WorldWideScience

Sample records for esr age calculations

  1. The relevance of parametric U-uptake models in ESR age calculations

    International Nuclear Information System (INIS)

    Gruen, Rainer

    2009-01-01

    In the ESR dating three basic parametric U-uptake models have been applied for dating teeth: early U-uptake (EU: closed system), linear U-uptake (LU) and recent U-uptake (RU, it is assumed that the dose rate contribution of U in the dental tissues is zero). In many ESR dating publications it is still assumed that samples comply with one or the other parametric U-uptake model calculation or that their correct age lies somewhere between EU and LU. Observations of the spatial distribution of uranium in dental tissues show that it is difficult to predict any relationships between the relative uptake in the dental tissues. Combined U-series/ESR age estimates can give insights into the actual U-uptake. An evaluation of published data shows that for cave sites, a significant number of results fall outside the EU and LU bracket, while for open air sites, the majority of data are outside this bracket, particularly showing greatly delayed U-uptake. This may be due to changes in the hydrological system, leading to erosion which exposes the open air site. U-leaching has also been observed on samples from open air sites, in which case any reasonable age calculation is impossible.

  2. ESR and TL age determination of caliche nodules

    Energy Technology Data Exchange (ETDEWEB)

    Oezer, A.M. (Middle East Technical Univ., Ankara (Turkey)); Wieser, A.; Goeksu, H.Y.; Mueller, P.; Regulla, D.F. (Gesellschaft fuer Strahlen- und Umweltforschung mbH Muenchen, Neuherberg (Germany, F.R.). Inst. fuer Strahlenschutz); Erol, O. (Istanbul Univ. (Turkey). School of Geography and Marine Sciences)

    1989-01-01

    Feasibility of dating caliche nodules by ESR and TL is investigated. For both methods the properties of the dating signal are described. Chemical composition as well as TL glow curves of caliches originating from different localities exhibit some differences. Due to the complexity of the TL glow curves, some samples required a special post-annealing procedure in order to resolve the main TL peak for age determination. Typical ESR calcite signals do not exist in caliche, therefore usefulness of the g=2.0040 ESR signal is studied. The results of TL and ESR ages are found to be compatible except for two samples. Possible causes of the discrepancy in these samples are discussed. It is shown that, with proper treatment of the radiation-induced signals, it was possible to date caliche formations older than 350 ka, which is not achievable with other methods like uranium series disequilibrium and/or radiocarbon dating. (author).

  3. ESR and TL age determination of caliche nodules

    International Nuclear Information System (INIS)

    Oezer, A.M.; Wieser, A.; Goeksu, H.Y.; Mueller, P.; Regulla, D.F.; Erol, O.

    1989-01-01

    Feasibility of dating caliche nodules by ESR and TL is investigated. For both methods the properties of the dating signal are described. Chemical composition as well as TL glow curves of caliches originating from different localities exhibit some differences. Due to the complexity of the TL glow curves, some samples required a special post-annealing procedure in order to resolve the main TL peak for age determination. Typical ESR calcite signals do not exist in caliche, therefore usefulness of the g=2.0040 ESR signal is studied. The results of TL and ESR ages are found to be compatible except for two samples. Possible causes of the discrepancy in these samples are discussed. It is shown that, with proper treatment of the radiation-induced signals, it was possible to date caliche formations older than 350 ka, which is not achievable with other methods like uranium series disequilibrium and/or radiocarbon dating. (author)

  4. ESR dating method and the age determination of Peking-Man

    International Nuclear Information System (INIS)

    Jin Sizhao; Liang Renyou; Huang Peihua

    1991-01-01

    ESR dating method and the age determination of the first skull of Zhoukoudian Beijing-Man have been introduced in this paper. Some animal fossil teeth, which are contemporaneous with the Beijing-Man, were used for determination of accumulative dose. The internal and environmental doses of the tooth samples were determined by neutron activation analysis and embeded thermoluminescence dosimeter at the site, respectively. The age of 578 ka of the first skull of Beijing-Man is calculated by the linear uranium accumulation model. According to the ESR dating results, author has given a chronological scale of the cave deposits Loc. 1, Beijing-man site and discussed the mean-life of trapped electron for dating

  5. Calculation of the effective environmental dose rate for ESR and luminescence dating

    International Nuclear Information System (INIS)

    Brennan, B.J.

    2001-01-01

    The determination of the age of a sample using luminescence and ESR dating techniques requires knowledge of the sample's average effective environmental dose rate due to natural radiation sources (alpha, beta, gamma, and cosmic), and age estimates can never be more accurate than the estimate of this dose rate. The estimation process is often complicated by spatial and temporal inhomogeneities in the distribution of natural radiation sources. This paper discusses applications of radiation physics in modelling the effects of these inhomogeneities to ensure accurate estimation of the average dose rate for the sample. For natural alpha, beta, and gamma sources, 'dose point kernels' are employed in calculations using an assumed model for the spatial and temporal dependence of source concentrations. These three types of radiation have rather different penetration properties, with their typical effective ranges being multiples of 10 micrometre, 1 mm, and 100 mm respectively. For each type of radiation, applications are discussed where spatial inhomogeneity in the distribution of sources around and in a sample has a serious effect on the average dose rate to the sample. In some cases, (e.g. gamma dose estimation in 'lumpy' environments) lack of detailed knowledge precludes accurate modelling of the site for a particular sample, but useful statistical information can still be obtained. Temporal variation of radioactive source concentrations is usually coupled with spatial effects and can arise from processes such as parent-daughter disequilibrium, uptake or leaching of sources, or variation in burial depth or water saturation. Again, calculations based non a known or assumed history can be employed to obtain a time-averaged dose rate for a sample. The accuracy with which these calculations can reflect the true environmental dose rate is limited principally by the reliability of the model assumed, which in turn depends on the state of knowledge of the site and its history

  6. Attempt at ESR dating of tooth enamel of French middle pleistocene sites

    International Nuclear Information System (INIS)

    Bahain, J.J.; Sarcia, M.N.; Falgueres, C.; Yokoyama, Y.

    1993-01-01

    Tooth enamel samples from four important French middle Pleistocene sites are analyzed by the ESR method. ESR ages were calculated using uranium uptake mathematical models and compared with U-series results. (author)

  7. Quantifying the impact of µCT-scanning of human fossil teeth on ESR age results.

    Science.gov (United States)

    Duval, Mathieu; Martín-Francés, Laura

    2017-05-01

    Fossil human teeth are nowadays systematically CT-scanned by palaeoanthropologists prior to any further analysis. It has been recently demonstrated that this noninvasive technique has, in most cases, virtually no influence on ancient DNA preservation. However, it may have nevertheless an impact on other techniques, like Electron Spin Resonance (ESR) dating, by artificially ageing the apparent age of the sample. To evaluate this impact, we µCT-scanned several modern enamel fragments following the standard analytical procedures employed by the Dental Anthropology Group at CENIEH, Spain, and then performed ESR dose reconstruction for each of them. The results of our experiment demonstrate that the systematic high-resolution µCT-scanning of fossil hominin remains introduces a nonnegligible X-ray dose into the tooth enamel, equivalent to 15-30 Gy depending on the parameters used. This dose may be multiplied by a factor of ∼8 if no metallic filter is used. However, this dose estimate cannot be universally extrapolated to any µCT-scan experiment but has instead to be specifically assessed for each device and set of parameters employed. The impact on the ESR age results is directly dependent on the magnitude of the geological dose measured in fossil enamel but could potentially lead to an age overestimation up to 40% in case of Late Pleistocene samples, if not taken into consideration. © 2017 Wiley Periodicals, Inc.

  8. ESR Dosimetry

    International Nuclear Information System (INIS)

    Baffa, Oswaldo; Rossi, Bruno; Graeff, Carlos; Kinoshita, Angela; Chen Abrego, Felipe; Santos, Adevailton Bernardo dos

    2004-01-01

    ESR dosimetry is widely used for several applications such as dose assessment in accidents, medical applications and sterilization of food and other materials. In this work the dosimetric properties of natural and synthetic Hydroxyapatite, Alanine, and 2-Methylalanine are presented. Recent results on the use of a K-Band (24 GHz) ESR spectrometer in dosimetry are also presented

  9. Assessment of the lower ESR dating range in Greek speleothems

    International Nuclear Information System (INIS)

    Bassiakos, Y.

    2001-01-01

    Pilot ESR dating studies on geologically young calcitic sinters were carried out, aiming at assessment of the lower ESR dating range in characteristic Greek speleoenvironments. Five stalactites were dated, coming from an ancient mining gallery, idle for the last 2,500 years, found on Siphnos island (Aegean). The calculated ages range between 1,7-2,0 ka. Medium to low measured external dose rates (aprox. 900 μGy/a) and very low measured radioelement concentration in samples are very usual in the Mediterranean environments. The study concludes that ESR dating of speleothems younger than two millenia is practically unattainable. Some geoarchaeological implications of the obtained ages are discussed. (author)

  10. The effect of irradiation dose and age of bird on the ESR signal in irradiated chicken drumsticks

    International Nuclear Information System (INIS)

    Gray, R.; Stevenson, M.H.; Kilpatrick, D.J.

    1990-01-01

    Groups of 20 broiler chickens of the same genetic strain and reared under identical conditions were slaughtered at either 4, 5, 6, 7 or 8 weeks of age. Pairs of drumsticks were removed from each bird and groups were either not irradiated or irradiated at 2.5, 5.0, 7.5 or 10.0 kGy using a cobalt 60 source. Bone samples were excised, fragmented, freeze dried and ground prior to the determination of free radical concentration using electron spin resonance (ESR) spectroscopy. Increasing irradiation dose gave a highly significant increase in free radical concentration whilst for each irradiation dose, bones from younger birds gave significantly lower concentrations compared to those for older birds. Crystallinity coefficient increased linearly with age of bird and this may account in part for the increased signal observed as the birds aged. (author)

  11. The ESR age of Portlandia arctica shells from glacial deposits of Central Latvia . an answer to a controversy on the age and genesis of their enclosing sediments

    Science.gov (United States)

    Molodkov, Anatoly; Dreimanis, Aleksis; ĀBoltiņš, Ojars; Raukas, Anto

    The occurrence of Portlandia arctica shells in glacigenic sediments of Central Latvia had created a controversy in many publications about (1) their age ranging from the Holsteinian to the Late Weichselian and (2) the genesis of their enclosing sediments: glacial, glaciomarine or marine. Our reinvestigation of the main object of controversy, the Lı¯čupe site, leads to a conclusion that the sedimentary package of diamictons, clays and sands containing Portlandia arctica shells and marine microfossils is a large glacial raft that had been transported and deposited by the Riga lobe during the Weichselian. The electron spin resonance (ESR) ages on five sets of Portlandia arctica shells from the Lı¯čupe and Daugmales Tomēni sites range from 86.0±6.8 to 105.0±9.2 ka BP. These ESR age determinations and the cool climate indicators of the associated microflora and microfauna suggest that their source sediments, probably in the Gulf of Riga, are marine clays of Early Weichselian age, probably correlative to the Brørup Interstadial. In Central Latvia Portlandia arctica shells and their enclosing clay occur resedimented or translocated in glacial deposits during Weichselian glacial advances.

  12. Current topics in ESR dating

    International Nuclear Information System (INIS)

    Skinner, Anne R.

    2011-01-01

    After over 25 years, the use of electron spin resonance (ESR) is well-established in dating sites of geological, paleontological and archaeological interest. Like any scientific technique, there have been changes in understanding and in methodology. Improvements have not, however, changed the observation that external dose calculations are still a significant source of uncertainty in ages. Examples from Europe, Africa and the Americans illustrate this point. For Pradayrol Cave (France), the occupation age, 330 ka, is unchallenged, making this the oldest known Neanderthal site in France. For Roc de Marsal, also in France, on the other hand, discrepancies between TL and sedimentary dose rates imply substantial differences in interpretation. In the Western Egyptian Desert, where artifacts and datable material are not well-correlated, the dating results show consistency with expectations based on global climate change, even in deflated sites. Climate change is also the question in geological studies in the Bahamas where, despite concerns about cosmic dose history, ESR dates confirm other evidence for sea level changes. We show that an uncertain age is not the same as an impossible one.

  13. ESR dating of fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2002-03-01

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then trow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs grain size shows a plateau for grains below critical size : these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected from the Yangsan fault system. ESR dates from the this fault system range from 870 to 240 ka. Results of this research suggest that long-term cyclic fault activity continued into the pleistocene

  14. ESR dating of fault rocks

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee Kwon [Kangwon National Univ., Chuncheon (Korea, Republic of)

    2002-03-15

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then trow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs grain size shows a plateau for grains below critical size : these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected from the Yangsan fault system. ESR dates from the this fault system range from 870 to 240 ka. Results of this research suggest that long-term cyclic fault activity continued into the pleistocene.

  15. ESR dating studies on fossil of elaphurus davidianus horn

    International Nuclear Information System (INIS)

    Chen Shiming; Wang Hong; Tang Jingjuan; Yan Xiaomin; Guo Shiqing

    1991-01-01

    On the basis of studies on elephant tooth fossil, ESR dating of elaphurus davidianus horn fossil found in Anhui Province was reported. The sample examined by TEM electron spectrum is composed of hydroxyapatite. ESR experiments showed that the solid bone sample can be chosen as dating material. According to the contents of U, Th and K in the sample determined by ICP, the annual dose of radiation was calculated by using the linear uranium accumulation model and disequilibrium decay. The age of this fossil was determined to be 2.5 x 10 4 years

  16. ESR dating of fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2003-02-01

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then grow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs. grain size shows a plateau for grains below critical size; these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected near the Gori nuclear reactor. Most of the ESR signals of fault rocks collected from the basement are saturated. This indicates that the last movement of the faults had occurred before the Quaternary period. However, ESR dates from the Oyong fault zone range from 370 to 310 ka. Results of this research suggest that long-term cyclic fault activity of the Oyong fault zone continued into the Pleistocene

  17. ESR dating of fault rocks

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee Kwon [Kangwon National Univ., Chuncheon (Korea, Republic of)

    2003-02-15

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then grow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs. grain size shows a plateau for grains below critical size; these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected near the Gori nuclear reactor. Most of the ESR signals of fault rocks collected from the basement are saturated. This indicates that the last movement of the faults had occurred before the Quaternary period. However, ESR dates from the Oyong fault zone range from 370 to 310 ka. Results of this research suggest that long-term cyclic fault activity of the Oyong fault zone continued into the Pleistocene.

  18. Investigation and dating of gypsum crystals from Sivrihisar region in Eskisehir by ESR and TL techniques

    International Nuclear Information System (INIS)

    2011-01-01

    Gypsum crystals taken from Sivrihisar-Eskisehir district were investigated and dated by Electron Spin Resonance (ESR) and Thermoluminescence (TL) techniques. The natural ESR spectra of gypsum samples had also the signals of Mn 2 + in addition to the signal at g=2.009. It was observed that the intensity of ESR signal at g=2.009 increased with gamma irradiation dose. This ESR signal (g=2.009) was used as a dating signal in dating of gypsum samples. The only one TL peak at about 278 degree Celsius was observed in TL glow curves of nonirradiated gypsum sample. In the case of irradiated sample, TL peak at 157 degree Celsius was observed in addition of TL peak at 278 degree Celsius. Gypsum samples were irradiated with a 6 0Co gamma source. The ESR spectra and TL glow curve of gypsum samples were recorded by X-band ESR spectrometer and Risφ TL/OSL reader, respectively. For samples, ESR/TL dose-response curves was constructed. Dose-response curves were fitted with an exponential saturation function. Based on this model, accumulated dose (AD) values for dating are determined. 2 38U, 2 32Th and 4 0K analysis was carried out for gypsum crystals and dolomite which enveloped these gypsum crystals. The internal dose rate was calculated from 2 38U, 2 32Th and 4 0K analysis results of gypsum sample. The external dose rate was calculated by using 2 38U, 2 32Th and 4 0K analysis results of dolomite and cosmic dose rate. Internal and external gamma dose-rate was used for dating calculations. Because of successive recrystallization of gypsum sample after formation, calculated age values of gypsum is smaller than expected formation age.

  19. Combined ESR and U-series isochron dating of fossil tooth from Longgupo cave

    International Nuclear Information System (INIS)

    Han Fei; Yin Gongming; Liu Chunru; Jean-Jacques Bahain

    2012-01-01

    Background: In ESR and luminescence archaeological dating, the assessment of external radiation dose rate is one of the constant sources of uncertainty because of its variation in the past time and it cannot be determined accurately using the present-day measurements. Purpose: ESR isochron protocol was proposed to solve this uncertainty for the tooth samples. This protocol is applicable wherever multiple samples with different internal doses have all experienced a common external dose. The variable uranium concentration of tooth samples makes it possible to plot the equivalent dose versus the internal dose rate of each sample, and the slope of isochron line gives hence the age. For isochron dating of teeth, combined ESR/U-series dating analysis must be done together with isochron protocol. Methods: In this study, we try to use combined ESR/U-series isochron method on 5 tooth samples collected from immediate adjacent square in layer C Ⅲ'6 of Longgupo archaeological site, Chongqing, China. Combined ESR/U-series analysis with in situ external dose rate shows recent uranium uptake of all the samples. Results: The time-averaged external dose rate was iterative calculated by isochron protocol, and gives an isochron age of 1.77±0.09 Ma for layer C Ⅲ'6, which consistent with the mean US-ESR ages of 5 samples (1.64+0.16/-0.21 Ma) in the error range. The calculated time-averaged external dose rate(∼807 μGy/a) was basically in agreement with the in situ measured gamma dose rate value (8.50 μGy/a) in 2006, indicating the geochemical alterations may not occurred or do not affect the environmental dose rate obviously during the burial history. Conclusions: This study indicates the potential of solving both internal and external dose rate problems of ESR dating of fossil teeth by combining with U-series analysis and isochron protocol. (authors)

  20. ESR dating of tooth enamel samples

    International Nuclear Information System (INIS)

    Chen Tiemei; Yang quan; Wu En

    1993-01-01

    Five tooth samples from the palaeoanthropological site of Jinniushan were dated with both electron-spin-resonance (ESR) and uranium-series techniques. The ESR age of about 230 ka is in good agreement with the U-series dating result, which confirms the hypothesis of possible coexistence of Homo erect us and Homo sapiens in China. Problems in ESR dating are discussed such as: 1) inappropriate of simple exponential extrapolation for accumulated dose determination; 2)experimental measurement of alpha detection efficiency and radon emanation and 3)selection of U-uptake model

  1. ESR dating of the fault rocks

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Hee Kwon [Kangwon National Univ., Chuncheon (Korea, Republic of)

    2004-01-15

    Past movement on faults can be dated by measurement of the intensity of ESR signals in quartz. These signals are reset by local lattice deformation and local frictional heating on grain contacts at the time of fault movement. The ESR signals then grow back as a result of bombardment by ionizing radiation from surrounding rocks. The age is obtained from the ratio of the equivalent dose, needed to produce the observed signal, to the dose rate. Fine grains are more completely reset during faulting, and a plot of age vs, grain size shows a plateau for grains below critical size : these grains are presumed to have been completely zeroed by the last fault activity. We carried out ESR dating of fault rocks collected near the Ulzin nuclear reactor. ESR signals of quartz grains separated from fault rocks collected from the E-W trend fault are saturated. This indicates that the last movement of these faults had occurred before the quaternary period. ESR dates from the NW trend faults range from 300ka to 700ka. On the other hand, ESR date of the NS trend fault is about 50ka. Results of this research suggest that long-term cyclic fault activity near the Ulzin nuclear reactor continued into the pleistocene.

