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Sample records for estonian medical products

  1. Symptoms of anxiety and depression in Estonian medical students with sleep problems.

    Science.gov (United States)

    Eller, Triin; Aluoja, Anu; Vasar, Veiko; Veldi, Marlit

    2006-01-01

    High emotional stress in medical students has been observed in many studies. Our aim in this article was to assess the prevalence of symptoms of anxiety and depression among Estonian medical students and to find relationships between sleep complaints and emotional symptoms. The study group consisted of 413 medical students, ages 19-33 years, at the University of Tartu. Each was asked to complete two questionnaires: the Emotional State Questionnaire (EST-Q), containing 28 questions, and the Questionnaire on Sleep and Daytime Habits, with 25 questions. The anxiety and depression subscales from the EST-Q were applied. From the study group, 21.9% students had symptoms of anxiety, and 30.6% had symptoms of depression. The frequency of anxiety and depressive symptoms was higher in females. In regression and multiple regression analysis, we determined which sleep problems were related to emotional symptoms. The associations were different for men and women. In women, anxiety remained significantly related to waking up because of nightmares and feeling tired in the morning; depressive symptoms were related to difficulties in getting to sleep at night, waking up because of nightmares and nocturnal eating habits, daytime sleepiness, and sleepiness during school lessons. In men, significant relations were clear only for depression: difficulties in falling asleep at night before an exam and subjective sleep quality. The study demonstrated that a high percentage of medical students had emotional symptoms. We found that some sleep problems indicated underlying symptoms of anxiety and depression. (c) 2006 Wiley-Liss, Inc.

  2. Omaeluloolisus eesti teatris: Merle Karusoo lavastustest. Life Narratives and Estonian Theatre: The Productions of Merle Karusoo

    Directory of Open Access Journals (Sweden)

    Piret Kruuspere

    2012-04-01

    Full Text Available Any consideration of Estonian theatre from the point of view of biographical theatre needs to include the work of playwright and director Merle Karusoo. Productions based on various life narratives (diaries, letters, biographical interviews form the core of her work that can be defined as biographical or memory theatre. Her work has also been viewed within the context of community theatre or political theatre; Karusoo has herself referred to her work as sociological theatre. Life narratives have functioned in Karusoo’s productions as the basis for restoring oppressed or denied collective discourses of memory. Her productions emerged within the framework of the more general process of restoration of historical heritage and the rehabilitation of collective memory at the end of the 1980s and the beginning of the 1990s. Life story can be viewed as the essence of Merle Karusoo’s theatre. The personal in the life story in the production activates the emotional memory of the audience; for older generations such theatre facilitates a legitimisation of remembering one’s life story in entirety, and for younger generations it functions as a vehicle of collective, historical and national memory. The current article outlines the main stages of Karusoo’s biographical theatre, highlights major productions of each stage and provides an overview of their reception. Karusoo’s theatre dates back to 1980s. Productions based on life stories of the generations born in 1950s and 1960s, Meie elulood (Our Biographies and Kui ruumid on täis ... (Full Rooms both in 1982, mediated fragments of life stories of 16 drama students, focusing on the processes of self-conception and -reflection of young persons. In the context of the Soviet regime that exerted firm ideological control over the private lives of its citizens, Karusoo’s productions struck an especially powerful and unusual chord. Karusoo’s biographical theatre has gathered momentum and assumed a more

  3. Estonian literature / Janika Kronberg

    Index Scriptorium Estoniae

    Kronberg, Janika, 1963-

    2003-01-01

    Sisu: Estonian literature - born on the margins of Europe ; Baltic German literature and its impact ; Seeking the contours of a 'truly' Estonian literature ; Literature and an independent Estonia ; Estonian literature in two cultural spheres ; The fifties and sixties ; Literature and congealed time ; A bold new Estonian literature

  4. Estonian white paper on energy

    International Nuclear Information System (INIS)

    Hamburg, Arvi

    1997-01-01

    Energy policy, environmental protection and economy form a triangle of tightly linked sectors, and any solution of some energy problem can be solved only in the light of all the above mentioned factors. There are several energy master plans for Estonia, the first of them dating back to the years of the Soviet Union and ending the list with the plan to cover the years up to 2000. By now the basic principles of the Estonian energy policy have been prepared and Estonian Energy Concept is being worked out. The main goal of Estonian energy policy is ensure an effective and environmentally benign energy supply for the country. It means safety in energy supply, effective production and supply together with sufficient environmental protection. Energy Council in the role of an advisory voluntary organization for inspection of the energy system and finding measures to improve its efficiency is established with parliament members included. The Estonian Energy Research Institute and the Oil--Shale Research Institute serve as a scientific advisory board for the government in energy policy. It's important to emphasise that privatisation is no panacea, solving all the problems, and therefore we are facing hard to move in the right direction, satisfying all the consumers of energy

  5. Valued Estonian Music CDs

    Index Scriptorium Estoniae

    2004-01-01

    2002. aastal välja antud eesti muusika heliplaatidest Artur Kapp "Symphonische Werke", Eduard Tubin "Symphonies No.9, No.10 and No.11", "Estonian Preludes", "Eesti heliloojad. Hortus Musicus", "Eesti Muusika Päevad", "Tallinn Saxophone Quartet. Estonian Contemporary Music", "Triskele. Kolga-Jaani vaimulikud rahvalaulud", "Helmekaala. Linnupuu Anne", "Modern Fox mängib Raimond Valgret",

  6. Swedish-Estonian energy forest research cooperation

    International Nuclear Information System (INIS)

    Ross, J.; Kirt, E.; Koppel, A.; Kull, K.; Noormets, A.; Roostalu, H.; Ross, V.; Ross, M.

    1996-01-01

    The Organization of Estonian energetic economy is aimed at cutting the usage of oil, gas and coal and increasing the local resources firewood, oil-shale and peat for fuel. The resources of low-valued firewood-brushwood, fallen deadwood etc. are available during the following 10-15 years, but in the future the cultivation of energy forest (willow) plantations will be actual. During the last 20 years the Swedish scientists have been extensively studying the willow forest selection, cultivation and use in energetics and waste water purification systems. A Swedish-Estonian energy forest research project was started in 1993 between the Swedish Agricultural University on one hand and Toravere Observatory, Institute of Zoology and Botany, Estonian Academy of Sciences and Estonian Potato Processing Association on the other hand. In spring 5 willow plantations were established with the help of Swedish colleagues and obtained from Sweden 36000 willow cuttings. The aim of the project: a) To study experimentally and by means of mathematical modelling the biogeophysical aspects of growth and productivity of willow plantations in Sweden and Estonian climatological conditions. b) To study the possibility of using the willow plantations in waste waters purification. c) To study the economical efficiency of energy forest as an energy resource under the economic and environmental conditions of Estonia. d) To study the economic efficiency of willow plantations as a raw material for the basket industry in Estonia. e) To select the most productive and least vulnerable willow clones for practical application in energy plantations. During 1993 in all five plantations detailed analysis of soil properties has been carried out. In the plantation at Toravere Observatory phytometrical measurements were carried out - the growth of plant biomass leaf and stem area, vertical distribution of dry matter content, biomass and phyto area separately for leaves and stems has been performed. Some

  7. Estonian Folklore Archives

    Directory of Open Access Journals (Sweden)

    Risto Järv

    2013-10-01

    Full Text Available This essay presents the history and development of the The Estonian Folklore Archives, the central folklore archives of Estonia established in 1927, and examines its function in relation to the development of online databases. The Archives’ primary purpose has been to make the manuscript materials easily available for researchers working with the collection. The collections consist of manuscripts, sound recordings, photographs, and film and video materials, with an experimental multimedia collection as of 2008. The most extensive project related to the collections was the digitization in 2011-12 of Jakob Hurt’s folklore collection, stored in Kivike, a new file repository and archival infosystem of the Estonian Literary Museum.

  8. Estonian Jumal ‘God’

    OpenAIRE

    Karl Pajusalu; Renate Pajusalu; Ilona Tragel; Ann Veismann

    2016-01-01

    The article focuses on semantics and the use of the word jumal ‘god’ in Estonian. At first, we give an overview of the etymology of jumal ‘god’ and its meanings in Standard Estonian and Estonian dialects. Then we examine jumal ‘god’ as a linguistic unit associated with different constructions and collocational patterns, bleaching of the meaning, and usage in fulfilling different communication goals. In our study we show how jumal ‘god’ can refer literally to the higher power of Christianity o...

  9. Estonian Airi uued soodsad pakkumised

    Index Scriptorium Estoniae

    2010-01-01

    Estonian Airi kodulehelt on võimalik osta lennupileteid koostööpartnerite poolt pakutavatele mandritevahelistele lendudele ning broneerida internetis hotellituba Euroopa suurima hotelli broneerimise teenust pakkuva ettevõtte Booking.com kaudu

  10. [Mati Erelt. Estonian Language] / Katrin Hiietamm

    Index Scriptorium Estoniae

    Hiietamm, Katrin

    2004-01-01

    Arvustus: Estonian language / [Estonian Academy of Sciences] ; edited by Mati Erelt.Tallinn : Teaduste Akadeemia Kirjastus, 2003. 412, [1] lk. : ill., kaart. (Linguistica Uralica. Supplementary series, 0868-4731 ; vol. 1)

  11. History of medical radionuclide production.

    Science.gov (United States)

    Ice, R D

    1995-11-01

    Radionuclide production for medical use originally was incidental to isotope discoveries by physicists and chemists. Once the available radionuclides were identified they were evaluated for potential medical use. Hevesy first used 32P in 1935 to study phosphorous metabolism in rats. Since that time, the development of cyclotrons, linear accelerators, and nuclear reactors have produced hundreds of radionuclides for potential medical use. The history of medical radionuclide production represents an evolutionary, interdisciplinary development of applied nuclear technology. Today the technology is represented by a mature industry and provides medical benefits to millions of patients annually.

  12. [On ambient experience medical products].

    Science.gov (United States)

    Su, Jun

    2010-05-01

    Through the analysis on ambient experience medical products from Philips corporation, the article discusses the development trend of medical products, management strategy and design thinking as focusing on advantage industry, focusing on user experience, system integration of resources and opening and diverse design thinking.

  13. Cyclotron Production of Medical Radioisotopes

    Science.gov (United States)

    Ávila-Rodríguez, M. A.; Zárate-Morales, A.; Flores-Moreno, A.

    2010-08-01

    The cyclotron production of radioisotopes for medical applications is gaining increased significance in diagnostic molecular imaging techniques such as PET and SPECT. In this regard, radioisotope production has never been easier or more convenient until de introduction of compact medical cyclotrons in the last few decades, which allowed the use of short-lived radioisotopes in in vivo nuclear medicine studies on a routine basis. This review outlines some general considerations about the production of radioisotopes using charged particle accelerators.

  14. Overview of the Estonian Biofuels Association activities

    International Nuclear Information System (INIS)

    Hueues, Meelis

    2000-01-01

    Due to global warming and environment pollution because of widespread use of fossil fuels there are already tendencies to stabilize and decrease the consumption of these energy resources and take into use more renewable energy resources. Estonian Biofuels Association (EBA) is a non-profit association, which was founded on 8. of May 1998 in Tallinn. The EBA is an independent and voluntary alliance of its members. Fields of activity of the EBA are by biofuels research, developing and evaluation to engage environmental, biofuels and energy saving. EBA members are: energy consultants, scientists, as well as fuel suppliers, DH-companies, technology suppliers, energy service companies etc. The members of EBA are involved in different projects in Estonia, where biomass are produced and used for heating, where wood, waste, peat, rape oil and biogas resources are examined and put into use, and also projects which deal with energy saving and environment friendly equipment production for using biofuels. During our short experience we have noticed that people in Estonia have become more aware of biomass and their use, so the development of environment friendly and sustainable energetics will continue in Estonia. Available biofuels in Estonia could compete with fossil fuels if burnt rationally with high technology equipment. EBA members are convinced that biomass have perspective and that they could play an important role in improving Estonian economic and environmental situation. Modem biomass combustion devices are taken into use more the faster general wealth increases and EBA can raise people's awareness of bio fuel subject through special, courses and media. We want Estonian energy policy to develop towards widespread use of renewable energy resources, which would save energy and environment improve nation's foreign trade balance and create jobs mainly in rural areas

  15. Linacs for Medical Isotope Production

    Directory of Open Access Journals (Sweden)

    A. Pramudita

    2011-04-01

    Full Text Available This paper reviews efforts on using high energy (25-30 MeV and high power (10-20 kW electron linacs and lower energy (7 MeV proton linacs for medical radioisotope production. Using high energy x-rays from the electron linacs, PET (Positron Emission Tomography radioisotopes are produced through photonuclear reactions such as 19F(γ,n18F, which also allow production of other PET radionuclides 11C, 13N, and 15O. Other mostly used medical radionuclides 99mTc can also be obtained by using the electron linacs, through photofission or photonuclear reactions. Proton linacs for PET have also been recently developed and the product has been available in the market since 2005. The linacs have been tested for 18F production. As a proton accelerator, the target systems and nuclear reactions are similar to the ones used in PET cyclotrons

  16. Medical ice slurry production device

    Science.gov (United States)

    Kasza, Kenneth E [Palos Park, IL; Oras, John [Des Plaines, IL; Son, HyunJin [Naperville, IL

    2008-06-24

    The present invention relates to an apparatus for producing sterile ice slurries for medical cooling applications. The apparatus is capable of producing highly loaded slurries suitable for delivery to targeted internal organs of a patient, such as the brain, heart, lungs, stomach, kidneys, pancreas, and others, through medical size diameter tubing. The ice slurry production apparatus includes a slurry production reservoir adapted to contain a volume of a saline solution. A flexible membrane crystallization surface is provided within the slurry production reservoir. The crystallization surface is chilled to a temperature below a freezing point of the saline solution within the reservoir such that ice particles form on the crystallization surface. A deflector in the form of a reciprocating member is provided for periodically distorting the crystallization surface and dislodging the ice particles which form on the crystallization surface. Using reservoir mixing the slurry is conditioned for easy pumping directly out of the production reservoir via medical tubing or delivery through other means such as squeeze bottles, squeeze bags, hypodermic syringes, manual hand delivery, and the like.

  17. BEST medical radioisotope production cyclotrons

    Science.gov (United States)

    Sabaiduc, Vasile; Milton, Bruce; Suthanthiran, Krishnan; Gelbart, W. Z.; Johnson, Richard R.

    2013-04-01

    Best Cyclotron Systems Inc (BCSI) is currently developing 14 MeV, 25 MeV, 35MeV and 70MeV cyclotrons for radioisotope production and research applications as well as the entire spectrum of targets and nuclear synthesis modules for the production of Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and radiation therapy isotopes. The company is a subsidiary of Best Medical International, renowned in the field of medical instrumentation and radiation therapy. All cyclotrons have external negative hydrogen ion sources, four radial sectors with two dees in opposite valleys, cryogenic vacuum system and simultaneous beam extraction on opposite lines. The beam intensity ranges from 400 μA to 1000 μA, depending on the cyclotron energy and application [1].

  18. BEST medical radioisotope production cyclotrons

    Energy Technology Data Exchange (ETDEWEB)

    Sabaiduc, Vasile; Milton, Bruce; Suthanthiran, Krishnan; Johnson, Richard R. [Best Cyclotron Systems Inc., 7-8765 Ash Street, Vancouver, British Columbia, V6P 6T3 (Canada); Gelbart, W. Z. [Advanced System Designs Inc., 5295 Bear Bay Road, Garden Bay, BC, V0N 1S1 (Canada)

    2013-04-19

    Best Cyclotron Systems Inc (BCSI) is currently developing 14 MeV, 25 MeV, 35MeV and 70MeV cyclotrons for radioisotope production and research applications as well as the entire spectrum of targets and nuclear synthesis modules for the production of Positron Emission Tomography (PET), Single Photon Emission Computed Tomography (SPECT) and radiation therapy isotopes. The company is a subsidiary of Best Medical International, renowned in the field of medical instrumentation and radiation therapy. All cyclotrons have external negative hydrogen ion sources, four radial sectors with two dees in opposite valleys, cryogenic vacuum system and simultaneous beam extraction on opposite lines. The beam intensity ranges from 400 {mu}A to 1000 {mu}A, depending on the cyclotron energy and application.

  19. Energy potential of the Estonian rivers

    International Nuclear Information System (INIS)

    Reihan, Alvina; Kovalenko, Olga

    2002-01-01

    In the current study the river runoff, its long-term distribution and river slope were considered as factors in the evaluation of the hydro energy potential of the Estonian rivers. The analyses of the long-term runoff hydrographs showed the increase of the maximum discharges and the decrease of the minimum discharges, at the same time mean annual discharges were almost unchanged. It indicated that seasonal variability of the runoff decreased. The evaluation of the hydro energy potential of rivers showed, that the Narva and Paernu rivers are the most suitable for hydro energy production, then in decreasing order - the Kasari, Pedja, Piusa, Halliste, Vohandu, Jaegala rivers etc. The analyses of the Rannapungerja river runoff showed, that the activity of the restored Tudulinna hydropower plant had an influence on runoff in 2001: the minimum discharge was less than permitted by the legislative acts. Thus, the environmental aspects should have a high priority in hydropower plants reconstruction(author)

  20. Critical Success Factors and information needs in Estonian industry

    Directory of Open Access Journals (Sweden)

    Aiki Tibar

    2002-01-01

    Full Text Available The article reports the results of the study on the critical success factors and related information needs in Estonian industry conducted in 1999. Data were collected by interviews with 27 managers and engineers from 16 manufacturing companies in various industries. Most of the critical success factors taken up were related to marketing, information management, quality management, product development and technological innovations. The information needs of managers and engineers were related to competitors, customers, markets, technology, regulations, etc. Some identified CSFs expressed also priorities for development by Estonian economic authorities: to support the implementation of new technologies and introduction of quality management methods. The finding that information management was perceived as a very critical area supports the result of the recent Finnish study on CSFs.

  1. Efficiency of Estonian grain farms in 2000 2004

    Directory of Open Access Journals (Sweden)

    N. VASILIEV

    2008-12-01

    Full Text Available The aim of this study is to analyse the efficiency of Estonian grain farms after Estonia’s transition to a market economy and during the accession period to the European Union (EU. The non-parametric method Data Envelopment Analysis (DEA was used to estimate the total technical, pure technical and scale efficiency of Estonian grain farms in 2000–2004. Mean total technical efficiency varied from 0.70 to 0.78. Of the grain farms 62% are operating under increasing returns to scale. Solely based on the DEA model it is not possible to determine optimum farm scale and the range of Estonian farm sizes operating efficiently is extensive. The most pure technically efficient farms were the smallest and the largest but the productivity of small farms is low compared to larger farms because of their small scale. Therefore, they are the least competitive. Since pre-accession period to the EU, large input slacks of capital have replaced the former excessive use of labour and land. This raises the question about the effects on efficiency of the EU’s investment support schemes in new member states.;

  2. Estonian Air to overhaul strategy / Matt Withers

    Index Scriptorium Estoniae

    Withers, Matt

    2008-01-01

    Estonian Air on majanduslikes raskustes, mida aitaks leevendada riigipoolne toetus. Majandus- ja kommunikatsiooniminister Juhan Parts leiab, et riik peaks omama lennufirma juhatuses esimehe kohta, et mõjutada rohkem vastuvõetavaid otsuseid ja investeeringuid

  3. Estonian Golf & Country Club / Urmas Oja

    Index Scriptorium Estoniae

    Oja, Urmas, 1981-2012

    2005-01-01

    Konkursil "Eesti parim puitehitis 2005" pälvis voodrilaua eripreemia Jõelähtme Estonian Golf & Country Club'i katus. Arhitekt Andres Siim. Sisearhitekt Juta Lember. Konstruktor: AS Resand. 11 värv. ill

  4. On the System of Person-Denoting Signs in Estonian Sign Language: Estonian Name Signs

    Science.gov (United States)

    Paales, Liina

    2010-01-01

    This article discusses Estonian personal name signs. According to study there are four personal name sign categories in Estonian Sign Language: (1) arbitrary name signs; (2) descriptive name signs; (3) initialized-descriptive name signs; (4) loan/borrowed name signs. Mostly there are represented descriptive and borrowed personal name signs among…

  5. Air Baltic: Estonian Air on nurka surutud / Teele Tammeorg

    Index Scriptorium Estoniae

    Tammeorg, Teele

    2010-01-01

    Air Balticu asepresidendi Janis Vanagsi hinnangul on Estonian Air aastaid jätnud tähelepanuta oma peamised turismiturud ning on praegu halvas seisus. Air Baltic on endiselt huvitatud Estonian Airi ostust. Majandus- ja kommunikatsiooniminister Juhan Partsi seisukoht

  6. Composition of Estonian atmosphere

    International Nuclear Information System (INIS)

    Punning, J. M.; Karindi, A.

    1996-01-01

    Atmospheric study, particularly that of its chemical composition, has a long tradition in Estonia. Since middle of this century, in addition to meteorological observations, some chemical compounds in precipitations have been regularly measured in many meteorological stations. The main aim was to acquire information about the state and dynamics of the atmosphere. Therefore, main attention was paid to monitoring chemical compounds which have a direct impact on the human environment. As energy production developed intensively and SO 2 and NO x increased drastically in the atmosphere in acidic rock areas, like Scandinavia, the problem of acid rain became the most important environmental problem in Europe and North-America. As a consequence, monitoring the compounds of sulphur in precipitation was organized in Estonia. In the 1970 s, as related to large operating oil shale-based power plants, Estonia became a country , where emissions of sulphur compounds per capita were extremely high. In 1979, Estonia became a participant in the European Monitoring and Evaluation Programme - the network created to study transboundary air pollution. The aims of the precipitation chemistry study and the related problems of the formation and transformation of the atmospheric composition have varied over the years. But monitoring of pollutant (in particular, sulphur compound) loads has been a central issue. Over recent years, an attempt was made to estimate the spatial regularities of atmospheric impurities and their impact on the pH of mean monthly precipitations. Furthermore, calculations were provided to find out the origin of atmospheric impurities washed out in Estonia. Until the 1990 s, CO 2 , and some other greenhouse gas (GHG) emissions were not studied in Estonia. The first inventory of GHG for Estonia was provided in 1995 using the Intergovernmental Panel on Climate Change (IPCC) methodology

  7. Stocks of organic carbon in Estonian soils

    Directory of Open Access Journals (Sweden)

    Kõlli, Raimo

    2009-06-01

    Full Text Available The soil organic carbon (SOC stocks (Mg ha–1 ofautomorphic mineral (9 soil groups, hydromorphic mineral (7, and lowland organic soils (4 are given for the soil cover or solum layer as a whole and also for its epipedon (topsoil layer. The SOC stocks for forest, arable lands, and grasslands and for the entire Estonian soil cover were calculated on the basis of the mean SOC stock and distribution area of the respective soil type. In the Estonian soil cover (42 400 km2, a total of 593.8 ± 36.9 Tg of SOC is retained, with 64.9% (385.3 ± 27.5 Tg in the epipedon layer (O, H, and A horizons and 35.1% in the subsoil (B and E horizons. The pedo-ecological regularities of SOC retention in soils are analysed against the background of the Estonian soil ordination net.

  8. Digimodernistlik eesti kirjanik / The Digimodernist Estonian Writer

    Directory of Open Access Journals (Sweden)

    Piret Viires

    2013-06-01

    Full Text Available The article examines the cultural situation following postmodernism in the first decade of the 21st century. To characterise this situation, the umbrella term “post-postmodernism” is used, as well as “neomodernism”, “altermodern”, “metamodernism”, “hypermodernity”, “performatism”, “critical realism” etc. All these approaches are, in a wider sense, united by their aim of opposing postmodernist cynicism and irony, and bringing back truth, simplicity and clarity. It has also been found that literature has returned or is returning to realism, and various cultural phenomena are emerging, which have been designated by the concept “new sincerity”.In descriptions of the current cultural situation, this trend seeking truth and simplicity is supported by approaches which emphasise the significance of technological developments during the last decade. A prominent figure here is Alan Kirby, who launched the term “digimodernism”, mainly linked with the adaptation and spread of Web 2.0 at the beginning of the 21st century: the blogosphere, Wikipedia, Twitter and Facebook.The article seeks answers to the question of whether we can talk about digimodernism in Estonian literature in the 2000s. In the 1990s Estonian writers were quite reluctant to undertake computer-technological experiments, and there are only a few examples of Estonian digital literature, whereas a change occurred in the 2000s. Many Estonian writers have had and still have their own blogs and surprisingly many have joined Facebook. The term “twitterature” is also familiar to Estonian writers. The article tackles the dominant topics in the blogs of Estonian writers and analyses their possible collective creative work on Facebook. A question is raised as to whether it is possible that the fragmentary narrative structure of blogs and Facebook has influenced mainstream literature.The article concludes that one essential change in Estonian literature in the

  9. Sterility assurance of medical products

    International Nuclear Information System (INIS)

    Dierksheide, W.C.

    1977-01-01

    The present methods of regulating medical devices under the Food, Drug and Cosmetic Act in the United States of America are outlined. Reference is made to the position of drugs sterilized by irradiation. Surgical sutures and surgical dressings are regulated as drugs. Some details are given of proposed changes in the Act. The subject is further discussed under the headings: sterility assurance, and biocompatibility. (U.K.)

  10. Radiosterilization of medical products, pharmaceuticals and bioproducts

    International Nuclear Information System (INIS)

    1967-01-01

    A Panel on the Radiosterilization of Medical Products, Pharmaceuticals and Bioproducts was convened by the International Atomic Energy Agency on 17-19 January 1966 at its headquarters in Vienna. The purpose of the meeting was to survey the activities of the Member States in this field with a view to preparing the way for an international code of practice for the radiosterilization of medical products, in conformity with existing legal international rules. Refs, figs and tabs

  11. ACTUAL PROBLEMS OF MEDICAL GAS OXYGEN PRODUCTION

    OpenAIRE

    Подгорный, И. П.

    2014-01-01

    Medical gas oxygen is one of the most popular medicines. Its production is the major branch of the pharmaceutical industry. Provision of its high quality in the process of obtaining is an actual problem for companies of cryogenic oxygen production. For this purpose a concrete enterprise necessary to implement a quality assurance system in the production of medicinal products (QAS). The main component of the QAS is good manufacturing practice (Good Manufacturing Practice, GMP). It is shown how...

  12. Production of Medical Isotopes with Electron Linacs

    Energy Technology Data Exchange (ETDEWEB)

    Rotsch, D A; Alford, K.; Bailey, J. L.; Bowers, D. L.; Brossard, T.; Brown, M. A.; Chemerisov, S. D.; Ehst, D.; Greene, J.; Gromov, R. G.; Grudzinski, J.J.; Hafenrichter, L.; Hebden, A. S.; Henning, W.; Heltemes, T. A.; Jerden, J.; Jonah, C. D.; Kalensky, M.; Krebs, J. F.; Makarashvili, V.; Micklich, B.; Nolen, J.; Quigley, K. J.; Schneider, J. F.; Smith, N. A.; Stepinski, D. C.; Sun, Z.; Tkac, P.; Vandegrift, G. F.; Virgo, M J; Wesolowski, K. A.; Youker, A. J.

    2017-06-01

    Radioisotopes play important roles in numerous areas ranging from medical treatments to national security and basic research. Radionuclide production technology for medical applications has been pursued since the early 1900s both commercially and in nuclear science centers. Many medical isotopes are now in routine production and are used in day-to-day medical procedures. Despite these advancements, research is accelerating around the world to improve the existing production methodologies as well as to develop novel radionuclides for new medical appli-cations. Electron linear accelerators (linacs) represent a unique method for the production of radioisotopes. Even though the basic technology has been around for decades, only recently have electron linacs capable of producing photons with sufficient energy and flux for radioisotope production become available. Housed in Argonne Nation-al Laboratory’s Low Energy Accelerator Facility (LEAF) is a newly upgraded 55 MeV/25-kW electron linear ac-celerator, capable of producing a wide range of radioiso-topes. This talk will focus on the work being performed for the production of the medical isotopes 99Mo (99Mo/99mTc generator), 67Cu, and 47Sc.

  13. Valued Estonian Music CDs / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2003-01-01

    2002. aastal välja antud eesti muusika heliplaatidest Arvo Pärt "Summa", Lepo Sumera "Chamber Music", "Baltic Voices 1.", "Sequenzen - Europäische Orgelmusik des 20. Jahrhundrets mit...", "El silenco ئ Silence. Kuldar and Marje Sink. Songs of Mother and Son", "Riho Sibul. Estonian Dream Big Band", "Rull's Royce ئ Rull's Choice"

  14. English in the Estonian Multicultural Society.

    Science.gov (United States)

    Fonzari, Lorena

    1999-01-01

    Argues that the spread of English is not closely associated to a discourse of linguistic imperialism, basing the thesis on a case study in Estonia. Surveys of three generations of Estonians indicated that all welcomed English as a means of communications and technology in the modern world, reacting against the imposition of Russian language and…

  15. Resource and utilization of Estonian hydropower

    International Nuclear Information System (INIS)

    Raesaar, P.

    2005-01-01

    An overview of the Estonian hydropower resources and their utilization at present as well as prospective for the future are presented in this paper. A short overview of advantages of small hydropower stations and related issues is given. Some technological aspects are treated briefly. (authors)

  16. Transformational Leadership in the Estonian Defence Forces

    Directory of Open Access Journals (Sweden)

    Antek Kasemaa

    2015-06-01

    Full Text Available Purpose – The study is a contribution to the validation of the 15 items and 5 subscales Transformational Leadership Scale (TLS proposed by Rafferty and Griffin (2004. Design/methodology/approach – The sample includes participants from different levels of the Estonian Defence Forces (EDF military hierarchy (N=2570. The structure of the TLS was examined by using exploratory and confirmatory factor analyses. Additionally ANOVA was used to compare the results between different subsamples. Findings – TLS showed satisfactory reliability. Confirmatory factor analyses found TLS as valid five dimensions instrument to measure transformational leadership in the Estonian military context. Different management levels showed different emphases among the dimensions of transformational leadership. Research and practical limitations/implications – TLS will be an important tool to use in transformational leadership research in the Estonian military context and beyond. Additionally, the current research contributes to the development of alternative measurement tools besides the most commonly used MLQ. The limitation of the work will be the rather homogenous sample from the Estonian military, however it will open the door for the subsequent research using different samplings. Originality/value – The current research found TLS to be a reliable and valid instrument, very short and therefore easy to administrate, having the possibility to use it with five dimensional and as one general transformational instrument as well.

  17. Acquisition of noun derivation in Estonian and Russian L1

    Directory of Open Access Journals (Sweden)

    Reili Argus

    2018-04-01

    Full Text Available Acquisition of derivation is not a well-studied area in first language research and a comparative approach to the acquisition of derivation in different languages doesn’t exist. There is no information on how a child acquires derivation in a language with a rich and regular system of derivational patterns, or in a language where derivation is productive, but the system of derivational patterns is opaque. According to general ideas of complexity in a language, the child should start to use simplex stems first and, only after that, complex ones, that is, complexity should increase in the course of acquisition. Our paper is intended to address these issues, based on longitudinal child data from typologically different languages, Estonian and Russian. The results revealed significant differences in the acquisition of noun derivation in the two languages under observation. The system of noun derivation is acquired at a faster pace in Russian, while Estonian children have far fewer noun derivatives in their speech and they use different derivation suffixes with less regularity. Even so, the so-called building block model may be applied for both languages only partially.

  18. Strontium-89 production with medical isotope production reactor

    International Nuclear Information System (INIS)

    Deng Qimin; Li Maoliang; Cheng Zuoyong

    2007-01-01

    Medical isotope production reactor (MIPR) is a new type reactor for isotope production, it's an aqueous homogeneous solution reactor which can use High Enriched Uranium (HEU) or Low Enriched Uranium (LEU) as fuel. 89 Sr is bone seeking radiopharmaceuticals used for palliation of bone pain from osseous metastases. The current status of 89 Sr production, the structure and characteristics of MIPR as well as the principle of 89 Sr production whith MIPR are described here. (authors)

  19. External factors and the interference of L1 Estonian on L2 English pronunciation: An apparent-time study

    OpenAIRE

    Kristiina Ader; Merilin Miljan

    2015-01-01

    This study focusses on external factors of second language learning (L2) and their effect on L2 sound production. The aim was to find out whether young adults whose first language (L1) is Estonian speak L2 English with less accent than older speakers of L1 Estonian. Prior studies have claimed that more exposure to the target language lessens the effect of L1 interference (internal factors) (e.g. Piske et al. 2001, Muñoz, Llanes 2014). An apparent-time study was imple- mented in order to test ...

  20. The Challenges Organic Food Processors Meet at Small Emerging Market – Estonian Case

    OpenAIRE

    Sarapuu, Kerttu; Pehme, Sirli; Peetsmann, Elen; Matt, Darja

    2014-01-01

    Organic farming and demand for organic products is continually a growing trend all over the world (Willer et al., 2013). In Estonia the share of organic land is 15% of all agricultural land and the number of organic farmers is also growing (Vetemaa, Mikk 2013). Estonian organic food market is still in forming stage being affected by local organic farming development, marketing situation, economic situation and consumer attitudes. Organic processing has clearly not kept up with organic farming...

  1. Medical Radioisotopes Production Without A Nuclear Reactor

    Energy Technology Data Exchange (ETDEWEB)

    Van der Keur, H.

    2010-05-15

    This report is answering the key question: Is it possible to ban the use of research reactors for the production of medical radioisotopes? Chapter 2 offers a summarized overview on the history of nuclear medicine. Chapter 3 gives an overview of the basic principles and understandings of nuclear medicine. The production of radioisotopes and its use in radiopharmaceuticals as a tracer for imaging particular parts of the inside of the human body (diagnosis) or as an agent in radiotherapy. Chapter 4 lists the use of popular medical radioisotopes used in nuclear imaging techniques and radiotherapy. Chapter 5 analyses reactor-based radioisotopes that can be produced by particle accelerators on commercial scale, other alternatives and the advantages of the cyclotron. Chapter 6 gives an overview of recent developments and prospects in worldwide radioisotopes production. Chapter 7 presents discussion, conclusions and recommendations, and is answering the abovementioned key question of this report: Is it possible to ban the use of a nuclear reactor for the production of radiopharmaceuticals? Is a safe and secure production of radioisotopes possible?.

  2. NONWOVEN TEXTILES WITH MEDICAL DESTINATION ROMANIAN PRODUCTION

    Directory of Open Access Journals (Sweden)

    BULACU Romulus

    2015-05-01

    Full Text Available The widest range of medical disposable from nonwoven textiles are: absorbent and hygiene products : (diapers, feminine care, incontinence from the layered structures absorbent or impervious; use products such as hospital operating theaters sterile clothing (caps, gowns, masks, shoe coverings, materials for field operators, lab coats, packaging materials for hot or cold treatments, sterile materials (wipes, bandages, sterile bandages, etc.. Currently these materials, in their majority, are imported. This paper presents research done for getting, with the country equipment, disposable medical products from 40 g/m2 nonwoven textile materials. The technology adopted for the purpose, in SC "Minet" S.A. Ramnicu Valcea, Romania consisted of the following steps:Carding - folding, the aggregate Spinnbau-Hergeth type, Germany, with major changes carding technology adjustment and folding, to obtain a fibrous layer with a mass per unit surface of about 40-50 g / m2 and a width of 2,1 m;Pre-heat consolidation by pre-heating required only to ensure product stability required minimal interphase transport to final consolidation. Final thermal consolidation of the fibrous layer by thermal calendering at a temperature of 110°C and calenders cylinder speed of 2 m / min. The processing of the fiber by carding - folding and preliminary thermally consolidation and final by calendering.

  3. Early vocabulary in full term and preterm Estonian children.

    Science.gov (United States)

    Schults, Astra; Tulviste, Tiia; Haan, Elis

    2013-09-01

    Preterm birth is considered to be a high risk factor for child development and early vocabulary can be used as an indicator for later development. The aim of the present study is to compare the size of early vocabulary, proportional use of different word categories, and mean length of utterance (henceforth MLU) of preterm and full term children. The sample consisted of 40 preterm (corrected ages 16-25 months) and two matched groups of full term children. First full term group consisted of 120 children who were matched by age and gender. Second full term group consisted of 109 children who were matched by age, gender and size of productive vocabulary. The data for this study were gathered using the Estonian adaptation of MacArthur-Bates Communicative Development Inventory: Words and Sentences. Full term children who were matched by age and gender had larger vocabulary as compared to the preterm children's vocabulary (U = 1758.5, p = 0.01). Poisson regression yielded that age, gender, and preterm birth explained significantly the variance in the vocabulary size. Poisson regressions showed that all three variables explained significantly variance in proportional use of social terms and predicates. Age had significant effect for proportional use of common nouns. Age and preterm birth had a significant effect on the proportional use of function words. MLU was shorter in preterm than in full term children (U = 1125.0, p = 0.002). Estonian preterm children's vocabulary is slightly smaller than full term children's vocabulary. There is a difference in the proportions of word categories used, as preterm children use more social terms, and less predicates, and function words. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Accelerator Production of Isotopes for Medical Use

    Science.gov (United States)

    Lapi, Suzanne

    2014-03-01

    The increase in use of radioisotopes for medical imaging and therapy has led to the development of novel routes of isotope production. For example, the production and purification of longer-lived position emitting radiometals has been explored to allow for nuclear imaging agents based on peptides, antibodies and nanoparticles. These isotopes (64Cu, 89Zr, 86Y) are typically produced via irradiation of solid targets on smaller medical cyclotrons at dedicated facilities. Recently, isotope harvesting from heavy ion accelerator facilities has also been suggested. The Facility for Rare Isotope Beams (FRIB) will be a new national user facility for nuclear science to be completed in 2020. Radioisotopes could be produced by dedicated runs by primary users or may be collected synergistically from the water in cooling-loops for the primary beam dump that cycle the water at flow rates in excess of hundreds of gallons per minute. A liquid water target system for harvesting radioisotopes at the National Superconducting Cyclotron Laboratory (NSCL) was designed and constructed as the initial step in proof-of-principle experiments to harvest useful radioisotopes in this manner. This talk will provide an overview of isotope production using both dedicated machines and harvesting from larger accelerators typically used for nuclear physics. Funding from Department of Energy under DESC0007352 and DESC0006862.

  5. Production of molybdenum-99 for medical use

    International Nuclear Information System (INIS)

    Pervez, S.; Khan, Q.; Mirza, J.A.; Hussain, S.; Asif, M.; Khan, M.M.; Khalidand, U.; Siddique, M.U.

    2012-01-01

    Production of Molybdenum-99 (/sup 99/Mo) was carried out by irradiating 3 HEU targets in the core of Pakistan Research Reactor-1 (PARR-1) for 12 hours. The average radiochemical separation yield from various batches was 60-70%. Radionuclidic purity of final product was determined by gamma, alpha and beta spectrometry, while radiochemical purity was determined by paper chromatography. The produced /sup 99/Mo met all the criteria fixed in various pharmacopoeias. Pakgen /sup 99m/Tc generators were manufactured by indigenous /sup 99/Mo and sent to various medical centers for clinical trials. All the users were quite satisfied with the performance of Pakgen /sup 99m/Tc generators. (orig./A.B.)

  6. Utilisation of Estonian energy wood resources

    Energy Technology Data Exchange (ETDEWEB)

    Muiste, P.; Tullus, H.; Uri, V. [Estonian Agricultural University, Tartu (Estonia)

    1996-12-31

    In the end of the Soviet period in the 1980s, a long-term energy programme for Estonia was worked out. The energy system was planned to be based on nuclear power and the share of domestic alternative sources of energy was low. The situation has greatly changed after the re-establishment of the Estonian independence, and now wood and peat fuels play an important role in the energy system. Energy consumption in Estonia decreased during the period 1970-1993, but this process has less influenced the consumption of domestic renewable fuels - peat and wood. It means that the share of these fuels has grown. The investment on substitution of imported fossil fuels and on conversion of boiler plants from fossil fuels to domestic fuels has reached the level of USD 100 million. The perspectives of the wood energy depend mainly on two factors; the resources and the price of wood energy compared with other fuels. The situation in wood market influences both the possible quantities and the price. It is typical that the quickly growing cost of labour power in Estonia is greatly affecting the price of energy wood. Though the price level of fuel peat and wood chips is lower than the world market price today, the conditions for using biofuels could be more favourable, if higher environmental fees were introduced. In conjunction with increasing utilisation of biofuels it is important to evaluate possible emissions or removal of greenhouse gases from Estonian forests 3 refs.

  7. MINORITY LANGUAGES IN ESTONIAN SEGREGATIVE LANGUAGE ENVIRONMENTS

    Directory of Open Access Journals (Sweden)

    Elvira Küün

    2011-01-01

    Full Text Available The goal of this project in Estonia was to determine what languages are spoken by students from the 2nd to the 5th year of basic school at their homes in Tallinn, the capital of Estonia. At the same time, this problem was also studied in other segregated regions of Estonia: Kohtla-Järve and Maardu. According to the database of the population census from the year 2000 (Estonian Statistics Executive Office's census 2000, there are representatives of 142 ethnic groups living in Estonia, speaking a total of 109 native languages. At the same time, the database doesn’t state which languages are spoken at homes. The material presented in this article belongs to the research topic “Home Language of Basic School Students in Tallinn” from years 2007–2008, specifically financed and ordered by the Estonian Ministry of Education and Research (grant No. ETF 7065 in the framework of an international study called “Multilingual Project”. It was determined what language is dominating in everyday use, what are the factors for choosing the language for communication, what are the preferred languages and language skills. This study reflects the actual trends of the language situation in these cities.

  8. Estonian greenhouse gas emissions inventory report

    Energy Technology Data Exchange (ETDEWEB)

    Punning, J.M.; Ilomets, M.; Karindi, A.; Mandre, M.; Reisner, V. [Inst. of Ecology, Tallinn (Estonia); Martins, A.; Pesur, A. [Inst. of Energy Research, Tallinn (Estonia); Roostalu, H.; Tullus, H. [Estonian Agricultural Univ., Tartu (Estonia)

    1996-07-01

    It is widely accepted that the increase of greenhouse gas concentrations in the atmosphere due to human activities would result in warming of the Earth`s surface. To examine this effect and better understand how the GHG increase in the atmosphere might change the climate in the future, how ecosystems and societies in different regions of the World should adapt to these changes, what must policymakers do for the mitigation of that effect, the worldwide project within the Framework Convention on Climate Change was generated by the initiative of United Nations. Estonia is one of more than 150 countries, which signed the Framework Convention on Climate Change at the United Nations Conference on Environment and Development held in Rio de Janeiro in June 1992. In 1994 a new project, Estonian Country Study was initiated within the US Country Studies Program. The project will help to compile the GHG inventory for Estonia, find contemporary trends to investigate the impact of climate change on the Estonian ecosystems and economy and to formulate national strategies for Estonia addressing to global climate change.

  9. Utilisation of Estonian energy wood resources

    International Nuclear Information System (INIS)

    Muiste, P.; Tullus, H.; Uri, V.

    1996-01-01

    In the end of the Soviet period in the 1980s, a long-term energy programme for Estonia was worked out. The energy system was planned to be based on nuclear power and the share of domestic alternative sources of energy was low. The situation has greatly changed after the re-establishment of the Estonian independence, and now wood and peat fuels play an important role in the energy system. Energy consumption in Estonia decreased during the period 1970-1993, but this process has less influenced the consumption of domestic renewable fuels - peat and wood. It means that the share of these fuels has grown. The investment on substitution of imported fossil fuels and on conversion of boiler plants from fossil fuels to domestic fuels has reached the level of USD 100 million. The perspectives of the wood energy depend mainly on two factors; the resources and the price of wood energy compared with other fuels. The situation in wood market influences both the possible quantities and the price. It is typical that the quickly growing cost of labour power in Estonia is greatly affecting the price of energy wood. Though the price level of fuel peat and wood chips is lower than the world market price today, the conditions for using biofuels could be more favourable, if higher environmental fees were introduced. In conjunction with increasing utilisation of biofuels it is important to evaluate possible emissions or removal of greenhouse gases from Estonian forests 3 refs

  10. External factors and the interference of L1 Estonian on L2 English pronunciation: An apparent-time study

    Directory of Open Access Journals (Sweden)

    Kristiina Ader

    2015-04-01

    Full Text Available This study focusses on external factors of second language learning (L2 and their effect on L2 sound production. The aim was to find out whether young adults whose first language (L1 is Estonian speak L2 English with less accent than older speakers of L1 Estonian. Prior studies have claimed that more exposure to the target language lessens the effect of L1 interference (internal factors (e.g. Piske et al. 2001, Muñoz, Llanes 2014. An apparent-time study was imple- mented in order to test whether a change in learner setting (i.e. limited exposure to the target language vs. abundant exposure shows any evidence which can be explained by such external factors. Data was elicited from the speech samples of 97 speakers of L1 Estonian and L1 interference effects were analysed sound by sound. The results show that the younger generation displays less L1 Estonian interference than the older generation. Both greater exposure to the target language and earlier age of L2 learning onset correlate with the ability to produce more sounds target-like.

  11. Estonian Vodkat tuleb toota Eesti rukkist / Andres Reimer

    Index Scriptorium Estoniae

    Reimer, Andres

    2010-01-01

    Piiritusjookide määrusega Eesti geograafiliseks tähiseks saanud Estonian Vodka nimetusega viinad peaksid olema tehtud kodumaisest toorainest ning viinavabrikute ja piiritusetehase üle võiks toimuda kvaliteedikontroll

  12. Studies on the radiosterilization of medical products

    International Nuclear Information System (INIS)

    Lee, K.S.; Min, B.H.; Chun, K.J.; Kim, K.S.

    1979-01-01

    Most of the microorganisms isolated from the medical products were inactivated by the irradiation of 1.0-1.5 Mrad. However, some microorganisms were inactivated as the factor of 10 8 cells by the irradiation of 2.0-2.3 Mrad. Micrococcus roseus was a radioresistant strain, and on the view point of 10 8 cell number the dose for inactivating the Micrococcus roseus in a liquid and lyophilized condition was 2.3 and 3.5 Mrad, respectively. It has been found that the radiosensitivity of microorganism was influenced differently according to the suspended solution, oxygen, temperature and others. Radiosterlization of vaccine could not be performed due to the degeneration of vaccine. Cotton products were suitable where as disposable plastic set such as PVC product was not much suitable due to the reduction of pH or formation of oxidasable matter. Antibiotics in dry state was suitable where as dextrose solution or saline solution was unsuitable packing sheets (P.E, P.P, PVC) were suitable up to 2.5 Mrad dose. There was no relationships between cell growth rate and dose level in toxicity experiment of the irradiated plastic sets. Micrococcus roseus and Escherichia coli were effectively inactivated by treating heat pre-, post- or simultaneous irradiation. (author)

  13. Sustainable development and Estonian energetics

    International Nuclear Information System (INIS)

    Lausmaa, T.

    1997-01-01

    This conference was held 14 Nov 1997 in Tallinn, Estonia. The conference stressed the importance of the diminishing the negative impact of energy production on the environment. The Government and the Parliament should ensure the composing of short and long term master plans with the public participation for all sectors of the economy, based on the principles of sustainable development, the involved international treaties and the Sustainable Development Framework Act

  14. Radioisotope Production for Medical and Physics Applications

    Science.gov (United States)

    Mausner, Leonard

    2012-10-01

    Radioisotopes are critical to the science and technology base of the US. Discoveries and applications made as a result of the availability of radioisotopes span widely from medicine, biology, physics, chemistry and homeland security. The clinical use of radioisotopes for medical diagnosis is the largest sector of use, with about 16 million procedures a year in the US. The use of ^99Mo/^99mTc generator and ^18F make up the majority, but ^201Tl, ^123I, ^111In, and ^67Ga are also used routinely to perform imaging of organ function. Application of radioisotopes for therapy is dominated by use of ^131I for thyroid malignancies, ^90Y for some solid tumors, and ^89Sr for bone cancer, but production of several more exotic species such as ^225Ac and ^211At are of significant current research interest. In physics ^225Ra is of interest for CP violation studies, and the actinides ^242Am, ^249Bk, and ^254Es are needed as targets for experiments to create superheavy elements. Large amounts of ^252Cf are needed as a fission source for the CARIBU experiment at ANL. The process of radioisotope production is multidisciplinary. Nuclear physics input based on nuclear reaction excitation function data is needed to choose an optimum target/projectile in order to maximize desired isotope production and minimize unwanted byproducts. Mechanical engineering is needed to address issues of target heating, induced mechanical stress and material compatibility of target and claddings. Radiochemists are involved as well since chemical separation to purify the desired final radioisotope product from the bulk target and impurities is also usually necessary. Most neutron rich species are produced at a few government and university reactors. Other radioisotopes are produced in cyclotrons in the commercial sector, university/hospital based facilities, and larger devices at the DOE labs. The landscape of US facilities, the techniques involved, and current supply challenges will be reviewed.

  15. Production of medical radioisotopes with linear accelerators.

    Science.gov (United States)

    Starovoitova, Valeriia N; Tchelidze, Lali; Wells, Douglas P

    2014-02-01

    In this study, we discuss producing radioisotopes using linear electron accelerators and address production and separation issues of photoneutron (γ,n) and photoproton (γ,p) reactions. While (γ,n) reactions typically result in greater yields, separating product nuclides from the target is challenging since the chemical properties of both are the same. Yields of (γ,p) reactions are typically lower than (γ,n) ones, however they have the advantage that target and product nuclides belong to different chemical species so their separation is often not such an intricate problem. In this paper we consider two examples, (100)Mo(γ,n)(99)Mo and (68)Zn(γ,p)(67)Cu, of photonuclear reactions. Monte-Carlo simulations of the yields are benchmarked with experimental data obtained at the Idaho Accelerator Center using a 44MeV linear electron accelerator. We propose using a kinematic recoil method for photoneutron production. This technique requires (100)Mo target material to be in the form of nanoparticles coated with a catcher material. During irradiation, (99)Mo atoms recoil and get trapped in the coating layer. After irradiation, the coating is dissolved and (99)Mo is collected. At the same time, (100)Mo nanoparticles can be reused. For the photoproduction method, (67)Cu can be separated from the target nuclides, (68)Zn, using standard exchange chromatography methods. Monte-Carlo simulations were performed and the (99)Mo activity was predicted to be about 7MBq/(g(⁎)kW(⁎)h) while (67)Cu activity was predicted to be about 1MBq/(g(⁎)kW(⁎)h). Experimental data confirm the predicted activity for both cases which proves that photonuclear reactions can be used to produce radioisotopes. Lists of medical isotopes which might be obtained using photonuclear reactions have been compiled and are included as well. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Production of Thallium 201 for medical applications

    International Nuclear Information System (INIS)

    Braghirolli, A.M.S.

    1981-12-01

    With the purpose of producing high purity carrier-free 201 Tl, for medical use, a production and separation method was developed using the CV-28 Cyclotron of the Nuclear Engineering Institute in Rio de Janeiro, Brazil. 201 Pb was produced by 24 MeV proton bombardment of natural Tl and allowed to decay to 201 Tl. In the separation process the target is dissolved in HNO 3 , the 201 Pb produced is separated by Fe(OH) 3 coprecipitation, and the Fe is latter separated by anion exchange. The 201 Pb is permited to decay during 32 hrs. 201 Tl is then separated from remaining Pb by anion exchange. The chemical separation is done in a remote processing cell using manipulators, tongs, electric and pneumatic systems. The thick target yield of 201 Pb is 1.7 mCi/μAhr. At the moment the production is restricted to 4 mCi of 201 Tl for each irradiation. (Author) [pt

  17. Estonian Airi Boeing sattus kaks korda hädaolukorda / Krister Kivi

    Index Scriptorium Estoniae

    Kivi, Krister, 1975-

    2011-01-01

    Estonian Airi Boeing ES-ABL sattus 2011. aasta algus kahel korral ohtlikku olukorda. Lennuamet tegi Estonian Airile ettekirjutuse, kuid seda pole ameti kodulehel avaldatud. Lennufirma kapteni ja lennuohutuse inspektori Andreas Kari, lennuameti selgitusi

  18. Estonian Air valmistub odavate piletitega EasyJeti tulekuks / Erkki Erilaid

    Index Scriptorium Estoniae

    Erilaid, Erkki

    2004-01-01

    Estonian Air pidi langetama piletihindu Berliini ja Londoni liinil kolmandiku võrra, kuna oktoobri lõpust hakkab Tallinna lennujaamast reise tegema uus odavlennufirma Easy-Jet. Lisa: Estonian Airi hinnad internetis

  19. Joakim Helenius: Estonian Air võtku eeskuju airBalticust / Siim Sultson

    Index Scriptorium Estoniae

    Sultson, Siim

    2010-01-01

    Estonian Airi ühe võimaliku nõukogu esimehe Jaokim Heleniuse hinnangul on väikeste lennufirmade, nagu Estonian Air ja airBaltic jaoks päris palju tegutsemisruumi. Estonian Airil tuleb leida oma nišš ja kindel, kuid omanäoline strateegia

  20. Adapting the Survey of Attitudes towards Statistics (SATS-36) for Estonian Secondary School Students

    Science.gov (United States)

    Hommik, Carita; Luik, Piret

    2017-01-01

    The purpose of this study is to adapt the Survey of Attitudes Towards Statistics (SATS-36) for Estonian secondary school students in order to develop a valid instrument to measure students' attitudes within the Estonian educational context. The SATS-36 was administered to Estonian-speaking secondary school students before their compulsory…

  1. Radioisotope production with a medical cyclotron

    International Nuclear Information System (INIS)

    Silvester, D.J.

    1974-01-01

    The cyclotron of Hammersmith hospital in England was completed and started the operation in 1955. The feature is in its design operable at high beam current, reaching 500μA in internal beam and 300μA in external beam. In 1960's, twelve nuclides of radioactive pharmaceuticals were produced with the cyclotron. C-11, N-13 and O-15 have been used in the form of radioactive gases such as CO or H 2 O to test lung functions. F-18 has been used for bone scanning. K-43 is employed in the research of electrolyte balancing together with Na-24 and Br-77. Fe-52 is utilized in iron ion researches as a tracer. Cs-129 is highly evaluated as an isotope for imaging cardiac clogging part. Radioisotopes must be much more used in the examination of in vivo metabolic function. For this purpose, peculiarly labelled compounds should be further developed. It is welcome that the persons paying attention to the medical prospect of cyclotrons are increasing. The author hopes to continue his endeavour to find new products made with the cyclotron for human welfare. (Wakatsuki, Y.)

  2. Chernobyl is still haunting us. Radionuclides in Estonian mushrooms

    International Nuclear Information System (INIS)

    Martin, J.; Vilde, R.; Martin, L.; Aaspollu, J.; Tekko, S.

    1993-01-01

    The disaster that happened at the Chernobyl nuclear power station in 1986 caused a sharp rise in radioactive pollution over an extensive area in the region of the Baltic Sea. To estimate the distribution and the concentration of Cs-137 and Sr-90 in Estonian ecosystems, samples of mushrooms, mosses, lichens and the upper horizons of soil were gathered from 63 test sites during 1991. We were particularly interested in the amounts of radionuclides in mushrooms because these are used as food by people. Dangerously high radionuclide concentrations were found in mushrooms gathered in North-East Estonia. Heightened concentrations were registered here and there all over the territory of Estonia, especially in mushrooms gathered in Central and South-Western Estonia. The Cs-137 content in mushrooms depends on its content in other components of the ecosystems, first and foremost on the concentrations of radiocaesium in mosses and litter, which, therefore, can be used as indicators in prognostication the radioactive pollution of mushrooms in a certain region. As Cs-137 migrates between various ecosystem components, it is necessary to check the radioactivity of the forest products used for food for still a number of years to come. The Sr-90 level was low in all the ecosystem components examined. (author). 3 figs., 10 refs

  3. Estonian Airi president : uus äristrateegia toob ettevõttele edu / Borge Thornbech ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Thornbech, Borge

    2007-01-01

    Estonian Air asutas regionaalsete lendude korraldamiseks ettevõtte Estonian Air Regional, idee on arendada tegevust lühidistantsidel ja luua ühenduslüli lennukompanii Euroopa-liinide vahel. Kommenteerivad Olev Schults, Oleg Harlamov, Rein Mark. Vt. samas: Kõik aktsionärid vannuvad Estonian Airile truudust; Estonian Air kaalub Tartu lennuliini avamist. Kaart: Reisijate jagunemine sihtkohtade vahel. Graafikud: Estonian Air kukkus kahjumisse

  4. [Medical equipment product lines in basic pharmacies].

    Science.gov (United States)

    Macesková, B; Lipská, J

    2003-07-01

    Medical appliances dispensed in basic type pharmacies for cash or vouchers for medical or orthopedic appliances require expertise of pharmacists and laboratory assistants concerning the assortment, payment, construction of prices, conditions for prescription, ordering, properties, and functions of individual appliances. Using the method of frequency analysis, the analysis of data from five pharmacies within a period of three months (more than 17,000 records) revealed how individual subgroups of medical appliances and their concrete items are represented in both types of dispensation. The method of the semistructured questionnaire (10 respondents) was used to find what problems are encountered in dispensation, and which medical appliances and their subgroups are the sources of the problems. The respondents regard the contemporary level of knowledge concerning medical appliances gained in pregradual studies as insufficient.

  5. The production of medical audiovisual teaching materials--Chinese style.

    Science.gov (United States)

    Wu, Z C

    1994-07-01

    The production of medical audiovisual material for the advancement of medical education in China is a problem requiring an urgent solution. To achieve faster, better and more economical results, the production of audiovisual material must be undertaken with careful planning and efficient management. A systematic approach is essential to control production. The procedures described are: leadership and management; choice of subject and medium; production; distribution and evaluation.

  6. An epidemiological perspective of personalized medicine: the Estonian experience.

    Science.gov (United States)

    Milani, L; Leitsalu, L; Metspalu, A

    2015-02-01

    The Estonian Biobank and several other biobanks established over a decade ago are now starting to yield valuable longitudinal follow-up data for large numbers of individuals. These samples have been used in hundreds of different genome-wide association studies, resulting in the identification of reliable disease-associated variants. The focus of genomic research has started to shift from identifying genetic and nongenetic risk factors associated with common complex diseases to understanding the underlying mechanisms of the diseases and suggesting novel targets for therapy. However, translation of findings from genomic research into medical practice is still lagging, mainly due to insufficient evidence of clinical validity and utility. In this review, we examine the different elements required for the implementation of personalized medicine based on genomic information. First, biobanks and genome centres are required and have been established for the high-throughput genomic screening of large numbers of samples. Secondly, the combination of susceptibility alleles into polygenic risk scores has improved risk prediction of cardiovascular disease, breast cancer and several other diseases. Finally, national health information systems are being developed internationally, to combine data from electronic medical records from different sources, and also to gradually incorporate genomic information. We focus on the experience in Estonia, one of several countries with national goals towards more personalized health care based on genomic information, where the unique combination of elements required to accomplish this goal are already in place. © 2014 The Authors. Journal of Internal Medicine published by John Wiley & Sons Ltd on behalf of The Association for the Publication of the Journal of Internal Medicine.

  7. Estonian electricity supply scenarios for 2020 and their environmental performance

    Energy Technology Data Exchange (ETDEWEB)

    Koskela, Sirkka; Seppaelae, Jyri; Hiltunen, Marja-Riitta [Research Programme for Production and Consumption, Finnish Environment Institute, P.O. Box 140, 00251 Helsinki (Finland); Lipp, Ando; Pold, Evelin; Talve, Siret [CyclePlan Ltd, Akadeemia road 33, 12618 Tallinn (Estonia)

    2007-07-15

    Estonia is the only country in Europe with significant environmentally intensive oil shale-based energy production. However, the legal obligations of the EU will make substantial changes over the coming years to current electricity production technology. Increasing the use of alternative energy carriers for responding to future requirements has also been in focus. In this study, three different future electricity supply scenarios for Estonia in 2020 are considered and compared to the situation in 2002. They are based on domestic oil shale, imported natural gas, and imported nuclear power. According to the aims of the national energy policy, renewable energy sources were raised to 10% in all scenarios. Using the LCA methodology, the least damaging impact on the environment occurs in the 'nuclear scenario', with nuclear energy as the main energy source. The best scenario, however, depends on the weight or acceptance of accidental releases or other impacts not defined in this context. The 'Oil shale scenario' would be a slightly more damaging alternative than the 'Natural gas scenario' even if new technical solutions will remarkably improve the environmental performance of oil shale electricity production. Land use and waste disposal are crucial issues, particularly for oil shale and nuclear electricity production. However, the depletion of oil shale is not as critical an issue as the depletion of natural gas and uranium. According to the significance analysis of impact categories, climate change is the most significant impact on the environment in the scenarios. Future decisions on the development of the Estonian energy sector are most likely to be based on technological, economical and political aspects. Political aspects are likely to be the most significant. However, this type of study can give additional value to the discussion due to the increasing role of sustainability in energy issues. (author)

  8. The Role of Accountant in the Estonian Enterprise

    Directory of Open Access Journals (Sweden)

    Ergo Ottoson

    2016-06-01

    Full Text Available Recent developments and changes in the modern economy as well as falls and rises of large corporations have brought up the public interest towards the accounting discipline, and have resulted in a growing demand for accountant specialists as educated professionals. The aim of the present research is to find out what is the role of the accountant in the modern enterprise. The authors conducted a survey among Estonian accounting specialists and managers. The results of the survey clearly indicate that in most Estonian companies, accountants are actively assisting members of the board to make vital decisions, and their competence, knowledge and skills are highly valued by managers. The findings of the survey emphasize that Estonian accountants are highly qualified, keeping in line with the latest developments in the modern financial world.

  9. Ethnic Self-Esteem and Intergroup Attitudes Among the Estonian Majority and the non-Estonian Minority

    Directory of Open Access Journals (Sweden)

    Maaris Raudsepp

    2009-11-01

    Full Text Available The study was focussed on the relationships between ethnic self-esteem and various indicators of intergroup attitudes in a representative sample of adult population of Estonia (N=1142. Attitudinal variables that discriminated most between persons with high and low ethnic self-esteem were identified. Among Estonians ethnic self-esteem was related to positive ingroup bias, readiness for outgroup contact, perceived threat from the outgroup, attitudes to non-Estonian minority, and attitudes toward minority integration. Among non-Estonians ethnic self-esteem was related to readiness for outgroup contact, ethnic sterotypes, and various attitudes towards minority integration. An attempt was made to reconstruct the system of intergroup attidues of prototypical persons with high and low ethnic selfesteem and to describe psychological implications of high and low ethnic self-esteem for members of majority and minority groups. Various theoretical models (social identity theory, integrated threat theory, social dominane theory were used for interpretation of the results.

  10. Fuel preparation for use in the production of medical isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Policke, Timothy A.; Aase, Scott B.; Stagg, William R.

    2016-10-25

    The present invention relates generally to the field of medical isotope production by fission of uranium-235 and the fuel utilized therein (e.g., the production of suitable Low Enriched Uranium (LEU is uranium having 20 weight percent or less uranium-235) fuel for medical isotope production) and, in particular to a method for producing LEU fuel and a LEU fuel product that is suitable for use in the production of medical isotopes. In one embodiment, the LEU fuel of the present invention is designed to be utilized in an Aqueous Homogeneous Reactor (AHR) for the production of various medical isotopes including, but not limited to, molybdenum-99, cesium-137, iodine-131, strontium-89, xenon-133 and yttrium-90.

  11. Spatial patterns of soil organic carbon stocks in Estonian arable soils

    Science.gov (United States)

    Suuster, Elsa; Astover, Alar; Kõlli, Raimo; Roostalu, Hugo; Reintam, Endla; Penu, Priit

    2010-05-01

    Soil organic carbon (SOC) determines ecosystem functions, influencing soil fertility, soil physical, chemical and biological properties and crop productivity. Therefore the spatial pattern of SOC stocks and its appropriate management is important at various scales. Due to climate change and the contribution of carbon store in the soils, the national estimates of soil carbon stocks should be determined. Estonian soils have been well studied and mapped at a scale 1:10,000. Previous studies have estimated SOC stocks based on combinations of large groups of Estonian soils and the mean values of the soil profile database, but were not embedded into the geo-referenced databases. These studies have estimated SOC stocks of Estonian arable soils 122.3 Tg. Despite of available soil maps and databases, this information is still very poorly used for spatial soil modelling. The aim of current study is to assess and model spatial pattern of SOC stocks of arable soils on a pilot area Tartu County (area 3089 sq km). Estonian digital soil map and soil monitoring databases are providing a good opportunity to assess SOC stocks at various scales. The qualitative nature of the initial data from a soil map prohibits any straightforward use in modelling. Thus we have used several databases to construct models and linkages between soil properties that can be integrated into soil map. First step was to reorganize the soil map database (44,046 mapping units) so it can be used as an input to modelling. Arable areas were distinguished by a field layer of Agricultural Registers and Information Board, which provides precise information of current land use as it is the basis of paying CAP subsidies. The estimates of SOC content were found by using the arable land evaluation database of Tartu from the Estonian Land Board (comprising 950 sq km and 31,226 fields), where each soil type was assessed separately and average SOC content grouped by texture was derived. SOC content of epipedon varies in

  12. Radiation sterilization of medical products- current trends and future prospects

    International Nuclear Information System (INIS)

    Sharma, G.

    1997-01-01

    In medical practice use of sterile pharmaceuticals and single use disposable medical devices is steadily increasing. Sterile pharmaceuticals like injections and ophthalmic ointments are required for therapy. Medical devices are employed for diagnostic, drug administration or corrective purposes, and as implants for temporary, short term or long term residence in the human system. All these products are made available in sterile form by treating them to a suitable process of sterilization i.e. dry/wet heat, ethylene oxide (EtO) gas or ionizing radiation. In this paper current trends and future prospects of radiation sterilization of medical products are given in detail. 9 refs., 7 tabs

  13. Linking a population biobank with national health registries-the estonian experience.

    Science.gov (United States)

    Leitsalu, Liis; Alavere, Helene; Tammesoo, Mari-Liis; Leego, Erkki; Metspalu, Andres

    2015-04-16

    The Estonian population-based biobank, with 52,000 participants' genetic and health data, is the largest epidemiological cohort in the Baltic region. Participants were recruited through a network of medical professionals throughout Estonia (population 1.34 million). Unique legislation as well as a broad consent form give the Estonian Genome Center, a research institute of the University of Tartu, permission to re-contact participants and to retrieve participants' data from national registries and databases. In addition to two re-contacting projects to update the health data of participants, extensive clinical characterizations have been retrieved from national registries and hospital databases regularly since 2010. Acquiring data from electronic health records and registries has provided a means to update and enhance the database of the Genome Center in a timely manner and at low cost. The resulting database allows a wide spectrum of genomic and epidemiological research to be conducted with the aim of benefitting public health. Future plans include linking the genome center database with the national health information system through X-road and exchanging data in real time, as well as using the genetic data and the technical infrastructure available for piloting personalized medicine in Estonia.

