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Sample records for estroma gastrintestinal gist

  1. Imatinib and gastrointestinal stromal tumor (GIST: a selective targeted therapy Imatinib y tumor del estroma gastrointestinal (GIST: un tratamiento selectivo frente a una diana molecular

    Directory of Open Access Journals (Sweden)

    A. Fernández

    2004-10-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors in the gastrointestinal tract. They originate from the interstitial cells of Cajal and are characterized by an anomalous receptor for a growth factor with tyrosine-kinase activity (c-kit. This anomaly causes a permanent activation of the receptor and uncontrolled cell growth. These tumors show a poor response to traditional chemotherapy drugs, and are thus associated with low survival in cases of advanced disease. Imatinib, a tyrosine kinase inhibitor, is an example of selective targeted oncologic therapy that induces improved survival in these patients. We discuss two cases of metastatic gastrointestinal stromal tumors with a good response to imatinib, and also review the pathophysiology and treatment-related outcome of this type of tumors. We include results from clinical phase-III studies.Los tumores del estroma gastrointestinal son los tumores mesenquimales más frecuentes del tracto digestivo y se originan de las células intersticiales de Cajal. Se caracterizan por presentar un receptor para el factor de crecimiento con actividad tirosin kinasa (c-kit anómalo que condiciona su activación permanente y un crecimiento celular incontrolado. Tienen una baja supervivencia en casos de enfermedad avanzada, con escasa respuesta a los agentes quimioterápicos tradicionales. El imatinib es un fármaco inhibidor de la tirosín kinasa y un ejemplo de terapia oncológica selectiva que condiciona un importante aumento en la supervivencia de estos pacientes. Se presentan 2 casos de enfermedad metastásica con buena respuesta a imatinib, así como una revisión sobre la fisiopatología y evolución en el tratamiento de este tipo de tumores, incluyendo resultados de estudios en fase III.

  2. Tumor del estroma gastrointestinal Tumor of the gastrointestinal stroma

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    Jorge Felipe Montero León

    2012-03-01

    Full Text Available Los tumores del estroma gastrointestinal, conocidos según sus siglas en inglés como GIST (gastrointestinal stromal tumors, son tumores mesenquimales que aparecen en cualquier lugar a lo largo del tracto intestinal. Este trabajo tiene el propósito de presentar una paciente de 60 años de edad que asiste a la consulta de ginecología del Instituto Nacional de Oncología y Radiobiología, por presentar dolor en el epigastrio, que se irradia al flanco derecho, con un aumento de volumen en la fosa iliaca derecha, y por ultrasonografía se plantea un tumor de ovario derecho, que se proyecta hacia el epigastrio y a hipocondrio derecho. Se describe la intervención quirúrgica y los hallazgos encontrados en estudios macro y microscópicos, así como en estudios posteriores por inmunohistoquímica de la lesión. Se concluye con un diagnóstico de tumor del estroma gastrointestinal y los resultados de las intervenciones quirúrgicas y medicamentosas realizadas. Se recomienda valorar la importancia de una estrecha relación entre cirujanos generales y ginecólogos frente a enfermedades inesperadas, por su difícil diagnóstico preoperatorio, que conllevan a un tratamiento quirúrgico adecuado, y que por la complejidad que requieren, necesitan de la competencia de ambas especialidades quirúrgicas.The tumors of the gastrointestinal stroma, known in English language as GIST (gastrointestinal stromal tumors are mesenchymal tumors appearing in any place throughout the intestinal tract. The objective of present paper is to present the case of a female patient aged 60 came to Genecology consultation of the National Institute of Oncology and Radiobiology due pain in epigastrium irradiating to right flank with increase of volume in the right iliac fossa and by ultrasonography it is a tumor of right ovarium projecting to epigastrium and the right hypochondrium. The surgical intervention is described as well as the findings noted in macro- and microscopic studies

  3. Stromal gastrointestinal tumors (GIST)

    International Nuclear Information System (INIS)

    Balev, B.; Boykova, K.

    2015-01-01

    Full text: GIST are a heterogeneous group of mesenchymal tumors of the gastrointestinal tract with varying tumor grade and frequency of 1: 100 000 per year. Mazur and Clark introduced the term for the first time in 1983. GIST constitute approximately 2% of the tumors in the gastrointestinal tract. The average age is 60 years. The most common locations are the stomach (60%), small intestine (30%), esophagus (1%), and rectum (5%). Learning objective: to demonstrate the imaging characteristics of the disease according to the current ESMO guidelines and to present the diagnostic accuracy of different imaging modalitiesnbased on review of literature and on own observations. GIST originate from interstitial cells (of Cajal) in the GIT wall, belonging to the autonomic nervous system, which is responsible for motility. 90% of GIST show overexpression of the KIT receptor, also known as CD117 or stem cell factor receptor. those that do not express c-KIT mutations, activate mutations in PDGFRA gene. Tumor’s macromorphology determines the imaging features on different modalities. Most of these tumors are exophytic, subepithelial, reach large size and enhance inhomogeneous due to necrosis. They usually do not cause obstruction. Ultrasound as the initiation method shows low sensitivity and specificity in GIST detection, CT with intravenous contrast is the gold standard. MRI contributes with assessing the vascularisation, cellularity and pH. FDG-PET/CT registers the metabolism of intratumoral acidosis. CT is the method of choice in the early diagnosis and determination of resectability of GIST. MRI is an additional method. PET FDG-CT is useful for the monitoring of patients treated with Imatinib

  4. [Gastric mesenchymal tumours (GIST)].

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    Spivach, Arrigo; Fezzi, Margherita; Sartori, Alberto; Belgrano, Manuel; Rimondini, Alessandra; Cuttin-Zernich, Roberto; Covab, Maria Assunta; Bonifacio, Daniela; Buri, Luigi; Pagani, Carlo; Zanconati, Fabrizio

    2008-01-01

    The incidence of gastrointestinal stromal tumours (GIST) has increased in recent years. A number of authors have attempted to define the actual nature of these tumours. Immunohistochemistry highlighting the positivity of tyrosine-kinase (CD117/c-Kit) has revealed the difference between gastrointestinal stromal tumours and other mesenchymal tumours and, therefore, the possibility of medical rather than surgical therapy. We retrospectively reviewed 19 patients affected by primary gastric GIST, who underwent surgery in recent years with subsequent follow-up. Gastroscopy and gastrointestinal tract radiography were used not only to obtain the diagnosis but also to establish the size, density, contours, ulceration, regional lymphadenopathy, mesenteric infiltration and the presence of metastases. The aim of this study was to evaluate the roles of endoscopy and radiology in this pathology and the advantages and limitations of each individual technique.

  5. Sarcoma de estroma prostático gigante

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    Jose Luis González González

    Full Text Available Los tumores de próstata representan la neoplasia maligna más frecuente en el varón. Mientras que las lesiones epiteliales son frecuentes, las neoplasias de origen mesenquimal representan entre 1 y 2 % de las neoplasias malignas prostáticas. Son poco conocidas, sobre todo las de origen estromal. Se presenta el caso de un varón de 77 años de edad, con un sarcoma del estroma prostático al que se le realiza una exéresis parcial. El tumor ocupa prácticamente la totalidad de la cavidad pélvico-abdominal, con un diámetro de 35 cm y un peso de 3 800 g. Histológicamente se concluyó, como sarcoma prostático aunque en el transoperatorio no se encontró un nexo evidente con este órgano. El comportamiento clínico de estos tumores, basado en los escasos casos descritos en la literatura, es prácticamente desconocido y su diagnóstico preoperatorio difícil. Este paciente se presentó con pérdida de peso, sin dolor, hematuria, ni síntomas obstructivos.

  6. GASTROINTESTINAL STROMAL TUMOR (GIST

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    Luigi eTornillo

    2014-11-01

    Full Text Available Gastrointestinal stromal tumors are the most frequent mesenchymal tumors of the gastrointestinal tract. The discovery that these tumors, formerly thought of smooth muscle origin, are indeed better characterized by specific activating mutation in genes coding for the receptor tyrosine kinases CKIT and PDGFRA and that these mutations are strongly predictive for the response to targeted therapy with receptor tyrosine kinase inhibitors has made GISTs the typical example of the integration of basic molecular knowledge in the daily clinical activity. The information on the mutational status of these tumors is essential to predict (and subsequently to plan the therapy. As resistant cases are frequently wild-type, other possible oncogenic events, defining other entities, have been discovered (e.g. succinil dehydrogenase mutation/dysregulation, insuline growth factor expression, mutations in the RAS-RAF-MAPK pathway. The classification of disease must nowadays rely on the integration of the clinico-morphological characteristics with the molecular data.

  7. Tumor Estromal Gastrintestinal de Localização Esofágica: Relato de Caso/ Gastrointestinal Stromal Tumor Location Esophageal: Case Report

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    Daniele Ribeiro Matsumoto

    2013-06-01

    Full Text Available Introdução: Os tumores estromais gastrintestinais (GIST são considerados as neoplasias mesenquimatosas mais comuns do trato gastrintestinal (TGI. São derivados das células intersticiais de Cajal, localizadas ao nível do plexo mioentérico e responsáveis pela motilidade gastrintestinal. Podem se originar em qualquer região do TGI, sendo apenas 5% provenientes do esôfago. Casuística: Foi relatado um caso de GIST de localização esofágica em um paciente que iniciou quadro de disfagia para alimentos sólidos e odinofagia, de caráter intermitente, acompanhado de náuseas e vômitos. Foram realizadas Seriografia contrastada de esôfago, Endoscopia Digestiva Alta, Tomografia Computadorizada de Abdome, o resultado histopatológico da biópsia da lesão foi inconclusivo e o diagnóstico foi confirmado pela imunohistoquímica que expressou CD117 (KIT pelas células neoplásicas. O serviço de oncologia de referência orientou a realização de cirurgia para ressecção tumoral, porém o paciente optou pela utilização do Mesilato de Imatinib (MI, tendo apresentado melhora progressiva do quadro clínico inicial. Discussão: O tratamento padrão para pacientes com GIST não metastático é a ressecção completa da lesão, pois oferece a maior chance de cura. Entretanto, o paciente optou somente pelo tratamento com o MI. Conclusão: Concluímos que o GIST deve ser considerado nas lesões exofíticas esofágicas e que o tratamento somente com o MI pode ser considerado, mesmo sabendo que o tratamento preconizado nestes casos é a ressecção cirúrgica, associada ao MI como terapia adjuvante, com melhora da sobrevida. Introduction: The gastrointestinal stromal tumor (GIST considered the most common mesenchymal neoplasm of the gastrointestinal tract (GIT. It is derived from interstitial cells of Cajal, located at the myenteric plexus and responsible for gastrointestinal motility. It can originate anywhere in the GI tract, and only 5% come from

  8. Characteristics of Emergency Gastrointestinal Stromal Tumor (GIST).

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    Uçar, Ahmet Deniz; Oymaci, Erkan; Carti, Erdem Bariş; Yakan, Savaş; Vardar, Enver; Erkan, Nazif; Mehmet, Yildirim

    2015-05-01

    Gastrointestinal Stromal Tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract (GIT). Importance of GISTs is increasing while surgeons are facing with more frequent either in emergency setting of elective cases. Delineating the presentation and management of emergency GIST is important. From 2005 to 2014, emergency cases with final diagnosis of GIST were examined retrospectively. Total of 13 operated cases were evaluated by patients characteristics, clinical presentation, operational findings and postoperative prognosis. There were 9 male and 4 female with the mean age of 48.15 years. The most frequent presentations are ileus and GIT hemorrhage both covering the 84% of patients. Small bowel was the dominating site with ileus. Stomach was the second frequent site of the disease with the finding of hemorrhage. Emergency patients are more likely to come with small bowel GIST and obstruction symptoms. Hemorrhage is the most frequent symptom for emergency GIST of stomach and duodenum.

  9. Imaging of gastrointestinal stromal tumour (GIST)

    International Nuclear Information System (INIS)

    Lau, S.; Tam, K.F.; Kam, C.K.; Lui, C.Y.; Siu, C.W.; Lam, H.S.; Mak, K.L.

    2004-01-01

    Gastrointestinal stromal tumour (GIST) represents the most common kind of mesenchymal tumour that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumour containing spindle cells (or less commonly epithelioid cells or rarely both) and showing CD117 (c-kit protein) positivity. Targeted molecular therapy of non-resectable GIST using imatinib, a specific tyrosine kinase receptor inhibitor, represents a real milestone in the management of solid malignancy. Imaging studies, both anatomical and functional, are playing an increasingly important role in management of patients with GIST. This review illustrates the radiological appearance of GISTs and the site-specific roles of each imaging tool. Clinical features and radiological differential diagnosis of GIST are also discussed

  10. Tratamento adjuvante nos GISTs Adjuvant treatment in GISTs

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    Laercio Gomes Lourenço

    2011-09-01

    Full Text Available INTRODUÇÃO: O tumor estromal gastrointestinal (GIST é o sarcoma mais comum do aparelho digestivo. Essa neoplasia ocorre devido à mutação do gene KIT com consequente ativação constitutiva da proteína KIT. O tratamento primário é cirúrgico e consiste na sua ressecção completa. Entretanto, alguns grupos de pacientes apresentam risco elevado de recorrência mesmo após operação com ressecção completa (R0, indicando diferenças no comportamento biológico. Estudos clínicos comprovaram a atividade clínica do mesilato de imatinibe, fazendo dele a primeira linha de tratamento padrão nos GISTs metastáticos ou irressecáveis, mudando muito o desfecho clínico dessa doença em relação aos benefícios anteriormente obtidos com a quimioterapia antineoplásica. MÉTODO: Foi realizada revisão da literatura com consulta nos periódicos das bases Medline/Pubmed, Scielo e Lilacs cruzando os descritores: tumor estromal gastrointestinal, Gist, tratamento, adjuvância. Além desta revisão foi adicionada a experiência pessoal dos autores. CONCLUSÃO: Melhor refinamento dos critérios de prognóstico tem permitido selecionar de forma mais adequada pacientes para o tratamento adjuvante com imatinibe. Os resultados de maior evidência até o momento respaldam o tratamento adjuvante por um ano, o que produz benefício significativo na sobrevida livre de recidiva, mas não na sobrevida global desses pacientes.INTRODUCTION: Gastrointestinal stromal tumor (GIST is the most common sarcoma of the digestive tract. This cancer occurs due to mutation of the KIT gene resulting in constitutive activation of KIT protein. The primary treatment is surgical and consists of complete resection. However, some groups of patients at high risk of recurrence even after surgery with complete resection (R0, indicate differences in biological behavior. Clinical studies have demonstrated the clinical activity of imatinib mesylate, making it the standard first

  11. Punções do estroma anterior no tratamento da ceratopatia bolhosa

    OpenAIRE

    Gomes,José Alvaro Pereira; Haraguchi,Daniel Keizo de Medeiros; Zambrano,Delbis Uzcátegui; Villavicencio,Luis Izquierdo; Cunha,Marcelo C.; Freitas,Denise de

    2000-01-01

    Objetivo: Avaliar o efeito terapêutico das punções do estroma anterior corneal em pacientes com ceratopatia bolhosa (CB). Métodos:Vinte e cinco pacientes com CB sintomáticos, com baixa visão, com e sem indicação de transplante de córnea, foram avaliados antes, uma, 4 e 12 semanas após punções estromais anteriores realizadas com agulha #25 à lâmpada de fenda. Em cada visita, os pacientes foram questionados sobre intensidade da dor, fotofobia, sensação de corpo estranho, além de serem submetido...

  12. Broadcast news gisting using lexical cohesion analysis

    OpenAIRE

    Stokes, Nicola; Newman, Eamonn; Carthy, Joe; Smeaton, Alan F.

    2004-01-01

    In this paper we describe an extractive method of creating very short summaries or gists that capture the essence of a news story using a linguistic technique called lexical chaining. The recent interest in robust gisting and title generation techniques originates from a need to improve the indexing and browsing capabilities of interactive digital multimedia systems. More specifically these systems deal with streams of continuous data, like a news programme, that require further annotation be...

  13. Cobre no controle da verminose gastrintestinal em ovinos Copper on the control of gastrintestinal nematodes in sheep

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    Isabel Gonçalves de Gonçalves

    2004-02-01

    was to verify the possible activity of copper oxide wire particles against reinfection by gastrintestinal nematodes in sheep under extensive grazing. Thirty-two sheep, all wethers, aged 18 months and kept on native pastures naturally contaminated by trichostrongylides were used. The animals were weighed and treated with anthelmintics and then allocated to four experimental groups: T I (treated with copper and necropsied on Day 28, T II (untreated control and necropsied on Day 28, T III (treated with copper and necropsied on Day 56, T IV (untreated control and necropsied on Day 56. Groups T I e T III received, per os, a 4g bolus containing 3.4g of copper oxide wire particles. The animals were monitored, at weekly intervals, for faecal egg counts (EPG, packed cell volume (PCV, aspartate aminotransferase (AST and plasma copper concentration. At necropsy, worm burdens, liver copper concentration and liver weights were determined. There were no differences in plasma copper levels between treatments (P>0.05. As for copper in the livers, all treated groups had higher levels than the untreated animals (P0.05. Worm counting at necropsy revealed that copper was effective only against Haemonchus contortus and only in the animals slaughtered on Day 28º where the reduction was 60% in comparison to the untreated group (P0.05. It is concluded that 3.4g of copper oxide wire particles can have a significant action in reducing reinfections by H. contortus during four weeks without toxicity to animals under conditions of extensive grazing.

  14. Sporadic diffuse segmental interstitial cell of Cajal hyperplasia harbouring two gastric gastrointestinal stromal tumours (GIST mimicking hereditary GIST syndromes

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    Mafalda Costa Neves

    2015-01-01

    Conclusion: We describe a diffuse form of sporadic ICC hyperplasia harbouring multifocal GISTs, mimicking diffuse ICC hyperplasia in hereditary GIST syndromes. Detection of somatic c-KIT exon 11 mutation ruled out a hereditary disorder.

  15. Synchronous GISTs associated with multiple sporadic tumors: a case report

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    Danila Comandini

    2017-08-01

    Full Text Available Gastrointestinal stromal tumors (GISTs are rare neoplasms, but they also represent the most common mesenchymal tumors of the gastrointestinal tract originating from the cell of Cajal. GIST incidence ranges around 1% of all gastrointestinal malignancies. Approximately 5% of all GISTs have a hereditary etiology. The remaining 95% of GISTs are considered sporadic events, with up to 75% of cases driven by a constitutional activation of the c-KIT proto-oncogene. GISTs are generally solitary lesions. Nonetheless, multiple sporadic GISTs can occur and present as synchronous or metachronous tumors, usually associated with familial GIST. Here, we report a case of primary prostate and lung tumors associated with gastric and small bowel GISTs, unrelated to any known hereditary syndrome. Also, in the case we describe, the prostatic tumor came before the GISTs, while the lung tumor occurred later in time and led to pulmonary lobectomy plus lymphoadenectomy, with a diagnosis of nonsmall cell lung cancer. With the exception of a slight difference in lymphoid infiltration, the abdominal and gastric GIST nodules shared the same proliferative MIB1 index and mitotic count. However, the genetic analysis revealed that the gastric GIST and abdominal tumors were characterized by two different c-KIT mutations. This molecular heterogeneity supported the hypothesis of two different synchronous GISTs arising from stomach and ileum. At present, the patient is disease free and has already completed the third year of adjuvant therapy with imatinib. This case supports the importance of the analysis of c-KIT mutational status to distinguish metastases from synchronous multicentric GISTs, with relevant implications in therapeutic decisions, as well as the importance of a dedicated multidisciplinary team and of a radiological follow-up after the diagnosis of a primary GIST, to discover a relapse of the GIST or, possibly, additional malignancies.

  16. GIST gástrico: revisión de la literatura a propósito de un caso

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    Daniela V Blanco-Echezuría

    2009-01-01

    Full Text Available Los tumores del estroma gastrointestinal son los tumores mesenquimales más frecuentes del tubo digestivo. Corresponden a 0.1% a 3% de las neoplasias gastrointestinales y 5% a 6% de todos los sarcomas. Se trata de paciente femenina de 59 años de edad quien refiere en Enero de 2009 Rectorragia roja con coágulos, posteriormente Melena. La realización de una endoscopia digestiva superior reporta Tumor submucoso en fundus que se complementa con US endoscópico, evidenciando lesión submucosa en fundus gástrico, GIST gástrico. La sintomatología depende de la localización del proceso neoproliferativo, hallándose con mayor frecuencia en el estómago (60-70%. La supervivencia tras citorreducción R0 a 5 años es de 40% a 65%, con recurrencia del 20%, sin embargo, disminuye a 9-12 meses si la reducción fue incompleta.

  17. Análisis de una nueva variante fenotípica de distrofia del estroma corneal

    OpenAIRE

    Varela Conde, Yago

    2016-01-01

    Las distrofias corneales son un conjunto de enfermedades hereditarias de la córnea con base genética demostrable y sin afectación sistémica. Su nomenclatura y clasificación han sido revisadas recientemente, prescindiendo de ciertas patologías y agrupando las distrofias en nuevas categorías. Se ha hallado una variante fenotípica atípica con afectación del estroma corneal, por lo que sólo se han revisado las distrofias corneales localizadas a ese nivel (epiteliales-estromales y estromales). ...

  18. Estudo da atividade do látex do Croton urucurana Baill. sobre o trânsito gastrintestinal de camundongos

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    Luilma Albuquerque Gurgel

    Full Text Available O presente trabalho tem como propósito avaliar uma possível atividade inibitória do látex do Croton urucurana Baill. sobre o trânsito gastrintestinal de camundongos, bem como tentar esclarecer os possíveis mecanismos de ação envolvidos em sua atividade. Foram utilizados os modelos de trânsito gastrintestinal normal e trânsito gastrintestinal estimulado por fisostigmina em camundongos. Os resultados obtidos mostram que o látex inibiu o trânsito gastrintestinal de camundongos, e, muito embora seu mecanismo de ação ainda não seja claro, seu efeito é independente da participação de mecanismo opióide, colinérgico, α2-adrenérgico ou nitriérgico.

  19. Tutorial dialogues and gist explanations of genetic breast cancer risk.

    Science.gov (United States)

    Widmer, Colin L; Wolfe, Christopher R; Reyna, Valerie F; Cedillos-Whynott, Elizabeth M; Brust-Renck, Priscila G; Weil, Audrey M

    2015-09-01

    The intelligent tutoring system (ITS) BRCA Gist is a Web-based tutor developed using the Shareable Knowledge Objects (SKO) platform that uses latent semantic analysis to engage women in natural-language dialogues to teach about breast cancer risk. BRCA Gist appears to be the first ITS designed to assist patients' health decision making. Two studies provide fine-grained analyses of the verbal interactions between BRCA Gist and women responding to five questions pertaining to breast cancer and genetic risk. We examined how "gist explanations" generated by participants during natural-language dialogues related to outcomes. Using reliable rubrics, scripts of the participants' verbal interactions with BRCA Gist were rated for content and for the appropriateness of the tutor's responses. Human researchers' scores for the content covered by the participants were strongly correlated with the coverage scores generated by BRCA Gist, indicating that BRCA Gist accurately assesses the extent to which people respond appropriately. In Study 1, participants' performance during the dialogues was consistently associated with learning outcomes about breast cancer risk. Study 2 was a field study with a more diverse population. Participants with an undergraduate degree or less education who were randomly assigned to BRCA Gist scored higher on tests of knowledge than those assigned to the National Cancer Institute website or than a control group. We replicated findings that the more expected content that participants included in their gist explanations, the better they performed on outcome measures. As fuzzy-trace theory suggests, encouraging people to develop and elaborate upon gist explanations appears to improve learning, comprehension, and decision making.

  20. Emotionally negative pictures enhance gist memory.

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    Bookbinder, S H; Brainerd, C J

    2017-02-01

    In prior work on how true and false memory are influenced by emotion, valence and arousal have often been conflated. Thus, it is difficult to say which specific effects are caused by valence and which are caused by arousal. In the present research, we used a picture-memory paradigm that allowed emotional valence to be manipulated with arousal held constant. Negatively valenced pictures elevated both true and false memory, relative to positive and neutral pictures. Conjoint recognition modeling revealed that negative valence (a) reduced erroneous suppression of true memories and (b) increased the familiarity of the semantic content of both true and false memories. Overall, negative valence impaired the verbatim side of episodic memory but enhanced the gist side, and these effects persisted even after a week-long delay. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  1. A multidisciplinary approach for the treatment of GIST liver metastasis

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    Paramo Juan C

    2008-05-01

    Full Text Available Abstract Background Advanced gastrointestinal stromal tumors (GISTs can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. Case presentation A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resection 7 years prior for a primary GIST of the small bowel. The finding of a heterogeneous mass 15.5 cm in diameter replacing most of the left lobe of the liver by ultrasonography and CT, followed by positive cytological studies revealed a metastatic GIST. Perioperative optimization of the patient's nutritional status along with biliary drainage, and portal vein embolization were performed. Imatinib was successful in reducing the tumor size and facilitating surgical resection. Conclusion A well-planned multidisciplinary approach should be part of the standard management of advanced or metastatic GIST.

  2. A multidisciplinary approach for the treatment of GIST liver metastasis

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    Radkani, Pejman; Ghersi, Marcelo M; Paramo, Juan C; Mesko, Thomas W

    2008-01-01

    Background Advanced gastrointestinal stromal tumors (GISTs) can metastasize and recur after a long remission period, resulting in serious morbidity, mortality, and complex management issues. Case presentation A 67-year-old woman presented with epigastric fullness, mild jaundice and weight loss with a history of a bowel resection 7 years prior for a primary GIST of the small bowel. The finding of a heterogeneous mass 15.5 cm in diameter replacing most of the left lobe of the liver by ultrasonography and CT, followed by positive cytological studies revealed a metastatic GIST. Perioperative optimization of the patient's nutritional status along with biliary drainage, and portal vein embolization were performed. Imatinib was successful in reducing the tumor size and facilitating surgical resection. Conclusion A well-planned multidisciplinary approach should be part of the standard management of advanced or metastatic GIST. PMID:18471285

  3. Current management and prognostic features for gastrointestinal stromal tumor (GIST

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    Lamba Gurpreet

    2012-06-01

    Full Text Available Abstract Stromal or mesenchymal neoplasms affecting the gastrointestinal (GI tract have undergone a remarkable evolution in how they are perceived, classified, approached, diagnosed and managed over the last 30 years. Gastrointestinal stromal tumors (GIST account for approximately 1% to 3% of all malignant GI tumors. The clinical features can vary depending on the anatomic location, size and aggressiveness of the tumor. Metastatic GIST represents a successful example of molecular targeted therapy. In this comprehensive review, we discuss the epidemiology, clinical features and diagnostic modalities for GIST. We also describe treatment options for early stage, locally advanced and metastatic GIST. Indications for neoadjuvant and adjuvant therapy along with duration of therapy are also explained. A brief discussion of latest biomarkers and updates from recent meetings is also provided.

  4. Gist memory in Alzheimer's disease: evidence from categorized pictures.

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    Budson, Andrew E; Todman, Raleigh W; Schacter, Daniel L

    2006-01-01

    The authors investigated gist memory (the general meaning, idea, or gist conveyed by a collection of items) for categorized color photographs in patients with Alzheimer's disease (AD) using an experimental paradigm in which participants are instructed to respond "yes" when a test item fits with a previously studied category, regardless of whether the specific item was actually studied. Compared with controls, the patients endorsed fewer studied items and similar numbers of nonstudied lure items. After the authors corrected for the baseline false-alarm rate, the patients showed a lower level of endorsements for nonstudied lure items compared with that of controls, suggesting that their gist memory is impaired. Implications of these findings for understanding gist memory and response bias in patients with AD are discussed.

  5. Experiences and perspectives on the GIST patient journey.

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    Macdonald, Nancy; Shapiro, Ari; Bender, Christina; Paolantonio, Marc; Coombs, John

    2012-01-01

    The tyrosine kinase inhibitor (TKI) imatinib has improved outcomes for patients with unresectable or metastatic gastrointestinal stromal tumors (GIST), and for patients receiving adjuvant therapy following GIST resection. This qualitative study explored the experiences and emotions of patients through GIST diagnosis, treatment initiation, disease control, and in some patients, loss of response and therapy switch. Ethnographic investigations were conducted, including semi- structured qualitative interviews of patients with resected or metastatic/unresectable GIST and their caregivers, from Canada (n = 15); the United States (n = 10); and Brazil, France, Germany, Russia, and Spain (n = 5 each). Some interviewees also kept 7-day photo journals. Responses were qualitatively analyzed to identify gaps and unmet needs where communication about disease, treatments, and adherence could be effective. Patients shared common experiences during each stage of disease management (crisis, hope, adaptation, new normal, and uncertainty). Patients felt a sense of crisis during diagnosis, followed by hope upon TKI therapy initiation. Over time, they came to adapt to their new lives (new normal) with cancer. With each follow-up, patients confronted the uncertainty of becoming TKI resistant and the possible need to switch therapy. During uncertainty many patients sought new information regarding GIST. Cases of disease progression and drug switching caused patients to revert to crisis and restart their emotional journey. Patients with primary or unresectable/metastatic GIST shared similar journeys, especially regarding uncertainty, although differences in the scope and timing of phases were observed. Strategies patients used to remain adherent included obtaining family support, setting reminder mechanisms, taking medicine at routine times, and storing medicine in prominent places. Physicians and support staff can manage patient expectations and encourage adherence to therapy, which may

  6. Understanding Genetic Breast Cancer Risk: Processing Loci of the BRCA Gist Intelligent Tutoring System.

    Science.gov (United States)

    Wolfe, Christopher R; Reyna, Valerie F; Widmer, Colin L; Cedillos-Whynott, Elizabeth M; Brust-Renck, Priscila G; Weil, Audrey M; Hu, Xiangen

    2016-07-01

    The BRCA Gist Intelligent Tutoring System helps women understand and make decisions about genetic testing for breast cancer risk. BRCA Gist is guided by Fuzzy-Trace Theory, (FTT) and built using AutoTutor Lite. It responds differently to participants depending on what they say. Seven tutorial dialogues requiring explanation and argumentation are guided by three FTT concepts: forming gist explanations in one's own words, emphasizing decision-relevant information, and deliberating the consequences of decision alternatives. Participants were randomly assigned to BRCA Gist , a control, or impoverished BRCA Gist conditions removing gist explanation dialogues, argumentation dialogues, or FTT images. All BRCA Gist conditions performed significantly better than controls on knowledge, comprehension, and risk assessment. Significant differences in knowledge, comprehension, and fine-grained dialogue analyses demonstrate the efficacy of gist explanation dialogues. FTT images significantly increased knowledge. Providing more elements in arguments against testing correlated with increased knowledge and comprehension.

  7. Presentation of GIST as jejuno-jejunal intussusception

    Directory of Open Access Journals (Sweden)

    Anil Kumar

    2018-03-01

    Full Text Available Gastrointestinal stromal tumours (GISTs are rare tumour. It comprises 0.2% of gastrointestinal tumours and only 0.04% of small intestinal tumours. Usually this tumour is found in people in their 60s.These tumours can be found anywhere in the gastrointestinal tract but most commonly found in the stomach (40–60%. Patients with GISTs usually have vague and nonspecific symptoms. We present a 17year-old with complain of abdominal pain, distension, and few episodes of vomiting. All laboratory investigations were normal. The ultrasonography (USG and computed tomography (CT were suggestive of jejuno-jejunal intussusception. The patient had emergency exploratory laparotomy with resection of the segment with five cm healthy margin, and end to end anastomosis. Patient was discharged after 4 days and remains well. This case report highlights the rarity of GISTs in the concern of age (17 year old, site (Jejunum as well as presentation (intussusception.

  8. Inoculating against eyewitness suggestibility via interpolated verbatim vs. gist testing.

    Science.gov (United States)

    Pansky, Ainat; Tenenboim, Einat

    2011-01-01

    In real-life situations, eyewitnesses often have control over the level of generality in which they choose to report event information. In the present study, we adopted an early-intervention approach to investigate to what extent eyewitness memory may be inoculated against suggestibility, following two different levels of interpolated reporting: verbatim and gist. After viewing a target event, participants responded to interpolated questions that required reporting of target details at either the verbatim or the gist level. After 48 hr, both groups of participants were misled about half of the target details and were finally tested for verbatim memory of all the details. The findings were consistent with our predictions: Whereas verbatim testing was successful in completely inoculating against suggestibility, gist testing did not reduce it whatsoever. These findings are particularly interesting in light of the comparable testing effects found for these two modes of interpolated testing.

  9. Succinate Dehydrogenase Subunit B (SDHB Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists: Implications for the SDHB Expression Based Classification of Gists

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    Jeanny H. Wang, Jerzy Lasota, Markku Miettinen

    2011-01-01

    Full Text Available Gastrointestinal Stromal Tumor (GIST is the most common mesenchymal tumor of the digestive tract. GISTs develop with relatively high incidence in patients with Neurofibromatosis-1 syndrome (NF1. Mutational activation of KIT or PDGFRA is believed to be a driving force in the pathogenesis of familial and sporadic GISTs. Unlike those tumors, NF1-associated GISTs do not have KIT or PGDFRA mutations. Similarly, no mutational activation of KIT or PDGFRA has been identified in pediatric GISTs and in GISTs associated with Carney Triad and Carney-Stratakis Syndrome. KIT and PDGFRA-wild type tumors are expected to have lesser response to imatinib treatment. Recently, Carney Triad and Carney-Stratakis Syndrome -associated GISTs and pediatric GISTs have been shown to have a loss of expression of succinate dehydrogenase subunit B (SDHB, a Krebs cycle/electron transport chain interface protein. It was proposed that GISTs can be divided into SDHB- positive (type 1, and SDHB-negative (type 2 tumors because of similarities in clinical features and response to imatinib treatment. In this study, SDHB expression was examined immunohistochemically in 22 well-characterized NF1-associated GISTs. All analyzed tumors expressed SDHB. Based on SDHB-expression status, NF1-associated GISTs belong to type 1 category; however, similarly to SDHB type 2 tumors, they do not respond well to imatinib treatment. Therefore, a simple categorization of GISTs into SDHB-positive and-negative seems to be incomplete. A classification based on both SDHB expression status and KIT and PDGFRA mutation status characterize GISTs more accurately and allow subdivision of SDHB-positive tumors into different clinico-genetic categories.

  10. File list: ALL.Dig.10.AllAg.GIST-48 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Dig.10.AllAg.GIST-48 hg19 All antigens Digestive tract GIST-48 SRX825987,SRX023...216,SRX023215,SRX825986 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Dig.10.AllAg.GIST-48.bed ...

  11. File list: ALL.Dig.50.AllAg.GIST-48 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Dig.50.AllAg.GIST-48 hg19 All antigens Digestive tract GIST-48 SRX825987,SRX023...216,SRX023215,SRX825986 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Dig.50.AllAg.GIST-48.bed ...

  12. File list: ALL.Dig.20.AllAg.GIST-48 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ALL.Dig.20.AllAg.GIST-48 hg19 All antigens Digestive tract GIST-48 SRX825987,SRX023...216,SRX825986,SRX023215 http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/assembled/ALL.Dig.20.AllAg.GIST-48.bed ...

  13. The Influence of Color on the Perception of Scene Gist

    Science.gov (United States)

    Castelhano, Monica S.; Henderson, John M.

    2008-01-01

    In 3 experiments the authors used a new contextual bias paradigm to explore how quickly information is extracted from a scene to activate gist, whether color contributes to this activation, and how color contributes, if it does. Participants were shown a brief presentation of a scene followed by the name of a target object. The target object could…

  14. Real-time speech gisting for ATC applications

    Science.gov (United States)

    Dunkelberger, Kirk A.

    1995-06-01

    Command and control within the ATC environment remains primarily voice-based. Hence, automatic real time, speaker independent, continuous speech recognition (CSR) has many obvious applications and implied benefits to the ATC community: automated target tagging, aircraft compliance monitoring, controller training, automatic alarm disabling, display management, and many others. However, while current state-of-the-art CSR systems provide upwards of 98% word accuracy in laboratory environments, recent low-intrusion experiments in the ATCT environments demonstrated less than 70% word accuracy in spite of significant investments in recognizer tuning. Acoustic channel irregularities and controller/pilot grammar verities impact current CSR algorithms at their weakest points. It will be shown herein, however, that real time context- and environment-sensitive gisting can provide key command phrase recognition rates of greater than 95% using the same low-intrusion approach. The combination of real time inexact syntactic pattern recognition techniques and a tight integration of CSR, gisting, and ATC database accessor system components is the key to these high phase recognition rates. A system concept for real time gisting in the ATC context is presented herein. After establishing an application context, discussion presents a minimal CSR technology context then focuses on the gisting mechanism, desirable interfaces into the ATCT database environment, and data and control flow within the prototype system. Results of recent tests for a subset of the functionality are presented together with suggestions for further research.

  15. Iconic memory for the gist of natural scenes.

    Science.gov (United States)

    Clarke, Jason; Mack, Arien

    2014-11-01

    Does iconic memory contain the gist of multiple scenes? Three experiments were conducted. In the first, four scenes from different basic-level categories were briefly presented in one of two conditions: a cue or a no-cue condition. The cue condition was designed to provide an index of the contents of iconic memory of the display. Subjects were more sensitive to scene gist in the cue condition than in the no-cue condition. In the second, the scenes came from the same basic-level category. We found no difference in sensitivity between the two conditions. In the third, six scenes from different basic level categories were presented in the visual periphery. Subjects were more sensitive to scene gist in the cue condition. These results suggest that scene gist is contained in iconic memory even in the visual periphery; however, iconic representations are not sufficiently detailed to distinguish between scenes coming from the same category. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. Experiences and perspectives on the GIST patient journey

    Directory of Open Access Journals (Sweden)

    Macdonald N

    2012-03-01

    Full Text Available Nancy Macdonald1, Ari Shapiro1, Christina Bender2, Marc Paolantonio2, John Coombs21Flince Research + Design, New York, NY, 2Novartis Pharmaceuticals, East Hanover, NJ, USAPurpose: The tyrosine kinase inhibitor (TKI imatinib has improved outcomes for patients with unresectable or metastatic gastrointestinal stromal tumors (GIST, and for patients receiving adjuvant therapy following GIST resection. This qualitative study explored the experiences and emotions of patients through GIST diagnosis, treatment initiation, disease control, and in some patients, loss of response and therapy switch.Patients and methods: Ethnographic investigations were conducted, including semi-structured qualitative interviews of patients with resected or metastatic/unresectable GIST and their caregivers, from Canada (n = 15; the United States (n = 10; and Brazil, France, Germany, Russia, and Spain (n = 5 each. Some interviewees also kept 7-day photo journals. Responses were qualitatively analyzed to identify gaps and unmet needs where communication about disease, treatments, and adherence could be effective.Results: Patients shared common experiences during each stage of disease management (crisis, hope, adaptation, new normal, and uncertainty. Patients felt a sense of crisis during diagnosis, followed by hope upon TKI therapy initiation. Over time, they came to adapt to their new lives (new normal with cancer. With each follow-up, patients confronted the uncertainty of becoming TKI resistant and the possible need to switch therapy. During uncertainty many patients sought new information regarding GIST. Cases of disease progression and drug switching caused patients to revert to crisis and restart their emotional journey. Patients with primary or unresectable/metastatic GIST shared similar journeys, especially regarding uncertainty, although differences in the scope and timing of phases were observed. Strategies patients used to remain adherent included obtaining family

  17. Perceived Average Orientation Reflects Effective Gist of the Surface.

    Science.gov (United States)

    Cha, Oakyoon; Chong, Sang Chul

    2018-03-01

    The human ability to represent ensemble visual information, such as average orientation and size, has been suggested as the foundation of gist perception. To effectively summarize different groups of objects into the gist of a scene, observers should form ensembles separately for different groups, even when objects have similar visual features across groups. We hypothesized that the visual system utilizes perceptual groups characterized by spatial configuration and represents separate ensembles for different groups. Therefore, participants could not integrate ensembles of different perceptual groups on a task basis. We asked participants to determine the average orientation of visual elements comprising a surface with a contour situated inside. Although participants were asked to estimate the average orientation of all the elements, they ignored orientation signals embedded in the contour. This constraint may help the visual system to keep the visual features of occluding objects separate from those of the occluded objects.

  18. A gastrointestinal stromal tumor (GIST masquerading as an ovarian mass

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    Beneduce Pasquale

    2004-05-01

    Full Text Available Abstract Background Malignant gastrointestinal stromal tumors (GIST are rare mesenchymal tumors originating in the wall of the gastrointestinal tract. Myogenic gastrointestinal stromal tumor, a distinctive morphologic variant is characterized by an unusually prominent myxoid stromal background. Case presentation We report a case of myxoid variant of GIST in a 42 years old woman presenting as an epigastric mass associated to an ovarian cyst and elevated CA-125. Histologically, the lesions was composed of a proliferation of spindle cells in an abundant myxoid stroma, without evidence of atypia or anaplasia. Immunohistochemical stains showed strong positive staining with muscle actin, positive staining with CD34 and weak positive staining with CD117, while showed negative for S-100. Conclusion At surgery every effort should be made to identify the origin of the tumor. A complete surgical removal of the tumor should be obtained, as this is the only established treatment that offers long term survival.

  19. How Reasoning, Judgment, and Decision Making are Colored by Gist-based Intuition: A Fuzzy-Trace Theory Approach.

    Science.gov (United States)

    Corbin, Jonathan C; Reyna, Valerie F; Weldon, Rebecca B; Brainerd, Charles J

    2015-12-01

    Fuzzy-trace theory distinguishes verbatim (literal, exact) from gist (meaningful) representations, predicting that reliance on gist increases with experience and expertise. Thus, many judgment-and-decision-making biases increase with development, such that cognition is colored by context in ways that violate logical coherence and probability theories. Nevertheless, this increase in gist-based intuition is adaptive: Gist is stable, less sensitive to interference, and easier to manipulate. Moreover, gist captures the functionally significant essence of information, supporting healthier and more robust decision processes. We describe how fuzzy-trace theory accounts for judgment-and-decision making phenomena, predicting the paradoxical arc of these processes with the development of experience and expertise. We present data linking gist memory processes to gist processing in decision making and provide illustrations of gist reliance in medicine, public health, and intelligence analysis.

  20. Análise histológica do trato gastrintestinal de avestruzes jovens (Struthio camelus Linnaeus, 1758

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    Cristina Maria Rodrigues Monteiro

    2009-06-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2009v22n3p149 Aspectos histológicos do trato gastrintestinal do avestruz (Struthio camelus são pouco estudados, portanto, é de interesse desta pesquisa ampliar tais estudos. Para isso foram obtidas amostras de diferentes segmentos do tubo digestório de cinco avestruzes jovens, com idade entre 20 a 30 dias. Com base nos resultados obtidos pudemos concluir que os diferentes segmentos do tubo digestório do avestruz jovem apresenta a mesma estrutura geral de outras aves e mamíferos domésticos, com pequenas diferenças, como ausência de inglúvio e vesícula biliar, intestino grosso maior que o intestino delgado e ceco com propriedades fisiológicas semelhantes ao estômago de ruminantes.  Estas variações são inerentes à espécie ou podem ser decorrentes da idade e hábito alimentar. Esperamos que esta análise contribua para uma melhor compreensão dos processos fisiológicos relacionados à nutrição e ao manejo do avestruz durante seu crescimento.

  1. Pancreatic insulinoma co-existing with gastric GIST in the absence of neurofibromatosis-1

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    O'Sullivan Brendan

    2009-02-01

    Full Text Available Abstract Background Gastrointestinal stromal tumours (GIST frequently occur in patients with neurofibromatosis type 1 (NF-1. It has been reported that GIST may co-exist with pancreatic endocrine tumors but this has only been in association with NF-1. Case presentation A 76 year old woman presented with a 12 month history of hypoglycaemia symptoms. Abdominal CT scan demonstrated a 13 mm insulinoma localized in the tail of her pancreas. She was commenced on diazoxide and later underwent surgery for enucleation of insulinoma when a small ( Conclusion This is the first case report of a pancreatic insulinoma co-existing with a GIST in a patient without NF-1. In addition, we make the first report of rapidly growing cystic GIST recurrence following resection of a primary GIST tumour.

  2. Cyclin H expression is increased in GIST with very-high risk of malignancy

    International Nuclear Information System (INIS)

    Dorn, Julian; Spatz, Hanno; Schmieder, Michael; Barth, Thomas FE; Blatz, Annette; Henne-Bruns, Doris; Knippschild, Uwe; Kramer, Klaus

    2010-01-01

    Risk estimation of gastrointestinal stromal tumours (GIST) is based on tumour size and mitotic rate according to the National Institutes of Health consensus classification. The indication for adjuvant treatment of patients with high risk GIST after R 0 resection with small molecule inhibitors is still a controversial issue, since these patients represent a highly heterogeneous population. Therefore, additional prognostic indicators are needed. Here, we evaluated the prognostic value of cyclin H expression in GIST. In order to identify prognostic factors of GIST we evaluated a single centre cohort of ninety-five GIST patients. First, GISTs were classified with regard to tumour size, mitotic rate and localisation according to the NIH consensus and to three additional suggested risk classifications. Second, Cyclin H expression was analysed. Of ninety-five patients with GIST (53 female/42 male; median age: 66.78a; range 17-94a) risk classification revealed: 42% high risk, 20% intermediate risk, 23% low risk and 15% very low risk GIST. In patients with high risk GIST, the expression of cyclin H was highly predictive for reduced disease-specific survival (p = 0.038). A combination of cyclin H expression level and high risk classification yielded the strongest prognostic indicator for disease-specific and disease-free survival (p ≤ 0.001). Moreover, in patients with tumour recurrence and/or metastases, cyclin H positivity was significantly associated with reduced disease-specific survival (p = 0.016) regardless of risk-classification. Our data suggest that, in addition to high risk classification, cyclin H expression might be an indicator for 'very-high risk' GIST

  3. Implicit and explicit forgetting: when is gist remembered?

    Science.gov (United States)

    Dorfman, J; Mandler, G

    1994-08-01

    Recognition (YES/NO) and stem completion (cued: complete with a word from the list; and uncued: complete with the first word that comes to mind) were tested following either semantic or non-semantic processing of a categorized input list. Item/instance information was tested by contrasting target items from the input list with new items that were categorically related to them; gist/categorical information was tested by comparing target items semantically related to the input items with unrelated new items. For both recognition and stem completion, regardless of initial processing condition, item information decayed rapidly over a period of one week. Gist information was maintained over the same period when initial processing was semantic but only in the cued condition for completion. These results are discussed in terms of dual process theory, which postulates activation/integration of a representation as primarily relevant to implicit item information and elaboration of a representation as mainly relevant to semantic (i.e. categorical) information.

  4. Dinâmica dos nutrientes no trato gastrintestinal de novilhos holandeses alimentados com dietas à base de cana-de-açúcar Dynamic of the nutrients in the gastrintestinal tract of holstein steers fed sugar cane based diets

    Directory of Open Access Journals (Sweden)

    Elzânia Sales Pereira

    2003-12-01

    Full Text Available Foram objetivos deste trabalho validar as predições com base nas estimativas da dinâmica ruminal e pós-ruminal dos nutrientes e do crescimento microbiano no rúmen, usando as equações que compõem o submodelo Cornell relativo ao trato gastrintestinal. Foram utilizados quatro novilhos Holandês-Zebu com peso médio de 300 kg, canulados no rúmen e abomaso, distribuídos em delineamento quadrado latino 4 x 4. Os animais experimentais foram alimentados com rações à base de cana-de-açúcar, suplementada com duas fontes de nitrogênio (uréia ou cama de frango e dois níveis de levedura (0 ou 10 g dia-1, constituindo-se esquema fatorial 2 x 2. A FDN indigestível e a FDN da cana-de-açúcar complexada com cromo foram usadas como indicadores interno e externo, para estimar a produção fecal diária e a taxa de passagem de partículas no rúmen. A dinâmica dos nutrientes baseou-se nas determinações do fluxo de nitrogênio total e do fluxo de nitrogênio de origem bacteriana no abomaso e dos carboidratos totais digeridos no rúmen. A produção microbiana não foi influenciada pelas fontes nitrogenadas e pela adição de Saccharomyces cerevisiae. O Sistema Cornell superestimou os carboidratos totais degradados no rúmen, o fluxo de nitrogênio de origem microbiana e subestimou o fluxo de N total no abomaso.The objectives of this work were to validate the predictions based on the estimates of the ruminal nutrient dynamics and on the microbial growth in the rumen, using equations of the Cornell Submodel system relative to the gastrintestinal tract. Four Holstein - Zebu steers, with 300 kg live weight, rumen and abomasal cannulated were allotted to 4x4 latin square design. The experimental animals received sugar cane based diets, supplemented with two nitrogen sources (urea or poultry litter and two yeast levels (0 or 10 g / d, being constituted 2x2 factorial arrangement. The indigestible neutral detergent fiber (NDF and chromium mordant

  5. Aspectos clínicos, morfológicos e imuno-histoquímicos da pitiose gastrintestinal canina

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    Maria E. Trost

    2009-08-01

    Full Text Available Através de um estudo retrospectivo dos casos de biópsias e necropsias de cães recebidos no Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria, constatou-se a ocorrência de dois casos confirmados e de quatro casos suspeitos de pitiose gastrintestinal canina. Os dois casos diagnosticados e publicados tiveram a etiologia confirmada através da cultura e indução de zoosporogênese ou por nested-PCR. Neste estudo utilizou-se a técnica de imuno-histoquímica com anticorpo policlonal anti-Pythium insidiosum para confirmação da etiologia dos quatro casos suspeitos. A epidemiologia, sinais clínicos, lesões macroscópicas e microscópicas, características histoquímicas e imuno-histoquímicas e diagnósticos diferenciais são relatados e discutidos.Four suspect and two confirmed cases of gastrointestinal pythiosis were found in a retrospective study of biopsy and necropsy cases of dogs received in the Laboratório de Patologia Veterinária at the Universidade Federal de Santa Maria. The two diagnosed and published cases have had the etiology confirmed by culture and zoosporogenesis induction or by nested-PCR. On this study, the etiologic diagnosis of four suspect cases was confirmed by immunohistochemistry using anti-Pythium insidiosum policlonal antibody. Epidemiology, clinical signs, gross and microscopic lesions, histochemistry, immunohistochemistry, and differential diagnoses are reported and discussed.

  6. Racing with friends: Resistance to peer influence, gist and specific risk beliefs.

    Science.gov (United States)

    Mirman, Jessica H; Curry, Allison E

    2016-11-01

    Studies assessing young drivers' risk appraisals with their driving behavior have shown both positive and inverse associations, possibly due to differences in survey items that cue gist appraisals about risk (i.e., beliefs that are focused on meaning) or specific appraisals (i.e., beliefs that are focused on discrete instances). Prior research has indicated that gist-based reasoning is protective against engaging in risk behavior and that use of gist appraisals increases with development. Additionally, although much of adolescents' risk-taking occurs in groups, almost no research examines how adolescents' resistance to peer influence may relate to their specific and gist beliefs about socially-bound risk behavior, as well as their future engagement in such behavior. One hundred and thirty-two adolescent drivers participated in a prospective self-report study on racing behavior. Surveys measured specific and gist risk appraisals, resistance to peer influence, and racing behavior at two time points three months apart. We hypothesized that stronger specific appraisals would be associated with greater likelihood of racing, and stronger gist appraisals would be protective. Further, we hypothesized that resistance to peer influence would be positively associated with gist appraisals and negatively associated with specific risk appraisals; and would also be inversely associate with racing. Specific risk appraisals and gist appraisals were predictive of racing behavior as hypothesized. Resistance to peer influence did not predict racing, but was associated with each type of risk appraisal as predicted at Time 1, although the association between specific risk and resistance to peer influence was non-significant at the second time point. Gist beliefs and the ability to resist influence from friends might be indicative of an underlying strength of one's own beliefs about the self as a non-risk taking person who stands up for his or her beliefs, which is protective against

  7. Effects of Higher-order Cognitive Strategy Training on Gist Reasoning and Fact Learning in Adolescents

    Directory of Open Access Journals (Sweden)

    Jacquelyn F Gamino

    2010-12-01

    Full Text Available Improving the reasoning skills of adolescents across the United States has become a major concern for educators and scientists who are dedicated to identifying evidence-based protocols to improve student outcome. This small sample randomized, control pilot study sought to determine the efficacy of higher-order cognitive training on gist-reasoning and fact-learning in an inner-city public middle school. The study compared gist-reasoning and fact-learning performances after training in a smaller sample when tested in Spanish, many of the students’ native language, versus English. The 54 eighth grade students who participated in this pilot study were enrolled in an urban middle school, predominantly from lower socio-economic status families, and were primarily of minority descent. The students were randomized into one of three groups, one that learned cognitive strategies promoting abstraction of meaning, a group that learned rote memory strategies, or a control group to ascertain the impact of each program on gist-reasoning and fact-learning from text-based information. We found that the students who had cognitive strategy instruction that entailed abstraction of meaning significantly improved their gist-reasoning and fact-learning ability. The students who learned rote memory strategies significantly improved their fact-learning scores from a text but not gist-reasoning ability. The control group showed no significant change in either gist-reasoning or fact-learning ability. A trend toward significant improvement in overall reading scores for the group that learned to abstract meaning as well as a significant correlation between gist-reasoning ability and the critical thinking on a state-mandated standardized reading test was also found. There were no significant differences between English and Spanish performance of gist reasoning and fact learning. Our findings suggest that teaching higher-order cognitive strategies facilitates gist

  8. Beyond the GIST: Mesenchymal Tumors of the Stomach

    Science.gov (United States)

    Menias, Christine O.; Gaballah, Ayman H.; Shroff, Stuti; Taggart, Melissa W.; Garg, Naveen; Elsayes, Khaled M.

    2013-01-01

    Intramural gastric masses arise in the wall of the stomach (generally within the submucosa or muscularis propria), often with intact overlying mucosa. These tumors are typically mesenchymal in origin and have overlapping radiologic appearances. A combination of features such as location, attenuation, enhancement, and growth pattern may suggest one diagnosis over another. Gastrointestinal stromal tumors (GISTs) account for the majority of intramural tumors and can vary widely in appearance, from small intraluminal lesions to exophytic masses that protrude into the peritoneal cavity, commonly with areas of hemorrhage or necrosis. A well-circumscribed mass measuring −70 to −120 HU is a lipoma. Leiomyomas usually manifest as low-attenuation masses at the gastric cardia. Homogeneous attenuation is a noteworthy characteristic of schwannomas, particularly for larger lesions that might otherwise be mistaken for GISTs. A hypervascular mass in the antrum is a common manifestation of glomus tumors. Hemangiomas are also hypervascular but often manifest in childhood. Inflammatory fibroid polyps usually arise as a polypoid mass in the antrum. Inflammatory myofibroblastic tumors are infiltrative neoplasms with a propensity for local recurrence. Plexiform fibromyxomas are rare, usually antral tumors. Carcinoid tumors are epithelial in origin, but often submucosal in location, and therefore should be distinguished from other intramural lesions. Multiple carcinoid tumors are associated with hypergastrinemia, either in the setting of chronic atrophic gastritis or Zollinger-Ellison syndrome. Sporadic solitary carcinoid tumors not associated with hypergastrinemia have a higher rate of metastasis. Histopathologic analysis, including immunohistochemistry, is usually required for diagnosis of intramural masses. © RSNA, 2013 PMID:24108557

  9. Endometriose do trato gastrintestinal: correlações clínicas e laparoscópicas Endometriosis of the gastrointestinal tract: clinical and laparoscopic correlations

    Directory of Open Access Journals (Sweden)

    Univaldo Etsuo Sagae

    2007-12-01

    Full Text Available Neste estudo, quarenta pacientes selecionadas com endometriose pélvica e utilizando do método videolaparoscópico de corrida dos órgãos peritoneais na endometriose (COPE, puderam verificar se suas queixas encontram-se correlacionadas aos achados de lesões no trato gastrintestinal. O estudo avaliou 21 pacientes com e 19 pacientes sem sinais e sintomas gastrintestinais, visando estabelecer: associações e correlações entre os parâmetros clínicos que sinalizam a presença de focos endometrióticos e as localizações das lesões em cada segmento do trato gastrintestinal (TGI e a correlação entre o estadiamento da endometriose (ASRM, 1996 e o comprometimento intestinal. A pesquisa atestou, de modo significativo, a correlação entre a presença dos sintomas gastrintestinais em conseqüência das lesões no trato gastrintestinal. Os sinais e sintomas gastrintestinais significativamente relacionados com a presença de endometriose ginecológica localizada no segmento retossigmóide e/ou íleo e com comprometimento do trato gastrintestinal foram: o puxo e o tenesmo cíclico, dor em cólica cíclica, obstipação cíclica, diarréia cíclica, dor acíclica, fezes afiladas e o sangramento intestinal cíclico. O estádio IV (ASRM correlacionou-se com a presença de endometriose no trato gastrintestinal. O presente estudo demonstrou a correlação positiva dos sinais e sintomas gastrointestinais e ginecológicos e o estadiamento da doença ginecológica com o comprometimento gastrointestinal pela doença.The peritoneal organs of 40 patients with pelvic endometriosis were scanned for endometriosis in this study by the videolaparoscopic method to verify the relation of their complaints with lesions found in the gastrointestinal tract. Twenty one of these patients who had gastrointestinal signs and symptoms and 19 who did not, were evaluated in order to establish associations and correlations between clinical parameters pointing to endometriotic

  10. RKAS loodab müügist saada 400 miljonit / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2008-01-01

    Riigi Kinnisvara AS on kuulutanud enampakkumise välja neljale hoonestatud kinnistule, augustikuu jooksul peaks lisanduma veel seitse objekti. Kokku loodab RKAS müügist saada pisut üle 409 miljoni krooni

  11. Recommendations for diagnostics and therapy of gastrointestinal stromal tumors (GIST) in 2010

    International Nuclear Information System (INIS)

    Rutkowski, P.; Kulig, J.; Osuch, C.

    2011-01-01

    Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Over the last years advances in the understanding of the molecular mechanisms of GIST pathogenesis have resulted in the emerging of GIST as a distinct sarcoma entity. This paper presents the guidelines for diagnostics and therapy of these tumors based on scientific research and experts' experience, These guidelines are commonly accepted and worthy of recommendation. Overexpression of the KIT receptor, as a consequence of mutation of the KIT protooncogene is highly specific for GIST and enables immunohistochemical detection staining (CD117) in tumor specimens. It is the most important criterion in microscopic diagnostics and for indicating treatment with small-molecule tyrosine kinase inhibitors. Sending material for molecular analysis is strongly recommended (for KIT and PDGFRA genotyping). Radical surgery is still the mainstay treatment for primary, localized, resectable GISTs, although although a significant ratio of patients after potentially curative operations develop recurrent or metastatic disease. In inoperable/metastatic lesions the treatment of choice is a tyrosine kinase inhibitor - imatynib mesylate - the first effective systemic therapy in advanced CD117(+) GIST. The recommended initial dose should be 400 mg daily (800 mg for exon 9 KIT mutants). Treatment monitoring should be based on serial computed tomography imaging of the abdominal cavity with the assessment of changes of tumor size and density. In case of disease progression the increase of imatynib dose to 800 mg daily is recommended and - if progression maintains - sunitinib in the initial dose of 50 mg daily should be introduced. Clinical trials evaluating the role of surgery combined with imatynib and the efficacy of other molecular targeted drugs in resistant cases are ongoing. Existing data indicate the beneficial role of adjuvant imatynib therapy in terms of relapse-free survival

  12. Sleep Supports the Slow Abstraction of Gist from Visual Perceptual Memories.

    Science.gov (United States)

    Lutz, Nicolas D; Diekelmann, Susanne; Hinse-Stern, Patricia; Born, Jan; Rauss, Karsten

    2017-02-17

    Sleep benefits the consolidation of individual episodic memories. In the long run, however, it may be more efficient to retain the abstract gist of single, related memories, which can be generalized to similar instances in the future. While episodic memory is enhanced after one night of sleep, effective gist abstraction is thought to require multiple nights. We tested this hypothesis using a visual Deese-Roediger-McDermott paradigm, examining gist abstraction and episodic-like memory consolidation after 20 min, after 10 hours, as well as after one year of retention. While after 10 hours, sleep enhanced episodic-like memory for single items, it did not affect gist abstraction. One year later, however, we found significant gist knowledge only if subjects had slept immediately after encoding, while there was no residual memory for individual items. These findings indicate that sleep after learning strengthens episodic-like memories in the short term and facilitates long-term gist abstraction.

  13. Get the gist? The effects of processing depth on false recognition in short-term and long-term memory

    OpenAIRE

    Flegal, Kristin E.; Reuter-Lorenz, Patricia A.

    2014-01-01

    Gist-based processing has been proposed to account for robust false memories in the converging-associates task. The deep-encoding processes known to enhance verbatim memory also strengthen gist memory and increase distortions of long-term memory (LTM). Recent research has demonstrated that compelling false memory illusions are relatively delay-invariant, also occurring under canonical short-term memory (STM) conditions. To investigate the contributions of gist to false memory at short and lon...

  14. Características das carcaças, biometria do trato gastrintestinal, tamanho dos órgãos internos e conteúdo gastrintestinal de bovinos F1 Simental x Nelore alimentados com dietas contendo vários níveis de concentrado

    Directory of Open Access Journals (Sweden)

    Ferreira Marcelo de Andrade

    2000-01-01

    Full Text Available A utilização de diferentes níveis de concentrado na ração (25; 37,5; 50; 62,5; e 75% foi avaliada sobre as características da carcaça, o peso dos compartimentos do trato gastrintestinal, o peso dos órgãos internos e o conteúdo do trato gastrintestinal, de 24 bovinos mestiços Simental x Nelore, não-castrados, com 17 meses de idade e peso vivo médio de 354 kg. Os animais foram abatidos quando atingiram 500 kg de peso vivo. Após o resfriamento, as carcaças foram avaliadas qualitativa (área de olho de lombo e quantitativamente (medições, rendimentos e cortes básicos. O rendimento da carcaça e dos cortes básicos, a área de olho de lombo e as proporções de músculo e gordura não foram influenciados pelos níveis de concentrado, enquanto o comprimento de carcaça diminuiu linearmente com o aumento do nível de concentrado. O conteúdo do trato gastrintestinal diminuiu linearmente com a adição de concentrado na ração. Não houve efeito dos níveis de concentrado nos pesos de coração, pulmão e rúmen-retículo. Os pesos de fígado, rins, baço, abomaso, intestino delgado e gordura interna aumentaram e o do omaso diminuiu linearmente com a adição de concentrado na dieta.

  15. Initial evaluation of an interactive test of sentence gist recognition.

    Science.gov (United States)

    Tye-Murray, N; Witt, S; Castelloe, J

    1996-12-01

    The laser videodisc-based Sentence Gist Recognition (SGR) test consists of sets of topically related sentences that are cued by short film clips. Clients respond to test items by selecting picture illustrations and may interact with the talker by using repair strategies when they do not recognize a test item. The two experiments, involving 40 and 35 adult subjects, respectively, indicated that the SGR may better predict subjective measures of speechreading and listening performance than more traditional audiologic sentence and nonsense syllable tests. Data from cochlear implant users indicated that the SGR accounted for a greater percentage of the variance for selected items of the Communication Profile for the Hearing-Impaired and the Speechreading Questionnaire for Cochlear-Implant Users than two other audiologic tests. As in previous work, subjects were most apt to ask the talker to repeat an utterance that they did not recognize than to ask the talker to restructure it. It is suggested that the SGR may reflect the interactive nature of conversation and provide a simulated real-world listening and/or speechreading task. The principles underlaying this test are consistent with the development of other computer technologies and concepts, such as compact discinteractive and virtual reality.

  16. Aspectos anátomo-radiográficos e tempo de trânsito gastrintestinal em jacaré tinga Caiman crocodilus crocodilus (Linnaeus, 1758 (Crocodylia, Alligatoridae

    Directory of Open Access Journals (Sweden)

    Heloisa Castro Pereira

    2014-03-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2014v27n3p149 O interesse pela criação de jacarés em cativeiro tem aumentado no Brasil, no entanto, faltam estudos aprofundados sobre o tipo e a frequência de alimentação adequada destes répteis em cativeiro. Objetivou-se determinar os aspectos anátomo-radiográficos e o tempo de trânsito gastrintestinal do Caiman crocodilus crocodilus por meio de radiografias contrastadas. Os dez jacarés, cinco machos e cinco fêmeas, foram contidos fisicamente para a administração, via sonda orogástrica, de 10 ml/kg de suspensão de sulfato de bário e óleo mineral, na proporção de 70%: 30%, respectivamente. As radiografias foram realizadas em projeção dorso-ventral nos tempos de cinco minutos, e seis, 24, 30, 48, 54, 72, 80, 96, 104, 120, 130, 144 e 150 h após a administração do contraste. A técnica utilizada permitiu a visibilização da passagem do contraste, além de determinar o tempo de trânsito gastrintestinal em jacaré tinga. Verificou-se que a média do tempo de passagem do contraste pelo trato digestório desta espécie foi de 117 ± 29,6 h para fêmeas e 86,4 ± 21,5 h para os machos.

  17. The neural correlates of gist-based true and false recognition

    Science.gov (United States)

    Gutchess, Angela H.; Schacter, Daniel L.

    2012-01-01

    When information is thematically related to previously studied information, gist-based processes contribute to false recognition. Using functional MRI, we examined the neural correlates of gist-based recognition as a function of increasing numbers of studied exemplars. Sixteen participants incidentally encoded small, medium, and large sets of pictures, and we compared the neural response at recognition using parametric modulation analyses. For hits, regions in middle occipital, middle temporal, and posterior parietal cortex linearly modulated their activity according to the number of related encoded items. For false alarms, visual, parietal, and hippocampal regions were modulated as a function of the encoded set size. The present results are consistent with prior work in that the neural regions supporting veridical memory also contribute to false memory for related information. The results also reveal that these regions respond to the degree of relatedness among similar items, and implicate perceptual and constructive processes in gist-based false memory. PMID:22155331

  18. Viisnurk saab üksuste müügist heal juhul 170 miljonit krooni / Annika Matson

    Index Scriptorium Estoniae

    Matson, Annika, 1976-

    2004-01-01

    AS Viisnurk müüb ehitus- ja spordikaupade divisjonid, liimpuiduvabriku ning vabrikualuse maa. Viisnurga endine tegevjuht Meelis Kukk ning konkureerivate ettevõtete esindajad prognoosivad müügist saadavat tulu. Diagramm: Suurimat tulu loodetakse kasumis ehitusmaterjalide tootmise müügist. Vt. samas: Adrenaliini armastav investor võiks Viisnurga aktsiat osta

  19. Tumor misto de células musculares lisas e do estroma endometrial uterino: relato de caso Mixed endometrial stromal and smooth muscle tumor of the uterus: case report

    Directory of Open Access Journals (Sweden)

    Luiz Gustavo Oliveira Brito

    2012-12-01

    Full Text Available Os tumores mistos de células musculares lisas e do estroma endometrial uterino, caracterizados pela presença de componentes de ambas as linhagens, coexistindo em proporções quase equivalentes, são neoplasmas raros. Possuem potencial biológico incerto e se comportam de acordo com o componente estromal. A imuno-histoquímica é uma grande aliada no diagnóstico microscópico, pois a clínica e os exames de imagem não ajudam a diferenciá-los de outras doenças uterinas. Descrevemos o caso de uma paciente cuja hipótese diagnóstica era de leiomioma uterino e que, após cirurgia, foi diagnosticada pelo estudo anatomopatológico como tumor misto de células musculares lisas e do estroma endometrial uterino.Mixed tumors of uterine smooth muscle and endometrial stromal cells, which are characterized by the presence of components from both cell lineages with similar proportions, are rare neoplasms. Their biological potential is uncertain, and they behave according to the stromal component. Immunohistochemistry is an important ally in microscopic diagnosis, because symptoms and imaging exams do not help in the differentiation from other uterine diseases. We describe a case of a patient who had been previously diagnosed with uterine leiomyoma, and after surgery, the anatomopathological study revealed a mixed tumor of uterine smooth muscle and endometrial stromal cells.

  20. Laparoscopic total gastrectomy for a giant gastrointestinal stromal tumor (GIST) with acute massive gastrointestinal bleeding: a case report.

    Science.gov (United States)

    Kermansaravi, Mohammad; Rokhgireh, Samaneh; Darabi, Sattar; Pazouki, Abdolreza

    2017-09-01

    Gastrointestinal stromal tumors (GISTs) include 80% of gastrointestinal mesenchymal tumors that originate from interstitial Cajal cells and include 0.1-3% of GI malignancies, and the stomach is the most commonly involved organ. The only potentially curative treatment is surgical resection with clear margins. Although laparoscopic resection of small GISTs is a standard treatment, there is controversy about laparoscopic surgical resection for large and giant GISTs. A 52-year-old woman, a known case of large GIST of the stomach that was under neoadjuvant imatinib therapy, was admitted to the emergency department due to acute massive gastrointestinal bleeding (GIB). The patient underwent laparoscopic total gastrectomy and received adjuvant imatinib after surgery. Laparoscopic resection is a safe and feasible method in large and giant GISTs with oncologic and long-term outcomes comparable to open surgery, and with better short-term outcomes.

  1. The Relationship Between Confrontation Naming and Story Gist Production in Aphasia.

    Science.gov (United States)

    Richardson, Jessica D; Dalton, Sarah Grace; Fromm, Davida; Forbes, Margaret; Holland, Audrey; MacWhinney, Brian

    2018-03-01

    The purpose of this study was to examine the relationship between picture naming performance and the ability to communicate the gist, or essential elements, of a story. We also sought to determine if this relationship varied according to Western Aphasia Battery-Revised (WAB-R; Kertesz, 2007) aphasia subtype. Demographic information, test scores, and transcripts of 258 individuals with aphasia completing 3 narrative tasks were retrieved from the AphasiaBank database. Narratives were subjected to a main concept analysis to determine gist production. A correlation analysis was used to investigate the relationship between naming scores and main concept production for the whole group of persons with aphasia and for WAB-R subtypes separately. We found strong correlations between naming test scores and narrative gist production for the large sample of persons with aphasia. However, the strength of the correlations varied by WAB-R subtype. Picture naming may accurately predict gist production for individuals with Broca's and Wernicke's aphasia, but not for other WAB-R subtypes. Given the current reprioritization of outcome measurement, picture naming may not be an appropriate surrogate measure for functional communication for all persons with aphasia. https://doi.org/10.23641/asha.5851848.

  2. Evidence mapping based on systematic reviews of therapeutic interventions for gastrointestinal stromal tumors (GIST

    Directory of Open Access Journals (Sweden)

    Mónica Ballesteros

    2017-09-01

    Full Text Available Abstract Background Gastrointestinal Stromal Tumours (GISTs are the most common mesenchymal tumours. Currently, different pharmacological and surgical options are used to treat localised and metastatic GISTs, although this research field is broad and the body of evidence is scattered and expanding. Our objectives are to identify, describe and organise the current available evidence for GIST through an evidence mapping approach. Methods We followed the methodology of Global Evidence Mapping (GEM. We searched Pubmed, EMBASE, The Cochrane Library and Epistemonikos in order to identify systematic reviews (SRs with or without meta-analyses published between 1990 and March 2016. Two authors assessed eligibility and extracted data. Methodological quality of the included systematic reviews was assessed using AMSTAR. We organised the results according to identified PICO questions and presented the evidence map in tables and a bubble plot. Results A total of 17 SRs met eligibility criteria. These reviews included 66 individual studies, of which three quarters were either observational or uncontrolled clinical trials. Overall, the quality of the included SRs was moderate or high. In total, we extracted 14 PICO questions from them and the corresponding results mostly favoured the intervention arm. Conclusions The most common type of study used to evaluate therapeutic interventions in GIST sarcomas has been non-experimental studies. However, the majority of the interventions are reported as beneficial or probably beneficial by the respective authors of SRs. The evidence mapping is a useful and reliable methodology to identify and present the existing evidence about therapeutic interventions.