  2. ESR Dating Research of Glacial Tills in Tibetan Plateau

    Science.gov (United States)

    Bi, W.; Yi, C.

    2016-12-01

    In recent years, Quaternary Glacial-chronology has been made remarkable progress in the Tibetan Platean(TP) with the development of several numeric dating techniques, such as cosmogenic nuclides(NC), optically stimulated luminescence(OSL) and 14C. In constrast, the dating of Quaternary glacial tills in 100,000 years even more than million-year has been a challenge, just because the techniques has defects themselves and the sediments were stransformed during the geological and geomorphology progress later. Electron Spin Resonance(ESR) has been becoming one of the key methods of Quaternary Glacial-chronology with wide range of dating, expecially for the sample older than 100,000 years up to million-year scale. The accurate measurement of equivalent dose significantly impacts on accuracy and reliability of ESR dating method. Therefore, the study of the mechanisms of resetting processes is fundamental for accurate and reliable ESR dating. To understand the mechanism and characteristics of quartz ESR signal resetting of different samples, a series of laboratory simulation and field observation studies were carried out, which made lots of important breakthrough. But the research in quartz ESR signal of moraines is less and the test of ESR dating method is still in the qualitative investigation. Therefor, we use ESR dating and study on the mechanism and characteristics of quartz ESR signals in tills in the Tibetan Platean. In the adjust method of Modern, the quartz ESR signals in Modern glacial tills represent residual values which can be adjusted signals in the older glacial tills. As a consequence, ESR dating of the quartz in moraines needs to be explored in deep with building models to adjust ages which are measured by ESR dating. Therefore, ESR dating will become the trusted one of the cross dating methods in Quaternary Glacial-chronology with the adjust mothod improving the accuracy of ESR dating ages.

  3. A mechanical property and stress corrosion evaluation of VIM-ESR-VAR work strengthened and direct double aged Inconel 718 bar material

    Science.gov (United States)

    Montano, J. W.

    1986-01-01

    Presented are the mechanical properties and the stress corrosion resistance of triple melted vacuum induction melted (VIM), electro-slag remelted (ESR), and vacuum arc remelted (VAR), solution treated, work strengthened and direct double aged Inconel 718 alloy bars 4.00 in. (10.16) and 5.75 in. (14.60 cm) diameter. Tensile, charpy v-notched impact, and compact tension specimens were tested at ambient temperature in both the longitudinal and transverse directions. Longitudinal tensile and yield strengths in excess of 220 ksi (1516.85 MPa) and 200 ksi (1378.00 MPa) respectively, were realized at ambient temperature. Additional charpy impact and compact tension tests were performed at -100 F (-73 C). Longitudinal charpy impact strength equalled or exceeded 12.0 ft-lbs (16.3 Joules) at ambient and at -100 F(-73 C) while longitudinal compact (LC) tension fracture toughness strength remained above 79 ksi (86.80 MPa) at ambient and at -100 F(-73 C) temperatures. No failures occurred in the longitudinal or transverse tensile specimens stressed to 75 and 100 percent of their respective yield strengths and exposed to a salt fog environment for 180 days. Tensile tests performed after the stress corrosion test indicated no mechanical property degradation.

  4. Progress in ESR dating of fossils

    International Nuclear Information System (INIS)

    Ikeya, M.

    1983-01-01

    In this review the progress of ESR dating is briefly described together with its historical development. Examples of fossil dating include shells and corals in geological sediments, fossil bones and teeth in anthropology and fossil woods in geology. The total dose of natural radiation (TD) equivalent to the archaeological dose in TL dating was obtained by the additive dose method. Initially, the TDs were plotted against the known ages; using the apparent annual dose-rate thus obtained gives the ESR age within a factor of 2 or 3 for a fossil. Precise assessment of the radiation environment was made later taking the disequilibrium of uranium series disintegration into account. ESR ages of corals agreed well with those obtained by radiocarbon and uranium-thorium methods. The time-independent accumulation rate or a linear accumulation or uranium was adopted as a first sensible model for the opensystem fossil bones: the relation between the TD and the age explains the ages of anthropologically important bones. Lastly, geological assessment of fossil woods was made by ESR based on the organic radicals and electron traps in the silicified part. (author)

  5. Estimate of landslide deformation and failure time by ESR technique of. alpha. -quartz

    Energy Technology Data Exchange (ETDEWEB)

    Xingzhong, Liang; Mingdong, Chen [Chengdu Coll. of Geology, SC (China); Jiyong, Chen; Jiamin, Feng [Sichuan Univ., Chengdu, SC (China)

    1991-02-01

    ESR dating has been applied to study landslides. A method of dose-difference to determine the landslide age has been developed. The ESR spectra of annealled quartz grain samples and the optimum conditions of thermal activation were studied. The signifcance of ESR dating of landslide in geological research was discussed.

  6. ESR dating of laterite from Ban Tha Ta Suea, Kanchanaburi, Thailand

    International Nuclear Information System (INIS)

    Limsuwan, S.; Vichaidid, T.; Limsuwan, P.

    2011-01-01

    Electron spin resonance (ESR) dating was carried out on laterite samples collected from Ban Tha Ta Suea, the original deposit of the laterite used in the construction of Muang Sing Historical Park. Ban Tha Ta Suea is about 6 km east of Muang Sing Historical Park in Kanchanaburi province (181 km far from Bangkok). The dose response of the g=2.0028 ESR signal was found to be suitable for age determination. An exponential saturation function was fitted to the ESR signal growth on additional γ-irradiation. Extrapolation of this function resulted in the accumulated dose 144±5 Gy. Gamma spectroscopy and neutron activation analysis (NAA) were used to determine concentrations of 238 U, 232 Th and 40 K in the samples from which the annual dose rate 16±2 mGy was calculated. In addition, the dose rate of cosmic rays was taken into account. The ESR age of laterite samples was found to be 9.0±0.9 ka. This age falls within the Holocene epoch of the Quaternary on the geological time scale. Samples from Muang Sing Historical Park were assigned to the same epoch. Both results agree with the geological map.

  7. Influence of mass measurements at FSR-ESR on r-process calculations. Report on the work performed under contract ''4500047689 / 23.09.2004'' in the frame of the HGF Virtual Institute VH VI-061 ''Struktur der Kerne und Astrophysik (VISTARS)''

    International Nuclear Information System (INIS)

    Pfeiffer, B.

    2006-07-01

    The aim of the study is to examine the influence of direct mass measurements performed at the FRS-ESR of the GSI on the calculations of isotopic abundances in the astrophysical r-process. In addition, persepectives for measurements with the future Facility for Antiproton and Ion Research FAIR are shown. (orig.)

  8. Influence of mass measurements at FSR-ESR on r-process calculations. Report on the work performed under contract '4500047689 / 23.09.2004' in the frame of the HGF Virtual Institute VH VI-061 'Struktur der Kerne und Astrophysik (VISTARS)'

    Energy Technology Data Exchange (ETDEWEB)

    Pfeiffer, B.

    2006-07-15

    The aim of the study is to examine the influence of direct mass measurements performed at the FRS-ESR of the GSI on the calculations of isotopic abundances in the astrophysical r-process. In addition, persepectives for measurements with the future Facility for Antiproton and Ion Research FAIR are shown. (orig.)

  9. The MiAge Calculator: a DNA methylation-based mitotic age calculator of human tissue types.

    Science.gov (United States)

    Youn, Ahrim; Wang, Shuang

    2018-01-01

    Cell division is important in human aging and cancer. The estimation of the number of cell divisions (mitotic age) of a given tissue type in individuals is of great interest as it allows not only the study of biological aging (using a new molecular aging target) but also the stratification of prospective cancer risk. Here, we introduce the MiAge Calculator, a mitotic age calculator based on a novel statistical framework, the MiAge model. MiAge is designed to quantitatively estimate mitotic age (total number of lifetime cell divisions) of a tissue using the stochastic replication errors accumulated in the epigenetic inheritance process during cell divisions. With the MiAge model, the MiAge Calculator was built using the training data of DNA methylation measures of 4,020 tumor and adjacent normal tissue samples from eight TCGA cancer types and was tested using the testing data of DNA methylation measures of 2,221 tumor and adjacent normal tissue samples of five other TCGA cancer types. We showed that within each of the thirteen cancer types studied, the estimated mitotic age is universally accelerated in tumor tissues compared to adjacent normal tissues. Across the thirteen cancer types, we showed that worse cancer survivals are associated with more accelerated mitotic age in tumor tissues. Importantly, we demonstrated the utility of mitotic age by showing that the integration of mitotic age and clinical information leads to improved survival prediction in six out of the thirteen cancer types studied. The MiAge Calculator is available at http://www.columbia.edu/∼sw2206/softwares.htm .

  10. ESR dating a quaternary travertine

    International Nuclear Information System (INIS)

    Lopez Carranza, E.; Amosse, J.; Bouchez, R.

    1987-10-01

    To study the chronology of the quarternary glaciations in the high Peruvian Andes (3.5-4.0 Km high) a number of samples of travertines was collected in the Oroya-Tarma-Huancayo region. We report, in particular, the ESR measurements realized on samples from Santa Rosa de Sacco, which contain 99% of calcite and show a line of g=2.0046 and of width 8.3G, stable, at least, until ∼ 270 deg C. Using the additive dose method to obtain the paleodose and measuring the annual dose by spectrometry gamma of high resolution we obtain for the samples, as a preliminary result, an age between 260,000 and 340,000 a. (author). 7 refs, 6 figs

  11. ESR teleradiology survey: results.

    Science.gov (United States)

    2016-08-01

    With recent developments of teleradiology technology and services, it has become necessary to better evaluate its extent and use among different countries in Europe. With this goal in mind, the ESR launched two specific surveys intended to gather the current state of adoption and implementation of teleradiology in clinical practice. A special focus on differentiating between insourcing teleradiology services among partners of the same organisation and outsourcing to external services was an essential part of the design of these surveys. The first survey was addressed to 44 national societies of different countries in Europe, while the second survey was intended for all practicing radiologist ESR members. While the results of these surveys reported here may provide a wealth of information to better understand the trends in adoption of teleradiology in Europe, they only represent a snapshot at a certain point in time. The rapid development of telecommunication tools as well as a fundamental change in practice and healthcare economics will certainly influence these observations in the upcoming years. These data, however, will provide objective and relevant parameters for supporting the efforts of experts and policy makers in promoting appropriate criteria and guidelines for adequate use of teleradiology in clinical practice. Main Messages • Understand concepts and challenges of teleradiology • Provide insight into current trends and solutions for teleradiology • Compare differences in teleradiolgy strategies between countries in Europe • Establish a reference on statistical data of usage of teleradiology in Europe.

  12. ESR detection of irradiated seashells

    Energy Technology Data Exchange (ETDEWEB)

    Raffi, J. [Laboratoire de Recherche sur la Qualite des Aliments, Faculte de Saint-Jerome, Marseille (France); Hasbany, C. [Laboratoire de Recherche sur la Qualite des Aliments, Faculte de Saint-Jerome, Marseille (France)]|[Laboratoire de Chimie des Produits Naturels, Faculte de Saint-Jerome, Marseille (France); Lesgards, G. [Laboratoire de Chimie des Produits Naturels, Faculte de Saint-Jerome, Marseille (France); Ochin, D. [Institut Agricol et Alimentaire de Lille (France). Lab. de Microbiologie et d`Hygiene Alimentaire

    1996-11-01

    Among the protocols for identification of irradiated foodstuffs submitted to the European Committee of Standardization, two using ESR (food containing bone or cellulose) were finally accepted as official `draft European standards` in Berlin on 9-10 June 1994. We present here some new results for oyster and mussel shells, and an ESR draft protocol is proposed. (author).

  13. Study on identification of irradiated food containing cellulose by ESR

    International Nuclear Information System (INIS)

    Wan Xiaojuan; Dou Daying; Xu Gang; Jiao Zheng; Wang Jia; Zheng Jianfei; Jiao Zheng; Wu Minghong; Ding Guoji

    2008-01-01

    The fast development and application of food irradiation technology signify the necessity and urgency to research on effective detection method for irradiated food. In this paper, we report a preliminary study in this area with dried chili powder, peanuts and strawberry seeds. The food samples were irradiated to 0.5, 1.0, 3.0, 5.0 and 10.0 kGy by 60 Co gamma rays. The relation between ESR intensity and irradiation dose, and correlation R 2 , were studied. The results showed that the ESR signal intensity is positively related with the dose. ESR intensity of the strawberry increased the slowest with the dose, and the chili powder had the most accurate calculation. Accurate dose-effect curves, however, require repeating tests and further studies are needed to verify the ESR results. (authors)

  14. Analysis of radicals induced in irradiated cereal flour using ESR

    International Nuclear Information System (INIS)

    Kawamura, Shoei; Kishita, Keigo; Ukai, Mitsuko; Kikuchi, Masahiro; Kobayashi, Yasuhiko

    2013-01-01

    Using electron spin resonance (ESR) spectroscopy, we revealed radicals induced in cereal flour irradiated with gamma-ray or electron beam. Sample was wheat and rice. We detected a broad singlet signal at g = 2.0. It consists of a singlet signal and a triplet signal. It suggested that the singlet signal is originated from organic free radicals and the triplet signal is from 14 N. There were no differences of ESR spectra between irradiated wheat flour and rice flour. The signal intensity of radiation induced radical was tend to increase following with the increase of radiation dose level. After radiation treatment, relaxation time of radiation induced radical was changed during storage. T 1 was decreased and T 2 was increased. In this study, the relaxation time is calculated using the parameters obtained from the ESR signal. It is necessary to analyze the relaxation time directly with pulsed ESR spectroscopy in future. (author)

  15. ESR-dating of subfossil mollusc shells: the problem of absorbed paleodose fading

    International Nuclear Information System (INIS)

    Molod'kov, A.

    1988-01-01

    Detailed investigation of paleodosimetric prperties of subfossil mollusc shells has been carried out with respect to their dating by ESR-spectroscopy. Attention has been paid to the connection between the absorbed paleodose value and factors on the upper dating limit. Energetic parameters of the CO 3 3- centres have been determined in the calcareous shell skeleton serving as a paleodetector: E=1.515 eV, ν 0 =8x10 13 s -1 , τ=1.14x10 6 years at 5 deg C. Mathematical models have been elaborated for the accumulation of paleodose in natural conditions. New paleodosimetric equations proposed for calculating the age of shells and some minerals may be applied both to ESR- and thermoluminescence-dating. The proposed method enables one to date the shells within the time span of nx10 2 -nx10 6 years

  16. ESR identification of gamma-irradiated albendazole

    Science.gov (United States)

    Çolak, Seyda

    2010-01-01

    The use of ionizing radiation for sterilization of pharmaceuticals is a well-established technology. In the present work, the spectroscopic and kinetic features of the radicals induced in gamma-irradiated solid albendazole samples is investigated at different temperatures in the dose range of 3-34 kGy by electron spin resonance (ESR) spectroscopy. Irradiation with gamma radiation produced two different radical species in albendazole. They were fairly stable at room temperature but relatively unstable above room temperature, giving rise to an unresolved ESR spectrum consisting of three resonance peaks centered at g=2.0057. Decay activation energies of the contributing radical species were calculated to be 47.8 (±13.5) and 50.5 (±9.7) kJ/mol using the signal intensity decay data derived from annealing studies performed at high temperatures. A linear function of the applied dose was found to best describe the experimental dose-response data. Albendazole does not present the characteristics of good dosimetric materials. However, the discrimination of irradiated albendazole from its unirradiated form was possible even 6 months after storage in normal conditions. Based on these findings, it is concluded that albendazole and albendazole-containing drugs can be safely sterilized by gamma radiation and that ESR spectroscopy could be successfully used as a potential technique for monitoring their radiosterilization.