  14. Linking a Population Biobank with National Health Registries—The Estonian Experience

    Science.gov (United States)

    Leitsalu, Liis; Alavere, Helene; Tammesoo, Mari-Liis; Leego, Erkki; Metspalu, Andres

    2015-01-01

    The Estonian population-based biobank, with 52,000 participants’ genetic and health data, is the largest epidemiological cohort in the Baltic region. Participants were recruited through a network of medical professionals throughout Estonia (population 1.34 million). Unique legislation as well as a broad consent form give the Estonian Genome Center, a research institute of the University of Tartu, permission to re-contact participants and to retrieve participants’ data from national registries and databases. In addition to two re-contacting projects to update the health data of participants, extensive clinical characterizations have been retrieved from national registries and hospital databases regularly since 2010. Acquiring data from electronic health records and registries has provided a means to update and enhance the database of the Genome Center in a timely manner and at low cost. The resulting database allows a wide spectrum of genomic and epidemiological research to be conducted with the aim of benefitting public health. Future plans include linking the genome center database with the national health information system through X-road and exchanging data in real time, as well as using the genetic data and the technical infrastructure available for piloting personalized medicine in Estonia. PMID:25894366

  15. Linking a Population Biobank with National Health Registries—The Estonian Experience

    Directory of Open Access Journals (Sweden)

    Liis Leitsalu

    2015-04-01

    Full Text Available The Estonian population-based biobank, with 52,000 participants’ genetic and health data, is the largest epidemiological cohort in the Baltic region. Participants were recruited through a network of medical professionals throughout Estonia (population 1.34 million. Unique legislation as well as a broad consent form give the Estonian Genome Center, a research institute of the University of Tartu, permission to re-contact participants and to retrieve participants’ data from national registries and databases. In addition to two re-contacting projects to update the health data of participants, extensive clinical characterizations have been retrieved from national registries and hospital databases regularly since 2010. Acquiring data from electronic health records and registries has provided a means to update and enhance the database of the Genome Center in a timely manner and at low cost. The resulting database allows a wide spectrum of genomic and epidemiological research to be conducted with the aim of benefitting public health. Future plans include linking the genome center database with the national health information system through X-road and exchanging data in real time, as well as using the genetic data and the technical infrastructure available for piloting personalized medicine in Estonia.

  16. Production of thallium 201 for medical use

    International Nuclear Information System (INIS)

    Venikov, N.I.; Konyakhin, N.A.; Kozlova, M.D.; Volkova, N.M.

    1986-01-01

    An important product among the radiopharmaceuticals currently used in cardiology is T1 201 chloride, due to its nuclear-physical properties and its clinical value as a diagnostic tool. The authors explain and discuss the basic characteristics which determine the radiopharmaceutical quality of T1 201: its radiochemical purity and its chemical impurity content, which depend on the target-irradiation conditions - type of nuclear reaction, target material and design, particle energy, irradiation time - and the reprocessing technology. A production flow chart is presented which shows that ions are accelerated within a wide mass and energy range suitable for the production of T1 201 in different nuclear reactions. Cyclotron reconstruction for T1 201 production is discussed

  17. Personal control of privacy and data: Estonian experience.

    Science.gov (United States)

    Priisalu, Jaan; Ottis, Rain

    2017-01-01

    The Republic of Estonia leads Europe in the provision of public digital services. The national communications and transactions platform allows for twenty-first century governance by allowing for transparency, e-safety (inter alia privacy), e-security, entrepreneurship and, among other things, rising levels of prosperity, and well-being for all its Citizens. However, a series of Information Infrastructure attacks against the Estonian e-society infrastructure in 2007 became one of best known incidents and experiences that fundamentally changed both Estonian and international discussions about Cyber Security and Privacy. Estonian experience shows that an open and transparent attitude provides a good foundation for trust between the Citizen and the State, and gives more control to the real owner of the data - the Citizen. Another important lesson is that the Citizen needs to be confident in the government's ability to keep their data safe -- in terms of confidentiality, integrity and availability - establishing a strong link between privacy and information security. This paper discusses certain critical choices, context, and events connected to the birth and growth of the Estonian e-society in terms of Privacy.

  18. Kas Bombardier lennutab Estonian Airi üles? / Henrik Ilves

    Index Scriptorium Estoniae

    Ilves, Henrik

    2011-01-01

    Estonian Air on saanud oma käsutusse kaks kolmest ostetud lennukist Bombardier CRJ900, millega saavutatakse Boeing 737-ga võrreldes oluline kütuse kokkuhoid. 20 aastaga on müüdud CRJ-seeria lennukeid juba üle 1700

  19. Estonian Golf & Country Club / Liina Jänes

    Index Scriptorium Estoniae

    Jänes, Liina, 1977-

    2005-01-01

    Estonian Golf & Country Club'i etnomodernistlik golfikeskus ja klubihoone Jõelähtmel. Projekteerija: Arhitektuuristuudio Siim & Kreis. Autor Andres Siim. Konstruktor: Resand. Sisekujundaja Juta Lember (SAB Lember & Padar). Projekt 2004, valmis 2005. Ill.: I ja II korruse plaan, 3 värv. välis ja 3 sisevaadet

  20. Estonian Golf & Country Clubi klubihoone / Andres Siim, Alar Just

    Index Scriptorium Estoniae

    Siim, Andres

    2005-01-01

    Harjumaal Jõelähtme vallas rajab Estonian Golf & Country Club uut Jägala-Jõesuu spordi- ja puhkekeskust, mille südameks saab puidust golgiklubi hoone, mida tutvustavad klubihoone arhitekt ja üks inseneridest. Ill.: vaade ehitusele, projekti kaks vaadet, lõige

  1. Top 10 Estonian albums of 2004 / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    2004-01-01

    Heliplaatidest: Arvo Pärt "Pro et contra", Various composers "Baltic Voices 2", Raimo Kangro "Displays", Toivo Tulev "Be Lost in the Call", Indrek Vau and Mati Mikalai "Estonian Trumpet Music", Erdmann/Sooäär "Dessert Time, Peer Gynt & Other Stories", Alo Mattiisen "50 parimat laulu", Riho Sibul "Must", Rein Rannap "Tantsib klaveril", Eesti Keeled "Kella tiksumist..."

  2. Organizational Commitment in Estonian University Libraries: A Review and Survey

    Science.gov (United States)

    Kont, Kate-Riin; Jantson, Signe

    2014-01-01

    The data used in this article is based on the reviewing of relevant literature to provide an overview of the concepts of organizational commitment, job security, and interpersonal relations, as well as on the results of the original online survey, conducted by the article's authors, held in 2012 in Estonian university libraries governed by public…

  3. Medications Containing Aspirin (Acetylsalicylate) and Aspirin-Like Products

    Science.gov (United States)

    updated 3/10/08 Medications Containing Aspirin (Acetylsalicylate) and Aspirin-Like Products © National Reye's Syndrome Foundation Inc. 2008 Epidemiologic research has shown an association between the development of Reye's ...

  4. Scientific production of medical sciences universities in north of iran.

    Science.gov (United States)

    Siamian, Hasan; Firooz, Mousa Yamin; Vahedi, Mohammad; Aligolbandi, Kobra

    2013-01-01

    NONE DECLARED. The study of the scientific evidence citation production by famous databases of the world is one of the important indicators to evaluate and rank the universities. The study at investigating the scientific production of Northern Iran Medical Sciences Universities in Scopus from 2005 through 2010. This survey used scientometrics technique. The samples under studies were the scientific products of four northern Iran Medical universities. Viewpoints quantity of the Scientific Products Mazandaran University of Medical Sciences stands first and of Babol University of Medical Sciences ranks the end, but from the viewpoints of quality of scientific products of considering the H-Index and the number of cited papers the Mazandaran University of Medical Sciences is a head from the other universities under study. From the viewpoints of subject of the papers, the highest scientific products belonged to the faculty of Pharmacy affiliated to Mazandaran University of Medial Sciences, but the three other universities for the genetics and biochemistry. Results showed that the Mazandaran University of Medical Sciences as compared to the other understudies universities ranks higher for the number of articles, cited articles, number of hard work authors and H-Index of Scopus database from 2005 through 2010.

  5. 75 FR 57045 - Parallel Review of Medical Products

    Science.gov (United States)

    2010-09-17

    ... decision making process for FDA-regulated medical products after they have been approved or cleared by FDA... slow the developer's quest for Medicare coverage. We believe that a parallel review process can furnish... envision that the decision to undertake the parallel review process with respect to a specific product will...

  6. CLUPEA HARENGUS MEMBRAS: ABOUT THE ETYMOLOGY OF A CERTAIN FISH NAME IN ESTONIAN, LATVIAN AND LIVONIAN

    Directory of Open Access Journals (Sweden)

    Udo Uibo

    2012-01-01

    Full Text Available In this article, the names of Clupea harengus membras will be considered in Estonian, (Salaca Livonian and Latvian (respectively räim, reńǵ and reņģe ‘Baltic herring’. It will be shown that the source of all of these words is the Estonian-Swedish strämg (sträηg, or its preceding word shape *sträimg. The Latvian reņģe is borrowed from Estonian-Swedish through Salaca Livonian. Paul Ariste proposed an adequate etymology for the Estonian räim as early as 1933.

  7. [Pärtel Lippus. The acoustic features and perception of the Estonian quantity system] / Stefan Werner

    Index Scriptorium Estoniae

    Werner, Stefan

    2012-01-01

    Arvustus: Pärtel Lippus. The acoustic features and perception of the Estonian quantity system. Tartu : Tartu University Press, 2011. (Dissertationes philologiae estonicae Universitatis Tartuensis ; 29)

  8. Production of 77 Br for medical application

    International Nuclear Information System (INIS)

    Bastos, M.A.V.

    1982-01-01

    Bromine-77 is produced with the variable energy cyclotron (CV-28) at the Instituto de Engenharia Nuclear, via the 75 As. (α, 2 n) 77 Br reaction, by bombarding arsenic trioxide with 28 MeV alpha-particles. The thick target yield is 0.3 mCi/μAh. The target is dissolved in concentrated N H 4 OH and 77 Br, separated from arsenic, by an anionic exchange resin, is obtained carrier-free with a separation yield greater than 90%. All the process is remotely controlled using electric and pneumatic systems, manipulators and tongs. The quality control is made by atomic absorption and gamma-ray spectroscopy. The present production rate of Br-77 is 2.3 mCi per irradiation. (author)

  9. Estonian Air püüdis viimase hetkeni Top Toursi päästa / Mirko Ojakivi

    Index Scriptorium Estoniae

    Ojakivi, Mirko

    2010-01-01

    Estonian Air kaalus Top Toursile appiminekut, sest reisifirma oli Estonian Airil üks olulisemaid koostööpartnereid. Abi oleks puudutanud ennekõike uutele lendudele allahindluse tegemist, räägiti ka võimalikust krediidist

  10. Production Situation and Technology Prospect of Medical Isotopes

    Directory of Open Access Journals (Sweden)

    GAO Feng;LIN Li;LIU Yu-hao;MA Xing-jun

    2016-10-01

    Full Text Available The isotope production technology was overviewed, including traditional and newest technology. The current situation of medical isotope production was introduced. The problems faced by isotope supply and demand were analyzed. The future development trend of medical isotopes and technology prospect were put forward. As the most populous country, nuclear medicine develops rapidly, however, domestic isotope mainly relies on imports. The highly productive and relatively safe MIPR is expected to be an effective way to breakthrough the bottleneck of the development of nuclear medicine. Traditional isotope production technologies with reactor can be improved. It's urgent to research and promote new isotope production technologies with reactor. Those technologies which do not depend on reactor will have a bright market prospects.

  11. Rupturing otherness: becoming Estonian in the context of contemporary Britain.

    Science.gov (United States)

    Märtsin, Mariann

    2010-03-01

    While identity construction continues to be a widely discussed and researched area in contemporary social sciences, the existing theories have overlooked the importance of understanding why and how identities as semiotic constructions emerge in individuals' consciousness in the flow of their everyday functioning. This article seeks to address this limitation in the theorizing by proposing an alternative conceptualization of identity, according to which identity construction is triggered by rupturing life-experience, which surfaces another perspective and makes the person aware of a possibility to be otherwise or of the reality of being different. Theoretical claims put forward in the paper are drawn from data gathered in a recent study, which explored lived-through experiences of young Estonians, who made study-visits to the United Kingdom. The discussed data will also highlight some interesting aspects in Estonians' self-definition as it is constructed in relation to Eastern-European identity in the context of contemporary Britain.

  12. Medical and biomedical research productivity from Palestine, 2002 – 2011

    Directory of Open Access Journals (Sweden)

    Sweileh Waleed M

    2013-02-01

    Full Text Available Abstract Background Medical research productivity reflects the level of medical education and practice in a particular country. The objective of this study was to examine the quantity and quality of medical and biomedical research published from Palestine. Findings Comprehensive review of the literature indexed by Scopus was conducted. Data from Jan 01, 2002 till December 31, 2011 was searched for authors affiliated with Palestine or Palestinian authority. Results were refined to limit the search to medical and biomedical subjects. The quality of publication was assessed using Journal Citation Report. The total number of publications was 2207. A total of 770 publications were in the medical and biomedical subject areas. The annual rate of publication was 0.077 articles per gross domestic product/capita. The 770 publications have an h-index of 32. One hundred and thirty eight (18% articles were published in 46 journals that were not indexed in the web of knowledge. Twenty two (22/770; 2.9% articles were published in journals with an IF > 10. Conclusions The quantity and quality of research originating from Palestinian institutions is promising given the scarce resources of Palestine. However, more effort is needed to bridge the gap in medical research productivity and to promote better health in Palestine.

  13. Testing the Visual Soil Assessment tool on Estonian farm fields

    Science.gov (United States)

    Reintam, Endla; Are, Mihkel; Selge, Are

    2017-04-01

    Soil quality estimation plays important role in decision making on farm as well on policy level. Sustaining the production ability and good health of the soil the chemical, physical and biological indicators should be taken into account. The system to use soil chemical parameters is usually quite well established in most European counties, including Estonia. However, measuring soil physical properties, such bulk density, porosity, penetration resistance, structural stability ect is time consuming, needs special tools and is highly weather dependent. In that reason these parameters are excluded from controllable quality parameters in policy in Estonia. Within the project "Interactive Soil Quality Assessment in Europe and China for Agricultural Productivity and Environmental Resilience" (iSQAPER) the visual soil assessment (VSA) tool was developed for easy detection of soil quality as well the different soil friendly agricultural management practices (AMP) were detected. The aim of current study was to test the VSA tool on Estonian farm fields under different management practices and compare the results with laboratory measurements. The main focus was set on soil physical parameters. Next to the VSA, the undisturbed soil samples were collected from the depth of 5-10 cm and 25-30 cm. The study revealed that results of a visually assessed soil physical parameters, such a soil structure, soil structural stability, soil porosity, presence of tillage pan, were confirmed by laboratory measurements in most cases. Soil water stable structure measurement on field (on 1 cm2 net in one 1 l box with 4-6 cm air dry clods for 5-10 min) underestimated very well structured soil on grassland and overestimated the structure aggregates stability of compacted soil. The slightly better soil quality was detected under no-tillage compared to ploughed soils. However, the ploughed soil got higher quality points compared with minimum tillage. The slurry application (organic manuring) had

  14. Estonian Leader's Freedom Call Creates Storm / Anna Smolchenko

    Index Scriptorium Estoniae

    Smolchenko, Anna

    2008-01-01

    President Toomas Hendrik Ilvese esinemisest soome-ugri rahvaste maailmakongressil Hantõ-Mansiiskis, kohtumisest Venemaa presidendi Dmitri Medvedeviga, Eesti delegatsiooni saalist väljamarssimisest Venemaa riigiduuma väliskomisjoni esimehe Konstantin Kossatshovi sõnavõtu ajal. Ilmunud ka: St. Petersburg Times 1. juuli 2008, pealk.: Estonian Leader's Freedom Call Creates Controversy (lüh.). Vabariigi President töövisiidil Venemaal 27.-30.06.2008

  15. Exhibition of photography from the Estonian diaspora / Ellu Maar

    Index Scriptorium Estoniae

    Maar, Ellu, 1982-

    2010-01-01

    Näitus "Photography from the Estonian Diaspora / Väliseesti foto" Kumu Kunstimuuseumis 8.10.-19.11.2010, kuraatorid Eha Komissarov ja Ellu Maar. Näitus tutvustas 1944. a. Eestist lahkunud või juba võõrsil sündinud fotograafide (Eric Soovere, Karl Hintzer, Priit Vesilind, Rein Välme jt.) loomingut ja valikut väliseesti fotoarhiividest

  16. The Role of Accountant in the Estonian Enterprise

    OpenAIRE

    Ergo Ottoson; Monika Nikitina-Kalamae; Natalja Gurvitš

    2016-01-01

    Recent developments and changes in the modern economy as well as falls and rises of large corporations have brought up the public interest towards the accounting discipline, and have resulted in a growing demand for accountant specialists as educated professionals. The aim of the present research is to find out what is the role of the accountant in the modern enterprise. The authors conducted a survey among Estonian accounting specialists and managers. The results of the survey clearly indica...

  17. Revisiting the Estonian Cyber Attacks: Digital Threats and Multinational Responses

    Directory of Open Access Journals (Sweden)

    Stephen Herzog

    2011-01-01

    Full Text Available In April 2007, the Estonian Government moved a memorial commemorating the Soviet liberation of the country from the Nazis to a less prominent and visible location in Tallinn. This decision triggered rioting among Russian-speaking minorities and cyber terrorism targeting Estonia's critical economic and political infrastructure. Drawing upon the Estonian cyber attacks, this article argues that globalization and the Internet have enabled transnational groups—such as the Russian diaspora—to avenge their grievances by threatening the sovereignty of nation-states in cyberspace. Sophisticated and virtually untraceable political "hacktivists" may now possess the ability to disrupt or destroy government operations, banking transactions, city power grids, and even military weapon systems. Fortunately, western countries banded together to effectively combat the Estonian cyber attacks and minimize their effects. However, this article concludes that in the age of globalization, interdependence, and digital interconnectedness, nation-states must engage in increased cooperative cyber-defense activities to counter and prevent devastating Internet attacks and their implications.

  18. Olev Schults : SAS vajab Estonian Airi rahvusliku lennufirmana / Olev Schults ; interv. Andres Reimer

    Index Scriptorium Estoniae

    Schults, Olev

    2008-01-01

    Estonian Airi nõukogu esimees vastab küsimustele, kas SAS arendas Läti airBalticut Estonian SAS-i arvel, mis mõte on rahvuslikul lennukompaniil, kui riik ei tohi seda finantseerida, kuidas mõjutab investorite meeleolu SAS-i Eestis tabanud poliitikute kriitika tulv

  19. Estonian Air jäi kolmest Fokkerist ilma / Toivo Tänavsuu

    Index Scriptorium Estoniae

    Tänavsuu, Toivo

    2006-01-01

    Estonian Airil ei õnnestunud saada kolme väiksemat reaktiivlennukit, lennuparki püütakse mitmekesistada järgmistel aastatel. Sel aastal loodetakse saada juurde ühe Boeing 737-300. Lisa: Boeing: Estonian Air on tasemel

  20. The Representation of the Cold War in Three Estonian History Textbooks

    Science.gov (United States)

    Korbits, Keit

    2015-01-01

    The article looks at the discursive strategies different Estonian history textbooks employ to represent the Cold War period, and the "commonsense" ideologies instilled through these representations. The textbooks analysed include two history books dating back to the Estonian Soviet Socialist Republic and, for contrast, one written during…

  1. Development of lowenergy accelerator-based production of medical isotopes

    OpenAIRE

    Radcliffe, Naomi; Barlow, Roger; Cywinski, Robert; Beasley, P.

    2013-01-01

    Here we present methods for production of new and existing isotopes for SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) imaging using accelerator-based systems. Such isotopes are already widely used in medical diagnostics and research, and there is constant development of new drugs and isotopes. However the main production method for 99mTc, is currently in research reactors and is at risk due to scheduled and unscheduled shut downs. Therefore, a low c...

  2. Medical-isotope supply hit by production problems

    Science.gov (United States)

    Gould, Paula

    2008-10-01

    A shortfall in the production of medical isotopes in Europe has forced hospitals to delay patient scans or offer alternative diagnostic tests. The problems began in August when all three nuclear reactors used to generate molybdenum-99, which then decays to form the key nuclear-imaging agent technetium-99, had to be unexpectedly shut down at the same time.

  3. Research Productivity of ]unior Academic Staff at a Tertiary Medical ...

    African Journals Online (AJOL)

    Research Productivity of ]unior Academic Staff at a Tertiary Medical College in South West, Nigeria. OA Lesi, OO Orenuga, A Roberts, OO Abudu. Abstract. No Abstract. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL.

  4. 75 FR 35493 - Guidance for Industry on Systemic Lupus Erythematosus-Developing Medical Products for Treatment...

    Science.gov (United States)

    2010-06-22

    ... ``Lupus Nephritis Caused by Systemic Lupus Erythematosus--Developing Medical Products for Treatment... entitled ``Systemic Lupus Erythematosus--Developing Medical Products for Treatment.'' This guidance... medical devices for the treatment of systemic lupus erythematosus (SLE). This guidance finalizes the draft...

  5. On organization of medical radionuclides production in Ukraine

    International Nuclear Information System (INIS)

    Zelens'kij, V.F.; Pilipenko, M.Yi.; Shulyika, M.G.; Skibyin, V.Yi.; Kostyin, V.Ya.; Vyikman, Ya.E.; Kalmikov, L.Z.; Nesterov, V.G.; Krasnoperova, A.P.

    1994-01-01

    Annual demand for radiopharmaceuticals in Ukraine is about 50.000 GBq and expenses for their purchase are about 1 - 2 mln US dollars per year. It determines expediency of their production in Ukraine. Taking into consideration the fact that one of the aftereffects of the accident at Chernobyl Atomic Power Station is inevitable increase of the number of oncological diseases (including malignant growths of the thyroid gland) the demand for radionuclides will be increasing steadily. Therefore, it is clear that organization of the centre for radiopharmaceuticals production will not solve the problem of providing radiological departments with them. One of the possible ways to solve the problem is creation of a network of regional centres for radioactive isotopes production. Realisation of the suggested program will allow to solve the problem of providing the medical establishments of Ukraine with medical radionuclides. Performed technical and economical evaluation shows that the expenses will be compensated in 2.9 years

  6. Law N° 29459 of pharmaceutical products, medical devices and sanitary products

    OpenAIRE

    Dongo, Victor; Médico, Director General de la Dirección General de Medicamentos, Insumos y Drogas, Ministerio de Salud. Lima, Perú.

    2009-01-01

    The Law of Pharmaceutical Products, Medical devices and Sanitary products N°. 29459, published in November, 2009, guides the regulations of these products, substituting Chapter III of the General Law of Health N°. 26842. Through this law, the most questioned aspects of the Law N°. 26842 have been modified, establishing requisites to apply for the sanitary registry of pharmaceutical products that are necessary to guarantee their efficacy, security and quality, also including the required t...

  7. Prospects for radiation sterilization of medical products in Egypt

    International Nuclear Information System (INIS)

    Roushdy, H.M.

    1975-01-01

    The pharmaceutical industry in Egypt is continually expanding its activity and each year marks new accomplishments and additions which enable the companies to apply the most modern scientific means in the production of pharmaceutical preparations and consequently to improve their market potentialities. The certainty of expansion and the possibility of increasing exports of sterilized medical products, particularly to Arab and African countries, indicate a need for a gamma-sterilization plant. This technology permits the introduction of the latest practices with regard to used disposables, thus greatly reducing the chances of cross-contamination which usually results in serious complications enhanced by local environmental conditions. This paper reviews the current state and future prospects for radiation sterilization of medical products and biological tissues in connection with other related industrial radiation processings. Moreover, the paper reviews the Egyptian scientific and technical experience with irradiation facilities and the parameters underlying the choice of Egypt's first industrial gamma and electron-beam irradiators designed for more than a single-purpose use, with hygienic measures taken to avoid biological contamination of sterilized medical packages throughout the sterilization process. In addition, the paper deals with the policy set up for establishing the Egyptian National Centre for Radiation Technology with a view to introducing irradiation techniques in the sterilization of medical products, and to improving the properties and increasing the competitiveness of Egyptian fabrics. Apart from medical sterilization, certain industrial processes have been mentioned to show how a multi-purpose irradiation facility may be utilized in a developing country to justify significantly the large investment required. (author)

  8. Radiation sterilization of medical products in the Philippines

    Science.gov (United States)

    Singson, C.; Carmona, C.; de Guzman, Z.; Barrun, W.; Lanuza, L.

    This paper presents the results of a comprehensive investigation of the biological, microbiological, physico-chemical, and dosimetry aspects of using gamma irradiation for the sterilization of locally manufactured medical products and pharmaceuticals. The objective of this study is to determine the technological feasibility of radiation sterilization for the said products in the Philippines. Hence, the materials used were directly obtained from local manufacturers. They are polyvinyl chloride or polyethylene based medical plastic disposables namely: absorbent cotton, surgical gauze, bandage, visceral packs, and some antibiotics and opthalmic ointments. The gamma facility of the Philippine Atomic Energy Commission was used for the irradiation. Result of biological studies indicate no signs of toxicity on experimental mice injected with extracts from irradiated samples. The contaminants are identified as Pseudomonas Sp. Staphyloccocus Aureus and Bacillus Subtilis. The D 10 values of survivors of higher doses ranged below 0.235 Megarad suggesting that these contaminants can be eliminated by the generally used sterilizing dose of 2.5 Mrads. The physico-chemical tests did not indicate any significant degradation of the irradiated products. Opthalmic and topical antibiotic ointments showed no marked decrease in potency. Fading tests on dosimeters used showed that red perspex is a more efficient dosimeter than clear perspex when irradiation time is prolonged. These studies indicated that radiation sterilization is technically feasible for locally manufactured medical products.

  9. Production of medical short-lived radionuclides in Canada

    International Nuclear Information System (INIS)

    Wiebe, L.I.

    1985-01-01

    The production of radionuclides for medical and biomedical research in Canada has been reviewed with respect to the national geographic and demographic characteristics which influence their use. The types of facilities available for the production of short-lived radionuclides have been summarized, and a tabulation of the radionuclides that are produced has been presented. In broad terms production facilities can be classified as belonging to one of two groups, nuclear reactor or charged-particle accelerators. The charged-particle accelerators produce the more neutron-deficient and (because of the resultant decay properties) the more useful radionuclides for medical application. The nuclear reactor facilities for radionuclide production range in size and capacity from the high-flux research reactors of AECL to the six SLOWPOKE reactors, five of which are located on university campuses across the country. The McMaster University reactor is used to produce curie quantities of fluorine-18 weekly. Millicurie amounts of a large number of radionuclides, most of which have half-lives ranging from 2 to 50 hr, are produced in the low-flux reactors, in support of basic medical research

  10. Electronic medical records and efficiency and productivity during office visits.

    Science.gov (United States)

    Furukawa, Michael F

    2011-04-01

    To estimate the relationship between electronic medical record (EMR) use and efficiency of utilization and provider productivity during visits to US office-based physicians. Cross-sectional analysis of the 2006-2007 National Ambulatory Medical Care Survey. The sample included 62,710 patient visits to 2625 physicians. EMR systems included demographics, clinical notes, prescription orders, and laboratory and imaging results. Efficiency was measured as utilization of examinations, laboratory tests, radiology procedures, health education, nonmedication treatments, and medications. Productivity was measured as total services provided per 20-minute period. Survey-weighted regressions estimated association of EMR use with services provided, visit intensity/duration, and productivity. Marginal effects were estimated by averaging across all visits and by major reason for visit. EMR use was associated with higher probability of any examination (7.7%, 95% confidence interval [CI] = 2.4%, 13.1%); any laboratory test (5.7%, 95% CI = 2.6%, 8.8%); any health education (4.9%, 95% CI = 0.2%, 9.6%); and fewer laboratory tests (-7.1%, 95% CI = -14.2%, -0.1%). During pre/post surgery visits, EMR use was associated with 7.3% (95% CI= -12.9%, -1.8%) fewer radiology procedures. EMR use was not associated with utilization of nonmedication treatments and medications, or visit duration. During routine visits for a chronic problem, EMR use was associated with 11.2% (95% CI = 5.7%, 16.8%) more diagnostic/screening services provided per 20-minute period. EMR use had a mixed association with efficiency and productivity during office visits. EMRs may improve provider productivity, especially during visits for a new problem and routine chronic care.

  11. Use of unmanned aerial vehicles for medical product transport.

    Science.gov (United States)

    Thiels, Cornelius A; Aho, Johnathon M; Zietlow, Scott P; Jenkins, Donald H

    2015-01-01

    Advances in technology and decreasing costs have led to an increased use of unmanned aerial vehicles (UAVs) by the military and civilian sectors. The use of UAVs in commerce is restricted by US Federal Aviation Administration (FAA) regulations, but the FAA is drafting new regulations that are expected to expand commercial applications. Currently, the transportation of medical goods in times of critical need is limited to wheeled motor vehicles and manned aircraft, options that can be costly and slow. This article explores the demand for, feasibility of, and risks associated with the use of UAVs to deliver medical products, including blood derivatives and pharmaceuticals, to hospitals, mass casualty scenes, and offshore vessels in times of critical demand. Copyright © 2015 Air Medical Journal Associates. Published by Elsevier Inc. All rights reserved.

  12. SCK-CEN increases production of medical isotopes by half

    International Nuclear Information System (INIS)

    Ponsard, B.; Leysen, P.; Janssens, J.

    2010-01-01

    It is impossible to imagine the medical world today without radioisotopes, and due to rapid technological progress in nuclear medicine their use is still on the rise. An important role of research reactors is the production of molybdenum-99. Around the world this is done primarily by five nuclear research reactors, one of which is the BR2 reactor of SCK-CEN. As a result of checks and maintenance work on three other reactors, for a few years there has been a serious crisis in the availability of this medical isotope. In order to guarantee the worldwide supply of radioisotopes, SCK-CEN expanded its production of molybdenum-99 by 50 percent in 2010.

  13. Medical Isotope Production Analyses In KIPT Neutron Source Facility

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, Alberto [Argonne National Lab. (ANL), Argonne, IL (United States); Gohar, Yousry [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-01-01

    Medical isotope production analyses in Kharkov Institute of Physics and Technology (KIPT) neutron source facility were performed to include the details of the irradiation cassette and the self-shielding effect. An updated detailed model of the facility was used for the analyses. The facility consists of an accelerator-driven system (ADS), which has a subcritical assembly using low-enriched uranium fuel elements with a beryllium-graphite reflector. The beryllium assemblies of the reflector have the same outer geometry as the fuel elements, which permits loading the subcritical assembly with different number of fuel elements without impacting the reflector performance. The subcritical assembly is driven by an external neutron source generated from the interaction of 100-kW electron beam with a tungsten target. The facility construction was completed at the end of 2015, and it is planned to start the operation during the year of 2016. It is the first ADS in the world, which has a coolant system for removing the generated fission power. Argonne National Laboratory has developed the design concept and performed extensive design analyses for the facility including its utilization for the production of different radioactive medical isotopes. 99Mo is the parent isotope of 99mTc, which is the most commonly used medical radioactive isotope. Detailed analyses were performed to define the optimal sample irradiation location and the generated activity, for several radioactive medical isotopes, as a function of the irradiation time.

  14. Premarket Regulation of Tissue Engineered Medical Products in China.

    Science.gov (United States)

    Wang, Chunren; Wang, Anqi; Feng, Xiaoming; Ke, Linnan; Huang, Yuanli; Han, Qianqian; Sun, Xue; Yang, Zhaopeng

    2015-12-01

    Tissue engineered medical products (TEMPs) use state-of-the-art technologies and offer the patients with alternative clinical options for diseases that conventional treatments may fail or be incompetent. However promising, this technology is comparatively new with very limited hands-on experiences with both manufacturing and clinical therapy. Of great significance to products with such complexity and novelty is the establishment of a complete jurisdiction framework and a standardization database so that the safety of the technique in clinical treatment can be ensured. Although different regulatory routes are adopted in different countries, risks are generally considered to be derived from the cellular components within the product, the material scaffolds, and potentially from the final products. This article is to provide an insight of the regulatory considerations and the role of China Food and Drug Administration (CFDA) in the supervision of TEMPs.

  15. Service Productivity and Complexity in Medical Rescue Services

    Directory of Open Access Journals (Sweden)

    Markus Harlacher

    2017-05-01

    Full Text Available The increasing impact of services on economic wealth and income in high wage countries calls for a detailed examination of service productivity and complexity in current research projects. This paper describes the development of a measurement model of service productivity and complexity within the domain of medical service provision. While the measurement model of service productivity is partly literature-based, a novel construct is developed for service complexity. The reliability and validity of these constructs have been analyzed by a survey with 454 employees of German medical rescue service providers. Reliability of the construct is estimated by analyzing Cronbach’s alpha, average variance extracted, variance inflation factors and the significance, weights and loadings of the items. Furthermore, the relationship between the partial productivities (capacity, internal and external as well as complexity and service performance is analyzed by using the structural equation modeling approach with partial least square method (PLS-SEM. The results indicate that the developed constructs have sufficient reliability, although the examination of validity highlights difficulties in quantifying service productivity and complexity. While a significant and substantial effect of internal and external efficiency on service performance could be proved, complexity influences performance only marginally and positively while capacity efficiency has no effect at all. Thus, further research is needed in order to foster the measurement model and to investigate possible nonlinear relationships between the constructs in more detail.

  16. Relationship Between Psychological Empowerment and Productivity of Medical Librarians.

    Science.gov (United States)

    Zare, Maliheh; Zarmehr, Fateme; Ashrafi-Rizi, Hasan

    2015-06-01

    Psychological empowerment is really important and has remarkable effect on different organizational variables such as job satisfaction, organizational commitment, productivity, etc. So the aim of this study was to investigate the relationship between psychological empowerment and productivity of Librarians in Isfahan Medical University. This was correlational research. Data were collected through two questionnaires. Psychological empowerment questionnaire and the manpower productivity questionnaire of Gold. Smith Hersey which their content validity was confirmed by experts and their reliability was obtained by using Cronbach's Alpha coefficient, 0.89 and 0.9 respectively. Due to limited statistical population, did not used sampling and review was taken via census. So 76 number of librarians were evaluated. Information were reported on both descriptive and inferential statistics (correlation coefficient tests Pearson, Spearman, T-test, ANOVA), and analyzed by using the SPSS19 software. In our study, the trust between partners and efficacy with productivity had the highest correlation. Also there was a direct relationship between psychological empowerment and the productivity of labor (r =0.204). In other words, with rising of mean score of psychological empowerment, the mean score of efficiency increase too. The results showed that if development programs of librarian's psychological empowerment increase in order to their productivity, librarians carry out their duties with better sense. Also with using the capabilities of librarians, the development of creativity with happen and organizational productivity will increase.

  17. Thallium-201 production at the National Medical Cyclotron

    International Nuclear Information System (INIS)

    Wood, N.R.

    1993-01-01

    The National Medical Cyclotron (NMC) began commercial production of thallium-201 chloride radiochemical solution in May 1993. This material is supplied to the laboratories of Australian Radioisotopes (ARI) at Lucas Heights where it is the active ingredient in the manufacture of the radiopharmaceutical thallous ( 201 Tl) chloride injection BP. Complete substitution of imported material will not occur immediately but should take place gradually over the next 12 months or so. The nuclear medicine community in Australia has shown an interest in such issues as price, availability and full Australian manufacturing capability of thallium-201 owing to its large-scale usage. This brief article explains how thallium-201 is generally made and how NMC production should evolve as experience in cyclotron production of radioisotopes begins to be accumulated in Australia

  18. Impact of mentoring medical students on scholarly productivity.

    Science.gov (United States)

    Svider, Peter F; Husain, Qasim; Mauro, Kevin M; Folbe, Adam J; Baredes, Soly; Eloy, Jean Anderson

    2014-02-01

    Our objectives were to evaluate collaboration with medical students and other nondoctoral authors, and assess whether mentoring such students influences the academic productivity of senior authors. Six issues of the Laryngoscope and International Forum of Allergy & Rhinology (IFAR) were examined for the corresponding author of each manuscript, and whether any students were involved in authorship. The h-index of all corresponding authors was calculated using the Scopus database to compare the scholarly impact of authors collaborating with students and those collaborating exclusively with other physicians or doctoral-level researchers. Of 261 Laryngoscope manuscripts, 71.6% had exclusively physician or doctoral-level authors, 9.2% had "students" (nondoctoral-level authors) as first authors, and another 19.2% involved "student" authors. Corresponding values for IFAR manuscripts were 57.1%, 6.3%, and 36.5%. Corresponding authors who collaborated with students had higher scholarly impact, as measured by the h-index, than those collaborating exclusively with physicians and doctoral-level scientists in both journals. Collaboration with individuals who do not have doctoral-level degrees, presumably medical students, has a strong association with scholarly impact among researchers publishing in the Laryngoscope and IFAR. Research mentorship of medical students interested in otolaryngology may allow a physician-scientist to evaluate the students' effectiveness and functioning in a team setting, a critical component of success in residency training, and may have beneficial effects on research productivity for the senior author. © 2013 ARS-AAOA, LLC.

  19. Production of medical 99 m Tc isotope via photonuclear reaction

    Science.gov (United States)

    Fujiwara, M.; Nakai, K.; Takahashi, N.; Hayakawa, T.; Shizuma, T.; Miyamoto, S.; Fan, G. T.; Takemoto, A.; Yamaguchi, M.; Nishimura, M.

    2017-01-01

    99 m Tc with a 6 hour half-life is one of the most important medical isotopes used for the Single-Photon Emission Computed Tomography (SPECT) inspection in hospitals of US, Canada, Europe and Japan. 99 m Tc isotopes are extracted by the milking method from parent 99Mo isotopes with a 66 hour half-life. The supply of 99Mo isotopes now encounters a serious crisis. Hospitals may not suitably receive 99Mo medical isotopes in near future, due to difficulties in production by research nuclear reactors. Many countries are now looking for alternative ways to generate 99Mo isotopes other than those with research reactors. We discuss a sustained availability of 99 m Tc isotopes via the nat Mo(γ, n) photonuclear reaction, and discuss to solve technical problems for extracting pure 99 m Tc isotopes from other output materials of photonuclear reactions.

  20. Estonian horticultural peat marketing: sales promotion and price formation. 2. part

    International Nuclear Information System (INIS)

    Hammer, Hele

    1999-01-01

    When forming prices, Estonian peat companies' decisions should be based on marginal cost analysis. Unfortunately most Estonian companies sell peat to intermediaries and cannot influence its price. Estonian peat producers have to choose between either selling peat directly or selling through a central marketing organization. Both systems have their pros and cons. Direct selling gives more freedom to individual producers but is more risky. Central marketing makes cost saving possible and is more effective and stable, but may alienate producers from clients and markets. Whichever marketing system Estonian peat companies choose, the most important elements in their marketing strategy should be: careful market analysis, personal sales, attending trade shows, catalogues, quality service and offering transportation services. (author)

  1. Problems of contemporary ecology. Temporal changes in Estonian nature and environment

    International Nuclear Information System (INIS)

    Frey, T.

    1997-01-01

    This conference was held 8-9 May 1997 at Tartu, Estonia. The proceedings of the 7. Estonian Conference in Ecology contain the results of mostly original research in environmental science, conservation and natural philosophy

  2. [Marge Rennit. Eesti muuseumid / Estonian museums] / Tapio Mäkeläinen

    Index Scriptorium Estoniae

    Mäkeläinen, Tapio

    2009-01-01

    Tutvustus: Eesti muuseumid = Estonian museums / [Eesti Muuseumiühing ; koostaja Marge Rennit ; tõlkija Tiina Mällo ; toimetaja Ivi Tammaru ; eessõna: Piret Õunapuu ; kujundaja Marek Allvee]. Tallinn : Oomen, 2008

  3. SAS paneb Estonian Airi kiirmüüki / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2009-01-01

    Majandusraskustes lennufirma SAS kavatseb loobuda osalustest kõigis lennufirmades, mis ei sobi kokku nende uue tegevuskavaga. Majandus- ja kommunikatsiooniminister Juhan Parts arvab, et riik peaks leidma Estonian Airile kodumaised partnerid

  4. Target-fueled nuclear reactor for medical isotope production

    Science.gov (United States)

    Coats, Richard L.; Parma, Edward J.

    2017-06-27

    A small, low-enriched, passively safe, low-power nuclear reactor comprises a core of target and fuel pins that can be processed to produce the medical isotope .sup.99Mo and other fission product isotopes. The fuel for the reactor and the targets for the .sup.99Mo production are the same. The fuel can be low enriched uranium oxide, enriched to less than 20% .sup.235U. The reactor power level can be 1 to 2 MW. The reactor is passively safe and maintains negative reactivity coefficients. The total radionuclide inventory in the reactor core is minimized since the fuel/target pins are removed and processed after 7 to 21 days.

  5. Evaluation of medical isotope production with the accelerator production of tritium (APT) facility

    International Nuclear Information System (INIS)

    Benjamin, R.W.; Frey, G.D.; McLean, D.C., Jr; Spicer, K.M.; Davis, S.E.; Baron, S.; Frysinger, J.R.; Blanpied, G.; Adcock, D.

    1997-01-01

    The accelerator production of tritium (APT) facility, with its high beam current and high beam energy, would be an ideal supplier of radioisotopes for medical research, imaging, and therapy. By-product radioisotopes will be produced in the APT window and target cooling systems and in the tungsten target through spallation, neutron, and proton interactions. High intensity proton fluxes are potentially available at three different energies for the production of proton- rich radioisotopes. Isotope production targets can be inserted into the blanket for production of neutron-rich isotopes. Currently, the major production sources of radioisotopes are either aging or abroad, or both. The use of radionuclides in nuclear medicine is growing and changing, both in terms of the number of nuclear medicine procedures being performed and in the rapidly expanding range of procedures and radioisotopes used. A large and varied demand is forecast, and the APT would be an ideal facility to satisfy that demand

  6. The Adaptation of the Motivation to Lead Instrument to the Estonian Military Context

    Directory of Open Access Journals (Sweden)

    Antek Kasemaa

    2016-03-01

    Full Text Available Purpose: This study is a contribution to the validation of the Motivation to Lead (MTL scale proposed by Chan and Drasgow (2001 in order to measure three types of motivation to be a leader: affective, social-normative and calculative. This research examines the psychometrical properties of the MTL scale in the Estonian context.Methodology: The sample of 517 military and non-military individuals from the Estonian Defence Forces, Estonian Police and students from Tallinn University participated in the study. The original MTL scale was expanded by with the addition of ideological and patriotic dimensions proposed by Amit and colleagues (2007. The factorial structure of the MTL Scale was analysed by using exploratory and confirmatory factor analysis (respectively N = 170 and N = 347.Findings: The results confirmed that both three- and five- component MTL scales are applicable in the Estonian context; the pool of 35 items was reduced into 25 items with good internal reliability. Moreover, the results showed correlations between leadership self-efficacy and MTL components,and differences between leaders’ and non-leaders’ MTL. The results indicate that the MTL scale can be a reliable and useful instrument to measure leadership motivation in the Estonian military context.Originality: This study is the first to adapt the MTL scale to the Estonian context. In addition, it examines the validity of ideological and patriotic MTL as part of the general MTL construct outside of the Israeli samples.

  7. Medical Isotope Production at TRIUMF - from Imaging to Treatment

    Science.gov (United States)

    Hoehr, C.; Bénard, F.; Buckley, K.; Crawford, J.; Gottberg, A.; Hanemaayer, V.; Kunz, P.; Ladouceur, K.; Radchenko, V.; Ramogida, C.; Robertson, A.; Ruth, T.; Zacchia, N.; Zeisler, S.; Schaffer, P.

    TRIUMF has a long history of medical isotope production. For more than 40 years, the Life Sciences Division at TRIUMF has produced isotopes for Positron Emission Tomography (PET) for the local hospitals. Recently, the division has taken on the challenge to expand the facility's isotope repertoire to isotopes for imaging to treatment. At the smallest cyclotron at TRIUMF with energy of 13 MeV, radiometals are being produced in a liquid target which is typically used for PET isotope production. This effort makes radiometals available for early stage research and preclinical trials. At beam energy of 24 MeV, we produce 99mTc from 100Mo with a cyclotron, the most common isotope for Single-Photon-Emission-Computed-Tomography (SPECT) and the most common isotope for nuclear imaging. The use of a cyclotron bypasses the common production route via a nuclear reactor as well as enriched uranium. And finally, at our 500 MeV cyclotron we have demonstrated the production of α emitters useful for targeted alpha therapy. Herein, these efforts are summarized.

  8. Production capabilities in US nuclear reactors for medical radioisotopes

    International Nuclear Information System (INIS)

    Mirzadeh, S.; Callahan, A.P.; Knapp, F.F. Jr.; Schenter, R.E.

    1992-11-01

    The availability of reactor-produced radioisotopes in the United States for use in medical research and nuclear medicine has traditionally depended on facilities which are an integral part of the US national laboratories and a few reactors at universities. One exception is the reactor in Sterling Forest, New York, originally operated as part of the Cintichem (Union Carbide) system, which is currently in the process of permanent shutdown. Since there are no industry-run reactors in the US, the national laboratories and universities thus play a critical role in providing reactor-produced radioisotopes for medical research and clinical use. The goal of this survey is to provide a comprehensive summary of these production capabilities. With the temporary shutdown of the Oak Ridge National Laboratory (ORNL) High Flux Isotope Reactor (HFIR) in November 1986, the radioisotopes required for DOE-supported radionuclide generators were made available at the Brookhaven National Laboratory (BNL) High Flux Beam Reactor (HFBR). In March 1988, however, the HFBR was temporarily shut down which forced investigators to look at other reactors for production of the radioisotopes. During this period the Missouri University Research Reactor (MURR) played an important role in providing these services. The HFIR resumed routine operation in July 1990 at 85 MW power, and the HFBR resumed operation in June 1991, at 30 MW power. At the time of the HFBR shutdown, there was no available comprehensive overview which could provide information on status of the reactors operating in the US and their capabilities for radioisotope production. The obvious need for a useful overview was thus the impetus for preparing this survey, which would provide an up-to-date summary of those reactors available in the US at both the DOE-funded national laboratories and at US universities where service irradiations are currently or expected to be conducted

  9. Production capabilities in US nuclear reactors for medical radioisotopes

    Energy Technology Data Exchange (ETDEWEB)

    Mirzadeh, S.; Callahan, A.P.; Knapp, F.F. Jr. (Oak Ridge National Lab., TN (United States)); Schenter, R.E. (Westinghouse Hanford Co., Richland, WA (United States))

    1992-11-01

    The availability of reactor-produced radioisotopes in the United States for use in medical research and nuclear medicine has traditionally depended on facilities which are an integral part of the US national laboratories and a few reactors at universities. One exception is the reactor in Sterling Forest, New York, originally operated as part of the Cintichem (Union Carbide) system, which is currently in the process of permanent shutdown. Since there are no industry-run reactors in the US, the national laboratories and universities thus play a critical role in providing reactor-produced radioisotopes for medical research and clinical use. The goal of this survey is to provide a comprehensive summary of these production capabilities. With the temporary shutdown of the Oak Ridge National Laboratory (ORNL) High Flux Isotope Reactor (HFIR) in November 1986, the radioisotopes required for DOE-supported radionuclide generators were made available at the Brookhaven National Laboratory (BNL) High Flux Beam Reactor (HFBR). In March 1988, however, the HFBR was temporarily shut down which forced investigators to look at other reactors for production of the radioisotopes. During this period the Missouri University Research Reactor (MURR) played an important role in providing these services. The HFIR resumed routine operation in July 1990 at 85 MW power, and the HFBR resumed operation in June 1991, at 30 MW power. At the time of the HFBR shutdown, there was no available comprehensive overview which could provide information on status of the reactors operating in the US and their capabilities for radioisotope production. The obvious need for a useful overview was thus the impetus for preparing this survey, which would provide an up-to-date summary of those reactors available in the US at both the DOE-funded national laboratories and at US universities where service irradiations are currently or expected to be conducted.

  10. Rahvusliku ajaloo tõlgendusi eesti draamas ja teatris 1970.–1980. aastatel. Interpretations of National History in Estonian Drama and Theatre in the 1970s–1980s

    Directory of Open Access Journals (Sweden)

    Piret Kruuspere

    2012-04-01

    Full Text Available According to theatre scholar Freddie Rokem, theatre portraying or performing historical events is seeking to overcome both the separation and the exclusion from the past, as well as ’striving to create a community where the events from this past will matter again’. This article covers the topic of interpretations of national history in Estonian theatre and in original dramaturgy during the Soviet era, with the focus on aspects like national self-reflection and the relationship to the common past. The main focus is on the 1970s, with examples from Rein Saluri’s, Mati Unt’s and Jaan Kaplinski’s drama productions. During the period in question, re-tellings of national history on Estonian theatre stages were clothed in metaphors, allusions and secret codes – Aesopian language. Within the Soviet cultural context, I analyse if and to what extent theatre of the time displayed resistance, political theatre or social allegory. Theatre was also connected with the principle of playing or playfulness, which on one hand indicates national resistance, national endurance, and a certain survival strategy, but on the other hand indicates the Estonian as being an involuntary homo ludens – the Playing Man, who through various enforced roles is trying to adjust to the whirlwinds of history. Saluri’s first play, the intellectual drama Külalised (The Guests, opens with an allusion to a drama classic the world over, William Shakespeare’s Hamlet, adding a powerful national-symbolic background to the play. The role-play which permeates and structures the play (The Host–The Guest however, displays allegorical references to changes in the status and self-image of Estonians. In Unt’s play Peaproov (Dress Rehearsal, the principle of playing/acting sheds ironic light on the makers of an historical film and their readiness to create superficially flashy interpretations at any cost: this take acts as an estranging and generalising reflection in a context

  11. Trace metal emissions from the Estonian oil shale fired power

    DEFF Research Database (Denmark)

    Aunela-Tapola, Leena A.; Frandsen, Flemming; Häsänen, Erkki K.

    1998-01-01

    a two-fraction particle sampling and subsequent absorption of the gaseous fraction. The analyses were principally performed with ICP-MS techniques. The trace metal contents of Estonian oil shale were found to be in the same order of magnitude as of coal on average. The high total particle concentrations...... in the flue gases of the studied oil shale plant contribute, however, to clearly higher total trace metal emission levels compared to modern coal fired power plants. Although the old electrostatic precipitators in the plant have been partly replaced by state-of-the-art electrostatic precipitators......, significant portions of some heavy metals (e.g., Hg, Cd, As and Pb) were found in the absorption liquids of the sampling line, indicating the presence of either vaporous metal species or metals condensed on very small particles in the flue gases. The experimental results were interpreted by theoretical...

  12. Production of titanium alloys for medical implants by powder metallurgy

    Energy Technology Data Exchange (ETDEWEB)

    Henriques, V.A.R. [Dept. de Engenharia de Materiais, Faculdade de Engenharia Quimica de Lorena, Lorena SP (Brazil); Silva, C.R.M. da [Div. de Materiais, CTA-IAE-AMR, Sao Jose dos Campos SP (Brazil)

    2001-07-01

    Titanium alloys are expected to be much more widely used for implant materials in the medical and dental fields because of their superior biocompatibility, corrosion resistance and specific strength compared with other metallic implant materials. Vanadium free alloys like Ti-6Al-7Nb and Ti-5Al-2,5Fe have been recently developed for biomedical use. More recently vanadium and aluminum free alloys composed of non-toxic elements like Nb, Ta, Zr and so on with lower modulus have been started to be developed. The {beta} type alloys like Ti-15Mo are now the main target for medical materials. A blended elemental titanium powder metallurgy process has been developed to offer low cost products. The process employs hydride-dehydride (HDH) powders and near-net shape techniques. In this work, the influence of the processing parameters and chemical composition of the elementary powders on the final microstructure was investigated. The alloys were characterized by means of scanning electron microscopy, X-ray diffraction, Vickers microhardness measurements, chemical analysis and density. The results indicate that the samples presented high densification, homogeneous chemical composition and coherent microstructures. The process parameters were defined aiming to reduce the interstitial pick-up (O, N) and to avoid the grain growth. (orig.)

  13. Production of Medical isotope Technecium-99 from DT Fusion neutrons

    Science.gov (United States)

    Boguski, John; Gentile, Charles; Ascione, George

    2011-10-01

    High energy neutrons produced in DT fusion reactors have a secondary application for use in the synthesis of valuable man-made isotopes utilized in industry today. One such isotope is metastable Technecium-99 (Tc99m), a low energy gamma emitter used in ~ 85% of all medical imaging diagnostics. Tc99m is created through beta decay of Molybdenum-99 (Mo99), which itself has only a 66 hour half-life and must be created from a neutron capture by the widely available and stable isotope Molydenum-98. Current worldwide production of Tc99m occurs in just five locations and relies on obtaining the fission byproduct Mo99 from highly enriched Uranium reactors. A Tc99m generator using DT fusion neutrons, however, could potentially be operated at individual hospitals and medical facilities without the use of any fissile material. The neutron interaction of the DT neutrons with Molybdenum in a potential device geometry was modeled using Monte Carlo neutron transport code MCNP. Trial experiments were also performed to test the viability of using DT neutrons to create ample quantities of Tc99m. Modeling and test results will follow.

  14. Development of key technology for the medical isotope production

    International Nuclear Information System (INIS)

    Oh, Soo Youl; Kim, I. S.; Kim, W. W.; Rhee, C. K.; Park, K. B.; Park, S. J.; Shin, H. S.; Shin, Y. J.

    2005-06-01

    The objective of this project is to experimentally verify and enhance Mo-99 and Sr-89 recovery/purification processes as the key technologies for the medical isotope production from a solution fuel reactor. A joint experiment was planned between KAERI and Kurchatov Institute (KI), Russia. The kinds of experiments planed are, a series of Mo-99 recovery/purification experiments from the ARGUS reactor which uses High Enriched Uranium (HEU) fuel, a series of the same experiments but from the Low Enriched Uranium (LEU) solution target, a demonstration of the mechanism of Sr-89 delivery from the air medium in the reactor vessel. Meanwhile, the survey and legalistic interpretation of relevant patents shows a possibility of infringement of TCI Inc.'s patents in case of exporting medical isotopes produced at the MIP to Japan and the US so far as the MIP adopts the concept of the Russian ARGUS and recovery/purification process. Eliminating, not minor changing, step(s) or condition(s) of patent processes would help to avoid the patent infringement. Because of a difficulty in the KAERI-KI full-time co-experiments at KI labs, a different idea between two parties about the depth of background information to be provided to KAERI, and other reasons, the experiment plan was not executed

  15. Activation of air and concrete in medical isotope production facilities

    Science.gov (United States)

    Dodd, Adam C.; Shackelton, R. J.; Carr, D. A.; Ismail, A.

    2017-05-01

    Medical isotope facilities operating in the 10 to 25 MeV proton energy range have long been used to generate radioisotopes for medical diagnostic imaging. In the last few years the beam currents available in commercially available cyclotrons have increased dramatically, and so the activation of the materials within cyclotron vaults may now pose more serious radiological hazards. This will impact the regulatory oversight of cyclotron operations, cyclotron servicing and future decommissioning activities. Air activation could pose a hazard to cyclotron staff. With the increased cyclotron beam currents it was necessary to examine the issue more carefully. Therefore the ways in which radioactivity may be induced in air by neutron reactions and neutron captures were considered and it was found that the dominant mechanism is neutron capture on Ar-40. A study of the activation of the air by neutron capture on Ar-40 within a cyclotron vault was performed using the MCNP Monte Carlo code. The neutron source energy spectrum used was from the production of the widely used F-18 PET isotope. The results showed that the activation of the air within a cyclotron vault does not pose a significant radiological hazard at the beam intensities currently in use and shows how ventilation affects the results. A second MCNP study on the activation of ordinary concrete in cyclotron vaults by neutron capture was made with a view to determining the optimum thickness of borated polyethylene to reduce neutron activation on both the inner surfaces of the vault and around production targets. This is of importance in decommissioning cyclotrons and therefore in the design of new cyclotron vaults. The distribution of activation on the walls as a function of the source position was also studied. Results are presented for both borated and regular polyethylene, and F-18 and Tc-99 neutron spectra.

  16. Research reactor production of radioisotopes for medical use

    International Nuclear Information System (INIS)

    Mani, R.S.

    1985-01-01

    More than 70% of all radioisotopes applied in medical diagnosis and research are currently produced in research reactors. Research reactors are also an important source of certain radioisotopes, such as 60 Co, 90 Y, 137 Cs and 198 Au, which are employed in teletherapy and brachytherapy. For regular medical applications, mainly 29 radionuclides produced in research reactors are used. These are now produced on an 'industrial scale' by many leading commercial manufacturers in industrialized countries as well as by national atomic energy establishments in developing countries. Five main neutron-induced reactions have been employed for the regular production of these radionuclides, namely: (n,γ), (n,p), (n,α), (n,γ) followed by decay, and (n, fission). In addition, the Szilard-Chalmers process has been used in low- and medium-flux research reactors to enrich the specific activity of a few radionuclides (mainly 51 Cr) produced by the (n,γ) reaction. Extensive work done over the last three decades has resulted in the development of reliable and economic large-scale production methods for most of these radioisotopes and in the establishment of rigorous specifications and purity criteria for their manifold applications in medicine. A useful spectrum of other radionuclides with suitable half-lives and low to medium toxicity can be produced in research reactors, with the requisite purity and specific activity and at a reasonable cost, to be used as tracers. Thanks to the systematic work done in recent years by many radiopharmaceutical scientists, the radionuclides of several elements, such as arsenic, selenium, rhenium, ruthenium, palladium, cadmium, tellurium, antimony, platinum, lead and the rare earth elements, which until recently were considered 'exotic' in the biomedical field, are now gaining attention. (author)

  17. The power of management in medical services. Can we manage better for higher quality and more productive medical services?

    Directory of Open Access Journals (Sweden)

    Magdalena BARBU

    2010-06-01

    Full Text Available Medical services are the most important services of all since we all depend on them. Their quality and productivity can assure a wealthy nation and therefore good economical results. The offer of medical services depends on medical personnel and more than this, on the management in the medical field since any resource not managed well or not managed at all is only a lost one, regardless its value. Management is therefore the key, the “how to” method of obtaining the desired result. The same approach can be applied into our study in order to reach more productive medical services which to prove high quality to all patients. We need to use and to squeeze the entire force of management tools in order to reach our goal: accessible medical services full of quality. The current worldwide crisis situation makes us think that after job and food, even medical services (also a basic thing after all can become a “luxury” although this should never happen. Therefore we must do whatever needed to improve the way medical organizations are driven so that the quality of their medical services will be better and better and the productivity will be at a higher level. Medical management should have as a goal making it possible for patients to be able to solve their health problems as soon as possible and as good as possible.

  18. [Development of guidance for the approval process of brand-new medical products and regenerative medicine products].

    Science.gov (United States)

    Niimi, Shingo

    2015-01-01

    Ministry of Health, Labour and Weltare has been conducting development of guidance for the approval process of brand-new medical products/development of guidance for medical devices in collaboration with Ministry of Economy, Trade and Industry as part of measures to promote practical use of brand-new medical products since 2005. The objective of this project is to expedite the processes from developmental process of medical devices to approval review and to introduce the medical devices to medical front quickly.. Ministry of Health, Labour and Welfare side has been making guidance for the guide in approval process of brand-new medical products and regeneration medicine products to aim at acceleration and facilitation of development and approval process of innovative medical products. Twenty-two of the guidance have been issued as director of the evaluation and licensing division. The evaluation index about safety and efficacy required for medical devices and regenerative medicine products in progress were put together in these guidance and useful for medical devices developer to understand the point at the approved review. Therefore, I think that the evaluation index could also contribute to the efficient product development. The guidance about implantable artificial heart is issued as the representative example which was useful in the approved review.

  19. The Effect of the 2008 War on Estonian Public Confidence in International Organisations: A Mixed Methods Study

    NARCIS (Netherlands)

    Moes, Jeroen; Melchior, Inge; Gugushvili, Alexi

    2014-01-01

    When the so-called 5 Day War between Russia and Georgia occurred in the summer of 2008, the Estonian public reaction was especially passionate. Two major explanations stem from the strong identification of Estonians with the situation of Georgia (post-Soviet state, small country, Russian

  20. Jäätmetega kimpus Estonian Cell annab muda põldudele kompostiks / Ulvar Käärt

    Index Scriptorium Estoniae

    Käärt, Ulvar, 1982-

    2007-01-01

    Kundas asuv Estonian Celli tehas jagab ümberkaudsetele talunikele jäätmetest lahtisaamiseks kompostimissegu. Seadused ei sätesta, kuidas Estonian Cellis tekkivaid jäätmeid töödelda. Kommenteerib Peeter Eek: Aasta läbi ei saa muda põllule viia

  1. Musical Practices and Methods in Music Lessons: A Comparative Study of Estonian and Finnish General Music Education

    Science.gov (United States)

    Sepp, Anu; Ruokonen, Inkeri; Ruismäki, Heikki

    2015-01-01

    This article reveals the results of a comparative study of Estonian and Finnish general music education. The aim was to find out what music teaching practices and approaches/methods were mostly used, what music education perspectives supported those practices. The data were collected using questionnaires and the results of 107 Estonian and 50…

  2. Supervision, mentorship and peer networks: how Estonian early career researchers get (or fail to get support

    Directory of Open Access Journals (Sweden)

    Jaana Eigi

    2018-03-01

    Full Text Available The paper analyses issues related to supervision and support of early career researchers in Estonian academia. We use nine focus groups interviews conducted in 2015 with representatives of social sciences in order to identify early career researchers’ needs with respect to support, frustrations they may experience, and resources they may have for addressing them. Our crucial contribution is the identification of wider support networks of peers and colleagues that may compensate, partially or even fully, for failures of official supervision. On the basis of our analysis we argue that support for early career researchers should take into account the resources they already possess but also recognise the importance of wider academic culture, including funding and employment patterns, and the roles of supervisors and senior researchers in ensuring successful functioning of support networks. Through analysing the conditions for the development of early career researchers – producers of knowledge – our paper contributes to social epistemology understood as analysis of specific forms of social organisation of knowledge production.

  3. On the System of Place Name Signs in Estonian Sign Language

    Directory of Open Access Journals (Sweden)

    Liina Paales

    2011-05-01

    Full Text Available A place name sign is a linguistic-cultural marker that includes both memory and landscape. The author regards toponymic signs in Estonian Sign Language as representations of images held by the Estonian Deaf community: they reflect the geographical place, the period, the relationships of the Deaf community with hearing community, and the common and distinguishing features of the two cultures perceived by community's members. Name signs represent an element of signlore, which includes various types of creative linguistic play. There are stories hidden behind the place name signs that reveal the etymological origin of place name signs and reflect the community's memory. The purpose of this article is twofold. Firstly, it aims to introduce Estonian place name signs as Deaf signlore forms, analyse their structure and specify the main formation methods. Secondly, it interprets place-denoting signs in the light of understanding the foundations of Estonian Sign Language, Estonian Deaf education and education history, the traditions of local Deaf communities, and also of the cultural and local traditions of the dominant hearing communities. Both perspectives - linguistic and folkloristic - are represented in the current article.

  4. The Problems of Estonian R&D and Innovation Strategy and the Demand-Side Innovation Policies

    Directory of Open Access Journals (Sweden)

    Tõnu Roolaht

    2012-12-01

    Full Text Available The second larger Estonian R&D and Innovation Strategy ‘Knowledge-based Estonia 2007-2013’ is aimed at continuing the advancement of research and development efforts towards an innovative knowledge-based society and economic system in Estonia. Fostering of knowledge-based high-tech industries is seen as paramount for retaining country’s competitive advantage. However, the mid-term evaluations indicate that several goals of the strategy might not be achievable by 2013. In fact, the policy measures have been much more successful in developing scientific research, as indicated by increased international publication, number of patents, and number of researchers and engineers. The advances in development of high-tech products and services through innovations are noticeable but less prominent. The purpose of this study is to suggest the role for demand-side innovation policies in helping to advance commercial development and innovation

  5. Radioisotope Productions for Medical Use with Accelerator Neutrons

    Science.gov (United States)

    Minato, Futoshi; Nagai, Yasuki; Iwamoto, Nobuyuki; Iwamoto, Osamu

    2014-09-01

    Various kinds of radioactive isotopes (RIs) are widely used in nuclear medicine for diagnostics and therapy. Since the RIs are not usually present in the nature, they must be produced by nuclear reactors and accelerators. For instance, 99mTc, which is the most common RI used in diagnosis, is mainly produced by fission of highly enriched 235U (HEU) in nuclear reactors. However, use of the HEU is unfavorable in terms of nuclear security. Therefore, many methods without 235U have been studied in order to produce RIs for medical use; for example, thermal neutron capture, gamma disintegration, and proton induced reactions. We also have proposed an alternative method using accelerator neutrons besides the above methods. Technique producing high intense accelerator neutron beam as much as 1015 n/s is being developed and RI productions with the accelerator neutron have been done recently. The major advantages of the use of accelerator neutron are followings. 1) A wide variety of carrier-added and carrier-free radioisotopes can be produced using the neutrons, because a charge exchange reaction of a sample nucleus has a sizable cross section of 50 to 500 mb. 2) High transparency of neutron allows us to use a large amount of sample to co-produce other RIs by putting other samples behind the main sample in the beam direction. In this talk, we will show the features of RI productions with accelerator neutron which we have ever investigated and found, along with numerical results of RI yields calculated with Japanese Evaluated Nuclear Data Library (JENDL-4.0).

  6. ISBT 128 Standard for Coding Medical Products of Human Origin.

    Science.gov (United States)

    Ashford, Paul; Delgado, Matthew

    2017-11-01

    ISBT 128 is an international standard for the terminology, coding, labeling, and identification of medical products of human origin (MPHO). Full implementation of ISBT 128 improves traceability, transparency, vigilance and surveillance, and interoperability. ICCBBA maintains the ISBT 128 standard through the activities of a network of expert volunteers, including representatives from professional scientific societies, governments and users, to standardize and maintain MPHO identification. These individuals are organized into Technical Advisory Groups and work within a structured framework as part of a quality-controlled standards development process. The extensive involvement of international scientific and professional societies in the development of the standard has ensured that ISBT 128 has gained widespread recognition. The user community has developed confidence in the ability of the standard to adapt to new developments in their fields of interest. The standard is fully compatible with Single European Code requirements for tissues and cells and is utilized by many European tissue establishments. ISBT 128's flexibility and robustness has allowed for expansions into subject areas such as cellular therapy, regenerative medicine, and tissue banking. ISBT 128 is the internationally recognized standard for coding MPHO and has gained widespread use globally throughout the past two decades.

  7. Feasibility study of medical isotope production at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Massey, C.D.; Miller, D.L.; Carson, S.D.

    1995-12-01

    In late 1994, Sandia National Laboratories in Albuquerque, New Mexico, (SNL/NM), was instructed by the Department of Energy (DOE) Isotope Production and Distribution Program (IPDP) to examine the feasibility of producing medically useful radioisotopes using the Annular Core Research Reactor (ACRR) and the Hot Cell Facility (HCF). Los Alamos National Laboratory (LANL) would be expected to supply the targets to be irradiated in the ACRR. The intent of DOE would be to provide a capability to satisfy the North American health care system demand for 99 Mo, the parent of 99m Tc, in the event of an interruption in the current Canadian supply. 99m Tc is used in 70 to 80% of all nuclear medicine procedures in the US. The goal of the SNL/NM study effort is to determine the physical plant capability, infrastructure, and staffing necessary to meet the North American need for 99 Mo and to identify and examine all issues with potential for environmental impact

  8. Feasibility study of medical isotope production at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    Massey, C.D.; Miller, D.L.; Carson, S.D. [Sandia National Labs., Albuquerque, NM (United States). Environmental Regulatory Assessment Dept.] [and others

    1995-12-01

    In late 1994, Sandia National Laboratories in Albuquerque, New Mexico, (SNL/NM), was instructed by the Department of Energy (DOE) Isotope Production and Distribution Program (IPDP) to examine the feasibility of producing medically useful radioisotopes using the Annular Core Research Reactor (ACRR) and the Hot Cell Facility (HCF). Los Alamos National Laboratory (LANL) would be expected to supply the targets to be irradiated in the ACRR. The intent of DOE would be to provide a capability to satisfy the North American health care system demand for {sup 99}Mo, the parent of {sup 99m}Tc, in the event of an interruption in the current Canadian supply. {sup 99m}Tc is used in 70 to 80% of all nuclear medicine procedures in the US. The goal of the SNL/NM study effort is to determine the physical plant capability, infrastructure, and staffing necessary to meet the North American need for {sup 99}Mo and to identify and examine all issues with potential for environmental impact.

