensembles, ils peuvent se comporter comme un modele simple pour les acides amines. Le ratio molaire de 10 :1 de Tris par rapport a l'EDTA a pour but d'imiter le comportement des histones qui sont riches en arginine et lysine, acides amines possedant un groupement amine charge positivement additionnel. Des films d

  8. Modeles numeriques de la stimulation optique de neurones assistee par nanoparticules plasmoniques

    Science.gov (United States)

    Le Hir, Nicolas

    actuelles. Cependant, le mecanisme physique a l'origine de la stimulation lumineuse de neurones, ainsi que celui a l'orgine de la stimulation lumineuse assistee par nanoparticules, n'est a ce jour pas totalement compris. Des hypotheses ont ete formulees concernant ce mecanisme : il pourrait etre photothermique, photomecanique, ou encore photochimique. Il se pourrait egalement que plusieurs mecanismes soient a l'oeuvre conjointement, etant donne la variete des observations. La litterature ne converge pas a ce sujet et l'existence d'un mecanisme commun aux differentes situations n'a pas ete demontree.

  9. Water and sediment dynamics in the context of climate change and variability (Cañete river, Peru).

    Science.gov (United States)

    Rosas, Miluska; Vanacker, Veerle; Huggel, Christian; Gutierrez, Ronald R.

    2017-04-01

    Water erosion is one of the main environmental problems in Peru. The elevated rates of soil erosion are related to the rough topography of the Andes, shallow soils, highly erosive climate and the inappropriate land use management. Agricultural activities are directly affected by the elevated soil erosion rates, either through reduced crop production and/or damage to irrigation infrastructure. Similarly, the development of water infrastructure and hydropower facilities can be negatively affected by high sedimentation rates. However, critical information about sediment production, transport and deposition is still mostly lacking. This paper focuses on sediment dynamics in the context of land use and climate change in the Peruvian Andes. Within the Peruvian Coastal Range, the catchment of the Cañete River is studied as it plays an important role in the social and economic development of the region, and due to its provision of water and energy to rural and urban areas. The lower part of the basin is an arid desert, the middle sub-humid part sustains subsistence agriculture, and the upper part of the basin is a treeless high-elevation puna landscape. Snow cover and glaciers are present at its headwaters located above 5000 m asl. The retreat of glaciers due to climate change is expected to have an impact on water availability, and the production and mobilization of sediment within the river channels. Likewise, climate variability and land cover changes might trigger an important increase of erosion and sediment transport rates. The methodology applied to face this issue is principally based on the analysis of sediment samples recollected in the basin in the period 1998 to 2001, and the application of a water and sediment routing model. The paper presents new data on the sensitivity of water infrastructure and hydropower facilities to climate-induced changes in sediment mobilization.

  10. Nonconsecutive Pars Interarticularis Defects.

    Science.gov (United States)

    Elgafy, Hossein; Hart, Ryan C; Tanios, Mina

    2015-12-01

    Lumbar spondylolysis is a well-recognized condition occurring in adolescents because of repetitive overuse in sports. Nonconsecutive spondylolysis involving the lumbar spine is rare. In contrast to single-level pars defects that respond well to conservative treatment, there is no consensus about the management of multiple-level pars fractures; a few reports indicated that conservative management is successful, and the majority acknowledged that surgery is often required. The current study presents a rare case of pars fracture involving nonconsecutive segments and discusses the management options. In this case report, we review the patient's history, clinical examination, radiologic findings, and management, as well as the relevant literature. An 18-year-old man presented to the clinic with worsening lower back pain related to nonconsecutive pars fractures at L2 and L5. After 6 months of conservative management, diagnostic computed tomography-guided pars block was used to localize the symptomatic level at L2, which was treated surgically; the L5 asymptomatic pars fracture did not require surgery. At the last follow-up 2 years after surgery, the patient was playing baseball and basketball, and denied any back pain. This article reports a case of rare nonconsecutive pars fractures. Conservative management for at least 6 months is recommended. Successful management depends on the choice of appropriate treatment for each level. Single-photon emission computed tomography scan, and computed tomography-guided pars block are valuable preoperative tools to identify the symptomatic level in such a case.

  11. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events...... and outperforms traditional markers of inflammation such as C-reactive protein (CRP) in prognosticating a range of CVDs. Furthermore, of particular interest is the suggestion that suPAR reflects a pathophysiological pathway more closely linked with subclinical organ damage than CRP. We provide the first...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  12. NATO Glossary of Abbreviations Used in NATO Documents and Publications (glossaire otan des abreviations utilisees dans les documents et publications otan)

    Science.gov (United States)

    2010-01-01

    02] informatique [EAPC(NCSREPS)WP] Note : usage général et très courant. traitement automatique des données /TAD2/ [ADatP-02] ADP3 automatic... informatique [ADatP-02] ADR1 aerodrome damage repair [AAP-06] réparation des dégâts subis par un aérodrome [AAP-06] ADR2 air defence radar [NASG...AC/281-N(2009)0090] commandement, contrôle, communication et informatique [AC/281-N(2009)0090] CA1 civil affairs [C-M(2004)0001] affaires

  13. Preliminary study of the preparation of uranium 232 by irradiation of protactinium 231; Etude preliminaire a la preparation d'uranium 232 par irradiation de protactinium 231

    Energy Technology Data Exchange (ETDEWEB)

    Guillot, Ph. [Commissariat a l' Energie Atomique, Fontenay aux Roses (France). Centre d' Etudes Nucleaires

    1965-07-01

    A bibliography about preparation of uranium 232 is done. This even-even isotope of uranium is suitable for radioactive tracer, neutron source through {alpha},n reaction and heat source applications. The irradiation of protactinium 231, the chemical separation and the purification of uranium are studied. (author) [French] Une etude bibliographique de la preparation d'uranium 232 a ete effectuee. Cet isotope pair-pair de l'uranium peut etre utilise en tant que traceur, source d'energie et source de neutrons, lorsqu'il est melange a un element leger tel le beryllium. Une etude du taux de formation des isotopes produits, lors de l'irradiation du protactinium 231 - une des manieres d'obtenir l'uranium 232 - a ete faite a l'aide d'un programme passe sur ordinateur. Les problemes poses par la separation chimique et la purification de l'uranium ont ete egalement envisages dans ce rapport. (auteur)

  14. Evaluation de la qualite osseuse par les ondes guidees ultrasonores =

    Science.gov (United States)

    Abid, Alexandre

    La caracterisation des proprietes mecaniques de l'os cortical est un domaine d'interet pour la recherche orthopedique. En effet, cette caracterisation peut apporter des informations primordiales pour determiner le risque de fracture, la presence de microfractures ou encore depister l'osteoporose. Les deux principales techniques actuelles de caracterisation de ces proprietes sont le Dual-energy X-ray Absorptiometry (DXA) et le Quantitative Computed Tomogaphy (QCT). Ces techniques ne sont pas optimales et presentent certaines limites, ainsi l'efficacite du DXA est questionnee dans le milieu orthopedique tandis que le QCT necessite des niveaux de radiations problematiques pour en faire un outil de depistage. Les ondes guidees ultrasonores sont utilisees depuis de nombreuses annees pour detecter les fissures, la geometrie et les proprietes mecaniques de cylindres, tuyaux et autres structures dans des milieux industriels. De plus, leur utilisation est plus abordable que celle du DXA et n'engendrent pas de radiation ce qui les rendent prometteuses pour detecter les proprietes mecaniques des os. Depuis moins de dix ans, de nombreux laboratoires de recherche tentent de transposer ces techniques au monde medical, en propageant les ondes guidees ultrasonores dans les os. Le travail presente ici a pour but de demontrer le potentiel des ondes guidees ultrasonores pour determiner l'evolution des proprietes mecaniques de l'os cortical. Il commence par une introduction generale sur les ondes guidees ultrasonores et une revue de la litterature des differentes techniques relatives a l'utilisation des ondes guidees ultrasonores sur les os. L'article redige lors de ma maitrise est ensuite presente. L'objectif de cet article est d'exciter et de detecter certains modes des ondes guides presentant une sensibilite a la deterioration des proprietes mecaniques de l'os cortical. Ce travail est realise en modelisant par elements finis la propagation de ces ondes dans deux modeles osseux

  15. Improvements in electric power system of the effluent treatment station of the hot strip mill no. 2 (ETE/LTQ-2); Melhorias no sistema de alimentacao eletrica da estacao de tratamento de efluentes do laminador de tiras a quente n. 2 (ETE/LTQ-2)

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Hamilton Geraldo; Pinho, Wilson Pereira de; Martinez, Flavio Costa; Rocha, Carlos Eduardo da [Companhia Siderurgica Nacional (CSN), Volta Redonda, RJ (Brazil). Gerencia de Distribuicao de Energeticos

    2011-12-21

    The ETE/LTQ-2 is an vital area for the production process of coiled hot rolled strip. Any problems in the operating functions in this station results in the loss production in the mill. This is what occurred in 2007 January when there was problems in the termination of the power cables from the transformer of the circuit B-521 and in December in the same year, when there was an explosion of the oil cutout switch, which resulted in serious injury to the production process of the LTQ-2. Thus, began a search process for solutions to improve the reliability and security of the electrical system that meets the motor pumps of the ETE/LTQ-2 to reduce the risk of interference in the production process in result of the electrical faults. In 2010 June, was completed the implementations of the solutions to improve this performance, which consisted of repowering the two power circuits of the ETE/LTQ-2 (B-521 and B-570), replacement of the transformers for others of higher power (3.75 MVA to 5.5 MVA) of both circuits and replacement the oil cutout switch for SF6 circuit breakers. (author)

  16. Impact de la preparation des anodes crues et des conditions de cuisson sur la fissuration dans des anodes denses

    Science.gov (United States)

    Amrani, Salah

    La fabrication de l'aluminium est realisee dans une cellule d'electrolyse, et cette operation utilise des anodes en carbone. L'evaluation de la qualite de ces anodes reste indispensable avant leur utilisation. La presence des fissures dans les anodes provoque une perturbation du procede l'electrolyse et une diminution de sa performance. Ce projet a ete entrepris pour determiner l'impact des differents parametres de procedes de fabrication des anodes sur la fissuration des anodes denses. Ces parametres incluent ceux de la fabrication des anodes crues, des proprietes des matieres premieres et de la cuisson. Une recherche bibliographique a ete effectuee sur tous les aspects de la fissuration des anodes en carbone pour compiler les travaux anterieurs. Une methodologie detaillee a ete mise au point pour faciliter le deroulement des travaux et atteindre les objectifs vises. La majorite de ce document est reservee pour la discussion des resultats obtenus au laboratoire de l'UQAC et au niveau industriel. Concernant les etudes realisees a l'UQAC, une partie des travaux experimentaux est reservee a la recherche des differents mecanismes de fissuration dans les anodes denses utilisees dans l'industrie d'aluminium. L'approche etait d'abord basee sur la caracterisation qualitative du mecanisme de la fissuration en surface et en profondeur. Puis, une caracterisation quantitative a ete realisee pour la determination de la distribution de la largeur de la fissure sur toute sa longueur, ainsi que le pourcentage de sa surface par rapport a la surface totale de l'echantillon. Cette etude a ete realisee par le biais de la technique d'analyse d'image utilisee pour caracteriser la fissuration d'un echantillon d'anode cuite. L'analyse surfacique et en profondeur de cet echantillon a permis de voir clairement la formation des fissures sur une grande partie de la surface analysee. L'autre partie des travaux est basee sur la caracterisation des defauts dans des echantillons d'anodes crues

  17. It's quicker "Par Avignon"!

    CERN Document Server

    2005-01-01

    For a few years, the CERN Library has been receiving books from the University of Hanover sent via Avignon, at least that's what it says on the envelope. Such a detour would mean that parcels were travelling 720 km more than the distance separating Geneva and Hanover, which would be a very strange state of affairs. The explanation lies in a spelling mistake. The sender has been stamping parcels with a stamp that says "Par Avignon prioritaire" (first-class via Avignon) instead of "Par Avion prioritaire" (First Class Air Mail), a source of much amusement to the librarians!

  18. suPAR

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Giamarellos-Bourboulis, Evangelos J

    2015-01-01

    promising biomarker is soluble urokinase-type plasminogen activator receptor (suPAR). Three studies in large populations of critically ill patients and patients admitted to the emergency department have shown that concentrations >12ng/mL can safely predict unfavourable outcome. This review presents...

  19. Applications of electrical resistivity measurements to research into the purification of uranium using floating molten zone by electronic bombardment; Applications des mesures de resistivite electrique a l'etude de la purification de l'uranium par fusion de zone flottante par bombardement electronique

    Energy Technology Data Exchange (ETDEWEB)

    Pascal, J.L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-02-01

    The purification of uranium has been achieved by zone melting. Because of the high affinity of uranium towards elements such as oxygen, contamination has been avoided by adopting the floating zone technique and by working under high vacuum. The difficulties created by the deformations of uranium rod, which are caused by anisotropy of dilatation of phases {alpha} and {beta} and allotropic transformations {alpha} {r_reversible} {beta} and {beta} {r_reversible} {alpha}, have been overcome by the use of electron bombardment stabilized by feedback. A rough control of the purification was obtained by micrographic examination, microhardness measurements, and tests of secondary recrystallization, allowed us to appreciate the new degree of purity of the uranium obtained. The investigation of the purity degree was pursued by electrical resistivity measurements at 20 deg. K. But one had to take care in the interpretation of those measurements of the anisotropy of the uranium resistivity and the influence of structure on residual resistivity. Those measurements have led us, by determination of single crystal and uranium resistivity, to be able to distinguish between the principal resistivity against axis [100] and [010]. (author) [French] La purification de l'uranium a ete realisee par l'application de la methode dite de la zone fondue. L'uranium etant particulierement reactif vis-a-vis d'elements tels que l'oxygene, les risques de contamination ont ete supprimes en adoptant la technique de la zone flottante et en operant sous vide eleve. Les difficultes creees par les deformations du barreau d'uranium, dues a l'anisotropie de dilatation des phases {alpha} et {beta} et ou passage des deux points de transformation allotropiques {alpha} {r_reversible} {beta} et {beta} {r_reversible} {alpha}, ont pu etre surmontees par l'emploi du chauffage par bombardement electronique, stabilise par un systeme tres simple de contre reaction. Un premier

  20. Etude de la transition tribologique entre le fretting et le meso-fretting pour des materiaux de contact electrique

    Science.gov (United States)

    Gagnon, Daniel

    Dans les installations electriques, les contacts sont toujours soumis a des contraintes alternees ou a des micro-deplacements. Il en resulte une corrosion par fretting, phenomene defini comme un type de deterioration de la surface qui se produit lorsque deux materiaux en contact sont soumis a des mouvements microscopiques d'oscillations de tres faible amplitude (0 a 100 mum). Ceci a pour effet de provoquer une degradation de la resistance de contact et une interruption du passage du courant. Ce phenomene a des repercussions considerables sur le plan pratique puisque les micro-deplacements de pieces en contact peuvent etre causes par la dilatation thermique differentielle des metaux, par des vibrations mecaniques, par la relaxation des contraintes ou par l'echauffement des contacts lorsqu'on interrompt et retablit le courant. Nous avons donc dans le cadre de cette these etudie plusieurs aspects du fretting (0--100 mum) et du meso-fretting (100 a 1000 mum) pour differents materiaux de contact electrique. Des travaux experimentaux ont ete realises a partir de deux montages reproduisant divers aspects de la degradation par le fretting. Un premier montage de fretting de type bille-plaque a ete entierement developpe a l'ETS et un second montage, de type fil-plaque a ete utilise en collaboration avec Hydro Quebec IREQ a Varennes. Plusieurs techniques de mesures et d'analyse relevant tant du domaine de la mecanique du contact que de la metallurgie ont ete utilisees pour traiter les resultats. L'influence du courant sur le taux d'usure et la force de friction a ete examinee pour divers materiaux de contacts. Des essais de fatigue thermique et electrique ont ete realises sur divers materiaux et lubrifiants de contact. Il a ete demontre que pour le domaine entre 100 mum et 1000 mum, le taux d'usure n'est pas le meme de 0 a 100 mum et au dela de 1000 mum. La plupart des materiaux evalues montrent un stade de comportement intermediaire dont le debut se situe entre 100 mum et

  1. PAR Loop Schedule Review

    Energy Technology Data Exchange (ETDEWEB)

    Schaffer, Jr.; W.F.

    1958-04-30

    The schedule for the installation of the PAR slurry loop experiment in the South Facility of the ORR has been reviewed and revised. The design, fabrications and Installation is approximately two weeks behind schedule at this time due to many factors; however, indications are that this time can be made up. Design is estimated to be 75% complete, fabrication 32% complete and installation 12% complete.

  2. Modelling of the generation phase of an absorption cooling cycle operating intermittently; Modelisation de la phase generation d'un cycle de refrigeration par absorption solaire a fonctionnement intermittent

    Energy Technology Data Exchange (ETDEWEB)

    Boukhchana, Yasmina; Fellah, Ali; Ben Brahim, Ammar [Unite de Recherche, Thermodynamique Appliquee (99/UR/11-21), Universite de Gabes, Ecole Nationale d' ingenieurs, 6072 Gabes (Tunisia)

    2011-01-15

    No abstract prepared. [French] La modelisation en regime dynamique de la phase generation d'une installation frigorifique a absorption solaire a fonctionnement intermittent utilisant le couple ammoniac/eau a ete elaboree. L'etude basee sur l'intermittence du fonctionnement a permis d'elaborer, a travers les bilans matieres et thermiques, un modele thermodynamique reliant les temperatures, les debits et les fractions massiques dans les differents compartiments. Des journees ensoleillees representatives des quatre saisons de l'annee ont ete considerees. Les variations du taux d'ensoleillement, des temperatures et des concentrations ont ete explorees. Les resultats ont montre, moyennant les hypotheses adoptees en particulier a pression de fonctionnement constante, que la demarche proposee a permis d'avoir une temperature de generation autour de 135 C et une temperature de condensation de 60 C. Ces temperatures sont atteinte par l'adaptation de la convection naturelle a l'air pour le fonctionnement du condenseur. (orig.)

  3. Elimination of slightly radioactive liquid effluent by dilution. Its consequences (1960); Elimination par dilution d'effluents liquides faiblement radioactifs. Leurs consequences (1960)

    Energy Technology Data Exchange (ETDEWEB)

    Bovard, P.; Candillon, C. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    Nuclear centres often have to solve problems raised by the elimination of large volumes of slightly radioactive liquid effluent. As things stand at present, the method usually adopted consists in expelling this effluent into the main water system in order to dilute it to a maximum, and thus to lower its radioactive isotope concentration to below the norms imposed by the Public Health Service. This technique requires systematic checking of the water system and its dependences, and demands a thorough knowledge of adsorption and fixation processes. (author) [French] Les centres nucleaires ont frequemment a resoudre des problemes poses par l'elimination de volumes importants d'effluents liquides faiblement radioactifs. Dans l'etat actuel des choses, la solution la plus utilisee consiste a rejeter ces effluents dans le reseau hydrographique de maniere a les diluer au maximum et abaisser ainsi leurs teneurs en isotopes radioactifs au-dessous des normes imposees par la Sante Publique. Cette technique necessite un controle systematique du reseau et de ses dependances et demande une connaissance approfondie des processus d'adsorption et de fixation. (auteur)

  4. Automatic inspection of electron beam weld for stainless steel using phased array method; Controle automatique par ultrasons multielements de soudures inox realisees par faisceau d'electrons

    Energy Technology Data Exchange (ETDEWEB)

    Bleuze, A. [Metalscan - Groupe Tecnatom, 71100 Saint-Remy (France); Schwartz, C. [Commissariat a l' Energie Atomique, Centre de Valduc - 21120 Is-Sur-Tille - (France)

    2007-07-01

    en partenariat avec la societe METALSCAN une technique d'imagerie ultrasonore multielements dediee au controle complet et automatique de soudures homogenes d'aciers Inox realisees par faisceau d'electrons. Pour atteindre cet objectif, une etude acoustique par simulation avec le logiciel CIVA a ete menee afin de determiner les caracteristiques optimales des sondes multielements (leur nombre et leur emplacement). Au final, la methode developpee permet, d'une part, de localiser des manques de fusion de soudure equivalents a des trous a fond plats de 0,5 mm de diametre, et d'autre part, de detecter des manques de penetration de 0,1 mm. Afin d'assurer une parfaite reproductibilite des controles, un systeme mecanique assurant la mise en rotation de la piece, permet d'inspecter l'ensemble de la soudure. Les resultats sont alors analyses automatiquement a l'aide d'un logiciel specifique assurant la tracabilite des controles. La methode a tout d'abord ete validee a l'aide de pieces etalons, puis elle a ete mise en service apres confrontation des resultats obtenus sur des defauts reels avec d'autres techniques (radiographie et caracterisations metallographiques). (auteurs)

  5. Parálisis cerebral :

    OpenAIRE

    Aguado Navarro, Ana Belén

    2013-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  6. Brulures par Diluant

    Science.gov (United States)

    Benbrahim, A.; Jerrah, H.; Diouri, M.; Bahechar, N.; Boukind, E.H.

    2009-01-01

    Summary La flamme de diluant est une cause non rare de brûlure dans le contexte marocain. Nous avons jugé intéressant de faire une étude épidémiologique sur la brûlure par flamme de diluant (BFD) au centre national des brûlés (CNB) du CHU Ibn-Rochd de Casablanca. Ce travail a été réalisé sur une période de 10 mois (septembre 2007/juin 2008). Le but du travail est de montrer les caractéristiques de ce type de brûlures pour les prévenir et ce par l'information sur le diluant, produit causant ces brûlures, et ses différents dangers, la brûlure notamment. Durant cette période, nous avons colligé 17 cas de BFD sur un total de 356 patients admis au CNB pour brûlures aiguës toute étiologie confondue. La moyenne d'age des patients concernés est de 32 ans. Ils sont presque tous de sexe masculin (16 hommes/1 femme) et ont des antécédents de toxicomanie et/ou de délinquance. Tous nos patients sont de bas niveau socio-économique et habitent dans des bidonvilles pour la plupart. La brûlure est souvent secondaire à une agression dans la rue (92% des cas). Concernant les caractéristiques de la brûlure, la surface cutanée brûlée moyenne est de 23%; elle est souvent profonde et siège surtout au niveau des membres supérieurs et du tronc. PMID:21991179

  7. Prevalencia de hongos en harina de Lepidium peruvianum «Maca» en mercados de Andahuaylas, Ica y Cañete - Perú

    Directory of Open Access Journals (Sweden)

    Alfonso Orellana

    2013-05-01

    Full Text Available Se determinó la prevalencia de hongos en la harina de Lepidium peruvianum «maca» en un total de 60 muestras procedentes de los mercados de Andahuaylas (20, Ica (20 y Cañete (20. Las muestras fueron procesadas mediante el método de diluciones sucesivas y sembradas en superficie en Agar Papa Dextrosa (APD. El 96,7% del total de muestras estaban contaminadas; identificándose 9 géneros y un total de 14 especies de mohos filamentosos, incluyendo uno clasificado como Mycelia sterilia. El recuento general de colonias va desde 33x104 a 61x104 UFC/g., no existiendo diferencia significativa entre los centros de expendio. Los géneros con mayor incidencia fueron Penicillium y Fusarium. La alta prevalencia de hongos contaminantes en la harina de maca sugieren continuar estudios destinados a evaluar el efecto y riesgo sanitario que representa su consumo para la salud humana.

  8. Insights into ParB spreading from the complex structure of Spo0J and parS.

    Science.gov (United States)

    Chen, Bo-Wei; Lin, Ming-Hsing; Chu, Chen-Hsi; Hsu, Chia-En; Sun, Yuh-Ju

    2015-05-26

    Spo0J (stage 0 sporulation protein J, a member of the ParB superfamily) is an essential component of the ParABS (partition system of ParA, ParB, and parS)-related bacterial chromosome segregation system. ParB (partition protein B) and its regulatory protein, ParA, act cooperatively through parS (partition S) DNA to facilitate chromosome segregation. ParB binds to chromosomal DNA at specific parS sites as well as the neighboring nonspecific DNA sites. Various ParB molecules can associate together and spread along the chromosomal DNA. ParB oligomer and parS DNA interact together to form a high-order nucleoprotein that is required for the loading of the structural maintenance of chromosomes proteins onto the chromosome for chromosomal DNA condensation. In this report, we characterized the binding of parS and Spo0J from Helicobacter pylori (HpSpo0J) and solved the crystal structure of the C-terminal domain truncated protein (Ct-HpSpo0J)-parS complex. Ct-HpSpo0J folds into an elongated structure that includes a flexible N-terminal domain for protein-protein interaction and a conserved DNA-binding domain for parS binding. Two Ct-HpSpo0J molecules bind with one parS. Ct-HpSpo0J interacts vertically and horizontally with its neighbors through the N-terminal domain to form an oligomer. These adjacent and transverse interactions are accomplished via a highly conserved arginine patch: RRLR. These interactions might be needed for molecular assembly of a high-order nucleoprotein complex and for ParB spreading. A structural model for ParB spreading and chromosomal DNA condensation that lead to chromosome segregation is proposed.

  9. Spectrographic determination of chlorine and fluorine; Dosage du chlore et du fluor par spectrographie d'emission en atmosphere inerte

    Energy Technology Data Exchange (ETDEWEB)

    Contamin, G. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1965-04-01

    Experimental conditions have been investigated in order to obtain the highest sensitivity in spectrographic determination of chlorine and fluorine using the Fassel method of excitation in an inert atmosphere. The influence of the nature of the atmosphere, of the discharge conditions and of the matrix material has been investigated. The following results have been established: 1. chlorine determination is definitely possible: a working curve has been drawn between 10 {mu}g and 100 {mu}g, the detection limit being around 5 {mu}g; 2. fluorine determination is not satisfactory: the detection limit is still of the order of 80 {mu}g. The best operating conditions have been defined for both elements. (author) [French] Nous avons recherche quelles etaient les conditions permettant d'obtenir la meilleure sensibilite dans le dosage spectrographique du chlore et du fluor par la methode d'excitation en atmosphere inerte (methode de Fassel). Nous avons etudie l'influence de l'atmosphere gazeuse, des conditions de la decharge et du materiau de pastillage. Les points suivants ont ete etablis: 1. le dosage du chlore est possible: une courbe de dosage a ete tracee entre 10 {mu}g et 100 {mu}g et la limite de detection est de l'ordre de 5 {mu}g; 2. le dosage du fluor n'est pas satisfaisant: la limite de detection obtenue etant encore de l'ordre de 80 {mu}g. Les conditions operatoires ont ete precisees pour ces deux elements. (auteur)

  10. Datation par thermoluminescence

    Directory of Open Access Journals (Sweden)

    1976-01-01

    Full Text Available Depuis 1953, de nombreux chercheurs se sont intéressés à la datation par thermoluminescence de minéraux anciennement brûlés ou cuits. Dans ce travail, après avoir rappelé quelques principes physiques de la thermoluminescence, on présente cette méthode de datation en mettant l'accent sur le mécanisme thermoluminescent dans une poterie. Ainsi la dose d'irradiation reçue par le matériau étant proportionnelle au temps écoulé depuis le 'zéro archéologique', il est possible de déterminer 'la dose archéologique' et d'en déduire l'âge de l'échantillon après avoir calculé la dose d'irradiation annuelle. La réalisation pratique d'un tel ensemble de mesure est cependant très ardue. Dans un prochain article, E. A. Decamps et A. Roman montreront des résultats relatifs à la thermoluminescence d'échantillons de quartz naturels, purs et dopés et la mise au point d'une nouvelle méthode de datation. Desde 1953, muchos investigadores se han interesado en la datación por termoluminiscencia de minerales antiguamente quemados o cocidos. Dentro de este trabajo, luego de haber recordado algunos principios físicos de la termoluminiscencia, se presenta este método de datación poniendo mayor atención en el mecanismo termoluminescente en una vasija de metal o de barro. Siendo proporcional la dosis de irradiación recibida al tiempo transcurrido desde el 'cero arqueológico', es posible determinar 'la dosis arqueológica', y deducir la edad de la muestra luego de haber calculado la dosis de irradiación anual. La realización práctica de un trabajo de tal dimensión es sin embargo muy ardua. En un próximo artículo, E. A. Decamps y A. Román presentarán los resultados relativos a la termoluminiscencia de muestras de cuarzo naturales, puras y dopadas y la elaboración de un nuevo método de datación. Since 1953, a number of scientists have been concerned with the use of thermoluminescence for the dating of burned or fired minerals

  11. Elusloom lennukiga puhkusele / Inge Parring

    Index Scriptorium Estoniae

    Parring, Inge

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 1. okt. lk. 13. Air Cargo Estonia/ACE Logisticsi müügijuht Inge Parring tutvustab elusloomade transpordivõimalusi. Vt. samas: Loomade transportimiseks vajalikud dokumendid

  12. Some techniques for studying actomyosin by electron microscopy; Quelques techniques d'etude de l'actomyosine par microscopie electronique

    Energy Technology Data Exchange (ETDEWEB)

    Herzberg, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires. Departement de Biologie

    1967-07-01

    A method has been developed for shadowing using a platinum-carbon alloy; it has been applied to the study of the interaction of actomyosin with its substrate ATP. The results obtained seem to favour the hypothesis of a dissociation of the actomyosin into its two components: actin and myosin. Pictures have been obtained showing particles resembling non-polymerized myosin but no rigorous proof of this exists. (author) [French] Une methode d'ombrage par un alliage de platine et carbone a ete mise au point et appliquee a l'etude de l'interaction de l'actomyosine et de son substrat l'ATP. Les resultats obtenus semblent pencher en faveur de la these d'une dissociation de l'actomyosine en ses deux constituants: l'actine et la myosine. Des images ont ete obtenues montrant des particules dont l'identite avec la myosine non polymerisee reste a demontrer plus rigoureusement. (auteur)

  13. Fabrication de memoire monoelectronique non volatile par une approche de nanogrille flottante

    Science.gov (United States)

    Guilmain, Marc

    Les transistors monoelectroniques (SET) sont des dispositifs de tailles nanometriques qui permettent la commande d'un electron a la fois et donc, qui consomment peu d'energie. Une des applications complementaires des SET qui attire l'attention est son utilisation dans des circuits de memoire. Une memoire monoelectronique (SEM) non volatile a le potentiel d'operer a des frequences de l'ordre des gigahertz ce qui lui permettrait de remplacer en meme temps les memoires mortes de type FLASH et les memoires vives de type DRAM. Une puce SEM permettrait donc ultimement la reunification des deux grands types de memoire au sein des ordinateurs. Cette these porte sur la fabrication de memoires monoelectroniques non volatiles. Le procede de fabrication propose repose sur le procede nanodamascene developpe par C. Dubuc et al. a 1'Universite de Sherbrooke. L'un des avantages de ce procede est sa compatibilite avec le back-end-of-line (BEOL) des circuits CMOS. Ce procede a le potentiel de fabriquer plusieurs couches de circuits memoirestres denses au-dessus de tranches CMOS. Ce document presente, entre autres, la realisation d'un simulateur de memoires monoelectroniques ainsi que les resultats de simulations de differentes structures. L'optimisation du procede de fabrication de dispositifs monoelectroniques et la realisation de differentes architectures de SEM simples sont traitees. Les optimisations ont ete faites a plusieurs niveaux : l'electrolithographie, la gravure de l'oxyde, le soulevement du titane, la metallisation et la planarisation CMP. La caracterisation electrique a permis d'etudier en profondeur les dispositifs formes de jonction de Ti/TiO2 et elle a demontre que ces materiaux ne sont pas appropries. Par contre, un SET forme de jonction de TiN/Al2O3 a ete fabrique et caracterise avec succes a basse temperature. Cette demonstration demontre le potentiel du procede de fabrication et de la deposition de couche atomique (ALD) pour la fabrication de memoires

  14. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. ...... in inflammation and pathogenic processes. We focus on the molecular mechanisms of the suPAR fragments and the link to the inflammatory process,as this could lead to medical applications in infectious and pathological conditions........ Studies suggest that full-length suPAR is a regulator of uPAR/uPA by actingas uPA-scavenger, whereas the cleaved suPAR(II-III) act as a chemotactic agent promoting the immune response via the SRSRY sequence in the linker-region. This review focus on the various suPAR fragments and their involvement...

  15. Immunopathogenic Background of Pars Planitis.

    Science.gov (United States)

    Przeździecka-Dołyk, Joanna; Węgrzyn, Agnieszka; Turno-Kręcicka, Anna; Misiuk-Hojło, Marta

    2016-04-01

    Pars planitis is defined as an intermediate uveitis of unknown background of systemic disease with characteristic formations such as vitreous snowballs, snowbanks and changes in peripheral retina. The incidence of pars planitis varies 2.4-15.4 % of the uveitis patients. The pathogenesis of the disease is to be determined in future. Clinical and histopathological findings suggest an autoimmune etiology, most likely as a reaction to endogenous antigen of unknown source, with T cells predominant in both vitreous and pars plana infiltrations. T cells subsets play an important role as a memory-effector peripheral cell. Snowbanks are formed as an effect of post inflammatory glial proliferation of fibrous astrocytes. There is also a genetic predisposition for pars planitis by human leukocyte antigen and several other genes. A coexistence of multiple sclerosis and optic neuritis has been described in numerous studies. Epiretinal membrane, cataract, cystoid macular edema, retinal detachment, retinal vasculitis, neovascularization, vitreous peripheral traction, peripheral hole formation, vitreous hemorrhage, disc edema are common complications observed in pars planitis. There is a need to expand the knowledge of the pathogenic and immunologic background of the pars planitis to create an accurate pharmacological treatment.

  16. Electronic temperature measurement on the deca II plasma using the Bremsstrahlung; Mesure de la temperature electronique du plasma de deca II par etude du rayonnement de freinage

    Energy Technology Data Exchange (ETDEWEB)

    Dumas, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-06-01

    The electronic temperature of the DECA II machine's plasma is determined by studying the Bremsstrahlung. Two types of detectors are used for this measurement, a set scintillator-photo-multiplicator and a photoelectric effect detector with a massive silver target. The method used is the classical 'absorbent method', The absorbents used are thin formvar foils whose thickness is between 600 and 12 500 angstrom. The measurements done in two different working conditions of the DECA II machine have given: Te {approx_equal} 200 eV in the first case and Te {approx_equal} 70 eV in the second case. (author) [French] Nous avons determine la temperature electronique du plasma de la machine DECA II par l'etude du rayonnement de freinage. Pour cette mesure nous avons utilise deux types de detecteurs: des ensembles scintillateur-photomultiplicateur et un detecteur a effet photoelectrique a cible massive en argent. La methode utilisee pour cette mesure est la classique methode des absorbants. Nous avons utilise des feuilles de format tres mince (de 600 a 12 500 angstrom) comme absorbant. Les mesures faites dans deux regimes de travail differents de la machine DECA II nous ont conduit a: Te {approx_equal} 200 eV dans un cas et Te {approx_equal} eV dans l'autre cas. (auteur)

  17. Etude de la performance des radars hautes-frequences CODAR et WERA pour la mesure des courants marins en presence partielle de glace de mer

    Science.gov (United States)

    Kamli, Emna

    Les radars hautes-frequences (RHF) mesurent les courants marins de surface avec une portee pouvant atteindre 200 kilometres et une resolution de l'ordre du kilometre. Cette etude a pour but de caracteriser la performance des RHF, en terme de couverture spatiale, pour la mesure des courants de surface en presence partielle de glace de mer. Pour ce faire, les mesures des courants de deux radars de type CODAR sur la rive sud de l'estuaire maritime du Saint-Laurent, et d'un radar de type WERA sur la rive nord, prises pendant l'hiver 2013, ont ete utilisees. Dans un premier temps, l'aire moyenne journaliere de la zone ou les courants sont mesures par chaque radar a ete comparee a l'energie des vagues de Bragg calculee a partir des donnees brutes d'acceleration fournies par une bouee mouillee dans la zone couverte par les radars. La couverture des CODARs est dependante de la densite d'energie de Bragg, alors que la couverture du WERA y est pratiquement insensible. Un modele de fetch appele GENER a ete force par la vitesse du vent predite par le modele GEM d'Environnement Canada pour estimer la hauteur significative ainsi que la periode modale des vagues. A partir de ces parametres, la densite d'energie des vagues de Bragg a ete evaluee pendant l'hiver a l'aide du spectre theorique de Bretschneider. Ces resultats permettent d'etablir la couverture normale de chaque radar en absence de glace de mer. La concentration de glace de mer, predite par le systeme canadien operationnel de prevision glace-ocean, a ete moyennee sur les differents fetchs du vent selon la direction moyenne journaliere des vagues predites par GENER. Dans un deuxieme temps, la relation entre le ratio des couvertures journalieres obtenues pendant l'hiver 2013 et des couvertures normales de chaque radar d'une part, et la concentration moyenne journaliere de glace de mer d'autre part, a ete etablie. Le ratio des couvertures decroit avec l'augmentation de la concentration de glace de mer pour les deux types

  18. Contribution to the study of proton elastic and inelastic scattering on {sup 12}C; Contribution a l'etude des diffusions elastiques et inelastiques des protons sur le carbone 12

    Energy Technology Data Exchange (ETDEWEB)

    Sadeghi, A

    1966-07-01

    The results of absolute measurements of cross sections for the scattering of protons by {sup 12}C to the two first excited levels are given. The measurements were made from 4.6 to 11.4 MeV at 17 angles for (p,p) and at 15 angles for (p,p') (1. excited level) as well as 8 angles for (p,p'') (2. excited level). A gaseous target with differential pumping was used. The elastic scattering was analyzed using the R-matrix theory with the optical model. Then a new analysis of both (p,p) and (p,p') was achieved using the coupled-wave formalism. The information on the levels of the compound nucleus was completed and was confirmed. (author) [French] Cette these rapporte le resultat de mesures absolues des sections efficaces de diffusion p,p et pp' (conduisant aux deux premiers niveaux excites) de protons par '1'2C. Ces mesures ont ete faites de 4,6 a 11,4 MeV, a 17 angles pour (p,p), a 15 angles pour pp' (1er niveau excite) et a 8 angles pour pp'' (2eme niveau excite). Une chambre a cible gazeuse avec pompage differentiel a ete utilisee. La diffusion elastique a ete analysee au moyen de la theorie de la matrice R avec modele optique pour (p,p). Cette analyse a ete reprise en meme temps que celle de la diffusion inelastique par l'emploi d'equations couplees. Les resultats anterieurs sur les niveaux du noyau compose ont ete confirmes et completes. (auteur)

  19. Extraction of beryllium sulfate by a long chain amine; Extraction du sulfate de beryllium par une amine a longue chaine

    Energy Technology Data Exchange (ETDEWEB)

    Etaix, E.S. [Commissariat a l' Energie Atomique, Fontenay-Aux-Roses (France). Centre d' Etudes Nucleaires

    1968-06-01

    The extraction of sulfuric acid in aqueous solution by a primary amine in benzene solution, 3-9 (diethyl) - 6-amino tri-decane (D.E.T. ) - i.e., with American nomenclature 1-3 (ethyl-pentyl) - 4-ethyl-octyl amine (E.P.O.) - has made it possible to calculate the formation constants of alkyl-ammonium sulfate and acid sulfate. The formula of the beryllium and alkyl-ammonium sulfate complex formed in benzene has next been determined, for various initial acidity of the aqueous solution. Lastly, evidence has been given of negatively charged complexes of beryllium and sulfate in aqueous solution, through the dependence of the aqueous sulfate ions concentration upon beryllium extraction. The formation constant of these anionic complexes has been evaluated. (author) [French] L'etude de l'extraction de l'acide sulfurique en solution aqueuse par une amine primaire en solution dans le benzene, le diethyl-3,9 amino-6 tridecane (D.E.T.) - autre nom americain 1-3 (ethylpentyl) - 4-ethyloctylamine (E.P.O.) a permis de calculer les constantes de formation du sulfate et de l'hydrogenosulfate d'alkyl-ammonium. La formule du complexe de sulfate de beryllium et d'alkyl-ammonium forme en solution benzenique a ete ensuite determinee pour diverses acidites initiales de la solution aqueuse. Enfin, l'influence de la concentration des ions sulfate de la phase aqueuse sur l'extraction du beryllium a mis en evidence la formation en solution aqueuse de complexes anioniques de sulfate et de beryllium dont la constante de formation a ete evaluee. (auteur)

  20. The study of some thiazinic and indaminic dye syntheses induced by ionising radiation; Etude de quelques syntheses de colorants thianziniques et indaminiques amorcees par les rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Balestic, S. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-03-15

    With a view to finding some radiochemical reactions applicable on an industrial scale for evaluating the radioactive waste from nuclear reactors, a systematic study was made of the radiochemical synthesis of thiazinic dyes such as methylene blue and Lauths' violet, on which the first tests were carried out in 1954. The first part of the study concerned the identification and the dosage, during radiolysis, of dyes by means of their absorption spectra after separation from the reaction medium by adsorption chromatography or ion-exchange; other radiolysis products such as ammonium chloride and hydrogen peroxide were also identified. During a later stage by systematically varying the physico-chemical parameters it was possible to determine the most favourable conditions for radio-synthesis; the maximum radiochemical yields obtained had the following values: G (Lauths' violet) 1,65; G (Methylene blue) = 1,75. Furthermore, the study of the influence of variously substituted aminated products on the radiochemical yield showed the possibility of synthesising Bindsehedlers green and Wursters blue by radiochemical methods. Finally the discovery of a fundamental intermediate product, Wursters red, together with the kinetic study of the chemical synthesis of methylene blue made it possible to determine the main stages of the reaction mechanism and to decide which of these stages could be attributed to ionising radiations in the case of the radiochemical synthesis. (author) [French] Dans le but de trouver des reactions radiochimiques susceptibles d'une application industrielle pour valoriser les dechets radioactifs provenant des reacteurs nucleaires, il a ete entrepris une etude systematique de la synthese radiochimique des colorants thiazimiques tels que le Bleu de Methylene et le Violet de Lauth dont les premiers essais ont ete effectues par Loiseleur en 1954. La premiere partie de l'etude a porte sur l'identification et le dosage des colorants formes

  1. Designing Tone Reservation PAR Reduction

    Directory of Open Access Journals (Sweden)

    Johansson Albin

    2006-01-01

    Full Text Available Tone reservation peak-to-average (PAR ratio reduction is an established area when it comes to bringing down signal peaks in multicarrier (DMT or OFDM systems. When designing such a system, some questions often arise about PAR reduction. Is it worth the effort? How much can it give? How much does it give depending on the parameter choices? With this paper, we attempt to answer these questions without resolving to extensive simulations for every system and every parameter choice. From a specification of the allowed spectrum, for instance prescribed by a standard, including a PSD-mask and a number of tones, we analytically predict achievable PAR levels, and thus implicitly suggest parameter choices. We use the ADSL2 and ADSL2+ systems as design examples.

  2. USO DE FUENTES NO CONVENCIONALES DE NITRÓGENO EN LA FERTILIZACIÓN DEL MAÍZ (Zea mays L.), EN CAÑETE (PERÚ). I: RENDIMIENTO Y EXTRACCIÓN DE N, P Y K

    OpenAIRE

    Aguirre Yato, Guillermo; Departamento Académico de Suelos. Facultad de Agronomía. Universidad Nacional Agraria La Molina. Av. La Molina S/N, La Molina Lima Perú.; Alegre Orihuela, Julio; Departamento Académico de Suelos. Facultad de Agronomía. Universidad Nacional Agraria La Molina. Av. La Molina S/N, La Molina Lima Perú.

    2015-01-01

    La industria cárnica y pesquera produce diversos residuos, que pueden ser usados en la agricultura. Para comparar el uso de harina de cuernos y pezuñas (HCP), y de residuos hidrolizados (RH) de la industria pesquera, con la fertilización mineral, se desarrolló un experimento de campo en el valle de Cañete (Perú), en el cultivo de maíz. Se cuantificaron la producción total de biomasa, el rendimiento de grano y el índice de cosecha (IC), encontrándose diferencias significativas entre tratamient...

  3. Increased ParB level affects expression of stress response, adaptation and virulence operons and potentiates repression of promoters adjacent to the high affinity binding sites parS3 and parS4 in Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Adam Kawalek

    Full Text Available Similarly to its homologs in other bacteria, Pseudomonas aeruginosa partitioning protein ParB facilitates segregation of newly replicated chromosomes. Lack of ParB is not lethal but results in increased frequency of anucleate cells production, longer division time, cell elongation, altered colony morphology and defective swarming and swimming motility. Unlike in other bacteria, inactivation of parB leads to major changes of the transcriptome, suggesting that, directly or indirectly, ParB plays a role in regulation of gene expression in this organism. ParB overproduction affects growth rate, cell division and motility in a similar way as ParB deficiency. To identify primary ParB targets, here we analysed the impact of a slight increase in ParB level on P. aeruginosa transcriptome. ParB excess, which does not cause changes in growth rate and chromosome segregation, significantly alters the expression of 176 loci. Most notably, the mRNA level of genes adjacent to high affinity ParB binding sites parS1-4 close to oriC is reduced. Conversely, in cells lacking either parB or functional parS sequences the orfs adjacent to parS3 and parS4 are upregulated, indicating that direct ParB- parS3/parS4 interactions repress the transcription in this region. In addition, increased ParB level brings about repression or activation of numerous genes including several transcriptional regulators involved in SOS response, virulence and adaptation. Overall, our data support the role of partitioning protein ParB as a transcriptional regulator in Pseudomonas aeruginosa.

  4. A study on the isotope effects in the reduction of carbon dioxide by zinc; Etude des effets isotopiques dans la reduction du gaz carbonique par le zinc

    Energy Technology Data Exchange (ETDEWEB)

    Senegacnik, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1957-06-15

    We have determined the isotope effects which occur in the reduction of carbon dioxide by zinc. It has been shown that in the case of irreversible surface reactions, Bernstein's equation which permits the calculation of the fractionation factor is still valid. These experimental factors are in good agreement with those obtained by calculating the partition functions of the adsorbed activated complexes. In the reaction mechanism used, the model of the activated complex corresponds to the dissociation of one of the carbon oxygen bonds CO{sub 2} {yields} CO + O. Perturbations arising from the slight reversibility of the reaction Zn + CO{sub 2} {r_reversible} ZnO + CO on the isotope effects on the carbon and oxygen atoms have also been calculated. (author) [French] Nous avons etudie les effets isotopiques qui ont lieu dans la reduction du gaz carbonique par le zinc. La validite de l'equation de Bernstein qui permet de calculer le facteur de fractionnement a ete demontree pour le cas d'une reaction irreversible de surface. Ces facteurs de fractionnement experimentaux sont en bon accord avec ceux obtenus par le calcul des fonctions de partition isotopiques des complexes actives adsorbes. Dans le mecanisme de reaction utilise, le modele du complexe active correspond a la dissociation d'une des liaisons carbone oxygene CO{sub 2} {yields} CO + O. Les effets perturbateurs de la reversibilite de la reduction Zn + CO{sub 2} {r_reversible} ZnO + CO sur les effets isotopiques du carbone et ceux de l'oxygene ont ete egalement evalues. (auteur)

  5. Mechanism of the extraction of nitric acid and water by organic solutions of tertiary alkyl-amines; Mecanisme d'extraction de l'acide nitrique et de l'eau par les solutions organiques d'alcoylamines tertiaires

    Energy Technology Data Exchange (ETDEWEB)

    Gourisse, D

    1966-06-01

    The micellar aggregation of tri-alkyl-ammonium nitrates in low polarity organic solvents has been verified by viscosity, conductivity and sedimentation velocity measurements. The aggregation depends upon the polarity of solvent, the length of the alkyl radicals and the organic concentration of the various constituents (tri-alkyl-ammonium nitrate, tri-alkyl-amine, nitric acid, water). The amine salification law has been established and the excess nitric acid and water solubilities in the organic solutions have been measured. Nitric acid and water are slightly more soluble in micellar organic solutions than in molecular organic solutions. A description of excess nitric acid containing tri-alkyl-ammonium nitrate solutions is proposed. (author) [French] Mecanisme d'extraction de l'acide nitrique et de l'eau par les solutions organiques d'alcoylamines tertiaires. L'agregation micellaire des nitrates de trialcoylammonium dans les solvants peu polaires a ete verifiee par viscosimetrie, conductimetrie et ultracentrifugation des solutions organiques. L'agregation depend de la polarite du solvant, de la longueur des radicaux alcoyle, et des concentrations des differents constituants de la solution organique (nitrate de trialcoylammonium, alcoylamine tertiaire, acide nitrique, eau). La loi de salification de l'amine a ete determinee et les solubilites de l'acide nitrique en exces et de l'eau dans les solutions organiques ont ete mesurees. L'acide nitrique et l'eau sont legerement plus solubles dans les organiques micellaires que dans les solutions organiques moleculaires. Une description des solutions de nitrate de trialcoylammonium contenant de l'acide nitrique en exces est proposee. (auteur)

  6. Restauration adaptative des contours par une approche inspiree de la prediction des performances

    Science.gov (United States)

    Rousseau, Kami

    En teledetection, les cartes de contours peuvent servir, entre autres choses, a la restitution geometrique, a la recherche d'elements lineaires, ainsi qu'a la segmentation. La creation de ces cartes est faite relativement tot dans la chaine de traitements d'une image. Pour assurer la qualite des operations subsequentes, il faut veiller a obtenir une carte de contours precise. Notre problematique est de savoir s'il est possible de diminuer la perte de temps liee au choix d'algorithme et de parametre en corrigeant automatiquement la carte de contours. Nous concentrerons donc nos efforts sur le developpement d'une methode de detection/restauration de contours adaptative. Notre methode s'inspire d'une technique de prediction des performances d'algorithmes de bas niveau. Elle consiste a integrer un traitement par reseau de neurones a une methode " classique " de detection de contours. Plus precisement, nous proposons de combiner la carte de performances avec la carte de gradient pour permettre des decisions plus exactes. La presente etude a permis de developper un logiciel comprenant un reseau de neurones entraine pour predire la presence de contours. Ce reseau de neurones permet d'ameliorer les decisions de detecteurs de contours, en reduisant le nombre de pixels de fausses alarmes et de contours manques. La premiere etape de ce travail consiste en une methode d'evaluation de performance pour les cartes de contours. Une fois ce choix effectue, il devient possible de comparer les cartes entre elles. Il est donc plus aise de determiner, pour chaque image, la meilleure detection de contours. La revue de la litterature realisee simultanement a permis de faire un choix d'un groupe d'indicateurs prometteurs pour la restauration de contours. Ces derniers ont servi a la calibration et a l'entrainement d'un reseau de neurones pour modeliser les contours. Par la suite, l'information fournie par ce reseau a ete combinee par multiplication arithmetique avec les cartes d

  7. PAR-1 and PAR-2 Expression Is Enhanced in Inflamed Odontoblast Cells.

    Science.gov (United States)

    Alvarez, M M P; Moura, G E; Machado, M F M; Viana, G M; de Souza Costa, C A; Tjäderhane, L; Nader, H B; Tersariol, I L S; Nascimento, F D

    2017-12-01

    Protease-activated receptors (PARs) are G protein-coupled receptors, which are activated by proteolytical cleavage of the amino-terminus and act as sensors for extracellular proteases. We hypothesized that PAR-1 and PAR-2 can be modulated by inflammatory stimulus in human dental pulp cells. PAR-1 and PAR-2 gene expression in human pulp tissue and MDPC-23 cells were analyzed by quantitative polymerase chain reaction. Monoclonal PAR-1 and PAR-2 antibodies were used to investigate the cellular expression of these receptors using Western blot, flow cytometry, and confocal microscopy in MDPC-23 cells. Immunofluorescence assays of human intact and carious teeth were performed to assess the presence of PAR-1 and PAR-2 in the dentin-pulp complex. The results show for the first time that human odontoblasts and MDPC-23 cells constitutively express PAR-1 and PAR-2. PAR-2 activation increased significantly the messenger RNA expression of matrix metalloproteinase (MMP)-2, MMP-9, MMP-13, and MMP-14 in MDPC-23 cells ( P < 0.05), while the expression of these enzymes decreased significantly in the PAR-1 agonist group ( P < 0.05). The high-performance liquid chromatography and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry analysis showed the presence of MMP-13 activity cleaving PAR-1 at specific, noncanonical site TLDPRS42↓F43LL in human dental pulp tissues. Also, we detected a presence of a trypsin-like activity cleaving PAR-2 at canonical site SKGR20↓S21LIGRL in pulp tissues. Confocal microscopy analysis of human dentin-pulp complex showed intense positive staining of PAR-1 and PAR-2 in the odontoblast processes in dentinal tubules of carious teeth compared to intact ones. The present results support the hypothesis of activation of the upregulated PAR-1 and PAR-2 by endogenous proteases abundant during the inflammatory response in dentin-pulp complex.