  17. The importance of pre-annealing treatment for ESR dating of mollusc shells: A key study for İsmil in Konya closed Basin/Turkey

    Science.gov (United States)

    Ekici, Gamze; Sayin, Ulku; Aydin, Hulya; Isik, Mesut; Kapan, Sevinc; Demir, Ahmet; Engin, Birol; Delikan, Arif; Orhan, Hukmu; Biyik, Recep; Ozmen, Ayhan

    2018-02-01

    In this study, Electron Spin Resonance (ESR) spectroscopy is used to determine the geological ages of fossil mollusc shells systematically collected from two different geological splitting at İsmil Location (37.72769° N, 33.17781° E) in eastern part of Konya. According to the assessment of obtained ESR ages, the importance of pre-annealing treatment emphasize in the case of g=2.0007 dating signal is overlapped with the other signals arisen from short lived radicals that cause the wrong age calculation. To overcome this problem, the samples are pre-annealed at 180°C for 16 minutes and, in this case ESR ages are re-calculated for g=1.9973 dating signal. Dose response curves are obtained using 1.9973 signals after pre-annealing treatments for each samples. ESR ages of samples are obtained in the range of 138 ± 38 ka and 132 ± 30 ka (Upper Pleistocene) according to the Early Uranium Uptake model and the results are in good agreement with the estimated ages from stratigraphic and paleontological correlation by geologists. Thus, it is suggested that especially in the case of 2.0007 dating signal cannot been used due to superimposition case, the signal with 1.9973 g value can be used for dating after pre-annealing treatment. The results reports the first ESR ages on shells collected from İsmil Location and highlight the importance of pre-annealing treatment. This study is supported by TUBITAK 114Y237 research project.

  18. Evaluation of flux-trapping and magneto-resistibility of superconductors by ESR spectroscopy; ESR ho ni yoru chodendotai no jisoku hosoku to taijiba tokusei no hyoka

    Energy Technology Data Exchange (ETDEWEB)

    Kusumori, T; Matsuura, K; Muto, H [National Industrial Research Institute of Nagoya, Nagoya (Japan)

    1995-09-28

    The abnormal sisal, which was observed in the ESR measurement of superconductors, was confirmed to be a non-ESR (non resonant) signal, from an ESR experiment applying parallel and vertically polarized microwave fields and from the calculation of the ESR transition probabilities. The field modulation dependence of the spectra revealed that the signal was composed of two components. From the modulation-scheme analysis and a study of type I and II superconductors, two components were assigned to the microwave responses to magnetizations trapped in the crystalline portion and at intergranular Josephson junctions. The former B and the batter J components are observed in the first derivative and absorption a form, respectively, and their polarities differently behave for the field sweep reversal. Based on these results, we have improved an ESR spectrometer, which makes it possible to measure separately two kinds of magnetization and to study the trapping ability and quantum flux. 11 refs., 12 figs., 1 tab.

  19. ESR signals of irradiated insects

    International Nuclear Information System (INIS)

    Ukai, Mitsuko; Kameya, Hiromi; Imamura, Taro; Miyanoshita, Akihiro; Todoriki, Setsuko; Shimoyama, Yuhei

    2009-01-01

    Analysis of irradiated insects using Electron Spin Resonance (ESR) spectroscopy was reported. The insects were maize weevil, red flour beetle, Indian meal moth and cigarette beetle that are hazardous to crops. The ESR spectra were consisted of a singlet at g=2 and a sextet centered at the similar g-value. The singlet signal is due to an organic free radical. The sextet signal is attributable to the hyperfine interactions from Mn 2+ ions. Upon irradiation, new signals were not detected. The relaxation times, T 1 and T 2 , showed no variations before and after irradiation. (author)

  20. Time-resolved ESR spectroscopy

    International Nuclear Information System (INIS)

    Beckert, D.

    1986-06-01

    The time-resolved ESR spectroscopy is one of the modern methods in radiospectroscopy and plays an important role in solving various problems in chemistry and biology. Proceeding from the basic ideas of time-resolved ESR spectroscopy the experimental equipment is described generally including the equipment developed at the Central Institute of Isotope and Radiation Research. The experimental methods applied to the investigation of effects of chemically induced magnetic polarization of electrons and to kinetic studies of free radicals in polymer systems are presented. The theory of radical pair mechanism is discussed and theoretical expressions are summarized in a computer code to compute the theoretical polarization for each pair of the radicals

  1. Elevated seminal plasma estradiol and epigenetic inactivation of ESR1 and ESR2 is associated with CP/CPPS.

    Science.gov (United States)

    Nesheim, Nils; Ellem, Stuart; Dansranjavin, Temuujin; Hagenkötter, Christina; Berg, Elena; Schambeck, Rupert; Schuppe, Hans-Christian; Pilatz, Adrian; Risbridger, Gail; Weidner, Wolfgang; Wagenlehner, Florian; Schagdarsurengin, Undraga

    2018-04-13

    Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is associated with urinary tract symptoms and hormonal imbalances amongst others. The heterogeneous clinical presentation, unexplored molecular background and lack of prostate biopsies complicate therapy. Here, using liquid biopsies, we performed a comprehensive translational study on men diagnosed with CP/CPPS type III ( n = 50; median age 39.8, range 23-65) and age-matched controls ( n = 61; median age 36.8, range 20-69), considering biochemical parameters of blood and ejaculates, and epigenetic regulation of the estrogen receptor genes ( ESR1 and ESR2 ) in leukocytes isolated from blood (systemic regulation) and in somatic cells isolated from ejaculates (local regulation). We found elevated 17β-estradiol (E 2 ) levels in seminal plasma, but not in blood plasma, that was significantly associated with CP/CPPS and impaired urinary tract symptoms. In ejaculated somatic cells of CP/CPPS patients we found that ESR1 and ESR2 were both significantly higher methylated in CpG-promoters and expressionally down-regulated in comparison to controls. Mast cells are reported to contribute to CP/CPPS and are estrogen responsive. Consistent with this, we found that E 2 -treatment of human mast cell lines (HMC-1 and LAD2) resulted in altered cytokine and chemokine expression. Interestingly, in HMC-1 cells, possessing epigenetically inactivated ESR1 and ESR2, E 2 -treatment led to a reduced transcription of a number of inflammatory genes. Overall, these data suggest that elevated local E 2 levels associate with an epigenetic down-regulation of the estrogen receptors and have a prominent role in CP/CPPS. Investigating E 2 levels in semen could therefore serve as a promising biomarker to select patients for estrogen targeted therapy.

  2. The Evaluation of IL6 and ESR1 Gene Polymorphisms in Primary Dysmenorrhea.

    Science.gov (United States)

    Ozsoy, Asker Zeki; Karakus, Nevin; Yigit, Serbulent; Cakmak, Bulent; Nacar, Mehmet Can; Yılmaz Dogru, Hatice

    2016-01-01

    Primary dysmenorrhea is the most common gynecological complaint with painful menstrual cramps in pelvis without any pathology. It affects about half of menstruating women, and it causes significant disruption in quality of life. We investigated the association between IL6 gene promoter and ESR1 gene XbaI and PvuII polymorphisms and primary dysmenorrhea. In this case-control study, 152 unrelated young women with primary dysmenorrhea and 150 unrelated healthy age-matched controls participated. Genomic DNA was isolated and IL6 and ESR1 gene polymorphisms were genotyped using PCR-based RFLP assay. The distribution of genotype and allele frequencies of IL6 gene promoter and ESR1 gene XbaI polymorphisms were not statistically different between patients and controls (p > 0.05). However, the genotype and allele frequencies of ESR1 gene PvuII polymorphism showed statistically significant differences between primary dysmenorrhea patients and controls (p = 0.009 and p = 0.021, respectively). Statistically significant associations were also observed between age and married status of primary dysmenorrhea patients and ESR1 gene PvuII polymorphism (p = 0.044 and p = 0.023, respectively). In combined genotype analyses, AG at ESR1 XbaI and TC at ESR1 PvuII loci encoded a p-value of 0.027. Thus, individuals who are heterozygote at both loci have a lower risk of developing primary dysmenorrhea. Our study suggests no strong association between IL6 gene promoter and ESR1 gene XbaI polymorphisms and primary dysmenorrhea in Turkish women. However, ESR1 gene PvuII polymorphism showed statistically significant differences between primary dysmenorrhea patients and controls. The potential association between ESR1 gene PvuII polymorphism and age and married status of dysmenorrhea patients deserves further consideration.

  3. Computer enhancement of ESR spectra of magnetite nanoparticles

    Energy Technology Data Exchange (ETDEWEB)

    Dobosz, B.; Krzyminiewski, R. [Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan (Poland); Koralewski, M. [Optics Laboratory, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan (Poland); Hałupka-Bryl, M. [Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznan (Poland); The PhD Program in Nanoscience and Nanotechnology, The Nanobiomedical Centre, Umultowska 85, 61-614 Poznan (Poland)

    2016-06-01

    We present ESR measurements of non-interacting magnetic nanoparticle systems. Temperature and orientational dependence of ESR spectra were measured for Fe{sub 3}O{sub 4} nanoparticle coated by dextran or oleic acid, frozen in different magnetic field. Several parameters describing magnetic properties such as g-factor, line width, the anisotropy constant were calculated and discussed. The ESR spectra of investigated nanoparticles were also subjected to Computer Resolution Enhancement Method (CREM). This procedure allows to separate a narrow line on the background of the broad line, which presence in this type of materials was recognized in the recent literature and have been further discussed in the paper. CREM is a valuable tool for monitoring of changes on the surface of magnetic core of nanoparticles. - Highlights: • CREM – a new tool for monitoring of changes on the surface of magnetic core of nanoparticles. • CREM allows to separate a narrow line on the background of the broad line. • Temperature and orientational dependence of ESR spectra of Fe{sub 3}O{sub 4} nanoparticles were measured. • Parameters describing magnetic properties were calculated and discussed.

  4. Investigation of radiosterilization feasibility of sulfamethoxazole by ESR spectroscopy

    Science.gov (United States)

    Çolak, Şeyda

    2017-12-01

    In the present study, the spectroscopic features of the radiolytic intermediates that were produced in gamma-irradiated (5, 10, 25 and 50 kGy) sulfamethoxazole (SMX) have been investigated by electron spin resonance (ESR) spectroscopy and the radiation sterilization feasibility of SMX by ionizing radiation was examined. Gamma-irradiated SMX exhibited a complex ESR spectrum consisting of 13 resonance lines where spectral parameters for the central resonance line were found to be g = 2.0062 and ΔHpp = 0.6 mT. The radiation yield of SMX was calculated to be relatively low (G = 0.1) by ESR spectroscopy and no meaningful difference was observed in the comparison of unirradiated and 50 kGy gamma irradiated SMX by the Fourier transform infrared (FT-IR) technique, confirming that SMX is a radioresistive material. Although SMX could not be accepted to be a good dosimetric material, the identification of irradiated SMX from the unirradiated sample was possible even for the low absorbed radiation doses and for a relatively long time (three months) after the irradiation process. Decay activation energy of the radical species, which is mostly responsible for the central intense resonance line, is calculated to be 45.15 kJ/mol by using the signal intensity decay data derived from annealing studies. Four radical species with different spectroscopic properties were accepted to be responsible for the ESR spectra of gamma-irradiated SMX, by simulation calculations. It is concluded that SMX and SMX-containing drugs can be sterilized by gamma radiation and ESR spectroscopy is an appropriate technique for the characterization of these induced radical intermediates during the gamma irradiation process of SMX. Toxicology tests should also be done for its safe usage.

  5. Total deposition of inhaled particles related to age: comparison with age-dependent model calculations

    International Nuclear Information System (INIS)

    Becquemin, M.H.; Bouchikhi, A.; Yu, C.P.; Roy, M.

    1991-01-01

    To compare experimental data with age-dependent model calculations, total airway deposition of polystyrene aerosols (1, 2.05 and 2.8 μm aerodynamic diameter) was measured in ten adults, twenty children aged 12 to 15 years, ten children aged 8 to 12, and eleven under 8 years old. Ventilation was controlled, and breathing patterns were appropriate for each age, either at rest or at light exercise. Individually, deposition percentages increased with particle size and also from rest to exercise, except in children under 12 years, in whom they decreased from 20-21.5 to 14-14.5 for 1 μm particles and from 36.8-36.9 to 32.2-33.1 for 2.05 μm particles. Comparisons with the age-dependent model showed that, at rest, the observed data concerning children agreed with those predicted and were close to the adults' values, when the latter were higher than predicted. At exercise, child data were lower than predicted and lower than adult experimental data, when the latter agreed fairly well with the model. (author)

  6. Determination of alpha effectiveness in ESR dating using nuclear accelerator techniques: methods and energy dependence

    International Nuclear Information System (INIS)

    Lyons, R.G.

    1988-01-01

    An important parameter in calculating the environmental dose rate for electron spin resonance (ESR) age estimates is the relative effectiveness of alpha and gamma radiation. A small research accelerator is used as a source of alpha particles of various pre-selected energies, corresponding to those found in the environment, to determine the effectiveness of alpha radiation of different energies. Preparation of sample targets is discussed, including the use of absolute ethanol, thorough etching and deposition by centrifuge. Preliminary results show that the alpha/gamma effectiveness ratio, k, depends on the energy of the incident alpha and must therefore be expressed in terms of a reference energy. The effectiveness of an alpha particle in causing ESR damage is found to vary linearly with its range or path length, not with its energy, a fact which must be considered when calculating effective dose-rates from environmental radionuclide concentrations. Failure to do so may lead to serious systematic errors in the effective alpha contribution to environmental dose-rates and consequently in age estimates. (author)

  7. Cooling history of the Valles Caldera, New Mexico using ESR dating method

    International Nuclear Information System (INIS)

    Ogoh, K.; Toyoda, S.; Ikeda, S.; Ikeya, M.; Goff, F.

    1993-01-01

    ESR dating was made at the Valles caldera by using the Al center and Ti center in quartz grains separated from the layers of the Valles Rhyolite. Obtained ESR ages were much younger than those by other methods (fission track and 39 Ar- 40 Ar). A reported thermal event of about 10-40 ka ago might explain the difference between the above ages. (author)

  8. ESR identification of irradiated foodstuffs

    International Nuclear Information System (INIS)

    Raffi, J.

    1993-01-01

    The conditions required to use Electron Spin Resonance (ESR) in identification of irradiated foods is first described. Then we present the results of an intercomparison sponsored by the Community Bureau of Reference involving 22 european laboratories. Qualitative identification of irradiated beef bones, dried grapes and papaya is very easy. Kinetical studies are necessary in case of fish species. Further researches are required in case of pistachio-nuts. Although all laboratories could distinguish between the two dose ranges used in case of meat bones (i.e. 1-3 and 7-10 kGy), there is an overlap of the results from the different laboratories. 2 tabs., 3 figs

  9. Comparative Study of Erythrocyte Sedimentation Rate (ESR) Using ...

    African Journals Online (AJOL)

    MICHAEL

    significant difference between the ESR values obtained using trisodium citrate and whole blood (P< 0.05). Males had lower ESR ... The ESR is governed by the balance between pro- ... 1999). When an inflammatory process is present, the.

  10. The ESR dating of the Nanjing Homo erectus stratigraphy

    International Nuclear Information System (INIS)

    Chen Tiemei; Wu En; Yang Quan; Hu Yanqiu

    1997-01-01

    Five fossil tooth enamel samples collected from the stratum of the Nanjing Homo erectus were ESR dated. The average age is 355 +- 42 ka, based on the early uranium-uptake model. Additional uranium series measurement of fossil teeth confirms the appropriateness of the early uranium-uptake model for these ESR samples. Considering also the uranium-series ages of two calcite samples from the flow stone covering the fossil-containing stratum, an age value of 350 +- 50 ka for the Nanjing Homo erectus stratum is evaluated, which means that the Nanjing Homo erectus appeared in the late stage of Peking Man and also in the stage of human evolution earlier than Hexian Homo erectus

  11. ESR as a method for the characterization of alluvial sediments

    International Nuclear Information System (INIS)

    Tissoux, H.; Voinchet, P.; Lacquement, F.; Despriée, J.

    2015-01-01

    The possibility of using the parameters involved in the ESR dating of optically bleached quartz grains in a purpose of source determination was checked. In that aim, samples previously taken in different sedimentary formations of the Middle Loire Basin (Central France) and dated by ESR have been observed. First discrimination was made using the thorium and potassium content in the sediments obtained by gamma spectrometry. The plot of these 119 data on the Th/K Schlumberger diagram clearly demonstrated that it was possible to discriminate the clays associations included in the sediment from which the dated quartz are extracted. Clay's nature could then be indicative of the geological nature of the substratum of rivers from their sources. Second discrimination was made using the ESR intensities calculated from Al, Ti–H and Ti–Li paramagnetic centres on 18 samples. It appears that the combination of the non-bleachable aluminum trap (DAT) saturation intensity and the Ti–H/Ti–Li ratio intensities make possible the discrimination of the two main sources of the sediment: Massif Central and Paris Basin. More deeply, The Ti/OBAT (Optically bleachable aluminum traps) intensities made possible the discrimination of quartz grains of different geological sources or with different geothermal history within the Massif Central group. - Highlights: • We used ESR and gamma spectrometry for source determination of alluvial quartz grains. • Th/K ratio distinguishes sediments from rivers flowing in various geological contexts. • Al, Ti–H and Ti–Li ESR centers discriminate quartz of different geological sources.

  12. ESR spectroscopic investigations of the radiation-grafting of fluoropolymers

    Energy Technology Data Exchange (ETDEWEB)

    Huebner, G; Roduner, E [University of Stuttgart (Germany); Brack, H P; Scherer, G G [Paul Scherrer Inst. (PSI), Villigen (Switzerland)

    1999-08-01

    ESR spectroscopic investigations have clarified the influence of several preparative parameters on the reaction rates and yields obtained in the radiation-grafting method used at PSI to prepare proton-conducting polymer membranes. At a given irradiation dose, a higher concentration of reactive radical sites was detected in ETFE films than in FEP films. This higher concentration explains the higher grafting levels and rates of the ETFE films found in our previous grafting experiments. Taken together, the in-situ ESR experiments and grafting experiments show that the rates of disappearance of radical species and grafting rates and final grafting levels depend strongly on the reaction temperature and the oxygen content of the system. Average grafted chain lengths were calculated to contain about 1,000 monomer units. (author) 2 figs., 4 refs.