  3. Emergency surgery due to complications during molecular targeted therapy in advanced gastrointestinal stromal tumors (GIST)

    International Nuclear Information System (INIS)

    Rutkowski, P.; Nowecki, Z. I.; Dziewirski, W.; Ruka, W.; Siedlecki, J. A.; Grzesiakowska, U.

    2010-01-01

    Aim. The aim of the study was to assess the frequency and results of disease/treatment-related emergency operations during molecular targeted therapy of advanced gastrointestinal stromal tumors (GISTs). Methods. We analyzed emergency operations in patients with metastatic/inoperable GISTs treated with 1 st -line imatinib - IM (group I: 232 patients; median follow-up time 31 months) and 2 nd -line sunitinib - SU (group II: 43 patients; median follow-up 13 months; 35 patients in trial A6181036) enrolled into the Polish Clinical GIST Registry. Results. In group I 3 patients (1.3%) underwent emergency surgery due to disease/treatment related complications: one due to bleeding from a ruptured liver tumor (1 month after IM onset) and two due to bowel perforation on the tumor with subsequent intraperitoneal abscess (both 2 months after IM onset). IM was restarted 5-8 days after surgery and no complications in wound healing were observed. In group II 4 patients (9.5%) underwent emergency operations due to disease/treatment related complications: three due to bowel perforations on the tumor (2 days, 20 days and 10 months after SU onset; 1 subsequent death) and one due to intraperitoneal bleeding from ruptured, necrotic tumor (3.5 months after SU start). SU was restarted 12-18 days after surgery and no complications in wound healing were observed. Conclusions. Emergency operations associated with disease or therapy during imatinib treatment of advanced GISTs are rare. The frequency of emergency operations during sunitinib therapy is considered to be higher than during first line therapy with imatinib which may be associated with more advanced and more resistant disease or to the direct mechanism of sunitinib action, i.e. combining cytotoxic and antiangiogenic activity and thus leading to dramatic tumor response. Molecular targeted therapy in GISTs should always be conducted in cooperation with an experienced surgeon. (authors)

  4. Clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs.

    Science.gov (United States)

    Kataoka, Mikinori; Kawai, Takashi; Ikemiyagi, Hidekazu; Fujii, Takashi; Fukuzawa, Mari; Fukuzawa, Masakatsu; Kubota, Keisuke; Yoshida, Masashi; Suzuki, Shinji; Kitajima, Masaki

    2013-01-01

    We previously reported that safety and efficacy of mucosal cutting biopsy for diagnosing included 2 cm or less gastric GISTs. However, there have been no reports stating the clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs. The aim of our study is to investigate the clinicopathological characteristic and clinical handling of the patients with 2 cm or less gastric GISTs. The 19 patients diagnosed with GIST by mucosal cutting biopsy were divided into 2 groups: Group I; subjects were GISTs with 2 cm or less, Group II; subjects were GISTs >2 cm. We compared the 2 groups in terms of mean age, tumor size, tumor site, histopathological risk grade. In cases that underwent surgery with a diagnosis of GIST, we compared the pre- and postoperative histopathological diagnosis, and the histopathlogical risk grade within each group. The mean age and tumor size were significantly higher in Group I than in Group II. Meanwhile, there were no significant differences between the 2 groups, sex ratio, tumor site. All lesions were at histopathological risk grade at very low risk and low risk respectively. In 17 patients with GIST who underwent surgery, the histopathological diagnoses, immunostaining were in agreement with those from the mucosal cutting biopsy specimens in all cases, but mitotic count of one patient was not in agreement in group II. The 2 cm or less gastric GISTs diagnosed with histpathlogical very low risk can be considered acceptable to follow-up.

  5. Recurrent Lower Gastrointestinal Bleeding: Ileal GIST Diagnosed by Video Capsule Endoscopy—A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Jie Ling

    2013-01-01

    Full Text Available Introduction. Gastrointestinal stromal tumor (GIST in the ileum is an extremely rare cause of recurrent lower gastrointestinal bleeding (GIB. Case Report. An 89-year-old man was admitted with melana. He had extensive PMH of CAD post-CABG/AICD, AAA repair, chronic anemia, myelodysplastic syndrome, lung cancer after resection, and recurrent GIB. Prior EGDs, colonoscopies, and upper device-assisted enteroscopy showed duodenal ulcer, A-V malformation s/p cauterization, and angioectasia. On admission, Hb was 6.0 g/dL. An endoscopic capsule study showed an ulcerated tumor in the ileum. CT showed no distant metastasis. The lesion was resected successfully and confirmed as a high-grade GIST. The patient was discharged with no further bleeding. Discussion. Early diagnosis for patients with ileal GIST is often challenging. Video capsule endoscopy and double balloon enteroscopy could be useful diagnostic tools. Surgical removal is the first line for a resectable GIST. Imatinib has become the standard therapy. Conclusion. This is a unique case of an ileal GIST in a patient with recurrent GIB which was diagnosed by video capsule. Complicated medical comorbidities often lead to a significant delay in diagnosis. Therefore, we recommend that if GIB does not resolve after appropriate treatments for known causes, the alternative diagnosis for occult GIB must be considered, including malignancy such as GIST.

  6. Predictive value and modeling analysis of MSCT signs in gastrointestinal stromal tumors (GISTs) to pathological risk degree.

    Science.gov (United States)

    Wang, J-K

    2017-03-01

    By analyzing MSCT (multi-slice computed tomography) signs with different risks in gastrointestinal stromal tumors, this paper aimed to discuss the predictive value and modeling analysis of MSCT signs in GISTs (gastrointestinal stromal tumor) to pathological risk degree. 100 cases of primary GISTs with abdominal and pelvic MSCT scan were involved in this study. All MSCT scan findings and enhanced findings were analyzed and compared among cases with different risk degree of pathology. Then GISTs diagnostic model was established by using support vector machine (SVM) algorithm, and its diagnostic value was evaluated as well. All lesions were solitary, among which there were 46 low-risk cases, 24 medium-risk cases and 30 high-risk cases. For all high-risk, medium-risk and low-risk GISTs, there were statistical differences in tumor growth pattern, size, shape, fat space, with or without calcification, ulcer, enhancement method and peritumoral and intratumoral vessels (pvalue at each period (plain scan, arterial phase, venous phase) (p>0.05). The apparent difference lied in plain scan, arterial phase and venous phase for each risk degree. The diagnostic accuracy of SVM diagnostic model established with 10 imaging features as indexes was 70.0%, and it was especially reliable when diagnosing GISTs of high or low risk. Preoperative analysis of MSCT features is clinically significant for its diagnosis of risk degree and prognosis; GISTs diagnostic model established on the basis of SVM possesses high diagnostic value.

  7. Long-term memory for the emotional gist and the emotional essence of an experience.

    Science.gov (United States)

    Safer, Martin A; Breslin, Carolyn W; Boesch, Richard P; Cerqueira, Renata

    2007-11-01

    We investigated accuracy in recalling past emotional behaviours and emotionality. Male couples discussed the history of their relationship, and coders rated the extent to which each partner engaged in behaviours such as complimenting or criticising. These ratings were combined into dimensions representing the deeper, emotional essence of that partner's discussion (expressions of We-ness, Fondness, Negativity, and Disappointment). Four years later, participants accurately recalled some of their own and some of their partner's emotional gist-level behaviours, but their answers indicated that they also remembered the emotional essence of the conversation. We conclude that individuals can retain the emotional essence of an experience for a long time, and that they may use this memory to infer, in part, gist-level details of the experience.

  8. Bridging Learning Communities Through Experiential Learning with GIST: 2Y College Experience

    Science.gov (United States)

    Sorey, N.; Phillips, C. D.

    2017-12-01

    This study reviews successes of community engagement through experiential learning with GIST across academic disciplines that leverage topics with technology and community relationships throughout a two-year campus and the community at large. This approach allowed for a diversification of populations reached through college student engagement and community outreach efforts. Technological frameworks and development of best practice resources to support students and faculty were shown to increase the capacity for undergraduate research experiences, K12 short course offerings during the summer, and the formation of a STEM-focused student organization. The RSO has participated in activities that include educational technology development, participating in the growth and development of the area's maker movement community, and geoscience outreach and education. Development of the program thus far and lessons learned have resulted in a proposal for an areal-based informal pathway linking the K12 community to area colleges by integrating geoscience outreach with GIST through the maker movement.

  9. Revisiting a dogma: similar survival of patients with small bowel and gastric GIST. A population-based propensity score SEER analysis.

    Science.gov (United States)

    Guller, Ulrich; Tarantino, Ignazio; Cerny, Thomas; Ulrich, Alexis; Schmied, Bruno M; Warschkow, Rene

    2017-01-01

    The objective of the present analysis was to assess whether small bowel gastrointestinal stromal tumor (GIST) is associated with worse cancer-specific survival (CSS) and overall survival (OS) compared with gastric GIST on a population-based level. Data on patients aged 18 years or older with histologically proven GIST was extracted from the SEER database from 1998 to 2011. OS and CSS for small bowel GIST were compared with OS and CSS for gastric GIST by application of adjusted and unadjusted Cox regression analyses and propensity score analyses. GIST were located in the stomach (n = 3011, 59 %), duodenum (n = 313, 6 %), jejunum/ileum (n = 1288, 25 %), colon (n = 139, 3 %), rectum (n = 172, 3 %), and extraviscerally (n = 173, 3 %). OS and CSS of patients with GIST in the duodenum [OS, HR 0.95, 95 % confidence interval (CI) 0.76-1.19; CSS, HR 0.99, 95 % CI 0.76-1.29] and in the jejunum/ileum (OS, HR 0.97, 95 % CI 0.85-1.10; CSS, HR = 0.95, 95 % CI 0.81-1.10) were similar to those of patients with gastric GIST in multivariate analyses. Conversely, OS and CSS of patients with GIST in the colon (OS, HR 1.40; 95 % CI 1.07-1.83; CSS, HR 1.89, 95 % CI 1.41-2.54) and in an extravisceral location (OS, HR 1.42, 95 % CI 1.14-1.77; CSS, HR = 1.43, 95 % CI 1.11-1.84) were significantly worse than those of patients with gastric GIST. Contrary to common belief, OS and CSS of patients with small bowel GIST are not statistically different from those of patients with gastric GIST when adjustment is made for confounding variables on a population-based level. The prognosis of patients with nongastric GIST is worse because of a colonic and extravisceral GIST location. These findings have implications regarding adjuvant treatment of GIST patients. Hence, the dogma that small bowel GIST patients have worse prognosis than gastric GIST patients and therefore should receive adjuvant treatment to a greater extent must be revisited.

  10. Gist-based conceptual processing of pictures remains intact in patients with amnestic mild cognitive impairment.

    Science.gov (United States)

    Deason, Rebecca G; Hussey, Erin P; Budson, Andrew E; Ally, Brandon A

    2012-03-01

    The picture superiority effect, better memory for pictures compared to words, has been found in young adults, healthy older adults, and, most recently, in patients with Alzheimer's disease and mild cognitive impairment. Although the picture superiority effect is widely found, there is still debate over what drives this effect. One main question is whether it is enhanced perceptual or conceptual information that leads to the advantage for pictures over words. In this experiment, we examined the picture superiority effect in healthy older adults and patients with amnestic mild cognitive impairment (MCI) to better understand the role of gist-based conceptual processing. We had participants study three exemplars of categories as either words or pictures. In the test phase, participants were again shown pictures or words and were asked to determine whether the item was in the same category as something they had studied earlier or whether it was from a new category. We found that all participants demonstrated a robust picture superiority effect, better performance for pictures than for words. These results suggest that the gist-based conceptual processing of pictures is preserved in patients with MCI. While in healthy older adults preserved recollection for pictures could lead to the picture superiority effect, in patients with MCI it is most likely that the picture superiority effect is a result of spared conceptually based familiarity for pictures, perhaps combined with their intact ability to extract and use gist information.

  11. Gist-based memory for prices and "better buys" in younger and older adults.

    Science.gov (United States)

    Flores, Cynthia C; Hargis, Mary B; McGillivray, Shannon; Friedman, Michael C; Castel, Alan D

    2017-04-01

    Ageing typically leads to various memory deficits which results in older adults' tendency to remember more general information and rely on gist memory. The current study examined if younger and older adults could remember which of two comparable grocery items (e.g., two similar but different jams) was paired with a lower price (the "better buy"). Participants studied lists of grocery items and their prices, in which the two items in each category were presented consecutively (Experiment 1), or separated by intervening items (Experiment 2). At test, participants were asked to identify the "better buy" and recall the price of both items. There were negligible age-related differences for the "better buy" in Experiment 1, but age-related differences were present in Experiment 2 when there were greater memory demands involved in comparing the two items. Together, these findings suggest that when price information of two items can be evaluated and compared within a short period of time, older adults can form stable gist-based memory for prices, but that this is impaired with longer delays. We relate the findings to age-related changes in the use of gist and verbatim memory when remembering prices, as well as the associative deficit account of cognitive ageing.

  12. Efeito da restrição alimentar qualitativa precoce sobre o desempenho, as características do trato gastrintestinal e a carcaça de frangos de corte Effects of early-life feed qualitative restriction on performance, characteristics of gastrintestinal tract and carcass of broilers

    Directory of Open Access Journals (Sweden)

    Flavio Alves Longo

    1999-01-01

    Full Text Available O objetivo deste trabalho foi avaliar os efeitos da restrição alimentar qualitativa precoce sobre o desempenho, as características do trato gastrintestinal e a carcaça de frangos de corte. Um total de 975 pintos de corte de um dia da linhagem "Ross", 15 parcelas com 30 machos cada e 15 parcelas com 35 fêmeas, foi distribuído em delineamento experimental inteiramente casualizado, em esquema fatorial 5 x 2 (forma de restrição x sexo, com três repetições por tratamento. As formas de restrição estudadas foram: 1 - testemunha, sem diluição; 2 -diluição com 15% de calcário; 3 - diluição com 30% de calcário; 4 - diluição com 15% de casca de arroz; e 5 - diluição com 30% de casca de arroz. Os frangos foram alimentados ad libitum com ração padrão, no período de 1 a 7 dias e de 15 a 45 dias de idade. A restrição alimentar por diluição das rações, conforme cada tratamento, foi aplicada do 8º ao 14º dia de idade. Para o período de restrição alimentar, foram formuladas rações com níveis normais de minerais e vitaminas, reduzindo-se os outros nutrientes, conforme a diluição. Os frangos submetidos à restrição alimentar qualitativa precoce, pela diluição com 15% de calcário e, 15 ou 30% de casca de arroz, apresentaram ganho compensatório, com bom desempenho final. Entretanto, a restrição com 30% de calcário foi muito severa, prejudicando o desempenho. Houve alteração nas características do trato gastrintestinal com a restrição alimentar, porém houve recuperação até o momento do abate. Os frangos submetidos à restrição alimentar qualitativa precoce apresentaram menor deposição de gordura e maior deposição de proteína na carcaça em comparação ao controle.The objective of this work was to evaluate the effects of the early-life qualitative feed restriction on the performance, gastrintestinal tract characteristics and carcass of broilers. A total of 975 one-d-old "Ross" broiler chicks, 15

  13. Postlearning stress differentially affects memory for emotional gist and detail in naturally cycling women and women on hormonal contraceptives.

    Science.gov (United States)

    Nielsen, Shawn E; Ahmed, Imran; Cahill, Larry

    2014-08-01

    Sex differences in emotional memory have received increasing interest over the past decade. However, to date, no work has explored how a postlearning stressor might modulate the influence of sex hormone status on memory for gist and peripheral detail in an emotional versus neutral context. Here, we tested 3 predictions. First, compared with naturally cycling (NC) women in the luteal phase, women on hormonal contraception (HC) would have significantly blunted hypothalamic-pituitary-adrenal reactivity to physical stress. Second, postlearning stress would enhance detail and gist memory from an emotional story in NC women, and finally, postlearning stress would not affect emotional memory for details or gist in HC women. Healthy NC and HC women viewed a brief, narrated story containing neutral or emotionally arousing elements. Immediately after, cold pressor stress (CPS) or a control procedure was administered. One week later, participants received a surprise free recall test for story elements. NC women exhibited significantly greater cortisol increases to CPS compared with HC women. NC women who viewed the emotional story and were administered CPS recalled the most peripheral details overall and more gist from the emotional compared with the neutral story. In HC women, however, the postlearning cortisol release did not affect memory for gist or peripheral details from the emotional or neutral story in any way. Additionally, NC and HC women performed similarly on measures of attention and arousal. These findings suggest that in women, postlearning stress differentially affects memory for emotional information depending on their hormonal contraceptive status.

  14. Gastrintestinal helminths of capybara (Hydrochoerus hydrochaeris, Linnaeus, 1766 in Cattle Breeding Farm in the area of the Ecological Reserve of Taim, Rio Grande

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    Afonso Lodovico Sinkoc

    2009-04-01

    Full Text Available The aim of this study was we observe the prevalence, intensity and mean intensity of theinfection by gastrintestinal helminths in capybaras. The helminths collected resulted in the following relationship with their respective prevalence and mean intensities of infection: Strongyloides sp. - 62.55% and 168.67; Protozoophaga obesa - 95.83% and 2698.26; Vianella hydrochoeri - 70.83% and 83.82; Hydrochoerisnema anomalobursata - 58.33% and 57.86; Capillaria hydrochoeri - 83.33% and 35.25; Trichuris spp. - 50.00% and 36.58; Hippocrepis hippocrepis - 62.50% and 22.40; Taxorchis schistocotyle - 12.50% and 2.33; Hydrochoeristrema cabrali - 45.83% and 10.73; Monoecocestus hydrochoeri - 50,00% and 28.25 and Monoecocestus jacobi - 41.67% and 5.40. The helminths M. hydrochoeri, Strongyloides sp., Trichuris spp., H. hippocrepis and H. cabrali showed a statistical differences between ages in the mean intensity of parasitism, and the first two presented higher values for the young animals and the last three for the adults.Com o objetivo de observar a prevalência, intensidade e intensidade média de infecção de helmintos gastrintestinais de capivaras foram estudados 24 animais na Granja Santa Maria, região do Banhado do Taim, Município de Rio Grande, RS. As espécies de helmintos coletadas resultaram na seguinte relação, com suas respectivas prevalências e intensidades médias de infecção: Strongyloides sp. - 62,5% e 168,67; Protozoophaga obesa - 95,83% e 2698,26; Vianella hydrochoeri - 70,83% e 83,82; Hydrochoerisnema anomalobursata - 58,33% e 57,86; Capillaria hydrochoeri - 83,33% e 35,25; Trichuris spp. - 50,00% e 36,58; Hippocrepis hippocrepis - 62,50 e 22,40; Taxorchis schistocotyle - 12,50% e 2,33; Hydrochoeristrema cabrali - 45,83% e 10,73; Monoecocestus hydrochoeri - 50,00% e 28,25 e Monoecocestus jacobi - 41,67% e 5,40. Os helmintos M. hydrochoeri, Strongyloides sp., Trichuris spp., H. hippocrepis e H. cabrali diferiram estatisticamente entre

  15. Efeitos do exercício físico sobre o trato gastrintestinal Effects of physical exercise on the gastrointestinal tract

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    Claudio Andre Barbosa de Lira

    2008-02-01

    Full Text Available O impacto do exercício sobre o trato gastrintestinal (TGI, apesar de pouco investigado, é uma área de grande interesse. O exercício aeróbio intenso e de longa duração pode provocar sintomas gastrintestinais. Estes podem ser divididos em sintomas superiores (vômitos, náuseas e pirose retroesternal - azia e inferiores (diarréia, cólica abdominal, perda de apetite, sangramento, aceleração dos movimentos intestinais e vontade de defecar. A etiologia desses sintomas durante o exercício é multifatorial e inclui a redução do fluxo sanguíneo intestinal, a liberação de hormônios gastrintestinais, o estresse mecânico sobre o TGI, a desidratação, os fatores psicológicos, a idade, o sexo, a dieta e o nível de treinamento do indivíduo. Por outro lado, o exercício de baixa intensidade tem efeito protetor sobre o TGI, principalmente com relação à predisposição a certas doenças como o câncer de cólon, a diverticulite, a colelitíase e a constipação. Diversos mecanismos são postulados para explicar os efeitos do exercício sobre o TGI, contribuindo para o desenvolvimento de estratégias terapêuticas no tratamento de indivíduos com sintomas e doenças gastrintestinais.The impact of exercise on the gastrointestinal tract (GI tract, although being little investigated, is a field of high interest. Intense endurance aerobic exercise can lead to gastrointestinal symptoms. These symptoms can be classified into upper symptoms (vomiting, nausea and retrosternal pyrosis - heartburn and lower symptoms (diarrhea, abdominal cramps, loss of appetite, bleeding, accelerated bowel transit time, urge to defecate. These symptoms’ etiology during exercise is multifactorial and includes: reduction of intestinal blood flow, release of gastrointestinal hormones, mechanical stress on the GI tract, dehydration, psychological factors, age, gender, diet, and training status. On the other hand, low intensity exercise has a protective effect on the

  16. Multifocal gastrointestinal stromal tumor (GIST) of the stomach in an 11-year-old girl

    International Nuclear Information System (INIS)

    Park, Jin; Rubinas, Tara C.; Fordham, Lynn A.; Phillips, J.D.

    2006-01-01

    A previously healthy 11-year-old girl presented with an 8-month history of anemia and left upper quadrant abdominal pain. US examination demonstrated a 9-cm cystic mass with a fluid-fluid level in the left upper quadrant with unclear organ of origin. Abdominal MR imaging demonstrated a complex cystic mass, likely arising from the stomach. Additional T2 hyperintense submucosal lesions were identified in the gastric wall. Surgical excision confirmed the diagnosis of multifocal gastric gastrointestinal stromal tumor (GIST). MR imaging was helpful in suggesting a gastric origin of the primary mass and in demonstrating multifocal disease within the stomach. (orig.)

  17. False recall in the Deese–Roediger–McDermott paradigm: The roles of gist and associative strength

    Science.gov (United States)

    Cann, David R.; McRae, Ken; Katz, Albert N.

    2011-01-01

    Theories of false memories, particularly in the Deese–Roediger–McDermott (DRM) paradigm, focus on word association strength and gist. Backward associative strength (BAS) is a strong predictor of false recall in this paradigm. However, other than being defined as a measure of association between studied list words and falsely recalled nonpresented critical words, there is little understanding of this variable. In Experiment 1, we used a knowledge-type taxonomy to classify the semantic relations in DRM stimuli. These knowledge types predicted false-recall probability, as well as BAS itself, with the most important being situation features, synonyms, and taxonomic relations. In three subsequent experiments, we demonstrated that lists composed solely of situation features can elicit a gist and produce false memories, particularly when monitoring processes are made more difficult. Our results identify the semantic factors that underlie BAS and suggest how considering semantic relations leads to a better understanding of gist formation. PMID:21506047

  18. Somatic loss of function mutations in neurofibromin 1 and MYC associated factor X genes identified by exome-wide sequencing in a wild-type GIST case

    International Nuclear Information System (INIS)

    Belinsky, Martin G.; Rink, Lori; Cai, Kathy Q.; Capuzzi, Stephen J.; Hoang, Yen; Chien, Jeremy; Godwin, Andrew K.; Mehren, Margaret von

    2015-01-01

    Approximately 10–15 % of gastrointestinal stromal tumors (GISTs) lack gain of function mutations in the KIT and platelet-derived growth factor receptor alpha (PDGFRA) genes. An alternate mechanism of oncogenesis through loss of function of the succinate-dehydrogenase (SDH) enzyme complex has been identified for a subset of these “wild type” GISTs. Paired tumor and normal DNA from an SDH-intact wild-type GIST case was subjected to whole exome sequencing to identify the pathogenic mechanism(s) in this tumor. Selected findings were further investigated in panels of GIST tumors through Sanger DNA sequencing, quantitative real-time PCR, and immunohistochemical approaches. A hemizygous frameshift mutation (p.His2261Leufs*4), in the neurofibromin 1 (NF1) gene was identified in the patient’s GIST; however, no germline NF1 mutation was found. A somatic frameshift mutation (p.Lys54Argfs*31) in the MYC associated factor X (MAX) gene was also identified. Immunohistochemical analysis for MAX on a large panel of GISTs identified loss of MAX expression in the MAX-mutated GIST and in a subset of mainly KIT-mutated tumors. This study suggests that inactivating NF1 mutations outside the context of neurofibromatosis may be the oncogenic mechanism for a subset of sporadic GIST. In addition, loss of function mutation of the MAX gene was identified for the first time in GIST, and a broader role for MAX in GIST progression was suggested. The online version of this article (doi:10.1186/s12885-015-1872-y) contains supplementary material, which is available to authorized users

  19. Efeito protetor da lactoferrina humana no trato gastrintestinal Efecto protector de la lactoferrina humana en el sistema gastrointestinal Protective effect of human lactoferrin in the gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Valterlinda Alves de O. Queiroz

    2013-03-01

    Full Text Available OBJETIVO: Descrever os mecanismos de ação da lactoferrina humana na proteção de morbidades gastrintestinais. FONTES DE DADOS: Revisão não sistemática da literatura utilizando como estratégia de busca pesquisa bibliográfica em bases de dados, as quais incluíram SciELO, Lilacs e MedLine entre 1990 e 2011. Os descritores utilizados foram: lactoferrina, leite materno/humano, gastrintestinal e imunidade, nos idiomas português e inglês. SÍNTESE DOS DADOS: A lactoferrina é a segunda proteína predominante no leite humano, com concentrações mais elevadas no colostro (5,0 a 6,7mg/mL em relação ao leite maduro (0,2 a 2,6mg/mL. Em contraste, o leite de vaca contém teores inferiores, 0,83mg/mL no colostro e 0,09mg/mL no leite maduro. A lactoferrina desempenha diversas funções fisiológicas na proteção do trato gastrintestinal. A atividade antimicrobiana está relacionada à capacidade de sequestrar ferro dos fluidos biológicos e/ou de desestruturar a membrana de micro-organismos. A lactoferrina possui também a capacidade de estimular a proliferação celular. A ação anti-inflamatória desempenhada pela lactoferrina está associada à capacidade de penetrar no núcleo do leucócito e bloquear a transcrição do fator nuclear Kappa B. Diante da importância da lactoferrina na prevenção de doenças infecciosas em crianças aleitadas ao peito, a indústria vem, por meio da engenharia genética, desenvolvendo tecnologias para expressar esta proteína recombinante humana em plantas e animais, na tentativa de adequar a composição das fórmulas infantis àquela do leite humano. CONCLUSÕES: A lactoferrina humana é um peptídeo com potencial para prevenir morbidades, especialmente às gastrintestinais. Evidências científicas dos efeitos protetores da lactoferrina humana fortalecem ainda mais a recomendação para prática do aleitamento materno.OBJETIVO: Describir los mecanismos de acción de la lactoferrina humana en la protecci

  20. Caracterização de colágenos tipos I e III no estroma do carcinoma de células escamosas cutâneo em cães

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    S.A.O. Bedoya

    2016-02-01

    Full Text Available O carcinoma de células escamosas (CCE é uma neoplasia epitelial maligna que acomete cães e diversas outras espécies, incluindo a humana. O CCE afeta vários sítios anatômicos e pode desenvolver metástase. O objetivo deste estudo foi a caracterização das fibras de colágenos tipos I e III no estroma do CCE cutâneo de cães. Para este trabalho, utilizaram-se 44 amostras de pele incluídas em parafina e que tiveram prévio diagnóstico de CCE. As amostras foram processadas histologicamente e coradas com hematoxilina/eosina para confirmação do diagnóstico e classificação do grau de diferenciação tumoral e com a coloração histoquímica de picrosirius para observação dos colágenos tipos I e III. O colágeno tipo III mostrou maior expressão nos CCEs cutâneos bem diferenciados. O papel do colágeno do tipo III nas neoplasias não está bem esclarecido, e outros fatores além do grau de diferenciação celular podem estar envolvidos em sua expressão e determinar sua importância na biologia tumoral.

  1. Amnesiacs might get the gist: reduced false recognition in amnesia may be the result of impaired item-specific memory.

    Science.gov (United States)

    Nissan, Jack; Abrahams, Sharon; Sala, Sergio Della

    2013-01-01

    It is a common finding in tests of false recognition that amnesic patients recognize fewer related lures than healthy controls, and this has led to assumptions that gist memory is damaged in these patients (Schacter, Verfaellie, & Anes, 1997, Neuropsychology, 11; Schacter, Verfaellie, Anes, & Racine, 1998, Journal of Cognitive Neuroscience, 10; Schacter, Verfaellie, & Pradere, 1996, Journal of Memory and Language, 35). However, clinical observations find that amnesic patients typically hold meaningful conversations and make relevant remarks, and there is some experimental evidence highlighting preserved immediate recall of prose (Baddeley & Wilson, 2002, Neuropsychologia, 40; Gooding, Isaac, & Mayes, 2005, Neuropsychologia, 43; Rosenbaum, Gilboa, Levine, Winocur, & Moscovitch, 2009, Neuropsychologia, 47), which suggests that amnesiacs can get the gist. The present experiment used false recognition paradigms to assess whether the reduced rate of false recognition found in amnesic patients may be a consequence of their impaired item-specific memory. It examined the effect of increasing the item-specific memory of amnesic patient DA by bringing her to criterion on relevant study-lists and compared her performance on a false recognition paradigm with a group of 32 healthy young adults. Results indicated that when DA's item-specific memory was increased she was more able to gist and her performance was no different to the healthy young adults. Previous assumptions that gist memory is necessarily damaged in amnesia might therefore be revisited, since the reduced rate of false recognition could be caused by impaired item-specific memory. The experiment also highlights a positive relationship between item-specific and gist memory which has not previously been accounted for in false-recognition experiments.

  2. Gastrointestinal stromal tumors (GIST) assessment using {sup 18}F-fluordeoxyglucose

    Energy Technology Data Exchange (ETDEWEB)

    Massardo, L T; Gonzalez, P; Jaimovich, R [Nuclear Medicine Section, Medicine Department University of Chile Clinical Hospital (Chile); Jofrea, M J; Canessa, J; Sierralta, P [Molecular Imaging PET Center, Military Hospital, Santiago (Chile)

    2007-11-15

    Introduction: Stromal gastrointestinal tumors (GIST) are relatively infrequent soft sarcomas, although correspond to the most common mesenchymal tumor in the gastrointestinal tract. Surgery is the main therapy during initial stages. Nearly a third of them could be malignant (higher risk) depending on the localization, size and histological parameters. Chemotherapy and radiotherapy have low therapeutic value. Specific molecular therapy associated to surgery using imatinib-mesylate (GLIVEC ) - a selective transductor signal inhibitor for some tyrosine-kinase receptors -is currently use. It is helpful in non-resecables, recurrent or metastatic tumors. Metabolic fluorine I8-deoxyglucose (FDG) allows to characterize tumor behavior demonstrating good predictive value. Promising results have been obtained using adjuvant and neoadjuvant protocols. There are some multicenter in-course trials including FDG in order to evaluate early response to GLIVEC therapy. Other recently developed molecules such as sunitinib malate (SUTENT) are used in non-responders. Method: We have performed 18 FDG studies to 15 GIST patients referred from different centers in a period of 48 months, corresponding approximately to 1% of all cancers in adults. and to 6% of gastrointestinal tumors. The mean age of the group was 57{+-}10.6 y.o., ranging from 33-72 years, 60% of the patients were male. GIST primary localization corresponded to jejunum or ileum (4), duodenum (3), esophagus, stomach (1) besides, 2 retroperitoneal/extra intestinal cases and 5 disseminated cases with no clear origin site. Eight out of fifteen patients presented known dissemination when FDG was performed. PET-FDG was performed to assess: a) medical therapy control in 9 cases: 7 with GLIVEC, 1 with SUTENT post GLIVEC and 1 post chemotherapy, b) re-staging in 6 and c) staging in the other 3 cases (1 submitted to surgery and l extensive tumor to decide GLIVEC therapy). All but one patients already had surgery performed with a mean

  3. Proto-object categorisation and local gist vision using low-level spatial features.

    Science.gov (United States)

    Martins, Jaime A; Rodrigues, J M F; du Buf, J M H

    2015-09-01

    Object categorisation is a research area with significant challenges, especially in conditions with bad lighting, occlusions, different poses and similar objects. This makes systems that rely on precise information unable to perform efficiently, like a robotic arm that needs to know which objects it can reach. We propose a biologically inspired object detection and categorisation framework that relies on robust low-level object shape. Using only edge conspicuity and disparity features for scene figure-ground segregation and object categorisation, a trained neural network classifier can quickly categorise broad object families and consequently bootstrap a low-level scene gist system. We argue that similar processing is possibly located in the parietal pathway leading to the LIP cortex and, via areas V5/MT and MST, providing useful information to the superior colliculus for eye and head control. Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.

  4. Comparing source-based and gist-based false recognition in aging and Alzheimer's disease.

    Science.gov (United States)

    Pierce, Benton H; Sullivan, Alison L; Schacter, Daniel L; Budson, Andrew E

    2005-07-01

    This study examined 2 factors contributing to false recognition of semantic associates: errors based on confusion of source and errors based on general similarity information or gist. The authors investigated these errors in patients with Alzheimer's disease (AD), age-matched control participants, and younger adults, focusing on each group's ability to use recollection of source information to suppress false recognition. The authors used a paradigm consisting of both deep and shallow incidental encoding tasks, followed by study of a series of categorized lists in which several typical exemplars were omitted. Results showed that healthy older adults were able to use recollection from the deep processing task to some extent but less than that used by younger adults. In contrast, false recognition in AD patients actually increased following the deep processing task, suggesting that they were unable to use recollection to oppose familiarity arising from incidental presentation. (c) 2005 APA, all rights reserved.

  5. Cognitive Gains from Gist Reasoning Training in Adolescents with Chronic-Stage Traumatic Brain Injury

    Directory of Open Access Journals (Sweden)

    Lori G. Cook

    2014-06-01

    Full Text Available Adolescents with traumatic brain injury (TBI typically demonstrate good recovery of previously acquired skills. However, higher-order and later emergent cognitive functions are often impaired and linked to poor outcomes in academic and social/behavioral domains. Few control trials exist that test cognitive treatment effectiveness at chronic recovery stages. The current pilot study compared the effects of two forms of cognitive training, gist reasoning (top-down versus rote memory learning (bottom-up, on ability to abstract meanings, recall facts, and utilize core executive functions (i.e., working memory, inhibition in 20 adolescents (ages 12-20 who were six months or longer post-TBI. Participants completed eight 45-minute sessions over one month. After training, the gist reasoning group (n = 10 exhibited significant improvement in ability to abstract meanings and increased fact recall. This group also showed significant generalizations to untrained executive functions of working memory and inhibition. The memory training group (n = 10 failed to show significant gains in ability to abstract meaning or on other untrained specialized executive functions, although improved fact recall approached significance. These preliminary results suggest that relatively short-term training (6 hours utilizing a top-down reasoning approach is more effective than a bottom-up rote learning approach in achieving gains in higher-order cognitive abilities in adolescents at chronic stages of TBI. These findings need to be replicated in a larger study; nonetheless, the preliminary data suggest that traditional cognitive intervention schedules need to extend to later-stage training opportunities. Chronic-stage, higher-order cognitive trainings may serve to elevate levels of cognitive performance in adolescents with TBI.

  6. What's the FOX Got to Do with the KITten? Regulating the Lineage-Specific Transcriptional Landscape in GIST.

    Science.gov (United States)

    Lee, Donna M; Duensing, Anette

    2018-02-01

    Transcriptional regulation of the KIT receptor tyrosine kinase, a master regulator in gastrointestinal stromal tumors (GIST) and their precursors, the interstitial cells of Cajal (ICC), is part of a positive feedback loop involving the transcription factor ETV1. A new study now shows that the forkhead box (FOX) family transcription factor FOXF1 not only is an upstream regulator of ETV1 and hence ICC/GIST lineage-specific gene transcription, but also functions as lineage-specific pioneer factor with an active role in chromatin rearrangement to facilitate ETV1 binding and transcriptional activity. Cancer Discov; 8(2); 146-9. ©2018 AACR See related article by Ran et al., p. 234 . ©2018 American Association for Cancer Research.

  7. Controle de nematóides parasitos gastrintestinais por Arthrobotrys musiformis em ovinos naturalmente infestados mantidos em pastagens Control of gastrintestinal parasitic nematodes by Arthrobotrys musiformis in naturally infested sheep maintained on pastures

    Directory of Open Access Journals (Sweden)

    Érika Barbosa Neves Graminha

    2005-09-01

    Full Text Available Este trabalho objetivou avaliar, in vitro e in vivo, o fungo predador Arthrobotrys musiformis, administrado via oral na forma de conídios microencapsulados em alginato ou in natura em meio líquido, após passagem pelo trato gastrintestinal de ovinos. No teste in vitro, avaliou-se a manutenção da atividade predatória, e no teste in vivo, a capacidade de controlar nematóides parasitos de ovinos naturalmente infectados, mantidos em pastagens. O resultado do teste in vitro confirmou a viabilidade de A. musiformis (95,5%, mesmo após a passagem pelo trato gastrintestinal. Na avaliação in vivo, não houve diferença estatística entre o número de ovos por grama de fezes dos grupos tratados e controle, provavelmente em razão da baixa lotação dos piquetes, da quantidade e periodicidade insuficientes de oferecimento de conídios aos ovinos, o que teria proporcionado dispersão e migração das larvas na pastagem. Contudo, os helmintos recuperados na necropsia dos animais traçadores mostraram que A. musiformis reduziu em 50,9% e 57,6% o número de Trichostrongylus colubriformis dos grupos tratados com conídios microencapsulados e in natura, respectivamente, e em 95% o número de L4 de Haemonchus do grupo tratado com conídios in natura. Embora os resultados não sejam conclusivos, A. musiformis mostrou-se promissor agente no biocontrole de nematóides parasitos gastrintestinais.The objective of the present study was to assess in vitro and in vivo the predatory fungus Arthrobotrys musiformis administered orally, in the form of alginate-microencapsulated conidia, or in natura in liquid medium after passage through the gastrointestinal tract of sheep. Maintenance of the predatory activity of the fungus was evaluated in the in vitro test, and its ability to control parasitic nematodes in naturally infested sheep maintained on pastures was analyzed in the in vivo test. The result of the in vitro test confirmed the viability of A. musiformis (95

  8. Get the gist? The effects of processing depth on false recognition in short-term and long-term memory.

    Science.gov (United States)

    Flegal, Kristin E; Reuter-Lorenz, Patricia A

    2014-07-01

    Gist-based processing has been proposed to account for robust false memories in the converging-associates task. The deep-encoding processes known to enhance verbatim memory also strengthen gist memory and increase distortions of long-term memory (LTM). Recent research has demonstrated that compelling false memory illusions are relatively delay-invariant, also occurring under canonical short-term memory (STM) conditions. To investigate the contributions of gist to false memory at short and long delays, processing depth was manipulated as participants encoded lists of four semantically related words and were probed immediately, following a filled 3- to 4-s retention interval, or approximately 20 min later, in a surprise recognition test. In two experiments, the encoding manipulation dissociated STM and LTM on the frequency, but not the phenomenology, of false memory. Deep encoding at STM increases false recognition rates at LTM, but confidence ratings and remember/know judgments are similar across delays and do not differ as a function of processing depth. These results suggest that some shared and some unique processes underlie false memory illusions at short and long delays.

  9. Enteroscopic Tattooing for Better Intraoperative Localization of a Bleeding Jejunal GIST Facilitates Minimally Invasive Laparoscopically-assisted Surgery.

    Science.gov (United States)

    Iacob, Razvan; Dimitriu, Anca; Stanciulea, Oana; Herlea, Vlad; Popescu, Irinel; Gheorghe, Cristian

    2016-03-01

    We present the case of a 63-year-old man that was admitted for melena and severe anemia. Upper GI endoscopy and colonoscopy failed to identify the lesion responsible for bleeding, and enteroCT scan was also non-contributive to the diagnosis. Capsule endoscopy indicated possible jejunal bleeding but could not indicate the source of bleeding, recommending anterograde enteroscopy. Single balloon enteroscopy identified a 2 cm submucosal tumour in the distal part of the jejunum, with a macroscopic appearance suggesting a gastrointestinal stromal tumour (GIST). The tumor location was marked using SPOT tattoo and subsequently easily identified by the surgeon and resected via minimally invasive laparoscopic-assisted approach. Histological and immunohistochemical analysis indicated a low risk GIST. The unusual small size of the GIST as a modality of presentation, with digestive bleeding and anemia and the ability to use VCE/enteroscopy to identify and mark the lesion prior to minimally invasive surgery, represent the particularities of the presented case.

  10. UPPER GASTRO-INTESTINAL BLEEDING IN THE YOUNG - GASTRIC GIST TUMOR OR PEPTIC ULCER DISEASE?

    Directory of Open Access Journals (Sweden)

    Ayodele Atolagbe

    2015-09-01

    Full Text Available GIST tumors is very unusual in the young and middle aged and a high index of suspicion is needed for the diagnosis in young patients who present with upper gastrointestinal bleeding. Appropriate imaging such as a Computed tomographic scan (CT scan may identify this tumor which may easily be misdiagnosed as a bleeding Peptic Ulcer Disease in the young. We present a case of a healthy 38 year old man with no alcohol use who presented with epigastric pain and melena and subsequent torrential bleeding uncontrolled during endoscopy necessitating an emergency exploratory laparotomy by the general surgery team. The bleeding intraluminal component of the tumor with gross splenic and pancreatic involvement was identified and surgical management consisted of a wedge resection of the greater curvature of the stomach incorporating the tumor and the spleen with successful dissection of the tumor off the tail of the pancreas. Histology was positive for C-KIT and DOG-1 markers. Postoperative course was uneventful and he is presently on Imatinib Mesylate.

  11. FacetGist: Collective Extraction of Document Facets in Large Technical Corpora.

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    Siddiqui, Tarique; Ren, Xiang; Parameswaran, Aditya; Han, Jiawei

    2016-10-01

    Given the large volume of technical documents available, it is crucial to automatically organize and categorize these documents to be able to understand and extract value from them. Towards this end, we introduce a new research problem called Facet Extraction. Given a collection of technical documents, the goal of Facet Extraction is to automatically label each document with a set of concepts for the key facets ( e.g. , application, technique, evaluation metrics, and dataset) that people may be interested in. Facet Extraction has numerous applications, including document summarization, literature search, patent search and business intelligence. The major challenge in performing Facet Extraction arises from multiple sources: concept extraction, concept to facet matching, and facet disambiguation. To tackle these challenges, we develop FacetGist, a framework for facet extraction. Facet Extraction involves constructing a graph-based heterogeneous network to capture information available across multiple local sentence-level features, as well as global context features. We then formulate a joint optimization problem, and propose an efficient algorithm for graph-based label propagation to estimate the facet of each concept mention. Experimental results on technical corpora from two domains demonstrate that Facet Extraction can lead to an improvement of over 25% in both precision and recall over competing schemes.

  12. Special Demographic Zone in Poland - in Search for the Gist of the Phenomenon

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    Katarzyna Gerejczyk

    2017-07-01

    Full Text Available Aim/purpose - The objective of this paper is to identify the gist of the Special Demographic Zone phenomenon by analyzing the changes in the demographic structure of the EU population at country and regional level. Design/methodology/approach - We have applied the Boolean keyword and subject term searches of scholarly articles published in EBSCO and EMERALD databases, as well as in Google Scholar, between 2006 and 2016, inclusive. The key words used in the analysis were: Special Demographic Zone and Special Demographic Zones. This systematic literature review enabled us to identify 15 scientific articles connected directly with the topic in question. Findings - We found that there are 3 strategies employed by the local and regional self-governments to tackle the demographic challenges. We present them as a 3A model, representing strategies: to acknowledge, to adapt and to (counter act. We perceive the Special Demographic Zone, defined as a policy tool, as a specific case of an act strategy. Research implications/limitations - The main implication of the research is that there are already tools and mechanism ready to be utilized by the self-governments in order to tackle demographic challenges, which contribute to the local and regional sustainable development. The recommendation for local authorities is to determine which policy direction (as presented in the 3A model should be embarked on in a given territory in order to maximize the sustainable effect of undertaken actions. Originality/value/contribution - The originality of this work lies in the development of a theoretical 3A model of self-government's policy reactions to the encountered demographic challenges and in the conceptualization of a Special Demographic Zone as a special case of an act policy strategy within the broad framework of regional socioeconomic policy. Furthermore, the article draws on up-to-date statistical data.

  13. The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST) after imatinib failure - one institution study

    International Nuclear Information System (INIS)

    Rutkowski, Piotr; Osuch, Czesław; Mierzejewska, Ewa; Wasielewski, Kacper; Woźniak, Agnieszka; Grzesiakowska, Urszula; Nowecki, Zbigniew I; Siedlecki, Janusz A; Limon, Janusz; Bylina, Elżbieta; Klimczak, Anna; Świtaj, Tomasz; Falkowski, Sławomir; Kroc, Jacek; Ługowska, Iwona; Brzeskwiniewicz, Magdalena; Melerowicz, Wojciech

    2012-01-01

    Gastrointestinal stromal tumors (GIST) mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM) or sunitinib (SU). Arterial hypertension (AH) is common adverse event related to SU, reported as predictive factor in renal cell carcinoma. The aim of the study was to analyze the outcomes and factors predicting results of SU therapy in inoperable/metastatic CD117(+) GIST patients after IM failure. We identified 137 consecutive patients with advanced inoperable/metastatic GIST treated in one center with SU (2 nd line treatment). Median follow-up time was 23 months. Additionally, in 39 patients there were analyzed selected constitutive single nucleotide polymorphisms (SNPs) of VEGFA and VEGFR2 genes. One year progression-free survival (PFS; calculated from the start of SU) rate was 42% and median PFS was 43 weeks. The estimated overall survival (OS, calculated both from start of SU or IM) was 74 weeks and 51 months, respectively. One-year PFS was 65% (median 74 weeks) in 55 patients with AH vs. 22% (median 17 weeks) in patients without AH. Patients with primary tumors carrying mutations in KIT exon 9 or wild-type had substantially better 1-year PFS (68% and 57%; median 65.5 and 50.5 weeks, respectively) than patients having tumors with KIT exon 11 or PDGFRA mutations (34% and 15%; median 36.8 and 9 weeks, respectively). We identified two independent factors with significant impact on PFS and OS in univariate and multivariate analysis: primary tumor genotype and presence of AH. The most common adverse events during therapy were: fatigue, AH, hypothyroidism, hand and foot syndrome, mucositis, skin reactions, dyspepsia, and diarrhea. Two deaths were assessed as related to tumor rupture caused by reaction to SU therapy. The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism (OR: 10.0 p = 0.041 and OR: 10.5; p = 0

  14. The outcome and predictive factors of sunitinib therapy in advanced gastrointestinal stromal tumors (GIST after imatinib failure - one institution study

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    Rutkowski Piotr

    2012-03-01

    Full Text Available Abstract Background Gastrointestinal stromal tumors (GIST mutational status is recognized factor related to the results of tyrosine kinase inhibitors therapy such as imatinib (IM or sunitinib (SU. Arterial hypertension (AH is common adverse event related to SU, reported as predictive factor in renal cell carcinoma. The aim of the study was to analyze the outcomes and factors predicting results of SU therapy in inoperable/metastatic CD117(+ GIST patients after IM failure. Methods We identified 137 consecutive patients with advanced inoperable/metastatic GIST treated in one center with SU (2nd line treatment. Median follow-up time was 23 months. Additionally, in 39 patients there were analyzed selected constitutive single nucleotide polymorphisms (SNPs of VEGFA and VEGFR2 genes. Results One year progression-free survival (PFS; calculated from the start of SU rate was 42% and median PFS was 43 weeks. The estimated overall survival (OS, calculated both from start of SU or IM was 74 weeks and 51 months, respectively. One-year PFS was 65% (median 74 weeks in 55 patients with AH vs. 22% (median 17 weeks in patients without AH. Patients with primary tumors carrying mutations in KIT exon 9 or wild-type had substantially better 1-year PFS (68% and 57%; median 65.5 and 50.5 weeks, respectively than patients having tumors with KIT exon 11 or PDGFRA mutations (34% and 15%; median 36.8 and 9 weeks, respectively. We identified two independent factors with significant impact on PFS and OS in univariate and multivariate analysis: primary tumor genotype and presence of AH. The most common adverse events during therapy were: fatigue, AH, hypothyroidism, hand and foot syndrome, mucositis, skin reactions, dyspepsia, and diarrhea. Two deaths were assessed as related to tumor rupture caused by reaction to SU therapy. The presence of C-allele in rs833061 and the T-allele in rs3025039 polymorphism of VEGFA were associated with significantly higher risk of hypothyroidism

  15. Estudo da mcrobiota fúngica gastrintestinal de morcegos (Mammalia, Chiroptera da região noroeste do estado de São Paulo: potencial zoonótico

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    Luciano Nery Tencate

    2012-04-01

    Full Text Available Os morcegos são hospedeiros de uma rica diversidade de microrganismos. Muitos trabalhos apontam uma estreita ligação entre quirópteros e fungos com potencial patogênico, principalmente por habitarem ambientes como cavernas, grutas e ocos de árvores, favoráveis à manutenção e propagação dos fungos. O objetivo do trabalho foi estudar a microbiota fúngica gastrintestinal de morcegos. Das 98 amostras pertencentes a 11 espécies de morcegos procedentes de 15 cidades estudadas, 20% são da espécie Carollia perspicillata, 19% Artibeus lituratus, 17% Molossus rufus, 13% Glossophaga soricina, 9% Nyctinomops macrotis, 8% Molossus molossus, 7% Desmodus rotundus, 2% Lasiurus ega, e 1% Eptesicus furinalis, Myotis nigricans e Tadarida brasiliensis. O gênero Aspergillus sp. foi isolado de 29% das amostras, seguidos por 6% Microsporum sp. e Penicillium sp., 4% Tricophyton sp. e zigomicetos e 2% Fusarium sp. Das espécies de leveduras, 14% foram de Rhodotorula sp., 10% Candida sp. e 2% Cryptococcus sp., 22% dos isolados permaneceram sem identificação. Todos os 82 cultivos de vísceras foram negativos para Histoplasma capsulatum. Houve associação estatística significativa entre os resultados do cultivo microbiológico e as espécies de morcegos (p < 0,05. Concluímos que os morcegos podem atuar como agentes veiculadores de fungos com potencial patogênico, entretanto outros trabalhos devem ser realizados a fim de estabelecer estratégias que permitam identificar os principais fatores correlacionados com o crescimento e a disseminação dos microrganismos na natureza e qual a implicação dos quirópteros no ciclo epidemiológico.

  16. Unsupervised semantic indoor scene classification for robot vision based on context of features using Gist and HSV-SIFT

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    Madokoro, H.; Yamanashi, A.; Sato, K.

    2013-08-01

    This paper presents an unsupervised scene classification method for actualizing semantic recognition of indoor scenes. Background and foreground features are respectively extracted using Gist and color scale-invariant feature transform (SIFT) as feature representations based on context. We used hue, saturation, and value SIFT (HSV-SIFT) because of its simple algorithm with low calculation costs. Our method creates bags of features for voting visual words created from both feature descriptors to a two-dimensional histogram. Moreover, our method generates labels as candidates of categories for time-series images while maintaining stability and plasticity together. Automatic labeling of category maps can be realized using labels created using adaptive resonance theory (ART) as teaching signals for counter propagation networks (CPNs). We evaluated our method for semantic scene classification using KTH's image database for robot localization (KTH-IDOL), which is popularly used for robot localization and navigation. The mean classification accuracies of Gist, gray SIFT, one class support vector machines (OC-SVM), position-invariant robust features (PIRF), and our method are, respectively, 39.7, 58.0, 56.0, 63.6, and 79.4%. The result of our method is 15.8% higher than that of PIRF. Moreover, we applied our method for fine classification using our original mobile robot. We obtained mean classification accuracy of 83.2% for six zones.

  17. Laparoscopic atypical gastrectomy in the treatment of gastric GIST. Short-term and medium-term outcomes

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    Santiago Reimondez

    2017-08-01

    Full Text Available Gastrointestinal stromal tumors are the most common mesenchymal neoplasms of the gastrointestinal tract. Recently, many studies have addressed the laparoscopic management of these tumors. The aim of this study was to evaluate the safety and efficacy of laparoscopic atypical gastrectomy in the resolution of these neoplasms. In the period between January 2009 and December 2015, 24 patients with suspected gastric GIST less than 5 cm in size underwent surgery under this approach. Abscense of peritoneal and liver metastases and immunohistochemistry expression of CD117 antigen were considered as inclusion criteria. We retrospectively analyzed clinical and histopathological characteristics, surgical outcomes, postoperative complications and oncological results. Statistical analysis included 14 patients. The mean age was 60 years (10 women and 4 men and upper gastrointestinal bleeding was the chief complaint for consultation. Conversion to open surgery was necessary in one case and no major complications, readmissions or reoperations were recorded. The mean tumor size was 41 mm with negative resection margin in all samples. The mean hospital stay was 3 days and no tumor recurrences were recorded in 44 months of follow-up. Laparoscopic atypical gastrectomy for gastric GIST is a safe and effective technique with good outcomes in experienced hands

  18. Gastrointestinal Stromal Tumors (GIST) of the Stomach: Retrospective Experience with Surgical Resection at the National Cancer Institute

    International Nuclear Information System (INIS)

    NAGUIB, Sh.F.; ZAGHLOUL, A.S.; El MARAKBY, H.

    2008-01-01

    Gastric Gist's account for more than half of all gastrointestinal stromal tumors and represent less than 5% of all gastric tumors. The peak age for harboring Gist of the stomach is around 60 years and a slight male preponderance is reported. These tumors are identified by expression of CD117 or CD34 antigen. Symptoms at presentation usually include bleeding, ab¬dominal pain or abdominal mass. Endoscopically, they typically appear as a submucosal mass with or without ulceration and on CT scans an extra gastric mass is usually seen. Complete surgical resection provides the only chance for cure, with only l-2 cm free margins needed. However, local recurrence and/or metastases supervene in almost half the patients treated with surgery alone, even when no gross residual is left. Thereby imatinib mesylate was advocated as an adjuvant to surgery, which appears to have improved disease-free and overall survival. Aim of the Work: The aim of this work was to assess clinico-pathological features of gastrointestinal stromal tumors (GIST) of the stomach and to appraise the results of treatment by surgery in patients treated at the National Cancer Institute (NCI) of Cairo between January 2002 and December 2007. Patients and Methods: Nineteen patients with histologically and immuno-histochemically proven GIST of the stomach were treated by surgery at the NCI during the 6-year study period. Preoperative assessment included detailed history, clinical examination, full laboratory tests, endoscopy, abdominal ultrasound and CT. General medical assessment included chest X-ray, ECG and echocardiography. Results: The patients' age ranged from 26 to 77 years with a median of 51 years. Obvious male/female preponderance was noticed (68.4% to 31.6%). Tumors were located at the upper 1/3 in 42.1%, at the middle 1/3 in 31.6% and at the lower 1/3 in 26.3%. The most common clinical presentation was related to bleeding (hematemesis, melena or anaemia) and was seen in 63.2%. No tumors were

  19. Follow-up of hepatic and peritoneal metastases of gastrointestinal tumors (GIST) under Imatinib therapy requires different criteria of radiological evaluation (size is not everything!!!)

    International Nuclear Information System (INIS)

    Mabille, Mylene; Vanel, Daniel; Albiter, Marcela; Le Cesne, Axel; Bonvalot, Sylvie; Le Pechoux, Cecile; Terrier, Philippe; Shapeero, Lorraine G.; Dromain, Clarisse

    2009-01-01

    Purpose: To define computed tomography (CT) criteria for evaluating the response of patients with gastrointestinal stromal tumors (GIST) who are receiving Imatinib (tyrosine-kinase inhibitor therapy). Materials and methods: This prospective CT study evaluated 107 consecutive patients with advanced metastatic GIST treated with Imatinib. Results: Seventy patients had total or partial cystic-like transformation of hepatic and/or peritoneal metastases. These pseudocysts remained unchanged in size or stable in size on successive CT examinations (stable disease according to RECIST criteria). Forty-six patients developed metastases, 17 patients showed increasing parietal thickness and 29 patients with peripheral enhancing nodules. These CT changes represented local recurrence consistent with GIST resistance to Imatinib treatment. WHO or RECIST criteria did not provide a reliable evaluation of disease evolution or recurrence. Development of new enhancement of lesions (parietal thickness or nodule) was the only reliable criterion. Conclusion: The development of peripheral thickening or enhancing nodules within cystic-like metastatic lesions, even without any change in size, represented progressive GIST under Imatinib, growing in a short time and should alert the clinician for the possible need for a change in therapy

  20. 18FDG-PET at 1-Month Intervals Is a Better Predictive Marker for GISTs That Are Difficult to Be Diagnosed Histopathologically: A Case Report

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    Kazunori Otsuka

    2011-01-01

    Full Text Available Imatinib mesylate is a tyrosine kinase inhibitor of c-KIT and PDGFRA. Imatinib mesylate is an effective drug that can be used as a first-choice agent for treatment of GISTs. Prior to treatment, molecular diagnosis of c-KIT or PDGFRA is necessary; however, in some types of GISTs, it is impossible to obtain a sufficient amount of specimen for diagnosis. An inoperable or marginally resectable GIST in a 79-year-old female was difficult to be diagnosed at a molecular pathological level, and hence, exploratory treatment was initiated using imatinib combined with 18FDG-PET evaluation at 1-month intervals. PET imaging indicated a positive response, and so we continued imatinib treatment in an NAC setting for 4 months. As a result, curative resection of the entire tumor was successfully performed with organ preservation and minimally invasive surgery. 18FDG-PET evaluation at 1-month intervals is beneficial for GISTs that are difficult to be diagnosed histopathologically.

  1. [New orientations in the management of advanced, metastatic gastrointestinal stromal tumors (GIST): combination of surgery and systemic therapy with imatinib in a case of primary gastric location].

    Science.gov (United States)

    Catani, Marco; De Milito, Ritanna; Simi, Mario

    2005-01-01

    Gastrointestinal stromal tumours (GIST) are rare neoplasms originating from connective tissue in the digestive tract with an incidence of less than 1% and account for most non-epithelial primitive digestive tumours. Metastasis diagnosed at the time of disease discovery confirms GIST malignancy. Kit protein, a trans-membrane tyrosine kinase receptor of staminal cells, is characteristically expressed by GIST. Most GIST have a mutation in the kit proto-oncogene. Resistance to conventional chemotherapy is commonly shown by malignant GIST. Most patients with advanced malignant GIST achieve clinical benefit with imatinib mesilate, an orally administered selective inhibitor of the tyrosine kinase receptor. We treated a 43-year-old male patient suffering from a gastric GIST diagnosed during a surgical emergency operation for peritonitis caused by gastric perforation. At the time of the first operation the patient had lost 10 kg body weight over the previous months and was seriously cachectic. During the emergency operation the perforation was sutured. The biopsy results showed the presence of CD1 17 (c-kit) and CD34 markers. A total body CT scan documented the substantial size of the gastric wall lesion, an increased volume of abdominal lymph nodes and compression of the splenic vein with alternative collateral circulation. The liver presented no less than 5 large metastases distributed in both the left and right lobes. There was also a pulmonary metastasis. Because of frequent spontaneous bleeding and starvation the patient was seriously anaemic. Considering the action mechanism of imatinib and the extent of the lesion we decided to perform a total gastrectomy procedure. At the time of the operation the stomach seemed to have a modified volume and shape: it appeared to be divided into two sacs, the larger and deeper of which was the original gastric cavity, while the superficial, smaller one seemed to be a protrusion of the organ. The stomach was indistinguishable from

  2. Post-learning stress differentially affects memory for emotional gist and detail in naturally cycling women and women on hormonal contraceptives

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    Nielsen, Shawn E.; Ahmed, Imran; Cahill, Larry

    2014-01-01

    Sex differences in emotional memory have received increasing interest over the past decade. However, to date, no work has explored how a post-learning stressor might modulate the influence of sex hormone status on memory for gist and peripheral detail in an emotional versus neutral context. Here, we tested three predictions. First, compared to naturally cycling women (NC women) in the luteal phase, women on hormonal contraception (HC women) would have significantly blunted HPA reactivity to physical stress. Second, post-learning stress would enhance detail and gist memory from an emotional story in NC women, and finally, post-learning stress would not affect emotional memory for details or gist in HC women. Healthy NC and HC women viewed a brief, narrated story containing neutral or emotionally arousing elements. Immediately after, Cold Pressor Stress (CPS) or a control procedure was administered. One week later, participants received a surprise free recall test for story elements. NC women exhibited significantly greater cortisol increases to CPS compared to HC women. NC women who viewed the emotional story and were administered CPS recalled the most peripheral details overall and more gist from the emotional compared to the neutral story. In HC women, however, the post-learning cortisol release did not affect memory for gist or peripheral details from the emotional or neutral story in any way. Additionally, NC and HC women performed similarly on measures of attention and arousal. These findings suggest that in women, post-learning stress differentially affects memory for emotional information depending on their hormonal contraceptive status. PMID:24841741

  3. All-trans retinoic acid inhibits KIT activity and induces apoptosis in gastrointestinal stromal tumor GIST-T1 cell line by affecting on the expression of survivin and Bax protein

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    Taguchi Takahiro

    2010-12-01

    Full Text Available Abstract Background Imatinib, a selective tyrosine kinase inhibitor, has been used as a standard first-line therapy for irresectable and metastasized gastrointestinal stromal tumor (GIST patients. Unfortunately, most patients responding to imatinib will eventually exhibit imatinib-resistance, the cause of which is not fully understood. The serious clinical problem of imatinib-resistance demands alternative therapeutic strategy. This study was conducted to investigate the effect of all-trans retinoic acid (ATRA on GIST cell lines. Methods Cell proliferation was determined by trypan blue dye exclusion test. Western blot analysis was performed to test the expression of activated KIT, its downstream proteins, and apoptosis associated proteins. The cytotoxic interactions of imatinib with ATRA were evaluated using the isobologram of Steel and Peckham. Results and conclusion In this work, for the first time we have demonstrated that ATRA affected on cell proliferation of GIST-T1 and GIST-882 cell line through inhibition of cell growth in a dose dependent manner and induced apoptosis. High dose of ATRA induced morphologic change in GIST-T1 cells, rounded-up cells, and activated the caspase-3 protein. In further examination, we found that the ATRA-induced apoptosis in GIST-T1 cells was accompanied by the down-regulated expression of survivin and up-regulated expression of Bax protein. Moreover, ATRA suppressed the activity of KIT protein in GIST-T1 cells and its downstream signal, AKT activity, but not MAPK activity. We also have demonstrated that combination of ATRA with imatinib showed additive effect by isobologram, suggesting that the combination of ATRA and imatinib may be a novel potential therapeutic option for GIST treatment. Furthermore, the scracht assay result suggested that ATRA was a potential reagent to prevent the invasion or metastasis of GIST cells.

  4. Effects of varying presentation time on long-term recognition memory for scenes: Verbatim and gist representations.

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    Ahmad, Fahad N; Moscovitch, Morris; Hockley, William E

    2017-04-01

    Konkle, Brady, Alvarez and Oliva (Psychological Science, 21, 1551-1556, 2010) showed that participants have an exceptional long-term memory (LTM) for photographs of scenes. We examined to what extent participants' exceptional LTM for scenes is determined by presentation time during encoding. In addition, at retrieval, we varied the nature of the lures in a forced-choice recognition task so that they resembled the target in gist (i.e., global or categorical) information, but were distinct in verbatim information (e.g., an "old" beach scene and a similar "new" beach scene; exemplar condition) or vice versa (e.g., a beach scene and a new scene from a novel category; novel condition). In Experiment 1, half of the list of scenes was presented for 1 s, whereas the other half was presented for 4 s. We found lower performance for shorter study presentation time in the exemplar test condition and similar performance for both study presentation times in the novel test condition. In Experiment 2, participants showed similar performance in an exemplar test for which the lure was of a different category but a category that was used at study. In Experiment 3, when presentation time was lowered to 500 ms, recognition accuracy was reduced in both novel and exemplar test conditions. A less detailed memorial representation of the studied scene containing more gist (i.e., meaning) than verbatim (i.e., surface or perceptual details) information is retrieved from LTM after a short compared to a long study presentation time. We conclude that our findings support fuzzy-trace theory.

  5. Gastrointestinal parasites of sheep, municipality of Lajes, Rio Grande do Norte, Brazil Parasitos do trato gastrintestinal de ovinos, município de Lajes, Rio Grande do Norte, Brasil

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    Maria de Fátima de Souza

    2012-03-01

    Full Text Available This study investigated the gastrointestinal parasitism by helminths and protozoa in sheep (Ovis aries Santa Inês breed, municipality of Lajes, Rio Grande do Norte. Monthly, from April 2005 to August 2007, stool samples were collected from two tracer lambs in the first day of the experiment and performed a necropsy of these animals in 44th day. A total of 64 lambs were sampled, but only 62 lambs were slaughtered. The fecal samples were examined by sedimentation in water. The contents of the abomasum, small intestine and large intestine were examined for the recovery of helminths. The parasitological examination revealed eggs of the following groups of helminths: Strongyloidea, Strongyloides sp., Trichuris sp., and Moniezia sp. Also were found oocysts of Eimeria spp., cysts of Entamoeba ovis and Giardia duodenalis. The helminths identified from examining the contents were: Haemonchus contortus, Cooperia pectinata, Cooperia punctata, Trichostrongylus colubriformis, Moniezia expansa, Oesophagostomum sp. Skrjabinema ovis and Trichuris sp.O presente estudo investigou o parasitismo gastrintestinal por helmintos e protozoários em ovinos (Ovis aries da raça Santa Inês, no município de Lajes, Rio Grande do Norte. Mensalmente, entre abril de 2005 e agosto de 2007, foram coletadas amostras fecais de dois cordeiros traçadores no primeiro dia do experimento e realizada a necropsia desses animais no 44º dia. O total de cordeiros amostrados foi 64, mas apenas 62 foram necropsiados. As amostras fecais foram examinadas pela técnica de sedimentação espontânea em água. Os conteúdos do abomaso, intestino delgado e intestino grosso dos cordeiros necropsiados foram examinados para a recuperação dos helmintos. Os exames parasitológicos evidenciaram ovos dos seguintes grupos de helmintos: Strongyloidea, Strongyloides sp. , Trichuris sp., e Moniezia sp. Também foram encontrados oocistos de Eimeria spp., cistos de Entamoeba ovis e de Giardia duodenalis

  6. Linfócitos CD4, CD8 e células NK no estroma da cérvice uterina de mulheres infectadas pelo papilomavírus humano CD4 and CD8 T lymphocytes and NK cells in the stroma of the uterine cervix of women infected with human papillomavirus

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    Daniella Borges Alves

    2010-08-01

    Full Text Available INTRODUÇÃO: A resposta imune pode ser um elemento chave para a progressão ou remissão da infecção pelo papilomavírus humano (HPV no estroma da cérvice uterina. Este estudo objetivou quantificar no estroma cervical a presença de linfócitos T CD4, CD8 e células NK, por imunohistoquímica, em lesões de alto e baixo grau em pacientes infectadas por HPV MÉTODOS: Utilizou-se 56 amostras de biópsia da estroma cervical, sendo 43 amostras positivas para DNA de HPV de alto risco oncogênico e com diagnóstico histopatológico de neoplasia intraepitelial cervical (NIC de alto e baixo grau, ou negativa para lesão intraepitelial e malignidade (NILM, e 13 amostras de pacientes negativas para DNA de HPV com diagnóstico histopatológico NILM RESULTADOS: Maior quantidade de linfócitos T CD4 foi observada em amostras NIC II/III, carcinoma e NILM (p=0,04 e naquelas cuja carga viral esteve entre 10 e 1,000 RLU/PCB. O predomínio de linfócitos T CD8 ocorreu em maior proporção nas amostras NIC II/III (p=0,02 e em amostras com carga viral entre 100 e 1.000 RLU/PCB. As células NK prevaleceram nas amostras com lesões de baixo grau e com baixa carga viral CONCLUSÕES: Este estudo comprovou que nas fases iniciais da infecção, onde não há ainda alterações celulares de alto grau, não temos a presença de células que possam desencadear a fase efetora da resposta imune.INTRODUCTION: Immune response might be a key element regarding the progression or regression of human papillomavirus (HPV infection in the stroma of the uterine cervix. This study aimed to quantify the presence of CD4 and CD8 T lymphocytes and NK cells in the cervical stroma, by means of immunohistochemistry, in high and low grade lesions in patients infected by HPV METHODS: Fifty-six biopsy samples from the uterine cervix were used. Forty-three samples were positive for oncogenic high-risk HPV DNA and had a histopathological diagnosis of high and low-grade cervical intraepithelial

  7. MDCT of primary, locally recurrent, and metastatic duodenal gastrointestinal stromal tumours (GISTs): A single institution study of 25 patients with review of literature

    International Nuclear Information System (INIS)

    Cheng, J.M.; Tirumani, S.H.; Shinagare, A.B.; Jagannathan, J.P.; Hornick, J.L.; Raut, C.P.; Ramaiya, N.H.

    2014-01-01

    Aim: To describe the multidetector computed tomography (MDCT) features of primary, locally recurrent, and metastatic duodenal gastrointestinal stromal tumours (GISTs). Materials and methods: In this institutional review board-approved, Health Insurance Portability and Accountability Act of 1996 (HIPAA)-compliant, retrospective study, 25 patients [13 men, 12 women; mean age 56 years (34–74 years)] with histopathologically confirmed duodenal GISTs seen at Dana Farber Cancer Institute and Brigham and Women's Hospital from December 1999 to October 2009 were identified. The MDCT of primary tumours in six patients and follow-up imaging in all the 25 patients was reviewed by two radiologists in consensus. Electronic medical records were reviewed to document the clinical characteristics and management. Results: The mean size of the primary tumour was 3.7 cm (range 2.5–5.6 cm). Three of six primary tumours were in the second and third portions of the duodenum, one in the third portion, one in the third and fourth portions, and one in the fourth portion. Three of six of the tumours were exophytic, two were both exophytic and intraluminal, and one was intramural. The tumours were well-circumscribed, round or oval masses, with few lobulations, and were either homogeneously hyper-enhancing or heterogeneously isodense at MDCT. None of the tumours had necrosis, haemorrhage, calcification, or loco regional lymphadenopathy on imaging. Sixteen of 25 (64%) patients developed metastatic disease, the most common sites being liver (14/16; 87.5%) and peritoneum (5/16; 31%). Conclusion: Duodenal GISTs are well-circumscribed, round or oval masses, and occur in the second through fourth portions of the duodenum, without lymphadenopathy or duodenal obstruction. Duodenal GISTS metastasize frequently to the liver and peritoneum

  8. Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings

    OpenAIRE

    Di Grezia, G.; Gatta, G.; Rella, R.; Donatello, D.; Falco, G.; Grassi, R.; Grassi, R.

    2017-01-01

    Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today’s experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical interven...

  9. CD63 and GLUT-1 Overexpression Could Predict a Poor Clinical Outcome in GIST: A Study of 54 Cases with Follow-Up

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    Piotr Lewitowicz

    2016-01-01

    Full Text Available Background and Goals. In light of current knowledge, it seems that alternations underlying GISTs are well explained, although all that is enhanced by various aspects on a daily basis. More recently, attention has been pointed towards exosomes as important particles able to modify healthy and also diseased tissues including cancer. The goal of the present study was an analysis of CD9, CD63, and GLUT-1 as a marker of hypoxia status within 54 cases of GIST and evaluation of their predictive value. Methods. 54 cases of patients suffering from GIST were enrolled into the study, predominantly in the gastric location. All operated cases had no Imatinib and other chemotherapies up to the day of operation. Expression of targeted proteins was performed by immunohistochemistry and, after that, the results with tabulated clinical data were compared by Kaplan-Meier method and multivariate Cox proportional hazard model of statistical analysis. Results. Our results presented a marked dependence of worsening clinical outcome with high expression CD63 (p=0.008 as well as with GLUT-1 (p=0.014. We noted a strict correlation of GLUT-1 expression with CD63 expression (p=0.03, which could confirm the thesis about the contribution of exosomes in intratumoural hypoxia status. The collected material did not confirm CD9 contribution. Conclusions. As presented here, CD63 and GLUT-1 have a prognostic value in GIST cases. The results confirm the other studies in this scope and can be used in future as an additional prognostic factor.