  9. Genetic parameters for milk coagulation properties in Estonian Holstein cows.

    Science.gov (United States)

    Vallas, M; Bovenhuis, H; Kaart, T; Pärna, K; Kiiman, H; Pärna, E

    2010-08-01

    The objective of this study was to estimate heritabilities and repeatabilities for milk coagulation traits [milk coagulation time (RCT) and curd firmness (E(30))] and genetic and phenotypic correlations between milk yield and composition traits (milk fat percentage and protein percentage, urea, somatic cell count, pH) in first-lactation Estonian Holstein dairy cattle. A total of 17,577 test-day records from 4,191 Estonian Holstein cows in 73 herds across the country were collected during routine milk recordings. Measurements of RCT and E(30) determined with the Optigraph (Ysebaert, Frepillon, France) are based on an optical signal in the near-infrared region. The cows had at least 3 measurements taken during the period from April 2005 to January 2009. Data were analyzed using a repeatability animal model. There was substantial variation in milk coagulation traits with a coefficient of variation of 27% for E(30) and 9% for the log-transformed RCT. The percentage of variation explained by herd was 3% for E(30) and 4% for RCT, suggesting that milk coagulation traits are not strongly affected by herd conditions (e.g., feeding). Heritability was 0.28 for RCT and 0.41 for E(30), and repeatability estimates were 0.45 and 0.50, respectively. Genetic correlation between both milk coagulation traits was negligible, suggesting that RCT and E(30) have genetically different foundations. Milk coagulation time had a moderately high positive genetic (0.69) and phenotypic (0.61) correlation with milk pH indicating that a high pH is related to a less favorable RCT. Curd firmness had a moderate positive genetic (0.48) and phenotypic (0.45) correlation with the protein percentage. Therefore, a high protein percentage is associated with favorable curd firmness. All reported genetic parameters were statistically significantly different from zero. Additional univariate random regression analysis for milk coagulation traits yielded slightly higher average heritabilities of 0.38 and 0

  10. Compiling the Dictionary of Word Associations in Estonian: From scratch to the database

    Directory of Open Access Journals (Sweden)

    Ene Vainik

    2018-04-01

    Full Text Available The present paper describes the project titled “The Dictionary of Word Associations in Estonian” undertaken by the author at the Institute of the Estonian Language. The general aim of the Dictionary is to provide insights into Estonians’ common-sense mind. It is meant to be a tool of self-reflection for Estonian native speakers and a guide for the foreigners who are eager enough to make themselves familiar with the Estonian cultural patterns of thought. The Dictionary will be published online. The number of keywords was initially limited to approximately 800. Specific emphasis is given to the stage of data collection by implementing the principles of citizen science.

  11. Antimicrobial Resistance Profiles of Campylobacter spp. Isolated from Broiler Chicken Meat of Estonian, Latvian and Lithuanian Origin at Estonian Retail Level and from Patients with Severe Enteric Infections in Estonia.

    Science.gov (United States)

    Mäesaar, M; Kramarenko, T; Meremäe, K; Sõgel, J; Lillenberg, M; Häkkinen, L; Ivanova, M; Kovalenko, K; Hörman, A; Hänninen, M-L; Roasto, M

    2016-03-01

    The resistance patterns of Campylobacter spp. isolated from retail broiler chicken meat originating either from Estonia, Lithuania or Latvia collected in Estonia were determined. Additionally, in collaboration with the laboratories of several Estonian hospitals, antimicrobial susceptibility patterns were determined for Campylobacter isolates from patients with severe Campylobacter enteric infections. The isolates were identified at the species level by the PCR method. Respectively, 88.8% of the isolates were C. jejuni, and 11.2% were C. coli. In total, 126 Campylobacter isolates of broiler chicken meat and human origin were tested for minimal inhibitory concentrations (MICs) with the broth microdilution VetMIC(TH) method (National Veterinary Institute; Uppsala, Sweden) for a total of six antimicrobials. Resistance to one or more antimicrobials was detected in 62 (63.3%) of Campylobacter broiler chicken meat isolates and in 20 (71.4%) of human-origin isolates. Large proportions of the broiler chicken meat isolates were resistant to ciprofloxacin (60.2%). Multidrug resistance (i.e. to three or more unrelated antimicrobials) was detected in five (5.1%) C. jejuni isolates. Among the human isolates, 20 (71.4%) were resistant to fluoroquinolones, and two (7.1%) C. jejuni isolates exhibited multidrug resistance. The chicken meat isolates of Estonian origin were the most susceptible. However, a high proportion of fluoroquinolone-resistant C. jejuni isolates were found in Latvian and Lithuanian products. The results of this study indicate that the problems caused by the inappropriate use of antimicrobials extend beyond the country in which a food originates; therefore, both domestic and international interventions and agreements are required to implement common policies on antimicrobial usage and to minimize the emergence of Campylobacter drug resistance. © 2015 Blackwell Verlag GmbH.

  12. The Woman as Wolf (AT 409: Some Interpretations of a Very Estonian Folk Tale

    Directory of Open Access Journals (Sweden)

    Merili Metsvahi

    2013-12-01

    Full Text Available The article analyses tale type The Woman as Wolf, which is one of the most popular folk tales in the Estonian Folklore Archives and is represented there both in the form of a fairy tale and in the form of a legend. The vast majority of the versions of The Woman as Wolf were written down in the first part of the 20th century within Estonia and where recorded from Estonians. The article introduces the content of the tale, the origin of the first records from the early 19th century, and the dissemination area of the tale, which remains outside Western Europe: apart from the Estonian versions there are Sami, Karelian, Vepsian, Livonian, Latvian, Lithuanian, Russian, Ukrainian and Belarusian versions. While in almost all the Estonian versions the main protagonist is transformed into a wolf, in most of the versions written down in other areas and ethnic groups, another animal or bird replaces the wolf. The author is of the opinion that the Finnic area is central to the distribution of the folk tale The Woman as Wolf. The animal the woman is transformed into in the plot would not have been a wolf in earlier times. The article provides an explanation why the wolf is predominant in Estonian written sources. For that purpose the ways in which the wolf and werewolf were perceived in earlier Estonian folk belief are introduced. At the end of the article interpretation of the folk tale is provided. The author states that the plot and some of the motifs found in this folk tale reflect the difficulties women had in submitting to the norms and values of patriarchal order within their society.

  13. The Woman as Wolf (AT 409: Some Interpretations of a Very Estonian Folk Tale

    Directory of Open Access Journals (Sweden)

    Merili Metsvahi

    2014-01-01

    Full Text Available The article analyses tale type The Woman as Wolf, which is one of the most popular folk tales in the Estonian Folklore Archives and is represented there both in the form of a fairy tale and in the form of a legend. The vast majority of the versions of The Woman as Wolf were written down in the first part of the 20th century within Estonia and where recorded from Estonians. The article introduces the content of the tale, the origin of the first records from the early 19th century, and the dissemination area of the tale, which remains outside Western Europe: apart from the Estonian versions there are Sami, Karelian, Vepsian, Livonian, Latvian, Lithuanian, Russian, Ukrainian and Belarusian versions. While in almost all the Estonian versions the main protagonist is transformed into a wolf, in most of the versions written down in other areas and ethnic groups, another animal or bird replaces the wolf. The author is of the opinion that the Finnic area is central to the distribution of the folk tale The Woman as Wolf. The animal the woman is transformed into in the plot would not have been a wolf in earlier times. The article provides an explanation why the wolf is predominant in Estonian written sources. For that purpose the ways in which the wolf and werewolf were perceived in earlier Estonian folk belief are introduced. At the end of the article interpretation of the folk tale is provided. The author states that the plot and some of the motifs found in this folk tale reflect the difficulties women had in submitting to the norms and values of patriarchal order within their society.

  14. MODELLING DICLOFENAC AND IBUPROFEN RESIDUES IN MAJOR ESTONIAN SEASIDE CITIES

    Directory of Open Access Journals (Sweden)

    Erki Lember

    2016-06-01

    Full Text Available A theoretical model was developed to model the fate of two common pharmaceutical residues: diclofenac and ibuprofen in eight Estonian seaside cities that discharge their wastewaters directly into the Baltic Sea. The consumption rates of the active ingredients of diclofenac and ibuprofen from 2006-2014 were analysed. A decrease of 19.9% for diclofenac consumption and an increase of 14.1% for ibuprofen were found. The fate of diclofenac and ibuprofen were modelled by considering the human metabolism removal rate for pharmaceuticals, the removal rate of diclofenac and ibuprofen in activated sludge wastewater treatment plants (WWTP and annual flow rates. An average decrease from 1 to 0.8 µg/l (decrease of 20% for diclofenac and an increase from 11.4 to 13.4 µg/l (increase of 14.9% for ibuprofen for the concentration in the effluents of the WWTP were modelled. The model gives us a good overview about the theoretical concentrations of pharmaceutical residues in the environment and is helpful for evaluating environmental impacts.

  15. The figure of the teacher in Estonian school discourse

    Directory of Open Access Journals (Sweden)

    Ott Puumeister

    2014-10-01

    Full Text Available The article concerns itself with the figure of the teacher in Estonian society. We do not concentrate on the educational system as a whole, but on one specific and crucial element in this apparatus - the teacher. We begin by offering a brief historical overview of the conditions of pedagogues in the 20th century before moving on to describe the adoption of neo-liberal free market policies since the 1990s and the effects these policies had and still have on education. Our main concern is to understand the teacher as an actor in power relations; to achieve this understanding we have selected as our examples 1 surveillance techniques in school environment that have direct relations to the state and the market; and 2 the 2012 educational workers' strike that made it quite clear that the teachers have been fixed to a position of wage workers. The overall and more abstract aim of the paper is to think about the social role of the teacher in Estonia.

  16. Estonian Perceptions of Security: Not Only About Russia and the Refugees

    Directory of Open Access Journals (Sweden)

    Veebel Viljar

    2016-12-01

    Full Text Available The current study focuses on the Estonian perceptions of security and on the defence situation both globally and locally. The dynamic results of the public opinion surveys on security risks conducted in Estonia over the last 10 years (2006-2016 will be presented. In addition, to understand whether some of the security risks could be over- or underestimated in Estonia, these results will be compared with the views expressed recently by the World Economic Forum, particularly the Global Risks Report 2016. Also, the arguments why some topics have played or are currently playing key role in the Estonian security perception will be presented and discussed.

  17. [Precautions of physical performance requirements and test methods during product standard drafting process of medical devices].

    Science.gov (United States)

    Song, Jin-Zi; Wan, Min; Xu, Hui; Yao, Xiu-Jun; Zhang, Bo; Wang, Jin-Hong

    2009-09-01

    The major idea of this article is to discuss standardization and normalization for the product standard of medical devices. Analyze the problem related to the physical performance requirements and test methods during product standard drafting process and make corresponding suggestions.

  18. MedWatch Safety Alerts for Human Medical Products

    Data.gov (United States)

    U.S. Department of Health & Human Services — MedWatch alerts provide timely new safety information on human drugs, medical devices, vaccines and other biologics, dietary supplements, and cosmetics. The alerts...

  19. Personality traits and eating habits in a large sample of Estonians.

    Science.gov (United States)

    Mõttus, René; Realo, Anu; Allik, Jüri; Deary, Ian J; Esko, Tõnu; Metspalu, Andres

    2012-11-01

    Diet has health consequences, which makes knowing the psychological correlates of dietary habits important. Associations between dietary habits and personality traits were examined in a large sample of Estonians (N = 1,691) aged between 18 and 89 years. Dietary habits were measured using 11 items, which grouped into two factors reflecting (a) health aware and (b) traditional dietary patterns. The health aware diet factor was defined by eating more cereal and dairy products, fish, vegetables and fruits. The traditional diet factor was defined by eating more potatoes, meat and meat products, and bread. Personality was assessed by participants themselves and by people who knew them well. The questionnaire used was the NEO Personality Inventory-3, which measures the Five-Factor Model personality broad traits of Neuroticism, Extraversion, Openness, Agreeableness, and Conscientiousness, along with six facets for each trait. Gender, age and educational level were controlled for. Higher scores on the health aware diet factor were associated with lower Neuroticism, and higher Extraversion, Openness and Conscientiousness (effect sizes were modest: r = .11 to 0.17 in self-ratings, and r = .08 to 0.11 in informant-ratings, ps < 0.01 or lower). Higher scores on the traditional diet factor were related to lower levels of Openness (r = -0.14 and -0.13, p < .001, self- and informant-ratings, respectively). Endorsement of healthy and avoidance of traditional dietary items are associated with people's personality trait levels, especially higher Openness. The results may inform dietary interventions with respect to possible barriers to diet change.

  20. The problems and development potential of revenue autonomy in Estonian municipalities. Kohalike omavalitsuste tuluautonoomia probleemid ja arenguvõimalused Eestis

    Directory of Open Access Journals (Sweden)

    Janno Reiljan

    2013-01-01

    Full Text Available In a regionally heterogeneous country like Estonia, it is a difficult task to create a local government revenue structure that guarantees even supply of public services across the entire country and, at the same time, revenue autonomy for the municipalities. In the theoretical part of the current article the suitability of different sources of own revenues are analysed in the context of Estonian municipalities. The empirical part of the article compares the financing principles of Estonian municipalities with other EU countries. Finally, the proportions of different own sources of revenues in the budgets of Estonian local governments are examined and suggestions are made for changing the current system

  1. The Estonian diaspora in South-West Russia in the 1920—30s: migration results

    Directory of Open Access Journals (Sweden)

    Stupin Yuri

    2010-11-01

    Full Text Available This article analyses the spatial features of the settling of Russian Estonians in the Northwest region at the “zenith” of diaspora on the basis of 1920, 1926, and 1939 censuses. The author identifies the principal settling areas and points out the geographical preconditions for the rapid decline of the diaspora.

  2. Gender Advantages and Gender Normality in the Views of Estonian Secondary School Students

    Science.gov (United States)

    Kuurme, Tiiu; Kasemaa, Gertrud

    2015-01-01

    The aim of the study on Estonian secondary school students was to obtain an overview of the gender-related views and experiences of the everyday school life by students, and to analyse the school-related factors in the development of gender roles and gender-related expectations. We view gender equality as a central condition for social…

  3. Alberta's Estonians 1899 - Present TLÜ Akadeemilises Raamatukogus / Sander Jürisson

    Index Scriptorium Estoniae

    Jürisson, Sander

    2014-01-01

    Tallinna Ülikooli Akadeemilises Raamatukogus on üleval näitus "Alberta's Estonians 1899 - Present", mis annab ülevaate Kanada Alberta provintsi eestlaste loost. Näitus valmis Alberta Eesti Kultuuripärandi Seltsi koostöös Alberta Provintsi Arhiivi Kultuuripärandi Osakonnaga Edmontonis

  4. The Perceived Impact of External Evaluation: The System, Organisation and Individual Levels-Estonian Case

    Science.gov (United States)

    Seema, Riin; Udam, Maiki; Mattisen, Heli; Lauri, Liia

    2017-01-01

    The purpose of this article is to provide an overview of how the employees of higher education institutions perceive the impact of external evaluations. The study was conducted using the concurrent mixed method and involved 361 employees from Estonian universities and professional higher education institutions. The results indicated that…

  5. Consumer Socialisation and Value Orientations among Estonian and Chinese Young People

    Science.gov (United States)

    Waerdahl, Randi; Kalmus, Veronika; Keller, Margit

    2011-01-01

    This paper asks if Estonian and Chinese tweens' access to pocket money influences their brand valuation, as well as value orientations in the context of perceived peer popularity and personal well-being. Surveys conducted in autumns 2006 (China n = 188) and 2007 (Estonia n = 111) show an inherent cultural resistance among tweens in both countries…

  6. Estonian Air võitis reisijaid juurde. Samas turuosa vähenes

    Index Scriptorium Estoniae

    2011-01-01

    Estonian Airi turuosa vähenes Tallinna lennujaamas regulaarliinidel 2010. aastal võrreldes 2009. aastaga 3,9% võrra, lende toimus 1,8% rohkem kui 2009. a. Lendude toimumise protsent oli 98,1, väljumise täpsus oli 86,7%. Andmeid ka 2010. aasta detsembrikuu kohta

  7. Tiger in Focus--A National Survey of ICT in Estonian Schools

    Science.gov (United States)

    Toots, Anu; Laanpere, Mart

    2004-01-01

    Estonia has not participated in international studies of ICT in education, nor have there been any similar studies at the national level up until the year 2000. The first survey of ICT in Estonian schools was conducted after completion of the national school computerization programme called Tiger Leap. This paper focuses on the targeted responses…

  8. Estonian Cell peab suu kasumist puhtaks pühkima / Kaisa Tahlfeld, Katre Pilvinski

    Index Scriptorium Estoniae

    Tahlfeld, Kaisa

    2008-01-01

    Estonian Cell saatis valitsusele pöördumise, milles palutakse teha parandusi elektrienergiaga seonduvates seadustes, mis aitaksid ettevõtet energia hinnatõusu ajal. Elektri hinnatõusu tõttu on muutunud küsitavaks ka Nitroferti tehase edasine eksisteerimine

  9. SAS võib omapoolse panusena kustutada osa Estonian Airi laenust / Gert D. Hankewitz

    Index Scriptorium Estoniae

    Hankewitz, Gert D.

    2011-01-01

    Lennufirma SAS investorsuhete asepresidendi Sture Stoleni sõnul ei ole tõenäoline, et nende firma maksaks mingit raha Estonian Airi kapitali, küll aga ei saa välistada võimalust, et võidakse kustutada osa antud laenust

  10. Present status in radiation sterilization of medical products

    International Nuclear Information System (INIS)

    Sato, Kenji

    1982-01-01

    The attempt to sterilize the disposable medical supplies of plastics and protein by radiation started as early as 1958. In the world, more than 80 such installations have been set up and operated at present. In recent years, the guarantee for sterilization has been emphasized; the trend is now for the worldwise standardization of the process control and the method of determining sterilization radiation dose. In Japan, there exist three installations equipped with 60 Co gamma -ray irradiation apparatus. The medical supplies over 20 items including artificial kidney dialyzer, injection needles and surgical stitches are radiation sterilized and practically used presently. The following matters are described: radiation sterilization facilities, sterilization process control, sterilization conditions (radiation dose), the radiation resistance of microorganisms, radiation-sterilized medical supplies. (Mori, K.)

  11. Noor eesti teater ja Noor-Eesti. Young Estonian Theatre and Young Estonia

    Directory of Open Access Journals (Sweden)

    Katri Aaslav-Tepandi

    2012-04-01

    Full Text Available This article begins by examining points of intersection between two professional theatres, ”Estonia” and ”Vanemuine” (both established in 1906, their young directors – Karl Menning, Paul Pinna, Theodor Altermann, and Karl Jungholz, and the literary movement Young Estonia. Subsequently, we will consider Young Estonia’s theatrical ideals and the influence of these ideas on later Estonian theatrical life. Since not much information has survived regarding direct personal contacts between ”movers and shakers” in the theatre world and Young Estonians, the main focus here shall be on indirect creative connections and influences. One such context is education: like the Young Estonians, theatre activists of the younger generation aspired to place themselves on the larger map of European culture. Thus, their artistic beliefs and goals shall be examined in relation to those of Young Estonians’ quest for modern culture. Pinna, Altermann, Menning, Jungholz, and others went on study tours to Germany and France, where they were energized and inspired by innovative German and Russian theatres, by naturalistic staging, and by psychological realism, both in acting and in performance style. Among their models were A. Antoine’s Théâtre- Libre in Paris, K. Stanislavski’s Art Theatre in Moscow, O. Brahm’s Lessing-Theater, and M. Reinhardt’s Deutsches Theater in Berlin. These models were likewise known to the Young Estonians, but if theatre activists oriented themselves more fundamentally to German naturalist and realist dramatic art, Young Estonians were more taken with ”theatrical theatre” with its symbolist and impressionist influences. The Young Estonians attended performances at both theatres, ”Vanemuine” and ”Estonia”, and wrote numerous theatre reviews. Yet in the Young Estonia albums (yearbooks and in the magazine Young Estonia, theatre topics have a relatively modest representation. Young Estonians did not have direct

  12. The State, the Museum and the Ethnographer in Constructing National Heritage: Defining Estonian National Costumes in the 1930s

    Directory of Open Access Journals (Sweden)

    Marleen Nõmmela

    2011-03-01

    Full Text Available In this article I attempt to analyse the way in which the Estonian national costume, as heritage, was defined through the cooperation of the state, the museum and ethnographers in the 1930s. The nationalist state wished to strengthen the national identity of Estonia. The Estonian National Museum (ENM as a repository of memory and knowledge availed its resources to support cultural propaganda. The ethnographer Helmi Kurrik, a woman of strong will and keen interest in folk textiles, managed to fulfil her obligation at the expense of her own health. The primary result of her labours was a handbook entitled Eesti rahvarõivad (Estonian Folk Costumes (1938 which has influenced general knowledge of folk costumes in Estonia up to the present day – the ‘right’ national costumes are believed to derive from authentic ethnographical folk costumes held in the Estonian National Museum.

  13. Väärikas Estonian Air jäi kampaaniaga hätta / Alyona Stadnik

    Index Scriptorium Estoniae

    Stadnik, Alyona

    2010-01-01

    Estonian Air müüs veebikaupluse cherry.ee kaudu soodsaid kinkekaarte. Vastuolu tekkis asjaolust, et nõudlus kinkekaartide järele oli suurem kui pakkumine. Lennukompanii katkestas soodsate kinkekaartide müügi

  14. [Encapsulated voices : Estonian sound recordings from the German prisoner-of-war camps in 1916-1918] / Tõnu Tannberg

    Index Scriptorium Estoniae

    Tannberg, Tõnu, 1961-

    2013-01-01

    Arvustus: Encapsulated voices : Estonian sound recordings from the German prisoner-of-war camps in 1916-1918 (Das Baltikum in Geschichte und Gegenwart, 5). Hrsg. von Jaan Ross. Böhlau Verlag. Köln, Weimar und Wien 2012

  15. Estonian Business Schooli magistriharidus nüüd ka koju kätte / Madis Habakuk

    Index Scriptorium Estoniae

    Habakuk, Madis

    2007-01-01

    Sügisest hakkab Estonian Business School koos Mainori Kõrgkooliga pakkuma magistriõpet majandushariduseta inimestele, kus soovijatel on võimalus õppida EBSi Master of Business Administration programmi järgi

  16. Kanada rahastaja tõi Estonian Airi ostu lähemale / Rivo Sarapik ; kommenteerinud Andrus Ansip

    Index Scriptorium Estoniae

    Sarapik, Rivo, 1981-

    2010-01-01

    Estonian Air ja Bombardier sõlmisid lennukite hanke lepingu, tingimused ja hind jäid samaks, muutus vaid lennukite tarneaeg. Ostu rahastab Kanada finantseerimisasutus. Uued lennukid saabuvad Eestisse 2011. a. jaanuaris

  17. Production and application of medical radionuclide: status and urgent problems to be resolved in China

    International Nuclear Information System (INIS)

    Li Mingqi; Deng Qimin; Cheng Zuoyong; Li Maoliang

    2013-01-01

    Radionuclide is the basic of nuclear technology application, it's widely used in manufacturing, medical and other industry area. The status and the problems in radionuclide production and application was introduced, problems in radionuclide production and application of China were also analyzed. The advice was suggested to resolve these problems to promote development of Chinese radionuclide production and application. (authors)

  18. Production of medical radioisotopes in ORNL 86-Inch Cyclotron

    International Nuclear Information System (INIS)

    Skidmore, M.R.

    1975-01-01

    Procedures, targets, and costs are discussed for the production of iodine-123 at the ORNL 86-Inch Cyclotron. The cyclotron is a fixed frequency machine producing 22-MeV proton beams with currents of 3 mA. Flat plate targets are used in the bombardment of readily fabricated metals when highest production rates are necessary, while capsule targets are used when flat plate coatings are difficult or when high production rates are not required. Window targets with metal foils or powders, inorganic compounds, or isotopically enriched materials are also used. (PMA)

  19. The role of electromagnetic separators in the production of radiotracers for bio-medical research and nuclear medical application

    International Nuclear Information System (INIS)

    Beyer, Gerd J.; Ruth, Thomas J.

    2003-01-01

    With the growing complexity of positron emission tomography/single photon emission computed tomography imaging and the new developments in systemic radionuclide therapy there is a growing need for radioisotope preparations with higher radiochemical and radionuclidic purity that has not been achievable before. Especially important for the new applications is the specific activity of the radiotracer. Conventional methods in medical isotope production have reached their technical limitations. The role of isotope separators is discussed with examples of typical production and characterization experiments conducted at the ISOLDE and TRIUMF facilities. These preliminary experiments indicate that isotope separators have a definite role to play in the future for the production of radioisotopes for biomedical research and medical application

  20. The role of electromagnetic separators in the production of radiotracers for bio-medical research and nuclear medical application

    CERN Document Server

    Beyer, Gerd-Jürgen

    2003-01-01

    With the growing complexity of positron emission tomography/single photon emission computed tomography imaging and the new developments in systemic radionuclide therapy there is a growing need for radioisotope preparations with higher radiochemical and radionuclidic purity that has not been achievable before. Especially important for the new applications is the specific activity of the radiotracer. Conventional methods in medical isotope production have reached their technical limitations. The role of isotope separators is discussed with examples of typical production and characterization experiments conducted at the ISOLDE and TRIUMF facilities. These preliminary experiments indicate that isotope separators have a definite role to play in the future for the production of radioisotopes for biomedical research and medical application.

  1. The role of electromagnetic separators in the production of radiotracers for bio-medical research and nuclear medical application

    Science.gov (United States)

    Beyer, Gerd J.; Ruth, Thomas J.

    2003-05-01

    With the growing complexity of positron emission tomography/single photon emission computed tomography imaging and the new developments in systemic radionuclide therapy there is a growing need for radioisotope preparations with higher radiochemical and radionuclidic purity that has not been achievable before. Especially important for the new applications is the specific activity of the radiotracer. Conventional methods in medical isotope production have reached their technical limitations. The role of isotope separators is discussed with examples of typical production and characterization experiments conducted at the ISOLDE and TRIUMF facilities. These preliminary experiments indicate that isotope separators have a definite role to play in the future for the production of radioisotopes for biomedical research and medical application.

  2. Preservatives in Personal Hygiene and Cosmetic Products, Topical Medications, and Household Cleaners in Spain.

    Science.gov (United States)

    Pastor-Nieto, María Antonia; Alcántara-Nicolás, Francisco; Melgar-Molero, Virginia; Pérez-Mesonero, Raquel; Vergara-Sánchez, Aránzazu; Martín-Fuentes, Adriana; González-Muñoz, Patricia; de Eusebio-Murillo, Ester

    2017-10-01

    Preservatives are added to cosmetic, household cleaning, and other industrial products to prevent the growth of microorganisms. Unfortunately, exposure to these substances can cause sensitization. Between January and June 2015, we analyzed the ingredients of 2300 products commercially available in Spain to identify the frequency of a wide variety of preservatives in different product categories. We analyzed 1093 skin care and cosmetic products sold exclusively in pharmacies (dermocosmetics), 458 household cleaning and personal hygiene and cosmetic products sold in supermarkets, 636 topical medications, and 113 cosmetic products sold in a herbal shop. Phenoxyethanol, citric acid, sodium benzoate, and potassium sorbate were very common in all the cosmetic product categories. Parabens were present in 16.1% of dermocosmetic products, 14.45% of cosmetic products available in supermarkets, 0.88% of cosmetic products available in the herbal shop, 5.18% of topical medications, and in none of the cleaning products. Isothiazolinones were identified in 2.56% of dermocosmetic products, 18% of cosmetic products in supermarkets, 7.9% of cosmetic products in the herbal shop, 63.63% of household cleaners, and in none of the topical medications. Formaldehyde releasers were detected in 5.76% of dermocosmetic products, 6.42% of cosmetic products sold in supermarkets, 7.96% of cosmetic products sold in the herbal shop, 3.93% of topical medications, and 16.74% of household cleaners. Evaluation of the presence of preservatives in everyday products allows us to indirectly estimate exposure levels to each one. Measures restricting the use of the most problematic preservatives need to be strengthened. Copyright © 2017 AEDV. Publicado por Elsevier España, S.L.U. All rights reserved.

  3. The Navy Medical Technology Watch: Hemostatic Dressing Products for the Battlefield

    National Research Council Canada - National Science Library

    Snow, Carl; Olson, Cheryl; Melcer, Ted

    2006-01-01

    ... research evidence on these products or methods. The Medical Modeling, Simulation and Mission Support program at Naval Health Research Center initiated a "Tech Watch" project to investigate current and developing technologies for hemostatic...

  4. Is the European medical products authorization regulation equipped to cope with the challenges of nanomedicines?

    NARCIS (Netherlands)

    Dorbeck-Jung, Barbel R.; Chowdhury, Nupur; Chowdhury, Nupur

    2011-01-01

    This article analyses the emerging European regulatory activities in relation to nanopharmaceuticals. The central question is whether the regulatory responses are appropriate to cope with the regulatory problems nanomedicinal development is posing. The article explores whether the medical product

  5. The Effects of Stimulant Medications on the Art Products of ADHD Children.

    Science.gov (United States)

    Epperson, Julie; Valum, J. Lane

    1992-01-01

    Investigated effects of varying doses of psychostimulant medications on expressive qualities evident in children's art products. Findings from eight children affected by attention-deficit hyperactivity disorder indicated that specific areas assessed were influenced by varying doses of medications. Data from art corresponded in positive manner to…

  6. The Supply of Medical Radioisotopes. Market impacts of converting to low-enriched uranium targets for medical isotope production

    International Nuclear Information System (INIS)

    Westmacott, Chad; Cameron, Ron

    2012-01-01

    The reliable supply of molybdenum-99 ( 99 Mo) and its decay product, technetium-99m ( 99m Tc), is a vital component of modern medical diagnostic practices. At present, most of the global production of 99 Mo is from highly enriched uranium (HEU) targets. However, all major 99 Mo-producing countries have recently agreed to convert to using low-enriched uranium (LEU) targets to advance important non-proliferation goals, a decision that will have implications for the global supply chain of 99 Mo/ 99m Tc and the long-term supply reliability of these medical isotopes. This study provides the findings and analysis from an extensive examination of the 99 Mo/ 99m Tc supply chain by the OECD/NEA High-level Group on the Security of Supply of Medical Radioisotopes (HLG-MR). It presents a comprehensive evaluation of the potential impacts of converting to the use of LEU targets for 99 Mo production on the global 99 Mo/ 99m Tc market in terms of costs and available production capacity, and the corresponding implications for long-term supply reliability. In this context, the study also briefly discusses the need for policy action by governments in their efforts to ensure a stable and secure long-term supply of 99 Mo/ 99m Tc

  7. New technologies for production of radiopharmaceuticals and other medical preparations

    International Nuclear Information System (INIS)

    Bazaniak, Z.; Iller, E.; Mikolajczak, R.

    2004-01-01

    The Radioisotope Centre POLATOM belongs to the group of R and D institutions whose profile of activities comprises, besides applied research work, also manufacturing of a range of products based on implementation of the Centre's own developments. The Centre possesses considerable experience in its area of expertise: forty-six years of manufacturing of various radiation sources and radiopharmaceuticals, performing metrology and analysis of radioactive materials, which makes OBRI a unique R and D unit. The Centre is a chief manufacturer supplier of radiopharmaceuticals for nuclear medicine in Poland, and also an active exporter with a market of several tens countries. The current trends in the Centre activity assume combination of R and D work with practical application of its results for production purposes. The undertaken research topics are studied in co-operation with domestic and foreign scientific institutions. (author)

  8. Cannabis cultivation: Methodological issues for obtaining medical-grade product.

    Science.gov (United States)

    Chandra, Suman; Lata, Hemant; ElSohly, Mahmoud A; Walker, Larry A; Potter, David

    2017-05-01

    As studies continue to reveal favorable findings for the use of cannabidiol in the management of childhood epilepsy syndromes and other disorders, best practices for the large-scale production of Cannabis are needed for timely product development and research purposes. The processes of two institutions with extensive experience in producing large-scale cannabidiol chemotype Cannabis crops-GW Pharmaceuticals and the University of Mississippi-are described, including breeding, indoor and outdoor growing, harvesting, and extraction methods. Such practices have yielded desirable outcomes in Cannabis breeding and production: GW Pharmaceuticals has a collection of chemotypes dominant in any one of eight cannabinoids, two of which-cannabidiol and cannabidivarin-are supporting epilepsy clinical trial research, whereas in addition to a germplasm bank of high-THC, high-CBD, and intermediate type cannabis varieties, the team at University of Mississippi has established an in vitro propagation protocol for cannabis with no detectable variations in morphologic, physiologic, biochemical, and genetic profiles as compared to the mother plants. Improvements in phytocannabinoid yields and growing efficiency are expected as research continues at these institutions. This article is part of a Special Issue entitled "Cannabinoids and Epilepsy". Copyright © 2016. Published by Elsevier Inc.

  9. Successes and problems in the development of medical radioisotope production in Russia

    Science.gov (United States)

    Zhuikov, B. L.

    2016-05-01

    There are many challenges that face radionuclide production and application for medical diagnostics and therapy in Russia. In this article, the development of novel production methods for medical radionuclides (82Sr, 82Sr/82Rb-generator, 117mSn, 225Ac, etc.) at the Institute for Nuclear Research, RAS is described, providing an example of how supporting basic nuclear facilities, backing fundamental research, granting scientists and medical specialists freedom in choosing a research area, and effective international collaboration involving developed countries combine to enable progress in the field.

  10. Clinical Space Medicine Products as Developed by the Medical Operations Support Team (MOST)

    Science.gov (United States)

    Polk, James D.; Doerr, Harold K.; Hurst, Victor W., IV; Schmid, Josef

    2007-01-01

    Medical Operations Support Team (MOST) is introducing/integrating teaching practices associated with high fidelity human patient simulation into the NASA culture, in particular, into medical training sessions and medical procedure evaluations. Current/Future Products iclude: a) Development of Sub-optimal Airway Protocols for the International Space Station (ISS) using the ILMA; b) Clinical Core Competency Training for NASA Flight Surgeons (FS); c) Post-Soyuz Landing Clinical Training for NASA FS; d) Experimental Integrated Training for Astronaut Crew Medical Officers and NASA FS; and e) Private Clinical Refresher Training.

  11. [Medication errors in anaesthesia: a review of reports from the French Health Products Agency].

    Science.gov (United States)

    Rivière, A; Piriou, V; Durand, D; Arnoux, A; Castot-Villepelet, A

    2012-01-01

    The purpose of this study was to assess medication errors and risks of medication errors during anaesthetic practice reported at the French Health Products Agency (Afssaps) from 2005 to 2010. Descriptive study. The data are issued of "Medication errors and risks of medication errors" file which group together all cases received by the Medication Errors Unit at Afssaps since 2005. A total of 263 cases were observed by the Medication Errors Unit at Afssaps. Among them, 159 cases were risks of medication errors, 76 cases were patent medication errors and 28 were near misses. Among the 76 cases of patent medication errors, out of which 47 cases were appreciated with adverse reaction and 35 cases were classified as serious. Adverse events were classified as haemodynamic, respiratory and neurologic events. Most of the errors occurred during administration (65%), followed by dispensing errors (14%), storage errors (15%) or preparation errors (4%). Sixty-nine percent of cases of wrong drug errors were found, followed by 26% of errors of strength, 3% of incorrect route of administration errors and 2% of patient errors. In most of cases, similarity in packaging was underlined (n=83). This study showed that the majority of medication errors and risks of medication errors during anaesthetic practice, underline similarity in packaging. Results highlighted the importance of vial labeling presentation (readability and mention understanding) in anaesthetic practice. Copyright © 2011. Published by Elsevier SAS.

  12. Automatic radioisotope production devices adapted to a medical cyclotron

    International Nuclear Information System (INIS)

    Crouzel, C.; Le Poec, C.; Jarry, E.; Knipper, R.; Comar, D.

    1979-01-01

    The authors describe an irradiation device set up beside a compact medical cyclotron (520.CGR-MeV cyclotron). The variable energy machine can accelerate 3-22 MeV protons, 3-13 MeV deuterons, 6-26 MeV alpha particles and 5-31 MeV helium-3 particles, the currents extracted at the maximum energies reaching 50 μA for 4 He and 3 He, 70 μA for protons and deuterons. The essential characteristics demanded of the apparatus in order to produce a regular and abundant supply of short-lived radioisotopes were as follows: - Flexibility of use or the possibility of fast, completely non-manual target changing. - Simplicity of operation: the target-holder components must be easily interchangeable and the transfer of radioisotopes from the irradiation point to the chemical laboratory must be rapid. - Working safety: the automatic target-holder cooling controls must be duplicated by manual controls. - Target cooling efficiency: these targets, whether gaseous, liquid or solid, must be able to support a high particle current. (Auth.)

  13. Production of medically useful nitric monoxide using AC arc discharge.

    Science.gov (United States)

    Li, S R; Huang, Y F; Liu, Z; Sui, M H; Liu, J M; Yan, K P

    2018-02-28

    Inhaled nitric monoxide (iNO) is increasingly used as a medical treatment for acute respiratory distress syndrome. A course of the existing nitric monoxide (NO) therapy with gas cylinders could cost up to approximately $15,000 for an average of 30.2 h. Moreover, a gas cylinder containing a mixture of N 2 and NO may potentially leak NO. The objective of this study is to develop an efficient and cost-effective on-site iNO generation system. In the present setup, NO was generated by using dry air or mixed oxygen/nitrogen (O 2 /N 2 ) and an AC power source with an output power level of 5-30 W at atmospheric pressure. The simultaneously produced NO 2 was eliminated with an ammonium sulfite ((NH 4 ) 2 SO 3 ) solution. The effects of the O 2 /N 2 ratio, gas flow rate, discharge gap distance, output energy density and electrode structure on NO x concentration and the NO/NO 2 ratio are reported. The concentrations of NO and NO 2 reached 62 ppm and 3 ppm, respectively, after absorption and dilution at a gas flow rate of 6 L/min. With the present setup, the AC arc discharge produced NO x at a stable concentration for at least 6 h using dry air. Copyright © 2017 Elsevier Inc. All rights reserved.

  14. The results of medical surveillance of beryllium production personnel

    International Nuclear Information System (INIS)

    Koviazin, A.; Urikh, A.; Kovianzina, L.

    2004-01-01

    The report presents results of surveillance of 1836 workers of beryllium production of Ulba Metallurgical Plant JSC with the acute and chronic forms of occupation diseases for 52 years of its operation. The dependence of acute and chronic occupation lesions on the protection degree is shown. It has been found out that, the risk of getting an occupation disease increases sharply at the moments of experimental works and at the time of reconstruction and some other extreme conditions in the production, that is supported by fixed lesions of eye mucous coat, skin and lung lesions. In this case, the readiness of people for their work in deleterious conditions and their personal responsibility for following the regulations of safety occupational standards plays a definite role. Therefore, the issues of protection are of paramount importance in prophylaxis both of acute and chronic exposure to beryllium. An influence of duration of service and occupation on chronic beryllium diseases is shown. A parallel between the lung beryllium disease and skin lesions by insoluble beryllium compounds is drawn for the first time. (author)

  15. Eesti patsient. Haiguse ja haige inimese kujutamise mudel 19. sajandi eesti kultuuris ja kirjasõnas. The Estonian Patient: A Model for the Representation of Illness and the Ill in 19th Century Estonian Culture and Letters

    Directory of Open Access Journals (Sweden)

    Janek Kraavi

    2012-04-01

    Full Text Available The portrait of the 18th and 19th century „Estonian patient” sketched in this article is a theoretical model of the ill person, based mainly on literary texts, but with reference to a variety of scientific and popular-scientific material. The point of departure is the classic postcolonial theorist, Frantz Fanon, in whose writings medicine, healing, and discourse on such topics are seen as the functioning of a specific colonial practice. The most notable characteristic of the figure of the Estonian patient is non-communicativeness. Communication is avoided and feared primarily because it has to be directed toward those in higher positions of power, or to institutions that embody power (the apothecary, the hospital. While these traits also characterize the separation between peasants and their rulers more generally, in a situation of illness the exclusion is felt with a double intensity. Sickness casts the peasant in a double bind: when in need of help or healing, contact across the divide between social rank, and – more broadly, between two cultures and ways of understanding the world, becomes unavoidable. In such situations, illness signifies an intensification of the gap in social standing. The ill person, who already stands on a lower rung of the social hierarchy, becomes all the more marginalized. In keeping with these observations, the real reason behind indecisiveness and refusal of medical treatment may well be an effort to avoid or postpone humiliation on the basis of lower social standing. Other contributing factors might include unconscious resistance – or even a conscious model of resistance – in the psyche, which manifests as an avoidance of communication. The content and motivating force for the model is not heroism, but rather a sense of shame. Indeed, behind the context of medical culture lurks ethnic and material isolation. The individual’s economic situation, living conditions, education and – most important – his

  16. Adoption of Falsified Medical Products in a Low-Income Country : Empirical Evidence for Suriname

    NARCIS (Netherlands)

    Ph.H.B.F. Franses (Philip Hans); M.M. Lede (Madesta)

    2017-01-01

    markdownabstractBased on detailed shipping figures for Suriname’s main harbour in Paramaribo, we estimate the total shipments (in kilograms) of original and falsified medical products for 1996–2008 across five product categories. Using various time series techniques and diffusion models, we document

  17. The Estonian national program for sustainable resource development and its connection with teaching about fossil fuels in chemistry courses

    International Nuclear Information System (INIS)

    Karik, H.

    1996-01-01

    The conception of sustainable resource development worked out under the initiative of the United Nations (UN) actualizes ideas for improving the health of people and the environment. The needs of people are to he addressed and, simultaneously, natural resources preserved. That is ,why ecological and economic expenses are to he integrated and flow sheets of industrial plants are to be reorganized in order to utilize natural resources in a rational way. The association of Estonia with the resolution of the UN Conference on Environmental Development held in Rio de Janeiro and the resolution of the Estonian Parliament concerning The National Program of Sustainable Development require changes in our lifestyle. Chemical education in schools has to support a change in the way of thinking and many concrete subjects can be connected with the problems of sustainable development. Metallic elements get into the environment mostly with fuel combustion ashes. According to various prognoses, fossil fuel resources will last for a thousand years. This means that more and more metallic compounds are thrown into the environment. Dispersion of metals in the air, water bodies and soil is continuously increasing. Finally, they reach the food chain and to the human body. As a result, toxicosis, illnesses, and inadvisable dislocations in organic life may occur. The trend to use ash as a raw material for metal production is considered to have some prospective economically attractive application. This would be one possible way of sustainable resource development to avoid the increase of environmental pollution and increase production of the corresponding metals

  18. Strategies for Estonian rural family enterprises. Eesti maapiirkonna pereettevõtete strateegia

    Directory of Open Access Journals (Sweden)

    Maret Kirsipuu

    2013-01-01

    Full Text Available The paper seeks to analyse family businesses in rural areas, family business strategies and re-registration of sole proprietors with the Centre of Registers and Information Systems (hereinafter Commercial Register in 2009, and to provide an overview of entrepreneurship policies targeted at Estonian rural businesses. Layoffs have increased the number of unemployed; some of those who have lost employment opt for social assistance benefits, but some others decide to become entrepreneurs. Many enterprising people in Estonia have set up a family enterprise, mainly in the sphere of services, agriculture and tourism. The Estonian entrepreneurship policy supports enterprising people and approves of entrepreneurship as a promoter of national economic development. One of the most positive qualities of family enterprises is their short decision-making chain, which ensures rapid implementation of the strategy.

  19. The Role of Language in (Recreating Tatar Diaspora Identity: The Case of the Estonian Tatars

    Directory of Open Access Journals (Sweden)

    Maarja Klaas

    2015-06-01

    Full Text Available This paper focuses on the meanings assigned to Tatar language among the Tatar diaspora in Estonia. According to interviews with Estonian Tatars as well as descriptions of field material from Tatarstan, language is an important aspect of Tatar ethnic identity. This paper will track common discourses about the Tatar language and the way it is connected to Tatar ethnic identity. Issues concerning Tatar language are used to demonstrate various ways of enacting Tatarness in Estonia. It is shown that Estonian Tatars worry about the vitality and purity of Tatar language, but for some, marginalization of dialects is also an issue. People categorized with the same identity labels by self and others can experience and enact their Tatarness in a variety of different ways.

  20. Real-time Stack Monitoring at the BaTek Medical Isotope Production Facility

    Energy Technology Data Exchange (ETDEWEB)

    McIntyre, Justin I.; Agusbudiman, A.; Cameron, Ian M.; Dumais, Johannes R.; Eslinger, Paul W.; Gheddou, A.; Khrustalev, Kirill; Marsoem, Pujadi; Miley, Harry S.; Nikkinen, Mika; Prinke, Amanda M.; Ripplinger, Mike D.; Schrom, Brian T.; Sliger, William A.; Stoehlker, Ulrich; Suhariyono, G.; Warren, Glen A.; Widodo, Susilo; Woods, Vincent T.

    2016-04-01

    Radioxenon emissions from radiopharmaceutical production are a major source of background concentrations affecting the radioxenon detection systems of the International Monitoring System (IMS). Collection of real-time emissions data from production facilities makes it possible to screen out some medical isotope signatures from the IMS radioxenon data sets. This paper describes an effort to obtain and analyze real-time stack emissions data with the design, construction and installation of a small stack monitoring system developed by a joint CTBTO-IDC, BATAN, and PNNL team at the BaTek medical isotope production facility near Jakarta, Indonesia.

  1. Market Opportunities for Automotive Components Used in Non-automotive Applications Manufacturing : Estonian Industrial Market

    OpenAIRE

    Kalajärv, Jaana

    2012-01-01

    This thesis examines the opportunities available for automotive components in the Esto-nian non-automotive industrial market. The literature review part is mainly covers the theory of marketing research, because of the approach chosen for this paper. Only small part of marketing research process is re-searched closer in literature review section, because of the scope of the research. Three most relevant steps for the thesis are chosen from research process for further more in-vestigation,...

  2. Short outlines of books by Estonian authors : [annotations] / Rutt Hinrikus, Janika Kronberg

    Index Scriptorium Estoniae

    Hinrikus, Rutt, 1946-

    1998-01-01

    Laretei, Käbi. Eksiil; Toona, Elin. Lotukata; Park, Eeva. Naeru õpilane; Luik, Viivi. Inimese kapike; Laaman, Ilona. Vesi ahjus; Viiding, Juhan (Üdi, Jüri). Kogutud luuletused; Paju, Juhan. Katkenud romaan; Paju, Juhan. Hõõguv rist; Estonian short stories / toim. Kajar Pruul ja Darlene Reddaway; Traat, Mats. Kartaago kiirrong; Kauksi Ülle. Säng; Kross, Jaan. Paigallend; Puhvel, Madli. Symbol of dawn; Kaplinski, Jaan. Võimaluste võimalikkus; Kaplinski, Jaan. Usk on uskmatus

  3. Serological evidence of exposure to globally relevant zoonotic parasites in the Estonian population

    DEFF Research Database (Denmark)

    Lassen, Brian; Janson, Marilin; Viltrop, Arvo

    2016-01-01

    We investigated Estonian population and its selected subgroups for serological evidence of exposure to Ascaris lumbricoides, Echinococcus spp., Taenia solium, Toxocara canis, Toxoplasma gondii, and Trichinella spiralis. Serum samples from 999 adults representing general population, 248 children...... spp. seroprevalence was higher in children. By contrast, T. gondii seroprevalence was higher in animal caretakers, and lower in children, than in the general population. In the general population, the WB-confirmed Echinococcus spp. seroprevalence was 0.5%, T. solium cysticercosis seroprevalence was 0...

  4. Radioisotope production for medical and non-medical application at the Nuclear Energy Unit (UTN)

    International Nuclear Information System (INIS)

    Mohamad Awang; Zulkifli Mohamad Hashim; Yusof Azuddin Ali

    1986-01-01

    Radioisotopes are produced by using a low power research reactor, TRIGA MARK II situated at UTN. Products intended for use as radiopharmaceuticals undergo a more stringent precaution. The solvent extraction technique used to separate 99 m TC from the radioactive solution of Potassium molybdate (K 2 99 Mo0 4 ) is explained in detail. The specific activity of 99Mo obtained at a neutron flux of 2.5 x 10 12 n/cm 2 , s ranges from 1.75 mCi 99 Mo/g MoO 3 to 6.25 mCi 99 Mo/g MoO 3 . However, the specific activity of 99 Mo obtained could be increased by a factor of 6 using the central thimble facility. There are 14 radioisotopes being currently produced. Commonly used cold kits for 99m TC labelling are also produced. Sn-MDP kit for bone scintigraphy is prepared under aseptic environment and freeze-drived. Products are terminally sterilized using γ-irradiation. Uptake studies done on laboratory animals indicate good bone uptake. A few radioisotopes and radiopharmaceuticals products to be produced by UTN in future are reviewed. (author)

  5. Production of 123 I for medical diagnosis application

    International Nuclear Information System (INIS)

    Britto, J.L.Q. de.

    1982-01-01

    A method for production of carrier free 123 I with high radionuclidic purity in which the processing is done remotely was developed at Instituto de Engenharia Nuclear in Rio de Janeiro. The 123 I is produced in the decay of 123 Xe which is obtained through the reaction 122 Te ( 3 He, 2 n) 123 Xe with 30 MeV 3 He beams of IEN's variable energy cyclotron. The irradiated natural Te O 2 target is heated in a furnace at 675 0 C and the diffused out 123 Xe is adsorbed in a copper trap maintained at -196 0 C. The 123 Xe is allowed to decay during 6.3 hours and the 123 I produced washed out of the trap with a 0.1 N solution of NaOH. All the process is remotely controlled by using electric and pneumatic systems as well as manipulators and tongs. The quality control was achieved by atomic absorption and gamma-ray spectroscopy. (author)

  6. Level of knowledge and sources of information about the rheumatoid arthritis in Estonian patients.

    Science.gov (United States)

    Põlluste, Kaja; Kallikorm, Riina; Lember, Margus

    2014-05-01

    The objective of this paper was to find out how many patients with rheumatoid arthritis (RA) know about several aspects of disease, to explain the associations between the level of self-rated knowledge and patients' background and health status and to compare the importance of the main sources of information. A random sample (n = 1,259) of adult Estonian RA patients was selected from the Estonian Health Insurance Fund Database. The patients completed a self-administered questionnaire, which included information about their socio-demographic and disease characteristics, use of health services, information about the disease, and sources of information. Regression analysis was used to calculate the associations between the independent variables and level of self-rated knowledge about several aspects of RA. The results of the study indicated that the self-reported ratings of knowledge about the disease in Estonian RA patients were rather low. Health professionals were mentioned as the primary sources of information, but the longer disease history and more frequent use of health services as considerable predictors of higher ratings of knowledge refer to role of personal experience in obtaining knowledge about the disease as well.

  7. Cancer incidence and thyroid disease among Estonian Chernobyl clean-up workers

    International Nuclear Information System (INIS)

    Auvinen, A.; Salomaa, S.; Boice, J.D. Jr.

    1998-09-01

    The report describes the development and summarizes the results of the project Cancer incidence and thyroid disease among Estonian Chernobyl clean-up workers. One of the goals of the report is to give research protocols and questionnaires for researchers involved in other studies. Eight previously published articles are also included summarizing the results. The development of the collaboration work of the project is described in the introduction of the report. Epidemiological methods are described in an article complemented by the protocol and English version of the questionnaire administered to all cleanup workers, as well as the data collection form of the thyroid study. The results from biological biodosimetry using both glycophorin A and FISH methods have shown that the radiation doses received by the Chernobyl cleanup workers were relatively low. Thyroid nodularity was not associated with any radiation exposure characteristic in the thyroid screening study. Estonian Chernobyl cleanup workers were followed up for cancer incidence through the Estonian Cancer Registry. No cases of leukemia or thyroid cancer were observed by the end of 1993. It is too early to observe possible effect on other types of cancer. However, mortality from suicides was increased compared with general population. Further follow-up and the extension to other Baltic countries in the future will undoubtedly strengthen the study. There are also plans for future projects covering areas from psychosocial factors to radiation biology

  8. Medical use of cannabis products: Lessons to be learned from Israel and Canada.

    Science.gov (United States)

    Ablin, J; Ste-Marie, P A; Schäfer, M; Häuser, W; Fitzcharles, M-A

    2016-02-01

    The German government intends to reduce the barriers for the medical use of cannabis products. A discussion on the indications and contraindications of the medical use of cannabis and on the changes of the regulatory framework has already begun in Germany. It is useful to draw from the experiences of other countries with a more liberal medical use of cannabis. The Israeli and Canadian experience is outlined by physicians who have been charged with expertise on the medical use of cannabis by their jurisdiction. In Israel, only the plant-based cannabinoid nabiximol (mixture of tetrahydrocannabinol/cannabidiol) can be prescribed for spasticity/chronic pain in multiple sclerosis and for cancer pain. The costs of nabiximole are reimbursed by some, but not by all health maintenance organizations. The medical use of marijuana is permitted; however, it is strictly regulated by the government. Selected companies are allowed to produce marijuana for medical use, and only certain physicians are licensed to prescribe marijuana as a therapeutic drug for specific indications such as chronic neuropathic, and cancer pain, inflammatory bowel diseases, or posttraumatic stress disorder if conventional treatments have failed. The costs of marijuana are not reimbursed by health insurance companies. In Canada, synthetic cannabinoids and the plant-based (nabiximol) are licensed for neuropathic and cancer pain, HIV-related anorexia and chemotherapy-associate nausea. The costs of these synthetic cannabinoids are covered by health insurance companies. The medical use of marijuana as a treatment option is allowed for individual patients suffering from any medical condition when authorized by a medical practitioner or nurse. Licensed producers are the only source for patients to newly access medical cannabis, although those with previous permission to grow may continue cultivation at the present time. The costs of marijuana are not reimbursed by health insurance companies. There are multiple

  9. Field trial on glucose-induced insulin and metabolite responses in Estonian Holstein and Estonian Red dairy cows in two herds

    Directory of Open Access Journals (Sweden)

    Kaart Tanel

    2010-01-01

    Full Text Available Abstract Background Insulin secretion and tissue sensitivity to insulin is considered to be one of the factors controlling lipid metabolism post partum. The objective of this study was to compare glucose-induced blood insulin and metabolite responses in Estonian Holstein (EH, n = 14 and Estonian Red (ER, n = 14 cows. Methods The study was carried out using the glucose tolerance test (GTT performed at 31 ± 1.9 days post partum during negative energy balance. Blood samples were obtained at -15, -5, 5, 10, 20, 30, 40, 50 and 60 min relative to infusion of 0.15 g/kg BW glucose and analysed for glucose, insulin, triglycerides (TG, non-esterified fatty acids (NEFA, cholesterol and β-hydroxybutyrate (BHB. Applying the MIXED Procedure with the SAS System the basal concentration of cholesterol, and basal concentration and concentrations at post-infusion time points for other metabolites, area under the curve (AUC for glucose and insulin, clearance rate (CR for glucose, and maximum increase from basal concentration for glucose and insulin were compared between breeds. Results There was a breed effect on blood NEFA (P P P P P P th min nadir (P th min postinfusion (P Conclusion Our results imply that glucose-induced changes in insulin concentration and metabolite responses to insulin differ between EH and ER dairy cows.

  10. Computation of Estonian CORS data using Bernese 5.2 and Gipsy 6.4 softwares

    Science.gov (United States)

    Kollo, Karin; Kall, Tarmo; Liibusk, Aive

    2017-04-01

    GNSS permanent station network in Estonia (ESTREF) was established already in 2007. In 2014-15 extensive reconstruction of ESTREF was carried out, including the establishment of 18 new stations, change of the hardware in CORS stations as well as establishing GNSS-RTK service for the whole Estonia. For GNSS-RTK service one needs precise coordinates in well-defined reference frame, i.e., ETRS89. For long time stability of stations and time-series analysis the re-processing of Estonian CORS data is ongoing. We re-process data from 2007 until 2015 with program Bernese GNSS 5.2 (Dach, 2015). For the set of ESTREF stations established in 2007, we perform as well computations with GIPSY 6.4 software (Ries et al., 2015). In the computations daily GPS-only solution was used. For precise orbits, final products from CODE (CODE analysis centre at the Astronomical Institute of the University of Bern) and JPL (Jet Propulsion Laboratory) for Bernese and GIPSY solutions were used, respectively. The cut-off angle was set to 10 degrees in order to avoid near-field multipath influence. In GIPSY, precise point positioning method with fixing ambiguities was used. Bernese calculations were performed based on double difference processing. Antenna phase centers were modelled based on igs08.atx and epnc_08.atx files. Vienna mapping function was used for mapping tropospheric delays. For the GIPSY solution, the higher order ionospheric term was modelled based on IRI-2012b model. For the Bernese solution higher order ionospheric term was neglected. FES2004 ocean tide loading model was used for the both computation strategies. As a result, two solutions using different scientific GNSS computation programs were obtained. The results from Bernese and GIPSY solutions were compared, using station repeatability values, RMS and coordinate differences. KEYWORDS: GNSS reference station network, Bernese GNSS 5.2, Gipsy 6.4, Estonia. References: Dach, R., S. Lutz, P. Walser, P. Fridez (Eds); 2015

  11. Eesti antiigitõlke traditsioonid / Traditions of Estonian Translation from Ancient Greek and Latin

    Directory of Open Access Journals (Sweden)

    Janika Päll

    2012-06-01

    Full Text Available The tradition of translating ancient Greek and Roman authors into Estonian is short, beginning with first attempts at the end of the 18 th century and the close adaptations of two Anacreontic poems (21 and 24 by the first Estonian poet Kristjan Jaak Peterson (in 1818, which remained in manuscript for a long time. The continuous history of printed translations began in 1878 with the translations from Homer by Jaan Bergmann. At present, a new, extensive and regularly updated bibliography with a database of earlier translations is being created (EAB 2012, which also includes the translations in the journals and more extensive citations in articles, as printing separate books with ancient literature started very late (1908 and was very rare in the beginning.  The periods in Estonian translation reflect the history of the country. Almost every period has its own specific trends, beginning with the focus on Greek and the role of periodicals in the first, resembling the patchwork-model of translation that has been described by Karl Eimermacher. Alongside the wish to entertain and educate, we see a strong tendency to use these translations for the development of Estonian national identity by comparing the Estonian epic “Kalevipoeg” to Homer’s epics and translating pieces from Tacitus’ “Germania” as early references to Estonia and thereby extending Estonia’s written history.  The 1920s and 1930s bring first attempts to create a canon, with a stress on Latin and the translations made for school, as well as the development of verse translation. However, all this was disrupted by the almost total abandonment of the classical tradition during the war and the Stalinist period. The comeback in the 1960s brought the translation of central authors from the classical canon (Homer, Vergil, Sophocles, supported by other activities of canon-building (anticipated partly in the 1920s and 1930s: the composition of anthologies and histories of literature

  12. LLNL medical and industrial laser isotope separation: large volume, low cost production through advanced laser technologies

    International Nuclear Information System (INIS)

    Comaskey, B.; Scheibner, K. F.; Shaw, M.; Wilder, J.

    1998-01-01

    The goal of this LDRD project was to demonstrate the technical and economical feasibility of applying laser isotope separation technology to the commercial enrichment (>lkg/y) of stable isotopes. A successful demonstration would well position the laboratory to make a credible case for the creation of an ongoing medical and industrial isotope production and development program at LLNL. Such a program would establish LLNL as a center for advanced medical isotope production, successfully leveraging previous LLNL Research and Development hardware, facilities, and knowledge

  13. Exports of company: SWOT-analysis, product strategy and sales targets

    International Nuclear Information System (INIS)

    Hammer, Hele

    1998-01-01

    Despite its smallness Estonia has a good chance to enjoy a success in the international peat market, due to the favourable geographical location and well developed peat industry. There are numerous harbours, low wages and salaries, and a good educational background in Estonia. Moreover, Estonian economy is aiming at a competitive market economy. Peat exports represent a great opportunity to improve the balance of payments, create jobs, support the State through the taxes paid, meet the needs of foreign customers, earn a profit for Estonian peat companies and better Estonian standard of living. When preparing this paper, marketing textbooks and professional articles of interest were used. The working experience of one of Estonian peat companies and acquired practical knowledge have also been of help throughout the thesis. In general, it may be expected that Estonian peat exports will increase in the next few years. The Netherlands and Germany will remain the main target countries, also France, Belgium and the United Kingdom are important. The exports to Italy will, for sure, increase, to the Middle-East these will be quite likely. The Far East is also a potential market, especially Korea and Japan. Peat marketing is based on the following premises: the demand for peat is a derived demand, being dependent on that for the end-products. The number of customers is small and their decisions are rational. Estonian peat producers also have to face the fact that the production needs to be marketed mostly abroad. While considering the product strategy, the conclusion was that with peat the least cost strategy is easily applicable. Possibilities for differentiation are almost next to nothing (except in case of packaging or transportation services). Possibilities will widen when the production of potting soils is launched. Most Estonian peat firms sell peat and products thereof through foreign wholesalers, some of them render also transportation services and this is well

  14. Recognizing Potential Buprenorphine Medication Misuse: Product Packaging Does Not Degrade With Laundering.

    Science.gov (United States)

    Gunderson, Erik W

    2015-01-01

    Expanded office-based buprenorphine opioid dependence treatment is associated with medication misuse and diversion consequences. Recurrent early refill requests may indicate misuse or diversion, although further research is needed on how to effectively recognize and address the issue in clinical practice. In the current study, patient report of damaged medication from laundering prompted evaluation of laundering on degradation of buprenorphine-containing product packages and contents. Four buprenorphine product packaging approaches were assessed: 3 buprenorphine/naloxone placebo demonstration products (Suboxone and Bunavail film in foil wrappers and Zubsolv tablet in a blister pack) and Rexam-manufactured Screw-Loc closure pill container filled with a chewable aspirin as a surrogate for generic buprenorphine and buprenorphine/naloxone products. Two experimental laundering conditions, wash machine alone (W) and washer/dryer (W+D), were compared with unlaundered control (C) condition. Standard laundering settings were based on patient presentation. Products from the 2 experimental conditions and the control condition were labeled A, B, or C with counterbalanced assignment prior to visual examination of packaging and contents by the investigator who was blinded to condition. Packaging and contents remained intact for all products across experimental conditions, with only minor cosmetic effects compared with control. The W+D Suboxone film had 1-2 mm curling of the wrapper corners. Zubsolv blister packs had slight paper label fading (W+D > W). Bunavail W+D foil had an indentation outlining the inner film. The W+D bottle tablet had a ˜1 mm nick on one edge. No other differences were noted. After implementing more structured treatment and reviewing the results with the patient, he endorsed fabricating the laundering story to get additional medication. Laundering is an unlikely cause of damaged buprenorphine-containing medication packaged in foil wrappers (Suboxone

  15. The Food and Drug Administration and pragmatic clinical trials of marketed medical products.

    Science.gov (United States)

    Anderson, Monique L; Griffin, Joseph; Goldkind, Sara F; Zeitler, Emily P; Wing, Liz; Al-Khatib, Sana M; Sherman, Rachel E

    2015-10-01

    Pragmatic clinical trials can help answer questions of comparative effectiveness for interventions routinely used in medical practice. Pragmatic clinical trials may examine outcomes of one or more marketed medical products, and they are heterogeneous in design and risk. The Food and Drug Administration is charged with protecting the rights, safety, and welfare of individuals enrolled in clinical investigations, as well as assuring the integrity of the data upon which approval of medical products is made. The Food and Drug Administration has broad jurisdiction over drugs and medical devices (whether or not they are approved for marketing), and as such, clinical investigations of these products are subject to applicable Food and Drug Administration regulations. While many pragmatic clinical trials will meet the criteria for an exemption from the requirements for an investigational new drug application or investigational device exemption, in general, all clinical investigations of medical products that fall under Food and Drug Administration jurisdiction must adhere to regulations for informed consent and review by an institutional review board. We are concerned that current Food and Drug Administration requirements for obtaining individual informed consent may deter or delay the conduct of pragmatic clinical trials intended to develop reliable evidence of comparative safety and effectiveness of approved medical products that are regulated by the Food and Drug Administration. Under current regulations, there are no described mechanisms to alter or waive informed consent to make it less burdensome or more practicable for low-risk pragmatic clinical trials. We recommend that the Food and Drug Administration establish a risk-based approach to obtaining informed consent in pragmatic clinical trials that would facilitate the conduct of pragmatic clinical trials without compromising the protection of enrolled individuals or the integrity of the resulting data. © The Author

  16. Internal dosimetry from IPEN workers involved in the medical radioisotopes production

    International Nuclear Information System (INIS)

    Cesar, R.B.P.; Mesquita, C.H. de

    1988-01-01

    The internal dose from IPEN workers involved in the medical radioisotopes products is related. In the workers population, six groups were classified: development and research, routine production, quality control, package, radioprotection supervision and maintenance. The internal doses were calculated according to the methodology described by the ICRP-30, using resuls from a whole-body counter. The results described were obtained from 970 whole-body radioactivity measurements during the last three years (1985 a 1987). (author) [pt

  17. Scientific Production of Medical Universities in the West of Iran: a Scientometric Analysis.

    Science.gov (United States)

    Rasolabadi, Masoud; Khaledi, Shahnaz; Khayati, Fariba; Kalhor, Marya Maryam; Penjvini, Susan; Gharib, Alireza

    2015-08-01

    This study aimed to compare scientific production by providing quantitative evaluation of science output in five Western Iranian Medical Universities including Hamedan, Ilam, Kermanshah, Kurdistan and Lorestan University of Medical Sciences using scientometrics indicators based on data indexed in Scopus for period between the years 2010 to 2014. In this scientometric study data were collected using Scopus database. Both searching and analyzing features of Scopus were used to data retrieval and analysis. We used Scientometrics indicators including number of publications, number of citations, nationalization index (NI), Internationalization Index (INI), H-index, average number of citations per paper, and growth index. Five Western Iranian Universities produced over 3011 articles from 2010 to 2014. These articles were cited 7158 times with an average rate of 4.2 citations per article. H- Index of under study universities are varying from 14 to 30. Ilam University of Medical Sciences had the highest international collaboration with an INI of 0.33 compared to Hamedan and Kermanshah universities with INI of 0.20 and 0.16 respectively. The lowest international collaboration belonged to Lorestan University of Medical Sciences (0.07). The highest Growth Index belonged to Kurdistan University of Medical Sciences (69.7). Although scientific production of five Western Iranian Medical Universities was increasing, but this trend was not stable. To achieve better performance it is recommended that five Western Iranian Universities stabilize their budgeting and investment policies in research.

  18. 76 FR 66309 - Pilot Program for Parallel Review of Medical Products; Correction

    Science.gov (United States)

    2011-10-26

    ...] Food and Drug Administration [Docket No. FDA-2010-N-0308] Pilot Program for Parallel Review of Medical Products; Correction AGENCY: Food and Drug Administration, Centers for Medicare and Medicaid Services, HHS... technologies to participate in a program of parallel FDA-CMS review. The document was published with an...

  19. 78 FR 21612 - Medical Device Classification Product Codes; Guidance for Industry and Food and Drug...

    Science.gov (United States)

    2013-04-11

    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2011-D-0916] Medical Device Classification Product Codes; Guidance for Industry and Food and Drug Administration Staff; Availability AGENCY: Food and Drug Administration, HHS. ACTION: Notice. SUMMARY: The Food and Drug...

  20. 75 FR 33315 - Dental Products Panel of the Medical Devices Advisory Committee; Notice of Meeting

    Science.gov (United States)

    2010-06-11

    ... received by FDA concerning the final rule on the classification of dental amalgam, which published in the... adequacy of the risk assessment performed by FDA in classifying dental amalgam in light of a new report on... HUMAN SERVICES Food and Drug Administration Dental Products Panel of the Medical Devices Advisory...