  13. Combining wrist age and third molars in forensic age estimation: how to calculate the joint age estimate and its error rate in age diagnostics.

    Science.gov (United States)

    Gelbrich, Bianca; Frerking, Carolin; Weiss, Sandra; Schwerdt, Sebastian; Stellzig-Eisenhauer, Angelika; Tausche, Eve; Gelbrich, Götz

    2015-01-01

    Forensic age estimation in living adolescents is based on several methods, e.g. the assessment of skeletal and dental maturation. Combination of several methods is mandatory, since age estimates from a single method are too imprecise due to biological variability. The correlation of the errors of the methods being combined must be known to calculate the precision of combined age estimates. To examine the correlation of the errors of the hand and the third molar method and to demonstrate how to calculate the combined age estimate. Clinical routine radiographs of the hand and dental panoramic images of 383 patients (aged 7.8-19.1 years, 56% female) were assessed. Lack of correlation (r = -0.024, 95% CI = -0.124 to + 0.076, p = 0.64) allows calculating the combined age estimate as the weighted average of the estimates from hand bones and third molars. Combination improved the standard deviations of errors (hand = 0.97, teeth = 1.35 years) to 0.79 years. Uncorrelated errors of the age estimates obtained from both methods allow straightforward determination of the common estimate and its variance. This is also possible when reference data for the hand and the third molar method are established independently from each other, using different samples.

  14. Dose determination in irradiated chicken meat by ESR method

    International Nuclear Information System (INIS)

    Polat, M.

    1996-01-01

    signal intensity observed over 330 K was found to have an irreversible character. At the end ot five months study, it was found that CO-Zradicals produced in chicken bone were very stable and therefore it was concluded that chicken bone can be used as a dosimetry material. At the end of this work, a simulation procedure has been carried out for irradiated chicken bone ESR spectra to determine the spectral parameters of CO-Z ionic radical. The values obtained for these parameters were found to be in a good agreement with those found in the literature for the same radical. Many samples were irradiated at the same dose level and the ESR spectra were recorded to calculate the errors due to the settlement of the samples in the spectrometer and to the adjustment of the spectrometer. The standard deviations for measured signal intensities were calculated to determine the reliability limits of the numerical results obtained in this work for chicken bone

  15. [Identification of irradiated abalone by ESR spectroscopy].

    Science.gov (United States)

    Song, Yeping; Wang, Chuanxian; Yang, Zhenyu; Zhong, Weike; Geng, Jinpei; Lu, Di; Ding, Zhuoping

    2012-05-01

    To establish an analytical method for the detection and identification of irradiated abalone by electron spin resonance spectroscopy. Electron spin resonance (ESR) was used to study the spectral characteristics of abalone and the characteristic peak for quantitation. There were obvious different ESR spectra between unirradiated and irradiated abalone. The g factor for unirradiated abalone was 2.0055-2.0060, the g1 and g2 factor for irradiated abalone were (2.0027 +/- 0.0001) and (1.9994 +/- 0.0001), respectively. The ESR signal intensity of characteristic peak was positively correlated with absorbed dose in the range of 0.5 - 10 kGy, left peak was the characteristic peak for quantitation and the detection limit was abalone. ESR spectroscopy is an effective method to determine whether the abalone being irradiated or not.

  16. High Energy Electron Dosimetry by Alanine/ESR Spectroscopy

    International Nuclear Information System (INIS)

    Chu, Sung Sil

    1989-01-01

    Dosimetry based on electron spin resonance(ESR) analysis of radiation induced free radicals in amino acids is relevant to biological dosimetry applications. Alanine detectors are without walls and are tissue equivalent. Therefore, alanine ESR dosimetry looks promising for use in the therapy level. The dose range of the alanine/ESR dosimetry system can be extended down to l Gy. In a water phantom the absorbed dose of electrons generated by a medical linear accelerator of different initial energies (6-21 MeV) and therapeutic dose levels(1-60 Gy) was measured. Furthermore, depth dose measurements carried out with alanine dosimeters were compared with ionization chamber measurements. As the results, the measured absorbed doses for shallow depth of initial electron energies above 15 MeV were higher by 2-5% than those calculated by nominal energy CE factors. This seems to be caused by low energy scattered beams generated from the scattering foil and electron cones of beam projecting device in medical linear accelerator

  17. An ESR study on biological dosimeters: Human hair

    International Nuclear Information System (INIS)

    Colak, Seyda; Ozbey, Turan

    2011-01-01

    In the present work, characteristic features of the radicals found in untreated, gamma and UV-irradiated and mechanical damaged human hair samples were investigated by ESR spectroscopy. Heights of the resonance peaks measured with respect to the spectrum base line were used to monitor microwave power, dose-response, storage time and temperature dependent kinetic features of the radical species contributing to the formation of recorded experimental ESR spectra. Peak heights and g-values (2.0037-2.0052) determined from recorded spectra of hair were color dependent with ΔHpp-0.47 mT. The act of cutting hair samples gene rates sulfur centered radicals which are found in the a-keratin structure of hair. The variations of the peak heights with temperature were related with the water content found in the hair samples. In the 6-1100 Gy dose range, a linear + quadratic dose-response curve was recorded for hair and the mean radiation yield (G mean ) was calculated to be 0.4. The gamma radiation induced radicals were stable for a several hours at room temperature storage conditions. Based on these findings it was concluded that human hair samples could be used as biological/personnel dosimeters and that ESR spectroscopy could be successfully used as a potential technique for monitoring its dosimetric behaviours.

  18. The ESR dating of fossil enamel samples from palaeo-anthropological and Palaeolithic sites of Early Pleistocene

    International Nuclear Information System (INIS)

    Chen Qi; Chen Tiemei; Li Jiuqiang

    1999-01-01

    The following problems regarding the ESR dating of fossil enamel samples from palaeo-anthropological and Palaeolithic sites of Early Pleistocene are discussed: 1) the applicability of exponential fitting in the additive method for reliable AD determination; 2) the thermo-stability of the g = 2.0018 line of hydroxyapatite and its influence on apparent ESR ages; 3) the right selection of U-uptake models; and 4) the effect of high U-content in enamel on the ESR ages. It is concluded that the ESR-EU ages of Early Pleistocene enamel samples can only be regarded as the lower limit of the true ages if no appropriate corrections for the factors discussed above are made

  19. Dating of aragonite and dolomite from Devil's cave - SP, by dosimetric thermoluminescent method (DTL) and ESR

    International Nuclear Information System (INIS)

    Tatumi, S.H.

    1987-01-01

    We have investigated TL (Thermoluminescence) and ESR (electron spin resonance) properties of aragonite and dolomite found at ''Caverna do Diabo (Devil's cave)'' in the state of Sao Paulo to determine the ages of these geological materials. The aragonite, which is not a thermoluminescent material, shows one ESR signal whit g = 2.003. We obtained the age of 1.1 x 10 5 years and the growth rate of 1 μ m/year by the sample calibration with additional Y irradiation. The dolomite gives a TL glow curve with three distinct peaks at 261, 334 and 395 0 C. We found that the fit for the TL glow curve to second-order kinetics can be considerered as very acceptable. Using the second TL peak we obtained the age of 9.4 x 10 5 years and the compatible values of the activation energy (1.90 ± 0,07 eV) by the following methods: Hyperbolic heating, isothermal decay and fractional glow technique. We observed many ESR absorption signals in the dolomite. Three principal signal com g = 2.002, 2.003 and 2.005 were studied. We found that the first and second ESR signals were atributed to the CO 2 - and/or CO 3 3- centers and the last to the CO 3 - centers, and observed that the first ESR signal might related with the second TL peak and the TL sensitivity were associated with the concentration of Mn 2+ [pt

  20. ESR identification of irradiated foodstuffs: LARQUA research

    International Nuclear Information System (INIS)

    Raffi, J.

    1996-01-01

    As electron spin resonance (ESR) spectroscopy is the leading method for identification of irradiated foodstuffs, meat and fish bones, fruit and relative products (of vegetable origin), sea-food etc. were studied. In order to prepare a large co-trial on ESR identification of irradiation of irradiated foodstuffs, experiments were carried out at LARQUA, especially on fruits and vegetables. The radicals induced in the fruit pulp are not stable because the water content of fruit is generally high, but ESR can be used with dried fruit or dry components such as achenes, pips or stones. Different responses are observed, depending on the fruit. In ''sugatype'' fruits (papaya, dried grapes), an ESR multicomponent signal is radio-induced, but the non-irradiated fruit presents no ESR signal or a single-line, while in ''cellulose type'' fruits (pistachio nut, berries), a triplet is induced. But a six line signal due to Mn 2+ and a central single line may also be present both in irradiated and non-irradiated samples. In the case of aromatic herbs, the proposed official CEN protocol for irradiated food containing cellulose was used. (author)

  1. ESR identification of irradiated foodstuffs: LARQUA research

    Energy Technology Data Exchange (ETDEWEB)

    Raffi, J [Laboratoire de Recherche sur la Qualite des Aliments, Marseille (France)

    1997-12-31

    As electron spin resonance (ESR) spectroscopy is the leading method for identification of irradiated foodstuffs, meat and fish bones, fruit and relative products (of vegetable origin), sea-food etc. were studied. In order to prepare a large co-trial on ESR identification of irradiation of irradiated foodstuffs, experiments were carried out at LARQUA, especially on fruits and vegetables. The radicals induced in the fruit pulp are not stable because the water content of fruit is generally high, but ESR can be used with dried fruit or dry components such as achenes, pips or stones. Different responses are observed, depending on the fruit. In ``sugatype`` fruits (papaya, dried grapes), an ESR multicomponent signal is radio-induced, but the non-irradiated fruit presents no ESR signal or a single-line, while in ``cellulose type`` fruits (pistachio nut, berries), a triplet is induced. But a six line signal due to Mn{sup 2+} and a central single line may also be present both in irradiated and non-irradiated samples. In the case of aromatic herbs, the proposed official CEN protocol for irradiated food containing cellulose was used. (author).

  2. ESR dating of the fault rocks

    International Nuclear Information System (INIS)

    Lee, Hee Kwon

    2005-01-01

    We carried out ESR dating of fault rocks collected near the nuclear reactor. The Upcheon fault zone is exposed close to the Ulzin nuclear reactor. The space-time pattern of fault activity on the Upcheon fault deduced from ESR dating of fault gouge can be summarised as follows : this fault zone was reactivated between fault breccia derived from Cretaceous sandstone and tertiary volcanic sedimentary rocks about 2 Ma, 1.5 Ma and 1 Ma ago. After those movements, the Upcheon fault was reactivated between Cretaceous sandstone and fault breccia zone about 800 ka ago. This fault zone was reactivated again between fault breccia derived form Cretaceous sandstone and Tertiary volcanic sedimentary rocks about 650 ka and after 125 ka ago. These data suggest that the long-term(200-500 k.y.) cyclic fault activity of the Upcheon fault zone continued into the Pleistocene. In the Ulzin area, ESR dates from the NW and EW trend faults range from 800 ka to 600 ka NE and EW trend faults were reactivated about between 200 ka and 300 ka ago. On the other hand, ESR date of the NS trend fault is about 400 ka and 50 ka. Results of this research suggest the fault activity near the Ulzin nuclear reactor fault activity continued into the Pleistocene. One ESR date near the Youngkwang nuclear reactor is 200 ka

  3. Gene Expression Analyses of HER-2/neu and ESR1 in Patients with Breast Cancer

    Directory of Open Access Journals (Sweden)

    Omid Kheyri Nadergoli

    2017-10-01

    Full Text Available ABSTRACT Background: Her-2 and ESR1 genes, that interact in the cell signaling pathway, are the most important molecular markers of breast cancer, which have been amplified or overexpressed in 30% and 70%, respectively. This study was performed to evaluate the gene expression levels of Her-2 and ESR1 genes in tumor cells and its adjacent normal tissue of breast cancer patients and compared them whit clinical-pathological features. Methods: In total, 80 tissue specimens from 40 patients, with an average age of 48.47 years, were examined by Real-time PCR technique, and ultimately evaluated the expression level of Her-2 and ESR1genes. The data were analyzed by REST 2009 V2.0.13 statistical software. Results: HER2 and ESR1 overexpression was identified in 19 (48% and 12 (30% of 40 patients respectively, which was higher and lower than that recorded in international statistics, respectively. ESR1 overexpression was associated with Stage 3A and lymph node involvement 2 (N2 (P = 0.04 and P = 0.047, respectively. No significant correlation was observed between the expression of HER2 and ESR1 and other clinical-pathological features, however, the relative differences were identified in the expression levels of genes between main group and groups that were classified according to the clinical-pathological features and age. Conclusions: Overexpression of Her-2 and ESR1 genes in the patients of our study are higher and lower than international statistics, respectively, indicating the differences in genetic, environmental and ethnic factors that involved in the developing of breast cancer.

  4. Calculation of age-dependent effective doses for external exposure using the MCNP code

    International Nuclear Information System (INIS)

    Hung, Tran Van

    2013-01-01

    Age-dependent effective dose for external exposure to photons uniformly distributed in air were calculated. Firstly, organ doses were calculated with a series of age-specific MIRD-5 type phantoms using the Monte Carlo code MCNP. The calculations were performed for mono-energetic photon sources with source energies from 10 keV to 5 MeV and for phantoms of newborn, 1, 5, 10, and 15 years-old and adult. Then, the effective doses to the different age-phantoms from the mono-energetic photon sources were estimated based on the obtained organ doses. From the calculated results, it is shown that the effective doses depend on the body size; the effective doses in younger phantoms are higher than those in the older phantoms, especially below 100 keV. (orig.)

  5. Calculation of age-dependent effective doses for external exposure using the MCNP code

    Energy Technology Data Exchange (ETDEWEB)

    Hung, Tran Van [Research and Development Center for Radiation Technology, ThuDuc, HoChiMinh City (VT)

    2013-07-15

    Age-dependent effective dose for external exposure to photons uniformly distributed in air were calculated. Firstly, organ doses were calculated with a series of age-specific MIRD-5 type phantoms using the Monte Carlo code MCNP. The calculations were performed for mono-energetic photon sources with source energies from 10 keV to 5 MeV and for phantoms of newborn, 1, 5, 10, and 15 years-old and adult. Then, the effective doses to the different age-phantoms from the mono-energetic photon sources were estimated based on the obtained organ doses. From the calculated results, it is shown that the effective doses depend on the body size; the effective doses in younger phantoms are higher than those in the older phantoms, especially below 100 keV. (orig.)

  6. ESR study of the radiolysis of cellobiose, cellulose-containing materials, and their mixtures with methyl methacrylate

    International Nuclear Information System (INIS)

    Kozlova, E.Y.; Shostenko, A.G.; Ermolaev, S.V.

    1995-01-01

    The ESR spectra of γ-irradiated cellobiose, paper waste, and cellulose extracted from paper waste and waste pulp sludge were analyzed. The kinetics of formation and decay of cellobiose radicals were investigated, and the radiation-chemical yields of the radicals formed in cellulose-containing materials were calculated. The ESR spectra of cellobiose irradiated in the presence of methyl methacrylate (MMA) were obtained. A probable mechanism of MMA grafting onto cellulose-containing matrices is considered

  7. Identification of irradiated pepper by ESR measurement

    International Nuclear Information System (INIS)

    Morishita, Norio; Kume, Tamikazu; Kawakami, Waichiro; Ishigaki, Isao

    1988-01-01

    The possibility of using electron spin resonance (ESR) for identification of irradiated black and white pepper was examined. The ESR spectra induced by irradiation with 10 kGy are clearly distinguishable from that of unirradiated samples. The intensity of signal induced by irradiation was markedly reduced during 2 weeks storage but it was slowly reduced on further storage. The difference of intensity between the irradiated and unirradiated samples can be distinguished after 13 weeks storage. In this experiment, ground black pepper, ground white pepper and whole white pepper can be identified after 13 weeks. On the other hand, whole black pepper cannot be identified after 8 weeks because of the variation of values. It suggests that the suitable method for sample preparation such as separation of pellicle of whole black pepper is required before ESR measurement. (author)

  8. ESR application to radiation chemistry of polymers

    International Nuclear Information System (INIS)

    Kashiwabara, H.