  10. Post-learning stress differentially affects memory for emotional gist and detail in naturally cycling women and women on hormonal contraceptives

    OpenAIRE

    Nielsen, Shawn E.; Ahmed, Imran; Cahill, Larry

    2014-01-01

    Sex differences in emotional memory have received increasing interest over the past decade. However, to date, no work has explored how a post-learning stressor might modulate the influence of sex hormone status on memory for gist and peripheral detail in an emotional versus neutral context. Here, we tested three predictions. First, compared to naturally cycling women (NC women) in the luteal phase, women on hormonal contraception (HC women) would have significantly blunted HPA reactivity to p...

  11. Normal development of fetal hepatic haematopoiesis during the second trimester of gestation is upregulated by fibronectin expression in the stromal cells of the portal triads El desarrollo normal de la hematopoyesis hepática fetal durante el segundo trimestre de embarazo está regulado al alza por la expresión de fibronectina en las células del estroma de las tríadas portales

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    D. Tamiolakis

    2007-10-01

    Full Text Available Objective: in midtrimester fetuses the principal site of hematopoiesis is the liver. In hematopoietic organs, stromal cells such as fibroblasts, epithelial cells, and macrophage-like cells develop networks to maintain hematopoiesis, i.e. hematopoietic stem cell self-renewal, proliferation, and growth, by interaction with hematopoietic progenitor cells. ECM glycoproteins produced by the stromal cells are known to play a critical role in the regulation of cell growth and differentiation. Numerous soluble and membrane-bound factors directly regulating haematopoiesis have been documented, but little is known about fetal hepatic stromal cell activity and stromal extracellular matrix protein-fibronectin, on fetal hepatic haematopoiesis. The binding of late stage erythroid cells to fibronectin has been well characterized and is believed to be critical for the terminal stages of erythroid differentiation. The intention of this article is to determine the role of fibronectin in fetal hepatic hematopoietic proliferation and differentiation in different stages of development. Material and method: we examined and compared the immunohistochemical expression of fibronectin in the hepatic stromal portal fields in the 1st, 2nd, and 3rd trimester of gestation respectively, in relation to the appearance of CD34 progenitor hematopoietic, stromal progenitor and vascular endothelial positive cells. Results: our results demonstrated a quantitative difference in the second trimester of gestation concerning the expression of fibronectin in the connective tissue stroma of the hepatic portal fields over the equivalent expression of the protein in the first (p Objetivo: en el segundo trimestre de la gestación, el principal foco de hematopoyesis del feto es el hígado. En los órganos hematopoyéticos, las células del estroma, como fibroblastos, células epiteliales y células de tipo macrófago, desarrollan redes para mantener la hematopoyesis, es decir, la auto

  12. What’s the Gist? The influence of schemas on the neural correlates underlying true and false memories

    Science.gov (United States)

    Webb, Christina E.; Turney, Indira C.; Dennis, Nancy A.

    2017-01-01

    The current study used a novel scene paradigm to investigate the role of encoding schemas on memory. Specifically, the study examined the influence of a strong encoding schema on retrieval of both schematic and non-schematic information, as well as false memories for information associated with the schema. Additionally, the separate roles of recollection and familiarity in both veridical and false memory retrieval were examined. The study identified several novel results. First, while many common neural regions mediated both schematic and non-schematic retrieval success, schematic recollection exhibited greater activation in visual cortex and hippocampus, regions commonly shown to mediate detailed retrieval. More effortful cognitive control regions in the prefrontal and parietal cortices, on the other hand, supported non-schematic recollection, while lateral temporal cortices supported familiarity-based retrieval of non-schematic items. Second, both true and false recollection, as well as familiarity, were mediated by activity in left middle temporal gyrus, a region associated with semantic processing and retrieval of schematic gist. Moreover, activity in this region was greater for both false recollection and false familiarity, suggesting a greater reliance on lateral temporal cortices for retrieval of illusory memories, irrespective of memory strength. Consistent with previous false memory studies, visual cortex showed increased activity for true compared to false recollection, suggesting that visual cortices are critical for distinguishing between previously viewed targets and related lures at retrieval. Additionally, the absence of common visual activity between true and false retrieval suggests that, unlike previous studies utilizing visual stimuli, when false memories are predicated on schematic gist and not perceptual overlap, there is little reliance on visual processes during false memory retrieval. Finally, the medial temporal lobe exhibited an

  13. Usefulness of [18F]FDG-PET in diagnosis of gastric cancer, duodenal ampullary cancer and gastrointestinal storomal tumor (GIST). Study with multi-center survey by questionnaire

    International Nuclear Information System (INIS)

    Torizuka, Tatsuo; Ito, Kengo; Torizuka, Kanji

    2008-01-01

    [ 18 F]fluorodeoxyglucose positron emission tomography (FDG-PET) diagnosis of the three cancers in the title (gastric cancer (GC), duodenal ampullary cancer (DAC) and gastrointestinal storomal tumor (GIST), respectively) is not approved in the health insurance despite their high morbidity in Japan. Clinical usefulness and economical effectiveness in PET diagnosis of these cancers were studied by questionnaire to facilities, where PET had been conducted for the cancers in the period July, 2005-February, 2006. Major questions concerned the purpose and finding of PET, findings by other imaging and by tumor markers, and judgment of PET effectiveness compared with other imaging (more useful, equally or less, and its reason). Patients with GC were 173 cases (120 males, 53 females; mean age 65.3 y), with DAC, 10 (8, 2; 67.6 y), and with GIST, 15 (10, 5; 59.9 y). Obtained were the judgments in GC diagnosis of more useful in 47.4%, equally in 45.1% and less in 7.5%; in DAC, 20, 70 and 10%; and in GIST, 40, 46.7 and 13.3%, respectively. More useful was found in the primary lesion and useful, in the metastatic and recurrent lesions. FDG-PET could detect the latter lesions which had not been found by other imaging techniques, and such findings were thought to be also meaningful from the aspect of medical economics because of possible avoidance of inappropriate surgery and time reduction of hospitalization. (R.T.)

  14. The roles of scene gist and spatial dependency among objects in the semantic guidance of attention in real-world scenes.

    Science.gov (United States)

    Wu, Chia-Chien; Wang, Hsueh-Cheng; Pomplun, Marc

    2014-12-01

    A previous study (Vision Research 51 (2011) 1192-1205) found evidence for semantic guidance of visual attention during the inspection of real-world scenes, i.e., an influence of semantic relationships among scene objects on overt shifts of attention. In particular, the results revealed an observer bias toward gaze transitions between semantically similar objects. However, this effect is not necessarily indicative of semantic processing of individual objects but may be mediated by knowledge of the scene gist, which does not require object recognition, or by known spatial dependency among objects. To examine the mechanisms underlying semantic guidance, in the present study, participants were asked to view a series of displays with the scene gist excluded and spatial dependency varied. Our results show that spatial dependency among objects seems to be sufficient to induce semantic guidance. Scene gist, on the other hand, does not seem to affect how observers use semantic information to guide attention while viewing natural scenes. Extracting semantic information mainly based on spatial dependency may be an efficient strategy of the visual system that only adds little cognitive load to the viewing task. Copyright © 2014 Elsevier Ltd. All rights reserved.

  15. Radiographic anatomy aspects and gastrointestinal transit time in Podocnemis unifilis troschel, 1848 (Testudines, Podocnemididae. = Aspectos anátomo-radiográficos e tempo de trânsito gastrintestinal em Podocnemis unifilis troschel, 1848 (Testudines, Podocnemididae

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    Fernando Moraes Machado Brito

    2010-10-01

    Full Text Available The present study analyzed the radiographic anatomy and determined thegastrointestinal transit time of Podocnemis unifilis. We used ten animals belonging to LAPAS from the Federal University of Uberlândia, Uberlândia, Minas Gerais State, Brazil. The animals were orally fed with a barium sulphate suspension at 10 mL kg-1 mixed with mineral oil, at a ratio of 70% of barium sulphate for 30% of mineral oil. Afterwards, the animals underwent radiography in a dorsum ventriloquoal position, with the X-ray device adjusted at 72 Kv and 200 mA, in time intervals to follow the permanency of contrast in the organism. Five minutes after the contrast was supplied, the stomach was filled. After sixteen hours the contrast advanced to the smallintestine. In 48 hours, the whole small intestine and part of the colon were fulfilled. On the 9th day the stomach was empty and the contrast advanced to the colon. On the 11th day, the colon was totally fulfilled, and the contrast was close to cloaca. On the 18th day all contrast was eliminated by the animal. Total time for contrast elimination was, in average, 17.6 ± 2.4 days, with the minimum of 12 and maximum of 22 days, with temperature at 27ºC. The digestion of the food was slower in the duodenum, and faster in the colon-rectum, which presents lower indices of repletion.Avaliou-se aspectos anátomo-radiográficos bem como o tempo de trânsito gastrintestinal em Podocnemis unifilis. Foram utilizados 10 animais pertencentes ao Laboratório de Pesquisas em Animais Silvestres(LAPAS da Universidade Federal de Uberlândia, Uberlândia, Minas Gerais, Brasil. Aos animais foi administrada, por via oral, uma suspensão de sulfato de bário 10 mL kg-1 misturada com óleo mineral na proporção de 70% de sulfato de bário para 30% de óleo. Posteriormente, os animais foram radiografados dorso-ventralmente, com o aparelho de raios-X regulado para 72 Kv e 200 mA, em intervalos de tempo pré-estabelecidos. Em média, cinco

  16. Plantas medicinais usadas nos distúrbios do trato gastrintestinal no povoado Colônia Treze, Lagarto, SE, Brasil Medicinal plants used for aliments of the gastro-intestinal tract at Colonia Treze village, Lagarto Municipality, Sergipe State, Brazil

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    Maria Silene da Silva

    2006-12-01

    Full Text Available Os modelos de desenvolvimento sócio-econômicos adotados pela sociedade humana refletem diferentes formas de relacionamento com a natureza, as quais no paradigma vigente têm levado à grande perda de recursos naturais. Na esfera dessa relação, a conservação e preservação da biodiversidade da flora medicinal torna-se fundamental, pela importância que as plantas medicinais assumem como potencial genético para o desenvolvimento de novas drogas, e como acesso primário à saúde para muitas comunidades. Utilizando a abordagem etnofarmacológica na pesquisa de plantas medicinais, este trabalho teve por objetivo estudar as plantas medicinais utilizadas popularmente contra distúrbios do trato gastrintestinal no povoado Colônia Treze em Lagarto, SE, comunidade que tem o uso popular das plantas medicinais inserido em sua cultura. Sua metodologia abrangeu trabalho de campo na comunidade, adotando o método etnográfico qualitativo rápido. A amostra foi composta por líderes da comunidade, usuários de plantas e praticantes da medicina popular. Baseando-se nas indicações populares sobre o uso das plantas medicinais, selecionaram-se oito plantas que foram submetidas aos experimentos farmacológicos. As plantas testadas no Modelo de Trânsito Intestinal não produziram alteração na motilidade. Já as submetidas ao Modelo de Indução de Lesão Gástrica aguda, mostraram-se efetivas na atividade antiulcerogênica. A partir destes resultados propõem-se estratégias de desenvolvimento local para esta comunidade, que aliem a conservação da flora medicinal à melhoria de sua qualidade de vida.Models of socioeconomic development adopted by human societies reflect different ways of relating to Nature, which, given the present paradigm, have evolved towards great natural-resource loss. Within the sphere of this relationship, both the conservation and preservation of medicinal-plant biodiversity are fundamental because of the importance of

  17. TRACG prediction of gravity-driven cooling system response in the SBWR/GIST facility LOCA tests

    International Nuclear Information System (INIS)

    Alamgir, M.; Andersen, J.G.M.; Yang, A.I.; Shiralkar, B.S.

    1990-01-01

    General Electric (BE) Nuclear Energy has initiated work on technology programs in support of the advanced light water reactor (ALWR) plants under contract to the U.S. Department of Energy (DOE). Work has been performed under the advanced boiling water reactor (ABWT) design verification program and the simplified boiling water reactor (SBWR) program. The objective of the SBWR program is to develop the key features of a simplified reactor design. The gravity-driven cooling system (GDCS) is an important feature of the SBWR design. The main objectives of the GDCS test program at GE were to demonstrate the technical feasibility of the GDCS concept by performing a section-scaled integrated systems test of the SBWR design and to provide a data base to qualify the TRACG computer code for use in SBWR accident analysis. This paper describes the qualification of TRACG for GDCS applications. The calculational capability and analytical models of TRACG are tested by performing assessment analysis for five loss-of-coolant-accident (LOCA) tests in the GDCS Integrated Systems Test (GIST) facility. The results of the qualification comparisons are presented and TRACG application ranges are discussed

  18. Rapid gist perception of meaningful real-life scenes: Exploring individual and gender differences in multiple categorization tasks

    Science.gov (United States)

    Vanmarcke, Steven; Wagemans, Johan

    2015-01-01

    In everyday life, we are generally able to dynamically understand and adapt to socially (ir)elevant encounters, and to make appropriate decisions about these. All of this requires an impressive ability to directly filter and obtain the most informative aspects of a complex visual scene. Such rapid gist perception can be assessed in multiple ways. In the ultrafast categorization paradigm developed by Simon Thorpe et al. (1996), participants get a clear categorization task in advance and succeed at detecting the target object of interest (animal) almost perfectly (even with 20 ms exposures). Since this pioneering work, follow-up studies consistently reported population-level reaction time differences on different categorization tasks, indicating a superordinate advantage (animal versus dog) and effects of perceptual similarity (animals versus vehicles) and object category size (natural versus animal versus dog). In this study, we replicated and extended these separate findings by using a systematic collection of different categorization tasks (varying in presentation time, task demands, and stimuli) and focusing on individual differences in terms of e.g., gender and intelligence. In addition to replicating the main findings from the literature, we find subtle, yet consistent gender differences (women faster than men). PMID:26034569

  19. Órgãos internos e trato gastrintestinal de novilhos de gerações avançadas do cruzamento rotativo entre as raças Charolês e Nelore terminados em confinamento Internal organs and gastrointestinal tract of feedlot finished steers of advanced generations of rotational crossbreeding between Charolais and Nellore

    Directory of Open Access Journals (Sweden)

    Luís Fernando Glasenapp de Menezes

    2007-02-01

    Full Text Available Foram avaliados os efeitos de heterose e de grupo genético nos órgãos internos e no trato gastrintestinal de novilhos puros (Charolês - C e Nelore - N e cruzados da segunda (G2 (3/4C 1/4N e 3/4N 1/4C, terceira (G3 (5/8C 3/8N e 5/8N 3/8C e quarta (G4 (11/16C 5/16N e 11/16N 5/16C gerações de cruzamento terminados em confinamento e abatidos com 23 meses de idade. Os animais cruzados da G2, G3 e G4 foram, respectivamente, 14,95; 17,25 e 18,46% superiores aos puros quanto ao peso de corpo vazio (PCVZ. A heterose para o rendimento de carcaça fria em relação ao PCVZ (RCFCVZ foi positiva em todas as gerações. Os mestiços apresentaram menor peso relativo (ao PCVZ de coração, pulmões e rins, de modo que a heterose foi significativa para peso de coração (-18,29% e rins (-14,29% na G3 e para pulmões (-13,45% na G4. Novilhos mestiços apresentaram valores inferiores à média dos puros para todos os componentes do trato gastrintestinal quando o peso destes componentes foi expresso em relação a 100 kg de PCVZ ou de peso vivo ao abate (PVA, com exceção do rúmen na G2. A heterose retida foi positiva e significativa para PCVZ, RCFCVZ e para peso absoluto do fígado. Entretanto, foi negativa para a quantidade de sangue para os pesos de coração, intestino delgado + grosso e trato gastrintestinal quando expressos em relação a 100 kg de PCVZ e de PVA. Entre os animais puros, os novilhos Nelore tiveram maior RCFCVZ (57,09 vs 61,64%. O peso absoluto de rúmen, abomaso, intestino delgado + grosso e o trato gastrintestinal foram maiores nos novilhos Charolês em relação aos Nelore, o que também foi observado quando estes componentes foram expressos em relação ao PCVZ e PVA, com exceção para o intestino grosso + delgado. Estas diferenças explicam, em parte, o maior rendimento de carcaça dos novilhos Nelore.The objective of this trial was to investigate the effect of heterosis and genetic group on the yield and weight of internal organs

  20. Caracterização biométrica externa, avaliação corpórea e caracterização histológica do trato gastrintestinal de gaviões-carijó (Rupornis magnirostris apreendidos pelo CETAS/IBAMA na Paraíba

    Directory of Open Access Journals (Sweden)

    Millena de Oliveira Firmino

    2013-10-01

    Full Text Available http://dx.doi.org/10.5007/2175-7925.2014v27n1p101   Este estudo teve por objetivo analisar as medidas biométricas externas e do sistema digestório e, também, as condições corpóreas e de plumagem de gaviões-carijó apreendidos pelo CETAS/IBAMA na Paraíba, e descrever a histologia das vísceras do trato gastrintestinal (TGI, tendo como foco fornecer subsídios para novos estudos na área de nutrição animal e classificação taxonômica, bem como para sistemas de manejo e de conservação. Os espécimes foram analisados, tiveram as medidas mensuradas e coletadas amostras biológicas para procedimentos histológicos. Constatou-se que existe relação entre a condição corpórea e a perda de plumagem, demonstrando que a morfologia do TGI é semelhante à da maioria das aves já descritas, incluindo outras espécies de Accipitridae. Os resultados proporcionam subsídios para estudos posteriores envolvendo manejo nutricional, conservacionista, clínico e cirúrgico para a espécie.

  1. The Effectiveness of Model Learning CUPs: Impact on The Higher Order Thinking Skill Students at Madrasah Aliyah Mathla'ul Anwar Gisting Lampung

    Directory of Open Access Journals (Sweden)

    Antomi Saregar

    2016-10-01

    Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran CUPs (Conceptual Understanding Procedures terhadap kemampuan berpikir tingkat tinggi peserta didik kelas X IPA MA Mathla’ul Anwar Gisting. Metode penelitian yang digunakan adalah kuasi eksperimen dengan desain non equivalent control group. Populasi dalam penelitian ini berjumlah 52 peserta didik, dengan sampel X IPA 1 sebagai kelas eksperimen dan X IPA 2 sebagai kelas kontrol. Uji independent sample t-test digunakan untuk mengetahui perbedaan kemampuan berpikir tingkat tinggi peserta didik menggunakan model CUPs dengan model pembelajaran langsung. Hasil analisis menyatakan bahwa terdapat perbedaan rata-rata kemampuan berpikir tingkat tinggi peserta didik antara menggunakan model CUPs dengan model pembelajaran langsung. efektivitas penggunaan model CUPs lebih baik dalam meningkatkan kemampuan berpikir tingkat tinggi peserta didik, dapat diketahui dari nilai effect size yang diperoleh sebesar 0,3 termasuk dalam kategori sedang. Kata kunci: conceptual understanding procedures, HOTS, kemampuan berpikir tingkat tinggi, model CUPs

  2. Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings

    Science.gov (United States)

    Gatta, G.; Rella, R.; Donatello, D.; Falco, G.; Grassi, R.

    2017-01-01

    Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical intervention or clinical follow-up. The clinical presentation of this illness is frequently nonspecific: abdominal pain, distension, nausea, fever, rectal bleeding, vomiting, constipation, or a palpable mass, depending on the disease. A proper differential diagnosis is essential in the assessment of treatment and in this case MDCT exam plays a central rule. We wish that this article will familiarize the radiologist in the diagnosis of this kind of incidental MDCT findings for better orientation of the therapy. PMID:28638830

  3. Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings

    Directory of Open Access Journals (Sweden)

    G. Di Grezia

    2017-01-01

    Full Text Available Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today’s experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical intervention or clinical follow-up. The clinical presentation of this illness is frequently nonspecific: abdominal pain, distension, nausea, fever, rectal bleeding, vomiting, constipation, or a palpable mass, depending on the disease. A proper differential diagnosis is essential in the assessment of treatment and in this case MDCT exam plays a central rule. We wish that this article will familiarize the radiologist in the diagnosis of this kind of incidental MDCT findings for better orientation of the therapy.

  4. Abdominal Hernias, Giant Colon Diverticulum, GIST, Intestinal Pneumatosis, Colon Ischemia, Cold Intussusception, Gallstone Ileus, and Foreign Bodies: Our Experience and Literature Review of Incidental Gastrointestinal MDCT Findings.

    Science.gov (United States)

    Di Grezia, G; Gatta, G; Rella, R; Donatello, D; Falco, G; Grassi, R; Grassi, R

    2017-01-01

    Incidental gastrointestinal findings are commonly detected on MDCT exams performed for various medical indications. This review describes the radiological MDCT spectrum of appearances already present in the past literature and in today's experience of several gastrointestinal acute conditions such as abdominal hernia, giant colon diverticulum, GIST, intestinal pneumatosis, colon ischemia, cold intussusception, gallstone ileus, and foreign bodies which can require medical and surgical intervention or clinical follow-up. The clinical presentation of this illness is frequently nonspecific: abdominal pain, distension, nausea, fever, rectal bleeding, vomiting, constipation, or a palpable mass, depending on the disease. A proper differential diagnosis is essential in the assessment of treatment and in this case MDCT exam plays a central rule. We wish that this article will familiarize the radiologist in the diagnosis of this kind of incidental MDCT findings for better orientation of the therapy.

  5. [A Study on the quotations in the Wu xing da yi (The Gist of Five Phases) cited from Nei jing (Inner Canon)].

    Science.gov (United States)

    Wang, Zheng-Shan; Zhang, Qi-Cheng

    2013-07-01

    In the Wu xing da yi (The Gist of Five Phases), written by Xiao Ji of the Sui Dynasty, there were 9 quotations cited from Huang di nei jing (Inner Canon of Huangdi). By comparison with current version of Huang di nei jing, most of the descriptions are similar, yet still with some differences, such as yin-yang nature of the five zang visceras, the liver being the root of "pi ji", the spleen being the root of "cang lin" etc. Wu xing da yi epitomizes the books about yin-yang and five phases before the Sui Dynasty, while Xiao Ji's quotations from Huang di nei jing interpreted from the views of yin-yang and five phases, are different from the annotations of later ages.

  6. Digestibilidade e tempo de trânsito gastrintestinal de dietas contendo níveis crescentes de fibra bruta para pacu - doi: 10.4025/actascianimsci.v32i2.8625 Digestibility and gastrointestinal transit time of diets with increasing dietary fiber levels to pacu - doi: 10.4025/actascianimsci.v32i2.8625

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    Thiago Matias Torres Nascimento

    2010-07-01

    Full Text Available O objetivo deste trabalho foi avaliar a digestibilidade e o tempo de trânsito gastrintestinal (TTGI de dietas contendo níveis crescentes de fibra bruta (FB para pacus. Para avaliar a digestibilidade foram utilizados 288 pacus, em delineamento inteiramente casualizado, alimentados em aquários e transferidos para coletores do tipo Guelf Modificado, utilizando-se o método de coleta parcial de fezes. As rações foram marcadas com 1% de óxido de crômio para a determinação da digestibilidade das dietas. No ensaio de TTGI, 288 pacus foram distribuídos em 24 aquários em delineamento inteiramente casualizado e alimentados com rações contendo 1% óxido de titânio ou crômio, que apresentam cores diferentes, verde ou branca, respectivamente. Por meio de massagem abdominal foi averiguada periodicamente a cor das fezes, e o TTGI foi estabelecido quando as fezes de todos os peixes apresentaram cor verde. Os coeficientes de digestibilidade aparente das dietas e o TTGI foram reduzidos com aumento do nível de FB nas dietas. Conclui-se que em dietas para pacus pode-se empregar até 9% de FB sem efeito negativo na digestibilidade da energia, proteína, matéria seca e estrato etéreo e sem alterar o TTGI.This work aimed to evaluate the effect of increasing dietary fiber levels on the digestibility and gastrointestinal transit time (GTT for pacu. The digestibility trial used 288 pacu in a completely randomized design, fed in aquaria and transferred to a modified Guelf-type feces collector, using the partial sampling method. The inert marker on the diets was chromic oxide (1% to establish the diet digestibility. In the GTT assay, 288 pacu were distributed in 24 aquaria in a completely randomized design. Fish were fed with two colored diets – green and white – and feces color was determined after abdominal pressure. The white and green diets used 1% of titanium and chromic oxides, respectively. Total GTT was determined when all fish showed green

  7. Diffusion-weighted magnetic resonance imaging in metastatic gastrointestinal stromal tumor (GIST) - A pilot study on the assessment of treatment response in comparison with 18F-FDG PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, Sabine; Koehli, Melanie; Meuli, Reto [Dept. of Radiology, Centre Hospitalier Universitaire Vaudois, Univ. of Lausanne, Lausanne (Switzerland)], e-mail: sabine.schmidt@chuv.ch; Dunet, Vincent; Prior, John O. [Dept. of Nuclear Medicine, Centre Hospitalier Universitaire Vaudois, Uniausanne, Lausanne (Switzerland); Montemurro, Michael [Dept. of Oncology, Centre Hospitalier Universitaire Vaudois (CHUV), Univ. of Lausanne, Lausanne (Switzerland)

    2013-10-15

    Background: Diffusion-weighted magnetic resonance imaging (MRI) is increasingly being used for assessing the treatment success in oncology, but the real clinical value needs to evaluated by comparison with other, already established, metabolic imaging techniques. Purpose: To prospectively evaluate the clinical potential of diffusion-weighted MRI with apparent diffusion coefficient (ADC) mapping for gastrointestinal stromal tumor (GIST) response to targeted therapy compared with 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT). Material and Methods: Eight patients (mean age, 56{+-}11 years) known to have metastatic GIST underwent 18F-FDG PET/CT and MRI (T1Gd, DWI [b = 50,300,600], ADC mapping) simultaneously, before and after change in targeted therapy. MR and PET/CT examinations were first analyzed blindly. Second, PET/CT images were co-registered with T1Gd-MR images for lesion detection. Only 18F-FDG avid lesions were considered. Maximum standardized uptake value (SUV{sub max}) and the corresponding minimum ADC{sub min} were measured for the six largest lesions per patient, if any, on baseline and follow-up examinations. The relationship between changes in SUV{sub max} and ADCmin was analyzed (Spearman's correlation). Results: Twenty-four metastases (12 hepatic, 12 extra-hepatic) were compared on PET/CT and MR images. SUV{sub max} decreased from 7.7{+-}8.1 g/mL to 5.5{+-}5.4 g/mL (P = 0.20), while ADC{sub min} increased from 1.2{+-}0.3 X 10{sup -3}mm{sup 2}/s to 1.5{+-}0.3 X 10{sup -3}mm{sup 2}/s (P = 0.0002). There was a significant association between changes in SUV{sub max} and ADC{sub min} (rho = - 0.62, P = 0.0014), but not between changes in lesions size (P = 0.40). Conclusion: Changes in ADCmin correlated with the response of 18F-FDG avid GIST to targeted therapy. Thus, diffusion-weighted MRI may represent a radiation-free alternative for follow-up treatment for metastatic GIST patients.

  8. Effects of topical 0.2% Cyclosporine A on corneal neovascularization induced by xenologous amniotic membrane implantation into a corneal stroma micropocket of rats Efeitos do uso tópico da Ciclosporina A (CsA 0,2% na neovascularização corneal induzida pelo implante de membrana amniótica xenógena em microbolsa no estroma da córnea de ratos

    Directory of Open Access Journals (Sweden)

    Juliana F. Milani

    2008-08-01

    efeitos tópicos da Ciclosporina a 0,2% (CsA sobre a neovascularização corneana de ratos após implante cirúrgico de membrana amniótica eqüina em microbolsa do estroma corneana. O implante da membrana foi feito bilateralmente em 90 ratos. O tratamento com CsA iniciou-se no mesmo dia da cirurgia, nos olhos direitos dos animais, duas vezes ao dia. Os olhos esquerdos não receberam nenhum tratamento e serviram de controle. A avaliação da neovascularização corneana foi feita por análise de imagem computadorizada e por exame histopatológico aos dias 1, 3, 7, 15, 30 e 60 de pós-cirúrgico. Para a análise de imagem foram utilizados 10 animais por período, e para o exame histopatológico, 5 por período. A análise de imagem demonstrou que a neovascularização iniciou-se no 3° dia pós-cirúrgico, alcançou seu pico no 7° dia e então regrediu rápida e progressivamente até o 60° dia. A análise estatística indicou que a neovascularização no 7º dia nos olhos tratados com CsA foi significantemente mais acentuada do que aquela observada nos olhos não tratados. Entretanto, no 30º dia este fato se reverteu, e a neovascularização observada nos olhos tratados com CsA diminuíra a níveis baixos comparáveis àquela do 3º dia. Já nos olhos não tratados, o grau de neovascularização somente pôde ser comparado àquele nível básico encontrado no 3º dia aos 60 dias de pós-operatório. A análise histopatológica demonstrou que a deposição de colágeno no tecido implantado se completou no 15º dia. Desta maneira, foi possível concluir que (1 a membrana amniótica em estroma corneano de ratos produz intensa neovascularização até o 15º dia de pós-operatório com posterior regressão, (2 a deposição de colágeno do tecido implantado foi completa ao 15º dia de pós-operatório, e que (3 o uso de CsA esteve associado com aumento inicial da neovascularização corneana, seguido de rápida e intensa regressão.

  9. Guidelines for time-to-event end point definitions in sarcomas and gastrointestinal stromal tumors (GIST) trials: results of the DATECAN initiative (Definition for the Assessment of Time-to-event Endpoints in CANcer trials)†.

    Science.gov (United States)

    Bellera, C A; Penel, N; Ouali, M; Bonvalot, S; Casali, P G; Nielsen, O S; Delannes, M; Litière, S; Bonnetain, F; Dabakuyo, T S; Benjamin, R S; Blay, J-Y; Bui, B N; Collin, F; Delaney, T F; Duffaud, F; Filleron, T; Fiore, M; Gelderblom, H; George, S; Grimer, R; Grosclaude, P; Gronchi, A; Haas, R; Hohenberger, P; Issels, R; Italiano, A; Jooste, V; Krarup-Hansen, A; Le Péchoux, C; Mussi, C; Oberlin, O; Patel, S; Piperno-Neumann, S; Raut, C; Ray-Coquard, I; Rutkowski, P; Schuetze, S; Sleijfer, S; Stoeckle, E; Van Glabbeke, M; Woll, P; Gourgou-Bourgade, S; Mathoulin-Pélissier, S

    2015-05-01

    The use of potential surrogate end points for overall survival, such as disease-free survival (DFS) or time-to-treatment failure (TTF) is increasingly common in randomized controlled trials (RCTs) in cancer. However, the definition of time-to-event (TTE) end points is rarely precise and lacks uniformity across trials. End point definition can impact trial results by affecting estimation of treatment effect and statistical power. The DATECAN initiative (Definition for the Assessment of Time-to-event End points in CANcer trials) aims to provide recommendations for definitions of TTE end points. We report guidelines for RCT in sarcomas and gastrointestinal stromal tumors (GIST). We first carried out a literature review to identify TTE end points (primary or secondary) reported in publications of RCT. An international multidisciplinary panel of experts proposed recommendations for the definitions of these end points. Recommendations were developed through a validated consensus method formalizing the degree of agreement among experts. Recommended guidelines for the definition of TTE end points commonly used in RCT for sarcomas and GIST are provided for adjuvant and metastatic settings, including DFS, TTF, time to progression and others. Use of standardized definitions should facilitate comparison of trials' results, and improve the quality of trial design and reporting. These guidelines could be of particular interest to research scientists involved in the design, conduct, reporting or assessment of RCT such as investigators, statisticians, reviewers, editors or regulatory authorities. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  10. Margem de segurança do meloxicam em cães: efeitos deletérios nas células sangüíneas e trato gastrintestinal Margin of safety of meloxicam in dogs: deleterious effects on blood cells and gastrointestinal tract

    Directory of Open Access Journals (Sweden)

    Marilac Maria Arnaldo Alencar

    2003-06-01

    Full Text Available Este trabalho investigou a margem de segurança do inibidor COX-2, meloxicam, em cães, enfocando seus efeitos deletérios nas células sangüíneas e no trato gastrintestinal. Para tanto, após uma avaliação clínico-laboratorial, os cães foram distribuídos nos seguintes grupos: I (placebo; n= 3, II (piroxicam; 1,0mg kg-1; n= 5, III (meloxicam; 0,2mg kg-1; n= 5, IV (meloxicam;1,0mg kg-1; n= 5 e V (meloxicam; 2,0mg kg-1; n= 5. Os fármacos foram usados, por via oral, por 16 dias. No 17º dia, repetiu-se o hemograma completo e, então, procedeu-se a eutanásia seguida pela necrópsia. No grupo I, não houve alterações dignas de nota. No grupo II, todos os cães apresentaram episódios moderados de vômito e diarréia. O perfil celular sangüíneo não foi significativamente modificado. Em dois cães, houve redução no hematócrito e na hemoglobina. Na necropsia, observaram-se focos hemorrágicos e lesões gastriduodenais moderadas. A análise microscópica revelou a presença de gastrite e enterite ulcerativa. No grupo III, quatro cães (80% apresentaram vômito e diarréia, sem alteração no perfil celular sangüíneo. Na análise macroscópica, observaram-se lesões brandas na mucosa gástrica e focos hemorrágicos no duodeno em quatro cães. Na histopatologia, observaram-se lesões sugestivas de discreta gastroenterite. No grupo IV, os cinco cães tiveram vômito e diarréia sanguinolenta. Quatro deles (80% apresentaram anemia (p This study investigated the margin of safety of the COX-2e inhibitor, meloxicam on blood cells and gastrointestinal tract of dogs. After a clinical and laboratorial examination, the dogs were distributed in the following groups: I (placebo; n=3, II (piroxicam: 1.0mg kg-1; n=5, III (meloxicam: 0.2mg kg-1; n=5, IV (meloxican: 1.0mg kg-1; n=5 and V (meloxican: 2.0mg kg-1; n=5. The drugs were given orally for 16 days. On the 17th day the complete hemogram was repeated and the euthanasia and necropsy were then

  11. Emotionally Negative Pictures Enhance Gist Memory

    OpenAIRE

    Bookbinder, S. H.; Brainerd, C. J.

    2016-01-01

    In prior work on how true and false memory are influenced by emotion, valence and arousal have often been conflated. Thus, it is difficult to say which specific effects are due to valence and which are due to arousal. In the present research, we used a picture-memory paradigm that allowed emotional valence to be manipulated with arousal held constant. Negatively-valenced pictures elevated both true and false memory, relative to positive and neutral pictures. Conjoint recognition modeling reve...

  12. Metaheurísticas Multiobjetivo Cardumen de Peces Artificiales (FAFS y Optimización Evolucionaria por Enjambre de Partículas con Topología Estocástica Global Individual (FEPSO GIST. Parte I: Antecedentes y Desarrollos Teóricos

    Directory of Open Access Journals (Sweden)

    Gustavo Alejandro

    2014-06-01

    Full Text Available El presente trabajo describe un modelo para la optimización del grado de desbalance de cargas en una red trifásica de distribución de energía eléctrica (SDEE en baja tensión (BT. Se presenta la integración de dos novedosas metaheurísticas: FEPSO GIST (Fuzzy-MultiObjective Particles Swarm Optimization with Global/Individual Stochastic Topology desarrollada por el autor, y FAFS (Fuzzy- MultiObjective Artificial Fish Shool, cuya extensión multiobjetivo es propuesta por el autor, se valoriza la función de aptitud mediante conjuntos difusos. El problema propuesto ya ha sido resuelto en un trabajo presentado por el autor, mediante la metaheurística FPSO, y su solución constituye una referencia para comparar resultados. Entre los inconvenientes producidos por un elevado grado de desbalance en las fases del sistema, se consideran la minimización de las pérdidas técnicas y la mejora del perfil de tensiones. Ambos aspectos, relacionados con el uso racional de la energía propiciado desde el lado de la oferta, son observados por la autoridad regulatoria. Se presenta, adicionalmente, un modelo matheurístico que combina el enfoque clásico del problema, con el uso de programación lineal entera-mixta con las dos metaheurísticas introducidas, FEPSO GIST y FAFS. Se comparan los resultados de aplicar los modelos sobre el mismo SDEE BT considerado en el enfoque resuelto vía FPSO. En esta Parte I se abordan los antecedentes y desarrollos teóricos requeridos en la aplicación.

  13. Isolados de Dicyma pulvinata em estromas de Microcyclus ulei em seringueira Dicyma pulvinata isolates colonizing Microcyclus ulei stromata in rubber

    Directory of Open Access Journals (Sweden)

    Sueli Corrêa Marques de Mello

    2006-02-01

    Full Text Available Dicyma pulvinata é um eficiente agente de biocontrole de Microcyclus ulei, causador do mal-das-folhas da seringueira. O objetivo deste trabalho foi obter isolados com grande potencial antagônico. Em levantamentos realizados em 14 municípios produtores de borracha, localizados nos Estados do Acre, Amazonas, Bahia, Mato Grosso, Pará e Rondônia, obtiveram-se 52 isolados de D. pulvinata. O fungo antagônico, isolado diretamente em meio de cultura de batata-dextrose-ágar (BDA, foi identificado com base na morfologia dos conídios e conidióforos e preservado pelos métodos da liofilização, congelamento à temperatura de -80ºC e criopreservação em nitrogênio líquido, a fim de manter as características morfológicas e patogênicas dos isolados. O efeito antagônico foi testado por meio de inoculações de D. pulvinata em lesões de Fusicladium macrosporum induzidas em plantas de seringueira previamente infectadas. Todos os isolados foram incorporados à coleção de fungos da Embrapa Recursos Genéticos e Biotecnologia.Dicyma pulvinata is an efficient biocontrol agent of Microcyclus ulei, causal agent of South American leaf blight. The objective of this work was to obtain strongly antagonistic isolates. A survey was carried out in rubber plantations located in 14 municipalities in the Sates of Acre, Amazonas, Bahia, Mato Grosso, Pará and Roraima, Brazil, obtaining 52 isolates of D. pulvinata. The antagonistic fungus was isolated on potato-dextrose-agar (PDA plates and identified based on morphological characteristics of conidiophores and conidia, and colony appearance. The antagonic effect was tested by inoculating D. pulvinata on Fusicladium macrosporum lesions induced on rubber plants, previously. In order to maintain the morphological and pathogenic traits, fungus isolates were preserved by lyophilization, deep freeze (-80ºC and cryogeny. All isolates were introduced into Embrapa Recursos Genéticos e Biotecnologia fungus collection.

  14. Teateid tulevikuköögist / Margit Aedla

    Index Scriptorium Estoniae

    Aedla, Margit, 1970-

    2007-01-01

    Electroluci 2006. a. disainiauhinna pälvinud ideetooted: I koht - innovaatiline toiduhoidja Nevale, Metin Kaplan, II - infrapunatehnoloogial põhinev Organic Cook, Brian Law, III - energiasäästlik ja informatiivne pliit Vessto, Eduardo Altamirano, finaali jõudnud töö - maitsetaimede inkubaator HydroSphera

  15. Gist of making reports on management of weighing

    International Nuclear Information System (INIS)

    1981-01-01

    This guide was published by the Nuclear Material Management Center under the supervision by the Nuclear Safety Bureau, Science and Technology Agency, and it gives instruction on the points when the reports on the management of nuclear materials are written. The contents are as follows. 1. Report of rounding adjustment: Examples of making reports (1) when rounding adjustment is made, (2) when rounding adjustment is not made, (3) in the case of changing to the method reporting book values as they are. 2. Report of nuclear materials of small amount. 3. Report of shipper- receiver difference: (1) Writing material balance reports in the case of no SR/D, (2) report of rebatching in SR/D-material balance areas, (3) report of SR/D in SR/D-material balance areas. 4. Report of category change: (1) Report of category change in one material balance report without dividing into each element, (2) report by dividing into the material balance report for each element. 5. Report of weight difference arising from rebatching. 6. Other points of caution when reports are written: (1) Report of inventory change dated same as the day of determining physical inventory, (2) report formats. (Kako, I.)

  16. Mosaiikpilte Norramaa köögist / Moonika Siimets

    Index Scriptorium Estoniae

    Siimets, Moonika, 1980-

    2009-01-01

    Norra reisist: Väiketootja Inger Rosenfeldi juustu edust Prantsusmaal, Ameerikas ja Norras; 1993. aasta kokandusolümpia "Bocuse d`Or" võitjast Bent Stiansenist; norralaste toitumisharjumustest; Preikestolen Fjellstue ökomajas asuva turismikeskuse restoranis pakutavatest roogadest.

  17. "Kalevipoeg" rootsi keeles / Juhan Mägiste ; ill. Erik Haamer

    Index Scriptorium Estoniae

    Mägiste, Juhan

    2000-01-01

    rets. rmt.: Kalevipoeg: Estlands nationalepos/samlad och på estniska utgiven av. Fr. R. Kreutzwald; i svensk tolkning av Alex Milits; illustrationer av Erik Haamer. Borås: Invandrarförlaget, 1999. 325 lk. : ill

  18. Ad gist : Ad communication in a single eye fixation

    NARCIS (Netherlands)

    Pieters, R.; Wedel, M.

    2012-01-01

    Most ads in practice receive no more than a single eye fixation. This study investigates the limits of what ads can communicate under such adverse exposure conditions. We find that consumers already know at maximum levels of accuracy and with high degree of certainty whether something is an ad or is

  19. Beyond scene gist: Objects guide search more than scene background.

    Science.gov (United States)

    Koehler, Kathryn; Eckstein, Miguel P

    2017-06-01

    Although the facilitation of visual search by contextual information is well established, there is little understanding of the independent contributions of different types of contextual cues in scenes. Here we manipulated 3 types of contextual information: object co-occurrence, multiple object configurations, and background category. We isolated the benefits of each contextual cue to target detectability, its impact on decision bias, confidence, and the guidance of eye movements. We find that object-based information guides eye movements and facilitates perceptual judgments more than scene background. The degree of guidance and facilitation of each contextual cue can be related to its inherent informativeness about the target spatial location as measured by human explicit judgments about likely target locations. Our results improve the understanding of the contributions of distinct contextual scene components to search and suggest that the brain's utilization of cues to guide eye movements is linked to the cue's informativeness about the target's location. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  20. Surgery and imatinib therapy for liver oligometastasis of GIST: a study of Japanese Study Group on GIST.

    Science.gov (United States)

    Kanda, Tatsuo; Masuzawa, Toru; Hirai, Toshihiro; Ikawa, Osamu; Takagane, Akinori; Hata, Yasuhiro; Ojima, Hitoshi; Sodeyama, Harutsugu; Mochizuki, Izumi; Ishikawa, Takashi; Kagimura, Tatsuo; Nishida, Toshirou

    2017-04-01

    We conducted a multicenter prospective study to clarify the efficacy and safety of surgery and imatinib for liver oligometastasis of gastrointestinal stromal tumors. Eligible gastrointestinal stromal tumor patients were enrolled in the surgery trial or the imatinib trial. Primary endpoints were recurrence-free survival and progression-free survival, respectively. The trials were prematurely terminated due to amendment of guidelines for adjuvant imatinib therapy and low patient accrual. In the surgery trial, all the six patients showed hepatic recurrence: median recurrence-free survival was 145 days (range: 62-1366 days). Of the five patients receiving salvage imatinib therapy, two showed progressive disease although no death was observed. Of the five patients enrolled in the imatinib trial, one died of pneumonia after progressive disease, and four had not shown progressive disease as of last visit. The results suggest that liver oligometastasis of gastrointestinal stromal tumor may not be controllable by surgery alone and require concomitant imatinib therapy. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  1. Estudo histológico e parasitológico do trato gastrintestinal de cães infectados com Leishmania (Leishmania) chagasi

    OpenAIRE

    Aldair Junio Woyames Pinto

    2011-01-01

    São poucas as descrições das alterações patológicas e parasitológicas relacionadas ao envolvimento do trato gastrointestinal (TGI) na leishmaniose visceral canina e, sobretudo considerando-se o TGI de forma sistemática. Assim, neste trabalho objetivou-se um estudo sistemático, clínico, anatomopatológico e parasitológico do TGI de cães naturalmente infectados com Leishmania (Leishmania) chagasi provenientes da região metropolitana de Belo Horizonte, MG. Após confirmação sorológica (RIFI e ELIS...

  2. Gastrintestinal helminths Of Cerdocyon thous (Linnaeus, 1766 -Smith, 1839 from the caatinga area of the Paraíba State, Brazil

    Directory of Open Access Journals (Sweden)

    Roberto César Lima

    2013-12-01

    Full Text Available The crab eating fox, Cerdocyon thous (Linnaeus, 1766 – Smith, 1839, is a medium sized canid which is found in almost every region of Brazil. It is the only registered native canid specie to be found in the semi-arid Northeastern region of the country. This study had as its objectives: the identification of the helminth fauna common to Cerdocyon thous found in the Caatinga of the state of Paraíba; and the determination of the ecological indications of helminthic infection, hoping to make a favourable addition to the understanding of this little known biome. In this study, 58 animals that were found as ‘roadkill’ on the highways in the municipality of Patos were used. The gastrointestinal helminths from these animals were colected. All the animals in this study were infected with helminths. 16 species of helminths were identified, two being trematodes, one being a cestode, one being an acanthocephalus, and the remaining twelve being nematodes. In this study a new specie, named Pterygodermatites pluripectinata n. sp. Was discovered and its host and location described.

  3. Tamanho relativo dos órgãos internos e do trato gastrintestinal de bovinos Zebu e mestiços leiteiros em sistema de recria

    Directory of Open Access Journals (Sweden)

    Backes Alfredo Acosta

    2006-01-01

    Full Text Available Utilizaram-se 12 bovinos machos castrados, com peso vivo médio de 257kg, sendo quatro zebu e oito mestiços leiteiros (quatro fraction one-half sangue Holandês x Gir e quatro fraction one-half sangue Holandês x Guzerá. Foram pesados e distribuídos em dois tratamentos (zebu e mestiços leiteiros, em fase de recria. Os animais foram avaliados até atingirem 340kg de peso vivo. O volumoso utilizado foi o feno de capim Tifton 85 (Cynodon dactylon. Por ocasião do abate foram coletadas amostras de rúmen, retículo, omaso, abomaso e intestinos, após o seu esvaziamento e limpeza, obtendo-se ainda os pesos e amostras de sangue, pele, pés, cabeça, fígado, rins, pulmões, língua, baço e gordura interna (mesentério e gorduras perirenal e pericardíaca. O peso do corpo vazio (PCVZ foi obtido pela soma dos pesos da carcaça, sangue, pele, pés, rabo, vísceras e órgãos. Na fase de recria e engorda, os animais zebu apresentaram a pele e o conjunto cabeça-pés-pele mais pesado do que os mestiços leiteiros. Também apresentaram os órgãos rins, baço, coração e língua mais leves do que dos mestiços. O conjunto rúmen-retículo-omaso-abomaso e os teores de gordura mesentérica e interna não apresentaram diferença entre animais mestiços leiteiros e zebu.

  4. Efeitos da Salmonella Enteritidis experimentalmente inoculada na saúde gastrintestinal de perus Effects of experimentally inoculated Salmonella Enteritidis on the gastrointestinal health of turkeys

    Directory of Open Access Journals (Sweden)

    Carla Yoko Tanikawa de Andrade

    2012-03-01

    Full Text Available Avaliaram-se os efeitos de Salmonella Enteritidis sobre a colonização e o desenvolvimento do trato intestinal, a conversão alimentar e o ganho de peso em perus. Um total de 135 perus de corte de 1 dia foi distribuído em três tratamentos: controle; perus oriundos de ovos inoculados com Salmonella Enteritidis via casca e perus desafiados com água de bebida com Salmonella Enteritidis. Aos 10, 20 e 28 dias, avaliaram-se as variáveis de desempenho e coletaram-se amostras para avaliação bacteriana, biometria e histomorfometria. Realizaram-se também, nos dias 1, 15 e 28 de idade, coletas de mecônio/excretas de todas as aves. A colonização intestinal aumentou durante a fase inicial quando Salmonella foi inoculada via casca. O intestino apresentou maior peso ao 1º, 10º e 28º dias quando Salmonella esteve presente, sem diferença no comprimento. Salmonella Enteritidis foi capaz de colonizar o trato intestinal, estabelecer infecção, reduzir o desempenho das aves e modificar as estruturas celulares do intestino. A contaminação da casca do ovo antes da incubação propiciou a ocorrência de infecções ao nascimento, e a frequência de isolamento de Salmonella Enteritidis persistiu até 28 dias de idade. A inoculação de Salmonella pela água de bebida gerou aves infectadas, porém com menor nível de infecção com o avançar da idade. O desempenho de aves inoculadas com Salmonella Enteritidis é menor e isso confirma potenciais prejuízos para a produção avícola.The effects of Salmonella Enteritidis on the colonization and development of the intestinal tract, feed conversion and weight gain were evaluated. A total of 135 day old turkeys were assigned to three treatments: control; turkeys from eggs inoculated with Salmonella Enteritidis via shell and turkeys challenged with drinking water with Salmonella Enteritidis. At 10, 20 and 28 days, the performance variables were evaluated and samples were collected to perform bacterial assessment, biometrics and histomorphometry. On days one, 15 and 28, samples of meconium/excreta were collected from all birds. The intestinal colonization increased during the initial phase when Salmonella was inoculated via eggshell. The intestine showed greater weight on the first, tenth and 28th days when Salmonella was present, with no differences regarding the intestine length. Salmonella Enteritidis was able to colonize the intestinal tract, establish infection, reduce bird performance and modify the cellular structures of the intestine. Contamination of the eggshell before hatching generated birds susceptible to infection at birth and the frequency of isolation of Salmonella Enteritidis persisted until 28 days of age. Salmonella inoculation by drinking water generated infected birds, but with less recovery of the pathogen with age increase. Inoculated birds showed inferior performance, confirming the potential damage to poultry production.

  5. Attention to Global Gist Processing Eliminates Age Effects in False Memories

    Science.gov (United States)

    Odegard, Timothy N.; Holliday, Robyn E.; Brainerd, Charles J.; Reyna, Valerie F.

    2008-01-01

    Counterintuitive age increases have been reported for the Deese-Roediger-McDermott (DRM) false memory illusion. The current theoretical explanation of this effect assumes that it is due to age increases in spontaneous interconnection of DRM list words' meanings. To test this explanation, 11-year-olds and young adults studied DRM lists under…

  6. (GIS-T) application for traffic congestion analyses in the De

    African Journals Online (AJOL)

    generation known as the 'traditional stopwatch and traffic congestion registration ... transportation safety analysis, travel demand analysis, traffic monitoring and .... many transportation agencies use distance measuring instruments (DMIs) in their probe vehicles. ..... Spatial Implications of the Tuberculosis DOTS Strategy in.

  7. A gist of comprehensive review of hadronic chemistry and its applications

    Energy Technology Data Exchange (ETDEWEB)

    Tangde, Vijay M. [Post Graduate Teaching Department of Chemistry, Rashtrasant Tukadoji Maharaj Nagpur University, Amravati Road Campus, NAGPUR - 440 033, India, Email: vijaytn6@gmail.com (India)

    2015-03-10

    20{sup th} century theories of Quantum Mechanics and Quantum Chemistry are exactly valid only when considered to represent the atomic structures. While considering the more general aspects of atomic combinations these theories fail to explain all the related experimental data from first unadulterated axiomatic principles. According to Quantum Chemistry two valence electrons should repel each other and as such there is no mathematical representation of a strong attractive forces between such valence electrons. In view of these and other insufficiencies of Quantum Chemistry, an Italian-American Scientist Professor Ruggero Maria Santilli during his more than five decades of dedicated and sustained research has denounced the fact that quantum chemistry is mostly based on mere nomenclatures. Professor R M Santilli first formulated the iso-, geno- and hyper- mathematics [1, 2, 3, 4] that helped in understanding numerous diversified problems and removing inadequacies in most of the established and celebrated theories of 20th century physics and chemistry. This involves the isotopic, genotopic, etc. lifting of Lie algebra that generated Lie admissible mathematics to properly describe irreversible processes. The studies on Hadronic Mechanics in general and chemistry in particular based on Santilli’s mathematics[3, 4, 5] for the first time has removed the very fundamental limitations of quantum chemistry [2, 6, 7, 8]. In the present discussion, a comprehensive review of Hadronic Chemistry is presented that imparts the completeness to the Quantum Chemistry via an addition of effects at distances of the order of 1 fm (only) which are assumed to be Non-linear, Non-local, Non-potential, Non-hamiltonian and thus Non-unitary, stepwise successes of Hadronic Chemistry and its application in development of a new chemical species called Magnecules.

  8. Gist in time: Scene semantics and structure enhance recall of searched objects.

    Science.gov (United States)

    Josephs, Emilie L; Draschkow, Dejan; Wolfe, Jeremy M; Võ, Melissa L-H

    2016-09-01

    Previous work has shown that recall of objects that are incidentally encountered as targets in visual search is better than recall of objects that have been intentionally memorized (Draschkow, Wolfe, & Võ, 2014). However, this counter-intuitive result is not seen when these tasks are performed with non-scene stimuli. The goal of the current paper is to determine what features of search in a scene contribute to higher recall rates when compared to a memorization task. In each of four experiments, we compare the free recall rate for target objects following a search to the rate following a memorization task. Across the experiments, the stimuli include progressively more scene-related information. Experiment 1 provides the spatial relations between objects. Experiment 2 adds relative size and depth of objects. Experiments 3 and 4 include scene layout and semantic information. We find that search leads to better recall than explicit memorization in cases where scene layout and semantic information are present, as long as the participant has ample time (2500ms) to integrate this information with knowledge about the target object (Exp. 4). These results suggest that the integration of scene and target information not only leads to more efficient search, but can also contribute to stronger memory representations than intentional memorization. Copyright © 2016 Elsevier B.V. All rights reserved.

  9. Cost-Effectiveness Analysis of Regorafenib for Gastrointestinal Stromal Tumour (GIST) in Germany.

    Science.gov (United States)

    Tamoschus, David; Draexler, Katja; Chang, Jane; Ngai, Christopher; Madin-Warburton, Matthew; Pitcher, Ashley

    2017-06-01

    No study has compared the cost-effectiveness of active treatment options for unresectable or metastatic gastrointestinal stromal tumours in patients who progressed on or are intolerant to prior treatment with imatinib and sunitinib. The aim of this study was to estimate the cost-effectiveness of regorafenib compared to imatinib rechallenge in this setting in Germany. Hazard ratios for progression-free (PFS) and overall survival (OS) with regorafenib versus imatinib rechallenge were estimated by indirect comparison. A state distribution model was used to simulate progression, mortality and treatment costs over a lifetime horizon. Drug acquisition costs and utilities were derived from clinical trial data and published literature; non-drug costs were not included. The outcomes measured were treatment costs, life-years (LYs) and quality-adjusted life-years (QALYs). The indirect comparison suggested that median PFS and OS were longer with regorafenib compared to imatinib but results were not statistically significant. Regorafenib versus imatinib rechallenge was estimated to have hazard ratios of 0.58 (95% CI 0.31-1.11) for PFS and 0.77 (95% CI 0.34-1.77) for OS, with substantial uncertainty due to the rarity of the disease and small number of patients within the trials. Regorafenib treatment per patient over a lifetime horizon provided an additional 0.61 LYs and 0.42 QALYs over imatinib rechallenge, with additional direct drug costs of €8,773. The incremental cost-effectiveness ratio was €21,127 per QALY gained. At a cost-effectiveness threshold of €50,000 per QALY, regorafenib had a 67% probability of being cost-effective. Based on the currently available clinical data, this analysis suggests that regorafenib is cost-effective compared with imatinib rechallenge in Germany.

  10. The role of surgery in an imatinib-resistant GIST liver secondary

    African Journals Online (AJOL)

    deoxyDglucose positron emission tomography (FDGPET) scan excluded distant metastases. A laparotomy was performed with a wedge resection of an 8а╫а7 cm lesion of the greater curve of the stomach. The immunohistochemistry identified CD117 and CD34 with an exon 11 deletion mutation and a high mitotic index.

  11. Pärnits kummutab jutud Ülemiste City müügist / Jaana Pikalev

    Index Scriptorium Estoniae

    Pikalev, Jaana

    2010-01-01

    AS Mainor omanikeringi kuuluv Ülo Pärnits kummutab jutud, nagu sooviks firma Ülemiste City maha müüa. Uus Maa Kinnisvaragrupp OÜ tegevjuhi Jaanus Lauguse väitel on pool Ülemiste Cityst välja arendamata, tema hinnangul on mõistlik Ülemiste City riskide maandamiseks müüa mõnele pikaajalisele investorile

  12. Bioetanooli saab prügist / Mette Hedegaard Thomsen ; interv. Sten-Aleks Pihlak

    Index Scriptorium Estoniae

    Thomsen, Mette Hedegaard

    2008-01-01

    Taani Tehnikaülikooli Riso laboratooriumi teaduri Mette Hedegaard Thomseni sõnul suudab teise põlvkonna bioetanoolitehas teha kütust kõikvõimalikest jäätmetest ning on samas palju loodussõbralikum. Kommenteerib Robert Antropov

  13. Havipüügist hilissügisel jerklantidega / Pavel Margulis, Marek Sukk, Marko Zlatin

    Index Scriptorium Estoniae

    Margulis, Pavel

    2015-01-01

    Jerkimise kohta arvavad paljud kalastajad, et see on üks keeruline püügiviis, mida on raske õppida ning mis nõuab spetsiaalset ja kallist varustust. Oma kogemusi jagavad jergipüüdjad, kes on nende lantidega Eesti vetest muljetavaldavaid havisid välja tõmmanud

  14. A gist of comprehensive review of hadronic chemistry and its applications

    International Nuclear Information System (INIS)

    Tangde, Vijay M.

    2015-01-01

    20 th century theories of Quantum Mechanics and Quantum Chemistry are exactly valid only when considered to represent the atomic structures. While considering the more general aspects of atomic combinations these theories fail to explain all the related experimental data from first unadulterated axiomatic principles. According to Quantum Chemistry two valence electrons should repel each other and as such there is no mathematical representation of a strong attractive forces between such valence electrons. In view of these and other insufficiencies of Quantum Chemistry, an Italian-American Scientist Professor Ruggero Maria Santilli during his more than five decades of dedicated and sustained research has denounced the fact that quantum chemistry is mostly based on mere nomenclatures. Professor R M Santilli first formulated the iso-, geno- and hyper- mathematics [1, 2, 3, 4] that helped in understanding numerous diversified problems and removing inadequacies in most of the established and celebrated theories of 20th century physics and chemistry. This involves the isotopic, genotopic, etc. lifting of Lie algebra that generated Lie admissible mathematics to properly describe irreversible processes. The studies on Hadronic Mechanics in general and chemistry in particular based on Santilli’s mathematics[3, 4, 5] for the first time has removed the very fundamental limitations of quantum chemistry [2, 6, 7, 8]. In the present discussion, a comprehensive review of Hadronic Chemistry is presented that imparts the completeness to the Quantum Chemistry via an addition of effects at distances of the order of 1 fm (only) which are assumed to be Non-linear, Non-local, Non-potential, Non-hamiltonian and thus Non-unitary, stepwise successes of Hadronic Chemistry and its application in development of a new chemical species called Magnecules

  15. Gastric stromal tumor presenting as a right upper quadrant abdominal mass. Importance of a correct radiological differential diagnosis; Tumor del estroma gastrico presentado como una masa en el hemiabdomen superior derecho. Importancia de un correcto diagnostico diferencial radiologico

    Energy Technology Data Exchange (ETDEWEB)

    Tudela, X.; Garcia-Vila, J. H.; Jornet, J. [Hospital General de Castello. Castello de la Plana (Spain)

    2001-07-01

    Stromal tumors of the gastrointestinal tract encompass a group of neoplasms representing 1% to 3% of all digestive system tumors. When located in the stomach, their tendency to exhibit and exophytic growth pattern makes it necessary to establish the differential diagnosis with respect to other gastric tumors (lymphoma, exophytic adenocarcinoma) and nongastrointestinal masses. We present a case that illustrated the difficulties associated with the imaging diagnosis of these lesions and the importance of modern radiological techniques (helical computed tomography and magnetic resonance) and the correct interpretation on the part of radiologists to orient pathologists and clinicians toward the diagnosis and proper treatment. (Author) 10 refs.

  16. Ceratectomia fotorrefrativa associada à ceratotomia lamelar pediculada (LASIK para correção de miopias, com ou sem secagem do estroma Photorefractive keratectomy associated with lamellar keratotomy (LASIK for correction of myopia, with or without drying the stroma

    Directory of Open Access Journals (Sweden)

    Cesar K. Suzuki

    2000-12-01

    Full Text Available Objetivo: Avaliar os resultados clínicos da ceratectomia fotorrefrativa associada à ceratotomia lamelar pediculada (LASIK, para miopia moderada e alta, com ou sem secagem do leito estromal durante a foto-ablação. Pacientes e Métodos: Estudo retrospectivo de 39 olhos de 30 pacientes submetidos a LASIK sem secagem do leito estromal durante a foto-ablação no período de abril de 1996 a abril de 1997 (Grupo I e 42 olhos de 28 pacientes com secagem do leito estromal durante a foto-ablação a cada 80 pulsos, no período de abril de 1997 a setembro de 1997 (Grupo II. Após a ceratotomia lamelar pediculada corneana com um microcerátomo automatizado (Chiron Corneal Shaper ®, foi realizada a foto-ablação com excimer laser de fluoreto de argônio de 193 nm da Summit modelo Apex Plus®. Em 2 olhos do Grupo I, a foto-ablação não foi realizada, devido a complicações durante a ceratotomia lamelar. Resultados: O tempo médio de seguimento pós-operatório foi de 8,7 meses no Grupo I e 7,7 meses no Grupo II. A média de tratamento foi de -10,81D (±2,38 no grupo I e -8,73D (±2,82 no grupo II. As médias das variações dos equivalentes esféricos obtidos em relação ao tratamento desejado nos meses 1, 3, 6 e 12 foram respectivamente, -0,96D (±1,19, -1,19D (±1,37, -1,06D (±1,41 e -1,10D (±0,66 no Grupo I e -0,23D (±1,02, -0,41D (±1,34, -0,75D (±1,16 e -1,03D (±1,31 no Grupo II. Três olhos do total (3,7%, todos do Grupo I, perderam 2 ou mais linhas de visão. Na visita mais recente, 17 olhos (45,9% do Grupo I e 31 olhos (73,8% do Grupo II apresentaram Acuidade Visual sem correção de 20/40 ou melhor. Ocorreram 4 complicações intra-operatórias no grupo I, sendo que 2 casos tiveram a foto-ablação não-efetuada e uma complicação intra-operatória no Grupo II. Conclusão: A secagem do leito estromal possibilitou recuperação visual mais rápida, devido a menor hipocorreção primária. O seguimento a longo prazo não evidenciou diferenças estatisticamente significantes entre os dois tratamentos.Purpose: To evaluate the clinical results of LASIK for moderate and high degrees of myopia, with and without drying the stroma during photoablation. Patient and Methods: Retrospective analysis of 39 eyes of 30 patients submitted to LASIK, without drying the stroma during photoablation, in the period from April 1996 to April 1997 (Group I and analysis of 42 eyes of 28 patients with drying of the stromal bed at each 80 pulses during photoablation in the period of April of 1997 to September of 1997 (Group II. After lamellar keratotomy with an automated microkeratome (Chiron Corneal Shaper ®, photoablation with fluoride-argon excimer laser, 193 nm, Summit model Apex Plus ® was carried out. In 2 eyes of the Group I, the photoablation was not possible due to compli- cations during the lamellar keratotomy. Results: The average follow-up was 8.7 months in Group I and 7.7 months in Group II. The mean treatment was -10.81D (±2.38 in Group I and -8.73D (±2.82 in Group II. The average variations of the achieved spherical equivalent in relation to the attempted treatment in months 1, 3, 6 and 12 were respectively, -0.96D (±1.19, -1.19D (±1.37, -1.06D (±1.41 and -1.10D (±0.66 in Group I and -0.23D (±1.02, -0.41D (±1.34, -0.75D (±1.16 and -1.03D (±1.31 in Group II. On the last visit 17 eyes (45.9% of Group I and 31 eyes (73.8% of Group II showed uncorrected VA of 20/40 or better. Four intraoperative complications occurred in Group I, in 2 of them the photoablations were not performed and one intraoperative complication occurred in Group II. There was a loss of 2 or more lines in 3 eyes (3.7% ot Group I. Conclusion: Drying of the stroma led to a faster visual recovery due to smaller hypocorrection. No significant differences were observed in the long-term follow-up.

  17. Associação de técnicas na estimativa da nematodeose gastrintestinal de caprinos Mestiços Anglo Nubiano Association of techniques for estimation of gastrointestinal nematodeosis in Anglo Nubian crossbred goats

    Directory of Open Access Journals (Sweden)

    Marina Santana Rossi Peixoto

    2011-06-01

    Full Text Available A associação de métodos diretos como o exame de fezes, e indiretos como os métodos FAMACHA© e do micro-hematócrito, podem facilitar na classificação de caprinos com relação à resistência e suscetibilidade aos nematoides gastrintestinais. Sessenta caprinos foram avaliados pelo grau FAMACHA©, pela contagem de ovos nas fezes (OPG e volume globular. Por análise de agrupamento hierárquico ascendente foram selecionados aqueles com potencial para resistência aos nematoides gastrintestinais (n=10 e os com potencial para suscetibilidade (n=10. Os caprinos com potencial para suscetibilidade apresentaram os maiores valores do grau FAMACHA©, do OPG, do número de larvas infectantes (L3 de Haemonchus e da concentração de fibrinogênio, e os menores valores de volume globular, proteína total e escore corporal. Foi demonstrado que os graus 3 e 4 foram mais predominantes nos animais com potencial para suscetibilidade, com os percentuais válidos de 45,5 e 30,5 respectivamente, e os graus 2 e 3 nos potenciais para suscetibilidade, com os respectivos percentuais válidos de 34,4 e 51,9. Observou-se que 58,4% dos animais do potencial para suscetibilidade e 90,6% dos potenciais para resistência estavam entre os graus FAMACHA© 1 e 3, o que mostra a maior tendência dos potenciaias para resistência em tolerar a infecção contra nematoides gastrintestinais. O total de estádios jovens e adultos de nematoides dos caprinos com potencial para suscetibilidade foi 2660,4 contra 1669,3 dos potenciaias para resistência. A associação dessas técnicas é um modelo importante na abordagem das nematodeoses em caprinos em condições do semiárido.The association of direct methods, as faecal exams, and indirect methods such as FAMACHA© system and microhematocrit, can facilitate classification of resistant and suscetible goats to gastro-intestinal nematodes. Sixty goats were evaluated using FAMACHA© score, faecal worm egg counts (EPG and packed cell volum. Ten animals with potential to resistance and ten with potential to susceptibility to gastrointestinal nematode were selected by ascendent hierarchic groupment analysis. Goats from potential do susceptibility group presented the highest FAMACHA© score, EPG, Haemonchus L3 number and serum fibrinogem concentration, and the lowest packed cell volum, total serum protein and body score. The FAMACHA© score, 3 and 4, were the most predominant in potential do susceptibility animals with valid percentages of 45.5 and 30.5, respectively and degrees 2 and 3 in potential to resistance group, with respective valid percentages of 34.4 and 51.9. It was also observed that 58.4% of the potential do susceptibility animals and 90.6% of the potential to resistance are between FAMACHA© score 1 and 3, showing tendency of the potential to resistance to tolerate infection to gastro-intestinal nematode. The total number of immature and adult nematode obtained from potential to susceptibility goats was 2660.41 against 1669.34 in potential to resistance group. The association of these techniques is an important model to access nematodiosis in goats under semi-arid conditions.

  18. Radiographic anatomy aspects and gastrointestinal transit time in Podocnemis unifilis troschel, 1848 (Testudines, Podocnemididae). = Aspectos anátomo-radiográficos e tempo de trânsito gastrintestinal em Podocnemis unifilis troschel, 1848 (Testudines, Podocnemididae)

    OpenAIRE

    Fernando Moraes Machado Brito; Lucélia Gonçalves Vieira; Cirilo Antônio Paula Lima; Carlos Gomes Ferreira; José Guilherme Souza Pinto; André Luiz Quagliatto Santos

    2010-01-01

    The present study analyzed the radiographic anatomy and determined thegastrointestinal transit time of Podocnemis unifilis. We used ten animals belonging to LAPAS from the Federal University of Uberlândia, Uberlândia, Minas Gerais State, Brazil. The animals were orally fed with a barium sulphate suspension at 10 mL kg-1 mixed with mineral oil, at a ratio of 70% of barium sulphate for 30% of mineral oil. Afterwards, the animals underwent radiography in a dorsum ventriloquoal position, with the...

  19. GIST with a twist--upregulation of PDGF-B resulting in metachronous gastrointestinal stromal tumor and dermatofibrosarcoma protuberans.

    LENUS (Irish Health Repository)

    McCarthy, Colin J

    2010-02-01

    A 61-year-old male was referred following an incidental radiological discovery of an intra-abdominal mass. His medical history included excision of a lumbar dermatofibrosarcoma protuberans (DFSP) 5 years previously. A CT scan of the abdomen revealed a mass arising from the greater curvature of the stomach. Upper GI endoscopy was normal. He underwent successful laparoscopic resection of this mass.

  20. Negative affect promotes encoding of and memory for details at the expense of the gist: affect, encoding, and false memories.

    Science.gov (United States)

    Storbeck, Justin

    2013-01-01

    I investigated whether negative affective states enhance encoding of and memory for item-specific information reducing false memories. Positive, negative, and neutral moods were induced, and participants then completed a Deese-Roediger-McDermott (DRM) false-memory task. List items were presented in unique spatial locations or unique fonts to serve as measures for item-specific encoding. The negative mood conditions had more accurate memories for item-specific information, and they also had fewer false memories. The final experiment used a manipulation that drew attention to distinctive information, which aided learning for DRM words, but also promoted item-specific encoding. For the condition that promoted item-specific encoding, false memories were reduced for positive and neutral mood conditions to a rate similar to that of the negative mood condition. These experiments demonstrated that negative affective cues promote item-specific processing reducing false memories. People in positive and negative moods encode events differently creating different memories for the same event.

  1. Failing to Get the Gist of What’s Being Said: Background Noise Impairs Higher Order Cognitive Processing

    Directory of Open Access Journals (Sweden)

    John Everett Marsh

    2015-05-01

    Full Text Available A dynamic interplay is known to exist between auditory processing and human cognition. For example, prior investigations of speech-in-noise have revealed there is more to learning than just listening: Even if all words within a spoken list correctly heard in noise, later memory for those words is typically impoverished. At such low signal-to-noise ratios when listeners could identify words, those participants could not necessarily remember those words. These investigations supported a view that there is a gap between the intelligibility of speech and memory for that speech. Here, the notion was that this gap between speech intelligibility and memorability is a function of the extent to which the spoken message seizes limited immediate memory resources (e.g., Kjellberg, Ljung, & Hallman, 2008. Accordingly, the more difficult the processing of the spoken message, the less resources are available for elaboration, storage, and recall of that spoken material. However, it was not previously known how increasing that difficulty affected the memory processing of semantically rich spoken material. This investigation showed that noise impairs higher levels of cognitive analysis. A variant of the Deese-Roediger-McDermott procedure that encourages semantic elaborative processes was deployed. On each trial, participants listened to a 36-item list comprising 12 words blocked by each of 3 different themes. Each of those 12 words (e.g., bed, tired, snore… was associated with a critical lure theme word that was not presented (e.g., sleep. Word lists were either presented without noise or at a signal-to-noise ratio of 5 decibels upon an A-weighting. Noise reduced false recall of the critical words, and decreased the semantic clustering of recall. Theoretical and practical implications are discussed.