  8. Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-01-01

    Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

  9. Electron spin resonance and E.N.D.O.R. double resonance study of free radicals produced by gamma irradiation of imidazole single crystals; Etude par resonance paramagnetique electronique et double resonance E.N.D.O.R. des radicaux libres crees par irradiation gamma de monocristaux d'imidazole

    Energy Technology Data Exchange (ETDEWEB)

    Lamotte, B. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1970-07-01

    Gamma irradiation of imidazole single crystals at 300 deg. K gives two radicals. Identification and detailed studies of their electronic and geometric structure have been made by ESR and ENDOR techniques. A study of the hydrogen bonded protons hyperfine tensor is made and let us conclude to the inexistence of movement and tunneling of these protons. The principal low temperature radical, produced by gamma irradiation at 77 deg. K has been also studied by ESR and a model has been proposed. (author) [French] L'irradiation gamma de monocristaux d'imidazole a 300 deg. K conduit a deux radicaux dont l'identification et l'etude detaillee des structures electroniques et geometriques ont ete obtenues par la resonance paramagnetique electronique (RPE) et la double resonance ENDOR. En particulier l'examen des protons de la liaison hydrogene permet de conclure, pour ceux-ci, a l'inexistence de tout mouvement par effet tunnel. De plus, l'analyse des spectres de RPE du radical principal cree par irradiation gamma de l'imidazole a 77 deg. K nous a permis de proposer un modele pour ce radical. (auteur)

  10. Differences in clinical characteristics of fallopian canal dehiscence associated with pars flaccida and pars tensa cholesteatomas.

    Science.gov (United States)

    Shinnabe, Akihiro; Yamamoto, Hiroki; Hara, Mariko; Hasegawa, Masayo; Matsuzawa, Shingo; Kanazawa, Hiromi; Yoshida, Naohiro; Iino, Yukiko

    2014-08-01

    This study investigated the difference in clinical characteristics of fallopian canal dehiscence associated with pars flaccida and pars tensa cholesteatomas for the purpose of increasing the preoperative detectability of dehiscence. A total of 189 ears of patients 7-80 years of age (mean 42 years) with pars flaccida cholesteatoma and 63 ears of patients 9-84 years of age (mean 50 years) with pars tensa cholesteatoma were studied. All patients had undergone prior surgical management at our institution from January 2006 to April 2012. The incidence of fallopian canal dehiscence and its location were compared between pars flaccida and pars tensa cholesteatomas. Intraoperative findings of coexistent pathologies, including destruction of the stapes superstructure, labyrinthine fistula, and dural exposure, were compared between the dehiscence and no-dehiscence groups for the two types of cholesteatomas. The incidence of dehiscence was significantly higher in patients with pars tensa cholesteatoma (55.6 %) than in patients with pars flaccida cholesteatoma (26.5 %). Dehiscence located posterior to the cochleariform process occurred slightly more frequently in patients with pars tensa cholesteatoma than in those with pars flaccida cholesteatoma. In patients with pars flaccida cholesteatoma, labyrinthine fistulas and dural exposure were significantly more frequent in the dehiscence group than in the no-dehiscence group. Fallopian canal dehiscence is more frequent in patients with pars tensa cholesteatoma than in those with pars flaccida cholesteatoma. Especially in patients with pars flaccida cholesteatoma, paying special attention to these coexisting pathologies is important to increase preoperative detectability of dehiscence.

  11. Incidencia del control interno en la gestión del área de compras de la empresa ETTUSA de la provincia de Cañete, 2015

    OpenAIRE

    Lozano Guerra, Espiritu Ciencia

    2016-01-01

    La presente investigación tuvo como objetivo general, determinar y describir la incidencia del control interno en la gestión del área de compras de la empresa ETTUSA de la Provincia de Cañete, 2015. La investigación fue de diseño no experimental, bibliográfico y de caso, para el recojo de información se utilizó fichas bibliográficas y un cuestionario al personal de la empresa y al jefe del área de compras en aplicación a los cinco componentes del control interno según la resolución 458-2008-G...

  12. Routine Isotopic Analysis of {sup 235}U by Emission Spectrometry. 1. Interferometry using electrode-less discharge lamps 2. determination of the {sup 235}U/{sup 238}U ratio using a spectrograph and electrode-less lamps; Contribution a l'analyse isotopique de routine de l'uranium 235 par spectrometrie d'emission. 1. interferometrie avec des lampes a decharge sans electrode. 2. determination du rapport {sup 235}U/{sup 238}U a l'aide d'un spectrographe et avec des lampes sans electrodes

    Energy Technology Data Exchange (ETDEWEB)

    Capitini, R.; Ceccaldi, M.; Leicknam, J.P.; Rabec, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1970-07-01

    reproductibilite des mesures est voisine de 2 pour cent, la precision relative etant de {+-} 2 a 3 pour cent; pour des echantillons enrichis en uranium 235 (5 a 93 pour cent), la precision relative atteint {+-} 0.5 pour cent. II. Malgre le tres grand nombre de travaux effectues pour ameliorer la precision des analyses isotopiques de l'uranium par voie optique, il n'a jusqu'a present pas ete possible de mettre au point une methode permettant de concurrencer la spectrometrie de masse. Cependant, lorsqu'on n'a pas besoin d'une tres grande precision, la spectrometrie d'emission, qui ne presente pas d'effet de memoire, peut constituer une methode d'analyse complementaire, si elle est suffisamment rapide et economique; pour qu'il en soit ainsi, il nous semble qu'une telle methode doit pouvoir etre appliquee dans les laboratoires equipes d'appareils d'analyses spectrochimiques courants. (auteur) [abstract truncated

  13. Etude Par Spectroscopie Infrarouge des Oxydes Moleculaires Superoxyde de Potassium, Peroxyde de Potassium et Trioxyde de Silicium Isoles EN Matrice D'argon

    Science.gov (United States)

    Tremblay, Benoit

    1995-01-01

    A l'aide de la spectroscopie d'absorption infrarouge et de la technique d'isolation en matrice d'argon, nous avons repris l'etude des differents oxydes moleculaires qui se forment lorsque l'oxygene moleculaire se trouve dans des agregats avec du potassium, du silicium et de l'oxyde de silicium SiO. Le choix des oxydes moleculaires KO_2 et K_2O_2 a ete motive par le fait qu'ils ont souvent ete mis en evidence dans tres travaux en physique des surfaces lors de letude du systeme O_2/K/Si. Ces oxydes avaient deja ete identifies par spectroscopie infrarouge en matrice d'argon au debut des annees soixante-dix. Pour KO_2, l'observation des modes nu_2 et nu_3 pour de nombreuses especes isotopiques nous a permis de deduire la longueur de la liaison K-O et de l'angle O-K-O. En effet, la construction d'un champ de force harmonique nous a permis de determiner sa structure et des constantes de force qui reprodusient tres bien les frequences experimentales observees. L'etude de l'oxyde K_2O _2 s'est averee interessante car avant notre travail, seule une vibration avait ete mise en evidence. Nous avons reussi a observer deux nouvelles vibrations fondamentales: une bande infrarouge faible a 185 cm^{-1}, avec les isotopes ^{16}O _2, ^{18}O _2 et ^{16} O^{18}O de l'oxygene, et une autre, activee en infrarouge avec l'isotope ^{16}O^{18 }O a 405 cm^{-1}. Les donnees experimentales etant insuffisantes pour deduire la structure de la molecule, des calculs theoriques avec la methode de la fonctionnelle de la densite ont donne le structure et les vibrations non observees du K _2O_2. Ces donnees supplementaires sont venues completer les resultats experimentaux et nous ont permis de construire un champ de force harmonique avec bien les frequences observees. Les calculs theoriques ont monte que K_2O _2 doit etre de structure C_ {rm 2v}, bien que la structure D _{rm 2h} ne puisse pas etre rejetee, puisque qu'il y a un faible ecart entre les resultats des deux structures. Ensuite, nous avons

  14. Conception et calibration d'un sonoreacteur pour l'oxydation de la cellulose par le systeme TEMPO/NaOCl/NaBr

    Science.gov (United States)

    Paquin, Michel

    grande consommation d'energie et de reactif qui rend le procede difficilement accessible au milieu industriel. L'utilisation des ultrasons lors de la reaction d'oxydation permet de reduire de 50% le temps de reaction et d'autant la consommation de produits chimiques. Actuellement le processus d'oxydation s'effectue en mode discontinu pour une quantite de 20 grammes de pate dans un reacteur en verre dans un bain a ultrason. L'objectif principal de ce travail est d'elaborer un sonoreacteur en mode semi-continu afin d'etre en mesure de transferer une reaction d'oxydation du mode discontinu en mode semi-continu. Le transfert de reaction sera effectue en realisant la calibration de l'activite acoustique des deux differents reacteurs, discontinu et semi-continu, par la methode de Weissler. La methode de Weissler quantifie le taux de production radicalaire en mesurant la formation d'iode moleculaire d'une solution aqueuse d'iodure de potassium sous ultrason. Suite a sa calibration, le sonoreacteur pilote (mode semi-continu) a demontre une augmentation de la production radicalaire de 683 % a 170 kHz en comparaison avec l'utilisation d'un bain a ultrason a la meme frequence. Lors de la reaction d'oxydation, la puissance optimale utilisee dans le bain a ultrason a 170 kHz est de 1000 W. La puissance utilisee selon les resultats de calibration obtenue dans le sonoreacteur pilote est de 125 W soit une diminution de l'energie appliquee de 87,5 %. Lors de la reaction d'oxydation, le taux de production des groupements carboxylates est de 2,6 mmol COOH kg/min dans le bain a ultrason et de 6,87 mmol COOH kg/min dans le sonoreacteur pilote soit une augmentation de 164% du taux de formation. Selon les resultats obtenus, l'utilisation d'un sonoreacteur en mode continu peut etre envisageable pour la reaction d'oxydation de la cellulose par le systeme TEMPO-NaOCl-NaBr en industrie au niveau industriel.

  15. Isotopic exchange between molecular hydrogen and liquid ammonia catalysed by alkali amides; Echange isotopique entre l'hydrogene moleculaire et l'ammoniac liquide catalyse par les amidures alcalins

    Energy Technology Data Exchange (ETDEWEB)

    Delmas, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-06-15

    The catalytic action of alkali amides on the isotopic exchange between hydrogen and liquid ammonia has been reinvestigated. It was clear before this work that the reaction is homogeneous and first order with respect to the concentration of dissolved hydrogen, but the nature of the catalytic species was still subject to discussion. On one hand new precise kinetic measurements have been made with sodium, potassium, rubidium and cesium amide. On the other hand, the dissociation of these salts has been calculated with the help of the FUOSS-ONSAGER equation. If the rate of exchange is plotted as a function of the concentration of the free amide ion, a linear relationship is obtained. In our experimental conditions, primary salt effects are negligible and the concentration has to be used in the rate equations. This shows that only the free amide ion is acting as a catalytic species. Experiments on common ion effects and secondary salt effects support this conclusion. The results are in agreement with an associative mechanism. (author) [French] Une nouvelle etude de l'echange isotopique entre l'hydrogene et l'ammoniac liquide catalyse par les amidures alcalins a ete effectuee. II etait bien etabli avant le present travail que la reaction etait homogene et que sa vitesse etait du premier ordre par rapport a la concentration d'hydrogene dissous, mais la nature de l'espece catalytique etait encore controversee. De nouvelles mesures cinetiques precises ont ete faites avec les amidures de sodium, de potassium, de rubidium et de cesium. D'autre part, la dissociation de ces sels a ete calculee a l'aide de l'equation de FUOSS-ONSAGER. On constate que la vitesse d'echange est proportionnelle a la concentration de l'ion amidure libre. Dans nos conditions experimentales, les effets de sel primaires sont negligeables, l'equation de vitesse doit s'exprimer simplement en fonction des concentrations. Ceci indique que l

  16. The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae.

    Science.gov (United States)

    Attaiech, Laetitia; Minnen, Anita; Kjos, Morten; Gruber, Stephan; Veening, Jan-Willem

    2015-06-30

    ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic human pathogen Streptococcus pneumoniae contains four parS sequences located close to the origin of replication which are bound by ParB. Using chromatin immunoprecipitation (ChIP), we found here that ParB spreads out from one of these parS sites, parS(-1.6°), for more than 5 kb and occupies the nearby comCDE operon, which drives competence development. Competence allows S. pneumoniae to take up DNA from its environment, thereby mediating horizontal gene transfer, and is also employed as a general stress response. Mutating parS(-1.6°) or deleting parB resulted in transcriptional up-regulation of comCDE and ssbB (a gene belonging to the competence regulon), demonstrating that ParB acts as a repressor of competence. However, genome-wide transcription analysis showed that ParB is not a global transcriptional regulator. Different factors, such as the composition of the growth medium and antibiotic-induced stress, can trigger the sensitive switch driving competence. This work shows that the ParB-parS chromosome segregation machinery also influences this developmental process. Streptococcus pneumoniae (pneumococcus) is an important human pathogen responsible for more than a million deaths each year. Like all other organisms, S. pneumoniae must be able to segregate its chromosomes properly. Not only is understanding the molecular mechanisms underlying chromosome segregation in S. pneumoniae therefore of fundamental importance, but also, this knowledge might offer new leads for ways to target this pathogen. Here, we identified a link between the pneumococcal chromosome segregation system and the competence-developmental system. Competence allows S. pneumoniae to take up and integrate exogenous DNA in its chromosome. This process plays a crucial role in successful adaptation to--and escape from

  17. Avaliação de desempenho de wetlands construídos para o tratamento de efluente de reator UASB: estudo de caso da ete vog ville

    Directory of Open Access Journals (Sweden)

    Luciano de Souza Ferreira

    2015-12-01

    Full Text Available Um sistema de tratamento de esgoto sanitário, em escala real, composto por reator UASB seguido de wetlands construídos de fluxo horizontal subsuperficial foi avaliado quanto ao comportamento, eficiências de remoção de poluentes e seus aspectos operacionais. O processo foi estudado em duas etapas caracterizadas pela presença e ausência da recirculação do efluente final em duas unidades de wetlands construídos plantadas com diferentes espécies de macrófitas. As faixas de valores das concentrações efluentes dos parâmetros analisados foram: matéria orgânica medida como DQO, 26 a 96 mgO2/L; Sólidos em Suspensão Totais, 2 a 29 mg/L; Sólidos em Suspensão Voláteis, 0 a 27 mg/L; Nitrogênio Total Kjedhal, 17,9 a 72,8 mg/L; nitrogênio amoniacal, 15,4 e 58,8 mg/L; P-PO43-: 3,9 a 9,4 mg/L; fósforo total, 5,6 a 8,5 mg/L; Coliformes Termotolerantes: 104 a 105 NMP/100mL e Coliformes Totais: 105 a 106 NMP/100mL. A aplicação do teste não paramétrico de Wilcoxon-Mann-Whitney em nível de significância igual a 5% mostrou que não houve diferença significativa entre o desempenho de remoção de poluentes durante as duas etapas da pesquisa, nem entre as unidades plantadas com macrófitas distintas. O presente estudo mostrou que wetlands construídos de fluxo horizontal subsuperficial tratando o efluente de reator UASB são capazes de atender a maioria dos padrões de lançamento preconizados na legislação ambiental vigente. O estudo, também, permitiu concluir que há necessidade de uma operação intensa e contínua para se garantir condições adequadas de funcionamento de tais sistemas. 

  18. ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes.

    Directory of Open Access Journals (Sweden)

    Virginia S Lioy

    Full Text Available In Firmicutes, small homodimeric ParA-like (δ2 and ParB-like (ω2 proteins, in concert with cis-acting plasmid-borne parS and the host chromosome, secure stable plasmid inheritance in a growing bacterial population. This study shows that (ω:YFP2 binding to parS facilitates plasmid clustering in the cytosol. (δ:GFP2 requires ATP binding but not hydrolysis to localize onto the cell's nucleoid as a fluorescent cloud. The interaction of (δ:CFP2 or δ2 bound to the nucleoid with (ω:YFP2 foci facilitates plasmid capture, from a very broad distribution, towards the nucleoid and plasmid pairing. parS-bound ω2 promotes redistribution of (δ:GFP2, leading to the dynamic release of (δ:GFP2 from the nucleoid, in a process favored by ATP hydrolysis and protein-protein interaction. (δD60A:GFP2, which binds but cannot hydrolyze ATP, also forms unstable complexes on the nucleoid. In the presence of ω2, (δD60A:GFP2 accumulates foci or patched structures on the nucleoid. We propose that (δ:GFP2 binding to different nucleoid regions and to ω2-parS might generate (δ:GFP2 gradients that could direct plasmid movement. The iterative pairing and unpairing cycles may tether plasmids equidistantly on the nucleoid to ensure faithful plasmid segregation by a mechanism compatible with the diffusion-ratchet mechanism as proposed from in vitro reconstituted systems.

  19. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  20. Developpement d'outils quantitatifs pour le suivi par imagerie TEP/TDM de la reponse a la chimiotherapie et de sa toxicite

    Science.gov (United States)

    Croteau, Etienne

    L'objectif de ce projet de doctorat est de developper des outils quantitatifs pour le suivi des traitements de chimiotherapie pour le cancer du sein et de leurs effets cardiotoxiques a l'aide de l'imagerie TEP dynamique. L'analyse cinetique en TEP dynamique permet l'evaluation de parametres biologiques in vivo. Cette analyse peut etre utilise pour caracteriser la reponse tumorale a la chimiotherapie et les effets secondaires nefastes qui peuvent en resulter. Le premier article de cette these decrit la mise au point des techniques d'analyse cinetique qui utilisent la fonction d'entree d'un radiotraceur derive de l'image dynamique. Des corrections de contamination radioactive externe (epanchement) et de l'effet de volume partiel ont ete necessaires pour standardiser l'analyse cinetique et la rendre quantitative. Le deuxieme article porte sur l'evaluation d'un nouveau radiotraceur myocardique. Le 11C-acetoacetate, un nouveau radiotraceur base sur un corps cetonique, a ete compare au 11C-acetate, couramment utilise en imagerie cardiaque TEP. L'utilisation de 3H-acetate et 14C-acetoacetate ont permis d'elucider la cinetique de ces traceurs depuis la fonction d'entree et la captation par les mitochondries cardiaques qui reflete la consommation en oxygene, jusqu'a la liberation de leurs principaux metabolites reciproques (3H20 et 14CO2). Le troisieme et dernier article de cette these presente l'integration d'un modele qui evalue la reserve cardiaque de perfusion et de consommation en oxygene. Un modele de cardiomyopathie a ete etabli a l'aide d'un agent chimiotherapeutique contre le cancer du sein, la doxorubicine, reconnu comme etant cardiotoxique. Un protocole de repos/effort a permis d'evaluer la capacite d'augmentation de perfusion et de consommation en oxygene par le coeur. La demonstration d'une reserve cardiaque reduite caracterise la cardiotoxicite. La derniere contribution de cette these porte sur la mise au point de methodes peu invasives pour mesurer la

  1. Experimental contamination of margaritana margaritifera (L) (a Fresh water bivalve) by caesium 137; Contamination experimentale de margaritana margaritifera (L) (bivalve d'eau douce) par le cesium 137

    Energy Technology Data Exchange (ETDEWEB)

    Foulquier, L.; Bovard, P.; Grauby, A. [Commissariat a l' Energie Atomique, Cadarache (France). Centre d' Etudes Nucleaires

    1966-07-01

    The hydro biological research carried out in the Radio-Ecology Section has led the authors to study some Margaritana sampling stations situated down-stream from the Monts d'Arree nuclear power station. They describe the preservation and contamination methods used for fixing the {sup 137}Cs concentration factors in the case of Margaritana Margaritifera (L). The results of experiments carried out over a period of one hundred days show that the specific activity of the various organs is stabilized after thirty to thirty-five days. The authors have noticed a relatively low adsorption on the shell through the intermediary of micro-organisms, and a strong and rapid absorption in the soft parts. The concentration factors have values, at equilibrium, of around: 9 for the shell, 300 for all the organs, and 38 for the whole animal. A comparison of these results with work published by other authors makes it possible to draw general conclusions concerning the mechanism of {sup 137}Cs fixation by lamellibranch, as well as their capacity of fixation. (author) [French] Les etudes hydrobiologiques effectuees au sein de la Section de Radio-Ecologie ont amene les auteurs a etudier des stations de prelevement de Margaritana en aval de la Centrale Nucleaire des Monts d'Arree. Ils decrivent les methodes de conservation et de contamination utilisees pour l'etablissement des facteurs de concentration du {sup 137}Cs par Margaritana margaritifera (L). Les resultats des experimentations menees pendant cent jours montrent que les activites specifiques de la coquille et des differents organes se stabilisent au bout de trente a trente-cinq jours. Les auteurs constatent une adsorption relativement faible sur la coquille par l'intermediaire des micro-organismes et une absorption forte et rapide dans les parties molles. Les facteurs de concentration se situent, a l'equilibre, autour de: 9 pour la coquille, 300 pour l'ensemble des organes et 38 si l'on considere

  2. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  3. Contribution to the study of the structure and reactivity of ketones using deuterium substitution of the {alpha} - ketone hydrogens; Contribution a l'etude de la structure et de la reactivite des cetones, par utilisation de la substitution deuteriee des hydrogenes {alpha}-cetoniques

    Energy Technology Data Exchange (ETDEWEB)

    Frejaville, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1966-02-01

    This work is an attempt to obtain more knowledge about the structure and the reactivity of ketones; it is also a contribution to conformational analysis based on infrared signals associated with the C-D vibration in mono-deuterated compounds. In the first chapter the various dosage and synthetic methods used in this work are described. In the second chapter the infrared spectra in the 2100-2200 cm{sup -1} region for mono-deuterated ketones are interpreted on the basis of a simple model. This model is then studied in detail, and also critically and precisely, in the case of the mono deuterated acetone molecule. In the third chapter is studied the mechanism of the Favorskii reaction and the reactivity of all the {alpha}-ketonic hydrogens of 2 chloro-cyclohexanone are classified. In a technical appendix is described a counter-current exchange method for obtaining a great variety of solvents and deuterated pure raw materials under advantageous conditions. (author) [French] Ce travail est un effort vers une meilleure connaissance de la structure et de la reactivite des cetones; c'est egalement une contribution a l'analyse conformationnelle d'apres l'etude des signaux infrarouges associes a la vibration C-D dans les composes monodeuteries. Dans le premier chapitre sont decrites les differentes methodes de dosage et de synthese qui ont ete utilisees dans ce travail. Dans le deuxieme chapitre, les spectres infrarouges dans la region 2100-2200 cm{sup -1} de cetones monodeuteriees sont interpretes sur la base d'un modele simple. Ce modele est ensuite etudie de facon detaillee, critique et precise sur la molecule d'acetone monodeuteriee. Dans le troisieme chapitre on etudie le mecanisme de la reaction de FAWORSKII et l'on classe la reactivite de tous les hydrogenes {alpha}-cetoniques de la chloro-2-cyclohexanone. Dons l'appendice technique on decrit la mise en oeuvre d'un appareil d'echange a contre-courant qui permet d

  4. Caracterisation des etats de surface par teledetection infrarouge thermique multispectrale: Contribution a l'etude des conditions de viabilite hivernale

    Science.gov (United States)

    Chagnon, Frederic

    La mesure de temperature d'une surface et de son emissivite thermique constitue encore de nos jours, un defi de taille. D'un point de vue microclimatique, la temperature significative d'une surface est celle qui reflete l'etat des echanges energetiques qui y ont lieu. La radiometrie infrarouge thermique permet de lire la temperature de l'interface air-sol pour une couche infiniment petite de la surface (de l'ordre de quelques microns). Dans le cadre d'un systeme d'aide aux decisions en viabilite hivernale, nous avons defini un prototype de station de mesures mobiles. Cette station permet de determiner, avec precision, la temperature radiative de la surface de la chaussee ainsi que de determiner, avec un taux de succes de plus de 65 %, l'etat de cette meme surface. Par la conception de ce prototype, nous avons aborde le principe physique de la mesure de temperature de surface par radiometrie multispectrale infrarouge thermique. Ce travail aura permis d'evaluer une approche standard de mesure a bande spectrale unique (de 8 a 14 mum). Dans la correction de la temperature radiative de surface, nous avons considere trois methodes distinctes. La premiere methode utilisee est celle de l'algorithme TES (Gillespie et al., 1998). Cet algorithme etablit le spectre d'emissivite, puis calcule une temperature de surface corrigee, en tenant compte de la reflexion du rayonnement thermique incident a la surface. La seconde methode consideree est l'indice TISI (Li et al., 1999) qui consiste en un indice d'emissivite relatif independant de la temperature de la surface et qui tient compte du rayonnement incident a la surface. La troisieme methode est un indice de temperature relative (ITR) qui correspond au contraste normalise des temperatures radiatives de surface. L'identification du type de surface a montre un taux de succes de 54,8 % pour les resultats de l'indice ITR, de 51,9 % pour les resultats de l'indice TISI et de 67,3 % pour les resultats de l'algorithme TES. Quant a la

  5. Structural analysis of the ParR/parC plasmid partition complex

    DEFF Research Database (Denmark)

    Møller-Jensen, Jakob; Ringgaard, Simon; Mercogliano, Christopher P

    2007-01-01

    . coli plasmid pB171. ParR forms a tight dimer resembling a large family of dimeric ribbon-helix-helix (RHH)2 site-specific DNA-binding proteins. Crystallographic and electron microscopic data further indicate that ParR dimers assemble into a helix structure with DNA-binding sites facing outward. Genetic...

  6. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  7. LES LESIONS DES ORGANES GENITAUX EXTERNES PAR ARME A

    African Journals Online (AJOL)

    Les lésions par arme à feu définies comme toute blessure produite sur le corps humain par rapprochement ou le choc d'une arme à feu, sont généralement rares qu'il s'agisse de plaies par armes de guerre ou de plaies par projectiles dans un contexte civil“. Parmi les facteurs de gravité des plaies par balles figu-.

  8. Traitement des eaux par électrofloculation

    OpenAIRE

    Cansado, Isabel

    1997-01-01

    Traitement des eaux par electrofloculation Les écosystèmes aquatiques sont très affectés par les eaux de rejet qui sont déversées dans les cours d’eau. La charge de ces eaux existe sous diverses formes: solutés, colloïdes ou particules. Il est important de traiter l’eau usée à de faibles coûts au lieu de la rejeter directement dans le milieu récepeteur. Dans le but d’améliorer les procédés physico-chimiques de déstabilisation des émulsions, nous étudions les traitements par électrocoagulat...

  9. Les effets du travail en equipe dans l'apprentissage par projets sur la motivation des etudiantes et des etudiants en formation des ingenieurs

    Science.gov (United States)

    Fernandez, Nicolas

    Les representants des secteurs industriels et les, milieux professionnels en Amerique du Nord reprochaient aux universites de former des ingenieurs avec peu d'experience pratique en resolution de problemes et en conception. Quelques programmes de genie ont alors mis en place le travail en equipe dans l'apprentissage par projets. Beaucoup d'ecrits font valoir les benefices de l'apprentissage par projets sur la motivation des etudiants. Or, ces benefices commencent a peine a faire l'objet de recherches visant a produire des donnees probantes a ce sujet. Les travaux sur la motivation en contexte d'apprentissage et les modeles theoriques developpes sont issus d'environnements d'apprentissage marques par l'enseignement magistral. Le modele de la valeur attendue de la tache (Eccles et Wigfield, 1995; Neuville, 2004) et le modele du systeme-groupe (St-Arnaud, 2008) ont ete retenus pour mesurer les effets du travail en equipe dans l'apprentissage par projets sur la motivation. La recherche visait aussi a approfondir et a nuancer la comprehension de la motivation des etudiants universitaires apprenant en contexte innovant. Les sujets constituent des etudiants (n=100) travaillant sur des projets d'integration au cours des trois sessions initiales du programme de genie mecanique d'une universite canadienne. L'analyse de regression multiple revele que les construits de la motivation expliquent un tiers de la variance de l'engagement academique dans la realisation du projet d'integration. Les perceptions de l' "expectancy", de la valeur intrinseque et utilitaire sont les determinants principaux de l'engagement des etudiants. L'analyse de variance multivariee a mesures repetees indique que la motivation des etudiants pour le travail sur les projets d'integration a augmente au cours des trois sessions initiales du parcours de formation. Finalement, malgre l'absence d'interaction significative entre les variables de motivation et de l'equipe, les reponses des sujets indiquent une

  10. Étude de l'activité antifalcemiante et de la thermo- et photo ...

    African Journals Online (AJOL)

    Lfactivite antifalcemiante des feuilles de Centella asiatica (L.) Urb. et Thomandersia hensii De Wild. & T. Durand et des ecorces de la tige de Maesopsis eminii Engl. ; trois plantes utilisees en medicine traditionnelle contre la drepanocytose dans la ville de Kisangani (RD Congo), a ete testee en utilisant le test dfEmmel.

  11. A 66-kDa protein of bovine hypophyseal Pars tuberalis induces luteinizing hormone release from rat Pars distalis.

    Science.gov (United States)

    Lafarque, Martha; Oliveros, Liliana

    2008-12-01

    In this study, evidence for a factor secreted by bovine hypophyseal pars tuberalis that stimulates luteinizing hormone (LH) release from rat pars distalis cells is shown. The secretion products of bovine pars tuberalis cells into the culture medium were assayed on dispersed rat pars distalis cells in 30 min incubations and superfusion experiments. The culture medium from pars tuberalis total cell populations, added at a dose of 6 microg per tube, induced the greater LH release from pars distalis cells, without effect on follicle stimulating hormone (FSH) release. After pars tuberalis cells separation on a discontinuos Percoll gradient, only the culture medium of cells from 50 and 60% strength Percoll were able to release LH from rat pars distalis cells. Therefore, cell fractions from 50 and 60% strenght Percoll were cultured together. To elicit maximal LH release (6 times the basal output), with the addition of 2 microg of pars tuberalis protein was required, suggesting that these cells produce the factor or factors which affect pars distalis gonadotrope cells. After applying the pars tuberalis culture medium on 12% SDS-PAGE, the band with biological activity was that of 66-kDal. Fifty ng protein of its eluate released almost 9 times the basal output of LH from pars distalis cells. Results suggest a modulating effect of a protein from the bovine pars tuberalis on rat cultured gonadotrope cells from the pars distalis.

  12. Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

    Science.gov (United States)

    Bourdi, Taoufik

    Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents

  13. Spectroscopie du Furanne et du Thiophene Par Diffusion Inelastique D'electrons

    Science.gov (United States)

    Lotfi, Said

    Nous avons etudie les molecules de furanne ( rm C_4H_4O) et de thiophene (rm C_4H_4O) au moyen de la spectroscopie de diffusion inelastique d'electrons. Pour (rm C_4H_4O), les spectres realises dans differentes conditions d'energie d'impact et d'angle de diffusion contiennent des singularites ou des families de pics correspondant a: (1) des vibrations de l'etat fondamental dans le domaine 0-0.5 eV, (2) des etats triplets ^3 B_1 et ^3 A_1 qui dominent la region 3-5.5 eV, (3) des etats de valences, entre 5 et 10 eV, dont certains son accompagnes de progressions vibrationnelles, soit ~ A _1B_2, ~ B ^1A_1 et ~ C ^1A_1, (4) toujours entre 5 et 10 eV, deux series de Ryhdberg (rm 1a_2to nda_2 et rm 1a_2to npb_2) qui convergent vers la premiere limite d'ionisation de la molecule, avec une progression vibrationnelle associee au mdoe nu_4 pour la seconde, et une troisieme serie (rm 2b_1to nsa_1 ) convergent vers la seconde limite d'ionisation accompagnee de la progression de mode nu _1. Pour rm C_4H_4S, nos spectres presentent les memes etats de vibration et les memes etats triplets que pour rm C_4H _4O. Nous avons releve egalement, dans la region de 5 a 10 eV, des etats de valence ~ A ^1A_1 (ou ~ A ^1B_2), ~ B ^1A_1 (ou ~ B ^1B _2) et ~ C ^1A_1 (ou ~ C ^1B_2). Pour la premiere fois, par la spectroscopie de diffusion inelastique d'electrons, de nombreux pics ont ete identifies et attribues, dans le cadre de ce travail. Il s'agit, notamment, des etats de vibration de l'etat electronique fondamental de ces molecules et egalement de certains etats de Rydberg dans le cas du furanne.

  14. Par-4: A New Activator of Myosin Phosphatase

    Science.gov (United States)

    Vetterkind, Susanne; Lee, Eunhee; Sundberg, Eric; Poythress, Ransom H.; Tao, Terence C.; Preuss, Ute

    2010-01-01

    Myosin phosphatase (MP) is a key regulator of myosin light chain (LC20) phosphorylation, a process essential for motility, apoptosis, and smooth muscle contractility. Although MP inhibition is well studied, little is known about MP activation. We have recently demonstrated that prostate apoptosis response (Par)-4 modulates vascular smooth muscle contractility. Here, we test the hypothesis that Par-4 regulates MP activity directly. We show, by proximity ligation assays, surface plasmon resonance and coimmunoprecipitation, that Par-4 interacts with the targeting subunit of MP, MYPT1. Binding is mediated by the leucine zippers of MYPT1 and Par-4 and reduced by Par-4 phosphorylation. Overexpression of Par-4 leads to increased phosphatase activity of immunoprecipitated MP, whereas small interfering RNA knockdown of endogenous Par-4 significantly decreases MP activity and increases MYPT1 phosphorylation. LC20 phosphorylation assays demonstrate that overexpression of Par-4 reduces LC20 phosphorylation. In contrast, a phosphorylation site mutant, but not wild-type Par-4, interferes with zipper-interacting protein kinase (ZIPK)-mediated MP inhibition. We conclude from our results Par-4 operates through a “padlock” model in which binding of Par-4 to MYPT1 activates MP by blocking access to the inhibitory phosphorylation sites, and inhibitory phosphorylation of MYPT1 by ZIPK requires “unlocking” of Par-4 by phosphorylation and displacement of Par-4 from the MP complex. PMID:20130087

  15. CFD analysis of PAR performance as function of inlet design

    Energy Technology Data Exchange (ETDEWEB)

    Park, Kweonha, E-mail: khpark@kmou.ac.kr [Division of Mechanical and Energy systems Engineering, Korea Maritime University, Dongsam-dong, Yeongdo-gu, Busan 606-791 (Korea, Republic of); Khor, Chong Lee, E-mail: itachi_829@hotmail.com [Department of Mechanical Engineering, Korea Maritime University (Korea, Republic of)

    2016-01-15

    Highlights: • The new concept of PAR (passive autocatalytic recombiner) was proposed and analyzed. • Guidance wall was added at the bottom of PAR to enhance the flow rate through the catalyst. • The new concept of PAR was proved to have a better hydrogen removal performance. - Abstract: Passive autocatalytic recombiner (PAR) is very useful hydrogen mitigation measurement. It is widely implemented in the current and advanced light water reactors (ALWRs). The design of the PARs should be optimized for the specific use under severe accident scenarios. Several techniques and innovations have been fused into the PAR, as an effort to increase its efficiency of hydrogen mitigation. This study proposes different concepts of PAR, which applied some changes to the honeycomb catalyst PAR made by the Korea Nuclear Technology (KNT) Inc. Two slices of plate are added to the bottom of PAR model, which intended to act as a reflection wall and promote the gas flow into PAR. Hydrogen volume fraction was given 4 vol. % which tested by KNT to investigate the performance of PAR in different direction gas flow conditions to see maximum hydrogen recombination rate. The new concept of PAR was proved to have a better hydrogen removal performance compared to the original honeycomb catalyst PAR.

  16. PAR-TERRA directs homologous sex chromosome pairing.

    Science.gov (United States)

    Chu, Hsueh-Ping; Froberg, John E; Kesner, Barry; Oh, Hyun Jung; Ji, Fei; Sadreyev, Ruslan; Pinter, Stefan F; Lee, Jeannie T

    2017-08-01

    In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells. The subtelomeric, pseudoautosomal regions (PARs) of the two sex chromosomes (X and Y) also undergo pairing in both female and male cells. PARs transcribe a class of telomeric RNA, dubbed PAR-TERRA, which accounts for a vast majority of all TERRA transcripts. PAR-TERRA binds throughout the genome, including to the PAR and Xic. During X-chromosome pairing, PAR-TERRA anchors the Xic to the PAR, creating a 'tetrad' of pairwise homologous interactions (Xic-Xic, PAR-PAR, and Xic-PAR). Xic pairing occurs within the tetrad. Depleting PAR-TERRA abrogates pairing and blocks initiation of XCI, whereas autosomal PAR-TERRA induces ectopic pairing. We propose a 'constrained diffusion model' in which PAR-TERRA creates an interaction hub to guide Xic homology searching during XCI.

  17. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly...

  18. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign...

  19. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  20. Prediction des vibrations eoliennes d'un systeme conducteur-amortisseur avec une methode temporelle non lineaire

    Science.gov (United States)

    Langlois, Sebastien

    Les vibrations eoliennes sont la cause principale de bris de conducteurs en fatigue des lignes aeriennes de transport d'energie electrique. Ces vibrations sont dues a des detachements tourbillonnaires produits dans le sillage du conducteur. Une methode commune de reduction des vibrations est l'ajout d'amortisseurs de vibrations pres des pinces de suspension. Contrairement aux essais en ligne experimentale, la modelisation numerique permet d'evaluer rapidement et a faible cout la performance d'un amortisseur de vibration sur une portee de ligne aerienne. La technologie la plus frequemment utilisee fait appel au principe de balance d'energie (PBE) en evaluant le niveau de vibrations pour lequel la puissance injectee par le vent est egale a la puissance dissipee par le conducteur et l'amortisseur. Les methodes actuelles pour la prediction des vibrations reposent sur des hypotheses simplificatrices quant a la modelisation de l'interaction conducteur-amortisseur. Une approche prometteuse pour la prediction des vibrations est l'utilisation d'un modele numerique temporel non lineaire qui permet de mieux representer la masse, la geometrie, la rigidite et l'amortissement du systeme. L'objectif principal de ce projet de recherche est de developper un modele numerique avec integration temporelle directe d'un conducteur et d'un amortisseur en vibration permettant de reproduire le comportement dynamique du systeme pour la gamme de frequence et d'amplitude typique des vibrations eoliennes des conducteurs. Un modele par elements finis d'un conducteur seul en vibration resolu par integration temporelle directe a d'abord ete developpe en considerant une rigidite de flexion variable. Comme une rigidite de flexion constante et egale a 50% de la rigidite de flexion maximale theorique ( EImax) est jugee adequate pour la modelisation du conducteur, c'est cette valeur qui a ete utilisee pour la suite du projet. Ensuite, des modeles non-lineaires pour deux types d'amortisseur de

  1. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition

    Energy Technology Data Exchange (ETDEWEB)

    Chaudhuri, Barnali [University of Buffalo, The State University of New York; Gupta, Sayan [Case Western Reserve University; Urban, Volker S [ORNL; Chance, Mark [Case Western Reserve University; D' Mello, Rhijuta [Case Western Reserve University; Smith, Lauren [University of Buffalo, The State University of New York; Lyons, Kelly [University of Buffalo, The State University of New York; Gee, Jessica [University of Buffalo, The State University of New York

    2010-01-01

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  2. A Combined Global and Local Approach to Elucidate Spatial Organization of the Mycobacterial ParB-parS Partition Assembly

    Energy Technology Data Exchange (ETDEWEB)

    B Chaudhuri; S Gupta; V Urban; M Chance; R DMello; L Smith; K Lyons; J Gee

    2011-12-31

    Combining diverse sets of data at global (size, shape) and local (residue) scales is an emerging trend for elucidating the organization and function of the cellular assemblies. We used such a strategy, combining data from X-ray and neutron scattering with H/D-contrast variation and X-ray footprinting with mass spectrometry, to elucidate the spatial organization of the ParB-parS assembly from Mycobacterium tuberculosis. The ParB-parS participates in plasmid and chromosome segregation and condensation in predivisional bacterial cells. ParB polymerizes around the parS centromere(s) to form a higher-order assembly that serves to recruit cyto-skeletal ParA ATPases and SMC proteins for chromosome segregation. A hybrid model of the ParB-parS was built by combining and correlating computational models with experiment-derived information about size, shape, position of the symmetry axis within the shape, internal topology, DNA-protein interface, exposed surface patches, and prior knowledge. This first view of the ParB-parS leads us to propose how ParB spread on the chromosome to form a larger assembly.

  3. Host response biomarker in sepsis: suPAR detection.

    Science.gov (United States)

    Giamarellos-Bourboulis, Evangelos J; Georgitsi, Marianna

    2015-01-01

    Recent studies of our group have shown that suPAR may complement APACHE II score for risk assessment in sepsis. suPAR may be measured in serum of patients by an enzyme immunosorbent assay developed by Virogates (suPARnostic™). Production of suPAR from circulating neutrophils and monocytes may be assessed after isolation of neutrophils and monocytes and ex vivo culture. This is followed by measurement of suPAR in culture supernatants.

  4. Decontamination by fractional distillation of a radioactive mixture of perchlorethylene, bitumen, and sludges from chemical co-precipitations; Decontamination par distillation fractionnee d'un melange radioactif constitue par du perchlorethylene, du bitume et des boues de coprecipitation chimique

    Energy Technology Data Exchange (ETDEWEB)

    Lefillatre, G.; Hullo, R. [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1969-07-01

    It is not possible to incinerate the contaminated organic waste containing chlorine, produced at the Marcoule Centre. The only valid method for these solvents of average activity is fractional distillation. This report presents a pilot fractional distillation plant designed for decontaminating the residual solvents produced by the Centre's Waste Processing Station. These contaminated solvents come from the decontamination of a screw extrusion apparatus with perchlorethylene; this equipment is used for coating the radioactive sludges with bitumen. The pilot plant operates discontinuously and is used to decontaminate the perchlorethylene, to separate the perchlorethylene from the water, and to process the distillation residue. The electrically heated boiler is fitted with a removable base in the form of a disposable container. The installations decontamination factor is 3.4 x 10{sup 6} when solvents with a specific activity of 0.23 Ci/m{sup 3} are used. The average flow-rate for a distillation run is 10 l/hr at atmospheric pressure, and 21 l/hr at a residual pressure of 40 torr. The decontamination factor for the installation is better at atmospheric pressure than in a vacuum. (authors) [French] Les effluents organiques contamines chlores du Centre de Marcoule ne peuvent etre incineres. Le seul mode de traitement qui s'impose pour ces solvants de moyenne activite s'avere etre la distillation fractionnee. Ce rapport presente une installation pilote de distillation fractionnee qui a ete concue pour decontaminer des solvants residuaires provenant de la Station de Traitement des Effluents du Centre. Ces solvants contamines resultent de la decontamination au moyen de perchlorethylene d'une extrudeuse a vis servant a l'enrobage par le bitume des boues radioactives de cette station. L'installation pilote fonctionne en discontinu et assure a la fois la decontamination du perchlorethylene, la separation du perchlorethylene et de l'eau et le

  5. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS...

  6. Les Brulures Chimiques Par Le Laurier Rose

    Science.gov (United States)

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Summary Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose de gravité différente. Cela doit aboutir à une information élargie de la population, ainsi qu'une réglementation stricte de sa commercialisation. PMID:21991211

  7. Les Brulures Chimiques Par Le Laurier Rose

    OpenAIRE

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose ...

  8. Deltagerinvolveret organisationsudvikling med PAR som metode

    DEFF Research Database (Denmark)

    Sparre, Mogens

    2017-01-01

    resistant to change. The quite widespread narrative of resistance to change, is believed to originate from the many top-down driven change projects implemented by the top management or/and external consultants. Is it possible to create a desired change in the form of the inter-subjective perception building......When a leader wants to initiate or influence some necessary changes in the organization, he must be aware of the fact that the subjects that form the organization create their own meaning about actions the manager wants implemented. This article confronts the assumption that people are by nature...... about the organization in an management group with a Participatory Action Research (PAR) case study? The article deals with a Phenomenological case study, where the researcher, with a PAR approach method, creates a research design with the purpose to influence the participant’s “Subjective perception...

  9. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  10. Ingenierie de nanoparticules plasmoniques robustes pour la generation de bulles par laser en vue d'applications biomedicales

    Science.gov (United States)

    Lachaine, Remi

    Les chirurgiens generent des bulles dans le corps humain a l'aide d'irradiation laser depuis plusieurs decennies. Ils utilisent ces bulles comme de petits scalpels, leur permettant de faire des incisions precises et localisees. Une des applications de cet outil chirurgical est la perforation cellulaire. Au lieu d'utiliser une aiguille pour perforer la membrane des cellules, il est possible de focaliser des impulsions laser en surface d'une cellule, formant un plasma au point focal du laser et generant une bulle qui perfore la membrane cellulaire. Toutefois, ce procede est assez lent et la perforation massive de cellules in-vivo n'est pas envisageable. Pour accelerer le processus, il est possible d'utiliser des nanoparticules plasmoniques. Ces dernieres agissent comme des nano-antennes qui permettent de concentrer la lumiere sur une echelle nanometrique. La possibilite d'irradier un grand nombre de nanoparticules simultanement a donne un nouvel elan a la generation de bulle comme outil de perforation cellulaire. L'utilisation de nanoparticules dans un contexte biomedical comporte toutefois certains risques. En particulier, la fragmentation de nanoparticules peut augmenter la toxicite du traitement. Dans un cas ideal, il est preferable d'utiliser des nanoparticules qui ne sont pas endommagees par l'irradiation laser. Cette these a pour but de developper une methode d'ingenierie de nanoparticules robustes permettant la generation efficace de bulles a des fins biomedicales. Il est tout d'abord demontre experimentalement que la formation de plasma est bel et bien le mecanisme physique principal menant a la generation de bulles lors de l'irradiation infrarouge (longueur d'onde de 800 nm) et ultrarapide (temps d'impulsion entre 45 fs et 1 ps) de nanoparticules d'or de 100 nm. Pour realiser cette demonstration, une methode pompe-sonde de detection de bulles d'environ 1 mum a ete elaboree. Cette methode a permis de mettre en evidence une difference de taille de 18% entre

  11. Methode d'identification parametrique pour la surveillance in situ des joints a recouvrement par propagation d'ondes vibratoires

    Science.gov (United States)

    Francoeur, Dany

    Cette these de doctorat s'inscrit dans le cadre de projets CRIAQ (Consortium de recherche et d'innovation en aerospatiale du Quebec) orientes vers le developpement d'approches embarquees pour la detection de defauts dans des structures aeronautiques. L'originalite de cette these repose sur le developpement et la validation d'une nouvelle methode de detection, quantification et localisation d'une entaille dans une structure de joint a recouvrement par la propagation d'ondes vibratoires. La premiere partie expose l'etat des connaissances sur l'identification d'un defaut dans le contexte du Structural Health Monitoring (SHM), ainsi que la modelisation de joint a recouvrements. Le chapitre 3 developpe le modele de propagation d'onde d'un joint a recouvrement endommage par une entaille pour une onde de flexion dans la plage des moyennes frequences (10-50 kHz). A cette fin, un modele de transmission de ligne (TLM) est realise pour representer un joint unidimensionnel (1D). Ce modele 1D est ensuite adapte a un joint bi-dimensionnel (2D) en faisant l'hypothese d'un front d'onde plan incident et perpendiculaire au joint. Une methode d'identification parametrique est ensuite developpee pour permettre a la fois la calibration du modele du joint a recouvrement sain, la detection puis la caracterisation de l'entaille situee sur le joint. Cette methode est couplee a un algorithme qui permet une recherche exhaustive de tout l'espace parametrique. Cette technique permet d'extraire une zone d'incertitude reliee aux parametres du modele optimal. Une etude de sensibilite est egalement realisee sur l'identification. Plusieurs resultats de mesure sur des joints a recouvrements 1D et 2D sont realisees permettant ainsi l'etude de la repetabilite des resultats et la variabilite de differents cas d'endommagement. Les resultats de cette etude demontrent d'abord que la methode de detection proposee est tres efficace et permet de suivre la progression d'endommagement. De tres bons resultats

  12. étude par AFM dynamique.

    African Journals Online (AJOL)

    user

    Ces forces oscillatoires de solvatation sont carac- térisées par une augmentation en amplitude lorsque la distance de confinement diminue (en tendant vers zéro), la périodicité des oscillations étant approximativement égales au diamètre des molécules du liquide confiné. Dans ce travail, nous sommes partis des récents ...

  13. Proteinase-activated receptors (PARs) as targets for antiplatelet therapy.

    Science.gov (United States)

    Cunningham, Margaret; McIntosh, Kathryn; Bushell, Trevor; Sloan, Graeme; Plevin, Robin

    2016-04-15

    Since the identification of the proteinase-activated receptor (PAR) family as mediators of serine protease activity in the 1990s, there has been tremendous progress in the elucidation of their pathophysiological roles. The development of drugs that target PARs has been the focus of many laboratories for the potential treatment of thrombosis, cancer and other inflammatory diseases. Understanding the mechanisms of PAR activation and G protein signalling pathways evoked in response to the growing list of endogenous proteases has yielded great insight into receptor regulation at the molecular level. This has led to the development of new selective modulators of PAR activity, particularly PAR1. The mixed success of targeting PARs has been best exemplified in the context of inhibiting PAR1 as a new antiplatelet therapy. The development of the competitive PAR1 antagonist, vorapaxar (Zontivity), has clearly shown the value in targeting PAR1 in acute coronary syndrome (ACS); however the severity of associated bleeding with this drug has limited its use in the clinic. Due to the efficacy of thrombin acting via PAR1, strategies to selectively inhibit specific PAR1-mediated G protein signalling pathways or to target the second thrombin platelet receptor, PAR4, are being devised. The rationale behind these alternative approaches is to bias downstream thrombin activity via PARs to allow for inhibition of pro-thrombotic pathways but maintain other pathways that may preserve haemostatic balance and improve bleeding profiles for widespread clinical use. This review summarizes the structural determinants that regulate PARs and the modulators of PAR activity developed to date. © 2016 Authors; published by Portland Press Limited.

  14. Etude du mecanisme de predissociation de l'ion moleculaire de protoxyde d'azote par la mesure de l'energie cinetique des fragments de l'oxyde nitrique et de l'oxygene

    Science.gov (United States)

    Delisle, Claude

    La reaction N2 + O+ ↔ NO + + N, laquelle joue un role important dans la physique de la haute atmosphere, a ete le sujet de plusieurs etudes. Bien que cette reaction ait ete l'objet d'une quantite importante de travaux, ces derniers ne permettent toutefois pas de comprendre entierement le mecanisme d'un point de vue quantique, particulierement les niveaux d'energie excites des fragments qui permettent cette reaction. Puisque cette reaction n'est pas tres facile a reproduire en laboratoire, nous avons utilise la spectroscopie laser sur faisceaux d'ions rapides afin d'explorer les limites de dissociation de l'ion moleculaire intermediaire de cette reaction, a savoir l'ion N2O+. Le faisceau d'ions N2O+ rapides, apres excitation de l'ion moleculaire vers un niveau predissocie de l'etat A2Sigma+, se dissocie pour produire les fragments ioniques O+ et NO+. Par la mesure de la variation du nombre de fragments ioniques en fonction de l'energie cinetique des ions N2O+, nous avons enregistre les spectres de predissociation de l'ion N2O+. Lorsque c'etait possible, nous avons procede a l'analyse de ces spectres de dissociation afin d'en tirer les constantes moleculaires. Pour certaines des transitions rotationnelles intenses, nous avons mesure l'energie cinetique acquise par les fragments lors de la predissociation de l'ion N 2O+. Afin d'analyser les distributions en energie cinetique, nous avons developpe une simulation de l'experience en considerant, entre autres choses, la position des niveaux de vibration et de rotation des fragments diatomiques de chacune des limites de dissociation de N2O+. Les resultats de l'analyse sont exprimes en termes de population des niveaux de vibration des fragments diatomiques pour une distribution donnee de la population des niveaux de rotation des fragments. Les resultats ainsi obtenus, montrent que les fragments diatomiques sont produits dans des niveaux de vibration fortement excites. De tels niveaux d'excitation ne correspondent pas aux

  15. Use of a thin-film evaporator for bitumen coating of radioactive concentrates; Utilisation d'un evaporateur a couche mince pour l'enrobage par le bitume de concentrats radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Lefillatre, G.; Rodier, J.; Hullo, R.; Cudel, Y.; Rodi, L. [Commissariat a l' Energie Atomique, Chusclan (France). Centre de Production de Plutonium de Marcoule

    1969-07-01

    Following the development in the laboratory of a process for coating evaporation concentrates with bitumen, a technological study of this coating process has been undertaken. The report describes a pilot installation for the bitumen coating of concentrates, which uses a thin-film evaporator LUWA L 150. The first, inactive series of tests was designed to determine the maximum and optimum capacities of the evaporator by varying the amounts of bitumen and of concentrate, the rotor speed and the thermo-fluid temperature. Two rotors were tested, one of conventional type, the other a model especially designed for high viscosity products. The maximum capacity of evaporation of the apparatus is 72 kg/hr for a heating temperature of 221 deg. C. During normal operation, the evaporator can produce 50 kg/hr of coated product containing 55 to 60 per cent of bitumen (Mexphalte 40/50), the water content of the product remaining under 0.5 per cent. A second series of tests will shortly be carried out on this pilot installation using, in particular, bituminous emulsions containing mainly Mexphalte 40/50 and 80/100. (authors) [French] A la suite de la mise au point en laboratoire d'un procede d'enrobage par le bitume de concentrats d'evaporation, une etude technologique de cet enrobage a ete entreprise. Ce rapport decrit une installation pilote d'enrobage par le bitume de concentrats utilisant un evaporateur a couche mince LUWA L 150. La premiere serie d'essais en inactif a eu pour but de definir les capacites maximales et optimales de l'evaporateur en faisant varier les dosages en bitume et en concentrats, la vitesse du rotor et la temperature du thermo-fluide. Deux rotors ont ete testes, l'un de type classique, l'autre d'un modele special concu pour les produits de haute viscosite. La capacite d'evaporation maximale de l'appareil est de 72 kg/h d'eau pour une temperature de chauffage de 221 deg. C. En marche normale l

  16. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  17. Diagnosis of Parietaria judaica pollen allergy using natural and recombinant Par j 1 and Par j 2 allergens.