  1. Scoping assessment on medical isotope production at the Fast Flux Test Facility

    International Nuclear Information System (INIS)

    Scott, S.W.

    1997-01-01

    The Scoping Assessment addresses the need for medical isotope production and the capability of the Fast Flux Test Facility to provide such isotopes. Included in the discussion are types of isotopes used in radiopharmaceuticals, which types of cancers are targets, and in what way isotopes provide treatment and/or pain relief for patients

  2. Integrating health economics modeling in the product development cycle of medical devices: A Bayesian approach

    NARCIS (Netherlands)

    Vallejo-Torres, Laura; Steuten, Lotte Maria Gertruda; Buxton, Martin J.; Girling, Alan J.; Lilford, Richard J.; Young, Terry

    2008-01-01

    Objectives: Medical device companies are under growing pressure to provide health-economic evaluations of their products. Cost-effectiveness analyses are commonly undertaken as a one-off exercise at the late stage of development of new technologies; however, the benefits of an iterative use of

  3. Community health centers employ diverse staffing patterns, which can provide productivity lessons for medical practices.

    Science.gov (United States)

    Ku, Leighton; Frogner, Bianca K; Steinmetz, Erika; Pittman, Patricia

    2015-01-01

    Community health centers are at the forefront of ambulatory care practices in their use of nonphysician clinicians and team-based primary care. We examined medical staffing patterns, the contributions of different types of staff to productivity, and the factors associated with staffing at community health centers across the United States. We identified four different staffing patterns: typical, high advanced-practice staff, high nursing staff, and high other medical staff. Overall, productivity per staff person was similar across the four staffing patterns. We found that physicians make the greatest contributions to productivity, but advanced-practice staff, nurses, and other medical staff also contribute. Patterns of community health center staffing are driven by numerous factors, including the concentration of clinicians in communities, nurse practitioner scope-of-practice laws, and patient characteristics such as insurance status. Our findings suggest that other group medical practices could incorporate more nonphysician staff without sacrificing productivity and thus profitability. However, the new staffing patterns that evolve may be affected by characteristics of the practice location or the types of patients served. Project HOPE—The People-to-People Health Foundation, Inc.

  4. Medical Isotopes Production Project: Molybdenum-99 and related isotopes: Environmental Impact Statement, Volume I

    International Nuclear Information System (INIS)

    1996-04-01

    This Environmental Impact Statement (EIS) provides environmental and technical information concerning the U.S. Department of Energy's (DOE) proposal to establish a domestic source to produce molybdenum-99 (Mo-99) and related medical isotopes (iodine-131, xenon-133 and iodine-125). Mo-99, a radioactive isotope of the element molybdenum, decays to form metastable technetium-99 (Tc-99m), a radioactive isotope used thousands of times daily in medical diagnostic procedures in the U.S. Currently, all Mo-99 used in the U.S. is obtained from a single Canadian source. DOE is pursuing the Medical Isotopes Production Project in order to ensure that a reliable supply of Mo-99 is available to the U.S. medical community. Under DOE's preferred alternative, the Chemistry and Metallurgy Research Facility at the Los Alamos National Laboratory (LANL) and the Annular Core Research Reactor and Hot Cell Facility at Sandia National Laboratories/New Mexico (SNL/NM) would be used for production of the medical isotopes. In addition to the preferred alternative, three other reasonable alternatives and a no action alternative are analyzed in detail. The sites for the three reasonable alternatives are LANL, Oak Ridge National Laboratory (ORNL), and Idaho National Engineering Laboratory (INEL). The analyses in this EIS indicate no significant difference in the potential environmental impacts among the alternatives. Each of the alternatives would use essentially the same technology for the production of the medical isotopes. Minor differences in environmental impacts among alternatives relate to the extent of activity necessary to modify and restart (as necessary) existing reactors and hot cell facilities at each of the sites, the quantities, of low-level radioactive waste generated, how such waste would be managed, and the length of time needed for initial and full production capacity

  5. Applying Toyota production system techniques for medication delivery: improving hospital safety and efficiency.

    Science.gov (United States)

    Newell, Terry L; Steinmetz-Malato, Laura L; Van Dyke, Deborah L

    2011-01-01

    The inpatient medication delivery system used at a large regional acute care hospital in the Midwest had become antiquated and inefficient. The existing 24-hr medication cart-fill exchange process with delivery to the patients' bedside did not always provide ordered medications to the nursing units when they were needed. In 2007 the principles of the Toyota Production System (TPS) were applied to the system. Project objectives were to improve medication safety and reduce the time needed for nurses to retrieve patient medications. A multidisciplinary team was formed that included representatives from nursing, pharmacy, informatics, quality, and various operational support departments. Team members were educated and trained in the tools and techniques of TPS, and then designed and implemented a new pull system benchmarking the TPS Ideal State model. The newly installed process, providing just-in-time medication availability, has measurably improved delivery processes as well as patient safety and satisfaction. Other positive outcomes have included improved nursing satisfaction, reduced nursing wait time for delivered medications, and improved efficiency in the pharmacy. After a successful pilot on two nursing units, the system is being extended to the rest of the hospital. © 2010 National Association for Healthcare Quality.

  6. The public production and sharing of medical information. An Australian perspective

    Directory of Open Access Journals (Sweden)

    Henry C.H. Ko

    2010-03-01

    Full Text Available There is a wealth of medical information now available to the public through various sources that are not necessarily controlled by medical or healthcare professionals. In Australia there has been a strong movement in the health consumer arena of consumer-led sharing and production of medical information and in healthcare decision-making. This has led to empowerment of the public as well as increased knowledge-sharing. There are some successful initiatives and strategies on consumer- and public-led sharing of medical information, including the formation of specialised consumer groups, independent medical information organisations, consumer peer tutoring, and email lists and consumer networking events. With well-organised public initiatives and networks, there tends to be fairly balanced information being shared. However, there needs to be caution about the use of publicly available scientific information to further the agenda of special-interest groups and lobbying groups to advance often biased and unproven opinions or for scaremongering. With the adoption of more accountability of medical research, and the increased public scrutiny of private and public research, the validity and quality of medical information reaching the public is achieving higher standards.

  7. Direct production of 99mTc using a small medical cyclotron

    Energy Technology Data Exchange (ETDEWEB)

    Lapi, Suzanne [Washington Univ., St. Louis, MO (United States)

    2017-10-03

    This project describes an investigation towards the production of 99mTc with a small medical cyclotron. This endeavor addresses the current urgent problem of availability of 99mTc due to the ongoing production reactor failures and the upcoming Canadian reactor shut down. Currently, 99mTc is produced via nuclear fission using highly enriched uranium which is a concern due to nuclear proliferation risks. In addition to this, the United States is dependent solely on currently unreliable foreign sources of this important medical isotope. Clearly, a need exists to probe alternative production routes of 99mTc. In the first year, this project measured cross-sections and production yields of potential pathways to 99mTc and associated radionuclidic impurities produced via these pathways using a small 15 MeV medical cyclotron. During the second and third years target systems for the production of 99mTc via the most promising reaction routes were developed and separation techniques for the isolation of 99mTc from the irradiated target material will be investigated. Systems for the recycling of the enriched target isotopes as well as automated target processing systems were examined in years four and five. This project has the potential to alleviate some of the current crisis in the medical community by developing a technique to produce 99mTc on location at a university hospital. This technology will be applicable at many other sites in the United States as many other similar, low energy (<20 MeV) cyclotrons (currently used for a few hours per day for the production of [18F]fluorodeoxyglucose) are available for production of 99mTc though this method, thus leading to job creation and preservation.

  8. Economic Spillovers From Public Investments in Medical Countermeasures: A Case Study of a Burn Debridement Product.

    Science.gov (United States)

    Farahati, Farah; Nystrom, Scott; Howell, David R; Jaffe, Richard

    2017-12-01

    The US federal government invests in the development of medical countermeasures for addressing adverse health effects to the civilian population from chemical, biological, and radiological or nuclear threats. We model the potential economic spillover effects in day-to-day burn care for a federal investment in a burn debridement product for responding to an improvised nuclear device. We identify and assess 4 primary components for projecting the potential economic spillover benefits of a burn debridement product: (1) market size, (2) clinical effectiveness and cost-effectiveness, (3) product cost, and (4) market adoption rates. Primary data sources were the American Burn Association's 2015 National Burn Repository Annual Report of Data and published clinical studies used to gain European approval for the burn debridement product. The study results showed that if approved for use in the United States, the burn debridement product has potential economic spillover benefits exceeding the federal government's initial investment of $24 million a few years after introduction into the burn care market. Economic spillover analyses can help to inform the prioritizing of scarce resources for research and development of medical countermeasures by the federal government. Future federal medical countermeasure research and development investments could incorporate economic spillover analysis to assess investment options. (Disaster Med Public Health Preparedness. 2017;11:711-719).

  9. Noor-Eesti rollist eesti kirjandus- ja kultuuriloos. The Role of Young Estonia in Estonian Literary and Cultural History

    Directory of Open Access Journals (Sweden)

    Sirje Olesk

    2012-04-01

    Full Text Available From the beginning of the 20th century on, the activities of the Young Estonia literary movement have had a significant influence on the development of Estonian culture. The group published five Young Estonia albums (1905–1915, the magazine Young Estonia, devoted to science, literature, and the arts (1910– 1911, and the newspaper Vaba Sõna (1914–1916, Free Word. The core of the group was composed of five or six active writers who maintained lively interactions with art and theatre circles. The publications of the Young Estonia Press brought about a revolutionary turn in the design and printing styles of the Estonian-language book. The questions of Young Estonia’s role and meaning have intrigued the Estonian cultural public at different times and in different ways. Young Estonia brought to cultural consciousness liberal views on the interpretation of art as well as an elitist aesthetics. At different times their openness to Europe irritated both the nationalist-minded and internationalists; thus the reception of the Young Estonia movement has been polemical throughout Estonian cultural history. Elapsed time has both opened the way for broader generalizations and, conversely, created a need to reconstruct the cultural context of the beginning of the 20th century. Polemic around Young Estonia was certainly caused by the group as a whole; however, in this article the role of individual members is also highlighted. It is emphasized that the political and aesthetic ideas of the Young Estonians changed synchronously with social conditions, from the 1905 Russian revolution to the world war that ravaged Europe. If the early part of this period saw a more social and nationalist bent to their thinking, then in the years of reaction, positions were taken that were more in keeping with l’art pour l’art. Young Estonia was not a hierarchical organization; rather, its small core group was composed of a narrow circle of friends with various

  10. Validation of an Estonian version of the Parkinson's Disease Questionnaire (PDQ-39

    Directory of Open Access Journals (Sweden)

    Lai Taavi

    2008-03-01

    Full Text Available Abstract Introduction Diagnosis and management of Parkinson's disease (PD rely heavily on evaluation of clinical symptoms and patients' subjective perception of their condition. The purpose of this study was to evaluate the validity, acceptability, and reliability of the Estonian version of the 39-question Parkinson 's disease Questionnaire (PDQ-39. Methods Study subjects were approached during their regular clinic follow-up visits. 104 patients consented to the study and 81 completed questionnaires were used for subsequent testing of psychometric characteristics, validity and reliability. Results The content validity was assessed through qualitative content analysis during the pilot study. The patients indicated that the questions were relevant to measure the quality of life of people with PD. The analysis of means showed that the ceiling and floor effects of domain results were within the limits of 15% of Summary Index and of all domains except Stigma, Social Support and Communication where the ceiling effect was 16% to 24% of the responses. Convergent validity was interpreted through correlation between disease severity and PDQ-39 domains. There was a statistically significant difference between the domain scores in patients with mild versus moderate PD in domains of Mobility, ADL, and Communication but not for Stigma, Social Support and Cognition. The reliability was good, Cronbach alpha for all domains and summary index was over 0.8 and item-test correlations between domains and summary index ranged from 0.56 to 0.83. Conclusion The psychometric characteristics of an Estonian version of the PDQ-39 were satisfactory. The results of this study were comparable to the results of previous validation studies in other cultural settings in UK, USA, Canada, Spain and Italy. The Estonian version of the PDQ-39 is an acceptable, valid and reliable instrument for quality of life measurement in PD patients.

  11. Trends in smoking behaviour among Estonian physicians in 1982-2014.

    Science.gov (United States)

    Pärna, Kersti; Põld, Mariliis; Ringmets, Inge

    2017-07-25

    Smoking surveys among physicians have proved useful in highlighting the importance of physicians as healthy life style exemplars and role models in tobacco control and smoking cessation. The aim of this study was to give an overview of smoking behaviour among Estonian physicians from 1982 to 2014. Three cross-sectional postal surveys using a self-administered questionnaire were carried out among all practising physicians in Estonia. The number of physicians participating in this study was 3786 in 1982, 2735 in 2002, and 2902 in 2014. Data analysis involved calculating the age-standardized prevalences of smoking, prevalences of smoking by age group and mean age of smoking initiation. A non-parametric test for trend was used to assess significant changes in smoking over time. Age-standardized prevalence of current smoking among men was 39.7% in 1982, 20.9% in 2002, and 14.3% in 2014 and among women 12.2%, 8.0%, and 5.2%, respectively (p smoking among men and women was in age groups under 35 (from 55.2% to 16.7% and from 16.7% to 2.8%, respectively) and 35-44 (from 47.1% to 8.3% and from 19.5% to 5.1%, respectively) (p smoking initiation decreased from 20.4 to 19.3 among men and from 24.5 to 20.4 among women over the study period. In 1982-2014, smoking prevalence among Estonian physicians declined substantially. This may influence the willingness of society to recognize the health consequences of smoking which could give a support to the decline of the smoking epidemic in the country. Differences between smoking among male and female physicians persisted over the study period, but mean age of smoking initiation decreased. A further decline in smoking among Estonian physicians should be encouraged by special efforts targeted at physicians.

  12. Pilk ingliskeelse kirjanduse tõlgetele 18. sajandi lõpust 20. sajandi algusveerandini / A Look at Estonian Translations of English Literature from the late 18th Century to the Early 20th Century

    Directory of Open Access Journals (Sweden)

    Krista Mits

    2012-06-01

    Full Text Available The aim of this article is to provide an overview of translations of English literature into Estonian between 1779 and 1917. There is an attempt to analyse the texts by describing them on the basis of, or in their departure from, a text or texts that chronologically and logically precede them. The discussion includes the nature of the transfer and the changes that have been made to the text, either because they existed in the source or mediating text or because of the expectations or requirements in the receptor, i.e. Estonian culture. The translated texts are seen in their historical-cultural context. For the analysis, a corpus of translated texts – religious, fiction, drama and non-fiction (published in a book form was compiled. The general orientation of Estonia until the 1880s was to the German cultural sphere. So the first translations of English literature were made via a mediating language, which was German. English Puritan writers were introduced by the Pietist missionaries with the aim of spreading their teachings in the second half of the 18th century. At about the same time the narrative element was introduced into stories with religious content. Some internationally popular stories, e.g. the Inkle and Yarico story, later robinsonades, stories of slavery and plant at ion life, as well as Amer ican Indian st or ies wer e also t r anslat ed fr om Ger man. However, until  1875  ver  y  few  translations  of  English  literature  into  E stonian were  published.  The  last quarter of the 19th century saw an explosion in literary production: there was a substantial increase  both  in  the  number  of  translations  of  English  literature  into  E stonian  as  well  as diversification of genres. This continued into the first decade of the 20th  centur y,  when  the sociopolitical situation in Estonia changed. In addition, books came to be translated directly from  English,  although  many  translations

  13. Estonian experience in establishing the national radiation protection infrastructure in the newly independent State

    International Nuclear Information System (INIS)

    Kalam, J.

    2001-01-01

    The Estonian Radiation Protection Centre (ERPC) was established on 4 January 1996 as the regulatory authority for radiation protection and safety of radiation sources. The report explains the ERPC's structure and its main functions and activities, and provides information on the regulations that have been approved or are planned to be adopted. Reference is made to radiological emergency preparedness and, in particular, to the status of development of the system of regulatory control by authorization and inspection of radiation practices in the country. (author)

  14. Variation in tryptophan hydroxylase-2 gene is not associated to male completed suicide in Estonian population.

    Science.gov (United States)

    Must, Anne; Tasa, Gunnar; Lang, Aavo; Vasar, Eero; Kõks, Sulev; Maron, Eduard; Väli, Marika

    2009-04-03

    Dysfunction of the central serotonergic system has been related to a spectrum of psychiatric disorders, including suicidal behavior. Tryptophan hydroxylase isoform 2 (TPH2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. We investigated genetic variation in TPH2 gene in two samples of male subjects: 288 suicide completers and 327 volunteers, in order to reveal any associations between 14 single nucleotide polymorphisms and completed suicide. No associations were revealed neither on allelic nor haplotype level. Our finding does not support the hypothesis of TPH2 being a susceptibility factor for completed suicide in males of Estonian origin.

  15. Safety evaluation in the development of medical devices and combination products

    CERN Document Server

    Gad, Shayne C

    2008-01-01

    Capturing the growth of the global medical device market in recent years, this practical new guide is essential for all who are responsible for ensuring safety in the use and manufacture of medical devices. It has been extensively updated to reflect significant advances, incorporating combination products and helpful case examples of current real-life problems in the field.The Third Edition explores these key current trends:global device marketscontinually advancing technologythe increasing harmonization of device safety regulation worldwideEach aspect of safety evaluation is considered in ter

  16. Medical Isotope Production With The Accelerator Production of Tritium (APT) Facility

    Energy Technology Data Exchange (ETDEWEB)

    Buckner, M.; Cappiello, M. [Westinghouse Savannah River Co., Aiken, SC (United States); Pitcher, E. [Los Alamos National Laboratory, Los Alamos, NM (United States); O`Brien, H. [O`Brien and Associates, Los Alamos, NM (United States)

    1998-08-01

    In order to meet US tritium needs to maintain the nuclear weapons deterrent, the Department of Energy (DOE) is pursuing a dual track program to provide a new tritium source. A record of decision is planned for late in 1998 to select either the Accelerator Production of Tritium (APT) or the Commercial Light Water Reactor (CLWR) as the technology for new tritium production in the next century. To support this decision, an APT Project was undertaken to develop an accelerator design capable of producing 3 kg of tritium per year by 2007 (START I requirements). The Los Alamos National Laboratory (LANL) was selected to lead this effort with Burns and Roe Enterprises, Inc. (BREI) / General Atomics (GA) as the prime contractor for design, construction, and commissioning of the facility. If chosen in the downselect, the facility will be built at the Savannah River Site (SRS) and operated by the SRS Maintenance and Operations (M{ampersand}O) contractor, the Westinghouse Savannah River Company (WSRC), with long-term technology support from LANL. These three organizations (LANL, BREI/GA, and WSRC) are working together under the direction of the APT National Project Office which reports directly to the DOE Office of Accelerator Production which has program authority and responsibility for the APT Project.

  17. Medical Isotope Production With The Accelerator Production of Tritium (APT) Facility

    International Nuclear Information System (INIS)

    Buckner, M.; Cappiello, M.; Pitcher, E.; O'Brien, H.

    1998-01-01

    In order to meet US tritium needs to maintain the nuclear weapons deterrent, the Department of Energy (DOE) is pursuing a dual track program to provide a new tritium source. A record of decision is planned for late in 1998 to select either the Accelerator Production of Tritium (APT) or the Commercial Light Water Reactor (CLWR) as the technology for new tritium production in the next century. To support this decision, an APT Project was undertaken to develop an accelerator design capable of producing 3 kg of tritium per year by 2007 (START I requirements). The Los Alamos National Laboratory (LANL) was selected to lead this effort with Burns and Roe Enterprises, Inc. (BREI) / General Atomics (GA) as the prime contractor for design, construction, and commissioning of the facility. If chosen in the downselect, the facility will be built at the Savannah River Site (SRS) and operated by the SRS Maintenance and Operations (M ampersand O) contractor, the Westinghouse Savannah River Company (WSRC), with long-term technology support from LANL. These three organizations (LANL, BREI/GA, and WSRC) are working together under the direction of the APT National Project Office which reports directly to the DOE Office of Accelerator Production which has program authority and responsibility for the APT Project

  18. A conversion development program to LEU targets for medical isotope production in the MAPLE Facilities

    International Nuclear Information System (INIS)

    Malkoske, G.R.

    2000-01-01

    Historically, the production of molybdenum-99 in the NRU research reactors at Chalk River, Canada has been extracted from reactor targets employing highly enriched uranium (HEU). The molybdenum extraction process from the HEU targets provided predictable, consistent yields for our high-volume molybdenum production process. A reliable supply of HEU for the NRU research reactor targets has enabled MDS Nordion to develop a secure chain of medical isotope supply for the international nuclear medicine community. Each link of the isotope supply chain, from isotope production to patient application, has been established on a proven method of HEU target irradiation and processing. To ensure a continued reliable and timely supply of medical isotopes, the design of the MAPLE facilities was based on our established process - extraction of isotopes from HEU target material. However, in concert with the global trend to utilize low enriched uranium (LEU) in research reactors, MDS Nordion has launched a program to convert the MAPLE facilities to LEU targets. An initial feasibility study was initiated to identify the technical issues to convert the MAPLE targets from HEU to LEU. This paper will present the results of the feasibility study. It will also describe future challenges and opportunities in converting the MAPLE facilities to LEU targets for large scale, commercial medical isotope production. (author)

  19. Productivity assessment of physician assistants and nurse practitioners in oncology in an academic medical center.

    Science.gov (United States)

    Moote, Marc; Nelson, Ron; Veltkamp, Robin; Campbell, Darrell

    2012-05-01

    Demand for oncologists will increase dramatically over the next 15 years. Physician assistants (PAs) and Nurse practitioners (NPs) have been identified as one solution to meet the projected shortages in oncology. It has previously been reported that 56% of oncologists work with PAs and NPs, more than two thirds of whom believe it benefits their practice with some noted productivity advantages. The purpose of this study was to quantify the productivity of PAs and NPs working in oncology in an academic medical center. A 2-week self-reported time study was performed in a single large academic medical center. Services were categorized as billable, bundled, care facilitation, administrative, and other based on time spent performing services in each category. Current procedural terminology codes were used to determine the economic value of services provided. A total of 54 PAs and NPs were included in the final analysis. PAs and NPs reported similar clinical activities. Overall, there was high variability noted in terms of productivity, notably with PA/NP direct billable revenue. Opportunities were identified to improve utilization of oncology PAs and NPs, with suggestions for future research related to PA and NP productivity tracking. Productivity measurement for PAs and NPs can be challenging. To our knowledge, this is the first study that quantifies PA and NP productivity in oncology according to known economic indicators such as charges and work relative value units.

  20. Evaluation Study for the Production of the Medical Isotope ^90Y, using a Cyclotron

    Science.gov (United States)

    Necsoiu, D.; Morgan, I. L.; Hupf, Homer; Armbruster, J.; Boyce, D.; El Bouanani, M.; McDaniel, F. D.

    2000-10-01

    The use of radioisotopes in therapy, medical imaging and laboratory tests is well-established worldwide. ^90Y is a very good therapeutic candidate for radioimmunotherapy applications. Traditionally, medical radioisotopes are produced using either nuclear reactors or proton accelerators. In this study, the medical isotope ^90Y has been produced using ^90Zr(n,p)^90Y nuclear reaction. Neutrons for the activation process were produced using ^natRh(p,xn) reaction with a 27 MeV proton beam from a cyclotron. Since ^90Y is a pure beta emitter, the gamma rays from the ^90Zr(n,2n)^89Zr reaction were used to quantify the incident neutron flux on the ^90Zr sample. Experimental results of the neutron production and ^90Y activity are presented.

  1. Modeling and simulation for medical product development and evaluation : highlights from the FDA-C-Path-ISOP 2013 workshop

    NARCIS (Netherlands)

    Romero, Klaus; Sinha, Vikram; Allerheiligen, Sandra; Danhof, Meindert; Pinheiro, Jose; Kruhlak, Naomi; Wang, Yaning; Wang, Sue-Jane; Sauer, John-Michael; Marier, J. F.; Corrigan, Brian; Rogers, James; Heerspink, H. J. Lambers; Gumbo, Tawanda; Vis, Peter; Watkins, Paul; Morrison, Tina; Gillespie, William; Gordon, Mark Forrest; Stephenson, Diane; Hanna, Debra; Pfister, Marc; Lalonde, Richard; Colatsky, Thomas

    2014-01-01

    Medical-product development has become increasingly challenging and resource-intensive. In 2004, the Food and Drug Administration (FDA) described critical challenges facing medical-product development by establishing the critical path initiative [1]. Priorities identified included the need for

  2. 78 FR 10181 - Global Quality Systems-An Integrated Approach To Improving Medical Product Safety; Public Workshop

    Science.gov (United States)

    2013-02-13

    ...] Global Quality Systems--An Integrated Approach To Improving Medical Product Safety; Public Workshop... (AFDO), is announcing a public workshop entitled ``Global Quality Systems--An Integrated Approach to Improving Medical Product Safety.'' This 2-day public workshop is intended to provide information about FDA...

  3. Encountering Challenges with the EU Regulation on Advance Therapy Medical Products.

    Science.gov (United States)

    Mansnérus, Juli

    2015-12-01

    This article aims at analysing how well the Advanced Therapy Medical Product Regulation (EC) No. 1394/2007 (ATMP Regulation) meets the needs of small and medium-sized enterprises (SMES), academia and public tissue establishments developing advanced therapy medical products (ATMPS). Benefits and shortcomings of the ATMP Regulation are identified, and possible amendments are proposed to accelerate the translation of research into advanced therapies and to facilitate the commercialisation of ATMPS whilst ensuring safety. It was set up as a lex specialis to ensure the free movement of ATMPS within the EU in order to facilitate their access to the internal market and to foster the competitiveness of European pharmaceutical companies, while guaranteeing the highest level protection of public health. Since the adoption of the ATMP Regulation in late 2008, only 5 ATMPS have been granted marketing authorisations thus far. Hence, there is a need to analyse whether the ATMP Regulation meets its objectives.

  4. Production of medical radioactive isotopes using KIPT electron driven subcritical facility

    International Nuclear Information System (INIS)

    Talamo, Alberto; Gohar, Yousry

    2008-01-01

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine in collaboration with Argonne National Laboratory (ANL) has a plan to construct an electron accelerator driven subcritical assembly. One of the facility objectives is the production of medical radioactive isotopes. This paper presents the ANL collaborative work performed for characterizing the facility performance for producing medical radioactive isotopes. First, a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Then, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes have been considered and all transmutation channels are used including (n, γ), (n, 2n), (n, p), and (γ, n). In the second part, the parent isotopes with high reaction rate were explicitly modeled in the calculations. Four irradiation locations were considered in the analyses to study the medical isotope production rate. The results show the self-shielding effect not only reduces the specific activity but it also changes the irradiation location that maximizes the specific activity. The axial and radial distributions of the parent capture rates have been examined to define the irradiation sample size of each parent isotope

  5. Hysteroscopic removal of retained products of conception following first trimester medical abortion

    Directory of Open Access Journals (Sweden)

    Noam Smorgick

    2017-11-01

    Full Text Available Study Objective: To investigate the use of operative hysteroscopy instead of traditional curettage in women with retained products of conception (RPOC following first trimester medical abortion, with the aim of reducing post-operative intrauterine adhesions. Design: Retrospective study. Setting: Gynecology department in a University affiliated hospital. Patients: All women treated by hysteroscopy for RPOC following first trimester medical abortion using the mifepristone-misoprostol protocol for pregnancy termination or the misoprostol protocol for early missed abortion from January 2013 to August 2016. Intervention: Operative hysteroscopy for removal of RPOC. Post-operative intrauterine adhesions were assessed by diagnostic office hysteroscopy after 6–8 weeks. Measurements and Main Results: 50 cases were identified. The mean time from medication administration to the operative hysteroscopy was 1.7 ± 0.7 months. Operative hysteroscopy with blunt use of the resectoscopic loop was used to remove all specimens, and all procedures were completed without intra-operative complications. Two patients (4.0% were readmitted for fever. Pathology confirmed the presence of RPOC in 45 (90.0% cases. On follow-up office hysteroscopy, a normal uterine cavity without evidence of intrauterine adhesions was seen in 29/29 (100% women. Conclusion: Hysteroscopy for removal of RPOC following medical abortion is associated with low rates of complications and post-operative intrauterine adhesions. Keywords: abortion, hysteroscopy, intrauterine adhesions, retained products of conception

  6. Exploring Constructivist Social Learning Practices in Aiding Russian-Speaking Teachers to Learn Estonian: An Action Research Approach

    Science.gov (United States)

    Kiilo, Tatjana; Kutsar, Dagmar

    2012-01-01

    Based on appreciative inquiry and threshold concepts from an intercultural learning perspective, the article makes insights into the constructivist social learning practice of Estonian language learning amongst Russian-speaking teachers in Estonia. The application of educational action research methodology, more specifically that of Bridget…

  7. Proficiency Assessment of Male Volleyball Teams of the 13-15-Year Age Group at Estonian Championships

    Science.gov (United States)

    Stamm, Meelis; Stamm, Raini; Koskel, Sade

    2008-01-01

    Study aim: Assessment of feasibility of using own computer software "Game" at competitions. Material and methods: The data were collected during Estonian championships in 2006 for male volleyball teams of the 13-15-years age group (n = 8). In all games, the performance of both teams was recorded in parallel with two computers. A total of…

  8. The Winding Road on the Media Landscape: The Establishment of Estonian (Television) Broadcasting between 1992 and 2016

    NARCIS (Netherlands)

    Jõesaar, Andres

    2017-01-01

    textabstractThis article aims to explore the ways in which Estonian broadcasting (with a focus on television) tackled the challenges of transforming from a monopolistic party propaganda machine into a modern dual media system in which public service broadcasting and newly created private enterprises

  9. Enhancing Teachers' Curriculum Ownership via Teacher Engagement in State-Based Curriculum-Making: The Estonian Case

    Science.gov (United States)

    Mikser, Rain; Kärner, Anita; Krull, Edgar

    2016-01-01

    Teachers' curriculum ownership is increasingly gaining attention in many countries. It is particularly important that under the conditions of centralized curriculum-making, teachers as final implementers of curricular ideas identify themselves with these ideas. This study investigates Estonian upper secondary school teachers' views on the impact…

  10. Physics, chemistry, technology and quality assurance in radionuclide production for medical applications

    International Nuclear Information System (INIS)

    Qaim, Syed M.

    2006-01-01

    A brief description of the types of radionuclides used in medicine is given. The role of physics, particularly of nuclear data, in the optimisation of a production process is described, and the importance of chemical methods, especially of radiochemical separations, in obtaining the desired radionuclide in a chemically pure form is discussed. The sophisticated targetry needed for cyclotron production of short-lived radionuclides for Positron Emission Tomography (PET) is treated in some detail. The quality control of radionuclides produced for medical applications is discussed. (author)

  11. Pilot material handling system for radiation processing of agricultural and medical products

    International Nuclear Information System (INIS)

    Sandha, R.S.; Nageswar Rao, J; Dwivedi, Jishnu; Petwal, V.C.; Soni, H.C.

    2005-01-01

    A 10 MeV, 10 kW electron LINAC based radiation processing facility is being constructed at Centre for Advanced Technology, Indore for radiation processing of various food products like potatoes, onion, spices, home pack items and medical sterilization. A pilot material handling system has been designed, manufactured, and installed at CAT to verify process parameters viz. conveying speed, dose uniformity, and to study the effect of packing shape and size for radiation processing of different product. This paper describes various features of pilot material handling system. (author)

  12. Estimate of production of medical isotopes by photo-neutron reaction at the Canadian Light Source

    Science.gov (United States)

    Szpunar, B.; Rangacharyulu, C.; Daté, S.; Ejiri, H.

    2013-11-01

    In contrast to conventional bremsstrahlung photon beam sources, laser backscatter photon sources at electron synchrotrons provide the capability to selectively tune photons to energies of interest. This feature, coupled with the ubiquitous giant dipole resonance excitations of atomic nuclei, promises a fertile method of nuclear isotope production. In this article, we present the results of simulations of production of the medical/industrial isotopes 196Au, 192Ir and 99Mo by (γ,n) reactions. We employ FLUKA Monte Carlo code along with the simulated photon flux for a beamline at the Canadian Light Source in conjunction with a CO2 laser system.

  13. Future growth in the gamma sterilization of disposable medical products (DMPs)

    International Nuclear Information System (INIS)

    Brinston, R.M.

    1990-01-01

    An estimated 361 million cubic feet (10 million cubic meters) of disposable medical products and related health care items are currently being sterilized around the world. Ethylene oxide gas is used to treat approximately 252 million cubic feet (7.1 million cubic meters), gamma radiation is used to sterilize approximately 99 million cubic feet (2.8 million cubic meters), and electron beam is used on approximately 10 million cubic feet (0.3 million cubic meters) of disposable medical products (DMPs). Market share for each of these terminal cold sterilization processes are 70%, 27%, and 3% respectively. There are a number of factors which are affecting the overall growth of the market. The most important factors are summarized. Balancing all of these factors, the pre-sterilized disposable products market is forecasted to grow on average of 5% per year. Gamma radiation is experiencing growth from both general market growth and the introduction of new products, as well as the conversion of product from ethylene oxide (EtO) to cobalt-60 sterilization. Electron beam usage while experiencing good growth in the early 1980s, is predicted to have a flat growth curve during the late 1980s, and then start to experience renewed growth in the mid to late 1990s as two or three new electron beam facilities are built. In the late 1990s other potentially competing technologies are expected to have an impact on the market place. (author)

  14. Tabud ja reeglid. Sissevaateid eesti laagriromaani / Taboos and Rules. Insights into Prison Camp Novels by Estonian Writers

    Directory of Open Access Journals (Sweden)

    Anneli Kõvamees

    2013-12-01

    Full Text Available The article concentrates on Estonian novels depicting Soviet prison camps in the 1940s and 1950s. The goal is to map themes, motifs and characteristics in such novels, concentrating on various taboos and rules in the prison camp environment. For a long time the Soviet prison camp theme was not publicly discussed in Estonia due to political reasons. Texts dealing with prison camps could appear in print only outside the Soviet Union; the way Estonians saw these historical events and hellish experiences were depicted mostly in exile novels. Most notable are the novels by Arved Viirlaid (b. 1922, e.g., Kes tappis Eerik Hormi? (Who Killed Eerik Horm? (1974, Surnud ei loe (The Dead do not Read (1975, Vaim ja ahelad (Mind and Chains (1961. Estonian prison camp novels can be seen as “the literature of testimony”, to use the term by Leona Toker. Dramatic historical events are written down to record the events and to show the inhumane nature of Soviet society. These records of the dramatic past follow certain patterns and create certain self- and hetero-images. A prison camp is a closed territory within a closed territory; prison camps can be seen as small models of Soviet society. Prison camp novels give a detailed view of the environment of the prison camp, its inhabitants and activities. Two central aspects are labour and food; the life of the prisoner whirls around these. The most important thing is to survive, which often leads to moral decline, e.g., stealing, cheating. However, there are lines Estonians do not cross, e.g., cannibalism or homosexual relationships with superiors. Estonians are always depicted as political prisoners (not common criminals and heterosexuals, while Russians are portrayed mainly as criminals and often also as homosexuals. Another important component of the image of the Estonians is their enterprising spirit and ability to manage even under very difficult conditions. Therefore, several oppositions can be identified, e

  15. Maximum reasonable radioxenon releases from medical isotope production facilities and their effect on monitoring nuclear explosions.

    Science.gov (United States)

    Bowyer, Theodore W; Kephart, Rosara; Eslinger, Paul W; Friese, Judah I; Miley, Harry S; Saey, Paul R J

    2013-01-01

    Fission gases such as (133)Xe are used extensively for monitoring the world for signs of nuclear testing in systems such as the International Monitoring System (IMS). These gases are also produced by nuclear reactors and by fission production of (99)Mo for medical use. Recently, medical isotope production facilities have been identified as the major contributor to the background of radioactive xenon isotopes (radioxenon) in the atmosphere (Stocki et al., 2005; Saey, 2009). These releases pose a potential future problem for monitoring nuclear explosions if not addressed. As a starting point, a maximum acceptable daily xenon emission rate was calculated, that is both scientifically defendable as not adversely affecting the IMS, but also consistent with what is possible to achieve in an operational environment. This study concludes that an emission of 5 × 10(9) Bq/day from a medical isotope production facility would be both an acceptable upper limit from the perspective of minimal impact to monitoring stations, but also appears to be an achievable limit for large isotope producers. Copyright © 2012 Elsevier Ltd. All rights reserved.

  16. A study on sterilization of medical products by gamma-irradiation

    International Nuclear Information System (INIS)

    Moon, P.S.; Chung, H.W.; Zong, M.S.

    1978-01-01

    Biological safety, physico-chemical and microbiological experiments were carried out in order to study the possibility of radiation sterilization on medical products, such as polyethylene and polystyrene bottles, gauze, sponges and surgical silk suture. Results are as follows; Biological test on plastic samples as to acute systemic toxicity, eye irritation, skin irritation, pyrogen, haemolysis showed satisfactory results. But physico-chemically, the oxidizable matter, nonvolatile residues, residue on ignition seemed to be increased slightly in irradiated samples, though the experimental results were within the range of U.S.P. 19, N.F. and K.P. III. After irradiation, both plastic and gauze sponges showed considerable decrease in pH. Most medical products were sterilized by 1.5 Mrad. For the sterilization of the surgical silk suture, 4.5 Mrad is required due to its radiation resistant micro-organisms. Biologically, total dose of 2.5 Mrad was safe enough to sterilize the medical products, and physico-chemically the results are acceptable according to U.S.P. 19 and K.P. III. However better results may be expected when the quality of material and additives are improved. (author)

  17. Scientific production in Colombian medical schools during the last 15 years

    Directory of Open Access Journals (Sweden)

    Nubia Fernanda Sánchez-Bello

    2016-10-01

    Full Text Available Introduction: The growth of medical schools in Colombia has been rapid, although State control is not strict; therefore, many questionable aspects can be found, among them, the ability to generate research and new knowledge. Objective: To describe scientific production related to Medicine between 2001 and 2015 in Colombian universities. Materials and methods: Cross-sectional study in which scientific production incorporated in the SCOPUS database in the last 15 years was reviewed, including all work done by the 62 medical schools registered before the Ministry of National Education. Results: The total number of scientific publications made during the observation period was 14 167. The five institutions with the highest number of publications were Universidad de Antioquia, Universidad Nacional de Colombia, Universidad del Valle, Pontificia Universidad Javeriana and Colegio Mayor de Nuestra Señora del Rosario. The first 10 faculties generated 78.5% of the total publications. Conclusions: The volume of identified scientific production is produced by a few medical schools. The results of this study can be taken as an approach to the way how quality in Colombian higher education institutions is currently measured, especially in medicine schools.

  18. BASIC COLOUR TERMS IN FIVE FINNOUGRIC LANGUAGES AND ESTONIAN SIGN LANGUAGE: A COMPARATIVE STUDY

    Directory of Open Access Journals (Sweden)

    Liivi Hollman

    2012-01-01

    Full Text Available In this paper we compare five Finno-Ugric languages – Estonian,Finnish, Hungarian, Udmurt and Komi-Zyrian – and the Estonian Sign Language (unclassified in different aspects: established basic colour terms, the proportion of basic colour terms and different colour terms in the collected word-corpora, the cognitive salience index values in the list task and the number of dominant colour tiles in the colour naming task. The data was collected, using the field method of Davies and Corbett, from all languages under consideration, providing a distinctive foundation for linguistic comparison. We argue that Finno-Ugric languages seem to possess relatively large colour vocabularies,especially due to their rich variety of word-formation types,e.g. the composition of compound words. All of the languages under consideration have developed to Stage VI or VII, possessing 7 to 11lexicalised basic colour terms. The cognitive salience index helps to distinguish primary and secondary basic colour terms, showing certain comprehensive patterns which are similar to Russian and English.

  19. Behind the Curtains of e-State: Determinants of Online Sexual Harassment among Estonian Children

    Directory of Open Access Journals (Sweden)

    Veronika Kalmus

    2012-11-01

    Full Text Available This article analyses the risk of receiving online sexual messages and experiencing harm among Estonian children. In particular, the paper examines the association between receiving sexual messages and behavioural, psychological and demographic characteristics, and the social mediation of children’s Internet use. Estonian data from EU Kids Online survey are used, involving 780 children aged 11-16. Results demonstrate that 19% of children who use the Internet have received online sexual messages, and 6% have felt disturbed. The probability of receiving sexual messages online is higher for children with risky online and offline behaviour and psychological difficulties. Perceiving online messages as sexually harassing is higher among children with excessive Internet use, lower levels of parental monitoring and higher levels of peer mediation of Internet use. The risk of exposure to harassing sexual messages also differs by age and, more notably, by the minority status. Mediation by parents and teachers plays an insignificant role in reducing teenagers’ risks of receiving sexual messages.

  20. Radon in Estonian buildings. Establishment of a measurement system and obtained results

    International Nuclear Information System (INIS)

    Pahapill, L.; Rulkov, A.; Swedjemark, G.A.

    1996-12-01

    One purpose of this project was the establishment of a radon monitoring programme inside the state environmental monitoring programme. Another purpose was to investigate regions, expected to have high radon levels indoors. A new method for the long-term measurement of indoor radon was established and the staff for these measurements was trained. The results of the measurement can be used by Estonian decision-makers to work out rules and standards. There is no legislative act in the field of radiation in Estonian at this time. To summarize the results of the measurements we can say that indoor radon concentrations vary by region. The radon investigations must be continued to identify the risk areas and types of housing construction. The results of the state radon monitoring are provided to the municipalities, who advice the owners of planned new houses to select the right construction for the house. A new project will follow with an investigation of radon in randomly selected dwellings, training and equipment for radon measurement in soil, and general advice with regard to radon, as well as assistance in preparing information about radon. 7 refs, 5 figs

  1. Cultural Value Differences, Value Stereotypes, and Diverging Identities in Intergroup Conflicts: The Estonian Example

    Directory of Open Access Journals (Sweden)

    Henrik Dobewall

    2011-07-01

    Full Text Available

    An examination of the relationship between cultural values, value stereotypes and social identities in Estonia, where intergroup conflicts triggered riots in the capital
    Tallinn in April 2007, using data from the European Social Survey on cultural differences and value trends as the background to a survey exploring perceived
    group values and assessed social identities among ethnic Estonians and members of the Russian-speaking minority. The study, conducted in summer 2008, found
    agreement across both ethnic groups about the values of a typical group member, but no accuracy in their attribution. The Estonian students (n = 152 avoided
    Eastern-European identification, while the Russian-speaking students (n = 54 did not want to give up Estonia’s Soviet past. We found that attributed rather than
    self-rated value differences between groups caused the conflicts, whilst diverging identities were found to make value stereotypes more extreme.

  2. Mental health and alcohol problems among Estonian cleanup workers 24 years after the Chernobyl accident.

    Science.gov (United States)

    Laidra, Kaia; Rahu, Kaja; Tekkel, Mare; Aluoja, Anu; Leinsalu, Mall

    2015-11-01

    To study the long-term mental health consequences of the 1986 Chernobyl nuclear accident among cleanup workers from Estonia. In 2010, 614 Estonian Chernobyl cleanup workers and 706 geographically and age-matched population-based controls completed a mail survey that included self-rated health, the Posttraumatic Stress Disorder Checklist (PCL), alcohol symptoms (AUDIT), and scales measuring depressive, anxiety, agoraphobia, fatigue, insomnia, and somatization symptoms. Respondents were dichotomized into high (top quartile) and low symptom groups on each measure. Logistic regression analysis detected significant differences between cleanup workers and controls on all measures even after adjustment for ethnicity, education, marital status, and employment status. The strongest difference was found for somatization, with cleanup workers being three times more likely than controls to score in the top quartile (OR = 3.28, 95% CI 2.39-4.52), whereas for alcohol problems the difference was half as large (OR = 1.52, 95% CI 1.16-1.99). Among cleanup workers, arrival at Chernobyl in 1986 (vs. later) was associated with sleep problems, somatization, and symptoms of agoraphobia. The toll of cleanup work was evident 24 years after the Chernobyl accident among Estonian cleanup workers indicating the need for focused mental health interventions.

  3. Groundwater flow model of the Estonian oil shale mining area towards to innovative system

    Energy Technology Data Exchange (ETDEWEB)

    Lind, H. [Tallinn Univ. of Technology (Estonia). Dept. of Mining

    2010-07-01

    Changes in the Estonian groundwater regime are anticipated as oil shale deposits are mined. This paper described a dynamic groundwater flow model used to develop a 3-D groundwater elevation map of the Estonian oil shale mining area. The model was used to provide preliminary estimations of water inflow into the working underground mine areas. The model included 9 closed underground mines, 5 active mine sites, and 2 small open-cast sites. The closed mine sites were filled with water flowing in from the working mine sites. New mines and dewatering programs are planned for the future. A database from observation wells installed within the Keila-Kukruse aquifer was used to extract outputs and determine time steps. The model included 35 pumping stations from the active mine sites. The hydraulic properties for each model layer were defined in 4 model zones. Results of the model showed higher water in-flows from the closed underground sites than earlier predictions had anticipated. 9 refs., 1 tab., 4 figs.

  4. Vene kirjandus venestusaja eesti koolides. Russian Literature in the Estonian Schools of the Russification Era

    Directory of Open Access Journals (Sweden)

    Ülle Pärli

    2012-04-01

    Full Text Available This article aims to give an overview of literary instruction in schools of the russification era at the beginning of the 20th century in Estonia; this was likewise the curriculum of literary study offered to the generation of educated youth which included the Young Estonians. Based on official documents, archival materials, and memoirs, and through analyses of anthologies, literary histories, and teaching methods in use at the time, we attempt to reconstruct the outlines of literary reading and requirements for students in various types of schools. When, as a result of school reform, Russian became the language of instruction; lessons in Russian became central in the curriculum, alongside the word of God; selections from Russian literature were read in the original language. In the lower grades, teaching was by the so-called ”natural method”, intended to guarantee swift achievement of fluency in ”living Russian language”; this was later replaced by systematic textual analysis, which distinguished between belles lettres and other types of texts. However, the study of literature was always subordinated to the goals of language instruction. In institutions of secondary education, study of Russian literature was separate from language instruction. Indeed, Russian literature was the only literature systematically studied in high schools (though one must keep in mind that not all schools completely followed the official program. Private schools were especially noticeable for their greater freedom, though all of them had to take general curriculum directives into account. Reading of literary texts connected with other languages thus had to remain almost purely illustrative. In view of the above, in the upper grades of elementary school and high school, students obtained a thorough introduction to the Russian classics. According to the official school curriculum, Russian literary history ended with Nikolai Gogol. Attempts were made to ignore

  5. Effects of assessing the productivity of faculty in academic medical centres: a systematic review

    Science.gov (United States)

    Akl, Elie A.; Meerpohl, Joerg J.; Raad, Dany; Piaggio, Giulia; Mattioni, Manlio; Paggi, Marco G.; Gurtner, Aymone; Mattarocci, Stefano; Tahir, Rizwan; Muti, Paola; Schünemann, Holger J.

    2012-01-01

    Background: Many academic medical centres have introduced strategies to assess the productivity of faculty as part of compensation schemes. We conducted a systematic review of the effects of such strategies on faculty productivity. Methods: We searched the MEDLINE, Healthstar, Embase and PsycInfo databases from their date of inception up to October 2011. We included studies that assessed academic productivity in clinical, research, teaching and administrative activities, as well as compensation, promotion processes and satisfaction. Results: Of 531 full-text articles assessed for eligibility, we included 9 articles reporting on eight studies. The introduction of strategies for assessing academic productivity as part of compensation schemes resulted in increases in clinical productivity (in six of six studies) in terms of clinical revenue, the work component of relative-value units (these units are nonmonetary standard units of measure used to indicate the value of services provided), patient satisfaction and other departmentally used standards. Increases in research productivity were noted (in five of six studies) in terms of funding and publications. There was no change in teaching productivity (in two of five studies) in terms of educational output. Such strategies also resulted in increases in compensation at both individual and group levels (in three studies), with two studies reporting a change in distribution of compensation in favour of junior faculty. None of the studies assessed effects on administrative productivity or promotion processes. The overall quality of evidence was low. Interpretation: Strategies introduced to assess productivity as part of a compensation scheme appeared to improve productivity in research activities and possibly improved clinical productivity, but they had no effect in the area of teaching. Compensation increased at both group and individual levels, particularly among junior faculty. Higher quality evidence about the benefits

  6. Regulatory analysis on the medical use of ephedrine-related products in Taiwan

    Directory of Open Access Journals (Sweden)

    Wan-Nan Yu

    2018-04-01

    Full Text Available To prevent ephedrine-related products from being misused to produce amphetamine and/or its analogs, there's a need for more effective and achievable regulatory mechanisms for the health, police, investigational, prosecution and judiciary authorities in Taiwan. This review was conducted to evaluate the international and Taiwan's regulatory policies and management of medical ephedrine-related products through the corresponding information collected from international and Taiwan government agency authorities. The combat of illegal drugs should involve both supply and demand sides to be successful. Health authorities in Taiwan do not have the investigational power to manage the forbidden transformation, abusing and manufacture of the illegal drugs from ephedrine-related products. Take the judicial interventions in the United States and in Japan as the examples, the organizational cooperation in Taiwan can be one of the main key strategies to combat against illegal drugs from ephedrine-related products. It is necessary to integrate the judicial, police and health agencies to prevent the production of illegal drugs from the ephedrine-related products in Taiwan. The efforts and regulatory control measures should be integrated to speed up the collaboration between different government authorities. It might be achieved through reorganization involving Taiwan Food and Drug Administration. Keywords: Ephedrine-related products, Taiwan Food and Drug Administration (TFDA, Controlled Drugs Act, Pharmaceutical Affairs Act, Pharmacists Act

  7. Choice of the irradiation dose for the sterilization of medical products

    International Nuclear Information System (INIS)

    Bochkarev, V.V.; Pavlov, E.P.; Sedov, V.V.; Khrushchev, V.G.; Tushov, Eh.G.; Konyaev, G.A.

    1975-01-01

    The principles for selecting the appropriate dose for the radiation sterilization of medical products are set forth, taking into account the initial contamination of the product, the radiation senstivity of contaminants and the required level of reliability of sterilization. The initial contamination level of certain preparations (glucose and radiopharmaceuticals) is established and the radiation sensitivity of the isolated contaminants is determined in terms of Dio indices. Of the microorganisms isolated the most common were staphylococci, streptococci, Gram-negative bacteria, Aspergilli, Penicillia and yeast fungi. Spore-forming types of microorganisms were isolated with a frequency of the order of 10 -2 . The radiation sensitivity in terms of D 10 was established for more than 3000 strains of microorganisms. For 75-85% of the strains the D 10 indices gave 10-40 krad and for 0.2-1% more than 100 krad. The experimental data were subjected to computer analysis which confirmed the adequacy of the techniques used to determine radiosensitivity. The authors then calculated by computer the radiation sterilizing doses for different degrees of initial contamination of the products with reliability coefficients of 10 6 and 10 8 . For sterilizing radiopharmaceuticals and glucose solutions these doses are 0.8-1 Mrad. Verification experiments show that these doses give reliable sterilization of the medical products concerned. (author)

  8. Scientific production of Vice Chancellors for Research in Peruvian universities with a medical school.

    Science.gov (United States)

    Herrera-Añazco, Percy; Valenzuela-Rodríguez, Germán; Pacheco-Mendoza, Josmel; Málaga, Germán

    2017-10-19

    To determine the scientific production of Research Vice-chancellors at Peruvian universities that have medical schools, as well as their academic degrees as an indirect way to evaluate their suitability for the position they hold. We searched all Peruvian universities that register medical schools. Of these, the scientific production of the universities registered in SCOPUS was identified in September of the 2016. The scientific production of the vice chancellors of investigation of these faculties of medicine was determined through the search of its scientific publications registered in SCOPUS and those reported in the National Registry of Researchers in Science and Technology. Academic degrees were obtained from the database of the National Superintendence of Higher University Education. The sample included 28 research vice chancellors. Only 4/28 had any publications. The average number of articles published by the vice chancellors of research was 1.71, the number of citations 23.1 on average and the H index 0.64. Besides, 22 Vice-chancellors of research had the degree of doctor, four had the degree of bachelor and two the degree of master. The scientific production of research vice chancellors is poor. The required academic grade requirement for the position is not met in all cases. It is likely that, having no research experience, his leadership in directing a university's research policies may be questioned.

  9. Increasing Therapist Productivity: Using Lean Principles in the Rehabilitation Department of an Academic Medical Center.

    Science.gov (United States)

    Johnson, Diana; Snedeker, Kristie; Swoboda, Michael; Zalieckas, Cheryl; Dorsey, Rachel; Nohe, Cassandra; Smith, Paige; Roche, Renuka

    The Department of Rehabilitation Services, within the University of Maryland Medical Center's 650-bed academic medical center, was experiencing difficulty in meeting productivity standards. Therapists in the outpatient division believed they were not spending enough time performing billable patient care activities. Therapists in the inpatient division had difficulty keeping pace with the volume of incoming referrals. Collectively, these issues caused dissatisfaction among referral sources and frustration among the staff within the rehabilitation department. The department undertook a phased approach to address these issues that included examining the evidence, using Lean process improvement principles, and employing transformational leadership strategies to drive improvements in productivity and efficiency. The lessons learned support the importance of having meaningful metrics appropriate for the patient population served, the use of Lean as an effective tool for improving productivity in rehabilitation departments, the impact of engaging staff at the grassroots level, and the importance of having commitment from leaders. The study findings have implications for not only rehabilitation and hospital leadership, but CEOs and managers of any business who need to eliminate waste or increase staff productivity.

  10. Medical application of nuclear science: nuclear medicine and production of radiopharmaceuticals

    International Nuclear Information System (INIS)

    Cornet, L.

    1997-01-01

    Nuclear science in attendance on medicine or from Radium to Radiopharmaceuticals. By a brief historical reminder of the evolution of the radioactivity and development of nuclear science, we could see a very early interest and application of the radioactivity in the medical field. Main steps: Detection of natural radioactivity/Discovery of artificial radioactivity/First treatment of leukaemia and thyroid/First nuclear reactor/First radioisotope laboratory in hospital/First scintigraphy/First radiopharmaceutical/First cyclotron and cyclotron products/First immunoscintigraphy/Biotechnology and radioisotope/Evolution of technics [equipment for diagnosis (imaging, scintigraphy) and therapy]/Evolution of production technics and concept of products (generators of Technetium) and machines, reactor, cyclotron/Evolution of importance and interest of nuclear medicine/Creation of international association of nuclear medicine and producers (example ARPR)/Evolution of safety and pharmaceuticals regulation. After the sixties, period extremely rich in invention of products, characterized by a high fertility specially due to a non-restrictive regulation in terms of safety and pharmaceutical consideration, the evolution of technics, the importance of costs (investment, research, healthcare and the evolution of the regulations) have smoothly but continuously transformed the contexts and different actors. Consequences and facts: Rationalization and standardization of the catalogues, total integration of radiopharmaceuticals into the pharmaceutical laws, stop of nuclear research reactors, increase of number of cyclotrons, transformation of size and role of the producers and nuclear centers, risk in supply of some raw materials like Molybdenum, medical nuclear application as a worldwide business

  11. Radioactive isotope production for medical applications using Kharkov electron driven subcritical assembly facility

    International Nuclear Information System (INIS)

    Talamo, A.; Gohar, Y.

    2007-01-01

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine has a plan to construct an accelerator driven subcritical assembly. The main functions of the subcritical assembly are the medical isotope production, neutron thereby, and the support of the Ukraine nuclear industry. Reactor physics experiments and material research will be carried out using the capabilities of this facility. The United States of America and Ukraine have started collaboration activity for developing a conceptual design for this facility with low enrichment uranium (LEU) fuel. Different conceptual designs are being developed based on the facility mission and the engineering requirements including nuclear physics, neutronics, heat transfer, thermal hydraulics, structure, and material issues. Different fuel designs with LEU and reflector materials are considered in the design process. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements and upgrades. This report is a part of the Argonne National Laboratory Activity within this collaboration for developing and characterizing the subcritical assembly conceptual design. In this study, the medical isotope production function of the Kharkov facility is defined. First, a review was carried out to identify the medical isotopes and its medical use. Then a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Finally, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and irradiation location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes were considered and all transmutation channels are used including (n,γ), (n,2n), (n,p), and (γ,n). In the second part, the parent

  12. Radioactive isotope production for medical applications using Kharkov electron driven subcritical assembly facility.

    Energy Technology Data Exchange (ETDEWEB)

    Talamo, A.; Gohar, Y.; Nuclear Engineering Division

    2007-05-15

    Kharkov Institute of Physics and Technology (KIPT) of Ukraine has a plan to construct an accelerator driven subcritical assembly. The main functions of the subcritical assembly are the medical isotope production, neutron thereby, and the support of the Ukraine nuclear industry. Reactor physics experiments and material research will be carried out using the capabilities of this facility. The United States of America and Ukraine have started collaboration activity for developing a conceptual design for this facility with low enrichment uranium (LEU) fuel. Different conceptual designs are being developed based on the facility mission and the engineering requirements including nuclear physics, neutronics, heat transfer, thermal hydraulics, structure, and material issues. Different fuel designs with LEU and reflector materials are considered in the design process. Safety, reliability, and environmental considerations are included in the facility conceptual design. The facility is configured to accommodate future design improvements and upgrades. This report is a part of the Argonne National Laboratory Activity within this collaboration for developing and characterizing the subcritical assembly conceptual design. In this study, the medical isotope production function of the Kharkov facility is defined. First, a review was carried out to identify the medical isotopes and its medical use. Then a preliminary assessment was performed without including the self-shielding effect of the irradiated samples. Finally, more detailed investigation was carried out including the self-shielding effect, which defined the sample size and irradiation location for producing each medical isotope. In the first part, the reaction rates were calculated as the multiplication of the cross section with the unperturbed neutron flux of the facility. Over fifty isotopes were considered and all transmutation channels are used including (n,{gamma}), (n,2n), (n,p), and ({gamma},n). In the second part

  13. Stages of Dairy Products Consumption Change by Medical Students: The Trans Theoretical Model

    Directory of Open Access Journals (Sweden)

    N. Kholdi

    2013-02-01

    Full Text Available Background and Objective: In spite of the reverse relationship between Dairy products consumption and chronic diseases, the university students do not consume enough amounts of dairy products. Success interventions for changing dairy consumption patterns need to determine its stages of change. Determining medical students’ readiness to change the dairy consumption pattern through stages of change was the aim of this study. Methods: For this descriptive analytical cross-sectional study, 404 medical students were selected by random clustered sampling. The food frequency and stages of change questionnaires were used to get data. The relationship between age, sex, body mass index, settlement situation, marriage situation and educational STATUS with dairy consumption stages of change were analyzed by chi-2, Kruskal-wallis, Spearman correlation and logistic regression. Results: Less than 50% of students (40% females and 46% males consumed enough servings of dairy products daily. The servings of dairy consumption had not relation with sex, marriage or settlement status, age and body mass index. The least number of students (12.6% were in precontemplation and 26% in contemplation, 18.8% in preparation, and 24.8 and 17.8% in action and maintenance stages. While there was relationship between educational status and stages of change, such a relation had not been found between other variables and stages of change. The percent of internship students in action and maintenance stages were greater than students in medical basic sciences (OR=1.7. Conclusion: Regards to students’ inadequate amount and inappropriate kind of dairy products consumption and readiness to change dairy consumption in about half of students, it seems necessary to apply appropriate intervention strategies on the basis of stages of change to correct dairy consumption patterns.

  14. Medical and biomedical research productivity from the Kingdom of Saudi Arabia (2008-2012

    Directory of Open Access Journals (Sweden)

    Rabia Latif

    2015-01-01

    Full Text Available Background: Biomedical publications from a country mirror the standard of Medical Education and practice in that country. It is important that the performance of the health profession is occasionally documented. Aims: This study aimed to analyze the quantity and quality of biomedical publications from the Kingdom of Saudi Arabia (KSA in international journals indexed in PubMed between 2008 and 2012. Materials and Methods: PubMed was searched for publications associated with KSA from 2008 to 2012. The search was limited to medical and biomedical subjects. Results were saved in a text file and later checked carefully to exclude false positive errors. The quality of the publication was assessed using Journal Citation Report 2012. Results: Biomedical research production in KSA in those 5 years showed a clear linear progression. Riyadh was the main hub of medical and biomedical research activity. Most of the publications (40.9% originated from King Saud University (KSU. About half of the articles were published in journals with an Impact Factor (IF of < 1, one-fourth in journals with no IF, and the remaining one-fourth in journals with a high IF (≥1. Conclusion: This study revealed that research activity in KSA is increasing. However, there is an increasing trend of publishing in local journals with a low IF. More effort is required to promote medical research in Saudi Arabia.

  15. Off-label use of medical products in radiation therapy: Summary of the Report of AAPM Task Group No. 121

    International Nuclear Information System (INIS)

    Thomadsen, Bruce R.; Thompson, Heaton H. II; Jani, Shirish K.

    2010-01-01

    Medical products (devices, drugs, or biologics) contain information in their labeling regarding the manner in which the manufacturer has determined that the products can be used in a safe and effective manner. The Food and Drug Administration (FDA) approves medical products for use for these specific indications which are part of the medical product's labeling. When medical products are used in a manner not specified in the labeling, it is commonly referred to as off-label use. The practice of medicine allows for this off-label use to treat individual patients, but the ethical and legal implications for such unapproved use can be confusing. Although the responsibility and, ultimately, the liability for off-label use often rests with the prescribing physician, medical physicists and others are also responsible for the safe and proper use of the medical products. When these products are used for purposes other than which they were approved, it is important for medical physicists to understand their responsibilities. In the United States, medical products can only be marketed if officially cleared, approved, or licensed by the FDA; they can be used if they are not subject to or specifically exempt from FDA regulations, or if they are being used in research with the appropriate regulatory safeguards. Medical devices are either cleared or approved by FDA's Center for Devices and Radiological Health. Drugs are approved by FDA's Center for Drug Evaluation and Research, and biological products such as vaccines or blood are licensed under a biologics license agreement by FDA's Center for Biologics Evaluation and Research. For the purpose of this report, the process by which the FDA eventually clears, approves, or licenses such products for marketing in the United States will be referred to as approval. This report summarizes the various ways medical products, primarily medical devices, can legally be brought to market in the United States, and includes a discussion of the

  16. Medical Radioisotope Production in a Power-Flattened ADS Fuelled with Uranium and Plutonium Dioxides

    Directory of Open Access Journals (Sweden)

    Gizem Bakır

    2016-01-01

    Full Text Available This study presents the medical radioisotope production performance of a conceptual accelerator driven system (ADS. Lead-bismuth eutectic (LBE is selected as target material. The subcritical fuel core is conceptually divided into ten equidistant subzones. The ceramic (natural U, PuO2 fuel mixture and the materials used for radioisotope production (copper, gold, cobalt, holmium, rhenium, thulium, mercury, palladium, thallium, molybdenum, and yttrium are separately prepared as cylindrical rods cladded with carbon/carbon composite (C/C and these rods are located in the subzones. In order to obtain the flattened power density, percentages of PuO2 in the mixture of UO2 and PuO2 in the subzones are adjusted in radial direction of the fuel zone. Time-dependent calculations are performed at 1000 MW thermal fission power (Pth for one hour using the BURN card. The neutronic results show that the investigated ADS has a high neutronic capability, in terms of medical radioisotope productions, spent fuel transmutation and energy multiplication. Moreover, a good quasiuniform power density is achieved in each material case. The peak-to-average fission power density ratio is in the range of 1.02–1.28.

  17. Re-conceptualizing mother tongue tuition of Estonian abroad as a transnational phenomenon

    Directory of Open Access Journals (Sweden)

    Maarja Siiner

    2017-05-01

    Full Text Available The governmental initiative called the Compatriots Programme, which supports language tuition in Estonian schools and societies abroad, reveals an increased interest in developing intergenerational language transmission in the growing Estonian diaspora. This transnational language political activity signals a new era in language policy, where nation states are increasingly decentralized by migration. The evaluation of the program furthermore reveals that organizing such schools requires a willingness to take language political agency, typically conducted by well-educated and well-integrated resourceful transnational multilingual parents. The present article outlines the results of an ethnographic study of the process of establishing the Estonian School in Copenhagen. This step has demanded a change in the mindset still prevailing in Estonia that language political activities, such as planning language acquisition, are solely the responsibility of the state. Since the prevailing language ideology in Denmark is not favorable towards multilingualism in migrant languages, intergenerational language transmission furthermore presupposes a feeling of ownership of the language and high language self-esteem. "Hargmaise keelepoliitika sünd. Eesti keeleõppe korraldamise võimalikkusest välismaal Taani näitel" Hargmaisus, kasvav väljarändajate arv ja sellega ka eesti keele rääkijate hulk välismaal on jätnud oma jälje eesti keelepoliitikale. Kui varem uuriti peamiselt seda, kuidas eesti keel muukeelses kontekstis muutub, siis viimasel kümnendil on riik asunud aktiivselt toetama eesti keele jätkuvat kasutamist välismaal, rahastades rahvuskaaslaste programmi abil haridusprogramme. Kuid millised faktorid määravad selle, kas uus eestlaste põlvkond oskab ja tahab eesti keelt rääkida? Artikkel hindab etnograafilises ja sotsiolingvistilises võtmes Kopenhaagenis kolm aastat tegutsenud Eesti Kooli ja Lasteklubi näitel, millised on keelekasutust

  18. Implementation of medical scribes in an academic urology practice: an analysis of productivity, revenue, and satisfaction.

    Science.gov (United States)

    McCormick, Benjamin J; Deal, Allison; Borawski, Kristy M; Raynor, Mathew C; Viprakasit, Davis; Wallen, Eric M; Woods, Michael E; Pruthi, Raj S

    2018-04-10

    Pressure on physicians to increase productivity is rising in parallel with administrative tasks, regulations, and the use of electronic health records (EHRs). Physician extenders and clinical pathways are already in use to increase productivity and reduce costs and burnout, but other strategies are required. We evaluated whether implementation of medical scribes in an academic urology clinic would affect productivity, revenue, and patient/provider satisfaction. Six academic urologists were assigned scribes for 1 clinic day per week for 3 months. Likert-type patient and provider surveys were developed to evaluate satisfaction with and without scribes. Matched clinic days in the year prior were used to evaluate changes in productivity and physician/hospital charges and revenue. After using scribes for 3 months, providers reported increased efficiency (p value = 0.03) and work satisfaction (p value = 0.03), while seeing a mean 2.15 more patients per session (+ 0.96 return visits, + 0.99 new patients, and + 0.22 procedures), contributing to an additional 2.6 wRVUs, $542 in physician charges, and $861 in hospital charges per clinic session. At a gross collection rate of 36%, actual combined revenue was + $506/session, representing a 26% increase in overall revenue. At a cost of $77/session, the net financial impact was + $429 per clinic session, resulting in a return-to-investment ratio greater than 6:1, while having no effect on patient satisfaction scores. Additionally, with scribes, clinic encounters were closed a mean 8.9 days earlier. Implementing medical scribes in academic urology practices may be useful in increasing productivity, revenue, and provider satisfaction, while maintaining high patient satisfaction.

  19. Estimation of radiation dose rates around medical isotopes production facility of Cyclotron

    International Nuclear Information System (INIS)

    Srihari, K.; Bandyopadhyay, Tapas; Saha, Subimal; Das, M.K.