  2. The Role of Gist and Verbatim Memory in Complex Decision Making: Explaining the Unconscious-Thought Effect

    Science.gov (United States)

    Abadie, Marlène; Waroquier, Laurent; Terrier, Patrice

    2017-01-01

    Previous research showed that the "unconscious-thought effect", which refers to an improvement in complex decision making following a distraction period, was moderated by the presentation format of pieces of information about different options. The aim of the current study was to replicate this finding and further examine the memory…

  3. Failing to Get the Gist of What’s Being Said: Background Noise Impairs Higher Order Cognitive Processing

    OpenAIRE

    John Everett Marsh; John Everett Marsh; Robert eLjung; Anatole eNöstl; Emma eThreadgold; Tom A Campbell

    2015-01-01

    A dynamic interplay is known to exist between auditory processing and human cognition. For example, prior investigations of speech-in-noise have revealed there is more to learning than just listening: Even if all words within a spoken list correctly heard in noise, later memory for those words is typically impoverished. At such low signal-to-noise ratios when listeners could identify words, those participants could not necessarily remember those words. These investigations supported a view th...

  4. Failing to get the gist of what's being said: background noise impairs higher-order cognitive processing

    OpenAIRE

    Marsh, John E.; Ljung, Robert; N?stl, Anatole; Threadgold, Emma; Campbell, Tom A.

    2015-01-01

    A dynamic interplay is known to exist between auditory processing and human cognition. For example, prior investigations of speech-in-noise have revealed there is more to learning than just listening: Even if all words within a spoken list are correctly heard in noise, later memory for those words is typically impoverished. These investigations supported a view that there is a "gap" between the intelligibility of speech and memory for that speech. Here, the notion was that this gap between sp...

  5. Failing to get the gist of what's being said: background noise impairs higher-order cognitive processing.

    Science.gov (United States)

    Marsh, John E; Ljung, Robert; Nöstl, Anatole; Threadgold, Emma; Campbell, Tom A

    2015-01-01

    A dynamic interplay is known to exist between auditory processing and human cognition. For example, prior investigations of speech-in-noise have revealed there is more to learning than just listening: Even if all words within a spoken list are correctly heard in noise, later memory for those words is typically impoverished. These investigations supported a view that there is a "gap" between the intelligibility of speech and memory for that speech. Here, the notion was that this gap between speech intelligibility and memorability is a function of the extent to which the spoken message seizes limited immediate memory resources (e.g., Kjellberg et al., 2008). Accordingly, the more difficult the processing of the spoken message, the less resources are available for elaboration, storage, and recall of that spoken material. However, it was not previously known how increasing that difficulty affected the memory processing of semantically rich spoken material. This investigation showed that noise impairs higher levels of cognitive analysis. A variant of the Deese-Roediger-McDermott procedure that encourages semantic elaborative processes was deployed. On each trial, participants listened to a 36-item list comprising 12 words blocked by each of 3 different themes. Each of those 12 words (e.g., bed, tired, snore…) was associated with a "critical" lure theme word that was not presented (e.g., sleep). Word lists were either presented without noise or at a signal-to-noise ratio of 5 decibels upon an A-weighting. Noise reduced false recall of the critical words, and decreased the semantic clustering of recall. Theoretical and practical implications are discussed.

  6. GIST gástrico: revisión de la literatura a propósito de un caso.

    Directory of Open Access Journals (Sweden)

    Daniela V Blanco-Echezuría

    2010-08-01

    La sintomatología depende de la localización del proceso neoproliferativo, hallándose con mayor frecuencia en el estómago (60-70%. La supervivencia tras citorreducción R0 a 5 años es de 40% a 65%, con recurrencia del 20%; sin embargo, disminuye a 9-12 meses si la reducción fue incompleta.

  7. Long-Term Survival According to Histology and Radiologic Response to Preoperative Chemotherapy in 126 Patients Undergoing Resection of Non-GIST Sarcoma Liver Metastases.

    Science.gov (United States)

    Goumard, Claire; Marcal, Leonardo P; Wang, Wei-Lien; Somaiah, Neeta; Okuno, Masayuki; Roland, Christina L; Tzeng, Ching-Wei D; Chun, Yun Shin; Feig, Barry W; Vauthey, Jean-Nicolas; Conrad, Claudius

    2018-01-01

    Non-gastrointestinal stromal tumor sarcomas (NGSs) have heterogeneous histology, and this heterogeneity may lead to uncertainty regarding the prognosis of patients with liver metastases from NGS (NGSLM) and decision regarding their surgical management. Furthermore, the role of preoperative chemotherapy in treatment of NGSLM remains poorly defined. We investigated long-term survival and its correlation to response to preoperative chemotherapy in patients with NGSLM. Patients who underwent liver resection for NGSLM during 1998-2015 were identified. Clinical, histopathologic, and survival data were analyzed. Multivariate analysis was performed using a Cox proportional hazards model. 126 patients [62 (49%) with leiomyosarcoma] were included. Five-year overall survival (OS) and recurrence-free survival (RFS) rates were 49.3 and 14.9%, respectively. Survival did not differ by histologic subtype, primary tumor location, or use of preoperative or postoperative chemotherapy. NGSLM ≥ 10 cm and extrahepatic metastases at NGSLM diagnosis were the only independent risk factors for OS. In the 83 (66%) patients with metachronous NSGLM, disease-free interval > 6 months was associated with improved OS and RFS. Among the 65 patients (52%) who received preoperative chemotherapy, radiologic response according to Choi criteria specifically was associated with improved OS (p = 0.04), but radiologic response according to RECIST 1.1 criteria was not. Resection of NGSLM led to a 5-year OS rate of 49%, independent of histologic subtype and primary tumor location. Choi criteria (which take into account tumor density) are superior to RECIST 1.1 in assessing radiologic response and should be used to assess response to preoperative chemotherapy.

  8. KIT Mutation and Loss of 14q May Be Sufficient for the Development of Clinically Symptomatic Very Low-Risk GIST.

    Directory of Open Access Journals (Sweden)

    Olaf Karl Klinke

    Full Text Available The aim of this study was to determine the minimal set of genetic alterations required for the development of a very low risk clinically symptomatic gastro-intestinal stromal tumour within the stomach wall. We studied the genome of a very low-risk gastric gastro-intestinal stromal tumour by whole-genome sequencing, comparative genomic hybridisation and methylation profiling. The studied tumour harboured two typical genomic lesions: loss of the long arm of chromosome 14 and an activating mutation in exon 11 of KIT. Besides these genetic lesions, only two point mutations that may affect tumour progression were identified: A frame-shift deletion in RNF146 and a missense mutation in a zinc finger of ZNF407. Whilst the frameshift deletion in RNF146 seemed to be restricted to this particular tumour, a similar yet germline mutation in ZNF407 was found in a panel of 52 gastro-intestinal stromal tumours from different anatomical sites and different categories. Germline polymorphisms in the mitotic checkpoint proteins Aurora kinase A and BUB1 kinase B may have furthered tumour growth. The epigenetic profile of the tumour matches that of other KIT-mutant tumours. We have identified mutations in three genes and loss of the long arm of chromosome 14 as the so far minimal set of genetic abnormalities sufficient for the development of a very low risk clinically symptomatic gastric stromal tumour.

  9. MiR-221 and -222-based therapeutic approach in melanoma and GIST (Gastrointestinal Stromal Tumor): in vitro and in vivo preclinical studies

    Energy Technology Data Exchange (ETDEWEB)

    Care, A; Bonci, D [Department of Haematology, Oncology and Molecular Medicine, Istituto Superiore di Sanita, Rome (Italy); Peschle, C [IRCCS MultiMedica, Milan (Italy)

    2009-07-01

    Micro RNAs (miRs) are small ({approx}22 nucleotides) non coding RNAs involved in gene expression, as negative regulators of specific mRNA targets. Growing evidences indicated miR functional roles in all the main biological processes, including cancer where they can act as oncogenes as well as tumor suppressor genes. Several studies reported the involvement of miR- 221 and -222 in the induction and/or progression of different neoplasias. We have analyzed miR-221/-222 functional role in a panel of differently staged melanoma cell lines and primary bioptic samples, showing their capabilities to regulate two distinct, but functionally convergent pathways of melanocyte transformation through the cell cycle inhibitor p27Kip and c-kit receptor. We also demonstrated the lack of the tumor suppressor gene PLZF as a direct cause of miR-221/-222 up regulation in melanoma cells. In vitro and, more important, in vivo studies confirmed that suppression of miR-221/-222 strongly reduced melanoma growth and dissemination.

  10. MiR-221 and -222-based therapeutic approach in melanoma and GIST (Gastrointestinal Stromal Tumor): in vitro and in vivo preclinical studies

    International Nuclear Information System (INIS)

    Care, A.; Bonci, D.; Peschle, C.

    2009-01-01

    Micro RNAs (miRs) are small (∼22 nucleotides) non coding RNAs involved in gene expression, as negative regulators of specific mRNA targets. Growing evidences indicated miR functional roles in all the main biological processes, including cancer where they can act as oncogenes as well as tumor suppressor genes. Several studies reported the involvement of miR- 221 and -222 in the induction and/or progression of different neoplasias. We have analyzed miR-221/-222 functional role in a panel of differently staged melanoma cell lines and primary bioptic samples, showing their capabilities to regulate two distinct, but functionally convergent pathways of melanocyte transformation through the cell cycle inhibitor p27Kip and c-kit receptor. We also demonstrated the lack of the tumor suppressor gene PLZF as a direct cause of miR-221/-222 up regulation in melanoma cells. In vitro and, more important, in vivo studies confirmed that suppression of miR-221/-222 strongly reduced melanoma growth and dissemination

  11. Hemorragia digestiva alta secundária a hamartoma de glândulas de Brunner: relato de caso e revisão da literatura = Upper gastrintestinal bleeding due to Brunner’s gland hamartoma: case report and literature review

    Directory of Open Access Journals (Sweden)

    Lul, Rodrigo Mayer

    2013-01-01

    Conclusões: Apesar do hamartoma de glândulas de Brunner ser uma lesão benigna e rara, de crescimento indolente e comumente assintomática, pode provocar quadros graves como o descrito neste relato, devendo ser sempre lembrado como diagnóstico diferencial em casos de hemorragia digestiva alta

  12. Gastrointestinal transit after transverse colostomy: study of solid radiopaque markers progression and others clinical and radiological events - analysis of 20 cases; Transito gastrintestinal apos fechamento de transversostomia: estudo atraves da progressao de marcadores solidos radiopacos e de outros eventos clinicos e radiologicos - analise de 20 casos

    Energy Technology Data Exchange (ETDEWEB)

    Deutsch, Claudio Roberto

    1988-07-01

    The gastrointestinal transit was studied in 20 patients with loop transverse colostomies and previously normal colons. This analysis was performed through radiological observation of progression of 20 radiopaque pellets and measurements of its transit time in the various segments of the digestive tract. An evaluation of other related clinical and radiological events was carried out sentimentality's. In order to better understand the influence of the surgical procedure, the study was performed under similar dietary and supportive care conditions and standard radiological studies before and after the re-establishment of transit, thus enabling a comparison with the same individual. (author)

  13. Gastrointestinal stromal tumor of the vermiform appendix mimicking Meckel’s diverticulum: Case report with literature review

    Directory of Open Access Journals (Sweden)

    Jae Min Chun

    2016-01-01

    Conclusion: Primary appendiceal GIST occur at a very low rate and their symptoms are nonspecific. Accordingly, rare tumors of appendix including GISTs should be considered in the differential diagnosis of atypical symptoms or image findings.

  14. CT and MR imaging of gastrointestinal stromal tumor of stomach: a pictorial review

    OpenAIRE

    Gong, Jingshan; Kang, Wenyan; Zhu, Jin; Xu, Jianmin

    2012-01-01

    This pictorial review illustrates CT and MR imaging appearance of gastrointestinal stromal tumor (GIST) of the stomach and other lesions with similar imaging appearance. GIST of the stomach appears as well-defined enhanced masses with characteristics of subeppthial neoplasms. Majority are exophytic growth, but can also be of intra-luminal growth. GIST can growth into a large mass without gastrointestinal tract obstruction. Necrosis is often seen in GIST and results in heterogeneous enhancemen...

  15. ORIGINAL ARTICLE

    African Journals Online (AJOL)

    Patient population. The study ... The average sizes of the GIST were 8.7 cm, 5.4 cm and 5.9 ... By stratifying GISTs according to classes of risk, KIT mutation was shown in most of the ... (n = 13), epitheloid type (n = 10) and mixed populations .... were first applied to estimate the risk of aggressive GIST ..... Which is the optimal.

  16. Results of plasma N-terminal pro B-type natriuretic peptide and cardiac troponin monitoring in GIST patients do not support the existence of imatinib-induced cardiotoxicity

    NARCIS (Netherlands)

    Perik, P. J.; Rikhof, B.; de Jong, F. A.; Verweij, J.; Gietema, J. A.; van der Graaf, W. T. A.

    Background: Recently, case reports of patients treated with imatinib (imatinib mesylate; Gleevec (R); Glvec (R)) indicated that this tyrosine kinase inhibitor may induce cardiomyopathy. Consequently, careful cardiac monitoring was advocated for clinical studies. The purpose of this study was to

  17. Le vol sous l’œil des médecins légistes. Étude du concept de kleptomanie au cours du XIXe siècle

    OpenAIRE

    Bogani, Lisa

    2016-01-01

    Introduit en 1816 par le Dr Matthey, le concept de kleptomanie connait de multiples évolutions au cours du long xixe siècle. Alors qu’il parvient difficilement à se faire reconnaître des magistrats et des aliénistes du premier xixe siècle, il réussit finalement à se maintenir et à s’assoir solidement dans les prétoires de la iiie République. Entre temps, ses caractéristiques évoluent sensiblement en raison des nouvelles découvertes cliniques de l’aliénation mentale et de l’apparition de la fi...

  18. Gist of the gas business law amendment. Deregulation in the town gas business field; Gas jigyoho kaisei no yoten. Toshi gas jigyo bun`ya ni okeru kisei kanwa

    Energy Technology Data Exchange (ETDEWEB)

    Tada, A. [Agency of Natural Resources and Energy, Tokyo (Japan)

    1995-07-20

    This paper introduces the summary of the partial amendment in the gas business law (which was enforced in March 1995 upon propositions from the General Energy Investigation Council). The amendment consists mainly of deregulation on business rules for gas supply to large users. The amendment may be summarized as follows: the present billing regulations are deregulated for cases that gas purchasers are large users, permitting in principle the pricing to be agreed upon negotiations between the concerned parties; general gas business operators are allowed to supply gas under certain conditions even outside their supply areas, provided the supply is limited to large users; even any other persons than the general gas business operators can supply gas under certain conditions; persons to start newly a large -scale gas supply business shall be applied with the mandatory portions of the safety regulations that have already been imposed on the general gas business operators; clerical works for the national examination on chief gas engineers will be commissioned to civil organizations; and duplicated application of regulations in the gas utility industry law is eliminated for those operators who are subjected to regulations in the electric utility industry law. 1 fig.

  19. CTHRC1 Acts as a Prognostic Factor and Promotes Invasiveness of Gastrointestinal Stromal Tumors by Activating Wnt/PCP-Rho Signaling

    Directory of Open Access Journals (Sweden)

    Ming-Ze Ma

    2014-03-01

    Full Text Available Gastrointestinal stromal tumors (GISTs are the major gastrointestinal mesenchymal tumors with a variable malignancy ranging from a curable disorder to highly malignant sarcomas. Metastasis and recurrence are the main causes of death in GIST patients. To further explore the mechanism of metastasis and to more accurately estimate the recurrence risk of GISTs after surgery, the clinical significance and functional role of collagen triple helix repeat containing-1 (CTHRC1 in GIST were investigated. We found that CTHRC1 expression was gradually elevated as the risk grade of NIH classification increased, and was closely correlated with disease-free survival and overall survival in 412 GIST patients. In vitro experiments showed that recombinant CTHRC1 protein promoted the migration and invasion capacities of primary GIST cells. A luciferase reporter assay and pull down assay demonstrated that recombinant CTHRC1 protein activated noncanonical Wnt/PCP-Rho signaling but inhibited canonical Wnt signaling. The pro-motility effect of CTHRC1 on GIST cells was reversed by using a Wnt5a neutralizing antibody and inhibitors of Rac1 or ROCK. Taken together, these data indicate that CTHRC1 may serve as a new predictor of recurrence risk and prognosis in post-operative GIST patients and may play an important role in facilitating GIST progression. Furthermore, CTHRC1 promotes GIST cell migration and invasion by activating Wnt/PCP-Rho signaling, suggesting that the CTHRC1-Wnt/PCP-Rho axis may be a new therapeutic target for interventions against GIST invasion and metastasis.

  20. The standard diagnosis, treatment, and follow-up of gastrointestinal stromal tumors based on guidelines.

    Science.gov (United States)

    Nishida, Toshirou; Blay, Jean-Yves; Hirota, Seiichi; Kitagawa, Yuko; Kang, Yoon-Koo

    2016-01-01

    Although gastrointestinal stromal tumors (GISTs) are a rare type of cancer, they are the commonest sarcoma in the gastrointestinal tract. Molecularly targeted therapy, such as imatinib therapy, has revolutionized the treatment of advanced GIST and facilitates scientific research on GIST. Nevertheless, surgery remains a mainstay of treatment to obtain a permanent cure for GIST even in the era of targeted therapy. Many GIST guidelines have been published to guide the diagnosis and treatment of the disease. We review current versions of GIST guidelines published by the National Comprehensive Cancer Network, by the European Society for Medical Oncology, and in Japan. All clinical practice guidelines for GIST include recommendations based on evidence as well as on expert consensus. Most of the content is very similar, as represented by the following examples: GIST is a heterogeneous disease that may have mutations in KIT, PDGFRA, HRAS, NRAS, BRAF, NF1, or the succinate dehydrogenase complex, and these subsets of tumors have several distinctive features. Although there are some minor differences among the guidelines--for example, in the dose of imatinib recommended for exon 9-mutated GIST or the efficacy of antigen retrieval via immunohistochemistry--their common objectives regarding diagnosis and treatment are not only to improve the diagnosis of GIST and the prognosis of patients but also to control medical costs. This review describes the current standard diagnosis, treatment, and follow-up of GISTs based on the recommendations of several guidelines and expert consensus.

  1. GSTT1 copy number gain and ZNF overexpression are predictors of poor response to imatinib in gastrointestinal stromal tumors.

    Directory of Open Access Journals (Sweden)

    Eui Jin Lee

    Full Text Available Oncogenic mutations in gastrointestinal stromal tumors (GISTs predict prognosis and therapeutic responses to imatinib. In wild-type GISTs, the tumor-initiating events are still unknown, and wild-type GISTs are resistant to imatinib therapy. We performed an association study between copy number alterations (CNAs identified from array CGH and gene expression analyses results for four wild-type GISTs and an imatinib-resistant PDGFRA D842V mutant GIST, and compared the results to those obtained from 27 GISTs with KIT mutations. All wild-type GISTs had multiple CNAs, and CNAs in 1p and 22q that harbor the SDHB and GSTT1 genes, respectively, correlated well with expression levels of these genes. mRNA expression levels of all SDH gene subunits were significantly lower (P≤0.041, whereas mRNA expression levels of VEGF (P=0.025, IGF1R (P=0.026, and ZNFs (P<0.05 were significantly higher in GISTs with wild-type/PDGFRA D842V mutations than GISTs with KIT mutations. qRT-PCR validation of the GSTT1 results in this cohort and 11 additional malignant GISTs showed a significant increase in the frequency of GSTT1 CN gain and increased mRNA expression of GSTT1 in wild-type/PDGFRA D842V GISTs than KIT-mutant GISTs (P=0.033. Surprisingly, all four malignant GISTs with KIT exon 11 deletion mutations with primary resistance to imatinib had an increased GSTT1 CN and mRNA expression level of GSTT1. Increased mRNA expression of GSTT1 and ZNF could be predictors of a poor response to imatinib. Our integrative approach reveals that for patients with wild-type (or imatinib-resistant GISTs, attempts to target VEGFRs and IGF1R may be reasonable options.

  2. Distrofia policromática posterior da córnea

    Directory of Open Access Journals (Sweden)

    Letícia Maria Coelho

    2015-06-01

    Full Text Available Os autores descrevem dois casos de distrofia policromática posterior da córnea, uma distrofia pré-Descemet, pouco descrita nas literaturas nacional e mundial, em que se observam pontos policromáticos difusos no estroma posterior da córnea, sem aparente comprometimento da visão.

  3. Update on gastrointestinal stromal tumors for radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Tirumani, Sree Harsha; O' Neill, Alibhe; Jagannathan, Jyothi P. [Dept. of Imaging, Dana-Farber Cancer Institute, Boston (United States); Baheti, Akahay D. [Dept. of Radiology, Tata Memorial Centre, Mumbai (India); Tirumani, Harika [Dept. of Radiology, University of Arkansas for Medical Sciences, Little Rock (United States)

    2017-01-15

    The management of gastrointestinal stromal tumors (GISTs) has evolved significantly in the last two decades due to better understanding of their biologic behavior as well as development of molecular targeted therapies. GISTs with exon 11 mutation respond to imatinib whereas GISTs with exon 9 or succinate dehydrogenase subunit mutations do not. Risk stratification models have enabled stratifying GISTs according to risk of recurrence and choosing patients who may benefit from adjuvant therapy. Assessing response to targeted therapies in GIST using conventional response criteria has several potential pitfalls leading to search for alternate response criteria based on changes in tumor attenuation, volume, metabolic and functional parameters. Surveillance of patients with GIST in the adjuvant setting is important for timely detection of recurrences.

  4. Drugs and lactation

    International Nuclear Information System (INIS)

    Kelssering, G.; Aguiar, L.F.; Ribeiro, R.M.; Souza, A.Z. de

    1988-01-01

    Different kinds of drugs who can be transferred through the mother's milk to the lactant and its effects are showed in this work. A list of them as below: cardiotonics, diuretics, anti-hypertensives, beta-blockings, anti-arrythmics, drugs with gastrintestinal tract action, hormones, antibiotics and chemotherapeutics, citostatic drugs, central nervous system action drugs and anticoagulants drugs. (L.M.J.) [pt

  5. Gene expression in gastrointestinal stromal tumors is distinguished by KIT genotype and anatomic site.

    Science.gov (United States)

    Antonescu, Cristina R; Viale, Agnes; Sarran, Lisa; Tschernyavsky, Sylvia J; Gonen, Mithat; Segal, Neil H; Maki, Robert G; Socci, Nicholas D; DeMatteo, Ronald P; Besmer, Peter

    2004-05-15

    Gastrointestinal stromal tumors (GISTs) are specific KIT expressing and KIT-signaling driven mesenchymal tumors of the human digestive tract, many of which have KIT-activating mutations. Previous studies have found a relatively homogeneous gene expression profile in GIST, as compared with other histological types of sarcomas. Transcriptional heterogeneity within clinically or molecularly defined subsets of GISTs has not been previously reported. We tested the hypothesis that the gene expression profile in GISTs might be related to KIT genotype and possibly to other clinicopathological factors. An HG-U133A Affymetrix chip (22,000 genes) platform was used to determine the variability of gene expression in 28 KIT-expressing GIST samples from 24 patients. A control group of six intra-abdominal leiomyosarcomas was also included for comparison. Statistical analyses (t tests) were performed to identify discriminatory gene lists among various GIST subgroups. The levels of expression of various GIST subsets were also linked to a modified version of the growth factor/KIT signaling pathway to analyze differences at various steps in signal transduction. Genes involved in KIT signaling were differentially expressed among wild-type and mutant GISTs. High gene expression of potential drug targets, such as VEGF, MCSF, and BCL2 in the wild-type group, and Mesothelin in exon 9 GISTs were found. There was a striking difference in gene expression between stomach and small bowel GISTs. This finding was validated in four separate tumors, two gastric and two intestinal, from a patient with familial GIST with a germ-line KIT W557R substitution. GISTs have heterogeneous gene expression depending on KIT genotype and tumor location, which is seen at both the genomic level and the KIT signaling pathway in particular. These findings may explain their variable clinical behavior and response to therapy.

  6. Esophageal Gastrointestinal Stromal Tumors Presenting as Mediastinal Mass

    Directory of Open Access Journals (Sweden)

    M. Kafeel

    2013-11-01

    Full Text Available Gastrointestinal stromal tumors (GISTs are the most common mesenchymal tumors of the gastrointestinal tract and are predominant in the stomach and intestine but rare in the esophagus. Here, we report a case of esophageal GIST which presented as a mediastinal mass on chest X-ray and dyspnea. The case was initially diagnosed as leiomyosarcoma, which could create a diagnostic dilemma. Therefore, recognizing this uncommon presentation as a mediastinal mass with esophageal GIST is important in the differential diagnosis.

  7. Rare case of gastrointestinal stromal tumor of the anal canal

    Directory of Open Access Journals (Sweden)

    Madhu Kumar

    2013-01-01

    Full Text Available Gastrointestinal stromal tumor (GIST is a rare mesenchymal neoplasm of the gastrointestinal tract. GIST of anal canal is very rare representing only 3% of all anorectal mesenchymal tumors. We report an extremely rare case of GIST of the anal canal in 60-years-old man with history of irregular bowel habits with dark colored stool mixed with blood and constipation from 6 month. Diagnosis was made on the basis of histomorphological and immunohistochemical examination.

  8. Gastrointestinal stromal tumors

    International Nuclear Information System (INIS)

    Sufliarsky, J.

    2011-01-01

    Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the digestive tract. Better understanding of the molecular characteristics of GISTs led to the clinical development of imatinib for treating patients with this disease. New immuno markers and mechanisms of primary and secondary resistance were discovered. Adjuvant imatinib in intermediate or high risk GIST has improved the recurrence-free survival. Sunitinib in patients with intolerance or progression on imatinib demonstrated significant improvements in progression-free and overall survival versus placebo. Second-generation tyrosine kinase inhibitors, such as sorafenib, dasatinib, and nilotinib, have shown activity in patients with imatinib- and sunitinib-resistant GIST. (author)

  9. Radiotherapy in the treament of gastrointestinal stromal tumors

    Directory of Open Access Journals (Sweden)

    Rebecca C. Heintzelman

    2011-10-01

    Full Text Available Gastrointestinal stromal tumors (GIST are uncommon mesenchymal tumors of the gastrointestinal tract. Up to one-third of GISTs are malignant with a high rate of metastasis. Surgical resection is the mainstay of care for patients with resectable disease. Imatinib mesylate, a selective tyrosine kinase inhibitor, is the current standard of care for GISTs that cannot be completely resected or in cases of metastatic GIST. Although often overlooked, radiation therapy is a viable option for select patients with GIST. We report the case of a patient with unresectable GIST who was treated with local radiotherapy and achieved longterm response. We also present a review of the literature regarding the use of radiotherapy in the treatment of GIST. GIST has been shown to be a radiosensitive tumor. Radiotherapy can offer long-term local control and should be considered in the adjuvant or palliative setting. The role of radiotherapy delivered concurrently with imatinib in the treatment of GIST may warrant further investigation.

  10. Ghrelin and gastrointestinal stromal tumors.

    Science.gov (United States)

    Zhu, Chang-Zhen; Liu, Dong; Kang, Wei-Ming; Yu, Jian-Chun; Ma, Zhi-Qiang; Ye, Xin; Li, Kang

    2017-03-14

    Ghrelin, as a kind of multifunctional protein polypeptide, is mainly produced in the fundus of the stomach and can promote occurrence and development of many tumors, including gastrointestinal tumors, which has been proved by the relevant researches. Most gastrointestinal stromal tumors (GISTs, about 80%), as the most common mesenchymal tumor, also develop in the fundus. Scientific research has confirmed that ghrelin, its receptors and mRNA respectively can be found in GISTs, which demonstrated the existence of a ghrelin autocrine/paracrine loop in GIST tissues. However, no reports to date have specified the mechanism whether ghrelin can promote the occurrence and development of GISTs. Studies of pulmonary artery endothelial cells in a low-oxygen environment and cardiac muscle cells in an ischemic environment have shown that ghrelin can activate the phosphatidylinositol 3-kinase/AKT/mammalian target of rapamycin (PI3K/AKT/mTOR) signaling pathway. Moreover, some studies of GISTs have confirmed that activation of the PI3K/AKT/mTOR pathway can indeed promote the growth and progression of GISTs. Whether ghrelin is involved in the development or progression of GISTs through certain pathways remains unknown. Can we find a new target for the treatment of GISTs? This review explores and summaries the relationship among ghrelin, the PI3K/AKT/mTOR pathway and the development of GISTs.

  11. Synchronous Epithelioid Stromal Tumour and Lipoma in the Stomach

    Directory of Open Access Journals (Sweden)

    Nabeel Al-Brahim

    2003-01-01

    Full Text Available An 82-year-old man presented with upper gastrointestinal bleeding. A polypoid lesion of the distal stomach with focal ulceration was seen at endoscopy. This was treated by a partial gastrectomy. The resected stomach contained two separate tumours near the pylorus: a gastrointestinal stromal tumour (GIST and an adjacent lipoma. The literature includes case reports of synchronously occurring GIST and adenocarcinoma, GIST and mucosa-associated lymphoid tissue lymphoma and GIST and carcinoid tumour. Herein is the first case report of two distinct mesenchymal tumors coexisting in the stomach.

  12. Efficacy of a web-based intelligent tutoring system for communicating genetic risk of breast cancer: a fuzzy-trace theory approach.

    Science.gov (United States)

    Wolfe, Christopher R; Reyna, Valerie F; Widmer, Colin L; Cedillos, Elizabeth M; Fisher, Christopher R; Brust-Renck, Priscila G; Weil, Audrey M

    2015-01-01

    . Many healthy women consider genetic testing for breast cancer risk, yet BRCA testing issues are complex. . To determine whether an intelligent tutor, BRCA Gist, grounded in fuzzy-trace theory (FTT), increases gist comprehension and knowledge about genetic testing for breast cancer risk, improving decision making. . In 2 experiments, 410 healthy undergraduate women were randomly assigned to 1 of 3 groups: an online module using a Web-based tutoring system (BRCA Gist) that uses artificial intelligence technology, a second group read highly similar content from the National Cancer Institute (NCI) Web site, and a third that completed an unrelated tutorial. . BRCA Gist applied FTT and was designed to help participants develop gist comprehension of topics relevant to decisions about BRCA genetic testing, including how breast cancer spreads, inherited genetic mutations, and base rates. . We measured content knowledge, gist comprehension of decision-relevant information, interest in testing, and genetic risk and testing judgments. . Control knowledge scores ranged from 54% to 56%, NCI improved significantly to 65% and 70%, and BRCA Gist improved significantly more to 75% and 77%, P tutors, such as BRCA Gist, are scalable, cost-effective ways of helping people understand complex issues, improving decision making. © The Author(s) 2014.

  13. Enhancing inferential abilities in adolescence: new hope for students in poverty.

    Science.gov (United States)

    Gamino, Jacquelyn F; Motes, Michael M; Riddle, Russell; Lyon, G Reid; Spence, Jeffrey S; Chapman, Sandra B

    2014-01-01

    The ability to extrapolate essential gist through the analysis and synthesis of information, prediction of potential outcomes, abstraction of ideas, and integration of relationships with world knowledge is critical for higher-order learning. The present study investigated the efficacy of cognitive training to elicit improvements in gist reasoning and fact recall ability in 556 public middle school students (grades seven and eight), vs. a sample of 357 middle school students who served as a comparison group, to determine if changes in gist reasoning and fact recall were demonstrated without cognitive training. The results showed that, in general, cognitive training increased gist reasoning and fact recall abilities in students from families in poverty as well as students from families living above poverty. However, the magnitude of gains in gist reasoning varied as a function of gender and grade level. Our primary findings were that seventh and eighth grade girls and eighth grade boys showed significant increases in gist reasoning after training regardless of socioeconomic status (SES). There were no significant increases in gist reasoning or fact recall ability for the 357 middle school students who served as a comparison group. We postulate that cognitive training in middle school is efficacious for improving gist reasoning ability and fact recall in students from all socioeconomic levels.

  14. Enhancing Inferential Abilities in Adolescence: New Hope for Students in Poverty

    Directory of Open Access Journals (Sweden)

    Jacquelyn F Gamino

    2014-12-01

    Full Text Available The ability to extrapolate essential gist through the analysis and synthesis of information, prediction of potential outcomes, abstraction of ideas, and integration of relationships with world knowledge is critical for higher-order learning. The present study investigated the efficacy of cognitive training to elicit improvements in gist-reasoning and fact recall ability in 556 public middle-school students (grades seven and eight, versus a sample of 357 middle school students who served as a comparison group, to determine if changes in gist-reasoning and fact recall were demonstrated without cognitive training. The results showed that, in general, cognitive training increased gist-reasoning and fact recall abilities in students from families in poverty as well as students from families living above poverty. However, the magnitude of gains in gist-reasoning varied as a function of gender and grade-level. Our primary findings were that seventh and eighth grade girls and eighth grade boys showed significant increases in gist-reasoning after training regardless of socioeconomic status. There were no significant increases in gist-reasoning or fact recall ability for the 357 middle school students who served in the comparison group. We postulate that cognitive training in middle school is efficacious for improving gist-reasoning ability and fact recall in students from all socioeconomic levels.

  15. Kasumit kasvatanud Eesti Energia hinnatõusutaotlusest ei tagane / Kaur Paves

    Index Scriptorium Estoniae

    Paves, Kaur

    2011-01-01

    Ettevõtte puhaskasumist, osaluse müügist Jordaania tütarettevõttes, elektri müügist avatud turgudel, elektrihinna tõusu taotlemisest ja uuest kliendiinfosüsteemist. Skeem: Energiahiid teenis hästi

  16. Large gastrointestinal stromal tumor and advanced adenocarcinoma in the rectum coexistent with an incidental prostate carcinoma: A case report

    Directory of Open Access Journals (Sweden)

    Toshiaki Suzuki

    2014-01-01

    CONCLUSION: Radical surgery with perioperative adjuvant chemotherapy using tyrosine kinase inhibitors is the choice for treatment of large GISTs with a malignant potential. Our report suggests that aggressive surgical approach would be feasible, when a secondary tumor is present near the GIST.

  17. Gastrointestinal Stromal Tumor of the Esophagus: Report of a Case

    OpenAIRE

    Mehmet Erol

    2014-01-01

    Gastrointestinal stromal tumors are rare neoplasms to be thought to arise from mesenchymal cells of the gastrointestinal tract. Gastrointestinal stromal tumors (GIST) of the esophagus are well documented but are very much rarer than gastrointestinal stromal tumors of the stomach and small bowel. We describe a case of GIST of the esophagus that was resected with wide surgical resection.

  18. Effective vaccine communication during the disneyland measles outbreak.

    Science.gov (United States)

    Broniatowski, David A; Hilyard, Karen M; Dredze, Mark

    2016-06-14

    Vaccine refusal rates have increased in recent years, highlighting the need for effective risk communication, especially over social media. Fuzzy-trace theory predicts that individuals encode bottom-line meaning ("gist") and statistical information ("verbatim") in parallel and those articles expressing a clear gist will be most compelling. We coded news articles (n=4581) collected during the 2014-2015 Disneyland measles for content including statistics, stories, or bottom-line gists regarding vaccines and vaccine-preventable illnesses. We measured the extent to which articles were compelling by how frequently they were shared on Facebook. The most widely shared articles expressed bottom-line gists, although articles containing statistics were also more likely to be shared than articles lacking statistics. Stories had limited impact on Facebook shares. Results support Fuzzy Trace Theory's predictions regarding the distinct yet parallel impact of categorical gist and statistical verbatim information on public health communication. Copyright © 2016 Elsevier Ltd. All rights reserved.

  19. Bariatric surgery and incidental gastrointestinal stromal tumors - a single-center study: VSJ Competition, 1st place.

    Science.gov (United States)

    Walędziak, Maciej; Różańska-Walędziak, Anna; Kowalewski, Piotr K; Janik, Michał R; Brągoszewski, Jakub; Paśnik, Krzysztof

    2017-09-01

    Gastrointestinal stromal tumors (GISTs), originating from Cajal cells, are most commonly located in the stomach; therefore they can be found in the specimens excised during bariatric operations. The global prevalence of GISTs is about 130 cases per million population. Morbidity differs depending on geographical latitude. Although surgery is the treatment of choice for GISTs, 40-50% of patients after radical surgical treatment will have a relapse or metastases. To analyze the incidence of GISTs in patients undergoing bariatric surgery and to verify whether an operation performed according to the bariatric protocol is oncologically radical in case of GIST. A single-center retrospective study. The study group comprised 1252 obese patients qualified for bariatric procedures, with no upper gastrointestinal tract neoplasms found during preoperative diagnostic examinations. In case of suspicious macroscopic pathologies (n = 81) present during the operation, tissue specimens underwent histopathological examination with further investigation performed if GISTs were found, including tumor size and localization, mitotic index and immunohistochemical analysis. Gastrointestinal stromal tumors were found in 16 cases, and benign tumors of various histological origin in 33 cases. All cases of GIST found came from stomach specimens, 7 from the gastric corpus vs. 9 from the fundus. Fourteen GISTs were found during laparoscopic sleeve gastrectomies (LSGs) vs. 2 during laparoscopic Roux-en-Y gastric bypasses (LRYGBs). In case of incidental findings of GISTs during bariatric surgery, tumor resection with negative margins of incision may be considered as complete oncological treatment if there was very low/low risk stratification of GIST's recurrence after surgery.

  20. O modelo de pseudogestação em camundongos para o estudo 'in situ' das celulas Natural Killer uterinas

    OpenAIRE

    Juares Ednaldo Romero Bianco

    2006-01-01

    Resumo: Durante o período peri-implantacional na gestação de humanos e roedores, ocorre no estroma da mucosa uterina um conjunto de fenômenos que envolvem modificações dos componentes celulares e da matriz extracelular. Este conjunto de modificações é conhecido como decidualização ou reação decidual. Concomitante a este processo ocorre a migração de leucócitos provenientes de órgão hematopoéticos para este estroma. Dentre estes leucócitos predominam as subpopulações de linfócitos denominados ...

  1. Tumor de reto e cárdia sincrônicos: relato de caso e revisão da literatura Rectum and cardia cynchronous tumor: case report and literature review

    Directory of Open Access Journals (Sweden)

    Robson Luis Silveira Jara

    2007-03-01

    Full Text Available Os autores relatam um caso raro de um paciente de 77 anos, que desenvolveu dois tumores sincrônicos do trato gastrintestinal, localizados em topografia de reto e cárdia. Feito o diagnóstico de ambos simultaneamente. Foi submetido à cirurgia em dois tempos e evoluiu bem, realizando a reconstrução do trato gastrintestinal três meses após a primeira intervenção. Não encontramos na literatura nenhum outro relato desta combinação de tumores.We discuss a 77-year-old man who developed two cancers: adenocarcinoma of the stomach and adenocarcinoma of the rectum. He was submitted at the surgery developed for two interventions and evolved aright. To the best of our knowledge, no other patient with the combination of these two cancers has been reported in the literature.

  2. Distrofia corneal de Schnyder

    Directory of Open Access Journals (Sweden)

    Michel Guerra Almaguer

    Full Text Available La principal entidad hereditaria con depósitos de lípidos en el estroma corneal es la distrofia cristalina central, conocida como distrofia de Schnyder, quien la describió en Suiza en 1927. Se caracteriza por depósitos blanco-amarillentos en el estroma corneal central y superficial. Se presenta un paciente de 28 años, del sexo masculino y piel negra, con antecedente de salud anterior. Acudió a consulta y refirió una disminución de la visión y cambio de coloración progresiva de ambos ojos, de años de evolución. En la exploración oftalmológica de ambos ojos se apreciaron lesiones blanquecinas anulares a nivel del estroma corneal, con ligera turbidez corneal central. Los estudios refractivos realizados constataron un astigmatismo hipermetrópico simple. El resto del examen oftalmológico fue negativo. Para el diagnóstico de certeza se empleó el microscopio confocal. Se concluye que el caso presenta una distrofia corneal estromal de tipo cristalina, de Schnyder.

  3. Evaluation of quatitative scintigraphic method in diagnosis of esophagic involvement of Progressive Systemic Sclerosis

    International Nuclear Information System (INIS)

    Von Muehlen, C.A.

    1985-01-01

    Twenty patients with Progressive Systemic Sclerosis are studied by scintigraphic methodology. The esophageal transit method is used for liquid and solid meals. The results are compared with the ones of a control group, without or not gastrintestinal problems but without autoimmune diasese. 99 sup(m)Tc-sulfurcolloid is used as labelling compound. The studies were done in supine and orthostatical position. (M.A.C.) [pt

  4. Síndrome de Churg-Strauss Churg-Strauss syndrome

    Directory of Open Access Journals (Sweden)

    Juliana Monteiro de Barros

    2005-07-01

    Full Text Available A síndrome de Churg-Strauss caracteriza-se por asma, eosinofilia e graus variados de vasculite sistêmica. As formas mais graves com acometimento cardíaco, gastrintestinal, sistema nervoso central e renal requerem ciclofosfamida para seu tratamento.Churg-Strauss syndrome is characterized by asthma, eosinophilia and various degrees of systemic vasculitis. The most severe forms of the disease, presenting cardiac, gastrointestinal, central nervous system and renal involvement, require cyclophosphamide therapy.

  5. The Difference between Right and Wrong: Accuracy of Older and Younger Adults’ Story Recall

    Science.gov (United States)

    Davis, Danielle K.; Alea, Nicole; Bluck, Susan

    2015-01-01

    Sharing stories is an important social activity in everyday life. This study used fine-grained content analysis to investigate the accuracy of recall of two central story elements: the gist and detail of socially-relevant stories. Younger (M age = 28.06) and older (M age = 75.03) American men and women (N = 63) recalled fictional stories that were coded for (i) accuracy of overall gist and specific gist categories and (ii) accuracy of overall detail and specific detail categories. Findings showed no age group differences in accuracy of overall gist or detail, but differences emerged for specific categories. Older adults more accurately recalled the gist of when the event occurred whereas younger adults more accurately recalled the gist of why the event occurred. These differences were related to episodic memory ability and education. For accuracy in recalling details, there were some age differences, but gender differences were more robust. Overall, women remembered details of these social stories more accurately than men, particularly time and perceptual details. Women were also more likely to accurately remember the gist of when the event occurred. The discussion focuses on how accurate recall of socially-relevant stories is not clearly age-dependent but is related to person characteristics such as gender and episodic memory ability/education. PMID:26404344

  6. Using molecular diagnostic testing to personalize the treatment of patients with gastrointestinal stromal tumors.

    Science.gov (United States)

    Bannon, Amber E; Klug, Lillian R; Corless, Christopher L; Heinrich, Michael C

    2017-05-01

    The diagnosis and treatment of gastrointestinal stromal tumor (GIST) has emerged as a paradigm for modern cancer treatment ('precision medicine'), as it highlights the importance of matching molecular defects with specific therapies. Over the past two decades, the molecular classification and diagnostic work up of GIST has been radically transformed, accompanied by the development of molecular therapies for specific subgroups of GIST. This review summarizes the developments in the field of molecular diagnosis of GIST, particularly as they relate to optimizing medical therapy. Areas covered: Based on an extensive literature search of the molecular and clinical aspects of GIST, the authors review the most important developments in this field with an emphasis on the differential diagnosis of GIST including mutation testing, therapeutic implications of each molecular subtype, and emerging technologies relevant to the field. Expert commentary: The use of molecular diagnostics to classify GIST has been shown to be successful in optimizing patient treatment, but these methods remain under-utilized. In order to facilitate efficient and comprehensive molecular testing, the authors have developed a decision tree to aid clinicians.

  7. The Difference between Right and Wrong: Accuracy of Older and Younger Adults' Story Recall.

    Science.gov (United States)

    Davis, Danielle K; Alea, Nicole; Bluck, Susan

    2015-09-02

    Sharing stories is an important social activity in everyday life. This study used fine-grained content analysis to investigate the accuracy of recall of two central story elements: the gist and detail of socially-relevant stories. Younger (M age = 28.06) and older (M age = 75.03) American men and women (N = 63) recalled fictional stories that were coded for (i) accuracy of overall gist and specific gist categories and (ii) accuracy of overall detail and specific detail categories. Findings showed no age group differences in accuracy of overall gist or detail, but differences emerged for specific categories. Older adults more accurately recalled the gist of when the event occurred whereas younger adults more accurately recalled the gist of why the event occurred. These differences were related to episodic memory ability and education. For accuracy in recalling details, there were some age differences, but gender differences were more robust. Overall, women remembered details of these social stories more accurately than men, particularly time and perceptual details. Women were also more likely to accurately remember the gist of when the event occurred. The discussion focuses on how accurate recall of socially-relevant stories is not clearly age-dependent but is related to person characteristics such as gender and episodic memory ability/education.

  8. Small Submucosal Tumors of the Stomach: Differentiation of Gastric Schwannoma from Gastrointestinal Stromal Tumor with CT

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Jin Wook; Choi, Dong Gil; Kim, Kyoung Mee; Sohn, Tae Sung; Lee, Jun Haeng; Kim, Hee Jung; Lee, Soon Jin [Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2012-07-15

    To identify the CT features that help differentiate gastric schwannomas (GS) from small (5 cm or smaller) gastrointestinal stromal tumors (GIST) and to assess the growth rates of both tumors. We included 16 small GSs and 56 GISTs located in the stomach. We evaluated the CT features including size, contour, surface pattern, margins, growth pattern, pattern and degree of contrast enhancement, and the presence of intralesional low attenuation area, hemorrhage, calcification, surface dimpling, fistula, perilesional lymph nodes (LNs), invasion to other organs, metastasis, ascites, and peritoneal seeding. We also estimated the tumor volume doubling time. Compared with GISTs, GSs more frequently demonstrated a homogeneous enhancement pattern, exophytic or mixed growth pattern, and the presence of perilesional LNs (each p < 0.05). The intralesional low attenuation area was more common in GISTs than GSs (p < 0.05). Multivariate analyses indicated that a homogeneous enhancement pattern, exophytic or mixed growth pattern, and the presence of perilesional LNs were statistically significant (p < 0.05). Tumor volume doubling times for GSs (mean, 1685.4 days) were significantly longer than that of GISTs (mean, 377.6 days) (p = 0.004). Although small GSs and GISTs show similar imaging findings, GSs more frequently show an exophytic or mixed growth pattern, homogeneous enhancement pattern, perilesional LNs and grow slower than GISTs.

  9. Small Submucosal Tumors of the Stomach: Differentiation of Gastric Schwannoma from Gastrointestinal Stromal Tumor with CT

    International Nuclear Information System (INIS)

    Choi, Jin Wook; Choi, Dong Gil; Kim, Kyoung Mee; Sohn, Tae Sung; Lee, Jun Haeng; Kim, Hee Jung; Lee, Soon Jin

    2012-01-01

    To identify the CT features that help differentiate gastric schwannomas (GS) from small (5 cm or smaller) gastrointestinal stromal tumors (GIST) and to assess the growth rates of both tumors. We included 16 small GSs and 56 GISTs located in the stomach. We evaluated the CT features including size, contour, surface pattern, margins, growth pattern, pattern and degree of contrast enhancement, and the presence of intralesional low attenuation area, hemorrhage, calcification, surface dimpling, fistula, perilesional lymph nodes (LNs), invasion to other organs, metastasis, ascites, and peritoneal seeding. We also estimated the tumor volume doubling time. Compared with GISTs, GSs more frequently demonstrated a homogeneous enhancement pattern, exophytic or mixed growth pattern, and the presence of perilesional LNs (each p < 0.05). The intralesional low attenuation area was more common in GISTs than GSs (p < 0.05). Multivariate analyses indicated that a homogeneous enhancement pattern, exophytic or mixed growth pattern, and the presence of perilesional LNs were statistically significant (p < 0.05). Tumor volume doubling times for GSs (mean, 1685.4 days) were significantly longer than that of GISTs (mean, 377.6 days) (p = 0.004). Although small GSs and GISTs show similar imaging findings, GSs more frequently show an exophytic or mixed growth pattern, homogeneous enhancement pattern, perilesional LNs and grow slower than GISTs.

  10. The Difference between Right and Wrong: Accuracy of Older and Younger Adults’ Story Recall

    Directory of Open Access Journals (Sweden)

    Danielle K. Davis

    2015-09-01

    Full Text Available Sharing stories is an important social activity in everyday life. This study used fine-grained content analysis to investigate the accuracy of recall of two central story elements: the gist and detail of socially-relevant stories. Younger (M age = 28.06 and older (M age = 75.03 American men and women (N = 63 recalled fictional stories that were coded for (i accuracy of overall gist and specific gist categories and (ii accuracy of overall detail and specific detail categories. Findings showed no age group differences in accuracy of overall gist or detail, but differences emerged for specific categories. Older adults more accurately recalled the gist of when the event occurred whereas younger adults more accurately recalled the gist of why the event occurred. These differences were related to episodic memory ability and education. For accuracy in recalling details, there were some age differences, but gender differences were more robust. Overall, women remembered details of these social stories more accurately than men, particularly time and perceptual details. Women were also more likely to accurately remember the gist of when the event occurred. The discussion focuses on how accurate recall of socially-relevant stories is not clearly age-dependent but is related to person characteristics such as gender and episodic memory ability/education.

  11. Giant gastrointestinal stromal tumour of rare sarcomatoid epithelioid subtype: Case study and literature review

    Science.gov (United States)

    Lech, Gustaw; Korcz, Wojciech; Kowalczyk, Emilia; Guzel, Tomasz; Radoch, Marcin; Krasnodębski, Ireneusz Wojciech

    2015-01-01

    Gastrointestinal stromal tumours (GISTs) are the most common mesenchymal tumours of the gastrointestinal tract, but they represent less than 3% of all gastrointestinal tract malignancies. This is a detailed case study of a 52-year-old male patient treated for very uncommon histological subtype of gastric GIST with atypical clinical presentation, asymptomatic progress and late diagnosis. The resected tumour, giant in diameters, was confirmed to represent the most rare histopathologic subtype of GISTs - sarcomatoid epithelioid GIST. We report this case and review the literature with a special focus on pathomorphological evaluation, biological aggressiveness and prognostic factors. To our knowledge this is the first report of giant GIST of very uncommon sarcomatoid epithelioid subtype. It is concluded that clinicians should pay attention to the fact that initial diagnosis may be delayed due to mildly asymptomatic and non-specific clinical presentation. Asymptomatic tumours diagnosed at a late stage, which is often the case, can be large on presentation. Prognosis for patients diagnosed with GIST depend on tumour size, mitotic rate, histopathologic subtype and tumour location. That is why early diagnosis and R0 resection, which is usually feasible and safe even in giant gastric sarcomatoid epithelioid subtype of GISTs, are the key factors for further treatment and good prognosis. PMID:25805949

  12. Computed tomography features and predictive findings of ruptured gastrointestinal stromal tumours

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jin Sil; Kim, Hyun Jin; Park, Seong Ho; Lee, Jong Seok; Kim, Ah Young; Ha, Hyun Kwon [University of Ulsan College of Medicine, Department of Radiology and Research Institute of Radiology, Songpa-Gu, Seoul (Korea, Republic of)

    2017-06-15

    To evaluate the CT features of ruptured GISTs and factors that might be predictive of rupture through comparison with CTs taken prior to rupture and CTs of non-ruptured GIST. Forty-nine patients with ruptured GIST and forty-nine patients with non-ruptured GIST matched by age, gender and location were included. Clinical data including pharmacotherapy were reviewed. The imaging features were analyzed. Prior CT obtained before rupture were evaluated. The most common location of ruptured GIST was small bowel with mean size of 12.1 cm. Ruptured GIST commonly showed wall defects, >40 % eccentric necrosis, lobulated shaped, air density in mass, pneumoperitoneum, peritonitis, hemoperitoneum and ascites (p < 0.001-0.030). Twenty-seven of 30 patients with follow up imaging received targeted therapy. During follow-up, thickness of the tumour wall decreased. Increase in size and progression of necrosis were common during targeted therapy (p = 0.017). Newly developed ascites, peritonitis and hemoperitoneum was more common (p < 0.001-0.036). Ruptured GISTs commonly demonstrate large size, >40 % eccentric necrosis, wall defects and lobulated shape. The progression of necrosis with increase in size and decreased wall thickness during targeted therapy may increase the risk of rupture. Rupture should be considered when newly developed peritonitis, hemoperitoneum, or ascites are noted during the follow-up. (orig.)

  13. Surgical Pathology of Gastrointestinal Stromal Tumors: Practical Implications of Morphologic and Molecular Heterogeneity for Precision Medicine.

    Science.gov (United States)

    Charville, Gregory W; Longacre, Teri A

    2017-11-01

    Gastrointestinal stromal tumor (GIST), the most common mesenchymal neoplasm of the gastrointestinal tract, exhibits diverse histologic and clinical manifestations. With its putative origin in the gastrointestinal pacemaker cell of Cajal, GIST can arise in association with any portion of the tubular gastrointestinal tract. Morphologically, GISTs are classified as spindled or epithelioid, though each of these subtypes encompasses a broad spectrum of microscopic appearances, many of which mimic other histologic entities. Despite this morphologic ambiguity, the diagnosis of GIST is aided in many cases by immunohistochemical detection of KIT (CD117) or DOG1 expression. The natural history of GIST ranges from that of a tumor cured by surgical resection to that of a locally advanced or even widely metastatic, and ultimately fatal, disease. This clinicopathologic heterogeneity is paralleled by an underlying molecular diversity: the majority of GISTs are associated with spontaneous activating mutations in KIT, PDGFRA, or BRAF, while additional subsets are driven by genetic lesions-often inherited-of NF1 or components of the succinate dehydrogenase enzymatic complex. Specific gene mutations correlate with particular anatomic or morphologic characteristics and, in turn, with distinct clinical behaviors. Therefore, prognostication and treatment are increasingly dictated not only by morphologic clues, but also by accompanying molecular genetic features. In this review, we provide a comprehensive description of the heterogenous molecular underpinnings of GIST, including implications for the practicing pathologist with regard to morphologic identification, immunohistochemical diagnosis, and clinical management.

  14. SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

    International Nuclear Information System (INIS)

    Italiano, Antoine; Chen, Chun-Liang; Sung, Yun-Shao; Singer, Samuel; DeMatteo, Ronald P; LaQuaglia, Michael P; Besmer, Peter; Socci, Nicholas; Antonescu, Cristina R

    2012-01-01

    A subset of KIT/PDGFRA wild-type gastrointestinal stromal tumors (WT GIST) have been associated with alteration of the succinate dehydrogenase (SDH) complex II function. A recent report identified four non-syndromic, KIT/PDGFRA WT GIST harboring compound heterozygous or homozygous mutations in SDHA encoding the main subunit of the SDH complex II. Next generation sequencing was applied on five pediatric and one young adult WT GIST, by whole exome capture and SOLiD 3-plus system sequencing. The putative mutations were first confirmed by Sanger sequencing and then screened on a larger panel of 11 pediatric and young adult WT GIST, including 5 in the context of Carney triad. A germline p.Arg31X nonsense SDHA mutation was identified in one of the six cases tested by SOLiD platform. An additional p.D38V missense mutation in SDHA exon 2 was identified by Sanger sequencing in the extended KIT/PDGFRA WT GIST patients cohort. Western blotting showed loss of SDHA expression in the two cases harboring SDHA mutations, while expression being retained in the other WT GIST tumors. Results were further confirmed by immunohistochemistry for both SDHA and SDHB, which showed a concurrent loss of expression of both proteins in SDHA-mutant lesions, while the remaining WT tumors showed only loss of SDHB expression. Germline and/or somatic aberrations of SDHA occur in a small subset of KIT/PDGFRA WT GISTs, outside the Carney’s triad and are associated with loss of both SDHA and SDHB protein expression. Mutations of the SDH complex II are more particularly associated with KIT/PDGFRA WT GIST occurring in young adults. Although pediatric GIST consistently display alterations of SDHB protein expression, further molecular studies are needed to identify the crucial genes involved in their tumorigenesis

  15. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature.

    Science.gov (United States)

    Prakash, Sonam; Sarran, Lisa; Socci, Nicholas; DeMatteo, Ronald P; Eisenstat, Jonathan; Greco, Alba M; Maki, Robert G; Wexler, Leonard H; LaQuaglia, Michael P; Besmer, Peter; Antonescu, Cristina R

    2005-04-01

    Gastrointestinal stromal tumors (GISTs) are mesenchymal tumors of the intestinal tract that typically occur in adults over the age of 40 years. GISTs in younger patients are rare and not well characterized. The objective was to define the characteristics of GISTs in children and young adults (<30 years old). Clinicopathologic and molecular features, including KIT/PDGFRA genotype, in GISTs from 5 children and 10 young adults were analyzed. Gene expression analysis was performed on 5 gastric tumor samples from 2 children, 2 gastric tumors from young adults, and 10 gastric GISTs from older adults using an U133A Affymetrix platform (22,000 genes). All five pediatric GISTs occurred in girls, involved the stomach as multiple nodules, showed predominantly an epithelioid morphology, often involved lymph nodes, and lacked KIT or PDGFRA mutations. Although all five patients developed recurrence (four in the liver, three in the peritoneum, and two in both sites), four are still alive with disease. Of the 10 GISTs in young adults, half occurred in the small bowel and had spindle cell morphology, and one case had lymph node metastasis. KIT mutations were identified in seven cases, four in exon 11 and three in exon 9. Seven patients developed recurrence, and at last follow-up two patients had died of disease. Gene expression analysis showed high expression of PHKA1, FZD2, NLGN4, IGF1R, and ANK3 in the pediatric and young adult versus older adult cases. GISTs that occur in children are a separate clinicopathologic and molecular subset with predilection for girls, multifocal gastric tumors, and wild-type KIT/PDGFRA genotype. In contrast, GISTs in young adults are a more heterogeneous group, including cases that resemble either the pediatric or the older adult-type tumors. The distinct gene expression profile suggests avenues for investigation of pathogenesis and potential therapeutic strategies.

  16. Tenascin and fibronectin in pleomorphic adenoma of the salivary gland Tenascina e fibronectina em adenoma pleomórfico de glândula salivar

    Directory of Open Access Journals (Sweden)

    Patrícia Meira Bento

    2006-06-01

    Full Text Available OBJECTIVES: To analyze the expression and distribution pattern of extracellular matrix components in pleomorphic adenomas of the major and minor salivary glands and to compare the morphological findings of these tumors with the immunohistochemical expression, considering the different types of stroma predominating in each case. METHODS AND RESULTS: The expression of tenascin (TN and fibronectin (FN was analyzed in 23 cases of pleomorphic adenomas, 11 major and 12 minor salivary gland tumors, by the streptavidin-biotin method using anti-tenascin and anti-fibronectin antibodies. In addition, the immunohistochemical results were correlated with the morphological findings of the lesions. All cases analyzed were immunoreactive for the antibodies used. Fibronectin showed strong labeling in fibrous and chondroid stroma, while labeling was weak in hyaline and myxoid stroma. Tenascin expression was more intense in fibrous and chondroid stroma and moderate in hyaline and myxoid stroma. CONCLUSIONS: No difference in the expression of these proteins was observed between major and minor salivary gland tumors.OBJETIVO: Analisar a expressão e o padrão de distribuição de componentes da matriz extracelular em adenomas pleomórficos de glândula salivar maior e menor e comparar os achados morfológicos destes tumores com a expressão imuno-histoquímica considerando os diferentes tipos de estromas presentes em cada caso. MÉTODOS E RESULTADOS: A expressão da tenascina (TN e fibronectina (FN foi analisada em 23 casos de adenomas pleomórficos, sendo 11 tumores em glândula salivar maior e 12 em glândula salivar menor, utilizando-se o método da estreptoavidina-biotina para os anticorpos anti-tenascina e anti-fibronectina. Os resultados imuno-histoquimicos foram correlacionados com os achados morfológicos das lesões. Todos os casos foram imunorreativos para a fibronectina mostrando forte expressão nos estromas fibrosos e condróides, embora fraca marca

  17. Image Analysis of Endosocopic Ultrasonography in Submucosal Tumor Using Fuzzy Inference

    Directory of Open Access Journals (Sweden)

    Kwang Baek Kim

    2013-01-01

    Full Text Available Endoscopists usually make a diagnosis in the submucosal tumor depending on the subjective evaluation about general images obtained by endoscopic ultrasonography. In this paper, we propose a method to extract areas of gastrointestinal stromal tumor (GIST and lipoma automatically from the ultrasonic image to assist those specialists. We also propose an algorithm to differentiate GIST from non-GIST by fuzzy inference from such images after applying ROC curve with mean and standard deviation of brightness information. In experiments using real images that medical specialists use, we verify that our method is sufficiently helpful for such specialists for efficient classification of submucosal tumors.

  18. Gastrointestinal stromal tumor masquerading as a lung neoplasm. A case presentation and literature review

    Directory of Open Access Journals (Sweden)

    Papagiannopoulos K

    2008-05-01

    Full Text Available Abstract Gastrointestinal stromal tumors (GISTs are rare neoplasms of the gastrointestinal tract. Their incidence in the esophagus is 1%–3%. Never has a GIST been documented to directly invade the lung. We report a primary esophageal GIST with direct invasion into the lung parenchyma, presenting predominantly with respiratory symptoms. We include a retrospective literature review. Although the principle 'common things are common' usually guides our everyday clinical practice, this case emphasizes that rare entities can mimic common pathologies and underlines the importance of having a clearly defined differential diagnostic list which should be meticulously scrutinized.

  19. Current concepts in non-gastrointestinal stromal tumor soft tissue sarcomas: A primer for radiologists

    Energy Technology Data Exchange (ETDEWEB)

    Baheti, Akahay D. [Dept. of Radiology, Tata Memorial Centre, Mumbai (India); Tirumani, Harika [Dept. of Radiology, University of Arkansas for Medical Sciences, Little Rock (United States); O' Neill, Alibhe; Jagannathan, Jyothi P. [Dept. of Imaging, Dana-Farber Cancer Institute, Boston (United States)

    2017-01-15

    Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist.

  20. Current concepts in non-gastrointestinal stromal tumor soft tissue sarcomas: A primer for radiologists

    International Nuclear Information System (INIS)

    Baheti, Akahay D.; Tirumani, Harika; O'Neill, Alibhe; Jagannathan, Jyothi P.

    2017-01-01

    Non-gastrointestinal stromal tumor (GIST) soft tissue sarcomas (STSs) are a heterogeneous group of neoplasms whose classification and management continues to evolve with better understanding of their biologic behavior. The 2013 World Health Organization (WHO) has revised their classification based on new immunohistochemical and cytogenetic data. In this article, we will provide a brief overview of the revised WHO classification of soft tissue tumors, discuss in detail the radiology and management of the two most common adult non-GIST STS, namely liposarcoma and leiomyosarcoma, and review some of the emerging histology-driven targeted therapies in non-GIST STS, focusing on the role of the radiologist

  1. Drugs Approved for Gastrointestinal Stromal Tumors

    Science.gov (United States)

    This page lists cancer drugs approved by the Food and Drug Administration (FDA) for gastrointestinal stromal tumors (GIST). The list includes generic names and brand names. The drug names link to NCI's Cancer Drug Information summaries.

  2. Whaling into a spider web? The multiple international restraints to states` sovereignty / Enzo Cannizzaro

    Index Scriptorium Estoniae

    Cannizzaro, Enzo

    2016-01-01

    Vaalapüügist Antarktika vetes ja vastavast keerulisest seadusandlusest ning piirangutest rahvusvahelise õiguse kontekstis; Euroopa Kohtu lahendist (31.03.2014). Samal teemal ka artiklid lk. 1027-1069

  3. Uudised : Õhtusöök ̉ la J.S. Bach. Peeter Lilje mälestusfondist. Nana Mouskouri Tallinnas / Kerle Arula

    Index Scriptorium Estoniae

    Arula, Kerle

    2000-01-01

    19. nov. restoranis Balthasar toimuvast õhtusöögist koos Bachi muusikaga. P. Lilje nimelisest fondist interpretatsioonikunsti jäädvustamiseks. 22. nov. annab Kaarli kirikus heategevuskontserdi N. Mouskouri

  4. Miljonitehing : Kalev müüdud - jumal tänatud, kõik murest lahti / Andres Reimer, Holger Roonemaa, Vallo Toomet

    Index Scriptorium Estoniae

    Reimer, Andres

    2007-01-01

    Kalevi ja Tere toiduainetööstusettevõtete müügist investeerimisfirmale Alta Capital Partners. Vt. samas: Alta Capital Partners; Holger Roonemaa, Kristjan Jõevere. Finantsinspektsioon: Kalev rikkus head tava

  5. Laissez faire or faire mourir. The significance of participation of the clergy in the contract of purchase and sale of annuities in Central Europe between the 14th and the 15th century / Krzysztof Olendzki ; komment. Tiina Kala

    Index Scriptorium Estoniae

    Olendzki, Krzysztof

    2009-01-01

    Rendiseostust ja -müügist ning kiriklike institutsioonide osalusest selles. Raha tulu saamise eesmärgil väljalaenamist kritiseeriti. Intressi suurust üritati piirata või rendiselepinguid tühistada.

  6. Persona grata : Raido Mägi / intervjueerinud Anu Sööt

    Index Scriptorium Estoniae

    Mägi, Raido

    2011-01-01

    TÜ Viljandi kultuuriakadeemia kontaktimprovisatsiooni tantsuõpetajast Raido Mägist, kes sai eesti tantsu-uuendaja Gerd Neggo stipendiumi. Tema teest tantsu juurde, eeskujudest, kontaktimprovisatsioonist, õpetamisest ja õpilastest

  7. Geographic information systems - transportation ISTEA management systems server net prototype pooled fund study : phase B - summary

    Science.gov (United States)

    1997-06-01

    The Geographic Information System-Transportation (GIS-T) ISTEA Management Systems Server Net Prototype Pooled Fund Study represents the first national cooperative effort in the transportation industry to address the management and monitoring systems ...

  8. Enhancing Interoperability Among Enlisted Medical Personnel. A Case Study of Military Surgical Technologists

    Science.gov (United States)

    2009-01-01

    SUBSTANCE ABUSE TERRORISM AND HOMELAND SECURITY TRANSPORTATION AND INFRASTRUCTURE WORKFORCE AND WORKPLACE The RAND Corporation is a nonprofit research...of allied health careers such as radiography , clinical lab technician, surgical technolo- gist, pharmacy technician, and dental hygienist. These

  9. Lidia Iovleva : oshibalis vse! / Lidia Iovleva ; interv. Julia Tshutshalova

    Index Scriptorium Estoniae

    Iovleva, Lidia

    2008-01-01

    Tretjakovi galerii peadirektori esimese asetäitja Lidia Iovlevaga maalide autorsust kinnitavate ekslike ekspertiisidega seotud sisekontrolli tulemustest, eksimuste põhjustest. Venemaal levinud ulatuslikust kunstivõltsingute müügist

  10. Dmitri Borovkov tuli maailmameistriks!

    Index Scriptorium Estoniae

    2014-01-01

    6. septembril 2014 toimusid Poolas Szamotulys castingu maailmameistrivõistlused. Casting on spordiala, kus võisteldakse kauguse ja täpsuse peale, kasutades sportlikust kalapüügist tuntud heitevahendeid

  11. LALIGENS, Vol.4 (1), January 2015

    African Journals Online (AJOL)

    client

    2015-01-09

    Jan 9, 2015 ... details, integration of information from different parts of the text, recall of gist (for ... humans seen as limited processors in the sense that they can only ... determine types of listening – attitudinal listening, informational listening,.

  12. Bukowskisel tuleb 533. oksjon / Õnne Pärl

    Index Scriptorium Estoniae

    Pärl, Õnne, 1965-

    2004-01-01

    Skandinaavia suurimast Bukowskise oksjonifirmast. Eesti kunsti müügist Bukowskise-Hörhammeri oksjonitel. Oksjonitel on olnud väliseestlaste Herman Talviku, Joann-Voldemar Saarniidu, Hugo Lepiku ja Veronika Keerdoja teoseid

  13. Juhtimiskonsultant: Q Vara saneerimiskava kui õudusunenägu / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2009-01-01

    Võlgades Q Vara küsib võlakirjainvestoritelt nelja-aastast armuaega ning õigust maksta laenud tagasi siis, kui neile kinnisvara müügist raha laekub. Vt. samas: Q Vara võlausaldajad kannavad kaotusi

  14. "Оскар" тоже переживает кризис / Хью Джекман ; интервьюировал Мэлор Стуруа

    Index Scriptorium Estoniae

    Джекман, Хью, 1968-

    2009-01-01

    Näitleja Hugh Jackman 81. Oscarite jagamise tseremoonia eel. Samas artiklis ka "punase vaiba" defileeks ettevalmistuvate näitlejannade ilunippidest, reklaami müügist show ülekandesse ja muust tseremooniasse puutuvast

  15. Th·erapeutic Abortion

    African Journals Online (AJOL)

    1971-08-14

    Aug 14, 1971 ... abortion on the demand of any pregnant woman. Although .... Of these abortions 55% were in single, widowed, divorced or separated women and the ... gists found reluctance in nursing staff for the performance of therapeutic ...

  16. Köök on kogunemispaik / Shanti Broeng

    Index Scriptorium Estoniae

    Broeng, Shanti

    2003-01-01

    Taani abielupaari Heidi ja Dines Helmig'i 1930. aastatel ehitatud funkvillas renoveeritud köögist. Köögi projekteeris ja valmistas Taani puidufirma Simonsen og Czechura Kokkener og Mobler. Stilistid Pernille Vest, Othilia Thalund. 8 ill

  17. Kui Arno isaga ... / Kati Saara Vamann

    Index Scriptorium Estoniae

    Vatmann, Kati Saara, 1967-

    2016-01-01

    Portreelood ühise eesnimega tegusatest meestest, pankrotihaldur Arno Mägist, meelelahutajatest ja muusikutest Arno Kukest ning Arno Suislepast, spordimehest Arnold Tokkost ja pedagoogist, Sillamäe gümnaasiumi direktorist Arno Kaseniidust

  18. Drug: D09375 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available intestinal stromal tumors (GIST), Treatment of patients with relapsed and/or refractory stage IIIb (with pleural or pericardial effus...ions) or IV NSCLC HSP90 [HSA:3320 3326 7184] [KO:K04079

  19. Functional role of the Ca2+-activated Cl− channel DOG1/TMEM16A in gastrointestinal stromal tumor cells

    International Nuclear Information System (INIS)

    Berglund, Erik; Akcakaya, Pinar; Berglund, David; Karlsson, Fredrik; Vukojević, Vladana; Lee, Linkiat; Bogdanović, Darko; Lui, Weng-Onn; Larsson, Catharina; Zedenius, Jan; Fröbom, Robin; Bränström, Robert

    2014-01-01

    DOG1, a Ca 2+ -activated Cl − channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST). It was rapidly included as a tumor marker in routine diagnostics, but the functional role remained unknown. CaCCs are important regulators of normal physiological functions, but also implicated in tumorigenesis, cancer progression, metastasis, cell migration, apoptosis, proliferation and viability in several malignancies. We therefore investigated whether DOG1 plays a role in the three latter in GIST by utilizing in vitro cell model systems. Confocal microscopy identified different subcellular localizations of DOG1 in imatinib-sensitive and imatinib-resistant cells. Electrophysiological studies confirmed that DOG1-specific pharmacological agents possess potent activating and inhibiting properties. Proliferation assays showed small effects up to 72 h, and flow cytometric analysis of adherent cells with 7-AAD/Annexin V detected no pharmacological effects on viable GIST cells. However, inhibition of DOG1 conveyed pro-apoptotic effects among early apoptotic imatinib-resistant cells. In conclusion, DOG1 generates Cl − currents in GIST that can be regulated pharmacologically, with small effects on cell viability and proliferation in vitro. Inhibition of DOG1 might act pro-apoptotic on some early apoptotic GIST cell populations. Further studies are warranted to fully illuminate the function of DOG1 and its potential as therapeutic target. - Highlights: • Subcellular DOG1 localization varies between GIST cells. • DOG1 in GIST is voltage- and Ca 2+ -activated. • Known TMEM16A modulators, like A01 and Eact, modulate DOG1. • DOG1 has small effects on cell viability and proliferation in vitro. • DOG1 impact early apoptotic GIST cells to undergo late apoptosis

  20. How Fuzzy-Trace Theory Predicts True and False Memories for Words, Sentences, and Narratives

    OpenAIRE

    Reyna, Valerie F.; Corbin, Jonathan C.; Weldon, Rebecca B.; Brainerd, Charles J.