    Science.gov (United States)

    González-Rioja, R; Ferrer, A; Arilla, M C; Ibarrola, I; Viguera, A R; Andreu, C; Martínez, A; Asturias, J A

    2007-02-01

    Parietaria judaica pollen is one of the main causes of allergic diseases in the Mediterranean area and contains two major allergens, called Par j 1 and Par j 2. To evaluate the diagnostic potential of natural and recombinant forms of Par j 1 and Par j 2 in comparison with standardized P. judaica pollen extract. Thirty patients allergic to P. judaica pollen and 15 control patients were investigated. Skin prick tests and determination of specific IgE levels were performed with commercial P. judaica extract, natural Par j 1 and Par j 2, and recombinant forms of both allergens expressed in P. pastoris. The whole group of patients with allergy to P. judaica had a positive skin test reaction to purified nPar j 1-Par j 2 and rPar j 2 at 5 microg/mL, and no false-positive reactions were detected. Natural and recombinant Par j 1 and Par j 2 showed no significantly different responses in skin tests compared with P. judaica extract. A high correlation was found between the serum-specific IgE levels to P. judaica extract vs. natural (R=0.996; P<0.001) and recombinant allergens (R=0.887 and 0.982 for rPar j 1 and rPar j 2, respectively; P<0.001). rPar j 2 displayed a 100% sensitivity and specificity among P. judaica-allergic patients. In vivo and in vitro diagnosis of P. judaica pollen allergy could be simplified using rPar j 2. This protein showed comparable IgE response and skin prick reactivity with those produced by P. judaica pollen extract.

  18. Contribution to the study of detonation initiation by shock in solid explosives (1961); Contribution a l'etude de l'initiation de la detonation par choc dans les explosifs solides (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Fauquignon, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-05-15

    When a shock wave is induced in an explosive, it can initiate chemical reactions which lead more or less rapidly to a stable detonation state. In this study more particular attention was paid to the transition phase, in which has been evaluated the increases in the wave velocity, the pressure, and the electrical conductivity. The influence of the nature of the medium in front of the wave and in contact with the explosive has also been the subject of an experimental study designed to determine the extent to which its nature can be ignored and, subsequently, to characterise the initiation conditions using only the shock intensity induced in the explosive. Finally, the results were generalized for various explosive compositions and led to the development of a possible mechanism for shock initiation. (author) [French] Lorsqu'une onde de choc est induite dans un explosif, elle peut y amorcer des reactions chimiques qui conduisent plus ou moins rapidement a un regime de detonation stable. Dans cette etude, on s'est interesse plus particulierement a la phase transitoire dans laquelle on a evalue l'accroissement de la vitesse d'onde, de la pression et de la conductibilite electrique. L'influence du milieu amont, au contact de l'explosif, a egalement fait l'objet de recherches experimentales de facon a determiner dans quelle mesure on pouvait s'affranchir de sa nature et, par suite, caracteriser les conditions d'initiation par la seule intensite du choc induit dans l'explosif. Enfin, les resultats ont ete generalises a diverses compositions explosives et ont conduit a l'elaboration d'un schema possible du mecanisme de l'initiation par choc. (auteur)

  19. A single parS sequence from the cluster of four sites closest to oriC is necessary and sufficient for proper chromosome segregation in Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Paulina Jecz

    Full Text Available Among the mechanisms that control chromosome segregation in bacteria are highly-conserved partitioning systems comprising three components: ParA protein (a deviant Walker-type ATPase, ParB protein (a DNA-binding element and multiple cis-acting palindromic centromere-like sequences, designated parS. Ten putative parS sites have been identified in the P. aeruginosa PAO1 genome, four localized in close proximity of oriC and six, diverged by more than one nucleotide from a perfect palindromic sequence, dispersed along the chromosome. Here, we constructed and analyzed P. aeruginosa mutants deprived of each single parS sequence and their different combinations. The analysis included evaluation of a set of phenotypic features, chromosome segregation, and ParB localization in the cells. It was found that ParB binds specifically to all ten parS sites, although with different affinities. The P. aeruginosa parS mutant with all ten parS sites modified (parSnull is viable however it demonstrates the phenotype characteristic for parAnull or parBnull mutants: slightly slower growth rate, high frequency of anucleate cells, and defects in motility. The genomic position and sequence of parS determine its role in P. aeruginosa biology. It transpired that any one of the four parS sites proximal to oriC (parS1 to parS4, which are bound by ParB with the highest affinity, is necessary and sufficient for the parABS role in chromosome partitioning. When all these four sites are mutated simultaneously, the strain shows the parSnull phenotype, which indicates that none of the remaining six parS sites can substitute for these four oriC-proximal sites in this function. A single ectopic parS2 (inserted opposite oriC in the parSnull mutant facilitates ParB organization into regularly spaced condensed foci and reverses some of the mutant phenotypes but is not sufficient for accurate chromosome segregation.

  20. A single parS sequence from the cluster of four sites closest to oriC is necessary and sufficient for proper chromosome segregation in Pseudomonas aeruginosa.

    Science.gov (United States)

    Jecz, Paulina; Bartosik, Aneta A; Glabski, Krzysztof; Jagura-Burdzy, Grazyna

    2015-01-01

    Among the mechanisms that control chromosome segregation in bacteria are highly-conserved partitioning systems comprising three components: ParA protein (a deviant Walker-type ATPase), ParB protein (a DNA-binding element) and multiple cis-acting palindromic centromere-like sequences, designated parS. Ten putative parS sites have been identified in the P. aeruginosa PAO1 genome, four localized in close proximity of oriC and six, diverged by more than one nucleotide from a perfect palindromic sequence, dispersed along the chromosome. Here, we constructed and analyzed P. aeruginosa mutants deprived of each single parS sequence and their different combinations. The analysis included evaluation of a set of phenotypic features, chromosome segregation, and ParB localization in the cells. It was found that ParB binds specifically to all ten parS sites, although with different affinities. The P. aeruginosa parS mutant with all ten parS sites modified (parSnull) is viable however it demonstrates the phenotype characteristic for parAnull or parBnull mutants: slightly slower growth rate, high frequency of anucleate cells, and defects in motility. The genomic position and sequence of parS determine its role in P. aeruginosa biology. It transpired that any one of the four parS sites proximal to oriC (parS1 to parS4), which are bound by ParB with the highest affinity, is necessary and sufficient for the parABS role in chromosome partitioning. When all these four sites are mutated simultaneously, the strain shows the parSnull phenotype, which indicates that none of the remaining six parS sites can substitute for these four oriC-proximal sites in this function. A single ectopic parS2 (inserted opposite oriC in the parSnull mutant) facilitates ParB organization into regularly spaced condensed foci and reverses some of the mutant phenotypes but is not sufficient for accurate chromosome segregation.

  1. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis......-acting region of approximately 200 bp, called parC1, located between the two par loci. An additional cis-acting region, parC2, is located downstream of the parAB operon of par2. Here we show that ParR of par1 and ParB of par2 bind cooperatively to unrelated sets of direct repeats in parC1 to form the cognate...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  2. Dilatometric, radio crystallographic, and microstructural study of transformations produced by quenching at different rates with subsequent tempering, in zirconium-copper alloys containing less than 5 per cent copper by weight; Etude dilatometrique, radiocristallographique et microstructurale des transformations par trempe a diverses vitesses et par revenu ulterieur des alliages Zr-Cu a faibles teneurs (inferieures a 5 pour cent poids)

    Energy Technology Data Exchange (ETDEWEB)

    Couterne, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-03-01

    When {beta}-phase zirconium-copper alloys are strongly tempered, structural transformations occur leading to metastable phases which are not predicted by the equilibrium diagram. The formation mechanism is always of the martensitic type but the crystalline structures are very different according to the amount of the added element: - when the copper content is about 1 per cent by weight, a hexagonal {alpha}' phase is obtained having parameters which are very close to those of the a solid solution; its morphology is strongly acicular. - when the copper content is equal or greater than 1.6 per cent Cu by weight, a new {omega} phase has been shown to exist; this phase has a hexagonal symmetry (c/a = 0.624) and the crystals formed are of sub-microscopic size. This {omega} phase is decomposed on isothermal or an-isothermal tempering, probably by shearing, at a temperature which is practically below 550 C; an {alpha} supersaturated solid solution is first formed and there then occurs a gradual change to the a equilibrium solid solution with progressive precipitation of the compound Zr{sub 2}Cu. (author) [French] Par trempe energique depuis la phase {beta}, les alliages zirconium-cuivre sont le siege de transformations structurales conduisant a des phases metastables non prevues par le diagramme d'equilibre. Le mecanisme de formation est toujours de type martensitique, mais suivant la teneur en element ajoute les structures cristallines evoluent nettement: - lorsque la teneur en cuivre est de l'ordre de 1 pour cent Cu pds, on obtient une phase {alpha}' hexagonale, de parametres voisins de ceux de la solution solide {alpha}, et dont la morphologie est nettement aciculaire; - lorsque la teneur en cuivre est egale ou superieure a 1.6 pour cent Cu pds, une nouvelle phase {omega} a ete mise en evidence; cette phase a une symetrie hexagonale (c/a 0.624) et les cristaux formes sont de taille submicroscopique. Par revenu isotherme ou anisotherme cette phase

  3. Apport maternel chez la balane tropicale : Plasticite de l'allocation de la ressource trophique pour la production larvaire en conditions de limitation nutritionnelle et de stress environnemental

    Science.gov (United States)

    Freuchet, Florian

    Dans le milieu marin, l'abondance du recrutement depend des processus qui vont affecter les adultes et le stock de larves. Sous l'influence de signaux fiables de la qualite de l'habitat, la mere peut augmenter (effet maternel anticipatoire, 'anticipatory mother effects', AME) ou reduire (effet maternel egoiste, 'selfish maternai effects', SME) la condition physiologique de la progeniture. Dans les zones tropicales, generalement plus oligotrophes, la ressource nutritive et la temperature sont deux composantes importantes pouvant limiter le recrutement. Les effets de l'apport nutritionnel et du stress thermique sur la production de larves et sur la stategie maternelle adoptee ont ete testes dans cette etude. Nous avons cible la balane Chthamalus bisinuatus (Pilsbry) comme modele biologique car el1e domine les zones intertidales superieures le long des cotes rocheuses du Sud-Est du Bresil (region tropicale). Les hypotheses de depart stipulaient que l'apport nutritionnel permet aux adultes de produire des larves de qualite elevee et que le stress thermique genere une ponte precoce, produisant des larves de faible qualite. Afin de tester ces hypotheses, des populations de C. bisinuatus ont ete elevees selon quatre groupes experimentaux differents, en combinant des niveaux d'apport nutritionnel (eleve et faible) et de stress thermique (stresse et non stresse). Des mesures de survie et de conditions physiologiques des adultes et des larves ont permis d'identifier les reponses parentales pouvant etre avantageuses dans un environnement tropical hostile. L'analyse des profils en acides gras a ete la methode utilisee pour evaluer la qualite physiologique des adultes et de larves. Les resultats du traitement alimentaire (fort ou faible apport nutritif), ne montrent aucune difference dans l'accumulation de lipides neutres, la taille des nauplii, l'effort de reproduction ou le temps de survie des nauplii en condition de jeune. Il semble que la faible ressource nutritive est

  4. Cataract surgery after pars plana vitrectomy.

    Science.gov (United States)

    Shousha, Mohamed Abou; Yoo, Sonia H

    2010-01-01

    To review recent studies and advances and their possible implications in the care of patients undergoing cataract surgery after pars plana vitrectomy. Optical biometry has shown to be superior to ultrasound biometry in vitrectomized eyes but still not achieving as good results as it does in nonvitrectomized eyes. Blue light-filter intraocular lenses, with their possible advantage of macular protection, have shown no operative or functional disadvantages in vitrectomized eyes, and thus their routine use can be justified. However, presbyopia-correcting intraocular lenses, at least at their current stage of development, generally, are still not accepted for vitrectomized eyes. Combining cataract surgery with intravitreal injections of bevacizumab or triamcinolone acetonide in patients with macular edema and cataract is advisable to avoid exacerbation of the condition and improve visual outcome. Despite the recent advances, incidences of posterior capsular opacification and retinal detachment are still considerable. Understanding ocular anatomical alterations imposed by the previous pars plana vitrectomy surgery and the underlying vitreoretinal disease will allow the surgeon to address the special challenges. Despite that, recent advances in techniques and instrumentation have improved the surgical safety and outcomes, reported complications rates are still relatively high.

  5. A Par-1-Par-3-Centrosome Cell Polarity Pathway and Its Tuning for Isotropic Cell Adhesion.

    Science.gov (United States)

    Jiang, Tao; McKinley, R F Andrew; McGill, Melanie A; Angers, Stephane; Harris, Tony J C

    2015-10-19

    To form regulated barriers between body compartments, epithelial cells polarize into apical and basolateral domains and assemble adherens junctions (AJs). Despite close links with polarity networks that generate single polarized domains, AJs distribute isotropically around the cell circumference for adhesion with all neighboring cells [1-3]. How AJs avoid the influence of polarity networks to maintain their isotropy has been unclear. In established epithelia, trans cadherin interactions could maintain AJ isotropy [4], but AJs are dynamic during epithelial development and remodeling [5, 6], and thus specific mechanisms may control their isotropy. In Drosophila, aPKC prevents hyper-polarization of junctions as epithelia develop from cellularization to gastrulation [7]. Here, we show that aPKC does so by inhibiting a positive feedback loop between Bazooka (Baz)/Par-3, a junctional organizer [5, 8-10], and centrosomes. Without aPKC, Baz and centrosomes lose their isotropic distributions and recruit each other to single plasma membrane (PM) domains. Surprisingly, our loss- and gain-of-function analyses show that the Baz-centrosome positive feedback loop is driven by Par-1, a kinase known to phosphorylate Baz and inhibit its basolateral localization [8, 11, 12]. We find that Par-1 promotes the positive feedback loop through both centrosome microtubule effects and Baz phosphorylation. Normally, aPKC attenuates the circuit by expelling Par-1 from the apical domain at gastrulation. The combination of local activation and global inhibition is a common polarization strategy [13-16]. Par-1 seems to couple both effects for a potent Baz polarization mechanism that is regulated for the isotropy of Baz and AJs around the cell circumference. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. The PAR Proteins: Fundamental Players in Animal Cell Polarization

    OpenAIRE

    Goldstein, Bob; Macara, Ian G.

    2007-01-01

    The par genes were discovered in genetic screens for regulators of cytoplasmic partitioning in the early embryo of C. elegans, and encode six different proteins required for asymmetric cell division by the worm zygote. Some of the PAR proteins are localized asymmetrically and form physical complexes with one another. Strikingly, the PAR proteins have been found to regulate cell polarization in many different contexts in diverse animals, suggesting they form part of an ancient and fundamental ...

  7. Parálisis cerebral Cerebral palsy

    OpenAIRE

    Jorge Malagon Valdez

    2007-01-01

    El término parálisis cerebral (PC) engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia me...

  8. Improvements to the properties of uranium by addition of small quantities of other metals; Ameliorations apportees a l'uranium par de faibles additions metalliques

    Energy Technology Data Exchange (ETDEWEB)

    Englander, M. [Commissariat a l' Energie Atomique, Saclay (France).Centre d' Etudes Nucleaires

    1960-07-01

    enrichi en isotope U{sup 235}. Dans les conditions optimales de fonctionnement, un meme materiau combustible doit alors fournir un minimum de 3000 MWj/t, soit 72.10{sup 6} kWh par tonne d'uranium naturel, tout en etant porte a une temperature suffisante pour jouer efficacement son role de source de chaleur (entre 350 et 550 deg. C minimum). Or d'une facon assez surprenante, les agregats polycristallins des billettes d'uranium obtenues par coulee sous vide, ou apres filage a haute temperature, se presentent comme un ensemble de grains tres grossiers, a contours dechiquetes et irreguliers, et comportent de nombreuses marques de deformation intragranulaire (macles, lignes de glissement), accompagnees de fortes sous-structures. En plus, le spectre de la dimension des grains s'etend de quelques microns a quelques millimetres, selon les plages micrographiques examinees. Sous irradiation a ces temperatures, l'uranium metallique pur en barreaux cylindriques de diametre de l'ordre du pouce, se deforme: il se produit des fissures dans la masse, des variations de dimensions longitudinales et transversales (qui se traduisent par des peaux d'orange), soit par croissances plus ou moins directionnelles, soit par deformations superficielles qui peuvent provoquer des ruptures du materiau, de sa gaine ou des fleches suffisamment importantes pour obstruer les canaux de refroidissement. Il a ete reconnu par la suite que cette instabilite, sous l'effet des contraintes thermiques d'origine nucleaire, est due a la morphologie heterogene de l'uranium et a sa structure cristalline anisotrope (U{sub {alpha}} ou U{sub {beta}}). (auteur)

  9. Scattering of electromagnetic waves by an non-uniform cylindrical plasma; Diffusion coherente d'une onde electromagnetique par un cylindre de plasma inhomogene

    Energy Technology Data Exchange (ETDEWEB)

    Faugeras, P.E. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires. Groupe de recherches sur la fusion controlee

    1967-07-01

    incidente cylindrique (surfaces d'onde paralleles a l'axe du cylindre). Ceci permet de relier les resultats theoriques aux diagrammes de diffraction experimentaux, et aussi d'expliquer les phenomenes, de diffraction qui faussent l'interpretation des mesures par interferometrie hyperfrequence. Ces resultats, joints a la possibilite de mesurer exactement le champ diffracte (ce que nous avons montre avec des cylindres dielectriques et metalliques) conduisent a une nouvelle methode de diagnostic d'un plasma, basee sur la diffraction. Sans limitations theoriques, cette methode est applicable la ou les methodes hyperfrequences classiques ne le sont pas (diametre du plasma inferieur a 10 longueurs d'onde).Cette methode a ete experimentee sur plasma a la pression atmospherique, avec une onde incidente de 2 mm. Le plasma est engendre par le jet laminaire d'une torche a plasma, fonctionnant avec de l'helium ou de l'argon ensemence au potassium (la densite peut ainsi varier de facon continue entre 10{sup 11} et 10{sup 15} e/cm{sup 3}). On donne egalement quelques diagrammes de diffraction par ce plasma, releves pour differents champs incidents, et interpretes par les resultats theoriques precedents. (auteur)

  10. Development of a 'chronotron' for time of flight fast neutron spectrometer; Realisation d'un chronotron pour spectrometre a neutrons rapides par temps de vol

    Energy Technology Data Exchange (ETDEWEB)

    Duclos, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-10-15

    A chronotron using storage circuits of a 100 channels amplitude analyser has been developed in order to measure the time of flight of fast neutrons. A time dilatation is obtained by a distribution of 20 6BN6 tubes. The width at half maximum of prompt coincidences curve is 1,6.10{sup -9} s for {beta}-{gamma} coincidences from An{sup 198} and 2.10{sup -9} s for n-{alpha} coincidences from (d, t) reaction. (author) [French] En vue de realiser un spectrometre a neutrons rapides par temps de vol, un chronotron utilisant les circuits d'enregistrement d'un selecteur d'amplitude de 100 canaux a ete construit. Une dilatation du temps est obtenue a l'aide d'une distribution de 20 lampes 6BN6. La largeur a mi-hauteur de la courbe de resolution est 1,6.10{sup -9} s pour les coincidences {beta}-{gamma} de Au{sup 198} et 2.10{sup -9} s pour les coincidences n-{alpha} de la reaction (d, t). (auteur)

  11. Determination of local boiling in light water reactors by correlation of the neutron noise; Determination de l'ebullition locale dans les reacteurs a eau legere par correlation du bruit neutronique

    Energy Technology Data Exchange (ETDEWEB)

    Zwingelstein, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1968-07-01

    The power limit of swimming-pool type reactors depends on the phenomenon of the appearance of burn-out. In order to determine this limit we have attempted to detect the local boiling which usually occurs before the burn out. Local boiling has been simulated by an electrically heated plate placed in the core of the reactor Siloette. The study of local boiling, which is based on the properties of the correlation functions for the neutron noise of detectors placed in the core, shows that a privileged frequency occurs in the power spectrum of the noise. It is intended in the future to determine the influence of various parameters on this characteristic frequency. (author) [French] La limitation de la puissance des reacteurs nucleaires de type piscine est due au phenomene d'apparition de 'burn out'. Pour determiner cette limitation, nous nous sommes proposes dans ce rapport de detecter l'ebullition locale qui apparait generalement avant le 'burn out'. L'ebullition locale a ete simulee par une plaque chauffee electriquement et placee dans le coeur du reacteur SILOETTE. L'etude de l'ebullition locale, qui est basee sur les proprietes des fonctions de correlation du bruit neutronique de detecteurs places clans le coeur, fait apparaitre une frequence privilegiee dans le spectre de puissance du bruit. On envisage dans l'avenir, de determiner l'influence des divers parametres sur cette frequence caracteristique. (auteur)

  12. Recherche des oscillations de Neutrinos $\

    CERN Document Server

    Gangler, E

    1997-01-01

    Le detecteur nomad, place sur le faisceau de neutrinos wide-band-beam du sps, de contamination en neutrino tau marginale, permet de rechercher des oscillations neutrino muon - tau dans la region de pertinence cosmologique et de distinguer statistiquement les courants charges des neutrinos tau essentiellement par leur mesure cinematique. Une large part du travail de these a donc ete consacree a la reconstruction des evenements dans les chambres a derive, cible instrumentee et cur de l'experience, dont la physique de detection est decrite. Une methode de recherche de traces fut developpee, utilisant certaines informations d'un autre sous-detecteur de nomad, le trd. Pour combler une perte d'efficacite de reconstruction, une methode de recherche de traces courtes s'appuyant sur des vertex deja constitues fut developpee en exploitant les potentialites du filtre de kalman, algorithme iteratif d'ajustement de traces. Ces methodes sont utilisees en production par la collaboration. Cette these porte sur la recherche d...

  13. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  14. Transcriptome profiling reveals links between ParS/ParR, MexEF-OprN, and quorum sensing in the regulation of adaptation and virulence in Pseudomonas aeruginosa.

    Science.gov (United States)

    Wang, Dongping; Seeve, Candace; Pierson, Leland S; Pierson, Elizabeth A

    2013-09-13

    The ParS/ParR two component regulatory system plays critical roles for multidrug resistance in Pseudomonas aeruginosa. It was demonstrated that in the presence of antimicrobials, ParR enhances bacterial survival by distinct mechanisms including activation of the mexXY efflux genes, enhancement of lipopolysaccharide modification through the arn operon, and reduction of the expression of oprD porin. In this study, we report on transcriptomic analyses of P. aeruginosa PAO1 wild type and parS and parR mutants growing in a defined minimal medium. Our transcriptomic analysis provides the first estimates of transcript abundance for the 5570 coding genes in P. aeruginosa PAO1. Comparative transcriptomics of P. aeruginosa PAO1 and par mutants identified a total of 464 genes regulated by ParS and ParR. Results also showed that mutations in the parS/parR system abolished expression of the mexEF-oprN operon by down-regulating the regulatory gene mexS. In addition to the known effects on drug resistance genes, transcript abundances of the quorum sensing genes (rhlIR and pqsABCDE-phnAB) were higher in both parS and parR mutants. In accordance with these results, a significant portion of the ParS/ParR regulated genes belonged to the MexEF-OprN and quorum sensing regulons. Deletion of the par genes also led to increased phenazine production and swarming motility, consistent with the up-regulation of the phenazine and rhamnolipid biosynthetic genes, respectively. Our results link the ParS/ParR two component signal transduction system to MexEF-OprN and quorum sensing systems in P. aeruginosa. These results expand our understanding of the roles of the ParS/ParR system in the regulation of gene expression in P. aeruginosa, especially in the absence of antimicrobials.

  15. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    Bacterial plasmids encode partitioning (par) loci that confer stable plasmid inheritance. We showed previously that, in the presence of ParB and parC encoded by the par2 locus of plasmid pB171, ParA formed cytoskeletal-like structures that dynamically relocated over the nucleoid. Simultaneously, ...... of the plasmids. Mathematical modeling of ParA and plasmid dynamics support these interpretations. Mutational analysis supports a molecular mechanism in which the ParB/parC complex controls ParA filament depolymerization....

  16. Pratique du bloc infraclaviculaire par voie sous coracoïdienne par ...

    African Journals Online (AJOL)

    Toutefois, des efforts pour réduire le temps de réalisation, choisir la meilleure réponse motrice distale sur laquelle injecter l'anesthésique local, par une pratique plus fréquente des techniques d'ALR périphérique, sont nécessaires pour augmenter le confort des patients et le taux de succès du bloc. Mots clés: Anesthésie ...

  17. Combined pars plana vitrectomy and pars plana Baerveldt tube placement in eyes with neovascular glaucoma.

    Science.gov (United States)

    Kolomeyer, Anton M; Seery, Christopher W; Emami-Naeimi, Parisa; Zarbin, Marco A; Fechtner, Robert D; Bhagat, Neelakshi

    2015-01-01

    To describe characteristics and outcomes of combined pars plana vitrectomy and Baerveldt tube insertion procedure from 2005 to 2010 in eyes with neovascular glaucoma. Seventy-nine patients (89 eyes) with ≥2 months of follow-up were included. Outcome measures were visual acuity, intraocular pressure (IOP), number of glaucoma medications, and complications. Changes in mean logMAR visual acuity, IOP, and glaucoma medications were compared by a two-tailed t-test. Mean patient age was 69.0 years. Forty-three (54%) were male. Mean follow-up time was 19.9 months. Most common causes of neovascular glaucoma was diabetes (n = 63 [71%]) and central retinal vein occlusion (n = 21 [24%]). Eighty-six eyes (97%) underwent a 250 mm Baerveldt drainage device and 3 (3.4%) a 350 mm Baerveldt. Forty-five (51%) 20-gauge, 12 (13%) 23-gauge, and 32 (36%) 25-gauge pars plana vitrectomies were performed. Fifty-two eyes (58%) preoperatively and 23 (33%) postoperatively received intraocular injections for rubeosis and macular edema. Mean ± standard deviation logMAR visual acuity at 18-, 24-, 36-, and 48-month follow-up time points was significantly better than preoperative vision (P pars plana vitrectomy eyes. Nine eyes (10%) required return to the operating room after combined procedure, including 4 eyes (4.5%) for retinal detachment and 3 (3.4%) for high IOP due to tube occlusion. Three eyes (3.4%) developed endophthalmitis and 2 (2.2%) progressed to being pre/phthisical (none were enucleated). Combined pars plana vitrectomy and Baerveldt glaucoma shunt may be a useful procedure in reducing IOP and number of glaucoma medications in eyes with neovascular glaucoma along with stabilizing visual acuity in a majority of these eyes. Further studies are warranted to verify and expand on these findings.

  18. Doxycycline directly targets PAR1 to suppress tumor progression.

    Science.gov (United States)

    Zhong, Weilong; Chen, Shuang; Zhang, Qiang; Xiao, Ting; Qin, Yuan; Gu, Ju; Sun, Bo; Liu, Yanrong; Jing, Xiangyan; Hu, Xuejiao; Zhang, Peng; Zhou, Honggang; Sun, Tao; Yang, Cheng

    2017-03-07

    Doxycycline have been reported to exert anti-cancer activity and have been assessed as anti-cancer agents in clinical trials. However, the direct targets of doxycycline in cancer cells remain unclear. In this study, we used a chemical proteomics approach to identify the Protease-activated receptor 1 (PAR1) as a specific target of inhibition of doxycycline. Binding assays and single-molecule imaging assays were performed to confirm the inhibition of doxycycline to PAR1. The effect of doxycycline on multi-omics and cell functions were assessed based on a PAR1/thrombin model. Molecular docking and molecular dynamic simulations revealed that doxycycline interacts with key amino acids in PAR1. Mutation of PAR1 further confirmed the computation-based results. Moreover, doxycycline provides highly selective inhibition of PAR1 signaling in tumors in vitro and in vivo. Using pathological clinical samples co-stained for doxycycline and PAR1, it was found that doxycycline fluorescence intensity and PAR1 expression shown a clear positive correlation. Thus, doxycycline may be a useful targeted anti-cancer drug that should be further investigated in clinical trials.

  19. Priapisme induit par la chlorpromazine: A propos de deux cas

    African Journals Online (AJOL)

    I. Marrag

    Nous rapportons ici le cas de deux patients qui ont présenté un priapisme en concomitance avec une pres- cription de chlorpromazine .... ischémiques pourraient être induits par des médicaments dont les neuroleptiques occupent ... vie sexuelle des patients, souvent touchée par la prescription des traitements psychotropes ...

  20. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells w...

  1. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  2. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  3. Megestrol acetate NCD oral suspension--Par Pharmaceutical: megestrol acetate nanocrystal dispersion oral suspension, PAR 100.2, PAR-100.2.

    Science.gov (United States)

    2007-01-01

    Par Pharmaceutical has developed megestrol acetate (Megace ES) oral suspension for the treatment of anorexia, cachexia and a significant weight loss associated with AIDS. Par Pharmaceutical used Elan Corporation's NanoCrystal Dispersion (NCD) technology to develop an advanced, concentrated formulation of megestrol acetate with improved bioavailability, more rapid onset of action, more convenient dosing and a lower dosing regimen compared with the original marketed formulation of megestrol acetate oral suspension. Patients are administered a teaspoon (5mL) of the new NCD formulation once daily, compared with a daily 20mL dosage cup of the original formulation. The new megestrol acetate NCD formulation represents a line-extension of Par's megestrol acetate oral suspension (800mg/20mL, Megace O/S) that has been marketed for anorexia, cachexia and AIDS-related weight loss since July 2001. Par's megestrol acetate is the generic version of Bristol-Myers Squibb's Megace Oral Suspension. NanoCrystal Dispersion (NCD) is a trademark of Elan Corporation. Par Pharmaceutical will market megestol acetate NCD oral suspension under the Megace brand name. The company licensed the Megace name from Bristol-Myers Squib in August 2003. The US FDA approved megestrol acetate oral suspension (625 mg/mL) in July 2005 for the treatment of anorexia, cachexia or a significant, unexplained weight loss in patients with AIDS. The NDA for the product was accepted for review by the agency in September 2004, following its submission in June of that year.Par Pharmaceutical commenced the first of two phase III clinical trials of megestrol acetate oral suspension (PAR 100.2) in cancer-induced anorexia in the first quarter of 2006. However, this trial was discontinued in September 2006 because of slow patient enrolment. The company intends to discuss future development options in this indication with the FDA.New formulations or dosage forms of megestrol acetate concentrated suspension are also in

  4. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  5. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric bindin...

  6. Par j 1 and Par j 2, the major allergens from Parietaria judaica pollen, have similar immunoglobulin E epitopes.

    Science.gov (United States)

    Asturias, J A; Gómez-Bayón, N; Eseverri, J L; Martínez, A

    2003-04-01

    Parietaria judaica is the main cause of allergy in Mediterranean countries. The major allergens from P. judaica pollen, Par j 1 and Par j 2, have amino acid sequence identity of 45% and contain eight cysteine residues involved in disulphide bonds that compact the structure. The aim of the study was to identify IgE-binding epitopes on Par j 1 and Par j 2, the major allergens from P. judaica pollen and correlate them with the three-dimensional structure of the proteins. Overlapping peptides representing the complete length of Par j 1 and Par j 2 were synthesized on a cellulose-derivatized membrane. Sera from 17 P. judaica-allergenic patients were used to identify IgE-binding epitopes. Homology modelling of the three dimensional structure of both allergens was generated using the Swiss-Model software on the basis of previously reported crystal structures. Five and eight IgE-binding epitopes were identified on Par j 1 and Par j 2 allergens, respectively. Both proteins belonged to the non-specific lipid transfer proteins (ns-LTP) family and therefore a three-dimensional model of both allergens was constructed on the basis of the maize ns-LTP crystal structure. Par j 1 and Par j 2 allergens have three similar allergenic epitopes with high homology and identical conformation. Three similar IgE-epitopes of major allergens from P. judaica have been described. They could be good candidates for designing of IgE haptens as therapeutic agents with reduced anaphylactic side-effects or for developing hypoallergenic variants of these major allergens.

  7. Scleral Buckling for Rhegmatogenous Retinal Detachment Associated with Pars Planitis.

    Science.gov (United States)

    Kim, Yong-Kyu; Yoon, Wontae; Ahn, Jae Kyoun; Park, Sung Pyo

    2016-01-01

    Purpose. To evaluate the surgical outcome of scleral buckling (SB) in rhegmatogenous retinal detachment (RRD) patients associated with pars planitis. Methods. Retrospective review of RRD patients (32 eyes of pars planitis RRD and 180 eyes of primary RRD) who underwent SB. We compared primary and final anatomical success rates and visual outcomes between two groups. Results. Primary and final anatomical success were achieved in 25 (78.1%) and 31 (96.8%) eyes in the pars planitis RRD group and in 167 eyes (92.7%) and 176 eyes (97.7%) in primary RRD group, respectively. Both groups showed significant visual improvement (p Pars planitis RRD group was associated with higher rate of postoperative proliferative vitreoretinopathy (PVR) development (12.5% versus 2.8%, p = 0.031). Pars planitis and high myopia were significant preoperative risk factors and pseudophakia was borderline risk for primary anatomical failure after adjusting for various clinical factors. Conclusions. Pars planitis associated RRD showed inferior primary anatomical outcome after SB due to postoperative PVR development. However, final anatomical and visual outcomes were favorable. RRD cases associated with pars planitis, high myopia, and pseudophakia might benefit from different surgical approaches, such as combined vitrectomy and SB.

  8. Scleral Buckling for Rhegmatogenous Retinal Detachment Associated with Pars Planitis

    Directory of Open Access Journals (Sweden)

    Yong-Kyu Kim

    2016-01-01

    Full Text Available Purpose. To evaluate the surgical outcome of scleral buckling (SB in rhegmatogenous retinal detachment (RRD patients associated with pars planitis. Methods. Retrospective review of RRD patients (32 eyes of pars planitis RRD and 180 eyes of primary RRD who underwent SB. We compared primary and final anatomical success rates and visual outcomes between two groups. Results. Primary and final anatomical success were achieved in 25 (78.1% and 31 (96.8% eyes in the pars planitis RRD group and in 167 eyes (92.7% and 176 eyes (97.7% in primary RRD group, respectively. Both groups showed significant visual improvement (p<0.001 and there were no significant differences in final visual acuity. Pars planitis RRD group was associated with higher rate of postoperative proliferative vitreoretinopathy (PVR development (12.5% versus 2.8%, p=0.031. Pars planitis and high myopia were significant preoperative risk factors and pseudophakia was borderline risk for primary anatomical failure after adjusting for various clinical factors. Conclusions. Pars planitis associated RRD showed inferior primary anatomical outcome after SB due to postoperative PVR development. However, final anatomical and visual outcomes were favorable. RRD cases associated with pars planitis, high myopia, and pseudophakia might benefit from different surgical approaches, such as combined vitrectomy and SB.

  9. Multi-scale photoacoustic remote sensing (PARS) (Conference Presentation)

    Science.gov (United States)

    Haji Reza, Parsin; Bell, Kevan; Shi, W.; Zemp, Roger J.

    2016-03-01

    We introduce a novel multi-scale photoacoustic remote sensing (PARS) imaging system. Our system can provide optical resolution details for superficial structures as well as acoustic resolution for deep-tissue imaging down to 5 cm, in a non-contact setting. PARS system does not require any contact with the sample or ultrasound coupling medium. The optical resolution PARS (OR-OARS) system uses optically focused pulsed excitation with optical detection of photoacoustic signatures using a long-coherence interrogation beam co-focused and co-scanned with the excitation spot. In the OR-PARS initial pressures are sampled right at their subsurface origin where acoustic pressures are largest. The Acoustic resolution PARS (AR-PARS) picks up the surface oscillation of the tissue caused by generated photoacoustic signal using a modified version of Michelson interferometry. By taking advantage of 4-meters polarization maintaining single-mode fiber and a green fiber laser we have generated a multi-wavelength source using stimulated Raman scattering. Remote functional imaging using this multi-wavelength excitation source and PARS detection mechanism has been demonstrated. The oxygen saturation estimations are shown for both phantom and in vivo studies. Images of blood vessel structures for an In vivo chicken embryo model is demonstrated. The Phantom studies indicates ~3µm and ~300µm lateral resolution for OR-PARS and AR-PARS respectively. To the best of our knowledge this is the first dual modality non-contact optical and acoustic resolution system used for in vivo imaging.

  10. Quantitation of the major allergen of several Parietaria pollens by an anti-Par 1 monoclonal antibody-based ELISA. Analysis of crossreactivity among purified Par j 1, Par o 1 and Par m 1 allergens.

    Science.gov (United States)

    Ayuso, R; Carreira, J; Polo, F

    1995-10-01

    Plants of the genus Parietaria, Urticaceae family, represent a major cause of pollinosis in the Mediterranean area. Different Parietaria species crossreact to a great extent, but studies on the crossreactivity among the major allergens of these pollens have not been carried out so far. To develop an immunochemical method to quantify the major Parietaria judaica allergen, Par j 1, as well as to verify the presence of Par j 1-like proteins in different Urticaceae pollens. These proteins would be purified in order to study the cross-reactivity among them. Immunoaffinity chromatography with a monoclonal antibody, solid-phase enzyme-linked immunoassays and SDS-PAGE. A monoclonal antibody-based ELISA for the quantification of Par j 1 has been developed. The assay has a sensitivity of 0.2 ng/mL and shows a high correlation with the allergenic activity of P. judaica extracts determined by radioallergosorbent assay (RAST) inhibition. By means of this assay, proteins homologous to Par j 1 were detected in P. officinalis and P. mauritanica. These proteins (Par o 1 and Par m 1, respectively) were purified by affinity chromatography using the same monoclonal antibody employed in the ELISA. Crossed-inhibition experiments demonstrated that Par j 1, Par o 1, and Par m 1, competed for the binding of specific IgE from a P. judaica-sensitive patients serum pool. The results here described suggest that shared allergenic epitopes are present in the three main allergens investigated, which may simplify the diagnosis and therapy for Parietaria allergy.

  11. uPAR as anti-cancer target

    DEFF Research Database (Denmark)

    Lund, Ida K; Illemann, Martin; Thurison, Tine

    2011-01-01

    , and a potential diagnostic and predictive impact of the different uPAR forms has been reported. Hence, pericellular proteolysis seems to be a suitable target for anti-cancer therapy and numerous approaches have been pursued. Targeting of this process may be achieved by preventing the binding of uPA to u...... using mouse monoclonal antibodies (mAbs) against mouse uPA or uPAR. These reagents will target uPA and uPAR in both stromal cells and cancer cells, and their therapeutic potential can now be assessed in syngenic mouse cancer models....

  12. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is released in response to inflammatory stimuli, and plasma levels are associated with long-term outcomes. The ischemia/reperfusion injury caused by cardiac arrest (CA) and resuscitation triggers an inflammatory response...... analysis shoved an AUC of 0.76 at 6 hours. In the subgroup of CA of cardiac cause, the AUC was 0.84. CONCLUSION: suPAR levels at 6 and 36 hours after CA were significantly higher in nonsurviving patients compared with survivors; however, the overlap in suPAR levels between the outcome groups...

  13. Par j 1 and Par j 2, the two major allergens in Parietaria judaica, bind preferentially to monoacylated negative lipids.

    Science.gov (United States)

    González-Rioja, Roberto; Asturias, Juan A; Martínez, Alberto; Goñi, Félix M; Viguera, Ana Rosa

    2009-03-01

    Par j 1 and Par j 2 proteins are the two major allergens in Parietaria judaica pollen, one of the main causes of allergic diseases in the Mediterranean area. Each of them contains eight cysteine residues organized in a pattern identical to that found in plant nonspecific lipid transfer proteins. The 139- and 102-residue recombinant allergens, corresponding respectively to Par j 1 and Par j 2, refold properly to fully functional forms, whose immunological properties resemble those of the molecules purified from the natural source. Molecular modeling shows that, despite the lack of extensive primary structure homology with nonspecific lipid transfer proteins, both allergens contain a hydrophobic cavity suited to accommodate a lipid ligand. In the present study, we present novel evidence for the formation of complexes of these natural and recombinant proteins from Parietaria pollen with lipidic molecules. The dissociation constant of oleyl-lyso-phosphatidylcholine is 9.1 +/- 1.2 microm for recombinant Par j 1, whereas pyrenedodecanoic acid shows a much higher affinity, with a dissociation constant of approximately 1 microm for both recombinant proteins, as well as for the natural mixture. Lipid binding does not alter the secondary structure content of the protein but is very efficient in protecting disulfide bonds from reduction by dithiothreitol. We show that Par j 1 and Par j 2 not only bind lipids from micellar dispersions, but also are able to extract and transfer negative phospholipids from bilayers.

  14. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  15. La modelisation mathematique dans l'enseignement de la chimie des gaz a des eleves de la cinquieme annee du secondaire

    Science.gov (United States)

    Gauthier, Diane

    Les problemes d'enseignement de la chimie des gaz parfaits sont donc importants. Si plusieurs etudes ont ete realisees dans le but d'identifier et d'interpreter ces problemes, aucune recherche, a notre connaissance, n'a ete realisee sur l'enseignement des lois sur les gaz parfaits. Notre recherche sur l'enseignement est donc pionniere. Elle a pour objectif general de construire et d'analyser une sequence d'enseignement de la chimie des gaz comportant diverses situations de modelisation mathematique des conduites des gaz. Les principaux objectifs specifiques sont les suivants: (1) identifier et caracteriser les situations qui provoquent une evolution des conceptions naives des eleves, evolution vers des connaissances plus adequate sur les gaz; (2) identifier et caractEriser les situations qui provoquent une evolution des connaissances mathematiques des eleves leur permettant d'interpreter convenablement les resultats des experiences, d'eprouver leurs conceptions, de donner un sens aux notions et aux relations impliquees dans les lois des gaz parfaits, lois de Boyle-Mariotte et Gay-Lussac. Une sequence d'enseignement comportant huit situations est d'eleves de secondaire V. La construction de ces situations est orientee par les recherches sur les conceptions naives des eleves, par les etudes sur l'evolution historique des conceptions sur les gaz et des pratiques scientifiques, ainsi que par les etudes theoriques et empiriques realisees en didactique des sciences et des mathematiques. La methodologie de l'ingenierie didactique (Artigue, 1998) qui constitue une application de la theorie des situations didactiques (Brousseau, 1986) est utilisee dans la construction et l'analyse des situations d'enseignement. Une analyse a priori de chacune des situations d'enseignement est effectuee; elle a pour but dexpliquer les choix des taches qui font partie des situations et de preciser la gestion didactique des situations. Diverses situations d'enseignement de la chimie ont ainsi

  16. Bovine pars tuberalis secretions release growth hormone from rat pars distalis of pituitary gland.

    Science.gov (United States)

    Lafarque, Martha María; Ezquer, Marcelo; Aguado, Luis Inocencio; Oliveros, Liliana Beatriz

    2004-08-01

    The pituitary pars tuberalis (PT) is characterized by PT-specific secretory cells which have raised the possibility of an endocrine function for this portion of adenohypophysis. To investigate the effect of the secretion of bovine PT cells into culture medium on growth hormone (GH) response of dispersed pars distalis (PD) cells of rats. 48-hour culture medium of all PT cells at 1 microg of protein concentration induced the greatest GH release from PD cells. After PT cells separation on a discontinuos Percoll gradient and culturing, only the culture medium of cells from 50 and 60% Percoll strength released GH from PD cells. Therefore, cells from 50 and 60% strenght Percoll were cultured together. Only 0.2 mg protein of this culture medium was required to induce the maximal GH release from PD cells, suggesting that these cells could be responsible for producing the factor(s) which affect PD somatotrophe cells. After protein separation by 12% SDS-PAGE of this PT culture medium bands were eluted. The biological activity, measured as ng/ml of GH from PD cells, corresponded to a protein(s) of molecular weight between 45 and 66 kDal. The results indicate that there is an active proteic factor(s) secreted by the PT that acts upon PD cells to stimulate GH release and that PD could be an effector organ for some secretory product(s) of the PT.

  17. Récolte et consommation de pollen par les abeilles

    OpenAIRE

    Odoux, Jean Francois

    2005-01-01

    La récolte de pollen par les abeilles fait appel à des organes spécialisés de l'abeille, comme celle du nectar. Par contre, elle est régie par de très nombreux facteurs, en fonction des ressources, bien sûr, mais aussi des besoins de la colonie, alors que son attractivité n'est pas toujours en rapport avec la qualité. Ce texte décrit le contexte de l'utilisation du pollen par les abeilles, de la récolte à la digestion, d'après une synthèse bibliographique.

  18. PARS: Programs for Analysis and Resizing of Structures, user manual

    Science.gov (United States)

    Haftka, R. T.; Prasad, B.; Tsach, U.

    1979-01-01

    PARS processors and their use, flutter analysis, sensitivity analysis for stresses, and resizing are presented. Design variable definition and interface with finite element model, static constraints and their derivatives, flutter derivatives, and optimization are discussed.

  19. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...

  20. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical...... tumor resection. In the present study, a new uPAR-targeted fluorescent probe was developed and the in vivo applicability was evaluated in a human xenograft mouse model. Most human carcinomas express high level of uPAR in the tumor-stromal interface of invasive lesions and uPAR is therefore considered...... an ideal target for intra-operative imaging. Conjugation of the flourophor indocyanine green (ICG) to the uPAR agonist (AE105) provides an optical imaging ligand with sufficiently high receptor affinity to allow for a specific receptor targeting in vivo. For in vivo testing, human glioblastoma xenograft...

  1. Differences in middle ear ventilation disorders between pars flaccida and pars tensa cholesteatoma in sonotubometry and patterns of tympanic and mastoid pneumatization.

    Science.gov (United States)

    Shinnabe, Akihiro; Hara, Mariko; Hasegawa, Masayo; Matsuzawa, Shingo; Kanazawa, Hiromi; Kanazawa, Takeharu; Yoshida, Naohiro; Iino, Yukiko

    2012-07-01

    To investigate differences in middle ear ventilation mechanisms between pars flaccida and pars tensa cholesteatoma. Retrospective case review. A referral hospital otolaryngology department. Sixty-six ears with pars flaccida cholesteatoma (mean age, 45.7 yr) and 19 ears with pars tensa cholesteatoma (mean age, 58.8 yr) were included. Patients with totally adhesive tympanic membranes or mixed-type cholesteatoma were excluded. Patients underwent canal wall down tympanoplasty with canal reconstruction. The canal wall was reconstructed with tragal or conchal cartilage and cortical bone grafts. Habitual sniffing, preoperative sonotubometry results, mastoid pneumatization (maturation), and postoperative aeration around the stapes were investigated. Preoperative mastoid pneumatization and postoperative aeration around the stapes were measured on computed tomography scans. Ten (15.4%) of 65 patients with pars flaccida cholesteatoma and 3 (15.7%) of 19 patients with pars tensa cholesteatoma were habitual sniffers (p = 0.5). Preoperative sonotubometry indicated that a patulous pattern was more common in ears with pars flaccida than pars tensa cholesteatoma (42.8% versus 7.1%, p pars tensa than pars flaccida cholesteatoma (85.8% versus 42.8%, p pars flaccida than pars tensa cholesteatoma (p pars flaccida and pars tensa cholesteatoma.

  2. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  3. Lumbar vertebral body and pars fractures following laminectomy

    OpenAIRE

    Yadhati, Akshay; Kurra, Swamy; Tallarico, Richard A.; Lavelle, William F.

    2017-01-01

    Abstract A 56-year-old alcoholic male incurred L5 vertebral body and bilateral L4 pars fractures with progressive L4 on L5 anterolisthesis following low-energy falls while intoxicated. Recently, he had a L3?S1 laminectomy for lumbar spinal stenosis with claudication. Preoperative imaging and radiographs were negative for pars defects and instability, so an isolated decompressive surgery was performed. Following low-energy falls, his outpatient work-up revealed fractures through the bilateral ...

  4. Study of contamination by 100 {mu}Ci of Sr 90 in the rat: clinical, hematological and osseous effects (appearance of osteosarcomas); Etude d'une contamination par 100 {mu}Ci de Sr 90 chez le rat: consequences cliniques, hematologiques et osseuses (apparition d'osteosarcomes)

    Energy Technology Data Exchange (ETDEWEB)

    Graf, B.; Lafuma, J.; Parmentier, C.; Parmentier, N. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-07-01

    Clinical, hematological and osseous effects following an intramuscular injection of 100 {mu}Ci 90 Sr were studied in the rat. In spite of the magnitude of the injection and the resulting damage, the elimination of strontium could compare with what occurs after an injection at tracer doses. Comparing with the controls at the outcoming time, clinical monitoring mainly brought out a loss of body weight. Fairly early (20. - 30. day) there occurred severe hematological damage, especially on lymphocyte line, which subsided spontaneously. As foreseen, the anatomo-pathological survey of the early period showed bone and medullar lesions in the areas of enchondral ossification. In the late period, bone sarcomas occurred in nine animals out of ten. The outstanding histological type was osteogenic osteosarcomas; besides, two animals experienced bilateral tumors. (authors) [French] Les auteurs etudient les consequences cliniques, hematologiques et osseuses d'une contamination par 100 microcuries de Sr 90 injectes par voie intramusculaire chez le rat. Malgre l'importance de la contamination et les lesions consequentes, l'elimination du Sr 90 est comparable a celle que l'on observe apres injection de doses traceuses. La surveillance clinique ne met essentiellement en evidence, a la periode terminale, qu'une diminution du poids par rapport aux temoins. Les lesions hematologiques sont importantes, predominant sur la lignee lymphocytaire. Elles sont relativement precoces (20e - 30e jours) et regressent spontanement. La surveillance anatomo-pathologique de la periode precoce a montre, comme il etait previsible, des lesions osseuses et medullaires dans les zones d'ossification enchondrale. A la periode tardive, la survenue de sarcomes osseux a ete observee chez neuf animaux sur dix. Le type histologique predominant est l'osteosarcome osteogenique et il faut signaler egalement les tumeurs bilaterales observees chez deux animaux. (auteurs)

  5. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  6. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids

    Science.gov (United States)

    Pillet, Flavien; Passot, Fanny Marie

    2017-01-01

    Bacterial centromeres–also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA—the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi) mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres. PMID:28562673

  7. Developpement d'une methode de Monte Carlo dependante du temps et application au reacteur de type CANDU-6

    Science.gov (United States)

    Mahjoub, Mehdi

    La resolution de l'equation de Boltzmann demeure une etape importante dans la prediction du comportement d'un reacteur nucleaire. Malheureusement, la resolution de cette equation presente toujours un defi pour une geometrie complexe (reacteur) tout comme pour une geometrie simple (cellule). Ainsi, pour predire le comportement d'un reacteur nucleaire,un schema de calcul a deux etapes est necessaire. La premiere etape consiste a obtenir les parametres nucleaires d'une cellule du reacteur apres une etape d'homogeneisation et condensation. La deuxieme etape consiste en un calcul de diffusion pour tout le reacteur en utilisant les resultats de la premiere etape tout en simplifiant la geometrie du reacteur a un ensemble de cellules homogenes le tout entoure de reflecteur. Lors des transitoires (accident), ces deux etapes sont insuffisantes pour pouvoir predire le comportement du reacteur. Comme la resolution de l'equation de Boltzmann dans sa forme dependante du temps presente toujours un defi de taille pour tous types de geometries,un autre schema de calcul est necessaire. Afin de contourner cette difficulte, l'hypothese adiabatique est utilisee. Elle se concretise en un schema de calcul a quatre etapes. La premiere et deuxieme etapes demeurent les memes pour des conditions nominales du reacteur. La troisieme etape se resume a obtenir les nouvelles proprietes nucleaires de la cellule a la suite de la perturbation pour les utiliser, au niveau de la quatrieme etape, dans un nouveau calcul de reacteur et obtenir l'effet de la perturbation sur le reacteur. Ce projet vise a verifier cette hypothese. Ainsi, un nouveau schema de calcul a ete defini. La premiere etape de ce projet a ete de creer un nouveau logiciel capable de resoudre l'equation de Boltzmann dependante du temps par la methode stochastique Monte Carlo dans le but d'obtenir des sections efficaces qui evoluent dans le temps. Ce code a ete utilise pour simuler un accident LOCA dans un reacteur nucleaire de type

  8. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    The breakdown of the barriers formed by extracellular matrix proteins is a pre-requisite for all processes of tissue remodeling. Matrix degradation reactions take part in specific physiological events in the healthy organism but also represent a crucial step in cancer invasion. These degradation...... processes involve a highly organized interplay between proteases and their cellular binding sites as well as specific substrates and internalization receptors. This review article is focused on two components, the urokinase plasminogen activator receptor (uPAR) and the uPAR-associated protein (uPARAP, also...... designated Endo180), that are considered crucially engaged in matrix degradation. uPAR and uPARAP have highly diverse functions, but on certain cell types they interact with each other in a process that is still incompletely understood. uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein...