    2015-01-01

    The demand of the radio isotopes for medical application is increasing day by day. Cyclotron is a tool for production of these proton rich isotopes which are termed a SPECT and PET isotopes. The irradiated hot targets from a cyclotron bunker are transferred to the hot cells for processing chemically to obtain the required radioisotope. A pre estimation of dose rates at various locations of the hot cells with worst and normal operation conditions is essential. An exercise of estimation of worst cases also gives an idea about the dose to the workers and necessary preparedness without compromising on the regulatory aspects. 18 F, 67 Ga, 201 Tl are the most important isotopes that will be produced in medical cyclotron. They are produced by bombarding proton on suitable target materials. The activated targets transferred to the hot cells from irradiated machine/production bunker. Chemist has to work at hot cells for chemical synthesis for 18 F to form FDG. For SPECT isotope production target has to under go two stages of chemical synthesis. The dose rate estimation around the hot cells will give the estimation of dose to the radiation workers. In addition to medical isotope the other materials surrounding the target also get activated because of proton or neutron activation. The dose estimation depends on the total activity that is produced and the period of time for entire the chemical processing. The dose rate are estimated by using suitable expressions considering normal and worst scenario conditions. A procedure and a case was discussed and result shown both for normal and worse scenario case. It is observed that not only shielding many other factors like ventilation etc played important role. A case study was made and results are shown with the suggestive preventive measures. (author)

  20. Neutronic and thermal-hydraulic studies of aqueous homogeneous reactor for medical isotopes production

    Energy Technology Data Exchange (ETDEWEB)

    Perez, Daniel Milian; Lorenzo, Daniel E. Milian; Lira, Carlos A. Brayner de Oliveira; Garcia, Lorena P. Rodríguez, E-mail: milianperez89@gmail.com, E-mail: dmilian@instec.cu, E-mail: lorenapilar1109@gmail.com, E-mail: cabol@ufpe.br [Higher Institute of Technologies and Applied Sciences (InSTEC), Havana (Cuba); Universidade Federal de Pernambuco (UFPE), Recife, PE (Brazil). Departamento de Energia Nuclear

    2017-11-01

    The use of Aqueous Homogenous Reactors (AHR) is one of the most promissory alternatives to produce medical isotopes, mainly {sup 99}Mo. Compare to multipurpose research reactors, an AHR dedicated for {sup 99}Mo production has advantages because of their low cost, small critical mass, inherent passive safety, and simplified fuel handling, processing, and purification characteristics. This article presents the current state of research in our working group on this topic. Are presented and discussed the group validation efforts with benchmarking exercises that include neutronic and thermal-hydraulic results of two solution reactors, the SUPO and ARGUS reactors. Neutronic and thermal-hydraulic results of 75 kWth AHR based on the ARGUS reactor LEU configuration are presented. The neutronic studies included the determination of parameters such as reflector thickness, critical height, medical isotopes production and others. Thermal-hydraulics studies were focused on demonstrating that sufficient cooling capacity exists to prevent fuel overheating. In addition, the effects of some calculation parameters on the computational modeling of temperature, velocity and gas volume fraction during steady-state operation of an AHR are discussed. The neutronic and thermal-hydraulics studies have been performed with the MCNPX version 2.6e computational code and the version 14 of ANSYS CFX respectively. Our group studies and the results obtained contribute to demonstrate the feasibility of using AHR for the production of medical isotopes, however additional studies are still necessary to confirm these results and contribute to development and demonstration of their technical, safety, and economic viability. (author)

  1. Potential medical applications of the plasma focus in the radioisotope production for PET imaging

    International Nuclear Information System (INIS)

    Roshan, M.V.; Razaghi, S.; Asghari, F.; Rawat, R.S.; Springham, S.V.; Lee, P.; Lee, S.; Tan, T.L.

    2014-01-01

    Devices other than the accelerators are desired to be investigated for generating high energy particles to induce nuclear reaction and positron emission tomography (PET) producing radioisotopes. The experimental data of plasma focus devices (PF) are studied and the activity scaling law for External Solid Target (EST) activation is established. Based on the scaling law and the techniques to enhance the radioisotopes production, the feasibility of generating the required activity for PET imaging is studied. - Highlights: • Short lived radioisotopes for PET imaging are produced in plasma focus device. • The scaling law of the activity induced with plasma focus energy is established. • The potential medical applications of plasma focus are studied

  2. Considerations in the design of a high power medical isotope production reactor

    International Nuclear Information System (INIS)

    Ball, Russell M.; Nordyke, William H.; Brown, Roy

    2002-01-01

    For the low enriched aqueous homogeneous reactor to be economic in the production of medical isotopes, such as Mo-99 and Sr-89, the power level should be of the order of 100 kWth. This is double the earlier designs and this paper discusses the design changes which must be considered to meet this goal. The topics considered are: 1. Heat removal from the reactor solution; 2. Recombination of radiolytic gases; 3. Adequate radiation shielding; 4. Stability of reactor power with fluctuating reactivity; 5. Adequate cooling of the reflector; 6. Independent shutdown mechanisms; 7. Required volume of the reactor; 8. Economic implementation. (author)

  3. Characterization and Utilization of castor bean seed oil extract for production of medicated soap.

    OpenAIRE

    Abdulrasheed A; Aroke U. O; Muazu M.T.

    2015-01-01

    The research work is to investigate the potential utilization of castor bean seed oil extract in the production of medicated soap. The oil was extracted via soxhlet extractor using hexane as solvent. The characterization analysis reveals the acid value and saponification value of the oil which were between the ranges of values specified by ASTM. The soap produced gave a pH of (8.9), foam height (16cm), alcohol insoluble (3.45%), moisture content (4.2%) and free acidity of (0.10). The antibact...

  4. Residual Isocyanates in Medical Devices and Products: A Qualitative and Quantitative Assessment

    Directory of Open Access Journals (Sweden)

    Gillian Franklin

    2016-01-01

    Full Text Available We conducted a pilot qualitative and quantitative assessment of residual isocyanates and their potential initial exposures in neonates, as little is known about their contact effect. After a neonatal intensive care unit (NICU stockroom inventory, polyurethane (PU and PU foam (PUF devices and products were qualitatively evaluated for residual isocyanates using Surface SWYPE ™ . Those containing isocyanates were quantitatively tested for methylene diphenyl diisocyanate (MDI species, using UPLC-UV-MS/MS method. Ten of 37 products and devices tested, indicated both free and bound residual surface isocyanates; PU/PUF pieces contained aromatic isocyanates; one product contained aliphatic isocyanates. Overall, quantified mean MDI concentrations were low (4,4‘-MDI = 0.52 to 140.1 pg/mg and (2,4‘-MDI = 0.01 to 4.48 pg/mg. The 4,4‘-MDI species had the highest measured concentration (280 pg/mg. Commonly used medical devices/products contain low, but measurable concentrations of residual isocyanates. Quantifying other isocyanate species and neonatal skin exposure to isocyanates from these devices and products requires further investigation.

  5. Current pulse: can a production system reduce medical errors in health care?

    Science.gov (United States)

    Printezis, Antonios; Gopalakrishnan, Mohan

    2007-01-01

    One of the reasons for rising health care costs is medical errors, a majority of which result from faulty systems and processes. Health care in the past has used process-based initiatives such as Total Quality Management, Continuous Quality Improvement, and Six Sigma to reduce errors. These initiatives to redesign health care, reduce errors, and improve overall efficiency and customer satisfaction have had moderate success. Current trend is to apply the successful Toyota Production System (TPS) to health care since its organizing principles have led to tremendous improvement in productivity and quality for Toyota and other businesses that have adapted them. This article presents insights on the effectiveness of TPS principles in health care and the challenges that lie ahead in successfully integrating this approach with other quality initiatives.

  6. Grammar School Students’ Opinions on the Art Curriculum: An Estonian, Portuguese and Slovenian Comparative Study

    Directory of Open Access Journals (Sweden)

    Tomaž Zupančič

    2015-09-01

    Full Text Available The article presents the attitude of grammar school students towards the art curriculum. It first provides an overview of the characteristics of contemporary art education, with an emphasis on the postmodern art curriculum and on linking course content with students’ interests. The study is based on the descriptive and causal non-experimental method, with a sample comprising 387 Slovenian, Estonian and Portuguese students. It was established that the students place the highest value on developing creativity, and are less interested in art history content and learning about the basics of the formal art language. They are attracted to contemporary topics, such as graffiti, multicultural art, the use of new media, and digital technologies. The results of the study provide opportunities for future comparative analyses and starting points for updating art curricula.

  7. Role of fatty acids in the formation of Estonian oil shale (kukersite)

    Energy Technology Data Exchange (ETDEWEB)

    Klesment, I.

    1973-01-01

    Study of the composition of the tar from semicoking of Estonian kukersite, by separation and chromatographic and spectroscopic analysis, showed that approximately 40 percent of the carbon of the bituminous material existed as linear chains. At the beginning of fossilization the original biological material for the formation of the kerogen of the kukersite (saturated and unsaturated fatty acids C/sub 14/-C/sub 18/) was oxidized at the double bonds of the unsaturated acids, and carbonyl and ..beta..-polycarbonyl groups were formed. During pyrolysis of the polycarbonyl chains, alkylresorcinols were formed containing linear alkyl chains with less than or equal to 10 carbon atoms. The phenols, boiling at 280/sup 0/-430/sup 0/C, have a much higher alkylresorcinols content than those obtained during semicoking of other solid fuels.

  8. Comparative analysis of idiom selection and sequencing 5 in Estonian basic school EFL coursebooks

    Directory of Open Access Journals (Sweden)

    Rita Anita Forssten

    2017-05-01

    Full Text Available The article investigates the selection and sequencing of the idioms encountered in two locally-produced and international coursebook series currently employed in Estonian basic schools. It is hypothesized that there exists a positive correlation between idioms’ difficulty and coursebooks’ language proficiency level. The hypothesis is tested through a statistical analysis of the idioms found which are categorized in terms of their analysability into three categories where category 1 includes analysable semi-literal idioms, category 2 comprises analysable semi-transparent idioms, and category 3 encompasses non-analysable opaque idioms, and then analysed through an online language corpus (British National Corpus. The results of the study reveal that the coursebook authors under discussion have disregarded idioms’ frequency as a criterion for selection or sequencing, whereas the factor utilized to some extent is the degree of analysability.

  9. Whole-word frequency and inflectional paradigm size facilitate Estonian case-inflected noun processing.

    Science.gov (United States)

    Lõo, Kaidi; Järvikivi, Juhani; Baayen, R Harald

    2018-06-01

    Estonian is a morphologically rich Finno-Ugric language with nominal paradigms that have at least 28 different inflected forms but sometimes more than 40. For languages with rich inflection, it has been argued that whole-word frequency, as a diagnostic of whole-word representations, should not be predictive for lexical processing. We report a lexical decision experiment, showing that response latencies decrease both with frequency of the inflected form and its inflectional paradigm size. Inflectional paradigm size was also predictive of semantic categorization, indicating it is a semantic effect, similar to the morphological family size effect. These findings fit well with the evidence for frequency effects of word n-grams in languages with little inflectional morphology, such as English. Apparently, the amount of information on word use in the mental lexicon is substantially larger than was previously thought. Copyright © 2018 Elsevier B.V. All rights reserved.

  10. Performance curves of medical researchers during their career: analysis of scientific production from a retrospective cohort.

    Science.gov (United States)

    Duclos, Antoine; Herquelot, Eléonore; Polazzi, Stéphanie; Malbezin, Muriel; Claris, Olivier

    2017-02-24

    To establish the pattern of change in individual scientific production over the career of medical researchers. Retrospective cohort based on prospectively collected data in a hospital information system. Multicentre university hospital in France. Two distinct populations of 1835 researchers (full professors vs non-academic physicians) having produced 44 723 publications between 1995 and 2014. Annual number of publications referenced in Medline/PubMed with a sensitivity analysis based on publications as first/last author and in high impact journals. The individual volume of publications was modelled by age using generalised estimating equations adjusted for birth cohort, biomedical discipline and academic position of researchers. Averaged over the whole career, the annual number of publications was 5.28 (95% CI 4.90 to 5.69) among professors compared to 0.82 (95% CI 0.76 to 0.89) among non-academic physicians (pscientific production between 25 and 35 years (adjusted incidence rate ratio 102.20, 95% CI 60.99 to 171.30), a maturation phase with a slower increase from 35 to 50 years (2.10, 95% CI 1.75 to 2.51) until a stabilisation phase with constant production followed by a potential decline at the end of career (0.90, 95% CI 0.77 to 1.06). The non-academic physicians experienced a slower pace of learning curve at the beginning of their careers (42.38, 95% CI 25.37 to 70.81) followed by a smaller increase in the annual number of publications (1.29, 95% CI 1.11 to 1.51). Compared to full professors, non-academic physicians had a poor capacity to publish, indicating a low productivity when medical doctors have limited time or little interest in undertaking research. This finding highlights the potential for rethinking the missions of medical doctors towards an enlargement of scientific prerogatives in favour of progress in global knowledge. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go

  11. Compatibility of polymeric materials with the radiosterilization of disposable medical products

    International Nuclear Information System (INIS)

    Gonzalez, M.E.

    1990-01-01

    The semiindustrial plant of irradiation located at the Atomic Center of Ezeiza entered into operation 20 years ago. This plant has a nominal activity of 3.7 x 10 16 Bq (10 6 Ci) and is presently operating with 1.78 x 10 16 Bq (4.8 x 10 5 Ci). The facility allows working in pilot plant scale for the study of industrial applications and also performs commercial services, the most important of which considering its volume, economic significance and social function is the radiosterilization of disposable medical products. Approximately 29,000 m 3 have been processed in this period, most of the materials being polymers, as component parts of the products as well as packaging. To validate the process of radiosterilization the materials compatibility with ionizing radiation must be known. In the department that operates the irradiation plant, the polymer laboratory is involved in the development of industrial applications and also in the subject of compatibility of polymers with radiosterilization. The laboratory gives advice on request about selection of materials as well as relevant information for the evaluation of radiation resistance and stability, including exposition doses for the samples and mechanical, physical or chemical tests according to the kind of product. In many occasions this laboratory has had to undertake these tests because local manufacturers of medical products not always have adequate facilities for quality control. Among mechanical tests the area under the stress-strain curve as a measure of the strain the material can undergo without fracture is perhaps the best for the evaluation of degradation. Among physical properties it is important to evaluate discoloration, usual in plastics irradiation, and concerning chemical tests the detection of migration of components from the polymer proves important in some cases. Although the irradiator cannot assume any responsibility concerning compatibility, local experience has shown the importance of having a

  12. Blood Product Utilization Among Trauma and Nontrauma Massive Transfusion Protocols at an Urban Academic Medical Center.

    Science.gov (United States)

    Patel, Eshan U; Ness, Paul M; Marshall, Christi E; Gniadek, Thomas; Efron, David T; Miller, Peter M; Zeitouni, Joseph A; King, Karen E; Bloch, Evan M; Tobian, Aaron A R

    2017-09-01

    Hospital-wide massive transfusion protocols (MTPs) primarily designed for trauma patients may lead to excess blood products being prepared for nontrauma patients. This study characterized blood product utilization among distinct trauma and nontrauma MTPs at a large, urban academic medical center. A retrospective study of blood product utilization was conducted in patients who required an MTP activation between January 2011 and December 2015 at an urban academic medical center. Trauma MTP containers included 6 red blood cell (RBC) units, 5 plasma units, and 1 unit of apheresis platelets. Nontrauma MTP containers included 6 RBC and 3 plasma units. There were 334 trauma MTP activations, 233 nontrauma MTP activations, and 77 nontrauma MTP activations that subsequently switched to a trauma MTP ("switched activations"). All nontrauma MTP activations were among bleeding patients who did not have a traumatic injury (100% [233/233]). Few patients with a nontrauma activation required ad hoc transfusion of RBC units (1.3% [95% confidence interval {CI}, 0.3%-3.7%]) or plasma (3.4% [95% CI, 1.5%-6.7%]), and only 45.5% (95% CI, 39.0%-52.1%) required ad hoc transfusion of apheresis platelets. Compared to trauma and switched activations, nontrauma activations transfused a lower median number of RBC, plasma, and apheresis platelet units (P use of hospital-wide nontrauma MTPs are warranted since an MTP designed for nontrauma patient populations may yield a key strategy to optimize blood product utilization in comparison to a universal MTP for both trauma and nontrauma patients.

  13. Chromosomal microarray analysis as a first-tier clinical diagnostic test: Estonian experience.

    Science.gov (United States)

    Zilina, Olga; Teek, Rita; Tammur, Pille; Kuuse, Kati; Yakoreva, Maria; Vaidla, Eve; Mölter-Väär, Triin; Reimand, Tiia; Kurg, Ants; Ounap, Katrin

    2014-03-01

    Chromosomal microarray analysis (CMA) is now established as the first-tier cytogenetic diagnostic test for fast and accurate detection of chromosomal abnormalities in patients with developmental delay/intellectual disability (DD/ID), multiple congenital anomalies (MCA), and autism spectrum disorders (ASD). We present our experience with using CMA for postnatal and prenatal diagnosis in Estonian patients during 2009-2012. Since 2011, CMA is on the official service list of the Estonian Health Insurance Fund and is performed as the first-tier cytogenetic test for patients with DD/ID, MCA or ASD. A total of 1191 patients were analyzed, including postnatal (1072 [90%] patients and 59 [5%] family members) and prenatal referrals (60 [5%] fetuses). Abnormal results were reported in 298 (25%) patients, with a total of 351 findings (1-3 per individual): 147 (42%) deletions, 106 (30%) duplications, 89 (25%) long contiguous stretches of homozygosity (LCSH) events (>5 Mb), and nine (3%) aneuploidies. Of all findings, 143 (41%) were defined as pathogenic or likely pathogenic; for another 143 findings (41%), most of which were LCSH, the clinical significance remained unknown, while 61 (18%) reported findings can now be reclassified as benign or likely benign. Clinically relevant findings were detected in 126 (11%) patients. However, the proportion of variants of unknown clinical significance was quite high (41% of all findings). It seems that our ability to detect chromosomal abnormalities has far outpaced our ability to understand their role in disease. Thus, the interpretation of CMA findings remains a rather difficult task requiring a close collaboration between clinicians and cytogeneticists.

  14. Abatement of xenon and iodine emissions from medical isotope production facilities.

    Science.gov (United States)

    Doll, Charles G; Sorensen, Christina M; Bowyer, Theodore W; Friese, Judah I; Hayes, James C; Hoffmann, Emmy; Kephart, Rosara

    2014-04-01

    The capability of the International Monitoring System (IMS) to detect xenon from underground nuclear explosions is dependent on the radioactive xenon background. Adding to the background, medical isotope production (MIP) by fission releases several important xenon isotopes including xenon-133 and iodine-133 that decays to xenon-133. The amount of xenon released from these facilities may be equivalent to or exceed that released from an underground nuclear explosion. Thus the release of gaseous fission products within days of irradiation makes it difficult to distinguish MIP emissions from a nuclear explosion. In addition, recent shortages in molybdenum-99 have created interest and investment opportunities to design and build new MIP facilities in the United States and throughout the world. Due to the potential increase in the number of MIP facilities, a discussion of abatement technologies provides insight into how the problem of emission control from MIP facilities can be tackled. A review of practices is provided to delineate methods useful for abatement of medical isotopes. Published by Elsevier Ltd.

  15. Guidelines for industrial radiation sterilization of disposable medical products (Cobalt-60 gamma irradiation)

    International Nuclear Information System (INIS)

    1990-01-01

    This IAEA document is aimed at providing necessary guidance on standards and criteria and assistance to Member States, particularly developing countries, in their attempts to properly set up facilities for industrial radiation sterilization of duly-manufactured medical products by exposure to Co-60 gamma radiation. The contents of the guidelines have therefore been designed, as far as practicable, to reflect the practices and procedures currently employed in the processing of the majority of the radiation-sterilized medical products being produced worldwide. Consequently, this document has attempted to present to its users, for information and for action, all the relevant features of the standard criteria as are currently in existence under the auspices of the various authoritative national and/or regional Codes or Guides. The potential user(s) from Member States are expected to freely decide which of the various standards as enumerated in the Guidelines document should be considered for inclusion or exclusion either partially or totally in the context of the formulation of their own nationally-acceptable guidelines. Refs and tabs

  16. Uses of alpha particles, especially in nuclear reaction studies and medical radionuclide production

    Energy Technology Data Exchange (ETDEWEB)

    Qaim, Syed M.; Spahn, Ingo; Scholten, Bernhard; Neumaier, Bernd [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Neurowissenschaften und Medizin (INM), Nuklearchemie (INM-5)

    2016-11-01

    Alpha particles exhibit three important characteristics: scattering, ionisation and activation. This article briefly discusses those properties and outlines their major applications. Among others, α-particles are used in elemental analysis, investigation and improvement of materials properties, nuclear reaction studies and medical radionuclide production. The latter two topics, dealing with activation of target materials, are treated in some detail in this paper. Measurements of excitation functions of α-particle induced reactions shed some light on their reaction mechanisms, and studies of isomeric cross sections reveal the probability of population of high-spin nuclear levels. Regarding medical radionuclides, an overview is presented of the isotopes commonly produced using α-particle beams. Consideration is also given to some routes which could be potentially useful for production of a few other radionuclides. The significance of α-particle induced reactions to produce a few high-spin isomeric states, decaying by emission of low-energy conversion or Auger electrons, which are of interest in localized internal radiotherapy, is outlined. The α-particle beam, thus broadens the scope of nuclear chemistry research related to development of non-standard positron emitters and therapeutic radionuclides.

  17. High-precision gamma-ray spectroscopy for enhancing production and application of medical isotopes

    Science.gov (United States)

    McCutchan, E. A.; Sonzogni, A. A.; Smith, S. V.; Muench, L.; Nino, M.; Greene, J. P.; Carpenter, M. P.; Zhu, S.; Chillery, T.; Chowdhury, P.; Harding, R.; Lister, C. J.

    2015-10-01

    Nuclear medicine is a field which requires precise decay data for use in planning radionuclide production and in imaging and therapeutic applications. To address deficiencies in decay data, sources of medical isotopes were produced and purified at the Brookhaven Linear Isotope Producer (BLIP) then shipped to Argonne National Laboratory where high-precision, gamma-ray measurements were performed using Gammasphere. New decay schemes for a number of PET isotopes and the impact on dose calculations will be presented. To investigate the production of next-generation theranostic or radiotherapeutic isotopes, cross section measurements with high energy protons have also been explored at BLIP. The 100-200 MeV proton energy regime is relatively unexplored for isotope production, thus offering high discovery potential but at the same time a challenging analysis due to the large number of open channels at these energies. Results of cross sections deduced from Compton-suppressed, coincidence gamma-ray spectroscopy performed at Lowell will be presented, focusing on the production of platinum isotopes by irradiating natural platinum foils with 100 to 200 MeV protons. DOE Isotope Program is acknowledged for funding ST5001030. Work supported by the US DOE under Grant DE-FG02-94ER40848 and Contracts DE-AC02-98CH10946 and DE-AC02-06CH11357.

  18. Study of alternative routes for the production of innovative radionuclides for medical applications

    International Nuclear Information System (INIS)

    Duchemin, Charlotte

    2015-01-01

    Nuclear medicine is a specialty that uses radioactive nuclei for therapy or diagnosis of diseases such as different types of cancer. These radionuclides are coupled to carrier molecules to target sick cells. Currently, only few isotopes are used in clinical practice. However, many others may be of medical interest due to their emitted radiation and/or their half-life that can be adapted to the carrier molecule transit time and to the pathology. The aim of this PhD thesis is to study the production of innovative radionuclides for therapy and diagnosis applications in collaboration with the GIP ARRONAX, which possesses a multi-particle high energy cyclotron. A fundamental physical parameter to access the production rate of a radionuclide is the production cross section. Experimental data were measured for a selection of radionuclides: photon emitter (Tc-99m) and positron emitter (Sc-44g) for diagnosis, as well as electron emitters (Re-186, Tb-155 and Sn-117m) and α particles emitters (Th-226, Ra-223 and Bi-213) for therapeutic applications. These acquired data are obtained using alternative production routes compared to the commonly used. Data related to the contaminants produced during the irradiations were also extracted. The experimental cross section values are compared with theoretical model predictions. The large set of data obtained contributes to the theoretical physicist studies allowing to constrain their models to improve and/or validate them. (author)

  19. Legal regulation of the production and trade of medical devices and medical equipment in the EU and US: experience for Ukraine.

    Science.gov (United States)

    Pashkov, Vitalii; Kotvitska, Alla; Harkusha, Andrii

    2017-01-01

    The need for effective legal regulation of production and sale of medical products in Ukraine due to its social effect is obvious and requires a high level of clarity. The experience of more advanced countries in this area, given the way chosen by Ukraine to harmonize our laws with EU legislation, is certainly could be a useful source of information. The urgency of issues need further intensification of national legal reforms. Some key points on concept of legal regulation of abovementioned sphere is a base of this study. Legislation of Ukraine, European Union, United States of America, Guidelines, developed by European Commission & Food and Drug Administration's (FDA), recommendations represented by international voluntary group and scientific works. This article is based on dialectical, comparative, analytic, synthetic and comprehensive research methods. This study provide a possibility to state that main difference of regulatory systems in EU and US is that the legal framework of the EU is more flexible. This flexibility is grounded on main principle that only basic quality requirements for medical devices is defined by legislative acts however more detailed requirements are defined in standards, technical regulations, specifications, which are discretionary in nature. Contractors are free to choose any technical solution that provides compliance with the essential requirements, they can choose among different conformity assessment procedures and between accredited conformity assessment bodies to which they want to apply. The contractors themselves is interested to pass the conformity assessment procedure and have the right to put a conformity mark on their medical device because it will give them a real competitive advantage. In contrast, US State regulatory system provides strict control over business entities and law act establishes the quality requirements of medical products. The only body that can authorize the introduction of medical products and perform

  20. Disregarded use of herbal medical products and dietary supplements among surgical and medical patients as estimated by home inspection and interview

    DEFF Research Database (Denmark)

    Glintborg, Bente; Andersen, Stig Ejdrup; Spang-Hanssen, Eva

    2005-01-01

    PURPOSE: More and more patients use herbal medical products (HMP) and dietary supplements (DS). Due to the possibility of drug interactions and side effects, it is important that physicians are aware of the use. The aim of the present cross sectional survey was to analyse the consumption of HMP......% of the 211 HMP and DS used daily prior to admission were recorded in the hospital files. CONCLUSIONS: The use of HMP and DS was frequent among surgical and medical patients. The use was often not recorded in the hospital files and patients' knowledge of possible side effects and drug-interactions was minimal....... of registration. RESULTS: Totally, 83 surgical and 117 medical patients were included (n = 200), 139 patients (70%) were women. 53 patients (27%) stored no HMP or DS, whereas the home inventories of 147 patients (74%) comprised 343 products. 116 patients (58%) used HMP or DS daily and 25 patients (13%) used...

  1. Research productivity of junior academic staff at a tertiary medical college in south west, Nigeria.

    Science.gov (United States)

    Lesi, O A; Orenuga, O O; Roberts, A; Abudu, O O

    2009-01-01

    The research productivity of medical faculty has been well studied in developed countries, unlike in the developing countries. This study proposes to assess the level of research productivity over a 2 year period and identify the challenges to conducting research among junior academic staff of the College of Medicine, University of Lagos. An observational cross-sectional study in which the 120 junior academic staff from both basic sciences and clinical sciences were evaluated between January and September 2005. Data collection was by self-administered questionnaires distributed to the study population. There were 83 (69.1%) respondents comprising 38 males (45.6%) and 45 females (54.2%). The median age group was 31-40 years. Most respondents (57, 83%) spent less than 10 hours/week on research. On average they had completed 3-4 scholarly articles within the past 2 years. Nineteen (21.7%) of the subjects were considered to have optimal research productivity having completed over 5 scholarly research papers. The lecturers with optimal research productivity were significantly more likely to be male, and spent over 10 hours a week in hospital related clinical and laboratory related activities. (p = 0.02, and p = 0.03). Inadequate funding and laboratory facilities, and poor technological infrastructure were the most common causes of impediments to research reported by 78%, 69% and 55% of the lecturers respectively. Optimal research productivity was seen in about one quarter of the study population and was associated with male gender and prolonged duration of clinical/laboratory activities. Negligible research financing and poor laboratory support were major impediments to research productivity.

  2. Risiken und Nebenwirkungen der Integration medizinischer Software in klinische IT-Strukturen – Erlanger Memorandum [Software as a medical device – side effects when applying the new European regulation on medical devices for IT products

    OpenAIRE

    Kaiser, J.; Gassner, U.M.; Reng, M.; Prokosch, H.U.; Bürkle, T.

    2012-01-01

    [english] European medical device regulations have been altered to cover pure software applications as well. They now may be classified as a medical device if used for medical diagnostics and/or medical treatment. Slowly, these regulations are being implemented into national law of the EEC member states, for example into the German MPG (Medical Product Law).For some software applications such as Picture Archiving and Communication systems (PACS) a classification as medical device is – at leas...

  3. Production and Clinical Applications of Radiopharmaceuticals and Medical Radioisotopes in Iran.

    Science.gov (United States)

    Jalilian, Amir Reza; Beiki, Davood; Hassanzadeh-Rad, Arman; Eftekhari, Arash; Geramifar, Parham; Eftekhari, Mohammad

    2016-07-01

    During past 3 decades, nuclear medicine has flourished as vibrant and independent medical specialty in Iran. Since that time, more than 200 nuclear physicians have been trained and now practicing in nearly 158 centers throughout the country. In the same period, Tc-99m generators and variety of cold kits for conventional nuclear medicine were locally produced for the first time. Local production has continued to mature in robust manner while fulfilling international standards. To meet the ever-growing demand at the national level and with international achievements in mind, work for production of other Tc-99m-based peptides such as ubiquicidin, bombesin, octreotide, and more recently a kit formulation for Tc-99m TRODAT-1 for clinical use was introduced. Other than the Tehran Research Reactor, the oldest facility active in production of medical radioisotopes, there is one commercial and three hospital-based cyclotrons currently operational in the country. I-131 has been one of the oldest radioisotope produced in Iran and traditionally used for treatment of thyrotoxicosis and differentiated thyroid carcinoma. Since 2009, (131)I-meta-iodobenzylguanidine has been locally available for diagnostic applications. Gallium-67 citrate, thallium-201 thallous chloride, and Indium-111 in the form of DTPA and Oxine are among the early cyclotron-produced tracers available in Iran for about 2 decades. Rb-81/Kr-81m generator has been available for pulmonary ventilation studies since 1996. Experimental production of PET radiopharmaceuticals began in 1998. This work has culminated with development and optimization of the high-scale production line of (18)F-FDG shortly after installation of PET/CT scanner in 2012. In the field of therapy, other than the use of old timers such as I-131 and different forms of P-32, there has been quite a significant advancement in production and application of therapeutic radiopharmaceuticals in recent years. Application of (131)I

  4. Psychotropic medications from natural products: a review of promising research and recommendations.

    Science.gov (United States)

    Lake, J

    2000-05-01

    Most psychotropic agents employed in allopathic medicine have limited efficacy and significant side effects. Although usually beneficial, synthetic psychotropics are unavailable to approximately 80% of the world's population. Improved understanding of appropriate and safe uses of naturally occurring substances as psychotropic agents will greatly contribute to global mental healthcare. Empirical validation of non-allopathic treatments to ensure safety and efficacy is important because increasing numbers of patients in economically developed countries are using natural substances as medicinal agents. Patients and clinicians often lack accurate information, resulting in poor treatment outcomes or the possibility of drug-drug interactions when herbal medications are used with synthetic psychotropic medications. An important objective of this paper is to distinguish compelling scientific evidence supporting the use of natural products in psychiatry from political or institutional biases that have been misrepresented as scientific arguments. Following an overview of historical, legal, and regulatory issues, this paper presents findings of a systematic literature review on natural products used to treat neuropsychiatric disorders. Significant recent research is reviewed, including emerging treatments of seizure disorders, schizophrenia, dementia and age-related cognitive decline, depression, anxiety states, and substance abuse. Substantial evidence is advanced for safety and efficacy of many natural products used to treat neuropsychiatric symptoms or disorders. Preliminary findings suggest that several treatments based on natural substances are as effective and safe as synthetic pharmaceuticals in current use. Additional studies are indicated to confirm these findings, to elucidate mechanisms of action, and to elaborate standards for safe and appropriate treatment indications. In conclusion, strategic approaches aimed at facilitating improved networking, accelerating

  5. Acrylamide in food products - eating habits and consumer awareness among Medical School students.

    Science.gov (United States)

    Kowalska, Małgorzata; Żbikowska, Anna; Onacik-Gür, Sylwia; Kowalska, Dorota

    2017-12-23

    Acrylamide is formed in several foods during high-temperature processing. In view of reports written about the neurotoxic, genotoxic and carcinogenic effects of acrylamide, it was considered that the presence of this substance in food products might pose a risk for human health. Currently, according to EU Commission recommendations, the content of acrylamide in food should be monitored. The aim of this work was to analyze the food preferences of youth and students from medical schools in Radom, central-eastern Poland, as the most frequent precipitantsas in the field of food products that may be a significant source of acrylamide in the diet. Furthermore, an attempt was made to determine the level of knowledge of the population in the field of acrylamide. The research was conducted by questionnaire. The study was based on the answers of 227 respondents. The survey was carried out by direct contact with an interviewer from February - June 2012. Analysis of the study population shows that women consume more coffee than men. In addition, adults over 25 years old consumed the largest quantity of coffee; it can therefore be assumed that it is a significant source of acrylamide in their bodies. However, even young people under 17 declared that they consume coffee every day (20%). Due to the adverse effects of this compound it is important to reduce the level of acrylamide in food products. A few people in the population (7%) had heard of acrylamide previously, but none of them had any knowledge of its occurrence and formation. It is necessary to take strong action to change attitudes towards acrylamide and attempt to introduce ways to reduce this compound in the diet, for example, by appropriate selection of products in the daily diet and appropriate means of thermal preparation of products at home.

  6. Antimicrobial peptide production and plant-based expression systems for medical and agricultural biotechnology.

    Science.gov (United States)

    Holaskova, Edita; Galuszka, Petr; Frebort, Ivo; Oz, M Tufan

    2015-11-01

    Antimicrobial peptides (AMPs) are vital components of the innate immune system of nearly all living organisms. They generally act in the first line of defense against various pathogenic bacteria, parasites, enveloped viruses and fungi. These low molecular mass peptides are considered prospective therapeutic agents due to their broad-spectrum rapid activity, low cytotoxicity to mammalian cells and unique mode of action which hinders emergence of pathogen resistance. In addition to medical use, AMPs can also be employed for development of innovative approaches for plant protection in agriculture. Conferred disease resistance by AMPs might help us surmount losses in yield, quality and safety of agricultural products due to plant pathogens. Heterologous expression in plant-based systems, also called plant molecular farming, offers cost-effective large-scale production which is regarded as one of the most important factors for clinical or agricultural use of AMPs. This review presents various types of AMPs as well as plant-based platforms ranging from cell suspensions to whole plants employed for peptide production. Although AMP production in plants holds great promises for medicine and agriculture, specific technical limitations regarding product yield, function and stability still remain. Additionally, establishment of particular stable expression systems employing plants or plant tissues generally requires extended time scale for platform development compared to certain other heterologous systems. Therefore, fast and promising tools for evaluation of plant-based expression strategies and assessment of function and stability of the heterologously produced AMPs are critical for molecular farming and plant protection. Copyright © 2015 Elsevier Inc. All rights reserved.

  7. Occupational health and safety assessment of exposure to jet fuel combustion products in air medical transport.

    Science.gov (United States)

    MacDonald, Russell D; Thomas, Laura; Rusk, Frederick C; Marques, Shauna D; McGuire, Dan

    2010-01-01

    Transport medicine personnel are potentially exposed to jet fuel combustion products. Setting-specific data are required to determine whether this poses a risk. This study assessed exposure to jet fuel combustion products, compared various engine ignition scenarios, and determined methods to minimize exposure. The Beechcraft King Air B200 turboprop aircraft equipped with twin turbine engines, using a kerosene-based jet fuel (Jet A-1), was used to measure products of combustion during boarding, engine startup, and flight in three separate engine start scenarios ("shielded": internal engine start, door closed; "exposed": ground power unit start, door open; and "minimized": ground power unit right engine start, door open). Real-time continuous monitoring equipment was used for oxygen, carbon dioxide, carbon monoxide, nitrogen dioxide, hydrogen sulfide, sulfur dioxide, volatile organic compounds, and particulate matter. Integrated methods were used for aldehydes, polycyclic aromatic hydrocarbons, volatile organic compounds, and aliphatic hydrocarbons. Samples were taken in the paramedic breathing zone for approximately 60 minutes, starting just before the paramedics boarded the aircraft. Data were compared against regulated time-weighted exposure thresholds to determine the presence of potentially harmful products of combustion. Polycyclic aromatic hydrocarbons, aldehydes, volatile organic compounds, and aliphatic hydrocarbons were found at very low concentrations or beneath the limits of detection. There were significant differences in exposures to particulates, carbon monoxide, and total volatile organic compound between the "exposed" and "minimized" scenarios. Elevated concentrations of carbon monoxide and total volatile organic compounds were present during the ground power unit-assisted dual-engine start. There were no appreciable exposures during the "minimized" or "shielded" scenarios. Air medical personnel exposures to jet fuel combustion products were

  8. Model for Developing Educational Research Productivity: The Medical Education Research Group.

    Science.gov (United States)

    Perry, Marcia; Hopson, Laura; House, Joseph B; Fischer, Jonathan P; Dooley-Hash, Suzanne; Hauff, Samantha; Wolff, Margaret S; Sozener, Cemal; Nypaver, Michele; Moll, Joel; Losman, Eve D; Carney, Michele; Santen, Sally A

    2015-11-01

    Education research and scholarship are essential for promotion of faculty as well as dissemination of new educational practices. Educational faculty frequently spend the majority of their time on administrative and educational commitments and as a result educators often fall behind on scholarship and research. The objective of this educational advance is to promote scholarly productivity as a template for others to follow. We formed the Medical Education Research Group (MERG) of education leaders from our emergency medicine residency, fellowship, and clerkship programs, as well as residents with a focus on education. First, we incorporated scholarship into the required activities of our education missions by evaluating the impact of programmatic changes and then submitting the curricula or process as peer-reviewed work. Second, we worked as a team, sharing projects that led to improved motivation, accountability, and work completion. Third, our monthly meetings served as brainstorming sessions for new projects, research skill building, and tracking work completion. Lastly, we incorporated a work-study graduate student to assist with basic but time-consuming tasks of completing manuscripts. The MERG group has been highly productive, achieving the following scholarship over a three-year period: 102 abstract presentations, 46 journal article publications, 13 MedEd Portal publications, 35 national didactic presentations and five faculty promotions to the next academic level. An intentional focus on scholarship has led to a collaborative group of educators successfully improving their scholarship through team productivity, which ultimately leads to faculty promotions and dissemination of innovations in education.

  9. Radioactive Emissions from Fission-Based Medical Isotope Production and Their Effect on Global Nuclear Explosion Detection

    International Nuclear Information System (INIS)

    Bowyer, T.; Saey, P.

    2015-01-01

    The use of medical isotopes, such as Tc-99m, is widespread with over 30 million procedures being performed every year, but the fission-based production of isotopes used for medical procedures causes emissions into the environment. This paper will show that gaseous radioactive isotopes of xenon, such as Xe-133, are released in high quantities, because they have a high fission cross section and they are difficult to scrub from the processes used to produce the medical isotopes due to their largely unreactive nature. Unfortunately, the reasons that large amounts of radioactive xenon isotopes are emitted from isotope production are the same as those that make these isotopes the most useful isotopes for the detection of underground nuclear explosions. Relatively recently, the nuclear explosion monitoring community has established a provisional monitoring network for the Comprehensive Nuclear-Test-Ban Treaty (CTBT) that includes radioactive xenon monitoring as a major component. This community has discovered that emissions from medical isotope production present a more serious problem to nuclear explosion monitoring than thought when the network was first conceived. To address the growing problem, a group of scientists in both the monitoring and the isotope production communities have come together to attempt to find scientific and pragmatic ways to address the emissions problems, recognizing that medical isotope production should not be adversely affected, while monitoring for nuclear explosions should remain effective as isotope production grows, changes, and spreads globally. (author)

  10. Kolm Eesti Robinsoni: Daniel Defoe romaan eesti tõlkes / Three Estonian Robinsons: Daniel Defoe’s Novel in Estonian Translation

    Directory of Open Access Journals (Sweden)

    Ene-Reet Soovik

    2012-06-01

    Full Text Available The article discusses three Estonian translations of Daniel Defoe’s Robinson Crusoe into Estonian with the focus on the completeness of the translated texts and the characterisation given to these in paratextual information. While there are several translations and versions of the tex t available in E stonian that have either used a mediating language or do not proceed directly from Defoe’s novel, three editions explicitly list Defoe’s English-language Robinson Crusoe as their source text. These are Rudolf Sirge’s translation from 1950 and two editions translated by Valter Rummel that appeared in 1984 (reprinted in 2001 and 2007, respectively. The article sets out to discover the main differences between the three editions and the possible reasons that may have triggered their publication in Estonia at those particular times. In order to approach the issues, a general framework derived from descriptive translation studies is employed with an emphasis on Gideon Toury’s chrestomatic treatment of translation norms. Thus an attempt is made to detect the preliminary translational norms regarding translation policy, particularly the choice of texts to be translated, as well as the matricial norms that concern the fullness of the translated text and are part of operational norms manifested in the translator’s decisions which, in two of the cases at hand, may also have been decisions made by the editor or the censor. Rudolf Sirge’s translation appeared at a time when Estonia had fairly recently been incorporated into the Soviet Union and there was a lack of children’s literature ideologically appreciated by the regime. This may account for the packaging of the book as a work with a strong didactic bent, while its primary audience was taken to be children and young adults for whom the protagonist served as an example of a hard-working and tenacious hero to be emulated by young Soviets. The target text has been considerably shortened as

  11. Work-based Assessment and Co-production in Postgraduate Medical Training

    Directory of Open Access Journals (Sweden)

    Holmboe, Eric S.

    2017-11-01

    Full Text Available Assessment has always been an essential component of postgraduate medical education and for many years focused predominantly on various types of examinations. While examinations of medical knowledge and more recently of clinical skills with standardized patients can assess learner capability in controlled settings and provide a level of assurance for the public, persistent and growing concerns regarding quality of care and patient safety worldwide has raised the importance and need for better work-based assessments. Work-based assessments, when done effectively, can more authentically capture the abilities of learners to actually provide safe, effective, patient-centered care. Furthermore, we have entered the era of interprofessional care where effective teamwork among multiple health care professionals is now paramount. Work-based assessment methods are now essential in an interprofessional healthcare world.To better prepare learners for these newer competencies and the ever-growing complexity of healthcare, many post-graduate medical education systems across the globe have turned to outcomes-based models of education, codified through competency frameworks. This commentary provides a brief overview on key methods of work-based assessment such as direct observation, multisource feedback, patient experience surveys and performance measures that are needed in a competency-based world that places a premium on educational and clinical outcomes. However, the full potential of work-based assessments will only be realized if post-graduate learners play an active role in their own assessment program. This will require a substantial culture change, and culture change only occurs through actions and changed behaviors. Co-production offers a practical and philosophical approach to engaging postgraduate learners to be active, intrinsically motivated agents for their own professional development, help to change learning culture and contribute to improving

  12. Estonian exceptionalism

    Index Scriptorium Estoniae

    2011-01-01

    Ulatuslikud kärped ja liitumine eurotsooniga toovad Eestist häid majandusuudiseid: töötus langeb, majandus kasvab, eksport tõuseb, eelarve on plussis, reitinguagentuur Fitch krediidireiting tõusis tasemele A+

  13. Dosimetric systems of high dose, dose rate and dose uniformity in food and medical products

    International Nuclear Information System (INIS)

    Vargas, J.; Vivanco, M.; Castro, E.

    2014-08-01

    In the Instituto Peruano de Energia Nuclear (IPEN) we use the chemical dosimetry Astm-E-1026 Fricke as a standard dosimetric system of reference and different routine dosimetric systems of high doses, according to the applied doses to obtain the desired effects in the treated products and the doses range determined for each type of dosimeter. Fricke dosimetry is a chemical dosimeter in aqueous solution indicating the absorbed dose by means an increase in absorbance at a specific wavelength. A calibrated spectrophotometer with controlled temperature is used to measure absorbance. The adsorbed dose range should cover from 20 to 400 Gy, the Fricke solution is extremely sensitive to organic impurities, to traces of metal ions, in preparing chemical products of reactive grade must be used and the water purity is very important. Using the referential standard dosimetric system Fricke, was determined to March 5, 2013, using the referential standard dosimetric system Astm-1026 Fricke, were irradiated in triplicate Fricke dosimeters, to 5 irradiation times (20; 30; 40; 50 and 60 seconds) and by linear regression, the dose rate of 5.400648 kGy /h was determined in the central point of the irradiation chamber (irradiator Gamma cell 220 Excel), applying the decay formula, was compared with the obtained results by manufacturers by means the same dosimetric system in the year of its manufacture, being this to the date 5.44691 kGy /h, with an error rate of 0.85. After considering that the dosimetric solution responds to the results, we proceeded to the irradiation of a sample of 200 g of cereal instant food, 2 dosimeters were placed at the lateral ends of the central position to maximum dose and 2 dosimeters in upper and lower ends as minimum dose, they were applied same irradiation times; for statistical analysis, the maximum dose rate was 6.1006 kGy /h and the minimum dose rate of 5.2185 kGy /h; with a dose uniformity of 1.16. In medical material of micro pulverized bone for

  14. NIAID/NIH radiation/nuclear medical countermeasures product research and development program.

    Science.gov (United States)

    Hafer, Nathaniel; Cassatt, David; Dicarlo, Andrea; Ramakrishnan, Narayani; Kaminski, Joseph; Norman, Mai-Kim; Maidment, Bert; Hatchett, Richard

    2010-06-01

    One of the greatest national security threats to the United States is the detonation of an improvised nuclear device or a radiological dispersal device in a heavily populated area. The U.S. Government has addressed these threats with a two-pronged strategy of preventing organizations from obtaining weapons of mass destruction and preparing in case an event occurs. The National Institute of Allergy and Infectious Diseases (NIAID) contributes to these preparedness efforts by supporting basic research and development for chemical, biological, radiological, and nuclear countermeasures for civilian use. The Radiation Countermeasures Program at NIAID has established a broad research agenda focused on the development of new medical products to mitigate and treat acute and long-term radiation injury, promote the clearance of internalized radionuclides, and facilitate accurate individual dose and exposure assessment. This paper reviews the recent work and collaborations supported by the Radiation Countermeasures Program.

  15. Feasibility study on medical isotope production using a compact neutron generator.

    Science.gov (United States)

    Leung, Ka-Ngo; Leung, James K; Melville, Graeme

    2018-03-07

    Compact neutron generators can provide high flux of neutrons with energies ranging from thermal (0.025 eV) to 14 MeV. Recent measurements demonstrated high neutron yields from the D- 7 Li fusion reaction at an interaction energy of 500 keV. Using the D- 7 Li reaction and applying new advancements in high flux neutron generator technology along with the commercial availability of high voltage DC power supplies enables the production of useful quantities of radioisotopes for medical applications. Using the known neutron reaction cross-sections, it has been estimated that hundreds-to-thousands MBq (or tens-to-hundreds mCi) of 99 Mo, 225 Ac, 64 Cu and 67 Cu can be obtained from a compact high flux neutron generator. Copyright © 2018 Elsevier Ltd. All rights reserved.

  16. Publication productivity and citation analysis of the Medical Journal of Malaysia: 2004 - 2008.

    Science.gov (United States)

    Sanni, S A; Zainab, A N

    2012-02-01

    We analysed 580 articles (original articles only) published in Medical Journal of Malaysia between 2004 and 2008, the resources referenced by the articles and the citations and impact received. Our aim was to examine article and author productivity, the age of references used and impact of the journal. Publication data was obtained from MyAIS database and Google Scholar provided the citation data. From the 580 articles analyzed, contributors mainly come from the hospitals, universities and clinics. Contributions from foreign authors are low. The useful lives of references cited were between 3 to 11 years. ISI derived Impact factor for MJM ranged between 0.378 to 0.616. Journal self-citation is low. Out of the 580 sampled articles, 76.8% have been cited at least once over the 5 years and the ratio of total publications to citations is 1: 2.6.

  17. Knowledge Production in Two Types of Medical PhD Routes—What’s to Gain?

    Directory of Open Access Journals (Sweden)

    Andrada Elena Urda-Cîmpean

    2016-06-01

    Full Text Available Purpose: To assess the assumption that differences exist between the traditional and publication-based PhD routes in terms of the thesis’ length and the scientific publications originating from it. Method: A retrospective comparative study on medical PhD theses offered by an online repository was performed. All free full-text medical PhD theses defended at United Kingdom institutions between 2003 and 2015 were analyzed and assigned to the traditional (TT or publication based thesis (PBT group. Several characteristics of theses and thesis-related articles were collected and analyzed. The thesis-related articles were investigated regarding quantity and visibility (citations, impact factor, and journal rank. Results: The theses length proved similar in PBT and TT group. PBT group included significantly more studies than TT group (mean 4.44 vs. 2.67 also reflected in significantly more thesis-related articles. The percentage of articles listed in Web of Science and published in a journal with impact factor proved significantly lower in TT compared with PBT group. On the contrary, article citations were significantly higher for TT. Both groups published similarly in high-ranked journals (Q1 or Q2. Conclusion: The research productivity originating from the PBT group was, as expected, significantly larger but not significantly more visible than those from TT group.

  18. BORDERLINE AND CLASSIFICATION IN THE COMMUNITY REGULATORY FRAMEWORK FOR MEDICAL DEVICES – BRIEF REVIEW ON SOME DENTISTRY PRODUCTS.

    Directory of Open Access Journals (Sweden)

    Maya Lyapina

    2015-02-01

    Full Text Available Defining a given product as a medical device and interpretation of the application of the classification rules fall within the competence of the competent authorities of the Member States where the product is on the market. Different interpretations of Community legislation occur, and, can put public health at risk and distort the internal market. Borderline cases are considered to be those cases where it is not clear from the outset whether a given product is a medical device, an in vitro diagnostic medical device, an active implantable medical device or not. Classification cases can be described as those cases where there exists a difficulty in the uniform application of the classification rules as laid down in the Medical Devices Directive (MDD, or where for a given device, depending on interpretation of the rules, different classifications can occur. The aim of the present work is to make a brief review on discussion on classification in the community regulatory framework for medical devices of some dentistry products.

  19. With or without articles? A comparison of article-like determiners in Estonian and Finnish

    Directory of Open Access Journals (Sweden)

    Helen Hint

    2017-10-01

    Full Text Available In this paper, we compare the use and functions of definite and indefinite article-like determiners in Estonian and Finnish. Our main aim is to explore whether the factors that explain the choice of particular determiner forms are similar in Estonian and Finnish. We use a picture-sequence based elicitation experiment to collect spoken narratives from adult native speakers of Estonian and Finnish, and apply non-parametric tree and forest models to analyze the data. Our findings indicate that number of mention and animacy are important predictor variables in both languages, but their exact effect is divergent. We also find that in Finnish, case of the determiner NP proves to be an important factor, while in Estonian, syntactic role of the NP explains some aspects of determiner form choice. Nevertheless, the overall usage frequency of determiners is modest in the Estonian and Finnish data, and the process of grammaticalizing articles is only in initial stages in both languages. *** Artikliga, artiklita? Eesti ja soome keele artiklilaadsete määratlejate võrdlus Siinses uurimuses analüüsime võrdlevalt artiklilaadseid definiitseid ja indefiniitseid määratlejaid eesti ja soome keeles. Eelkõige kõrvutame eesti keele definiitset määratlejat see ja soome keele definiitseid määratlejaid se ja tämä ning eesti ja soome indefiniitset määratlejat üks/yks(i. Samuti vaatleme eesti keele possessiivpronoomeni oma ning soome 3sg possessiivsufiksi (-nsa/-nsä, -Vn referentsiaalseid omadusi. Uurimuse põhieesmärgiks on selgitada, millised on peamised määratlejate kasutust mõjutavad keelelised faktorid eesti ja soome keeles ning kas need faktorid on keeliti sarnased või erinevad. Ühtlasi otsime vastust küsimusele, kas eesti ja soome keeles on põhjust rääkida määratlejate grammatisatsioonist artikliteks. Uuritav keelematerjal pärineb pildiseeria põhjal kogutud suulistest narratiividest. Uurimuses osales 20 eesti ja 20 soome keele

  20. Estimates of radioxenon released from Southern Hemisphere medical isotope production facilities using measured air concentrations and atmospheric transport modeling.

    Science.gov (United States)

    Eslinger, Paul W; Friese, Judah I; Lowrey, Justin D; McIntyre, Justin I; Miley, Harry S; Schrom, Brian T

    2014-09-01

    The International Monitoring System (IMS) of the Comprehensive-Nuclear-Test-Ban-Treaty monitors the atmosphere for radioactive xenon leaking from underground nuclear explosions. Emissions from medical isotope production represent a challenging background signal when determining whether measured radioxenon in the atmosphere is associated with a nuclear explosion prohibited by the treaty. The Australian Nuclear Science and Technology Organisation (ANSTO) operates a reactor and medical isotope production facility in Lucas Heights, Australia. This study uses two years of release data from the ANSTO medical isotope production facility and (133)Xe data from three IMS sampling locations to estimate the annual releases of (133)Xe from medical isotope production facilities in Argentina, South Africa, and Indonesia. Atmospheric dilution factors derived from a global atmospheric transport model were used in an optimization scheme to estimate annual release values by facility. The annual releases of about 6.8 × 10(14) Bq from the ANSTO medical isotope production facility are in good agreement with the sampled concentrations at these three IMS sampling locations. Annual release estimates for the facility in South Africa vary from 2.2 × 10(16) to 2.4 × 10(16) Bq, estimates for the facility in Indonesia vary from 9.2 × 10(13) to 3.7 × 10(14) Bq and estimates for the facility in Argentina range from 4.5 × 10(12) to 9.5 × 10(12) Bq. Copyright © 2014 Elsevier Ltd. All rights reserved.

  1. How nuclear data collected for medical radionuclides production could constrain nuclear codes

    Science.gov (United States)

    Guertin, Arnaud; Duchemin, Charlotte; Fardin, Arnaud; Guigot, Corentin; Nigron, Etienne; Remy, Charlotte; Haddad, Férid; Michel, Nathalie; Métivier, Vincent

    2017-09-01

    The aim of this article is to give the status of nuclear data collected in the framework of the production of innovative radionuclides for therapy and diagnosis applications in collaboration with the GIP ARRONAX, which possesses a multi-particle high energy cyclotron, and to show constrains that can be put on nuclear codes. In order to assess the cross section of a given production route, experiments have been carried out using the stacked-foil technique and gamma-spectroscopy for a set of radionuclides of medical interest: photon (Tc-99m) and positon (Sc-44g) emitters for diagnosis, electron (Re-186g, Tb-155, Sn-117m) and alpha particle (Th-226, Ra-233, Bi-213) emitters for therapeutic applications. A systematic comparison has been performed between the results from the TALYS code (version 1.6) and the large set of data collected using different projectiles (proton, deuteron and alpha particle) from few MeV up to 70 MeV and covering a wide range of target masses. A better overall agreement with our experimental data has been obtained with a combination of models already included in the TALYS code differing from the default one.

  2. Possibility of using gamma radiation from HTR reactors for the processing of food and medical products

    International Nuclear Information System (INIS)

    Pahladsingh, R.R.

    2004-01-01

    During the fission process in most of the presently operating nuclear reactors nuclear energy is converted into thermal energy and transferred to common steam cycles for power generation. As part of the fission process also α, β and neutrons particles are released from the nucleus; the release of gamma-rays is also a part of the fission process. In present nuclear reactors α, β, neutrons particles and particularly gamma-rays are not gainfully used as a result of the reactor design and of the containment. These plants are built as required by regulations and international standards for safety. The inherently safe HTR reactor, by its physics and design, does not need a special reinforced containment and it is worth looking into the possibilities of this design feature to use the by-products, such as Gamma-rays, from nuclear fission. In the HTR Pebble Bed Reactors the α, and β particles will remain in the kernels of the pebbles. This means that only the neutron particles and gamma-rays will be available outside the reactor pressure vessel. In this report a proposal is presented to use the gamma-rays of the HTR reactor for irradiation of food and agricultural produce. For neutron shielding a reflector is placed inside the reactor while outside the reactor neutron- and thermal-shielding will be accomplished with water. The high energy gamma-rays will pass through the water-shield and could be harnessed for radiation processing of food and medical products. (author)

  3. Postcolonial heterotopias in Marek Piestrak's Estonian co-productions : a paracinematic reading / Eva Näripea

    Index Scriptorium Estoniae

    Näripea, Eva, 1980-

    2014-01-01

    M.Piestraki populaarsete ja "parafilmidena" käsitletavate "Navigaator Prix"(1978) ja "Madude oru needus"(1988) analüüs. Piestraki filmide ruumimaailmu uurides toetutakse Foucault' heterotoopiakontseptsioonile ja mõningatele postkolonialistku teooria mõttekäikudele

  4. Competitiveness of Estonian milk production / Katri Lahesoo, Ülle Roosmaa, Johannes Holzner

    Index Scriptorium Estoniae

    Lahesoo, Katri, 1973-

    2003-01-01

    Eesti piimatootmise konkurentsivõime analüüs võrreldes mõningate Kesk- ja Ida-Euroopa ning Euroopa Liidu riikidega, kasutatud on selleks IFCN Dairy 2001. aasta andmebaasi ja tüüptalude metodoloogiat. Diagrammid

  5. Production functions of Estonian banking 1995-2002 / August Aarma, Jaan Vainu

    Index Scriptorium Estoniae

    Aarma, August, 1948-

    2003-01-01

    Analüüsi tulemusena järeldavad autorid, et erinevatel kliendigruppidel on panga suhtes erinevad ootused, nad vajavad erinevat informatsiooni ja erinevad analüüsimeetodid võimaldavad saada erinevat liiki informatsiooni. Tabelid

  6. Dedication increases productivity: an analysis of the implementation of a dedicated medical team in the emergency department.

    Science.gov (United States)

    Ramos, Pedro; Paiva, José Artur

    2017-12-01

    In several European countries, emergency departments (EDs) now employ a dedicated team of full-time emergency medicine (EM) physicians, with a distinct leadership and bed-side emergency training, in all similar to other hospital departments. In Portugal, however, there are still two very different models for staffing EDs: a classic model, where EDs are mostly staffed with young inexperienced physicians from different medical departments who take turns in the ED in 12-h shifts and a dedicated model, recently implemented in some hospitals, where the ED is staffed by a team of doctors with specific medical competencies in emergency medicine that work full-time in the ED. Our study assesses the effect of an intervention in a large academic hospital ED in Portugal in 2002, and it is the first to test the hypothesis that implementing a dedicated team of doctors with EM expertise increases the productivity and reduces costs in the ED, maintaining the quality of care provided to patients. A pre-post design was used for comparing the change on the organisational model of delivering care in our medical ED. All emergency medical admissions were tracked in 2002 (classic model with 12-h shift in the ED) and 2005/2006 (dedicated team with full-time EM physicians), and productivity, costs with medical human resources and quality of care measures were compared. We found that medical productivity (number of patients treated per hour of medical work) increased dramatically after the creation of the dedicated team (X 2 KW = 31.135; N = 36; p work reduced both in regular hours and overtime. Moreover, hospitalisation rates decreased and the length of stay in the ED increased significantly after the creation of the dedicated team. Implementing a dedicated team of doctors increased the medical productivity and reduced costs in our ED. Our findings have straightforward implication for Portuguese policymakers aiming at reducing hospital costs while coping with increased ED demand.

  7. Trends, Productivity Losses, and Associated Medical Conditions Among Toxoplasmosis Deaths in the United States, 2000–2010

    Science.gov (United States)

    Cummings, Patricia L.; Kuo, Tony; Javanbakht, Marjan; Sorvillo, Frank

    2014-01-01

    Few studies have quantified toxoplasmosis mortality, associated medical conditions, and productivity losses in the United States. We examined national multiple cause of death data and estimated productivity losses caused by toxoplasmosis during 2000–2010. A matched case–control analysis examined associations between comorbid medical conditions and toxoplasmosis deaths. In total, 789 toxoplasmosis deaths were identified during the 11-year study period. Blacks and Hispanics had the highest toxoplasmosis mortality compared with whites. Several medical conditions were associated with toxoplasmosis deaths, including human immunodeficiency virus (HIV), lymphoma, leukemia, and connective tissue disorders. The number of toxoplasmosis deaths with an HIV codiagnosis declined from 2000 to 2010; the numbers without such a codiagnosis remained static. Cumulative disease-related productivity losses for the 11-year period were nearly $815 million. Although toxoplasmosis mortality has declined in the last decade, the infection remains costly and is an important cause of preventable death among non-HIV subgroups. PMID:25200264

  8. Investigation of science production in Iran’s type I universities of medical sciences, a 6-year assessment

    Directory of Open Access Journals (Sweden)

    M Yadollahi

    2014-07-01

    Full Text Available Introduction: Science production is one of the main dimensions of sustainable development in any country. Thus, universities as the major centers for science production play a key role in development. The present study aimed to assess the trend of science production in Iran’s type I universities of medical sciences from 2007 to 2012. Method: In this study, the universities’ scores of empowering, governance and leadership, science production, student researches, and number of published articles were computed based on the evaluations of universities of medical sciences by the Ministry of Health, Treatment, and Medical Education from 2007 to 2012. Then, the data were analyzed using descriptive statistics and the figures were drawn by Excel software. Results: This study assessed science production in Iran’s type I universities of medical sciences and analyzed each university’s proportion in publication of articles. According to the results, most of the published articles were affiliated to Tehran University of Medical Sciences. However, considering the role of number of faculty members, different results were obtained. With respect to the evaluation raw scores, Isfahan University of Medical Sciences showed a considerable reduction of scores in 2012, while other universities had a constant or ascending trend. Besides, indexed articles followed an ascending trend in all the universities and most of the articles had been published in index 1. Conclusion: Similar to other studies, the findings of this study revealed an increase in science productions in Iran through the recent years. Yet, the highest scores of the studied indexes, except for student researches, were related to Tehran University of Medical Sciences. This great difference between this university and other universities might be due to accumulation of specific potentials and forces in this region. Overall, science productions followed an ascending trend in all type I universities of

  9. Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV.

    Science.gov (United States)

    Duchemin, C; Guertin, A; Haddad, F; Michel, N; Métivier, V

    2015-02-07

    The irradiation of a thorium target by light charged particles (protons and deuterons) leads to the production of several isotopes of medical interest. Direct nuclear reaction allows the production of Protactinium-230 which decays to Uranium-230 the mother nucleus of Thorium-226, a promising isotope for alpha radionuclide therapy. The fission of Thorium-232 produces fragments of interest like Molybdenum-99, Iodine-131 and Cadmium-115g. We focus our study on the production of these isotopes, performing new cross section measurements and calculating production yields. Our new sets of data are compared with the literature and the last version of the TALYS code.

  10. Production of medical isotopes from a thorium target irradiated by light charged particles up to 70 MeV

    Science.gov (United States)

    Duchemin, C.; Guertin, A.; Haddad, F.; Michel, N.; Métivier, V.

    2015-02-01

    The irradiation of a thorium target by light charged particles (protons and deuterons) leads to the production of several isotopes of medical interest. Direct nuclear reaction allows the production of Protactinium-230 which decays to Uranium-230 the mother nucleus of Thorium-226, a promising isotope for alpha radionuclide therapy. The fission of Thorium-232 produces fragments of interest like Molybdenum-99, Iodine-131 and Cadmium-115g. We focus our study on the production of these isotopes, performing new cross section measurements and calculating production yields. Our new sets of data are compared with the literature and the last version of the TALYS code.

  11. 75 FR 391 - Medical Device Quality System Regulation Educational Forum on Risk Management Through the Product...

    Science.gov (United States)

    2010-01-05

    ... Cycle; Public Workshop AGENCY: Food and Drug Administration, HHS. ACTION: Notice of public workshop...), is announcing a public workshop entitled ``Medical Device Quality System Regulation Educational Forum... information about FDA's Medical Device Quality Systems Regulation (QSR) to the regulated industry...

  12. 75 FR 74063 - Supplemental Funding Under the Food and Drug Administration's Convener of Active Medical Product...

    Science.gov (United States)

    2010-11-30

    ... dissemination of Patient Medication Information (PMI). With this FOA, FDA proposes to further expand the scope... paragraphs. Patient Medication Information (PMI) To be able to use prescription medications safely, consumers... Guides. Such changes to the delivery of PMI may require changes to the Federal Food, Drug, and Cosmetics...

  13. Frost related dieback in Estonian energy plantations of willows in relation to fertilisation and pathogenic bacteria

    Energy Technology Data Exchange (ETDEWEB)

    Cambours, M.A.; Nejad, P. [Department of Forest Mycology and Pathology, Swedish University of Agricultural Sciences, Box 7026, 750 07 Uppsala (Sweden); Heinsoo, K. [Institute of Zoology and Botany, Estonian Agricultural University, Riia 181, 51014 Tartu (Estonia); Granhall, U. [Department of Microbiology, Swedish University of Agricultural Sciences, Box 7025, 750 07 Uppsala (Sweden)

    2006-03-15

    Two 9-year old Estonian Salix plantations suffering from dieback were studied: one situated on poor mineral soil and divided into fertilised and unfertilised plots (Saare plantation) and another growing on a well-decomposed and nitrogen-rich organic soil, without fertiliser application (Kambja plantation). Bacteria from internal tissues of visually damaged shoots from seven clones were isolated in spring and autumn. The strains were subsequently biochemically characterised and tested for ice nucleation activity and pathogenicity on Salix. Some strains were also analysed with 16S rRNA. High numbers of culturable bacteria were found, belonging mainly to Erwinia, Sphingomonas, Pseudomonas and Xanthomonas spp. Fertilised plots were significantly more colonised by bacteria than unfertilised plots and also more extensively damaged, showing a lower density of living plants after 7 years of culture. More ice nucleation active (INA) strains were found in Saare fertilised plots and at Kambja than in Saare unfertilised plots. Likewise, most pathogenic strains were isolated from Saare fertilised plots and from Kambja. For some of the willow clones studied, dieback appeared to be related to both clonal frost sensitivity and abundance of INA and pathogenic bacteria. The plantations probably suffered from the presence of high amounts of pathogens and from frost related injuries aggravated by INA bacteria. Most probably the fertilisation at Saare and the nitrogen-rich soil at Kambja created a favourable environment for bacterial development and led to high dieback levels after the first harvest. (author)

  14. Vitality of the Estonian forests (results of the inventory and research)

    International Nuclear Information System (INIS)

    Karoles, K.

    1991-01-01

    Factors affecting Estonian forests are: The environmental, specially atmospheric pollution, - the foundation of new forests as monoculture on unsuitable locations, - mechanical damages by unsuitable forest machinery, - unfavourable water conditions, - Heterobasidion or Armillaria rot roots. Local damages in consequence of air pollutants are distributed in environments of Tallinn, Kivioli, Kohtla-Jaerve and the thermal power stations (Narva), where the SO 2 -content in the air is on the average higher than 50 (80) μg/m 3 . Pine forests on dry sand soils (600 ha damaged in 1989) and the older spruce forests show the new type of forest decline. High Al-ion concentration, disturbances of the Ca-Mg-metabolism, an extreme nutrient deficit, (specially N-deficit) and periodical water deficit as well as pathogenic fungi are damaging the trees. Spruces show nonspecific defoliation, needle necrosis, needlefall, occurence of fungal diseases. More damaged are the spruce forests in regions with basic precipitations and high sulphur-deposition. (orig./UWA) [de

  15. The very first words of Estonian children: A comparison of two parental report types

    Directory of Open Access Journals (Sweden)

    Astra Schults

    2015-06-01

    Full Text Available Background: Parental recognition has been shown to produce more accurate information about child’s vocabulary compared to remembering. The differences in reporting vocabulary are of interest. Our aims were to determine the extent of vocabulary overlap in the two report types, to identify the word report frequency and the proportions of word categories according to the report type. Methods: The subjects were 219 children (125 boys and 94 girls at the age of 0;8 to 1;4 (M = 10.41, SD = 1.96 who had one to three words reported in the ECDI Infant Form. In this study parents reported children’s current vocabulary in two ways: Estonian version of MacArthur-Bates Communicative Development Inventory: Language and Gestures (henceforth ECDI Infant Form and free recall. Results: On 40% of occasions a word was reported in both ways. Three most frequent words in both report types were aitäh ‘thanks’, nämm-nämm ‘yum-yum’, and emme ‘mommy’. Words belonging to the categories of sound effects and animal sounds as well as social terms had higher average frequency of reports than common nouns regardless of report type. Conclusions: These results may reflect differences in what parents consider to be a word and raise a question of social desirability in parental reports.