    2016-01-01

    Fuzzy-trace theory posits independent verbatim and gist memory processes, a distinction that has implications for such applied topics as eyewitness testimony. This distinction between precise, literal verbatim memory and meaning-based, intuitive gist accounts for memory paradoxes including dissociations between true and false memory, false memories outlasting true memories, and developmental increases in false memory. We provide an overview of fuzzy-trace theory, and, using mathematical model...

  1. Colorectal Mesenchymal Tumor: A Clinicopathologic Study of 25 Cases

    Directory of Open Access Journals (Sweden)

    Chen-Hui Lee

    2005-07-01

    Conclusion: Two clinicopathologically different categories were identified from our colorectal mesenchymal tumors: intramural GISTs and polypoid submucosal leiomyomas. Our study suggests that GIST is a better categorization than smooth muscle tumor because of the malignant potential. Prognosis is strictly related to the number of mitoses. However, tumor size, nuclear atypia and tumor necrosis are probably also significant predictive factors of lethality. Future studies with DNA analysis and larger patient numbers are essential to evaluate the prognostic significance of our findings.

  2. Gastrointestinal Stromal Tumor: Diagnosis and Prognosis; Tumor estromal gastrointestinal: diagnostico y pronostico

    Energy Technology Data Exchange (ETDEWEB)

    Martin, M. T.; Olmedilla, P.; Gonzalez, S.; Oliver, J. M. [Fundacion Hospital de Alcorcon. Madrid (Spain)

    2003-07-01

    Gastrointestinal stromal tumors (GIST) are mesenquimal tumors derived from cell precursors. They have the capacity for myogenic and neurogenic differentiation and are characterized by expression of KIT protein (tyrosine kinase growth factor). Clinically, they exhibit various biological behaviors. We present 8 cases of GIST, describing both their radiological manifestation through computerized tomography (CT) and most accepted criteria for benignity and malignancy. We also describe the response of one meta statically diagnosed tumor to tyrosine kinase inhibitor. (Author) 9 refs.

  3. Laparoscopic resection of large gastric gastrointestinal stromal tumours

    Directory of Open Access Journals (Sweden)

    Sebastian Smolarek

    2015-12-01

    Full Text Available Introduction : Gastrointestinal stromal tumours (GISTs are a rare class of neoplasms that are seen most commonly in the stomach. Due to their malignant potential, surgical resection is the recommended method for management of these tumours. Many reports have described the ability to excise small and medium sized GISTs laparoscopically, but laparoscopic resection of GISTs greater than 5 cm is still a matter of debate. Aim: To investigate the feasibility and effectiveness of laparoscopic surgical techniques for management of large gastric GISTs greater than 4 cm and to detail characteristics of this type of tumour. Material and methods: The study cohort consisted of 11 patients with suspected gastric GISTs who were treated from 2011 to April 2014 in a single institution. All patients underwent laparoscopic resection of a gastric GIST. Results : Eleven patients underwent laparoscopic resection of a suspected gastric GIST between April 2011 and April 2014. The cohort consisted of 6 males and 5 females. Mean age was 67 years (range: 43–92 years. Sixty-four percent of these patients presented with symptomatic tumours. Four (36.4% patients underwent laparoscopic transgastric resection (LTR, 3 (27.3% laparoscopic sleeve gastrectomy (LSG, 3 (27.3% laparoscopic wedge resection (LWR and 1 (9% laparoscopic distal gastrectomy (LDG. The mean operative time was 215 min. The mean tumour size was 6 cm (range: 4–9 cm. The mean tumour size for LTR was 5.5 cm (range: 4–6.3 cm, for LWR 5.3 cm (range: 4.5–7 cm, for LSG 6.5 cm (range: 4–9 cm and for LDG 9 cm. We experienced only minor postoperative complications. Conclusions : Laparoscopic procedures can be successfully performed during management of large gastric GISTs, bigger than 4 cm, and should be considered for all non-metastatic cases. The appropriate approach can be determined by assessing the anatomical location of each tumour.

  4. Gastrointestinal Stromal Tumor: Diagnosis and Prognosis

    International Nuclear Information System (INIS)

    Martin, M. T.; Olmedilla, P.; Gonzalez, S.; Oliver, J. M.

    2003-01-01

    Gastrointestinal stromal tumors (GIST) are mesenquimal tumors derived from cell precursors. They have the capacity for myogenic and neurogenic differentiation and are characterized by expression of KIT protein /tyrosine kinase growth factor). Clinically, they exhibit various biological behaviors. We present 8 cases of GIST, describing both their radiological manifestation through computerized tomography (CT) and most accepted criteria for benignity and malignancy. We also describe the response of one meta statically diagnosed tumor to tyrosine kinase inhibitor. (Author) 9 refs

  5. A Large Cystic Variant of Gastro-intestinal Stromal Tumour arising from the Jejunum: A Case Report

    OpenAIRE

    Shaikh, Salman Tehran; Upwanshi, Manish Harinarayan; Shetty, Tilakdas S.; Ghetla, Smruti R.; Gheewala, Hussain

    2015-01-01

    Gastrointestinal stromal tumours (GISTs) represent a mesenchymal neoplasm arising from the interstitial cells of cajal occurring mainly in the gastrointestinal tract. Here, we present a case of a large GIST arising from the jejunum with cystic presentation unlike the usual presentation as a solid mass. A 50-year-old male patient came with complaint of a painless mobile lump in abdomen of approximately 25 cm in size which had gradually increased over two years. Clinically mesenteric cyst was s...

  6. Extragastrointestinal Stromal Tumor during Pregnacy

    Directory of Open Access Journals (Sweden)

    Ilay Gözükara

    2012-01-01

    Full Text Available Extragastrointestinal stromal tumors (EGISTs are mesenchymal neoplasms without connection to the gastrointestinal tract. Gastrointestinal stromal tumors (GISTs and EGIST are similar according to their clinicopathologic and histomorphologic features. Both of them most often express immunoreactivity for CD-117, a c-kit proto-oncogene protein. The coexistence of GIST and pregnancy is very rare, with only two cases reported in the literature. In this paper, we presented the first EGIST case during pregnancy in the literature.

  7. Surgical management of acutely presenting gastrointestinal stromal tumors of the stomach among elderly: experience of an emergency surgery department.

    Science.gov (United States)

    Marano, Luigi; Arru, Giovanni Maria Antonio; Piras, Mario; Fiume, Stefania; Gemini, Sergio

    2014-01-01

    The incidence of gastrointestinal stromal tumors (GISTs), requiring often an emergency surgical management, is extremely rare among elderly. We aimed to present the experience of the Emergency Surgery Department, Brotzu Hospital, in the management of elderly patients with GIST related emergencies. This study was carried out on 12 patients with gastrointestinal stromal tumors who presented to in an emergency situation during the period from January 2010 to December 2013. All patients' data, clinical presentations, surgical procedures, complications, and survival data were collected and analyzed. Between 2010 and 2013, 12 patients (8 males and 4 females), with a mean age of 70 years (range: 65-79 years) were admitted with different emergency presentations of clinically and radiologically suspected GISTs. The incidence of proximal obstruction was 41.7% of all gastric GIST cases, resulting acute gastrointestinal bleeding and perforation in 41.7% and 16.6% respectively. The mean length of hospitalization was 9.1 ± 2.3 days and there were no posterative complications or mortalities. At a mean follow-up of 21 months, 11 patients (91.6%) were alive and disease free. Although GISTs are uncommon among elderly, their incidence is increasing especially in their emergency presentation and surgeon should be prepared to treat this condition following the principles of GIST surgery as stated by the GIST consensus conference. In conclusion our data demonstrate that age itself does not affect the outcome of surgical treatment of GISTs in emergency situation. Copyright © 2014 Surgical Associates Ltd. Published by Elsevier Ltd. All rights reserved.

  8. Functional role of the Ca{sup 2+}-activated Cl{sup −} channel DOG1/TMEM16A in gastrointestinal stromal tumor cells

    Energy Technology Data Exchange (ETDEWEB)

    Berglund, Erik, E-mail: erik.berglund@ki.se [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm (Sweden); Akcakaya, Pinar [Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm (Sweden); Berglund, David [Section for Transplantation Surgery, Department of Surgical Sciences, Uppsala University Hospital, Uppsala (Sweden); Karlsson, Fredrik [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm (Sweden); Vukojević, Vladana [Department of Clinical Neuroscience, Karolinska Institutet, Stockholm (Sweden); Lee, Linkiat [Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm (Sweden); Bogdanović, Darko [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Lui, Weng-Onn; Larsson, Catharina [Department of Oncology-Pathology, Karolinska Institutet, Cancer Center Karolinska, Stockholm (Sweden); Zedenius, Jan [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm (Sweden); Fröbom, Robin [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Bränström, Robert [Endocrine and Sarcoma Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm (Sweden); Department of Breast and Endocrine Surgery, Karolinska University Hospital, Stockholm (Sweden)

    2014-08-15

    DOG1, a Ca{sup 2+}-activated Cl{sup −} channel (CaCC), was identified in 2004 to be robustly expressed in gastrointestinal stromal tumors (GIST). It was rapidly included as a tumor marker in routine diagnostics, but the functional role remained unknown. CaCCs are important regulators of normal physiological functions, but also implicated in tumorigenesis, cancer progression, metastasis, cell migration, apoptosis, proliferation and viability in several malignancies. We therefore investigated whether DOG1 plays a role in the three latter in GIST by utilizing in vitro cell model systems. Confocal microscopy identified different subcellular localizations of DOG1 in imatinib-sensitive and imatinib-resistant cells. Electrophysiological studies confirmed that DOG1-specific pharmacological agents possess potent activating and inhibiting properties. Proliferation assays showed small effects up to 72 h, and flow cytometric analysis of adherent cells with 7-AAD/Annexin V detected no pharmacological effects on viable GIST cells. However, inhibition of DOG1 conveyed pro-apoptotic effects among early apoptotic imatinib-resistant cells. In conclusion, DOG1 generates Cl{sup −} currents in GIST that can be regulated pharmacologically, with small effects on cell viability and proliferation in vitro. Inhibition of DOG1 might act pro-apoptotic on some early apoptotic GIST cell populations. Further studies are warranted to fully illuminate the function of DOG1 and its potential as therapeutic target. - Highlights: • Subcellular DOG1 localization varies between GIST cells. • DOG1 in GIST is voltage- and Ca{sup 2+}-activated. • Known TMEM16A modulators, like A01 and Eact, modulate DOG1. • DOG1 has small effects on cell viability and proliferation in vitro. • DOG1 impact early apoptotic GIST cells to undergo late apoptosis.

  9. CCR 20th Anniversary Commentary: A Genetic Mechanism of Imatinib Resistance in Gastrointestinal Stromal Tumor-Where Are We a Decade Later?

    Science.gov (United States)

    Antonescu, Cristina R; DeMatteo, Ronald P

    2015-08-01

    In the June 1, 2005, issue of Clinical Cancer Research, Antonescu and colleagues defined second-site KIT mutations in gastrointestinal stromal tumor (GIST) as the leading mechanism of acquired resistance to imatinib. Secondary mutations were detectable mainly in KIT exon 11 mutant GISTs after prolonged initial clinical responses. These findings played a critical role in designing the next generation of tyrosine kinase inhibitors. ©2015 American Association for Cancer Research.

  10. Early Evaluation of Response Using 18F-FDG PET Influences Management in Gastrointestinal Stromal Tumor Patients Treated with Neoadjuvant Imatinib.

    Science.gov (United States)

    Farag, Sheima; Geus-Oei, Lioe-Fee de; van der Graaf, Winette T; van Coevorden, Frits; Grunhagen, Dirk; Reyners, Anna K L; Boonstra, Pieter A; Desar, Ingrid; Gelderblom, Hans; Steeghs, Neeltje

    2018-02-01

    18 F-FDG PET has previously been proven effective as an early way to evaluate the response of gastrointestinal stromal tumors (GISTs) to imatinib treatment. However, it is unclear whether early evaluation of response affects treatment decisions in GIST patients treated with neoadjuvant intent. Methods: We retrospectively scored changes in management based on early evaluation of response by 18 F-FDG PET in patients in the Dutch GIST registry treated with neoadjuvant imatinib. Results: Seventy 18 F-FDG PET scans were obtained for 63 GIST patients to evaluate for an early response to neoadjuvant imatinib. The scans led to a change in management in 27.1% of the patients. Change in management correlated strongly with lack of metabolic response ( P PET for early evaluation of response often results in a change of management in GIST patients harboring the non- KIT exon 11 mutation and should be considered the standard of care in GIST patients treated with neoadjuvant intent. © 2018 by the Society of Nuclear Medicine and Molecular Imaging.

  11. Comparison of Endoscopic and Open Resection for Small Gastric Gastrointestinal Stromal Tumor

    Directory of Open Access Journals (Sweden)

    Fan Feng

    2015-12-01

    Full Text Available The National Comprehensive Cancer Network recommends conservative follow-up for gastric gastrointestinal stromal tumors (GISTs less than 2 cm. We have previously reported that the mitotic index of 22.22% of small gastric GISTs exceeded 5 per 50 high-power fields and recommended that all small gastric GISTs should be resected once diagnosed. The aim of the present study is to compare the safety and outcomes of endoscopic and open resection of small gastric GISTs. From May 2010 to March 2014, a total of 90 small gastric GIST patients were enrolled in the present study, including 40 patients who underwent surgical resection and 50 patients who underwent endoscopic resection. The clinicopathological characteristics, resection-related factors, and clinical outcomes were recorded and analyzed. The clinicopathological characteristics were comparable between the two groups except for tumor location and DOG-1 expression. Compared with the surgical resection group, the operation time was shorter (P = .000, blood loss was less (P = .000, pain intensity was lower (P < .05, duration of first flatus and defecation was shorter (P < .05, and medical cost of hospitalization was lower (P = .027 in the endoscopic resection group. The complications and postoperative hospital stay were comparable between the two groups. No in situ recurrence or liver metastasis was observed during follow-up. Endoscopic resection of small gastric GISTs is safe and feasible compared with surgical resection, although perforation could not be totally avoided during and after resection. The clinical outcome of endoscopic resection is also favorable.

  12. Sunitinib in the treatment of gastrointestinal stromal tumor: patient selection and perspectives

    Directory of Open Access Journals (Sweden)

    Mulet-Margalef N

    2016-12-01

    Full Text Available Nuria Mulet-Margalef, Xavier Garcia-del-Muro Sarcoma Multidisciplinary Unit and Medical Oncology Department, Institut Català d’Oncologia Hospitalet, IDIBELL, Barcelona, Spain Abstract: Gastrointestinal stromal tumor (GIST is the most common mesenchymal tumor of the gastrointestinal tract. In advanced setting and after progression to imatinib, the multitargeted receptor tyrosine kinase inhibitor sunitinib has clearly demonstrated a clinical benefit in terms of response rate and progression-free survival with an acceptable toxicity profile. The recommended schedule for sunitinib administration is 50 mg per day 4 weeks ON and 2 weeks OFF; however, potential alternative schedules are also reviewed in the present article. Several biomarkers have been explored to better select candidates for sunitinib therapy, such as the value of early changes in standardized uptake value assessed by positron emission tomography with 18F-fluorodeoxyglucose, circulating biomarkers, clinical biomarkers such as the appearance of arterial hypertension during treatment that correlates with better outcomes, and the GIST genotype. GISTs with KIT mutations at exon 9 and the so-called wild-type GISTs seem to better respond to sunitinib. Nonetheless, further investigation is required to confirm these findings as well as to understand the mechanisms of sunitinib resistance such as the development of new KIT mutations or conformational changes in KIT receptor. Keywords: sunitinib, GIST, KIT, refractory GIST

  13. Robot-Assisted Excision of a Pararectal Gastrointestinal Stromal Tumor in a Patient with Previous Ileal Neobladder

    Directory of Open Access Journals (Sweden)

    A. Ploumidis

    2014-01-01

    Full Text Available Gastrointestinal stromal tumors (GISTs are the most frequent mesenchymal tumors of the gastrointestinal tract with surgical resection remaining the cornerstone of therapy. Pararectal lesions are considered to be technically difficult and pose in some cases a challenge. We report, to the best of our knowledge, the first robotic-assisted pararectal GIST excision. A 43-year-old man was referred to our center with pararectal GIST recurrence, despite treatment with targeted therapy. Eleven years ago, he underwent extensive abdominal surgery including cystoprostatectomy with ileal neobladder diversion due to GIST resection in the rectoprostatic space. Robot-assisted surgical resection was successfully performed without the need for temporary colostomy. The postoperative course of the patient was uneventful, and the pathology report confirmed a GIST recurrence with negative surgical margins and pelvic lymph nodes free of any tumor. Robotic-assisted pelvic surgery can be extended to incorporate excision of pararectal GISTs, as a safe, less invasive surgical alternative with promising oncological results and minimal injury to adjacent structures.

  14. Multifocal small bowel stromal tumours presenting with peritonitis in an HIV positive patient.

    Science.gov (United States)

    Mansoor, Ebrahim

    2014-01-01

    The most common mesenchymal tumour of the gastrointestinal tract is stromal tumours (GISTs). Symptomatic GISTs can present with complications such as haemorrhage, obstruction and perforation. Complete surgical resection with negative margins is the mainstay of treatment but may be imprudent on emergent occasion. Tyrosine-kinase inhibitors (TKIs) have been revolutionary in the treatment of GISTs and have resulted in improved outcomes. A 41 year old HIV positive male presented with an acute history of abdominal pain and obstructive symptoms. Clinical examination revealed sepsis and peritonitis. One of the several small bowel tumours discovered at exploratory laparotomy was necrotic and perforated. The perforated tumour alone was resected and a small bowel internal hernia reduced. The patient made an uneventful recovery and will be considered for TKI therapy with a view to later re-operation. GISTs very rarely perforate. The pathophysiology of stromal tumour necrosis is poorly understood. Multifocality and small bowel location are poor prognosticators and may occur in the setting of familial GISTs, specific syndromes and sporadic cases. There is no established association between HIV and GISTs. Perforation occurs infrequently in ≤8% of symptomatic cases and poses increased risk of local recurrence. The surgical management of perforation takes precedence in an emergency. The surgeon must however take cognisance of the adherence to ideal oncologic principles where feasible. TKI therapy is invaluable if a re-exploration is to be later considered. Copyright © 2014 The Author. Published by Elsevier Ltd.. All rights reserved.

  15. The nitrogen doping effect on the properties of Ge-In-Sb-Te phase-change recording media investigated by blue-light laser

    International Nuclear Information System (INIS)

    Yeh, T.-T.; Hsieh, T.-E.; Shieh, H.-P.D.

    2005-01-01

    This work investigates the thermal, optical and recrystallization properties as well as the microstructure of nitrogen-doped Ge-In-Sb-Te (GIST) phase-change material when irradiated by blue-light laser. The experimental results showed that nitrogen doping at the condition of N 2 /Ar sputtering gas flow ratio equals to 3% might enhance the recrystallization speed of GIST recording layer up to 1.5 times. However, the disk failed when too much nitrogen (N 2 /Ar ≥ 5.0%) was introduced. The data obtained by differential scanning calorimetry, X-ray diffraction and ellipsometry revealed changes of thermal and optical properties due to the nitrogen doping in GIST. When appropriate amount of nitrogen was added, the activation energy (E a ) of amorphous-crystalline phase transition of GIST decreased and the optical constants of amorphous and crystalline phases (except the k value of amorphous phase) gradually reduced with the increase of wavelength in the range of 600-750 nm. Modulation simulation based on the reflectively of doped GIST layers obtained from static test indicated that appropriate nitrogen doping benefited the signal characteristics of optical disks. Transmission electron microscopy observed numerous tiny precipitates uniformly distributed in the doped GIST layers. These were believed to be nitride particles generated by nitrogen doping that might offer the preferential sites for amorphous-crystalline phase transition so that the recrystallization speed was accelerated

  16. Differentiation of large (≥5 cm) gastrointestinal stromal tumors from benign subepithelial tumors in the stomach: Radiologists’ performance using CT

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ye Ra [Department of Radiology, Seoul National University Hospital (Korea, Republic of); Kim, Se Hyung, E-mail: shkim7071@gmail.com [Department of Radiology, Seoul National University Hospital (Korea, Republic of); The Institute of Radiation Medicine, Seoul National University Hospital (Korea, Republic of); Kim, Sun-Ah [Department of Radiology, Seoul National University Hospital (Korea, Republic of); Shin, Cheong-il [Department of Radiology, Seoul National University Hospital (Korea, Republic of); The Institute of Radiation Medicine, Seoul National University Hospital (Korea, Republic of); Kim, Hyung Jin; Kim, Seong Ho [Department of Radiology, Seoul National University Hospital (Korea, Republic of); Han, Joon Koo; Choi, Byung Ihn [Department of Radiology, Seoul National University Hospital (Korea, Republic of); The Institute of Radiation Medicine, Seoul National University Hospital (Korea, Republic of)

    2014-02-15

    Purpose: To identify significant CT findings for the differentiation of large (≥5 cm) gastric gastrointestinal stromal tumors (GIST) from benign subepithelial tumors and to assess whether radiologists’ performance in differentiation is improved with knowledge of significant CT criteria. Materials and methods: One-hundred twenty patients with pathologically proven large (≥5 cm) GISTs (n = 99), schwannomas (n = 16), and leiomyomas (n = 5) who underwent CT were enrolled. Two radiologists (A and B) retrospectively reviewed their CT images in consensus for the location, size, degree and pattern of enhancement, contour, growth pattern and the presence of calcification, necrosis, surface ulceration, or enlarged lymph nodes. CT findings considered significant for differentiation were determined using uni- and multivariate statistical analyses. Thereafter, two successive review sessions for the differentiation of GIST from non-GIST were independently performed by two other reviewers (C and D) with different expertise of 2 and 9 years using a 5-point confidence scale. At the first session, reviewers interpreted CT images without knowledge of significant CT findings. At the second session, the results of statistical analyses were provided to the reviewers. To assess improvement in radiologists’ performance, a pairwise comparison of receiver operating curves (ROC) was performed. Results: Heterogeneous enhancement, presence of necrosis, absence of lymph nodes, and mean size of ≥6 cm were found to be significant for differentiating GIST from schwannoma (P < 0.05). Non-cardial location, heterogeneous enhancement, and presence of necrosis were differential CT features of GIST from leiomyoma (P < 0.05). Multivariate analyses indicated that absence of enlarged LNs was the only statistically significant variable for GIST differentiating from schwannoma. The area under the curve of both reviewers obtained using ROC significantly increased from 0.682 and 0.613 to 0.903 and 0

  17. Canine and human gastrointestinal stromal tumors display similar mutations in c-KIT exon 11

    International Nuclear Information System (INIS)

    Gregory-Bryson, Emmalena; Bartlett, Elizabeth; Kiupel, Matti; Hayes, Schantel; Yuzbasiyan-Gurkan, Vilma

    2010-01-01

    Gastrointestinal stromal tumors (GISTs) are common mesenchymal neoplasms in the gastrointestinal tract of humans and dogs. Little is known about the pathogenesis of these tumors. This study evaluated the role of c-KIT in canine GISTs; specifically, we investigated activating mutations in exons 8, 9, 11, 13, and 17 of c-KIT and exons 12, 14, and 18 of platelet-derived growth factor receptor, alpha polypeptide (PDGFRA), all of which have been implicated in human GISTs. Seventeen canine GISTs all confirmed to be positive for KIT immunostaining were studied. Exons 8, 9, 11, 13 and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA, were amplified from DNA isolated from formalin-fixed paraffin-embedded samples. Of these seventeen cases, six amplicons of exon 11 of c-KIT showed aberrant bands on gel electrophoresis. Sequencing of these amplicons revealed heterozygous in-frame deletions in six cases. The mutations include two different but overlapping six base pair deletions. Exons 8, 9, 13, and 17 of c-KIT and exons 12, 14, and 18 of PDGFRA had no abnormalities detected by electrophoresis and sequencing did not reveal any mutations, other than synonymous single nucleotide polymorphisms (SNPs) found in exon 11 of c-KIT and exons 12 and 14 of PDGFRA. The deletion mutations detected in canine GISTs are similar to those previously found in the juxtamembrane domain of c-KIT in canine cutaneous mast cell tumors in our laboratory as well as to those reported in human GISTs. Interestingly, none of the other c-KIT or PDGFRA exons showed any abnormalities in our cases. This finding underlines the critical importance of c-KIT in the pathophysiology of canine GISTs. The expression of KIT and the identification of these activating mutations in c-KIT implicate KIT in the pathogenesis of these tumors. Our results indicate that mutations in c-KIT may be of prognostic significance and that targeting KIT may be a rational approach to treatment of these malignant tumors. This study further

  18. Distrofia policromática posterior da córnea

    OpenAIRE

    Coelho, Letícia Maria; Muinhos, Guilherme Kfoury; Tanure, Marco Antônio Guarino; Almeida, Homero Gusmão de; Sieiro, Reinaldo de Oliveira

    2015-01-01

    Os autores descrevem dois casos de distrofia policromática posterior da córnea, uma distrofia pré-Descemet, pouco descrita nas literaturas nacional e mundial, em que se observam pontos policromáticos difusos no estroma posterior da córnea, sem aparente comprometimento da visão. The authors describe two cases of posterior polychromatic corneal dystrophy, a pre-Descemet dystrophy, poorly described in national and world literatures, characterized by diffuse polychromatic points on the posteri...

  19. Concentração do ácido hialurônico e dos pequenos proteoglicanos ricos em leucina no endométrio de pacientes com síndrome dos ovários policísticos em comparação a de mulheres eumenorreicas

    OpenAIRE

    Ricardo dos Santos Simões

    2015-01-01

    INTRODUÇÃO: A matriz extracelular no endométrio fornece vasta gama de sinais envolvidos em diferentes processos celulares, tais como morte celular e proliferação. Neste sentido, os glicosaminoglicanos e os proteoglicanos, juntamente com os fatores de crescimento, modulam várias etapas da angiogênese, proliferação celular e remodelação do estroma, o que pode ser importante para o fluxo menstrual regular e a redução dos processos proliferativos. Além disso, são importantes para a adequada inter...

  20. Granular corneal dystrophy

    OpenAIRE

    Castillo Pérez, Alexeide de la C; Vilches Lescaille, Daysi; Noriega, Justo Luis; Martínez Balido, Daneel; León Balbón, Bárbaro Ramón; León Bernal, Danysleidi

    2015-01-01

    Las distrofias corneales constituyen un conjunto de enfermedades que presentan, en su mayoría, una baja incidencia y se caracterizan por acúmulo de material hialino o amiloide que disminuyen la transparencia corneal. La distrofia granular es una enfermedad autosómica dominante que presenta opacidades grises en el estroma superficial central de la córnea y se hacen visibles en la primera y segunda décadas de la vida, lo que provoca disminución de la visión más significativa cerca de los 40 año...

  1. Patrones de infiltración leucocitaria y de expresión tisular de quimioquinas, factor de crecimiento endotelial vascular y mediadores del metabolismo oxidativo en lesiones inflamatorias y neoplásicas de cervix

    OpenAIRE

    Carrero Castillo, Yenddy Nayghit

    2012-01-01

    En nuestro trabajo de investigación sobre el patrón de infiltración leucocitaria de epitelio y estroma uterino y de la expresión tisular de quimioquinas, factor de crecimiento endotelial vascular y metabolitos oxidativos en pacientes con displasia epitelial, con cervicitis sin alteración displásica y controles sanos se concluye que: La progresión en el grado de displasia epitelial se asocia a una mayor y selectiva infiltración de linfocitos sin modificaciones en la estirpe monicitaria y la re...

  2. Anterior stromal puncture in the treatment of bullous keratopathy

    OpenAIRE

    Gomes, José Alvaro Pereira; Haraguchi, Daniel Keizo de Medeiros; Zambrano, Delbis Uzcátegui; Villavicencio, Luis Izquierdo; Cunha, Marcelo C.; Freitas, Denise de

    2000-01-01

    Objetivo: Avaliar o efeito terapêutico das punções do estroma anterior corneal em pacientes com ceratopatia bolhosa (CB). Métodos:Vinte e cinco pacientes com CB sintomáticos, com baixa visão, com e sem indicação de transplante de córnea, foram avaliados antes, uma, 4 e 12 semanas após punções estromais anteriores realizadas com agulha #25 à lâmpada de fenda. Em cada visita, os pacientes foram questionados sobre intensidade da dor, fotofobia, sensação de corpo estranho, além de serem submetido...

  3. Ocorrência de Passalora bougainvilleae (Muntañola) Castañeda & Braun associado à Bougainvillea spectabilis Willd. em Boa Vista, Roraima

    OpenAIRE

    Nechet,Kátia de Lima; Halfeld-Vieira,Bernardo A.

    2008-01-01

    O fungo Passalora bougainvilleae é relatado, pela primeira vez, na região de Boa Vista, Roraima, associado a manchas foliares na planta ornamental Bougainvillea spectabilis. As características do fungo são conidióforos agregados em fascículos, emergindo de um estroma subcuticular na face abaxial de lesões velhas. Os conidióforos são lisos, retos, de coloração marrom, não ramificados, maioria asseptados, medindo de 26-57µm x 4µm. Células conidiogênicas terminais de proliferação simpodial com c...

  4. Repot of Passalora bougainvilleae (Muntañola) Castañeda & Braun associated with Bougainvillea spectablis Willd. in Boa Vista, Roraima

    OpenAIRE

    Nechet, Kátia de Lima; Halfeld-Vieira, Bernardo A.

    2008-01-01

    O fungo Passalora bougainvilleae é relatado, pela primeira vez, na região de Boa Vista, Roraima, associado a manchas foliares na planta ornamental Bougainvillea spectabilis. As características do fungo são conidióforos agregados em fascículos, emergindo de um estroma subcuticular na face abaxial de lesões velhas. Os conidióforos são lisos, retos, de coloração marrom, não ramificados, maioria asseptados, medindo de 26-57µm x 4µm. Células conidiogênicas terminais de proliferação simpodial com c...

  5. Posibilidad regenerativa y reparadora de estructuras dentarias de células mesenquimáticas post natales

    OpenAIRE

    Siragusa, Martha

    2014-01-01

    Objetivos: Presentar evidencias clínicas de la capacidad reparativa y de la formación de nuevos tejidos mineralizados en dientes con apices incompletamente desarrollados y diagnóstico de necrosis pulpar. Ha sido demostrado que las células pulpares adultas y las del ligamento periodontal presentan un comportamiento similar en su morfología y que la superficie cellular responde positivamente a marcadores de hueso, tejido adiposo, músculos y al estroma de tejido conectivo. La posibilid...

  6. TUMOR CONDROLIPOMATOSO (CONDROLIPOMA) DE MAMA

    OpenAIRE

    Sandoval, Diana Katherine; Acevedo R, Melina; Arias V, Carmen Ligia; García A, Ernesto

    2015-01-01

    Introducción: El cartílago es un componente poco común en las lesiones de mama, la mayoría de casos corresponden a metaplasias de lesiones malignas siendo excepcional el hallazgo en lesiones benignas; estas últimas se han subclasificado de acuerdo a las características histológicas destacables para cada autor, pero globalmente se componen de tejido adiposo, estroma fibroso y cartílago, mientras que el componente epitelial mamario es de presentación variable. El condrolipoma de mama fue report...

  7. Síndrome dos Ovários Policísticos: Avaliação Dopplerfluxométrica

    Directory of Open Access Journals (Sweden)

    Bruno Ricardo Vasconcellos

    2001-01-01

    Full Text Available Objetivo: avaliar a eficácia do Doppler colorido como método diagnóstico na síndrome dos ovários policísticos (SOP, mediante as variações do fluxo sangüíneo no estroma ovariano, nas artérias uterinas e no tecido subendometrial. Métodos: foram selecionadas trinta pacientes distribuídas em dois grupos: quinze com amenorréia ou oligomenorréia, hirsutismo (índice de Ferriman e Gallwey >8, índice de massa corporal IMC maior que 25 kg/m² e exame ecográfico que identificou estroma aumentado, hiperecogênico e policistose ovariana (grupo de estudo, e número idêntico de pacientes com ciclos menstruais normais, sem sinais de hirsutismo e ultra-sonografia normal (grupo controle. Com o uso da dopplerfluxometria transvaginal foram medidas a velocidade de pico sistólico ou velocidade máxima (Vmáx, índice de pulsatilidade (IP e resistência dos vasos do estroma ovariano, da artéria uterina e do subendométrio. Resultados: a dopplervelocimetria mostrou Vmáx significativamente maior no estroma ovariano das pacientes com SOP (12,2 cm/s (p<=0,0004 em relação ao grupo controle (8,5 cm/s. O IP da artéria uterina também se revelou muito superior no grupo com SOP (3,3 cm/s em relação ao controle (2,7 cm/s. Outros parâmetros da dopplervelocimetria não evidenciaram diferença significativa. Ao estabelecermos um cutoff (ponto de corte = 9 cm/s na amostragem para a Vmáx obtivemos os percentuais de 95,2 para sensibilidade, 80,0 para especificidade e de 83,3 para o valor preditivo positivo e 94,1 para o negativo. Com referência ao IP para um cutoff = 2.35 os testes revelaram: sensibilidade de 81,0%, especificidade de 50,0%, valor preditivo positivo de 63,0% e negativo de 71,4%. Conclusão: a dopplervelocimetria pode constituir subsídio a ser incorporado à investigação clínica e ultra-sonográfica no tocante ao diagnóstico da síndrome dos ovários policísticos.

  8. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

    Directory of Open Access Journals (Sweden)

    Call Jerry

    2012-03-01

    Full Text Available Abstract Background Gastrointestinal stromal tumors (GIST, one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. Methods This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P Results Inflections in gender ratios by age at diagnosis in years delineated two distinct groups: above and below age 35 at diagnosis. Closer analysis confirmed the above 35 age group as previously reported for adult-type GIST, typified by mixed primary tumor sites and gender, KIT or PDGFRα mutations, and shorter survival times. The pediatric group ( Conclusions Pediatric- and adult-type GIST have been previously characterized in clinical settings and these observations confirm significant prognostic factors for each from a diverse real-world cohort. Additionally, these findings suggest that extra diligence be taken with "young adults" (aged 18-35 at diagnosis as pediatric-type GIST may present well beyond adolescence, particularly as these distinct sub-types have different causes, and consequently

  9. A phase II trial of regorafenib in patients with metastatic and/or a unresectable gastrointestinal stromal tumor harboring secondary mutations of exon 17.

    Science.gov (United States)

    Yeh, Chun-Nan; Chen, Ming-Huang; Chen, Yen-Yang; Yang, Ching-Yao; Yen, Chueh-Chuan; Tzen, Chin-Yuan; Chen, Li-Tzong; Chen, Jen-Shi

    2017-07-04

    Gastrointestinal stromal tumors (GISTs) are caused by the constitutive activation of KIT or platelet-derived growth factor receptor alpha (PDGFRA) mutations. Imatinib selectively inhibits KIT and PDGFR, leading to disease control for 80%-90% of patients with metastatic GIST. Imatinib resistance can occur within a median of 2-3 years due to secondary mutations in KIT. According to preclinical studies, both imatinib and sunitinib are ineffective against exon 17 mutations. However, the treatment efficacy of regorafenib for patients with GIST with exon 17 mutations is still unknown. Documented patients with GIST with exon 17 mutations were enrolled in this study. Patients received 160 mg of oral regorafenib daily on days 1-21 of a 28-day cycle. The primary end point of this trial was the clinical benefit rate (CBR; i.e., complete or partial response [PR], as well as stable disease [SD]) at 16 weeks. The secondary end points of this study included progression free survival (PFS), overall survival, and safety. Between June 2014 to May 2016, 18 patients were enrolled (15 of which were eligible for response evaluation). The CBR at 16 weeks was 93.3% (14 of 15; 6 PR and 8 SD). The median PFS was 22.1 months. The most common grade 3 toxicities were hand-and-foot skin reactions (10 of 18; 55.6%), followed by hypertension (5 of 18; 27.8%). Regorafenib significantly prolonged PFS in patients with advanced GIST harboring secondary mutations of exon 17. A phase III trial of regorafenib versus placebo is warranted. This trial is registered at ClinicalTrials.gov in November 2015, number NCT02606097.Key message: This phase II trial was conducted to assess the efficacy and safety of regorafenib in patients with GIST with exon 17 mutations. The results provide strong evidence that regorafenib significantly prolonged PFS in patients with advanced GIST harboring secondary mutations of exon 17.

  10. New developments in management of gastrointestinal stromal tumors: regorafenib, the new player in the team

    Directory of Open Access Journals (Sweden)

    Boichuk S

    2013-12-01

    Full Text Available Sergei Boichuk,1,2 Jessica L Rausch,1 Anette Duensing1,31Cancer Virology Program, University of Pittsburgh Cancer Institute, Hillman Cancer Center, Pittsburgh, PA, USA; 2Department of Pathology, Kazan State Medical University, Kazan, Russia; 3Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Gastrointestinal stromal tumors (GISTs are the most common mesenchymal tumors of the gastrointestinal tract and the most frequent single type of sarcoma, at least in some geographical regions. They arise from the interstitial cells of Cajal (or a common progenitor cell. The vast majority of GISTs are characterized by oncogenically activating mutations in the KIT or platelet-derived growth factor receptor alpha (PDGFRA receptor tyrosine kinase genes. This molecular feature has been successfully exploited for therapeutic purposes, and as of a decade ago, GISTs have become the prototype of a solid tumor that can be targeted with small molecule kinase inhibitors. Imatinib mesylate (Gleevec®/Glivec® benefits more than 85% of patients with unresectable and/or metastatic GIST. Unfortunately, the majority of patients develop resistance to imatinib within the first 2 years of treatment and new therapeutic options are needed. Although the broad-range kinase inhibitor sunitinib malate (Sutent® has been the second-line therapy approved by the US Food and Drug Administration since 2006, it was not until recently (February 2013 that regorafenib (Stivarga® was approved as a third-line therapeutic agent for GIST. This review summarizes the development process of regorafenib for GIST and highlights its biochemical, pharmacologic, and clinical properties.Keywords: gastrointestinal stromal tumors, GIST, regorafenib

  11. PROSPECÇÃO TECNOLÓGICA SOBRE PROBIÓTICOS ORIUNDOS DE MICRORGANISMOS PRESENTES NO LEITE HUMANO

    OpenAIRE

    Mendes, Herminio Benitez; Universidade Federal do Maranhão; Firmo, Wellyson da Cunha Araújo; Universidade Federal do Maranhão; Costa, Helmara Diniz; Universidade Federal do Maranhão; Gostinski, Luana Fontoura; Universidade Federal do Maranhão; Cruz, Gustavo Barbosa Vieira; Universidade Federal do Maranhão; Dias, Isabel Cristina Lopes; Universidade Federal do Mranhão; Monteiro-Neto, Valério; Universidade CEUMA/Universidade federal do Maranhão

    2015-01-01

    O uso de alimentos contendo bactérias pro bióticas foi recentemente considerado uma possibilidade de prevenção contra a instalação ou atenuação de um processo infeccioso, principalmente as espécies pertencentes aos gêneros Bifidobacterium e Lactobacillus que predominam na microbiota gastrintestinal e que são amplamente utilizadas em alimentos funcionais. O presente trabalho teve como objetivo fazer um levantamento das pesquisas já desenvolvidas, analisando as potencialidades e a evolução das ...

  12. Fisiopatologia da deficiência de vitamina B12 e seu diagnóstico laboratorial

    OpenAIRE

    Paniz,Clóvis; Grotto,Denise; Schmitt,Gabriela Cristina; Valentini,Juliana; Schott,Karen Lílian; Pomblum,Valdeci Juarez; Garcia,Solange Cristina

    2005-01-01

    INTRODUÇÃO: A vitamina B12 é hidrossolúvel, não-sintetizada pelo organismo humano, presente em alimentos de origem animal. Sua deficiência é muito freqüente entre idosos, vegetarianos e indivíduos que adotam baixa dieta protéica ou apresentam problemas de absorção gastrintestinal. FISIOPATOLOGIA: A deficiência de vitamina B12 leva a transtornos hematológicos, neurológicos e cardiovasculares, principalmente, por interferir no metabolismo da homocisteína (Hcy) e nas reações de metilação do orga...

  13. Avaliação clínica, endoscópica e histopatológica de cães com doença inflamatória intestinal

    OpenAIRE

    Cascon, Clarice M.; Mello, Marcela F.V.; Leite, Juliana S.; Ferreira, Ana M.R.

    2017-01-01

    RESUMO: O presente estudo teve como objetivo avaliar macro e microscopicamente a mucosa gastrintestinal de cães domiciliados, que apresentaram sinais gastrintestinais crônicos, por meio de exame endoscópico e da avaliação histopatológica. Os sinais clínicos, a macro e a microscopia das mucosas gástrica e duodenal foram correlacionados. Foram avaliados 20 cães de diferentes raças, sendo 7 machos e 13 fêmeas, com idade variando entre 1,7 a 15,8 anos, que apresentavam cronicidade dos sinais cara...

  14. Jejum alimentar e qualidade da carne de frango de corte tipo caipira

    OpenAIRE

    OLIVEIRA,Felipe Rosa; BOARI,Cleube Andrade; PIRES,Aldrin Vieira; MOGNATO,João Carlos; CARVALHO,Rúbio Madureira de Souza; SANTOS JÚNIOR,Marco Aurélio; MATTIOLI,Cristiano Campos

    2015-01-01

    ResumoObjetivou-se avaliar as características de qualidade da carne de frango de corte tipo caipira em diferentes tempos de jejum alimentar. Aves, machos, da linhagem “pesadão vermelho”, criadas até 85 dias de idade em sistema semiextensivo, foram submetidas aos tempos de zero, três, seis, nove e 12 horas de jejum alimentar. Obteve-se o peso vivo, peso da carcaça, o rendimento de carcaça fria, o peso do trato gastrintestinal das aves. Foram avaliados o pH24h, a luminosidade (L*), ...

  15. Aspectos nutricionais na população de pacientes com síndrome do intestino irritável atendidos no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo

    OpenAIRE

    Daiana Amarante

    2013-01-01

    INTRODUÇÃO: A síndrome do intestino irritável (SII) é uma doença funcional do trato gastrintestinal que afeta até 20% da população adulta. Os principais sintomas envolvem o mau funcionamento do intestino, associados com dores abdominais, manifestação de diarreia ou constipação, sem alterações estruturais e bioquímicas do intestino. A maneira mais adequada de tratar o paciente é por meio de uma abordagem ampla e integral, porém individualizada, com identificação dos fatores desencadeantes e/ou...

  16. Evaluation of the Novel Monoclonal Antibody Against DOG1 as a Diagnostic Marker for Gastrointestinal Stromal Tumors

    International Nuclear Information System (INIS)

    Abdel-Hadi, M.; Hamam, S.M.; Bessa, S.S.

    2009-01-01

    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract. With the growing effectiveness and availability of first and second-generation tyrosine kinase inhibitor (TKI) drugs, the accurate diagnosis of GIST has become imperative. The problem is that some GISTs with KIT or Alpha-type platelet-derived growth factor receptor (PDGFRA) mutations may have low KIT expression by immunohistochemistry yet will still benefit from TKI drugs. Molecular analysis is a costly and laborious process. Therefore the emergence of a new sensitive immunohistochemical marker for GISTs would be ideal. Recently antibodies against D iscovered on GIST-1 ( DOG1) have been generated. The aim of this study was to evaluate the monoclonal DOG1.1 antibody as a diagnostic marker for GISTs and to compare immunohistochemical staining and diagnostic efficacy of DOG1.1 with that of KIT in GISTs. Materials and Methods: Forty seven paraffin embedded GISTs were immuno stained with both Kit and DOG1.1 antibodies. Immunoreactivity was graded semiquantitatively from 0 to 4. Some other mesenchymal tumors were included in the study and stained for both markers to test for their specificity. Results: Out of the 47 GISTs, 44 were immunoreactive for both KIT and DOG1.1 antibodies (93.62%). Two cases (4.25%) were KIT-positive DOG-negative and the remaining case was DOG-positive KIT-negative (2.13%). A statistically significant concordance was found between KIT and DOG1.1 immunoreactivity (p=0.004), with moderate agreement between immunostaining scores (kappa =0.379). As regards tumor site, a statistically significant association was found between high DOG1.1 scores and gastric GIST (p=0.008). High KIT and DOG1.1 immunostaining scores were significantly associated with high risk tumors (p=0.002 and p=0.002 respectively). DOG1.1 immunoreactivity was focal in more than half of the cases. The overall diagnostic accuracy of DOG1.1 was 96.5%, with a specificity and

  17. Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression

    International Nuclear Information System (INIS)

    Ostrowski, Jerzy; Dobosz, Anna Jerzak Vel; Jarosz, Dorota; Ruka, Wlodzimierz; Wyrwicz, Lucjan S; Polkowski, Marcin; Paziewska, Agnieszka; Skrzypczak, Magdalena; Goryca, Krzysztof; Rubel, Tymon; Kokoszyñska, Katarzyna; Rutkowski, Piotr; Nowecki, Zbigniew I

    2009-01-01

    Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event through similar pathways, two previous studies reported the mutation-specific gene expression profiles. However, their further conclusions were rather discordant. To clarify the molecular characteristics of differentially expressed genes according to GIST receptor mutations, we combined microarray-based analysis with detailed functional annotations. Total RNA was isolated from 29 frozen gastric GISTs and processed for hybridization on GENECHIP ® HG-U133 Plus 2.0 microarrays (Affymetrix). KIT and PDGFRA were analyzed by sequencing, while related mRNA levels were analyzed by quantitative RT-PCR. Fifteen and eleven tumours possessed mutations in KIT and PDGFRA, respectively; no mutation was found in three tumours. Gene expression analysis identified no discriminative profiles associated with clinical or pathological parameters, even though expression of hundreds of genes differentiated tumour receptor mutation and expression status. Functional features of genes differentially expressed between the two groups of GISTs suggested alterations in angiogenesis and G-protein-related and calcium signalling. Our study has identified novel molecular elements likely to be involved in receptor-dependent GIST development and allowed confirmation of previously published results. These elements may be potential therapeutic targets and novel markers of KIT mutation status

  18. Risk perception and communication in vaccination decisions: a fuzzy-trace theory approach.

    Science.gov (United States)

    Reyna, Valerie F

    2012-05-28

    The tenets of fuzzy-trace theory, along with prior research on risk perception and risk communication, are used to develop a process model of vaccination decisions in the era of Web 2.0. The theory characterizes these decisions in terms of background knowledge, dual mental representations (verbatim and gist), retrieval of values, and application of values to representations in context. Lack of knowledge interferes with the ability to extract the essential meaning, or gist, of vaccination messages. Prevention decisions have, by definition, a status quo option of "feeling okay." Psychological evidence from other prevention decisions, such as cancer screening, indicates that many people initially mentally represent their decision options in terms of simple, categorical gist: a choice between (a) a feeling-okay option (e.g., the unvaccinated status quo) versus (b) taking up preventive behavior that can have two potential categorical outcomes: feeling okay or not feeling okay. Hence, applying the same theoretical rules as used to explain framing effects and the Allais paradox, the decision to get a flu shot, for example, boils down to feeling okay (not sick) versus feeling okay (not sick) or not feeling okay (sick, side effects, or death). Because feeling okay is superior to not feeling okay (a retrieved value), this impoverished gist supports choosing not to have the flu vaccine. Anti-vaccination sources provide more coherent accounts of the gist of vaccination than official sources, filling a need to understand rare adverse outcomes. Copyright © 2011 Elsevier Ltd. All rights reserved.

  19. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry.

    Science.gov (United States)

    Call, Jerry; Walentas, Christopher D; Eickhoff, Jens C; Scherzer, Norman

    2012-03-19

    Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations) and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies) types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P diligence be taken with "young adults" (aged 18-35 at diagnosis) as pediatric-type GIST may present well beyond adolescence, particularly as these distinct sub-types have different causes, and consequently respond differently to treatments.

  20. The safety of regorafenib for the treatment of gastrointestinal stromal tumors.

    Science.gov (United States)

    Rutkowski, Piotr; Stępniak, Joanna

    2016-01-01

    The management of gastrointestinal stromal tumors (GIST) evolved due to effective molecularly targeted therapy with imatinib and sunitinib which are used first- and second-line, respectively. However, due to the development of resistance to those drugs in the majority of patients, the need for third-line therapy arose. Regorafenib, an oral multitargeted inhibitor with activity against multiple kinases including KIT, RET, RAF1, BRAF, angiogenesis (VEGFR, TIE-2) and those involved in tumor microenvironment (PDGFR and FGFR) was introduced after the successful Phase III GRID (GIST - Regorafenib In progressive Disease) clinical trial. This study showed significant improvement in progression-free survival for patients receiving regorafenib compared to placebo (4.8 months vs 0.9 months). The treatment was reasonably well tolerated, with arterial hypertension, hand-foot syndrome, diarrhea being the most common grade ≥3 adverse events, which could be managed by dose reduction and supportive treatment. The aim of this paper is to describe, assess and advise on the safety of regorafenib as third-line therapy in GIST. Regorafenib has demonstrated clinical benefit in GIST patients after progression on prior treatment with at least imatinib/sunitinib and currently it is the approved standard third-line option in therapy of advanced GIST. The safety profile is similar to other multikinase inhibitors with anti-VEGFR activity and is manageable.

  1. The value of (18) F-fluorodeoxyglucose positron emission tomography for prediction of treatment response in gastrointestinal stromal tumors: a systematic review and meta-analysis.

    Science.gov (United States)

    Hassanzadeh-Rad, Arman; Yousefifard, Mahmoud; Katal, Sanaz; Asady, Hadi; Fard-Esfahani, Armaghan; Moghadas Jafari, Ali; Hosseini, Mostafa

    2016-05-01

    Early detection of response to treatment is critically important in gastrointestinal stromal tumors (GIST). Therefore, the present systematic review and meta-analysis assessed the value of (18) f-fluorodeoxyglucose positron emission tomography ((18) FDG-PET) on prediction of therapeutic response of GIST patients to systemic treatments. The literature search was conducted using PubMed, SCOPUS, Cochrane, and Google Scholar databases, and review article references. Eligible articles were defined as studies included confirmed GIST patients who underwent (18) FDG-PET as well as assessing the screening role of it. Finally, 21 relevant articles were included. The analysis showed the pooled sensitivity and specificity of 18FDG-PET in evaluation of response to treatment of GIST patient were 0.90 (95% CI: 0.85-0.94; I(2)  = 52.59, P = 0.001) and 0.62 (95% CI: 0.49-0.75; I(2)  = 69.7, P = 0.001), respectively. In addition, the pooled prognostic odds ratio of (18) FDG-PET for was 14.99 (95% CI, 6.42-34.99; I(2)  = 100.0, P present meta-analysis showed (18) FDG-PET has a significant value in predicting treatment response in GIST patients. © 2015 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

  2. Gastrointestinal stromal tumors: retrospective analysis of the computer-tomographic aspects.

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    Lupescu, Ioana G; Grasu, Mugur; Boros, Mirela; Gheorghe, Cristian; Ionescu, Mihnea; Popescu, Irinel; Herlea, Vlad; Georgescu, Serban A

    2007-06-01

    To describe the computer-tomographic (CT) aspects of gastrointestinal stromal tumors (GISTs) in correlation to their histology. The medical records of all patients at our hospital with a histologic diagnosis of GIST between January 2002 and June 2006, and investigated before surgery by CT, were reviewed. Two radiologists with knowledge of the diagnosis reviewed the CT findings. Amongst 15 cases of GISTs, 9 cases involved the stomach and 4 cases the small intestine. Location of the primary tumor could not be determined for 2 of 15 tumors, because of the presence of extensive peritoneal metastases. Most primary tumors were predominantly extraluminal (13 cases) while two were clearly endoluminal. The mean diameter of the primary tumor was 8 cm. The tumor margin was well defined in 12 patients and irregular in 3 cases. Central fluid attenuation was present in 11 tumors, while central gas was seen in two cases. Metastases were seen in 2 cases at presentation and in another 2 patients during follow-up. Spread was exclusive to the liver or peritoneum. Visceral obstruction was absent even in extensive peritoneal metastatic disease. Ascites was an unusual finding. CT plays an important role not only in the detection and the localization but also in the evaluation of the extension and follow-up of theses tumors. Using only CT aspects, we can only suspect the diagnosis to GISTs. Often other soft-tissue tumors with gastrointestinal involvement can mimic GISTs. In all cases histological diagnosis is essential.

  3. Multicentric malignant gastrointestinal stromal tumor

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    Shukla, Shailaja; Singh, Sanjeet K; Pujani, Mukta

    2009-01-01

    Malignant gastrointestinal stromal tumor (GIST) is a rare type of sarcoma that is found in the digestive system, most often in the wall of the stomach. Multiple GISTs are extremely rare and usually associated with type 1 neurofibromatosis and familial GIST. We report here a case of a 70-year-old woman who reported pain in the abdomen, loss of appetite, and weight loss for six months. Ultrasound examination showed a small bowel mass along with multiple peritoneal deposits and a mass within the liver. Barium studies were suggestive of a neoplastic pathology of the distal ileum. A differential diagnosis of adenocarcinoma/lymphoma with metastases was entertained. Perioperative findings showed two large growths arising from the jejunum and the distal ileum, along with multiple smaller nodules on the serosal surface and adjoining mesentery of the involved bowel segments. Segmental resection of the involved portions of the intestine was performed. Histopathological features were consistent with those of multicentric malignant GIST-not otherwise specified (GIST-NOS). Follow-up examination three months after surgery showed no evidence of recurrence. (author)

  4. [Radical Resection of Huge Gastrointestinal Stromal Tumor of the Stomach Following Neoadjuvant Chemotherapy with lmatinib - ACase Report].

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    Hiraki, Yoko; Kato, Hiroaki; Shiraishi, Osamu; Tanaka, Yumiko; Iwama, Mitsuru; Yasuda, Atsushi; Shinkai, Masayuki; Kimura, Yutaka; Imano, Motohiro; Imamoto, Haruhiko; Yasuda, Takushi

    2017-11-01

    The usefulness and safety of imatinibfor neoadjuvant chemotherapy for resectable gastrointestinal stromal tumor(GIST) has not been established. We reported a case of a huge GIST of the stomach that was safely resected following preoperative imatinibtherapy. A 69-year-old man was hospitalized with abdominal fullness which increased rapidly from a month ago. A CT scan showed a huge tumor containing solid and cystic component which was accompanied by an extra-wall nodule. The tumor was strongly suspected to be originated from the stomach and EUS-FNA revealed GIST. We diagnosed GIST of the stomach and initiated preoperative adjuvant chemotherapy with imatinib because there was a risk for the break of tumor capsule and composite resection of the other organs without prior chemotherapy. After the administration of imatinib4 00 mg/day for 6months, the solid component was decreased in size and its' activity by PET-CT had declined, but the size of the cystic component was not changed and the patient's complaint of fullness was not reduced. Then, after a week cessation of imatinib, we performed surgical removal of the tumor with partial gastrectomy without surgical complication during and after the operation. Imatinibwas resumed 2 weeks later postoperatively and 1 year and 8 months has passed since the operation without recurrence. Neoadjuvant chemotherapy with imatinibhas the potential to become an important therapeutic option for the treatment of huge GISTs.

  5. miRNA-218-loaded carboxymethyl chitosan - Tocopherol nanoparticle to suppress the proliferation of gastrointestinal stromal tumor growth

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    Tu, Lin; Wang, Ming; Zhao, Wen-Yi; Zhang, Zi-Zhen; Tang, De-Feng; Zhang, Ye-Qian [Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127 (China); Cao, Hui, E-mail: caohui10281@163.com [Department of Gastrointestinal Surgery, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127 (China); Zhang, Zhi-Gang, E-mail: zhangzhiganggz@hotmail.com [State Key Laboratory for Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240 (China)

    2017-03-01

    Gastrointestinal stromal tumors (GIST) are one of the most common forms of mesenchymal cancers of the gastrointestinal tract. Although chemotherapeutic drugs inhibited the proliferation of GIST, however, sizable proportion of people developed resistance and therefore difficult to treat. In the present study, O-carboxymethyl chitosan (OCMC)-tocopherol polymer conjugate was synthesized and formulated into stable polymeric nanoparticles. The main aim of present study was to increase the therapeutic efficacy of miR-218 in GIST. The mean size of nanoparticles was ~ 110 nm with a spherical shape. The miR-218 NP has been shown inhibit the cell proliferation and exhibited a superior cell apoptosis. The miR-218 NP inhibited the cell invasion and promoted the apoptosis of GIST cancer cells. In the present study, we have successfully showed that KIT1 is the target gene of miR-218 as shown by the luciferase reporter assay. These findings collectively suggest the miR-218 loaded nanoparticle by virtue of effective transfection could act as a tumor suppressor miRNA in the treatment of GIST. - Highlights: • O-carboxymethyl chitosan (OCMC)-tocopherol polymer conjugate was synthesized and formulated in nanoparticles. • The miR-218 NP has been shown inhibit the cell proliferation and exhibited a superior cell apoptosis. • We have successfully showed that KIT1 is the target gene of miR-218 as shown by the luciferase reporter assay.

  6. How can survival processing improve memory encoding?

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    Luo, Meng; Geng, Haiyan

    2013-11-01

    We investigated the psychological mechanism of survival processing advantage from the perspective of false memory in two experiments. Using a DRM paradigm in combination with analysis based on signal detection theory, we were able to separately examine participants' utilization of verbatim representation and gist representation. Specifically, in Experiment 1, participants rated semantically related words in a survival scenario for a survival condition but rated pleasantness of words in the same DRM lists for a non-survival control condition. The results showed that participants demonstrated more gist processing in the survival condition than in the pleasantness condition; however, the degree of item-specific processing in the two encoding conditions did not significantly differ. In Experiment 2, the control task was changed to a category rating task, in which participants were asked to make category ratings of words in the category lists. We found that the survival condition involved more item-specific processing than did the category condition, but we found no significant difference between the two encoding conditions at the level of gist processing. Overall, our study demonstrates that survival processing can simultaneously promote gist and item-specific representations. When the control tasks only promoted either item-specific representation or gist representation, memory advantages of survival processing occurred.

  7. Duodenal Wedge Resection for Large Gastrointestinal Stromal Tumour Presenting with Life-Threatening Haemorrhage

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    Alexander Shaw

    2013-01-01

    Full Text Available Background. Duodenal gastrointestinal stromal tumours (GISTs are an uncommon malignancy of the gastrointestinal (GI tract. We present a case of life-threatening haemorrhage caused by a large ulcerating duodenal GIST arising from the third part of the duodenum managed by a limited duodenal wedge resection. Case Presentation. A 61-year-old patient presented with acute life-threatening gastrointestinal bleeding. After oesophagogastroduodenoscopy failed to demonstrate the source of bleeding, a 5 cm ulcerating exophytic mass originating from the third part of the duodenum was identified at laparotomy. A successful limited wedge resection of the tumour mass was performed. Histopathology subsequently confirmed a duodenal GIST. The patient remained well at 12-month followup with no evidence of local recurrence or metastatic spread. Conclusion. Duodenal GISTs can present with life-threatening upper GI haemorrhage. In the context of acute haemorrhage, even relatively large duodenal GISTs can be treated by limited wedge resection. This is a preferable alternative to duodenopancreatectomy with lower morbidity and mortality but comparable oncological outcome.

  8. Three cases of bone metastases in patients with gastrointestinal stromal tumors

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    Maurizio Zompatori

    2011-04-01

    Full Text Available Gastrointestinal stromal tumors (GISTs are rare, but represent the most common mesenchymal neoplasms of the gastrointestinal tract. Tumor resection is the treatment of choice for localized disease. Tyrosine kinase inhibitors (imatinib, sunitinib are the standard therapy for metastatic or unresectable GISTs. GISTs usually metastasize to the liver and peritoneum. Bone metastases are uncommon. We describe three cases of bone metastases in patients with advanced GISTs: two women (82 and 54 years of age, and one man (62 years of age. Bones metastases involved the spine, pelvis and ribs in one patient, multiple vertebral bodies and pelvis in one, and the spine and iliac wings in the third case. The lesions presented a lytic pattern in all cases. Two patients presented with multiple bone metastases at the time of initial diagnosis and one patient after seven years during the follow-up period. This report describes the diagnosis and treatment of the lesions and may help clinicians to manage bones metastases in GIST patients.

  9. Pancreatic Gastrointestinal Stromal Tumor after Upper Gastrointestinal Hemorrhage and Performance of Whipple Procedure: A Case Report and Literature Review.

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    Aziret, Mehmet; Çetinkünar, Süleyman; Aktaş, Elife; İrkörücü, Oktay; Bali, İlhan; Erdem, Hasan

    2015-08-03

    Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the gastrointestinal system. These types of tumors originate from any part of the tract as well as from the intestine, colon, omentum, mesentery or retroperitoneum. GIST is a rare tumor compared to other types of tumors, accounting for less than 1% of all gastrointestinal tumors. A 56-year-old male patient was hospitalized due to an upper gastrointestinal hemorrhage and the start of abdominal pain on the same day. In the upper gastrointestinal endoscopy that was performed, a solitary mass was found in the second section of the duodenum and a blood vessel (Forrest type 2a) was seen. The extent and location of the mass was detected by abdominal tomography. After hemodynamic recovery, a Whipple procedure was performed without any complications. A subsequent histopathological examination detected a c-kit-positive (CD117) pancreatic GIST with high mitotic index. The most effective treatment method for GISTs is surgical resection. In patients with a head of pancreatic GIST, the Whipple procedure can be used more safely and effectively.

  10. Distrofia de Schnyder

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    Zaadia Pérez Parra

    Full Text Available Entre las distrofias estromales encontramos la distrofia de Schnyder, que se caracteriza por ser bilateral y progresiva. Su diagnóstico es relativamente sencillo cuando se presenta con cristales de colesterol y fosfolípidos. El estudio histológico y la microscopia confocal confirman el diagnóstico. Presentamos dos casos clínicos de distrofia de Schnyder, en pacientes del sexo femenino, quienes acudieron a la consulta y refirieron disminución de la visión y cambio de coloración de los ojos. Los hallazgos clínicos y la microscopia confocal confirman el diagnóstico de distrofia de Schnyder, la cual se caracteriza por la presencia de cristales en el estroma anterior central de distribución anular o disciforme, asociado a arco lipoide y haze en la media periferia. La fotoqueratectomía con excímer láser cuando la afección se limita al estroma anterior, o la queratoplastia penetrante en casos más avanzados, constituyen el arsenal terapéutico en esta afección.

  11. Modificaciones de la curvatura posterior corneal después de la cirugía refractiva láser Modifications in the corneal posterior curve after laser refractive surgery

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    Lorelei Ortega Díaz

    2011-06-01

    Full Text Available OBJETIVO: Describir las modificaciones de la curvatura posterior corneal en pacientes sometidos a cirugía refractiva láser en el Instituto Cubano de Oftalmología "Ramón Pando Ferrer" en el período de mayo a octubre de 2010. MÉTODOS: Se realizó un estudio descriptivo, longitudinal y prospectivo, con un universo de 257 pacientes (504 ojos sometidos a cirugía refractiva láser. La muestra quedó conformada por 31 pacientes (59 ojos. Se analizaron variables como edad, sexo, equivalente esférico, paquimetría preoperatoria, cantidad de ablación, estroma residual y diferencia de elevación posterior corneal, esta última obtenida del mapa de diferencia del topógrafo Galilei, con medición preoperatoria al mes y a los tres meses de la cirugía. Mediante análisis de regresión múltiple fueron valorados dichos cambios de la paquimetría, la cantidad de ablación y el estroma residual. RESULTADOS: El equivalente esférico, la paquimetría, la cantidad de ablación y el estroma residual se encontraron dentro de los parámetros de seguridad establecidos. La diferencia promedio de la elevación corneal posterior fue de 15,62 µm al mes y de 11,78 µm a los tres meses, con disminución significativa con el tiempo (p= 0,000. Se observó asociación con la paquimetría preoperatoria y el estroma residual, y se encontró una correlación inversa entre este último y la elevación corneal posterior a los tres meses. CONCLUSIONES: La cirugía refractiva láser induce un aumento precoz en la elevación corneal posterior, con disminución progresiva hacia el tercer mes. Los factores que más influyeron en estos cambios fueron el estroma residual y la paquimetría preoperatoria.OBJECTIVES: To describe the modifications in the corneal posterior curve in patients underwent laser refractive surgery in the "Ramón Pando Ferrer" Cuban Institute of Ophthalmology from May to October, 2020. METHODS: A prospective, longitudinal and descriptive study was conducted

  12. Gastrointestinal tract spindle cell lesions--just like real estate, it's all about location.

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    Voltaggio, Lysandra; Montgomery, Elizabeth A

    2015-01-01

    Interpretation of gastrointestinal tract mesenchymal lesions is simplified merely by knowing in which anatomic layer they are usually found. For example, Kaposi sarcoma is detected on mucosal biopsies, whereas inflammatory fibroid polyp is nearly always in the submucosa. Gastrointestinal stromal tumors (GISTs) are generally centered in the muscularis propria. Schwannomas are essentially always in the muscularis propria. Mesenteric lesions are usually found in the small bowel mesentery. Knowledge of the favored layer is even most important in interpreting colon biopsies, as many mesenschymal polyps are encountered in the colon. Although GISTs are among the most common mesenchymal lesions, we will concentrate our discussion on other mesenchymal lesions, some of which are in the differential diagnosis of GIST, and point out some diagnostic pitfalls, particularly in immunolabeling.

  13. Spontaneous Rupture of Recurrent Gastrointestinal Stromal Tumor Associated with Neurofibromatosis Type 1

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    Shin-Mae Wang

    2005-11-01

    Full Text Available The incidence of gastrointestinal stromal tumor (GIST among neurofibromatosis type 1 (NF-1 patients is approximately 3.9–25%, and this relationship is generally considered to be non-coincidental. We report a patient with NF-1 who underwent laparotomy 3 times due to recurrent intra-abdominal tumor rupture with internal bleeding in the space of 13 years. The pathologic diagnoses were schwannoma, malignant peripheral nerve sheath tumor and GIST. Because of the similar histologic features of these tumors, we considered them to be of the same nature. Immunohistochemical staining can help in the differential diagnosis. We suggest that NF-1 patients with gastrointestinal symptoms receive further survey to rule out GISTs.

  14. Management of hemorrhage in gastrointestinal stromal tumors: a review.

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    Liu, Qi; Kong, Fanmin; Zhou, Jianping; Dong, Ming; Dong, Qi

    2018-01-01

    Gastrointestinal stromal tumors (GISTs) are relatively common mesenchymal tumors. They originate from the wall of hollow viscera and may be found in any part of the digestive tract. The prognosis of patients with stromal tumors depends on various risk factors, including size, location, presence of mitotic figures, and tumor rupture. Emergency surgery is often required for stromal tumors with hemorrhage. The current literature suggests that stromal tumor hemorrhage indicates poor prognosis. Although the optimal treatment options for hemorrhagic GISTs are based on surgical experience, there remains controversy with regard to optimum postoperative management as well as the classification of malignant potential. This article reviews the biological characteristics, diagnostic features, prognostic factors, treatment, and postoperative management of GISTs with hemorrhage.

  15. Laparoscopic resection of gastric gastrointestinal stromal tumors presenting as left adrenal tumors

    Institute of Scientific and Technical Information of China (English)

    Shiu-Dong Chung; Jeff Shih-chieh Chueh; Hong-Jeng Yu

    2012-01-01

    Gastrointestinal stromal tumors (GISTs) are rare gastrointestinal malignancies. They are rarely seen near the urinary tract. In a literature review, only one case of GIST presenting as a left adrenal tumor was reported. We report two documented cases of gastric GISTs mimicking left adrenal tumors which were successfully treated with pure laparoscopic adrenalectomy and wedge resection of the stomach by excising the tumor from the stomach with serial firing of endoscopic gastrointestinal staplers. The surgical margins were clear, and the patients recovered smoothly. No adjuvant therapy with imatinib was prescribed. During the surveillance for 9 mo and 44 mo respectively, no tumor recurrence and metastasis were documented. Laparoscopic tumor excision, when adhering to the principles of surgical oncology, seems feasible and the prognosis is favorable for such tumors.

  16. Fibromatosis of the Sigmoid Colon With CTNNB1 (β-Catenin) Gene Mutation, Arising at the Site of Ileocolic Anastomosis for Resection of Gastrointestinal Stromal Tumor.

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    Thway, Khin; Abou Sherif, Sara; Riddell, Angela M; Mudan, Satvinder

    2016-05-01

    We describe a case of intra-abdominal fibromatosis, which occurred in a 44-year-old woman who had a previous history of gastrointestinal stromal tumor (GIST) of the sigmoid mesocolon, which was treated with imatinib and resection. A mass was detected at the site of ileocolic anastomosis of the previous small bowel resection and sigmoid colectomy, nearly 3 years later. Clinically, this was suspected to represent recurrent GIST and was excised, but histology and mutational analysis showed desmoid-type fibromatosis with a mutation in codon 41 of exon 3 of the CTNNB1 (β-catenin) gene. The occurrence of fibromatosis at the site of excision of GIST is very rare, but its recognition is important as the treatment of the two neoplasms differs significantly. As imaging cannot reliably distinguish between these 2 entities, histological diagnosis is crucial for correct clinical management. © The Author(s) 2015.

  17. Spontaneous rupture of pedunculate gastric gastrointestinal stromal tumor into the gastrocelic ligament presenting as a stalked mass surrounded by loculated hematoma

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    Kim, Hyun Soo; Ahn, Sung Eun; Park, Seong Jin; Moon, Sung Kyoung; Lim, Joo Won; Lee, Dong Ho; Kim, Yong Ho [Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul (Korea, Republic of)

    2015-04-15

    Gastric gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors of the stomach, which may be asymptomatic or cause symptoms such as pain, gastrointestinal bleeding, and obstruction. Hemoperitoneum due to spontaneous rupture of the tumor is an extremely rare complication. We described a case of a 52-year-old man with a large pedunculated GIST causing loculated hematoma within the gastrocolic ligament. The patient visited our hospital due to a 3 week history of epigastric pain. A computed tomography scan revealed a 10.3 x 7.5 x 9.4 cm sized mass that was growing exophytically from the greater curvature of the stomach and was surrounded by loculated hematoma within the gastrocolic ligament. Laparotomy revealed a large stalked gastric mass surrounded by loculated hematoma within the gastrocolic ligament and blood fluid in the peritoneal cavity. Pathologic examination confirmed a GIST, of the high risk group.