  9. Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

    Directory of Open Access Journals (Sweden)

    John C Hennessey

    Full Text Available Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET mice. The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals. In our study we aimed to determine the effects of intermediary par2 gene zygosity on vascular tissue responses to PAR2 activation. Specifically, we compared the vasodilator effectiveness of the PAR2 activating peptide 2-furoyl-LIGRLO-amide in aortas of wild-type PAR2 homozygous (PAR2-WT and PAR2-HET mice. In myographs under isometric tension conditions, isolated aortic rings were contracted by alpha 1-adrenoeceptor agonist (phenylephrine, and thromboxane receptor agonist (U46619 and then relaxation responses by the additions of 2-furoyl-LIGRLO-amide, acetylcholine, and nitroprusside were recorded. A Schild regression analysis of the inhibition by a PAR2 antagonist (GB-83 of PAR2 agonist-induced aortic ring relaxations was used to compare receptor expression in PAR2-WT to PAR2-HET. PAR2 mRNA in aortas was measured by quantitative real-time PCR. In aortas contracted by either phenylephrine or U46619, the maximum relaxations induced by 2-furoyl-LIGRLO-amide were less in PAR2-HET than in the gender-matched PAR2-WT. GB-83 was 3- to 4-fold more potent for inhibition of 2fly in PAR2-HET than in PAR2-WT. PAR2 mRNA content of aortas from PAR2-HET was not significantly different than in PAR2-WT. Acetylcholine- and nitroprusside-induced relaxations of aortas from PAR2-HET were not significantly different than in PAR2-WT and PAR2 knockout. An interesting secondary finding was that relaxations induced by agonists of PAR2 and muscarinic receptors were larger in females than in males. We conclude that the lower PAR2-mediated responses in PAR2-HET aortas are consistent with evidence of a lower quantity of functional

  10. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  11. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  12. E. P. R. spectroscopic study of nitroxide mono- and bi-radicals; Etude par spectroscopie de resonance paramagnetique electronique de monoradicaux et de biradicaux nitroxydes

    Energy Technology Data Exchange (ETDEWEB)

    Lemaire, H. [Commissariat a l' Energie Atomique, Grenoble, 38 (France). Centre d' Etudes Nucleaires

    1967-07-01

    experimentales d'etude de produits parfaitement bien definis au point de vue structure chimique. L'etude par resonance paramagnetique electronique de monoradicaux nitroxydes conduit a la determination des axes et des elements du tenseur d'interaction hyperfine electron-noyau d'azote et du tenseur d'anisotropie du facteur de Lande: les resultats sont relies a la structure electronique des radicaux. On interprete qualitativement l'influence du solvant sur les elements des tenseurs, ainsi que les elargissements selectifs des raies hyperfines en milieu visqueux. Dans les biradicaux nitroxydes, la structure hyperfine depend non seulement des interactions magnetiques propres a chaque monomere, mais egalement de la grandeur de l'interaction d'echange separant les etats singulet et triplet du dimere; les biradicaux etudies ici sont les premiers composes organiques pour lesquels l'influence de l'echange sur la structure hyperfine est clairement mise en evidence. La presence de deux electrons non apparies introduit egalement une interaction magnetique dipolaire electron-electron, que l'on peut mettre a profit, dans le cas d'un echange intermediaire, pour determiner le signe de l'echange en etudiant le biradical dans un cristal liquide. Ces composes presentent egalement des elargissements selectifs de transitions hyperfines lorsque la viscosite du solvant croit. La theorie utilisee pour interpreter les largeurs de raie des monoradicaux est etendue au cas des biradicaux; elle rend compte des resultats experimentaux si l'on introduit simultanement les anisotropies des facteurs de Lande et des interactions dipolaires electrons-noyaux et electron-electron, en conduisant a une autre determination du signe de l'echange. (auteur)

  13. Combined pars plana vitrectomy-scleral buckle versus pars plana vitrectomy for proliferative vitreoretinopathy.

    Science.gov (United States)

    Lai, Frank H P; Lo, Ernie C F; Chan, Vesta C K; Brelen, Mårten; Lo, Wai Ling; Young, Alvin L

    2016-04-01

    The purpose of the study is to evaluate the surgical outcomes of combined pars plana vitrectomy-scleral buckle (PPV-SB) versus pars plana vitrectomy (PPV) for rhegmatogenous retinal detachment complicated with proliferative vitreoretinopathy (PVR). One thousand one hundred and seventy four patients with rhegmatogenous retinal detachment surgery between January 2002 and December 2013 were retrospectively reviewed. Patients with grade C PVR treated with either combined PPV-SB or PPV alone were included in the study. Study outcomes included single surgery anatomic success rate and postoperative visual outcome at 12 months postoperatively. Seventy-seven patients with grade C PVR were identified for analysis. At the end of 12-month follow-up, 80.5 % eyes (33/41) in the PPV-SB group and 58.3 % eyes (21/36) in the PPV group achieved single surgery anatomical success. In a multiple logistic regression model, none of the baseline variables (age, gender, macula status, grade of PVR, extent of detachment, presence of vitreous hemorrhage, lens status, status of high myopia) nor types of retinal detachment surgery (use of scleral buckle, barrier endolaser, 360 degree endolaser, cryopexy, retinectomy, tamponade agent, phacoemulsification) had significant effect on single surgery anatomical success. The post-treatment mean logMAR visual acuity of the PPV-SB group was 1.58 ± 0.58 and the PPV group was 1.57 ± 0.61. There was no significant difference in the postoperative visual acuity between the two groups (P = 0.849). For patients with grade C PVR, PPV-SB did not demonstrate a superiority over PPV alone in achieving single surgery anatomical success.

  14. Pars planitis: Epidemiology, clinical characteristics, management and visual prognosis

    Directory of Open Access Journals (Sweden)

    Pinar Cakar Ozdal

    2015-01-01

    Full Text Available Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease.

  15. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    Energy Technology Data Exchange (ETDEWEB)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned.

  16. Pars Planitis: Epidemiology, Clinical Characteristics, Management and Visual Prognosis.

    Science.gov (United States)

    Ozdal, Pinar Cakar; Berker, Nilufer; Tugal-Tutkun, Ilknur

    2015-01-01

    Pars planitis is an idiopathic chronic intermediate uveitis which predominantly affects children and adolescents, and accounts for 5-26.7% of pediatric uveitis. Although an autoimmune process with a genetic predisposition has been suggested, its etiology still remains unknown. The most common presenting symptoms are floaters and blurred vision. Diffuse vitreous cells, haze, snowballs and snowbanks are typical findings of pars planitis. Peripheral retinal vasculitis, optic disc edema and anterior segment inflammation are other well-known findings. Although pars planitis is known to be a benign form of uveitis in most cases, it may become a potentially blinding disease due to complications including cataract, cystoid macular edema, vitreous opacities and optic disc edema. Cystoid macular edema is the most common cause of visual morbidity. Band keratopathy, epiretinal membrane formation, vitreous condensation, neovascularizations, vitreous hemorrhage, retinal detachment, cyclitic membranes, glaucoma and amblyopia may develop as a consequence of the chronic course of the disease. Exclusion of infectious and non-infectious causes which may present with intermediate uveitis is of utmost importance before starting treatment. Treatment of pars planitis has been a controversial issue. There is no consensus specifically for treatment of cases with minimal inflammation and relatively good visual acuity. However, current experience shows that pars planitis may cause severe inflammation and needs an aggressive treatment. A stepladder approach including corticosteroids, immunosupressive agents, anti-tumor necrosis factor-alpha and pars plana vitrectomy and/or laser photocoagulation is the most commonly used method for treatment of pars planitis. Adequate control of inflammation and prompt detection of associated complications are crucial in order to improve the overall prognosis of the disease.

  17. PH motifs in PAR1&2 endow breast cancer growth

    OpenAIRE

    Kancharla, A.; Maoz, M.; Jaber, M.; Agranovich, D.; Peretz, T.; Grisaru-Granovsky, S.; Uziely, B.; Bar-Shavit, R.

    2015-01-01

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind wi...

  18. La ganadería lechera en la cuenca alta de Cañete: su rol en el desarrollo de los sistemas agrarios y su articulación al mercado nacional

    Directory of Open Access Journals (Sweden)

    1986-01-01

    Full Text Available La question laitière est un des principaux thèmes de discussion de la réforme du système agro-alimentaire péruvien. Au delà des choix entre importer en profitant des cours mondiaux ou favoriser la production nationale, se pose le problème du modèle de développement à suivre. Faut-il concentrer les efforts sur les bassins spécialisés (Arequipa et Cajamarca en particulier ou doit-on promouvoir le développement des petites unités disséminées dans les microbassins de la zone andine? En choisissant d'analyser les conditions de la production de lait paysanne et de sa transformation en fromage, l'article pose des jalons en faveur de la deuxième voie. Par ailleurs, en abordant la question des rapports au marché de la petite production fromagère, il met en évidence les facteurs déterminants de l'essor et de la régression de ce produit paysan dans un contexte d'internationalisation des marchés laitiers. La problemática lechera es uno de los principales temas del debate de la reforma del sistema agro-alimentario peruano. Más allá de las opciones de importación aprovechando los bajos precios internacionales o de promoción de la producción nacional, se plantea el problema del modelo de desarrollo a seguir. ¿Se tiene que concentrar los esfuerzos en las cuencas ya especializadas (Arequipa y Cajamarca en particular o se debe promover el desarrollo de las pequeñas unidades familiares diseminadas en las microcuencas de la zona andina? Escogiendo analizar las condiciones de la producción lechera campesina y de su transformación en queso serrano, el artículo avanza pautas de investigación en favor de la segunda vía. Además, abordando el tema de la inserción de la pequeña producción quesera al mercado, pone en evidencia los factores determinantes de la expansión y regresión de este producto campesino en un contexto de internacionalización de los mercados de los productos lecheros. One of the main discussion points of the

  19. Par Pond vegetation status Summer 1995 -- October survey descriptive summary

    Energy Technology Data Exchange (ETDEWEB)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-11-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this late October survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maiden cane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned.

  20. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    , in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. MATERIALS AND METHODS: Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal...... nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. RESULTS: At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than...... in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  1. CFD Application to Hydrogen Risk Analysis and PAR Qualification

    Directory of Open Access Journals (Sweden)

    Jinbiao Xiong

    2009-01-01

    Full Text Available A three dimensional computation fluid dynamics (CFD code, GASFLOW, is applied to analyze the hydrogen risk for Qinshan-II nuclear power plant (NPP. In this paper, the effect of spray modes on hydrogen risk in the containment during a large break loss of coolant accident (LBLOCA is analyzed by selecting three different spray strategies, that is, without spray, with direct spray and with both direct and recirculation spray. A strong effect of spray modes on hydrogen distribution is observed. However, the efficiency of the passive auto-catalytic recombiners (PAR is not substantially affected by spray modes. The hydrogen risk is significantly increased by the direct spray, while the recirculation spray has minor effect on it. In order to simulate more precisely the processes involved in the PAR operation, a new PAR model is developed using CFD approach. The validation shows that the results obtained by the model agree well with the experimental results.

  2. PARS PLANA VITRECTOMY THROUGH A CUSTOM FLEXIBLE IRIS PROSTHESIS.

    Science.gov (United States)

    Toygar, Okan; Snyder, Michael E; Riemann, Christopher D

    2016-08-01

    To demonstrate the outcomes of pars plana vitrectomy in patients with custom flexible iris prosthesis (CFIP). The medical records of patients who underwent CFIP placement were retrospectively reviewed. Patients who underwent pars plana vitrectomy concurrent with or after placement of CFIP were identified. Preoperative, intraoperative, and postoperative parameters were analyzed. Surgeons were surveyed regarding the technical aspects of the vitreoretinal surgery. Outcome measures included: anatomic success, complications, surgeon-rated ease of visualization through CFIP during pars plana vitrectomy, and Snellen best-corrected visual acuity. Twenty-four surgeries were performed in 20 eyes of 20 patients. Postoperative best-corrected visual acuity improved in 11 eyes (55%), remained unchanged in 5 eyes (25%), and declined in 4 eyes (20%) after a mean follow-up of 16.1 ± 16.\

  3. Protease activated receptor-2 (PAR2): possible target of phytochemicals.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-09-01

    The use of phytochemicals either singly or in combination with other anticancer drugs comes with an advantage of less toxicity and minimal side effects. Signaling pathways play central role in cell cycle, cell growth, metabolism, etc. Thus, the identification of phytochemicals with promising antagonistic effect on the receptor/s playing key role in single transduction may have better therapeutic application. With this background, phytochemicals were screened against protease-activated receptor 2 (PAR2). PAR2 belongs to the superfamily of GPCRs and is an important target for breast cancer. Using in silico methods, this study was able to identify the phytochemicals with promising binding affinity suggesting their therapeutic potential in the treatment of breast cancer. The findings from this study acquires importance as the information on the possible agonists and antagonists of PAR2 is limited due its unique mechanism of activation.

  4. La projection par plasma : une revue

    Science.gov (United States)

    Fauchais, P.; Grimaud, A.; Vardelle, A.; Vardelle, M.

    are presented in the fields of aeronautics and mechanics. La qualité d'un dépôt projete par plasma dépend de nombreux paramètres que l'on commence à mieux appréhender du fait des progrès de la modélisation et de la métrologie tant des écoulements plasmas que des transferts plasma-particules ou que des conditions d'écrasement et de refroidissement des particules lors de leur impact sur le substrat ou les couches déjà déposées. Les techniques de mesure utilisdes et leurs limitations sont d'abord rappelées tant pour les jets de plasma que pour les particules en vol et l'importance des différents phénomènes intervenant dans les transferts plasma-particules est soulignée : gradients de température et de concentration d'espèces chimiques très élevés autour des particules, effets de propagation de la chaleur, notamment pour les particules céramiques, effet d'évaporation, effet de raréfaction sensible dès la pression atmosphérique. Les problèmes de distribution de taille et de vitesse d'injection des particules sont également abordés car ils conditionnent les distributions de trajectoires et donc le traitement des particules dans le jet de plasma. La génération du plasma montre d'une part 1'influence considérable de l'injection du gaz, de sa nature, du dessin de la chambre d'arc et de la tuyère ainsi que du pompage de l'air ambiant sur la longueur des jets de plasma d'arc et d'autre part les problèmes d'injection pour éviter le couplage avec la décharge dans les jets de plasmas R.E Tout ceci est illustré avec des exemples de dépôt d'alumine, de zircone, de cermet carbure et de nickel. L'écrasement des particules est ensuite abordé avec les problèmes de réactions chimiques, de trempe ultra-rapide et donc de structure cristalline des dépôts, d'adhdsion mais aussi de containtes résiduelles et de leur contrôle via les gradients de température dans les dépôts pendant le tir. Enfin quelques applications actuelles sont pr

  5. Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets.

    Science.gov (United States)

    Duvernay, Matthew T; Temple, Kayla J; Maeng, Jae G; Blobaum, Anna L; Stauffer, Shaun R; Lindsley, Craig W; Hamm, Heidi E

    2017-01-01

    Human platelets display a unique dual receptor system for responding to its primary endogenous activator, α-thrombin. Because of the lack of efficacious antagonists, the field has relied on synthetic peptides and pepducins to describe protease-activated receptor PAR1 and PAR4 signaling. The precise contributions of each receptor have not been established in the context of thrombin. We took advantage of newly discovered PAR antagonists to contrast the contribution of PAR1 and PAR4 to thrombin-mediated activation of the platelet fibrin receptor (GPIIbIIIa). PAR1 is required for platelet activation at low but not high concentrations of thrombin, and maximal platelet activation at high concentrations of thrombin requires PAR4. As the concentration of thrombin is increased, PAR1 signaling is quickly overcome by PAR4 signaling, leaving a narrow window of low thrombin concentrations that exclusively engage PAR1. PAR4 antagonism reduces the maximum thrombin response by over 50%. Thus, although the PAR1 response still active at higher concentrations of thrombin, this response is superseded by PAR4. Truncation of a known PAR4 antagonist and identification of the minimum pharmacophore converted the mechanism of inhibition from noncompetitive to competitive, such that the antagonist could be outcompeted by increasing doses of the ligand. Fragments retained efficacy against both soluble and tethered ligands with lower cLogP values and an increased free fraction in plasma. These reversible, competitive compounds represent a route toward potentially safer PAR4 antagonists for clinical utility and the development of tools such as radioligands and positron emission tomography tracers that are not currently available to the field for this target. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  6. La parálisis cerebral en el cine

    OpenAIRE

    María Lucila MERINO MARCOS

    2005-01-01

    [ES] En los últimos veinticinco años se han rodado un número importante de películas en las que el protagonista o algún personaje secundario presentaban o simulaban una parálisis cerebral. Estos personajes en ocasiones han sido interpretados por personas con minusvalías. En la narración de su historia las cintas han incluido diversos aspectos sanitario-asistenciales, sociales y familiares obligados en el campo de la parálisis cerebral. [EN] In the last twenty-five years, a number of import...

  7. Transplantaciones tendinosas por parálisis radial

    OpenAIRE

    De la Puente, Luis; Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Perú

    2014-01-01

    Entre las parálisis periféricas determinadas por lesiones traumáticas de los nervios, la parálisis del radial es la que origina mayores perturbaciones en las funciones del miembro. La inhabilitación del miembro enfermo es, generalmente, mas seria que la que ocasionan las lesiones del nervio cubital o del mediano, nervios que, funcionalmente, son susceptibles de suplirse en el territorio muscular que inervan conjuntamente. Among peripheral paralysis determined by traumatic nerve injuries, p...

  8. Predicting Spectral and PAR Light Attenuation in Greenlandic Coastal Waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Stedmon, Colin A.; Markager, Stiig

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  9. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  10. Intoxication par la paraphényléne-diamine

    African Journals Online (AJOL)

    raoul

    9 mars 2011 ... La symptomatologie des intoxications aigues par la PPD est stéréotypée, le tableau clinique était dominé au départ par un oedème cervico-facial avec une ... réalisée chez 13% des patients devant une hyperkaliémie (8,6%) et/ou effondrement de la diurèse (5%), en moyenne 2 séances avec des extrêmes ...

  11. Intact and cleaved uPAR forms: diagnostic and prognostic value in cancer

    DEFF Research Database (Denmark)

    Rasch, M.G.; Lund, I.K.; Hoyer-Hansen, G.

    2008-01-01

    PA-catalyzed cleavage of uPAR is fast on the cell surface, when uPA is bound to a neighboring uPAR molecule. uPAR can be shed from the cell surface. However, the soluble form cannot be cleaved by uPA. Glycolipid-anchored and soluble forms of intact, uPAR(I-III), and cleaved receptor, uPAR(II-III) and uPAR(I), have been...... identified in tissue and body fluids. It is well-established, that the total amount of all uPAR forms is a strong prognostic marker in different types of cancer. Using immunoassays, measuring the individual uPAR forms, has revealed that the cleaved uPAR forms are even stronger prognostic markers and have...

  12. Adjustment of a direct method for the determination of man body burden in Pu-239 on by X-ray detection of U-235; Mise au point d'une methode directe de determination de la charge corporelle en plutonium 239 chez l'homme par detection X de l'uranium 235

    Energy Technology Data Exchange (ETDEWEB)

    Boulay, P. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-04-01

    The use of Pu-239 on a larger scale sets a problem about the contamination measurement by aerosol at lung level. A method of direct measurement of Pu-239 lung burden is possible, thanks to the use of a large area window proportional counter. A counter of such pattern, has been especially carried out for this purpose. The adjustment of the apparatus allows an adequate sensibility to detect a contamination at the maximum permissible body burden level. Besides, a method for individual 'internal calibration', with a plutonium mock: the protactinium-233, is reported. (author) [French] L'utilisation a une echelle de plus en plus large du plutonium-239 pose un probleme de la mesure de la contamination par aerosol au niveau du poumon. Une methode de mesure directe de la charge pulmonaire en plutonium-239 est possible grace a l'utilisation d'un compteur proportionnel a fenetre de grande surface. Un compteur de ce type a specialement ete realise dans ce but. La mise au point de l'appareillage permet une sensibilite suffisante pour deceler une contamination au niveau de la Q.M.A (quantite maximale admissible). D'autre part, une methode 'd'etalonnage interne' de l'individu a l'aide d'un simulateur de plutonium, le protactinium-233, est decrite. (auteur)

  13. A study of the fluorescence of the rare gases excited by nuclear particles. Use of the principle for the detection of nuclear radiation by scintillation; Etude de la fluorescence des gaz rares excites par des particules nucleaires. Utilisation pour la detection des rayonnements nucleaires par scintillation

    Energy Technology Data Exchange (ETDEWEB)

    Koch, L. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1959-12-15

    In the first part is studied the properties of atoms excited by the passage of {alpha} particles through the various rare gases at atmospheric pressure. A spectral analysis of the emitted light showed that certain impurities play an important part in producing the fluorescence, and it has led to the conclusion that the light emission contains at least two components - one very short - lived due to the direct deexcitation of the rare gas, the other relatively slower due to the energy transfers to the impurity. The measurement of the life-time of the excited states has confirmed this foregoing hypothesis, the rapid part of the impulse is extremely short: less than 2,25.10{sup -9} s in the case of xenon; the slower part has a life-time depending directly on the nitrogen concentration, nitrogen being the impurity giving the largest effect in all cases. The study of rare gases under the influence of an electric field has made it possible to show that the amount of light produced by an {alpha} particle can be multiplied (by 60, for example, in a field of 600 V:cm) so that the luminescent efficiency is greater than in the case of INaTI. In the second part the characteristics of the rare gases acting as scintillators is examined, the most important property being the absence of fluorescence saturation when the intensity of the excitation incident on the gas is very large. This, together with the very short time of scintillation has made it possible to study a certain number of nuclear physical applications (heavy particle energy-measurements, kinetic studies on nuclear reactors, neutron spectroscopy). (author) [French] On etudie dans la premiere partie les proprietes des atomes excites par le passage de particules {alpha} dans les differents gaz rares a la pression atmospherique. L'etude spectrale de la lumiere emise a montre que certaines impuretes jouent un role considerable dans la fluorescence et on a ete amene a penser que l'emission de lumiere comporte au

  14. [A middle to long-term clinical study on pars flaccida and pars tensa cholesteatoma using survival analysis].

    Science.gov (United States)

    Somekawa, Yukihiro; Nagashima, Tsutomu; Masaki, Tomoyuki; Asano, Katsuji; Yajima, Ryoto; Himi, Tetsuo

    2014-12-01

    The current clinical study was performed on 311 cases of pars flaccida and 89 cases of pars tensa cholesteatoma which were treated with canal wall reconstructed tympanoplasty between 1991 and 2012. The average follow-up time of these patients was 5.3 years. Since follow-up periods were different in each case and some censored patients were involved, we used survival analysis on this study to discuss the cumulative rates of disease-free successful cases and the rates of recurrent cholesteatoma throughout the postoperative course. The disease-free successful cases were defined as those cases in which patients were both out of re-operation with recurrent and residual cholesteatoma and out of revision operation with another problem, furthermore, maintained good hearing outcome. Based on the criteria set by the Japan Otological Society (2010), the cases that satisfied the following were evaluated as good hearing results; (a) a successful case in which preoperative bone conduction was used, and (b) a case in which the postoperative air-bone gap was within 20dB after tympanoplasty for chronic otitis media. The analysis results were shown for each of (a) and (b). 1. In pars flaccida cholesteatoma, the 5-year survival rate of successful case was (a) 76.1% and (b) 83.9%, the 10-year survival rate was (a) 58.9% and (b) 73.0%. In pars tensa cholesteatoma, the 5-year survival rate of successful cases was (a) 57.7% and (b) 63.5%, the 10-year rate was (a) 42.1% and (b) 56.9%. A significant difference was seen between pars flaccida and pars tensa cholesteatoma (p pars flaccida cholesteatoma, the 5-year recurrence rate was 7.6% and the 10-year rate was 15.3%, and the recurrence rate increased gradually throughout the follow-up period. On the other hand, in pars tensa cholesteatoma, the increase in the recurrence rate reached a peak 15.8% at 5.5 years after the surgery. A long-term follow-up is necessary when evaluating the clinical results after tympanoplasty.

  15. A sensitive monoclonal antibody-based enzyme-linked immunosorbent assay to quantify Parietaria judaica major allergens, Par j 1 and Par j 2.

    Science.gov (United States)

    Arilla, M C; González-Rioja, R; Ibarrola, I; Mir, A; Monteseirín, J; Conde, J; Martínez, A; Asturias, J A

    2006-01-01

    Parietaria pollen is one of the most important causes of pollinosis in Mediterranean countries. Parietaria judaica pollen extract presents two major allergens, Par j 1 and Par j 2, that belong to the lipid transfer protein family. To develop an ELISA for quantification of both major allergens of P. judaica pollen extracts, and to assert correlation of these allergens content with the allergenic activity of extracts. Natural Par j 1-Par j 2 allergens were purified by gel filtration, ion exchange, and affinity chromatography and identified by mass spectrometry. Rabbit antisera were obtained using this protein preparation as antigen and used for immunoaffinity purification of nPar j 1-Par j 2. BALB/c mice were immunized with the immunopurified nPar j 1-Par j 2 and after fusion and screening by direct ELISA, 5D4 monoclonal antibody was selected as capture antibody to develop a quantitative two-site ELISA. Bound proteins were detected by a biotinylated Par j 1-Par j 2-specific polyclonal antibody. The optimized ELISA was developed from 25 to 8000 pg/mL of purified Par j 1-Par j 2, and a linear portion of 200-1000 pg/mL. The intraassay and interassay coefficients of variation were lower than 7% and 14% respectively. The assay was very sensitive and specific as it had a detection limit of 25 pg/mL and did not detect reactivity with the same family plants, as Urtica. Par j 1-Par j 2 allergens content was measured in 14 P. judaica and two P. officinalis pollen extracts showing a significant correlation with their allergenic activity measured by enzyme allergosorbent test inhibition. The results proved the usefulness of the two-sandwich ELISA for the standardization of Parietaria pollen extracts intended for clinical use, because of its good correlation with allergenic potency.

  16. Study by {alpha}-particle scattering, of the collective states of closed shell nuclei with 28 neutrons, 28 and 50 protons; Etude des etats a caractere collectif des noyaux au voisinage des couches fermees par diffusion inelastique des particules {alpha}

    Energy Technology Data Exchange (ETDEWEB)

    Bruge, G. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-01-01

    This report gives the results from a systematic study by 44 MeV {alpha} particle scattering on the collective states of closed shell nuclei with 28 neutrons, 28 and 50 protons especially in the energy region corresponding to the two phonon vibrational triplet. The nuclei studied are: {sup 46}Ti, {sup 48}Ti, {sup 50}Ti, {sup 52}Cr, {sup 54}Fe, {sup 56}Fe, {sup 58}Fe, {sup 58}Ni, {sup 60}Ni, {sup 62}Ni, {sup 64}Ni, {sup 112}Sn, {sup 114}Sn, {sup 116}Sn, {sup 118}Sn, {sup 120}Sn, {sup 122}Sn and {sup 124}Sn. The theoretical analysis has been made with the Austern and Blair model using a phase shift analysis of the elastic scattering. Deformation lengths {delta}{sub I} = {beta}{sub I}R and transition probabilities obtained are compared with several experimental and theoretical data. (author) [French] Ce rapport donne les resultats d'une etude systematique par diffusion de particules {alpha} de 44 MeV des etats collectifs des noyaux au voisinage des couches fermees a 28 neutrons et 28 et 50 protons, specialement dans la region correspondant au triplet vibrationnel a deux phonons. Les noyaux etudies sont: {sup 46}Ti, {sup 48}Ti, {sup 50}Ti, {sup 52}Cr, {sup 54}Fe, {sup 56}Fe, {sup 58}Fe, {sup 58}Ni, {sup 60}Ni, {sup 62}Ni, {sup 64}Ni, {sup 112}Sn, {sup 114}Sn, {sup 116}Sn, {sup 118}Sn, {sup 120}Sn, {sup 122}Sn et {sup 124}Sn. L'analyse theorique a ete faite a l'aide du modele de Austern et Blair utilisant une analyse en dephasages de la diffusion elastique. Les longueurs de deformation {delta}I = {beta}{sub I}R obtenues pour chaque niveau sont comparees a plusieurs donnees experimentales et theoriques. (auteur)

  17. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  18. Radiative transfer code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    Radiative transfer code: Application to the calculation of PAR. DEVRED EMMANUEL, DUBUISSON .... water vapor from Leckner (1978), with absorption coefficients for these gases taken from Gregg and. Carder (1990). ... law for the size distribution. The particle size ranges from 0.01 "m to 50 "m. 3. Validation of the code.

  19. Indications and Visual Outcome of First Hundred Pars Plana ...

    African Journals Online (AJOL)

    tulyasys

    Indications and Visual Outcome of First. Hundred Pars Plana Vitrectomies at Makkah. Specialist Eye Hospital, Kano, Nigeria. Abdulsalam Shuaib, Abdul Fattah Memon1. Department of Ophthalmology, Bayero University Kano/Aminu Kano Teaching Hospital, Kano State, Nigeria, 1Vitreoretinal Unit,. Al Ibrahim Eye Hospital, ...

  20. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Conclusion: Rhegmatogenous retinal detachment and vitreous hemorrhage are the major indications for pars plana vitrectomy in this environment. As vitreoretinal disorders have become more common in this part of the world, there would be a corresponding increase in demand for vitreoretinal services. There is therefore a ...

  1. Sir Mokshagundam Visvesvaraya–A Visionary Engineer par ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 7; Issue 5. Sir Mokshagundam Visvesvaraya – A Visionary Engineer par Excellence. A V Shankara Rao. Article-in-a-Box Volume 7 Issue 5 May 2002 pp 3-5. Fulltext. Click here to view fulltext PDF. Permanent link:

  2. Efficacite et tolerance du captopril par voie sublinguale dans la ...

    African Journals Online (AJOL)

    insuffisance rénale chronique étaient les deux principales causes d'échec thérapeutique. Conclusion : Le captopril par voie sublinguale est donc aussi efficace chez le noir africain que chez le caucasien. Dans le contexte de pays en voie de ...

  3. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    oxytétracycline LA) dans le traitement des bovins atteints de péripneumonie contagieuse bovine (PPCB) et de déterminer le risque de transmission de la maladie à partir d'animaux traités. Une transmission expérimentale a été conduite par la mise ...

  4. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... Parasitisme des champs semenciers de cacaoyers par les Loranthaceae dans la localité de Nkoemvone (sud. Cameroun). ONDOUA Joseph Marie1, DIBONG Siegfried Didier (2,3,4)*, TAFFOUO Victor Désiré (2,4), NGOTTA BIYON. Jacques Bruno (2). (1). Département de Botanique et de Physiologie ...

  5. Parasitisme de Dacryodes edulis par le genre Tapinanthus ...

    African Journals Online (AJOL)

    SARAH

    31 août 2013 ... hôtes de Dacryodes edulis alors que les autres ligneux cultivés étaient parasités par Phragmanthera capitata. Le taux moyen de ...... Mistletoes as parasites host specificity and speciation. Trends. Ecology and Evolution 13: 101-105. Peakall R, 1994. Interactions between orchids and ants. In: Orchid ...

  6. Aqueous misdirection following pars plana vitrectomy and silicone oil injection.

    Science.gov (United States)

    Ghoraba, Hammouda H; Ghali, Ali Ahmed; Mansour, Hosam Othman

    2015-01-01

    To report a retrospective series of seven phakic eyes of seven patients suffering from a malignant glaucoma-like syndrome following pars plana vitrectomy and silicone oil (SO) injection. Seven eyes with retinal detachment treated with pars plana vitrectomy with or without scleral buckling with SO tamponade. This was followed by cataract extraction to manage the elevated intraocular pressure (IOP). This was a retrospective review of seven cases that received pars plana vitrectomy and SO with or without scleral buckling for different causes of retinal detachment (three were rhegmatogenous and four were tractional). After a period ranging from 1 week to 1 month, they presented with malignant glaucoma-like manifestations; high IOP, shallow axial anterior chamber, and remarkable decrease of visual acuity. Atropine eye drops and anti-glaucoma medical treatment (topical and systemic) had been tried but failed to improve the condition. Dramatic decrease of IOP and deepening of the axial anterior chamber was observed in all cases in the first postoperative day after phacoemulsification and posterior chamber foldable intraocular lens implantation with posterior capsulotomy. Aqueous misdirection syndrome may be observed following pars plana vitrectomy and SO tamponade. This must be differentiated from other causes of post vitrectomy glaucoma. Cataract extraction with posterior capsulotomy controls the condition.

  7. BOREAS RSS-10 TOMS Circumpolar One-Degree PAR Images

    Science.gov (United States)

    Dye, Dennis G.; Holben, Brent; Nickeson, Jaime (Editor); Hall, Forrest G. (Editor); Smith, David E. (Technical Monitor)

    2000-01-01

    The Boreal Ecosystem-Atmosphere Study (BOREAS) Remote Sensing Science (RSS)-10 team investigated the magnitude of daily, seasonal, and yearly variations of Photosynthetically Active Radiation (PAR) from ground and satellite observations. This data set contains satellite estimates of surface-incident PAR (400-700 nm, MJ/sq m) at one-degree spatial resolution. The spatial coverage is circumpolar from latitudes of 41 to 66 degrees north. The temporal coverage is from May through September for years 1979 through 1989. Eleven-year statistics are also provided: (1) mean, (2) standard deviation, and (3) coefficient of variation for 1979-89. The PAR estimates were derived from the global gridded ultraviolet reflectivity data product (average of 360, 380 nm) from the Nimbus-7 Total Ozone Mapping Spectrometer (TOMS). Image mask data are provided for identifying the boreal forest zone, and ocean/land and snow/ice-covered areas. The data are available as binary image format data files. The PAR data are available from the Earth Observing System Data and Information System (EOSDIS) Oak Ridge National Laboratory (ORNL) Distributed Active Archive Center (DAAC). The data files are available on a CD-ROM (see document number 20010000884).

  8. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet...

  9. Ankaferd Blood Stopper induces apoptosis and regulates PAR1 and ...

    African Journals Online (AJOL)

    Mine Mumcuoglu

    2014-12-16

    Dec 16, 2014 ... Expression analyses of PAR1, EPCR and p21 upon ABS treatment were performed by quantitative real time PCR. Annexin V ... 2014 Production and hosting by Elsevier B.V. on behalf of Ain Shams University. 1. Introduction. Ankaferd Blood ..... effects of Ankaferd as an alternative medicine. Altern Med Rev.

  10. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  11. Evaluation De L'activite Antifongique Par Bioautographie De ...

    African Journals Online (AJOL)

    Evaluation De L'activite Antifongique Par Bioautographie De Quelques Plantes Medicinales De Côte D'ivoire Contre Deux Formes Speciales De Fusarium Oxysporum. ... Fusariosis are among the most devastating diseases in crops, especially in tomato, cotton and banana. This study was carried out in order to identify ...

  12. Can-rupture detection in gas-cooled nuclear reactors; La detection des ruptures de gaine dans les piles nucleaires refroidies par gaz

    Energy Technology Data Exchange (ETDEWEB)

    Roguin, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1965-07-01

    Can-rupture detection (DRG) is one important aspect of pile safety, more particularly so in the case of gas-cooled reactors. A rapid and sure detection constitutes also an improvement as far as the efficiency of electricity-producing nuclear power stations are concerned. Among the numerous can-rupture detection methods, that based on the measurement of the concentration of short-lived fission gases in the heat-carrying fluid has proved to be the most sensitive and the most rapid. A systematic study of detectors based on the electrostatic collection of the daughter products of fission gases has been undertaken with a view to equip the reactors EL 2, G 3, EDF 1, EDF 2 and EDF 3, the gas loops of PEGASE and EL 4. The different parameters are studied in detail in order to obtain a maximum sensitivity and to make it possible to construct detection devices having the maximum operational reliability and requiring the minimum maintenance. The primary applications of these devices are examined in the case of the above-mentioned reactors. (author) [French] La Detection des Ruptures de Gaines (D. R. G.) est un aspect important de la securite des piles et plus particulierement des piles refroidies par un gaz. Une detection rapide et sure constitue aussi un element d'amelioration du rendement des centrales nucleaires productrices d'energie electrique. Parmi les nombreuses methodes de detection des ruptures de gaines, la mesure de la concentration dans le fluide caloporteur des gaz de fission a vie courte s'est revelee comme la plus sensible et la plus rapide. Une etude systematique des detecteurs a collection electrostatique des descendants des gaz de fission a ete entreprise en vue d'equiper les piles EL 2, G 3, EDF 1, EDF 2 et EDF 3, les boucles a gaz de la pile Pegase et la pile EL 4. Les divers parametres sont etudies en detail pour obtenir une sensibilite maximum et permettre la realisation de dispositifs de detection ayant le maximum de securite de

  13. Study of cis- and trans-uranium elements by paper chromatography and electrophoresis; Contribution a l'etude des elements cis- et trans-uraniens par chromatographie sur papier et electrophorese

    Energy Technology Data Exchange (ETDEWEB)

    Clanet, F. [Commissariat a l' Energie Atomique, 92 - Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1968-01-01

    'electrophorese, en chimie minerale, a ete etendu aux elements 90 a 96 en milieux HCl et HNO{sub 3}. Les resultats obtenus portent sur les points suivants: 1) - Caracterisation des etats de valence de Np et de Pu a l'aide de reactions colorees sur les chromatogrammes et les electrophoregrammes. L'alizarine, l'arsenazo-I et le thorin-I permettent de caracteriser la valence IV, tandis que le diphenylcarbazide est specifique de l'etat hexavalent. 2) - Chromatographie sur papier: en utilisant comme eluants des melanges a parts egales de solutions aqueuses de HCl ou de HNO{sub 3} et d'alcools (methanol, ethanol, n-butanol), les R{sub f} des elements 90 a 96 ont ete determines. Certaines conclusions relatives a leur complexation par les ions Cl{sup -} et NO{sub 3}{sup -} ont pu en etre deduites. 3) - Nous avons elabore une technique d'electrophorese sur membrane d'acetate de cellulose afin de separer les especes chargees formees par les elements 90 a 96 dans des solutions HCl et HNO{sub 3} 1 a 12 M. Les courbes de mobilite ont ete tracees. Il decoule de nos resultats que la tendance des elements consideres a former des complexes anioniques s'etablit dans l'ordre des potentiels ioniques, lorsqu'ils sont a l'etat tetravalent; cet ordre est inverse lorsqu'ils sont a la valence III. Les ions Cl{sup -} sont moins complexants que les ions NO{sub 3}{sup -} vis-a-vis de ces elements dans leur etat d'oxydation III et IV, mais on observe le phenomene inverse pour U{sup VI} et Pu{sup VI}. Enfin, la complexation des cations Pu{sup 4+} et PuO{sub 2}{sup 2+} par NO{sub 3}{sup -} suit l'ordre des potentiels ioniques mais a lieu dans l'ordre inverse s'il s'agit d'ions Cl{sup -}. 4) - Diverses applications analytiques sont envisagees: separation les uns des autres des divers elements consideres et separation des etats de valence de Np et de Pu. (auteur)

  14. PH motifs in PAR1&2 endow breast cancer growth.

    Science.gov (United States)

    Kancharla, A; Maoz, M; Jaber, M; Agranovich, D; Peretz, T; Grisaru-Granovsky, S; Uziely, B; Bar-Shavit, R

    2015-11-24

    Although emerging roles of protease-activated receptor1&2 (PAR1&2) in cancer are recognized, their underlying signalling events are poorly understood. Here we show signal-binding motifs in PAR1&2 that are critical for breast cancer growth. This occurs via the association of the pleckstrin homology (PH) domain with Akt/PKB as a key signalling event of PARs. Other PH-domain signal-proteins such as Etk/Bmx and Vav3 also associate with PAR1 and PAR2 through their PH domains. PAR1 and PAR2 bind with priority to Etk/Bmx. A point mutation in PAR2, H349A, but not in R352A, abrogates PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumour growth in vivo and placental extravillous trophoblast (EVT) invasion in vitro. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind the PH domain, reduces mammary tumours and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes.

  15. Comparison of Extrapolation and Interpolation Methods for Estimating Daily Photosynthetically Active Radiation (PAR)

    NARCIS (Netherlands)

    Wu, G.; Skidmore, A.K.; Leeuw, de J.; Liu, X.; Prins, H.H.T.

    2010-01-01

    Measurements of photosynthetically active radiation (PAR), which are indispensable for simulating plant growth and productivity, are generally very scarce. This study aimed to compare two extrapolation and one interpolation methods for estimating daily PAR reaching the earth surface within the

  16. Alpine grassland fPAR change over the Northern Tibetan Plateau from 2002 to 2011

    National Research Council Canada - National Science Library

    CHEN Bao-Xiong ZHANG Xian-Zhou SUN Yu-Fang WANG Jing-Sheng HE Yong-Tao

    2017-01-01

    ...) and traditional in situ fPAR observation for measuring the in situ point fPAR of very short alpine grass vegetation were compared, and the Moderate Resolution Imaging Spectroradiometer (MODIS...

  17. Contamination des eaux de puits traditionnels par les nitrates sur le ...

    African Journals Online (AJOL)

    SARAH

    30 juin 2014 ... Objectif : La contamination des eaux souterraines par les nitrates ... Methodology and Results: the origin of nitrate water from traditional wells of Lobo's watershed was ..... avec celles faites par Hudak (1999) au Texas et Liu et.

  18. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  19. ParCAT: A Parallel Climate Analysis Toolkit

    Science.gov (United States)

    Haugen, B.; Smith, B.; Steed, C.; Ricciuto, D. M.; Thornton, P. E.; Shipman, G.

    2012-12-01

    Climate science has employed increasingly complex models and simulations to analyze the past and predict the future of our climate. The size and dimensionality of climate simulation data has been growing with the complexity of the models. This growth in data is creating a widening gap between the data being produced and the tools necessary to analyze large, high dimensional data sets. With single run data sets increasing into 10's, 100's and even 1000's of gigabytes, parallel computing tools are becoming a necessity in order to analyze and compare climate simulation data. The Parallel Climate Analysis Toolkit (ParCAT) provides basic tools that efficiently use parallel computing techniques to narrow the gap between data set size and analysis tools. ParCAT was created as a collaborative effort between climate scientists and computer scientists in order to provide efficient parallel implementations of the computing tools that are of use to climate scientists. Some of the basic functionalities included in the toolkit are the ability to compute spatio-temporal means and variances, differences between two runs and histograms of the values in a data set. ParCAT is designed to facilitate the "heavy lifting" that is required for large, multidimensional data sets. The toolkit does not focus on performing the final visualizations and presentation of results but rather, reducing large data sets to smaller, more manageable summaries. The output from ParCAT is provided in commonly used file formats (NetCDF, CSV, ASCII) to allow for simple integration with other tools. The toolkit is currently implemented as a command line utility, but will likely also provide a C library for developers interested in tighter software integration. Elements of the toolkit are already being incorporated into projects such as UV-CDAT and CMDX. There is also an effort underway to implement portions of the CCSM Land Model Diagnostics package using ParCAT in conjunction with Python and gnuplot. Par

  20. Attic cholesteatoma with tiny retraction of pars flaccida.

    Science.gov (United States)

    Lee, Jun Ho; Hong, Seok Min; Kim, Chang Woo; Park, Yeo Hoon; Baek, So-Hye

    2015-04-01

    This clinical study was performed to analyze the characteristics of attic cholesteatoma occurring behind a tiny retraction of the pars flaccida, which was classified as Tos type I or II and had an intact pars tensa of the tympanic membrane. The clinical records of patients who underwent tympanomastoidectomy for attic cholesteatoma at a tertiary care referral center (Kangdong Sacred Heart Hospital of Seoul, Korea) between March 2004 and December 2012 were retrospectively reviewed. Eleven patients (five men and six women) who underwent tympanomastoidectomy between March 2004 and December 2012 for attic cholesteatoma occurring behind a tiny attic retraction were included. The mean age of patients was 41.1 years (range 20-58 years) and the mean duration of follow-up was 29.5 months (range 13-52 months). Every patient had a unilateral cholesteatoma, and the opposite side was normal except in one patient. Hearing loss was the most common symptom, followed by earfullness and otalgia. Five patients had type I attic retraction, and six patients had type II attic retraction. No patient had definite scutum erosion. Interestingly, during regular postoperative checkup, one patient was found incidentally for the opposite ear. Six patients had a cholesteatoma sac that was separated from the pars flaccida, whereas in five patients it was in contact with the pars flaccida but was easily separated. Six patients had a limited cholesteatoma within the epitympanum, and five patients had extension beyond the epitympanum. The average air-bone gap was 24.3±10.1dB before the operation and 14.2±6.6dB after the operation. Every patient had an intact tympanic membrane without retraction pocket postoperatively. There was no recurrence of cholesteatoma during follow-up. The rate of attic cholesteatomas occurring behind a tiny retraction of the pars flaccida was 7.7% (11 of 142 patients with attic cholesteatoma). Attic retractions must be followed closely using endoscopy, microscopy, and

  1. Traitements didactiques preventifs d'un type de conceptions erronees en sciences physiques chez des eleves du secondaire

    Science.gov (United States)

    Blondin, Andre

    Dans un contexte constructiviste, les connaissances anterieures d'un individu sont essentielles a la construction de nouvelles connaissances. Quelle qu'en soit la source (certaines de ces connaissances ont ete elaborees en classe, d'autres ont ete elaborees par interaction personnelle de l'individu avec son environnement physique et social), ces connaissances, une fois acquises, constituent les matieres premieres de l'elaboration des nouvelles conceptions de cet individu. Generalement, cette influence est consideree comme positive. Cependant, dans un milieu scolaire ou l'apprentissage de certaines conceptions enchassees dans un programme d'etudes et enterinees par l'ensemble d'une communaute est obligatoire, certaines connaissances anterieures peuvent entraver la construction des conceptions exigees par la communaute. La litterature abonde de tels exemples. Cependant, certaines connaissances anterieures, en soi tout a fait conformes a l'Heritage, peuvent aussi, parce qu'utilisees de facon non pertinente, entraver la construction d'une conception exigee par la communaute. Ici, la litterature nous donne peu d'exemples de ce type, mais nous en fournirons quelques-uns dans le cadre theorique, et ce sera un d'entre eux qui servira de base a nos propos. En effet, une grande proportion d'eleves inscrits a un cours de sciences physiques de la quatrieme secondaire, en reponse a un probleme deja solutionne durant l'annee et redonne lors d'un examen sommatif, "Pourquoi la Lune nous montre-t-elle toujours la meme face?", attribue principalement la cause de ce phenomene a la rotation de la Terre sur son axe. En tant que responsable de l'enseignement de ce programme d'etudes, plusieurs questions nous sont venues a l'esprit, entre autres, comment, dans un contexte constructiviste, est-il possible de reduire chez un eleve, l'impact de cette connaissance anterieure dans l'elaboration de la solution et ainsi prevenir la construction d'une conception erronee? Nous avons teste nos

  2. Developpement d'un catalyseur nickel-alumine efficace pour le reformage de diesel a la vapeur d'eau et etude du systeme reactionnel

    Science.gov (United States)

    Fauteux-Lefebvre, Clemence

    Le developpement de sources d'energie alternatives fiables et efficaces est aujourd'hui une necessite. L' interet dans le reformage d'hydrocarbures liquides est ainsi croissant puisqu'il s'agit d'une voie pour l'alimentation des piles a combustible. Les piles a combustible ont une efficacite pour la conversion d'energie en electricite plus grande que celle des moteurs a combustion et font ainsi partie de la recherche de solution en efficacite energetique. Ces piles consomment de l'hydrogene comme combustible pour produire de l'electricite, d'ou l'interet pour le reformage. En effet, cette reaction permet de produire de l'hydrogene et du monoxyde de carbone (un autre combustible des piles a combustible a electrolyte solide) a partir d'hydrocarbure liquide, notamment le diesel. Les piles pourraient donc etre integrees avec une unite de reformage leur fournissant directement le combustible necessaire a partir de diesel. Dans ce projet de recherche, un nouveau catalyseur de nickel sous forme de spinelle nickel-alumine (spinelle NiAl2O4 sur support d'alumine et de zircone stabilisee avec yttria) a ete developpe et teste en laboratoire pour du reformage de propane, d'hydrocarbures liquides et de diesel, a la vapeur d'eau. Par ailleurs, une methode d'ajout des reactifs novatrice a ete utilisee afin de diminuer la pyrolyse precedant le reformage, en utilisant une emulsion. Les resultats de reformage d'hydrocarbures purs ont montre des concentrations tres pres de l'equilibre thermodynamique et une activite constante sans desactivation du catalyseur ni formation de carbone, et ce avec des ratios H2O/C de moins de 2.5 et des temperatures d'operation variant entre 630 °C et 750 °C. Lors de tests effectues en utilisant du diesel fossile, a 705°C, avec un debit volumique des reactifs de plus de 50 000 cm3gcat-1h-1 et un ratio H2O/C de moins de 2.5, l'activite a ete maintenue pendant plus de 15 heures, malgre une operation en cycles. L'analyse du catalyseur apres cette

  3. The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi

    NARCIS (Netherlands)

    Hovius, Joppe W. R.; Bijlsma, Maarten F.; van der Windt, Gerritje J. W.; Wiersinga, W. Joost; Boukens, Bastiaan J. D.; Coumou, Jeroen; Oei, Anneke; de Beer, Regina; de Vos, Alex F.; van 't Veer, Cornelis; van Dam, Alje P.; Wang, Penghua; Fikrig, Erol; Levi, Marcel M.; Roelofs, Joris J. T. H.; van der Poll, Tom

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can

  4. 78 FR 42584 - Additional Designation of Aluminat, Pars Amayesh Sanaat Kish, Parviz Khaki, Pishro Systems...

    Science.gov (United States)

    2013-07-16

    ... Additional Designation of Aluminat, Pars Amayesh Sanaat Kish, Parviz Khaki, Pishro Systems Research Company... the Treasury and the Attorney General, has determined that Aluminat, Pars Amayesh Sanaat Kish, Parviz..., Parcham Street, Arak, Iran PARS Amayesh Sanaat Kish AKA: PASK AKA: Vacuumkaran AKA: Vacuum Karan AKA...

  5. Five-Port Combined Limbal and Pars Plana Vitrectomy for Infectious Endophthalmitis.

    Science.gov (United States)

    Xu, Kunyong; Chin, Eric K; Almeida, David R P

    2016-01-01

    Pars plana vitrectomy for acute infectious endophthalmitis can be challenging due to severe inflammation in the anterior chamber creating significant media opacity. We describe a surgical technique combining limbal based vitrectomy and pars plana vitrectomy to manage acute infectious endophthalmitis. Limbal based vitrectomy facilitates removal of anterior chamber fibrin and inflammatory membranes for safe and optimal posterior pars plana vitrectomy.

  6. 12 CFR 925.19 - Par value and price of stock.

    Science.gov (United States)

    2010-01-01

    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Par value and price of stock. 925.19 Section... ASSOCIATES MEMBERS OF THE BANKS Stock Requirements § 925.19 Par value and price of stock. The capital stock of each Bank shall be sold at par, unless the Board has fixed a higher price. ...

  7. Neo-Positivist Intrusions, Post-Qualitative Challenges, and PAR's Generative Indeterminacies

    Science.gov (United States)

    Miller, Janet L.

    2017-01-01

    Although committed to PAR's overarching aspirations, many advocates also have noted myriad complexities of engaging in PAR, where ambiguities and disarrays--all kinds of inconclusive evidence--can proliferate. Uncertainties especially can erupt if PAR education-focused projects are positioned, oxymoronically, as expected to produce "high…

  8. Is There an "F" in Your PAR? Understanding, Teaching and Doing Action Research

    Science.gov (United States)

    Lorenzetti, Liza; Walsh, Christine Ann

    2014-01-01

    Participatory Action Research (PAR) is increasingly recognized within academic research and pedagogy. What are the benefits of including feminism within participatory action research and teaching? In responding to this question, we discuss the similarities and salient differences between PAR and feminist informed PAR (FPAR). There are eight themes…

  9. A network of cis and trans interactions is required for ParB spreading

    Science.gov (United States)

    Song, Dan; Rodrigues, Kristen; Graham, Thomas G.W.