  16. Fungal associates of Pyrola rotundifolia, a mixotrophic Ericaceae, from two Estonian boreal forests.

    Science.gov (United States)

    Vincenot, Lucie; Tedersoo, Leho; Richard, Franck; Horcine, Houria; Kõljalg, Urmas; Selosse, Marc-André

    2008-12-01

    Pyrola rotundifolia (Ericaceae, Pyroleae tribe) is an understorey subshrub that was recently demonstrated to receive considerable amount of carbon from its fungal mycorrhizal associates. So far, little is known of the identity of these fungi and the mycorrhizal anatomy in the Pyroleae. Using 140 mycorrhizal root fragments collected from two Estonian boreal forests already studied in the context of mixotrophic Ericaceae in sequence analysis of the ribosomal DNA internal transcribed spacer region, we recovered 71 sequences that corresponded to 45 putative species in 19 fungal genera. The identified fungi were mainly ectomycorrhizal basidiomycetes, including Tomentella, Cortinarius, Russula, Hebeloma, as well as some ectomycorrhizal and/or endophytic ascomycetes. The P. rotundifolia fungal communities of the two forests did not differ significantly in terms of species richness, diversity and nutritional mode. The relatively high diversity retrieved suggests that P. rotundifolia does not have a strict preference for any fungal taxa. Anatomical analyses showed typical arbutoid mycorrhizae, with variable mantle structures, uniseriate Hartig nets and intracellular hyphal coils in the large epidermal cells. Whenever compared, fungal ultrastructure was congruent with the molecular identification. Similarly to other mixotrophic and autotrophic pyroloids in the same forests, P. rotundifolia shares its mycorrhizal fungal associates with surrounding trees that are likely a carbon source for pyroloids.

  17. Trade Union Responses to Transnational Labour Mobility in the Finnish-Estonian Context

    Directory of Open Access Journals (Sweden)

    Rolle Alho

    2013-09-01

    Full Text Available This article examines trade union strategies in relation to labor migration in Estonia and Finland, drawing on face-to-face interviews with trade unionists and official union statements. The study considers the national trade union strategies located in two separate but interconnected localities that represent different approaches to market economy. Previous research suggests that the national industrial relations system is a key factor in explaining unions’ labor migration strategies. Unions operating in liberal market economies are claimed to be more open toward immigration and more inclusive toward immigrants than unions in coordinated markets. This study analyzes the extent to which this theory holds in the context of Estonia and Finland—Finland representing a coordinated market economy and Estonia a liberal market economy. Furthermore, the analysis examines how the emergence of a translocal labor market, resulting from the geographical vicinity and linguistic affinity between Finland and Estonia as well as from free mobility within the EU, is reflected in trade union approaches to labor migration. The study finds that Finnish trade union strategies influence labor mobility, whereas Estonian trade unions remain bystanders in the issue.

  18. Photosynthetic biomanufacturing in green algae; production of recombinant proteins for industrial, nutritional, and medical uses.

    Science.gov (United States)

    Rasala, Beth A; Mayfield, Stephen P

    2015-03-01

    Recombinant proteins are widely used for industrial, nutritional, and medical applications. Green microalgae have attracted considerable attention recently as a biomanufacturing platform for the production of recombinant proteins for a number of reasons. These photosynthetic eukaryotic microorganisms are safe, scalable, easy to genetically modify through transformation, mutagenesis, or breeding, and inexpensive to grow. Many microalgae species are genetically transformable, but the green alga Chlamydomonas reinhardtii is the most widely used host for recombinant protein expression. An extensive suite of molecular genetic tools has been developed for C. reinhardtii over the last 25 years, including a fully sequenced genome, well-established methods for transformation, mutagenesis and breeding, and transformation vectors for high levels of recombinant protein accumulation and secretion. Here, we review recent successes in the development of C. reinhardtii as a biomanufacturing host for recombinant proteins, including antibodies and immunotoxins, hormones, industrial enzymes, an orally-active colostral protein for gastrointestinal health, and subunit vaccines. In addition, we review the biomanufacturing potential of other green algae from the genera Dunaliella and Chlorella.

  19. New Production Routes for Medical Isotopes 64Cu and 67Cu Using Accelerator Neutrons

    Science.gov (United States)

    Kin, Tadahiro; Nagai, Yasuki; Iwamoto, Nobuyuki; Minato, Futoshi; Iwamoto, Osamu; Hatsukawa, Yuichi; Segawa, Mariko; Harada, Hideo; Konno, Chikara; Ochiai, Kentaro; Takakura, Kosuke

    2013-03-01

    We have measured the activation cross sections producing 64Cu and 67Cu, promising medical radioisotopes for molecular imaging and radioimmunotherapy, by bombarding a natural zinc sample with 14 MeV neutrons. We estimated the production yields of 64Cu and 67Cu by fast neutrons from \\text{natC(d,n) with 40 MeV 5 mA deuterons. We used the present result together with the evaluated cross section of Zn isotopes. The calculated 64Cu yield is 1.8 TBq (175 g 64Zn) for 12 h of irradiation; the yields of 67Cu by 67Zn(n,p)67Cu and 68Zn(n,x)67Cu were 249 GBq (184 g 67Zn) and 287 GBq (186 g 68Zn) at the end of 2 days of irradiation, respectively. From the results, we proposed a new route to produce 67Cu with very little radionuclide impurity via the 68Zn(n,x)67Cu reaction, and showed the 64Zn(n,p)64Cu reaction to be a promising route to produce 64Cu. Both 67Cu and 64Cu are noted to be produced using fast neutrons.

  20. The production of radioisotopes for medical applications by the adiabatic resonance crossing (ARC) technique

    CERN Document Server

    Froment, P; Delbar, T; Ryckewaert, G; Tilquin, I; Vervier, J

    2002-01-01

    The Transmutation by Adiabatic Resonance Crossing (TARC) technique has been proposed by Rubbia (Resonance enhanced neutron captures for element activation and waste transmutation, CERN-LHC/97-0040EET, 1997; TARC collaboration, Neutron-driven nuclear transmutation by adiabatic resonance crossing, CERN-SL-99-036EET, 1999; Abanades et al., Nucl. Instr. and Meth. A 487 (2002) 577) for element activation and waste transmutation. We investigate the possibility to use this technique for the industrial production of **9**9Mo and **1**2**5Xe by resonance neutron capture in **9**8Mo and **1**2**4Xe, respectively. Their daughters, i.e. **9**9**mTc and **1**2**5I, are widely used in medical applications. The high neutron flux needed is produced by bombarding a thick Be target with 65 or 75 MeV proton beam (few microamperes). This target is placed at the centre of a large cubic lead assembly (1.6 m side, purity: 99.999%). The neutrons are progressively slowed down by elastic scattering on lead, and their energies "scan" t...

  1. Nuclear Reactors and Production of Medical Radioisotopes: Case of the Tunisian Subcritical Assembly

    Energy Technology Data Exchange (ETDEWEB)

    Jelassi, Haikel [CNSTN, Tunis (Turkey)

    2013-07-01

    Nuclear reactors and cyclotrons are today the main producing facilities of artificial radioisotopes. These radionuclides are widely used, in particular, in nuclear medicine, such as in radiation therapy (with use of the radioisotope Cobalt-60) and medical imaging (with use of the radioisotope technetium-99). In this framework, the Government of Tunisia has decided to install a sub-critical assembly at CNSTN. This facility will serve as an efficient tool for national human resources development and it will be also extremely useful for carrying out research projects by scientists in order to provide them with a basic understanding of the main concepts relevant to nuclear reactors. The licensing process for the installation of the facility will also bring valuable experience in the development of a nuclear infrastructure in the Country. We propose to summarize in this paper, the basic information concerning the production of radioisotopes with research reactors. We also present the state of art and useful information about the current project to implement a subcritical assembly-reactor in CNSTN (The National Centre for Nuclear Science and Technology). A project carried out with the assistance and the support of the IAEA(The international Atomic Energy Agency)

  2. Omaeluloolisus nullindatel / Estonian Life Writing of the 2000s as a Continuity Over the Post-Soviet Period

    Directory of Open Access Journals (Sweden)

    Rutt Hinrikus

    2013-06-01

    Full Text Available A distinctive feature of the (literary culture of the 2000s is a sudden increase in the publication of works of life writing in different genres. Although life writing as a phenomenon has received considerably more critical attention in recent years, it has not yet settled within the literary canon, and theoretical debates concerning its diverse textual practises are still in initial phases. The current article provides an overview of Estonian life writing of the 2000s, viewing the emergence of new forms, themes and perspectives as a continuity within the wider framework of the post-Soviet period and in comparison with some recent developments and theoretical foci of life writing studies in general.The processes of the construction of subjectivity and identity in a number of autobiographical writings published in the first half of the 2000s can be traced back to the emergence of Estonian “memorial culture” in the late 1980s and 1990s, where oral and written testimonial accounts of personal experience focusing on the period of the Soviet occupation played an important role in the process of dismantling the official Soviet discourses of history and contributed to the process of regaining independence. A number of life writing texts by well-known Estonian literary figures published in the mid-2000s employ modes of collective and individual self-conception and self-reflection similar to those prevalent in the texts of life stories. No longer employed for the purposes of implementing socio-political change, these works confirm and consolidate such modes of identification and self-representation within the framework of (literary culture. Another important trend of Estonian life writing of the 2000s involves “textual games”, where lived experience and the construction of fictional worlds are intertwined in a complex and self-conscious manner. Visible most strongly in the work of Tõnu Õnnepalu and Madis Kõiv, this feature of Estonian life

  3. Seltsi muuseumist riigi keskmuuseumiks: ikka ajutiste lahendustega / Changes in the Estonian National Museum from 1909 to the present.

    Directory of Open Access Journals (Sweden)

    Krista Aru

    2011-01-01

    Full Text Available Changes in the Estonian National Museum from 1909 to the presentThe Estonian National Museum was founded in Tartu in 1909 as part of the national movement. With its activities and connections in society, the ENM helped create Estonian society, the nation’s collective memory and identity.The ENM has always been – despite the changing locations, names, and content – one of the symbols of national identity. But at the same time, ENM has never had its own building designed specially for the museum’s purposes.Since 1909 there have been several attempts to establish a home for the ENM. At first (1909–1923, Estonian society wanted to establish the museum in the center of Tartu. The museum was intended to become a key institution of the growing nation and establishing the nation’s identity.At last in 1923 the ENM secured the Raadi manor, outside the center of the city, in a beautiful park, near the lake with its boats and water attractions. In this manor the first permanent exhibition of mainly 19th century Estonian peasant life was compiled, and the ENM operated in the Raadi manor from 1923–1940 as the “Estonian’s own museum” The years of alternating occupations, World War II, and political terror damaged and destroyed the whole society. The Raadi manor was destroyed in the war too, and the ENM itself was divided into two parts – the State Ethnographic Museum and the State Literary Museum. The collections of the ENM were given to Tallinn and to many different places inside and outside Tartu. Then began “the period of temporary location” that continues today. The museum is located in several places in the city of Tartu.In 1988, the prior name of the State Ethnographic Museum – the Estonian National Museum – was reinstated. Since the 1990s there have been many attempts to secure a special building for the ENM. Now, at last, as a result of serious economic pressure, we are closer to this goal than ever. During the last five

  4. Production and chemical isolation procedure of positron-emitting isotopes of arsenic for environmental and medical applications

    Science.gov (United States)

    Ellison, P. A.; Barnhart, T. E.; Engle, J. W.; Nickles, R. J.; DeJesus, O. T.

    2012-12-01

    The positron-emitting isotopes of arsenic have unique potential for imaging research in medical and environmental applications. The production and purification of radioarsenic from proton-irradiated natural GeO2 targets is reported. The separation procedure utilizes precipitation and anion exchange separation steps. Two anion exchange procedures were investigated. An overall arsenic decay-corrected separation yield of 80% was obtained.

  5. Early assessment of medical technologies to inform product development and market access: A review of methods and applications.

    NARCIS (Netherlands)

    IJzerman, Maarten Joost; Steuten, Lotte Maria Gertruda

    2011-01-01

    Worldwide, billions of dollars are invested in medical product development and there is an increasing pressure to maximize the revenues of these investments. That is, governments need to be informed about the benefits of spending public resources, companies need more information to manage their

  6. Relationship between partnership working and employees’ productivity in a University of Medical Sciences in the South of Iran

    Directory of Open Access Journals (Sweden)

    Mohammad Khammarnia

    2016-07-01

    Full Text Available Introduction: Partnership working plays an important role in the health system, results in delivery of coordinated packages of services to patients, and reduces the impact of organizational fragmentation. Method: The study aimed to determine the relationship between partnership working and productivity in the employees of a university of medical sciences in the south of Iran. Results: According to the result, partnership and productivity scores were 51.1 + 6.7 and 51.9 + 13.4, respectively. Partnership working had a positive relationship with productivity (r = 0.333, P = 0.001 and age of the employees (r = 0.142, P = 0.007. There was a negative relationship between the employees’ productivity with age and job position in ZAUMS (P= 0.009 and P= 0.001, respectively. The nurses had the highest score of productivity (mean=60.7±13.3. Moreover, employees with an Ph.D. degree (9 persons had the highest scores of partnership and productivity in ZAUMS (53.6±3.1 and 56.8±6.3, respectively. Conclusion: Enhancement of partnership working could increase the employees’ productivity in the health system. It is recommended that younger persons should be used in universities of medical science. Moreover, supportive staff should increase their partnership working to enhance the individual and organizational productivity.

  7. Medical Isotopes Production Project: Molybdenum-99 and related isotopes - environmental impact statement. Volume II, comment response document

    International Nuclear Information System (INIS)

    1996-04-01

    This Environmental Impact Statement (EIS) provides environmental and technical information concerning the U.S. Department of Energy's (DOE) proposal to establish a domestic source to produce molybdenum-99 (Mo-99) and related isotopes (iodine-131, xenon-133, and iodine-125). Mo-99, a radioactive isotope of the element molybdenum, decays to form metastable technetium-99 (Tc-99m), a radioactive isotope used thousands of times daily in medical diagnostic procedures in the U.S. Currently, all Mo-99 used in the U.S. is obtained from a single Canadian source. DOE is pursuing the Medical Isotopes Production Project in order to ensure that a reliable supply of Mo-99 is available to the U.S. medical community as soon as practicable. Under DOE's preferred alternative, the Chemistry and Metallurgy Research Facility at the Los Alamos National Laboratory (LANL) and the Annular Core Research Reactor and Hot Cell Facility at Sandia National Laboratories/New Mexico (SNL/NM) would be used for production of the medical isotopes. In addition, three other reasonable alternatives and a No Action alternative are analyzed in detail, The sites for these three reasonable alternatives are LANL, Oak Ridge National Laboratory (ORNL), and Idaho National Engineering Laboratory (INEL). The analyses in this EIS indicate no significant difference in the potential environmental impacts among the alternatives. Each of the alternatives would use essentially the same technology for the production of the medical isotopes. Minor differences in environmental impacts among alternatives relate to the extent of activity necessary to modify and restart (as necessary) existing reactors and hot cell facilities at each of the sites, the quantities of low-level radioactive waste generated, how such waste would be managed, and the length of time needed for initial and full production capacity. This document contains comments recieved from meetings held regarding the site selection for isotope production

  8. Spontaneously Reported Adverse Reactions for Herbal Medicinal Products and Natural Remedies in Sweden 2007-15: Report from the Medical Products Agency.

    Science.gov (United States)

    Svedlund, Erika; Larsson, Maria; Hägerkvist, Robert

    2017-06-01

    In relation to the extensive use of herbal medicinal products in self-care, the safety information is limited and there is a need for improvement. This study describes spontaneously reported adverse reactions related to herbal medicinal products and natural remedies in Sweden. To evaluate the characteristics and frequency of adverse events recorded by the Swedish Medical Products Agency, where herbal medicinal products and natural remedies were suspected as causative agents. Adverse drug reactions reported to the Swedish Medical Product Agency during 2007-15 related to approved herbal medicinal products or natural remedies were included and analysed in the retrospective study. Reports had been assessed for causality when they were lodged and only reports that had been assessed as at least possible were included in the study. In total, 116 reports (concerning 259 adverse reactions) related to herbal medicinal products or natural remedies were found in the Swedish national pharmacovigilance database. The active ingredients most frequently suspected during the study period were black cohosh rhizome (15 reports), purple coneflower herb (14 reports) and a combination of extracts of pollen (13 reports). Adverse reactions related to skin and subcutaneous tissue were the most commonly reported reactions. No previously unknown safety problems have been discovered in the present study. This finding could be explained by a thorough pre-approval assessment of medicinal products and the fact that most herbal preparations in medicinal products have been in clinical use for many years (for traditional herbal medicinal products, the requirements are ≥30 years), i.e. adverse reactions are acknowledged and assessed before approval.

  9. Product Recalls in the Medical Device Industry: An Empirical Exploration of the Sources and Financial Consequences

    OpenAIRE

    Sriram Thirumalai; Kingshuk K. Sinha

    2011-01-01

    Medical devices play an increasingly significant role in the delivery of health care today. However, persistent quality problems with medical devices and the associated recalls present potential health risks to patients and personnel using these devices. This study addresses three key issues in this regard. First, it empirically assesses the financial implications of medical device recalls to understand if these consequences are severe enough to deter firms from introducing potentially hazard...

  10. Genome-Based Studies of Marine Microorganisms to Maximize the Diversity of Natural Products Discovery for Medical Treatments

    Directory of Open Access Journals (Sweden)

    Xin-Qing Zhao

    2011-01-01

    Full Text Available Marine microorganisms are rich source for natural products which play important roles in pharmaceutical industry. Over the past decade, genome-based studies of marine microorganisms have unveiled the tremendous diversity of the producers of natural products and also contributed to the efficiency of harness the strain diversity and chemical diversity, as well as the genetic diversity of marine microorganisms for the rapid discovery and generation of new natural products. In the meantime, genomic information retrieved from marine symbiotic microorganisms can also be employed for the discovery of new medical molecules from yet-unculturable microorganisms. In this paper, the recent progress in the genomic research of marine microorganisms is reviewed; new tools of genome mining as well as the advance in the activation of orphan pathways and metagenomic studies are summarized. Genome-based research of marine microorganisms will maximize the biodiscovery process and solve the problems of supply and sustainability of drug molecules for medical treatments.

  11. Medical/Scientific Illustration And Production Of Otological Health Awareness Materials

    Science.gov (United States)

    Hawes, Nicholas E.

    2004-01-01

    Over the past year, I have worked for my mentor, Beth Cooper, on a large variety of projects. Beth is the Manager of the Acoustical Testing Laboratory, which tests the acoustical emissions of payloads destined for the International Space Station. She is also responsible for educating, and developing new methods of educating, people of all occupational and educational backgrounds in hearing conservation. Beth spends much of her time developing new materials and strategies with which to train people and teach other people to train people in hearing conservation and noise emissions control. I have been helping Beth develop and market these materials by way of graphic design and scientific illustration. Last summer, I spent much of my time creating educational illustrations that visually explained particular concepts in Beth's presentations. Sometimes these illustrations were small "comics" while, at other times, they were an instructional series of illustrations. Since then, Beth and her lab have been developing and updating some materials which will be distributed free to hearing conservation and noise control professionals and others in related fields. I have helped with these projects by designing their packaging. In each instance, it was my responsibility to develop an aesthetically appealing package that would also, through its imagery, describe or summarize the contents of the product. I did this for 3 CD's (Auditory Demonstrations 11, MACSUG, and JeopEARdy) and saw them through their actual production and distribution. In addition to working with Beth, I work with the Imaging Technology Center on various imaging projects. Some of my activities include photo retouching and manipulation for videos and print. This summer, I also had the opportunity to develop a screen saver that would show of some of the photography contained on the soon-to-be-released "Highlights of the GRC Image Archives, vol. 2". I was also able to utilize my medical training to help several of

  12. Broadcast Advertising of Medical Products and Services: Its Regulation by Other Nations.

    Science.gov (United States)

    Powell, Jon T.

    1972-01-01

    Restraints imposed on medical advertising through the broadcast media reflect a worldwide concern for public protection in a sensitive area, where problems of ignorance and misrepresentation are enlarged by false hope. The author examines the broadcast codes of seventeen free-world nations, with respect to their provisions on medical advertising.…

  13. WOSMIP II- Workshop on Signatures of Medical and Industrial Isotope Production

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Murray; Achim, Pascal; Auer, M.; Bell, Randy; Bowyer, Ted W.; Braekers, Damien; Bradley, Ed; Briyatmoko, Budi; Berglund, Helena; Camps, Johan; Carranza, Eduardo C.; Carty, Fitz; DeCaire, Richard; Deconninck, Benoit; DeGeer, Lars E.; Druce, Michael; Friese, Judah I.; Hague, Robert; Hoffman, Ian; Khrustalev, Kirill; Lucas, John C.; Mattassi, G.; Mattila, Aleski; Nava, Elisabetta; Nikkinin, Mika; Papastefanou, Constantin; Piefer, Gregory R.; Quintana, Eduardo; Ross, Ole; Rotty, Michel; Sabzian, Mohammad; Saey, Paul R.; Sameh, A. A.; Safari, M.; Schoppner, Michael; Siebert, Petra; Unger, Klaus K.; Vargas, Albert

    2011-11-01

    Medical and industrial fadioisotopes are fundamental tools used in science, medicine and industry with an ever expanding usage in medical practice where their availability is vital. Very sensitive environmental radionuclide monitoring networks have been developed for nuclear-security-related monitoring [particularly Comprehensive Test-Ban-Treaty (CTBT) compliance verification] and are now operational.

  14. Evaluation of selected ex-reactor accidents related to the tritium and medical isotope production mission at the FFTF

    Energy Technology Data Exchange (ETDEWEB)

    Himes, D.A.

    1997-11-17

    The Fast Flux Test Facility (FFTF) has been proposed as a production facility for tritium and medical isotopes. A range of postulated accidents related to ex-reactor irradiated fuel and target handling were identified and evaluated using new source terms for the higher fuel enrichment and for the tritium and medical isotope targets. In addition, two in-containment sodium spill accidents were re-evaluated to estimate effects of increased fuel enrichment and the presence of the Rapid Retrieval System. Radiological and toxicological consequences of the analyzed accidents were found to be well within applicable risk guidelines.

  15. The Baltic Klint beneath the central Baltic Sea and its comparison with the North Estonian Klint

    Science.gov (United States)

    Tuuling, Igor; Flodén, Tom

    2016-06-01

    Along its contact with the Baltic Shield, the margin of the East European Platform reveals a well-developed, flooded terraced relief. The most striking and consistent set of escarpments at the contact of the Lower Palaeozoic calcareous and terrigenous rocks, known as the Baltic Klint (BK), extends from northwest of Russia to the Swedish island of Öland. Marine seismic reflection profiling in 1990-2004 revealed the central Baltic Sea Klint (BSK) section in detail and enabled comparison of its geology/geomorphology with a classical klint-section onshore, namely the North Estonian Klint (NEK). The conception of the BK onshore, which is based on the land-sea separating terraced relief in northern Estonia, is not fully applicable beneath the sea. Therefore, we consider that the BSK includes the entire terraced Cambrian outcrop. We suggest the term "Baltic Klint Complex" to include the well-terraced margin of the Ordovician limestone outcrop, which is weakly developed in Estonia. Because of a steady lithological framework of the bedrock layers across the southern slope of the Fennoscandian Shield, the central BSK in the western and the NEK in the eastern part of the Baltic Homocline have largely identical morphologies. The North Estonian Ordovician limestone plateau with the calcareous crest of the BK extends across the central Baltic Sea, whereas morphological changes/variations along the Klint base occur due to the east-westerly lithostratigraphic/thickness changes in the siliciclastic Cambrian sequence. The verge of the NEK, located some 30-50 m above sea level, starts to drop in altitude as its east-westerly course turns to northeast-southwest in western Estonia. Further westwards, the BK shifts gradually into southerly deepening (0.1-0.2°) layers as its crest drops to c. 150 m below sea level (b.s.l.) near Gotska Sandön. This course change is accompanied by a considerable decrease in thickness of the platform sedimentary cover, as below the central Baltic Sea the

  16. Characterization of the vaginal micro- and mycobiome in asymptomatic reproductive-age Estonian women.

    Directory of Open Access Journals (Sweden)

    Tiina Drell

    Full Text Available The application of high-throughput sequencing methods has raised doubt in the concept of the uniform healthy vaginal microbiota consisting predominantly of lactobacilli by revealing the existence of more variable bacterial community composition. As this needs to be analyzed more extensively and there is little straightforward data regarding the vaginal mycobiome of asymptomatic women we aimed to define bacterial and fungal communities in vaginal samples from 494 asymptomatic, reproductive-age Estonian women. The composition of the vaginal microbiota was determined by amplifying bacterial 16S rRNA and fungal internal transcribed spacer-1 (ITS-1 regions and subsequently sequencing them using 454 Life Sciences pyrosequencing. We delineated five major bacterial community groups with distinctive diversity and species composition. Lactobacilli were among the most abundant bacteria in all groups, but also members of genus Gardnerella had high relative abundance in some of the groups. Microbial diversity increased with higher vaginal pH values, and was also higher when a malodorous discharge was present, indicating that some of the women who consider themselves healthy may potentially have asymptomatic bacterial vaginosis (BV. Our study is the first of its kind to analyze the mycobiome that colonizes the healthy vaginal environment using barcoded pyrosequencing technology. We observed 196 fungal operational taxonomic units (OTUs, including 16 OTUs of Candida spp., which is more diverse than previously recognized. However, assessing true fungal diversity was complicated because of the problems regarding the possible air-borne contamination and bioinformatics used for identification of fungal taxons as significant proportion of fungal sequences were assigned to unspecified OTUs.

  17. Non-cancer morbidity among Estonian Chernobyl cleanup workers: a register-based cohort study.

    Science.gov (United States)

    Rahu, Kaja; Bromet, Evelyn J; Hakulinen, Timo; Auvinen, Anssi; Uusküla, Anneli; Rahu, Mati

    2014-05-14

    To examine non-cancer morbidity in the Estonian Chernobyl cleanup workers cohort compared with the population sample with special attention to radiation-related diseases and mental health disorders. Register-based cohort study. Estonia. An exposed cohort of 3680 men (cleanup workers) and an unexposed cohort of 7631 men (population sample) were followed from 2004 to 2012 through the Population Registry and Health Insurance Fund database. Morbidity in the exposed cohort compared with the unexposed controls was estimated in terms of rate ratio (RR) with 95% CIs using Poisson regression models. Elevated morbidity in the exposed cohort was found for diseases of the nervous system, digestive system, musculoskeletal system, ischaemic heart disease and for external causes. The most salient excess risk was observed for thyroid diseases (RR=1.69; 95% CI 1.38 to 2.07), intentional self-harm (RR=1.47; 95% CI 1.04 to 2.09) and selected alcohol-related diagnoses (RR=1.25; 95% CI 1.12 to 1.39). No increase in morbidity for stress reactions, depression, headaches or sleep disorders was detected. No obvious excess morbidity consistent with biological effects of radiation was seen in the exposed cohort, with the possible exception of benign thyroid diseases. Increased alcohol-induced morbidity may reflect alcohol abuse, and could underlie some of the higher morbidity rates. Mental disorders in the exposed cohort were probably under-reported. The future challenge will be to study mental and physical comorbidities in the Chernobyl cleanup workers cohort. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

  18. Corporate Governance from the Perspective of Stakeholder Theory and in Light of Perceptions among Estonian Owners and Managers of Relations with Stakeholders / Mari Kooskora

    Index Scriptorium Estoniae

    Kooskora, Mari, 1969-

    2006-01-01

    Äriühingute valitsemise kontseptsioon ja teoreetiline taust; Eesti omanike ja tippjuhtide ootused suhetes erinevate huvigruppidega ning äriühingute valitsemine huvigruppide teooriast lähtudes. Skeem: The stakeholder model. Tabelid: Contractual and community stakeholders; Overview of how perceptions of the main stakeholder groups among Estonian business leaders between 1995-2004 have changed

  19. Economic modelling of the capture-transport-sink scenario of industrial CO2 emissions: The Estonian-Latvian cross-border case study

    NARCIS (Netherlands)

    Shogenova, A.; Shogenov, K.; Pomeranceva, R.; Nulle, I.; Neele, F.; Hendriks, C.

    2011-01-01

    Industrial CO2 emissions and opportunities for CO2 geological storage in the Baltic Region were studied within the EU GeoCapacity project supported by the European Union Framework Programme 6. Estonia produces the largest amounts of CO2 emissions in the region, due to the combustion of Estonian oil

  20. “... if there’s a party, then there’s definitely alcohol”. Construction of partying practices and abstinence in Estonian youth forums

    Directory of Open Access Journals (Sweden)

    Parder Mari-Liisa

    2015-12-01

    Full Text Available AIMS – Adolescents’ abstinence from alcohol has not been much researched in terms of providing suggestions for prevention strategies. This study aims to fill that gap by offering a practice theory-inspired analysis of how the unwritten rules of partying practices are communicated between posters of Estonian youth forums.

  1. Attitudes of Academic Staff towards Their Own Work and towards External Evaluation, from the Perspective of Self-Determination Theory: Estonian Case

    Science.gov (United States)

    Seema, Riin; Udam, Maiki; Mattisen, Heli

    2016-01-01

    The purpose of this study was to ascertain the attitudes of academic staff towards their own work as well as towards external evaluations. The study was based on (1) an analysis of assessment reports of institutional accreditations conducted by the Estonian Quality Agency for Higher and Vocational Education and (2) self-determination theory on…

  2. Euroopa-ihalusest taasiseseisvusperioodi autobiograafiates / European Identifications in Post-Soviet Estonian Life Writing

    Directory of Open Access Journals (Sweden)

    Leena Kurvet-Käosaar

    2016-12-01

    Full Text Available Teesid: Artikkel käsitleb Euroopat kui identiteedi ja minaduse sõlmpunkti ja enesevahenduse mõõdet kolmes omaelulookirjutuslikus teoses, mille autoritel on väljapaistev positsioon eesti (kirjanduskultuuris: Jaan Krossi „Kallid kaasteelised“ (2003a, 2008, Jaan Kaplinski „Isale“ (2003 ja Tõnu Õnnepalu „Flandria päevik“ (2007. Artikkel keskendub sellele, kuidas küsimused suhestumise trajektooridest Euroopa mäluruumiga haakuvad Krossi, Kaplinski ja Õnnepalu teostes esiletuleva enesemääratlusliku raamiga, neist lähtuvate vastastikuse kõnetuse võimaluste ja oma aegruumi tunnetuse pidepunktidega. Kuigi tegemist on eesti keeles ilmunud ning eesti kultuuriruumi lugejale suunatud teostega, seostuvad neis väljajoonistuvad enesemääratluse teljed viimastel aastakümnetel hoogustunud laiemate aruteludega ühtse Euroopa mäluraami ning identiteedi võimalikkusest ja selle toimimise tingimustest.   In recent years, the question of the possibility of a shared frame of memory and identity in Europe, its desired manifestations and practices for attaining it as well as its obstacles and limitations to it have gained prominence in scholarly debates in a number of disciplines. In terms of the division between the East and West of Europe, these discussions take as their starting point the collapse of the Soviet system in 1989 as well as the European Union enlargement in 2004. Far from uniform, the exceedingly complex and contrasting ranges of arguments have put forward a varied palette of perspectives and suggestions about possible and desirable implications of Europe in different socio-political and cultural configurations. Taking these debates as my starting point, the current article offers an analysis of three life writing works by contemporary Estonian authors and intellectuals, Kallid kaasteelised (Dear Fellow Travellers, 2003, 2008 by Jaan Kross, Isale (To My Father, 2003 by Jaan Kaplinski and Flandria päevik (The Flemish Diary

  3. The Supply of Medical Radioisotopes. 2015 Medical Isotope Supply Review: 99Mo/99mTc Market Demand and Production Capacity Projection 2015-2020

    International Nuclear Information System (INIS)

    Charlton, Kevin; )

    2015-08-01

    Medical diagnostic imaging techniques using technetium-99m ( 99m Tc) account for approximately 80% of all nuclear medicine procedures, representing 30-40 million examinations Worldwide every year. Disruptions in the supply chain of these medical isotopes - which have half-lives of 66 hours for molybdenum-99 ( 99 Mo) and only 6 hours for 99m Tc, and thus must be produced continuously - can lead to cancellations or delays in important medical testing services. Unfortunately, supply reliability has been challenged over the past decade due to unexpected shutdowns and extended refurbishment periods at some of the mostly ageing, 99 Mo-producing research reactors and processing facilities. These shutdowns have at times created conditions for extended global supply shortages (e.g. 2009-2010). At the request of its member countries, the Nuclear Energy Agency (NEA) became involved in global efforts to ensure a secure supply of 99 Mo/ 99m Tc. Since June 2009, the NEA and its High-level Group on the Security of Supply of Medical Radioisotopes (HLG-MR) have examined the causes of supply shortages and developed a policy approach, including principles and supporting recommendations to address those causes. The NEA has also reviewed the global 99 Mo supply situation periodically, using the most up-to-date data available from supply chain participants, to highlight periods of potential reduced supply and to underscore the case for implementing the HLG-MR policy approach in a timely and globally consistent manner. In 2012, the NEA released a M o supply and demand forecast up to 2030, identifying periods of potential low supply relative to demand. That 2012 forecast was updated with a report 'Medical Isotope Supply in the Future: Production Capacity and Demand Forecast for the 99 Mo/ 99m Tc Market 2015-2020' (NEA, 2014) in 2014 that focused on the much shorter 2015-2020 period. This report updates the 2014 report, and continues to focus on the potentially critical 2015

  4. Making a Mark—Time Changing Politics from Estonia: An Alternative Idea for the British, Bulgarian and Estonian EU Presidency

    Directory of Open Access Journals (Sweden)

    Fischer Dirk-Hinnerk

    2016-02-01

    Full Text Available Estonia is famous among politicians for its e-Governance policies. One core ingredient for this progress is the abolishment of outdated technologies and standards as this kind of legacy policy slows down the innovation process. This short paper adapts the Estonian approach towards legacy policy and proposes a political symbol initiated by the EU Presidency Trio of the United Kingdom, Bulgaria and Estonia. The entire topic was inspired by the motivation of the Estonian government to use the presidency to make a mark for Estonia. The twice-yearly occurring process of introducing and disabling the summertime, is not only annoying but has also almost exclusively negative impacts. Meanwhile, the summertime itself comes with many aspects of questionable impact and even opposing empirical results, but it also has some generally agreed upon positive influences. This paper takes side against the process of changing times, but does not take position for one of the possible solutions. This short article shall only inform and show the possibilities in regard to the summer time, the EU presidency and the political symbolism of celebrating the centenary of the First World War.

  5. Diversity of Helicobacter pylori genotypes among Estonian and Russian patients with perforated peptic ulcer, living in Southern Estonia.

    Science.gov (United States)

    Sillakivi, T; Aro, H; Ustav, M; Peetsalu, M; Peetsalu, A; Mikelsaar, M

    2001-02-05

    To compare the genomic variation of Helicobacter pylori in samples obtained from patients with perforated peptic ulcer, living in the same area of Estonia but belonging to different nationalities, 50 non-consecutive patients (32 Estonians and 18 Russians) admitted in the Tartu University Hospital in 1997-1999 were studied. Gastric samples of antral mucosa were obtained during operation and analysed histologically and with PCR for detection of different genotypes of H. pylori (cagA and vacA s and m subtypes). Among the 50 perforated peptic ulcer patients with histologically proven H. pylori colonisation no sample of gastric mucosa showed the s1b subtype of the vacA gene. The perforated peptic ulcer patients were mainly infected with cagA (82%) and s1 (98%) genotypes of H. pylori. The distribution of s1a/m1, s1a/m2 and s2/m2 subtypes of vacA genes was statistically different in Estonian and Russian patients (Ppeptic ulcer from Southern Estonia.

  6. Automating the segmentation of medical images for the production of voxel tomographic computational models

    International Nuclear Information System (INIS)

    Caon, M.

    2001-01-01

    Radiation dosimetry for the diagnostic medical imaging procedures performed on humans requires anatomically accurate, computational models. These may be constructed from medical images as voxel-based tomographic models. However, they are time consuming to produce and as a consequence, there are few available. This paper discusses the emergence of semi-automatic segmentation techniques and describes an application (iRAD) written in Microsoft Visual Basic that allows the bitmap of a medical image to be segmented interactively and semi-automatically while displayed in Microsoft Excel. iRAD will decrease the time required to construct voxel models. Copyright (2001) Australasian College of Physical Scientists and Engineers in Medicine

  7. Estonian soil classification as a tool for recording information on soil cover and its matching with local site types, plant covers and humus forms classifications

    Science.gov (United States)

    Kõlli, Raimo; Tõnutare, Tõnu; Rannik, Kaire; Krebstein, Kadri

    2015-04-01

    Estonian soil classification (ESC) has been used successfully during more than half of century in soil survey, teaching of soil science, generalization of soil databases, arrangement of soils sustainable management and others. The Estonian normally developed (postlithogenic) mineral soils (form 72.4% from total area) are characterized by mean of genetic-functional schema, where the pedo-ecological position of soils (ie. location among other soils) is given by means of three scalars: (i) 8 stage lithic-genetic scalar (from rendzina to podzols) separates soils each from other by parent material, lithic properties, calcareousness, character of soil processes and others, (ii) 6 stage moisture and aeration conditions scalar (from aridic or well aerated to permanently wet or reductic conditions), and (iii) 2-3 stage soil development scalar, which characterizes the intensity of soil forming processes (accumulation of humus, podzolization). The organic soils pedo-ecological schema, which links with histic postlithogenic soils, is elaborated for characterizing of peatlands superficial mantle (form 23.7% from whole soil cover). The position each peat soil species among others on this organic (peat) soil matrix schema is determined by mean of 3 scalars: (i) peat thickness, (ii) type of paludification or peat forming peculiarities, and (iii) stage of peat decomposition or peat type. On the matrix of abnormally developed (synlithogenic) soils (all together 3.9%) the soil species are positioned (i) by proceeding in actual time geological processes as erosion, fluvial processes (at vicinity of rivers, lakes or sea) or transforming by anthropogenic and technological processes, and (ii) by 7 stage moisture conditions (from aridic to subaqual) of soils. The most important functions of soil cover are: (i) being a suitable environment for plant productivity; (ii) forming adequate conditions for decomposition, transformation and conversion of falling litter (characterized by humus

  8. Isamaalaulud ja okupatsioonirežiim – nostalgia, utoopia ja reaalsus. Estonian Patriotic Songs and the Occupational Regime – Nostalgia, Utopia and Reality

    Directory of Open Access Journals (Sweden)

    Kanni Labi

    2012-04-01

    Full Text Available Estonian knowledge of history emanates from the fact that constituting an independent nation has for the most part been nothing but a utopia, and was a reality for a relatively short time. When it comes to selfidentification though, the expression ’a singing people’ is often used by the Estonians to describe themselves. Nostalgia for freedom is reflected in the Estonian culture of almost all periods and is carried on by the singing tradition, where patriotic songs emerge independent of different musical tastes within a particular generation and form an important part of a common Estonian repertoire. Patriotic songs occupy a central place in several fields of Estonian culture: besides music culture also in popular culture,and literary history – the works of poetry which have gained the most popularity are those which when put to music have been the most widely spread among the people. The main part of the most popular Estonian patriotic songs are choral songs from the national awakening at the end of the 19th century. Despite the national programmes aiming to wipe out ‘bourgeois nationalism’, they were sung at the song festivals in the Soviet era and were published in song books, expressing the people’s nostalgia for freedom lost. After the end of the Second World War, there was an attempt at launching a kind of patriotic new creation, where patriotism was merged with Soviet pathos; the aim was to show that the people’s utopia was in fact communism, but not a single one of those songs made it into the people’s common repertoire. Only the patriotic songs composed in the 1980s during the so-called new national awakening reached a popularity comparable to that of the old songs. The discourse on ’Estonianness’ and the shaping of a matching repertoire under imperial Russian rule took place under very different circumstances than its preservation and development in the second half of the 20th century under Soviet occupation, but

  9. Radiation chemical technology for production of polymeric hydrogels for medical purposes

    International Nuclear Information System (INIS)

    Mun, G.A.; Nurkeeva, Z.S.; Akhmetkalieva, G.; Sergaziev, A.D.; Petukhov, V.K.; Lyssukhin, S.N.; Chakrov, P.V.

    2003-01-01

    Full text: Polymeric hydrogels are water-swelling cross-linked hydrophilic polymers with ability to store reversibly great amount of water (more than 1000 g of water per 1 g of dry polymer). At present they found a lot of different applications in highly developed countries in science and industry. The set of unique physicochemical and biomedical properties (regulated sorption ability in respect to water and biological liquids, biocompatibility, soft tissue state, permeability in respect to small and big molecules, non-toxicity, etc.) allows their application in medicine. According to the clinical data there are no materials that can compete with hydrogels in development of endo-prostheses of soft-tissues in surgery, contact lenses for eyesight correction, hemo-compatible materials, novel for treatment of wounds and burns, targeted drug delivery systems. Polymeric hydrogels today practically substitute the traditional hydrophobic bases (Vaseline, lanolin) in technology of drug forms for development of ointments and dressings, containing natural and synthetic physiologically active substances. The advantages of hydrogels in comparison with hydrophobic analogues are obvious due to the drainage effect, homogenous distribution of drugs, better contact with wound, painless removing by water washing. The polymeric hydrogels are not produced in Kazakhstan in spite of the big source of raw materials. The aim of the present work is the development of radiation-chemical technology and development of polymeric biomedical hydrogels production based on raw materials of Kazakhstan. The novel types of polymeric hydrogel materials are developed by the authors of the report based on vinyl ethers of glycols, which produced in 'Alash Ltd.' (Temirtau). The great fundamental information content has been obtained about these monomers and polymers including direct quantitative data of their structure formation mechanism and physicochemical properties. These data served as a basis for

  10. Characteristics and evidence of nursing scientific production for medication errors at the hospital environment

    Directory of Open Access Journals (Sweden)

    Lolita Dopico da Silva

    2012-06-01

    Full Text Available This study aimed to identify the characteristics of nurses’ publications about medication errors. It was used an Integrative methodology review covering January 2005 to October 2010 with "medication errors" and "nursing" descriptors and it was also collected data from electronic databases via “Capes Portal”. Results show four categories, the conduct of health professionals in medication errors, types and rates of errors, medication system weaknesses, and barriers to error. Discussion of the prevalent practice was not to notify the error. The prevalent error type was administration and error rates which ranged from 14.8 to 56.7%. Ilegible handwriting, communication failures among professionals, and lack of technical knowledge were weaknesses. Among the barriers, the civility from patient, nurses and technology were evident. Advances in researches for testing barriers were found and some gaps were apparent concerning lack of study that address pharmacodynamics or pharmacokinetic aspects of drugs involved in errors.

  11. Determination of Unknown Neutron Cross Sections for the Production of Medical Isotopes

    Energy Technology Data Exchange (ETDEWEB)

    Stephen E. Binney

    2004-04-09

    Calculational assessment and experimental verification of certain neutron cross sections that are related to widely needed new medical isotopes. Experiments were performed at the Oregon State University TRIGA Reactor and the High Flux Irradiation Reactor at Oak Ridge National Laboratory.

  12. Pay for performance of Estonian family doctors and impact of different practice- and patient-related characteristics on a good outcome: A quantitative assessment.

    Science.gov (United States)

    Merilind, Eero; Salupere, Rauno; Västra, Katrin; Kalda, Ruth

    2016-01-01

    Several practice- and patient-related characteristics are reported to have an influence on a good quality outcome. Estonia started the pay-for-performance (P4P) system for family doctors (FDs) in 2006. Every year the number of FDs participating in P4P has increased, but only half of the FDs achieved good outcome. The aim of this study was to find out which practice- and patient-related characteristics could have an impact on a good outcome. The study was conducted using the database from the Estonian Health Insurance Fund. All working FDs were divided into two groups (with "good" and "poor" outcomes) according their achievements in P4P. We chose characteristics which described structure (practice list size, number of doctors, composition of FDs list: age, number of chronically ill patients) during the observation period 2006-2012. During the observation period 2006-2012, the number of FDs with a good outcome in P4P increased from 6% (2006) to 53% (2012). The high number of FDs in primary care teams, longer experience of participation in P4P and the smaller number of patients on FDs' lists all have an impact on a good outcome. The number of chronically ill patients in FDs lists has no significant effect on an outcome, but P4P increases the number of disease-diagnosed patients. Different practice and patient-related characteristics have an impact on a good outcome. As workload increases, smaller lists of FDs patients or increased staff levels are needed in order to maintain a good outcome. Copyright © 2016 The Lithuanian University of Health Sciences. Production and hosting by Elsevier Urban & Partner Sp. z o.o. All rights reserved.

  13. Role of Radiation Processing in Production of Hydrogels for Medical Applications

    OpenAIRE

    Darwis, D

    2009-01-01

    Recently, hydrophilic polymer gel (hydrogel) for application in medical fields has attracted much attention of researchers due to its unique properties which can resemble human living organs. Wound dressing, contact lenses and drug delivery system are among their applications in medical field. High energy radiation especially gamma ray and electron beam is often used for synthesis and modification of hydrogel. Through radiation crosslinking and or grafting process, hydrogel with specialty pro...

  14. MECHANICAL PROPERTIES OF PARTS OF MEDICAL PRODUCTS PRODUCED USING ADDITIVE MANUFACTURING TECHNOLOGIES

    Directory of Open Access Journals (Sweden)

    Filip Górski

    2017-06-01

    Full Text Available The paper presents results of tests conducted on the elements of medical devices - slings used with medical lifts - manufactured using additive technologies. Project assumptions were: to produce 100 samples of clips with varying design, material and orientation parameter. Samples were manufactured using FDM and SLA processes and then tested for mechanical strength, load transmission and functionality, using certified equipment. Paper shows full methodology and obtained test results.

  15. TU-G-213AB-01: Organization and Productivity Strategies for Practicing Medical Physicists.

    Science.gov (United States)

    Jordan, D

    2012-06-01

    Medical physicists face numerous challenges that create stress in the professional workplace. The modern work environment contains multiple communications channels, such as email, smart phones, text and instant messaging, voice mail, pagers, and more. These media make it difficult to organize incoming information, set priorities, and move important work forward in the face of rapid change and the requirement to fulfill multiple responsibilities. Medical physicists in particular are likely to feel acute stress due to off-peak work hour requirements, varied responsibilities including clinical duties, research, teaching, and regulatory matters, and the complexity of supervising other staff members. Many medical physicists also work in multiple physical locations, adding complexity to the task of organizing information and resources. Another common difficulty is that medical physicists' responsibilities typically include some duties that render them subject to frequent and urgent interruption, such as emergency response coverage for radiation safety. The real challenges in the current medical physics work environment differ from those encountered while taking courses and conducting research, as well as from earlier periods when medical physicists faced fewer varied responsibilities, slower-paced change, or both. Today's practicing physicist can benefit greatly from developing a formal framework and skill set to manage their personal workflow. This greatly increases the individual's effectiveness and reduces feelings of stress, while improving the effectiveness of teams or groups in which they participate. In this session, participants will learn about a number of techniques and strategies to manage their own personal workflow. Examples familiar to the medical physicist will be provided to illustrate methods to capture, organize, and act on important information, to delegate effectively, and to handle inevitable interruptions. 1. Describe the use of a personal workflow

  16. A level-playing field for medical isotope production - How to phase-out reliance on HEU

    International Nuclear Information System (INIS)

    Kuperman, A.J.

    1999-01-01

    Two decades ago, civilian commerce in highly enriched uranium (HEU) for use as targets in the production of medical isotopes was considered a relatively minor security concern for three reasons. First, the number of producers was small. Second, the amount of HEU involved was small. Third, the amount of HEU was dwarfed by the quantities of HEU in civilian commerce as fuel for nuclear research and test reactors. Now, however, all three variables have changed. First, as the use of medical isotopes has expanded rapidly, production programs are proliferating. Second, as the result of such new producers and the expansion of existing production facilities, the amounts of HEU involved are growing. Third, as the RERTR program has facilitated the phase-out of HEU as fuel in most research and test reactors, the quantities of HEU for isotope production have come to represent a significant percentage of global commerce in this weapons-usable material. Medical isotope producers in several states are cooperating with the RERTR program to convert to low-enriched uranium (LEU) targets within the next few years, and one already relies on LEU for isotope production. However, the three biggest isotope producers - in Canada and the European Union - continue to rely on HEU, creating a double-standard that endangers the goal of the RERTR program. Each of these three producers has expressed economic concerns about being put at a competitive disadvantage if it alone converts. This paper proposes forging a firmer international consensus that all present and future isotope producers should convert to LEU, and calls for codifying such a commitment in a statement of intent to be prepared by producers over the next year. With such a level playing field, no producer would need fear being put at a competitive disadvantage by conversion, or being stigmatized by pressure groups for continued reliance on HEU. The phase-out of all HEU commerce for isotope production could be achieved within about

  17. Importance of Radiology among the Spanish medical journal dealing with radiodiagnostics: analysis of their production between 1984 and 1993

    International Nuclear Information System (INIS)

    Martinez, M.; Saez, J.M.; Garcia-Medina, V.

    1997-01-01

    We present a bibliometric analysis of the publications of the journal Radiologia between 1984 and 1993 to contribute to the study of radiodiagnostics reporting in Spain and to determine the importance of Radiologia as a source of information on this subject. We have used the database of the Spanish Medical Index (Indice Medico Espanol, IME) and the journal itself, analyzing the volume, course and distribution of publications on radiodiagnostic procedures. The journal Radiologia publishes 20.1% of the articles dealing with radiology and radiation therapy in Spain. The total number of works was 1,344, that of authors was 2,580 and that of signatures was 6.173, presenting an exponential growth with doubling times of 83.3, 8.5 and 7.4 years, respectively. The analysis shows that the journal's production not only increases over time, but also increments the proportion it contributes to the Spanish medical press as a whole. Radiologia is the most representative journal, in terms of volume of the scientific activity reported in the field of radiodiagnostics in Spain, and its production tends to adapt to the model established for other firmly consolidated scientific and medical disciplines. It alone constitutes the core of the medical journals devoted to radiology and its mean index of circulation according to the IME is 85.79/%. (Author) 34 refs

  18. The Supply of Medical Radioisotopes. 2016 Medical Isotope Supply Review: 99Mo/99mTc Market Demand and Production Capacity Projection 2016-2021

    International Nuclear Information System (INIS)

    Charlton, Kevin; )

    2016-03-01

    Medical diagnostic imaging techniques using technetium-99m ( 99 mTc) account for approximately 80% of all nuclear medicine procedures, representing 30-40 million examinations Worldwide every year. Disruptions in the supply chain of these medical isotopes - which have half-lives of 66 hours for molybdenum-99 ( 99 Mo) and only 6 hours for 99m Tc, and thus must be produced continuously - can lead to cancellations or delays in important medical testing services. Supply reliability has been challenged over the past decade due to unexpected shutdowns and extended refurbishment periods at some of the 99 Mo-producing research reactors and processing facilities. These shutdowns have at times created conditions for extended global supply shortages (e.g. 2009-2010). At the request of its member countries, the Nuclear Energy Agency (NEA) became involved in global efforts to ensure a secure supply of 99 Mo/ 99m Tc. Since June 2009, the NEA and its High-level Group on the Security of Supply of Medical Radioisotopes (HLG-MR) have examined the causes of supply shortages and developed a policy approach, including principles and supporting recommendations to address those causes. The NEA has also reviewed the global 99 Mo supply situation periodically, to highlight periods of potential reduced supply and to underscore the case for implementing the HLG-MR policy approach in a timely and globally consistent manner. In 2012, the NEA released a 99 Mo supply and demand forecast up to 2030, identifying periods of potential low supply relative to demand. That 2012 forecast was updated with a report in 2014 that focused on the much shorter 2015-2020 period. That report was updated in 2015 with a report, '2015 Medical Isotope Supply Review: 99 Mo/ 99m Tc Market Demand and Production Capacity Projection 2015-2020' (NEA, 2015), which focused on the same period. This report updates the 2015 report, and focuses on the important 2016-2021 period. At the end of 2015, the OSIRIS reactor

  19. Early assessment of medical technologies to inform product development and market access: a review of methods and applications.

    Science.gov (United States)

    Ijzerman, Maarten J; Steuten, Lotte M G

    2011-09-01

    Worldwide, billions of dollars are invested in medical product development and there is an increasing pressure to maximize the revenues of these investments. That is, governments need to be informed about the benefits of spending public resources, companies need more information to manage their product development portfolios and even universities may need to direct their research programmes in order to maximize societal benefits. Assuming that all medical products need to be adopted by the heavily regulated healthcare market at one point in time, it is worthwhile to look at the logic behind healthcare decision making, specifically, decisions on the coverage of medical products and decisions on the use of these products under competing and uncertain conditions. With the growing tension between leveraging economic growth through R&D spending on the one hand and stricter control of healthcare budgets on the other, several attempts have been made to apply the health technology assessment (HTA) methodology to earlier stages of technology development and implementation. For instance, horizon scanning was introduced to systematically assess emerging technologies in order to inform health policy. Others have introduced iterative economic evaluation, e.g. economic evaluations in earlier stages of clinical research. However, most of these methods are primarily intended to support governments in making decisions regarding potentially expensive new medical products. They do not really inform biomedical product developers on the probability of return on investment, nor do they inform about the market needs and specific requirements of technologies in development. It is precisely this aspect that increasingly receives attention, i.e. is it possible to use HTA tools and methods to inform biomedical product development and to anticipate further development and market access. Several methods have been used in previous decades, but have never been compiled in a comprehensive review

  20. Productivity Assessment of Physician Assistants and Nurse Practitioners in Oncology in an Academic Medical Center

    OpenAIRE

    Moote, Marc; Nelson, Ron; Veltkamp, Robin; Campbell, Darrell

    2012-01-01

    Productivity measurement for physician assistants and nurse practitioners can be challenging. This study quantifies their productivity in oncology according to economic indicators such as charges and work relative value units.

  1. Eesti autobiograafilise kirjutuse kujunemisest 18. sajandist Teise maailmasõjani. The Development of Estonian Autobiographical Writing from the 18th Century to the Second World War

    Directory of Open Access Journals (Sweden)

    Rutt Hinrikus

    2012-04-01

    Full Text Available In this article I examine the development of Estonian autobiographical writing from its first manifestations to published memoirs, and the development of life writing and its diversification. The beginnings of life writing can be traced back to Estonian folk song and Estonian incidental poetry. The Moravian Brethren movement in Estonia in the 18th century promoted the spread of canonical autobiography. The Moravian Brethren offered alternative opportunities for self-realisation for Estonians who were serfs, and were therefore popular with the people. The practice of the Moravian Brethren made use of retelling and writing about the life of the congregation members, which sometimes became suitable biographies in print, especially stories of awakening. Several manuscript biographies have survived from the Brethren times, such as the biographies of Mäletu Jaan and Mihkel Sarapuu. In addition to the history of the Moravian Brethren movement, these biographies give information about the educational situation and living conditions of the people of the time. The Estonian life writing tradition emerged within the reigning Baltic German cultural space thanks to the Estophiles among the Baltic Germans (J. H. Rosenplänter and the first Estonian men of letters; from the early 19th century we have the diary by Rosenplänter, an estophile pastor from Pärnu, and the diary by the Estonian poet, the then-student Kristjan Jaak Peterson, both in the Estonian language. Johann Voldemar Jannsen, the founder of Estonian-language journalism, kept a diary in the German language for a longer period of time; it was usual that the first Estonian intellectuals (Lilli Suburg, and others in the late 19th century wrote in German. Admittedly, the first Estonian-language life history was written by a forward-looking 19th century peasant named Märt Mitt (1833-1912, who was conscious of himself as a historical subject and gave his memoirs, begun in the 1880s, a memorable title

  2. Development and application of two semi-automated tools for targeted medical product surveillance in a distributed data network.

    Science.gov (United States)

    Connolly, John G; Wang, Shirley V; Fuller, Candace C; Toh, Sengwee; Panozzo, Catherine A; Cocoros, Noelle; Zhou, Meijia; Gagne, Joshua J; Maro, Judith C

    2017-12-01

    An important component of the Food and Drug Administration's Sentinel Initiative is the active post-market risk identification and analysis (ARIA) system, which utilizes semi-automated, parameterized computer programs to implement propensity-score adjusted and self-controlled risk interval designs to conduct targeted surveillance of medical products in the Sentinel Distributed Database. In this manuscript, we review literature relevant to the development of these programs and describe their application within the Sentinel Initiative. These quality-checked and publicly available tools have been successfully used to conduct rapid, replicable, and targeted safety analyses of several medical products. In addition to speed and reproducibility, use of semi-automated tools allows investigators to focus on decisions regarding key methodological parameters. We also identified challenges associated with the use of these methods in distributed and prospective datasets like the Sentinel Distributed Database, namely uncertainty regarding the optimal approach to estimating propensity scores in dynamic data among data partners of heterogeneous size. Future research should focus on the methodological challenges raised by these applications as well as developing new modular programs for targeted surveillance of medical products.

  3. Trends, productivity losses, and associated medical conditions among toxoplasmosis deaths in the United States, 2000-2010.

    Science.gov (United States)

    Cummings, Patricia L; Kuo, Tony; Javanbakht, Marjan; Sorvillo, Frank

    2014-11-01

    Few studies have quantified toxoplasmosis mortality, associated medical conditions, and productivity losses in the United States. We examined national multiple cause of death data and estimated productivity losses caused by toxoplasmosis during 2000-2010. A matched case-control analysis examined associations between comorbid medical conditions and toxoplasmosis deaths. In total, 789 toxoplasmosis deaths were identified during the 11-year study period. Blacks and Hispanics had the highest toxoplasmosis mortality compared with whites. Several medical conditions were associated with toxoplasmosis deaths, including human immunodeficiency virus (HIV), lymphoma, leukemia, and connective tissue disorders. The number of toxoplasmosis deaths with an HIV codiagnosis declined from 2000 to 2010; the numbers without such a codiagnosis remained static. Cumulative disease-related productivity losses for the 11-year period were nearly $815 million. Although toxoplasmosis mortality has declined in the last decade, the infection remains costly and is an important cause of preventable death among non-HIV subgroups. © The American Society of Tropical Medicine and Hygiene.

  4. Medication Errors

    Science.gov (United States)

    ... for You Agency for Healthcare Research and Quality: Medical Errors and Patient Safety Centers for Disease Control and ... Quality Chasm Series National Coordinating Council for Medication Error Reporting and Prevention ... Devices Radiation-Emitting Products Vaccines, Blood & Biologics Animal & ...

  5. Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States.

    Science.gov (United States)

    Cassidy, Laura D; Doney, Brent; Wang, Mei Lin; Kurth, Laura; Conner, Patrick R; Collins, James J; Carson, Michael; Molenaar, Don; Redlich, Carrie A; Storey, Eileen

    2017-12-01

    The aim of this study was to describe a study of medical monitoring methods and lessons learned in detecting health outcomes in U.S. plants producing toluene diisocyanate (TDI). A multidisciplinary team implemented a medical and environmental monitoring program in three TDI plants. Of 269 eligible workers, 197 (73%) participated and 42 (21%) met symptom and/or lung function criteria that would trigger evaluation for possible asthma over 5 years of data collection. Subsequent evaluation was delayed for most, and a web-based data collection system improved timeliness. Medical monitoring of TDI workers identified workers triggering further assessment per study protocol. Systems and/or personnel to ensure rapid follow-up are needed to highlight when triggering events represent potential cases of asthma needing further evaluation. Implementation of a research protocol requires resources and oversight beyond an occupational health program.

  6. Extracurricular scientific production among medical students has increased in the past decade

    DEFF Research Database (Denmark)

    Bech Andersen, Sofie; Østergaard, Lauge; Fosbøl, Philip Loldrup

    2015-01-01

    Introduction: Undergraduate research among medical students is essential in the education of future physicians and scientists. This study aimed to evaluate the scientific yield of extracurricular undergraduate research among medical students. Methods: Medical students at the University of Copenha...... in cardiology (14.1%). Car - diology was also associated with the greatest scientific yield with a median number of 0.8 publications per year after the students concluded their undergraduate research period. Three or more years after concluding their undergraduate research, 32.8% of the students had continued...... specialty and also the specialty with the greatest scientific yield. A third of the undergraduate re - search students continued doing research in the context of a PhD programme....

  7. Do March-In Rights Ensure Access to Medical Products Arising From Federally Funded Research? A Qualitative Study.

    Science.gov (United States)

    Treasure, Carolyn L; Avorn, Jerry; Kesselheim, Aaron S

    2015-12-01

    The high cost of new prescription drugs and other medical products is a growing health policy issue. Many of the most transformative drugs and vaccines had their origins in public-sector funding to nonprofit research institutions. Although the Bayh-Dole Act of 1980 provides for "march-in rights" through which the government can invoke some degree of control over the patents protecting products developed from public funding to ensure public access to these medications, the applicability of this provision to current policy options is not clear. We conducted a primary-source document review of the Bayh-Dole Act's legislative history as well as of hearings of past march-in rights petitions to the National Institutes of Health (NIH). We then conducted semistructured interviews of 12 key experts in the march-in rights of the Bayh-Dole Act to identify the sources of the disputes and the main themes in the statute's implementation. We analyzed the interview transcripts using standard qualitative techniques. Since 1980, the NIH has fully reviewed only 5 petitions to invoke governmental march-in rights for 4 health-related technologies or medical products developed from federally funded research. Three of these requests related to reducing the high prices of brand-name drugs, one related to relieving a drug shortage, and one related to a potentially patent-infringing medical device. In each of these cases, the NIH rejected the requests. Interviewees were split on the implications of these experiences, finding the NIH's reluctance to implement its march-in rights to be evidence of either a system working as intended or of a flawed system needing reform. The Bayh-Dole Act's march-in rights continue to be invoked by policymakers and health advocates, most recently in the context of new,high-cost products originally discovered with federally funded research. We found that the existence of march-in rights may select for government research licensees more likely to commercialize

  8. Research productivity of Pakistan in medical sciences during the period 1996-2012.

    Science.gov (United States)

    Meo, S A; Almasri, A A; Usmani, A M

    2013-11-01

    This study aimed to investigate the degree of research outcome in medical science subjects in Pakistan during the period 1996-2012. In this study, the research papers published in various global science journals during the period 1996-2012 were accessed. We recorded the total number of research documents having an affiliation with a Pakistan. The main source for information was Institute of Scientific Information (ISI) Web of Science, Thomson Reuters and SCI-mago/Scopus. In global science, Pakistan contributed 58133 research papers in all science and social sciences both in ISI and non ISI indexed journals. However, in medical sciences the total number of research papers from Pakistan are 25604, citable documents 23874, citations 128061, mean citations per documents 6.45 and mean Hirsch index is 35.33. In Pakistan, the upward trend of articles published in global medical science was from the period 1996-2008. However, from 2008 the trend is markedly declined. Pakistan significantly improved its international ranking positions in research during the period 2000-2008. However, the upward trend of research papers published in global medical science could not be retained and from the year 2008 the trend started declining. This trend of research papers further declined in year 2012 compared to year 2011. It is suggested that, Pakistan must take strategic steps to enhance the research culture and increase the research and development expenditure in the country.

  9. 78 FR 12329 - Distinguishing Medical Device Recalls From Product Enhancements; Reporting Requirements; Draft...

    Science.gov (United States)

    2013-02-22

    ... unsafe medical devices. FDA also recognizes that continuous improvement activities, as part of an... . Submit written comments to the Division of Dockets Management (HFA-305), Food and Drug Administration... device failure or function. The recall process establishes a mechanism for firms that produce and market...

  10. Formation of Toxic Iodinated Disinfection By-Products from Compounds Used in Medical Imaging

    Science.gov (United States)

    Iodinated X-ray contrast media (ICM) were investigated as a source of iodine in the formation of iodo-trihalomethane (iodo-THM) and iodo-acid disinfection byproducts (DBPs), both of which are highly genotoxic and/or cytotoxic in mammalian cells. ICM are widely used at medical cen...

  11. Assessment of the production of medical isotopes using the Monte Carlo code FLUKA: Simulations against experimental measurements

    Science.gov (United States)

    Infantino, Angelo; Oehlke, Elisabeth; Mostacci, Domiziano; Schaffer, Paul; Trinczek, Michael; Hoehr, Cornelia

    2016-01-01

    The Monte Carlo code FLUKA is used to simulate the production of a number of positron emitting radionuclides, 18F, 13N, 94Tc, 44Sc, 68Ga, 86Y, 89Zr, 52Mn, 61Cu and 55Co, on a small medical cyclotron with a proton beam energy of 13 MeV. Experimental data collected at the TR13 cyclotron at TRIUMF agree within a factor of 0.6 ± 0.4 with the directly simulated data, except for the production of 55Co, where the simulation underestimates the experiment by a factor of 3.4 ± 0.4. The experimental data also agree within a factor of 0.8 ± 0.6 with the convolution of simulated proton fluence and cross sections from literature. Overall, this confirms the applicability of FLUKA to simulate radionuclide production at 13 MeV proton beam energy.

  12. Medical student perceptions of factors affecting productivity of problem-based learning tutorial groups: does culture influence the outcome?

    Science.gov (United States)

    Das Carlo, Mandira; Swadi, Harith; Mpofu, Debbie

    2003-01-01

    The popularization of problem-based learning (PBL) has drawn attention to the motivational and cognitive skills necessary for medical students in group learning. This study identifies the effect of motivational and cognitive factors on group productivity of PBL tutorial groups. A self-administered questionnaire was completed by 115 students at the end of PBL tutorials for 4 themes. The questionnaire explored student perceptions about effect of motivation, cohesion, sponging, withdrawal, interaction, and elaboration on group productivity. We further analyzed (a) differences in perceptions between male and female students, (b) effect of "problems," and (c) effect of student progress over time on group productivity. There were linear relations between a tutorial group's success and the factors studied. Significant differences were noted between male and female student groups. Students and tutors need to recognize symptoms of ineffective PBL groups. Our study emphasizes the need to take into account cultural issues in setting ground rules for PBL tutorials.