  18. Tumor estromal gastrointestinal de intestino delgado

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    Francisco Marivaldo Benício da Silva

    Full Text Available Stromal tumors of the gastrointestinal tract (gists represent relatively rare lesions that arise from connective tissue elements located along the entire length of the gut. They were initially identified by immunohistochemical investigation, proving their origin from nondifferentiated mesenchymal cells. Only a minority of this lesions, mainly those confined to the esophagus and rectum, have been shown to correspond to mature, well-differentiated types of neoplasms such as leiomyoma or leiomyosarcoma. The majority of gists corresponds to a heterogeneous group of lesions that have as their common denominator an immature proliferation of epithelioid or spindle cells arising from its muscle layers, or between them, showing partial or incomplete myoide, neural, ganglionic, or mixed features of differentiation. This case report intends to show a gist of small bowel in a male, 46 years old, with a two-year of evolution.

  19. Necrotizing enterocolitis, pathogenesis and the protector effect of prenatal corticosteroids Enterocolite necrosante: resposta imflamatória x corticoterapia pré-natal

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    Alexander Roberto Precioso

    2002-09-01

    Full Text Available Necrotizing enterocolitis is the most frequently occurring gastrointestinal disorder in premature neonates. Animal models of necrotizing enterocolitis and prenatal administration of cortisone have demonstrated that cortisone may accelerate maturation of the mucosal barrier, therefore reducing the incidence of this gastrointestinal disorder. The authors present a review of the literature of the most important risk factors associated with necrotizing enterocolitis, such as inflammatory gastrointestinal mediators, enteral feeding and bacterial colonization, and immaturity of the gastrointestinal barrier, and we emphasize the necessity for additional studies to explore the prenatal administration of cortisone as a preventive strategy for necrotizing enterocolitis.A enterocolite necrosante é a mais freqüente patologia gastrointestinal adquirida no período neonatal, acometendo preferencialmente o recém-nascido prematuro. Estudos experimentais sugerem que a corticoterapia pré-natal acelera a maturação da mucosa gastrintestinal, levando a diminuição da incidência desta doença. Os autores apresentam uma revisão da literatura em relação aos principais fatores fisiopatológicos associados a enterocolite necrosante, tais como mediadores inflamatórios gastrintestinais, nutrição enteral e colonização bacteriana e imaturidade gastrintestinal e enfatizam a necessidade de mais estudos que avaliem a influencia da corticoterapia pré-natal com fator de prevenção da enterocolite necrosante.

  20. Leiomyomas in the gastric cardia: CT findings and differentiation from gastrointestinal stromal tumors

    International Nuclear Information System (INIS)

    Yang, Hyun Kyung; Kim, Young Hoon; Lee, Yoon Jin; Park, Ji Hoon; Kim, Ji Young; Lee, Kyoung Ho; Lee, Hye Seung

    2015-01-01

    Highlights: • Gastric leiomyomas frequently involve the gastric cardia. • Gastric cardial leiomyomas and GISTs could be differentiated with CT. • Differentiation of cardial leiomyomas and GISTs can help choosing surgical procedure. - Abstract: Objective: To describe CT findings of leiomyomas and gastrointestinal stromal tumors (GISTs) in the gastric cardia and to identify their differentiating features. Materials and methods: CT images of pathologically proven leiomyomas (n = 26) and GISTs (n = 19) in the gastric cardia were retrospectively reviewed for esophagogastric junction (EGJ) involvement, contour, surface, growth pattern, enhancement pattern and degree of the tumor, and the presences of intralesional low attenuation, calcification and surface dimples or ulcers. The long (LD) and short diameters (SD), LD/SD ratio, and attenuation value of each lesion were measured. Results: EGJ involvement, homogeneous enhancement, intermediate or low enhancement, absences of intralesional low attenuation and surface dimples or ulcers, LD/SD ratio >1.2, and attenuation value ≤71.2 HU were significant findings for differentiating leiomyomas from GISTs (P < 0.05 for each finding). An LD/SD ratio of >1.2 and attenuation value of ≤71.2 HU yielded sensitivities of 84.6% and 61.5%, and specificities of 52.6% and 84.2%, respectively, on the receiver operating characteristic curve analysis. When at least five of these seven criteria were used in combination, the sensitivity and specificity for diagnosing leiomyomas were 100% (26 of 26) and 89.5% (17 of 19), respectively. When any six of these criteria were used, a specificity of 100% was achieved. Conclusions: CT features including EGJ involvement, enhancement pattern and degree, presences of intralesional low attenuation and surface dimples or ulcers, LD/SD ratio, and attenuation value could help differentiating leiomyomas from GISTs in the gastric cardia, particularly in the manner of combination

  1. Downsizing Treatment with Tyrosine Kinase Inhibitors in Patients with Advanced Gastrointestinal Stromal Tumors Improved Resectability

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    Sjölund, Katarina; Andersson, Anna; Nilsson, Erik; Nilsson, Ola; Ahlman, Håkan

    2010-01-01

    Background Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase KIT. Most GISTs have mutations in the KIT or PDGFRA gene, causing activation of tyrosine kinase. Imatinib, a tyrosine kinase inhibitor (TKI), is the first-line palliative treatment for advanced GISTs. Sunitinib was introduced for patients with mutations not responsive to imatinib. The aim was to compare the survival of patients with high-risk resected GISTs treated with TKI prior to surgery with historical controls and to determine if organ-preserving surgery was facilitated. Methods Ten high-risk GIST-patients had downsizing/adjuvant TKI treatment: nine with imatinib and one with sunitinib. The patients were matched with historical controls (n = 89) treated with surgery alone, from our population-based series (n = 259). Mutational analysis of KIT and PDGFRA was performed in all cases. The progression-free survival was calculated. Results The primary tumors decreased in mean diameter from 20.4 cm to 10.5 cm on downsizing imatinib. Four patients with R0 resection and a period of adjuvant imatinib had no recurrences versus 67% in the historical control group. Four patients with residual liver metastases have stable disease on continuous imatinib treatment after surgery. One patient has undergone reoperation with liver resection. The downsizing treatment led to organ-preserving surgery in nine patients and improved preoperative nutritional status in one patient. Conclusions Downsizing TKI is recommended for patients with bulky tumors with invasion of adjacent organs. Sunitinib can be used for patients in case of imatinib resistance (e.g., wild-type GISTs), underlining the importance of mutational analysis for optimal surgical planning. PMID:20512492

  2. Prognostic Factors of Patients with Gastric Gastrointestinal Stromal Tumor after Curative Resection: A Retrospective Analysis of 406 Consecutive Cases in a Multicenter Study.

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    Kim, In-Hwan; Kwak, Sang-Gyu; Chae, Hyun-Dong

    2015-01-01

    Gastric gastrointestinal stromal tumors (GISTs) have a highly variable clinical course, and recurrent disease sometimes develops despite curative surgery. This study was undertaken to investigate the surgical role in treating gastric GISTs and evaluate the clinicopathological features of a large series of patients who underwent curative resection for gastric GISTs to clarify which features were independent prognostic factors. The clinicopathological data of 406 patients with gastric GISTs who underwent curative resection at 4 university hospitals in Daegu, South Korea, from March 1998 to March 2012 were reviewed. All cases were confirmed as gastric GISTs by immunohistochemical staining, in which CD117 or CD34 was positive. Clinical follow-up was performed periodically, and disease-free survival rates were retrospectively investigated using the medical records. The mean follow-up period was 42.9 months (range: 2-166). There were 11 recurrent patients (2.7%). Due to the small number of recurrences, age, sex and location were controlled using propensity score matching before performing any statistical analysis. Tumor size, mitotic count, NIH classification, and cellularity were judged to be independent prognostic factors for recurrence by univariate analysis. In a multivariate analysis, tumor size and mitotic count were significantly and independently related to recurrence, and tumor size was determined to be the most important prognostic factor for recurrence after curative resection (hazard ratio: 1.204; p < 0.01). The results of this multicenter study demonstrate that disease-free survival rates are good. Tumor size was disclosed as the most important factor for recurrence in gastric GIST patients who underwent radical resection. 2015 S. Karger AG, Basel.

  3. Mutational profile of KIT and PDGFRA genes in gastrointestinal stromal tumors in Peruvian samples

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    José Buleje

    2015-02-01

    Full Text Available Introduction: Gastrointestinal stromal tumors (GISTs are mesenchymal neoplasms usually caused by somatic mutations in the genes KIT (c-KIT or PDGFRA. Mutation characterization has become an important exam for GIST patients because it is useful in predicting the response to the inhibitors of receptor tyrosine kinase (RTK. Objectives: The aim of this study was to determine the frequency of KIT and PDGFRA mutations in 25 GIST samples collected over two years at two national reference hospitals in Peru. There were 21 samples collected from the Instituto Nacional de Enfermedades Neoplásicas (INEN, national cancer center and 4 samples collected from Hospital A. Loayza. Methods and materials: In this retrospective study, we performed polymerase chain reaction (PCR amplification and deoxyribonucleic acid (DNA sequencing of KIT (exons 9, 11, 13, and 17 and PDGFRA (exons 12 and 18 genes in 20 FFPE (formalin-fixed, paraffin-embedded and 5 frozen GIST samples. Results: We report 21 mutations, including deletions, duplications, and missense, no mutations in 2 samples, and 2 samples with no useful DNA for further analysis. Eighty-six percent of these mutations were located in exon 11 of KIT, and 14 % were located in exon 18 of PDGFRA. Conclusions: Our study identified mutations in 21 out of 25 GIST samples from 2 referential national hospitals in Peru, and the mutation proportion follows a global tendency observed from previous studies (i.e., the majority of samples presented KIT mutations followed by a minor percentage of PDGFRA mutations. This study presents the first mutation data of the KIT and PDGFRA genes from Peruvian individuals with GIST.

  4. Leiomyomas in the gastric cardia: CT findings and differentiation from gastrointestinal stromal tumors

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Hyun Kyung [Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707 (Korea, Republic of); Kim, Young Hoon, E-mail: yhkrad@gmail.com [Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707 (Korea, Republic of); Lee, Yoon Jin; Park, Ji Hoon; Kim, Ji Young; Lee, Kyoung Ho [Department of Radiology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Institute of Radiation Medicine, Seoul National University Medical Research Center, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707 (Korea, Republic of); Lee, Hye Seung [Department of Pathology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-si, Gyeonggi-do 463-707 (Korea, Republic of)

    2015-09-15

    Highlights: • Gastric leiomyomas frequently involve the gastric cardia. • Gastric cardial leiomyomas and GISTs could be differentiated with CT. • Differentiation of cardial leiomyomas and GISTs can help choosing surgical procedure. - Abstract: Objective: To describe CT findings of leiomyomas and gastrointestinal stromal tumors (GISTs) in the gastric cardia and to identify their differentiating features. Materials and methods: CT images of pathologically proven leiomyomas (n = 26) and GISTs (n = 19) in the gastric cardia were retrospectively reviewed for esophagogastric junction (EGJ) involvement, contour, surface, growth pattern, enhancement pattern and degree of the tumor, and the presences of intralesional low attenuation, calcification and surface dimples or ulcers. The long (LD) and short diameters (SD), LD/SD ratio, and attenuation value of each lesion were measured. Results: EGJ involvement, homogeneous enhancement, intermediate or low enhancement, absences of intralesional low attenuation and surface dimples or ulcers, LD/SD ratio >1.2, and attenuation value ≤71.2 HU were significant findings for differentiating leiomyomas from GISTs (P < 0.05 for each finding). An LD/SD ratio of >1.2 and attenuation value of ≤71.2 HU yielded sensitivities of 84.6% and 61.5%, and specificities of 52.6% and 84.2%, respectively, on the receiver operating characteristic curve analysis. When at least five of these seven criteria were used in combination, the sensitivity and specificity for diagnosing leiomyomas were 100% (26 of 26) and 89.5% (17 of 19), respectively. When any six of these criteria were used, a specificity of 100% was achieved. Conclusions: CT features including EGJ involvement, enhancement pattern and degree, presences of intralesional low attenuation and surface dimples or ulcers, LD/SD ratio, and attenuation value could help differentiating leiomyomas from GISTs in the gastric cardia, particularly in the manner of combination.

  5. Visual search of Mooney faces

    Directory of Open Access Journals (Sweden)

    Jessica Emeline Goold

    2016-02-01

    Full Text Available Faces spontaneously capture attention. However, which special attributes of a face underlie this effect are unclear. To address this question, we investigate how gist information, specific visual properties and differing amounts of experience with faces affect the time required to detect a face. Three visual search experiments were conducted investigating the rapidness of human observers to detect Mooney face images. Mooney images are two-toned, ambiguous images. They were used in order to have stimuli that maintain gist information but limit low-level image properties. Results from the experiments show: 1 although upright Mooney faces were searched inefficiently, they were detected more rapidly than inverted Mooney face targets, demonstrating the important role of gist information in guiding attention towards a face. 2 Several specific Mooney face identities were searched efficiently while others were not, suggesting the involvement of specific visual properties in face detection. 3 By providing participants with unambiguous gray-scale versions of the Mooney face targets prior to the visual search task, the targets were detected significantly more efficiently, suggesting that prior experience with Mooney faces improves the ability to extract gist information for rapid face detection. However, a week of training with Mooney face categorization did not lead to even more efficient visual search of Mooney face targets. In summary, these results reveal that specific local image properties cannot account for how faces capture attention. On the other hand, gist information alone cannot account for how faces capture attention either. Prior experience facilitates the effect of gist on visual search of faces, making faces a special object category for guiding attention.

  6. Fluxo biológico do fósforo no metabolismo de suínos alimentados com dietas contendo fitase Biological P flow on metabolism of pigs fed diets containg phytase

    Directory of Open Access Journals (Sweden)

    José Aparecido Moreira

    2004-12-01

    Full Text Available A pesquisa foi conduzida para avaliar o fluxo biológico do P em suínos, na fase de crescimento, alimentados com dietas à base de milho, farelo de soja, farelo de arroz desengordurado e óleo de soja, isentas de P inorgânico e suplementadas com níveis crescentes de fitase (253, 759, 1.265 e 1.748 UF/kg de dieta, e destacar o melhor nível de utilização da enzima, usando modelos matemáticos. O modelo utilizado foi determinístico e compartimental, em que o trato gastrintestinal (C1, o plasma C2, os ossos (C3 e os tecidos moles (ossos, coração, figado, rins e músculos, estudados em conjunto (C4, representaram os compartimentos. Foram utilizados dados de metabolismo e cinética do P nos tecidos, obtidos pela técnica de diluição isotópica. Os parâmetros estimados foram: absorção, retenção, P endógeno que retorna ao trato gastrintestinal, P dietético absorvido, incorporação, reabsorção, balanço de P, P proveniente do osso, dos tecidos moles e do total absorvido que retorna ao trato gastrintestinal. o modelo biomatemático utilizado mostrou-se eficiente em explicar o fluxo do fósforo no organismo de suínos em crescimento. A fitase interferiu no fluxo biológico do P do compartimento C1 para o C3 e no refluxo dos compartimentos C3 e C4 para o C1. O nível 759 UF/kg de ração disponibilizou mais eficientemente o fósforo orgânico para o metabolismo dos suínos.The study was conducted to evaluate the biological flow of P in pigs fed diets based on corn, soybean meal, defatted rice bran (DRB and soybean oil, with increasing phytase levels (253, 759, 1265 and 1748 PU/kg of diet, using mathematics models. The model was deterministic and compartimental, in which the gastrintestinal tract (GIT (C1, the plasma C2, the bones (C3 and the soft tissues (liver, heart, kidney and muscle (C4 represented the compartments. Metabolism data and kinetics of P in tissues were used in the model, obtained by the isotopic dilution technique. The

  7. Synchronous Ectopic Pancreases in the Cardia and Antrum of the Stomach: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Yie, Mi yeon; Kim, Min Jeong; Lee, In Jae; Yang, Dae Hyun; Jun, Sun Young; Min, Kwang seon [Hallym University Medical Center, Anyang (Korea, Republic of); Jang, Kyung Mi [Sungkyunkwan University School of Medicine, Seoul (Korea, Republic of)

    2010-04-15

    Ectopic pancreas is most commonly found in the antrum of the stomach, duodenum, or proximal jejunum. Rarely ectopic pancreas in the proximal stomach has been reported. Moreover, the coexistence of two ectopic pancreases at gastric cardia and antrum in a patient has not been reported. Ectopic pancreas usually appears as a submucosal mass, and it is difficult to differentiate between ectopic pancreas and other common submucosal tumors, such as a gastrointestinal stromal tumor (GIST) or leiomyoma. Here, we present a case of the coexistence of two ectopic pancreases at cardia and antrum of the stomach in a 60-year-old man, which was preoperatively misdiagnosed as GIST

  8. Gastrointestinal stromal tumours: Correlation of modified NIH risk stratification with diffusion-weighted MR imaging as an imaging biomarker

    International Nuclear Information System (INIS)

    Kang, Tae Wook; Kim, Seong Hyun; Jang, Kyung Mi; Choi, Dongil; Ha, Sang Yun; Kim, Kyoung-Mee; Kang, Won Ki; Kim, Min Ji

    2015-01-01

    Highlights: • Except size and necrosis, conventional MR findings of GISTs were not significantly different according to the modified NIH criteria. • The ADC values of GISTs were negatively correlated with the modified NIH criteria. • The ADC value can be helpful for the determination of intermediate or high-risk GISTs. - Abstract: Purpose: To evaluate the correlation of risk grade of gastrointestinal stromal tumours (GISTs) based on modified National Institutes of Health (NIH) criteria with conventional magnetic resonance (MR) imaging and diffusion-weighted (DW) imaging. Methods: We included 22 patients with histopathologically proven GISTs in the stomach or small bowel who underwent pre-operative gadoxetic acid-enhanced MR imaging and DW imaging. We retrospectively assessed correlations between morphologic findings, qualitative (signal intensity, consensus from two observers) and quantitative (degree of dynamic enhancement using signal intensity of tumour/muscle ratio and apparent diffusion coefficient [ADC]) values, and the modified NIH criteria for risk stratification. Spearman partial correlation analysis was used to control for tumour size as a confounding factor. The optimal cut-off level of ADC values for intermediate or high risk GISTs was analyzed using a receiver operating characteristic analysis. Results: Except tumour size and necrosis, conventional MR imaging findings, including the degree of dynamic enhancement, were not significantly different according to the modified NIH criteria (p > 0.05). Tumour ADC values were negatively correlated with the modified NIH criteria, before and after adjustment of tumour size (ρ = −0.754; p < 0.001 and ρ = −0.513; p = 0.017, respectively). The optimal cut-off value for the determination of intermediate or high-risk GISTs was 1.279 × 10 −3 mm 2 /s (100% sensitivity, 69.2% specificity, 81.8% accuracy). Conclusion: Except tumour size and necrosis, conventional MR imaging findings did not correlate with

  9. Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

    Directory of Open Access Journals (Sweden)

    Philippe Rochigneux

    2017-01-01

    Full Text Available Gastrointestinal stromal tumours (GISTs are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.

  10. Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review.

    Science.gov (United States)

    Rochigneux, Philippe; Mescam-Mancini, Lénaig; Perrot, Delphine; Bories, Erwan; Moureau-Zabotto, Laurence; Sarran, Anthony; Guiramand, Jérôme; Bertucci, François

    2017-01-01

    Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.

  11. Synchronous Ectopic Pancreases in the Cardia and Antrum of the Stomach: A Case Report

    International Nuclear Information System (INIS)

    Yie, Mi yeon; Kim, Min Jeong; Lee, In Jae; Yang, Dae Hyun; Jun, Sun Young; Min, Kwang seon; Jang, Kyung Mi

    2010-01-01

    Ectopic pancreas is most commonly found in the antrum of the stomach, duodenum, or proximal jejunum. Rarely ectopic pancreas in the proximal stomach has been reported. Moreover, the coexistence of two ectopic pancreases at gastric cardia and antrum in a patient has not been reported. Ectopic pancreas usually appears as a submucosal mass, and it is difficult to differentiate between ectopic pancreas and other common submucosal tumors, such as a gastrointestinal stromal tumor (GIST) or leiomyoma. Here, we present a case of the coexistence of two ectopic pancreases at cardia and antrum of the stomach in a 60-year-old man, which was preoperatively misdiagnosed as GIST

  12. Gastrointestinal stromal tumours: Correlation of modified NIH risk stratification with diffusion-weighted MR imaging as an imaging biomarker

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Tae Wook [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Kim, Seong Hyun, E-mail: kshyun@skku.edu [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Jang, Kyung Mi; Choi, Dongil [Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Ha, Sang Yun; Kim, Kyoung-Mee [Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Kang, Won Ki [Division of Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135-710 (Korea, Republic of); Kim, Min Ji [Biostatics Unit, Samsung Biomedical Research Institute, Samsung Medical Center, Seoul 135-710 (Korea, Republic of)

    2015-01-15

    Highlights: • Except size and necrosis, conventional MR findings of GISTs were not significantly different according to the modified NIH criteria. • The ADC values of GISTs were negatively correlated with the modified NIH criteria. • The ADC value can be helpful for the determination of intermediate or high-risk GISTs. - Abstract: Purpose: To evaluate the correlation of risk grade of gastrointestinal stromal tumours (GISTs) based on modified National Institutes of Health (NIH) criteria with conventional magnetic resonance (MR) imaging and diffusion-weighted (DW) imaging. Methods: We included 22 patients with histopathologically proven GISTs in the stomach or small bowel who underwent pre-operative gadoxetic acid-enhanced MR imaging and DW imaging. We retrospectively assessed correlations between morphologic findings, qualitative (signal intensity, consensus from two observers) and quantitative (degree of dynamic enhancement using signal intensity of tumour/muscle ratio and apparent diffusion coefficient [ADC]) values, and the modified NIH criteria for risk stratification. Spearman partial correlation analysis was used to control for tumour size as a confounding factor. The optimal cut-off level of ADC values for intermediate or high risk GISTs was analyzed using a receiver operating characteristic analysis. Results: Except tumour size and necrosis, conventional MR imaging findings, including the degree of dynamic enhancement, were not significantly different according to the modified NIH criteria (p > 0.05). Tumour ADC values were negatively correlated with the modified NIH criteria, before and after adjustment of tumour size (ρ = −0.754; p < 0.001 and ρ = −0.513; p = 0.017, respectively). The optimal cut-off value for the determination of intermediate or high-risk GISTs was 1.279 × 10{sup −3} mm{sup 2}/s (100% sensitivity, 69.2% specificity, 81.8% accuracy). Conclusion: Except tumour size and necrosis, conventional MR imaging findings did not

  13. Survival of gastrointestinal stromal tumor patients in the imatinib era: life raft group observational registry

    International Nuclear Information System (INIS)

    Call, Jerry; Walentas, Christopher D; Eickhoff, Jens C; Scherzer, Norman

    2012-01-01

    Gastrointestinal stromal tumors (GIST), one of the most common mesenchymal tumors of the gastrointestinal tract, prior to routine immunohistochemical staining and the introduction of tyrosine kinase inhibitors, were often mistaken for neoplasms of smooth muscle origin such as leiomyomas, leiomyosarcomas or leiomyoblastomas. Since the advent of imatinib, GIST has been further delineated into adult- (KIT or PDGFRα mutations) and pediatric- (typified by wild-type GIST/succinate dehydrogenase deficiencies) types. Using varying gender ratios at age of diagnosis we sought to elucidate prognostic factors for each sub-type and their impact on overall survival. This is a long-term retrospective analysis of a large observational study of an international open cohort of patients from a GIST research and patient advocacy's lifetime registry. Demographic and disease-specific data were voluntarily supplied by its members from May 2000-October 2010; the primary outcome was overall survival. Associations between survival and prognostic factors were evaluated by univariate Cox proportional hazard analyses, with backward selection at P < 0.05 used to identify independent factors. Inflections in gender ratios by age at diagnosis in years delineated two distinct groups: above and below age 35 at diagnosis. Closer analysis confirmed the above 35 age group as previously reported for adult-type GIST, typified by mixed primary tumor sites and gender, KIT or PDGFRα mutations, and shorter survival times. The pediatric group (< age 18 at diagnosis) was also as previously reported with predominantly stomach tumors, females, wild-type GIST or SDH mutations, and extended survival. 'Young adults' however formed a third group aged 18-35 at diagnosis, and were a clear mix of these two previously reported distinct sub-types. Pediatric- and adult-type GIST have been previously characterized in clinical settings and these observations confirm significant prognostic factors for each

  14. Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: Case report

    Directory of Open Access Journals (Sweden)

    Waring Paul

    2004-10-01

    Full Text Available Abstract Background The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are sanctuary sites such as the central nervous system where imatinib does not achieve adequate concentrations. We describe the case of a man with metastatic GIST who experienced multiple cerebral relapses of disease while systemic disease progression appeared to be controlled by imatinib. Case presentation A 47-year-old man presented in July 1999 with a jejunal GIST with multiple hepatic metastases. The jejunal primary was resected and after unsuccessful cytoreductive chemotherapy, the liver metastases were also resected in December 1999. The patient subsequently relapsed in August 2001 with symptomatic hepatic, subcutaneous gluteal, left choroidal and right ocular metastases all confirmed on CT and PET scanning. Biopsy confirmed recurrent GIST. MRI and lumbar puncture excluded central nervous system involvement. The patient was commenced on imatinib 400 mg bd in September 2001 through a clinical trial. The symptoms improved with objective PET and CT scan response until December 2002 when the patient developed a right-sided foot drop. MRI scan showed a left parasagittal tumor which was resected and confirmed histologically to be metastatic GIST. Imatinib was ceased pre-operatively due to the trial protocol but recommenced in February 2003 on a compassionate use program. The left parasagittal metastasis recurred and required subsequent re-excision in September 2003 and January 2004. Control of the systemic GIST was temporarily lost on reduction of the dose of imatinib (due to limited drug supply but on increasing the dose back to 800 mg per day, systemic disease was stabilized for a period of time before generalised progression

  15. Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: Case report

    International Nuclear Information System (INIS)

    Hughes, Brett; Yip, Desmond; Goldstein, David; Waring, Paul; Beshay, Victoria; Chong, Guan

    2004-01-01

    The management of unresectable or metastatic gastrointestinal stromal tumors (GISTs) has previously been difficult as they are resistant to conventional chemotherapy and radiation. The development of imatinib mesylate has made a major impact on the management of advanced GISTs. It is apparent that there are sanctuary sites such as the central nervous system where imatinib does not achieve adequate concentrations. We describe the case of a man with metastatic GIST who experienced multiple cerebral relapses of disease while systemic disease progression appeared to be controlled by imatinib. A 47-year-old man presented in July 1999 with a jejunal GIST with multiple hepatic metastases. The jejunal primary was resected and after unsuccessful cytoreductive chemotherapy, the liver metastases were also resected in December 1999. The patient subsequently relapsed in August 2001 with symptomatic hepatic, subcutaneous gluteal, left choroidal and right ocular metastases all confirmed on CT and PET scanning. Biopsy confirmed recurrent GIST. MRI and lumbar puncture excluded central nervous system involvement. The patient was commenced on imatinib 400 mg bd in September 2001 through a clinical trial. The symptoms improved with objective PET and CT scan response until December 2002 when the patient developed a right-sided foot drop. MRI scan showed a left parasagittal tumor which was resected and confirmed histologically to be metastatic GIST. Imatinib was ceased pre-operatively due to the trial protocol but recommenced in February 2003 on a compassionate use program. The left parasagittal metastasis recurred and required subsequent re-excision in September 2003 and January 2004. Control of the systemic GIST was temporarily lost on reduction of the dose of imatinib (due to limited drug supply) but on increasing the dose back to 800 mg per day, systemic disease was stabilized for a period of time before generalised progression occurred. This case illustrates that the brain can be a

  16. Reversible cerebral vasconstriction syndrome: A case report

    International Nuclear Information System (INIS)

    Lee, Jeong Sub; Park, Ji Kang; Kim, Seung Hyoung; Jeong, Sun Young

    2013-01-01

    We report a 46-year-old woman patient with reversible cerebral vasoconstriction syndrome (RCVS). She presented with severe headache, multiple cerebral infarction, and multifocal severe stenosis in the intracranial arteries on magnetic resonance angiography (MRA). One month after the episode, a small bowel gastrointestinal stromal tumor (GIST) was incidentally detected during the evaluation of severe anemia and GIST was removed. Follow-up MRA was performed 3 months and 1 year after an initial attack of headache, and multifocal severe intracranial arterial stenotic lesions were completely resolved, she did not experience any episode of RCVS during the 2 years.

  17. Reversible cerebral vasconstriction syndrome: A case report

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Jeong Sub; Park, Ji Kang; Kim, Seung Hyoung; Jeong, Sun Young [Jeju National University Hospital, Jeju National University School of Medicine, Jeju (Korea, Republic of)

    2013-11-15

    We report a 46-year-old woman patient with reversible cerebral vasoconstriction syndrome (RCVS). She presented with severe headache, multiple cerebral infarction, and multifocal severe stenosis in the intracranial arteries on magnetic resonance angiography (MRA). One month after the episode, a small bowel gastrointestinal stromal tumor (GIST) was incidentally detected during the evaluation of severe anemia and GIST was removed. Follow-up MRA was performed 3 months and 1 year after an initial attack of headache, and multifocal severe intracranial arterial stenotic lesions were completely resolved, she did not experience any episode of RCVS during the 2 years.

  18. Fuzzy-trace theory: dual processes in memory, reasoning, and cognitive neuroscience.

    Science.gov (United States)

    Brainerd, C J; Reyna, V F

    2001-01-01

    Fuzzy-trace theory has evolved in response to counterintuitive data on how memory development influences the development of reasoning. The two traditional perspectives on memory-reasoning relations--the necessity and constructivist hypotheses--stipulate that the accuracy of children's memory for problem information and the accuracy of their reasoning are closely intertwined, albeit for different reasons. However, contrary to necessity, correlational and experimental dissociations have been found between children's memory for problem information that is determinative in solving certain problems and their solutions of those problems. In these same tasks, age changes in memory for problem information appear to be dissociated from age changes in reasoning. Contrary to constructivism, correlational and experimental dissociations also have been found between children's performance on memory tests for actual experience and memory tests for the meaning of experience. As in memory-reasoning studies, age changes in one type of memory performance do not seem to be closely connected to age changes in the other type of performance. Subsequent experiments have led to dual-process accounts in both the memory and reasoning spheres. The account of memory development features four other principles: parallel verbatim-gist storage, dissociated verbatim-gist retrieval, memorial bases of conscious recollection, and identity/similarity processes. The account of the development of reasoning features three principles: gist extraction, fuzzy-to-verbatim continua, and fuzzy-processing preferences. The fuzzy-processing preference is a particularly important notion because it implies that gist-based intuitive reasoning often suffices to deliver "logical" solutions and that such reasoning confers multiple cognitive advantages that enhance accuracy. The explanation of memory-reasoning dissociations in cognitive development then falls out of fuzzy-trace theory's dual-process models of memory and

  19. Cani kunagine laulja Tallinnas. Led Zeppelin koguneb taas? Ian Brown müüb oma maja liiga kallilt

    Index Scriptorium Estoniae

    2002-01-01

    Damo Suzuki ja tema uue ansambli Damo Suzuki Network esinemisest Von Krahli Teatri baaris 21.oktoobril. Led Zeppelini plaanist korraldada järgmisel aastal kontserttuur mööda USAd. Ansambli Stone Roses kunagise solisti Ian Browni suvemaja müügist Põhja-Walesis Llithfaenis

  20. Imatinib mesylate induces responses in patients with liver metastases from gastrointestinal stromal tumor failing intra-arterial hepatic chemotherapy

    Directory of Open Access Journals (Sweden)

    Fiorentini Giammaria

    2006-01-01

    Full Text Available Background: Imatinib mesylate represents a real major paradigm shift in cancer therapy, targeting the specific molecular abnormalities, crucial in the etiology of tumor. Intra-arterial hepatic chemotherapy (IAHC followed by embolization, has been considered an interesting palliative option for patients with liver metastases from gastrointestinal stromal tumor (GIST, due to the typically hypervascular pattern of the tumor. Aims: We report our experience with IAHC followed by Imatinib mesylate, in order to show the superiority of the specific molecular approach in liver metastases from GIST. Materials and Methods: Three patients (pts with pretreated massive liver metastases from GIST, received IAHC with Epirubicin 50 mg/mq, every 3 weeks for 6 cycles. At the evidence of progression, they received Imatinib mesylate. Results: We observed progressive diseases in all cases. In 1998, one patient underwent Thalidomide at 150 mg orally, every day for 4 months, with evidence of stable disease and clinical improvement. In 2001, two patients received Imatinib mesylate at 400 mg orally, every day, with evidence of partial response lasting 18+ months and 16 months. One of them had grade 3 neutropenia, with suspension of therapy for 3 weeks. Conclusion: No patient treated with IAHC, reported objective responses, but two of them obtained partial response after the assumption of Imatinib mesylate and one showed temporary stabilization with thalidomide. Imatinib mesylate represents a new opportunity in GIST therapy, targeting the specific molecular alteration. It seems to be superior to conventional intra arterial hepatic chemotherapy.

  1. Constructivism and Reflectivism as the Logical Counterparts in TESOL: Learning Theory versus Teaching Methodology

    Science.gov (United States)

    al Mahmud, Abdullah

    2013-01-01

    The gist of the entire constructivist learning theory is that learners are self-builders of their learning that occurs through a mental process in a social context or communication setting, and teachers as facilitators generate learning by creating the expected environment and/or utilizing the process. This article theoretically proves…

  2. Aasta 2003 haagiseturul / Ahto Perling

    Index Scriptorium Estoniae

    Perling, Ahto, 1970-

    2004-01-01

    Ülevaade haagiste tootmisest ja müügist Lääne- ja Ida-Euroopas 2003. aasta andmetel. Diagrammid: Uute haagiste müük 2003; Madelpoolhaagiste müük 2003; Külmikpoolhaagiste müük 2003; Konteinerpoolhaagiste müük 2003

  3. Mazeikiu refinery goes on the defensive

    Index Scriptorium Estoniae

    2005-01-01

    20% Mazeikiu Nafta kasumist moodustab kütusemüügist teenitav tulu ja 80% teenib ettevõte äritegevusest Ameerika Ühendriikide, Lääne-Euroopa, Poola, Eesti ja Lätiga. Leedu peaminister Algirdas Brazauskas kritiseeris ettevõtet kõrgete hindade tõttu

  4. “What’s Cooking?”

    DEFF Research Database (Denmark)

    Svejenova, Silviya

    2016-01-01

    “What’s cooking?” is old-fashioned slang for asking about what is happening or what someone is planning. In this chapter, it denotes an approach to prospective data collection in qualitative research and captures the gist of a case study from the field of haute cuisine that inspired the saying...

  5. Pärjatud disaintool Haiku

    Index Scriptorium Estoniae

    2005-01-01

    Isku OY disaineri Tapio Anttila loodud tool Haiku pälvis rahvusvahelisel disainikonkursil ADEX 2004 (Award for Design Excellence) mööblikategoorias Adex Silver preemia. Eestis jõuab tool müüki maikuus, tooli valmistatakse kasest ja pöögist

  6. Dollar võib põhjustada ootamatuid arenguid / Sirje Rank

    Index Scriptorium Estoniae

    Rank, Sirje, 1966-

    2004-01-01

    USA dollari jätkuv odavnemine ja jooksevkonto puudujäägist ning eelarvedefitsiidist tingitud ebastabiilne majanduskasv võivad analüütikute hinnangul avaldada negatiivset mõju kogu maailma majandusele. Diagramm: Dollar aastaga kukkunud ligi viiendiku

  7. Internal Medicine residents use heuristics to estimate disease probability

    Directory of Open Access Journals (Sweden)

    Sen Phang

    2015-12-01

    Conclusions: Our findings suggest that despite previous exposure to the use of Bayesian reasoning, residents use heuristics, such as the representative heuristic and anchoring with adjustment, to estimate probabilities. Potential reasons for attribute substitution include the relative cognitive ease of heuristics vs. Bayesian reasoning or perhaps residents in their clinical practice use gist traces rather than precise probability estimates when diagnosing.

  8. CO₂ heitkoguste müügil on mitmedki konksud küljes / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2009-01-01

    Ülejäävaid CO₂ heitkoguste ühikuid ostvad riigid tahavad, et müügist saadud raha kulutataks nn. rohelistele projektidele, probleem võib tekkida ka heitkoguste ühikute ülejäägile turu leidmisega

  9. How Fuzzy-Trace Theory Predicts True and False Memories for Words, Sentences, and Narratives

    Science.gov (United States)

    Reyna, Valerie F.; Corbin, Jonathan C.; Weldon, Rebecca B.; Brainerd, Charles J.

    2016-01-01

    Fuzzy-trace theory posits independent verbatim and gist memory processes, a distinction that has implications for such applied topics as eyewitness testimony. This distinction between precise, literal verbatim memory and meaning-based, intuitive gist accounts for memory paradoxes including dissociations between true and false memory, false memories outlasting true memories, and developmental increases in false memory. We provide an overview of fuzzy-trace theory, and, using mathematical modeling, also present results demonstrating verbatim and gist memory in true and false recognition of narrative sentences and inferences. Results supported fuzzy-trace theory's dual-process view of memory: verbatim memory was relied on to reject meaning-consistent, but unpresented, sentences (via recollection rejection). However, verbatim memory was often not retrieved, and gist memory supported acceptance of these sentences (via similarity judgment and phantom recollection). Thus, mathematical models of words can be extended to explain memory for complex stimuli, such as narratives, the kind of memory interrogated in law. PMID:27042402

  10. False Memory for Orthographically versus Semantically Similar Words in Adolescents with Dyslexia: A Fuzzy-Trace Theory Perspective

    Science.gov (United States)

    Obidzinski, Michal; Nieznanski, Marek

    2017-01-01

    The presented research was conducted in order to investigate the connections between developmental dyslexia and the functioning of verbatim and gist memory traces--assumed in the fuzzy-trace theory. The participants were 71 high school students (33 with dyslexia and 38 without learning difficulties). The modified procedure and multinomial model of…

  11. Processes Underlying Developmental Reversals in False-Memory Formation: Comment on Brainerd, Reyna, and Ceci (2008)

    Science.gov (United States)

    Ghetti, Simona

    2008-01-01

    C. J. Brainerd, V. F. Reyna, and S. J. Ceci (2008) reviewed compelling evidence of developmental reversals in false-memory formation (i.e., younger children exhibit lower false-memory rates than do older children and adults) and proposed that this phenomenon depends on the development of gist processing (i.e., the ability to identify and process…

  12. Circulating levels of cell adhesion molecule L1 as a prognostic marker in gastrointestinal stromal tumor patients

    International Nuclear Information System (INIS)

    Zander, Hilke; Kaifi, Jussuf; Rawnaq, Tamina; Wedemeyer, Max von; Tachezy, Michael; Kunkel, Miriam; Wolters, Gerrit; Bockhorn, Maximilian; Schachner, Melitta; Izbicki, Jakob R

    2011-01-01

    L1 cell adhesion molecule (CD171) is expressed in many malignant tumors and its expression correlates with unfavourable outcome. It thus represents a target for tumor diagnosis and therapy. An earlier study conducted by our group identified L1 expression levels in primary gastrointestinal stromal tumors (GIST) as a prognostic marker. The aim of the current study was to compare L1 serum levels of GIST patients with those of healthy controls and to determine whether levels of soluble L1 in sera could serve as a prognostic marker. Using a sensitive enzyme-linked immunosorbent assay (ELISA), soluble L1 was measured in sera of 93 GIST patients und 151 healthy controls. Soluble L1 levels were then correlated with clinicopathological data. Median levels of soluble L1 were significantly higher (p < 0.001; Mann-Whitney U test) in sera of GIST patients compared to healthy individuals. Median soluble L1 levels were particularly elevated in patients with recurrence and relapse (p < 0.05; Mann Whitney U test). These results suggest that high soluble L1 levels predict poor prognosis and may thus be a promising tumor marker that can contribute to individualise therapy

  13. Angiogenesis Research to Improve Therapies for Vascular Leak Syndromes, Intra-abdominal Adhesions, and Arterial Injuries

    Science.gov (United States)

    2008-04-01

    for example, infantile haemangiomas6, peptic ulcers7, ocular neovascularization8, rheumatoid arthritis9 and atherosclerosis3,10,11. This led to a...Symptoms Diabetic retinopathy Loss of vision Rheumatoid arthritis2 Pain and immobility from destroyed cartilage Atherosclerotic plaques3 Chest pain, dyspnoea...2006) NSCLC, GIST, diabetic retinopathy, vascular occlusions, retinopathy of prematurity, colorectal, breast, ovarian, peritoneal, pancreatic

  14. JPRS Report, Science & Technology, USSR: Life Sciences

    Science.gov (United States)

    1989-02-10

    with sugar diabetes , ophthalmolo- gists see those with glaucoma, and rheumatologists see those rheumatic heart disease. In cardiovascular dis- eases...in the structure of infantile mortality. Chronic patients suffering from hereditary diseases occupy 20 percent of the beds in children’s infirmaries

  15. Attention: A Machine Learning Perspective

    DEFF Research Database (Denmark)

    Hansen, Lars Kai

    2012-01-01

    We review a statistical machine learning model of top-down task driven attention based on the notion of ‘gist’. In this framework we consider the task to be represented as a classification problem with two sets of features — a gist of coarse grained global features and a larger set of low...

  16. Picasso, Chagall ja Mir̤ tulevad müüki

    Index Scriptorium Estoniae

    2001-01-01

    Vaal-galerii avatud 15 tippkunstniku 27 töö näitusmüügist "Suured ja unustamatud", kus eksponeeriti Georges Braque'i, Paul Delvaux, Pablo Picasso, Joan Mir̤, Karel Appeli, Jim Dine, Nike de Saint-Phalle, Marc Chagalli, Antoni Tapiesi, Antonio Saura jt. töid

  17. Endo-laparoscopic rendezvous approach for pericardia with gastric posterior wall of gastrointestinal stromal tumor: Analysis of 52 consecutive cases

    Directory of Open Access Journals (Sweden)

    Po Ding

    2014-01-01

    Conclusions: Endo-laparoscopic rendezvous approach is considered to represent the next revolution in surgery. The new technique is reliable and effective in clinical application, due to the advantages of accurate and quick localization for pericardial GIST within gastric posterior wall.

  18. Fulltext PDF

    Indian Academy of Sciences (India)

    2017-02-10

    Feb 10, 2017 ... gists when speaking of the balance between stability and activity, was not limited to the work of protein engineers, ... What is searched for in a large family of homologous pro- .... Morange M 2012 A new life for allostery.

  19. Targeting gastrointestinal stromal tumors: the role of regorafenib

    Directory of Open Access Journals (Sweden)

    Schroeder B

    2016-05-01

    Full Text Available Brett Schroeder,1 Zula Li,2,3 Lee D Cranmer,2,3 Robin L Jones,4 Seth M Pollack2,3 1College of Human Medicine, Michigan State University, Grand Rapids, MI, 2Division of Medical Oncology, University of Washington, 3Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA, USA; 4Royal Marsden Hospital, Institute of Cancer Research, London, UK Abstract: Gastrointestinal stromal tumor (GIST is a devastating disease in the metastatic setting, but its natural history has been dramatically altered by the development of small molecule tyrosine kinase inhibitors, most notably imatinib. Although patients with advanced GIST live much longer today than they did in the past, imatinib-refractory disease remains a tremendous problem. For disease that is refractory to imatinib and sunitinib, regorafenib is an excellent option. In this review, we discuss the biology and clinical work establishing regorafenib as the standard of care for advanced GIST refractory to both imatinib and sunitinib. Keywords: regorafenib, GIST, refractory, imatinib

  20. "Kalev" izbavilsja ot pishtshevõhh "dobavok" / Hilda Vall

    Index Scriptorium Estoniae

    Vall, Hilda

    2007-01-01

    Ärimees Oliver Kruuda teatas oma piimatööstuse Tere ja kondiitritööstuse Kalev müügist Eesti investeerimisfirmale Alta Capital Partners, põhjendades oma otsust sooviga edaspidi tegutseda kinnisvara ja meedia vallas

  1. Browse Title Index

    African Journals Online (AJOL)

    Items 1 - 50 of 93 ... Issue, Title. Vol 5 (2013), A cost-effective Geographic Information Systems for Transportation (GIS-T) application for traffic congestion analyses in the Developing World, Abstract PDF. E Agyemang. Vol 3 (2011), A Historical and Gendered Perspective on HIV / AIDS in Botswana, Abstract PDF. J Hesselberg ...

  2. A cost-effective Geographic Information Systems for Transportation ...

    African Journals Online (AJOL)

    A cost-effective Geographic Information Systems for Transportation (GIS-T) application for traffic congestion analyses in the Developing World. ... The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader). If you would like ...

  3. Austraalia peaminister jagas eelarve ülejäägid rahvale / Airi Ilisson-Cruz

    Index Scriptorium Estoniae

    Ilisson-Cruz, Airi, 1980-

    2009-01-01

    Austraalia peaminister Kevin Rudd'i majanduskriisiga võitlemise plaanist, mis nägi ette 2008. aasta detsembris ühiskonna vaesemate kihtide, pensionäride, noorte ja lastega perede rahalist toetamist riigi eelarveülejäägist, ka 2009. aastal jätkub toetuste jagamine. Graafik: Töötus Austraalias viimastel aastatel

  4. JPRS Report, Near East & South Asia

    Science.gov (United States)

    1990-09-28

    34 a socio-economic essay whose gist is that the world financial casino finances the world money printer, the economy of the United States. Just...JPRS-NEA-90-054 28 September 1990 "Neither the melody nor the lyrics express the Zionist revolution, but ’Hatiqvah’ was sanctified in ceremonies in

  5. Shaanxi Youser Group Signs Strategic Cooperation Agreement with China XD Group

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>On November 6, the signing ceremony for the strategic cooperation agreement between four provincial enterprises including Shaanxi Youser Group and China XD Group was heldin Xi’an. This was a strategic move taken by the group to carry out the gist of the provincial CPC committee

  6. Оценка и выбор канала сбыта металлургического производства

    OpenAIRE

    Рыльцев, М. С.

    2015-01-01

    This paper considers the problem of determining the distribution channels of metallurgicalproducts. The basis for the study was taken method of expert evaluations; the gist of it is that the expert willbe made comprehensive assessment of distribution channels for according to certain criteria. Based on estimatesof site contents, the system selects the most effective distribution channels.

  7. Sleep to be social: The critical role of sleep and memory for social interaction.

    Science.gov (United States)

    Diekelmann, Susanne; Paulus, Frieder M; Krach, Sören

    2018-01-01

    Humans are highly social animals who critically need to remember information from social episodes in order to successfully navigate future social interactions. We propose that such episodic memories about social encounters are processed during sleep, following the learning experience, with sleep abstracting and consolidating social gist knowledge (e.g., beliefs, first impressions, or stereotypes) about others that supports relationships and interpersonal communication.

  8. On see realistlik - 400 ehitust kahe suvega ellu viia? / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2011-01-01

    CO₂ kvoodi müügist rahastatakse üle 400 objekti energiasäästlikumaks renoveerimist. Ehitusettevõtjate liidu tegevdirektori Indrek Petersoni hinnangul töö firmade taha ei jää, pigem nähakse probleemi hankeprotsesside korraldamises ning projekteerimishangete läbiviimises

  9. Ecuadorile maksti, et ta jätaks rahule Amazonase nafta / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2010-01-01

    Yasuni rahvuspargis asuv naftaleiukoht jäetakse vähemalt kümneks aastaks rahule, sest ÜRO loodud fondi kaudu makstakse Ecuadori riigikassasse 3,6 miljardit dollarit ehk ligemale pool summast, mille ta võiks nafta müügist teenida

  10. Predictive features of CT for risk stratifications in patients with primary gastrointestinal stromal tumour

    International Nuclear Information System (INIS)

    Zhou, Cuiping; Zhang, Xiang; Duan, Xiaohui; Hu, Huijun; Wang, Dongye; Shen, Jun

    2016-01-01

    To determine the predictive CT imaging features for risk stratifications in patients with primary gastrointestinal stromal tumours (GISTs). One hundred and twenty-nine patients with histologically confirmed primary GISTs (diameter >2 cm) were enrolled. CT imaging features were reviewed. Tumour risk stratifications were determined according to the 2008 NIH criteria where GISTs were classified into four categories according to the tumour size, location, mitosis count, and tumour rupture. The association between risk stratifications and CT features was analyzed using univariate analysis, followed by multinomial logistic regression and receiver operating characteristic (ROC) curve analysis. CT imaging features including tumour margin, size, shape, tumour growth pattern, direct organ invasion, necrosis, enlarged vessels feeding or draining the mass (EVFDM), lymphadenopathy, and contrast enhancement pattern were associated with the risk stratifications, as determined by univariate analysis (P < 0.05). Only lesion size, growth pattern and EVFDM remained independent risk factors in multinomial logistic regression analysis (OR = 3.480-100.384). ROC curve analysis showed that the area under curve of the obtained multinomial logistic regression model was 0.806 (95 % CI: 0.727-0.885). CT features including lesion size, tumour growth pattern, and EVFDM were predictors of the risk stratifications for GIST. (orig.)

  11. Iluravi või totaalne muutumine / Madle Mühlbach

    Index Scriptorium Estoniae

    Mühlbach, Madle

    2008-01-01

    Maal asuva eramu uuest sisekujundusest. Sisearhitekt Aivar Mühlbach. Elutoa põrand on tammelaudadest, trepitagune sein ja tualettruumi seinad on kaetud kuldkollase looduskiviga. Köögist eraldatud elutoas on firma Mang kaarekujuline diivan, Poul Henningseni disainitud valgusti Artichoke jm. 13 värv. vaadet

  12. Considering the role of radiation therapy for gastrointestinal stromal tumor

    Directory of Open Access Journals (Sweden)

    Corbin KS

    2014-05-01

    Full Text Available Kimberly S Corbin,1 Hedy L Kindler,2 Stanley L Liauw31Department of Radiation Oncology, Memorial Medical Center, Springfield, IL, USA; 2Section of Hematology/Oncology, Department of Medicine, University of Chicago, Chicago, IL, USA; 3Department of Radiation and Cellular Oncology, University of Chicago, Chicago, IL, USAAbstract: Gastrointestinal stromal tumors (GISTs are rare mesenchymal tumors arising in the gastrointestinal tract. Over the last decade, the management and prognosis of GISTs has changed dramatically with molecular characterization of the c-kit mutation and the adoption of targeted systemic therapy. Currently, the standard of care for resectable tumors is surgery, followed by adjuvant imatinib for tumors at high risk for recurrence. Inoperable or metastatic tumors are treated primarily with imatinib. Despite excellent initial response rates, resistance to targeted therapy has emerged as a common clinical problem, with relatively few therapeutic solutions. While the treatment of GISTs does not commonly include radiotherapy, radiation therapy could be a valuable contributing modality. Several case reports indicate that radiation can control locally progressive, drug-resistant disease. Further study is necessary to define whether radiation could potentially prevent or delay the onset of drug resistance, or improve outcomes when given in combination with imatinib.Keywords: GIST, imatinib, radiotherapy

  13. Uus ärimudel joogi- ja toiduautomaatide turul / Viljar Rääsk

    Index Scriptorium Estoniae

    Rääsk, Viljar

    2008-01-01

    Firma Iberia Delicatessen põhisiht on müügiautomaadid, mille eest nad renti ega hooldustasu ei küsi ning tulu ootavad omanikud ainult toidu ja joogi müügist. Vt. samas: Vendori omanikud rajasid gurmeekohvi äri; Coffee In ei loe kohviautomaate konkurendiks

  14. Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL

    NARCIS (Netherlands)

    Rikhof, B.; van der Graaf, W. T. A.; Meijer, C.; Le, P. T. K.; Meersma, G. J.; de Jong, S.; Fletcher, J. A.; Suurmeijer, A. J. H.

    2008-01-01

    Although the tyrosine kinase inhibitor imatinib has been shown to be an active agent in patients with gastrointestinal stromal tumours ( GIST), complete remissions are almost never seen and most patients finally experience disease progression during their course of treatment. An alternative

  15. Abundant Fas expression by gastrointestinal stromal tumours may serve as a therapeutic target for MegaFasL.

    NARCIS (Netherlands)

    Rikhof, B.; Graaf, W.T.A. van der; Meijer, C.; Le, P.T.; Meersma, G.J.; Jong, S. de; Fletcher, J.A.; Suurmeijer, A.J.H.

    2008-01-01

    Although the tyrosine kinase inhibitor imatinib has been shown to be an active agent in patients with gastrointestinal stromal tumours (GIST), complete remissions are almost never seen and most patients finally experience disease progression during their course of treatment. An alternative

  16. Browse Title Index

    African Journals Online (AJOL)

    Items 301 - 350 of 832 ... ... Amputation at Muhimbili Orthopaedic Institute: indications and Outcome. Abstract PDF. VM Lupondo, LM Museru, CN Mcharo ... Vol 5, No 2 (2000), Gastric outlet obstruction in Northwestern Ethiopia, Abstract PDF. Rerhanu Kotisso. Vol 17, No 2 (2012), Gastrointestinal Stromal Cell Tumor (GIST) ...

  17. Sydney ja selle maaliline naabrus / Anneli Ira

    Index Scriptorium Estoniae

    Ira, Anneli

    2013-01-01

    Sydney ümbrusesse jäävatest looduslikest vaatamisväärsustest: Royal National Park, Grand Pacific Drive, Sinimäed, Jenola koopad; austraalia köögist, majutuse ning transpordi alaseid nõuandeid jne

  18. Keila-Joa loss presidendi uueks residentsiks?

    Index Scriptorium Estoniae

    2007-01-01

    Riigi Kinnisvara AS võttis presidendi kantselei palvel müügist maha Keila-Joa lossikompleksi. Lossist võib tulevikus kujuneda riigipea residents. Ilmunud ka: Eesti Elu 15. juuni 2007, lk. 17, pealk.: Keila-Joale presidendi uus residents?; Eesti Hääl 10. aug. 2007, lk. 1, pealk.: Keila-Joale tuleb presidendi uus residents

  19. Concurrent Male Gynecomastia and Testicular Hydrocele after Imatinib Mesylate Treatment of a Gastrointestinal Stromal Tumor

    Science.gov (United States)

    Kim, Hawk; Chang, Heung-Moon; Ryu, Min-Hee; Kim, Tae-Won; Sohn, Hee-Jung; Kim, So-Eun; Kang, Hye-Jin; Park, Sarah; Lee, Jung-Shin

    2005-01-01

    We report a gastrointestinal stromal tumor (GIST) patient with male gynecomastia and testicular hydrocele after treatment with imatinib mesylate. A 42 yr-old male patient presented for management of hepatic masses. Two years earlier, he had undergone a small bowel resection to remove an intraabdominal mass later shown to be a GIST, followed by adjuvant radiation therapy. At presentation, CT scan revealed multiple hepatic masses, which were compatible with metastatic GIST, and he was prescribed imatinib 400 mg/day. During treatment, he experienced painful enlargement of the left breast and scrotal swelling. Three months after cessation of imatinib treatment, the tumors recurred, and, upon recommencing imatinib, he experienced painful enlargement of the right breast and scrotal swelling. He was diagnosed with male gynecomastia caused by decreased testosterone and non-communicative testicular hydrocele. He was given androgen support and a hydrocelectomy, which improved his gynecomastia. The mechanism by which imatinib induces gynecomastia and hydrocele is thought to be associated with an inhibition of c-KIT and platelet-derive growth factor. This is the first report, to our knowledge, describing concurrent male gynecomastia and testicular hydrocele after imatinib treatment of a patient with GIST. PMID:15953881

  20. Case report

    African Journals Online (AJOL)

    ebutamanya

    2013-07-03

    Jul 3, 2013 ... Key words: Appendiceal GIST, peritonitis, surgery, CD34. Received: ... The Pan African Medical Journal - ISSN 1937-8688. This is an Open ... A 75-year-old man was brought to the emergency department with a 48-hour ...

  1. Köök - meelte ateljee / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2008-01-01

    2008. a. valminud õppeköögist "Köök" Tallinnas Pikk t. 42. Sisekujundus: Indrek Kasela, Sikke Sumari (omanikud). Paekivi- ja punasetest tellistest seintega ruumi kaunistab moodne kunst. Skulpturaalse veini- ja raamaturiiuli on kavandanud Edith Karlson ja Flo Kasearu, lühtri autor on Anna Roomet

  2. TeliaSonera ups the ante in Lattelecom sell-off

    Index Scriptorium Estoniae

    2008-01-01

    TeliaSonera esindaja Kenneth Karlberg pakkus peaminister Godmanisele Lattelecomi ja LMT eest 70 miljonit latti rohkem kui valitsus saaks Lattelecomi müügist USA investeerimisfirmale Blackstone ja Lattelecomi töötajatele. Peaminister Godmanis nimetab Lattelecomi erastamisläbirääkimisi raskeks

  3. Circadian Rhythms

    Indian Academy of Sciences (India)

    IAS Admin

    thus appear to be simple responses of living beings to cyclic presence/absence of ... For example, during leaf movement rhythms, leaves alternate between open and closed states .... gist of his time, in an elegant experiment (Box 2) to study the navigational .... diurnal rhythms as true biological timekeepers, a question which.

  4. Kuhu investeerida ettevõtte müügiga teenitud raha? / Peeter Raidla

    Index Scriptorium Estoniae

    Raidla, Peeter, 1955-

    2008-01-01

    Investor Rain Lõhmus ning ärimehed Elmut Paavel ja Raivo Hein räägivad oma põhimõtetest ja kogemustest ettevõtete müügist laekunud raha paigutamisel. Lisa: Valik viimaste aastate suurtehinguid. Vt. samas: Intervjuu Ambient Sound Investments tegevjuhi Tauno Tatsiga. Skype'i mehed jätkavad innovatiivselt

  5. Exploring the influence of encoding format on subsequent memory.

    Science.gov (United States)

    Turney, Indira C; Dennis, Nancy A; Maillet, David; Rajah, M Natasha

    2017-05-01

    Distinctive encoding is greatly influenced by gist-based processes and has been shown to suffer when highly similar items are presented in close succession. Thus, elucidating the mechanisms underlying how presentation format affects gist processing is essential in determining the factors that influence these encoding processes. The current study utilised multivariate partial least squares (PLS) analysis to identify encoding networks directly associated with retrieval performance in a blocked and intermixed presentation condition. Subsequent memory analysis for successfully encoded items indicated no significant differences between reaction time and retrieval performance and presentation format. Despite no significant behavioural differences, behaviour PLS revealed differences in brain-behaviour correlations and mean condition activity in brain regions associated with gist-based vs. distinctive encoding. Specifically, the intermixed format encouraged more distinctive encoding, showing increased activation of regions associated with strategy use and visual processing (e.g., frontal and visual cortices, respectively). Alternatively, the blocked format exhibited increased gist-based processes, accompanied by increased activity in the right inferior frontal gyrus. Together, results suggest that the sequence that information is presented during encoding affects the degree to which distinctive encoding is engaged. These findings extend our understanding of the Fuzzy Trace Theory and the role of presentation format on encoding processes.

  6. A Probabilistic Model of Visual Working Memory: Incorporating Higher Order Regularities into Working Memory Capacity Estimates

    Science.gov (United States)

    Brady, Timothy F.; Tenenbaum, Joshua B.

    2013-01-01

    When remembering a real-world scene, people encode both detailed information about specific objects and higher order information like the overall gist of the scene. However, formal models of change detection, like those used to estimate visual working memory capacity, assume observers encode only a simple memory representation that includes no…

  7. Hitler, Stalin ja Vana Toomas koos / Helen Eelrand

    Index Scriptorium Estoniae

    Eelrand, Helen, 1971-

    2004-01-01

    Ajalooliste esemete, eelkõige kommunistliku ja natsionaalsotsialistliku sümboolika müügist. Kommentaarid Riigikogu liikmelt Helir-Valdor Seederilt, okupatsioonimuuseumi töötajalt Rasmus Rausbergilt ja siseministeeriumi pressinõunikult Katrin Videselt. Lisa: Lenin läheb idablokis kaubaks

  8. Spatial-temporal data model and fractal analysis of transportation network in GIS environment

    Science.gov (United States)

    Feng, Yongjiu; Tong, Xiaohua; Li, Yangdong

    2008-10-01

    How to organize transportation data characterized by multi-time, multi-scale, multi-resolution and multi-source is one of the fundamental problems of GIS-T development. A spatial-temporal data model for GIS-T is proposed based on Spatial-temporal- Object Model. Transportation network data is systemically managed using dynamic segmentation technologies. And then a spatial-temporal database is built to integrally store geographical data of multi-time for transportation. Based on the spatial-temporal database, functions of spatial analysis of GIS-T are substantively extended. Fractal module is developed to improve the analyzing in intensity, density, structure and connectivity of transportation network based on the validation and evaluation of topologic relation. Integrated fractal with GIS-T strengthens the functions of spatial analysis and enriches the approaches of data mining and knowledge discovery of transportation network. Finally, the feasibility of the model and methods are tested thorough Guangdong Geographical Information Platform for Highway Project.

  9. Incidentally detected gastrointestinal stromal tumor: A case report

    Directory of Open Access Journals (Sweden)

    Tolga Canbak

    2017-12-01

    Full Text Available Gastrointestinal stromal tumors (GIST are mesenchymal tumors located primarily in the gastrointestinal tract. We aimed to present a case report of GIST incidentally detected during laparoscopic cholecystectomy.A 60-year-old woman was admitted to the emergency room due to abdominal pain for one day. The physical examination revealed sensitivity on the right upper quadrant. In the laboratory examinations, white blood cell count 6,490 k/uL, hemoglobin 12 g/dL, hematocrit 35% and other biochemical tests were normal. Abdominal ultrasound revealed hydropic gallbladder, several gallstones with a maximum diameter of 15 mm and pericholecystic fluid collection was present. Laparoscopic cholecystectomy was planned due to acute cholecystitis. In exploration, beside the presence of acute cholecystitis, a mass of approximately 5 cm, located 15 cm distal to the ligament of Treitz was detected. Laparoscopic cholecystectomy was performed. Conversion to open laparotomy was done; small intestine resection with end-to-end anastomosis was performed. Gastrointestinal stromal tumor with CD117, CD34 and S100 positivity was detected on histopathologic examination.It is thought that GISTs are mesenchymal tumors originating from precursors of Kajal cells. GISTs are usually detected in their 60s. The first option for treatment is surgical resection.

  10. Tulekul...

    Index Scriptorium Estoniae

    2008-01-01

    Märtsis toimuvatest muusikaüritustest: Tudengijazz 2008, "Matteuse Passioon" kontsertidest, muusikafestivalist Maa ja Ilm, muusikafestivalist Soul Spectrum, harfimängijast Florence Sitruk. Tanel Padari ja ansambli The Sun kontserttuurist. Jazzkaare piletitemüügist. 14. märtsil toimuvast rootsi ansambli Koop kontserdist, rootsi muusikute Mats & Morgan kontsertidest

  11. The Role of Speech-Gesture Congruency and Delay in Remembering Action Events

    Science.gov (United States)

    Galati, Alexia; Samuel, Arthur G.

    2011-01-01

    When watching others describe events, does information from their speech and gestures affect our memory representations for the gist and surface form of the described events? Does our reliance on these memory representations change over time? Forty participants watched videos of stories narrated by an actor. Each story included three target events…

  12. Designs of Concept Maps and Their Impacts on Readers' Performance in Memory and Reasoning while Reading

    Science.gov (United States)

    Tzeng, Jeng-Yi

    2010-01-01

    From the perspective of the Fuzzy Trace Theory, this study investigated the impacts of concept maps with two strategic orientations (comprehensive and thematic representations) on readers' performance of cognitive operations (such as perception, verbatim memory, gist reasoning and syntheses) while the readers were reading two history articles that…

  13. Strategic Learning in Youth with Traumatic Brain Injury: Evidence for Stall in Higher-Order Cognition

    Science.gov (United States)

    Gamino, Jacquelyn F.; Chapman, Sandra B.; Cook, Lori G.

    2009-01-01

    Little is known about strategic learning ability in preteens and adolescents with traumatic brain injury (TBI). Strategic learning is the ability to combine and synthesize details to form abstracted gist-based meanings, a higher-order cognitive skill associated with frontal lobe functions and higher classroom performance. Summarization tasks were…

  14. Non-linear M -sequences Generation Method

    Directory of Open Access Journals (Sweden)

    Z. R. Garifullina

    2011-06-01

    Full Text Available The article deals with a new method for modeling a pseudorandom number generator based on R-blocks. The gist of the method is the replacement of a multi digit XOR element by a stochastic adder in a parallel binary linear feedback shift register scheme.

  15. Eesti Enrgia müüb Eleringi hea hinnaga / Andrus Karnau

    Index Scriptorium Estoniae

    Karnau, Andrus

    2009-01-01

    Valitsus otsustas maksta põhivõrgufirma Elering eest Eesti Energia kontsernile 2,7 miljardit krooni, liskas maksab Elering Eesti Energiale ka oma kinnisvara eest. Põhivõrgu lahutamist elektritootmisest ja selle klientidele müügist nõudis Euroopa Liit. Diagrammid

  16. Application of Pun in English Advertisements

    Institute of Scientific and Technical Information of China (English)

    Tan; Li

    2015-01-01

    This paper illustrates the definition of pun,especially its features, as well as the typical application of pun in English advertisements in order to emphasize its importance in daily usage both for advertisers and to target readers.It aims to demonstrate the importance of grasping the gist of pun in English advertisements.

  17. Lotte-tooteil välismaal loodetust vähem menu / Kadri Jakobson

    Index Scriptorium Estoniae

    Jakobson, Kadri, 1970-

    2007-01-01

    Eesti joonisfilmiga "Leiutajateküla Lotte" kaasnenud Lotte-teemaliste toodete müügist on jäänud läbimurre tulemata. Lisaks sõnum "Produtsent : summad on marginaalsed" ja Klementi tegevjuhi Peeter Larini kommentaar

  18. Uued CO₂ kasukad vanadele majadele / Elari Udam ; intervjueerinud Margit Mutso ; kommenteerinud Peeter Pere, Oliver Orro, Jaak Huimerind

    Index Scriptorium Estoniae

    Udam, Elari, 1968-

    2011-01-01

    Vabade CO₂ kvootide müügist laekunud raha eest renoveeritakse energiatõhusaks 480 Eesti hoonet. Projekti juhib Riigi Kinnisvara AS. Teemat selgitab RKASi juhatuse liige ja haldusdirektor Elari Udam, kommenteerivad Eesti Arhitektide Liidu esimees Peeter Pere, aseesimees Jaak Huimerind ja arhitektuuriajaloolane Oliver Orro

  19. CO₂ müük on taastuvenergia toetuse kärpe tõttu löögi all / Raimo Poom

    Index Scriptorium Estoniae

    Poom, Raimo

    2010-01-01

    Austriale CO₂ saastekvootide müügist saadud raha peaks Eesti kasutama kohalike katlamajade tootmise tänapäevastamiseks ja tõhustamiseks. Huvi saadud raha kasutamise vastu on aga järsult vähenenud, selle peapõhjuseks usutakse olevat taastuvenergia toetuste tuleviku ümber valitsev segadus

  20. Avalikustamiskohustuse rikkumine Eesti väärtpaberituruõiguses : tsiviilõiguslikud kaitsevahendid / Meelis Hint

    Index Scriptorium Estoniae

    Hint, Meelis, 1981-

    2003-01-01

    Väärtpaberite avalikustamiskohustusest, tehingu tühistamisest, kahju hüvitamisest, väärtpaberite müügist, kahju hüvitamisest rikkumiste korral ja tehingu tühistamisest väärtpaberite järelturul

  1. Case report

    African Journals Online (AJOL)

    ebutamanya

    2015-10-20

    Oct 20, 2015 ... undefined malignant factors as acknowledged in the 2002 consensus guidelines [3]. These undetermined factors have also instructed the wordings of the guidelines to highlight that GIST is categorized in risk groups, further emphasizing that no lesion is definitely labeled as “benign” [3]. The therapeutic ...

  2. Imatinib as the first and only treatment in Europe for adult patients at significant risk of relapse following gastrointestinal stromal tumor removal

    Science.gov (United States)

    Duffaud, F; Salas, S; Huyn, T; Deville, JL

    2010-01-01

    Mutations of the KIT gene are the molecular hallmark of most gastrointestinal stromal tumors (GISTs). GIST has become a model for targeted treatment of solid tumors, imatinib becoming the standard first-line treatment of these tumors in the advanced/metastatic phase. Because of the efficacy of imatinib treatment in the advanced setting, its role following resection of a primary non-metastatic GIST was investigated. The recently published phase III, double-blind, placebo-controlled, multicenter ACOSOG Z9001 study showed that adjuvant therapy is safe, and significantly improves recurrence-free survival compared to placebo when given after resection. To what extent imatinib will improve overall survival has yet to be answered. What is clear is that high-risk GIST patients definitely need adjuvant therapy, and that 1 year of imatinib is not enough for the patients who do need it. The questions of optimal duration of imatinib treatment in the adjuvant setting, adequate selection of risk patients and effect of imatinib on overall survival are currently being studied. PMID:21694845

  3. Korean Affairs Report No. 321

    Science.gov (United States)

    1983-11-10

    AKHBAR , AL AHRAM and EGYPTIAN GAZETTE and the MENA News Agency of Egupt and Radio Cairo on 12 and 13 October reported the KCNA statement under the...The Indian papers NATIONAL HERALD, PATRIOT, INDIAN EXPRESS, HINDUSTAN TIMES, JAN YUG, ECONOMIC TIMES and FINANCIAL TIMES reported the gist of the

  4. Karupoeg Puhh aitab noori piiritagustele õpingutele / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2004-01-01

    Heategevuskampaania "Puhh saadab sõbrad õppima" raames müüakse karupoeg Puhhi ja teiste raamatutegelaste piltidega kaarte, mille müügist laekuv tulu läheb rahvusvahelise õpilasvahetusega tegeleva organisatsiooni Youth For Understanding Eesti toetusfondi

  5. Academic Freedom and Indentured Students

    Science.gov (United States)

    Williams, Jeffrey J.

    2012-01-01

    Discussion of academic freedom usually focuses on faculty, and it usually refers to speech. That is the gist of the 1915 "General Report of the Committee on Academic Freedom and Academic Tenure," appearing in the inaugural AAUP "Bulletin" as a kind of mission statement. Given the conditions of the American system of higher education--decentralized…

  6. The Errors of Feynman and Hibbs

    Indian Academy of Sciences (India)

    rors simply because he was so smart. He would write down equations that got to the gist of the difficult ... work at a level somewhat below Feynman's, these fac- tors and limits and so forth are not obvious, and their ... an interview with Hibbs in which he said he's working on a book to be titled Quantum Mechanics and Path In-.

  7. Miljonär paneb Ridalas lepalego kokku / Kaire Talviste

    Index Scriptorium Estoniae

    Talviste, Kaire, 1979-

    2003-01-01

    Ridala vallas Panga külas mustast lepast saunatarbeid ja köögitarvikuid meisterdav ettevõtja Gallo Trei kuulus Sylvesteri aktsionäride hulka, aktsiate müügist saadud raha investeeris ta oma ettevõttesse OÜ Trei Puidukaubad. Vt. samas: Sylvesteri müük. Kommenteerib Toomas Schmidt

  8. Linguistic resources and strategies used in multilingual ...

    African Journals Online (AJOL)

    infrastructure, larger patients base and more staff than its counterpart, (HC-2), which is smaller and has a smaller patient and ... staff members, particularly doctors, have a variety of linguistic repertoires and cultural .... consultation. Some can use odd words that they have picked up, others felt that they could follow the gist of.