    2017-01-01

    Abstract Most bacteria utilize the highly conserved parABS partitioning system in plasmid and chromosome segregation. This system depends on a DNA-binding protein ParB, which binds specifically to the centromere DNA sequence parS and to adjacent non-specific DNA over multiple kilobases in a phenomenon called spreading. Previous single-molecule experiments in combination with genetic, biochemical and computational studies have argued that ParB spreading requires cooperative interactions between ParB dimers including DNA bridging and possible nearest-neighbor interactions. A recent structure of a ParB homolog co-crystallized with parS revealed that ParB dimers tetramerize to form a higher order nucleoprotein complex. Using this structure as a guide, we systematically ablated a series of proposed intermolecular interactions in the Bacillus subtilis ParB (BsSpo0J) and characterized their effect on spreading using both in vivo and in vitro assays. In particular, we measured DNA compaction mediated by BsSpo0J using a recently developed single-molecule method to simultaneously visualize protein binding on single DNA molecules and changes in DNA conformation without protein labeling. Our results indicate that residues acting as hubs for multiple interactions frequently led to the most severe spreading defects when mutated, and that a network of both cis and trans interactions between ParB dimers is necessary for spreading. PMID:28407103

  10. The use aeroplanes and vehicles for prospecting. The technique of the detection radioactivity. The future opened up by the use of the discrimination of energies; Methodes de prospection autoportee et aeroportee. La technique de la detection des rayonnements. Les perspectives offertes par la discrimination des energies

    Energy Technology Data Exchange (ETDEWEB)

    Guitton, J.; Berbezier, J.; Blangy, B.; Lallemant, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1958-07-01

    The idea of installing activity detectors on aeroplanes and vehicles has been widely applied by the CEA since the start of prospecting in the arid and tropical regions of the Communaute Francaise. Three systems of detection have been developed and compared in a systematic manner: a group of 50 G.M. tubes; the sodium iodide scintillator; the plastic scintillator. The sodium iodide scintillator is used as a standard reference; the results are compared by graphical recording. Airborne prospecting is carried out in two stages: the initial flights, which follow a kilometre square network, make possible the discovery of the most likely zones; these likely zones are then examined in greater detail using light aeroplanes or helicopters. The two types of airborne scintillation measuring devices which have been developed by the CEA are described in this article. The practical results obtained during systematic and detailed airborne prospecting campaigns in the Hoggar are described. The difficulty in airborne uranium prospecting is to be able to immediately distinguish while in flight, anomalies caused by uranium from those caused by thorium. (author) [French] L'idee de monter des detecteurs de rayonnements sur des avions ou des vehicules a ete largement appliquee par le CEA des le debut des prospections dans les pays sahariens et tropicaux de la Communaute Fran ise. On a realise et compare d'une maniere systematique trois moyens de detection: groupe de 50 tubes GM; scintillateur d'iodure de sodium, scintillateur plastique. L'appareil de reference sera le scintillateur d'iodure de sodium; les resultats sont compares par enregistrement graphique. La prospection aeroportee se fait en deux etapes; les premiers vols systematiques suivant un quadrillage kilometrique permettent de reperer les zones interessantes; ces dernieres font l'objet d'examens plus detailles effectues en avion leger ou en helicoptere. Dans cet article, on decrit les deux

  11. Preparation of a sinterable beryllium oxide through decomposition of beryllium hydroxide (1963); Preparation d'un oxyde de beryllium frittable par decomposition de l'hydiloxyde (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Bernier, M. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    fortement pollue par le sulfate de beryllium qui ne peut etre elimine meme par lavage prolonge. Nous avons pu remarquer que les differents types d'hydroxyde (gel, {alpha}, {beta}) ont des allures de decomposition differentes qui permettent d'ailleurs de les distinguer et meme de doser les melanges des formes {alpha} et {beta}. Ces varietes transmettent a l'oxyde qui en derive la forme sous laquelle ils ont ete precipites. L'heredite de l'oxyde se manifeste par son comportement au cours de sa preparation et de son frittage. La comparaison des resultats du frittage et des differentes mesures effectuees sur les poudres d'oxyde nous a conduit a conclure que, pour etre frittes sous vide, les oxydes issus d'hydroxyde doivent etre constitues de cristallites dont les dimensions sont comprises entre 0,1 et 0,2 {mu}, leur teneur en sulfate de beryllium etant inferieure a 0,2 pour cent en poids, exprimee en SO{sub 3}, par rapport a BeO. L'oxyde provenant de l'hydroxyde {alpha} precipite en fins agglomerats et renfermant peu de sulfate de beryllium semble etre celui qui repond le mieux aux conditions qui viennent d'etre enoncees. Nous avons d'ailleurs pu constater que ces conditions etaient egalement remplies par l'oxyde issu de la calcination du sulfate de beryllium. (auteur)

  12. Avis 6 sur la formation à et par la recherche

    OpenAIRE

    Centre de Coopération Internationale en Recherche Agronomique pour le Développement

    2015-01-01

    La formation à et par la recherche s’appuie sur la démarche scientifique, les savoirs, les connaissances à transmettre, tout autant que l’acquisition de compétences en gestion de projet, de capacités au travail en équipe, d’une ouverture d’esprit qui favorisera la créativité. Elle doit permettre de prendre conscience de la responsabilité endossée par la communauté scientifique vis-à-vis de la société et de l’environnement, mais aussi préparer l’avenir professionnel de celle ou de celui qu...

  13. La syphilis congenitale revelee par une fracture spontanee

    Directory of Open Access Journals (Sweden)

    Mounia Lakhdar Idrissi

    2011-11-01

    Full Text Available Alors qu�elle est actuellement oubliee dans les pays developpes, la syphilis congenitale se voit encore chez nous faute du depistage antenatal. Ses formes cliniques sont polymorphes et orientent a tord vers d�autres pathologies surtout en periode neonatale. Le diagnostic n�est donc pas toujours facile. La revelation d�une syphilis congenitale par une fracture spontanee est exceptionnellement decrite. Nous rapportons dans ce travail le cas d�un nourrisson de 2 mois ramene en consultation pour limitation douloureuse des mouvements du bras droit. Le diagnostic est evoque sur les donnees radiologiques et confirme par la serologie syphilitique. Le traitement a repose essentiellement sur l�administration de la penicilline G avec une bonne evolution clinique.

  14. Chaos quantique avec des atomes refroidis par laser

    OpenAIRE

    Lignier, Hans; Thommen, Quentin; Chabé, Julien; Delande, Dominique; Garreau, Jean Claude; Szriftgiser, Pascal; Zehnlé, Véronique

    2005-01-01

    Conférence présentée au 5e Colloque "Chaos Temporel et Chaos Spatio-Temporel", Le Havre, décembre 2005; La dynamique des systèmes chaotiques est le sujet de nombreuses études en physique. Après les percées accomplies par Poincaré au début du XXe siècle, les idées se sont fixées avec la découverte par Lorenz dans les années 60 de la ``sensibilité aux conditions initiales'', qui découle de la non linéarité des équations du mouvement. Plusieurs difficultés se présentent cependant quand l'on tent...

  15. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  16. Notre experience de la myelopathie par arthrose cervicale a Dakar ...

    African Journals Online (AJOL)

    ... (p=0,48 > 0,05) ne semblent pas influencer la récupération fonctionnelle post opératoire. Conclusion L'incidence de myélopathie par arthrose cervicale apparaît au Sénégal comme une pathologie sousestimée. La laminectomie décompressive sans instrumentation postérieure constitue notre choix thérapeutique majeur.

  17. Démarginalisation des travailleurs pauvres par le droit | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Démarginalisation des travailleurs pauvres par le droit. Cette subvention appuiera une étude approfondie de la situation, des revendications et des combats juridiques des travailleurs pauvres (plus particulièrement des femmes) membres de l'économie non structurée au Ghana, au Pérou et en Thaïlande. On aura recours à ...

  18. Inondations dans la banlieue de Dakar : vers une adaptation par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Inondations dans la banlieue de Dakar : vers une adaptation par des améliorations du bâti, des infrastructures et de la gouvernance locale. La gestion des inondations représente un des défis majeurs du continent africain en regard des changements climatiques. Une urbanisation effrénée, un étalement urbain hors de ...

  19. Anesthesie topique par oxybuprocaine dans la chirurgie de cataracte

    African Journals Online (AJOL)

    Étude prospective portant sur 100 patients opérés pour cataracte simple stade I, II et III sous anesthésie topique par instillation de quatre gouttes d'Oxybuprocaïne 0.4% collyre, nous avons analysé les complications rencontrées et le confort des patients à l'aide de l'échelle visuelle analogique. La tolérance du patient durant ...

  20. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    Rodríguez Gimeno, Ignacio

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  1. Irrigation endoscopic assisted percutaneous pars repair: technical note.

    Science.gov (United States)

    Soliman, Hesham Magdi

    2016-10-01

    Spondylolysis is a common source of low back pain in children and adolescents. Despite the benign natural history of the pathology, however, it should be noted that as part of conservative management many young individuals are forced to discontinue their routine sports activities. In cases resistant to conservative management, direct repair of a pars defect is considered a safe and effective option in young adults with preserved discs. Recently, some reports of minimally invasive pars repair have been described, aiming at preservation of the paraspinal muscles and improvement of the postoperative course. The study aimed to present a new minimally invasive endoscopic technique for pars repair. This is a technical note. Seven consecutive patients complaining of back pain due to spondylolysis and resistant to conservative management were included. Outcome was assessed using the modified Macnab criteria, and bone union was assessed on postoperative radiographs. Two portals of 0.5 cm were used on each side, 1 cm lateral to the midline. One portal is used for the endoscope and the second for the surgical instruments. Following endoscopic debridement of the defect, the inferior portal was used for percutaneous placement of the Buck screw. There was no source for external funding for this study and no potential conflict of interest to disclose. Outcome was excellent in six cases and good in one case. All patients returned back to their normal level of activities. Complete radiographic union was seen in all patients. The mean period of postoperative hospital stay and follow-up was 8 hours and 21 months, respectively. The irrigation endoscopic technique has previously shown promising results in lumbar discectomy and laminectomy. Similar results were observed in the current study on the ability to achieve minimally invasive pars defect debridement and a smooth postoperative course. This is a pilot study and larger patient series and different surgeons' experience are

  2. Excision Les jeunes changent l'Afrique par les TIC

    International Development Research Centre (IDRC) Digital Library (Canada)

    Encadré 8 - Recherche sur les MGF : des concepts et méthodes à actualiser. 58. Encadré 9 - Faire comme les grands, quand on est jeune. 69. Encadré 10 - Etre un aîné, le rêve. 71. Encadré 11 - Le paradigme transdisciplinaire vu par les jeunes. 78. Encadré 12 - Citoyenneté au féminin/masculin. 83. Encadré 13 - Le projet, ...

  3. Neural crest specification by noncanonical Wnt signaling and PAR-1

    Science.gov (United States)

    Ossipova, Olga; Sokol, Sergei Y.

    2011-01-01

    Neural crest (NC) cells are multipotent progenitors that form at the neural plate border, undergo epithelial-mesenchymal transition and migrate to diverse locations in vertebrate embryos to give rise to many cell types. Multiple signaling factors, including Wnt proteins, operate during early embryonic development to induce the NC cell fate. Whereas the requirement for the Wnt/β-catenin pathway in NC specification has been well established, a similar role for Wnt proteins that do not stabilize β-catenin has remained unclear. Our gain- and loss-of-function experiments implicate Wnt11-like proteins in NC specification in Xenopus embryos. In support of this conclusion, modulation of β-catenin-independent signaling through Dishevelled and Ror2 causes predictable changes in premigratory NC. Morpholino-mediated depletion experiments suggest that Wnt11R, a Wnt protein that is expressed in neuroectoderm adjacent to the NC territory, is required for NC formation. Wnt11-like signals might specify NC by altering the localization and activity of the serine/threonine polarity kinase PAR-1 (also known as microtubule-associated regulatory kinase or MARK), which itself plays an essential role in NC formation. Consistent with this model, PAR-1 RNA rescues NC markers in embryos in which noncanonical Wnt signaling has been blocked. These experiments identify novel roles for Wnt11R and PAR-1 in NC specification and reveal an unexpected connection between morphogenesis and cell fate. PMID:22110058

  4. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA-conjugated vers......-conjugated version (NOTA-AE105) for development of the first (18)F-labeled uPAR positron-emission-tomography PET ligand using the Al(18)F radiolabeling method. In this study, the potential of (18)F-AlF-NOTA-AE105 to specifically target uPAR-positive prostate tumors was investigated....

  5. The Role of Neurosecretory Neurons in the Pars Intercerebralis and Pars Lateralis in Reproductive Diapause of the Blowfly, Protophormia terraenovae

    Science.gov (United States)

    Shiga, S.; Numata, H.

    Microlesions of the brain were made to examine the role of neurosecretory neurons in the pars intercerebralis (PI) and pars lateralis (PL) in the induction of reproductive diapause of the female blowfly Protophormia terraenovae. Under both diapause-inducing (LD 12 : 12, 20° C) and diapause-averting conditions (LD 18 : 6, 25° C), the ovaries invariably failed to develop when the PI was removed. When the PL was removed bilaterally, the ovaries developed in most of the females, irrespective of the rearing conditions. Removal of the PL prevented females from entering reproductive diapause. These results show that certain neurosecretory neurons in the PI are necessary for vitellogenesis, and that the PL contains inhibitory neurons which suppress vitellogenesis during reproductive diapause.

  6. Fármacos, ETEs, e corpos hídricos

    OpenAIRE

    Juliana Cristina Barreiro; Eny Maria Vieira; Quezia Bezerra Cass; Ricardo Wagner Reis Filho

    2007-01-01

    Na última década, especial atenção tem sido dada a presença de compostos farmacêuticos no ambiente aquático; uma vez que o aporte contínuo e a persistência de várias dessas substâncias podem trazer danos irreversíveis à biota. Sendo assim, o desenvolvimento e aplicação de novas tecnologias de tratamento que permitam a remoção ou diminuição desses contaminantes tem sido objeto de interesse na área de saneamento ambiental. Entretanto, a não existência de programas específicos de monitoramento n...

  7. Characterization of a Par j 1/Par j 2 mutant hybrid with reduced allergenicity for immunotherapy of Parietaria allergy.

    Science.gov (United States)

    Bonura, A; Passantino, R; Costa, M A; Montana, G; Melis, M; Bondì, M Luisa; Butteroni, C; Barletta, B; Corinti, S; Di Felice, G; Colombo, P

    2012-03-01

    Parietaria pollen is one of the major cause of pollinosis in the southern Europe. Specific immunotherapy is the only treatment able to modify the natural outcome of the disease restoring a normal immunity against allergens. We designed a recombinant molecule (PjEDloop1) comprised of genetic-engineered variants of the major allergens of the Parietaria pollen (Par j 2/Par j 1). Purity and chemical-physical properties of the derivative were analysed by RP-HPLC chromatography and Photon Correlation Spectroscopy. Immunological activity was evaluated by means of Western blotting, ELISA inhibition and PBMC proliferation assay in 10 Parietaria allergic patients. Basophil activation was studied in six subjects. The immunogenicity of the hybrid was studied looking at the immune responses induced in a mouse model of sensitization. The PjEDloop1 hybrid was produced as a purified recombinant protein with high stability in solution. Western blot, ELISA inhibition and basophil activation test showed that the PjEDloop1 displays a remarkable reduced IgE binding and anaphylactic activity. CD3 reactivity was conserved in all patients. Mice immunization with the rPjEDloop1 induced antibodies and T cell responses comparable to that obtained by the wild type allergens. Such antibodies shared the specificities to rPar j 1 and rPar j 2 with human IgE antibodies. Our results demonstrated that a mutant hybrid expressing genetically engineered forms of the major P. judaica allergens displayed reduced allergenicity and retained T cell reactivity for the induction of protective antibodies in vaccination approaches for the treatment of Parietaria pollinosis. © 2011 Blackwell Publishing Ltd.

  8. Propriétés structurales, optiques et électriques des couches minces ...

    African Journals Online (AJOL)

    Des couches minces de TiO2 dope au cuivre ont ete preparees par la methode Sol-Gel et deposees selon le procede dip-coating sur des substrats en verre. Les proprietes structurales, optiques et electriques des echantillons monocouches dopes 0, 3 et 7 % at. cuivre ont ete analysees par diffraction des ...

  9. PAR Genes: Molecular Probes to Pathological Assessment in Breast Cancer Progression

    Directory of Open Access Journals (Sweden)

    Beatrice Uziely

    2011-01-01

    Full Text Available Taking the issue of tumor categorization a step forward and establish molecular imprints to accompany histopathological assessment is a challenging task. This is important since often patients with similar clinical and pathological tumors may respond differently to a given treatment. Protease-activated receptor-1 (PAR1, a G protein-coupled receptor (GPCR, is the first member of the mammalian PAR family consisting of four genes. PAR1 and PAR2 play a central role in breast cancer. The release of N-terminal peptides during activation and the exposure of a cryptic internal ligand in PARs, endow these receptors with the opportunity to serve as a “mirror-image” index reflecting the level of cell surface PAR1&2-in body fluids. It is possible to use the levels of PAR-released peptide in patients and accordingly determine the choice of treatment. We have both identified PAR1 C-tail as a scaffold site for the immobilization of signaling partners, and the critical minimal binding site. This binding region may be used for future therapeutic modalities in breast cancer, since abrogation of the binding inhibits PAR1 induced breast cancer. Altogether, both PAR1 and PAR2 may serve as molecular probes for breast cancer diagnosis and valuable targets for therapy.

  10. Expression of Partitioning Defective 3 (Par-3 for Predicting Extrahepatic Metastasis and Survival with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Jun-Yang Liou

    2013-01-01

    Full Text Available Partitioning defective 3 (Par-3, a crucial component of partitioning-defective complex proteins, controls cell polarity and contributes to cell migration and cancer cell epithelial-to-mesenchymal transition. However, the clinical relevance of Par-3 in tumor progression and metastasis has not been well elucidated. In this study, we investigated the impact and association of Par-3 expression and clinical outcomes with hepatocellular carcinoma (HCC. We first confirmed that Par-3 was abundantly expressed in HCC cell lines by Western blot analysis. We used immunohistochemistry to analyze the association of Par-3 expression and clinicopathological characteristics in primary and subsequent metastatic tumors of patients with HCC. Par-3 was overexpressed in 47 of 111 (42.3% primary tumors. Increased expression of Par-3 in primary tumors predicted an increased five-year cumulative incidence of extrahepatic metastasis. In addition, multivariate analysis revealed that Par-3 overexpression was an independent risk factor of extrahepatic metastasis. Increased Par-3 expression in primary tumors was associated with poor five-year overall survival rates and was an independent prognostic factor on Cox regression analysis. In conclusion, we show for the first time that increased Par-3 expression is associated with distant metastasis and poor survival rates in patients with HCC. Par-3 may be a novel prognostic biomarker and therapeutic target for HCC.

  11. Effect of PAR-2 Deficiency in Mice on KC Expression after Intratracheal LPS Administration

    Directory of Open Access Journals (Sweden)

    Julie C. Williams

    2011-01-01

    Full Text Available Protease activated receptors (PAR have been shown to play a role in inflammation. PAR-2 is expressed by numerous cells in the lung and has either proinflammatory, anti-inflammatory, or no effect depending on the model. Here, we examined the role of PAR-2 in a model of LPS-induced lung inflammation. We found that PAR-2-deficient mice had significantly less KC expression in bronchial lavage fluid compared with wild-type mice but there was no difference in MIP-2 or TNF-α expression. We also found that isolated alveolar and resident peritoneal macrophages lacking PAR-2 showed a similar deficit in KC after LPS stimulation without differences in MIP-2 or TNF-α. Infiltration of neutrophils and macrophages into the lung following LPS administration was not affected by an absence of PAR-2. Our results support the notion that PAR-2 plays a role in LPS activation of TLR4 signaling in macrophages.

  12. Fragmentation study of isolated and nano-solvated biomolecules induced by collision with multiply charged ions and neutral particles; Etude de la fragmentation de molecules d'interet biologique isolees et nano-solvatees induite par collision avec des ions multicharges et des particules neutres

    Energy Technology Data Exchange (ETDEWEB)

    Bernigaud, V.

    2009-08-27

    les proprietes intrinseques de certaines biomolecules (porphyrines et acides amines), des experiences sur des systemes isoles ont ete effectuees. Les resultats obtenus rendent compte de la grande stabilite des porphyrines lors de l'arrachement ou de l'attachement d'electrons. La dependance des voies de fragmentation induite par les ions multicharges en fonction de l'isomerie de l'alanine a ete demontree. Dans un second temps, la prise en compte d'un environnement modele autour des biomolecules a mis en evidence l'apparition ou la modification des voies de dissociation provoquee par la presence d'autres molecules biologiques (agregats de bases nucleiques) ou de molecules de solvant (eau, methanol, acetonitrile) autour de la biomolecule etudiee. Enfin dans le but de poursuivre ces etudes avec des systemes de plus grande taille, un nouveau dispositif experimental, developpe durant la these et base sur une source electrospray et un quadripoe de selection en masse, est presente. Les tests realises avec ce dispositif et les ameliorations proposees permettent d'envisager, a l'avenir, des etudes sur la dynamique de fragmentation de grands systemes biomoleculaires charges et hydrates provoquee par des ions multicharges de basse energie

  13. Modelisation de l'erosion et des sources de pollution dans le bassin versant Iroquois/Blanchette dans un contexte de changements climatiques

    Science.gov (United States)

    Coulibaly, Issa

    Principale source d'approvisionnement en eau potable de la municipalite d'Edmundston, le bassin versant Iroquois/Blanchette est un enjeu capital pour cette derniere, d'ou les efforts constants deployes pour assurer la preservation de la qualite de son eau. A cet effet, plusieurs etudes y ont ete menees. Les plus recentes ont identifie des menaces de pollution de diverses origines dont celles associees aux changements climatiques (e.g. Maaref 2012). Au regard des impacts des modifications climatiques annonces a l'echelle du Nouveau-Brunswick, le bassin versant Iroquois/Blanchette pourrait etre fortement affecte, et cela de diverses facons. Plusieurs scenarios d'impacts sont envisageables, notamment les risques d'inondation, d'erosion et de pollution a travers une augmentation des precipitations et du ruissellement. Face a toutes ces menaces eventuelles, l'objectif de cette etude est d'evaluer les impacts potentiels des changements climatiques sur les risques d'erosion et de pollution a l'echelle du bassin versant Iroquois/Blanchette. Pour ce faire, la version canadienne de l'equation universelle revisee des pertes en sol RUSLE-CAN et le modele hydrologique SWAT ( Soil and Water Assessment Tool) ont ete utilises pour modeliser les risques d'erosion et de pollution au niveau dans la zone d'etude. Les donnees utilisees pour realiser ce travail proviennent de sources diverses et variees (teledetections, pedologiques, topographiques, meteorologiques, etc.). Les simulations ont ete realisees en deux etapes distinctes, d'abord dans les conditions actuelles ou l'annee 2013 a ete choisie comme annee de reference, ensuite en 2025 et 2050. Les resultats obtenus montrent une tendance a la hausse de la production de sediments dans les prochaines annees. La production maximale annuelle augmente de 8,34 % et 8,08 % respectivement en 2025 et 2050 selon notre scenario le plus optimiste, et de 29,99 % en 2025 et 29,72 % en 2050 selon le scenario le plus pessimiste par rapport a celle

  14. Caracterisation et transformation par hydroviscoreduction du brut lourd de Doba/Tchad: Strategie de pompage par pipeline

    Science.gov (United States)

    Dehkissia, Soumaine

    Le projet de la these est defini par rapport a la recente exploitation commerciale du brut lourd de Doba, une region du Tchad, pays enclave d'ou le brut ainsi produit doit etre achemine par pipeline. Le but dans ce travail est de caracteriser ce brut et de determiner une strategie thermique de transformation en vue de reduire de la facon la plus economique, la viscosite du brut pour permettre son transport par pipeline. Concernant la partie caracterisation, nous avons utilise entre autres, un rheometre rotatif et des analyseurs (LECO CHN-2000 & LECO S-144DR Elemental Analyzers) pour evaluer respectivement la viscosite et les elements tels que C, H, N, O, S. Sur la base des methodes de transformation disponibles, nous avons determine une strategie simple de transformation thermique par hydroviscoreduction , strategie dans laquelle, la fraction legere du brut comme le naphta (80--180°C), pourrait constituer la source d'hydrogene a utiliser. Le brut de Doba, a une faible teneur en soufre (0.14%) et sa densite specifique de 0.940 a 15.6°C, soit 18.8° API, le classe parmi les bruts lourds. Outre le point initial se situant a 85°C, la distillation du brut a revele que la fraction distillant avant 250°C ne represente que 10% (v/v) et que le craquage thermique du substrat debute a 300°C. Par ailleurs, outre son caractere Newtonien, les densites specifiques de la fraction lourde de l'essence (100--200°C) et de la fraction distillant au-dessus 350°C, etant respectivement de 0.813 (0.813 > 0.800) et de 0.951 (0.930 vieillissement meme apres deux mois, ce qui correspond au temps de sejour du brut dans le pipeline. L'etude montre aussi que les asphaltenes du brut traite en absence d'un catalyseur sont moins aromatiques que ceux du brut non-traite.

  15. The ab initio equation of state of hydrogen in the warm dense matter and its application to the implosion of targets for the inertial confinement fusion; Equation d'etat ab initio de l'hydrogene dans la matiere dense et tiede et application a l'implosion de cibles pour la fusion par confinement inertiel

    Energy Technology Data Exchange (ETDEWEB)

    Caillabet, L.

    2011-03-25

    interactions a N corps dont les effets sont importants dans la WDM. Au contraire, les methodes de calcul ab initio s'affranchissent de ces approximations en resolvant de maniere exacte (ou presque) le probleme quantique a N corps et sont donc particulierement pertinentes dans ce domaine. Dans la premiere partie de cette these, nous decrivons comment nous avons construit une table d'EoS multi-phase de l'hydrogene, a partir de methodes de calcul ab initio dans le domaine de la WDM. Nous montrons notamment que cette EoS est en tres bon accord avec la plupart des donnees experimentales disponibles (Hugoniot principale, vitesse du son dans le fluide moleculaire, courbe de fusion a basse pression, mesures de chocs multiples). Dans la deuxieme partie, nous presentons une application directe de notre EoS en montrant son influence sur les criteres d'allumage et de combustion de deux types de cibles pour la FCI: une cible auto-allumante qui sera utilisee sur le Laser MegaJoule (LMJ), et une cible destinee a l'allumage par choc. Nous montrons notamment que l'optimisation de l'impulsion laser permettant de maximiser l'energie thermonucleaire degagee par les cibles est fortement dependante de la precision de l'EoS dans le domaine de couplage et de degenerescence forts. (auteur)

  16. Development and validation of calculation schemes dedicated to the interpretation of small reactivity effects for nuclear data improvement; Developpement et validation de schemas de calcul dedies a l'interpretation des mesures par oscillation pour l'amelioration des donnees nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Gruel, A.

    2011-10-24

    afin d'obtenir des informations pertinentes sur les donnees nucleaires de base. L'enjeu de cette these est le developpement d'un schema de calcul de reference, dont les incertitudes sont clairement identifiees et quantifiees, permettant l'interpretation des mesures par oscillation. Dans ce document plusieurs methodes de calcul de ces faibles effets en reactivite sont presentees, basees sur des codes de calculs neutroniques deterministes et/ou stochastiques. Ces methodes sont comparees sur un benchmark numerique, permettant leur validation par rapport a un calcul de reference. Trois applications sont ici presentees dans le detail: une methode purement deterministe utilisant la theorie des perturbations exacte pour la qualification des sections efficaces des principaux produits de fission en REP, dans le cadre d'etudes sur l'estimation de la perte du reactivite du combustible au cours du cycle; une methode hybride, basee sur un calcul stochastique et la theorie des perturbations exacte, permet d'obtenir un retour precis sur les donnees nucleaires de bases d'isotopes, dans notre cas l'{sup 241}Am; et enfin, une troisieme methode, reposant sur un calcul perturbatif Monte Carlo, est utilisee pour une etude de conception

  17. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  18. Turbidez e cloro residual livre na monitoração de ETE tipo tanque séptico seguido de filtro anaeróbio - doi: 10.4025/actascitechnol.v33i4.9603 Turbidity and free residual chlorine for monitoring plants comprised by septic tank followed by anaerobic filter

    Directory of Open Access Journals (Sweden)

    Raimundo Oliveira de Souza

    2011-09-01

    Full Text Available A avaliação dos dados agrupados da monitoração de 16 ETEs do tipo tanque séptico (TSEP seguido por filtro anaeróbio (FAN mostrou remoção média global de 55% para DQO e SST. O desempenho alcançado foi abaixo do sugerido pela literatura, porém compatível com o de estudos recentes sobre sistemas em escala real no país. A remoção média global de bactérias do grupo coliforme, após desinfecção com solução de hipoclorito de sódio, foi de 3,0 unidades de log. Remoção mais elevada ocorreu com Escherichia coli como indicador (3,5 logs. Em geral, as maiores remoções de coliformes foram alcançadas com concentrações de cloro residual livre (CRL variando de 2,0 a 2,5 mg L-1. Os resultados mostraram a aplicabilidade da turbidez para estimar concentrações de SST e DQO no efluente tratado. Observou-se também que a concentração de CRL é útil para estimar as concentrações de bactérias do grupo coliforme.Grouped monitoring data of 16 wastewater treatment plants was investigated. The plants were comprised by septic tanks followed by anaerobic filters and effluent disinfection with sodium hypochlorite. Removal of COD and total suspended solids was about 55%. This number was below values observed by the literature. However, the results were in accordance with recent findings in Brazilian full-scale plants. Coliform removal was about 3.0 log units with better results for Escherichia coli (3.5 logs. Best results were achieved with free residual chorine concentrations ranging from 2.0 to 2.5 mg L-1. Findings showed that turbidity is a useful parameter to estimate COD and TSS concentrations in the treated effluent. Free residual chlorine may also be applied to estimate coliform numbers.

  19. Transcriptional profiling of ParA and ParB mutants in actively dividing cells of an opportunistic human pathogen Pseudomonas aeruginosa.

    Directory of Open Access Journals (Sweden)

    Aneta A Bartosik

    Full Text Available Accurate chromosome segregation to progeny cells is a fundamental process ensuring proper inheritance of genetic material. In bacteria with simple cell cycle, chromosome segregation follows replication initiation since duplicated oriC domains start segregating to opposite halves of the cell soon after they are made. ParA and ParB proteins together with specific DNA sequences are parts of the segregation machinery. ParA and ParB proteins in Pseudomonas aeruginosa are important for optimal growth, nucleoid segregation, cell division and motility. Comparative transcriptome analysis of parA null and parB null mutants versus parental P. aeruginosa PAO1161 strain demonstrated global changes in gene expression pattern in logarithmically growing planktonic cultures. The set of genes similarly affected in both mutant strains is designated Par regulon and comprises 536 genes. The Par regulon includes genes controlled by two sigma factors (RpoN and PvdS as well as known and putative transcriptional regulators. In the absence of Par proteins, a large number of genes from RpoS regulon is induced, reflecting the need for slowing down the cell growth rate and decelerating the metabolic processes. Changes in the expression profiles of genes involved in c-di-GMP turnover point out the role of this effector in such signal transmission. Microarray data for chosen genes were confirmed by RT-qPCR analysis. The promoter regions of selected genes were cloned upstream of the promoter-less lacZ gene and analyzed in the heterologous host E. coliΔlac. Regulation by ParA and ParB of P. aeruginosa was confirmed for some of the tested promoters. Our data demonstrate that ParA and ParB besides their role in accurate chromosome segregation may act as modulators of genes expression. Directly or indirectly, Par proteins are part of the wider regulatory network in P. aeruginosa linking the process of chromosome segregation with the cell growth, division and motility.

  20. Validation of MODIS and GEOV1 fPAR Products in a Boreal Forest Site in Finland

    Directory of Open Access Journals (Sweden)

    Titta Majasalmi

    2015-01-01

    Full Text Available Remote sensing of the fraction of absorbed Photosynthetically Active Radiation (fPAR has become a timely option to monitor forest productivity. However, only a few studies have had ground reference fPAR datasets containing both forest canopy and understory fPAR from boreal forests for the validation of satellite products. The aim of this paper was to assess the performance of two currently available satellite-based fPAR products: MODIS fPAR (MOD15A2, C5 and GEOV1 fPAR (g2_BIOPAR_FAPAR, as well as an NDVI-fPAR relationship applied to the MODIS surface reflectance product and a Landsat 8 image, in a boreal forest site in Finland. Our study area covered 16 km2 and field data were collected from 307 forest plots. For all plots, we obtained both forest canopy fPAR and understory fPAR. The ground reference total fPAR agreed better with GEOV1 fPAR than with MODIS fPAR, which showed much more temporal variation during the peak-season than GEOV1 fPAR. At the chosen intercomparison date in peak growing season, MODIS NDVI based fPAR estimates were similar to GEOV1 fPAR, and produced on average 0.01 fPAR units smaller fPAR estimates than ground reference total fPAR. MODIS fPAR and Landsat 8 NDVI based fPAR estimates were similar to forest canopy fPAR.

  1. Parálisis de convergencia Convergence pals

    Directory of Open Access Journals (Sweden)

    Teresita de J Méndez Sánchez

    2010-01-01

    Full Text Available La parálisis de convergencia se caracteriza por la imposibilidad de la convergencia en la mirada próxima, con diplopía horizontal cruzada a partir de 1 metro, con aducción normal. La parálisis de la convergencia es una condición distinta de la insuficiencia de la convergencia y normalmente secundaria a una lesión intracraneal. Acude paciente de 12 años de edad por presentar diplopía horizontal de cerca ± 1 metro de 3 meses de evolución, cefalea, lagrimeo y fotofobia. La impresión diagnóstica fue parálisis de convergencia. En los estudios neurológicos solo se encontró implantación baja de las amígdalas cerebrales. Aún no se precisa la etiología aunque se recoge el antecedente de un traumatismo craneal sin relevancia por la familia.The convergence paralysis is characterized by impossible convergence in the near sight, with crossed horizontal diplopia at one meter distance and normal adduction. The convergence paralysis is a condition different from the inadequate convergence and usually secondary to intracranial lesion. A 12-years old patient went to the hospital because he had suffered horizontal diplopia in near sight (± 1 meter for 3 months, migraine, watering and photophobia. The definitive diagnosis was convergence paralysis. In the neurological studies, the low placing of the tonsils of cerebellum was the only finding. The etiology of this disorder is not determined yet; although there is some history of head trauma to which the family did not pay enough attention.

  2. Is PAR a Good Investment? Understanding the Costs and Benefits of Teacher Peer Assistance and Review Programs

    Science.gov (United States)

    Papay, John P.; Johnson, Susan Moore

    2012-01-01

    Peer Assistance and Review (PAR) is a local labor-management initiative designed to improve teacher quality. In PAR, expert "consulting teachers" mentor, support, and evaluate novice and underperforming veteran teachers. Evaluations under PAR can lead to dismissals. The authors examine the costs and benefits of PAR, both financial and…

  3. The PAR complex regulates pulsed actomyosin contractions during amnioserosa apical constriction in Drosophila.

    Science.gov (United States)

    David, Daryl J V; Tishkina, Alisa; Harris, Tony J C

    2010-05-01

    Apical constriction is a major mechanism underlying tissue internalization during development. This cell constriction typically requires actomyosin contractility. Thus, understanding apical constriction requires characterization of the mechanics and regulation of actomyosin assemblies. We have analyzed the relationship between myosin and the polarity regulators Par-6, aPKC and Bazooka (Par-3) (the PAR complex) during amnioserosa apical constriction at Drosophila dorsal closure. The PAR complex and myosin accumulate at the apical surface domain of amnioserosa cells at dorsal closure, the PAR complex forming a patch of puncta and myosin forming an associated network. Genetic interactions indicate that the PAR complex supports myosin activity during dorsal closure, as well as during other steps of embryogenesis. We find that actomyosin contractility in amnioserosa cells is based on the repeated assembly and disassembly of apical actomyosin networks, with each assembly event driving constriction of the apical domain. As the networks assemble they translocate across the apical patch of PAR proteins, which persist at the apical domain. Through loss- and gain-of-function studies, we find that different PAR complex components regulate distinct phases of the actomyosin assembly/disassembly cycle: Bazooka promotes the duration of actomyosin pulses and Par-6/aPKC promotes the lull time between pulses. These results identify the mechanics of actomyosin contractility that drive amnioserosa apical constriction and how specific steps of the contractile mechanism are regulated by the PAR complex.

  4. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  5. PAR-2 expression in the gingival crevicular fluid reflects chronic periodontitis severity

    Directory of Open Access Journals (Sweden)

    Henrique FUKUSHIMA

    Full Text Available Abstract Recent studies investigating protease-activated receptor type 2 (PAR-2 suggest an association between the receptor and periodontal inflammation. It is known that gingipain, a bacterial protease secreted by the important periodontopathogen Porphyromonas gingivalis can activate PAR-2. Previous studies by our group found that PAR-2 is overexpressed in the gingival crevicular fluid (GCF of patients with moderate chronic periodontitis (MP. The present study aimed at evaluating whether PAR-2 expression is associated with chronic periodontitis severity. GCF samples and clinical parameters, including plaque and bleeding on probing indices, probing pocket depth and clinical attachment level, were collected from the control group (n = 19 at baseline, and from MP patients (n = 19 and severe chronic periodontitis (SP (n = 19 patients before and 6 weeks after periodontal non-surgical treatment. PAR-2 and gingipain messenger RNA (mRNA in the GCF of 4 periodontal sites per patient were evaluated by Reverse Transcription Polymerase Chain Reaction (RT-qPCR. PAR-2 and gingipain expressions were greater in periodontitis patients than in control group patients. In addition, the SP group presented increased PAR-2 and gingipain mRNA levels, compared with the MP group. Furthermore, periodontal treatment significantly reduced (p <0.05 PAR-2 expression in patients with periodontitis. In conclusion, PAR-2 is associated with chronic periodontitis severity and with gingipain levels in the periodontal pocket, thus suggesting that PAR-2 expression in the GCF reflects the severity of destruction during periodontal infection.

  6. GESTION "PAR" LES COMPETENCES ET POSITIONNEMENT DU CONTROLE DE GESTION ?

    OpenAIRE

    Rouby, Evelyne; Guy SOLLE

    2002-01-01

    International audience; Cet article a pour but de contribuer à une définition des contours du concept de "gestion par les compétences". De notre point de vue, ce concept relèverait des mêmes principes que la compétence organisationnelle à savoir les principes "systémique, de finalité, de spécificité, de visibilité et de reconnaissance, dynamique et cumulatif". Il consisterait à en assurer l'interaction dynamique entre les niveaux stratégiques et opérationnels et selon des cycles temporels dif...

  7. Caso práctico parálisis cerebral

    OpenAIRE

    Marcos Gómez, Sergio; Queimadelos Navarro, Sofía; Rodríguez Martín, Samuel; Sañudo Herrero, Alba

    2016-01-01

    El presente trabajo está enfocado al área psicomotor, siguiendo las bases de la intervención de Atención Temprana, desde el campo de la Terapia Ocupacional en la afectación de Parálisis Cerebral Infantil (PCI). El tratamiento empleado está dirigido a potenciar la funcionalidad del miembro afecto, para facilitar al paciente su desempeño en las Actividades de la Vida Diaria, Ocio y Tiempo Libre. Tras llevar a cabo la intervención, se realizó una recogida de datos y se analizó si los objet...

  8. INFECTION VIH REVELEE PAR UN ABCES UNILATERAL DU

    African Journals Online (AJOL)

    chez les sujets immunodéprimés en rapport avec l'épidémie du SIDA. Cet article rapporte le cas d'un patient dont l'infection à VIH a été révélée par un abcès primitif du psoas. OBSERVATION. Il s'agit d'un patient âgé de 25 ans, célibataire, artisan de profession à Marrakech, hétéro-sexuel, ayant eu des rapports sexuels.

  9. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  10. Analysis of clinical features and visual outcomes of pars planitis.

    Science.gov (United States)

    Berker, Nilufer; Sen, Emine; Elgin, Ufuk; Atilgan, Cemile Ucgul; Dursun, Erdem; Yilmazbas, Pelin

    2017-04-07

    To evaluate the demographic characteristics, clinical features, treatment and outcomes of patients with pars planitis in a tertiary referral center in Turkey. Medical records of patients with pars planitis were retrospectively reviewed. The data including demographic and ocular features and treatment outcomes were recorded. The distribution of clinical findings and complications were evaluated according to age and gender groups. The changes in final BCVA compared to the initial BCVA were noted. Statistical analysis was performed using SPSS software (Version 18.0, SPSS Inc., Chicago, USA). Twenty-seven patients (54 eyes) were included in this study. 16 patients were male (59.3%), and 11 were female (40.7%). Mean age at diagnosis was 12.84 ± 8.26 (range 4-36) years. Mean follow-up period was 61.3 ± 52.15 (range 9-172) months. Mean BCVA was 0.58 ± 0.36 (range 0.03-1.00) (0.40 ± 0.45 logMAR) at presentation, and 0.81 ± 0.28 (range 0.10-1.00) (0.14 ± 0.27 logMAR) at final visit (P = 0.001). Vitreous inflammation (100%), vitreous haze (92.6%), snowballs (74.1%), snowbanks (66.7%), anterior chamber cells (66.7%) and peripheral retinal vascular sheathing (48.1%) were the most common presentations. Ocular complications included vitreous condensation (51.9%), cystoid macular edema (22.2%), cataract (18.5%), inferior peripheral retinal detachment (11.1%), glaucoma (5.6%) and vitreous hemorrhage (3.7%). Treatments included topical, periocular, intravitreal and systemic corticosteroids, immunosuppressives, peripheral laser photocoagulation and pars plana vitrectomy when needed. Pars planitis is an idiopathic chronic intermediate uveitis mostly affecting children and adolescents. In spite of its chronic nature with high potential of causing ocular complications, adequate treatment and close follow-up lead to favorable visual outcomes.

  11. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  12. Pollution atmospherique par emission de gaz d'echappement des ...

    African Journals Online (AJOL)

    La pollution atmosphérique a été pendant longtemps considérée comme un mal propre aux pauvres mais de nos jours, elle n'épargne ni pays africains, ni pays européens et devient un problème mondial de santé. L'objectif du présent travail est d'étudier la pollution atmosphérique engendrée par les gaz d'échappement ...

  13. Electronic device for measuring the polarization parameter in the {pi}{sup -}p {yields} {pi}{sup 0}n charge exchange reaction on a polarized proton target; Un appareillage electronique destine a la mesure du parametre de polarisation dans la reaction d'echange de charge {pi}{sup -}p {yields} {pi}{sup 0}n sur cible de protons polarises

    Energy Technology Data Exchange (ETDEWEB)

    Brehin, S. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1967-12-15

    An electronic apparatus has been constructed to measure the polarization parameter P{sub 0}(t) in {pi}{sup -}p {yields} {pi}{sup 0}n charge exchange scattering at 5.9 GeV/c and 11,2 GeV/c on polarized proton target. This device insures triggering of a heavy plate spark chamber, allowing visualisation of {gamma} rays from the {pi}{sup 0} decays when the associated neutron offers suitable characteristics in direction and energy. The neutron is detected by an array of 32 counters and his energy is measured by a time of flight method. Electronic circuits of this apparatus are described as test and calibration methods used. (author) [French] Un appareillage electronique a ete realise pour mesurer le parametre de polarisation P{sub 0}(t) dans la reaction d'echange de charge {pi}{sup -}p {yields} {pi}{sup 0}n a 5,9 GeV/c et 11,2 GeV/c sur une cible de protons polarises. Ce dispositif assure le declenchement d'une chambre a etincelles a plaques lourdes, permettant de visualiser les {gamma} de desitegration du {pi}{sup 0}, lorsque le neutron associe presente les caracteristiques convenables en direction et en energie. Le neutron est detecte par un ensemble de 32 compteurs et son energie est mesuree par une methode de temps de vol. Les circuits composant cet appareillage sont decrits ainsi que les methodes d'etalonnage et de verification utilisees. (auteur)

  14. Systematic study of plasma and serum proteins in the pig; Etude systematique des proteines plasmatiques et seriques du porc

    Energy Technology Data Exchange (ETDEWEB)

    Daburon, F.; Nizza, P.; Hatchikian, C.; Schmidt, J.-P. [Commissariat a l' Energie Atomique (France)

    1966-07-01

    This work has been carried out in the framework of the determination of the physiological constants of a normal pig. The aim was to study the serum and plasma proteins of this animal species, the ultimate object being to discover whether the qualitative and quantitative changes in these proteins can make a significant contribution to the establishment of a biological dosimetry for irradiated pigs. The serum and plasma from a normal pig were analyzed first by various simple electrophoretic methods and then by immuno-electrophoresis. As a result of the particular characteristics of pig serum we have gradually been led to make numerous modifications to the techniques used for human serums or for those of small laboratory animals. Much careful work and patience were required in order to obtain reproducible results. (authors) [French] Ce travail se situe dans le cadre de la determination des constantes physiologiques du porc normal. il s'agissait de proceder a l'etude des proteines seriques et plasmatiques de cette espece animale, le but ulterieur etant de savoir si les modifications qualitatives et quantitatives de ces proteines pourront representer une contribution valable a l'etablissement d'une dosimetrie biologique chez le porc irradie. Le serum et le plasma du porc normal ont ete analyses d'abord par diverses methodes electrophoretiques simples puis par immunoelectrophorese. Les caracteristiques particulieres du serum de porc nous ont conduits a apporter progressivement de nombreuses modifications aux techniques utilisees pour des serums humains ou de petits animaux de laboratoire. L'obtention de resultats reproductible a exige beaucoup de patience et de minutie. (auteurs)

  15. Devenir De l'azote de L'engrais enrichi au n applique au tournesol ...

    African Journals Online (AJOL)

    L'utilisation de I' azote de I' engrais par la culture de toumesol a ete appreciee par Ia determination du coefficient d'utilisation apparent (CUA) estime par Ia methode de difference et du coefficient d'utilisation reel (CUR) estime par Ia methode isotopique. 80 kg N ha-1 a 4.87% d'atomes en exces de 15N ont ete appliques au ...

  16. Apprentissage de Dictionnaires Multivariés et Décomposition Parcimonieuse Invariante par Translation et par Rotation 2D

    OpenAIRE

    Barthélemy, Quentin; Larue, Anthony; Mayoue, Aurélien; Mercier, David; MARS, Jerome

    2011-01-01

    National audience; Cet article présente le Multivariate Dictionary Learning Algorithm qui apprend en ligne les structures élémentaires associées à un ensemble de signaux multivariés. Une fois apprises, le Multivariate Orthogonal Matching Pursuit décompose tous les signaux de cet ensemble avec parcimonie. Ces méthodes sont spécifiées dans le cas d'invariance par rotation qui produit un dictionnaire restreint de noyaux. Nos méthodes sont appliquées à des données d'écriture manuscrite, afin d'ex...

  17. PhyloPars: estimation of missing parameter values using phylogeny.

    Science.gov (United States)

    Bruggeman, Jorn; Heringa, Jaap; Brandt, Bernd W

    2009-07-01

    A wealth of information on metabolic parameters of a species can be inferred from observations on species that are phylogenetically related. Phylogeny-based information can complement direct empirical evidence, and is particularly valuable if experiments on the species of interest are not feasible. The PhyloPars web server provides a statistically consistent method that combines an incomplete set of empirical observations with the species phylogeny to produce a complete set of parameter estimates for all species. It builds upon a state-of-the-art evolutionary model, extended with the ability to handle missing data. The resulting approach makes optimal use of all available information to produce estimates that can be an order of magnitude more accurate than ad-hoc alternatives. Uploading a phylogeny and incomplete feature matrix suffices to obtain estimates of all missing values, along with a measure of certainty. Real-time cross-validation provides further insight in the accuracy and bias expected for estimated values. The server allows for easy, efficient estimation of metabolic parameters, which can benefit a wide range of fields including systems biology and ecology. PhyloPars is available at: http://www.ibi.vu.nl/programs/phylopars/.

  18. Lumbar vertebral body and pars fractures following laminectomy.

    Science.gov (United States)

    Yadhati, Akshay; Kurra, Swamy; Tallarico, Richard A; Lavelle, William F

    2017-02-01

    A 56-year-old alcoholic male incurred L5 vertebral body and bilateral L4 pars fractures with progressive L4 on L5 anterolisthesis following low-energy falls while intoxicated. Recently, he had a L3-S1 laminectomy for lumbar spinal stenosis with claudication. Preoperative imaging and radiographs were negative for pars defects and instability, so an isolated decompressive surgery was performed. Following low-energy falls, his outpatient work-up revealed fractures through the bilateral L4 pedicles and posterior third of L5 vertebral body, with recurrence of axial back pain and bilateral lower extremity radiculopathy. He underwent revision decompression from L4-S1 and posterior instrumented fusion with transforaminal lumbar interbody fusion performed at each revised level. His axial back pain and radiculopathy improved postoperatively. Instability of a lumbar spine fracture pattern can be due to the remote or prior iatrogenic disruption of the posterior ligamentous complex. Our patient benefitted from surgery and his low back pain was resolved.

  19. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  20. Basic isoforms of Par o 1, the major allergen of Parietaria officinalis pollen.

    Science.gov (United States)

    Coscia, M R; Ruffilli, A; Oreste, U

    1995-11-01

    We describe a group of basic isoforms of Par o 1 (cumulatively referred to as Par o 1b), purified by anion-exchange chromatography. The allergenic activity of Par o 1b was compared with that of the acidic isoform (Par o 1a) by RAST inhibition. Par o 1b showed a cathodic mobility in crossed immunoelectrophoresis. It was found to be homogeneous in SDS-PAGE and SE-HPLC (14.5 kDa), and heterogeneous in PAG-IEF, yielding five IgE-binding bands with pI ranging between 7.9 and 9.6 PAG-IEF individual components were isolated by cation-exchange HPLC. The N-terminal amino acid sequence of the main component (pI 8.8) was determined and found to be similar to that of Par o 1a.

  1. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  2. The activity of {gamma}-emitters as measured by ionisation chambers the determination of the specific emission coefficient {gamma} for some radio-elements (1961); Mesure de l'activite des emetteurs {gamma} par chambre d'ionisation. Determination du coefficient specifique d'emission {gamma} de quelques radioelements (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Engelmann, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-06-15

    chambre d'ionisation gamma, permettant soit de mesurer l'activite de sources radioactives, soit de determiner le coefficient specifique d'emission {gamma} (ou coefficient K) d'un radioelement determine. Les chambres d'ionisation etudiees appartiennent a deux categories: chambre-cavites en graphite, et chambres a puits {gamma}. Pour les mesures effectuees avec une chambre-cavite, on a calcule les differents facteurs do correction dont il faut tenir compte, en particulier les corrections de geometrie et d'hygrometrie. Les corrections d'absorption et d'autoabsorption ont amene a introduire la notion 'd'energie efficace {gamma}' d'un radioelement. Dans le cas des chambres a puits, on a montre qu'une forme appropriee des 'electrodes permettait d'ameliorer leurs performances. Une des chambres decrites permet la mesure des emetteurs {beta} par le rayonnement de freinage associe. Pour la determination du coefficient K de quelques radioelements, il s'est avere commode d'utiliser une chambre a puits a parois de graphite, les mesures etant effectuees par comparaison avec un etalon de radium. La validite de la methode a ete verifiee avec quelques radioelements pour lesquels la valeur du coefficent K etait deja bien connue ({sup 24}Na, {sup 60}Co, {sup 131}I, {sup 198}Au). Pour d'autres radioelements, les valeurs suivantes ont ete obtenues (exprimees en r cm{sup 3} mc{sup 1} h{sup 1}): {sup 51}Cr: 0,18; {sup 56}Mn: 8,8; {sup 65}Zn: 3,05; {sup 124}Sb: 9,9; {sup 134}Cs: 9,3; {sup 137}Cs: 3,35; {sup 141}Ce: 0,46; {sup 170}Tm: 0,023; {sup 192}Ir: 24,9; {sup 203}Hg: 1,18; Ces valeurs ont ete corrigees de la contribution qu'apportent a la dose les rayonnements de fluorescence eventuellement emis par la source, sauf dans le cas du {sup 170}Tm. Dans la derniere partie de ce travail, on a compare les performances des differents dispositifs electrometriques utilises. (auteur)

  3. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  4. Traitement de la margine brute d'huile d'olive par distillation suivi de ...

    African Journals Online (AJOL)

    SARAH

    31 juil. 2014 ... Traitement de la margine brute d'huile d'olive par distillation suivi de neutralisation par chaux. 6867 ... Mots clés : margine d'huile d'olive, caractérisation, distillation, neutralisation. The treatment of olive oil mill .... a été déterminée selon la méthode standard (APHA 1992) par une oxydation de la matière.

  5. Alpine grassland fPAR change over the Northern Tibetan Plateau from 2002 to 2011

    Directory of Open Access Journals (Sweden)

    Bao-Xiong Chen

    2017-06-01

    Full Text Available In this study, two different methods including Digital Camera and Reference Panel (DCRP and traditional in situ fPAR observation for measuring the in situ point fPAR of very short alpine grass vegetation were compared, and the Moderate Resolution Imaging Spectroradiometer (MODIS fPAR products were evaluated and validated by in situ point data on the alpine grassland over the Northern Tibetan Plateau, which is sensitive to climate change and vulnerable to anthropogenic activities. Results showed that the MODIS alpine grassland fPAR product, examined by using DCRP, and traditional in situ fPAR observation had a significant relationship at the spatial and temporal scales. The decadal MODIS fPAR trend analysis showed that, average growing season fPAR increased by 1.2 × 10−4 per year and in total increased 0.86% from 2002 to 2011 in alpine grassland, when most of the fPAR increments occurred in southeast and center of the Northern Tibetan Plateau, the alpine grassland tended to recover from degradation slightly. However, climatic factors have influenced the various alpine grassland vegetation fPAR over a period of 10 years; precipitation significantly affected the alpine meadow fPAR in the eastern region, whereas temperature considerably influenced the alpine desert steppe fPAR in the west region. These findings suggest that the regional heterogeneity in alpine grassland fPAR results from various environmental factors, except for vegetation characteristics, such as canopy structure and leaf area.