    1988-01-01

    Important results obtained in our group in the field of ESR application to the study of irradiated polymers are summarized. They are the analysis of the decay reaction of the free radicals, spur-like trapping of the free radicals and the related discussions. A diffusion controlled bimolecular reaction scheme was a good way of analyzing the data of the decay reaction. Power saturation phenomenon of ESR spectra of the free radicals showed a circumstance of the spur-like trapping of the free radicals in irradiated polyethylene. The phenomenon of spur-like trapping was quite consistent with the interpretation of the decay reaction of the free radicals. (author)

  9. Submillimeter wave ESR of copper-oxides

    International Nuclear Information System (INIS)

    Ohta, Hitoshi; Motokawa, Mitsuhiro

    1993-01-01

    Since the discovery of high T c superconductors the magnetism of various copper-oxides has attracted much interest. Especially the magnetism of strong spin correlation systems in various CuO 4 networks is of great interest because it is well known that the superconductivity is occurring in the CuO 2 plane of the high T c superconductors. Here the authors will show some of their work done on copper-oxides by submillimeter wave ESR. The submillimeter wave ESR can provide the frequency region of 90 ∼ 3,100 GHz and the pulse magnetic field up to 30T

  10. High-dose dosimetry using electron spin resonance (ESR) spectroscopy

    International Nuclear Information System (INIS)

    Kojima, Takuji; Tanaka, Ryuichi

    1992-01-01

    An electron spin resonance (ESR) dosimeter capable of measuring large doses of radiation in radiotherapy and radiation processing is outlined. In particular, an alanine/ESR dosimeter is discussed, focusing on the development of elements, the development of the ESR dosimetric system, the application of alanine/ESR dosimeter, and basic researches. Rod elements for gamma radiation and x radiation and film elements for electron beams are described in detail. The following recent applications of the alanine/ESR dosimeter are introduced: using as a transfer dosimeter, applying to various types of radiation, diagnosing the deterioration of radiological materials and equipments, and applying to ESR imaging. The future subjects to be solved in the alanine/ESR dosimetric system are referred to as follows: (1) improvement of highly accurate elements suitable for the measurement of various types of radiation, (2) establishment of sensitive calibration method of the ESR equipment itself, and (3) calibration and standardization of radiation doses. (K.N.) 65 refs

  11. The result of Alanine/ESR dosimetry at Wolsung unit 1

    International Nuclear Information System (INIS)

    Park, Byeong Ryong; Choi, Hoon; Lim, Young Khi

    2008-01-01

    It needs accurate estimation of radiation level for verifying machinery and cable in Nuclear Power Plant. Therefore, in this study, we used ESR(Electron Spin Resonance) system for estimate dose of Alanine dosimeter. Alanine/ESR dosimetry, already known as a dosimetric method in medical and industrial field, was applied to estimate dose quantity at cable locations within a nuclear power plant as a part of equipment qualification program. Alanine/ESR dosimetry of absorbed dose range is 1 - 100 KGy. The alanine dosimeter is not significantly affected by temperature and fading is limited to 1% per year. The alanine dosimeters were fixed on the targeted cable or nearest position to measure dose quantity to get accurate value. Alanine dosimeters were scanned by commercially used two different ESR systems, e-scan and EMX series for alanine dosimeters. To estimate more accurate dose, two environmental correction factors, irradiation temperature and dosimeter weight, were used in calculation of absorbed dose quantity. In this study, dose values which are alinine dosimeter from Wolsong unit 1 are measured by two ESR systems. And then the results was compared each other

  12. Calculation of age-dependent dose conversion coefficients for radionuclides uniformly distributed in air

    International Nuclear Information System (INIS)

    Hung, Tran Van; Satoh, Daiki; Takahashi, Fumiaki; Tsuda, Shuichi; Endo, Akira; Saito, Kimiaki; Yamaguchi, Yasuhiro

    2005-02-01

    Age-dependent dose conversion coefficients for external exposure to photons emitted by radionuclides uniformly distributed in air were calculated. The size of the source region in the calculation was assumed to be effectively semi-infinite in extent. Firstly, organ doses were calculated with a series of age-specific MIRD-5 type phantoms using MCNP code, a Monte Carlo transport code. The calculations were performed for mono-energetic photon sources of twelve energies from 10 keV to 5 MeV and for phantoms of newborn, 1, 5, 10 and 15 years, and adult. Then, the effective doses to the different age-phantoms from the mono-energetic photon sources were estimated based on the obtained organ doses. The calculated effective doses were used to interpolate the conversion coefficients of the effective doses for 160 radionuclides, which are important for dose assessment of nuclear facilities. In the calculation, energies and intensities of emitted photons from radionuclides were taken from DECDC, a recent compilation of decay data for radiation dosimetry developed at JAERI. The results are tabulated in the form of effective dose per unit concentration and time (Sv per Bq s m -3 ). (author)

  13. Lung deposition of sub-micron aerosols calculated as a function of age and breathing rate

    International Nuclear Information System (INIS)

    James, A.C.

    1978-01-01

    Experimental measurements of lung deposition and especially of regional deposition, of aerosols in the sub-micron size range have been so few that it is worthwhile establishing a method of calculation. A computer routine has therefore been developed to calculate aerosol deposition in successive bronchial and bronchiolar generations of the Weibel 'A' model of human lung for the sub-micron size range where deposition occurs solely by diffusion. This model can be scaled to represent lungs at various ages and vital capacities. Some calculated results are presented here and compared with measurements of lung deposition made under carefully controlled conditions in humans. (author)

  14. Investigations of radical primary processes by ESR pulse radiolysis and ESR laser photolysis experiments

    International Nuclear Information System (INIS)

    Beckert, D.; Mehler, K.; Naumann, W.

    1984-08-01

    The Chemically Induced Magnetic Polarization of Electrons (CIDEP) describes the anomalies of ESR intensities of free radicals which react chemically. In this paper the fundamentals and some experimental results of the CIDEP effect are summarized. (author)

  15. Radiation dosimetry by ESR in bone

    Energy Technology Data Exchange (ETDEWEB)

    Gallegos, R. (Universidad de San Agustin de Arequipa (Peru)); Marticorena, B. (Instituto Peruano de Energia Nuclear, Lima)

    1983-05-01

    The absorption speed in bovine bone samples irradiated with a /sup 90/Sr ..beta..-source of 45 mCi is studied with ESR. The signal changes linearly with the absorbed quantity of radiation to a maximum dose of 1.5 x 10/sup 6/ rads. This positive result allows to foresee the use of bone as a radiation dosimeter.

  16. Radiation dosimetry by ESR in bone

    International Nuclear Information System (INIS)

    Gallegos, R.; Marticorena, B.

    1983-01-01

    The absorption speed in bovine bone samples irradiated with a 90 Sr β-source of 45 mCi is studied with ESR. The signal changes linearly with the absorbed quantity of radiation to a maximum dose of 1.5 x 10 6 rads. This positive result allows to foresee the use of bone as a radiation dosimeter

  17. ESR dating of marine fossil shells

    International Nuclear Information System (INIS)

    Radtke, U.; Mangini, A.; Gruen, R.

    1985-01-01

    In order to establish the relatively new ESR dating method for marine shells a detailed comparison with the independent U-series technique was carried out. Agreement of both dating methods with the geological classification is strongly dependent on the species investigated and environmental conditions. Several problems encountered in the determination of the accumulated dose as well as the annual dose are discussed. (author)

  18. ESR dating of marine fossil shells

    Energy Technology Data Exchange (ETDEWEB)

    Radtke, U; Mangini, A; Gruen, R

    1985-01-01

    In order to establish the relatively new ESR dating method for marine shells a detailed comparison with the independent U-series technique was carried out. Agreement of both dating methods with the geological classification is strongly dependent on the species investigated and environmental conditions. Several problems encountered in the determination of the accumulated dose as well as the annual dose are discussed.

  19. ESR investigations of gamma irradiated beryllium ceramics

    International Nuclear Information System (INIS)

    Ryabikin, Yu.A.; Polyakov, A.I.; Petukhov, Yu.V.; Bitenbaev, M.I.; Zashkvara, O.V.

    2000-01-01

    In this report the result of ESR- investigation of kinetics of radiation paramagnetic defects accumulated in beryllium ceramics under gamma irradiation are presented. The data on quantum yield and destruction rate constants of these defects under ionizing irradiation are obtained. (orig.)

  20. ESR investigations of gamma irradiated beryllium ceramics

    Energy Technology Data Exchange (ETDEWEB)

    Ryabikin, Yu A; Polyakov, A I; Petukhov, Yu V; Bitenbaev, M I; Zashkvara, O V [Physical-Technical Inst., Almaty (Kazakhstan)

    2000-04-01

    In this report the result of ESR- investigation of kinetics of radiation paramagnetic defects accumulated in beryllium ceramics under gamma irradiation are presented. The data on quantum yield and destruction rate constants of these defects under ionizing irradiation are obtained. (orig.)

  1. ESR dosimetric properties of some biomineral materials

    International Nuclear Information System (INIS)

    Hassan, Gamal M.; Sharaf, M.A.

    2005-01-01

    Dosimetric properties of g-irradiated modern coral and bioactive glass (Bio-G) samples analyzed with electron spin resonance (ESR) have been separately reported (Hassan et al., 2004; Sharaf and Hassan, 2004) and compared with alanine. These are combined here to allow a three-way comparison between these materials

  2. ESR dosimetric properties of some biomineral materials

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, Gamal M. [Department of Ionizing Radiation Metrology, National Institute for Standards (NIS), Tersa Street, El-Haram, El-Giza, P.O. Box 136 Giza, El-Giza (Egypt)]. E-mail: gamalhassan65@hotmail.com; Sharaf, M.A. [Department of Ionizing Radiation Metrology, National Institute for Standards (NIS), Tersa Street, El-Haram, El-Giza, P.O. Box 136 Giza, El-Giza (Egypt)

    2005-02-01

    Dosimetric properties of g-irradiated modern coral and bioactive glass (Bio-G) samples analyzed with electron spin resonance (ESR) have been separately reported (Hassan et al., 2004; Sharaf and Hassan, 2004) and compared with alanine. These are combined here to allow a three-way comparison between these materials.

  3. ESR signals in quartz for the studies of earth surface processes

    Science.gov (United States)

    Toyoda, S.; Shimada, A., , Dr; Takada, M.

    2017-12-01

    Various ESR (electron spin resonance) signals are observed in quartz. As they are formed by natural radiation, the signals are useful in dating of geological events, such as volcanic eruption, faulting and sedimentation. It was also found that those paramagnetic defects can be fingerprints of sediments, to be used for studies in sediment provenance. The signal of the E1' center, unpaired electron at an oxygen vacancy, was first used for such studies. A method was proposed to estimate the number of the precursors (oxygen vacancies) from the E1' center intensity. The number of oxygen vacancies in quartz was found to have positive correlation with the crystallization age. Using this feature, studies were quite successful in aeolian dust. It was shown that the sources of aeolian dust deposited in northern part of Japanese Islands were different between in MIS1 and MIS 2. In combination with crystallinity index, the contributions of the dust components from three origins were quantitatively obtained. After these, the provenance studies on river sediments have started where the impurity centers in quartz were employed, which are the Al center, the Ti centers, and the Ge centers. Sediments of Kizu River, Mie to Nara prefectures in Central Japan are most extensively studied. Firstly, it was shown that each of possible sources of granitic quartz around the reaches has respective characteristics in the number of oxygen vacancies and the signal intensities of impurity centers. Secondary, by the artificial mixing experiments, the impurity signal intensities have the values consistent with the mixing ratio of the two samples of quartz with different intensities. At river junctions, the mixing ratios were calculated from the ESR signals. At some locations, the mixing ratio values obtained from one signal were consistent with the ones from another signal while at some locations they were not. The latter inconsistent results would indicate that the river sediments are

  4. Second interlaboratory-comparison project on ESR dating

    International Nuclear Information System (INIS)

    Barabas, M.; Walther, R.; Radtke, U.

    1993-01-01

    An intercomparison project on ESR dating in which 14 ESR groups participated was initiated. Each group was provided with two samples of a coral powder, one of which (Sample A) was a fossil coral with a mass spectrometric determined U/Th age. Sample B was a recent coral, irradiated with a definite γ-dose (checked by alanine dosimetry). In both cases the accumulated dose (AD) had to be determined (for sample A the U-content and age as well). Additionally, the chance of a calibration of γ-sources by alanine dosimeters was offered. The results show that the γ-source calibration is better then ± 5%, the mean value of the AD from sample A seems to agree with the expected AD but the mean AD value from sample B is overestimated, systematic errors occur due to the fitting procedure: the AD estimate depends on the maximum γ-dose used for the irradiation curve, the AD determination including the smallest systematic error gives correct values for sample B but too low values for sample A which may be caused by fading of the signal g = 2.0006. (author)

  5. The α-efficiency of corals and its importance for ESR-dating

    International Nuclear Information System (INIS)

    Malmberg, R.; Radtke, U.

    2000-01-01

    The uncertainty in an ESR age results almost completely from the error in the evaluation of the annual dose. In the case of corals, α-efficiency has a high influence on D E (Paleodose). The published k α -values vary from 0.05 to 0.2, so the correct determination of k α is crucial. In this experiment, based on direct irradiation with an 241 Am-source, we used seven samples (20 aliquots for each sample) with different ages. The first aim was to improve the measurement conditions to reach a reliable data base for the α-efficiency calculation and the second was the question of age dependency of k α . With respect to the results of our experiments we propose an α-efficiency value for corals of 0.06-0.07 which leads to younger ages of about 7-10% less than with the k α factor of 0.05 we used in previous studies

  6. Phase transitions of natural corals monitored by ESR spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Vongsavat, V. [Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400 (Thailand); Winotai, P. [Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400 (Thailand); Meejoo, S. [Department of Chemistry, Faculty of Science, Mahidol University, Rama VI Road, Rajathevi, Bangkok 10400 (Thailand)]. E-mail: scsmj@mahidol.ac.th

    2006-01-15

    The main purpose of this work is to present a systematic study of structure of marine exoskeletons, Acropora coral and its structural transformation upon heat treatments. The coralline sample was ground and characterized as powder throughout this work. Structural identifications of all samples have been confirmed using X-ray diffraction and IR spectroscopy. It was clearly found that the fresh specimen is made of aragonite, a common phase of the mineral CaCO{sub 3}. Thermal analyses, DSC and TGA were used to monitor structural and thermal decompositions and an irreversible solid-state phase transition from aragonite to calcite of the marine carbonate. Next, the coral powder was annealed at specific temperatures over the range 350-900 deg. C, and the effects of heat treatment on the structure of coralline samples were carefully studied by Rietveld refinement method. In addition, we have examined Mn{sup 2+} paramagnetic ions and free radicals present in the coral and changes of those upon heating by using ESR spectroscopy. The local environments of Mn{sup 2+} ions were verified from the calculated ESR spectra using appropriate spin Hamiltonian parameters, i.e. gyromagnetic tensor g , zero-field splitting D and hyperfine tensor A . This work reported structures and compositions as well as physical, chemical and thermal properties of the coralline material upon heat treatments qualitatively and quantitatively.

  7. Phase transitions of natural corals monitored by ESR spectroscopy

    International Nuclear Information System (INIS)

    Vongsavat, V.; Winotai, P.; Meejoo, S.

    2006-01-01

    The main purpose of this work is to present a systematic study of structure of marine exoskeletons, Acropora coral and its structural transformation upon heat treatments. The coralline sample was ground and characterized as powder throughout this work. Structural identifications of all samples have been confirmed using X-ray diffraction and IR spectroscopy. It was clearly found that the fresh specimen is made of aragonite, a common phase of the mineral CaCO 3 . Thermal analyses, DSC and TGA were used to monitor structural and thermal decompositions and an irreversible solid-state phase transition from aragonite to calcite of the marine carbonate. Next, the coral powder was annealed at specific temperatures over the range 350-900 deg. C, and the effects of heat treatment on the structure of coralline samples were carefully studied by Rietveld refinement method. In addition, we have examined Mn 2+ paramagnetic ions and free radicals present in the coral and changes of those upon heating by using ESR spectroscopy. The local environments of Mn 2+ ions were verified from the calculated ESR spectra using appropriate spin Hamiltonian parameters, i.e. gyromagnetic tensor g , zero-field splitting D and hyperfine tensor A . This work reported structures and compositions as well as physical, chemical and thermal properties of the coralline material upon heat treatments qualitatively and quantitatively

  8. ESR studies on degradation processes in polyethyleneterephtalate

    International Nuclear Information System (INIS)

    Chipara, M.; Chipara, M.D.; Georgescu, L.; Constantinescu, L.; Morosanu, C.

    2002-01-01

    Complete text of publication follows. The generation of free radicals by degradation processes (thermal, plasma and radiation induced) is analyzed. Details regarding the generation of free radicals, their interactions, and kinetics, as revealed by electron spin resonance (ESR), with emphasis on laser beam degradation, are discussed. Some ESR lines of laser-irradiated polyethyleneterephtalate (PET), recorded at room temperature, are shown in Figure 1. The lines are narrow singlets located around g=2.003. The resonance line amplitude, width and double integral of the resonance line are affected by the power of the incident beam. The common features of these degradation processes (universal behavior) as well as the fingerprints of each degradation process are analyzed in detail

  9. ESR study of free radicals in mango

    Science.gov (United States)

    Kikuchi, Masahiro; Hussain, Mohammad S.; Morishita, Norio; Ukai, Mitsuko; Kobayashi, Yasuhiko; Shimoyama, Yuhei

    2010-01-01

    An electron spin resonance (ESR) spectroscopic study of radicals induced in irradiated fresh mangoes was performed. Mangoes in the fresh state were irradiated with γ-rays, lyophilized and then crushed into a powder. The ESR spectrum of the powder showed a strong main peak at g = 2.004 and a pair of peaks centered at the main peak. The main peak was detected from both flesh and skin specimens. This peak height gradually decreased during storage following irradiation. On the other hand, the side peaks showed a well-defined dose-response relationship even at 9 days post-irradiation. The side peaks therefore provide a useful means to define the irradiation of fresh mangoes.

  10. IAEA reference dosimeter: Alanine-ESR

    International Nuclear Information System (INIS)

    Mehta, K.; Girzikowsky, R.

    1999-01-01

    Since 1985, the IAEA has been using alanine-ESR as a transfer dosimeter for its dose quality audit service, namely the International Dose Assurance Service. The alanine dosimeters are rod-type containing 70 wt% DL--α-alanine and 30 wt% polystyrene. We have two self-shielded gamma facilities for the calibration of the dosimetry system, where the temperature within the irradiation chamber can be controlled by a specially designed unit. A 4th order polynomial is fitted to the 16 data points in the dose range of 100 Gy to 50 kGy. The measured value of the irradiation temperature coefficient at two dose values (15 and 45 kGy) is 0.23 %/deg. C. Also, the ESR-response was followed for several dosimeters for about 8 months to study the post-irradiation effect. A value of 0.008 %/day was observed for the fading of the response for two dose values (15 and 45 kGy) and three irradiation temperatures (15, 27 and 40 deg. C). The effect of the analysis temperature on the ESR response was also studied. The combined relative uncertainty for the IAEA alanine-ESR dosimetry system is 1.5% (k=1). This includes that transferred from the primary laboratory for the dose rate measurements of the gamma facilities, dosimetry system calibration uncertainties, batch variability and uncertainty in the curve fitting procedure. This value however does not include the contribution due to the irradiation temperature correction which is applied when it differs from that during calibration; this component being specific for each dose measurement. (author)

  11. Calculation of Activation Energy by OIT Method for aging evaluation of NPP cable

    International Nuclear Information System (INIS)

    Park, Kyung-Heun; Kim, Jong-Seog; Cho, Bok-Gee

    2006-01-01

    Extending the lifetime of nuclear power plant is one of the most important concerns in the world nuclear industry. Cables are one of the long live items which have not been considered to be replaced during the design life of NPP. In order to simulate the natural aging in nuclear power plant, a study on accelerated aging needs to be conducted and to carry out the accelerated aging test, we must calculate the activation energy of the cable if we don't have the activation energy information. The activation energy is the most important element and it can be calculated by indentor modulus and elongation data and so on. But there is often only a limited quantity of material available in the deposit for testing, so it is important the samples for any destructive test are conserved as much as possible. But if there is only a limited quantity of the material, OIT(Oxidation Induction Time) is very useful with calculating activation energy and evaluation of the cable lifetime

  12. ESR dating of submarine hydrothermal activities using barite in sulfide deposition

    Science.gov (United States)

    Toyoda, S.; Fujiwara, T.; Ishibashi, J.; Isono, Y.; Uchida, A.; Takamasa, A.; Nakai, S.