  13. Local production of medical technologies and its effect on access in low and middle income countries: a systematic review of the literature

    Science.gov (United States)

    Kaplan, Warren Allan; Ritz, Lindsay Sarah; Vitello, Marie

    2011-01-01

    Objectives: The objective of this study was to assess the existing theoretical and empirical literature examining the link between "local production" of pharmaceuticals and medical devices and increased local access to these products. Our preliminary hypothesis is that studies showing a robust relationship between local production and access to medical products are sparse, at best. Methods: An extensive literature search was conducted using a wide variety of databases and search terms intending to capture as many different aspects of this issue as possible. The results of the search were reviewed and categorized according to their relevance to the research question. The literature was also reviewed to determine the rigor used to examine the effects of local production and what implications these experiences hold for other developing countries. Results: Literature addressing the benefits of local production and the link between it and access to medical products is sparse, mainly descriptive and lacking empirical evidence. Of the literature we reviewed that addressed comparative economics and strategic planning of multinational and domestic firms, there are few dealing with emerging markets and lower-middle income countries and even fewer that compare local biomedical producers with multinational corporations in terms of a reasonable metric. What comparisons exist mainly relate to prices of local versus foreign/multinational produced medicines. Conclusions: An assessment of the existing theoretical and empirical literature examining the link between "local production" of pharmaceuticals and medical devices and increased local access to these products reveals a paucity of literature explicitly dealing with this issue. Of the literature that does exist, methods used to date are insufficient to prove a robust relationship between local production of medical products and access to these products. There are mixed messages from various studies, and although the studies may

  14. Scientific production of Shahid Beheshti University of Medical Sciences in Web of Science between 2011-2014

    Directory of Open Access Journals (Sweden)

    Narges Malih

    2016-02-01

    Full Text Available Background: Along with the prospers of scientific production there is a need for measuring and evaluation of university’ s scientific productions by means of accepted international indices to make comparison between academic institutions. This study aims to evaluate the scientific production of faculty members affiliated to Shahid Beheshti University of Medical Sciences (SBMUS in Web of Science from 2011 to 2014.Methods: This was a descriptive cross-sectional study. Faculty members of Shahid Beheshti University of medical sciences from last updated list of faculty members based on human source management of the university was evaluated. The evaluation criteria was total number of the articles, total number of the articles between 2011-2014, total article’s citations, total article’s citations between 2011-2014 and H Index was extracted from the Web of Science webpage. Results:Totally 1300 faculty members had been evaluated in the study. Scientific productions had an increasing trend from 2011 to 2014. There had been 6445 articles and 41120 citations with a Mean (SD of 4.96 (1.22 and 31.63 (122.5 respectively. Mean H Index of the university was 2.2. School of Pharmacy had the highest H Index score (4.9.Conclusion:There has been an increasing trend in scientific production of SBMUS in Web of Science data base. As Iran is between the first three high ranked countries in the Middle East in based scientometric indices, monitoring of scientific production by yearly intervals seems necessary.Keywords: Cross-Sectional Studies; Faculty; Universities

  15. Identification and analysis of labor productivity components based on ACHIEVE model (case study: staff of Kermanshah University of Medical Sciences).

    Science.gov (United States)

    Ziapour, Arash; Khatony, Alireza; Kianipour, Neda; Jafary, Faranak

    2014-12-15

    Identification and analysis of the components of labor productivity based on ACHIEVE model was performed among employees in different parts of Kermanshah University of Medical Sciences in 2014. This was a descriptive correlational study in which the population consisted of 270 working personnel in different administrative groups (contractual, fixed- term and regular) at Kermanshah University of Medical Sciences (872 people) that were selected among 872 people through stratified random sampling method based on Krejcie and Morgan sampling table. The survey tool included labor productivity questionnaire of ACHIEVE. Questionnaires were confirmed in terms of content and face validity, and their reliability was calculated using Cronbach's alpha coefficient. The data were analyzed by SPSS-18 software using descriptive and inferential statistics. The mean scores for labor productivity dimensions of the employees, including environment (environmental fit), evaluation (training and performance feedback), validity (valid and legal exercise of personnel), incentive (motivation or desire), help (organizational support), clarity (role perception or understanding), ability (knowledge and skills) variables and total labor productivity were 4.10±0.630, 3.99±0.568, 3.97±0.607, 3.76±0.701, 3.63±0.746, 3.59±0.777, 3.49±0.882 and 26.54±4.347, respectively. Also, the results indicated that the seven factors of environment, performance assessment, validity, motivation, organizational support, clarity, and ability were effective in increasing labor productivity. The analysis of the current status of university staff in the employees' viewpoint suggested that the two factors of environment and evaluation, which had the greatest impact on labor productivity in the viewpoint of the staff, were in a favorable condition and needed to be further taken into consideration by authorities.

  16. Quantifying the robustness of process manufacturing concept – A medical product case study

    DEFF Research Database (Denmark)

    Boorla, Srinivasa Murthy; Troldtoft, M.E.; Eifler, Tobias

    2017-01-01

    Product robustness refers to the consistency of performance of all of the units produced. It is often the case that process manufactured products are not designed concurrently, so by the end of the product design phase the Process Manufacturing Concept (PMC) has yet to be decided. Allocating...... process capable tolerances to the product during the design phase is therefore not possible. The robustness of the concept (how capable it is to achieve the product specification), only becomes clear at this late stage and thus after testing and iteration. In this article, a method for calculating....... The case also demonstrates that higher robustness is possible even at higher parameter variability with suitable measurements and adjustability....

  17. Study on 3D printer production of auxiliary device for upper limb for medical imaging test

    International Nuclear Information System (INIS)

    Kim, Hyeong Gyun; Yoon, Jae Ho; Choi, Seong Dae

    2015-01-01

    There is a progressive development in the medical imaging technology, especially of descriptive capability for anatomical structure of human body thanks to advancement of information technology and medical devices. But however maintenance of correct posture is essential for the medical imaging checkup on the shoulder joint requiring rotation of the upper limb due to the complexity of human body. In the cases of MRI examination, long duration and fixed posture are critical, as failure to comply with them leads to minimal possibility of reproducibility only with the efforts of the examiner and will of the patient. Thus, this study aimed to develop an auxiliary device that enables rotation of the upper limb as well as fixing it at quantitative angles for medical imaging examination capable of providing diagnostic values. An auxiliary device has been developed based on the results of precedent studies, by designing a 3D model with the CATIA software, an engineering application, and producing it with the 3D printer. The printer is Objet350 Connex from Stratasys, and acrylonitrile- butadiene-styrene(ABS) is used as the material of the device. Dimensions are 120 X 150 X 190 mm, with the inner diameter of the handle being 125.9 mm. The auxiliary device has 4 components including the body (outside), handle (inside), fixture terminal and the connection part. The body and handle have the gap of 2.1 mm for smooth rotation, while the 360 degree of scales have been etched on the handle so that the angle required for observation may be recorded per patient for traceability and dual examination

  18. Study on 3D printer production of auxiliary device for upper limb for medical imaging test

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyeong Gyun [Dept. of Radiological Science, Far East University, Eumsung (Korea, Republic of); Yoon, Jae Ho [Jukwang Precision Co., Ltd., Gumi (Korea, Republic of); Choi, Seong Dae [Dept. of Mechanical system engineering, Kumoh Institute of Technology, Gumi (Korea, Republic of)

    2015-12-15

    There is a progressive development in the medical imaging technology, especially of descriptive capability for anatomical structure of human body thanks to advancement of information technology and medical devices. But however maintenance of correct posture is essential for the medical imaging checkup on the shoulder joint requiring rotation of the upper limb due to the complexity of human body. In the cases of MRI examination, long duration and fixed posture are critical, as failure to comply with them leads to minimal possibility of reproducibility only with the efforts of the examiner and will of the patient. Thus, this study aimed to develop an auxiliary device that enables rotation of the upper limb as well as fixing it at quantitative angles for medical imaging examination capable of providing diagnostic values. An auxiliary device has been developed based on the results of precedent studies, by designing a 3D model with the CATIA software, an engineering application, and producing it with the 3D printer. The printer is Objet350 Connex from Stratasys, and acrylonitrile- butadiene-styrene(ABS) is used as the material of the device. Dimensions are 120 X 150 X 190 mm, with the inner diameter of the handle being 125.9 mm. The auxiliary device has 4 components including the body (outside), handle (inside), fixture terminal and the connection part. The body and handle have the gap of 2.1 mm for smooth rotation, while the 360 degree of scales have been etched on the handle so that the angle required for observation may be recorded per patient for traceability and dual examination.

  19. Acrylamide in food products – eating habits and consumer awareness among Medical School students

    Directory of Open Access Journals (Sweden)

    Małgorzata Kowalska

    2017-12-01

    Due to the adverse effects of this compound it is important to reduce the level of acrylamide in food products. A few people in the population (7% had heard of acrylamide previously, but none of them had any knowledge of its occurrence and formation. It is necessary to take strong action to change attitudes towards acrylamide and attempt to introduce ways to reduce this compound in the diet, for example, by appropriate selection of products in the daily diet and appropriate means of thermal preparation of products at home.

  20. Medical use of cannabis and cannabinoids containing products - Regulations in Europe and North America.

    Science.gov (United States)

    Abuhasira, Ran; Shbiro, Liat; Landschaft, Yuval

    2018-03-01

    In 1937, the United States of America criminalized the use of cannabis and as a result its use decreased rapidly. In recent decades, there is a growing interest in the wide range of medical uses of cannabis and its constituents; however, the laws and regulations are substantially different between countries. Laws differentiate between raw herbal cannabis, cannabis extracts, and cannabinoid-based medicines. Both the European Medicines Agency (EMA) and the United States Food and Drug Administration (FDA) do not approve the use of herbal cannabis or its extracts. The FDA approved several cannabinoid-based medicines, so did 23 European countries and Canada. However, only four of the reviewed countries have fully authorized the medical use of herbal cannabis - Canada, Germany, Israel and the Netherlands, together with more than 50% of the states in the United States. Most of the regulators allow the physicians to decide what specific indications they will prescribe cannabis for, but some regulators dictate only specific indications. The aim of this article is to review the current (as of November 2017) regulations of medical cannabis use in Europe and North America. Copyright © 2018 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

  1. Abortion choices among women in Cambodia after introduction of a socially marketed medicated abortion product.

    Science.gov (United States)

    Sotheary, Khim; Long, Dianna; Mundy, Gary; Madan, Yasmin; Blumenthal, Paul D

    2017-02-01

    To assess whether a social marketing initiative focusing on medicated abortion via a mifepristone/misoprostol "combipack" has contributed to reducing unsafe abortion in Cambodia. In a questionnaire-based cross-sectional study, annual household surveys were conducted across 13 Cambodian provinces in 2010, 2011, and 2012. One married woman of reproductive age who was not pregnant and did not wish to be within the next 2 years in each randomly selected household was approached for inclusion. Participants were interviewed using a structured questionnaire. The questionnaire was completed by 1843 women in 2010, 2068 in 2011, and 2059 in 2012. Manual vacuum aspiration was reported by 61 (72.6%) of 84 women surveyed in 2010 who reported an abortion in the previous 12 months, compared with only 28 (52.8%) of 53 in 2012 (P=0.001). The numbers of women undergoing medicated abortion increased from 22 (26.2%) of 84 in 2010 to 27 (49.1%) of 53 in 2012 (P=0.003), whereas the numbers undergoing unsafe abortion decreased from 4 (4.8%) in 2010 to 0 in 2012 (P=0.051). Social marketing of medication abortion coupled with provider training in clinical and behavioral change could have contributed to a reduction in the prevalence of unsafe abortion and shifted the types of abortion performed in Cambodia, while not increasing the overall number of abortions. © 2016 International Federation of Gynecology and Obstetrics.

  2. Review of Cyclotrons for the Production of Radioactive Isotopes for Medical and Industrial Applications

    Science.gov (United States)

    Schmor, Paul

    2011-02-01

    Radioactive isotopes are used in a wide range of medical, biological, environmental and industrial applications. Cyclotrons are the primary tool for producing the shorter-lived, proton-rich radioisotopes currently used in a variety of medical applications. Although the primary use of the cyclotron-produced short-lived radioisotopes is in PET/CT (positron emission tomography/computed tomography) and SPECT (single photon emission computed tomography) diagnostic medical procedures, cyclotrons are also producing longer-lived isotopes for therapeutic procedures as well as for other industrial and applied science applications. Commercial suppliers of cyclotrons are responding by providing a range of cyclotrons in the energy range of 3-70MeV for the differing needs of the various applications. These cyclotrons generally have multiple beams servicing multiple targets. This review article presents some of the applications of the radioisotopes and provides a comparison of some of the capabilities of the various current cyclotrons. The use of nuclear medicine and the number of cyclotrons supplying the needed isotopes are increasing. It is expected that there will soon be a new generation of small "tabletop" cyclotrons providing patient doses on demand.

  3. Medical decision making and risky choices: psychological and medicolegal consequences of HIV and HCV contamination of blood products

    Directory of Open Access Journals (Sweden)

    Riva S

    2017-08-01

    Full Text Available S Riva,1 S Del Sordo,2,3 U Genovese,1,3 G Pravettoni1 1Department of Oncology and Hemato-oncology, University of Milan, Italy; 2FOLSATEC (Foundations & Ethics of the Life Sciences PhD School, University of Milan, Milan, Italy; 3Healthcare Accountability Lab, University of Milan, Milan, Italy Aims: The overall goal of this article is to make a scientific comment about the psycho-social consequences of hemophilia patients affected by human immunodeficiency virus (HIV and/or hepatitis C virus (HCV and to point out the related medicolegal issues. Methods: This commentary takes into account some published evidences about the current scenario of hemophilia patients infected by HIV and/or HCV who received contaminated blood products in the late 1970s through 1985. Results: Several psychological and medicolegal consequences are related with HIV and HCV contamination of blood products. A multidisciplinary approach is needed to treat all the difficulties experienced by these patients and to ensure good clinical decisions in medical practice. Conclusion: The literature on the psychosocial functioning of hemophilia patients with human HIV and HCV infection offers a number of implications, including medicolegal issues, that can be discussed for guaranteeing a good level of care and safeguard of this group of patients. Keywords: hemophilia, viral contaminated blood products, monetary compensation, medico-legal issues, medical decision making

  4. The NNSA global threat reduction initiative's efforts to minimize the use of highly enriched uranium for medical isotope production

    International Nuclear Information System (INIS)

    Staples, Parrish

    2010-01-01

    The mission of the National Nuclear Security Administration's (NNSA) Office of Global Threat Reduction (GTRI) is to reduce and protect vulnerable nuclear and radiological materials located at civilian sites worldwide. GTRI is a key organization for supporting domestic and global efforts to minimize and, to the extent possible, eliminate the use of highly enriched uranium (HEU) in civilian nuclear applications. GTRI implements the following activities in order to achieve its threat reduction and HEU minimization objectives: Converting domestic and international civilian research reactors and isotope production facilities from the use of HEU to low enriched uranium (LEU); Demonstrating the viability of medical isotope production technologies that do not use HEU; Removing or disposing excess nuclear and radiological materials from civilian sites worldwide; and Protecting high-priority nuclear and radiological materials worldwide from theft and sabotage. This paper provides a brief overview on the recent developments and priorities for GTRI program activities in 2010, with a particular focus on GTRI's efforts to demonstrate the viability of non-HEU based medical isotope production technologies. (author)

  5. Chemical composition of anthropogenic particles on needles collected close to the Estonian oil-shale power plants

    International Nuclear Information System (INIS)

    Meinander, O.

    1995-01-01

    Within the countries surrounding the Baltic Sea, north-eastern Estonia is among the most polluted areas. Emissions from the oil-shale power plants produce air pollution problems both locally and on a larger scale. In the atmosphere, pollutants mix and convert. Consequently, the particles deposited due to the use of oil-shale can have various chemical compositions. From the point of view of air chemistry, ecological effects and air pollution modelling, knowledge of the chemical composition of the deposited particles can be of great value. The aim of this work was to study the chemical composition of single anthropogenic particles occurring on needle surfaces in north-eastern Estonia and Southern Finland close to the Estonian oil-shale power plants. For the purpose, scanning electron microscopical microanalysis was used

  6. Iseseisvusdeklaratsioonid 1776–1918. The Estonian Declaration of Sovereignty: An Example of the Civilizing Force of Hypocrisy

    Directory of Open Access Journals (Sweden)

    Hent Kalmo

    2012-06-01

    Full Text Available Sovereignty has been characterised as a form of “organized hypocrisy”, a system governed by a set of rules that are generally recognised as binding and yet are continually infringed upon by the most powerful actors. This idea can be extended to analyse the role of sovereignty within the Soviet Union. The Soviet Union was nominally governed by a Constitution which endowed the Union Republics with the right of secession, but there was no realistic possibility of exercising this right. One should not rush to conclude, however, that the actual wording of the Soviet Constitution of 1977 was entirely without relevance. As Jon Elster has argued, hypocrisy can have a “civilizing force” when the need to appear impartial and to retain public credibility forces actors to choose a strategy they would not choose otherwise. A good example of this kind of argumentative constraint is offered by the dilemma faced by the Soviet leadership after the mid-1980s, as it became reluctant to use military force to suppress independence movements within the Baltic States while, at the same time, promising to give more weight to the Soviet Constitution and respect the “sovereignty” of the Union Republics. In this setting, the ambiguity of the word “sovereignty” could be played upon by a whole gamut of political movements in order to further their agenda, from local communists eager to expand their autonomy within the Soviet system to those making an explicit bid for the restoration of independence. Significant legal and political changes could be justified as mere conclusions from the constitutionally recognised status of the Union Republics – a strategy which was all the more effective as Moscow struggled to formulate an alternative line of constitutional interpretation that could be used to counter the Baltic claims. This exchange of opinions escalated into a constitutional conflict in November 1988, when the Estonian Supreme Soviet responded to

  7. Production of high specific activity 123I for protein iodination for medical use

    International Nuclear Information System (INIS)

    Legoux, Y.; Cieur, M.; Crouzel, C.; Syrota, A.

    1985-01-01

    Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients. (author)

  8. The Navy Medical Technology Watch: Hemostatic Dressing Products for the Battlefield

    Science.gov (United States)

    2006-09-09

    for surgical procedures Availability may be limited Absorbable Potato starch based. The potato starch coagulant base is derived by synthesizing...bleeding while in transit to a field MTF, hospital, or trauma center. Product: TraumaDEX; Medafor, Inc., Minneapolis, MN 55430 Potato starch based...wounds and to stop bleeding due to oral surgery and tooth extractions . Biolife product literature states a 96% success rate in an ongoing clinical study

  9. Individual and work-related risk factors for musculoskeletal pain: a cross-sectional study among Estonian computer users

    Science.gov (United States)

    2014-01-01

    Background Occupational use of computers has increased rapidly over recent decades, and has been linked with various musculoskeletal disorders, which are now the most commonly diagnosed occupational diseases in Estonia. The aim of this study was to assess the prevalence of musculoskeletal pain (MSP) by anatomical region during the past 12 months and to investigate its association with personal characteristics and work-related risk factors among Estonian office workers using computers. Methods In a cross-sectional survey, the questionnaires were sent to the 415 computer users. Data were collected by self-administered questionnaire from 202 computer users at two universities in Estonia. The questionnaire asked about MSP at different anatomical sites, and potential individual and work related risk factors. Associations with risk factors were assessed by logistic regression. Results Most respondents (77%) reported MSP in at least one anatomical region during the past 12 months. Most prevalent was pain in the neck (51%), followed by low back pain (42%), wrist/hand pain (35%) and shoulder pain (30%). Older age, right-handedness, not currently smoking, emotional exhaustion, belief that musculoskeletal problems are commonly caused by work, and low job security were the statistically significant risk factors for MSP in different anatomical sites. Conclusions A high prevalence of MSP in the neck, low back, wrist/arm and shoulder was observed among Estonian computer users. Psychosocial risk factors were broadly consistent with those reported from elsewhere. While computer users should be aware of ergonomic techniques that can make their work easier and more comfortable, presenting computer use as a serious health hazard may modify health beliefs in a way that is unhelpful. PMID:24884911

  10. Tõlkepärl eesti ilukirjanduse algusaegadest – esimene eestikeelne robinsonaad / A Translation Gem from the Beginnings of Estonian Literature - the First Robinsonade

    Directory of Open Access Journals (Sweden)

    Ave Mattheus

    2015-06-01

    Full Text Available Teesid: Artiklis uuritakse Eesti Kirjandusmuuseumis asuvat mahukat, ligi 800 lk tõlkekäsikirja „Norem Robinson“, mida võib pidada esimeseks eesti kirjanduse täiemahuliseks robinsonaadiks. Selle valmistas Pärnu koolmeister Heinrich Gottlieb Lorenzsonn saksa pedagoogi ja koolikirjaniku Joachim Heinrich Campe menukast noorsooromaanist „Robinson der Jüngere“ (1779–1780. Tõlge valmis 1822.–1823. aastal, kuid jõudis trükki alles 1842. aastal tugevasti kärbitud ja mugandatud kujul. Toetudes deskriptiivse tõlkeuurimuse analüüsikategooriatele, vaadeldakse artiklis, millised tegurid tõlkeprotsessi suunasid ja milline oli kultuuriruum, kuhu tõlge omal ajal paigutus. SU M M A R Y This article discusses a voluminous manuscript translation of almost 800 pages entitled Norem Robinson (Engl. Robinson the Younger, from the collections of the Estonian Literary Museum. This manuscript can be considered as the first complete Robinsonade in Estonian literature. Its author is a schoolteacher from Pärnu, Heinrich Gottlieb Lorenzsonn (1803–1847, who translated it from the youth novel Robinson der Jüngere(1779–1780, Engl. Robinson the Younger, a bestseller by the educator, writer and a major representative of German Enlightenment, Heinrich Joachim Campe. Lorenzsonn’s translation was completed in 1822–1823, but not printed until 1842 in a strongly adapted version titled Norema Robinsoni ello ja juhtumised ühhe tühja sare peäl (Engl. The Life and Adventures of Robinson the Younger on a deserted island. The print version of the Robinsonade lacks a pedagogical frame story, where the father tells children about the adventures of Robinson and takes the opportunity to discuss and imitate with children all the actions taken by Robinson the Younger. Due to this and other extirpated parts, the possible target audience was enlarged – besides children and youth, the text was now addressed to adults as well. In accordance with the

  11. IAEA coordinated research project on nuclear data for charged-particle monitor reactions and medical isotope production

    Science.gov (United States)

    Capote, Roberto; Nichols, Alan L.; Nortier, Francois Meiring; Carlson, Brett V.; Engle, Jonathan W.; Hermanne, Alex; Hussain, Mazhar; Ignatyuk, Anatoly V.; Kellett, Mark A.; Kibédi, Tibor; Kim, Guinyun; Kondev, Filip G.; Lebeda, Ondrej; Luca, Aurelian; Naik, Haladhara; Nagai, Yasuki; Spahn, Ingo; Suryanarayana, Saraswatula V.; Tárkányi, Ferenc T.; Verpelli, Marco

    2017-09-01

    An IAEA coordinated research project was launched in December 2012 to establish and improve the nuclear data required to characterise charged-particle monitor reactions and extend data for medical radionuclide production. An international team was assembled to undertake work addressing the requirements for more accurate cross-section data over a wide range of targets and projectiles, undertaken in conjunction with a limited number of measurements and more extensive evaluations of the decay data of specific radionuclides. These studies are nearing completion, and are briefly described below.

  12. Production cross-sections for charged particle interactions in matter relevant to bio-medical applications

    International Nuclear Information System (INIS)

    Reading, D.H.

    1978-01-01

    Pion, proton and heavy ion beams are used extensively in bio-medical applications, the attraction being the high proportion of heavily ionizing short range secondaries localized at the stopping region, giving rise to a greater dose being deposited at the end of the range. However interactions in flight reduce the advantage either by deflection or absorption and thus the dose measurement is insufficient to model biological effects due to the changing radiation quality. Experimental investigations of such interactions are here reviewed and the experimental data arising examined in respect of input to models for radiobiology and treatment planning. 78 references. (U.K.)

  13. Increasing Department of Surgery Productivity: A Study on the Effects of Adding an Ambulatory Surgery Room to Tripler Army Medical Center

    National Research Council Canada - National Science Library

    Vaseliades, Aristotle A

    2006-01-01

    ...) to increase productivity in terms of relative value units (RVUs). Tripler Army Medical Center submitted 12 initiatives, one of which was the implementation of an ambulatory surgery room within the Department of Surgery...

  14. Some nuclear chemical aspects of medical generator nuclide production at the Los Alamos hot cell facility

    CERN Document Server

    Fassbender, M; Heaton, R C; Jamriska, D J; Kitten, J J; Nortier, F M; Peterson, E J; Phillips, D R; Pitt, L R; Salazar, L L; Valdez, F O; 10.1524/ract.92.4.237.35596

    2004-01-01

    Generator nuclides constitute a convenient tool for applications in nuclear medicine. In this paper, some radiochemical aspects of generator nuclide parents regularly processed at Los Alamos are introduced. The bulk production of the parent nuclides /sup 68/Ge, /sup 82/Sr, /sup 109/Cd and /sup 88/Zr using charged particle beams is discussed. Production nuclear reactions for these radioisotopes, and chemical separation procedures are presented. Experimental processing yields correspond to 80%-98% of the theoretical thick target yield. Reaction cross sections are modeled using the code ALICE-IPPE; it is observed that the model largely disagrees with experimental values for the nuclear processes treated. Radionuclide production batches are prepared 1-6 times yearly for sales. Batch activities range from 40MBq to 75 GBq.

  15. Medical isotope production: A new research initiative for the Annular Core Research Reactor

    International Nuclear Information System (INIS)

    Coats, R.L.; Parma, E.J.

    1993-01-01

    An investigation has been performed to evaluate the capabilities of the Annular Core Research Reactor and its supporting Hot Cell Facility for the production of 99 Mo and its separation from the fission product stream. Various target irradiation locations for a variety of core configurations were investigated, including the central cavity, fuel and reflector locations, and special target configurations outside the active fuel region. Monte Carlo techniques, in particular MCNP using ENDF B-V cross sections, were employed for the evaluation. The results indicate that the reactor, as currently configured, and with its supporting Hot Cell Facility, would be capable in meeting the current US demand if called upon. Modest modifications, such as increasing the capacity of the external heat exchangers, would permit significantly higher continuous power operation and even greater 99 Mo production ensuring adequate capacity for future years

  16. Computer study of isotope production for medical and industrial applications in high power accelerators

    Science.gov (United States)

    Mashnik, S. G.; Wilson, W. B.; Van Riper, K. A.

    2001-07-01

    Methods for radionuclide production calculation in a high power proton accelerator have been developed and applied to study production of 22 isotopes. These methods are readily applicable both to accelerator and reactor environments and to the production of other radioactive and stable isotopes. We have also developed methods for evaluating cross sections from a wide variety of sources into a single cross section set and have produced an evaluated library covering about a third of all natural elements that may be expanded to other reactions. A 684 page detailed report on this study, with 37 tables and 264 color figures, is available on the Web at http://t2.lanl.gov/publications/.

  17. A computer study of radionuclide production in high power accelerators for medical and industrial applications

    Science.gov (United States)

    Van Riper, K. A.; Mashnik, S. G.; Wilson, W. B.

    2001-05-01

    Methods for radionuclide production calculation in a high power proton accelerator have been developed and applied to study production of 22 isotopes by high-energy protons and neutrons. These methods are readily applicable to accelerator, and reactor, environments other than the particular model we considered and to the production of other radioactive and stable isotopes. We have also developed methods for evaluating cross sections from a wide variety of sources into a single cross section set and have produced an evaluated library covering about a third of all natural elements. These methods also are applicable to an expanded set of reactions. A 684 page detailed report on this study, with 37 tables and 264 color figures is available on the Web at http://t2.lanl.gov/publications/publications.html, or, if not accessible, in hard copy from the authors.

  18. Disability management: corporate medical department management of employee health and productivity.

    Science.gov (United States)

    Burton, W N; Conti, D J

    2000-10-01

    This study describes a proactive in-house program for managing short-term disability (STD) in the workforce of a very large banking system. The goals of this program were to (1) minimize the personal and economic impacts of STD by early intervention, (2) validate the extent and duration of STD, and (3) coordinate medical services and provide guidance to managers that would facilitate an early return to work. This program was made possible by the installation of a comprehensive database, called Occupational Medicine and Nursing Information System. This database mainly includes employees' claims for inpatient and outpatient health services, disability and workers' compensation benefits, wellness program participation, medical examinations and laboratory tests, use of prescription drugs, and results of Health Risk Appraisals. As a result of these efforts, STD event duration declined after this STD management program was implemented in locations heretofore outside the system, and by providing full pay for part-time work after STD, within the system as well. Of note, the average number of STD days per employee showed substantial variation by health plan, including the fact that it was higher (3.9 STD days/employee) for health maintenance organization participants than for indemnity plan members (2.7 STD days/employee).

  19. Sensemaking and the co-production of safety: a qualitative study of primary medical care patients.

    Science.gov (United States)

    Rhodes, Penny; McDonald, Ruth; Campbell, Stephen; Daker-White, Gavin; Sanders, Caroline

    2016-02-01

    This study explores the ways in which patients make sense of 'safety' in the context of primary medical care. Drawing on qualitative interviews with primary care patients, we reveal patients' conceptualisation of safety as fluid, contingent, multi-dimensional, and negotiated. Participant accounts drew attention to a largely invisible and inaccessible (but taken for granted) architecture of safety, the importance of psycho-social as well as physical dimensions and the interactions between them, informal strategies for negotiating safety, and the moral dimension of safety. Participants reported being proactive in taking action to protect themselves from potential harm. The somewhat routinised and predictable nature of the primary medical care consultation, which is very different from 'one off' inpatient spells, meant that patients were not passive recipients of care. Instead they had a stock of accumulated knowledge and experience to inform their actions. In addition to highlighting the differences and similarities between hospital and primary care settings, the study suggests that a broad conceptualisation of patient safety is required, which encompasses the safety concerns of patients in primary care settings. © 2015 The Authors. Sociology of Health & Illness published by John Wiley & Sons Ltd on behalf of Foundation for SHIL.

  20. Risk management in medical product development process using traditional FMEA and fuzzy linguistic approach: a case study

    Science.gov (United States)

    Kirkire, Milind Shrikant; Rane, Santosh B.; Jadhav, Jagdish Rajaram

    2015-12-01

    Medical product development (MPD) process is highly multidisciplinary in nature, which increases the complexity and the associated risks. Managing the risks during MPD process is very crucial. The objective of this research is to explore risks during MPD in a dental product manufacturing company and propose a model for risk mitigation during MPD process to minimize failure events. A case study approach is employed. The existing MPD process is mapped with five phases of the customized phase gate process. The activities during each phase of development and risks associated with each activity are identified and categorized based on the source of occurrence. The risks are analyzed using traditional Failure mode and effect analysis (FMEA) and fuzzy FMEA. The results of two methods when compared show that fuzzy approach avoids the duplication of RPNs and helps more to convert cognition of experts into information to get values of risk factors. The critical, moderate, low level and negligible risks are identified based on criticality; risk treatments and mitigation model are proposed. During initial phases of MPD, the risks are less severe, but as the process progresses the severity of risks goes on increasing. The MPD process should be critically designed and simulated to minimize the number of risk events and their severity. To successfully develop the products/devices within the manufacturing companies, the process risk management is very essential. A systematic approach to manage risks during MPD process will lead to the development of medical products with expected quality and reliability. This is the first research of its kind having focus on MPD process risks and its management. The methodology adopted in this paper will help the developers, managers and researchers to have a competitive edge over the other companies by managing the risks during the development process.

  1. An epidemiological study on herbal product self-medication practice among psychotic outpatients from Serbia: A cross-sectional study

    Directory of Open Access Journals (Sweden)

    Gordana Nikolić

    2018-03-01

    Full Text Available Utilization of herbal products (HPs is a common practice in the traditional medicine of people from southeastern Serbia. In this study, we focused on the usage of HPs as a self-medication practice among patients diagnosed with a mental illness, by aiming to ascertain the usage prevalence, the identity of the main plant taxa utilized, their formulations and target symptoms. This was accomplished through a cross-sectional study of psychiatric outpatients, conducted in the Clinic for Mental Health Protection in Niš, and which included a questionnaire on HP utilization and a non-structured psychiatric interview. Typically, single, middle-aged males, with a secondary education degree, utilized Matricaria chamomilla and/or Melissa officinalis in a form of an infusion (tea for relieving anxiety and psychotic symptoms. In some cases, adverse effects were noted when HPs were used in combination with prescribed psychotropic medications. Our and previous results urge a thorough evaluation of possible benefits and/or harmful interactions of HP with standard medication in the treatment of psychiatric patients.

  2. Economical and technical feasibility study of some radioisotopes production for medical application

    International Nuclear Information System (INIS)

    Souza, A.L.A.B. de.

    1985-01-01

    The economical and technical feasibility study of the production in reactors of some radioisotopes most used in medicine, are presented. The clinical applications of each radioisotope as well as its radioactive concentrations and specific activities are related. Irradiation procedures based in the foregoing data are given. Part of the study is dedicated to quality control. (M.A.C.) [pt

  3. 77 FR 74196 - Draft Guidance for Industry on Safety Considerations for Product Design To Minimize Medication...

    Science.gov (United States)

    2012-12-13

    ... error-prone label and packaging designs. Among these measures, FDA agreed that by the end of FY 2010... minimizing risks with the design of drug product container labels, carton labeling, and packaging... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2012-D-1005...

  4. 77 FR 11134 - Guidance for Industry on Postmarketing Adverse Event Reporting for Medical Products and Dietary...

    Science.gov (United States)

    2012-02-24

    ... and Drug Administration, 5100 Paint Branch Pkwy., College Park, MD 20740, 301-436-1488. SUPPLEMENTARY... authorization for products authorized for emergency use under section 564 of the Federal Food, Drug, and... DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration [Docket No. FDA-2008-D-0610...

  5. Antimicrobial Consumption in Medicated Feeds in Vietnamese Pig and Poultry Production.

    Science.gov (United States)

    Van Cuong, Nguyen; Nhung, Nguyen Thi; Nghia, Nguyen Huu; Mai Hoa, Nguyen Thi; Trung, Nguyen Vinh; Thwaites, Guy; Carrique-Mas, Juan

    2016-09-01

    Antimicrobials are extensively used as growth promoters in animal feeds worldwide, but reliable estimates are lacking. We conducted an internet-based survey of commercial chicken and pig feed products officially approved for sale in Vietnam over the period March-June 2015. Information on the antimicrobial contents in feed products, alongside animal production data, was used to estimate in-feed antimicrobial consumption to produce one kilogram of live animal (chicken, pig), as well as to estimate country-wide antimicrobial consumption through animal feeds. A total of 1462 commercial feed formulations were examined. The survey-adjusted estimated antimicrobial contents were 25.7 and 62.3 mg/kg in chicken and pig feeds, respectively. Overall, it was estimated that 77.4 mg [95% CI 48.1-106.8] and 286.6 mg [95% CI 191.6-418.3] of in-feed antimicrobials were used to raise 1 kg of live chicken and pig, respectively. Bacitracin (15.5% feeds), chlortetracycline (11.4%), and enramycin (10.8%) were the most common antimicrobials present in chicken feed formulations, whereas bacitracin (24.8%), chlortetracycline (23.9%), and florfenicol (17.4%) were the most common in pig feed formulations. Overall, 57% of the total quantitative usage consisted of antimicrobials regarded by WHO of importance for human medicine, including amoxicillin, colistin, tetracyclines, neomycin, lincomycin, and bacitracin. These figures confirm a very high magnitude of in-feed consumption of antimicrobials, especially in pig production. Results from this study should encourage further monitoring of antimicrobials used in animal production, and foster discussion about existing policies on inclusion of antimicrobials in animal feed rations.

  6. The effect of hormone therapy on women's quality of life in the first year of the Estonian Postmenopausal Hormone Therapy trial

    OpenAIRE

    Veerus, Piret; Hovi, Sirpa-Liisa; Sévon, Tiina; Hunter, Myra; Hemminki, Elina

    2012-01-01

    Background For postmenopausal women, the main reason to start hormone therapy (HT) is to reduce menopausal symptoms and to improve quality of life (QOL). The aim of this study was to analyse the impact of HT on different aspects of symptom experience and QOL during a randomised trial. A total of 1823 postmenopausal women were recruited into the Estonian Postmenopausal Hormone Therapy (EPHT) trial in 1999–2001. Women were randomised to blind HT, open-label HT, placebo or non-treatment ...

  7. THE CHOICES BETWEEN FAIR VALUE AND HISTORICAL COST ACCOUNTING FOR NON-CURRENT REAL ASSETS AT LATVIAN, LITHUANIAN AND ESTONIAN LISTED COMPANIES DURING THE REPORTING YEAR OF 2011

    OpenAIRE

    Justine Jaunzeme

    2013-01-01

    Stock investors require financial statements of listed companies for their investment decision-making. J. Gassen and K. Schwedler (2008) have empirically proved that EU investors who use financial statements prefer reported assets’ fair values over historical costs. The purpose of this study is to test whether the Latvian, Lithuanian and Estonian listed companies set accounting policies for their non-current real assets in favor of EU investors who prefer fair values over historical costs. Th...

  8. Feasibility studies on the potential of employing electron beam machine for non-medical products irradiation in Malaysia

    International Nuclear Information System (INIS)

    Siti Aiasah Hashim; Sarada Idris

    2012-01-01

    In Malaysia, two 10 MeV irradiators were installed by private companies as part of in-house manufacturing or as third party sterilization service provider. At the same time, the 3 MeV EPS 3000 machine at Nuclear Malaysia is providing irradiation services for various purposes and products. With the current increase in demand in automotive manufacturing for better quality harnesses and components, the irradiation service at Nuclear Malaysia had to provide extended time to cope with the requests. This paper looks at the potential of setting up a commercial irradiation facility to cater for non-medical products such as automotive wires and tubing, food, fruits, cosmetic and semiconductors. Intensive interviews with related industries were carried out throughout Malaysia to evaluate the potential of installing electron beam machine for commercial irradiation. The results show that a majority of non-medical industries are not aware of the irradiation service provided by Nuclear Malaysia, although many understand the need for it. A multipurpose irradiator is desired in order to optimize the usage since a single dedicated machine may be too costly to sustain. (author)

  9. Future perspective of medical radionuclide production and related educational problems in developing countries

    International Nuclear Information System (INIS)

    Uenak, Turan

    1999-01-01

    The radionuclide applications are continuously escalation in nuclear medicine. Especially, the development of positron emission tomography (PET) technique has increased very rapidly the use of short-lived radioisotopes in this field, and this has caused the development of compact medical cyclotrons. About 30 cyclotrons operated in the world wide are actually found in the developing countries. In parallel of this progress, the basic nuclear sciences, especially nuclear chemistry and radiopharmaceutical chemistry will probably very important fields in the next new century for nuclear science and technology applications in health care sector. For this reason, the developing countries should eventually revise their academic educational and training programs aiming to ensure the formation of qualified basic nuclear scientists such as nuclear chemist, nuclear physicist, radiopharmacist, etc. (author)

  10. Production of medically useful bromine isotopes via alpha-particle induced nuclear reactions

    Science.gov (United States)

    Breunig, Katharina; Scholten, Bernhard; Spahn, Ingo; Hermanne, Alex; Spellerberg, Stefan; Coenen, Heinz H.; Neumaier, Bernd

    2017-09-01

    The cross sections of α-particle induced reactions on arsenic leading to the formation of 76,77,78Br were measured from their respective thresholds up to 37 MeV. Thin sediments of elemental arsenic powder were irradiated together with Al degrader and Cu monitor foils using the established stacked-foil technique. For determination of the effective α-particle energies and of the effective beam current through the stacks the cross-section ratios of the monitor nuclides 67Ga/66Ga were used. This should help resolve discrepancies in existing literature data. Comparison of the data with the available excitation functions shows some slight energy shifts as well as some differences in curve shapes. The calculated thick target yields indicate, that 77Br can be produced in the energy range Eα = 25 → 17 MeV free of isotopic impurities in quantities sufficient for medical application.

  11. Annual Medical Expenditure and Productivity Loss Among Colorectal, Female Breast, and Prostate Cancer Survivors in the United States.

    Science.gov (United States)

    Zheng, Zhiyuan; Yabroff, K Robin; Guy, Gery P; Han, Xuesong; Li, Chunyu; Banegas, Matthew P; Ekwueme, Donatus U; Jemal, Ahmedin

    2016-05-01

    There are limited nationally representative estimates of the annual economic burden among survivors of the three most prevalent cancers (colorectal, female breast, and prostate) in both nonelderly and elderly populations in the United States. The 2008 to 2012 Medical Expenditure Panel Survey data were used to identify colorectal (n = 540), female breast (n = 1568), and prostate (n = 1170) cancer survivors and individuals without a cancer history (n = 109 423). Excess economic burden attributable to cancer included per-person excess annual medical expenditures and productivity losses (employment disability, missed work days, and days stayed in bed). All analyses were stratified by cancer site and age (nonelderly: 18-64 years vs elderly: ≥ 65 years). Multivariable analyses controlled for age, sex, race/ethnicity, marital status, education, number of comorbidities, and geographic region. All statistical tests were two-sided. Compared with individuals without a cancer history, cancer survivors experienced annual excess medical expenditures (for the nonelderly population, colorectal: $8647, 95% confidence interval [CI] = $4932 to $13 974, P breast: $5119, 95% CI = $3439 to $7158, P breast: $2288, 95% CI = $814 to $3995, P = .002; prostate: $3524, 95% CI = $1539 to $5909, P breast cancer survivors experienced statistically significant annual excess employment disability (13.6%, P cancer sites had comparable productivity losses as those without a cancer history. Colorectal, breast, and prostate cancer survivors experienced statistically significantly higher economic burden compared with individuals without a cancer history; however, excess economic burden varies by cancer site and age. Targeted efforts will be important in reducing the economic burden of colorectal, breast, and prostate cancer. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  12. Radiopharmaceuticals in positron emission tomography: Radioisotope productions and radiolabelling procedures at the Austin and Repatriation Medical Centre

    Energy Technology Data Exchange (ETDEWEB)

    Tochon-Danguy, H.J.; Sachinidis, J.I.; Chan, J.G.; Cook, M. [Austin and Repatriation Medical Centre, Melbourne, VIC (Australia). Centre for Positron Emission Tomography

    1997-10-01

    Positron Emission Tomography (PET) is a technique that utilizes positron-emitting radiopharmaceuticals to map the physiology, biochemistry and pharmacology of the human body. Positron-emitting radioisotopes produced in a medical cyclotron are incorporated into compounds that are biologically active in the body. A scanner measures radioactivity emitted from a patient`s body and provides cross-sectional images of the distribution of these radiolabelled compounds in the body. It is the purpose of this paper to review the variety of PET radiopharmaceuticals currently produced at the Austin and Repatriation Medical Centre in Melbourne. Radioisotope production, radiolabelling of molecules and quality control of radiopharmaceuticals will be discussed. A few examples of their clinical applications will be shown as well. During the last five years we achieved a reliable routine production of various radiopharmaceuticals labelled with the four most important positron-emitters: oxygen-15 (t,{sub 1/2}=2min), nitrogen-13 (t{sub 1/2}= 10 min), carbon-11 (t{sub 1/2}=20 min) and fluorine-18 (t{sub 1/2}= 110 min). These radiopharmaceuticals include [{sup 15}O]oxygen, [{sup 15}O]carbon monoxide, [{sup 15}O]carbon dioxide, [{sup 15}O]water, [{sup 13}N]ammonia, [{sup 11}C]flumazenil, [{sup 11}C]SCH23390, [{sup 18}F]fluoromisonidazole and [{sup 18}F]fluoro-deoxy-glucose ([{sup 18}F]FDG). In addition, since the half life of [{sup 18}F] is almost two hours, regional distribution can be done, and the Austin and Repatriation Medical Centre is currently supplying [{sup 18}F]FDG in routine to other hospitals. Future new radiopharmaceuticals development include a [{sup 18}F]thymidine analog to measure cell proliferation and a [{sup 11}C]pyrroloisoquinoline to visualize serotonergic neuron abnormalities. (authors) 23 refs., 2 tabs.

  13. Radiopharmaceuticals in positron emission tomography: Radioisotope productions and radiolabelling procedures at the Austin and Repatriation Medical Centre

    International Nuclear Information System (INIS)

    Tochon-Danguy, H.J.; Sachinidis, J.I.; Chan, J.G.; Cook, M.

    1997-01-01

    Positron Emission Tomography (PET) is a technique that utilizes positron-emitting radiopharmaceuticals to map the physiology, biochemistry and pharmacology of the human body. Positron-emitting radioisotopes produced in a medical cyclotron are incorporated into compounds that are biologically active in the body. A scanner measures radioactivity emitted from a patient's body and provides cross-sectional images of the distribution of these radiolabelled compounds in the body. It is the purpose of this paper to review the variety of PET radiopharmaceuticals currently produced at the Austin and Repatriation Medical Centre in Melbourne. Radioisotope production, radiolabelling of molecules and quality control of radiopharmaceuticals will be discussed. A few examples of their clinical applications will be shown as well. During the last five years we achieved a reliable routine production of various radiopharmaceuticals labelled with the four most important positron-emitters: oxygen-15 (t, 1/2 =2min), nitrogen-13 (t 1/2 = 10 min), carbon-11 (t 1/2 =20 min) and fluorine-18 (t 1/2 = 110 min). These radiopharmaceuticals include [ 15 O]oxygen, [ 15 O]carbon monoxide, [ 15 O]carbon dioxide, [ 15 O]water, [ 13 N]ammonia, [ 11 C]flumazenil, [ 11 C]SCH23390, [ 18 F]fluoromisonidazole and [ 18 F]fluoro-deoxy-glucose ([ 18 F]FDG). In addition, since the half life of [ 18 F] is almost two hours, regional distribution can be done, and the Austin and Repatriation Medical Centre is currently supplying [ 18 F]FDG in routine to other hospitals. Future new radiopharmaceuticals development include a [ 18 F]thymidine analog to measure cell proliferation and a [ 11 C]pyrroloisoquinoline to visualize serotonergic neuron abnormalities. (authors)

  14. Developing a dashboard for benchmarking the productivity of a medication therapy management program.

    Science.gov (United States)

    Umbreit, Audrey; Holm, Emily; Gander, Kelsey; Davis, Kelsie; Dittrich, Kristina; Jandl, Vanda; Odell, Laura; Sweeten, Perry

    To describe a method for internal benchmarking of medication therapy management (MTM) pharmacist activities. Multisite MTM pharmacist practices within an integrated health care system. MTM pharmacists are located within primary care clinics and provide medication management through collaborative practice. MTM pharmacist activity is grouped into 3 categories: direct patient care, nonvisit patient care, and professional activities. MTM pharmacist activities were tracked with the use of the computer-based application Pharmacist Ambulatory Resource Management System (PhARMS) over a 12-month period to measure growth during a time of expansion. A total of 81% of MTM pharmacist time was recorded. A total of 1655.1 hours (41%) was nonvisit patient care, 1185.2 hours (29%) was direct patient care, and 1190.4 hours (30%) was professional activities. The number of patient visits per month increased during the study period. There were 1496 direct patient care encounters documented. Of those, 1051 (70.2%) were face-to-face visits, 257 (17.2%) were by telephone, and 188 (12.6%) were chart reviews. Nonvisit patient care and professional activities also increased during the period. PhARMS reported MTM pharmacist activities and captured nonvisit patient care work not tracked elsewhere. Internal benchmarking data proved to be useful for justifying increases in MTM pharmacist personnel resources. Reviewing data helped to identify best practices from high-performing sites. Limitations include potential for self-reporting bias and lack of patient outcomes data. Implementing PhARMS facilitated internal benchmarking of patient care and nonpatient care activities in a regional MTM program. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  15. Non-market value of Estonian seminatural grasslands: a contingent valuation study. Eesti poolloodusliku rohumaa turuväline väärtus: tingliku hindamise uuring

    Directory of Open Access Journals (Sweden)

    Helli Lepasaar

    2015-12-01

    Full Text Available Seminatural grasslands i.e. the floodplain meadows, seashore meadows, wooded meadows, dry meadows, wooded pastures are the very traditional part of Estonian landscapes, which play an important role in the appearance of the landscape in general and also serve as an important habitat for many plant and animal species. In order to preserve the seminatural grasslands continuous annual mowing and/or pasturing is needed. This activity is not economically profitable and needs subsidizing. The authors of the work raise a hypothesis that the Estonian seminatural grasslands could be viewed as a valuable non-market environmental good for which a significant public demand exists. In order to find out the non-market value of the seminatural grasslands a contingent valuation study was carried out among the Estonian working-age population (size of the sample 1061 individuals. The average individual willingness to pay was 11.3 euros. During the study, the authors constructed the total demand function and discovered that the total annual demand for seminatural grasslands was 17.9 million euros.

  16. Towards more reliable automated multi-dose dispensing: retrospective follow-up study on medication dose errors and product defects.

    Science.gov (United States)

    Palttala, Iida; Heinämäki, Jyrki; Honkanen, Outi; Suominen, Risto; Antikainen, Osmo; Hirvonen, Jouni; Yliruusi, Jouko

    2013-03-01

    To date, little is known on applicability of different types of pharmaceutical dosage forms in an automated high-speed multi-dose dispensing process. The purpose of the present study was to identify and further investigate various process-induced and/or product-related limitations associated with multi-dose dispensing process. The rates of product defects and dose dispensing errors in automated multi-dose dispensing were retrospectively investigated during a 6-months follow-up period. The study was based on the analysis of process data of totally nine automated high-speed multi-dose dispensing systems. Special attention was paid to the dependence of multi-dose dispensing errors/product defects and pharmaceutical tablet properties (such as shape, dimensions, weight, scored lines, coatings, etc.) to profile the most suitable forms of tablets for automated dose dispensing systems. The relationship between the risk of errors in dose dispensing and tablet characteristics were visualized by creating a principal component analysis (PCA) model for the outcome of dispensed tablets. The two most common process-induced failures identified in the multi-dose dispensing are predisposal of tablet defects and unexpected product transitions in the medication cassette (dose dispensing error). The tablet defects are product-dependent failures, while the tablet transitions are dependent on automated multi-dose dispensing systems used. The occurrence of tablet defects is approximately twice as common as tablet transitions. Optimal tablet preparation for the high-speed multi-dose dispensing would be a round-shaped, relatively small/middle-sized, film-coated tablet without any scored line. Commercial tablet products can be profiled and classified based on their suitability to a high-speed multi-dose dispensing process.

  17. University of Texas Southwestern Medical Center: U01 Natural Products Screening | Office of Cancer Genomics

    Science.gov (United States)

    The goal of this project was to enlarge the chemical space probed by Project 1 (High-Throughput siRNA Screening of a Non-Small Cell Lung Cancer Cell Line Panel) by screening an expanded natural products library (~40,000) in an effort to further define vulnerabilities and therapeutic targets in non-small cell lung cancer. This new library is derived from a diverse collection of marine bacteria (prepared by Dr. John MacMillan, University of Texas Southwestern).

  18. Potential medical applications of the plasma focus in the radioisotope production for PET imaging

    Science.gov (United States)

    Roshan, M. V.; Razaghi, S.; Asghari, F.; Rawat, R. S.; Springham, S. V.; Lee, P.; Lee, S.; Tan, T. L.

    2014-06-01

    Devices other than the accelerators are desired to be investigated for generating high energy particles to induce nuclear reaction and positron emission tomography (PET) producing radioisotopes. The experimental data of plasma focus devices (PF) are studied and the activity scaling law for External Solid Target (EST) activation is established. Based on the scaling law and the techniques to enhance the radioisotopes production, the feasibility of generating the required activity for PET imaging is studied.

  19. A compact and high current FFAG for the production of radioisotopes for medical application

    CERN Document Server

    Bruton, David; Edgecock, Rob; Seviour, Rebecca; Johnstone, Carol

    2017-01-01

    A low energy Fixed Field Alternating Gradient(FFAG)accelerator has been designed for the production of radioisotopes. Tracking studies have been conducted using the OPAL code, including the effects of space charge. Radioisotopes have a wide range of uses in medicine, and recent disruption to the supply chain has seen a renewed effort to find alternative isotopes and production methods. The design features separate sector magnets with non-scaling, non-linear field gradients but without the counter bends commonly found in FFAG’s. The machine is isochronous at the level of 0.3% up to at least 28MeV and hence able to operate in Continuous Wave (CW) mode. Both protons and helium ions can be used with this design and it has been demonstrated that proton beams with currents of up to 20 mA can be accelerated. An interesting option for the production of radioisotopes is the use of a thin internal target. We have shown that this design has large acceptance, ideal for allowing the beam to be recirculated through t...

  20. Improving Papanicolaou test quality and reducing medical errors by using Toyota production system methods.

    Science.gov (United States)

    Raab, Stephen S; Andrew-Jaja, Carey; Condel, Jennifer L; Dabbs, David J

    2006-01-01

    The objective of the study was to determine whether the Toyota production system process improves Papanicolaou test quality and patient safety. An 8-month nonconcurrent cohort study that included 464 case and 639 control women who had a Papanicolaou test was performed. Office workflow was redesigned using Toyota production system methods by introducing a 1-by-1 continuous flow process. We measured the frequency of Papanicolaou tests without a transformation zone component, follow-up and Bethesda System diagnostic frequency of atypical squamous cells of undetermined significance, and diagnostic error frequency. After the intervention, the percentage of Papanicolaou tests lacking a transformation zone component decreased from 9.9% to 4.7% (P = .001). The percentage of Papanicolaou tests with a diagnosis of atypical squamous cells of undetermined significance decreased from 7.8% to 3.9% (P = .007). The frequency of error per correlating cytologic-histologic specimen pair decreased from 9.52% to 7.84%. The introduction of the Toyota production system process resulted in improved Papanicolaou test quality.

  1. The FDA may not regulate tobacco products as "drugs" or as "medical devices".

    Science.gov (United States)

    Merrill, R A

    1998-04-01

    Professor Richard Merrill contends that the Federal Food, Drug, and Cosmetic Act does not grant the FDA regulatory authority over cigarettes and smokeless tobacco products. The fact that Congress did not expressly deny the FDA regulatory authority over tobacco cannot, Professor Merrill argues, be used to infer such authority. This inference is particularly inappropriate in the case of tobacco regulation, he maintains, because there is compelling evidence that Congress had no intention of delegating this authority to the FDA. He is unpersuaded that presidential approval legally sanctions the FDA's claim of authority by granting it a superficial political legitimacy. Finally, he reminds us of the FDA's own repeated denials of jurisdiction over tobacco products, and he recalls the numerous times that Congress passed legislation directed at tobacco without granting the FDA any role in its regulation. Professor Merrill's Essay, like the other pieces in this volume, was written after the United States District Court for the Middle District of North Carolina decided Coyne Beahm v. FDA, but before a three judge panel of the United States Court of Appeals for the Fourth Circuit reversed that decision in Brown & Williamson Tobacco Corp. v. FDA. In Coyne Beahm, the District Court held that the Federal Food, Drug, and Cosmetic Act authorized the FDA to regulate tobacco products, but not tobacco advertising. The Fourth Circuit rejected the District Court's jurisdictional ruling and invalidated the FDA's regulations in their entirety. The Clinton Administration has since requested an en banc rehearing before the Fourth Circuit.

  2. Reporting bias inflates the reputation of medical treatments: A comparison of outcomes in clinical trials and online product reviews.

    Science.gov (United States)

    de Barra, Mícheál

    2017-03-01

    People often hold unduly positive expectations about the outcomes of medicines and other healthcare products. Here the following explanation is tested: people who have a positive outcome tend to tell more people about their disease/treatment than people with poor or average outcomes. Akin to the file drawer problem in science, this systematically and positively distorts the information available to others. If people with good treatment outcomes are more inclined to tell others, then they should also be more inclined to write online medical product reviews. Therefore, average treatment outcomes in these reviews should be more positive than those found in randomised controlled trials (RCTs). Data on duration of treatment and outcome (i.e., weight/cholesterol change) were extracted from user-generated health product reviews on Amazon.com and compared to RCT data for the same treatments using ANOVA. The sample included 1675 reviews of cholesterol reduction (Benecol, CholestOff) and weight loss (Orlistat) treatments and the primary outcome was cholesterol change (Bencol and CholestOff) or weight change (Orlistat). In three independent tests, average outcomes reported in the reviews were substantially more positive than the outcomes reported in the medical literature (η 2  = 0.01 to 0.06; p = 0.04 to 0.001). For example, average cholesterol change following use of Benecol is -14 mg/dl in RCTs and -45 mg/dl in online reviews. People with good treatment outcomes are more inclined to share information about their treatment, which distorts the information available to others. People who rely on word of mouth reputation, electronic or real life, are likely to develop unduly positive expectations. Crown Copyright © 2017. Published by Elsevier Ltd. All rights reserved.

  3. Production of Astatine-211 at the Duke University Medical Center for its regional distribution

    Energy Technology Data Exchange (ETDEWEB)

    Zalutsky, Michael [Duke University Medical Center, Durham, NC (United States)

    2016-01-01

    Systemic targeted radiation therapy and radioimmunotherapy continue to be important tools in the treatment of certain cancers. Because of their high energy and short path length, alpha particle emitters such as 211At are more effective than either external beam x- ray or in vivo beta radiation in delivering potentially curative doses of radiation. The limited clinical trials that have been conducted to date have yielded encouraging responses in some patients, e.g., malignant brain tumors. In order to escalate the additional necessary research and development in radiochemistry, radiobiology and efficacy evaluation of alpha particle radiotherapeutics, it is universally agreed that access to an affordable, reliable supply of 211At is warranted. In conjunction with the Department of Energy's intent to enhance stable and radioactive isotope availability for research applications, it is the primary objective of this project to improve 211At production and purification capabilities at Duke so that this radionuclide can be supplied to researchers at other institutions throughout the US.The most widely used 211At production method involves the α,2n reaction on Bismuth using a cyclotron with beams ≤ 28 MeV. Yields can be enhanced with use of an internal target that allows for a higher alpha fluence plus efficient heat dissipation in the target. Both of these items are in place at Duke; however, in order to support production for multi-institutional use, irradiation campaigns in excess of 50 µAp and four hours duration will be needed. Further, post-irradiation processing equipment is lacking that will enable the distribution process. Financial support is sought for i) a shielded, ventilated processing/containment hood; ii) development of a post-irradiation target retrieval system; iii) fabrication of a 211At distillation and recovery module and iv) a performance review and, where needed, an enhancement of seven

  4. Vegetable, Sauce, and Bakery Item Production Guides Prepared for Walter Reed Army Medical Center

    Science.gov (United States)

    1981-01-01

    minutes. 113 82 2. Combine with the above and brown. Meat stock 12.55 5,698 Modified starch (Col-Flo 67 or equivalent) 0.1+5 20** Caramel color...0.03 ll* 3. Combine meat stock, modified starch and caramel color. Add to above and stir well. Keat to l85°F (85°C). h. Pour h lb 12 oz...Products Flour, Hard Wheat: NSN 8920-00-165-6863 Fed N-F-OOU81, Type I, Class B, Style 2 Special Procurements 1. Starch, Col-Flo 6j 2, Caramel

  5. The aging of radiosterilized and modified products and materials intended for medical use

    International Nuclear Information System (INIS)

    Imrishova, D.

    1976-01-01

    The aging of radiosterilized sanitary products and materials during storage is of importance from a practical viewpoint. During storage, some materials alter their physicochemical and mechanical properties which may affect their applicability. Under conditions of modified aging, changes in physicochemical structure of untreated cotton canvas treated chemically and mechanically to increase its moisture absorbing capacity were studied. An analysis of samples irradiated with doses of 2.5-10 Mrads has confirmed that ionizing radiation impairs some macromolecular bonds in cellulose materials thus affecting their degradation during storage. Under such conditions, the progressive degradation of cellulose materials is characterized by increased oxidation as demonstrated by infrared spectral analysis. (author)

  6. Chemistry for commercial scale production of yttrium-90 for medical research

    International Nuclear Information System (INIS)

    Wike, J.S.; Guyer, C.E.; Ramey, D.W.; Phillips, B.P.

    1990-01-01

    Studies were initiated at Oak Ridge National Laboratory (ORNL) in 1982 for the radiolabeling of resin microspheres with yttrium-90 ( 90 Y) for liver cancer therapy. Yttrium-90 is the decay product of strontium-90 ( 90 Sr). Subsequently, 90 Y became a major radioisotope of choice for labeling antibodies for therapeutic trials in the treatment of other forms of cancer. A 25-Ci 90 Y generator or 90 Sr cow was placed in service to supply the anticipated needs of customers. In vivo use of 90 Y required that the 90 Sr contamination levels be kept below 10 μCi/Ci 90 Y (corrected to preparation time). Also, it was necessary to remove trace metals that interfered in the 90 Y antibody radiolabeling process, giving low radiolabeling yields. Di-(2-ethylhexyl) phosphoric acid (HDEHP) in dodecane has been used routinely at ORNL to extract 90 Y and thereby give a product that meets the radiochemical purity required with respect to 90 Sr. Methods were also developed to remove interfering trace elements to provide acceptable labeling yields. (author)

  7. Development of an accelerator driven neutron activator for medical radioisotope production

    Energy Technology Data Exchange (ETDEWEB)

    Abbas, Kamel [Via Fermi 2749, I-21020 Ispra (Italy)], E-mail: kamel.abbas@jrc.it; Buono, Stefano; Burgio, Nunzio; Cotogno, Giulio; Gibson, Neil; Maciocco, Luca; Mercurio, Giovanni; Santagata, Alfonso; Simonelli, Federica; Tagziria, Hamid [Via Fermi 2749, I-21020 Ispra (Italy)

    2009-04-01

    A compact, accelerator driven, neutron activator based on a modified version of the Adiabatic Resonance Crossing (ARC) concept has been developed, with the aim of efficiently utilising ion-beam generated neutrons for the production of radioactive nanoparticles for brachytherapy. Extensive Monte Carlo simulations have been carried out to optimise the design of the activator, which is based on a hybrid approach, coupling a lead buffer and a graphite reflector. Computational Fluid Dynamic methods have been used for the thermal-hydraulic design of the neutron-generating beryllium target to ensure efficient water cooling under high proton beam currents. The facility has been tested under various experimental configurations, and the activation yields of different materials, measured with {gamma}-spectrometry techniques, have been compared with theoretical predictions. In this paper the main elements of the activator are described, and calculated and measured results for pure Au, Mo, Ho, and Re foils as well as for Re and Ho nanoparticle samples are presented. A satisfactory agreement between experiment and theory was found, confirming that the improved ARC activator developed in this work is suitable for isotope production for certain applications such as brachytherapy.

  8. High Power Molten Targets for Radioactive Ion Beam Production: from Particle Physics to Medical Applications

    CERN Document Server

    De Melo Mendonca, T M

    2014-01-01

    Megawatt-class molten targets, combining high material densities and good heat transfer properties are being considered for neutron spallation sources, neutrino physics facilities and radioactive ion beam production. For this last category of facilities, in order to cope with the limitation of long diffusion times affecting the extraction of short-lived isotopes, a lead-bismuth eutectic (LBE) target loop equipped with a diffusion chamber has been proposed and tested offline during the EURISOL design study. To validate the concept, a molten LBE loop is now in the design phase and will be prototyped and tested on-line at CERN-ISOLDE. This concept was further extended to an alternative route to produce 1013 18Ne/s for the Beta Beams, where a molten salt loop would be irradiated with 7 mA, 160 MeV proton beam. Some elements of the concept have been tested by using a molten fluoride salt static unit at CERNISOLDE. The investigation of the release and production of neon isotopes allowed the measurement of the diffu...

  9. REQUIREMENTS FOR STORAGE AND TRANSPORT OF BIOTECHNOLOGICAL MEDICAL PRODUCTS IN ACCORDANCE WITH THE REGULATORY FRAMEWORK OF MINISTRY OF PUBLIC HEALTH OF UKRAINE AND DETECTION OF VIOLATIONS IN THE MEDICAL AND PHARMACEUTICAL INSTITUTIONS

    Directory of Open Access Journals (Sweden)

    Shukaeva O.

    2015-05-01

    Full Text Available Introduction. The rapid development of the pharmaceutical industry and the expansion of the range of biotech drugs require special conditions to ensure the quality, storage and transport through out the entire chain: manufacturer - distributor - pharmacy - hospital - the patient.We analyzed the current legislative frame work of Ministry of Public Health of Ukraine and conducted a study to identify and analyze of typical violations in the medical and pharmaceutical institutions. The aim of the investigation was to investigate and analyze inspection acts under storage and transport of biological medical products and identify major violations during the performance requirements for storage and transportation of drugs, level of awareness about medical products which are requiring special storage requirement. Methods: systemic, logistical, structural, marketing, regulatory. Results & discussion. According to the data presented in the report «Assessing biosimilar uptake and competition in European markets» of «IMS Health», sales of medical products with biological nature - biological medicinal products and biosymilyars is about 27% of total sales of drugs in the EU. This segment of the pharmaceutical market is characterized by faster growth compared to the pharmaceutical marketas a whole. Thus, in 2012-2013 years sales of biological medical products in the EU countries increased by 5.5% compared to 1.5% increase in total sales of drugs. It is important that in Europe, according to the 2013 preparations, the market share in value terms, with eight to prepare biological products, the term of patent protection that are either already expired or will expireby 2020, and therefore they can be competitors with biosymilars. In creasing the number of medications on the market requires a careful approach of storing and preserving the quality of distribution during throughout the life of the medical products in the chain: manufacturer - distributor

  10. Measurements of activation products associated with Havar foils from a GE PETtrace medical cyclotron using high resolution gamma spectroscopy.

    Science.gov (United States)

    Manickam, Vivek; Brey, Richard R; Jenkins, Peter A; Christian, Paul E

    2009-02-01

    Havar foils are specially engineered for beam-line windows used in the General Electric (GE) PETtrace medical cyclotron that can withstand the high pressure differentials and also temperatures developed near the target with proton bombardment. These foils effectively separate components along the beam line of the cyclotron. Various activation products are produced in the foils from the primary proton beam and other secondary radiations. An accurate estimate of the activation products is necessary for the disposal of these foils. The foils were assayed using two High Purity Germanium (HPGe) detectors calibrated over a wide energy range. These were positioned at different distances (0.10 m, 0.24 m, and 1.74 m) away from the detector faces to accommodate their high activities. A summary of the anticipated relative abundance of each activation product and a scatter plot of the average exposure rate per unit charge incident on the foil vs. time post-activation are provided. A detailed spectral analysis of the foils in the energy ranges between 12 keV to 300 keV and 12 keV through 2,500 keV revealed the residual activation products 56Co, 57Co, 58Co, 54Mn, and 183Re at 264 d post-irradiation. Spectral examinations of the different foils removed between 2003 and 2005 show the same activation products regardless of the irradiation time or foil position in the target assembly. The information presented in this paper can be used along with the integrated charge incident on the foils in estimating the activity of Havar foils for the purpose of disposal.

  11. Validation of a standard field test method in four countries to assess the toxicity of residues in dung of cattle treated with veterinary medical products

    NARCIS (Netherlands)

    Floate, Kevin D.; Düring, Rolf Alexander; Hanafi, Jamal; Jud, Priska; Lahr, Joost; Lumaret, Jean Pierre; Scheffczyk, Adam; Tixier, Thomas; Wohde, Manuel; Römbke, Jörg; Sautot, Lucille; Blanckenhorn, Wolf U.

    2016-01-01

    Registration of veterinary medical products includes the provision that field tests may be required to assess potential nontarget effects associated with the excretion of product residues in dung of treated livestock (phase II, tier B testing). However, regulatory agencies provide no guidance on

  12. A novel approach to the production of medical radioisotopes: the homogeneous SLOWPOKE reactor

    International Nuclear Information System (INIS)

    Bonin, H.W.; Hilborn, J.W.; Carlin, G.E.; Gagnon, R.; Busatta, P.