  6. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) has been shown to be of special importance during cancer invasion and metastasis. However, currently, tissue samples are needed for measurement of uPAR expression limiting the potential as a clinical routine. Therefore, non-invasive methods are...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  7. Magnetic activity and radial velocity filtering of young Suns: the weak-line T-Tauri stars Par 1379 and Par 2244

    Science.gov (United States)

    Hill, C. A.; Carmona, A.; Donati, J.-F.; Hussain, G. A. J.; Gregory, S. G.; Alencar, S. H. P.; Bouvier, J.; The Matysse Collaboration

    2017-12-01

    We report the results of our spectropolarimetric monitoring of the weak-line T-Tauri stars (wTTSs) Par 1379 and Par 2244, within the MaTYSSE (Magnetic Topologies of Young Stars and the Survival of close-in giant Exoplanets) programme. Both stars are of a similar mass (1.6 and 1.8 M⊙) and age (1.8 and 1.1 Myr), with Par 1379 hosting an evolved low-mass dusty circumstellar disc, and with Par 2244 showing evidence of a young debris disc. We detect profile distortions and Zeeman signatures in the unpolarized and circularly polarized lines for each star, and have modelled their rotational modulation using tomographic imaging, yielding brightness and magnetic maps. We find that Par 1379 harbours a weak (250 G), mostly poloidal field tilted 65° from the rotation axis. In contrast, Par 2244 hosts a stronger field (860 G) split 3:2 between poloidal and toroidal components, with most of the energy in higher order modes, and with the poloidal component tilted 45° from the rotation axis. Compared to the lower mass wTTSs, V819 Tau and V830 Tau, Par 2244 has a similar field strength, but is much more complex, whereas the much less complex field of Par 1379 is also much weaker than any other mapped wTTS. We find moderate surface differential rotation of 1.4× and 1.8× smaller than Solar, for Par 1379 and Par 2244, respectively. Using our tomographic maps to predict the activity-related radial velocity (RV) jitter, and filter it from the RV curves, we find RV residuals with dispersions of 0.017 and 0.086 km s-1 for Par 1379 and Par 2244, respectively. We find no evidence for close-in giant planets around either star, with 3σ upper limits of 0.56 and 3.54 MJup (at an orbital distance of 0.1 au).

  8. Comparative validation of the IPAQ and the 7-Day PAR among women diagnosed with breast cancer

    Directory of Open Access Journals (Sweden)

    Rock Cheryl L

    2006-03-01

    Full Text Available Abstract Background The criterion-related validity and measurement bias of the long form of the International Physical Activity Questionnaire (IPAQ was compared to the 7-Day Physical Activity Recall (PAR. Methods Participants were women who have been diagnosed with breast cancer and enrolled in the ongoing Women's Healthy Eating and Living Study. Women (N = 159, average age 57 years wore an accelerometer for one week and then completed the IPAQ or the PAR. Results The validity correlation of the PAR was significantly higher (p Conclusion The PAR was superior to the IPAQ in terms of validity, measurement bias, and screening statistics.

  9. Comparative validation of the IPAQ and the 7-Day PAR among women diagnosed with breast cancer

    Science.gov (United States)

    Johnson-Kozlow, Marilyn; Sallis, James F; Gilpin, Elizabeth A; Rock, Cheryl L; Pierce, John P

    2006-01-01

    Background The criterion-related validity and measurement bias of the long form of the International Physical Activity Questionnaire (IPAQ) was compared to the 7-Day Physical Activity Recall (PAR). Methods Participants were women who have been diagnosed with breast cancer and enrolled in the ongoing Women's Healthy Eating and Living Study. Women (N = 159, average age 57 years) wore an accelerometer for one week and then completed the IPAQ or the PAR. Results The validity correlation of the PAR was significantly higher (p ACSM physical activity guideline. Conclusion The PAR was superior to the IPAQ in terms of validity, measurement bias, and screening statistics. PMID:16579852

  10. Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome.

    Science.gov (United States)

    Roman, Kenny; Done, Joseph D; Schaeffer, Anthony J; Murphy, Stephen F; Thumbikat, Praveen

    2014-07-01

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) affects up to 15% of the male population and is characterized by pelvic pain. Mast cells are implicated in the murine experimental autoimmune prostatitis (EAP) model as key to chronic pelvic pain development. The mast cell mediator tryptase-β and its cognate receptor protease-activated receptor 2 (PAR2) are involved in mediating pain in other visceral disease models. Prostatic secretions and urines from CP/CPPS patients were examined for the presence of mast cell degranulation products. Tryptase-β and PAR2 expression were examined in murine EAP. Pelvic pain and inflammation were assessed in the presence or absence of PAR2 expression and upon PAR2 neutralization. Tryptase-β and carboxypeptidase A3 were elevated in CP/CPPS compared to healthy volunteers. Tryptase-β was capable of inducing pelvic pain and was increased in EAP along with its receptor PAR2. PAR2 was required for the development of chronic pelvic pain in EAP. PAR2 signaling in dorsal root ganglia led to extracellular signal-regulated kinase (ERK)1/2 phosphorylation and calcium influx. PAR2 neutralization using antibodies attenuated chronic pelvic pain in EAP. The tryptase-PAR2 axis is an important mediator of pelvic pain in EAP and may play a role in the pathogenesis of CP/CPPS. Copyright © 2014 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

  11. Aberrations in pseudoautosomal regions (PARs) found in infertile men with Y-chromosome microdeletions.

    Science.gov (United States)

    Jorgez, Carolina J; Weedin, John W; Sahin, Aysegul; Tannour-Louet, Mounia; Han, Shuo; Bournat, Juan C; Mielnik, Anna; Cheung, Sau Wai; Nangia, Ajay K; Schlegel, Peter N; Lipshultz, Larry I; Lamb, Dolores J

    2011-04-01

    The pseudoautosomal regions (PARs) of the Y-chromosome undergo meiotic recombination with the X-chromosome. PAR mutations are associated with infertility and mental and stature disorders. The aim of the study was to determine whether men with Y-chromosome microdeletions have structural defects in PARs. Eighty-seven infertile men with Y-chromosome microdeletions and 35 controls were evaluated for chromosomal rearrangements using commercial or custom (X- and Y-chromosome) array comparative genomic hybridization or by quantitative PCR of selected PAR genes. Multisoftware-defined chromosomal gains or losses were validated by quantitative PCR and FISH. Array comparative genomic hybridization confirmed the AZF deletions identified by multiplex PCR. All men with Y-chromosome microdeletions and an abnormal karyotype displayed PAR abnormalities, as did 10% of men with Y-chromosome microdeletions and a normal karyotype. None of the control subjects or infertile men without Y-chromosome microdeletions had PAR duplications or deletions. SHOX aberrations occurred in 14 men (nine gains and five losses); four were short in stature (95th percentile). In contrast, the height of 23 men with Y-chromosome microdeletions and normal PARs was average at 176.8 cm (50th percentile). Y-chromosome microdeletions can include PAR defects causing genomic disorders such as SHOX, which may be transmitted to offspring. Previously unrecognized PAR gains and losses in men with Y-chromosome microdeletions may have consequences for offspring.

  12. The urokinase receptor (uPAR) facilitates clearance of Borrelia burgdorferi.

    OpenAIRE

    Hovius, Joppe W. R; Bijlsma, Maarten F.; van der Windt, Gerritje J.W.; W Joost Wiersinga; Bastiaan J D Boukens; Jeroen Coumou; Anneke Oei; Regina de Beer; de Vos, Alex F; Veer, Cornelis van 't; van Dam, Alje P.; Penghua Wang; Erol Fikrig; Levi, Marcel M; Roelofs, Joris J. T. H.

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi bo...

  13. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  14. Stereotipi par dzimumu lomu sadali studentu ģimenē

    OpenAIRE

    Vilne, Līva

    2007-01-01

    Bakalaura darba tēma ir „Stereotipi par dzimumu lomu sadali studentu ģimenē”. Darbā tiek apskatītas dzimumu atšķirības, ģimenes skaidrojums un studentu ģimenes raksturojums, kā arī dzimumu lomu sadale studentu ģimenē un ar to saistītie stereotipi. Iegūtie dati liecina, ka studentu ģimenē valdošie sterotipi atbilst sabiedrībā pieņemtajiem tradicionālajiem stereotipiem. Jo dzimumu lomu sadale atbilst priekšstatiem – vīrietis nodrošina ģimeni finasiāli, bet sieviete ir mājsaimniece. Bakalaura da...

  15. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  16. Parálisis cerebral. Tratamiento ortopodológico

    OpenAIRE

    Querol Martínez, Esther; Crespo Martínez, Artur; Concustell Gonfaus, Josep; Sacristan Valero, Sergi; Concustell Fargas, Olga; Carrera Casanova, Ana

    2005-01-01

    Después de varios años de experiencia en la aplicación de las férulas estabilizadoras del sistema aquileocalcáneo plantar FESAP) en pacientes con parálisis cerebral, creemos que deberían ser el tratamiento ortopodológico de elección del pie equino en niños con miopatías y lesiones neurológlcas de la unidad motora, del sistema piramidal o extrapiramidal, tanto por su perfecta adaptación a la morfología de la extremidad inferior como por sus caracteristicas funcionales y sus acciones fisio1ógic...

  17. The polarity protein Par6 is coupled to the microtubule network during molluscan early embryogenesis

    Energy Technology Data Exchange (ETDEWEB)

    Homma, Taihei [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Shimizu, Miho [Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Kuroda, Reiko, E-mail: ckuroda@mail.ecc.u-tokyo.ac.jp [Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033 (Japan); Kuroda Chiromorphology Team, ERATO-SORST, JST, Komaba, Meguro-ku, Tokyo 153-8902 (Japan); Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902 (Japan)

    2011-01-07

    Research highlights: {yields} The cDNAs encoding Par6 and aPKC homologues were cloned from the snail Lymnaea stagnalis. {yields} L. stagnalis Par6 directly interacts with tubulin and microtubules and localizes to the microtubule cytoskeleton during the early embryogenesis. {yields} Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of body handedness. -- Abstract: Cell polarity, which directs the orientation of asymmetric cell division and segregation of fate determinants, is a fundamental feature of development and differentiation. Regulators of polarity have been extensively studied, and the critical importance of the Par (partitioning-defective) complex as the polarity machinery is now recognized in a wide range of eukaryotic systems. The Par polarity module is evolutionarily conserved, but its mechanism and cooperating factors vary among different systems. Here we describe the cloning and characterization of a pond snail Lymnaea stagnalis homologue of partitioning-defective 6 (Lspar6). The protein product LsPar6 shows high affinity for microtubules and localizes to the mitotic apparatus during embryonic cell division. In vitro assays revealed direct binding of LsPar6 to tubulin and microtubules, which is the first evidence of the direct interaction between the two proteins. The interaction is mediated by two distinct regions of LsPar6 both located in the N-terminal half. Atypical PKC, a functional partner of Par6, was also found to localize to the mitotic spindle. These results suggest that the L. stagnalis Par complex employs the microtubule network in cell polarity processes during the early embryogenesis. Identical sequence and localization of LsPar6 for the dextral and the sinistral snails exclude the possibility of the gene being the primary determinant of handedness.

  18. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  19. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  20. Correlation between Olea europaea and Parietaria judaica pollen counts and quantification of their major allergens Ole e 1 and Par j 1-Par j 2.

    Science.gov (United States)

    Moreno-Grau, Stella; Elvira-Rendueles, Belén; Moreno, José; García-Sánchez, Antonio; Vergara, Nuria; Asturias, Juan A; Arilla, M C; Ibarrola, Ignacio; Seoane-Camba, Juan A; Suárez-Cervera, Maria

    2006-06-01

    In patients with pollinosis, allergic symptoms are often correlated with the number of airborne pollen grains, although this correlation is not always close. The direct measurement of the concentration of aeroallergens has only recently been introduced and is an important advance in public health information systems. To compare specific quantification of aeroallergens Ole e 1 and Par j 1-Par j 2 Olea and Urticaceae pollen counts. The Hirst method sampler and the Burkard Cyclone sampler were used for pollen count and allergen quantification, respectively. The aerosol was extracted and quantified for Ole e 1 and Par j 1-Par j 2 content using enzyme-linked immunosorbent assay procedures. Day-to-day variations were observed in both the pollen count and the amount of allergens. Pollen counts and aeroallergen quantification were closely correlated with 99% significance (Olea/Ole e 1: R = 0.892, P < .001; Urticaceae/Par j 1-Par j 2: R = 0.734, P < .001). The technique for the sampling and quantification of aeroallergens presented in this article, based on enzyme-linked immunosorbent assay and applied to the protein extracts directly obtained from the bioaerosol, represents an important advance in the epidemiologic study of allergic respiratory diseases.

  1. A study of internal contamination levels resulting from {sup 90}Sr and {sup 137}Cs environmental pollution. The influence of different factors; Etude des niveaux de contamination interne resultant d'une pollution de l'environnement par le {sup 90}Sr et le {sup 137}Cs influence des differents parametres

    Energy Technology Data Exchange (ETDEWEB)

    Garnier, A. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1970-07-01

    This study includes two parts. The purpose of the former one is to try and evaluate the amounts of {sup 90}Sr and {sup 137}Cs dietary intakes as a function of age with a view to assessing internal exposure doses and estimating the critical age, and to study the relative significance of the several factors it depends on. The data used are both the results of dietary surveys made in 11 districts of the European community from which the evolution of the consumed amounts of 13 groups of foodstuffs, as a function of age was derived, and the mean factors of contamination pathways. The variability of some factors is very large and an attempt is made to assess their significance on the whole contamination; also, the influence of the various diets has been emphasized. The purpose of the second part is to assess, doses as a function of age in the case of protracted exposure on the basis of the aforesaid results and radiobiological factors derived from bibliographic states of the arts. An assessment is made of body burdens and mean doses (either to the skeleton or the whole body according to the radionuclides) originating either from a direct unitary exposure or from situations implying both modes of exposure. As assumed only the diets vary with the districts, thus the results reflect their significance which should be corrected, for a more accurate assessment of the dose variability, by the significance of human and transfer factors. (author) [French] Cette etude comprend deux parties. L'objet de la premiere partie est a la fois un essai d'evaluation en fonction de l'age des quantites de strontium 90 et de cesium 137 ingerees avec les aliments dans la perspective d'une application a l'estimation des doses d'irradiation interne et a la recherche de l'age critique, et une etude de l'influence relative des divers parametres dont elle depend. Les donnees utilisees sont, d'une part, les resultats des enquetes alimentaires faites en

  2. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...

  3. Contamination des eaux souterraines par le lixiviat des décharges ...

    African Journals Online (AJOL)

    La percolation du lixiviat en provenance des dechets des decharges constitue une source de pollution des ressources en eau souterraine par infiltration, constituant ... un modele type de deterioration des ressources en eaux par un effet de contamination du lixiviat en provenance de la decharge et des pratiques agricoles.

  4. 177-lu labeled peptide for site-specific uPAR-targeting

    DEFF Research Database (Denmark)

    2015-01-01

    There is provided a 177-Lu labelled peptide for site-specific targeting of the Urokinase Plasminogen Activator Receptor (uPAR) thereby enabling treatment of a cancer disease associated with high uPAR expression; e.g. treatment of colorectal cancer by administering to a patient an effective amount...... of the 177-Lu labelled peptide....

  5. Effect of pre-drying and par-frying conditions on the crispness of French fries

    NARCIS (Netherlands)

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all

  6. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  7. Soluble urokinase plasminogen activator receptor (suPAR) in acute care

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Ladelund, Steen; Haupt, Thomas Huneck

    2016-01-01

    OBJECTIVE: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory biomarker associated with presence and progression of disease and with increased risk of mortality. We aimed to evaluate the unspecific biomarker suPAR as a prognostic marker in patients admitted to acute care...

  8. Study of the artificial radioactivity of the marine medium using gamma spectrometry (1962-1966); Etude de la radioactivite artificielle du milieu marin par spectrometrie gamma (1962-1966)

    Energy Technology Data Exchange (ETDEWEB)

    Chesselet, R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-07-01

    atmospherique entre 1962 et 1964 et les incidences de cette retombee dans les eaux marines superficielles. Considerant les radioelements etudies comme des 'traceurs' dans le milieu marin, divers processus physiques, chimiques ou biologiques ont ete etudies par spectrometrie gamma a haute sensibilite. Le passage en phase soluble dans l'eau de mer d'une fraction importante (environ 50 pour cent) de l'activite liee aux poussieres radioactives, phenomene qui n'etait pas previsible pour les radioelements etudies, gouverne les processus d'accumulation dans la biomasse planctonique et la diffusion vers les eaux plus profondes. Par ailleurs, une methode de spectrometrie 'in situ' permettant de mesurer directement dans la mer de tres faibles concentrations en certains radionuclides emetteurs gamma est decrite. L'application de cette methode a permis de nombreuses observations dans les eaux de surface de la Mediterranee occidentale et du Golfe de Gascogne. On montre quo la profondeur de melange est etroitement liee a celle de la thermocline. Un processus d'accumulation au niveau de celle-ci est constate. Les coefficients de diffusion sont voisins du coefficient de diffusion thermique turbulente. L'existence de compartiments qui subsistent pendant plusieurs mois dans la masse des eaux de surface du Golfe de Gascogne est mise en evidence. Grace aux bilans effectues, une etude comparative montre que le taux de retombees radioactives sur les surfaces maritimes est toujours deux a trois fois superieur a celui sur les regions continentales voisines. Diverses explications de ce phenomene sont discutees. (auteur)

  9. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  10. Activation of protease-activated receptors (PARs)-1 and -2 promotes alpha-smooth muscle actin expression and release of cytokines from human lung fibroblasts.

    Science.gov (United States)

    Asokananthan, Nithiananthan; Lan, Rommel S; Graham, Peter T; Bakker, Anthony J; Tokanović, Ana; Stewart, Geoffrey A

    2015-02-01

    Previous studies have shown that protease-activated receptors (PARs) play an important role in various physiological processes. In the present investigation, we determined the expression of PARs on human lung fibroblasts (HLF-1) and whether they were involved in cellular differentiation and pro-inflammatory cytokine and prostaglandin (PGE2) secretion. PAR-1, PAR-2, PAR-3, and PAR-4 were detected in fibroblasts using RT-PCR, immunocytochemistry, and flow cytometry. Increased expression of PAR-4, but not other PARs, was observed in fibroblasts stimulated with phorbol myristate acetate. The archetypical activators of PARs, namely, thrombin and trypsin, as well as PAR-1 and PAR-2 agonist peptides, stimulated transient increases in intracellular Ca(2+), and promoted increased α-smooth muscle actin expression. The proteolytic and peptidic PAR activators also stimulated the release of IL-6 and IL-8, as well as PGE2, with a rank order of potency of PAR-1 > PAR-2. The combined stimulation of PAR-1 and PAR-2 resulted in an additive release of both IL-6 and IL-8. In contrast, PAR-3 and PAR-4 agonist peptides, as well as all the PAR control peptides examined, were inactive. These results suggest an important role for PARs associated with fibroblasts in the modulation of inflammation and remodeling in the airway. © 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

  11. Attic cholesteatoma with closure of the entrance to pars flaccida retraction pocket.

    Science.gov (United States)

    Matsuzawa, Shingo; Iino, Yukiko; Yamamoto, Daiki; Hasegawa, Masayo; Hara, Mariko; Shinnabe, Akihiro; Kanazawa, Hiromi; Yoshida, Naohiro

    2017-12-01

    We report three patients with pars flaccida-type cholesteatoma (attic cholesteatoma) with closure of the entrance to the cholesteatoma at the time of surgery. These patients were diagnosed with attic cholesteatoma requiring surgery on the basis of abnormal findings of the pars flaccida, audiometry, and temporal bone computed tomography during the clinical course. Intraoperatively, cholesteatoma matrix and granulation tissue were observed behind the intact pars flaccida epithelium, which suggested that the entrance had apparently closed and the continuity with the cholesteatoma matrix disappeared after resolution of inflammation at the pars flaccida. In such patients, a normal pars flaccida may cause cholesteatoma to be initially overlooked, or misdiagnosed as congenital cholesteatoma. The diagnosis should be carefully made on the basis of the clinical course and the results of various examinations. Copyright © 2016 Elsevier B.V. All rights reserved.

  12. Compression Myelopathy due to Proliferative Changes around C2 Pars Defects without Instability.

    Science.gov (United States)

    Kimura, Tetsuya; Sakai, Toshinori; Tezuka, Fumitake; Abe, Mitsunobu; Yamashita, Kazuta; Takata, Yoichiro; Higashino, Kosaku; Sairyo, Koichi

    2016-06-01

    We report a case with compression myelopathy due to proliferative changes around the C2 pars defects without instability. A 69-year-old man presented with progressive clumsy hands and spastic gait. Plain radiographs showed bilateral spondylolysis (pars defects) at C2 and fusion between C2 and C3 spinous processes. Dynamic views revealed mobility through the pars defects, but there was no apparent instability. Computed tomography showed proliferative changes at the pars defects, which protruded into spinal canal. On magnetic resonance imaging, the spinal cord was compressed and intramedullary high signal change was found. A diagnosis of compression myelopathy due to proliferative changes around the C2 pars defects was made. We performed posterior decompression. Postoperatively, symptoms have been alleviated and images revealed sufficient decompression and no apparent instability. In patients with the cervical spondylolysis, myelopathy caused by instability or slippage have been periodically reported. The present case involving C2 spondylolysis is extremely rare.

  13. A study by internal friction of defects produced in iron and nickel irradiated at very low temperatures; Etude au moyen du frottement interne des defauts crees par irradiation a tres basse temperature dans le fer et le nickel

    Energy Technology Data Exchange (ETDEWEB)

    Keating-Hart, G. de [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    This work represents a contribution to the study of point defects in metals. After a brief review of the theory of internal friction we will discuss some technical innovations aimed at increasing the flexibility of the apparatus at our disposal. These innovations have allowed us to extend our range of measurements down to 20 deg. K. We will then discuss our experimental results. Firstly, we describe preliminary experiments on electron irradiated iron and the evidence for a laminar structure. Secondly, we present and account of the first measurements on nickel after neutron irradiation at 27 deg. K. We will compare the results with those obtained by other methods in this laboratory. Essentially we have observed transitory peaks at low temperature due to close Frenkel pairs and we have noticed the absence of a peak which would correspond to the magnetic after effect band of stage I{sub E}. An attempt is made to explain the disappearance of the observed peaks upon the application of an internal saturating magnetic field. (author) [French] Ce memoire constitue une contribution a l'etude des defauts ponctuels dans les metaux. Apres un bref apercu theorique sur le frottement interne, nous presenterons quelques realisations techniques destinees a accroitre les possibilites des instruments qui nous ont ete confies. Ces dernieres nous ont permis d'etendre la gamme des mesures jusqu'a 20 deg. K. Nous parlerons ensuite de nos resultats experimentaux. En premier lieu, ceux obtenus au cours de premieres experiences, sur le fer irradie aux electrons mettent en evidence des structures de laminage. En second lieu, nous exposerons les premieres mesures realisees sur du nickel irradie aux neutrons; nous comparerons ces resultats avec ceux obtenus par d'autres moyens experimentaux dans le laboratoire. Nous avons observe essentiellement des pics fugitifs a basse temperature dus aux paires proches de Frenckel et nous avons constate l'absence d'un pic

  14. Accuracy and efficacy of fluoroscopy-guided pars interarticularis injections on immediate and short-term pain relief.

    Science.gov (United States)

    Kershen, L Michael; Nacey, Nicholas C; Patrie, James T; Fox, Michael G

    2016-10-01

    To determine the accuracy and short-term efficacy of fluoroscopy-guided steroid/anesthetic injections for symptomatic pars interarticularis (pars) defects. Following IRB approval, all fluoroscopically guided pars injections from a single institution (6/2010 to 3/2016) were retrospectively and independently reviewed by two MSK radiologists. The radiologists evaluated the fluoroscopic images to determine if all of the pars injections associated with each procedure were intra-pars (n = 57 procedures; 106 pars injections), peri-pars (n = 3 procedures; three pars injected), or a combination of intra-pars and peri-pars (n = 6 procedures; 12 pars injected). The patients were asked their pain score (graded on a scale of 0-10) pre-injection, 5-10 min and 1-week post-injection. Age, gender, and fluoroscopic times were recorded. Statistical analysis was performed on the all intra-pars injections only. Exact inter-reader agreement was present in 92 % (112/121) of the injections, with 57 of the procedures (106 pars injections) performed on 41 patients (mean age 36; 18 M, 23 F) all intra-pars. The mean pre-injection and 5-10 min post-injection reduction in pain for the all intra-pars injections was -3.0 units (95 % CI: [-3.9, -2.1] units; p pars) reduction in pain of -0.7 units (95 % CI [-1.5, 0.0]; p = 0.06). The geometric mean fluoroscopic time per pars injected was 42 s. Over 92 % of fluoroscopically guided injections for symptomatic spondylolysis are technically successful with minimum fluoroscopic time, resulting in statistically significant pain reduction immediately post-injection and a trend in pain reduction 1-week post-injection.

  15. Par-1b is required for morphogenesis and differentiation of myoepithelial cells during salivary gland development.

    Science.gov (United States)

    Gervais, Elise M; Sequeira, Sharon J; Wang, Weihao; Abraham, Stanley; Kim, Janice H; Leonard, Daniel; DeSantis, Kara A; Larsen, Melinda

    2016-10-01

    The salivary epithelium initiates as a solid mass of epithelial cells that are organized into a primary bud that undergoes morphogenesis and differentiation to yield bilayered acini consisting of interior secretory acinar cells that are surrounded by contractile myoepithelial cells in mature salivary glands. How the primary bud transitions into acini has not been previously documented. We document here that the outer epithelial cells subsequently undergo a vertical compression as they express smooth muscle α-actin and differentiate into myoepithelial cells. The outermost layer of polarized epithelial cells assemble and organize the basal deposition of basement membrane, which requires basal positioning of the polarity protein, Par-1b. Whether Par-1b is required for the vertical compression and differentiation of the myoepithelial cells is unknown. Following manipulation of Par-1b in salivary gland organ explants, Par-1b-inhibited explants showed both a reduced vertical compression of differentiating myoepithelial cells and reduced levels of smooth muscle α-actin. Rac1 knockdown and inhibition of Rac GTPase function also inhibited branching morphogenesis. Since Rac regulates cellular morphology, we investigated a contribution for Rac in myoepithelial cell differentiation. Inhibition of Rac GTPase activity showed a similar reduction in vertical compression and smooth muscle α-actin levels while decreasing the levels of Par-1b protein and altering its basal localization in the outer cells. Inhibition of ROCK, which is required for basal positioning of Par-1b, resulted in mislocalization of Par-1b and loss of vertical cellular compression, but did not significantly alter levels of smooth muscle α-actin in these cells. Overexpression of Par-1b in the presence of Rac inhibition restored basement membrane protein levels and localization. Our results indicate that the basal localization of Par-1b in the outer epithelial cells is required for myoepithelial cell

  16. Inhibition of uPAR-TGFβ crosstalk blocks MSC-dependent EMT in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Biagioni, Alessio; Bianchini, Francesca; Peppicelli, Silvia; Chillà, Anastasia; Margheri, Francesca; Luciani, Cristina; Pimpinelli, Nicola; Del Rosso, Mario; Calorini, Lido; Fibbi, Gabriella

    2015-07-01

    The capacity of cancer cells to undergo epithelial-to-mesenchymal transition (EMT) is now considered a hallmark of tumor progression, and it is known that interactions between cancer cells and mesenchymal stem cells (MSCs) of tumor microenvironment may promote this program. Herein, we demonstrate that MSC-conditioned medium (MSC-CM) is a potent inducer of EMT in melanoma cells. The EMT profile acquired by MSC-CM-exposed melanoma cells is characterized by an enhanced level of mesenchymal markers, including TGFβ/TGFβ-receptors system upregulation, by increased invasiveness and uPAR expression, and in vivo tumor growth. Silencing TGFβ in MSC is found to abrogate ability of MSC to promote EMT characteristics in melanoma cells, together with uPAR expression, and this finding is strengthened using an antagonist peptide of TGFβRIII, the so-called P17. Finally, we demonstrate that the uPAR antisense oligonucleotide (uPAR aODN) may inhibit EMT of melanoma cells either stimulated by exogenous TGFβ or MSC-CM. Thus, uPAR upregulation in melanoma cells exposed to MSC-medium drives TGFβ-mediated EMT. On the whole, TGFβ/uPAR dangerous liaison in cancer cell/MSC interactions may disclose a new strategy to abrogate melanoma progression. Mesenchymal stem cell (MSC)-conditioned medium induces EMT-like profile in melanoma. MSC-derived TGFβ promotes uPAR and TGFβ/TGFβ-receptor upregulation in melanoma. TGFβ gene silencing in MSCs downregulates uPAR expression and EMT in melanoma. uPAR downregulation prevents MSC-induced EMT-like profile in melanoma cells. Inhibition of the dangerous TGFβ/uPAR relationship might abrogate melanoma progression.

  17. Approches pour la reduction de l'impact de defaut dans le transport d'energie du parc eolien offshore via VSC-HVDC =

    Science.gov (United States)

    Benadja, Mounir

    Dans ce travail est presente un systeme de generation d'energie d'un parc eolien offshore et un systeme de transport utilisant les stations VSC-HVDC connectees au reseau principal AC onshore. Trois configurations ont ete etudiees, modelisees et validees par simulation. Dans chacune des configurations, des contributions ameliorant les cotes techniques et economiques sont decrites ci-dessous : La premiere contribution concerne un nouvel algorithme MPPT (Maximum Power Point Tracking) utilise pour l'extraction de la puissance maximale disponible dans les eoliennes des parcs offshores. Cette technique d'extraction du MPPT ameliore le rendement energetique de la chaine de conversion des energies renouvelables notamment l'energie eolienne a petite et a grande echelles (parc eolien offshore) qui constitue un probleme pour les constructeurs qui se trouvent confrontes a developper des dispositifs MPPT simples, moins couteux, robustes, fiables et capable d'obtenir un rendement energetique maximal. La deuxieme contribution concerne la reduction de la taille, du cout et de l'impact des defauts electriques (AC et DC) dans le systeme construit pour transporter l'energie d'un parc eolien offshore (OWF) vers le reseau principal AC onshore via deux stations 3L-NPC VSCHVDC. La solution developpee utilise des observateurs non-lineaires bases sur le filtre de Kalman etendu (EKF). Ce filtre permet d'estimer la vitesse de rotation et la position du rotor de chacune des generatrices du parc eolien offshore et de la tension du bus DC de l'onduleur DC-AC offshore et des deux stations 3L-NPC-VSC-HVDC (offshore et onshore). De plus, ce developpement du filtre de Kalman etendu a permis de reduire l'impact des defauts AC et DC. Deux commandes ont ete utilisees, l'une (commande indirect dans le plan abc) avec EKF integre destinee pour controler le convertisseur DC-AC offshore et l'autre (commande d-q) avec EKF integre pour controler les convertisseurs des deux stations AC-DC et DC-AC tout en

  18. Desalting of sea water by a wall-less evaporation process; Dessalement de l'eau de mer par un procede d'evaporation sans paroi

    Energy Technology Data Exchange (ETDEWEB)

    Kassel, C.; Sachine, P.; Vuillemey, R. [Commissariat a l' Energie Atomique, Centre d' Etudes Nucleaires de Saclay, 91 - Gif-sur-Yvette (France)

    1966-06-01

    The need for fresh water supplies in many parts of the globe has given a great impetus to the study of the desalting of sea-water. Research into this problem has been very varied. Although it is possible in the more-or-less near future that methods based on freezing may be developed, only evaporation methods have industrial applications at the present time. Amongst the many techniques using this method, the most favorably placed installations from the technical and economic points of view are those based on multiple effects and wall-less heat transfer. We have defined the characteristics of a wall-less evaporation process using the various factors involved in this evaporation: energy source, corrosion, furring, heat transfer, maximum temperature, etc... The unit considered in this work has a daily output of 100,000 m{sup 3}, and makes use of the multi-stage technique with an organic heat-carrier. The maximum temperature of the first stage is 150 deg C and the evaporation factor is 0.4. After the description of the process and, the calculation of the equipment, an economic estimate is given of the cost-price : 1.49 F/m{sup 3}. It is likely that more detailed study of the process (technique, equipment and energy consumed) should make it possible to obtain a significant improvement in the process and to reduce the price to 1 F/m{sup 3}. (authors) [French] Le probleme de l 'approvisionnement en eau de nombreuses regions du globe a mis a 1'ordre du jour le dessalement de l'eau de mer. Des recherches sur cette question ont ete faites dans de multiples directions. Si dans un avenir plus ou moins proche les procedes par congelation peuvent se developper, actuellement seules les methodes d'evaporation ont des applications industrielles. Parmi les nombreuses techniques qui visent a mettre en oeuvre ce principe, les installations a multiples effets et transfert de chaleur sans paroi semblent les mieux placees du point de vue technique et economique. A

  19. Facteurs de risque de mortalité par tuberculose pulmonaire

    Science.gov (United States)

    Janah, Hicham; Souhi, Hicham; Kouismi, Hatim; Mark, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    La tuberculose est une maladie infectieuse transmissible provoquée par myco-bacterium tuberculosis (bacille de Koch ou BK). Elle représente, selon les estimations del'Organisation Mondiale de la Santé (OMS), l'une des pathologies infectieuses causant le plus de décès au niveau mondial avec plus de 1 million de décès par an. Pour déterminer les facteurs de risque de mortalité au cours de la tuberculose pulmonaire à microscopie positive nous avons mené une étude rétrospective portant sur tous les cas de tuberculose pulmonaire à microscopie positive et qui étaient décédés au cours de leur hospitalisation. Cette étude a colligé 1803 cas de tuberculose sur une période de 2 ans et demi dont 46 sont décédés. La prévalence de décès est de 2,55%. La population se répartit en 32 hommes et 14 femmes. L’âge moyen était de 53ans ± 17 ans. Le tabagisme était retrouvé chez la moitié des cas. Une comorbidité était retrouvée dans 43%, avec 17% de diabète. Le délai de diagnostic avait une médiane de 60 jours avec percentile (30j; 105j). La symptomatologie clinique était dominée par la toux, la dyspnée et les expectorations soit respectivement: 97,8%, 69,6% et 67,4% des cas. Sur le plan radiologique les lésions étaient diffuses et bilatérales dans 76,1% des cas. Tous les patients étaient mis sous SRHZ. 11% avaient présenté une toxicité aux antibacillaires (de type hépatiques dans 3 cas et neurologiques dans 2 cas). Le délai médian de décès était de 8,5 jours (5j; 17j). Les causes de décès retrouvées étaient: Une hépatite fulminante (3 cas), une décompensation acido-cétosique (3 cas), un SDRA (2 cas), des hémoptysies foudroyantes (2 cas), et respectivement un cas secondaire à une décompensation de BPCO, une décompensation cardiaque, une hypoglycémie et un tableau d'anasarque. Cette étude suggère que le terrain, le retard diagnostique et les effets secondaires du traitement sont les principaux facteurs de risque de

  20. RepB proteins of the multipartite Rhizobium leguminosarum bv. trifolii genome discriminate between centromere-like parS sequences for plasmid segregational stability.

    Science.gov (United States)

    Koper, Piotr; Żebracki, Kamil; Marczak, Małgorzata; Skorupska, Anna; Mazur, Andrzej

    2016-11-01

    The plasmids of the Rhizobiaceae family members and other Alphaproteobacteria are usually large, low copy-number and contain all elements necessary for active segregation and replication located in one operon comprising repABC genes. The genome of Rhizobium leguminosarum bv. trifolii TA1 (RtTA1) consists of a chromosome and four plasmids (pRleTA1a-d) with repABC operons. In this work, centromere-binding RepB proteins of four RtTA1 plasmids were studied. Stability assays of the truncated derivatives of repABC cassettes demonstrated that RepA, RepB proteins and parS-like elements constituted plasmid partitioning systems, while RepC were sufficient for their replication. Individual RepB proteins bound specifically to centromere-like parS elements of the parental plasmids, which was crucial step toward the proper segregation of plasmids into daughter cells. RtTA1 RepB proteins formed dimers and oligomers in the solution. The C-terminal part of RepB was responsible for dimerization, while the domain engaged in parS binding was located in the middle of the protein. It was concluded that the specific interaction between individual RepB proteins and their target sequences together with the substantial diversity of the Rep proteins and parS originating from different plasmids strongly contributed to the coexistence of several plasmids equipped with similar repABC cassettes in the multipartite bacterial genome. © 2016 John Wiley & Sons Ltd.

  1. Effets des electrons secondaires sur l'ADN

    Science.gov (United States)

    Boudaiffa, Badia

    Les interactions des electrons de basse energie (EBE) representent un element important en sciences des radiations, particulierement, les sequences se produisant immediatement apres l'interaction de la radiation ionisante avec le milieu biologique. Il est bien connu que lorsque ces radiations deposent leur energie dans la cellule, elles produisent un grand nombre d'electrons secondaires (4 x 104/MeV), qui sont crees le long de la trace avec des energies cinetiques initiales bien inferieures a 20 eV. Cependant, il n'y a jamais eu de mesures directes demontrant l'interaction de ces electrons de tres basse energie avec l'ADN, du principalement aux difficultes experimentales imposees par la complexite du milieu biologique. Dans notre laboratoire, les dernieres annees ont ete consacrees a l'etude des phenomenes fondamentaux induits par impact des EBE sur differentes molecules simples (e.g., N2, CO, O2, H2O, NO, C2H 4, C6H6, C2H12) et quelques molecules complexes dans leur phase solide. D'autres travaux effectues recemment sur des bases de l'ADN et des oligonucleotides ont montre que les EBE produisent des bris moleculaires sur les biomolecules. Ces travaux nous ont permis d'elaborer des techniques pour mettre en evidence et comprendre les interactions fondamentales des EBE avec des molecules d'interet biologique, afin d'atteindre notre objectif majeur d'etudier l'effet direct de ces particules sur la molecule d'ADN. Les techniques de sciences des surfaces developpees et utilisees dans les etudes precitees peuvent etre etendues et combinees avec des methodes classiques de biologie pour etudier les dommages de l'ADN induits par l'impact des EBE. Nos experiences ont montre l'efficacite des electrons de 3--20 eV a induire des coupures simple et double brins dans l'ADN. Pour des energies inferieures a 15 eV, ces coupures sont induites par la localisation temporaire d'un electron sur une unite moleculaire de l'ADN, ce qui engendre la formation d'un ion negatif transitoire

  2. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  3. Envenimation mortelle par morsure de serpent chez une femme enceinte

    Directory of Open Access Journals (Sweden)

    Abdelkarim Shimi

    2011-02-01

    Full Text Available En Afrique, la prise en charge des envenimations vipérines demeure un problème majeur de santé publique avec un taux de mortalité qui reste élevé.La survenue d’une envenimation vipérine au cours de la grossesse est un événement rare, et grave du fait des conséquences maternelles et fatales qui en découlent. Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l’évolution a été marquée par l’installation d’un œdème cervico-facial nécessitant une trachéotomie en urgence, et une mort fatale in utero avec troubles de l’hémostase responsable du décès maternel dans un tableau de choc hémorragique.

  4. Le Web pour enseigner par projets et favoriser la collaboration

    Directory of Open Access Journals (Sweden)

    Sylvie Ratté

    2004-01-01

    Full Text Available L’utilisation du Web présentée dans cet article vient appuyer une démarche pédagogique fondée sur le partage des savoirs. Dans le contexte d’une simulation industrielle, les étudiants d’un cours de programmation avancée doivent apprendre à partager leur expertise, à communiquer clairement leurs questions, à décrire des problèmes et à faire face à des retournements inattendus. Le Web devient un espace de collaboration pour diffuser les requêtes d’un client fictif, les directives, les travaux préliminaires et les ententes. Les résultats obtenus tendent à suggérer que cette approche globale force l’étudiant à mieux planifier, l’invite à mieux formuler et décrire les problèmes, augmente le niveau de collaboration et facilite la production d’analogies. Un système facilitant la logistique entourant la revue par les pairs (récupération des travaux, construction d’une grille d’évaluation et diffusion des résultats est également présenté.

  5. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Liliana Semenas

    1999-08-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  6. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  7. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  8. ANALYSIS OF PARS PLANA VITRECTOMY INCISIONS USING LIVE BACTERIA.

    Science.gov (United States)

    Cohen, Michael N; Houston, Samuel K; Roberts, Amity L; Eagle, Ralph C; Gupta, Omesh P

    2017-06-01

    To analyze small gauge pars plana vitrectomy sclerotomies using live bacteria transformed with green fluorescent protein (GFP). Twenty-eight human cadaver eyes were specially harvested for this study. Small gauge vitrectomy was performed on each eye and the wounds were closed with various techniques (sutured, sutureless, and cauterization). Live Staphylococcus epidermidis that has been transformed with a green fluorescent protein was applied to the overlying conjunctival surface. Analysis of all vitreous samples was analyzed with confocal laser microscopy to identify the presence of bacteria. All wounds were analyzed histopathologically. A high concentration of bacteria was noted in 2 of 3 eyes in the sutureless, 23-G perpendicular incision group postinoculation. There were no bacteria detected in any postvitrectomy sample that were closed with cautery or a beveled incision. No bacteria were found in postvitrectomy samples of sutureless 27-G perpendicular incisions and sutureless 27-G beveled incisions. Finally, there were no bacteria detected in both eyes with 23-G perpendicular incisions that had a partial air-fill. Live bacteria can be effectively used to analyze wound integrity. Closing sclerotomy sites with cautery proved effective in a model using fresh, human cadaver eyes. 27-G perpendicular incisions may be just as competent as 27-G beveled incisions.

  9. Characterization of a dodecapeptide containing a dominant epitope of Par j 1 and Par o 1, the major allergens of P. judaica and P. officinalis pollen.

    Science.gov (United States)

    Menna, T; Cassese, G; Di Modugno, F; Chersi, A; Buono, C; Ruffilli, A

    1999-10-01

    The pollen of Parietaria, a weed of the Urticaceae family, is a major cause of respiratory allergy in Europe, where the most common species are P. judaica and P. officinalis. Previously, we reported that a beta-galactosidase fusion protein (6a-BG) expressing a 26-bp cDNA fragment (6a cDNA) contained a dominant IgE-binding epitope (6a epitope) of the major allergens Par o 1 and Par j 1. The present study aimed to define the amino-acid sequence containing the 6a epitope. We analyzed the reactivity of anti-Par o 1 antibodies affinity purified from allergic patient sera with: 1) a panel of synthetic peptides deduced from the 6a nucleotide sequence using different reading frames 2) glutathione S-transferase (GST) fusion proteins containing selected peptides. The peptide NSARARADSCRI (p102) specifically bound anti-Par o 1 antibodies affinity purified from allergic patient sera or from rabbit anti-Par o 1 antiserum (ELISA). The related peptide NSARAGTSSCRI (p101) reacted to human but not to rabbit, anti-Par o 1 antibodies. GST fusion proteins containing p101 (GST 3.5) or p102 (GST 3.2) extensively inhibited the binding between Par o 1 and IgE or IgG antibodies from an allergic patient serum pool according to a dose-response curve. Percent inhibition of IgE antibodies binding obtained by absorbing a solution (50 microl) of affinity-purified antibodies with 5 microg of GST 3.2 or with 1.2 mg of GST 3.5 was 69% and 66%, respectively. In conclusion, the results of the present study indicate that the amino-acid sequences NSARARADSCRI (p102) and NSARAGTSSCRI (p101) contain the dominant epitope of Par o 1 and Par j 1 for human IgE and IgG antibodies indicated as 6a epitope. Moreover, the study shows that the epitope is conserved in recombinant molecules containing these peptides, irrespective of the fused polypeptide (beta-galactosidase or GST). The knowledge of the amino-acid sequence of this dominant epitope is important in therapeutic approaches to the development of allergen

  10. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  11. Pars plana Ahmed valve and vitrectomy in patients with glaucoma associated with posterior segment disease.

    Science.gov (United States)

    Wallsh, Josh O; Gallemore, Ron P; Taban, Mehran; Hu, Charles; Sharareh, Behnam

    2013-01-01

    To assess the safety and efficacy of a modified technique for pars plana placement of the Ahmed valve in combination with pars plana vitrectomy in the treatment of glaucoma associated with posterior segment disease. Thirty-nine eyes with glaucoma associated with posterior segment disease underwent pars plana vitrectomy combined with Ahmed valve placement. All valves were placed in the pars plana using a modified technique, without the pars plana clip, and using a scleral patch graft. The 24 eyes diagnosed with neovascular glaucoma had an improvement in intraocular pressure from 37.6 mmHg to 13.8 mmHg and best-corrected visual acuity from 2.13 logarithm of minimum angle of resolution to 1.40 logarithm of minimum angle of resolution. Fifteen eyes diagnosed with steroid-induced glaucoma had an improvement in intraocular pressure from 27.9 mmHg to 14.1 mmHg and best-corrected visual acuity from 1.38 logarithm of minimum angle of resolution to 1.13 logarithm of minimum angle of resolution. Complications included four cases of cystic bleb formation and one case of choroidal detachment and explantation for hypotony. Ahmed valve placement through the pars plana during vitrectomy is an effective option for managing complex cases of glaucoma without the use of the pars plana clip.

  12. Lumbar lordosis and pars interarticularis fractures: a case-control study.

    Science.gov (United States)

    Bugg, William G; Lewis, Mark; Juette, Arne; Cahir, John G; Toms, Andoni P

    2012-07-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9° (SD = 6.5°) in the pars interarticularis fracture group, and 30.1° (SD = 6.4°) in the control group. The difference between the two groups was significant (mean difference 6.8°, Student's t test: P pars defects. The difference in the means of 14.2° was statistically significantly different (P pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis.

  13. The pars intermedia: an anatomic basis for a coordinated vascular response to female genital arousal.

    Science.gov (United States)

    Shih, Cheryl; Cold, Christopher J; Yang, Claire C

    2013-06-01

    The pars intermedia is an area of the vulva that has been inconsistently described in the literature. We conducted anatomic studies to better describe the tissues and vascular structures of the pars intermedia and proposed a functional rationale of the pars intermedia in the female sexual response. Nine cadaveric vulvectomy specimens were used. Each was serially sectioned and stained with hematoxylin and eosin and Masson's trichrome. Histologic ultrastructural description of the pars intermedia. The pars intermedia contains veins traveling longitudinally in the angle of the clitoris, supported by collagen-rich stromal tissues. These veins drain the different vascular compartments of the vulva, including the clitoris, the bulbs, and labia minora; also, the interconnecting veins link the different vascular compartments. The pars intermedia is not composed of erectile tissue, distinguishing it from the erectile tissues of the corpora cavernosa of the clitoris as well as the corpus spongiosum of the clitoral (vestibular) bulbs. The venous communications of the pars intermedia, linking the erectile tissues with the other vascular compartments of the vulva, appear to provide the anatomic basis for a coordinated vascular response during female sexual arousal. © 2012 International Society for Sexual Medicine.

  14. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes.

    Science.gov (United States)

    Hunding, Axel; Ebersbach, Gitte; Gerdes, Kenn

    2003-05-23

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about 20 minutes. A model is discussed which is based on cooperative non-specific binding of ParA to the nucleoid, and local ParB initiated generation of ParA oligomer degradation products, which act autocatalytically on the degradation reaction. The model yields self-initiated spontaneous pattern formation, based on Turing's mechanism, and these patterns are destroyed by the degradation products, only to initiate a new pattern at the opposite nucleoid region. A recurrent wave thus emerges. This may be a particular example of a more general class of pattern forming mechanisms, based on protein oligomerization upon a template (membranes, DNA a.o.) with resulting enhanced NTPase function in the oligomer state, which may bring the oligomer into an unstable internal state. An effector initializes destabilization of the oligomer to yield degradation products, which act as seeds for further degradation in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes.

  15. Proteinase-activated receptors (PARs) – focus on receptor-receptor-interactions and their physiological and pathophysiological impact

    Science.gov (United States)

    2013-01-01

    Proteinase-activated receptors (PARs) are a subfamily of G protein-coupled receptors (GPCRs) with four members, PAR1, PAR2, PAR3 and PAR4, playing critical functions in hemostasis, thrombosis, embryonic development, wound healing, inflammation and cancer progression. PARs are characterized by a unique activation mechanism involving receptor cleavage by different proteinases at specific sites within the extracellular amino-terminus and the exposure of amino-terminal “tethered ligand“ domains that bind to and activate the cleaved receptors. After activation, the PAR family members are able to stimulate complex intracellular signalling networks via classical G protein-mediated pathways and beta-arrestin signalling. In addition, different receptor crosstalk mechanisms critically contribute to a high diversity of PAR signal transduction and receptor-trafficking processes that result in multiple physiological effects. In this review, we summarize current information about PAR-initiated physical and functional receptor interactions and their physiological and pathological roles. We focus especially on PAR homo- and heterodimerization, transactivation of receptor tyrosine kinases (RTKs) and receptor serine/threonine kinases (RSTKs), communication with other GPCRs, toll-like receptors and NOD-like receptors, ion channel receptors, and on PAR association with cargo receptors. In addition, we discuss the suitability of these receptor interaction mechanisms as targets for modulating PAR signalling in disease. PMID:24215724

  16. Study of the anodic process in the electrolysis of molten chlorides. Application to the chlorine electrode; Contribution a l'etude du processus anodique dans l'electrolyse des chlorures fondus. Application a l'electrode de chlore

    Energy Technology Data Exchange (ETDEWEB)

    Fondanaiche, J.C. [Commissariat a l' Energie Atomique, Fontenay-aux-Roses (France). Centre d' Etudes Nucleaires

    1967-05-01

    P (creee par un apport exterieur de chlore). Cette propriete de la reaction d'oxydation des ions Cl{sup -} nous a permis de proposer une methode electrochimique pour l'etude de l'equilibre d'absorption du chlore entre une phase solide et une phase liquide. Nous pouvons, en effet, remplacer l'apport exterieur de chlore sous une pression P par une electrolyse sous une densite de courant I. Nous avons developpe un schema qui rend compte de la cinetique de la reaction de decharge des ions Cl{sup -}. Il a ete verifie a l'aide des courbes intensite-potentiel et des courbes potentiel-temps caracterisant la depolarisation du carbone en circuit ouvert. Deux methodes ont ete utilisees pour la mesure de la quantite de chlore adsorbe sur le carbone. Les liaisons des molecules de chlore adsorbe sur le carbone et la surface d'echange electrode-electrolyte ont pu etre precisees en faisant varier la temperature, la nature de l'electrode et de l'electrolyte. Certaines anomalies et en particulier certains phenomenes transitoires, ont ete expliques par l'influence de l'oxygene present dans le sel fondu sous forme d'ions O{sup 2-} et a la surface de l'electrode, sous forme de complexes de chimisorption. (auteur)

  17. Identification of uPAR-positive chemoresistant cells in small cell lung cancer.

    Directory of Open Access Journals (Sweden)

    Margarita Gutova

    Full Text Available BACKGROUND: The urokinase plasminogen activator (uPA and its receptor (uPAR/CD87 are major regulators of extracellular matrix degradation and are involved in cell migration and invasion under physiological and pathological conditions. The uPA/uPAR system has been of great interest in cancer research because it is involved in the development of most invasive cancer phenotypes and is a strong predictor of poor patient survival. However, little is known about the role of uPA/uPAR in small cell lung cancer (SCLC, the most aggressive type of lung cancer. We therefore determined whether uPA and uPAR are involved in generation of drug resistant SCLC cell phenotype. METHODS AND FINDINGS: We screened six human SCLC cell lines for surface markers for putative stem and cancer cells. We used fluorescence-activated cell sorting (FACS, fluorescence microscopy and clonogenic assays to demonstrate uPAR expression in a subpopulation of cells derived from primary and metastatic SCLC cell lines. Cytotoxic assays were used to determine the sensitivity of uPAR-positive and uPAR-negative cells to chemotherapeutic agents. The uPAR-positive cells in all SCLC lines demonstrated multi-drug resistance, high clonogenic activity and co-expression of CD44 and MDR1, putative cancer stem cell markers. CONCLUSIONS: These data suggest that uPAR-positive cells may define a functionally important population of cancer cells in SCLC, which are resistant to traditional chemotherapies, and could serve as critical targets for more effective therapeutic interventions in SCLC.

  18. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  19. The urokinase receptor (uPAR facilitates clearance of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Joppe W R Hovius

    2009-05-01

    Full Text Available The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR; however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity and PAI-1 (high fibrinolytic activity knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1beta mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system.

  20. The Urokinase Receptor (uPAR) Facilitates Clearance of Borrelia burgdorferi

    Science.gov (United States)

    Hovius, Joppe W. R.; Bijlsma, Maarten F.; van der Windt, Gerritje J. W.; Wiersinga, W. Joost; Boukens, Bastiaan J. D.; Coumou, Jeroen; Oei, Anneke; de Beer, Regina; de Vos, Alex F.; Veer, Cornelis van 't; van Dam, Alje P.; Wang, Penghua; Fikrig, Erol; Levi, Marcel M.; Roelofs, Joris J. T. H.; van der Poll, Tom

    2009-01-01

    The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR); however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity) and PAI-1 (high fibrinolytic activity) knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1β mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system. PMID:19461880

  1. uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder

    DEFF Research Database (Denmark)

    Dohn, Line Hammer; Pappot, Helle; Iversen, Benedikte Richter

    2015-01-01

    The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling...... during cancer invasion and metastasis and is an established prognostic marker in various cancer diseases other than bladder cancer. Formalin-fixed and paraffin-embedded tumour-tissue blocks from 186 patients treated with radical cystectomy were analysed. uPAR expression was scored as either negative...