    2012-12-01

    The temporal change of submarine hydrothermal activities has been an important issue in the aspect of the evolution of hydrothermal systems which is related with ore formation (Urabe, 1995) and biological systems sustained by the chemical species arising from hydrothermal activities (Macdonald et al., 1980). Determining the ages of the hydrothermal deposit will provide essential information on such studies. Dating methods using disequilibrium between radioisotopes such as U-Th method (e.g. You and Bickle, 1998), 226}Ra-{210Pb and 228}Ra-{228Th method (e.g. Noguchi et al., 2011) have been applied to date submarine hydrothermal deposits. ESR (electron spin resonance) dating method is commonly applied to fossil teeth, shells, and quartz of Quaternay period where the natural accumulated dose is obtained from the intensities of the ESR signals which are created by natural radiation. The natural dose is divided by the dose rate to the mineral/sample to deduce the age. Okumura et al., (2010) made the first practical application of ESR (electron spin resonance) dating technique to a sample of submarine hydrothermal barite (BaSO4) to obtain preliminary ages, where Kasuya et al. (1991) first pointed out that barite can be used for ESR dating. Knowing that ESR dating of barite is promising, in this paper, we will present how we have investigated each factor that contributes ESR dating of barite in submarine hydrothermal sulfide deposition. (1) The best ESR condition for measuring the SO3- signal in barite is with the microwave power of 1mW and modulation amplitude of 0.1mT. (2) As results of heating experiments, the signal was found to be stable for the dating age range of several thousands. (3) 226Ra replacing Ba in barite is the source of the radiation. The amount of radioactive elements in sulfide mineral surrounding barite is negligible. (4) The external radiation from the sea water is negligible even in the submarine hydrothermal area where the radiation level is much

  13. ESR analysis of irradiated frogs' legs and fishes

    International Nuclear Information System (INIS)

    Raffi, J.; Agnel, J.-P.; Evans, J.C.; Rowlands, C.C.; Lesgards, G.

    1989-01-01

    Electron spin resonance (ESR) spectral analysis of different parts (bones, scales, jaw, etc.) from ionized (irradiated) frozen frogs' legs and fishes (brown trout and sardine) were recorded. There is always present, after treatment, a signal due to the irradiation. ESR and ENDOR experiments lead us to assign it to h 1 centers from hydroxyapatite, as in the case of other irradiated meat bones. The use of ESR to prove whether one of these foods has been irradiated or not is discussed. (author)

  14. Correlation of ESR with lyoluminescence dosimetry using some sugars

    International Nuclear Information System (INIS)

    Azorin, Juan; Gutierrez, Alicia; Munoz, Eduardo; Gleason, Roberto

    1989-01-01

    Most applications involving ESR dosimetry currently center on aminoacids because of their relative tissue equivalence. Sugars, however, in addition to possessing high sensitivity and stability in their ESR and LL responses, are widely available as chemical reagents and as commercial sugar. In the present study, dosimetric characteristics of mannose, trehalose, sucrose and commercial sugar obtained by means of ESR and LL techniques are reported. Doses measured by both methods showed agreement within 5%. (author)

  15. ESR spectroscopy for detecting gamma-irradiated dried vegetables and estimating absorbed doses

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Joong-Ho; Chung, Hyung-Wook; Byun, Myung-Woo

    2000-03-01

    In view of an increasing demand for food irradiation technology, the development of a reliable means of detection for the control of irradiated foods has become necessary. Various vegetable food materials (dried cabbage, carrot, chunggyungchae, garlic, onion, and green onion), which can be legally irradiated in Korea, were subjected to a detection study using ESR spectroscopy. Correlation coefficients (R{sup 2}) between absorbed doses (2.5-15 kGy) and their corresponding ESR signals were identified from ESR signals. Pre-established threshold values were successfully applied to the detection of 54 coded unknown samples of dried clean vegetables (chunggyungchae, Brassica camestris var. chinensis), both non-irradiated and irradiated. The ESR signals of irradiated chunggyungchae decreased over a longer storage time, however, even after 6 months of ambient storage, these signals were still distinguishable from those of non-irradiated samples. The most successful estimates of absorbed dose (5 and 8 kGy) were obtained immediately after irradiation using a quadratic fit with average values of 4.85 and 8.65 kGy being calculated. (author)

  16. Testing cosmic dose rate models for ESR: Dating corals and molluscs on San Salvador, Bahamas

    International Nuclear Information System (INIS)

    Deely, A.E.; Blackwell, B.A.B.; Mylroie, J.E.; Carew, J.L.; Blickstein, J.I.B.; Skinner, A.R.

    2011-01-01

    Sealevel curves are best developed on tectonically stable coastlines, like San Salvador, where eolianites preserve transgressive and regressive phases associated with Quaternary high seastands, while reef facies mark the highstands. At 11 locations around San Salvador, terrestrial molluscs (Cerion) from the eolianites, lagoonal bivalves (Codakia), and corals from the highstand deposits were dated by ESR. Volumetrically averaged sedimentary dose rates were calculated from sedimentary geochemistry and time-averaged cosmic dose rates from each sample's current and past geologic contexts. Rice Bay Formation corals dated at 3.9 ± 0.3 to 7.1 ± 0.4 ka (OIS 1). Minimum ages for the Cockburn Town Member's regressive phase ranged from 49 ± 6 to 75 ± 8 ka, correlating with OIS 3-4. Codakia dates showed that an OIS 5a sealevel approached modern levels at 91-78 ka. In situ corals from the Cockburn Town Reef averaged from 127 ± 6 to 138 ± 10 ka, correlating well with OIS 5e. Ages from the Reef's rubble zones hint that some coral reefs grew as early as OIS 7, but were likely reworked during OIS 5. San Salvador preserves deposits from three mid to late Quaternary highstands above, and as many as three that closely approach, modern sealevel.

  17. Beta-gradient isochron dating of thin tooth enamel layers using ESR

    International Nuclear Information System (INIS)

    Marsh, R.E.Rebeccah E.; Rink, W.J.W. Jack

    2000-01-01

    The theoretical and experimental basis for the development of a new dating technique using beta-gradient isochrons and ESR is presented. For uranium-free portions of enamel adjacent to sediment, we can determine a beta-dose gradient due to sources in the nearest 2 mm layer of the sediment. If the equivalent dose to successive layers of enamel is plotted against the beta dose rate to each layer, an estimate of the age (equal to the slope of the line) that depends only on the environmental beta dose rate can be determined. Experimental methods and results for four teeth are discussed. The significance of this approach lies in its ability to isolate an age estimate that is independent of the uranium uptake model, since only portions of the enamel which are far away enough from internal sources of uranium, such as dentine, are used. In addition, this technique provides a time-averaged estimate of the actual gamma plus cosmic dose rate provided that a reasonable estimate of the average moisture content is used to calculate the environmental beta dose rate

  18. Testing cosmic dose rate models for ESR: Dating corals and molluscs on San Salvador, Bahamas

    Energy Technology Data Exchange (ETDEWEB)

    Deely, A.E. [RFK Science Research Institute, Glenwood Landing, NY, 11547-0866 (United States); Blackwell, B.A.B., E-mail: bonnie.a.b.blackwell@williams.edu [RFK Science Research Institute, Glenwood Landing, NY, 11547-0866 (United States); Dept. of Chemistry, Williams College, Williamstown MA, 01267-2692 (United States); Mylroie, J.E. [Dept. of Geosciences, Mississippi State University, MS, 39762-5448 (United States); Carew, J.L. [Dept. of Geology and Environmental Geosciences, College of Charleston, Charleston, SC 29424 (United States); Blickstein, J.I.B. [RFK Science Research Institute, Glenwood Landing, NY, 11547-0866 (United States); Skinner, A.R. [RFK Science Research Institute, Glenwood Landing, NY, 11547-0866 (United States); Dept. of Chemistry, Williams College, Williamstown MA, 01267-2692 (United States)

    2011-09-15

    Sealevel curves are best developed on tectonically stable coastlines, like San Salvador, where eolianites preserve transgressive and regressive phases associated with Quaternary high seastands, while reef facies mark the highstands. At 11 locations around San Salvador, terrestrial molluscs (Cerion) from the eolianites, lagoonal bivalves (Codakia), and corals from the highstand deposits were dated by ESR. Volumetrically averaged sedimentary dose rates were calculated from sedimentary geochemistry and time-averaged cosmic dose rates from each sample's current and past geologic contexts. Rice Bay Formation corals dated at 3.9 {+-} 0.3 to 7.1 {+-} 0.4 ka (OIS 1). Minimum ages for the Cockburn Town Member's regressive phase ranged from 49 {+-} 6 to 75 {+-} 8 ka, correlating with OIS 3-4. Codakia dates showed that an OIS 5a sealevel approached modern levels at 91-78 ka. In situ corals from the Cockburn Town Reef averaged from 127 {+-} 6 to 138 {+-} 10 ka, correlating well with OIS 5e. Ages from the Reef's rubble zones hint that some coral reefs grew as early as OIS 7, but were likely reworked during OIS 5. San Salvador preserves deposits from three mid to late Quaternary highstands above, and as many as three that closely approach, modern sealevel.

  19. Fiber Bragg Gratings, IT Techniques and Strain Gauge Validation for Strain Calculation on Aged Metal Specimens

    Directory of Open Access Journals (Sweden)

    Ander Montero

    2011-01-01

    Full Text Available This paper studies the feasibility of calculating strains in aged F114 steel specimens with Fiber Bragg Grating (FBG sensors and infrared thermography (IT techniques. Two specimens have been conditioned under extreme temperature and relative humidity conditions making comparative tests of stress before and after aging using different adhesives. Moreover, a comparison has been made with IT techniques and conventional methods for calculating stresses in F114 steel. Implementation of Structural Health Monitoring techniques on real aircraft during their life cycle requires a study of the behaviour of FBG sensors and their wiring under real conditions, before using them for a long time. To simulate aging, specimens were stored in a climate chamber at 70 °C and 90% RH for 60 days. This study is framed within the Structural Health Monitoring (SHM and Non Destructuve Evaluation (NDE research lines, integrated into the avionics area maintained by the Aeronautical Technologies Centre (CTA and the University of the Basque Country (UPV/EHU.

  20. Identification of irradiated mangoes by means of ESR spectroscopy

    International Nuclear Information System (INIS)

    Bustos, M.E.; Romero, M.E.; Gutierrez, A.; Azorin, J.

    1996-01-01

    Samples of mango varieties Tommy Atkins, Haiden and Ataulfo were irradiated with 60 Co gamma radiation at doses in the range 0.15-1.0 kGy, and stored at room temperature for lapses of time up to 72 h. They were then studied by ESR spectrometry. Results show that the ESR signal of the irradiated samples is higher than that of the unirradiated samples, and this is found even at the minimum radiation dose of 0.15 kGy. The ESR signal remained stable during the storage time. The ESR signals obtained for hydroheated mangoes show insignificant differences with respect to the control samples. (author)

  1. Isotopic fractionation of NBS oxalic acid and its influence in the calculated age of materials

    International Nuclear Information System (INIS)

    Nehmi, V.A.

    1979-10-01

    The intensity of the isotopic fractionation during the oxidation of NBS oxalic acid to carbon dioxide was checked. 30 reactions of oxidation of NBS oxalic acid with potassium permanganate were made. The resultant isotopic composition of CO 2 has been determined with a mass-spectrometer. A conclusion has been reached that the average of Δ 13 C is - 18.9% o with variation between - 17.7 and - 21.2%o. For values of Δ 13 C equal to - 22.0%o, the calculated age with isotopic correction shows the following deviations in relation to non-corrected age: 4% for materials of 1,000 years and 0.3% for 20,000 years.(Author) [pt

  2. The influence of surface modification, coating agents and pH value of aqueous solutions on physical properties of magnetite nanoparticles investigated by ESR method

    Energy Technology Data Exchange (ETDEWEB)

    Dobosz, Bernadeta, E-mail: benia@amu.edu.pl [Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań (Poland); Krzyminiewski, Ryszard [Medical Physics Division, Faculty of Physics, Adam Mickiewicz University, Umultowska 85, 61-614 Poznań (Poland); Kurczewska, Joanna; Schroeder, Grzegorz [Faculty of Chemistry, Adam Mickiewicz University, Umultowska 89B, 61-614 Poznań (Poland)

    2017-05-01

    The article presents the results of electron spin resonance (ESR) studies for aqueous solutions of functionalized superparamagnetic iron(II,III) oxide nanoparticles. The samples studied differed in type of organic ligands at the magnetite surface, type of coating agent and pH value of aqueous solutions. The ESR spectra of the samples were obtained at room temperature and at 230 K. The field cooling (FC) experiment was performed for selected samples, and the effective anisotropy field (H{sub K2}) and the first order magnetocrystalline anisotropy constant (K{sub 1}) was calculated. The process of the nanoparticles diffusion in different environments (human blood, human serum) forced by an inhomogeneous magnetic field was monitored and their interactions with different solvents have been discussed. It has been shown that ESR method is useful to observe the impact of organic ligands at the magnetite surface, type of coating agent and pH value of aqueous solutions on the properties of iron(II,III) oxide nanoparticles. - Highlights: • The influence of different organic ligands, coatings and pH values of aqueous solutions on the physical properties of the magnetite nanoparticles studied by ESR method. • Nanoparticles diffusion forced by inhomogeneous magnetic field monitored by ESR and explained. • A narrow line separated in ESR spectra by CREM. • The influence of different coatings and pH values of aqueous solutions on ESR spectra of TEMPO attached to the magnetite core.

  3. LENMODEL: A forward model for calculating length distributions and fission-track ages in apatite

    Science.gov (United States)

    Crowley, Kevin D.

    1993-05-01

    The program LENMODEL is a forward model for annealing of fission tracks in apatite. It provides estimates of the track-length distribution, fission-track age, and areal track density for any user-supplied thermal history. The program approximates the thermal history, in which temperature is represented as a continuous function of time, by a series of isothermal steps of various durations. Equations describing the production of tracks as a function of time and annealing of tracks as a function of time and temperature are solved for each step. The step calculations are summed to obtain estimates for the entire thermal history. Computational efficiency is maximized by performing the step calculations backwards in model time. The program incorporates an intuitive and easy-to-use graphical interface. Thermal history is input to the program using a mouse. Model options are specified by selecting context-sensitive commands from a bar menu. The program allows for considerable selection of equations and parameters used in the calculations. The program was written for PC-compatible computers running DOS TM 3.0 and above (and Windows TM 3.0 or above) with VGA or SVGA graphics and a Microsoft TM-compatible mouse. Single copies of a runtime version of the program are available from the author by written request as explained in the last section of this paper.

  4. Quartz Ti-center in ESR dating of Xigeda formation in Sichuanand contrast with magnetic stratigraphic profiles

    International Nuclear Information System (INIS)

    Wang Ping; Li Jianping; Liu Chunru; Han Fei; Gao Lu; Wang Jiancun

    2011-01-01

    Xigeda formation is a famous fluvial-lacustrine sedimentation formed in late cenozoic in southwest China, distributed in the valley of Dadu River, Anning River, Chin-sha River etc. The age of Xigeda formation,ranges between 4.18 and 1.78 Ma BP, depending on the magnetic stratigraphy research of the stratigraphic section. Quartz Ti-center in ESR dating of sand samples from several typical sections of Xigeda formation in Sichuan shows that they are sediments in mid-pleistocene. Comparing the ESR ages and mainly normal polarity, Xigeda formation can be confirmed in Brunhes epoch according to magnetic stratigraphy. (authors)

  5. ESR dosimetric properties of modern coral reef

    Energy Technology Data Exchange (ETDEWEB)

    Sharaf, M.A. E-mail: mokhtar_sharaf@yahoo.com; Hassan, Gamal M

    2004-06-01

    Modern coral reef samples from Egypt were irradiated with {sup 60}Co{gamma}-rays to study radicals for dosimetric materials with electron spin resonance (ESR). The ESR spectrum for the radical species in unirradiated coral is characterized by four signals with spectroscopic splitting factors of g=2.0056, 2.0030, 2.0006 and 1.997. The signal at g=2.0006{+-}0.0005 is ascribed to free rotation CO{sub 2}{sup -} radicals and used as a dosimetric one. The response to {gamma}-ray doses ranging from 5 to 10{sup 3} Gy and the thermal stability has been studied. The number of free radicals per 100 eV (G-value) was found to be 0.45 {+-} 0.1 and 0.9 {+-} 0.18 for coral and alanine, respectively. The lifetime of radicals and the activation energy were estimated from Arrhenius plots to be approximately 8 x 10{sup 5} {+-} 1.6 x 10{sup 5} years, and 1.12 eV, respectively.