    2015-01-01

    In 2009, the unexpected 15-month outage of the Canadian NRU nuclear reactor resulted in a sudden 30% world shortage, with higher shortages experienced in North America than in Europe. Commercial radioisotope production is from just eight nuclear reactors, most being aging systems near the end of their service life. This paper proposes a more efficient production and distribution model. Tc-99m unit doses would be distributed to regional hospitals from ten integrated 'industrial radiopharmacies', located at existing licensed nuclear reactor sites in North America. At each site, one or more 20 kW Homogeneous SLOWPOKE nuclear reactors would deliver 15 litres of irradiated aqueous uranyl sulfate fuel solution daily to industrial-scale hot cells, for extraction of Mo-99; and the low-enriched uranium would be recycled. Purified Mo-99 would be incorporated in large Mo-99/Tc-99m generators for extraction of Tc-99m five days a week; and each automated hot-cell facility would be designed to load up to 7,000 Tc-99m syringes daily for road delivery to all of the nuclear medicine hospitals within a 3-hour range. At the current price of $20 per unit dose, the annual gross income from 10 sites would be approximately $360 million. The Homogeneous SLOWPOKE reactor evolved from the inherently safe SLOWPOKE-2 research reactor, with a double goal: replacing the heterogeneous SLOWPOKE-2 reactors at the end-of-core life, enabling them to continue their primary missions of research and education, together with full time commercial radioisotope production. The Homogeneous SLOWPOKE reactor was modelled using both deterministic and probabilistic reactor simulation codes. The homogeneous fuel mixture is a dilute aqueous solution of low-enriched uranyl sulfate containing approximately 1 kg of U-235. The reactor is controlled by mechanical absorber rods in the beryllium reflector. Safety analysis was carried out for both normal operation and transient conditions. The most severe

  13. A novel approach to the production of medical radioisotopes: the homogeneous SLOWPOKE reactor

    Energy Technology Data Exchange (ETDEWEB)

    Bonin, H.W., E-mail: bonin-h@rmc.ca [Royal Military College of Canada, Kingston, Ontario (Canada); Hilborn, J.W. [retired, Atomic Energy of Canada Limited, Chalk River, Ontario (Canada); Carlin, G.E. [Ontario Power Generation, Toronto, Ontario (Canada); Gagnon, R.; Busatta, P. [Royal Canadian Navy, Ottawa, Ontario (Canada)

    2015-03-15

    In 2009, the unexpected 15-month outage of the Canadian NRU nuclear reactor resulted in a sudden 30% world shortage, with higher shortages experienced in North America than in Europe. Commercial radioisotope production is from just eight nuclear reactors, most being aging systems near the end of their service life. This paper proposes a more efficient production and distribution model. Tc-99m unit doses would be distributed to regional hospitals from ten integrated 'industrial radiopharmacies', located at existing licensed nuclear reactor sites in North America. At each site, one or more 20 kW Homogeneous SLOWPOKE nuclear reactors would deliver 15 litres of irradiated aqueous uranyl sulfate fuel solution daily to industrial-scale hot cells, for extraction of Mo-99; and the low-enriched uranium would be recycled. Purified Mo-99 would be incorporated in large Mo-99/Tc-99m generators for extraction of Tc-99m five days a week; and each automated hot-cell facility would be designed to load up to 7,000 Tc-99m syringes daily for road delivery to all of the nuclear medicine hospitals within a 3-hour range. At the current price of $20 per unit dose, the annual gross income from 10 sites would be approximately $360 million. The Homogeneous SLOWPOKE reactor evolved from the inherently safe SLOWPOKE-2 research reactor, with a double goal: replacing the heterogeneous SLOWPOKE-2 reactors at the end-of-core life, enabling them to continue their primary missions of research and education, together with full time commercial radioisotope production. The Homogeneous SLOWPOKE reactor was modelled using both deterministic and probabilistic reactor simulation codes. The homogeneous fuel mixture is a dilute aqueous solution of low-enriched uranyl sulfate containing approximately 1 kg of U-235. The reactor is controlled by mechanical absorber rods in the beryllium reflector. Safety analysis was carried out for both normal operation and transient conditions. The most severe

  14. Bernhard Linde. Noor-Eesti vooriülem. Bernhard Linde. Leader of the Young Estonian Pack

    Directory of Open Access Journals (Sweden)

    Jaanus Kulli

    2012-04-01

    Full Text Available Bernhard Linde (1886–1954 was a recognized and prolific Estonian theatre critic of the first quarter of the 20th century, who mediated and propagated western as well as eastern European theatrical innovations. In addition, he was active as a literary and art critic, publisher, and proponent of libraries, to a modest extent he was a prose writer and poet. Unquestionably, however, Bernhard Linde’s most prominent role was as one of the founding members of the literary movement Young Estonia. He was the group’s first general manager; later on, he was the secretary of the Estonian Writers’ Association Young Estonia, and the chairman of the board of the Young Estonia Publishing House. Linde’s formal education culminated in graduation from Tartu University as a Slavic philologist; he was the only member of the Young Estonia group to demonstrate serious and sustained interest toward Slavic cultures and peoples. Linde was a contradictory figure, evoking a range of responses from his contemporaries: on the one hand, there was the unbelievably broad range of his participation in cultural life, his organizing skills and business instincts in directing publishing houses; on the other hand, a superficiality in his writings, his often rash and subjective style as a critic, and his financial intrigues. If one adds in Linde’s stubbornness, egocentrism, and intense spirit of protest, which often led to lawsuits, the outcome is the portrait of an extremely complicated, fascinating, and passionate man—both in his creative work and his personal life Linde guaranteed a place for himself in literary history through a small catch of texts: a few foundational essays (for example, on August Kitzberg, a translation of Balzac’s Le père Goriot, the essay collection Omad ja võõrad (Own and Foreign and a travel book focusing on the literature and theatre of eastern Europe (Loova Kesk-Euroopa Poole (Toward A Creative Central Europe. The prominent public

  15. Reactor production and separation of no-carrier added 32P for medical applications

    International Nuclear Information System (INIS)

    Vimalnath, K.V.; Shetty, P.; Rajeswari, A.; Chirayil, V.; Chakraborty, S.; Dash, A.

    2014-01-01

    Phosphorous-32 is an attractive and widely used therapeutic radionuclide owing to its favorable nuclear characteristics. The major application of 32 P is the treatment option for a distinct subgroup of elderly patients with polycythemia vera and leukemia. The tremendous prospects associated with the use of 32 P along with the challenge of providing 32 P of acceptable specific activity and purity amenable for in vivo therapy, led to development of a 32 P production strategy. The 32 S(n,p) 32 P route of production provide the scope of obtaining high specific activities or no carrier added (NCA) 32 P. In a typical batch of 14 nos. of neutron irradiated Al containers, each containing 18 g of sulphur, were processed. In the quest for an effective separation method to isolate micro gram of 32 P formed during the neutron irradiation of sulphur, the prospect of using distillation under reduced pressure to achieve complete removal of sulfur seemed to be an effective proposition and motivated us to adopt. The experimental parameters that influence the distillation were identified and a careful control has been exercised to ensure complete removal of sulphur from 32 P within reasonable time period. The 32 P remained in the distillation flask was quantitatively collected by leaching with 0.05 N HCl with gentle heating at 80℃ for 3 hours. In the light of the perceived need to remove cationic impurities from the 32 P leachate, it was passed through an ion-exchange chromatography column containing a cation exchange resin (Dowex 50 x 8 H + , 100-200 mesh) wherein all the cationic impurities get trapped and H 3 32 PO 4 solution was collected as effluent. Recognizing the fact that H 3 32 PO 4 produced is to be used for clinical applications, a thorough quality assessment was carried out. Radionuclidic purity was ascertained by a measurement of its half-life. In order to establish the absence of extraneous gamma emitting radionuclide impurities, gamma spectrum of the appropriately

  16. Practices of radiation sterilization of medical products and pharmaceutical preparations: egyptian experience

    International Nuclear Information System (INIS)

    Roushdy, H.M.

    1992-01-01

    Radiation sterilization involves the application of sufficient ionizing energy furnished by either x-rays, gamma-rays or accelerated electron beams, to render an article free of viable micro-organisms. The method offers a number of advantages which makes it an attractive choice in a number of situations: It is a suitable means of sterilizing many many materials.. Radiation causes no significant temperature rise, thus permits sterilization of heat-sensitive drugs and low melting-point plastics. It is certainly the best, and often the only method of sterilizing biological tissues and preparations of biological origin. due to its high penetrating ability, gamma-radiation reaches all parts of the object to be sterilized. The radiation sterilized products are not subjected to touching or exposure to the outside environment except by the and users. The chemical reactivity of radiation is relatively low as compared with the highly reactive gases. Radiation can be easily adapted for continuous processing as compared with batch operations currently in use with gas sterilization. The radiation process is the most reliable of all competing sterilization methods due to the obsolete certainty that the radiation source emits radiation of known energy and power

  17. Medical isotope production experience at the V.G. Khlopin Radium Institute cyclotron

    International Nuclear Information System (INIS)

    Solin, L.M.

    2000-01-01

    Radium Institute cyclotron MGC-20 is used since 1990. There are four cyclotrons of such type in Russia and four abroad: in Finland, in Hungary, in North Korea and in Egypt. The Radium institute cyclotron was used in different fields, such as radioisotope production, nuclear physics, physics and engineering. For ten years some improvements of the Radium Institute cyclotron operation have been made. Those are: creation of the automatic control system based on IBM PC, development of a new power supply for the ion source, creation of the deflector electronic protection from discharges, change of the main elements of the cyclotron with high induced radioactivity. Moreover we investigated the possibility of the negative ions acceleration at the MGC-20 cyclotron without ion source exchange. The maximum value of the proton beam current reached was about 30 μA for 10 MeV H - beam energy. To extract the proton beam from the cyclotron after the stripping foil we made an additional output beam line. It was used for determination of the horizontal and vertical emittance. A special device was constructed and used for measurements of emittance. The latter amounted 30 π mm mrad for horizontal direction and 16 π mm mrad for vertical direction

  18. Source term estimates of radioxenon released from the BaTek medical isotope production facility using external measured air concentrations.

    Science.gov (United States)

    Eslinger, Paul W; Cameron, Ian M; Dumais, Johannes Robert; Imardjoko, Yudi; Marsoem, Pujadi; McIntyre, Justin I; Miley, Harry S; Stoehlker, Ulrich; Widodo, Susilo; Woods, Vincent T

    2015-10-01

    BATAN Teknologi (BaTek) operates an isotope production facility in Serpong, Indonesia that supplies (99m)Tc for use in medical procedures. Atmospheric releases of (133)Xe in the production process at BaTek are known to influence the measurements taken at the closest stations of the radionuclide network of the International Monitoring System (IMS). The purpose of the IMS is to detect evidence of nuclear explosions, including atmospheric releases of radionuclides. The major xenon isotopes released from BaTek are also produced in a nuclear explosion, but the isotopic ratios are different. Knowledge of the magnitude of releases from the isotope production facility helps inform analysts trying to decide if a specific measurement result could have originated from a nuclear explosion. A stack monitor deployed at BaTek in 2013 measured releases to the atmosphere for several isotopes. The facility operates on a weekly cycle, and the stack data for June 15-21, 2013 show a release of 1.84 × 10(13) Bq of (133)Xe. Concentrations of (133)Xe in the air are available at the same time from a xenon sampler located 14 km from BaTek. An optimization process using atmospheric transport modeling and the sampler air concentrations produced a release estimate of 1.88 × 10(13) Bq. The same optimization process yielded a release estimate of 1.70 × 10(13) Bq for a different week in 2012. The stack release value and the two optimized estimates are all within 10% of each other. Unpublished production data and the release estimate from June 2013 yield a rough annual release estimate of 8 × 10(14) Bq of (133)Xe in 2014. These multiple lines of evidence cross-validate the stack release estimates and the release estimates based on atmospheric samplers. Copyright © 2015 Elsevier Ltd. All rights reserved.

  19. Production and immobilization of alpha amylase using biotechnology techniques for use in biological and medical applications

    International Nuclear Information System (INIS)

    Mobasher, E.E.F.

    2009-01-01

    The immobilized enzymes on polymeric supports are prepared for purpose of repeated use and the possibilities of continuous reaction system. One of the most important properties is the stability of proteins when they are used in some medical and industrial applications. The immobilization of the enzymes improves this property as well as many other properties.In this study, alpha amylase was purified and immobilized onto two different polymers. α- amylase was used in this study for its biological and industrial applications. It is used in paper textile, pharmaceutical applications, food, and detergent industries. α- amylase was found in plants, animals, and microorganisms. Purification of α-amylase from microorganisms is the main source of α-amylase because it was excreted from many bacteria and fungi. In this study, α-amylase was purified from Aspergillus niger. Fractional precipitation of the α- amylase produced by A. niger with 80% ammonium sulphate saturation. The crude enzyme was applied on column chromatography packed with Sephadex G 100 for purification. The active eluents containing partially purified enzyme were collected for further investigation. The specific activity of α-amylase was (34.9 U/mg) which was corresponding to 2.09 fold purification for the tested organism. The purified α-amylase was immobilized by entrapment method into two types of polymers. One of them was natural consist of chitosan and alginate. The other polymer was synthetic consist of N- isopropyl acrylamide and alginate. The temperature optimum and thermal inactivation showed a severe loss in the activity of the free enzymes, while the temperature profile of the immobilized enzymes was much broader at higher temperatures demonstrating the effectiveness of the polymer protecting the enzymes. Also, the immobilized enzymes (natural polymer and synthetic polymer) showed higher thermal stability. Optimum ph and stability showed that immobilization of enzymes resulted in more

  20. Composite β-κ-casein genotypes and their effect on composition and coagulation of milk from Estonian Holstein cows.

    Science.gov (United States)

    Vallas, M; Kaart, T; Värv, S; Pärna, K; Jõudu, I; Viinalass, H; Pärna, E

    2012-11-01

    The objective of this study was to estimate the effect of composite β-κ-CN genotypes on milk coagulation and composition traits, and on the additive genetic variation of these traits in Estonian Holstein dairy cattle. A total of 23,970 milk samples, repeated measurements from the first to third lactation from 2,859 Estonian Holstein cows from 78 herds across the country, were analyzed for milk yield, milk fat and protein percentages, somatic cell count, and milk coagulation properties (milk coagulation time and curd firmness). Each cow had at least 3 measurements per lactation. Two single-trait random regression animal models were fitted for the traits studied. The first model considered fixed effects of year-season of sampling and year-season of calving, calving age (nested within lactation), sample age (only for milk coagulation traits) and days in milk, and random herd, additive genetic, and permanent environmental effects. The animal and permanent environmental effects were modeled over the lactation period by using Legendre polynomials. The second model had the additional fixed β-κ-casein effect in the form of a third-order Legendre polynomial. The 2 most frequent β-κ-casein composite genotypes were A2A2AA and A1A2AA, both with prevalence greater than 20%. Percentages of the remaining 31 genotypes were less than 8%, including 20 genotypes with percentages less than 1%. The β-κ-casein genotype-specific lactation curves were significantly different for milk coagulation traits and milk protein percentage. The B variant of κ-casein showed a favorable effect on both milk coagulation traits, whereas the IB haplotype had an increasing effect on curd firmness and protein percentage. Inclusion of the β-κ-casein genotype effects in the model resulted in decreases in the mean additive genetic variations for milk coagulation time and curd firmness of 12.9 and 51.1%, respectively. Copyright © 2012 American Dairy Science Association. Published by Elsevier Inc

  1. Experiences of a long-term randomized controlled prevention trial in a maiden environment: Estonian Postmenopausal Hormone Therapy trial

    Directory of Open Access Journals (Sweden)

    Rahu Mati

    2008-08-01

    Full Text Available Abstract Background Preventive drugs require long-term trials to show their effectiveness or harms and often a lot of changes occur during post-marketing studies. The purpose of this article is to describe the research process in a long-term randomized controlled trial and discuss the impact and consequences of changes in the research environment. Methods The Estonian Postmenopausal Hormone Therapy trial (EPHT, originally planned to continue for five years, was planned in co-operation with the Women's International Study of Long-Duration Oestrogen after Menopause (WISDOM in the UK. In addition to health outcomes, EPHT was specifically designed to study the impact of postmenopausal hormone therapy (HT on health services utilization. Results After EPHT recruited in 1999–2001 the Women's Health Initiative (WHI in the USA decided to stop the estrogen-progestin trial after a mean of 5.2 years in July 2002 because of increased risk of breast cancer and later in 2004 the estrogen-only trial because HT increased the risk of stroke, decreased the risk of hip fracture, and did not affect coronary heart disease incidence. WISDOM was halted in autumn 2002. These decisions had a major influence on EPHT. Conclusion Changes in Estonian society challenged EPHT to find a balance between the needs of achieving responses to the trial aims with a limited budget and simultaneously maintaining the safety of trial participants. Flexibility was the main key for success. Rapid changes are not limited only to transiting societies but are true also in developed countries and the risk must be included in planning all long-term trials. The role of ethical and data monitoring committees in situations with emerging new data from other studies needs specification. Longer funding for preventive trials and more flexibility in budgeting are mandatory. Who should prove the effectiveness of an (old drug for a new preventive indication? In preventive drug trials companies may

  2. Greater loss of productivity among Japanese workers with gastro-esophageal reflux disease (GERD) symptoms that persist vs resolve on medical therapy.

    Science.gov (United States)

    Suzuki, H; Matsuzaki, J; Masaoka, T; Inadomi, J M

    2014-06-01

    Gastro-esophageal reflux disease (GERD) impairs quality of life; however, the association between GERD and work productivity has not been well investigated in Japan. This study was designed to compare the impact of GERD on productivity between Japanese workers with GERD symptoms that persisted vs resolved on medical therapy. A cross-sectional Web-based survey was conducted in workers. The impact of GERD on work and daily productivity was evaluated using a Web-reported Work Productivity and Activity Impairment Questionnaire for patients with GERD and a GERD symptom severity Questionnaire. Demographic information, clinical history, and satisfaction with GERD medication were also ascertained. A total of 20 000 subjects were invited to the survey. After the exclusion of patients with a history of gastrointestinal (GI) malignancy, peptic ulcer, upper GI surgery, and unemployment, 650 participants were included in the analysis. Participants with persistent GERD symptoms reported a significantly greater losses of work productivity (11.4 ± 13.4 h/week), absenteeism (0.7 ± 3.1 h/week), presenteeism (10.7 ± 12.6 h/week), costs (20 100 ± 26 800 JPY/week), and lower daily productivity (71.3% [95% confidence interval, 69.0-73.7]) than those whose symptoms were alleviated with medications. The level of dissatisfaction with GERD medications among participants with persistent GERD symptoms was significantly correlated with loss of work and daily productivity (p productivity despite medical therapy. Ineffective GERD therapy is associated with greater productivity loss. © 2014 John Wiley & Sons Ltd.

  3. Voluntary medical male circumcision scale-up in Nyanza, Kenya: evaluating technical efficiency and productivity of service delivery.

    Science.gov (United States)

    Omondi Aduda, Dickens S; Ouma, Collins; Onyango, Rosebella; Onyango, Mathews; Bertrand, Jane

    2015-01-01

    Voluntary medical male circumcision (VMMC) service delivery is complex and resource-intensive. In Kenya's context there is still paucity of information on resource use vis-à-vis outputs as programs scale up. Knowledge of technical efficiency, productivity and potential sources of constraints is desirable to improve decision-making. To evaluate technical efficiency and productivity of VMMC service delivery in Nyanza in 2011/2012 using data envelopment analysis. Comparative process evaluation of facilities providing VMMC in Nyanza in 2011/2012 using output orientated data envelopment analysis. Twenty one facilities were evaluated. Only 1 of 7 variables considered (total elapsed operation time) significantly improved from 32.8 minutes (SD 8.8) in 2011 to 30 minutes (SD 6.6) in 2012 (95%CI = 0.0350-5.2488; p = 0.047). Mean scale technical efficiency significantly improved from 91% (SD 19.8) in 2011 to 99% (SD 4.0) in 2012 particularly among outreach compared to fixed service delivery facilities (CI -31.47959-4.698508; p = 0.005). Increase in mean VRS technical efficiency from 84% (SD 25.3) in 2011 and 89% (SD 25.1) in 2012 was not statistically significant. Benchmark facilities were #119 and #125 in 2011 and #103 in 2012. Malmquist Productivity Index (MPI) at fixed facilities declined by 2.5% but gained by 4.9% at outreach ones by 2012. Total factor productivity improved by 83% (p = 0.032) in 2012, largely due to progress in technological efficiency by 79% (p = 0.008). Significant improvement in scale technical efficiency among outreach facilities in 2012 was attributable to accelerated activities. However, ongoing pure technical inefficiency requires concerted attention. Technological progress was the key driver of service productivity growth in Nyanza. Incorporating service-quality dimensions and using stepwise-multiple criteria in performance evaluation enhances comprehensiveness and validity. These findings highlight site-level resource use and sources of

  4. Sustainable clinical research, health economic aspects and medical marketing: drivers of product innovation.

    Science.gov (United States)

    Haschke, Ferdinand; Klassen-Wigger, Petra

    2010-01-01

    Marketing-driven innovation in the field of pediatric nutrition, in particular in the infant formula segment is not sustainable. New benefits of products must be scientifically proven and safety and efficacy of new formulae established in clinical trials. The scientific innovation process of three infant formulae is described. Improvement in protein quality allowed to reduce the protein concentration in whey-based infant formula. Weight gain and BMI of infants fed those formulae corresponds to breastfed infants and is lower than in infants fed traditional formulae with higher protein concentration. A meta-analysis indicates associations between rapid weight gain in infancy and obesity later in life. If infants cannot be exclusively breastfed until 4-6 months of age, feeding low-protein formulae may contribute to positive long-term health outcome with potentially important health economic effects. A partially hydrolyzed whey based formula for prevention of allergic symptoms in children with hereditary risk for allergic diseases was developed more than 25 years ago. The most recent meta-analysis which included 15 randomized clinical trials indicates that the risk of all allergic diseases and atopic dermatitis/eczema is significantly reduced in infants at risk when the partially hydrolyzed formula is fed. The partially hydrolyzed formula had the same protective effect as casein-based high-degree extensively hydrolyzed formula. Because of substantial price differences between the two formulae, feeding the partially hydrolyzed whey formula is cost saving. Hypoallergenic claims can be made in many countries, and international nutrition committees have positively commented the preventive effect of those formulae. Acidified formulae have been widely used during the last decade in replacement feeding programs for infants whose mothers are HIV positive. The formula was innovated by improving whey protein quality and lowering protein concentration. The bacteriostatic

  5. Source Term Estimates of Radioxenon Released from the BaTek Medical Isotope Production Facility Using External Measured Air Concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Eslinger, Paul W.; Cameron, Ian M.; Dumais, Johannes R.; Imardjoko, Yudi; Marsoem, Pujadi; McIntyre, Justin I.; Miley, Harry S.; Stoehlker, Ulrich; Widodo, Susilo; Woods, Vincent T.

    2015-10-01

    Abstract Batan Teknologi (BaTek) operates an isotope production facility in Serpong, Indonesia that supplies 99mTc for use in medical procedures. Atmospheric releases of Xe-133 in the production process at BaTek are known to influence the measurements taken at the closest stations of the International Monitoring System (IMS). The purpose of the IMS is to detect evidence of nuclear explosions, including atmospheric releases of radionuclides. The xenon isotopes released from BaTek are the same as those produced in a nuclear explosion, but the isotopic ratios are different. Knowledge of the magnitude of releases from the isotope production facility helps inform analysts trying to decide whether a specific measurement result came from a nuclear explosion. A stack monitor deployed at BaTek in 2013 measured releases to the atmosphere for several isotopes. The facility operates on a weekly cycle, and the stack data for June 15-21, 2013 show a release of 1.84E13 Bq of Xe-133. Concentrations of Xe-133 in the air are available at the same time from a xenon sampler located 14 km from BaTek. An optimization process using atmospheric transport modeling and the sampler air concentrations produced a release estimate of 1.88E13 Bq. The same optimization process yielded a release estimate of 1.70E13 Bq for a different week in 2012. The stack release value and the two optimized estimates are all within 10 percent of each other. Weekly release estimates of 1.8E13 Bq and a 40 percent facility operation rate yields a rough annual release estimate of 3.7E13 Bq of Xe-133. This value is consistent with previously published estimates of annual releases for this facility, which are based on measurements at three IMS stations. These multiple lines of evidence cross-validate the stack release estimates and the release estimates from atmospheric samplers.

  6. Evaluation of Facebook and Twitter Monitoring to Detect Safety Signals for Medical Products: An Analysis of Recent FDA Safety Alerts.

    Science.gov (United States)

    Pierce, Carrie E; Bouri, Khaled; Pamer, Carol; Proestel, Scott; Rodriguez, Harold W; Van Le, Hoa; Freifeld, Clark C; Brownstein, John S; Walderhaug, Mark; Edwards, I Ralph; Dasgupta, Nabarun

    2017-04-01

    The rapid expansion of the Internet and computing power in recent years has opened up the possibility of using social media for pharmacovigilance. While this general concept has been proposed by many, central questions remain as to whether social media can provide earlier warnings for rare and serious events than traditional signal detection from spontaneous report data. Our objective was to examine whether specific product-adverse event pairs were reported via social media before being reported to the US FDA Adverse Event Reporting System (FAERS). A retrospective analysis of public Facebook and Twitter data was conducted for 10 recent FDA postmarketing safety signals at the drug-event pair level with six negative controls. Social media data corresponding to two years prior to signal detection of each product-event pair were compiled. Automated classifiers were used to identify each 'post with resemblance to an adverse event' (Proto-AE), among English language posts. A custom dictionary was used to translate Internet vernacular into Medical Dictionary for Regulatory Activities (MedDRA ® ) Preferred Terms. Drug safety physicians conducted a manual review to determine causality using World Health Organization-Uppsala Monitoring Centre (WHO-UMC) assessment criteria. Cases were also compared with those reported in FAERS. A total of 935,246 posts were harvested from Facebook and Twitter, from March 2009 through October 2014. The automated classifier identified 98,252 Proto-AEs. Of these, 13 posts were selected for causality assessment of product-event pairs. Clinical assessment revealed that posts had sufficient information to warrant further investigation for two possible product-event associations: dronedarone-vasculitis and Banana Boat Sunscreen--skin burns. No product-event associations were found among the negative controls. In one of the positive cases, the first report occurred in social media prior to signal detection from FAERS, whereas the other case

  7. FOCJ as model for financing the Estonian general education. FOCJ-mudel Eesti üldhariduse rahastamiseks

    Directory of Open Access Journals (Sweden)

    Peter Friedrich

    2012-01-01

    Full Text Available The share of GDP used for financing education in Estonia is somewhat lower in comparison to the EU average, the nominal amount of per capita education funds is much more lower due to a low level of economic development. Moreover, because of thin population per square km many small schools exist in Estonia without a sufficient number of pupils, which makes the education system more costly. We consider two different basic strategies to improve the situation. The current strategy of financing Estonian general education refers mainly to the prevailing educational and spatial organization. This strategy is not based on a fair equal treatment of cases. Therefore a new strategy of improvement of education financing system is discussed. It is based on the idea of Functional Overlapping Competitive Jurisdictions (FOCJ. The municipalities voluntarily form FOCJ that are operating schools. In this way municipalities may form a school jurisdiction that can negotiate with central government institutions for the loan and the school equipment etc. A municipality can act individually or the FOCJ negotiates for the municipal members in total. Theories of FOCJ-establishment, FOCJ-contribution determination and FOCJ-negotiations with central government are demonstrated. The FOCJ can supplement positively the first strategy of reform.

  8. The effects of political and economic transitions on health and safety in Estonia: an Estonian-Swedish comparative study.

    Science.gov (United States)

    Kaasik, T; Andersson, R; Hörte, L G

    1998-11-01

    A general and dramatic deterioration of health in Estonia during the transition period 1990-1994 was analysed using Sweden as a comparative example. Though there were diverging trends between Estonia and Sweden in the leading cause of death, cardiovascular diseases, the gap in mortality from injury had increased most rapidly. While the injury mortality rate slightly decreased in Sweden from 1990 to 1994, it almost doubled in Estonia. In 1994, the total injury death rate for men was about 6 times higher in Estonia than in Sweden. The death rates for some types of injuries, such as alcohol intoxication and homicide, were many tenfolds higher in Estonia than in Sweden. Injury contributed the most to the widening health gap between the countries, especially in males. The mechanisms of this sudden health deterioration remain to be fully explained. It could be hypothesised that behind the traditional behavioural risk factors, the influence of socio-political factors related to economic and political reconstruction is present. A widespread risk-taking and unhealthy behaviour among Estonians can likely be partly explained as a way of coping with the distress created by the new demands of transition society. An important challenge on the way to improvement is creating the political will among policy-makers to confront the tremendous problems of controlling the factors in society that affect the population's health in Estonia.

  9. Disparities in US Healthcare Provider Screening and Advice for Cessation Across Chronic Medical Conditions and Tobacco Products.

    Science.gov (United States)

    Keith, Diana R; Stanton, Cassandra A; Gaalema, Diann E; Bunn, Janice Y; Doogan, Nathan J; Redner, Ryan; Kurti, Allison N; Cepeda-Benito, Antonio; Lopez, Alexa A; Morehead, Adam L; Roberts, Megan E; Higgins, Stephen T

    2017-09-01

    Disparities in tobacco use are worsening in the United States, disproportionately affecting those with chronic medical conditions. One possible contributor is that physicians may not screen and advise cessation uniformly across patients and/or tobacco products. This study examined provider communications regarding cigarette and non-cigarette tobacco products among adults with chronic conditions. Cross-sectional study drawn from two waves (2013-2014) of the National Survey on Drug Use and Health (NSDUH). Adults (≥ 18 years) who used tobacco in the past year. Prevalence of tobacco use included past-year use of cigarettes, cigars, or smokeless tobacco among those with and without chronic conditions. Chronic conditions included asthma, anxiety, coronary heart disease, depression, diabetes, hepatitis, HIV, hypertension, lung cancer, stroke, and substance abuse. Odds ratio of receipt of screening and advice to quit across chronic condition and tobacco product type were reported. Data were analyzed using logistic regression, controlling for basic sociodemographic factors and number of provider visits. Adults with anxiety, depression, and substance use disorders had the highest prevalence of past-year cigarette (37.2-58.2%), cigar (9.1-28.0%), and smokeless tobacco (3.1-11.7%) use. Patients with any chronic condition were more likely to receive advice to quit than those without a condition (OR 1.21-2.37, p < 0.01), although the odds were lowest among adults with mental health and substance use disorders (OR 1.21-1.35, p < 0.01). Cigarette smokers were more likely to report being screened and advised to quit than non-cigarette tobacco users (OR 1.54-5.71, p < 0.01). Results support the need for provider training to expand screening and cessation interventions to include the growing spectrum of tobacco products. Screening and referral to interventions are especially needed for those with mental health and substance use disorders to reduce the disparate burden of

  10. Innovation of Medical Products

    DEFF Research Database (Denmark)

    Spindler, Per; Bach, Karin Friis; Schmiegelow, Merete

    2016-01-01

    We present a commentary on the international aspects of the evolution of regulatory science as a multidisciplinary, multistakeholder academic discipline of education and applied research emphasizing the need for seamless interaction between stakeholders such as regulatory authorities, the pharmac......We present a commentary on the international aspects of the evolution of regulatory science as a multidisciplinary, multistakeholder academic discipline of education and applied research emphasizing the need for seamless interaction between stakeholders such as regulatory authorities...

  11. [Results of a standardized survey on the medical use of cannabis products in the German-speaking area].

    Science.gov (United States)

    Schnelle, M; Grotenhermen, F; Reif, M; Gorter, R W

    1999-10-01

    The plant Cannabis sativa has a long history of medical use in the treatment of pain and spasms, the promotion of sleep, and the suppression of nausea and vomiting. However, in the early 70s cannabis was classified in the Narcotic Acts in countries all over the world as having no therapeutic benefit; therefore, it cannot be prescribed by physicians or dispensed by pharmacists. In the light of this contradictory situation an increasing number of patients practices a self-prescription with cannabis products for relieving a variety of symptoms. An anonymous standardized survey of the medical use of cannabis and cannabis products of patients in Germany, Austria and Switzerland was conducted by the Association for Cannabis as Medicine (Cologne, Germany). During about one year 170 subjects participated in this survey; questionnaires of 128 patients could be included into the evaluation. 68% of these participants were males, 32% females, with a total mean age of 37.5 (+/- 9.6) years. The most frequently mentioned indications for medicinal cannabis use were depression (12.0%), multiple sclerosis (10.8%), HIV-infection (9.0%), migraine (6.6%), asthma (6.0%), back pain (5.4%), hepatitis C (4. 8%), sleeping disorders (4.8%), epilepsy (3.6%), spasticity (3.6%), headache (3.6%), alcoholism (3.0%), glaucoma (3.0%), nausea (3.0%), disk prolapse (2.4%), and spinal cord injury (2.4%). The majority of patients used natural cannabis products such as marihuana, hashish and an alcoholic tincture; in just 5 cases dronabinol (Marinol) was taken by prescription. About half of the 128 participants of the survey (52.4%) had used cannabis as a recreational drug before the onset of their illness. To date 14.3% took cannabis orally, 49.2% by inhalation and in 36.5% of cases both application modes were used. 72.2% of the patients stated the symptoms of their illness to have 'much improved' after cannabis ingestion, 23.4% stated to have 'slightly improved', 4.8% experienced 'no change' and 1

  12. Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence.

    Science.gov (United States)

    Lopez, Janice Ms; Annunziata, Kathy; Bailey, Robert A; Rupnow, Marcia Ft; Morisky, Donald E

    2014-01-01

    The purpose of this study was to determine the characteristics of adults with type 2 diabetes mellitus (T2DM) that correlate with greater risk of hypoglycemia and determine the impact of hypoglycemia on health-related quality of life, work productivity, and medication adherence from a patient perspective. Data from a large web-based survey were retrospectively analyzed. Adults with a diagnosis of T2DM taking antihyperglycemic agents were included in the analysis. Participants with knowledge of their hypoglycemic history were divided into three groups: those experiencing recent hypoglycemia (previous 3 months), those experiencing nonrecent hypoglycemia, and those never experiencing hypoglycemia. Of the participants with T2DM taking antihyperglycemic agents who were knowledgeable of their hypoglycemia history, 55.7% had ever experienced hypoglycemia. Of those, 52.7% had recent hypoglycemia. Compared with those who never experienced hypoglycemia, those who experienced hypoglycemia tended to: be younger; be more aware of their glycated hemoglobin (HbA1c) levels; have higher HbA1c levels; have a higher body mass index; have higher Charlson Comorbidity Index scores; be on insulin, sulfonylureas, and/or glucagon-like peptide-1 agonists; and be less adherent to their antihyperglycemic agents. Hypoglycemia interfered with social activities, caused more missed work (absenteeism), more impairment while at work (presenteeism), and decreased overall work productivity compared with patients who had never experienced hypoglycemia. Overall health-related quality of life, as determined by the Short Form-36 health questionnaire, was negatively impacted by hypoglycemia. Both Physical and Mental Summary scores were significantly lower for the recent hypoglycemia and nonrecent hypoglycemia groups compared with the never hypoglycemia group. Hypoglycemia can negatively impact many aspects of life. Greater awareness of those who are at risk for developing hypoglycemia can lead to the

  13. Medical alert bracelet (image)

    Science.gov (United States)

    People with diabetes should always wear a medical alert bracelet or necklace that emergency medical workers will be able to find. Medical identification products can help ensure proper treatment in an ...

  14. Noor-Eesti enesekoloniseerimisprojekt. Teine osa Olulised kirjandusmõtteviisid . The Self-Colonization Project of Young Estonia. Part II. Modes of Literary Thinking and Relations with Colonialism in Estonian Literature of the beginning of the 20th century

    Directory of Open Access Journals (Sweden)

    Tiit Hennoste

    2012-04-01

    Full Text Available The topic of this article is the literary discourse of Young Estonia; its relations with other important Estonian literary discourses from the beginning of the 20th century, and its relations with colonial cultural discourse. First, I give an overview of the basic positions of the Young Estonians’ literary discourse, the main shapers of which were Friedebert Tuglas, Gustav Suits, later on Johannes Semper as well. Next, I present the basic principles of three Estonian literary discourses from the beginning of the 20th century, which were also important to the Young Estonians: nationalist-naturalistic (close-to-life; socialist/ class-based, and 20th century modernist. The Young Estonians began as nationalists and/or socialists. During the formation of Young Estonia’s discourse at the end of the first and beginning of the second decade of the 20th century, 20th century modernism began, which the Young Estonians regarded first and foremost with irony. The Young Estonians’ literary discourse is a mixture of aestheticism, decadence, symbolism, romanticism, and classicism. The point of departure for the Young Estonian approach to literature was eurocentrism. They took a superior and negative view of existing Estonian literature, which they regarded as having fallen drastically behind Europe. Since it was unable to build on its own foundation, it had to borrow from Europe. The discourse’s understandings of cultural values – theory, reading, knowledge, ready-made culture, derive from the centrality of the dynamic of borrowing. New culture could be created freely, without the support of previous local tradition; it was to be an elite culture, while the writer remained an individualist. Literature was to follow the principle of art for art’s sake; aesthetics and the form of the work of art were basic criteria. The formal ideals of the work of art were classicist: unity, integrity (wholeness, harmony, order, logic, etc. Thirdly, I outline the

  15. Short rotation willow coppice for renewable energy and improved environment. Proceedings of a joint Swedish - Estonian seminar on energy forestry and vegetation filters

    International Nuclear Information System (INIS)

    Perttu, K.; Koppel, A.

    1996-01-01

    The overall aim of the present seminar was to present and discuss results from the joint Swedish - Estonian energy forestry research activities during the period of 1993-1995 and to publish the papers in a technical report. The results is a publication, presenting interesting methods and results, and is meant partly to serve as the final report of the joint efforts during the period mentioned, partly to be used for future planning of new projects and for application of funding for a continued cooperation. Separate abstracts have been prepared for all of the 17 papers in the report

  16. Rural retention of new medical graduates from the Collaborative Project to Increase Production of Rural Doctors (CPIRD): a 12-year retrospective study.

    Science.gov (United States)

    Techakehakij, Win; Arora, Rajin

    2017-07-01

    Physician scarcity in rural areas is a major obstacle to healthcare access, leading to health inequity worldwide. In Thailand, a special recruitment program of medical education [Collaborative Project to Increase Production of Rural Doctors (CPIRD)] was initiated with four different medical training tracks. No previous research has examined the rural retention of new medical graduates across the CPIRD tracks, compared with those receiving conventional medical education (Normal track). This study examines the public retention of rural physicians from different tracks of entry. A retrospective study was conducted in new medical graduates who entered Ministry of Public Health (MoPH) hospitals from January 2003 to October 2014, and followed up until June 2015, using administrative data from the Personnel Administration Division, MoPH. The CPIRD registry database was used to identify physicians' tracks of entry. Survival analyses and multiple logistic regression analyses were applied to compare the annual retention and the probability of 3-year retention of rural physicians. Results clearly demonstrated a high rural retention of CPIRD medical graduates, compared with their Normal track peers, regarding both lower annual resignation (HR 0.456, P rural retention were revealed across the different CPIRD tracks. Evidence from this study can be used as part of the information to reshape the physician production policy to reduce health inequity in rural areas. © The Author 2017. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  17. Can we use social media to support content validity of patient-reported outcome instruments in medical product development?

    Science.gov (United States)

    Rothman, Margaret; Gnanaskathy, Ari; Wicks, Paul; Papadopoulos, Elektra J

    2015-01-01

    We report a panel designed to open a dialog between pharmaceutical sponsors, regulatory reviewers, and other stakeholders regarding the use of social media to collect data to support the content validity of patient-reported outcome instruments in the context of medical product labeling. Multiple stakeholder perspectives were brought together to better understand the issues encountered in pursuing social media as a form of data collection to support content validity. Presenters represented a pharmaceutical sponsor of clinical trials, a regulatory reviewer from the Food and Drug Administration, and an online data platform provider. Each presenter shared its perspective on the advantages and disadvantages of using social media to collect this type of information. There was consensus that there is great potential for using social media for this purpose. There remain, however, unanswered questions that need to be addressed such as identifying which type of social media is most appropriate for data collection and ensuring that participants are representative of the target population while maintaining the advantages of anonymity provided by online platforms. The use of social media to collect evidence of content validity holds much promise. Clarification of issues that need to be addressed and accumulation of empirical evidence to address these questions are essential to moving forward. Copyright © 2015 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc. All rights reserved.

  18. Measurement of DNA biomarkers for the safety of tissue-engineered medical products, using artificial skin as a model.

    Science.gov (United States)

    Rodriguez, Henry; O'Connell, Catherine; Barker, Peter E; Atha, Donald H; Jaruga, Pawel; Birincioglu, Mustafa; Marino, Michael; McAndrew, Patricia; Dizdaroglu, Miral

    2004-01-01

    To test the hypothesis that the process of tissue engineering introduces genetic damage to tissue-engineered medical products, we employed the use of five state-of-the-art measurement technologies to measure a series of DNA biomarkers in commercially available tissue-engineered skin as a model. DNA was extracted from the skin and compared with DNA from cultured human neonatal control cells (dermal fibroblasts and epidermal keratinocytes) and adult human fibroblasts from a 55-year-old donor and a 96-year-old donor. To determine whether tissue engineering caused oxidative DNA damage, gas chromatography/isotope-dilution mass spectrometry and liquid chromatography/isotope-dilution mass spectrometry were used to measure six oxidatively modified DNA bases as biomarkers. Normal endogenous levels of the modified DNA biomarkers were not elevated in tissue-engineered skin when compared with control cells. Next, denaturing high-performance liquid chromatography and capillary electrophoresis-single strand conformation polymorphism were used to measure genetic mutations. Specifically, the TP53 tumor suppressor gene was screened for mutations, because it is the most commonly mutated gene in skin cancer. The tissue-engineered skin was found to be free of TP53 mutations at the level of sensitivity of these measurement technologies. Lastly, fluorescence in situ hybridization was employed to measure the loss of Y chromosome, which is associated with excessive cell passage and aging. Loss of Y chromosome was not detected in the tissue-engineered skin and cultured neonatal cells used as controls. In this study, we have demonstrated that tissue engineering (for TestSkin II) does not introduce genetic damage above the limits of detection of the state-of-the-art technologies used. This work explores the standard for measuring genetic damage that could be introduced during production of novel tissue-engineered products. More importantly, this exploratory work addresses technological

  19. Common market but divergent regulatory practices: exploring European regulation and the effect on regulatory uncertainty in the marketing authorization of medical products

    NARCIS (Netherlands)

    Chowdhury, Nupur

    2013-01-01

    The medical product sector is characterised by a regulatory patchwork of European and national laws and guidelines operating concurrently with each other. Each of these sectors are characterised by different levels of regulatory uncertainty that may undermine the effectiveness of the regulatory

  20. Polycyclic aromatic hydrocarbons (PAHs) in meat products and estimated PAH intake by children and general population in Estonia

    OpenAIRE

    2007-01-01

    Abstract The concentrations of benzo(a)pyrene and 11 other polycyclic aromatic hydrocarbons (PAHs) were analysed from 322 commercial cured meat products and 14 home-grilled meat samples as part of the Estonian food safety monitoring programme during 2001-2005. The maximum acceptable concentration of 5 ?g kg-1 for benzo(a)pyrene was exceeded in 3.4% of analyzed samples. Highest PAH concentrations were detected in home-grilled pork samples. Using of disposable grilling unit resulted ...

  1. Accuracy of drug advertisements in medical journals under new law regulating the marketing of pharmaceutical products in Switzerland.

    Science.gov (United States)

    Santiago, Macarena Gonzalez; Bucher, Heiner C; Nordmann, Alain J

    2008-12-31

    New legal regulations for the marketing of pharmaceutical products were introduced in 2002 in Switzerland. We investigated whether claims in drug advertisements citing published scientific studies were justified by these studies after the introduction of these new regulations. In this cross-sectional study, two independent reviewers screened all issues of six major Swiss medical journals published in the year 2005 to identify all drug advertisements for analgesic, gastrointestinal and psychopharmacologic drugs and evaluated all drug advertisements referring to at least one publication. The pharmaceutical claim was rated as being supported, being based on a potentially biased study or not to be supported by the cited study according to pre-specified criteria. We also explored factors likely to be associated with supported advertisement claims. Of 2068 advertisements 577 (28%) promoted analgesic, psychopharmacologic or gastrointestinal drugs. Among them were 323 (56%) advertisements citing at least one reference. After excluding multiple publications of the same drug advertisement and advertisements with non-informative references, there remained 29 unique advertisements with at least one reference to a scientific study. These 29 advertisements contained 78 distinct pairs of claims of analgesic, gastrointestinal and psychopharmacologic drugs and referenced studies. Thirty-seven (47%) claims were supported, 16 (21%) claims were not supported by the corresponding reference, and 25 (32%) claims were based on potentially biased evidence, with no relevant differences between drug groups. Studies with conflict of interest and studies stating industry funding were more likely to support the corresponding claim (RR 1.52, 95% CI 1.07-2.17 and RR 1.50, 95% CI 0.98-2.28) than studies without identified conflict of interest and studies without information on type of funding. Following the introduction of new regulations for drug advertisement in Switzerland, 53% of all assessed

  2. Summary report of the consultants' meeting on improvements in charged-particle monitor reactions and nuclear data for medical isotope production

    International Nuclear Information System (INIS)

    Capote Noy, R.; Nortier, F.M.

    2011-09-01

    A Consultants' Meeting on 'Improvements in Charged-Particle Monitor Reactions and Nuclear Data for Medical Isotope Production' was held at IAEA Headquarters, Vienna, Austria to define the scope, deliverables and appropriate work programme of a possible Coordinated Research Project (CRP) on the subject. The main data areas requiring improvements are monitor reactions for charged-particle beams, production of novel positron emitters, and production of alpha emitters. In all these areas special attention was also given to the need for measurements and re-evaluations of decay data. Detailed deliverables of the planned CRP were proposed. (author)

  3. The screening of SLC6A8 deficiency among Estonian families with X-linked mental retardation.

    Science.gov (United States)

    Puusepp, H; Kall, K; Salomons, G S; Talvik, I; Männamaa, M; Rein, R; Jakobs, C; Õunap, K

    2010-12-01

    The urinary creatine:creatinine (Cr:Crn) ratio was measured in males from 49 families with a family history compatible with X-linked mental retardation (XLMR) in order to estimate the prevalence of SLC6A8 deficiency in Estonia. We identified 11 boys from 9 families with an increased urinary Cr:Crn ratio (18%). In three related boys, a hemizygous missense mutation (c.1271G>A; p.Gly424Asp) was identified. Their mother was heterozygous for the same mutation. Although many missense mutations have been described, the p.Gly424Asp mutation has not been previously reported. The clinical expression varied widely among affected males of this family. Patients 1 and 3 had relatively mild clinical expression (mild mental retardation (MR) and attention deficit disorder), but patient 2 had all typical clinical signs of SLC6A8 defect such as moderate MR, autistic features, expressive dysphasia and epilepsy. Among our patients, we saw significant problems in speech and language development combined with attention and behavioural difficulties. The number of false-positive biochemical results with increased urinary Cr:Crn ratio was higher (18%) in our study than in previous reports (1.8–10%). We therefore suggest that repeated biochemical testing should be performed before DNA sequencing analysis. Our study suggests that 2% (95% confidence limits: 0.05–11.1%) of this Estonian XLMR panel are due to mutations in the SLC6A8, which is similar to the prevalence reported in other populations. We therefore conclude that creatine transporter deficiency is a relatively common genetic disorder in males with sporadic or familiar MR and diagnostic screening of them should always include screening for SLC6A8 deficiency.

  4. The occurrence and extent of Helicobacter pylori colonization and antral and body gastritis profiles in an Estonian population sample.

    Science.gov (United States)

    Maaroos, H I; Kekki, M; Villako, K; Sipponen, P; Tamm, A; Sadeniemi, L

    1990-10-01

    A series of 143 subjects representing an Estonian urban population was examined for the occurrence and extent (absent, mild, moderate, severe) of Helicobacter pylori colonization in antral and body biopsy specimens (Giemsa staining). These data were correlated with the presence and grade of chronic gastritis (normal, mild, moderate, or severe superficial chronic gastritis; mild, moderate, or severe atrophic gastritis) in the antrum and the body. Gastritis of any grade was found in the antrum and/or the body in 140 (98%) subjects. The overall extent of H. pylori colonization in the whole series did not differ between the antrum and the body. Of 93 subjects with superficial gastritis, H. pylori was found in the antrum and/or the body in 87 (94%) cases. Of 47 subjects with atrophic gastritis in the antrum and/or the body. H. pylori was not found in 12 (25%). In subjects with gastritis the absence of H. pylori either in the antrum or in the body was relatively common (in 30 of 143 subjects). The grade of superficial gastritis showed a highly significantly positive correlation with the extent of H. pylori colonization in the antrum but not in the body. Correspondingly, the grade of atrophic gastritis in the antrum correlated negatively to the grade of colonization. The total absence of H. pylori was particularly associated with the absence of gastritis in the antrum. Conversely, severe body H. pylori colonization was found in subjects who had atrophic antral gastritis, and severe antral colonization in subjects who had at least moderate superficial antral gastritis and who showed a coexistent normal or slight superficial gastritis in the body.(ABSTRACT TRUNCATED AT 250 WORDS)

  5. Production of medical radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for cancer treatment and arterial restenosis therapy after PTCA

    International Nuclear Information System (INIS)

    Knapp, F.F. Jr.; Beets, A.L.; Mirzadeh, S.; Alexander, C.W.; Hobbs, R.L.

    1998-01-01

    The High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube (HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions (PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed

  6. Production of medical radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for cancer treatment and arterial restenosis therapy after PTCA

    Energy Technology Data Exchange (ETDEWEB)

    Knapp, F.F. Jr.; Beets, A.L.; Mirzadeh, S.; Alexander, C.W.; Hobbs, R.L.

    1998-06-01

    The High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube (HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions (PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed.

  7. Production of Medical Radioisotopes in the ORNL High Flux Isotope Reactor (HFIR) for Cancer Treatment and Arterial Restenosis Therapy after PTCA

    Science.gov (United States)

    Knapp, F. F. Jr.; Beets, A. L.; Mirzadeh, S.; Alexander, C. W.; Hobbs, R. L.

    1998-06-01

    The High Flux Isotope Reactor (HFIR) at the Oak Ridge National Laboratory (ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube (HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions (PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed.

  8. Ten-year trends in family medicine residency productivity and staffing: impact of electronic health records, resident duty hours, and the medical home.

    Science.gov (United States)

    Lesko, Sarah; Hughes, Lauren; Fitch, Wes; Pauwels, Judith

    2012-02-01

    Electronic health records (EHRs), resident duty hour restrictions, and Patient-centered Medical Home (PCMH) innovations have all impacted the clinical practices of residency programs over the past decade. The University of Washington Family Medicine Network (UWFMN) residencies have collaborated for 10 years in collecting and comparing data regarding the productivity and operations of their training programs to identify the program-level effects of such changes. Based on five survey results from 2000 to 2010, this study examines changes in faculty and resident productivity and staffing models of UWFMN residency training clinics using a standardized methodology, specifically describing the productivity impact of EHR changes and duty hour restrictions and the implementation of the PCMH by residencies. Data were systematically collected via standardized questionnaire, evaluated for quality, clarified, and then analyzed. Resident productivity decreased over the 10-year interval, with resident total yearly patient visits down 17.2%. Core family medicine faculty productivity was highly variable among programs, and nonphysician provider visits increased. Faculty part-time status increased. Front office, medical assistant, and nursing staffing grew significantly, but other administrative staff decreased, resulting in minimal change in total non-provider staffing. A majority of programs engaged in PCMH initiatives in 2010 and had implemented an EHR. Physician productivity in UWFMN residency programs decreased for all resident physicians from 2000 to 2010, likely due to a combination of decreased resident duty hours and other clinical practice changes. Productivity trends have implications for the structure and training requirements for family medicine residency programs.

  9. Production of medical radioisotopes in the ORNL high flux isotope reactor (HFIR) for cancer treatment and arterial restenosis therapy after PICA

    Science.gov (United States)

    Knapp, F. F.; Beets, A. L.; Mirzadeh, S.; Alexander, C. W.; Hobbs, R. L.

    1999-01-01

    The High Flux Isotope Reactor ( HFIR) at the Oak Ridge National Laboratory ( ORNL) represents an important resource for the production of a wide variety of medical radioisotopes. First beginning operation in 1965, the high thermal neutron flux (2.5×1015 neutrons/cm2/sec at 85 MW) and versatile target irradiation and handling facilities provide the opportunity for production of a wide variety of neutron-rich medical radioisotopes of current interest for therapy. In addition to serving as a key production site for californium-252 and other transuranic elements, important examples of therapeutic radioisotopes which are currently routinely produced in the HFIR for distribution include dysprosium-166 (parent of holmium-166), rhenium-186, tin-117 m and tungsten-188 (parent of rhenium-188). The nine hydraulic tube ( HT) positions in the central high flux region permit the insertion and removal of targets at any time during the operating cycle (22-24 days) and have traditionally represented a major site for production of medical radioisotopes. To increase the irradiation capabilities of the HFIR, special target holders have recently been designed and fabricated which will be installed in the six Peripheral Target Positions ( PTP), which are also located in the high flux region. These positions are only accessible during reactor refueling and will be used for long-term irradiations, such as required for the production of tin-117 m and tungsten-188. Each of the PTP tubes will be capable of housing a maximum of eight HT targets, thus increasing the total maximum number of HT targets from the current nine, to a total of 57. In this paper the therapeutic use of reactor-produced radioisotopes for bone pain palliation and vascular brachytherapy and the therapeutic medical radioisotope production capabilities of the ORNL HFIR are briefly discussed.

  10. Study of the physical and chemical properties of uranium intermetallics for novel medical irradiation targets for 99Mo production

    International Nuclear Information System (INIS)

    Moussa, Chantal

    2015-01-01

    This thesis is in the framework of the development of low 235 U enriched irradiation targets for the 99 Mo production, the mother isotope of 99m Tc, which is the main radioactive tracers used in nuclear medical imaging. The aim of this work is to identify a new material with a higher uranium density. To fulfil this objective, the determination of the phase relations has been considered for five ternary systems. The experimental work was the determination of the isothermal sections of the U-Al-X with X = Ti, Zr, Nb, Ga and Ge for two temperatures, for representative interactions with U in its orthorhombic form (aU) and cubic form (gU) respectively. The U-Nb-Al and U-Al-Ga ternary system were thermodynamically assessed by CALPHAD assessment. Subsequent characterizations have been carried out on the intermediate phases to determine their physical properties. These studies comprise their thermodynamic features (reaction of formation, including the reaction temperature and for some their enthalpy of formation), structural properties (by means of X-ray and electron diffractions) and their electronic properties, magnetic, and transport (electrical and thermal). This Ph-D thesis was extended to the study of ternary uranium germanides with the general formula U 3 TGe 5 by seeking for new isostructural compounds and to investigate their electronic properties. Nine new compounds have been identified with the transition metal, T = V, Cr, Mn, Zr, Nb, Mo, Hf, Ta and W with an anti-Hf 5 CuSn 3 structural type and various and complex behaviors, such as spin fluctuators, antiferromagnetic and ferromagnetic orders, emphasizing the predominant influence of the transition metal in these electronic phenomena. (author)

  11. How do initial signals of quality influence the diffusion of new medical products? The case of new cancer drug treatments.

    Science.gov (United States)

    Conti, Rena M; Bernstein, Arielle; Meltzer, David O

    2012-01-01

    Objective measures of a new treatment's expected ability to improve patients' health are presumed to be significant factors influencing physicians' treatment decisions. Physicians' behavior may also be influenced by their patients' disease severity and insurance reimbursement policies, firm promotional activities and public media reports. This chapter examines how objective evidence of the incremental effectiveness of novel drugs to treat cancer ("chemotherapies") impacts the rate at which physicians' adopt these treatments into practice, holding constant other factors. The novelty of the analysis resides in the dataset and estimation strategy employed. Data is derived from a United States population-based chemotherapy order entry system, IntrinsiQ Intellidose. Quality/price endogeneity is overcome by employing sample selection methods and an estimation strategy that exploits quality variation at the molecule-indication level. Pooled diffusion rates across molecule-indication pairs are estimated using nonparametric hazard models. Results suggest incremental effectiveness is negatively and nonsignificantly associated with the diffusion of new chemotherapies; faster rates of diffusion are positively and significantly related to low five-year survival probabilities and measures of perceived clinical significance. Results are robust to numerous specification checks, including a measure of alternative therapeutic availability. We discuss the magnitude and potential direction of bias introduced by several threats to internal validity. Evidence of incremental effectiveness does not appear to motivate the rate of specialty physician diffusion of new medical treatment; in all models high risk of disease mortality and perceptions of therapeutic quality are significant drivers of physician use of novel chemotherapies. Understanding the rate of technological advance across different clinical settings, as well as the product-, provider-, and patient-level determinants of this

  12. Impact of hypoglycemia on patients with type 2 diabetes mellitus and their quality of life, work productivity, and medication adherence

    Directory of Open Access Journals (Sweden)

    Lopez JMS

    2014-05-01

    Full Text Available Janice MS Lopez,1 Kathy Annunziata,2 Robert A Bailey,1 Marcia FT Rupnow,1 Donald E Morisky31Janssen Scientific Affairs, LLC, Raritan, NJ, 2Kantar Health, Princeton, NJ, 3University of California at Los Angeles Fielding School of Public Health, Los Angeles, CA, USABackground: The purpose of this study was to determine the characteristics of adults with type 2 diabetes mellitus (T2DM that correlate with greater risk of hypoglycemia and determine the impact of hypoglycemia on health-related quality of life, work productivity, and medication adherence from a patient perspective.Methods: Data from a large web-based survey were retrospectively analyzed. Adults with a diagnosis of T2DM taking antihyperglycemic agents were included in the analysis. Participants with knowledge of their hypoglycemic history were divided into three groups: those experiencing recent hypoglycemia (previous 3 months, those experiencing nonrecent hypoglycemia, and those never experiencing hypoglycemia.Results: Of the participants with T2DM taking antihyperglycemic agents who were knowledgeable of their hypoglycemia history, 55.7% had ever experienced hypoglycemia. Of those, 52.7% had recent hypoglycemia. Compared with those who never experienced hypoglycemia, those who experienced hypoglycemia tended to: be younger; be more aware of their glycated hemoglobin (HbA1c levels; have higher HbA1c levels; have a higher body mass index; have higher Charlson Comorbidity Index scores; be on insulin, sulfonylureas, and/or glucagon-like peptide-1 agonists; and be less adherent to their antihyperglycemic agents. Hypoglycemia interfered with social activities, caused more missed work (absenteeism, more impairment while at work (presenteeism, and decreased overall work productivity compared with patients who had never experienced hypoglycemia. Overall health-related quality of life, as determined by the Short Form-36 health questionnaire, was negatively impacted by hypoglycemia. Both

  13. Polychlorinated dibenzo-p-dioxin, dibenzofuran and biophenyl content in selected groups of Baltic herring and sprat from Estonian coastal waters in 2006.

    Directory of Open Access Journals (Sweden)

    Ott Roots

    2007-09-01

    Full Text Available The concentrations of polychlorinated dibenzo-p-dioxins (PCDDs, polychlorinated dibenzofurans (PCDFs and dioxin-like polychlorinated biphenyls (DL-PCB were determined in samples of Baltic herring (Clupea harengus membras and sprat (Sprattus sprattus balticus in 2006 from commercial catches in Estonian coastal waters, Baltic Sea. The dioxin content of the fish sampled in 2006 did not exceed the European Union's maximum permissible level for PCDD/Fs (4.0 pg WHO-TEQ/g fresh weight and for the sum of PCDD/Fs and DL-PCBs (8.0 pg WHO-TEQ/g fresh weight. PCDD/Fs and the sum of PCDD/Fs and DL-PCBs content in herring were 2.12 and 3.84 pg WHO-TEQ/g of fresh weight respectively; the corresponding figures for sprat were 1.94 and 3.82 pg WHO-TEQ/g of fresh weight. Comparable with our earlier data on the content of dioxins in three to four year old herring and two to three year old sprat, these data show that two servings of fish per week are not at all harmful tothe health of the Estonian people; indeed, the opposite is more likely to be the case.

  14. Biological dosimetric studies in the Chernobyl radiation accident, on populations living in the contaminated areas (Gomel regions) and in Estonian clean-up workers, using FISH technique

    International Nuclear Information System (INIS)

    Darroudi, F.; Natarajan, A.T.

    1996-01-01

    In order to perform retrospective estimations of radiation doses seven years after the nuclear accident in Chernobyl, the frequencies of chromosomal aberrations in the peripheral blood lymphocytes of individuals living in contaminated areas around Chernobyl and the Estonian clean-up workers were determined. The first study group composed of 45 individuals living in four areas (i.e. Rechitsa, Komsomolski, Choiniki and Zaspa) in the vicinity (80-125 km) of Chernobyl and 20 individuals living in Minsk (control group - 340 km from Chernobyl). The second study group (Estonian clean-up workers) composed of 26 individuals involved in cleaning up the Chernobyl for a different period of time (up to 7 months) and a matched control group consisting of 9 probands. Unstable aberrations (dicentrics and rings) were scored in Giemsa stained preparations and stable aberrations (translocations) were analyzed using chromosome specific DNA libraries and fluorescence in situ hybridization (FISH) technique. For both study groups the estimated average dose is between 0,1-0,4 Gy. Among the people living in the contaminated areas in the vicinity of Chernobyl, a higher frequency of numerical aberrations (i.e. trisomy, hyper diploidy) was evident

  15. Medical doctors profile in Ethiopia: production, attrition and retention. In memory of 100-years Ethiopian modern medicine & the new Ethiopian millennium.

    Science.gov (United States)

    Berhan, Yifru

    2008-01-01

    Although the practice of western medicine in Ethiopia dates back to the time of King Libne Dengel (1520-1535), organized and sustainable modern medical practice started after the battle of Adwa (1896). To review hospitals construction, medical doctors production and attrition, and to suggest alternative medical doctors retention mechanisms in the public sector and production scale up options. In this article, 100 years Ethiopian modern medical history is revised from old and recent medical chronicles. Until December 2006 primary data was collected from 87 public hospitals. Much emphasis is given to medical doctors profile (1906-2006), hospitals profile (1906-2005), medical doctors to population and hospitals ratio (1965-2006), Ethiopian public medical schools 42 years attainment (1964-2006), annual attrition rate (1984-2006), organizational structure of medical faculties & university hospitals, medical doctors remuneration by the Ministry of Health (MOH), Ministry of Education (MOE), NGOs and private health institutions. This article also addresses the way forward from physician training and retention perspectives, multiple alternate mechanisms to increase physicians' motivation to work in government institutions and reveres the loss. Medical doctors production scale up option is also given much emphasis. Most data are presented using line and bar graphs. Literature review showed that the first three hospitals were constructed in 1896 (Russian hospital), 1903 (Harar Ras Mekonnen hospital) and 1906 (Menelik II hospital). In 2005, 139 hospitals (87 public and 52 others) were reported. Remarkable hospital construction was done between 1935 and 1948, and recently between 1995 and 2005; however, in the latter case, private hospitals construction took the lions share. By the time MOH was established (1948), 110 Ethiopian and expatriate medical doctors were working, mainly in the capital, and 46 hospitals constructed. Physician number increment was very slow till 1980 at

  16. Avoiding pitfalls in the road from idea to certified product (and the harsh clinical environment thereafter) when innovating medical devices

    NARCIS (Netherlands)

    Wieringa, F.P.; Poley M.J.; Dumay, A.C.M.; Steen, A.F.W. van der

    2007-01-01

    Innovation in medical technology is a critical chain of events, ideally leading to an improved situation for patient and staff as well as a nice profit for the supplier of the innovation. Unfortunately many innovative ideas are not successful in practice. This is often due to lack of: • Medical

  17. Associations of ECP (eosinophil cationic protein-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study

    Directory of Open Access Journals (Sweden)

    Janson Christer

    2010-06-01

    Full Text Available Abstract Background The Eosinophil Cationic Protein (ECP is a potent multifunctional protein. Three common polymorphisms are present in the ECP gene, which determine the function and production of the protein. The aim was to study the relationship of these ECP gene polymorphisms to signs and symptoms of allergy and asthma in a community based cohort (The European Community Respiratory Health Survey (ECRHS. Methods Swedish and Estonian subjects (n = 757 were selected from the larger cohort of the ECRHS II study cohort. The prevalence of the gene polymorphisms ECP434(G>C (rs2073342, ECP562(G>C (rs2233860 and ECP c.-38(A>C (rs2233859 were analysed by DNA sequencing and/or real-time PCR and related to questionnaire-based information of allergy, asthma, smoking habits and to lung functions. Results Genotype prevalence showed both ethnic and gender differences. Close associations were found between the ECP434(G>C and ECP562(G>C genotypes and smoking habits, lung function and expression of allergic symptoms. Non-allergic asthma was associated with an increased prevalence of the ECP434GG genotype. The ECP c.-38(A>C genotypes were independently associated to the subject being atopic. Conclusion Our results show associations of symptoms of allergy and asthma to ECP-genotypes, but also to smoking habits. ECP may be involved in impairment of lung functions in disease. Gender, ethnicity and smoking habits are major confounders in the evaluations of genetic associations to allergy and asthma.

  18. Association between participation and compliance with Continuing Medical Education and care production by physicians: a cross-sectional study

    Science.gov (United States)

    Carrera, Renato Melli; Cendoroglo, Miguel; Gonçales, Paulo David Scatena; Marques, Flavio Rocha Brito; Sardenberg, Camila; Glezer, Milton; dos Santos, Oscar Fernando Pavão; Rizzo, Luiz Vicente; Lottenberg, Claudio Luiz; Schvartsman, Cláudio

    2015-01-01

    Objective Physician participation in Continuing Medical Education programs may be influenced by a number of factors. To evaluate the factors associated with compliance with the Continuing Medical Education requirements at a private hospital, we investigated whether physicians’ activity, measured by volumes of admissions and procedures, was associated with obtaining 40 Continuing Medical Education credits (40 hours of activities) in a 12-month cycle. Methods In an exclusive and non-mandatory Continuing Medical Education program, we collected physicians’ numbers of hospital admissions and numbers of surgical procedures performed. We also analyzed data on physicians’ time since graduation, age, and gender. Results A total of 3,809 credentialed, free-standing, private practice physicians were evaluated. Univariate analysis showed that the Continuing Medical Education requirements were more likely to be achieved by male physicians (odds ratio 1.251; p=0.009) and who had a higher number of hospital admissions (odds ratio 1.022; p<0.001). Multivariate analysis showed that age and number of hospital admissions were associated with achievement of the Continuing Medical Education requirements. Each hospital admission increased the chance of achieving the requirements by 0.4%. Among physicians who performed surgical procedures, multivariate analysis showed that male physicians were 1.3 time more likely to achieve the Continuing Medical Education requirements than female physicians. Each surgical procedure performed increased the chance of achieving the requirements by 1.4%. Conclusion The numbers of admissions and number of surgical procedures performed by physicians at our hospital were associated with the likelihood of meeting the Continuing Medical Education requirements. These findings help to shed new light on our Continuing Medical Education program. PMID:25807247

  19. [Determination and analysis of cost and production measures in physicians' practices and hospitals for the objective evaluation of medical measures].

    Science.gov (United States)

    Gessner, U; Horisberger, B

    1981-05-01

    The complete data on 7200 practising physicians in Switzerland were analyzed in the first phase of the project. The 2600 GP's and the 4600 specialists (in 18 medical specialties) were categorized as to year of graduation and geographic regions (population centres). The distributions of the practising physician of the different specialties over the population centres (defined by 30-min. catchment area) areas were evaluated. Trends towards specialization in larger settlement areas were analyzed. The results are being used as a basis for formation of samples for further studies. The inventories of medical technical equipment and medical procedures are in the process of systematization.

  20. Medical Applications

    OpenAIRE

    Biscari, C.; Falbo, L.

    2016-01-01

    The use of accelerators for medical applications has evolved from initial experimentation to turn-key devices commonly operating in hospitals. New applications are continuously being developed around the world, and the hadrontherapy facilities of the newest generation are placed at the frontier between industrial production and advanced R&D. An introduction to the different medical application accelerators is followed by a description of the hadrontherapy facilities, with special emphasis on ...