  2. Los parásitos de los animales domésticos.

    OpenAIRE

    Cruz B. Luis

    2012-01-01

    Desde el año 1937, el Departamento Nacional de Agricultura, desean prestar un servicio más efectivo para el agricultor costarricense, viene publicando en su Revista Agrícola, artículos referentes a los parásitos que infestan nuestro ganados e incluyendo siempre las medidas más prácticas para su control. Durante muchos años, los parásitos de los animales han constituido un verdadero flagelo para la industria costarricense, entorpeciendo su progreso; pero desde que el Servicio de Par...

  3. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  4. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  5. Etude du processus de changement vecu par des familles ayant decide d'adopter volontairement des comportements d'attenuation des changements climatiques

    Science.gov (United States)

    Leger, Michel T.

    Les activites humaines energivores telles l'utilisation intensive de l'automobile, la surconsommation de biens et l'usage excessif d'electricite contribuent aux changements climatiques et autres problemes environnementaux. Bien que plusieurs recherches rapportent que l'etre humain est de plus en plus conscient de ses impacts sur le climat de la planete, ces memes recherches indiquent qu'en general, les gens continuent a se comporter de facon non ecologique. Que ce soit a l'ecole ou dans la communaute, plusieurs chercheurs en education relative a l'environnement estiment qu'une personne bien intentionnee est capable d'adopter des comportements plus respectueux de l'environnement. Le but de cette these etait de comprendre le processus d'integration de comportements d'attenuation des changements climatiques dans des familles. A cette fin, nous nous sommes fixe deux objectifs : 1) decrire les competences et les procedes qui favorisent l'adoption de comportements d'attenuation des changements climatiques dans des familles et 2) decrire les facteurs et les dynamiques familiales qui facilitent et limitent l'adoption de comportements d'attenuation des changements climatiques dans des familles. Des familles ont ete invitees a essayer des comportements personnels et collectifs d'attenuation des changements climatiques de sorte a integrer des modes de vie plus ecologiques. Sur une periode de huit mois, nous avons suivi leur experience de changement afin de mieux comprendre comment se produit le processus de changement dans des familles qui decident volontairement d'adopter des comportements d'attenuation des changements climatiques. Apres leur avoir fourni quelques connaissances de base sur les changements climatiques, nous avons observe le vecu de changement des familles durant huit mois d'essais a l'aide de journaux reflexifs, d'entretiens d'explicitation et du journal du chercheur. La these comporte trois articles scientifiques. Dans le premier article, nous presentons une

  6. Contribution to the study of the interaction of slow neutrons with {sup 235}U using the time-of-flight method; Contribution a l'etude par la methode du temps de vol de l'interaction de neutrons lents avec l'U{sup 235}

    Energy Technology Data Exchange (ETDEWEB)

    Michaudon, A. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1964-05-15

    This study concerns the properties of the excited levels of uranium 236 obtained by interaction of slow neutron with uranium 235. The experiments have been carried out at the Saclay linear electron accelerator by use of the time of flight method. In the first part of this paper, we examine the technical and physical conditions which rule the experiments: compromise between resolution and counting rate, time dispersion due to the slowing down of the neutrons and crystalline binding effects. In a second part the experimental results i.e. total, fission and ternary fission cross sections are given. The third part deals with the analysis of these results: the resonance parameters determination ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), the study of their statistical distribution and of their correlations. We tried some classifications of the resonances according to their parameters and compared these classifications to each other and to other results. At least the evidence of a cross section correlation with a range smaller than 100 eV seems to be confirmed. (author) [French] Cette etude porte sur les proprietes des niveaux excites de l'Uranium-236 obtenus par l'interaction de neutrons lents avec le {sup 235}U. La technique experimentale est celle de la spectrometrie par temps de vol, les experiences ayant ete realisees aupres de l'accelerateur lineaire d'electrons de Saclay, Dans une premiere partie nous examinons les donnees techniques et physiques conditionnant les experiences: compromis entre resolution et taux de comptage, dispersion en temps due au ralentissement des neutrons, effet des liaisons cristallines. Dans une deuxieme partie sont exposes les resultats experimentaux: sections efficaces totales, de fission et de fission ternaire du {sup 235}U. Une troisieme partie porte sur l'analyse de ces resultats: determination des parametres ({tau}{sub n}, {tau}{sub {gamma}}, {tau}{sub f}), etude de leurs distributions statistiques et

  7. Data on the regulation of moesin and merlin by the urokinase receptor (uPAR): Model explaining distal activation of integrins by uPAR.

    Science.gov (United States)

    Degryse, Bernard; Britto, Mishan; Shan, Chun Xu; Wallace, Robert G; Rochfort, Keith D; Cummins, Philip M; Meade, Gerardene; Murphy, Ronan P

    2017-12-01

    The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012) [1], in which we investigated the functional connections between the urokinase receptor (uPAR), and the ezrin/radixin/moesin (ERM) proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC). Additional data compare the effects of urokinase (uPA, the main ligand of uPAR) on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively.

  8. Data on the regulation of moesin and merlin by the urokinase receptor (uPAR: Model explaining distal activation of integrins by uPAR

    Directory of Open Access Journals (Sweden)

    Bernard Degryse

    2017-12-01

    Full Text Available The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012 [1], in which we investigated the functional connections between the urokinase receptor (uPAR, and the ezrin/radixin/moesin (ERM proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC. Additional data compare the effects of urokinase (uPA, the main ligand of uPAR on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively. Keywords: Urokinase receptor, Moesin, Merlin, Angiogenesis, siRNA

  9. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR), thereby exploring the possibility of replacing the blood sample with an easy obtainable urine sample. We enrolled 1,007 adults, older than 15 years of age, with a negative TB diagnosis between April 2004 and December 2006. Levels of U-suPAR and P-suPAR were available in 863 individuals. U......-suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  10. [Fiberless miniature chandelier LED endoilluminator for pars plana vitrectomy].

    Science.gov (United States)

    Kölbl, P S; Lindner, C; Lingenfelder, C; Deuchler, S; Singh, P; Koch, F H J; Heßling, M

    2016-01-01

    Currently available chandelier endoilluminators for pars plana vitrectomy consist of conventional optical fibers coupled to a light source. The light probes of these fibers now provide wide emittance angles but it is still often not possible to illuminate the whole intraocular space via just one incision. Therefore, several light probes or additional handheld endoilluminators have to be used simultaneously or the lights have to be repositioned during surgery. The presented prototype of a fiberless chandelier light-emitting diode (LED) endoilluminator aims at illuminating the whole intraocular space with just one incision while reducing the risk of harming the retina. The light source is a white LED with a conical tip that allows stable fixation within an incision. The physical properties of these LEDs were determined and used for calculating the relevant irradiance to assess the risk of causing harm to the eye. The illumination of the intraocular space was investigated using porcine eyes. The illumination of porcine eyes with the modified LEDs was bright and homogeneous. Measurements and subsequent calculations proved that the expected thermal load and photochemical hazard were very low for human eyes. The hitherto existing experimental results on porcine eyes and the theoretical considerations on human eyes were found to be positive; therefore, it is expected that this new fiberless chandelier LED endoilluminator will prove to be advantageous for human patients. It promises a reduced number of incisions with a simplified handling and need to add handheld light sources only if minimal intensity oblique illumination is helpful together with the chandelier illumination. This contributes to a significant reduction of phototoxicity risks and additionally there is a chance for a cost reduction because expensive xenon or mercury lamps are no longer necessary. These expectations have to be verified by further studies on human eyes.

  11. Mesencephalic origin of the rostral Substantia nigra pars reticulata.

    Science.gov (United States)

    Madrigal, M Pilar; Moreno-Bravo, Juan A; Martínez-López, Jesús E; Martínez, Salvador; Puelles, Eduardo

    2016-04-01

    In embryonic development, the neurons that will constitute a heterogeneous nucleus may have distinct origins. The different components of these populations reach their final location by radial and tangential migrations. The Substantia nigra pars reticulata (SNR) presents a high level of neuronal heterogeneity. It is composed by GABAergic neurons located in the mes-diencephalic basal plate. These inhibitory neurons usually display tangential migrations and it has been already described that the caudal SNR is colonized tangentially from rhombomere 1. Our aim is to unveil the origin of the rostral SNR. We have localized a Nkx6.2 positive ventricular domain located in the alar midbrain. Nkx6.2 derivatives' fate map analysis showed mainly a rostral colonization of this GABAergic neuronal population. We confirmed the mesencephalic origin by the expression of Six3. Both transcription factors are sequentially expressed along the differentiation of these neurons. We demonstrated the origin of the rostral SNR; our data allowed us to postulate that this nucleus is composed by two neuronal populations distributed in opposite gradients with different origins, one from rhombomere 1, caudal to rostral, and the other from the midbrain, rostral to caudal. We can conclude that the SNR has multiple origins and follows complex mechanisms of specification and migration. Our results support vital information for the study of genetic modifications in these extremely complex processes that result in devastating behavioral alterations and predisposition to psychiatric diseases. Understanding the development, molecular identity and functional characteristics of these diverse neuronal populations might lead to better diagnosis and treatment of several forms of neurological and psychiatric disease.

  12. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  13. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....

  14. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  15. PAR-Aware Large-Scale Multi-User MIMO-OFDM Downlink

    CERN Document Server

    Studer, Christoph

    2012-01-01

    We investigate an orthogonal frequency-division multiplexing (OFDM)-based downlink transmission scheme for large-scale multi-user (MU) multiple-input multiple-output (MIMO) wireless systems. The use of OFDM causes a high peak-to-average (power) ratio (PAR), which necessitates expensive and power-inefficient radio-frequency (RF) components at the base station. In this paper, we present a novel downlink transmission scheme, which exploits the massive degrees-of-freedom available in large-scale MU-MIMO-OFDM systems to achieve low PAR. Specifically, we propose to jointly perform MU precoding, OFDM modulation, and PAR reduction by solving a convex optimization problem. We develop a corresponding fast iterative truncation algorithm (FITRA) and show numerical results to demonstrate tremendous PAR-reduction capabilities. The significantly reduced linearity requirements eventually enable the use of low-cost RF components for the large-scale MU-MIMO-OFDM downlink.

  16. BOREAS TE-09 PAR & Leaf Nitrogen Data for NSA, R1

    Data.gov (United States)

    National Aeronautics and Space Administration — This data table contains data collected by TE09 on the relationship between PAR and foliage nitrogen in the canopies of NSA-OBS, NSA-UBS, NSA-YJP, NSA-OJP and...

  17. A biomechanic study of the surgical repair technique of pars defect in spondylolysis.

    Science.gov (United States)

    Vathana, P; Prasartritha, T

    1998-11-01

    To find out which wiring technique of direct repair of the pars defect is the strongest in resisting anteroposterior translation displacement, fifteen fresh human cadaveric L4-L5 spines were biomechanically tested by a universal testing machine. Two millimeters wide pars defect was created on both sides of L4 vertebrae. Each of the five specimens was wired using Nicol's technique (A), modified Nicol's technique (B) and modified pedicular screw technique respectively (C). At each test, motion was observed to occur initially at the pars defect. The mean minimum tensile strength (increment of the pars defect) for technique A, B and C was 87.64, 82.04 and 110.08 Kg Force respectively. By statistical analysis, technique C was the strongest in resisting anteroposterior displacement of the spinal column. There was no statistically significant difference between technique A and B.

  18. PARS PLANA VITRECTOMY FOR LATE VITREORETINAL SEQUELAE OF INFECTIOUS ENDOPHTHALMITIS: Surgical Management and Outcomes.

    Science.gov (United States)

    Thomas, Benjamin J; Mehta, Neesurg; Yonekawa, Yoshihiro; Sridhar, Jayanth; Kuriyan, Ajay E; Relhan, Nidhi; Liang, Michelle C; Woodward, Maria A; Witkin, Andre J; Shah, Chirag; Flynn, Harry W; Garg, Sunir J; Wolfe, Jeremy D

    2017-04-01

    To report the visual acuity outcomes after pars plana vitrectomy for delayed vitreoretinal sequelae of infectious endophthalmitis. All eyes were initially treated with intravitreal antibiotics (Abx). Multicenter, retrospective, consecutive case series. Forty-two eyes met the study criteria. The mean follow-up was 48 weeks (SD ± 61.8). Mean interval from Abx to pars plana vitrectomy was 13 weeks (SD ± 14.3, range 2-70). Indications for pars plana vitrectomy included vitreous opacities (VO) (n = 22), epiretinal membrane (n = 9), and retinal detachment (n = 11). LogMAR visual acuity improved from 1.87 (Snellen equivalent: 20/1,482) preoperatively to 1.35 (Snellen equivalent: 20/447) at final evaluation (P pars plana vitrectomy for delayed sequelae such as vitreous opacities or for retinal detachment.

  19. Detection of pars plana rupture by ultrasound biomicroscopy after cannula dislodgement during cataract wound hydration.

    Science.gov (United States)

    Yonekawa, Yoshihiro; Thomas, Benjamin J; Lau-Sickon, Laurie K; Anderson, Bradley J; Ruby, Alan J

    2017-01-01

    Ultrasound biomicroscopy (UBM) is a valuable diagnostic modality for imaging anterior ocular structures. Its utility has been well studied in anterior segment, lenticular, and pars plicata pathologies. However, imaging of the pars plana has been seldom described. We present the case of a 66-year-old woman referred for vitreous hemorrhage after expulsive cannula dislodgement into the posterior segment during wound hydration at the end of cataract surgery. B-scan ultrasonography initially detected a very anterior abnormality, but the resolution was insufficient for accurate diagnosis. Subsequent UBM clearly showed rupture of the pars plana and a mild cyclodialysis cleft. To our knowledge, this is the first report of a pars plana rupture detected by ultrasound, which expands the diagnostic capacities and indications for UBM.

  20. Inmunidad frente a infecciones: bacterias, virus, hongos y parásitos

    OpenAIRE

    Sen Fernández, María Luz de la; Sempere Ortells, José Miguel; Marco de la Calle, Francisco Manuel; Vázquez Araujo, Begoña

    2012-01-01

    Respuesta inmune frente a la infección: Bacterias extracelulares, bacterias intracelulares, hongos, virus, parásitos. Inmunidad innata, inmunidad adaptativa, mecanismos de evasión, consecuencias perjudiciales de la respuesta inmune.

  1. Application of passive auto catalytic recombiner (PAR) for BWR plants in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Kobayashi, K.; Murano, K. [Tokyo Electric Power Co., Inc. (Japan); Yamanari, S. [Hitachi Cable, Ltd., Tokyo (Japan); Yamamoto, Y. [Toshiba Corp., Yokohama (Japan)

    2001-07-01

    The passive auto-catalytic recombiner (PAR), which can recombine flammable gases such as hydrogen and oxygen with each other to avoid an explosion in case of a loss-of-coolant accident (LOCA), installed in the primary containment vessel does not require a power supply or dynamic equipment, while the existing flammability gas control system (FCS) of most BWRs as an outer loop of the primary containment vessel needs them to make flammable gases circulate through blowers and heaters in the system. PAR offers a number of advantages over existing FCS, such as high reliability, low cost due to much smaller amount of materials needed, good maintainability, good operability in case of a LOCA, and smaller space for installation. An experimental study has been carried out for the purpose of solving the problems of applying PAR to Japanese BWR plants instead of existing FCS, in which we grasped the basic characteristics of PAR. (author)

  2. A PROSPECTIVE, RANDOMIZED STUDY OF PERIPROSTATIC

    African Journals Online (AJOL)

    plus efficace que Finstillation intrarectale de 15 ml de gel de lidocaine at 2% , qui a son tour etait plus efficace que le lubrifiant intrarectal (placebo) gel. La frequence cle complications n'a pas ete augmentee apres injection de la lidocaine en peri prostatique. Bien que la plus grande douleur alt ete eprouvee par le malade.

  3. Paracoccidioides brasiliensis induces cytokine secretion in epithelial cells in a protease-activated receptor-dependent (PAR) manner.

    Science.gov (United States)

    de Oliveira, Priscila; Juliano, Maria Aparecida; Tanaka, Aparecida Sadae; Carmona, Adriana Karaoglanovic; Dos Santos, Saara Maria Batista; de Barros, Bianca Carla Silva Campitelli; Maza, Paloma Korehisa; Puccia, Rosana; Suzuki, Erika

    2017-04-01

    Paracoccidioides brasiliensis is one of the etiological agents of the human systemic mycosis paracoccidioidomycosis. Protease-activated receptors (PARs) are expressed in many cell types and comprise a family of G protein-coupled receptors (PAR-1, PAR-2, and PAR-4), which may be activated by proteases secreted by several pathogens. In the present study, we showed that the pathogenic fungus P. brasiliensis secretes components that promote interleukin (IL)-6 and IL-8 secretion by the lung epithelial cell line A549. Cytokine secretion was reduced by antagonistic peptides for PAR-1 and PAR-2, but not for PAR-4. P. brasiliensis proteases were isolated from fungal culture supernatants in a p-aminomethylbenzamidine-Sepharose column. The obtained fractions were tested for enzymatic activity against fluorescence resonance energy transfer (FRET) peptides derived from sequences that spanned the activation sites of human PARs. The eluted fraction, termed PbP, contained protease activities that were able to hydrolyze the FRET peptides. PbP also induced IL-6 and IL-8 secretion in A549 epithelial cells, which was reduced upon heat inactivation of PbP, incubation with antagonistic peptides for PAR-1 and PAR-2, and the protease inhibitors aprotinin, leupeptin, and E-64. Together, these results show for the first time that P. brasiliensis yeasts secrete proteases that activate PARs in lung epithelial cells, leading to cytokine secretion.

  4. Características morfológicas da pars de C2 de humanos Características morfológicas de la pars de C2 de humanos Morphologic characteristics of C2 humans pars

    Directory of Open Access Journals (Sweden)

    Charles André Carazzo

    2009-09-01

    Full Text Available OBJETIVO: avaliar a morfometria da pars da segunda vértebra cervical, verificar as variações existentes e predizer sua segurança para a colocação de parafusos por meio de uma abordagem cervical posterior. MÉTODOS: 58 vértebras foram obtidas para estudo anatômico (116 pars de C2 e foram medidas a altura e largura da pars, além do comprimento eixo-pedículo, largura e comprimento do pedículo, angulação sagital e medial. Todas as medidas foram separadas quanto aos seus lados direito e esquerdo; foi realizado o cálculo da média, variação, desvio padrão e a médica foi comparada com os estudos prévios. RESULTADOS: a largura média da pars de C2 foi de 9,5 mm; a altura, 9,5 mm; não houve diferença significativa entre os lados esquerdo e direito. O comprimento médio do pedículo foi de 10,5 mm; a medida média encontrada para o comprimento eixo-pedículo foi de 24,9 mm; a largura do pedículo foi de 2,8 mm. A angulação sagital encontrada foi de 19,6º e a horizontal foi de 28,5º. CONCLUSÕES: este estudo demonstra a viabilidade para a colocação de parafuso na pars de C2 em uma população caucasiana, destacando-se, porém, a grande variabilidade anatômica encontrada nas referidas medidas.OBJETIVO: evaluar la morfometría de la pars de la segunda vértebra cervical, verificar las variaciones existentes y predecir su seguridad para la colocación de los tornillos por un abordaje cervical posterior. MÉTODOS: 58 vértebras fueron obtenidas para el estudio anatómico (116 pars de C2 y fueron medidas su altura y el ancho de las pars, además de la largura eje-pedículo, ancho y largura del pedículo, ángulo sagital y medial. Todas las medidas fueron separadas según sus lados derecho e izquierdo, se realizó el cálculo de la media, variación, desvío estándar y comparados los valores con estudios previos. RESULTADOS: el ancho promedio de la pars de C2 fue de 9.5 mm, la altura de 9.5 mm, sin diferencia significativa entre los

  5. Surface integral formulation of Maxwell's equations for simulation of non-destructive testing by eddy currents. Preliminary study on the implementation of the fast multipole method; Formulation integrale surfacique des equations de Maxwell pour la simulation de controles non destructifs par courant de Foucault. Etude preliminaire a la mise en oeuvre de la methode multipole rapide.

    Energy Technology Data Exchange (ETDEWEB)

    Lim, T.

    2011-04-28

    numeriquement un controle non destructif par courants de Foucault (CND-CF), la reponse du capteur peut etre modelisee via une approche semi-analytique par integrales de volume. Plus rapide que la methode des elements finis, cette approche est cependant limitee a l'etude de pieces planes ou cylindriques (sans prise en compte des effets de bords) du fait de la complexite de l'expression de la dyade de Green pour des configurations plus generales. Or, il existe une forte demande industrielle pour etendre les capacites de la modelisation CF a des configurations complexes (plaques deformees, bords de piece...). Nous avons donc ete amenes a formuler differemment le probleme electromagnetique, en nous fixant comme objectif de conserver une approche semi-analytique. La formulation integrale surfacique (SIE) permet d'exprimer le probleme volumique en un probleme de transmission equivalent a l'interface (2D) entre sous-domaines homogenes. Ce probleme est ramene a la resolution d'un systeme lineaire (par la methode des moments) dont le nombre d'inconnues est reduit du fait du caractere surfacique du maillage. Des lors, ce systeme peut etre resolu par un solveur direct pour de petites configurations. Cela nous a permis de traiter plusieurs seconds membres (ie. differentes positions de capteurs) pour une seule inversion de la matrice d'impedance. Les resultats numeriques obtenus au moyen de cette formulation concernent des plaques avec la prise en compte des effets de bords tels que l'arete et le coin. Ils sont en accord avec des resultats obtenus par la methode des elements finis. Pour des configurations de grandes tailles, nous avons mene une etude preliminaire a l'adaptation d'une methode d'acceleration du produit matrice-vecteur intervenant dans un solveur iteratif (methode multipole rapide, ou FMM) afin de definir les conditions dans lesquelles le calcul FMM fonctionne correctement (precision, convergence...) dans le contexte CND

  6. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  7. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  8. Expression of guanylin in “pars tuberalis-specific cells” and gonadotrophs of rat adenohypophysis‖

    OpenAIRE

    D'Este, Loredana; Kulaksiz, Hasan; Rausch, Ulrich; Vaccaro, Rosa; Wenger, Tibor; Tokunaga, Yoshimitsu; Renda, Tindaro G.; Cetin, Yalcin

    2000-01-01

    The intestinal peptide guanylin regulates the electrolyte/water transport in the gastrointestinal epithelium by paracrine/luminocrine mechanisms. Because guanylin also circulates in the blood, we investigated the rat hypothalamo-pituitary region for expression and cellular localization of this peptide. Reverse transcriptase–PCR analyses with guanylin-specific primers revealed expression of the peptide in the pars tuberalis and pars distalis of the pituitary. Western blotting analyses in hypop...

  9. Contamination du sol, de l'eau et des produits maraîchers par des ...

    African Journals Online (AJOL)

    ... de l'eau et des produits maraîchers par des substances toxiques et des métaux ... L'usage non maîtrisé d'intrants agricoles et de pesticides a des effets sur la ... maraîchères sont contaminées par des métaux lourds notamment le plomb, ...

  10. Tsitutu , ou mecanisme local de mediation et de reconciliation « par ...

    African Journals Online (AJOL)

    Si le Togo est une nation pluriethnique, du coup, il y en aura des manières particulières de résolution des conflits, donc des réconciliations. Par une approche pluridisciplinaire, cette étude a pour but de restituer le mécanisme local de réconciliation chez les ewe de Kloto. Par ailleurs, ce rituel qui tente de proposer des ...

  11. Endophthalmitis Due to Proteus vulgaris after Pars Plana Vitrectomy with Devastating Outcome.

    Science.gov (United States)

    Al-Kharashi, Abdullah S; Al-Kharshi, Abdulmajeed S; Al-Faky, Yasser H

    2017-01-01

    Postoperative infectious endophthalmitis is rare, yet devastating loss of vision or loss of the eye can occur due to a highly purulent microorganism or uncontrolled endophthalmitis that may spread to all coats of the eye. We report, herewith, a case of rapidly progressive postoperative endophthalmitis after pars plana vitrectomy which ended up with enucleation. The isolated microorganism was Proteus vulgaris which has not been reported as causative bacteria of postoperative infections following pars plana vitrectomy.

  12. 27 Segmentation par logique floue pour l'estimation du nombre de ...

    African Journals Online (AJOL)

    bagui kossan olivier

    modes, par un ensemble de 13 DELs, avec des longueurs d'onde allant de 375nm à 940nm. Une source en ... (13 images par mode), pour la même scène, en utilisant une carte d'acquisition de données (NI-DAQ) couplée ..... malaria diagnostics by multispectral and multimodality light-emitting-diode microscopy. Journal of.

  13. Anatomic relationship between the anterior sylvian point and the pars triangularis.

    Science.gov (United States)

    Ayberk, Giyas; Yagli, O Emre; Comert, Ayhan; Esmer, Ali Firat; Canturk, Nergis; Tekdemir, Ibrahim; Dinc, Hakan

    2012-05-01

    The aim of this study was to show morphological sulcal variations of the pars triangularis of the inferior frontal gyrus and to provide a clearer description of the anterior sylvian point. Thirty-six hemispheres of 18 adult cadavers were studied. The hemispheres were harvested by the classical autopsy method and fixed in 10% formalin solution for three weeks. In six hemispheres, the arteries and veins were filled with colored silicone. The proximal and distal segments of the sylvian fissure, the perpendicular distance of both the anterior sylvian point and inferior rolandic point to the insular cortex and the distances between the anterior ascending ramus and the precentral, central, and postcentral sulcus were measured. The anterior horizontal and ascending rami were exposed. The sulcus located on the pars triangularis was appraised. The relationship between the anterior sylvian point and the vascular structure around the sylvian fissure was examined. The rising of the anterior horizontal and ascending ramus from the sylvian fissure defines the shape of the pars triangularis. The pars triangularis has three shapes: V, U, and Y. In V- and Y-shaped pars triangularis both rami merge but in U-shaped pars triangularis the rami do not merge. The pars triangularis was Y-shaped in 30.76% (4/13) of the right hemispheres and in 50% (7/14) of the left hemispheres; U-shaped in 20.3% (3/13) of the right hemispheres and in 35.71% (5/14) of the left hemispheres; V-shaped in 40.61% (6/13) of the right hemispheres and in 14.29% (2/14) of the left hemispheres. Minimally invasive procedures use basic anatomic landmarks intracranially to reach the targeted area; therefore, exact and detailed knowledge of the anatomy of the sylvian fissure and pars triangularis is of great importance. Copyright © 2011 Wiley Periodicals, Inc.

  14. Les corps etrangers des fosses nasales: Extraction par la pince d ...

    African Journals Online (AJOL)

    Les corps etrangers des fosses nasales: Extraction par la pince d'halsteaD. ... des fosses nasales: Extraction par la pince d'halsteaD. B Amana, E Kpemissi, P Agoda, A Naba-Mouchedou ... Les corps étrangers des fosses nasales représentent 0,94 % des consultations ORL du service. L'âge des patients a varié de 9 mois à ...

  15. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  16. Molecular mechanism of bundle formation by the bacterial actin ParM

    Energy Technology Data Exchange (ETDEWEB)

    Popp, David, E-mail: dpopp@imcb.a-star.edu.sg [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore); Narita, Akihiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Iwasa, Mitsusada [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Maeda, Yuichiro [ERATO ' Actin Filament Dynamics' Project, Japan Science and Technology Corporation, c/o RIKEN Harima Institute at Spring 8, 1-1-1 Kouto, Sayo, Hyogo 679-5148 (Japan); Nagoya University Graduate School of Science, Structural Biology Research Center and Division of Biological Sciences, Furo-cho, Chikusa-ku, Nagoya 464-8601 (Japan); Robinson, Robert C. [Institute of Molecular and Cell Biology, 61 Biopolis Drive, Proteos, 138673 Singapore (Singapore)

    2010-01-22

    The actin homolog ParM plays a microtubule-like role in segregating DNA prior to bacterial cell division. Fluorescence and cryo-electron microscopy have shown that ParM forms filament bundles between separating DNA plasmids in vivo. Given the lack of ParM bundling proteins it remains unknown how ParM bundles form at the molecular level. Here we show using time-lapse TIRF microscopy, under in vitro molecular crowding conditions, that ParM-bundle formation consists of two distinct phases. At the onset of polymerization bundle thickness and shape are determined in the form of nuclei of short helically disordered filaments arranged in a liquid-like lattice. These nuclei then undergo an elongation phase whereby they rapidly increase in length. At steady state, ParM bundles fuse into one single large aggregate. This behavior had been predicted by theory but has not been observed for any other cytomotive biopolymer, including F-actin. We employed electron micrographs of ParM rafts, which are 2-D analogs of 3-D bundles, to identify the main molecular interfilament contacts within these suprastructures. The interface between filaments is similar for both parallel and anti-parallel orientations and the distribution of filament polarity is random within a bundle. We suggest that the interfilament interactions are not due to the interactions of specific residues but rather to long-range, counter ion mediated, electrostatic attractive forces. A randomly oriented bundle ensures that the assembly is rigid and that DNA may be captured with equal efficiency at both ends of the bundle via the ParR binding protein.

  17. La décoloration des rejets liquides de textile (noir de soufre) par ...

    African Journals Online (AJOL)

    Dans cette étude, nous nous intéressons au traitement d'un rejet de coloration de textile par voie électrochimique. Les paramètres qui ont été variés au cours de traitement par cette technique sont le pourcentage de dilution et le courant imposé. Les résultats obtenus ont permis d'obtenir un taux de décoloration pouvant ...

  18. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4.

    Science.gov (United States)

    Gnazzo, Megan M; Uhlemann, Eva-Maria E; Villarreal, Alex R; Shirayama, Masaki; Dominguez, Eddie G; Skop, Ahna R

    2016-10-15

    The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN-4 at the spindle midzone. ATX-2 does this by regulating the amount of PAR-5 at mitotic structures, particularly the spindle, centrosomes, and midbody. Preventing ATX-2 function leads to elevated levels of PAR-5, enhanced chromatin and centrosome localization of PAR-5-GFP, and ultimately a reduction of ZEN-4-GFP at the spindle midzone. Codepletion of ATX-2 and PAR-5 rescued the localization of ZEN-4 at the spindle midzone, indicating that ATX-2 mediates the localization of ZEN-4 upstream of PAR-5. We provide the first direct evidence that ATX-2 is necessary for cytokinesis and suggest a model in which ATX-2 facilitates the targeting of ZEN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5. © 2016 Gnazzo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  19. Willin and Par3 cooperatively regulate epithelial apical constriction through aPKC-mediated ROCK phosphorylation.

    Science.gov (United States)

    Ishiuchi, Takashi; Takeichi, Masatoshi

    2011-06-19

    Apical-domain constriction is important for regulating epithelial morphogenesis. Epithelial cells are connected by apical junctional complexes (AJCs) that are lined with circumferential actomyosin cables. The contractility of these cables is regulated by Rho-associated kinases (ROCKs). Here, we report that Willin (a FERM-domain protein) and Par3 (a polarity-regulating protein) cooperatively regulate ROCK-dependent apical constriction. We found that Willin recruits aPKC and Par6 to the AJCs, independently of Par3. Simultaneous depletion of Willin and Par3 completely removed aPKC and Par6 from the AJCs and induced apical constriction. Induced constriction was through upregulation of the level of AJC-associated ROCKs, which was due to loss of aPKC. Our results indicate that aPKC phosphorylates ROCK and suppresses its junctional localization, thereby allowing cells to retain normally shaped apical domains. Thus, we have uncovered a Willin/Par3-aPKC-ROCK pathway that controls epithelial apical morphology.

  20. Examining relational empowerment for elementary school students in a yPAR program.

    Science.gov (United States)

    Langhout, Regina Day; Collins, Charles; Ellison, Erin Rose

    2014-06-01

    This paper joins relational empowerment, youth empowerment, and Bridging Multiple Worlds frameworks to examine forms of relational empowerment for children in two intermediary institutions-school and a youth participatory action research after-school program (yPAR ASP). Participants were twelve children, most of whom were Latina/o and from im/migrant families, enrolled in a yPAR ASP for 2 years. A mixed-method approach was utilized; we analyzed children's interviews, self-defined goals, and their social networks to examine their experiences of relational empowerment. We conclude that children experienced each of the five relational empowerment factors-collaborative competence, bridging social divisions, facilitating others' empowerment, mobilizing networks, and passing on a legacy-in the yPAR ASP setting, and some factors in school. These experiences, however, were more pronounced in the yPAR ASP setting. Additionally, social network analyses revealed that a small but meaningful percentage of actors bridged worlds, especially home and family, but by year 2, also school and the yPAR ASP. Finally, most helpers for school-based goals came from school, but a sizable number came from family, friends, and home worlds, and by year 2, also came from the yPAR ASP. Implications range from theoretical to methodological development, including the use of social network analysis as a tool to descriptively examine relational power in context.

  1. Evaluation of orthodontists' perception of treatment need and the peer assessment rating (PAR) index.

    Science.gov (United States)

    McGorray, S P; Wheeler, T T; Keeling, S D; Yurkiewicz, L; Taylor, M G; King, G J

    1999-08-01

    This paper examines the relationship between orthodontists' subjective assessment of treatment need and objective measurements obtained during standardized intra- and extraoral examinations. Logistic regression modeling was used to develop predictive models of treatment need. Data were obtained from 1155 eighth-grade students by four orthodontists who used standardized examination forms to assess demographics, trauma, skeletal relationships, morphologic malocclusion traits, and mandibular function. At the conclusion of the examination, the orthodontist rated the subjective treatment need as none, elective, recommended, soon, or immediate. For some analyses, the categories were collapsed to represent no need and need. The peer assessment rating (PAR) index (American validated version) was computed from the clinical exam findings and scoring of dental models; PAR scores were used to document malocclusion severity and treatment difficulty. Spearman rank correlation coefficients quantified the relationship between PAR scores and need categories. Logistic regression analysis modeled treatment need using components of the PAR index as well as other variables. The components of these models, as well as sensitivity and specificity, were compared with malocclusion severity/treatment difficulty scores obtained from malocclusion assessments using the PAR index. The five subjective treatment need categories and the PAR index scores were significantly correlated (rho = 0.62, porthodontists' subjective assessment of treatment need when that assessment is made in the absence of financial considerations and patient desires.

  2. Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (suPAR) in acute liver failure.

    Science.gov (United States)

    Koch, Alexander; Zimmermann, Henning W; Gassler, Nikolaus; Jochum, Christoph; Weiskirchen, Ralf; Bruensing, Jan; Buendgens, Lukas; Dückers, Hanna; Bruns, Tony; Gerken, Guido; Neumann, Ulf P; Adams, David H; Trautwein, Christian; Canbay, Ali; Tacke, Frank

    2014-10-01

    Acute liver failure (ALF) is a life-threatening condition with a high mortality rate. The expression of urokinase plasminogen activator receptor (uPAR, CD87) and release of its shedded receptor into serum as soluble uPAR (suPAR) have been closely related to immune activation and prognosis in systemic inflammation and cirrhosis. We now aimed at investigating the clinical relevance and cellular source of uPAR and circulating suPAR in ALF. Serum suPAR concentrations were measured in 48 ALF patients and 62 healthy controls from a German liver transplantation centre. Hepatic immune cell subsets and uPAR expression were studied by FACS, qPCR and immunohistochemistry. Circulating suPAR levels were significantly increased in ALF patients, independent from the underlying aetiology, in comparison to controls. Serum suPAR concentrations were closely correlated with parameters reflecting liver cell injury, decreased liver function and the model of end-stage liver disease (MELD) score in ALF patients. By immunohistochemistry from explanted livers, ALF was associated with distinct immune cell accumulation and strong up-regulation of intrahepatic uPAR mRNA expression. CD87 (uPAR) expression was specifically detected on intrahepatic 'non-classical' monocytes (CD14(+) CD16(+) ), NKT and CD56(dim) NK cells isolated from human liver, but not on parenchymal or other non-parenchymal hepatic cell types. Membrane-bound uPAR was rapidly cleaved from monocytes upon inflammatory stimulation by lipopolysaccharide (LPS) and partially by co-cultured lymphocytes. Similar to its prognostic properties in patients with sepsis or cirrhosis, intrahepatic uPAR activation and serum suPAR concentrations might serve as an interesting biomarker in ALF. © 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Les transformateurs rapides pour LEIR et LINAC III

    CERN Document Server

    Lenardon, F; CERN. Geneva. AB Department

    2004-01-01

    L’electronique des transformateurs rapides destines a mesurer les ions est assez classique. La difficulte principale provient de la ligne ETL dans laquelle il nous a ete demande [Ch] de pouvoir mesurer avec le meme transformateur un faisceau injecte de faible intensite (environ 40 10E-6A) et de longue durée (de 250 à 500 10E-6s) et d’un faisceau ejecte de plus forte intensite (environ 160 mA) et de courte duree (environ 100 à 200 ns). Cette note presente globalement le systeme et decrit l’electronique utilisee.

  4. Etiología en parálisis cerebral.

    Directory of Open Access Journals (Sweden)

    Patricia Campos

    1996-07-01

    Full Text Available Objetivo: Determinar las causas mas frecuentes de parálisis cerebral (PC. Material y métodos: Estudio descriptivo realizado en Hospital Nacional Cayetano Heredia y el Hogar Clínica San Juan de Dios (Lima-Perú, entre noviembre 1990 y mayo de 1992. Se revisaron las historias clínicas de 102 pacientes con diagnósticos de PC y se revisó las etiologías. Resultados: En relación a edad gestacional hubieron 15 casos de prematuros (14.7%, 67(65% a término y un postmaduro, en 19 no se tuvo la edad gestacional. El peso al nacer fue adecuado en 56(54.9%, bajo en 17(16.7% y muy bajo en 7(6.9%. Se identificó la causa de PC en 73/102 casos (70%, siendo las causas más frecuentes las perinatales (59.3%, seguidas de las prenatales con 29.1% y las postnatales con 11.6%. En el grupo de causas prenatales, la mitad fueron malformaciones cerebrales congénitas entre las que destaca el quiste porencefálico, presente en la mitad de estos casos. En el grupo perinatal, la más frecuente fue asfixia (83% asociada o no a otro factor metabólico. Hubieron además en este grupo 4 casos de hipoglicemia severa y 2 con encefalopatía hiperbilirrubinémica y PC distónica. Las causas postnatal más frecuente fue la meningoencefalitis bacteriana, en menores de un año de edad. Al correlacionar etiología y momento del daño, peso al nacer y tipo de PC se observa que, en los recién nacidos PT de bajo o muy bajo peso al nacer es mas frecuente la PC de tipo dipléjica y en todos el antecedente fue asfixia perinatal. Conclusiones: La baja frecuencia de PC dipléjica y la elevada frecuencia de causas perinatales (asfixia, marca nuestra diferencia con otras series y obedece en nuestra opinión, a los escasos recursos tecnológicos y las deficiencias en la atención a las gestantes y recién nacidos de nuestro sistema nacional de salud. (Rev Med Hered 1996; 7: 114-118.

  5. Detection of airborne Par j 1 and Par j 2 allergens in relation to Urticaceae pollen counts in different bioclimatic areas.

    Science.gov (United States)

    Jato, Victoria; Rodríguez-Rajo, F Javier; González-Parrado, Zulima; Elvira-Rendueles, Belén; Moreno-Grau, Stella; Vega-Maray, Ana; Fernández-González, Delia; Asturias, Juan A; Suárez-Cervera, María

    2010-07-01

    In aerobiological studies, the Parietaria pollen type usually includes all Parietaria and Urtica species found in the area. Given that Urtica is a nonallergenic plant, the pollen counts report incomplete information on the presence of allergens in the atmosphere. Discordance between the pollen concentrations of Urticaceae and allergic symptoms has been observed in patients with pollinosis. To compare the Urticaceae pollen counts with the Par j 1 and Par j 2 aeroallergen concentrations from 2 different Spanish geographic areas to determine the allergenic load in the atmosphere. Hirst-type volumetric traps and Burkard Cyclone samplers were used for pollen counts and aeroallergen capture, respectively. The quantification of Par j 1 and Par j 2 allergens was performed using specific 2-site antibody enzyme-linked immunosorbent assay. Transmission electron microscopy and immunocytochemical techniques were applied to localize these allergens in the orbicules. Differences between areas and years were obtained in both pollen and aeroallergen concentrations. Despite the lower pollen counts recorded in Cartagena, higher aeroallergen concentrations were registered compared with Ourense. A lower correlation was achieved between Urticaceae pollen concentrations and aeroallergen levels, with a maximum positive significant correlation (adjusted R2 = 0.466, P Parietaria aeroallergens and clinical symptoms. Therefore, the measurement of aeroallergens should be incorporated into the aerobiological studies with clinical applications.

  6. Control of Smc Coiled Coil Architecture by the ATPase Heads Facilitates Targeting to Chromosomal ParB/parS and Release onto Flanking DNA

    Science.gov (United States)

    Minnen, Anita; Bürmann, Frank; Wilhelm, Larissa; Anchimiuk, Anna; Diebold-Durand, Marie-Laure; Gruber, Stephan

    2016-01-01

    Summary Smc/ScpAB promotes chromosome segregation in prokaryotes, presumably by compacting and resolving nascent sister chromosomes. The underlying mechanisms, however, are poorly understood. Here, we investigate the role of the Smc ATPase activity in the recruitment of Smc/ScpAB to the Bacillus subtilis chromosome. We demonstrate that targeting of Smc/ScpAB to ParB/parS loading sites is strictly dependent on engagement of Smc head domains and relies on an open organization of the Smc coiled coils. We find that dimerization of the Smc hinge domain stabilizes closed Smc rods and hinders head engagement as well as chromosomal targeting. Conversely, the ScpAB sub-complex promotes head engagement and Smc rod opening and thereby facilitates recruitment of Smc to parS sites. Upon ATP hydrolysis, Smc/ScpAB is released from loading sites and relocates within the chromosome—presumably through translocation along DNA double helices. Our findings define an intermediate state in the process of chromosome organization by Smc. PMID:26904953

  7. Heat stress-induced disruption of endothelial barrier function is via PAR1 signaling and suppressed by Xuebijing injection.

    Directory of Open Access Journals (Sweden)

    Qiulin Xu

    Full Text Available Increased vascular permeability leading to acute lung injury (ALI and acute respiratory distress syndrome (ARDS is central to the pathogenesis of heatstroke. Protease-activated receptor 1 (PAR1, the receptor for thrombin, plays a key role in disruption of endothelial barrier function in response to extracellular stimuli. However, the role of PAR1 in heat stress-induced endothelial hyper-permeability is unknown. In this study, we measured PAR1 protein expression in heat-stressed human umbilical venous endothelial cells (HUVECs, investigated the influences of PAR1 on endothelial permeability, F-actin rearrangement, and moesin phosphorylation by inhibiting PAR1 with its siRNA, neutralizing antibody (anti-PAR1, specific inhibitor(RWJ56110, and Xuebijing injection (XBJ, a traditional Chinese medicine used for sepsis treatment, and evaluated the role of PAR1 in heatstroke-related ALI/ARDS in mice by suppressing PAR1 with RWJ56110, anti-PAR1and XBJ. We found that heat stress induced PAR1 protein expression 2h after heat stress in endothelial cells, caused the release of endothelial matrix metalloprotease 1, an activator of PAR1, after 60 or 120 min of heat stimulation, as well as promoted endothelial hyper-permeability and F-actin rearrangement, which were inhibited by suppressing PAR1 with RWJ56110, anti-PAR1 and siRNA. PAR1 mediated moesin phosphorylation, which caused F-actin rearrangement and disruption of endothelial barrier function. To corroborate findings from in vitro experiments, we found that RWJ56110 and the anti-PAR1 significantly decreased lung edema, pulmonary microvascular permeability, protein exudation, and leukocytes infiltrations in heatstroke mice. Additionally, XBJ was found to suppress PAR1-moesin signal pathway and confer protective effects on maintaining endothelial barrier function both in vitro and in vivo heat-stressed model, similar to those observed above with the inhibition of PAR1. These results suggest that PAR1 is a

  8. Stereochemistry and mechanism of the reduction of some bicyclo (2-2-1-) heptane-2-ones by metals dissolved in liquid ammonia; Stereochimie et mecanisme de la reduction de quelques bicyclo (2-2-1) heptanones-2 par les metaux dissous dans l'ammoniac liquide

    Energy Technology Data Exchange (ETDEWEB)

    Coulombeau, A. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1969-07-01

    A systematic experimental study of the reduction of four bicyclo(2-2-1)hepta n-2-ones by dissolved alkaline and alkaline-earth metals in liquid ammonia is reported. Chapter one: models of metal-ammonia solutions and mechanisms of the reduction of ketones by these solutions are rapidly recalled. Chapter two: results obtained in the thermodynamic equilibration of three pairs of epimeric alcohols which formally derive from three of the starting ketones are presented. Chapter three: deals with the results obtained in the reduction of the ketones in the absence or the presence of a proton source. A new interpretation of these results is given and is based upon two different effects: - the torsional interaction created by the bridgehead substituent on the C-O bond which favours the formation of the endo alcohol; - the difference of steric hindrance between the two sides (exo and endo) defined by the plane of the carbonyl group of the starting molecule, which favours the attack of the metal cation from one side or the other, and therefore the formation of the exo or the endo epimer. This mechanism is generalised in a model which is tested by means of some examples published in the literature. It then appears able to construe correctly the obtained results. (author) [French] Une etude experimentale systematique de la reduction de quatre bicyclo-(2-2-1)heptanones-2 par les metaux alcalins et alcalino-terreux dissous dans l'ammoniac liquide a ete effectuee. 1er chapitre: on y rappelle rapidement les modeles proposes pour la structure des solutions metalliques dans l'ammoniac liquide, ainsi que les mecanismes de reduction des cetones par ces solutions. 2eme chapitre: on y presente les resultats obtenus lors de l'equilibration thermodynamique de trois couples d'alcools epimeres derivant de trois des cetones reduites. 3eme chapitre: il concerne les resultats obtenus lors de la reduction des cetones en l'absence ou en presence de donneurs de protons. Une

  9. Modelisation microstructurale en fatigue/fluage a froid des alliages de titane quasi alpha par le modele des automates cellulaires

    Science.gov (United States)

    Boutana, Mohammed Nabil

    Les proprietes d'emploi des alliages de titane sont extremement dependantes a certains aspects des microstructures developpees lors de leur elaboration. Ces microstructures peuvent etre fortement heterogenes du point de vue de leur orientation cristallographique et de leur repartition spatiale. Leurs influences sur le comportement du materiau et son endommagement precoce sont des questions qui sont actuellement soulevees. Dans le present projet de doctorat on chercher a repondre a cette question mais aussi de presenter des solutions tangibles quant a l'utilisation securitaire de ces alliages. Un nouveau modele appele automate cellulaire a ete developpe pour simuler le comportement mecanique des alliages de titane en fatigue-fluage a froid. Ces modeles ont permet de mieux comprendre la correlation entre la microstructure et le comportement mecanique du materiau et surtout une analyse detaillee du comportement local du materiau. Mots-cles: Automate cellulaire, fatigue/fluage, alliage de titane, inclusion d'Eshelby, modelisation

  10. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  11. Detection of pars injury by SPECT in patients younger than age 10 with low back pain.

    Science.gov (United States)

    Spencer, Hillard T; Sokol, Levi O; Glotzbecker, Michael P; Grant, Frederick D; d'Hemecourt, Pierre A; Micheli, Lyle J; Treves, S Ted

    2013-06-01

    Evaluation of extension-based low back pain in young athletes with suspected pars injury may include a referral for skeletal single photon emission computed tomography (SPECT). However, the diagnostic yield of this technique in children with low back pain before the age of 10 years remains uncertain. We examined a series of consecutive SPECT scans to address this question. A retrospective review of department databases revealed 107 consecutive skeletal Tc-99m MDP SPECT scans performed between January 1, 2007 and December 31, 2009 in children less than 10 years of age. Of these, 72 studies were performed for a referral diagnosis of back pain. There were 43 girls (44 studies) and 28 boys (28 studies). The mean age was 7.2 years (range, 1.9 to 9.9 y). All SPECT scans were reviewed and positive findings documented. In addition, all available anatomic imaging, imaging reports (computed tomography, magnetic resonance, and x-ray) and clinical notes were reviewed, and results were compared with those of SPECT studies. Of the 72 SPECT studies, 35 (49%) identified a focal area in the spine of abnormal increased uptake, with 17 in the region of the pars interarticularis. With additional imaging, 1 case was demonstrated not to be a pars injury (computed tomography showed a transverse process fracture) and 2 patients with negative SPECT scans were shown to have pars injuries that SPECT scan had not detected, for a total of 18 pars injuries (25%) in this cohort. Reported participation in gymnastics or football was related to pars injury (odds ratio 4.3, P=0.04). Pars injury was found in 25% of children referred for SPECT scan with back pain below 10 years of age. SPECT scan was highly sensitive for this injury as well as in identifying other potential sites of pathology, and should be considered in the workup of persistent low back pain in young children. Level II, diagnostic study.

  12. ParsEval: parallel comparison and analysis of gene structure annotations

    Directory of Open Access Journals (Sweden)

    Standage Daniel S

    2012-08-01

    Full Text Available Abstract Background Accurate gene structure annotation is a fundamental but somewhat elusive goal of genome projects, as witnessed by the fact that (model genomes typically undergo several cycles of re-annotation. In many cases, it is not only different versions of annotations that need to be compared but also different sources of annotation of the same genome, derived from distinct gene prediction workflows. Such comparisons are of interest to annotation providers, prediction software developers, and end-users, who all need to assess what is common and what is different among distinct annotation sources. We developed ParsEval, a software application for pairwise comparison of sets of gene structure annotations. ParsEval calculates several statistics that highlight the similarities and differences between the two sets of annotations provided. These statistics are presented in an aggregate summary report, with additional details provided as individual reports specific to non-overlapping, gene-model-centric genomic loci. Genome browser styled graphics embedded in these reports help visualize the genomic context of the annotations. Output from ParsEval is both easily read and parsed, enabling systematic identification of problematic gene models for subsequent focused analysis. Results ParsEval is capable of analyzing annotations for large eukaryotic genomes on typical desktop or laptop hardware. In comparison to existing methods, ParsEval exhibits a considerable performance improvement, both in terms of runtime and memory consumption. Reports from ParsEval can provide relevant biological insights into the gene structure annotations being compared. Conclusions Implemented in C, ParsEval provides the quickest and most feature-rich solution for genome annotation comparison to date. The source code is freely available (under an ISC license at http://parseval.sourceforge.net/.

  13. uPA/uPAR system activation drives a glycolytic phenotype in melanoma cells.

    Science.gov (United States)

    Laurenzana, Anna; Chillà, Anastasia; Luciani, Cristina; Peppicelli, Silvia; Biagioni, Alessio; Bianchini, Francesca; Tenedini, Elena; Torre, Eugenio; Mocali, Alessandra; Calorini, Lido; Margheri, Francesca; Fibbi, Gabriella; Del Rosso, Mario

    2017-09-15

    In this manuscript, we show the involvement of the uPA/uPAR system in the regulation of aerobic glycolysis of melanoma cells. uPAR over-expression in human melanoma cells controls an invasive and glycolytic phenotype in normoxic conditions. uPAR down-regulation by siRNA or its uncoupling from integrins, and hence from integrin-linked tyrosine kinase receptors (IL-TKRs), by an antagonist peptide induced a striking inhibition of the PI3K/AKT/mTOR/HIF1α pathway, resulting into impairment of glucose uptake, decrease of several glycolytic enzymes and of PKM2, a checkpoint that controls metabolism of cancer cells. Further, binding of uPA to uPAR regulates expression of molecules that govern cell invasion, including extracellular matrix metallo-proteinases inducer (EMPPRIN) and enolase, a glycolytyc enzyme that also serves as a plasminogen receptor, thus providing a common denominator between tumor metabolism and phenotypic invasive features. Such effects depend on the α5β1-integrin-mediated uPAR connection with EGFR in melanoma cells with engagement of the PI3K-mTOR-HIFα pathway. HIF-1α trans-activates genes whose products mediate tumor invasion and glycolysis, thus providing the common denominator between melanoma metabolism and its invasive features. These findings unveil a unrecognized interaction between the invasion-related uPAR and IL-TKRs in the control of glycolysis and disclose a new pharmacological target (i.e., uPAR/IL-TKRs axis) for the therapy of melanoma. © 2017 UICC.

  14. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  15. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  16. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  17. CFD modelling of hydrogen stratification in enclosures: Model validation and application to PAR performance

    Energy Technology Data Exchange (ETDEWEB)

    Hoyes, J.R., E-mail: james.hoyes@hsl.gsi.gov.uk; Ivings, M.J.