  6. Application of ESR to identification of irradiated foodstuffs

    Energy Technology Data Exchange (ETDEWEB)

    Raffi, J. [Aix-Marseille-3 Univ., 13 - Marseille (France); Agnel, J.P. [CEA Centre d`Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Physiologie Vegetale et Ecosystemes; Belliardo, J.J. [BCR, Bruxelles (Belgium)

    1994-11-01

    The conditions required to use Electron Spin Resonance (ESR) in identification of irradiated foods is first described. Then we present the results of an intercomparison sponsored by the Community Bureau of Reference involving 22 european laboratories on meat and fish bones and fruits. Then the ESR protocols given to the BCR are described. (authors). 14 refs., 8 figs., 5 annexes.

  7. A method to improve application technique in Alanine/ESR dosimetry

    International Nuclear Information System (INIS)

    Choi, Hoon; Ha, Ju Hee; Choi, Won; Lim, Young Khi

    2008-01-01

    Full text: For long-term radiation monitoring to assess the cable aging in harsh condition of nuclear power plant, ESR dosimetry method using alanine dosimeters was already recommended in many technical document and paper. Several ESR dosimetry systems were already produced and used widely, but the actual application of these systems for industrial dosimetry needs careful consideration of error sources in process of dose measurement. The alanine dosimeters were measured by E-scan alanine analyzer system or EMX ESR spectrometer. For the accurate measurement of the dosimeters, we have studied various source of errors. First, this paper discusses sources of inaccuracy related to data processing. To make a meaningful dose assessment, the dosimeter measurements need to be compared with measurements made using certified dosimeters of known dose. This is achieved by performing the routine calibration procedure which creates a calibration curve and corresponding fit coefficients from measurements made with a set of dosimeters with known certified dose. The calibration curves in ESR dosimetry are usually constructed by means of the least-squares technique in its simplest variant. The recommended alternative linearity several replicate measurements of Y at each used X value. Also, measurement is subject to error, so repeat measurements will not be identical. A technical description of a linear calibration is assumed that the dispersion of the measurements is the same for each standard. But in some cases, the standard deviation has to be specified separately for each value of concentration. In this case, it used the WLS (Weighted Least-Squared Regression) method instead of the OLS (Ordinary Least-Squared Regression) method. Second, the precision of the ESR spectrum was showed as a reproducibility test for the two ESR systems. The reproducibility test was performed at an absorbed dose of 1 k Gy, which is at least three orders of magnitude above the background reading of an

  8. Status and outlook of the CRYRING@ESR project

    Energy Technology Data Exchange (ETDEWEB)

    Geithner, W., E-mail: w.geithner@gsi.de; Andelkovic, Z.; Beck, D.; Bräuning, H.; Bräuning-Demian, A. [GSI Helmholtzzentrum für Schwerionenforschung (Germany); Danared, H. [European Spallation Source ESS (Sweden); Dimopoulou, C. [GSI Helmholtzzentrum für Schwerionenforschung (Germany); Engström, M. [Fysikum, Stockholm University (Sweden); Fedotova, S.; Gorda, O.; Herfurth, F.; Hess, R. [GSI Helmholtzzentrum für Schwerionenforschung (Germany); Källberg, A. [Fysikum, Stockholm University (Sweden); Kleffner, C.; Kotovskiy, N.; Kraus, I.; Lestinsky, M.; Litvinov, S.; Nolden, F.; Reiter, A. [GSI Helmholtzzentrum für Schwerionenforschung (Germany); and others

    2017-11-15

    Once operational, CRYRING@ESR will store and decelerate ions delivered by the experimental storage ring ESR at energies well below those of ESR. In addition to that, CRYRING@ESR has an electron cooler operating with an ultracold electron beam, allowing to provide cooled ion beams for precision experiments. These ions will be delivered to a broad range of experiments presently in preparation; either in-ring or extracted to a dedicated beamline for experiments. An overview and status report of the installation and commissioning of the CRYRING-@ESR storage ring for highly charged ions at the GSI Helmholtzzentrum für Schwerionenforschung is presented. The installation of this storage ring started in 2014 and was completing end of 2016, when this publication was written.

  9. Screening of irradiated food using ESR measurement of paper

    International Nuclear Information System (INIS)

    Goto, Michiko; Yamazaki, Masao

    2005-01-01

    As paper has high content of cellulose, sensibility of ESR measurements of paper should be high. We examined stability of ESR signals in irradiated recycled copying paper, and estimated the possibility to utilize ESR measurement of paper for the detection of irradiated food. Cellulose radicals in paper irradiated at 1kGy and stored at 40degC in water was detected for 20 days. Cellulose radicals in irradiated paper stored at 90degC in water were more stable than that stored in air. ESR measurements of 50mg paper are simple and easy, so ESR measurement of rapping paper or corrugated box is good screening method for the detection of irradiated food. (author)

  10. Establishment of estrogen receptor 1 (ESR1)-knockout medaka: ESR1 is dispensable for sexual development and reproduction in medaka, Oryzias latipes.

    Science.gov (United States)

    Tohyama, Saki; Ogino, Yukiko; Lange, Anke; Myosho, Taijun; Kobayashi, Tohru; Hirano, Yu; Yamada, Gen; Sato, Tomomi; Tatarazako, Norihisa; Tyler, Charles R; Iguchi, Taisen; Miyagawa, Shinichi

    2017-08-01

    Estrogens play fundamental roles in regulating reproductive activities and they act through estrogen receptor (ESR) in all vertebrates. Most vertebrates have two ESR subtypes (ESR1 and ESR2), whereas teleost fish have at least three (Esr1, Esr2a and Esr2b). Intricate functionalization has been suggested among the Esr subtypes, but to date, distinct roles of Esr have been characterized in only a limited number of species. Study of loss-of-function in animal models is a powerful tool for application to understanding vertebrate reproductive biology. In the current study, we established esr1 knockout (KO) medaka using a TALEN approach and examined the effects of Esr1 ablation. Unexpectedly, esr1 KO medaka did not show any significant defects in their gonadal development or in their sexual characteristics. Neither male or female esr1 KO medaka exhibited any significant changes in sexual differentiation or reproductive activity compared with wild type controls. Interestingly, however, estrogen-induced vitellogenin gene expression, an estrogen-responsive biomarker in fish, was limited in the liver of esr1 KO males. Our findings, in contrast to mammals, indicate that Esr1 is dispensable for normal development and reproduction in medaka. We thus provide an evidence for estrogen receptor functionalization between mammals and fish. Our findings will also benefit interpretation of studies into the toxicological effects of estrogenic chemicals in fish. © 2017 Japanese Society of Developmental Biologists.

  11. ESR Studies and Dating of Egyptian Gypsum at Ras Mala'ab, Sinai, Egypt

    International Nuclear Information System (INIS)

    Abdel-Monem, A. A.; Abdei-Razek, Y. A.; Rasheed, N. M.; Hassan, G.M.; Eissa, H.M.; El-Morsy, M.

    2007-01-01

    A gypsum sample from the famous gypsum-anhydrite evaporitic deposit composing the Ras Mala'ab Formation, Upper Miocene, occurring at Ras Mala'ab, on the east coast of the Gulf of Suez, was subjected to (ESR) dosimetric studies. Also, (ESR) was used to date the formation or most recent recrystallization of that gypsum. The gypsum derivative (ESR) spectrum is characterized by the large broad Fe 2+ signal (g=2.50) and HF-sixtet Mn 2+ signals. Only the characteristic gypsum signal (G l, g=2.0040) was detected between the third and fourth lines of the HF-Mn 2+ which is attributed to the electron-center SO 3 - . This signal was sensitive to artificial γ-irradiation and showed significant enhancement using a γ-dose of 550 Gy. Also, the signal was very stable up to 400 o C. The gypsum sample with a total dose (TD) of 1500 Gy, determined graphically by extrapolating the linear relationship between defect concentration and the artificial γ-doses for (G l, g=2.0040) and an annual dose (D) due to cosmic rays (0.3 mGy), yielded an age of 5.00 Ma. This could mean the age of formation or latest recrystallization of this gypsum deposit. The geologic age assignment of the Ras Mala'ab Group including the evaporitic gypsum unit, is Middle to Late Miocene. It is directly overlain by the Pliocene elastics at the locality of Ras Mala'ab. This might suggest that these evaporitic gypsum facies represent the top of the Miocene in the Gulf of Suez area, since the Miocene-Pliocene boundary is now put at 5.00-5.50 Ma ago. Therefore, the ESR age of the Ras Mala'ab gypsum is consistent with the geologic age assignment

  12. Interpretation of cw-ESR spectra of p-methyl-thio-phenyl-nitronyl nitroxide in a nematic liquid crystalline phase.

    Science.gov (United States)

    Collauto, Alberto; Zerbetto, Mirco; Brustolon, Marina; Polimeno, Antonino; Caneschi, Andrea; Gatteschi, Dante

    2012-03-07

    In this paper we report on the characterization by continuous wave electron spin resonance spectroscopy (cw-ESR) of a nitronyl nitroxide radical in a nematic phase. A detailed analysis is performed by exploiting an innovative modeling strategy alternative to the usual spectral simulation approach: most of the molecular parameters needed to calculate the spectrum are evaluated a priori and the ESR spectrum is obtained by direct application of the stochastic Liouville equation. Allowing a limited set of fitting parameters it is possible to reproduce satisfactorily ESR spectra in the temperature range 260 K-340 K including the nematic-to-isotropic phase transition (325.1 K). Our results open the way to a more quantitative understanding of the ordering and mobility of nitronyl nitroxide radicals in nanostructured environments.

  13. A Kidney Graft Survival Calculator that Accounts for Mismatches in Age, Sex, HLA, and Body Size.

    Science.gov (United States)

    Ashby, Valarie B; Leichtman, Alan B; Rees, Michael A; Song, Peter X-K; Bray, Mathieu; Wang, Wen; Kalbfleisch, John D

    2017-07-07

    Outcomes for transplants from living unrelated donors are of particular interest in kidney paired donation (KPD) programs where exchanges can be arranged between incompatible donor-recipient pairs or chains created from nondirected/altruistic donors. Using Scientific Registry of Transplant Recipients data, we analyzed 232,705 recipients of kidney-alone transplants from 1998 to 2012. Graft failure rates were estimated using Cox models for recipients of kidney transplants from living unrelated, living related, and deceased donors. Models were adjusted for year of transplant and donor and recipient characteristics, with particular attention to mismatches in age, sex, human leukocyte antigens (HLA), body size, and weight. The dependence of graft failure on increasing donor age was less pronounced for living-donor than for deceased-donor transplants. Male donor-to-male recipient transplants had lower graft failure, particularly better than female to male (5%-13% lower risk). HLA mismatch was important in all donor types. Obesity of both the recipient (8%-18% higher risk) and donor (5%-11% higher risk) was associated with higher graft loss, as were donor-recipient weight ratios of transplants where both parties were of similar weight (9%-12% higher risk). These models are used to create a calculator of estimated graft survival for living donors. This calculator provides useful information to donors, candidates, and physicians of estimated outcomes and potentially in allowing candidates to choose among several living donors. It may also help inform candidates with compatible donors on the advisability of joining a KPD program. Copyright © 2017 by the American Society of Nephrology.

  14. ESRS guidelines for software safety reviews. Reference document for the organization and conduct of Engineering Safety Review Services (ESRS) on software important to safety in nuclear power plants

    International Nuclear Information System (INIS)

    2000-01-01

    The IAEA provides safety review services to assist Member States in the application of safety standards and, in particular, to evaluate and facilitate improvements in nuclear power plant safety performance. Complementary to the Operational Safety Review Team (OSART) and the International Regulatory Review Team (IRRT) services are the Engineering Safety Review Services (ESRS), which include reviews of siting, external events and structural safety, design safety, fire safety, ageing management and software safety. Software is of increasing importance to safety in nuclear power plants as the use of computer based equipment and systems, controlled by software, is increasing in new and older plants. Computer based devices are used in both safety related applications (such as process control and monitoring) and safety critical applications (such as reactor protection). Their dependability can only be ensured if a systematic, fully documented and reviewable engineering process is used. The ESRS on software safety are designed to assist a nuclear power plant or a regulatory body of a Member State in the review of documentation relating to the development, application and safety assessment of software embedded in computer based systems important to safety in nuclear power plants. The software safety reviews can be tailored to the specific needs of the requesting organization. Examples of such reviews are: project planning reviews, reviews of specific issues and reviews prior final acceptance. This report gives information on the possible scope of ESRS software safety reviews and guidance on the organization and conduct of the reviews. It is aimed at Member States considering these reviews and IAEA staff and external experts performing the reviews. The ESRS software safety reviews evaluate the degree to which software documents show that the development process and the final product conform to international standards, guidelines and current practices. Recommendations are

  15. ESR dating of glacial tills of Baishuihe river on the southern slope of Lenglongling in the eastern part of Qilian Mountains

    International Nuclear Information System (INIS)

    Zhao Jingdong; Zhou Shangzhe; Shi Zhengtao; Zhang Shiqiang; Cui Jianxin; Xu Liubing; Ye Yuguang

    2001-01-01

    Baishuihe River is a tributary of Datong River, located on the southern slope of Lenglongling in the eastern part of the Qilian Mountains. An integral end till remains at the entrance of the valley. There is a push moraine in the till section. Three samples were derived from this section. Two samples were collected at the front of the push moraine and another sample (near the push moraine) collected from the rear of it, ESR ages were 73.0 ka, 55.8 ka, 36.7 ka respectively. The ESR ages being consistent with the relationship of deposits. The ages before the push moraine were correlated to the deep-sea oxygen isotope stage 4 within 10% deviation. Based on them, the authors could determine the till before the push moraine were formed in the early period of Last Glaciation. Comparing the ESR age of LS-5 with the results of previous 14 C, the authors found that the ESR age was older. Through the error correction, the authors concluded: the existing push moraine distorted the till around it, mixing the super-glacial till, englacial till and subglacial till together. The authors considered: the main reason influencing the ESR age was that the englacial till and the subglacial till were not exposed completely before they deposited. Although the result of LS-5 was older than the previous 14 C, combining the ESR age and the relationship of deposit and the existing 14 C ages, the authors inferred that the rear of the push moraine was deposited in the later period of the last glaciation and was correlated to the deep-sea oxygen isotope stage 2. At the same time, the conclusion once again proved the previous scholars' conclusion. This shows the ESR technique may be applied to glacial till dating

  16. Luminescence and ESR properties of Brazilian feldspars

    International Nuclear Information System (INIS)

    Bitencourt, J.F.S.; Silva, D.M.; Silva, P.H.; Kinoshita, A.; Munita, C.S.; Tatumi, S.H.

    2006-01-01

    The IRSL and TL responses of three different feldspar crystals have been analysed. TL measurements were taken in the ultraviolet UV (290-370nm) and the visible VIS (340-610nm) regions of the spectrum. For the UV region and for a natural sample, peaks were observed at 283, 287 and 310 deg. C for grey, white and pink crystals, respectively. For samples irradiated after prior preheating, it was noted that TL peaks occurred at about 200 deg. C for all the samples; irradiation with high doses above 500Gy induced the formation of one additional peak at 170 deg. C. The VIS region results were similar to those for the UV. ESR experiments have been developed to verify the influence of radiation and heat treatments on the centres and preliminary results showed great variation in the intensities of [TiO 4 ] - , Al-O - -Al and Fe 3+ centres

  17. Electron cooling experiments at the ESR

    International Nuclear Information System (INIS)

    Steck, M.; Beller, P.; Beckert, K.; Franzke, B.; Nolden, F.

    2004-01-01

    The properties of electron cooled beams of highly charged ions have been studied at the ESR. New experiments using a beam scraper to determine the transverse beam size provide the beam parameters in the intrabeam scattering dominated intensity regime, but also at very low intensity when the ion beam enters into an ultra-cold state. Extremely low values of longitudinal and transverse beam temperature on the order of meV were achieved for less than 1000 stored ions. An experiment with bunched ultra-cold beam showed a limit of the line density which agrees with the one observed for coasting beams. Cooling of decelerated ions at a minimum energy of 3 MeV/u has been demonstrated recently

  18. Cooled heavy ion beams at the ESR

    International Nuclear Information System (INIS)

    Steck, M.; Beckert, K.; Bosch, F.; Eickhoff, H.; Franzke, B.; Klepper, O.; Nolden, F.; Reich, H.; Schlitt, B.; Spaedtke, P.; Winkler, T.

    1996-01-01

    The storage ring ESR has been used in various operational modes for experiments with electron cooled heavy ion beams. Besides the standard storage mode including injection and beam accumulation the deceleration of highly charged ions has been demonstrated. Beams of highly charged ions have been injected and accumulated and finally decelerated to a minimum energy of 50 MeV/u. An ultraslow extraction method using charge changing processes is now also available for cooled beams of highly charged ions. For in ring experiments the internal gas jet and the cold electron beam of the cooling system are applied as targets. High precision mass spectrometry by Schottky noise detection has been demonstrated. Operation at transition energy has been achieved with cooled beams opening the field for experiments which require an isochronous revolution of the ions. (orig.)

  19. Criticality accident dosimetry with ESR spectroscopy.

    Science.gov (United States)

    d'Errico, F; Fattibene, P; Onori, S; Pantaloni, M

    1996-01-01

    The suitability of the ESR alanine and sugar detectors for criticality accident dosimetry was experimentally investigated during an intercomparison of dosimetry techniques. Tests were performed irradiating detectors both free-in-air and on-phantom during controlled critcality excursions at the SILENE reactor in Valduc, France. Several grays of absorbed dose were imparted in neutron gamma-ray fields of various relative intensities and spectral distributions. Analysed results confirmed the potential of these systems which can immediately provide an acute dose assessment with an average underestimate of 30%in the various fields. This performance allows for the screening of severely exposed individuals and meets the IAEA recommendations on the early estimate of accident absorbed doses.