  9. Alkohol ja majandus / Marje Josing

    Index Scriptorium Estoniae

    Josing, Marje, 1959-

    2003-01-01

    Ilmunud ka: Delovõje Vedomosti 30. juuli lk. 8. Alkoholi tootmisest, tarbimisest, müügist Eestis. IMD riikide uuringust, kus ettevõtjad annavad hinnangu, kuivõrd alkoholiprobleemid segavad ettevõttes tööd. Diagrammid. Tabelid

  10. Gastrointestinal stromal tumor: role of spiral CT in diagnosis and evaluation of treatment with STI571

    International Nuclear Information System (INIS)

    Hu Jiawang; Zhou Linjiang; Wei Jiangong

    2011-01-01

    Objective: To investigate the CT appearance of gastrointestinal stromal tumors (GISTs) after oral imatinib mesylate (STI571) treatment. Methods: CT scans of 58 cases of GISTs proven by histology and immunohistochemistry were retrospectively analyzed. Dynamic contrast-enhanced CT of 8 patients after STI571 treatment was also evaluated. Results: The tumors originated from the stomach (n=28), small intestine (n=12), duodenum (n=6), colon (n=5), rectum (n=4), mesentery (n=2), and esophagus (n=2). Small GISTs appeared as round or oval, endo- or exophytic masses with well-defined margins and homogeneous contrast enhancement. Large lesions were often irregular infiltrative exophytic masses with heterogeneous enhancement. Ulceration, fistulization and neovascularity can be seen within the larger tumors. CT scans of 5 patients with good treatment response showed rapid transition form a heterogeneously hyper-attenuating pattern to homogeneously hypo-attenuating pattern with resolution of the enhancing tumor nodules and decreased tumor neovascularity. In 3 poor responders, CT showed enlarging or new enhancing nodules within the treated hypo-attenuating tumor, new lesions or metastasis outside the primary tumor. Conclusion: CT can demonstrate changes resulting from treatment of GISTs. It is valuable for guiding and assessing treatment response to STI571. (authors)

  11. Bleeding gastrointestinal stromal tumour of the stomach complicated ...

    African Journals Online (AJOL)

    Inferior vena cava filter insertion was not possible due to non-availability. Coexistence of DVT needing anticoagulation and bleeding gastric GIST requiring urgent resection presented a management dilemna. Despite the risk, the patient was taken for an emergency tumor resection primarily to stop the bleeding and facilitate ...

  12. A Synchronization Account of False Recognition

    Science.gov (United States)

    Johns, Brendan T.; Jones, Michael N.; Mewhort, Douglas J. K.

    2012-01-01

    We describe a computational model to explain a variety of results in both standard and false recognition. A key attribute of the model is that it uses plausible semantic representations for words, built through exposure to a linguistic corpus. A study list is encoded in the model as a gist trace, similar to the proposal of fuzzy trace theory…

  13. Involvement of Bmi-1 gene in the development of gastrointestinal stromal tumor by regulating p16Ink4A/p14ARF gene expressions: An in vivo and in vitro study.

    Science.gov (United States)

    Wang, Jiang-Li; Wu, Jiang-Hong; Hong, Cai; Wang, Ya-Nong; Zhou, Ye; Long, Zi-Wen; Zhou, Ying; Qin, Hai-Shu

    2017-12-01

    This study was conducted in order to explore the role that Bmi-1 plays during the development of a gastrointestinal stromal tumor (GIST) by regulation of the p16 Ink4A and p14 ARF expressions. Eighty-six patients diagnosed with GIST were selected to take part in this experiment. The Bmi-1 protein expressions in GIST and adjacent normal tissues were detected using immunohistochemistry and further analyzed by using photodensitometry. To monitor and track the progression of the GIST, a 3-year follow-up was conducted for all affected patients. After cell transfection, the GIST cells were assigned into the control group (without transfection), the negative control (NC) group (transfected with Bmi-1-Scramble plasmid), and the Bmi-1 shRNA group (transfected with the pcDNA3.1-Bmi-1 shRNA plasmid). Protein and mRNA expressions collected from Bmi-1, p16 lnk4A , P14 ARF , cyclin D1, and CDK4 were measured using both the RT-qPCR and western blotting methods Cell senescence was assessed and obtained by using the β-Galactosidase (β-Gal) activity assay. The use of a Soft agar colony formation assay and CCK-8 assay were performed in order to detect the cell growth and subsequent proliferation. Cell invasion and migration were analyzed using the Transwell assay and scratch test. Bmi-1 in the GIST tissues was found to be significantly higher and the p16 lnk4A and P14 ARF expressions were lower than those in the adjacent normal tissues. Bmi-1 was negatively correlated with p16 lnk4A and P14 ARF expressions according to the correlation analysis. Bmi-1 expression was associated with the TNM stage, postoperative recurrence, metastasis, tumor size, and the 5-year survival rate. Area under ROC curve was calculated at 0.884, and sensitivity, specificity, and accuracy of Bmi-1 predicting the GIST were 67.44%, 97.67%, and 65.12%, respectively. Patients exhibiting a high Bmi-1 expression in the GIST tissues had lower survival rates than those with low Bmi-1 expression. In comparison with

  14. Endo-laparoscopic rendezvous approach for pericardia with gastric posterior wall of gastrointestinal stromal tumor: analysis of 52 consecutive cases.

    Science.gov (United States)

    Ding, Po; Zhao, Yongjie

    2014-12-01

    Gastrointestinal stromal tumor (GIST) is the most common mesenchymal tumor in the gastrointestinal tract and most frequently developed in the stomach, and surgical therapy is limited on removal of the tumor lesion. The aim of this study was to investigate the clinical values of endo-laparoscopic rendezvous approach for pericardial GISTs within gastric posterior wall. Surgical outcome and clinical data of 52 patients with pericardial GISTs within gastric posterior wall treated at Tianjin Peoples' Hospital from January 2004 to October 2013 were analyzed. Endo-laparoscopic rendezvous approach was used as an operative procedure for tumor resection ranged from 10 to 50 mm. Endoscopic ultrasound, computed tomography and microscopic findings all certified the gastric spindle type GIST locating in the submucosa to muscle proper. Endo-laparoscopic rendezvous approach was attempted in 52 patients (male/female: 31/21) with median age of 51 years (25-71 years). The median operating time was 80 min (range: 40-120 min) and median intra-operative blood loss was 26 ml (range: 10-50 ml). The median hospital stay was 5 days (range: 4-6 days), while the median tumor size was 25 mm (range: 7-50 mm). All operative margins were clear. There were no recurrences or metastases of all patients in a median follow-up of 24 months (range: 6-36 months). Endo-laparoscopic rendezvous approach is considered to represent the next revolution in surgery. The new technique is reliable and effective in clinical application, due to the advantages of accurate and quick localization for pericardial GIST within gastric posterior wall.

  15. Clinicians' perceptions of the benefits and harms of prostate and colorectal cancer screening.

    Science.gov (United States)

    Elstad, Emily A; Sutkowi-Hemstreet, Anne; Sheridan, Stacey L; Vu, Maihan; Harris, Russell; Reyna, Valerie F; Rini, Christine; Earp, Jo Anne; Brewer, Noel T

    2015-05-01

    Clinicians' perceptions of screening benefits and harms influence their recommendations, which in turn shape patients' screening decisions. We sought to understand clinicians' perceptions of the benefits and harms of cancer screening by comparing 2 screening tests that differ in their balance of potential benefits to harms: colonoscopy, which results in net benefit for many adults, and prostate-specific antigen (PSA) testing, which may do more harm than good. In this cross-sectional study, 126 clinicians at 24 family/internal medicine practices completed surveys in which they listed and rated the magnitude of colonoscopy and PSA testing benefits and harms for a hypothetical 70-year-old male patient and then estimated the likelihood that these tests would cause harm and lengthen the life of 100 similar men in the next 10 years. We tested the hypothesis that the availability heuristic would explain the association of screening test to perceived likelihood of benefit/harm and a competing hypothesis that clinicians' gist of screening tests as good or bad would mediate this association. Clinicians perceived PSA testing to have a greater likelihood of harm and a lower likelihood of lengthening life relative to colonoscopy. Consistent with our gist hypothesis, these associations were mediated by clinicians' gist of screening (balance of perceived benefits to perceived harms). Generalizability beyond academic clinicians remains to be established. Targeting clinicians' gist of screening, for example through graphical displays that allow clinicians to make gist-based relative magnitude comparisons, may influence their risk perception and possibly reduce overrecommendation of screening. © The Author(s) 2015.

  16. Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors

    Directory of Open Access Journals (Sweden)

    Hajime Orita

    2014-01-01

    Full Text Available Background. Despite complete resection of gastrointestinal stromal tumors (GIST, recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as a prognostic biomarker for GIST. In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model. Object. Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included. The majority of tumors originated in the stomach (38 cases, as well as small intestine (6 cases and rectum (1 case. Method. (1 We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses. (2 The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry. Pfetin. We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker. Results. There were 7 cases of recurrences. (1 By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence. (2 Pfetin-negative cases were significantly related to recurrence (P = 0.002. Conclusions. This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST. Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy.

  17. Clinical practice and outcomes in advanced gastrointestinal stromal tumor: Experience from an Indian tertiary care center

    Directory of Open Access Journals (Sweden)

    Subhadeep Bose

    2017-01-01

    Full Text Available Background: Management of advanced Gastrointestinal stromal tumors (GIST has been revolutionized with the use of Imatinib guided by mutation analysis. Data from India remains scarce. Materials and Methods: Patients with metastatic GIST who were treated at Department of Gastro-intestinal & Hepaticopancreaticobiliary Oncology Unit at Tata Memorial Hospital, Mumbai between December, 2004 and December 2015 were included in the analysis. Clinical and radiological data was retrieved from stored medical records and charts. Results: A total of 83 patients with metastatic GIST were available for analysis. Median age was 54 years with a 3:1 male predominance. Stomach was the most common site of primary with liver being the most common site of metastasis. c-Kit mutation analysis results were available for 44 patients with exon 11 mutant being the most common mutation. With a median follow up of 33 months, the 10 years estimated progression free and overall survival (OS was 18% and 51% respectively. Overall response rate to first line imatinib was 37.6% and estimated 3 years OS to first line therapy was significantly better for Exon 11 mutated patients (p=0.016. 34 patients received second line therapy in the form of either sunitinib, pazopanib or increased dose imatinib with a clinical benefit rate of 73.5%. C-Kit mutated patients had a better median OS compared to non mutated patients. Conclusions: GIST diagnosed and treated in the Indian subcontinent appears to show improved outcomes. The importance of c-Kit mutation analysis in determining the prognosis and outcomes of patients with advanced GIST is emphasized.

  18. Geographic Information Systems-Transportation ISTEA management systems server-net prototype pooled fund study: Phase B summary

    Energy Technology Data Exchange (ETDEWEB)

    Espinoza, J. Jr.; Dean, C.D.; Armstrong, H.M. [and others

    1997-06-01

    The Geographic Information System-Transportation (GIS-T) ISTEA Management Systems Server Net Prototype Pooled Fund Study represents the first national cooperative effort in the transportation industry to address the management and monitoring systems as well as the statewide and metropolitan transportation planning requirements of the Intermodal Surface Transportation Efficiency Act of 1991 (ISTEA). The Study was initiated in November 1993 through the Alliance for Transportation Research and under the leadership of the New Mexico State Highway and Transportation Department. Sandia National Laboratories, an Alliance partner, and Geographic Paradigm Computing. Inc. provided technical leadership for the project. In 1992, the Alliance for Transportation Research, the New Mexico State Highway and Transportation Department, Sandia National Laboratories, and Geographic Paradigm Computing, Inc., proposed a comprehensive research agenda for GIS-T. That program outlined a national effort to synthesize new transportation policy initiatives (e.g., management systems and Intelligent Transportation Systems) with the GIS-T server net ideas contained in the NCHRP project {open_quotes}Adaptation of GIS to Transportation{close_quotes}. After much consultation with state, federal, and private interests, a project proposal based on this agenda was prepared and resulted in this Study. The general objective of the Study was to develop GIS-T server net prototypes supporting the ISTEA requirements for transportation planning and management and monitoring systems. This objective can be further qualified to: (1) Create integrated information system architectures and design requirements encompassing transportation planning activities and data. (2) Encourage the development of functional GIS-T server net prototypes. (3) Demonstrate multiple information systems implemented in a server net environment.

  19. Texture-based classification of different gastric tumors at contrast-enhanced CT

    Energy Technology Data Exchange (ETDEWEB)

    Ba-Ssalamah, Ahmed, E-mail: ahmed.ba-ssalamah@meduniwien.ac.at [Department of Radiology, Medical University of Vienna (Austria); Muin, Dina; Schernthaner, Ruediger; Kulinna-Cosentini, Christiana; Bastati, Nina [Department of Radiology, Medical University of Vienna (Austria); Stift, Judith [Department of Pathology, Medical University of Vienna (Austria); Gore, Richard [Department of Radiology, University of Chicago Pritzker School of Medicine, Chicago, IL (United States); Mayerhoefer, Marius E. [Department of Radiology, Medical University of Vienna (Austria)

    2013-10-01

    Purpose: To determine the feasibility of texture analysis for the classification of gastric adenocarcinoma, lymphoma, and gastrointestinal stromal tumors on contrast-enhanced hydrodynamic-MDCT images. Materials and methods: The arterial phase scans of 47 patients with adenocarcinoma (AC) and a histologic tumor grade of [AC-G1, n = 4, G1, n = 4; AC-G2, n = 7; AC-G3, n = 16]; GIST, n = 15; and lymphoma, n = 5, and the venous phase scans of 48 patients with AC-G1, n = 3; AC-G2, n = 6; AC-G3, n = 14; GIST, n = 17; lymphoma, n = 8, were retrospectively reviewed. Based on regions of interest, texture analysis was performed, and features derived from the gray-level histogram, run-length and co-occurrence matrix, absolute gradient, autoregressive model, and wavelet transform were calculated. Fisher coefficients, probability of classification error, average correlation coefficients, and mutual information coefficients were used to create combinations of texture features that were optimized for tumor differentiation. Linear discriminant analysis in combination with a k-nearest neighbor classifier was used for tumor classification. Results: On arterial-phase scans, texture-based lesion classification was highly successful in differentiating between AC and lymphoma, and GIST and lymphoma, with misclassification rates of 3.1% and 0%, respectively. On venous-phase scans, texture-based classification was slightly less successful for AC vs. lymphoma (9.7% misclassification) and GIST vs. lymphoma (8% misclassification), but enabled the differentiation between AC and GIST (10% misclassification), and between the different grades of AC (4.4% misclassification). No texture feature combination was able to adequately distinguish between all three tumor types. Conclusion: Classification of different gastric tumors based on textural information may aid radiologists in establishing the correct diagnosis, at least in cases where the differential diagnosis can be narrowed down to two

  20. Texture-based classification of different gastric tumors at contrast-enhanced CT

    International Nuclear Information System (INIS)

    Ba-Ssalamah, Ahmed; Muin, Dina; Schernthaner, Ruediger; Kulinna-Cosentini, Christiana; Bastati, Nina; Stift, Judith; Gore, Richard; Mayerhoefer, Marius E.

    2013-01-01

    Purpose: To determine the feasibility of texture analysis for the classification of gastric adenocarcinoma, lymphoma, and gastrointestinal stromal tumors on contrast-enhanced hydrodynamic-MDCT images. Materials and methods: The arterial phase scans of 47 patients with adenocarcinoma (AC) and a histologic tumor grade of [AC-G1, n = 4, G1, n = 4; AC-G2, n = 7; AC-G3, n = 16]; GIST, n = 15; and lymphoma, n = 5, and the venous phase scans of 48 patients with AC-G1, n = 3; AC-G2, n = 6; AC-G3, n = 14; GIST, n = 17; lymphoma, n = 8, were retrospectively reviewed. Based on regions of interest, texture analysis was performed, and features derived from the gray-level histogram, run-length and co-occurrence matrix, absolute gradient, autoregressive model, and wavelet transform were calculated. Fisher coefficients, probability of classification error, average correlation coefficients, and mutual information coefficients were used to create combinations of texture features that were optimized for tumor differentiation. Linear discriminant analysis in combination with a k-nearest neighbor classifier was used for tumor classification. Results: On arterial-phase scans, texture-based lesion classification was highly successful in differentiating between AC and lymphoma, and GIST and lymphoma, with misclassification rates of 3.1% and 0%, respectively. On venous-phase scans, texture-based classification was slightly less successful for AC vs. lymphoma (9.7% misclassification) and GIST vs. lymphoma (8% misclassification), but enabled the differentiation between AC and GIST (10% misclassification), and between the different grades of AC (4.4% misclassification). No texture feature combination was able to adequately distinguish between all three tumor types. Conclusion: Classification of different gastric tumors based on textural information may aid radiologists in establishing the correct diagnosis, at least in cases where the differential diagnosis can be narrowed down to two

  1. Gastrointestinal stromal tumour of the duodenum in childhood: a rare case report

    International Nuclear Information System (INIS)

    Chiarugi, Massimo; Galatioto, Christian; Lippolis, Piero; Zocco, Giuseppe; Seccia, Massimo

    2007-01-01

    Gastrointestinal stromal tumours (GISTs) are uncommon primary mesenchymal tumours of the gastrointestinal tract mostly observed in the adults. Duodenal GISTs are relatively rare in adults and it should be regarded as exceptional in childhood. In young patients duodenal GISTs may be a source of potentially lethal haemorrhage and this adds diagnostic and therapeutic dilemmas to the concern about the long-term outcome. A 14-year-old boy was referred to our hospital with severe anaemia due to recurrent episodes of upper gastrointestinal haemorrhage. Endoscopy, small bowel series, scintigraphy and video capsule endoscopy previously done elsewhere were negative. Shortly after the admission, the patient underwent emergency surgery for severe recurrence of the bleeding. At surgery, a 4 cm solid mass arising from the wall of the fourth portion of the duodenum was identified. The invasion and the erosion of the duodenal mucosa was confirmed by intra-operative pushed duodenoscopy. The mass was resected by a full-thickness duodenal wall excision with adequate grossly free margins. Immunohistochemical analysis of the specimen revealed to be positive for CD117 (c-KIT protein) consistent with a diagnosis of GIST. The number of mitoses was < 5/50 HPF. Mutational analysis for c-KIT/PDGFRA tyrosine kinase receptor genes resulted in a wildtype pattern. The patient had an uneventful course and he has remained disease-free during two years of follow-up. Duodenal GISTs in children are very rare and may present with massive bleeding. Cure can be achieved by complete surgical resection, but even in the low-aggressive tumours the long-term outcome may be unpredictable

  2. Ovários policísticos: critérios hemodinâmicos

    OpenAIRE

    Ávila,Márcio Augusto Pinto de; Murta,Carlos Geraldo Viana

    2001-01-01

    O advento da ultra-sonografia endovaginal de alta resolução abriu novas áreas de pesquisa nos ovários policísticos. O conhecimento da hemodinâmica ovariana é fundamental para o entendimento do comportamento fisiopatológico dos ovários policísticos. Os autores tecem considerações sobre a possibilidade da utilização do Doppler colorido na melhor definição dos ovários policísticos. Os dados sugerem que o aumento da vascularidade e a diminuição da resistência dos vasos do estroma ovariano, assim ...

  3. Distrofia corneal granular

    Directory of Open Access Journals (Sweden)

    Alexeide de la C Castillo Pérez

    Full Text Available Las distrofias corneales constituyen un conjunto de enfermedades que presentan, en su mayoría, una baja incidencia y se caracterizan por acúmulo de material hialino o amiloide que disminuyen la transparencia corneal. La distrofia granular es una enfermedad autosómica dominante que presenta opacidades grises en el estroma superficial central de la córnea y se hacen visibles en la primera y segunda décadas de la vida, lo que provoca disminución de la visión más significativa cerca de los 40 años de edad. Presentamos dos casos clínicos de distrofia granular en pacientes hermanos de diferentes sexos, quienes acudieron a la consulta y refirieron visión nublada. El estudio de la historia familiar nos ayuda en el correcto diagnóstico y la biomicroscopia constituye el elemento más importante.

  4. Tumor de células esteroideas de ovario: Reporte de un caso y revisión de la literatura

    Directory of Open Access Journals (Sweden)

    Pedro Aguilar-Ramos

    2011-01-01

    Full Text Available El tumor de células esteroideas de ovario es una neoplasia poco frecuente que se origina del estroma o de los cordones sexuales y es potencialmente maligno. La mayoría de estos tumores producen hormonas esteroides siendo la testosterona la que se eleva frecuentemente. Se presenta el caso de una paciente de 30 años que presentó signos de virilización asociado a masa pélvica, ascitis e incremento de la testosterona. Fue operada y sometida a estadiaje de ovario. El resultado del estudio anatomopatológico fue tumor de células esteroideas. Una revisión de los aspectos clínicos, diagnósticos y terapéuticos de estos tumores, es presentada. (Rev Med Hered 2011;22:38-41.

  5. Suplementação de óleo de peixe em câncer colorretal

    OpenAIRE

    Mocellin, Michel Carlos

    2012-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde. Programa de Pós-Graduação em Nutrição Células e mediadores inflamatórios são componentes essenciais do microambiente tumoral. A inflamação no câncer é sustentada pela produção de citocinas e quimiocinas pelas células imunes, tumorais e do estroma a partir da ativação de fatores de transcrição nestas mesmas células em resposta a estímulos de iniciação e promoção tumoral, ou ainda, de controle da pr...

  6. Queratitis causada por Paecilomyces lilacinus. Reporte de un caso

    Directory of Open Access Journals (Sweden)

    Alejandro del Castillo Ruiz

    2016-01-01

    Conclusiones: La queratitis micótica es una infección corneal muy seria, de evolución tórpida, que puede causar ceguera. Comúnmente se desarrolla en pacientes después de un trauma o en aquellos con una superficie corneal comprometida. Voriconazol se ha referido como un fármaco útil para el tratamiento de úlceras corneales causadas por Paecilomyces lilacinus con muy buena penetración a estroma, acuoso y vítreo por vía oral y tópica. Un diagnóstico y tratamiento oportunos fueron esenciales en este caso de queratitis micótica para su resolución.

  7. Cryptosporidium spp. em furão (Mustela putorius furo) no sul do Brasil

    OpenAIRE

    Fanfa, Vinicius da Rosa; Farret, Matheus Hillard; Silva, Aleksandro Schafer da; Monteiro, Silvia Gonzalez

    2010-01-01

    http://dx.doi.org/10.5007/2175-7925.2010v23n1p225 Este trabalho visou avaliar o parasitismo gastrintestinal em furão (Mustela putorius furo) mantido em cativeiro no sul do Brasil. Foram analisadas fezes de dois furões, macho e fêmea, com três anos de idade, através das técnicas de exame direto, centrífugo-flutuação com sulfato de zinco e a coloração pelo método de Kinyoun para pesquisa de parasitos. Nas amostras constatou-se a presença de oocistos de Cryptosporidium spp. Este caso refere-...

  8. Antifungigrama para comprovar o potencial de ação dos extratos vegetais hidroglicólicos sobre Candida sp. (Berkhout)

    OpenAIRE

    Glehn,E.A.V.; Rodrigues,G.P.S.

    2012-01-01

    A candidíase vaginal é uma doença causada, na maioria das vezes, pelo fungo do gênero Candida sp, que habita o trato gastrintestinal e geniturinário da espécie humana e pode tornar-se patogênico sob determinadas condições. A maioria dos indivíduos desenvolve defesas imunológicas que impedem a proliferação e desenvolvimento de candidíase localizada ou disseminada. Embora a causa exata do aumento de espécies não-albicans seja desconhecida, há evidências de que a própria terapia antifúngica poss...

  9. Isotretinoína: perfis farmacológico, farmacocinético e analítico Isotretinoin: pharmacological, pharmacokinetic and analytical profiles

    Directory of Open Access Journals (Sweden)

    Danielle Guimarães Almeida Diniz

    2002-12-01

    Full Text Available A isotretinoína, quimicamente conhecida como ácido-13-cis-retinóico, faz parte do amplo grupo de compostos relacionados à vitamina A. É empregada particularmente no tratamento da acne cística e nodular e como inibidor da proliferação de células neoplásicas, por exercer efeito regulador sobre a diferenciação celular. Os efeitos adversos envolvendo o uso de isotretinoína estão relacionados à pele e membranas mucosas, sistemas nervoso, músculo esquelético, linfático, gastrintestinal, cardiorespiratório e geniturinário. A isotretinoína é um composto termo e fotossensível e, por assim se apresentar, desperta o interesse pelo estudo de sua estabilidade, empregando-se para isso várias metodologias analíticas como a CLAE, CG, análise térmica, espectroscopia de massa, microcalorimetria, difratometria de raios-X e muitas outras que devem ser selecionadas de acordo com o interesse do pesquisador.Isotretinoin, or 13-cis-retinoic acid, is one of the vitamin A related compounds. Isotretinoin is used for the treatment of severe cystic acne and also shows inhibitory activity over the proliferation of neoplasic cells, due to its efficiency in regulating cell diferentiation. Side effects are related to skin and mucous membranes, central nervous system, muscles, lymphatic, gastrintestinal, pulmonary and genitourinary systems. Isotretinoin is a highly thermal and photolabile compound. Stability studies require several analytical methods such as HPLC, GC, thermal analysis, mass spectrometry, microcalorimetry and X-Ray difratometry.

  10. Modelo do fluxo biológico do fósforo de fontes de fosfato em suínos, usando o 32P como marcador Model of the biological flow of phosphorus from phosphate sources in pig, using 32P as marker

    Directory of Open Access Journals (Sweden)

    João Batista Lopes

    2001-02-01

    Full Text Available A pesquisa destinou-se a simular modelos matemáticos relacionados ao fluxo de fósforo (P, partindo-se das hipóteses de que o P endógeno do trato digestivo foi absorvido na mesma proporção do P alimentar e o fluxo de entrada e de saída desse mineral nos compartimentos foi constante. Foram avaliadas as variáveis absorção, retenção, P endógeno que retorna ao trato gastrintestinal, P dietético absorvido, incorporação, reabsorção e balanço de P no osso e nos tecidos moles e P proveniente do osso, dos tecidos moles e do total absorvido, que retorna ao trato gastrintestinal, em suínos em crescimento, alimentados com dietas contendo P de diferentes fontes de fosfato. O modelo usado foi determinístico e compartimental, em que o trato gastrintestinal (C1, os ossos (C2 e os tecidos moles, fígado, coração, rim e músculo, estudados em conjunto (C3, representaram os compartimentos. Foram utilizadas informações sobre metabolismo e cinética do fósforo em tecidos, obtidas pela técnica da diluição isotópica. Constatou-se que as hipóteses estabelecidas no modelo estão coerentes e os valores obtidos se ajustam ao fluxo do fósforo em suínos; as variáveis P consumido, P endógeno, que retorna ao trato gastrintestinal, P absorvido de origem dietética, retenção de P, incorporação, reabsorção e balanço de P do osso e dos demais tecidos e fração de P do total absorvido que retorna ao trato gastrintestinal não foram influenciadas pelas fontes suplementares de fósforo; a origem do fósforo dietético pode interferir na distribuição do P nos tecidos, após o processo de absorção desse mineral; e o P proveniente do absorvido que retorna ao trato gastrintestinal foi proporcional ao P consumido.The experiment was designed to simulate the mathematical models that relate to the phophorus (P flow, considering the hypotheses that the endogenous phosphorus from digestive tract was absorbed in the same proportion of the dietary

  11. Tríada de Carney incompleta e hipertensión arterial en una mujer joven Incomplete Carney’s triad and arterial hypertension in a young woman

    Directory of Open Access Journals (Sweden)

    Alberto Allievi

    2006-02-01

    Full Text Available Se presenta una el caso de paciente joven, con tríada de Carney incompleta que cursa hipertensión arterial de dos años de evolución y anemia ferropénica grave por pérdida crónica de sangre por tubo digestivo, con tumores gástricos múltiples y paraganglioma pararrenal. No presenta aún desarrollo de condromas pulmonares visibles por tomografía axial computada. En nuestra paciente el paraganglioma no resultó funcionante. Resaltamos que la presencia de tumores gástricos múltiples en un adulto joven debe sugerir la posibilidad de tumores estromales (GIST, cuyo diagnóstico por biopsia endoscópica es difícil debido a su localización profunda, situada en las capas musculares de la pared gástrica. Asimismo queremos remarcar la importancia de las técnicas de marcación descriptas para el diagnóstico preciso. El seguimiento debe ser constante dado el pronóstico incierto de estos tumores. Los condromas pulmonares pueden aparecer años después de la resección del GIST y ser confundidos con metástasis del GIST.The case of young woman with arterial hypertension diagnosed two years before, is here presented; she had a ferropenic anemia caused by digestive loss of blood. Multiple gastric tumors and pararenal non functioning paraganglioma were found. No chondromas were detected. An incomplete Carney’s Triad was diagnosed. We remark that multiple gastric tumors in a young adult suggest the possibility of gastrointestinal stromal tumors (GIST Endoscopic biopsy frequently is not effective because these tumors are deep placed in the muscular gastric layers. The importance of specific techniques for a positive diagnosis are emphasized. Continuous follow up is needed because these tumors have uncertain prognosis. Lung chondromas may appear years later after the GIST was removed and might be confused with GIST metastases.

  12. Grid inhomogeneous solvation theory: hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril.

    Science.gov (United States)

    Nguyen, Crystal N; Young, Tom Kurtzman; Gilson, Michael K

    2012-07-28

    The displacement of perturbed water upon binding is believed to play a critical role in the thermodynamics of biomolecular recognition, but it is nontrivial to unambiguously define and answer questions about this process. We address this issue by introducing grid inhomogeneous solvation theory (GIST), which discretizes the equations of inhomogeneous solvation theory (IST) onto a three-dimensional grid situated in the region of interest around a solute molecule or complex. Snapshots from explicit solvent simulations are used to estimate localized solvation entropies, energies, and free energies associated with the grid boxes, or voxels, and properly summing these thermodynamic quantities over voxels yields information about hydration thermodynamics. GIST thus provides a smoothly varying representation of water properties as a function of position, rather than focusing on hydration sites where solvent is present at high density. It therefore accounts for full or partial displacement of water from sites that are highly occupied by water, as well as for partly occupied and water-depleted regions around the solute. GIST can also provide a well-defined estimate of the solvation free energy and therefore enables a rigorous end-states analysis of binding. For example, one may not only use a first GIST calculation to project the thermodynamic consequences of displacing water from the surface of a receptor by a ligand, but also account, in a second GIST calculation, for the thermodynamics of subsequent solvent reorganization around the bound complex. In the present study, a first GIST analysis of the molecular host cucurbit[7]uril is found to yield a rich picture of hydration structure and thermodynamics in and around this miniature receptor. One of the most striking results is the observation of a toroidal region of high water density at the center of the host's nonpolar cavity. Despite its high density, the water in this toroidal region is disfavored energetically and

  13. [Positron emission tomography with fluorine-deoxyglucose in sarcomas and non-sarcoma non-epithelial tumors].

    Science.gov (United States)

    Massardo, Teresa; Jofré, María Josefina; Sierralta, María Paulina; Canessa, José; Castro, Gabriel; Berrocal, Isabel; Gallegos, Iván

    2012-09-01

    The usefulness of positron emission tomography (PET) with fluorine-deoxyglucose (FDG) in sarcomas and non-sarcoma non-epithelial (NSNE) tumors is not clearly defined. To report a Chilean experience with NSNE tumors evaluated using PET with FDG. Retrospective review of the database of a PET laboratory. Demographic data, indications and metabolic findings were compared with conventional imaging in 88 adults and children with diverse bone and soft tissue sarcomas as well as 24 gastrointestinal stromal tumors (GIST), 6 pleural malignant mesotheliomas in adults, and 9 medulloblastomas in children. FDG showed good concordance with conventional imaging in NSNE tumors. It was helpful for staging, restaging, follow-up after treatment and for the detection of new not previously suspected lesions. PET with FDG could have a prognostic role and help in patient management, mainly in musculoskeletal and high grade or less differentiated sarcomas. In GIST, it was a good tool for immunotherapy control.

  14. Positron emission tomography with fluorine-deoxyglucose in sarcomas and non-sarcoma non-epithelial tumors; Utilidad del estudio PET con FDG en la evaluacion de sarcomas de diverso origen y de tumores no sarcoma-no epiteliales

    Energy Technology Data Exchange (ETDEWEB)

    Massardo, Teresa [Seccion Medicina Nuclear, Departamento de Medicina, Hospital Clinico Universidad de Chile, Santiago (Chile); Jofre, Maria Josefina; Sierralta, Maria Paulina; Canessa, Jose [Centro PET de imagenes moleculares, Hospital Militar de Santiago, Santiago (Chile); Castro, Gabriel; Berrocal, Isabel [Seccion Medicina Nuclear, Departamento de Medicina, Hospital Clinico Universidad de Chile, Santiago (Chile); Gallegos, Ivan [Departamento Anatomia Patologica, Hospital Clinico Universidad de Chile, Santiago (Chile)

    2012-07-01

    Background: The usefulness of positron emission tomography (PET) with fluorine-deoxyglucose (FDG) in sarcomas and non-sarcoma non-epithelial (NSNE) tumors is not clearly defined. Aim: To report a Chilean experience with NSNE tumors evaluated using PET with FDG. Material and Methods: Retrospective review of the database of a PET laboratory. Demographic data, indications and metabolic findings were compared with conventional imaging in 88 adults and children with diverse bone and soft tissue sarcomas as well as 24 gastrointestinal stromal tumors (GIST), 6 pleural malignant mesotheliomas in adults, and 9 medulloblastomas in children. Results: FDG showed good concordance with conventional imaging in NSNE tumors. It was helpful for staging, restaging, follow-up after treatment and for the detection of new not previously suspected lesions. Conclusions: PET with FDG could have a prognostic role and help in patient management, mainly in musculoskeletal and high grade or less differentiated sarcomas. In GIST, it was a good tool for immunotherapy control.

  15. Positron emission tomography with fluorine-deoxyglucose in sarcomas and non-sarcoma non-epithelial tumors

    International Nuclear Information System (INIS)

    Massardo, Teresa; Jofre, Maria Josefina; Sierralta, Maria Paulina; Canessa, Jose; Castro, Gabriel; Berrocal, Isabel; Gallegos, Ivan

    2012-01-01

    Background: The usefulness of positron emission tomography (PET) with fluorine-deoxyglucose (FDG) in sarcomas and non-sarcoma non-epithelial (NSNE) tumors is not clearly defined. Aim: To report a Chilean experience with NSNE tumors evaluated using PET with FDG. Material and Methods: Retrospective review of the database of a PET laboratory. Demographic data, indications and metabolic findings were compared with conventional imaging in 88 adults and children with diverse bone and soft tissue sarcomas as well as 24 gastrointestinal stromal tumors (GIST), 6 pleural malignant mesotheliomas in adults, and 9 medulloblastomas in children. Results: FDG showed good concordance with conventional imaging in NSNE tumors. It was helpful for staging, restaging, follow-up after treatment and for the detection of new not previously suspected lesions. Conclusions: PET with FDG could have a prognostic role and help in patient management, mainly in musculoskeletal and high grade or less differentiated sarcomas. In GIST, it was a good tool for immunotherapy control

  16. Summary report of activities under visiting research program in Research Reactor Institute, Kyoto University, second half of 1989

    International Nuclear Information System (INIS)

    1990-07-01

    The Technical Report is published on occasion by summarizing in the form of prompt report the data required at the time of research and experiment, such as the results of the functional test on various experimental facilities, the test results for the articles made for trial, the state of radiation control and waste treatment, the reports of study meetings and so on, or the remarkable results and new methods obtained in research, the discussion on other papers and reports and others in the Research Reactor Institute, Kyoto University. In this report, the gists of 69 studies carried out by using the Research Reactor and 15 studies by using the Kyoto University Critical Assembly are collected. Adoption number, classification, title, the names of reporters and gist are given for each report. (K.I.)

  17. Perivascular Epithelioid Cell Tumor in the Stomach

    Directory of Open Access Journals (Sweden)

    Sun Ah Shin

    2017-07-01

    Full Text Available Perivascular epithelioid cell tumors or PEComas can arise in any location in the body. However, a limited number of cases of gastric PEComa have been reported. We present two cases of gastric PEComas. The first case involved a 62-year-old woman who presented with a 4.2 cm gastric subepithelial mass in the prepyloric antrum, and the second case involved a 67-year-old man with a 5.0 cm mass slightly below the gastroesophageal junction. Microscopic examination revealed that both tumors were composed of perivascular epithelioid cells that were immunoreactive for melanocytic and smooth muscle markers. Prior to surgery, the clinical impression of both tumors was gastrointestinal stromal tumor (GIST, and the second case was erroneously diagnosed as GIST even after microscopic examination. Although gastric PEComa is a very rare neoplasm, it should be considered in the differential diagnosis of gastric submucosal lesions.

  18. Diagnosis of gastrointestinal stromal tumors from minute specimens: cytomorphology, immunohistochemistry, and molecular diagnostic findings.

    Science.gov (United States)

    Layfield, Lester J; Wallander, Michelle L

    2012-06-01

    Gastrointestinal stromal tumors (GIST) are the most common mesenchymal neoplasm arising from the gastrointestinal tract. Workup of these lesions includes morphologic study and immunohistochemical and often molecular diagnostic analysis. Historically, these neoplasms had been included under a number of diagnostic categories including leiomyoma, leiomyosarcoma, schwannoma, and leiomyoblastoma. The lesions that were clearly sarcomatous were difficult to treat and therapeutically refractory to chemotherapeutic agents. Significant progress in our understanding of these neoplasms and our ability to successfully treat them occurred following the discovery that they were immunoreactive for KIT protein and harbored activating mutations in the KIT gene. Many are initially diagnosed by fine-needle aspiration (FNA) but workup may include mutational analysis to help direct therapy. This review outlines a practical approach to the cytologic diagnosis of GISTs and their molecular workup on small specimens obtained by FNA or core biopsy. Copyright © 2012 Wiley Periodicals, Inc.

  19. KIT-negative Gastrointestinal Stromal Tumor in a Child: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Lim, Se Woong; Lee, Young Hwan; Park, Sang Hyeon; Choi, Du young; Choi, Geum Ha [Wonkwang University School of Medicine and Hospital, Iksan (Korea, Republic of)

    2011-01-15

    We report here on the imaging findings of the case of KIT-negative gastrointestinal stromal tumor (GIST) in the stomach of a 12-year-old girl. Radiologic studies revealed the presence of a huge exophytic growing mass that originated from the gastric wall and this mass consisted of solid and cystic components on USG, CT and MR. The cystic regions were mainly located at the periphery of the mass and they were revealed to be myxoid degeneration and hemorrhage on histopathologic examination. The tumor consisted of epithelioid and typical spindle cells and they showed negative immunoreactivity for KIT. Although KIT-negative GISTs are rare, they can be considered in the differential diagnosis when a large heterogeneous extraluminal mass that contains solid portions and various degrees of peripheral cystic regions is observed

  20. Scene incongruity and attention.

    Science.gov (United States)

    Mack, Arien; Clarke, Jason; Erol, Muge; Bert, John

    2017-02-01

    Does scene incongruity, (a mismatch between scene gist and a semantically incongruent object), capture attention and lead to conscious perception? We explored this question using 4 different procedures: Inattention (Experiment 1), Scene description (Experiment 2), Change detection (Experiment 3), and Iconic Memory (Experiment 4). We found no differences between scene incongruity and scene congruity in Experiments 1, 2, and 4, although in Experiment 3 change detection was faster for scenes containing an incongruent object. We offer an explanation for why the change detection results differ from the results of the other three experiments. In all four experiments, participants invariably failed to report the incongruity and routinely mis-described it by normalizing the incongruent object. None of the results supports the claim that semantic incongruity within a scene invariably captures attention and provide strong evidence of the dominant role of scene gist in determining what is perceived. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Could imatinib replace surgery in esophageal gastrointestinal stromal tumor

    International Nuclear Information System (INIS)

    Al-Salam, Suhail N.; El-Teraifi, Hassan A.; Taha, Mazen S.

    2006-01-01

    Gastrointestinal stromal tumors (GISTs) are cellular spindle, or epithelioid tumors that occur in the stomach, intestine and rarely in the esophagus. A 61-years-old man was complaining of resistant dry cough with dysphagia for one month duration. Upper gastrointestinal tract endoscopic examination showed a polypoid mass 30 cm from the incisors obstructing 50% of the lumen, where multiple biopsies were taken. Magnetic resonance imaging (MRI) showed a mass in the wall of the esophagus extending into the thoracic cavity. Histologically, the stained sections with routine hematoxylin and eosin as well as the immunohistochemical stainsfor CD117, CD34, S100, vimentin and smooth muscle actin confirmed the diagnosis of esophageal GIST. The patient was treated with imatinib 400mg/day. There was a dramatic reduction in the size of the tumor with successful improvement of his symptoms after 2 months of treatment, which was confirmed by reapeated upper GIT endoscopy, and MRI. (author)

  2. Discussion on the methods for calculation release limits for low-level radioactive waste

    International Nuclear Information System (INIS)

    Cao Fengbo; Liu Xiaochao

    2012-01-01

    The release request for low-level radioactive waste are briefly described in this paper. Associating with the conditions of low-level radioactive waste of some radioactive waste processing station, the methods and gist for calculating release limits for low-level radioactive waste with national release limits and annual effective dose limit for the public or the occupation are discussed. Then release limits for the low-level radioactive waste are also proposed. (authors)

  3. Lääs ja süntetismi väljakutsed / Jüri Talvet

    Index Scriptorium Estoniae

    Talvet, Jüri, 1945-

    2002-01-01

    Kokkuvõte "The West and the challenge of synthetism", lk. 1089-1090. Kriitiliselt Lääne kultuuriuuringute diskursustest: eksistentsialism, strukturalism, psühhoanalüüs, poststrukturalism. Essee aluseks on hispaaniakeelne plenaarettekanne rahvusvahelisel kongressil Valencias (dets. 2001). Vastukaja: Arujärv, Evi. Õhumüügist ja turvateenusest // Sirp (2002) 14. juuni, lk. 3. Essee on ilmunud ka kogumikus: Talvet, Jüri. Tõrjumatu äär. Tartu : Ilmamaa, 2005, lk. 9-30

  4. 2003 - Mazda ja Lexuse aasta / Tõnu Tramm

    Index Scriptorium Estoniae

    Tramm, Tõnu, 1968-

    2004-01-01

    Ilmunud ka: Delovõje Vedomosti 14. jaan. lk. 10. Ülevaade uute sõiduautode müügist Eestis 2003. aastal. Tabelid: Uute sõiduautode müük 2003; Mudelite TOP 5 2003; Müük tootjariikide lõikes; Suurimad sõiduautode importöörid; Jaemüüjatele oli 2003. aasta konkurentsitihe

  5. The national nuclear material tracking system. A Korea's countermeasure against nuclear terrorism

    International Nuclear Information System (INIS)

    Moon, Joo Hyun

    2011-01-01

    Since nuclear terrorism has been identified as a real threat, the Korean government has earnestly developed elementary technologies and sub-systems for establishing an integrated defensive system against nuclear terrorism, which is based on the concept of defense-in-depth. This paper introduces the gist and implications of the studies that have been conducted in building the national nuclear material tracking system for preventing and intercepting the illicit trafficking and transporting of nuclear material in Korea. (orig.)

  6. Current research in Radiation Biology and Biochemistry Division

    International Nuclear Information System (INIS)

    Tarachand, U.; Singh, B.B.

    1995-01-01

    The Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay has been engaged in research in the frontier areas of (i) radiation biology related to tumour therapy and injury caused by free radicals; (ii) molecular basis of diseases of physiological origin; (iii) molecular aspects of chemical carcinogenesis and (iv) structure of genome and genome related functions. The gist of research and development activities carried out in the Division during the last two years are documented

  7. Venemaa on meie enda loodud oht / Noam Chomsky ; interv. Dirk Hoyer

    Index Scriptorium Estoniae

    Chomsky, Noam, 1928-

    2008-01-01

    Ühendriikide tuntud arvamusliider sõna- ja ajakirjandusvabadusest USA-s, suhtumisest Iraagi sõtta, avalikkussuhete tööstuse ja parteide juhtkondade toodete müügist presidendivalimiste kampaania käigus, tervishoiusüsteemi katastroofilisest olukorrast USA-s, valikust presidendikandidaatide Barack Obama ja John McCaini vahel, kosmose militariseerimisest, suhtumisest 11. septembrisse, Venemaast Balti julgeoleku ohuna, NATOst julgeoleku garanteerijana, energiaressurssidest kui hirmutamisvahenditest

  8. Primary expatiation on micro material evidence and authentication

    International Nuclear Information System (INIS)

    Yang Mingtai; Wang Wen; Wu Lunqiang; Dai Changsong

    2012-01-01

    The micro material evidence is the impersonal and concrete material evidences, and the quantity and volume is small, but it plays an important role in judicature litigation. In the paper, the basic character, type and form mechanism of the micro material evidence have been analyzed and discussed, and the gist of the micro material evidence has been summarized. It must play a helpful role in the micro material evidence to correlative workers for cognizance and application. (authors)

  9. The national nuclear material tracking system. A Korea's countermeasure against nuclear terrorism

    Energy Technology Data Exchange (ETDEWEB)

    Moon, Joo Hyun [Dongguk Univ., Gyeongbuk (Korea, Republic of)

    2011-07-15

    Since nuclear terrorism has been identified as a real threat, the Korean government has earnestly developed elementary technologies and sub-systems for establishing an integrated defensive system against nuclear terrorism, which is based on the concept of defense-in-depth. This paper introduces the gist and implications of the studies that have been conducted in building the national nuclear material tracking system for preventing and intercepting the illicit trafficking and transporting of nuclear material in Korea. (orig.)

  10. In Vitro–In Vivo Correlation for Gliclazide Immediate-Release Tablets Based on Mechanistic Absorption Simulation

    OpenAIRE

    Grbic, Sandra; Parojcic, Jelena; Ibric, Svetlana; Djuric, Zorica

    2010-01-01

    The aim of this study was to develop a drug-specific absorption model for gliclazide (GLK) using mechanistic gastrointestinal simulation technology (GIST) implemented in GastroPlusTM software package. A range of experimentally determined, in silico predicted or literature data were used as input parameters. Experimentally determined pH-solubility profile was used for all simulations. The human jejunum effective permeability (Peff) value was estimated on the basis of in vitro measured Caco-2 p...

  11. Initial presentation of a giant gastrointestinal stromal tumour of the stomach with recurrent spontaneous intra-peritoneal haemorrhage

    Directory of Open Access Journals (Sweden)

    Margarida Vinagreiro

    2015-01-01

    Discussion and conclusion: GISTs are uncommon and rarely present with spontaneous intra-peritoneal haemorrhage, which may be life threatening. In our understanding, this is the first reported case of the reviewed literature presenting with a chronic hemoperitoneum, due to recurrent brisk episodes of tumour haemorrhage. Tumour rupture and large tumour size are two poor independent prognostic tumour factors for recurrence. Despite this, the patient remains free of disease after surgery and instituted adjuvant imatinib mesylate.

  12. Geometry Dependence of Stellarator Turbulence

    International Nuclear Information System (INIS)

    Mynick, H.E.; Xanthopoulos, P.; Boozer, A.H.

    2009-01-01

    Using the nonlinear gyrokinetic code package GENE/GIST, we study the turbulent transport in a broad family of stellarator designs, to understand the geometry-dependence of the microturbulence. By using a set of flux tubes on a given flux surface, we construct a picture of the 2D structure of the microturbulence over that surface, and relate this to relevant geometric quantities, such as the curvature, local shear, and effective potential in the Schrodinger-like equation governing linear drift modes

  13. Computed tomography in gastrointestinal stromal tumors

    International Nuclear Information System (INIS)

    Ghanem, Nadir; Altehoefer, Carsten; Winterer, Jan; Schaefer, Oliver; Springer, Oliver; Kotter, Elmar; Langer, Mathias; Furtwaengler, Alex

    2003-01-01

    The aim of this study was to define the imaging characteristics of primary and recurrent gastrointestinal stromal tumors (GIST) in computed tomography with respect to the tumor size. Computed tomography was performed in 35 patients with histologically confirmed gastrointestinal stromal tumors and analyzed retrospectively by two experienced and independent radiologist. The following morphologic tumor characteristics of primary (n=20) and (n=16) recurrent tumors were evaluated according to tumor size, shape, homogeneity, density compared with liver, contrast enhancement, presence of calcifications, ulcerations, fistula or distant metastases and the anatomical relationship to the intestinal wall, and the infiltration of adjacent visceral organs. Small GIST ( 5-10 cm) demonstrated an irregular shape, inhomogeneous density on unenhanced and contrast-enhanced images, a combined intra- and extraluminal tumor growth with aggressive findings, and infiltration of adjacent organs in 9 primary diagnosed and 2 recurrent tumors. Large GIST (>10 cm), which were observed in 8 primary tumors and 11 recurrent tumors, showed an irregular margin with inhomogeneous density and aggressive findings, and were characterized by signs of malignancy such as distant and peritoneal metastases. Small recurrent tumors had a similar appearance as compared with large primary tumors. Computed tomography gives additional information with respect to the relationship of gastrointestinal stromal tumor to the gastrointestinal wall and surrounding organs, and it detects distant metastasis. Primary and recurrent GIST demonstrate characteristic CT imaging features which are related to tumor size. Aggressive findings and signs of malignancy are found in larger tumors and in recurrent disease. Computed tomography is useful in detection and characterization of primary and recurrent tumors with regard to tumor growth pattern, tumor size, and varied appearances of gastrointestinal stromal tumors, and indirectly

  14. Impact of a decision aid about stratified ovarian cancer risk-management on women's knowledge and intentions: a randomised online experimental survey study.

    Science.gov (United States)

    Meisel, Susanne F; Freeman, Maddie; Waller, Jo; Fraser, Lindsay; Gessler, Sue; Jacobs, Ian; Kalsi, Jatinderpal; Manchanda, Ranjit; Rahman, Belinda; Side, Lucy; Wardle, Jane; Lanceley, Anne; Sanderson, Saskia C

    2017-11-16

    Risk stratification using genetic and other types of personal information could improve current best available approaches to ovarian cancer risk reduction, improving identification of women at increased risk of ovarian cancer and reducing unnecessary interventions for women at lower risk. Amounts of information given to women may influence key informed decision-related outcomes, e.g. knowledge. The primary aim of this study was to compare informed decision-related outcomes between women given one of two versions (gist vs. extended) of a decision aid about stratified ovarian cancer risk-management. This was an experimental survey study comparing the effects of brief (gist) information with lengthier, more detailed (extended) information on cognitions relevant to informed decision-making about participating in risk-stratified ovarian cancer screening. Women with no personal history of ovarian cancer were recruited through an online survey company and randomised to view the gist (n = 512) or extended (n = 519) version of a website-based decision aid and completed an online survey. Primary outcomes were knowledge and intentions. Secondary outcomes included attitudes (values) and decisional conflict. There were no significant differences between the gist and extended conditions in knowledge about ovarian cancer (time*group interaction: F = 0.20, p = 0.66) or intention to participate in ovarian cancer screening based on genetic risk assessment (t(1029) = 0.43, p = 0.67). There were also no between-groups differences in secondary outcomes. In the sample overall (n = 1031), knowledge about ovarian cancer increased from before to after exposure to the decision aid (from 5.71 to 6.77 out of a possible 10: t = 19.04, p type of content for decision aids about stratified ovarian cancer risk-management. This study was registered with the ISRCTN registry; registration number: ISRCTN48627877 .

  15. Dual Processes in Decision Making and Developmental Neuroscience: A Fuzzy-Trace Model.

    Science.gov (United States)

    Reyna, Valerie F; Brainerd, Charles J

    2011-09-01

    From Piaget to the present, traditional and dual-process theories have predicted improvement in reasoning from childhood to adulthood, and improvement has been observed. However, developmental reversals-that reasoning biases emerge with development -have also been observed in a growing list of paradigms. We explain how fuzzy-trace theory predicts both improvement and developmental reversals in reasoning and decision making. Drawing on research on logical and quantitative reasoning, as well as on risky decision making in the laboratory and in life, we illustrate how the same small set of theoretical principles apply to typical neurodevelopment, encompassing childhood, adolescence, and adulthood, and to neurological conditions such as autism and Alzheimer's disease. For example, framing effects-that risk preferences shift when the same decisions are phrases in terms of gains versus losses-emerge in early adolescence as gist-based intuition develops. In autistic individuals, who rely less on gist-based intuition and more on verbatim-based analysis, framing biases are attenuated (i.e., they outperform typically developing control subjects). In adults, simple manipulations based on fuzzy-trace theory can make framing effects appear and disappear depending on whether gist-based intuition or verbatim-based analysis is induced. These theoretical principles are summarized and integrated in a new mathematical model that specifies how dual modes of reasoning combine to produce predictable variability in performance. In particular, we show how the most popular and extensively studied model of decision making-prospect theory-can be derived from fuzzy-trace theory by combining analytical (verbatim-based) and intuitive (gist-based) processes.

  16. Massive memory revisited: Limitations on storage capacity for object details in visual long-term memory

    OpenAIRE

    Cunningham, Corbin A.; Yassa, Michael A.; Egeth, Howard E.

    2015-01-01

    Previous work suggests that visual long-term memory (VLTM) is highly detailed and has a massive capacity. However, memory performance is subject to the effects of the type of testing procedure used. The current study examines detail memory performance by probing the same memories within the same subjects, but using divergent probing methods. The results reveal that while VLTM representations are typically sufficient to support performance when the procedure probes gist-based information, they...

  17. Gastrointestinal stromal tumours of stomach: Robot-assisted excision with the da Vinci Surgical System regardless of size and location site.

    Science.gov (United States)

    Furbetta, Niccolo; Palmeri, Matteo; Guadagni, Simone; Di Franco, Gregorio; Gianardi, Desirée; Latteri, Saverio; Marciano, Emanuele; Moglia, Andrea; Cuschieri, Alfred; Di Candio, Giulio; Mosca, Franco; Morelli, Luca

    2018-03-23

    The role of minimally invasive surgery of gastrointestinal stromal tumours (GISTs) of the stomach remains uncertain especially for large and/or difficult located tumours. We are hereby presenting a single-centre series of robot-assisted resections using the da Vinci Surgical System (Si or Xi). Data of patients undergoing robot-assisted treatment of gastric GIST were retrieved from the prospectively collected institutional database and a retrospective analysis was performed. Patients were stratified according to size and location of the tumour. Difficult cases (DCs) were considered for size if tumour was> 50 mm and/or for location if the tumour was Type II, III or IV sec. Privette/Al-Thani classification. Between May 2010 and February 2017, 12 consecutive patients underwent robot-assisted treatment of GIST at our institution. DCs were 10/12 cases (83.3%), of which 6/10 (50%) for location, 2/10 (25%) for size and 2/10 (25%) for both. The da Vinci Si was used in 8 patients, of which 6 (75%) were DC, and the da Vinci Xi in 4, all of which (100%) were DC. In all patients, excision was by wedge resection. All lesions had microscopically negative resection margins. There was no conversion to open surgery, no tumour ruptures or spillage and no intraoperative complications. Our experience suggests a positive role of the robot da Vinci in getting gastric GIST removal with a conservative approach, regardless of size and location site. Comparative studies with a greater number of patients are necessary for a more robust assessment.

  18. A Preliminary Empirical Evaluation of Virtual Reality as a Training Tool for Visual-Spatial Tasks

    Science.gov (United States)

    1993-05-01

    Hillsdale, NJ: Lawrence Erlbaum Associates. Craik , F.I.M., & Lockhart , R.S. (1972). Levels of processing ; A framework for memory research. Journal of...short-term memory (Bower, 1972; Kanigel, 1981), elaborative rehearsai in short-term memory, and subsequent retrieval from long-term memory ( Craik ... Lockhart , 1972; Chase & Ericsson, 1981), ?nd the superiority of gist over verbatim recall of sentences (Bransford & Franks, 1971). Even memory for simple

  19. Bibliography of Technical Publications and Papers, October 1979 - September 1980

    Science.gov (United States)

    1980-11-01

    technological procedures affecting quality of radappertized chicken rolls. Institute of Food Technolo- gists, New Orleans, LA, 9-11 June 1980. 93...temperature survey of ginger beef pot roast production at a Central Food Preparation Facility. J. Food Prot., 43(4): 292-294 (1980). 180. REESE, E. T...low-dose irradiated chicken skins. Interagency Botulism Research Coordinating Coummittee, Milford, CT, 8-9 October 1980. 207. CALLO, B. Protoplast

  20. Clinical Outcomes of Patients with Advanced Gastrointestinal Stromal Tumors: Safety and Efficacy in a Worldwide Treatment-use Trial of Sunitinib

    Science.gov (United States)

    Reichardt, Peter; Kang, Yoon-Koo; Rutkowski, Piotr; Schuette, Jochen; Rosen, Lee S; Seddon, Beatrice; Yalcin, Suayib; Gelderblom, Hans; Williams, Charles C; Fumagalli, Elena; Biasco, Guido; Hurwitz, Herbert I; Kaiser, Pamela E; Fly, Kolette; Matczak, Ewa; Chen, Liang; Lechuga, Maria José; Demetri, George D

    2015-01-01

    BACKGROUND To provide sunitinib to patients with gastrointestinal stromal tumor (GIST) who were otherwise unable to obtain sunitinib; to obtain broad safety and efficacy data from a large population of patients with advanced GIST after imatinib failure. METHODS Imatinib-resistant/intolerant patients with advanced GIST received sunitinib on an initial dosing schedule (IDS) of 50 mg/day in 6-week cycles (4 weeks on treatment, 2 weeks off). Tumor assessment frequency was per local practice, with response assessed by investigators per Response Evaluation Criteria in Solid Tumors version 1.0. Overall survival (OS) and safety were assessed regularly. Post-hoc analyses evaluated different patterns of treatment management. RESULTS At final data cutoff, 1124 patients comprised the intent-to-treat population; 15% had a baseline Eastern Cooperative Oncology Group performance status ≥2. Median treatment duration was 7.0 months. Median time to tumor progression was 8.3 months (95% confidence interval [CI], 8.0–9.4), and median OS was 16.6 months (95% CI, 14.9–18.0) with 36% of patients alive at the time of analysis. Patients in whom the IDS was modified exhibited longer median OS (23.5 months) than those treated strictly per the IDS (11.1 months). The most common treatment-related grade 3/4 adverse events (AEs) were hand-foot syndrome (11%), fatigue (9%), neutropenia (8%), hypertension (7%), and thrombocytopenia (6%). Treatment-related AEs associated with cardiac function (eg, congestive heart failure and myocardial infarction) were reported at frequencies of ≤1% each. CONCLUSIONS This treatment-use study confirms the long-term safety and efficacy of sunitinib in a large international population of patients with advanced GIST after imatinib failure. PMID:25641662

  1. High-density transcriptional initiation signals underline genomic islands in bacteria.

    Directory of Open Access Journals (Sweden)

    Qianli Huang

    Full Text Available Genomic islands (GIs, frequently associated with the pathogenicity of bacteria and having a substantial influence on bacterial evolution, are groups of "alien" elements which probably undergo special temporal-spatial regulation in the host genome. Are there particular hallmark transcriptional signals for these "exotic" regions? We here explore the potential transcriptional signals that underline the GIs beyond the conventional views on basic sequence composition, such as codon usage and GC property bias. It showed that there is a significant enrichment of the transcription start positions (TSPs in the GI regions compared to the whole genome of Salmonella enterica and Escherichia coli. There was up to a four-fold increase for the 70% GIs, implying high-density TSPs profile can potentially differentiate the GI regions. Based on this feature, we developed a new sliding window method GIST, Genomic-island Identification by Signals of Transcription, to identify these regions. Subsequently, we compared the known GI-associated features of the GIs detected by GIST and by the existing method Islandviewer to those of the whole genome. Our method demonstrates high sensitivity in detecting GIs harboring genes with biased GI-like function, preferred subcellular localization, skewed GC property, shorter gene length and biased "non-optimal" codon usage. The special transcriptional signals discovered here may contribute to the coordinate expression regulation of foreign genes. Finally, by using GIST, we detected many interesting GIs in the 2011 German E. coli O104:H4 outbreak strain TY-2482, including the microcin H47 system and gene cluster ycgXEFZ-ymgABC that activates the production of biofilm matrix. The aforesaid findings highlight the power of GIST to predict GIs with distinct intrinsic features to the genome. The heterogeneity of cumulative TSPs profiles may not only be a better identity for "alien" regions, but also provide hints to the special

  2. Imatinib induced severe skin reactions and neutropenia in a patient with gastrointestinal stromal tumor

    International Nuclear Information System (INIS)

    Hwang, Jun-Eul; Yoon, Ju-Young; Bae, Woo-Kyun; Shim, Hyun-Jeong; Cho, Sang-Hee; Chung, Ik-Joo

    2010-01-01

    Imatinib mesylate has been used for the treatment of unresectable or metastatic gastrointestinal stromal tumors (GIST). The current recommended dose of imatinib is 400 mg/day that is increased to 800 mg/day in cases with disease progression. However, imatinib can be associated with diverse adverse events, which has limited its use. We report a case of severe adverse skin reactions with neutropenic fever during imatinib treatment in a patient with GIST. A 71-year-old man was admitted with a one month history of epigastric pain and a palpable mass in the right upper quadrant. An abdominal CT scan revealed a 20 × 19 cm intraabdominal mass with tumor invasion into the peritoneum. Needle biopsy was performed and the results showed spindle shaped tumor cells that were positive for c-KIT. The patient was diagnosed with unresectable GIST. Imatinib 400 mg/day was started. The patient tolerated the first eight weeks of treatment. However, about three months later, the patient developed a grade 4 febrile neutropenia and a grade 3 exfoliative skin rash. The patient recovered from this serious adverse events after discontinuation of imatinib with supportive care. However, the skin lesions recurred whenever the patient received imatinib over 100 mg/day. Therefore, imatinib 100 mg/day was maintained. Despite the low dose imatinib, follow up CT showed a marked partial response without grade 3 or 4 toxicities. The recommended dose of imatinib for the treatment of GIST is 400 mg/day but patients at risk for adverse drug reaction may benefit from lower doses. Individualized treatment is needed for such patients, and we may also try sunitinib as a alternative drug

  3. What are quasars. 3. ed.

    International Nuclear Information System (INIS)

    Dautcourt, G.

    1982-01-01

    The subject is covered under the following headings: gigantic explosions in galaxies, the puzzle of far radio sources, all records are broken, the quasar light - a messenger from the far past, the radio mantle of quasars, where do spectral lines originate, mysterious absorption, restless quasars, quasars as infrared sources, what is the gist of the matter, was Einstein wrong, when is a quasar no quasar, quasars and cosmology, youthful escapades of a galaxy, and once again the red shift

  4. Accuracy and feasibility of estimated tumour volumetry in primary gastric gastrointestinal stromal tumours: validation using semiautomated technique in 127 patients.

    Science.gov (United States)

    Tirumani, Sree Harsha; Shinagare, Atul B; O'Neill, Ailbhe C; Nishino, Mizuki; Rosenthal, Michael H; Ramaiya, Nikhil H

    2016-01-01

    To validate estimated tumour volumetry in primary gastric gastrointestinal stromal tumours (GISTs) using semiautomated volumetry. In this IRB-approved retrospective study, we measured the three longest diameters in x, y, z axes on CTs of primary gastric GISTs in 127 consecutive patients (52 women, 75 men, mean age 61 years) at our institute between 2000 and 2013. Segmented volumes (Vsegmented) were obtained using commercial software by two radiologists. Estimate volumes (V1-V6) were obtained using formulae for spheres and ellipsoids. Intra- and interobserver agreement of Vsegmented and agreement of V1-6 with Vsegmented were analysed with concordance correlation coefficients (CCC) and Bland-Altman plots. Median Vsegmented and V1-V6 were 75.9, 124.9, 111.6, 94.0, 94.4, 61.7 and 80.3 cm(3), respectively. There was strong intra- and interobserver agreement for Vsegmented. Agreement with Vsegmented was highest for V6 (scalene ellipsoid, x ≠ y ≠ z), with CCC of 0.96 [95 % CI 0.95-0.97]. Mean relative difference was smallest for V6 (0.6 %), while it was -19.1 % for V5, +14.5 % for V4, +17.9 % for V3, +32.6 % for V2 and +47 % for V1. Ellipsoidal approximations of volume using three measured axes may be used to closely estimate Vsegmented when semiautomated techniques are unavailable. Estimation of tumour volume in primary GIST using mathematical formulae is feasible. Gastric GISTs are rarely spherical. Segmented volumes are highly concordant with three axis-based scalene ellipsoid volumes. Ellipsoid volume can be used as an alternative for automated tumour volumetry.

  5. Cloud computing: Overview of available solutions

    OpenAIRE

    Feňko, Marek

    2012-01-01

    The paper Works describes concept of cloud computing, his main characteristics. Cloud computing is new trend in IT. The company doesn't have your own servers and data centres, but everything is situated in cloud -- in set of pc and server. The owners of these are suppliers of these services. The aim of the thesis is defined Cloud Computing concepts and evaluate by criterion if cloud computing application can compete to classic application. Introduction of the Works describe the gist of cloud ...

  6. Swedbank ei kavatse Hansapanka müüa

    Index Scriptorium Estoniae

    2008-01-01

    Maailma ühe suurima panga Citigroup analüütikute raporti järgi oleks Swedbanki panga väärtus palju suurem, kui panga mõned osad maha müüa. Hansapanga juhatuse esimehe Erkki Raasukese sõnul pole Swedbanki juhid rääkinud Hansapanga müügist, mis tähendaks panga strateegia muutmist

  7. Sügisõhtu : [luuletused] / Kersti Merilaas

    Index Scriptorium Estoniae

    Merilaas, Kersti, pseud., 1913-1986

    1998-01-01

    Sisu: Sügisõhtu ; Hulguse laul ; Öö ; Mina magan ; Suletud luugid ; Viimne paat ; Usalda oma silmi ; Punane moon ; Rannapääsuke ; Mägiste Märt ; Võõrdumus ; "Minna midagi nõudmata..." ; Lihtne lauluke ; Kohtupäev ; Diogenes ; Kui põletasin need kirjad ; Laul ; Need vanad astjad ; Hobune ; Käolina ; Usutunnistus ; Nägemus

  8. Aspects of surgical treatment for gastro-intestinal stromal tumors; Chirurgische Therapieaspekte gastrointestinaler Stromatumoren

    Energy Technology Data Exchange (ETDEWEB)

    Hohenberger, P. [Medizinische Fakultaet Mannheim, Universitaet Heidelberg, Sektion Chirurgische Onkologie und Thoraxchirurgie, Chirurgische Universitaetsklinik, Mannheim (Germany)

    2009-12-15

    Gastro-intestinal stromal tumors (GIST) form the commonest subgroup of soft tissue sarcomas. They arise in the muscular layer of the esophagus, stomach, small intestines and rectum. Characteristic and important for the assessment of the extent of tumors is the peripheral rim vascularization of primary tumors and metastases. Indications for resection are given for tumors larger than 2 cm in size. Locally advanced GISTs can be advantageously treated with imatinib/sunitinib as neoadjuvant and it is often possible to select a low level of resection for this size of tumor and when the rim area is not hypervascularized. Even in the metastizing stage surgical treatment can be used for elimination of resistant metastases or for removal of residual tumor tissue in an attempt to counteract secondary tumor progression. The effect of this treatment is currently being tested in a randomized phase III study. (orig.) [German] Gastrointestinale Stromatumoren (GIST) stellen die haeufigste Subgruppe von Weichgewebesarkomen dar. Sie entstehen in der Muskularisschicht von Oesophagus, Magen, Duenndarm und Rektum. Charakteristisch und wichtig fuer die Einschaetzung des Tumorausmasses ist die Randvaskularisation von Primaertumoren und Metastasen. Die Indikation zur Resektion gilt fuer Tumoren ab 2 cm Groesse. Lokal fortgeschrittene GIST koennen sehr vorteilhaft mit Imatinib/Sunitinib neoadjuvant vorbehandelt werden, und es ist oft moeglich, bei der Tumorgroesse und wenn keine hypervaskularisierten Randbereiche vorliegen, ein geringeres Resektionsausmass zu waehlen. Auch im metastasierten Stadium hat die chirurgische Therapie einen Platz zur Eliminierung resistenter Metastasen bzw. zur Entfernung von Residualtumorgewebe als Versuch, einer sekundaeren Tumorprogression zu begegnen. Dieser Behandlungseffekt wird derzeit in einer randomisierten Phase-III-Studie ueberprueft. (orig.)

  9. Dual Processes in Decision Making and Developmental Neuroscience: A Fuzzy-Trace Model

    Science.gov (United States)

    Reyna, Valerie F.; Brainerd, Charles J.

    2011-01-01

    From Piaget to the present, traditional and dual-process theories have predicted improvement in reasoning from childhood to adulthood, and improvement has been observed. However, developmental reversals—that reasoning biases emerge with development —have also been observed in a growing list of paradigms. We explain how fuzzy-trace theory predicts both improvement and developmental reversals in reasoning and decision making. Drawing on research on logical and quantitative reasoning, as well as on risky decision making in the laboratory and in life, we illustrate how the same small set of theoretical principles apply to typical neurodevelopment, encompassing childhood, adolescence, and adulthood, and to neurological conditions such as autism and Alzheimer's disease. For example, framing effects—that risk preferences shift when the same decisions are phrases in terms of gains versus losses—emerge in early adolescence as gist-based intuition develops. In autistic individuals, who rely less on gist-based intuition and more on verbatim-based analysis, framing biases are attenuated (i.e., they outperform typically developing control subjects). In adults, simple manipulations based on fuzzy-trace theory can make framing effects appear and disappear depending on whether gist-based intuition or verbatim-based analysis is induced. These theoretical principles are summarized and integrated in a new mathematical model that specifies how dual modes of reasoning combine to produce predictable variability in performance. In particular, we show how the most popular and extensively studied model of decision making—prospect theory—can be derived from fuzzy-trace theory by combining analytical (verbatim-based) and intuitive (gist-based) processes. PMID:22096268

  10. Small bowel Gastrointestinal Stromal Tumors can physiologically alter gut motility before causing mechanical obstruction

    OpenAIRE

    Kothari, Manish S; Kosmoliaptsis, Vasilis; Meyrick-Thomas, John

    2005-01-01

    Background Gastro Intestinal Stromal Tumors (GISTs) are rare stromal neoplasms that represent the most common mesenchymal tumor of the G.I. tract, accounting for 5% of all sarcomas [1,2]. Originating from interstitial cells of Cajal, which are regulators of gut peristalsis, they are preferentially located in the stomach and the small intestine [3] and clinical presentation is variable, ranging from vague complaints to major G.I. bleeding. Surgical resection is the mainstay of treatment for pa...

  11. Social Entrepreneurship Practice in Malaysia - The Case of Social NGO

    OpenAIRE

    Fakhrul Anwar Zainol; Wan Norhayate Wan Daud; Zulhamri Abdullah; Mohd Rafi Yaacob

    2014-01-01

    This study scrutinises innovation, proactiveness and risk taking as indicators of effectiveness of a social NGO within the context of urban poverty, using Global Outreach as a case. This study begins with the introduction of brief background of organisation. Later,innovation, proactiveness and risk taking which are the gists of the content of the paper are discussed at length. As far as this case study is concerned, Global Outreach is effective enough. Capitasing on amended model of Grameen’s...

  12. Gastrointestinal stromal tümörler (GİST) - Patoloji ve yeni moleküler gelişimlerin klinik uygulamaları - Bir perspektif yorum

    OpenAIRE

    Dudani, Sharmila; Kalhan, Shivani; Sharma, Sonia; Gupta, Anshu

    2014-01-01

     Gastrointestinal stromal tumours ( GISTs) are the most common  mesenchymal tumours of the GI tract. They occur most frequently in stomach (60-70%), or small intestine(SI) ( 25-30%). Rare sites include colon, rectum, appendix and esophagus (<10%). On histology their appearance varies from cellular spindle cell tumours to epithelioid to pleomorphic tumours. Traditionally, three criteria have been used to determine malignancy, which include site of origin (SI and rectal tumours  are more...