    2016-12-15

    Highlights: • The ability of CFD to predict hydrogen stratification phenomena is investigated. • Contrary to expectation, simulations on tetrahedral meshes under-predict mixing. • Simulations on structured meshes give good agreement with experimental data. • CFD model used to investigate the effects of stratification on PAR performance. • Results show stratification can have a significant effect on PAR performance. - Abstract: Computational Fluid Dynamics (CFD) models are maturing into useful tools for supporting safety analyses. This paper investigates the capabilities of CFD models for predicting hydrogen stratification in a containment vessel using data from the NEA/OECD SETH2 MISTRA experiments. Further simulations are then carried out to illustrate the qualitative effects of hydrogen stratification on the performance of Passive Autocatalytic Recombiner (PAR) units. The MISTRA experiments have well-defined initial and boundary conditions which makes them well suited for use in a validation study. Results are presented for the sensitivity to mesh resolution and mesh type. Whilst the predictions are shown to be largely insensitive to the mesh resolution they are surprisingly sensitive to the mesh type. In particular, tetrahedral meshes are found to induce small unphysical convection currents that result in molecular diffusion and turbulent mixing being under-predicted. This behaviour is not unique to the CFD model used here (ANSYS CFX) and furthermore, it may affect simulations run on other non-aligned meshes (meshes that are not aligned perpendicular to gravity), including non-aligned structured meshes. Following existing best practice guidelines can help to identify potential unphysical predictions, but as an additional precaution consideration should be given to using gravity-aligned meshes for modelling stratified flows. CFD simulations of hydrogen recombination in the Becker Technologies THAI facility are presented with high and low PAR positions

  18. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  19. Lipid nanoparticles as delivery vehicles for the Parietaria judaica major allergen Par j 2.

    Science.gov (United States)

    Bondì, Maria Luisa; Montana, Giovanna; Craparo, Emanuela Fabiola; Di Gesù, Roberto; Giammona, Gaetano; Bonura, Angela; Colombo, Paolo

    2011-01-01

    Parietaria pollen is one of the major causes of allergic reaction in southern Europe, affecting about 30% of all allergic patients in this area. Specific immunotherapy is the only treatment able to modify the natural outcome of the disease by restoring a normal immunity against allergens. The preparation of allergen-solid lipid nanoparticles as delivery vehicles for therapeutic proteins, P. judaica major allergen Par j 2, was investigated. The Par j 2 allergen was expressed in a large amount in Escherichia coli and purified to homogeneity. Its immunological properties were studied by western blotting and enzyme-linked immunosorbent assay inhibition. Solid lipid nanoparticles were obtained by water-in-oil-in-water multiple emulsion method and characterized in terms of mean size and surface charge. These systems (approximately 250 nm diameter and negative surface charge) incorporated recombinant Par j 2 with 40% or greater efficiency. Moreover, the endotoxin level and anaphylactic activity of the empty solid lipid nanoparticles and recombinant Par j 2-loaded solid lipid nanoparticles were evaluated by looking at the overexpression of CD203c marker on human basophils. These results demonstrate that recombinant Par j 2-nanoparticles could be proposed as safe compositions for the development of new therapeutic dosage forms to cure allergic reactions.

  20. Valproate alters dopamine signaling in association with induction of Par-4 protein expression.

    Directory of Open Access Journals (Sweden)

    Saebom Lee

    Full Text Available Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA, a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC inhibitor activity, but the relationship between its efficacy as a mood stabilizer and HDAC inhibitory activity is unclear. Here we provide evidence that prostate apoptosis response-4 (Par-4, an intracellular binding partner of dopamine D2 receptors (DRD2, plays a role in mediating the effectiveness of VPA. We found that chronic VPA treatment enhanced the expression of Par-4 in cultured neurons and adult mouse brains. This Par-4 induction phenomenon occurred at the transcriptional level and was correlated with an increase in histone H3 and H4 acetylation of the Par-4 promoter regions. Furthermore, chronic VPA treatment potentiated the suppression of the cAMP signaling cascade upon dopamine stimulation, which was blocked by sulpiride treatment. These results indicate that VPA potentiates DRD2 activity by enhancing Par-4 expression via a chromatin remodeling mechanism.

  1. Participatory action research (PAR) in middle school: opportunities, constraints, and key processes.

    Science.gov (United States)

    Ozer, Emily J; Ritterman, Miranda L; Wanis, Maggie G

    2010-09-01

    Late childhood and early adolescence represent a critical transition in the developmental and academic trajectory of youth, a time in which there is an upsurge in academic disengagement and psychopathology. PAR projects that can promote youth's sense of meaningful engagement in school and a sense of efficacy and mattering can be particularly powerful given the challenges of this developmental stage. In the present study, we draw on data from our own collaborative implementation of PAR projects in secondary schools to consider two central questions: (1) How do features of middle school settings and the developmental characteristics of the youth promote or inhibit the processes, outcomes, and sustainability of the PAR endeavor? and (2) How can the broad principles and concepts of PAR be effectively translated into specific intervention activities in schools, both within and outside of the classroom? In particular, we discuss a participatory research project conducted with 6th and 7th graders at an urban middle school as a means of highlighting the opportunities, constraints, and lessons learned in our efforts to contribute to the high-quality implementation and evaluation of PAR in diverse urban public schools.

  2. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    Science.gov (United States)

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  3. Regulation of mature T lymphocyte proliferation and differentiation by Par-4

    Science.gov (United States)

    Lafuente, María José; Martin, Pilar; Garcia-Cao, Isabel; Diaz-Meco, María Teresa; Serrano, Manuel; Moscat, Jorge

    2003-01-01

    The genetic inactivation of the atypical protein kinase C (aPKC) inhibitor, Par-4, gives rise to increased NF-κB activation and decreased stimulation of JNK in embryo fibroblasts. Here we have characterized the immunological phenotype of the Par-4–/– mice and found that the loss of this gene leads to an increased proliferative response of peripheral T cells when challenged through the TCR. This is accompanied by a higher increase in cell cycle entry and inhibition of apoptosis, with enhanced IL-2 secretion but normal CD25 synthesis. Interestingly, the TCR-triggered activation of NF-κB was augmented and that of JNK was severely abrogated. Consistent with previous data from knock outs of different JNKs, NFATc1 activation and IL-4 secretion were augmented in the Par-4-deficient CD4+ T cells, suggesting that the loss of Par-4 drives T-cell differentiation towards a Th2 response. This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling. PMID:12970181

  4. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    Science.gov (United States)

    Bache, Michael; Bosco, Filippo G.; Brøgger, Anna L.; Frøhling, Kasper B.; Sonne Alstrøm, Tommy; Hwu, En-Te; Chen, Ching-Hsiu; Eugen-Olsen, Jesper; Hwang, Ing-Shouh; Boisen, Anja

    2013-11-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody-antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform.

  5. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  6. Protease-activated receptors (PARs) in cancer: Novel biased signaling and targets for therapy.

    Science.gov (United States)

    Bar-Shavit, R; Maoz, M; Kancharla, A; Jaber, M; Agranovich, D; Grisaru-Granovsky, S; Uziely, B

    2016-01-01

    Despite the fact that G protein-coupled receptors (GPCRs) mediate numerous physiological processes and represent targets for therapeutics for a vast array of diseases, their role in tumor biology is under appreciated. Protease-activated receptors (PARs) form a family which belongs to GPCR class A. PAR1&2 emerge with a central role in epithelial malignancies. Although the part of PAR1&2 in cancer is on the rise, their underlying signaling events are poorly understood. We review hereby past, present, and future cancer-associated PAR biology. Mainly, their role in physiological (placenta-cytotophobalst) and patho-physiological invasion processes. The identification and characterization of signal pleckstrin homology (PH)-domain-binding motifs established critical sites for breast cancer growth in PAR1&2. Among the proteins found to harbor important PH-domains and are involved in PAR biology are Akt/PKB as also Etk/Bmx and Vav3. A point mutation in PAR2, H349A, but not R352A, abrogated PH-protein association and is sufficient to markedly reduce PAR2-instigated breast tumor growth in vivo as also placental extravillous trophoblast (EVT) invasion in vitro is markedly reduced. Similarly, the PAR1 mutant hPar1-7A, which is unable to bind PH-domain, inhibits mammary tumors and EVT invasion, endowing these motifs with physiological significance and underscoring the importance of these previously unknown PAR1 and PAR2 PH-domain-binding motifs in both pathological and physiological invasion processes. Copyright © 2016 Elsevier Inc. All rights reserved.

  7. Causes de d?c?s des patients infect?s par le VIH dans le Centre tunisien

    OpenAIRE

    Chelli, Jih?ne; Bellazreg, Foued; Aouem, Abir; Hattab, Zouhour; Mesmia, H?la; Lasfar, Nadia Ben; Hachfi, Wissem; Masmoudi, Tasnim; Chakroun, Mohamed; Letaief, Amel

    2016-01-01

    La trith?rapie antir?trovirale a contribu? ? une baisse consid?rable de la mortalit? li?e au VIH. Les causes de d?c?s sont domin?es par les infections opportunistes dans les pays en voie de d?veloppement et par les maladies cardiovasculaires et les cancers dans les pays d?velopp?s. L?objectif ?tait de d?terminer les causes et les facteurs de risque de d?c?s des patients infect?s par le VIH dans le Centre Tunisien. Une ?tude transversale aupr?s des patients infect?s par le VIH ?g?s de plus de ...

  8. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  9. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270] Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  10. Endothelial progenitor cell-dependent angiogenesis requires localization of the full-length form of uPAR in caveolae.

    Science.gov (United States)

    Margheri, Francesca; Chillà, Anastasia; Laurenzana, Anna; Serratì, Simona; Mazzanti, Benedetta; Saccardi, Riccardo; Santosuosso, Michela; Danza, Giovanna; Sturli, Niccolò; Rosati, Fabiana; Magnelli, Lucia; Papucci, Laura; Calorini, Lido; Bianchini, Francesca; Del Rosso, Mario; Fibbi, Gabriella

    2011-09-29

    Endothelial urokinase-type plasminogen activator receptor (uPAR) is thought to provide a regulatory mechanism in angiogenesis. Here we studied the proangiogenic role of uPAR in endothelial colony-forming cells (ECFCs), a cell population identified in human umbilical blood that embodies all of the properties of an endothelial progenitor cell matched with a high proliferative rate. By using caveolae-disrupting agents and by caveolin-1 silencing, we have shown that the angiogenic properties of ECFCs depend on caveolae integrity and on the presence of full-length uPAR in such specialized membrane invaginations. Inhibition of uPAR expression by antisense oligonucleotides promoted caveolae disruption, suggesting that uPAR is an inducer of caveolae organization. Vascular endothelial growth factor (VEGF) promoted accumulation of uPAR in ECFC caveolae in its undegraded form. We also demonstrated that VEGF-dependent ERK phosphorylation required integrity of caveolae as well as caveolar uPAR expression. VEGF activity depends on inhibition of ECFC MMP12 production, which results in impairment of MMP12-dependent uPAR truncation. Further, MMP12 overexpression in ECFC inhibited vascularization in vitro and in vivo. Our data suggest that intratumor homing of ECFCs suitably engineered to overexpress MMP12 could have the chance to control uPAR-dependent activities required for tumor angiogenesis and malignant cells spreading.

  11. PAR3 and aPKC regulate Golgi organization through CLASP2 phosphorylation to generate cell polarity

    Science.gov (United States)

    Matsui, Toshinori; Watanabe, Takashi; Matsuzawa, Kenji; Kakeno, Mai; Okumura, Nobumasa; Sugiyama, Ikuko; Itoh, Norimichi; Kaibuchi, Kozo

    2015-01-01

    The organization of the Golgi apparatus is essential for cell polarization and its maintenance. The polarity regulator PAR complex (PAR3, PAR6, and aPKC) plays critical roles in several processes of cell polarization. However, how the PAR complex participates in regulating the organization of the Golgi remains largely unknown. Here we demonstrate the functional cross-talk of the PAR complex with CLASP2, which is a microtubule plus-end–tracking protein and is involved in organizing the Golgi ribbon. CLASP2 directly interacted with PAR3 and was phosphorylated by aPKC. In epithelial cells, knockdown of either PAR3 or aPKC induced the aberrant accumulation of CLASP2 at the trans-Golgi network (TGN) concomitantly with disruption of the Golgi ribbon organization. The expression of a CLASP2 mutant that inhibited the PAR3-CLASP2 interaction disrupted the organization of the Golgi ribbon. CLASP2 is known to localize to the TGN through its interaction with the TGN protein GCC185. This interaction was inhibited by the aPKC-mediated phosphorylation of CLASP2. Furthermore, the nonphosphorylatable mutant enhanced the colocalization of CLASP2 with GCC185, thereby perturbing the Golgi organization. On the basis of these observations, we propose that PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation. PMID:25518939

  12. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  13. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  14. Helicophyllaceae (Bryophyta, nova ocorrência para o Estado do Pará, Brasil Helicophyllaceae (Bryophyta, a new record to Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L. Lisboa

    2005-09-01

    Full Text Available Helicophyllaceae, família monotípica neotropical, é registrada pela primeira vez no Estado do Pará. Sua única espécie, Helicophyllum torquatum (Hook. Brid., registrada anteriormente no Estado do Amazonas e que recentemente havia sido excluída da lista de musgos amazônicos, é apresentada como nova ocorrência para toda a Amazônia brasileira.Helicophyllaceae, a monotypic family of Neotropics, is presented for the Pará State. Helicophyllum torquatum (Hook. Brid., the single species, was recorded for the Amazonas State, but recently was excluded of checklist of Amazonian mosses. H. torquatum is considered a new report for all Brazilian Amazônia.

  15. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects.

  16. Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    DEFF Research Database (Denmark)

    Hansen, Line; Unmack Larsen, Esben Kjær; Nielsen, Erik Holm

    2013-01-01

    patient prognosis shared by several cancers including breast, colorectal, and gastric cancers. Conjugation of a uPAR specific targeting peptide onto polyethylene glycol (PEG) coated USPIO nanoparticles by click chemistry resulted in a five times higher uptake in vitro in a uPAR positive cell line compared......Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are currently being used as a magnetic resonance imaging (MRI) contrast agent in vivo, mainly by their passive accumulation in tissues of interest. However, a higher specificity can ideally be achieved when the nanoparticles are targeted...... towards cell specific receptors and this may also facilitate specific drug delivery by an enhanced target-mediated endocytosis. We report efficient peptide-mediated targeting of magnetic nanoparticles to cells expressing the urokinase plasminogen activator receptor (uPAR), a surface biomarker for poor...

  17. Development of a semi-parametric PAR partitioning model for the contiguous US

    Science.gov (United States)

    Kathilankal, J. C.; O'Halloran, T. L.; Schmidt, A.; Hanson, C. V.; Law, B. E.

    2014-03-01

    A semi-parametric PAR diffuse radiation model was developed using commonly measured climatic variables from 44 site-years of data from 9 AmeriFlux sites. The model has a logistic form and improves upon previous efforts, using a larger data set and physically viable climate variables as predictors, including relative humidity, clearness index, surface albedo, and solar elevation angle. Model performance was evaluated by comparison with a simple cubic polynomial model developed for the PAR spectral range. The logistic model outperformed the polynomial model with an improved coefficient of determination and slope relative to measured data (logistic: R2 = 0.85; slope = 0.86; cubic: R2 = 0.82; slope = 0.83), making this the most robust PAR-partitioning model for the US subcontinent currently available.

  18. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  19. The PARS sequence increase the efficiency of stable Pichia pastoris transformation.

    Science.gov (United States)

    Madsen, Claus Krogh; Vismans, Gilles; Brinch-Pedersen, Henrik

    2016-10-01

    The methylotrophic yeast Pichia pastoris is a popular host for recombinant expression of proteins. Plasmids containing the Pichia autonomously replicating sequence (PARS) transform P. pastoris with higher efficiency than linear DNA equipped with termini designed for homologous recombination. Moreover, PARS containing constructs provide higher protein yields. Unfortunately, these autonomous plasmids are inherently unstable and the preferred method of P. pastoris transformation is therefore stable integration in the genome by homologous recombination. In the present study we report that a novel combination of PARS and linearization of plasmids for P. pastoris transformation serves to significantly increase the transformation efficiency. Moreover, it is demonstrated that the constructs do not re-circularize but integrate stably into the P. pastoris genome. Copyright © 2016 Elsevier B.V. All rights reserved.

  20. Bufo & Spallanzani e a paródia pós-modernista

    Directory of Open Access Journals (Sweden)

    Saulo Brandão

    2016-02-01

    Full Text Available O presente trabalho tem por objetivo investigar as considerações acerca da paródia e sua implicação na linha teórica pós-modernista, partindo das análises de Fredric Jameson e Linda Hutcheon, quando conceituando pastiche. Desse modo, nos propomos a fazer uma análise das paródias no romance Bufo & Spallanzani, de Rubem Fonseca, a partir da leitura de Ana Cristina T. de B. Carvalho (2013 que corrobora para sonegar a proposta de Jameson. Desse modo, procuraremos, no emaranhado de citações do romance, que remetem aos mais diversos campos da cultura, elementos que qualifiquem a característica paródica do romance, tendo por embasamento a contraproposta feita por Linda Hutcheon.

  1. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    OpenAIRE

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; A. Abbassi; Belmahi, A.M.

    2011-01-01

    Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondai...

  2. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  3. Toxina botulínica y fisioterapia en la parálisis cerebral infantil

    OpenAIRE

    Camilieri Rumbau, María Mercé

    2006-01-01

    Introducción: La parálisis cerebral es la causa más común de espasticidad en niños y la toxina botulínica A es un opción para su el tratamiento, ya que produce una parálisis local al ser inyectada en un músculo. Objetivo: Comprobar la eficacia de la aplicación de toxina botulínica y fisioterapia en la parálisis cerebral infantil. Material y método: Se ha realizado una búsqueda en diversas bases de datos electrónicas como son Freejournals, Doyma, Medline, Google y revistas de neuro...

  4. Paraplégie compliquant une plaie abdominale antérieure par arme blanche

    Science.gov (United States)

    Elahmadi, Brahim; Awab, Almahdi; El Moussaoui, Rachid; El Hijri, Ahmed; Azzouzi, Abderrahim; Alilou, Mustapha

    2015-01-01

    Les traumatismes médullaires sont des complications rares des plaies abdominales antérieures par arme blanche. Son diagnostic est difficile parfois retardé. L'imagerie par résonance magnétique reste l'examen de choix. Le traitement dépend du tableau clinique et de la gravité de la souffrance médullaire. Le pronostic est corrélé à l’étendue et à la nature de la lésion médullaire. Nous rapportons un cas exceptionnel d'un traumatisme médullaire chez une patiente victime d'une plaie abdominale antérieure par arme blanche. PMID:25995808

  5. Relación entre la Deseabilidad Social y los parámetros del Modelo Logístico de tres parámetros

    Directory of Open Access Journals (Sweden)

    Facundo Abal

    2015-05-01

    Full Text Available El objetivo de este trabajo es estudiar la relación de los parámetros a , b y c del modelo logístico de tres parámetros y la tendencia de los individuos a atribuirse a sí mismo cualidades socialmente deseables. Participaron 1592 personas que respondieron las escalas Perseverancia y Distorsión del Big Five Questionnaire (BFQ. Se aplicó el ML3p a los ítems de perseverancia mediante el programa MULTILOG. Previamente se debieron eliminar 3 reactivos para cumplir con la condición de unidimensionalidad requerida por el modelo. Como la escala Likert de los ítems de perseverancia tiene 5 de alternativas se contemplaron diferentes procedimientos para establecer 4 condiciones de dicotomización de los datos. Los parámetros de los ítems se estimaron el procedimiento de Máxima Verosimilitud Marginal a Posteriori. El ajuste del ML3p fue adecuado para los 9 ítems analizados. Considerando las diferentes condiciones de dicotomización se identificaron entre 3 y 5 ítems de cuya respuesta clave se asoció a mayores niveles de Distorsión. Sin embargo, los resultados obtenidos no permiten concluir que la respuesta influida por la deseabilidad social repercuta sobre alguno de los parámetros estudiados. Se discuten las limitaciones del presente estudio y se comentan otras líneas de investigación que pueden guiar a futuros estudios.

  6. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  7. Expression of JAM-A, AF-6, PAR-3 and PAR-6 during the assembly and remodeling of RPE tight junctions.

    Science.gov (United States)

    Luo, Yan; Fukuhara, Masayuki; Weitzman, Matthew; Rizzolo, Lawrence J

    2006-09-19

    The tight junctions of the endothelial and epithelial regions of the blood-brain barrier are regulated by interactions with the neighboring tissue. We examined how the neural retina regulates the assembly of tight junctions in the retinal pigment epithelium (RPE). The proteins JAM-A, AF-6, PAR-3 and PAR-6 have been implicated in the assembly of other epithelial tight junctions. Using chick embryos and primary cell culture, we examined gene expression of these proteins during embryonic development, and whether retinal secretions regulate their expression. Three highly conserved RNA splice sites of AF-6 were identified in chick ocular tissues, but only two were expressed in RPE. JAM-A and AF-6 were expressed at relatively high levels early in development when adherens junctions form, but before tight junctions form. Expression of JAM-A and the AF-6 isoforms actually decreased when tight junctions were forming and expanding. The expression of PAR-3 and PAR-6 was constant. Despite the expression of these proteins in vitro (along with claudins, occludin, ZO-1 and ZO-2), the tight junctional networks that form were discontinuous (Rahner, C., Fukuhara, M., Peng, S., Kojima, S., Rizzolo, L.J., 2004. The apical and basal environments of the retinal pigment epithelium regulate the maturation of tight junctions during development. J. Cell Sci. 117, 3307-3318). The expression of these assembly proteins was unaffected by a retinal conditioned medium that induced the completion of tight junction formation. These data indicate that the early expression of the assembly proteins corresponds to the initial establishment of the adherens and tight junctions, but secretory products of the neural retina must induce the expression of additional proteins to complete the maturation process.

  8. Analysis of some sepsis markers: C-reactive protein, Procalcitonin, Osteopontin and suPAR

    Directory of Open Access Journals (Sweden)

    Ilaria Crespi

    2010-09-01

    Full Text Available Sepsis appears to be due to an uncontrolled pro and anti-inflammatory response leading to organ dysfunction until shock and death.Accuracy of diagnosis and appropriate treatment affect the outcome. Aim of the study was to investigate if the levels of Osteopontin (OPN and Soluble Urokinase-type Plasminoge Activator Receptor (suPAR might be early markers of sepsis and if these markers play a role in predicting the progression to septic shock. Methods:The levels of OPN, suPAR, C-reactive protein (CRP and procalcitonin (PCT were measured in patients at higher risk of infection. The samples were collected from the day of admission for the following fifteenth day. During recovery Sistemic Inflammatory Response Syndrome (SIRS criteria, blood chemistry data, blood gas- analysis, lactate and diuresis were collected. Microbiological culture were performed according to the clinical condition. Results: 29 patients were enrolled in the study, including 14 subjects with positive blood cultures.The values of OPN, PCT, suPAR and CRP were significantly increased in patients with positive blood cultures than those with negative blood cultures.Analysing changes of the levels of OPN, suPAR, PCT and CRP in patients with septic shock, the values of OPN increased in advance to the clinical diagnosis of septic shock, while the values of suPAR and PCT slight delay compared to those OPN.The levels of CRP were independent from the onset of septic shock state. Conclusions: These preliminary data suggest that Osteopontin and suPAR can be used as early markers of sepsis and might be useful in monitoring of septic outcome to predict a possible evolution to septic shock.

  9. Characterization of a dominant antigenic determinant of Par o I encoded by recombinant DNA.

    Science.gov (United States)

    Scotto d'Abusco, A S; De Santo, C; Menna, T; Coscia, M R; Oreste, U; Geller-Bernstein, C; Ruffilli, A

    1996-02-01

    The pollens from Parietaria judaica and Parietaria officinalis are a major cause of pollinosis in Europe. Par o I (13.5 kDa) and Par j I (12 kDa), the major allergens from these species, are highly crossreactive. We have immunoscreened a P. judaica pollen cDNA expression library with a rabbit antiserum specific for Par j I and with a serum pool from allergic patients. An immunopositive clone containing a 26 bp insert was further characterized. The insert sequence was determined and the beta-galactosidase fusion protein was partially purified by electroelution from sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) gels. This fusion protein specifically and extensively inhibited Par o I and Par j I binding of a rabbit antiserum and of a serum pool obtained from allergic patients. The antifusion-protein antiserum obtained in a rabbit (anti 6a) specifically precipitated radioiodinated purified Par o I in the double antibody radioimmunoassay (DARIA) and competed with antibodies of sera from allergic patients for the binding to Parietaria pollen extract allergens by enzyme linked immunosorbent assay (ELISA). We investigated the prevalence of antibody response towards the 6a epitope in patients naturally sensitized to Parietaria. The presence of 6a specific IgE antibodies was assessed in the sera of 33 patients using inhibition assays. All sera had antibodies with this specificity: the extensive percentage of inhibition reached suggested that they dominated individual ab response. In conclusion, the antibody response induced by natural exposure to the pollen of Parietaria appears to be higly focused on a single linear antigenic determinant of the major allergens which may play a relevant role in the development of clinical allergy. This report is, to our knowledge, the first description of a dominant linear epitope of a major allergen.

  10. Linking the fPAR, forest albedo and biomass in the northern biomes of Europe

    Science.gov (United States)

    Lukeš, Petr; Stenberg, Pauline; Manninen, Terhikki; Rautiainen, Miina; Mõttus, Matti

    2014-05-01

    Land surface albedo and the fraction of photosynthetically active radiation (fPAR) absorbed by plant canopies are two of the essential climate variables controlling the planetary radiative energy budget. Albedo is directly related to the energy exchange between land and the atmosphere as it is the reflectivity of the surface - the higher the albedo, the more incoming solar radiation is reflected and the less absorbed by the surface. The fPAR is related to plant productivity, quantifying the amount of absorbed light available for photosynthesis. It is a key parameter in the modelling of net primary production (NPP) of terrestrial ecosystems. Global climate scenarios are very sensitive to albedo and fPAR estimates, and thus, the effect of changes in canopy structure and density (biomass) on these two variables needs to be quantified reliably. Both parameters are routinely retrieved from current Earth Observation sensors using specialized algorithms. To date, these satellite products have not been linked to extensive forest inventory data sets due to the lack of ground reference data. Data availability for Finland has significantly improved in December 2012, when National Forest Inventory (NFI) data became freely available to the public. The dataset covers the geographical area of Finland (26.1 million hectares) at a spatial resolution of 20 meters including several forest structural variables. In this study, we use the NFI data to study the links between forest albedo, fPAR and forest structure and density during the green vegetation season. More specifically, we investigated the seasonal trends in fPAR and albedo of different spectral regions of northern forests. Empirical relationships between forest albedo, fPAR and total aboveground biomass were established for selected days within the vegetation growing period and across a latitudinal transect of Finland.

  11. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  12. Identification of marker genes for pars tuberalis morphogenesis in chick embryo: expression of Cytokine-like 1 and Gap junction protein alpha 5 in pars tuberalis.

    Science.gov (United States)

    Aizawa, Sayaka; Higaki, Yuriko; Dudaui, Amrita; Nagasaka, Mai; Takahashi, Sumio; Sakata, Ichiro; Sakai, Takafumi

    2016-12-01

    The adenohypophysis is formed from the oral ectoderm and consists of the pars distalis (PD), pars intermedia, and pars tuberalis (PT). The mechanisms of PD development have been extensively studied, and the cellular differentiation of the PD is well understood. However, the morphogenesis and differentiation of the PT are still unclear, and the genes expressed during PT development remain largely unknown. We have explored genes specifically expressed in the PT during embryonic development and analyzed their spatiotemporal expression patterns. Microarray analysis of laser-captured PT and PD tissues obtained from chick embryos on embryonic day 10 (E10.0) has shown high expression of Cytokine-like 1 (CYTL1) and Gap junction protein alpha 5 (GJA5) genes in the PT. Detailed analysis of these spatiotemporal expression patterns during chick embryo development by in situ hybridization has revealed that CYTL1 mRNA first appears in the lateral head ectoderm and ventral head ectoderm at E1.5. The expression of CYTL1 moves into Rathke's pouch at E2.5 and is then localized in the PT primordium where it is continuously expressed until E12.0. GJA5 mRNA is transiently detected in the PT primordium from E6.0 to E12.0, whereas its expression is not detected in the PD during development. Thus, these genes might be involved in the regulation mechanisms of PT development and could be useful markers for PT development.

  13. Parásitos de Fasciola hepática intracoledociano

    OpenAIRE

    MILLÁN A,MARCELO; WAGENKNECHT S,RAUL; CARDENAS P,ALEX; CARRASCO L,CRISTIAN

    2008-01-01

    La fasciolasis es una enfermedad parasitaria producida por el tremátodo digeneo Fasciola hepática. Durante la fase crónica de la enfermedad los parásitos pueden entran en los conductos biliares, y ser causa de ictericia obstructiva, colangitis, pancreatitis y otras complicaciones. Se presenta el caso clínico de una paciente intervenida por sospecha de colelitiasis y colédocolitiasis, a la cual durante la exploración coledociana intraoperatoria le fueron extraídos múltiples parásitos adultos d...

  14. Miasis oral en un paciente con parálisis cerebral: Reporte de un caso

    OpenAIRE

    Hernán Arango Fernández; Martha Rebolledo Cobos; Marisol Sánchez Molina; Pablo Roa Rojas; Pedro Felipe Méndez Malagón

    2016-01-01

    La Miasis Oral es una infección parasitaria ocasionada por larvas de mosca que pueden afectar tejido vivo o necrótico, etiológicamente se asocia a deficiente higiene oral, lesiones supurativas, alcoholismo, pacientes seniles, parálisis cerebral, entre otras condiciones que predisponen al depósito de estas larvas. El presente caso evidencia una paciente femenina de 22 años de edad con diagnóstico de parálisis cerebral y desnutrición severa, la cual es llevada por acudiente presentando tumefacc...

  15. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Charles Huamaní; Arturo Reyes; Percy Mayta-Tristán; Raúl Timana; Abel Salazar; David Sánchez; Hugo Pérez

    2006-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  16. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Huamaní, Charles; Universidad Nacional Mayor de San Marcos. Lima, Perú; Sociedad Científica de San Fernando. Lima, Perú; Sociedad Científica Médico Estudiantil Peruana. Lima, Perú; Reyes, Arturo; Instituto Especializado en Ciencias Neurológicas Oscar Trelles Montes. Lima, Perú; Mayta-Tristán, Percy; Instituto Nacional de Salud. Lima, Perú; Timana, Raúl; Universidad Nacional Mayor de San Marcos. Lima, Perú; Sociedad Científica de San Fernando. Lima, Perú; Salazar, Abel; Universidad Nacional Mayor de San Marcos. Lima, Perú; Sociedad Científica de San Fernando. Lima, Perú; Sánchez, David; Universidad Nacional Mayor de San Marcos. Lima, Perú; Sociedad Científica de San Fernando. Lima, Perú; Pérez, Hugo; Universidad Nacional Mayor de San Marcos. Lima, Perú; Sociedad Científica de San Fernando. Lima, Perú

    2013-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  17. Fait marquant : discussions sur les données ouvertes entamées par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    14 avr. 2016 ... La santé dans les Caraïbes Contrer l'obésité par la diversité des aliments locaux. Dans les Caraïbes, la conjugaison de l'augmentation des importations d'aliments transformés et de la faible consommation d'aliments sains comme les. Voir davantageLa santé dans les Caraïbes Contrer l'obésité par la ...

  18. Le Sycoscan : un système d'inspection des conteneurs par balayage radioscopique

    CERN Multimedia

    Krystal Production

    1997-01-01

    La société Europ Scan, le port autonome du Havre et les douanes françaises ont conçu un système de contrôle par rayons X qui permet d’étudier par radiographie le contenu d'un chargement. Les conteneurs sont ainsi vérifiés sans être déchargés ou ouverts. On utilise des faisceaux de rayons X de faible énergie couplés à des détecteurs ultrasensibles inspirés de la chambre à fils de Georges Charpak.

  19. Les plantes des galeries forestières à usage traditionnel par les ...

    African Journals Online (AJOL)

    Des enquêtes ethnobotaniques ont été réalisées de 2006 à 2010 dans les provinces de la Comoé et du Kénédougou localisées dans l'Ouest du Burkina Faso. Ces provinces sont majoritairement peuplées par l'ethnie Sénoufo. Elles sont caractérisées par un climat relativement humide, une présence de rivières ...

  20. Freehand technique for C2 pedicle and pars screw placement: safe or not?

    Science.gov (United States)

    Punyarat, Prachya; Riew, K Daniel; Klawson, Benjamin T; Peters, Colleen; Lertudomphonwanit, Thamrong; Buchowski, Jacob M

    2017-11-16

    During placement of C2 pedicle and pars screws, intraoperative fluoroscopy is used so that neurovascular complications can be avoided, and screws can be placed in the proper position. However, this method is time consuming and increases radiation exposure. Furthermore, it does not guarantee completely safe and accurate screw placement. To evaluate the safety of the C2 pedicle and pars screw placement without fluoroscopic or other guidance methods. Retrospective comparative study. One hundred and ninety-eight patients who underwent placement of C2 pedicle or pars screws without any intraoperative radiographic guidance were included. Medical records and postoperative CT scans were evaluated. Clinical data were reviewed for intraoperative and postoperative complications. Accuracy of screw placement was evaluated with post-op CT scans using a previously published cortical-breach grading system (described by location and percentage of screw diameter over cortical edge (0 = none; grade I = pars screws were inserted by two experienced surgeons. There were no cases of CSF leakage and no neurovascular complications during screw placement. Postoperative CT scans were available for 76 patients, which included 52 pedicle and 87 pars screws. For cases with C2 pedicle screws, there were 12 breaches (23%); these included 10 screws with a grade I breach (19%), 1 screw with a grade II breach (2%), and 1 screw with a grade IV breach (2%). Lateral breaches occurred in 7 screws (13%), inferior breaches in 3 (6%), and superior breaches in 2 (4%). For cases with C2 pars screws, there were 10 breaches (11%); these included 6 screws with a grade I breach (7%), 2 screws with a grade II breach (2%), and 2 screws with a grade IV breach (2%). Medial breaches were found in 4 (5%), lateral breaches in 2 (2%), inferior breaches in 2 (2%), and superior breaches in 2 (2%). 2 of the cases with superior breaches (1 for pedicle and 1 for pars) experienced occipital neuralgia months after surgery

  1. Tratamiento exitoso de un hemangioma de parótida con propranolol

    OpenAIRE

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    Los hemangiomas infantiles son los tumores vasculares benignos más frecuentes en la infancia, que ocurren mayormente en los pacientes pretérmino, en un 80 % afectan cabeza y cuello, y en algunos pacientes provocan serias complicaciones para la vida. El hemangioma de parótida es una forma clínica de presentación en la que suele verse un período proliferativo prolongado con lenta involución. Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente supe...

  2. F-actin-like filaments formed by plasmid segregation protein ParM

    DEFF Research Database (Denmark)

    van den Ent, Fusinita; Møller-Jensen, Jakob; Amos, Linda A.

    2002-01-01

    It was the general belief that DNA partitioning in prokaryotes is independent of a cytoskeletal structure, which in eukaryotic cells is indispensable for DNA segregation. Recently, however, immunofluorescence microscopy revealed highly dynamic, filamentous structures along the longitudinal axis...... of Escherichia coli formed by ParM, a plasmid-encoded protein required for accurate segregation of low-copy-number plasmid R1. We show here that ParM polymerizes into double helical protofilaments with a longitudinal repeat similar to filamentous actin (F-actin) and MreB filaments that maintain the cell shape...

  3. Prise en charge des péritonites par perforation d'ulcères gastro ...

    African Journals Online (AJOL)

    Le but de cette étude a été de décrire la prise en charge des péritonites aiguës généralisées par perforation d'ulcère gastrique ou duodénal et d'évaluer le bénéfice du drainage abdominal. Nous avons réalisé une étude transversale sur 3 ans. Elle a inclus 129 patients opérés pour péritonites par perforation gastrique ou ...

  4. Neuropathie optique bilatérale par intoxication aigue au méthanol ...

    African Journals Online (AJOL)

    La consommation d'alcool frelaté, contenant du méthanol, est un phénomène de société au Cameroun. Nous rapportons deux cas d'intoxication cécitante au méthanol dont l'évolution a été marquée pour l'un par l'installation d'une cécité irréversible et pour l'autre par une récupération partielle de l'acuité visuelle. Ces cas ...

  5. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    (intact/cleaved forms)—provides independent additional clinical information to that contributed by PSA, Gleason score, and other relevant pathological and clinical parameters. In this respect, non-invasive molecular imaging by positron emission tomography (PET) offers a very attractive technology platform......, which can provide the required quantitative information on the uPAR expression profile, without the need for invasive procedures and the risk of missing the target due to tumor heterogeneity. These observations support non-invasive PET imaging of uPAR in PC as a clinically relevant diagnostic...

  6. Films minces de dioxyde de titane déposés sur titane par mocvd : microstructure et biocomptabilité

    OpenAIRE

    Jacota Popescu, Simona Andreia

    2008-01-01

    Des films de TiO2 variant par le teneur relative en anatase et en rutile, par la rugosité, par la mouillabilité, par la morphologie de section transverse ont été déposés sur des plaquettes de titane par MOCVD à basse pression. Du titane oxydé par anodisation ou par explosion à l'air a aussi été préparé. La capacité des dépôts à protéger le titane contre la corrosion par un fluide biologique simulé s'est avérée supérieure à celle de l'oxyde naturel. Le comportement des fibroblastes et d'ostéob...

  7. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.

    Science.gov (United States)

    Tull, Samantha P; Bevins, Anne; Kuravi, Sahithi Jyothsna; Satchell, Simon C; Al-Ani, Bahjat; Young, Stephen P; Harper, Lorraine; Williams, Julie M; Rainger, George Ed; Savage, Caroline O S

    2012-01-01

    Neutrophil proteases, proteinase-3 (PR3) and elastase play key roles in glomerular endothelial cell (GEC) injury during glomerulonephritis. Endothelial protease-activated receptors (PARs) are potential serine protease targets in glomerulonephritis. We investigated whether PAR1/2 are required for alterations in GEC phenotype that are mediated by PR3 or elastase during active glomerulonephritis. Endothelial PARs were assessed by flow cytometry. Thrombin, trypsin and agonist peptides for PAR1 and PAR2, TFLLR-NH(2) and SLIGKV-NH(2,) respectively, were used to assess alterations in PAR activation induced by PR3 or elastase. Endothelial von Willebrand Factor (vWF)release and calcium signaling were used as PAR activation markers. Both PR3 and elastase induced endothelial vWF release, with elastase inducing the highest response. PAR1 peptide induced GEC vWF release to the same extent as PR3. However, knockdown of PARs by small interfering RNA showed that neither PAR1 nor PAR2 activation caused PR3 or elastase-mediated vWF release. Both proteases interacted with and disarmed surface GEC PAR1, but there was no detectable interaction with cellular PAR2. Neither protease induced a calcium response in GEC. Therefore, PAR signaling and serine protease-induced alterations in endothelial function modulate glomerular inflammation via parallel but independent pathways.

  8. PR3 and elastase alter PAR1 signaling and trigger vWF release via a calcium-independent mechanism from glomerular endothelial cells.

    Directory of Open Access Journals (Sweden)

    Samantha P Tull

    Full Text Available Neutrophil proteases, proteinase-3 (PR3 and elastase play key roles in glomerular endothelial cell (GEC injury during glomerulonephritis. Endothelial protease-activated receptors (PARs are potential serine protease targets in glomerulonephritis. We investigated whether PAR1/2 are required for alterations in GEC phenotype that are mediated by PR3 or elastase during active glomerulonephritis. Endothelial PARs were assessed by flow cytometry. Thrombin, trypsin and agonist peptides for PAR1 and PAR2, TFLLR-NH(2 and SLIGKV-NH(2, respectively, were used to assess alterations in PAR activation induced by PR3 or elastase. Endothelial von Willebrand Factor (vWFrelease and calcium signaling were used as PAR activation markers. Both PR3 and elastase induced endothelial vWF release, with elastase inducing the highest response. PAR1 peptide induced GEC vWF release to the same extent as PR3. However, knockdown of PARs by small interfering RNA showed that neither PAR1 nor PAR2 activation caused PR3 or elastase-mediated vWF release. Both proteases interacted with and disarmed surface GEC PAR1, but there was no detectable interaction with cellular PAR2. Neither protease induced a calcium response in GEC. Therefore, PAR signaling and serine protease-induced alterations in endothelial function modulate glomerular inflammation via parallel but independent pathways.

  9. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  10. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  11. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  12. Digestive ripening: a synthetic method par excellence for core–shell ...

    Indian Academy of Sciences (India)

    Digestive ripening: a synthetic method par excellence for core–shell, alloy, and composite nanostructured materials. SRILAKSHMI P BHASKAR and BALAJI R JAGIRDAR. ∗. Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India e-mail: jagirdar@ipc.iisc.ernet.in. Abstract.

  13. ParA encoded on chromosome II of Deinococcus radiodurans binds ...

    Indian Academy of Sciences (India)

    2013-07-22

    Jul 22, 2013 ... detected using NBT/BCIP (Roche Biochemical) colour reagent using the manufacturer's protocol. 2.6 Measurements of ATPase and GTPase activities. ATPase activity of recombinant ParA2 was checked using a modified protocol as described in (Kota et al. 2010). In brief, the increasing concentrations of ...

  14. Ambroise Paré (1510-1590)--Traek af kirurgfagets historie og dets medi- kamentelle aspekter

    DEFF Research Database (Denmark)

    Norn, Svend; Permin, Henrik; Kruse, Poul R

    2010-01-01

    the painful practise of cautery to stop bleeding and used ligatures and dressings instead. A multitude of subjects were included in his writings such as military surgery, aneurysm, hernia, obstetrics and plague, and through his techniques he guided the development of the gentle art of surgery. Paré became...

  15. Tuberculosis prevalence and risk factors for water buffalo in Pará, Brazil.

    Science.gov (United States)

    Barbosa, José D; da Silva, Jenevaldo B; Rangel, Charles P; da Fonseca, Adivaldo H; Silva, Natália S; Bomjardim, Henrique A; Freitas, Nayra F Q R

    2014-03-01

    The prevalence of and possible risk factors for tuberculosis were studied in water buffalo from Pará, Brazil. In this study, 3,917 pregnant and nonpregnant female Murrah and Mediterranean buffaloes were studied; 2,089 originated from Marajó Island, and 1,108 were from the mainland. The comparative cervical tuberculin test was used as a diagnostic test for tuberculosis in these animals. The prevalence of positive buffaloes was 3.5 % (100/2,809) on Marajó Island and 7.2 % (80/1,108) on the mainland. The municipalities with the highest tuberculosis prevalence rates in animals were Ipixuna do Pará (10.1 %), Marapanim (9.8 %), Chaves (9.4 %), Paragominas (8.6 %), and Cachoeira do Arari (6.7 %). The tuberculosis prevalence was not significantly different between the Murrah (4.3 %) and Mediterranean (4.8 %) breeds or between pregnant (5 %) and nonpregnant (4.3 %) buffaloes. Tuberculosis was detected in water buffaloes from Pará, Brazil; the mainland buffalo exhibited the highest tuberculosis prevalence. These results indicate that this disease is dangerous to public health and buffalo farming in Pará.

  16. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  17. Innate and adaptive immune responses to the major Parietaria allergen Par j 1 in healthy subjects.

    Science.gov (United States)

    Bonura, A; Quaratino, S; Gervasi, F; Melis, M R; Di Sano, C; Colombo, P

    2013-07-01

    In this study we wanted to analyse the pattern of the immune response to the Parietaria major allergen Par j 1 in freshly purified peripheral blood mononuclear cell (PBMC) from healthy subjects. We observed that Par j 1 was capable of inducing IFN-γ production by CD3⁻ and CD16⁺/CD56⁺ cells exclusively in healthy individuals. Furthermore, a multiparametric analysis allowed us a better definition of two IFN-γ-Par j 1 specific populations (IFN-γ(dim) and IFN-γ(high)) characterized by the presence of different proportions of NKT and NK cells. We also identified the concomitant presence of a subset of IL-10⁺ NK cells. Moreover, CFSE staining showed that the Par j 1 preferentially induced the proliferation of CD3⁻/CD56⁺/CD335⁺ cells. Finally, a subset of CD4⁺/CD25⁺/FoxP3⁺/IL-10⁻ T cells was identified. The result of this pilot study suggest that during a tolerogenic response, the major allergen of the Parietaria pollen works as an activator of both the innate and the adaptive human immune system. Copyright © 2012 Elsevier GmbH. All rights reserved.

  18. Granulome conjonctival suite à un traumatisme par épine végétale ...

    African Journals Online (AJOL)

    Granulome conjonctival suite à un traumatisme par épine végétale négligé: à propos d'un cas. Taha Elghazi, Amine Eljai, Maryama Elkaddoumi, Omar Lazrek, Sofia Hassani Saoudi, Taib Belkbir, Abdellah Amazouzi, Lalla Ouafae Cherkaoui, Rajae Daoudi ...

  19. Parásitos de animales silvestres en cautiverio en Lima, Perú

    Directory of Open Access Journals (Sweden)

    Lily Arrojo

    2013-06-01

    Full Text Available Los parásitos de los animales silvestres en cautiverio peruanos se registran aquí. La mayoría de las especies son nematodos. Dos especies son al patógeno de host: Prosthenorchois elegans y Strongyloides sp.

  20. Compression robuste du signal EMG par la transformee avec lec B ...

    African Journals Online (AJOL)

    Compression robuste du signal EMG par la transformee avec lec B-splines. PN Eloundou, P Ele, E Tonye. Abstract. No Abstract. Journal of the Cameroon Academy of Sciences Vol. 6 (3) 2006: pp. 195-206. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT.

  1. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas Berend; Marott, Jacob Louis

    2013-01-01

    BACKGROUND: Low-grade inflammation is a marker for cardiovascular disease (CVD). The inflammatory biomarkers C-reactive protein (CRP) and soluble urokinase plasminogen activator receptor (suPAR) independently predict CVD. We tested the hypothesis that these biomarkers reflect different aspects...

  2. 99 Modélisation de la pollution par les nitrates de la nappe de ...

    African Journals Online (AJOL)

    AKA BOKO

    Modélisation de la pollution par les nitrates de la nappe de. Berrechid, au Maroc. Karima EL BOUQDAOUI1*, Mostafa AACHIB2, Mohammed BLAGHEN1 et. Sanaa KHOLTEI3. 1Université Hassan II, Faculté des Sciences, Département biologie, Ain Chock,. B.P. 5366, Maârif, Casablanca, Maroc. 2 Ecole Hassania des ...

  3. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    Determining the quantum (both annual maxima and minima) and the temporal variation in the leaf area index (LAI), and the fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use ...

  4. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  5. Development of a par-boiled rice solar dryer | Abubakar | Bayero ...

    African Journals Online (AJOL)

    Energy is required in various forms to do useful work and necessary for the continual improvement in the standard of any society. This study presents the development of a par-boiled batch type rice solar dryer using an indirect mode natural convection solar energy. The dryer was designed and constructed to provide easier, ...

  6. ACUTE INTRAOPERATIVE SUPRACHOROIDAL HEMORRHAGE DURING SMALL-GAUGE PARS PLANA VITRECTOMY.

    Science.gov (United States)

    Sukpen, Intira; Stewart, Jay M

    2017-11-16

    To report the intraoperative occurrence of acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy. A review of a surgical patient who developed acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia. A 32-year-old obese woman with proliferative diabetic retinopathy and traction retinal detachment in the left eye who developed intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia while doing endolaser under air infusion. The pressure was immediately elevated to stabilize the hemorrhage without sclerotomy creation, and then gas (14% C3F8) was injected, with subsequent face-down positioning. The patient subsequently developed proliferative vitreoretinopathy, requiring additional surgery. The final visual acuity at 14-month follow-up was hand motions with a reattached retina in the left eye. Valsalva-induced suprachoroidal hemorrhage during pars plana vitrectomy under general anesthesia may result in sight-threatening visual consequences. Current small-gauge vitrectomy techniques using valved cannulas may allow for better intraoperative management of this complication through control of the intraocular pressure in a closed system.

  7. Participation and Participatory Action Research (PAR) in Environmental Education Processes: For What Are People Empowered?

    Science.gov (United States)

    Le Grange, Lesley

    2009-01-01

    Participatory action research (PAR) derived from anti-colonial struggles in the third world in the 1960s. Traditionally it has been a method of the margins because of its commitment to linking social justice to research. Because of its counter-hegemonic tendency it has had great appeal among environmental educators advocating a socially critical…

  8. Over de musculatuur van de pars intramularis tubae fallopii en haar functionele betekenis.

    NARCIS (Netherlands)

    Vasen, Ludwig Christiaan Leon Marie

    1959-01-01

    Frequent attempts have been made to discover in the region of the pars intramuralis tubae a sphinctermechanism, which might impede or even prevent the passage of noxious material from the lumen of the uterus to the abdominal cavity. Considerable time ago, anatomical structures were observed in

  9. The Utility of Clinicians Ratings of Anxiety Using the Pediatric Anxiety Rating Scale (PARS)

    Science.gov (United States)

    Ginsburg, Golda S.; Keeton, Courtney P.; Drazdowski, Tess K.; Riddle, Mark A.

    2011-01-01

    Clinician ratings of anxiety hold the promise of clarifying discrepancies often found between child and parent reports of anxiety. The Pediatric Anxiety Rating Scale (PARS) is a clinician-administered instrument that assesses the frequency, severity, and impairment of common pediatric anxiety disorders and has been used as a primary outcome…

  10. Tratamiento exitoso de un hemangioma de parótida con propranolol

    National Research Council Canada - National Science Library

    Edelisa Moredo Romo; Fernanda Pastrana Fundora

    2012-01-01

    .... Se presenta el caso clínico de un paciente con diagnóstico de hemangioma de parótida con componente superficial y profundo, tratado con propranolol, con excelente respuesta al tratamiento, involución completa clínica...

  11. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  12. Optimisation de la production d'éthanol par les techniques d ...

    African Journals Online (AJOL)

    hydrolyse de l'amidon. Il vaut mieux produire l'éthanol à partir d'une fermentation contrôlée pour éviter les intoxications provoquées par le méthanol. Mots clés: fermentation alcoolique, Saccharomyces cerevisiae, amidon de ...

  13. uPAR-targeted multimodal tracer for pre- and intraoperative imaging in cancer surgery

    NARCIS (Netherlands)

    Boonstra, M.C.; Van Driel, P.B.A.A.; Van Willigen, D.M.; Stammes, M.A.; Prevoo, H.A.J.M.; Tummers, Q.R.J.G.; Mazar, A.P.; Beekman, F.J.; Kuppen, P.J.K.; Van de Velde, C.J.H.; Löwik, C.W.G.M.; Frangioni, J.V.; Van Leeuwen, F.W.B.; Sier, C.F.M.; Vahrmeijer, A.L.

    2015-01-01

    Pre- and intraoperative diagnostic techniques facilitating tumor staging are of paramount importance in colorectal cancer surgery. The urokinase receptor (uPAR) plays an important role in the development of cancer, tumor invasion, angiogenesis, and metastasis and over-expression is found in the

  14. Une occlusion intestinale aiguë par un os de poulet | Mahmoudi ...

    African Journals Online (AJOL)

    Il s'agit le plus souvent d'un accident survenant chez des enfants, parfois chez des malades psychiatriques. Chez les adultes, l'accident est favorisé par des mauvaises habitudes alimentaires (repas trop rapide, quintes de toux ou dispute lors du repas...). L'introduction ... Les suites opératoires étaient simples. Pan African ...

  15. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  16. Tuberculose de l'épaule masquée par une infection concomitante à ...

    African Journals Online (AJOL)

    Tuberculose de l'épaule masquée par une infection concomitante à enterobacter cloacae: à propos d'un cas. Mariam Gbané-Koné, Samba Koné, Boubacar Ouali, Kouassi Jean-Mermoz Djaha, Mohamed Diomandé, Edmond Eti, Stanislas André Touré, N'zué Marcel Kouakou ...

  17. Préparation des charbons actifs par voie chimique à l'acide ...

    African Journals Online (AJOL)

    Les matieres ligno-cellulosiques sont des precurseurs du charbon actif. Le present travail a eu pour but la preparation de charbons actifs a partir des coques de noix de coco par activation chimique a lfacide phosphorique. Pour optimiser le procede de la preparation, les effets des concentrations de lfacide phosphorique ...

  18. Elimination du cadmium de l'acide phosphorique par électrodialyse ...

    African Journals Online (AJOL)

    homme; elle est devenue un enjeu économique et politique majeur pour le développement durable des pays. L'acide phosphorique est classé en second lieu dans la production mondiale des acides après l'acide sulfurique. Il est fabriqué par ...

  19. Que sont devenues les plantes autrefois consommées par les divers ...

    African Journals Online (AJOL)

    Que sont devenues les plantes autrefois consommées par les divers groupes ethnoculturels du Togo? S Akpavi, AY Woegan, M Dourma, K Tozo, K Batawila, K Wala, KA Gbogbo, M Kanda, K Kossi-Titrikou, B de Foucault, I Butare, K Akpagana ...

  20. La bio-indication de la pollution aquatique par les microalgues (Cas ...

    African Journals Online (AJOL)

    JS.II. Resume. Les milieux aquatiques continentaux sont des ecosystemes complexes, fragiles et regis par des lois physico-chimiques precises. Les microalgues qui les colonisent vivent en equilibre instable et en dependent totalement. Les genres les plus tolerants s'adaptent a l'entree d'une substance exogene ou a une ...