  13. Current research in Radiation Biology and Biochemistry Division

    Energy Technology Data Exchange (ETDEWEB)

    Tarachand, U; Singh, B B [eds.; Bhabha Atomic Research Centre, Bombay (India). Radiation Biology and Biochemistry Div.

    1996-12-31

    The Radiation Biology and Biochemistry Division, Bhabha Atomic Research Centre, Bombay has been engaged in research in the frontier areas of (i) radiation biology related to tumour therapy and injury caused by free radicals; (ii) molecular basis of diseases of physiological origin; (iii) molecular aspects of chemical carcinogenesis and (iv) structure of genome and genome related functions. The gist of research and development activities carried out in the Division during the last two years are documented.

  14. Gastric Duplication Cyst: A Rare Congenital Disease Often Misdiagnosed in Adults

    Directory of Open Access Journals (Sweden)

    Jessica Falleti

    2013-01-01

    Full Text Available Gastrointestinal duplication is a rare congenital disease which affected more commonly the ileum, while the stomach is rarely involved. Generally diagnosed in paediatric or young age, it could be difficult to suspect a gastrointestinal duplication in adults. Herein, we report a 55-year-old male with a gastric duplication cyst found on routinely checkup for chronic hepatitis and first misdiagnosed as a gastrointestinal stromal tumor (GIST; we also discuss its embryology.

  15. A rare case with synchronous gastric gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and uterine leiomyoma.

    Science.gov (United States)

    Arabadzhieva, Elena; Yonkov, Atanas; Bonev, Sasho; Bulanov, Dimitar; Taneva, Ivanka; Vlahova, Alexandrina; Dikov, Tihomir; Dimitrova, Violeta

    2016-11-15

    Although gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, they comprise less than 1% of all gastrointestinal tumors. Neuroendocrine tumors (NET) of the gastro-enteropancreatic system are also rare, representing about 2% of all gastrointestinal neoplasms. Pancreatic localization of NET is extremely uncommon-these tumors are only 1-5% of all pancreatic cancers. We describe an unusual case with triple tumor localization-a gastric tumor, a formation in the pancreas, which involves the retroperitoneal space, and a uterine leiomyoma. The exact diagnosis was confirmed with immunohistochemical study after surgical treatment of the patient. Distal pancreatic resection, splenectomy, partial gastrectomy, omentectomy, and hysterectomy were performed. The histological examination proved an epithelioid type of gastric GIST. Immunostaining showed focal positive expression of c-kit and no mitotic figures per 50 HPF. Histology of the pancreatic and retroperitoneal formation proved a well-differentiated NET with origin from the islets of Langerhans. The immunohistochemical study demonstrated co-expression of chromogranin A and synaptophysin. This is the fourth case published so far of a patient with synchronous pancreatic NET and gastric GIST. The main objective of the study is to present a unique case because we have not found any reports for coexistence of the described three types of neoplasm, as in our patient, and we hope that it will be valuable in the future investigations about the genesis, diagnosis, and treatment of these types of tumors.

  16. When Irrational Biases Are Smart: A Fuzzy-Trace Theory of Complex Decision Making

    Directory of Open Access Journals (Sweden)

    Valerie Reyna

    2018-06-01

    Full Text Available I take a decision-making approach to consider ways of addressing the “unresolved and dramatic problems in the world”. Traditional approaches to good decision-making are reviewed. These approaches reduce complex decisions to tradeoffs between magnitudes of probabilities, and outcomes in which the quantity and precision of information are key to making good decisions. I discuss a contrasting framework, called “fuzzy-trace theory”, which emphasizes understanding the simple gist of options and applying core social and moral values. Importantly, the tendency to rely on meaningful but simple gist increases from childhood to adulthood (or, in adulthood, as people gain experience in a domain, so that specific irrational biases grow with knowledge and experience. As predicted theoretically, these violations of rationality in the traditional sense are associated empirically with healthier and more adaptive outcomes. Thus, interventions that help decision makers understand the essential gist of their options and how it connects to core values are practical approaches to reducing “unresolved and dramatic problems in the world” one decision at a time.

  17. Optimizing Treatment Outcomes With Regorafenib: Personalized Dosing and Other Strategies to Support Patient Care

    Science.gov (United States)

    van Cutsem, Eric; Blay, Jean-Yves; Sobrero, Alberto; Demetri, George D.

    2014-01-01

    Regorafenib is an oral multikinase inhibitor that inhibits several kinases relevant to tumor biology in several cancers, including colorectal carcinoma (CRC) and gastrointestinal stromal tumor (GIST). In phase III trials, regorafenib significantly improved overall survival versus placebo in patients with metastatic CRC progressing after all available standard therapies, and significantly prolonged progression-free survival in patients with advanced GIST in whom at least imatinib and sunitinib had failed. Thus, this agent holds promise as a new standard of care for CRC and GIST patients after disease progression following all other approved therapies. The clinical trials reported to date show that this new treatment has a consistent adverse event profile that is quite different from that of traditional cytotoxic chemotherapies. The most common adverse events of regorafenib include dermatologic and mucosal toxicities (especially hand-foot skin reaction, rash, and oral mucositis), constitutional symptoms (e.g., fatigue, nausea, and weight loss), vascular effects (especially hypertension), and gastrointestinal symptoms (e.g., diarrhea). To help health care professionals anticipate and manage the adverse events associated with regorafenib, we describe our experiences in clinical trials and show that such toxicities can be effectively managed with close observation of patients from initiation of dosing, along with prompt appropriate interventions, including dose modifications, if necessary. PMID:24821824

  18. Current Molecular Targeted Therapies for Bone and Soft Tissue Sarcomas

    Directory of Open Access Journals (Sweden)

    Kenji Nakano

    2018-03-01

    Full Text Available Systemic treatment options for bone and soft tissue sarcomas remained unchanged until the 2000s. These cancers presented challenges in new drug development partly because of their rarity and heterogeneity. Many new molecular targeting drugs have been tried in the 2010s, and some were approved for bone and soft tissue sarcoma. As one of the first molecular targeted drugs approved for solid malignant tumors, imatinib’s approval as a treatment for gastrointestinal stromal tumors (GISTs has been a great achievement. Following imatinib, other tyrosine kinase inhibitors (TKIs have been approved for GISTs such as sunitinib and regorafenib, and pazopanib was approved for non-GIST soft tissue sarcomas. Olaratumab, the monoclonal antibody that targets platelet-derived growth factor receptor (PDGFR-α, was shown to extend the overall survival of soft tissue sarcoma patients and was approved in 2016 in the U.S. as a breakthrough therapy. For bone tumors, new drugs are limited to denosumab, a receptor activator of nuclear factor κB ligand (RANKL inhibitor, for treating giant cell tumors of bone. In this review, we explain and summarize the current molecular targeting therapies approved and in development for bone and soft tissue sarcomas.

  19. Gastrointestinal stromal tumors as an incidental finding in patients with a presumptive diagnosis of ovarian cancer.

    Science.gov (United States)

    Muñoz, Mario; Ramirez, Pedro T; Echeverri, Carolina; Alvarez, Luis Guillermo; Palomino, Maria Alejandra; Pareja, Luis René

    2012-01-01

    To report the clinical presentation and oncologic outcomes of a series of patients who presented with an abdominal or pelvic mass and were diagnosed with a gastrointestinal stromal tumor (GIST). Data were obtained on all patients who presented with an abdominal or pelvic mass between September 2007 and June 2010 and who were ultimately diagnosed with a GIST. The patients' medical records were reviewed. A literature review was also conducted. Six patients were identified who met the inclusion criteria. All six patients had a tumor in the intestinal tract arising from the small bowel. The mean tumor size was 12 cm (range, 6 to 22 cm). A complete resection was achieved in five of the six patients. There were no intraoperative complications; one patient had a postoperative complication. Two patients were treated with imatinib after surgery. The mean follow-up time was 32 months (range, 0.3 to 40 months). At the last follow-up, five of the six patients were without any evidence of disease. One patient died of an unrelated hepatic encephalopathy. The incidence in our institution is 3%. GISTs are uncommon; however, they should be considered in the differential diagnosis of patients presenting with an abdominal or pelvic mass.

  20. A new intuitionism: Meaning, memory, and development in Fuzzy-Trace Theory

    Science.gov (United States)

    Reyna, Valerie F.

    2014-01-01

    Combining meaning, memory, and development, the perennially popular topic of intuition can be approached in a new way. Fuzzy-trace theory integrates these topics by distinguishing between meaning-based gist representations, which support fuzzy (yet advanced) intuition, and superficial verbatim representations of information, which support precise analysis. Here, I review the counterintuitive findings that led to the development of the theory and its most recent extensions to the neuroscience of risky decision making. These findings include memory interference (worse verbatim memory is associated with better reasoning); nonnumerical framing (framing effects increase when numbers are deleted from decision problems); developmental decreases in gray matter and increases in brain connectivity; developmental reversals in memory, judgment, and decision making (heuristics and biases based on gist increase from childhood to adulthood, challenging conceptions of rationality); and selective attention effects that provide critical tests comparing fuzzy-trace theory, expected utility theory, and its variants (e.g., prospect theory). Surprising implications for judgment and decision making in real life are also discussed, notably, that adaptive decision making relies mainly on gist-based intuition in law, medicine, and public health. PMID:25530822

  1. A new intuitionism: Meaning, memory, and development in Fuzzy-Trace Theory.

    Science.gov (United States)

    Reyna, Valerie F

    2012-05-01

    Combining meaning, memory, and development, the perennially popular topic of intuition can be approached in a new way. Fuzzy-trace theory integrates these topics by distinguishing between meaning-based gist representations, which support fuzzy (yet advanced) intuition, and superficial verbatim representations of information, which support precise analysis. Here, I review the counterintuitive findings that led to the development of the theory and its most recent extensions to the neuroscience of risky decision making. These findings include memory interference (worse verbatim memory is associated with better reasoning); nonnumerical framing (framing effects increase when numbers are deleted from decision problems); developmental decreases in gray matter and increases in brain connectivity; developmental reversals in memory, judgment, and decision making (heuristics and biases based on gist increase from childhood to adulthood, challenging conceptions of rationality); and selective attention effects that provide critical tests comparing fuzzy-trace theory, expected utility theory, and its variants (e.g., prospect theory). Surprising implications for judgment and decision making in real life are also discussed, notably, that adaptive decision making relies mainly on gist-based intuition in law, medicine, and public health.

  2. A new intuitionism: Meaning, memory, and development in Fuzzy-Trace Theory

    Directory of Open Access Journals (Sweden)

    Valerie F. Reyna

    2012-05-01

    Full Text Available Combining meaning, memory, and development, the perennially popular topic of intuition can be approached in a new way. Fuzzy-trace theory integrates these topics by distinguishing between meaning-based gist representations, which support fuzzy (yet advanced intuition, and superficial verbatim representations of information, which support precise analysis. Here, I review the counterintuitive findings that led to the development of the theory and its most recent extensions to the neuroscience of risky decision making. These findings include memory interference (worse verbatim memory is associated with better reasoning; nonnumerical framing (framing effects increase when numbers are deleted from decision problems; developmental decreases in gray matter and increases in brain connectivity; developmental reversals in memory, judgment, and decision making (heuristics and biases based on gist increase from childhood to adulthood, challenging conceptions of rationality; and selective attention effects that provide critical tests comparing fuzzy-trace theory, expected utility theory, and its variants (e.g., prospect theory. Surprising implications for judgment and decision making in real life are also discussed, notably, that adaptive decision making relies mainly on gist-based intuition in law, medicine, and public health.

  3. Decreased susceptibility to false memories from misinformation in hormonal contraception users.

    Science.gov (United States)

    Petersen, Nicole; Patihis, Lawrence; Nielsen, Shawn E

    2015-01-01

    Sex hormones are increasingly implicated in memory formation. Recent literature has documented a relationship between hormones and emotional memory and sex differences, which are likely related to hormones, have long been demonstrated in a variety of mnemonic domains, including false memories. Hormonal contraception (HC), which alters sex hormones, has been associated with a bias towards gist memory and away from detailed memory in women who use it during an emotional memory task. Here, we investigated whether HC was associated with changes in susceptibility to false memories, which may be related to the formation of gist memories. We tested false memory susceptibility using two well-validated false memory paradigms: the Deese-Roediger-McDermott (DRM) task, and a story-based misinformation task. We found that hormonal contraceptive users were less susceptible to false memories compared to non-users in the misinformation task, and no differences were seen between groups on the DRM task. We hypothesise that the differences in false memories from the misinformation task may be related to hormonal contraceptive users' memory bias away from details, towards gist memory.

  4. The predictive value of preoperative {sup 18}F-fluorodeoxyglucose PET for postoperative recurrence in patients with localized primary gastrointestinal stromal tumour

    Energy Technology Data Exchange (ETDEWEB)

    Miyake, Kanae Kawai; Nakamoto, Yuji; Togashi, Kaori [Kyoto University Hospital, Department of Diagnostic Imaging and Nuclear Medicine, Kyoto (Japan); Mikami, Yoshiki [Kyoto University Hospital, Department of Diagnostic Pathology, Kyoto (Japan); Kumamoto University Hospital, Department of Diagnostic Pathology, Kumamoto (Japan); Tanaka, Shiro [Kyoto University, Department of Pharmacoepidemiology, Graduate School of Medicine and Public Health, Kyoto (Japan); Higashi, Tatsuya [Shiga Medical Center Research Institute, Shiga (Japan); Tadamura, Eiji [Sakazaki Clinic, Department of Radiology, Kyoto (Japan); Saga, Tsuneo [National Institute of Radiological Sciences, Dianostic Imaging Group, Molecular Imaging Center, Chiba (Japan); Minami, Shunsuke [Shiga Medical Center for Adults, Department of Radiology, Shiga (Japan)

    2016-12-15

    To assess the potential value of preoperative {sup 18}F-FDG PET to predict postoperative recurrence of solitary localized primary gastrointestinal stromal tumour (GIST) after radical resection. A total of 46 patients with primary GIST who received preoperative {sup 18}F-FDG PET and underwent complete resection without neoadjuvant therapy were retrospectively studied. PET findings, including ring-shaped uptake and intense uptake, were compared with Joensuu risk grades using Fisher's exact test. The prognostic value of the preoperative clinico-imaging variables - age ≥60 years, male, ring-shaped uptake, intense uptake, tumour size >5 cm, heterogeneous CT attenuation and lower gastrointestinal origin - and Joensuu high risk for recurrence-free survival was evaluated using log-rank test and multivariate Cox regression analysis. Ring-shaped uptake and intense uptake were significantly associated with Joensuu high risk. Univariate analysis showed that ring-shaped uptake, intense uptake, size >5 cm and Joensuu high risk were significantly associated with inferior recurrence-free survival. Multivariate analysis showed that ring-shaped uptake (P = 0.004) and Joensuu high risk (P = 0.021) were independent adverse prognostic factors of postoperative recurrence. Ring-shaped uptake on preoperative {sup 18}F-FDG PET may be a potential predictor of postoperative tumour recurrence of localized primary GISTs. (orig.)

  5. Gastrointestinal Stromal Tumors with Unusual Localization: Report of Three Cases with a Brief Literature Review.

    Science.gov (United States)

    Yucel, Ahmet Fikret; Sunar, Haldun; Hut, Adnan; Kocakusak, Ahmet; Pergel, Ahmet; Barut, Gul; Dikici, Suleyman

    2010-07-26

    The most common tumors derived from the mesenchyme of the gastrointestinal system are stromal tumors. These tumors are typically seen in the stomach and small intestine and less frequently in the colon, rectum and esophagus and are very rarely located outside the gastrointestinal system. Cure is provided with complete surgical resection with resection borders free of tumor. Tumor size, mitotic index, localization, CD117 and CD34 negativity in immunohistochemical studies, mucosal ulceration and presence of necrosis help to predict recurrence of the illness and patient survival. In high-risk gastrointestinal stromal tumors (GISTs) there is an increased rate of recurrence and shortened survival despite complete surgical resection. Thus patients with a high-risk GIST should be given adjuvant therapy with imatinib mesylate. Sunitinib maleate is another FDA-approved agent only for cases who cannot tolerate imatinib or who are resistant to it. Herein we present three cases with GISTs in different locations of the gastrointestinal system with a review of the relevant literature.

  6. Gastrointestinal Stromal Tumors with Unusual Localization: Report of Three Cases with a Brief Literature Review

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    Ahmet Fikret Yucel

    2010-07-01

    Full Text Available The most common tumors derived from the mesenchyme of the gastrointestinal system are stromal tumors. These tumors are typically seen in the stomach and small intestine and less frequently in the colon, rectum and esophagus and are very rarely located outside the gastrointestinal system. Cure is provided with complete surgical resection with resection borders free of tumor. Tumor size, mitotic index, localization, CD117 and CD34 negativity in immunohistochemical studies, mucosal ulceration and presence of necrosis help to predict recurrence of the illness and patient survival. In high-risk gastrointestinal stromal tumors (GISTs there is an increased rate of recurrence and shortened survival despite complete surgical resection. Thus patients with a high-risk GIST should be given adjuvant therapy with imatinib mesylate. Sunitinib maleate is another FDA-approved agent only for cases who cannot tolerate imatinib or who are resistant to it. Herein we present three cases with GISTs in different locations of the gastrointestinal system with a review of the relevant literature.

  7. Gastrointestinal Stromal Tumor of the Stomach with Narrow Stalk-Like Based, Uneven Protruding Appearance Presenting with Severe Acute Anemia despite Small Size

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    Tomomitsu Tahara

    2010-03-01

    Full Text Available We report the case of a 56-year-old woman who had a gastrointestinal stromal tumor (GIST of the stomach. She was admitted to our hospital for epigastric pain, nausea, and severe acute anemia (hemoglobin level 4.3 g/dl. Esophagogastroduodenoscopy revealed a narrow stalk-like based, hemorrhagic and uneven protruding lesion in the lesser curvature of the gastric upper corpus. Although the tumor was less than 2 cm in diameter and was probably a benign GIST according to histology, laparoscopy-assisted local resection was needed because the patient had continuous severe anemia and epigastric pain. Histological assessment showed that the elongated spindle-like tumor cells originated from the intrinsic muscle layer, and was shown with growth to the mucosal side, cropping out to the surface in most areas of the protruding lesion. Only a small part of the tumor was within nontumoral gastric mucosa. Most of the tumor cells demonstrated immunoreactivity for KIT and CD34 in the cytoplasm but not for αSMA, S100, and desmin. Mitotic activity (0/50 high power field and the labeling index for MIB-1 (about 1% were low. The GIST of the stomach described in this report was a rare case with a narrow stalk-like based, uneven protruding mass presenting with severe acute anemia despite small size.

  8. Correlation of Dynamic PET and Gene Array Data in Patients with Gastrointestinal Stromal Tumors

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    Ludwig G. Strauss

    2012-01-01

    Full Text Available Introduction. The results obtained with dynamic PET (dPET were compared to gene expression data obtained in patients with gastrointestinal stromal tumors (GIST. The primary aim was to assess the association of the dPET results and gene expression data. Material and Methods. dPET was performed following the injection of F-18-fluorodeoxyglucose (FDG in 22 patients with GIST. All patients were examined prior to surgery for staging purpose. Compartment and noncompartment models were used for the quantitative evaluation of the dPET examinations. Gene array data were based on tumor specimen obtained by surgery after the PET examinations. Results. The data analysis revealed significant correlations for the dPET parameters and the expression of zinc finger genes (znf43, znf85, znf91, znf189. Furthermore, the transport of FDG (k1 was associated with VEGF-A. The cell cycle gene cyclin-dependent kinase inhibitor 1C was correlated with the maximum tracer uptake (SUVmax in the tumors. Conclusions. The data demonstrate a dependency of the tracer kinetics on genes associated with prognosis in GIST. Furthermore, angiogenesis and cell proliferation have an impact on the tracer uptake.

  9. Effects of mitomycin C on infiltration of polymorphonuclear leukocytes after epithelial scrape injury in the mouse cornea Efeito da mitomicina C na infiltração de leucócitos polimorfonucleares após lesão epitelial em córnea de camundongo

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    Ana Cecília Souza Leão Escarião

    2008-12-01

    Full Text Available PURPOSE: To determine whether mitomycin C (MMC alters appearance and disappearance of polymorphonuclear leucocytes (PMN in the cornea stroma, using an epithelial scrape injury in eye mouse model. METHODS: Twenty-mice underwent mechanical epithelium debridement in the central cornea using 20% ethanol. After the scrape, the right eye received 0.02% MMC for one minute, while the left eye received physiological saline. The animals were sacrificed on days 1, 2, 5, and 14 after surgery, and corneal whole mounts were prepared for histology. PMN distribution was analyzed in digitized microscope images. Cell division in the cornea was determined by immunohistochemical detection of bromodeoxyuridine (BrdU, which was injected intraperitoneally before the mice were sacrificed. RESULTS: Epithelial scrape injury triggered infiltration of PMNs into the corneal stroma. An analysis of PMN distribution revealed that there was no difference between eyes treated with and without MMC at all time points. BrdU labeling showed that 0.02% MMC for one minute blocked keratocyte proliferation completely. CONCLUSION: MMC treatment regimen, which is common in clinical practice, inhibits keratocyte proliferation during wound healing, but when used at 0.02% for one minute, it does not affect PMN infiltration into the corneal stroma, and subsequent movement toward the injury site, or the disappearance of PMNs from the stroma, in the mouse epithelial injury model.OBJETIVO: O objetivo do estudo foi determinar se a mitomicina C (MMC altera o aparecimento dos leucócitos polimorfonucleares (PMN no estroma corneano após abrasão epitelial central, utilizando olhos de camundongo como modelo. MÉTODOS: Vinte camundongos foram submetidos à abrasão epitelial em córnea central utilizando etanol a 20%. Após a lesão, o olho direito recebeu MMC a 0,02% por 1 minuto, enquanto o olho esquerdo recebeu solução salina. Os animais foram sacrificados em 1, 2, 5 e 14 dias após a cirurgia e

  10. Association of KIT exon 9 mutations with nongastric primary site and aggressive behavior: KIT mutation analysis and clinical correlates of 120 gastrointestinal stromal tumors.

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    Antonescu, Cristina R; Sommer, Gunhild; Sarran, Lisa; Tschernyavsky, Sylvia J; Riedel, Elyn; Woodruff, James M; Robson, Mark; Maki, Robert; Brennan, Murray F; Ladanyi, Marc; DeMatteo, Ronald P; Besmer, Peter

    2003-08-15

    Activating mutations of the KIT juxtamembrane region are the most common genetic events in gastrointestinal stromal tumors (GISTs) and have been noted as independent prognostic factors. The impact of KIT mutation in other regions, such as the extracellular or kinase domains, is not well-defined and fewer than 30 cases have been published to date. One hundred twenty GISTs, confirmed by KIT immunoreactivity, were evaluated for the presence of KIT exon 9, 11, 13, and 17 mutations. The relation between the presence/type of KIT mutation and clinicopathological factors was analyzed using Fisher's exact test and log-rank test. Forty-four % of the tumors were located in the stomach, 47% in the small bowel, 6% in the rectum, and 3% in the retroperitoneum. Overall, KIT mutations were detected in 78% of patients as follows: 67% in exon 11, 11% in exon 9, and none in exon 13 or 17. The types of KIT exon 11 mutations were heterogeneous and clustered in the classic "hot spot" at the 5' end of exon 11. Seven % of cases showed internal tandem duplications (ITD) at the 3' end of exon 11, in a region that we designate as a second hot spot for KIT mutations. Interestingly, these cases were associated with: female predominance, stomach location, occurrence in older patients, and favorable outcome. There were significant associations between exon 9 mutations and large tumor size (P < 0.001) and extragastric location (P = 0.02). Ten of these 13 patients with more than 1-year follow-up have developed recurrent disease. Most KIT-expressing GISTs show KIT mutations that are preferentially located within the classic hot spot of exon 11. In addition, we found an association between a second hot spot at the 3'end of exon 11, characterized by ITDs, and a subgroup of clinically indolent gastric GISTs in older females. KIT exon 9 mutations seem to define a distinct subset of GISTs, located predominantly in the small bowel and associated with an unfavorable clinical course.

  11. Impact of a decision aid about stratified ovarian cancer risk-management on women’s knowledge and intentions: a randomised online experimental survey study

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    Susanne F. Meisel

    2017-11-01

    Full Text Available Abstract Background Risk stratification using genetic and other types of personal information could improve current best available approaches to ovarian cancer risk reduction, improving identification of women at increased risk of ovarian cancer and reducing unnecessary interventions for women at lower risk. Amounts of information given to women may influence key informed decision-related outcomes, e.g. knowledge. The primary aim of this study was to compare informed decision-related outcomes between women given one of two versions (gist vs. extended of a decision aid about stratified ovarian cancer risk-management. Methods This was an experimental survey study comparing the effects of brief (gist information with lengthier, more detailed (extended information on cognitions relevant to informed decision-making about participating in risk-stratified ovarian cancer screening. Women with no personal history of ovarian cancer were recruited through an online survey company and randomised to view the gist (n = 512 or extended (n = 519 version of a website-based decision aid and completed an online survey. Primary outcomes were knowledge and intentions. Secondary outcomes included attitudes (values and decisional conflict. Results There were no significant differences between the gist and extended conditions in knowledge about ovarian cancer (time*group interaction: F = 0.20, p = 0.66 or intention to participate in ovarian cancer screening based on genetic risk assessment (t(1029 = 0.43, p = 0.67. There were also no between-groups differences in secondary outcomes. In the sample overall (n = 1031, knowledge about ovarian cancer increased from before to after exposure to the decision aid (from 5.71 to 6.77 out of a possible 10: t = 19.04, p < 0.001, and 74% of participants said that they would participate in ovarian cancer screening based on genetic risk assessment. Conclusions No differences in knowledge or

  12. Gastrointestinal stromal tumors, somatic mutations and candidate genetic risk variants.

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    Katie M O'Brien

    Full Text Available Gastrointestinal stromal tumors (GISTs are rare but treatable soft tissue sarcomas. Nearly all GISTs have somatic mutations in either the KIT or PDGFRA gene, but there are no known inherited genetic risk factors. We assessed the relationship between KIT/PDGFRA mutations and select deletions or single nucleotide polymorphisms (SNPs in 279 participants from a clinical trial of adjuvant imatinib mesylate. Given previous evidence that certain susceptibility loci and carcinogens are associated with characteristic mutations, or "signatures" in other cancers, we hypothesized that the characteristic somatic mutations in the KIT and PDGFRA genes in GIST tumors may similarly be mutational signatures that are causally linked to specific mutagens or susceptibility loci. As previous epidemiologic studies suggest environmental risk factors such as dioxin and radiation exposure may be linked to sarcomas, we chose 208 variants in 39 candidate genes related to DNA repair and dioxin metabolism or response. We calculated adjusted odds ratios (ORs and 95% confidence intervals (CIs for the association between each variant and 7 categories of tumor mutation using logistic regression. We also evaluated gene-level effects using the sequence kernel association test (SKAT. Although none of the association p-values were statistically significant after adjustment for multiple comparisons, SNPs in CYP1B1 were strongly associated with KIT exon 11 codon 557-8 deletions (OR = 1.9, 95% CI: 1.3-2.9 for rs2855658 and OR = 1.8, 95% CI: 1.2-2.7 for rs1056836 and wild type GISTs (OR = 2.7, 95% CI: 1.5-4.8 for rs1800440 and OR = 0.5, 95% CI: 0.3-0.9 for rs1056836. CYP1B1 was also associated with these mutations categories in the SKAT analysis (p = 0.002 and p = 0.003, respectively. Other potential risk variants included GSTM1, RAD23B and ERCC2. This preliminary analysis of inherited genetic risk factors for GIST offers some clues about the disease's genetic

  13. Peso e rendimento dos componentes do peso vivo de cordeiros terminados em confinamento com dietas contendo proporções crescentes de resíduo úmido de cervejaria Weight and yield of liveweight components of feedlot finish lambs fed diets with increasing proportions of wet brewery residue

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    M.A. Brochier

    2008-10-01

    Full Text Available Avaliou-se o efeito de dietas contendo proporções crescentes de resíduo úmido de cervejaria sobre o peso e proporção dos componentes do peso vivo de cordeiros terminados em confinamento. Foram utilizados 25 cordeiros, machos, não-castrados, da raça Texel, distribuídos aleatoriamente em cinco tratamentos compostos por proporções de 0%, 25%, 50%, 75% e 100% de substituição do alimento concentrado por resíduo úmido de cervejaria. Utilizou-se dieta composta de feno de Tifton-85 e mistura concentrada em uma relação volumoso:concentrado de 40:60, na matéria seca. O alimento concentrado foi constituído por milho desintegrado, farelo de soja, mistura mineral e resíduo úmido de cervejaria, sendo que suas proporções variaram de acordo com os tratamentos. Houve redução linear dos pesos de sangue, patas, cabeça, fígado, pulmão e baço, e da proporção de fígado, à medida que se elevou a proporção do resíduo úmido de cervejaria nas dietas. A proporção, em relação ao peso vivo, de rúmen/retículo e do trato gastrintestinal, com conteúdo, e do conteúdo gastrintestinal aumentou linearmente, enquanto os pesos de rúmen/retículo, abomaso, intestino delgado e do trato gastrintestinal, sem conteúdo, diminuíram linearmente com o aumento da proporção do resíduo nas dietas. A proporção de rúmen/retículo, sem conteúdo, foi influenciada de forma quadrática.The effect of diets with increasing proportions of wet brewery residue on the weight and proportion of live weight components of feedlot finished lambs was evaluated. Twenty-five non-castrated Texel male lambs were randomly allotted into five groups, consisting in the replacement of the concentrate by wet brewery residue; at the proportions of 0%, 25%, 50%, 75%, and 100%. Diet composition was Tifton-85 hay and concentrate mixture, in a relation roughage:concentrate of 40:60, based on dry matter (DM. The concentrate was composed of ground corn, soybean meal, mineral

  14. Weight and yield of non-carcass components of Morada Nova lambs fed with different levels of metabolizable energyPeso e rendimento dos componentes não-carcaça de ovinos Morada Nova alimentados com diferentes níveis de energia metabolizável

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    Danilo de Araújo Camilo

    2012-12-01

    Full Text Available The objective of this study was to evaluate the effect of different metabolizable energy (ME levels on weight of gastrointestinal content, weight and yield of the internal organs and gastrointestinal compartments of Morada Nova growing lambs. Thirty-two animals, non-castrated, with average body weight of 12.12 ± 1.69 kg and two months old approximately, were used. The animals were distributed into four different metabolizable energy (1.28; 1.72; 2.18 and 2.62 Mcal/kg DM levels, in randomized block design with eight replicates per treatment. Tifton 85 hay was used as roughage. There was no effect of energy levels (P > 0.05 on weight of gastrointestinal content. Increased linear effect (P Objetivou-se com o presente estudo avaliar o efeito de diferentes níveis de energia metabolizável (EM sobre: peso do conteúdo do trato gastrintestinal, peso e rendimento dos órgãos internos e compartimentos gastrintestinais em ovinos Morada Nova em crescimento. Foram utilizados 32 animais, não castrados, com peso corporal médio de 12,12 ± 1,69 kg e, aproximadamente, dois meses de idade. Os animais foram distribuídos em quatro diferentes níveis de EM (1,28; 1,72; 2,18 e 2,62 Mcal/kg de MS, em delineamento em blocos casualizados, com oito repetições por nível de EM. O feno de Tifton 85 foi utilizado como volumoso. Não foi observado efeito (P > 0,05 dos níveis de energia sobre o peso do conteúdo gastrintestinal. Verificou-se efeito linear crescente (P < 0,05 dos níveis de EM sobre os pesos do coração, PTEL (pulmões, traqueia, esôfago e língua, fígado e baço, expressos em kg. Em relação aos compartimentos do trato gastrintestinal foi observado efeito linear crescente (P < 0,05 dos níveis de EM somente sobre o rúmen-retículo, em %, e intestino delgado, em kg. As gorduras perirrenal, omental e mesentérica foram influenciadas pelos níveis de EM (P < 0,05, com incremento linear para os pesos em kg e %. O aumento dos níveis de EM das ra

  15. New methodologies for old problems: tridimensional gastrointestinal organoids and guts-on-a-chip

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    Marna Eliana Sakalem

    2018-01-01

    Full Text Available Objectives: The present review intended to present a critical overview of the methodological and experimental advances concerning tridimensional cell culture models within the scope of gastrointestinal research. Methods: A literature review was performed and some of the main published articles in the area were mentioned. Main results: Classic studies and high impact results were presented, starting from the pioneer works with gastrointestinal organoids, with a small gut organoid, to the achievement of guts-on-a-chip and multi-organ-chips. It was also discussed which implications the construction of such co-cultures bring, as well as future applications arising from these new methodologies. Conclusions: Despite the still discrete number of publications, in quantitative terms, there are qualitative promising and consistent results addressing physiopathological aspects and new therapeutic perspectives of tridimensional in vitro cultures in the gastroenterology field. It is expected, thus, that such new methodological approaches, including organoids and guts-on-a-chip, may contribute decisively to the advance in knowledge on basic aspects, as well as on the translation to new therapeutic approaches in gastrointestinal diseases. Resumo: Objetivos: A presente revisão visou apresentar uma abordagem crítica dos avanços metodológicos e experimentais referentes a modelos de cultura celular tridimensionais no âmbito do sistema gastrintestinal. Métodos: Foi realizada revisão da literatura com ênfase nos principais artigos publicados na área. Resultados principais: São apresentados trabalhos clássicos e resultados de maior impacto, desde os trabalhos pioneiros com organoides do sistema gastrintestinal, com intestino delgado, até a obtenção de guts-on-a-chip e multi-organ-chips. Discutiu-se, ainda, as implicações decorrentes da elaboração de tais co-culturas, bem como as futuras aplicações decorrentes dessas novas metodologias. Conclus

  16. Papel da ranitidina como meio de aprimorar a qualidade do exame de colangiopancreatografia por ressonância magnética The role of ranitidine in the enhancement of imaging quality in magnetic resonance cholangiopancreatography

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    Lucas Rios Torres

    2013-04-01

    Full Text Available OBJETIVO: Avaliar o impacto da ranitidina por via oral na qualidade do exame de colangiopancreatografia por ressonância magnética (CPRM. MATERIAIS E MÉTODOS: Trinta e dois pacientes realizaram CPRM com aquisições 3D e 2D, com três estratégias de supressão do sinal líquido gastrintestinal: a apenas em jejum; b 12 horas após ingerir 300 mg de ranitidina; c após a ingestão de solução de gadolínio. Três observadores avaliaram os estudos, atentos para o grau de visualização da árvore biliopancreática. Foi medida a concordância interobservador com o teste kappa. A diferença entre técnicas e formas de aquisição foi avaliada pela média da soma dos escores de graduação. RESULTADOS: As três estratégias de supressão do sinal líquido gastrintestinal apresentaram elevada reprodutibilidade. A supressão do sinal líquido gastrintestinal com a ranitidina foi semelhante ao jejum e ambas foram piores do que a solução de gadolínio. As aquisições 3D superaram a 2D apenas na visualização do ducto cístico e da vesícula biliar, sendo inferior ou equivalente nos demais segmentos ductais biliopancreáticos. CONCLUSÃO: O uso da ranitidina não parece justificado para aprimorar a avaliação da árvore biliopancreática em exames de CPRM. A CPRM 2D apenas em jejum permite a visualização ductal com elevada qualidade e reprodutibilidade na maioria dos casos.OBJECTIVE: To assess the impact of oral ranitidine on the imaging quality in magnetic resonance cholangiopancreatography (MRCP. MATERIALS AND METHODS: Thirty-two patients underwent MRCP with 3D and 2D acquisitions, and three strategies for suppression of the gastrointestinal fluid signal: a only at fasting; b 12 hours after ingestion of 300 mg ranitidine; c after oral administration of gadolinium solution. Three observers reviewed the images with a focus on the degree of visualization of the biliopancreatic tree. The interobserver agreement was evaluated with the kappa test

  17. Componentes não-integrantes da carcaça de novilhos não-castrados ou castrados terminados em confinamento e abatidos aos 16 ou 26 meses de idade Non-carcass components of castrate and non-castrated cattle finished in feedlot and slaughtered at 16 or 26 months of age

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    Fernando Kuss

    2008-10-01

    Full Text Available Foram avaliados os componentes não-integrantes da carcaça de novilhos terminados em confinamento e abatidos aos 16 (superjovem ou 26 (jovem meses de idade. A dieta foi formulada com 50% de volumoso e 50% de concentrado e continha 11,8% de proteína bruta e 2,83 Mcal de energia digestível por kg de matéria seca. Animais superjovens apresentaram maior rendimento de corpo vazio (92,39 versus 89,76% para os jovens, como resultado de seu menor conteúdo gastrintestinal (35,23 versus 53,46 kg para os jovens. Animais não-castrados apresentaram maior peso de cabeça (13,84 versus 12,35 kg, patas (11,12 versus 8,96 kg e couro (46,44 versus 37,71 kg em comparação aos castrados, o que está relacionado ao seu maior peso corporal (541,26 versus 445,47 kg. Observou-se influência da interação categoria x condição sexual sobre o peso absoluto dos órgãos vitais (coração, fígado e pulmões e dos componentes do trato gastrintestinal. O peso total de órgãos vitais e do trato gastrintestinal foi maior nos animais não-castrados, mas deixou de ser significativo quando ajustado para peso de corpo vazio (PCV e de abate (PA. Animais superjovens apresentaram maior peso absoluto das gorduras interna (25,91 versus 20,13 kg e de toalete (13,96 versus 10,98 kg. A castração dos animais resultou em maior participação de gordura interna calculada em relação ao peso de corpo vazio e ao peso de abate.The non-carcass components of castrated and non-castrated cattle (sex condition finished in feedlot and slaughtered at 16 (super young or 26 (young months of age (animal category were evaluated. The diet was formulated to contain 11.8% of CP and 2.83 Mcal/kg DM of DE with 50:50 forage to concentrate ratio (%MS. Super young animals showed higher of empty body dressing percentage (92.39 versus 89.76%, as a result of their lower gastrointestinal content (35.23 versus 53.46 kg as compared to the young animals. Non-castrate animals showed higher head weight (13

  18. Efect of verminosis on goat immune response/ Efeito da verminose na resposta imune em caprinos

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    Maurício Garcia

    2002-05-01

    Full Text Available The purpose of this work was to evaluate the immune response in goats with different degrees of gastrintestinal nematode infection. Ninety adult animals naturally infected were grouped according to the total egg count per feces gram (EPG: group I from zero to 500 EPG, group II from 501 to 2000 and group III above 2000. The parameters studied were serum total protein (STP, evaluated by biuret method; globulin (Glob, calculated by the difference between STP and serum albumin; gammaglobulin (Gglob, estimated throughout electrophoresis; immunoglobulin (Ig, estimated by turbidometry test with ZnSO4 and absolute lymphocyte count (Lymp / ml. It was found statistically decrease in three parameters (STP, Ig and Lymp / ml for group III. For Glob and Gglob, the decrease found was not statistically significant. These results show a depressor effect of nematode infection on humoral immune system. The intense dispersion of Glob and Gglob data can explain the not significant decrease found in those parameters. It was concluded that goats with intense nematode infection (above 2000 EPG can show immunedepression, with impairment of lymphocyte count and serum antibody level.O objetivo deste trabalho foi estudar a resposta imunológica em caprinos com vários graus de verminose gastrintestinal. Foram utilizados 90 animais adultos, naturalmente infectados, divididos em três grupos de 30 animais cada e separados segundo a contagem de ovos por grama de fezes (OPG: grupo I de zero a 500 OPG; grupo II de 501 a 2.000 OPG e o grupo III maior que 2.000 OPG. As variáveis estudadas foram: a dosagem de proteínas séricas totais (PST, avaliada pelo método do biureto; globulinas (Glob, calculada pela diferença entre a proteína total e a albumina sérica; gamaglobulinas (Gglob, medidas pela eletroforese; imunoglobulinas (Ig, dosadas pelo teste da turbidimetria com ZnSO4 e a contagem absoluta de linfócitos (Linfo/mL. Observou-se que em três destes parâmetros (PST, Ig e

  19. Contribuição da tomografia de coerência óptica de 820 nm na distrofia granular corneana: relato de caso Contribution of 820 nm optical coherence tomography in granular corneal dystrophy: case report

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    Beatriz de Abreu Fiuza Gomes

    2008-10-01

    Full Text Available O objetivo deste trabalho é correlacionar os dados clínicos de um caso de distrofia granular com o exame de tomografia de coerência óptica (OCT de 820 nm de modo a determinar o nível intra-estromal dos depósitos corneanos. É relatado um caso de distrofia granular em paciente de 38 anos do sexo masculino. Foi realizado exame oftalmológico completo e OCT para documentação do caso. O aparelho utilizado foi o Stratus OCT III, originalmente desenvolvido para avaliação do segmento posterior. A acuidade visual corrigida foi de 20/50 em ambos os olhos. À biomicroscopia, foram observadas opacidades em "floco de neve" em diferentes níveis do estroma corneano bilateral e de forma simétrica. A avaliação pelo OCT revelou múltiplos pontos hiperreflectivos nas camadas superficiais e profundas do estroma. Foi possível acessar a anatomia morfológica da córnea através de cortes seriados realizados pelo Stratus OCT III e confirmar a profundidade dos depósitos corneanos.The purpose of this case report is to correlate clinical features of granular dystrophy using 820 nm optical coherence tomography (OCT in order to determine the depth of intrastromal corneal deposits. We report a case of a 38-year-old man with granular dystrophy. After complete ophthalmologic examination the patient was submitted to OCT, using the Stratus OCT III, originally proposed for studying disorders of the posterior segment. Best-corrected visual acuity was 20/50 in both eyes. Biomicroscopy revealed bilateral "snowflake"opacities in different levels of the stromal layer. OCT disclosed multiple hiperreflective dots in anterior and deeper stromal layers. It was possible to assess the morphology of the cornea and to determine the depth of the corneal deposits with serial cross-sectional OCT scans using the Stratus OCT III.

  20. Bacterial ecology of tilapia fresh fillets and some factors that can influence their microbial quality Ecologia bacteriana de filés frescos de tilápia e de pontos capazes de influenciar a sua qualidade microbiológica

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    Cleube Andrade Boari

    2008-12-01

    Full Text Available The purpose of research was to investigate the bacterial ecology of tilapia (Oreochromis niloticus fresh fillets and some factors that can influence its microbial quality. Samples of fish cultivation water (n = 20, tilapia tegument and gut (n = 20 and fresh fillets (n = 20 were collected in an experimental tilapia aquaculture located in the city of Lavras, Minas Gerais, Brazil. Staphylococcus spp., Aeromonas spp., Enterococcus spp. and Enterobacteriaceae were quantified using selective plating. For the enumeration of Pseudomonas spp., the most probable number technique (MPN was utilized. Bacterial colonies (n = 198 were identified by Gram strain and biochemical tests. Aeromonas spp., Pseudomonas spp., Enterococcus spp. and Enterobacteriaceae were found in the cultivation water (water from a fishpond cultivation, tegument, gut, and fresh fillets. Staphylococcus spp. was not isolated in the cultivation water. Salmonella spp. was not detected. The count variable of 10 to 10³ CFU or MPN.(g or mL-1. Associated to freshwater tilapia fillet processing, there is a large variety of microorganisms related to foodborne illnesses and fish products deterioration.A presente pesquisa foi conduzida com o objetivo de se investigar a ecologia microbiana de filés frescos de tilápia (Oreochromis niloticus e de pontos capazes de influenciar em sua qualidade microbiológica. Para sua condução, amostras de água de cultivo (n = 20, tegumento e trato gastrintestinal (n = 20 e filés frescos (n = 20 foram coletados em um sistema de produção aqüícola de água doce localizado em Lavras, Minas Gerais, Brasil. Staphylococcus spp., Aeromonas spp., Enterococcus spp., Enterobacteriaceae foram quantificados através de plaqueamento seletivo. Pseudomonas spp. foi enumerada através da técnica do número mais provável. Colônias (n = 198 foram identificadas por coloração de Gram e testes bioquímicos. Aeromonas spp., Pseudomonas spp., Enterococcus spp. e

  1. Cinética de fósforo com modelos matemáticos em ovinos adultos Phosphorus kinetics using mathematical models for adult sheep

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    Helder Louvandini

    2007-10-01

    Full Text Available O objetivo deste trabalho foi avaliar, por meio de modelos matemáticos, o metabolismo de fósforo (P em ovinos adultos suplementados com teores crescentes de farinha de ossos calcinados com 0, 1, 2 e 3 g de P por animal por dia. Esses valores representaram diferentes tratamentos, adicionados à dieta basal com 225 g de concentrado e feno ad libitum. Foram utilizados 16 ovinos, Suffolk, com peso vivo de 38,2±4,35 kg e idade média de 18 meses, mantidos em gaiolas individuais. Após 21 dias, 7,4 MBq do radiofósforo (32P foram injetados em cada ovino, e foram coletados sangue, fezes e urina por oito dias, a fim de determinar o fluxo de P entre três compartimentos: trato gastrintestinal, compartimento central (sangue e tecidos (moles e ósseo. Houve relação linear positiva entre o P consumido e o P absorvido, excretado nas fezes, urina e retenção. A perda endógena fecal de P foi exponencial com o aumento de P da dieta. A elevação do teor de P da dieta interfere nas trocas do mineral para o trato gastrintestinal e urinário, o que indica que 0,82 g de P por dia são suficientes para mantença dessa categoria animal.An experiment was carried out to measure the phosphorus (P flows in adult sheep by mathematical model. The work was conducted with 16 Suffolk sheep, live weight of 38.2±4.35 kg and 18-month aged, kept in individual cage to determine the effect of phosphorus (P intake by adding bone meal (0, 1, 2 and 3 g P per animal per day in the basal diet (225 g the concentrate and hay ad libitum. After 21 days, the lambs were injected with 7.4 MBq of 32P to trace the flows of P in the three compartments gastrointestinal tract, central (blood and tissues (soft and bone. There was a positive relationship between P intake and P absorbed, P faeces, P urinary and P retained. Fecal endogenous loss of the P was exponentially related to P intake. The high levels of P on diet affected the exchanges between gastrointestinal and urinary tract. Results

  2. Semi-obstrução intestinal por esclerodermia: relato de caso

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    Juliana Mendes Cardoso

    2006-06-01

    Full Text Available A esclerodermia ou esclerose sistêmica progressiva é uma doença auto-imune de causa desconhecida que se caracteriza por fibrose da pele, vasos sanguíneos e de alguns outros órgãos, como os pulmões, coração, rins e trato gastrintestinal. Sintomas atribuíveis ao comprometimento gastrintestinal podem estar presentes em até 50% dos pacientes, sendo os mais freqüentes, relacionados às manifestações esofagianas e anorretais. Anormalidades na motilidade intestinal com freqüência levam a desnutrição, supercrescimento bacteriano e quadro de pseudo-obstrução ou mesmo semi-obstrução intestinal. É apresentado um caso de paciente com esclerodermia há 43 anos, evoluindo com quadro de semi-obstrução, apresentando distensão abdominal, cólicas recorrentes e desnutrição grave. Sem resposta ao tratamento clínico foi submetida à cirurgia que evidenciou quadro obstrutivo por comprometimento ileal, o qual foi tratado por bypass íleo-cólico. Lesão intestinal por esclerodermia levando a quadro de obstrução é raramente descrita na literatura médica e, portanto, o tratamento de escolha ainda não foi definido.Scleroderma or progressive systemic sclerosis (PSS is a self-immune illness of unknown cause that is characterized by fibrosis of the skin, blood vessels and some other tissues like the lungs, heart, kidneys and gastrointestinal system. Attributable symptoms to the gastrointestinal involvement can be present in up to 50% of the patients, esophageal and anorectal manifestations being more frequent. Abnormalities in the intestinal motility frequently lead to malnutrition, bacterial over-growth and intestinal pseudo-obstruction. We report a case of scleroderma with intestinal pseudo-obstruction presenting chronic abdominal cramps, bloating and malnutrition with no response to clinical approach. Patient underwent surgery with diagnosis of intestinal obstruction by annular ileal fibrosis treated by ileocolic bypass. Intestinal

  3. Fronteiras do pulmão – Relação com o sistema gastrenterológico

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    C. Teles Martins

    2010-01-01

    Full Text Available Resumo: A interacção entre os sistemas respiratório e gastrintestinal é reconhecida há várias décadas, sendo motivada por mecanismos anatómicos, fisiológicos e patológicos diversos.Se é certo que a relação de algumas entidades nosológicas acorre, intuitivamente, ao pneumologista, como é o caso da asma e o refluxo gastroesofágico, outras interacções patológicas tendem a ser subdiagnosticadas, não só pela sua complexidade fisiológica, mas também pela sua menor frequência (doenças da via aérea motivadas pela colite ulcerosa e doença de Crohn, por exemplo.É objectivo do presente artigo rever os mecanismos anatomofisiológicos, patológicos, clínicos e terapêuticos responsáveis pela complexa interacção entre o pulmão e o sistema gastrintestinal. Abstract: The relation between the respiratory and gastrointestinal systems has been long recognized and depends on various anatomical, physiological and pathological mechanisms.The certain recognition of some interactions, such as the relation between asthma and gastroesophageal reflux, is more or less intuitive to the pulmonogist, whereas other areas of confluence are more easily missed, such as the relation between airway disorders and inflammatory bowel disease.The purpose of this article is to review the interaction between the lung and the gastrointestinal systems, as far as anatomy, physiology, pathology, clinical manifestations and therapeutical options go. Palavras-chave: Pulmão, aparelho digestivo, Key-words: Lung, gastrointestinal system

  4. Fronteiras do pulmão – Relação com o sistema gastrenterológico

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    C. Teles Martins

    2010-01-01

    Full Text Available Resumo: A interacção entre os sistemas respiratório e gastrintestinal é reconhecida há várias décadas, sendo motivada por mecanismos anatómicos, fisiológicos e patológicos diversos.Se é certo que a relação de algumas entidades nosológicas acorre, intuitivamente, ao pneumologista, como é o caso da asma e o refluxo gastroesofágico, outras interacções patológicas tendem a ser subdiagnosticadas, não só pela sua complexidade fisiológica, mas também pela sua menor frequência (doenças da via aérea motivadas pela colite ulcerosa e doença de Crohn, por exemplo.É objectivo do presente artigo rever os mecanismos anatomofisiológicos, patológicos, clínicos e terapêuticos responsáveis pela complexa interacção entre o pulmão e o sistema gastrintestinal.Rev Port Pneumol 2010; XVI (1: 133-148 Abstract: The relation between the respiratory and gastrointestinal systems has been long recognized and depends on various anatomical, physiological and pathological mechanisms.The certain recognition of some interactions, such as the relation between asthma and gastroesophageal reflux, is more or less intuitive to the pulmonogist, whereas other areas of confluence are more easily missed, such as the relation between airway disorders and inflammatory bowel disease.The purpose of this article is to review the interaction between the lung and the gastrointestinal systems, as far as anatomy, physiology, pathology, clinical manifestations and therapeutical options go.Rev Port Pneumol 2010; XVI (1: 133-148 Palavras-chave: Pulmão, aparelho digestivo, Key-words: Lung, gastrointestinal system

  5. Tumor desmoplásico de pequenas células redondas abdominal da infância: relato de caso Abdominal desmoplastic small round cell tumor of childhood: case report

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    Ulysses dos Santos Torres

    2010-02-01

    Full Text Available O tumor desmoplásico de pequenas células redondas (TDPCR é uma neoplasia rara e altamente agressiva, que afeta predominantemente jovens do sexo masculino. Relata-se um caso de TDPCR em um paciente do sexo masculino, de 11 anos, com acometimento intra-abdominal marcado por volumosa massa retroperitoneal em hipocôndrio esquerdo. O estudo histológico da massa revelou presença de blocos de pequenas células tumorais redondas e azuis, envoltas por estroma desmoplásico; a análise imuno-histoquímica evidenciou positividade para desmina, WT-1 e citoceratinas. Após o diagnóstico, o paciente foi submetido a tratamento quimiorradioterápico, tendo evoluído a óbito durante o 24º mês de acompanhamento.Desmoplastic small round cell tumor (DSRCT is a rare and highly aggressive neoplasm, which predominantly affects young males. We report a case of DSRCT affecting an 11-year-old male patient, with intra-abdominal involvement characterized by a large retroperitoneal mass in left hypochondrium. Histological examination of the mass showed the presence of clusters of small blue round tumor cells surrounded by a dense desmoplastic stroma. Immunohistochemical analysis disclosed a positive reaction to desmin, WT-1 and cytokeratins. After diagnosis, the patient underwent chemo radiotherapy treatment, but died at the 24th month of follow-up.

  6. Parotiditis por Streptococcus Pyogenes: Presentacion de un caso

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    Zoila del S. López-Díaz

    1995-08-01

    Full Text Available La glándula parótida es generalmente afectada por procesos inflamatorios. Su etiología se debe a infecciones primarias de la glándula o como complicación de infecciones sistémicas. Se reporta el Stafilococcus aureus como el agente causal más frecuente de parotiditis aguda supurada, y se señalan además otras bacterias y virus. Se presenta un niño de 9 años de edad con un proceso supurativo agudo de la parótida izquierda de un mes de evolución, con salida de abundante pus por el conducto de Stenon. Se realizó cultivo de la secreción e identificación de Streptococcus B hemolítico grupo A, a pesar de haber recibido antibioticoterapia previa. Se utilizó ampicillina y se tuvo en cuenta la sensibilidad in vitro; no presentó mejoría clínica, por lo que se decidió el empleo de la sialografía como alternativa terapéutica en este caso. Se obtuvo la resolución del proceso supurativo infeccioso y además se evidenció en este estudio la pérdida del estroma parotídeo.

  7. Morphometric analysis of the thymus of puppies infected with the Snyder Hill Strain of canine distemper virus Análise morfométrica do timo de cães filhotes infectados com a amostra Snyder Hill do vírus de cinomose canina

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    C.M. Alves

    2006-08-01

    Full Text Available The thymic morphometry analysis was used for determining apoptosis and atrophy of the thymus of eight puppies inoculated with canine distemper virus (CDV. Three healthy dogs were used as negative controls. Sections, 5µm thick, were stained by HE and Shorr, and the latter were evaluated by morphometry. CDV nucleoprotein was detected by immunohistochemistry. Morphometric results confirmed lymphoid hypotrophy in CDV inoculated dog thymuses, more stroma, less parenchyma and higher apoptotic index/field than negative control (not inoculated puppies. Apoptosis plays a role in the mechanism of thymus atrophy that develops in canine distemper.Determinaram-se a apoptose e a atrofia no timo de oito cães novos, inoculados experimentalmente com o vírus de cinomose. Três cães saudáveis foram usados como controle negativo. Secções coradas pelo Shorr foram avaliadas por morfometria. A nucleoproteína viral foi detectada por imunoistoquímica. Os resultados morfométricos confirmaram a hipotrofia e mostraram que o timo dos cães inoculados tinha mais estroma, menos parênquima e maior índice apoptótico/campo que o dos animais-controle. Pode-se concluir que a apoptose desempenha importante papel no mecanismo de hipotrofia tímica que se desenvolve na cinomose.

  8. Correlação entre os Aspectos Laparoscópicos e os Achados Histológicos das Lesões Endometrióticas Peritoneais Correlation Between Laparoscopic Aspects and Histologic Findings in Peritoneal Endometriotic Lesions

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    Francesco Antonio Viscomi

    2002-03-01

    Full Text Available Objetivos: avaliar a correlação entre os aspectos laparoscópicos e os achados histológicos estromais incluindo, a profundidade da lesão endometriótica peritoneal, e na relação com a teoria evolutiva da endometriose. Métodos: foram selecionadas para o estudo 67 pacientes submetidas à laparoscopia por algia pélvica, infertilidade, tumor anexial e outras indicações. A avaliação laparoscópica baseou-se no aspecto visual do implante suspeito de endometriose peritoneal, o qual foi biopsiado. De acordo com o aspecto laparoscópico, as lesões foram agrupadas em: grupo V - lesões vermelhas, grupo N - lesões negras e grupo B - lesões brancas. Os parâmetros histológicos estudados foram: profundidade da lesão, presença de hemossiderina no estroma, vascularização estromal e presença de fibrose no estroma. Resultados: a profundidade da lesão mostrou diferenças estatisticamente significantes entre os grupos de estudo. As lesões vermelhas mostraram-se superficiais em 100% dos casos. As lesões negras apresentaram-se superficiais em 55,6%, intermediárias em 38,9% e profundas em 5,5%. As lesões brancas mostraram-se superficiais em 28%, intermediárias em 68% e profundas em 4%. A presença de hemossiderina no estroma se mostrou equivalente nos 3 grupos. A presença de vasos no estroma da lesão endometriótica, que foi classificada de I a III de acordo com a quantidade, demonstrou diferenças significantes entre os 3 grupos, sendo que a vascularização exuberante (grau III esteve presente em 60% das lesões vermelhas e em 10% das lesões brancas. A presença de tecido fibrótico na lesão endometriótica apresentou diferenças estatisticamente significantes nos 3 grupos de estudo, sendo mais freqüente no grupo B (lesões brancas, com 70,6%. Conclusão: as variáveis analisadas nos diferentes grupos de estudo demostraram diferença significantes entre os grupos, reforçando a teoria evolutiva da endometriose peritoneal.Purpose: to

  9. MACIEZ DA CARNE BOVINA

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    Antonio Bento Mancio

    2006-10-01

    Full Text Available Dentre as características de qualidade da carne bovina, a maciez assume posição de destaque, sendo considerada a característica organoléptica de maior influência na aceitação da carne por parte dos consumidores. A dureza da carne pode ser dividida em dureza residual, causada pelo tecido conjuntivo e outras proteínas do estroma, e dureza de actomiosina, causada pelas proteínas miofibrilares. Dentre os fatores que influenciam a maciez da carne, podem ser destacados a genética, a raça, a idade ao abate, o sexo, a alimentação, o uso de agentes hormonais (?-adrenérgicos e os tratamentos post-mortem. A qualidade final da carne é resultante de tudo o que aconteceu com o animal durante toda a cadeia produtiva. Devem-se assegurar procedimentos adequados de transporte, armazenamento, manipulação, exposição e preparo da carne, a fim de se obter um produto de melhor qualidade. PALAVRAS-CHAVE: Calpaínas, calpastatina, qualidade da carne, rigor mortis, tecido muscular.

  10. ESTUDIO MORFOMÉTRICO Y ESTEREOLÓGICO E LAS ALTERACIONES DE LA GLÁNDULA PARÓTIDA E HAMSTERS SOMETIDOS A HIPERVITAMINOSIS A

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    Luiz Guilherme BRENTEGANI

    2009-07-01

    Full Text Available

    RESUMEN: Se han estudiado las alteraciones causadas por hipervitaminosis A en la parótida del hamster, mediante métodos cariométricos y estereológicos. Los ácinos y ductos de la glándula del animal tratado mostraron núcleos más chicos y picnóticos. Estereologicamente se observó que la parótida del animal tratado presenta densidad de volumen más chica para ácinos y ductos estriados, diámetro y espesor de la pared más chicos para ácinos y densidad volumétrica más grande para el estroma conjuntivo. Se sugiere que el exceso de vitamina A puede actuar sobre la parótida de dos maneras: a Directamente sobre el epitelio glandular, provocando las alteraciones estructurales y funcionales; b indirectamente, alterando los niveles de las hormonas responsables por la manutención estructural y funcional normal de las glándulas salivares. PALABRAS-CLAVE: Hipervitaminosis A; parótida; hamster.

  11. Cross-linking da cornea: protocolo padrão

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    Marcony R. Santhiago

    Full Text Available RESUMO O objetivo desta revisão é de determinar as indicações e eficácia da cirurgia que promove novas ligações covalentes entre as fibras de colágeno da córnea, conhecida como Cross-Linking (CXL, assim como esclarecer seus objetivos. O ceratocone é uma doença ectasica da córnea, bilateral, assimétrica, que, principalmente, cursa com encurvamento e afinamentos progressivo, e se inicia em geral na segunda década de vida. O uso primário do CXL tem sido na interrupção da progressão do Ceratocone. Apesar do conhecido encurvamento no estroma da córnea ocorrer nesses pacientes, a fisiopatologia por trás do ceratocone ainda é desconhecida e parece ser multifatorial. Pela evidencia literária disponível até o momento, o CXL da córnea esta, portanto indicado nos pacientes com doença em progressão. Concluímos que existe evidencia suficiente para afirmar que o CXL da córnea é eficaz na estabilização da doença ectásica da cornea.

  12. Uterine leiomyoma in chimpanzee (Pan troglodytes Leiomioma uterino em chimpanzé (Pan troglodytes

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    A.E. Silva

    2006-02-01

    Full Text Available Uma chimpanzé de 22 anos de idade foi necropsiada com histórico clínico de anorexia, vômitos freqüentes e desidratação conseqüentes à gastrite iatrogênica. Macroscopicamente, o útero apresentava-se aumentado de volume, com o lúmen totalmente ocluído por nódulos firmes, esbranquiçados e coalescentes que se estendiam para o miométrio. Histologicamente, os nódulos eram constituídos por leiomiócitos bem diferenciados dispostos em várias direções e com coloração característica pelo tricrômio de Gomori e Masson. Pela imunoistoquímica, as células neoplásicas apresentavam marcação forte e difusa de receptores para progesterona e estrógeno, assim como de actina alfa de músculo liso. Algumas células neoplásicas e o estroma apresentavam marcação para vimentina e poucas células neoplásicas foram positivas para MIB-1. Com base nas características mosrfológicas e imunoistoquímicas foi firmado o diagnóstico de leiomioma uterino.

  13. Tumor de células da granulosa com metástases numa gata

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    Márcia Regina Giacóia

    1999-01-01

    Full Text Available As características clínicas, macroscópicas e microscópicas de um tumor de células da granulosa no ovário de uma gata de 2 anos de idade são descritas neste trabalho. Essa neoplasia é rara em gatos, principalmente devido à idade apresentada pelo animal. O diagnóstico foi feito clinicamente através de exame ultra-sonográfico. O tumor, uma massa cística na região do ovário esquerdo, metastatizou para o epíploo e para os pulmões. As células tumorais expressaram vimentina e arranjavam-se num padrão sarcomatoso e difuso, sustentado por fino estroma fibrovascular. A presença de sinais clínicos, como perda de pêlos e repetição de estros, é indicativa de síndrome paraneoplásica ortoendócrina, devido à excessiva estimulação estrogênica. A existência desse tipo de tumor deve ser considerada no diagnóstico diferencial de distúrbios comportamentais em gatas.

  14. Choroid plexus carcinoma in a cow Carcinoma de plexo coróide em um bovino

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    Fabiano José Ferreira de Sant'Ana

    2009-10-01

    Full Text Available A red, firm 3.5x3.0x3.0cm mass was found within the right lateral ventricle, compressing the hippocampus and thalamus of the brain of a 4-year-old cow. The pituitary was enlarged and firm. Histologically, both the brain and pituitary masses consisted of moderately pleomorphic epithelial cells arranged as rosettes or sheets supported by a delicate fibrovascular stroma. Based on anatomical localization, histopathological and immunohistochemical findings, a diagnosis of choroid plexus carcinoma with pituitary metastasis was made.Um massa vermelha e firme de 3,5x3,0x3,0cm foi observada no ventrículo lateral, comprimindo o hipocampo e tálamo do cérebro de uma vaca de quatro anos de idade. A pituitária estava aumentada de volume e firme. Histologicamente, tanto a massa do cérebro, quanto da pituitária, consistiam de células epiteliais moderadamente pleomórficas, arranjadas em rosetas ou cordões e apoiadas em um delicado estroma fibrovascular. Com base na localização anatômica e nos achados histopatológicos e imuno-histoquímicos, foi realizado um diagnóstico de carcinoma de plexo coróide com metástase para a pituitária.

  15. Imágenes ecográficas de la mola hidatiforme parcial en el segundo trimestre del embarazo Ultrasound imaging of partial hydatidiform mole in the second trimester of pregnancy

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    Marina Jover Labiste

    2012-01-01

    Full Text Available Se describe el caso clínico de una paciente de 27 años de edad y 18 semanas de gestación, ingresada en el Servicio de Obstetricia del Hospital Ginecoobstétrico Provincial "Mariana Grajales Coello" de Santiago de Cuba, por presentar cifras tensionales elevadas, cefalea y dolor en bajo vientre. Los exámenes complementarios efectuados confirmaron que se trataba de una mola hidatiforme parcial, por lo cual se legró la cavidad uterina y se extrajeron pequeños fragmentos de estroma endometrial para estudio anatomopatológico. Se indicó seguimiento médico por consulta externa y se citó a los 21 días para el control y la evaluación de su estado general.The case report of a 27 year-old patient with 18 weeks gestation, admitted to the Obstetrics Department of "Mariana Grajales Coello" Provincial Gynecology and Obstetrics Hospital of Santiago de Cuba due to high blood pressure, cephalea and pain in lower abdomen is described. Additional tests confirmed a partial hydatidiform mole, so that uterine curettage was performed and small fragments of endometrial stroma were removed for pathological study. Outpatient medical monitoring was recommended and the patient had an appointment at 21 days for controlling and evaluating her general state.

  16. Mola hidatiforme en un embarazo ectópico. Presentación de un caso Hydatid mole in an ectopic pregnancy

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    Vladimir Díaz Noda

    2005-09-01

    Full Text Available La Mola Hidatiforme se caracteriza por la presencia de anormalidades de las vellosidades coriónicas que consisten en grados variables de proliferación trofoblásticas y de edema del estroma de las vellosidades.Su incidencia varia de manera importante en las diversas regiones del mundo, no ocurriendo así con el embarazo ectópico que ha tenido un aumento significativo en todo el planeta. Pero la asociación de estas dos entidades es muy rara. Presentamos un caso de 35 años de edad donde observamos esta rara asociación, en el que se realizó salpingectomia derecha con evolución favorable.The Hydatiform mole is characterized by the presence of abnormalities of chorionic vellus which consist of variables degrees of trophoblastic proliferation and edema of the vellus stroma. Its incidence varies very importantly in the varuopus regions all over the world, which is not the same for the ectopic pregnancy that has increased significantly around the globe. The association between these two entities is uncommon. We presented a case with a 35 year - old person and observed this uncommon association, and performed a right salpingectomy with favorable progress.

  17. Melanoma maligno em búfalos (Bubalus bubalis albinos

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    Maria Cecília Florisbal Damé

    2015-10-01

    Full Text Available Descrevem-se melanomas múltiplos em dois búfalos albinos da raça Murrah no Sul do Brasil. Macroscopicamente havia múltiplos tumores enegrecidos no músculo esquelético, pulmões, linfonodos, saco pericárdio, cápsula renal, mediastino e pleura. Microscopicamente foram observadas células epitelióides poliédricas dispostas em ninhos sólidos ou fascículos entrelaçados sustentadas por um estroma colagenoso fino e esparso. O citoplasma era eosinofílico e por vezes continham quantidades variáveis de pigmento de melanina. A taxa de mitose foi baixa. Na imuno-histoquímica houve imunomarcação positiva utilizando anticorpo anti-tirosinase, anti-Melan-A, anti-vimentina, anti-proteína S-100 e antineurofilamento. É possível que o polimorfismo relacionado com o gene da pigmentação em búfalos albinos tenha contribuído para o maior risco de desenvolvimento de melanomas, como foi sugerido em humanos.

  18. Fissuras labiopalatinas, ganho de peso e cirurgias: leite materno versus fórmulas lácteas

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    Marcos Roberto Tovani Palone

    2015-10-01

    Full Text Available As fissuras labiopalatinas são as anomalias craniofaciais mais comuns na espécie humana. Por sua vez, com o propósito de ganho de peso corporal necessário para realização das cirurgias reabilitadoras, uma alternativa rotineiramente utilizada para crianças com fissuras consiste no uso de fórmulas lácteas industrializadas, como um substituto do leite materno ou mesmo uma suplementação alimentar. Contudo, é imprescindível a conscientização das mães e demais cuidadores desse grupo de crianças sobre a importância do aleitamento materno e seus benefícios adicionais, os quais inclusive colocam em questionamento a necessidade e viabilidade da prescrição dessas fórmulas nos casos em que a amamentação natural é possível. Ademais, o tipo de alimentação, aleitamento natural ou artificial é de notória importância, com influência direta na composição da microbiota gastrintestinal e possibilidades de impactos sobre a imunomodulação destes indivíduos.

  19. Desempenho e avaliação econômica da alimentação de cordeiros confinados com dietas contendo diferentes relações volumoso: concentrado Performance and economic evaluation of the feeding of feedlot lambs with diets with different roughage: concentrate ratios

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    Sérgio Carvalho

    2007-10-01

    Full Text Available Este estudo objetivou avaliar o efeito do uso de diferentes relações volumoso:concentrado sobre o desempenho, as características de carcaça e o conteúdo gastrintestinal de cordeiros, bem como realizar uma avaliação econômica da alimentação de cordeiros confinados na fase de terminação. Foram utilizados 25 cordeiros, machos não-castrados, da raça Texel, desmamados com a idade média de 60 dias, e distribuídos aleatoriamente em cinco tratamentos, compostos por diferentes relações volumoso:concentrado, sendo: 30:70; 40:60; 50:50; 60:40 e 70:30, em base da matéria seca (MS. O volumoso utilizado foi o feno de Tifton-85 e o alimento concentrado era constituído por ração comercial, farelo de soja, calcário calcítico e fosfato bicálcico, em diferentes proporções. O período experimental teve duração de 80 dias, quando os animais foram abatidos. O aumento do teor de volumoso e a diminuição no teor de concentrado nas dietas promoveu redução linear (P£0,01 no ganho de peso diário e peso vivo ao abate. O consumo de matéria seca e a conversão alimentar foram influenciados de forma quadrática pelo aumento da relação volumoso:concentrado. Verificou-se redução linear (P£0,01 no peso de carcaça quente, rendimento de carcaça quente e nos pesos de quarto (perna, paleta, costilhar, pescoço e de vísceras verdes vazias, com o aumento do teor de volumoso e a diminuição no teor de concentrado nas dietas. Ocorreu crescimento linear nas proporções de vísceras verdes cheias (P£0,05 e de conteúdo gastrintestinal (P£0,01 com a elevação da proporção de volumoso e com a redução na proporção de concentrado nas dietas. A lucratividade em relação à venda dos cordeiros vivos não diferiu entre os tratamentos, apresentando um valor médio de R$ 57,00 por cordeiro. Houve redução linear (P£0,05 na lucratividade em relação à venda das carcaças dos cordeiros com o aumento da proporção de volumoso e com a diminui

  20. Parasitism level by helminths and weight gain of calves kept in organic and conventional grazing

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    Jenevaldo Barbosa da Silva

    2013-05-01

    Full Text Available Sustainable production is a principle in which we must meet the needs of the present without compromising the capacity of future generations. Despite the successful development of pesticides against endo and ectoparasites found in domestic ruminants, these parasites are still the major problem of the herbivore production system. The purpose of this study was to know the population of gastrintestinal parasites and their influence on weight gain of calves kept in organic and conventional grazing. Thus, organic and conventional calves were randomly selected in 2008 and 2009. The fecal egg count (FEC indentified the following genders of helminths: Haemonchus, Trichostrongylus, Oesophagostomum, Cooperia, Strongyloides, Trichuris and oocysts of Eimeria. There was no significant difference (p>0.05 between FEC in organic and conventional animals. Calves younger than 6 months showed significant higher infection (p<0.05 than calves between 7 and 12 months of age. The weight gain observed during the study was of 327g/day and 280g/day for conventional and organic systems animals, respectively. Consequently, the combination of sustainable practices of grazing associated with the selective application of anthelmintics may be a feasible alternative for nematode control in a conventional system and in transition to an organic one.