  20. SDSL-ESR-based protein structure characterization.

    Science.gov (United States)

    Strancar, Janez; Kavalenka, Aleh; Urbancic, Iztok; Ljubetic, Ajasja; Hemminga, Marcus A

    2010-03-01

    As proteins are key molecules in living cells, knowledge about their structure can provide important insights and applications in science, biotechnology, and medicine. However, many protein structures are still a big challenge for existing high-resolution structure-determination methods, as can be seen in the number of protein structures published in the Protein Data Bank. This is especially the case for less-ordered, more hydrophobic and more flexible protein systems. The lack of efficient methods for structure determination calls for urgent development of a new class of biophysical techniques. This work attempts to address this problem with a novel combination of site-directed spin labelling electron spin resonance spectroscopy (SDSL-ESR) and protein structure modelling, which is coupled by restriction of the conformational spaces of the amino acid side chains. Comparison of the application to four different protein systems enables us to generalize the new method and to establish a general procedure for determination of protein structure.

  1. TL and ESR based identification of gamma-irradiated frozen fish using different hydrolysis techniques

    Science.gov (United States)

    Ahn, Jae-Jun; Akram, Kashif; Shahbaz, Hafiz Muhammad; Kwon, Joong-Ho

    2014-12-01

    Frozen fish fillets (walleye Pollack and Japanese Spanish mackerel) were selected as samples for irradiation (0-10 kGy) detection trials using different hydrolysis methods. Photostimulated luminescence (PSL)-based screening analysis for gamma-irradiated frozen fillets showed low sensitivity due to limited silicate mineral contents on the samples. Same limitations were found in the thermoluminescence (TL) analysis on mineral samples isolated by density separation method. However, acid (HCl) and alkali (KOH) hydrolysis methods were effective in getting enough minerals to carry out TL analysis, which was reconfirmed through the normalization step by calculating the TL ratios (TL1/TL2). For improved electron spin resonance (ESR) analysis, alkali and enzyme (alcalase) hydrolysis methods were compared in separating minute-bone fractions. The enzymatic method provided more clear radiation-specific hydroxyapatite radicals than that of the alkaline method. Different hydrolysis methods could extend the application of TL and ESR techniques in identifying the irradiation history of frozen fish fillets.

  2. Radicals in DNA as seen by ESR spectroscopy

    International Nuclear Information System (INIS)

    Symons, M.C.R.

    1997-01-01

    This is a review of ESR studies, mainly of DNA systems, after exposure to ionising radiation at low temperatures. Under this conditions 'direct' damage is of major significance, and ESR evidence for the concept of the initial formation of electron-gain and electron-loss centers localised within DNA bases, and deeply trapped by proton-gain and loss, will be discussed. It is stressed that 'negative' evidence, showing that various phosphate and sugar centred radicals are not detected, is of major importance since the ESR 'fingerprints' of base-radicals are relatively ill defined. (author)

  3. ESR measurements and the detection of radiosterilization of drugs

    International Nuclear Information System (INIS)

    Gibella, M.; Crucq, A.S.; Tilquin, B.

    1993-01-01

    The ESR spectrum of trapped radicals in irradiated solid antibiotics could permit the detection of the radiosterilization. The ESR signal is detected only after radiolysis; at room temperature, this ESR spectrum is observable for a few hours or until several years. The rate of the metathesis reactions can be fast or very slow, the reaction path is unknown,. However, in many cases, the polycrystalline solid phase exhibits its ability to keep radicals for a long period of time and the detection of the radiolysis is possible during this period. 10 figs., 1 tab

  4. Ribavirin restores ESR1 gene expression and tamoxifen sensitivity in ESR1 negative breast cancer cell lines

    Directory of Open Access Journals (Sweden)

    Sappok Anne

    2011-12-01

    Full Text Available Abstract Tumor growth is estrogen independent in approximately one-third of all breast cancers, which makes these patients unresponsive to hormonal treatment. This unresponsiveness to hormonal treatment may be explained through the absence of the estrogen receptor alpha (ESR1. The ESR1 gene re-expression through epigenetic modulators such as DNA methyltransferase inhibitors and/or histone deacetylase inhibitors restores tamoxifen sensitivity in ESR1 negative breast cancer cell lines and opens new treatment horizons in patients who were previously associated with a poor prognosis. In the study presented herein, we tested the ability of ribavirin, which shares some structural similarities with the DNA-methyltransferase inhibitor 5-azacytidine and which is widely known as an anti-viral agent in the treatment of hepatitis C, to restore ESR1 gene re-expression in ESR1 negative breast cancer cell lines. In our study we identified ribavirin to restore ESR1 gene re-expression alone and even more in combination with suberoylanilide hydroxamic acid (SAHA - up to 276 fold induction. Ribavirin and analogs could pave the way to novel translational research projects that aim to restore ESR1 gene re-expression and thus the susceptibility to tamoxifen-based endocrine treatment strategies.

  5. ESR dating of an ancient goat tooth from Nuoro, Sardinia, Italy

    International Nuclear Information System (INIS)

    Baffa, O.; Kinoshita, A.; Figueiredo, A. M. G.; Brunetti, A.; Ginesu, S.

    2006-01-01

    The dating of fossil teeth of an ancient goat (Nesogoral melonii) using the electron spin resonance (ESR) technique is reported. This animal was found in the fossiliferous site at Orosei (Nuoro, Sardinia, Italy) and was endemic in the region. Molar teeth were cleaned and enamel was completely removed from dentine. Enamel was irradiated with a 60 Co gamma source and measured with an ESR spectrometer (X-band) to obtain the signal vs. dose curve and fitted with an exponential function. The archaeological dose obtained by the fitting was 211 ± 34 Gy. Uranium and thorium concentrations were determined by neutron activation analysis. With the software ROSY the age estimates were 195 ± 30 ky for early uptake, 247 ± 40 ky for linear uptake and 243 ± 40 ky for a combination of uptake processes. (authors)

  6. ESR dating of geyserites from intermittent geyser sites on the Tibetan Plateau

    International Nuclear Information System (INIS)

    Chen, Y.; Feng, J.

    1993-01-01

    Thirteen geyserite samples obtained from two intermittent geyser sites on the Tibetan Plateau were dated by the ESR technique. ESR spectra of geyserite display two sets of signals. One is a set of triplet signals assigned to organic radical X-C-radicalH 2 by Griffiths et al. (1982), another is a mixed signal produced from E'-type defect centres of the silica minerals in geyserite, such as opal, cristobalite, tridymite and quartz. The ages obtained using the mixed E'-type signal are approximately consistent with the stratigraphy and the silica diagenetic sequence. The correlation between the thermal stability of E'-type signal and the mineral association of geyserite was investigated by annealing experiments. (author)

  7. Relationship of white blood cell counts, haemoglobin and ESR with IHD

    International Nuclear Information System (INIS)

    Shahzad, F.; Shahzad Tawwab, S.; Abbas, A.

    2009-01-01

    To find any association of white blood cells, haemoglobin and ESR with ischemic heart disease in high risk native population. Methodology: The study included 93 male patients with Ischemic heart disease, between 40 and 60 years of age; 96 age and gender matched subjects. All study participants were non-diabetics. Complete blood cells count, haemoglobin and ESR levels were compared between the patient and control groups. Results: Total leukocyte counts along with neutrophils were significantly higher in the test group compared to the control population (p<0.001) and lymphocytes were significantly lower (p<0.001) in the patient group as compared to the control group. Haemoglobin levels were significantly lower (p<0.001) and ESR was higher (p=0.030) in the patient group as compared to the control group. Conclusion: Although, our findings of the study variables extend previous reports, the prevalence and prognostic importance of theses variables in IHD should be assessed in future experimental studies. These parameters could be important in public health because they are routinely measured by clinicians and may be helpful to predict the risk of future and secondary ischemic events in a high risk population. (author)

  8. ESR studies on CaCO3 of deep-sea sediments

    International Nuclear Information System (INIS)

    Mangini, A.; Segl, M.; Schmitz, W.

    1983-01-01

    We have measured depth profiles of the ESR signals on the calcite fraction in 3 deep-sea sediments with a well-established age stratigraphy and CaCO 3 contents around 50 percent. In the ESR spectra of the foraminifera we observe 3 lines (A, B and C, following Ikeya's notation) two of which (A and C) were analysed as depth profiles. The A signal displays a continuous increase with depth over the time periods covered by the sediment cores of 400,000 and 800,000 a B.P. This suggests that a) the lifetime of the electron traps is long compared to these time intervals and b) the traps as yet unsaturated with electrons. Despite our present ignorance of the nature of the traps, these results might indicate the possible future applicability of ESR as a tool for dating sediment cores over time periods up to 1 Ma. The more prominent C signal displays a linear increase over time periods of 100,000 to 200,000 a. Beyond this age we find an overall increase, on which is superimposed short-term noise of similar amplitude that is unrelated to the 232 Th and CaCO 3 contents. (author)

  9. ESR1 Gene Polymorphisms and Prostate Cancer Risk: A HuGE Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Yu-Mei Wang

    Full Text Available Many published data on the association between single nucleotide polymorphisms (SNPs in the ESR1 gene and prostate cancer susceptibility are inconclusive. The aim of this Human Genome Epidemiology (HuGE review and meta-analysis is to derive a more precise estimation of this relationship.A literature search of PubMed, Embase, Web of Science and Chinese Biomedical (CBM databases was conducted from their inception through July 1st, 2012. Crude odds ratios (ORs with 95% confidence intervals (CIs were calculated to assess the strength of association.Twelve case-control studies were included with a total 2,165 prostate cancer cases and 3,361 healthy controls. When all the eligible studies were pooled into the meta-analysis, ESR1 PvuII (C>T and XbaI (A>G polymorphisms showed no association with the risk of prostate cancer. However, in the stratified analyses based on ethnicity and country, the results indicated that ESR1 PvuII (C>T polymorphism was significantly associated with increased risk of prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI (A>G polymorphism may significantly increase the risk of prostate cancer among American population. Furthermore, we also performed a pooled analysis for all eligible case-control studies to explore the role of codon 10 (T>C, codon 325 (C>G, codon 594 (G>A and +261G>C polymorphisms in prostate cancer risk. Nevertheless, no significant associations between these polymorphisms and the risk of prostate cancer were observed.Results from the current meta-analysis indicate that ESR1 PvuII (C>T polymorphism may be a risk factor for prostate cancer among Asian populations, especially among Indian population; while ESR1 XbaI (A>G polymorphism may increase the risk of prostate cancer among American population.

  10. Erythrocyte Sedimentation Rate (ESR): MedlinePlus Lab Test Information

    Science.gov (United States)

    ... K. Brunner & Suddarth's Handbook of Laboratory and Diagnostic Tests. 2 nd Ed, Kindle. Philadelphia: Wolters Kluwer Health, Lippincott Williams & Wilkins; c2014. Erythrocyte Sedimentation Rate (ESR); p. 267– ...

  11. Modeling membrane protein structure through site-directed ESR spectroscopy

    NARCIS (Netherlands)

    Kavalenka, A.A.

    2009-01-01

    Site-directed spin labeling (SDSL) electron spin resonance (ESR) spectroscopy is a
    relatively new biophysical tool for obtaining structural information about proteins. This
    thesis presents a novel approach, based on powerful spectral analysis techniques (multicomponent
    spectral

  12. Irradiation detection of coffee mate by electron spin resonance (ESR)

    Energy Technology Data Exchange (ETDEWEB)

    Ozsayin, Fulya [Physics Engineering Department, Hacettepe University, 06800 Ankara (Turkey); Polat, Mustafa, E-mail: polat@hacettepe.edu.t [Physics Engineering Department, Hacettepe University, 06800 Ankara (Turkey)

    2011-06-15

    Un-irradiated coffee mate samples do not exhibit any ESR signal. However, the samples exposed to UV and gamma radiation exhibit an ESR singlet and a large unresolved ESR signal, respectively. The dose-response curves of the samples exposed to UV and gamma radiations were found to be described well by an exponential and linear functions, respectively. Variable temperature and fading studies at room temperature showed that the radiation-induced radicals in coffee mate sample are very sensitive to temperature. The discrimination between un-irradiated and irradiated coffee mate samples can be done just comparing their ESR spectra. However, determination of the radiation dose received by the sample cannot be possible because of the fast decay of signal intensity at room temperature.

  13. HPLC-ESR techniques for detection of complex trapped radicals

    International Nuclear Information System (INIS)

    Tu Tiecheng; Dong Jirong; Lin Nianyun; Xie Leidong; Liu Rengzhong

    1992-01-01

    High performance liquid chromatography (HPLC) and ESR combined examination of radical species is an advanced techniques for separation and identification of complex radical species. At SRCL, Waters 990 HPLC has been used to separate the complex trapped radicals and Varian E-112 ESR spectrometer to record the spectra of single trapped radicals after HPLC separation. The advantages of the combined techniques are described as bellow: HPLC is used to separate the long-lived complex trapped radicals derived from reaction of short-lived radicals with spin trap. ESR spectra from single trapped radicals, obtained following HPLC separation of complex trapped radicals, are recorded one by one and well resolved. The structures of short-lived radicals can be inferred from the ESR spectra of the long-lived trapped radicals

  14. The influence of non-radiation induced ESR background signal from paraffin-alanine probes for dosimetry in the radiotherapy dose range

    International Nuclear Information System (INIS)

    Wieser, A.; Lettau, C.; Fill, U.; Regulla, D.F.

    1993-01-01

    The yield of radicals induced by ionizing radiation in the amino acid alanine and its quantification by ESR spectroscopy has proven excellent reproducibility. Those radicals trapped in the crystal lattice are prevented from recombination providing a thermally very stable system. This allows alanine to be applied as a transfer dosemeter. With paraffin-alanine probes ESR dosimetry can be performed with a standard deviation of ± 0.5% in the dose range from 20 Gy up to 100 kGy. At 1 Gy dose level the error increases to ± 6%. This dose level is three orders of magnitude higher than the calculated detection threshold for alanine with modern X-band ESR spectrometers. It was found that the poor standard deviation at the 1 Gy dose level, is not mainly produced by a bad signal-to-noise ratio but by a variable non-radiation induced ESR background signal from the alanine probes within a batch. In the present study the main sources of error for ESR dosimetry in the dose range below 20 Gy were analyzed. The influences of the production process, UV light and humidity upon the ESR background signal from paraffin-alanine probes were investigated. Measurements are shown indicating a second stable structure of the alanine radical at room temperature. (author)

  15. ESR analysis of irradiated red peppers and commercial red peppers in Japan

    International Nuclear Information System (INIS)

    Kameya, Hiromi; Ukai, Mitsuko

    2011-01-01

    ESR analysis of γ-ray irradiated and being treated with different processing red pepper was studied. All the red peppers were commercial expect irradiated one. Processing treatment of red pepper was sun drying, mechanical processing (heating sterilization and powdering treatment). All the samples were weighted and analyzed. The ESR spectrum of the red pepper is composed of a singlet at g=2.00. This signal was originated from organic free radical. It is suggested the effect of heating treatment on the radical formation is not so large and powdering treatment will promote the radical formation of red pepper. ESR singlet signal of the irradiated red pepper showed the large signal intensity and the dose-dependence. The singlet signal intensity of irradiated powder sample showed the almost same value as compared with that of the powder sample with heating treatment. Relaxation times (T 1 and T 2 ) of the singlet signal were calculated. The relaxation behavior and relaxation times of the irradiated sample were different from that of the non-irradiated sample. The value of T 1 , the spin lattice relaxation time, of irradiated sample was increased and T 2 , the spin-spin relaxation time, of irradiated sample was decreased. We concluded that the radical formation of the red pepper is mainly depended on the powdering treatment and irradiation. (author)

  16. TL and ESR based identification of gamma-irradiated frozen fish using different hydrolysis techniques

    International Nuclear Information System (INIS)

    Ahn, Jae-Jun; Akram, Kashif; Shahbaz, Hafiz Muhammad; Kwon, Joong-Ho

    2014-01-01

    Frozen fish fillets (walleye Pollack and Japanese Spanish mackerel) were selected as samples for irradiation (0–10 kGy) detection trials using different hydrolysis methods. Photostimulated luminescence (PSL)-based screening analysis for gamma-irradiated frozen fillets showed low sensitivity due to limited silicate mineral contents on the samples. Same limitations were found in the thermoluminescence (TL) analysis on mineral samples isolated by density separation method. However, acid (HCl) and alkali (KOH) hydrolysis methods were effective in getting enough minerals to carry out TL analysis, which was reconfirmed through the normalization step by calculating the TL ratios (TL 1 /TL 2 ). For improved electron spin resonance (ESR) analysis, alkali and enzyme (alcalase) hydrolysis methods were compared in separating minute-bone fractions. The enzymatic method provided more clear radiation-specific hydroxyapatite radicals than that of the alkaline method. Different hydrolysis methods could extend the application of TL and ESR techniques in identifying the irradiation history of frozen fish fillets. - Highlights: • Irradiation has potential to improve hygienic quality of raw and processed seafood. • Detection of irradiated food is important to enforce the applied regulations. • Different techniques were compared to separate silicate minerals from frozen fish. • Limitations were observed in TL analysis on minerals isolated by density separation. • Hydrolysis methods provided more clear identification using TL and ESR techniques

  17. Lactose and ''tris'' lyoluminescence dosimetry systems and ESR correlation studies

    International Nuclear Information System (INIS)

    Oommen, I.K.; Nambi, K.S.V.; Sengupta, S.; Rao, T.K.G.; Ravikumar, M.

    1989-01-01

    Lyoluminescence (LL) dosimeters have been developed using lactose monohydrate (disaccharide) and tris(hydroxymethyl)aminomethane (''Tris'') systems and attempts have been made to understand the LL mechanism through ESR correlation studies. Tris LL dosimeter has a γ-ray sensitivity with a linear response in the absorbed-dose range 0.05-200 Gy (5-2 x 10 4 rad), while the lactose response extends to a higher range from 1 to 10 4 Gy (10 2 -10 6 rad). The LL output of lactose and Tris did not show any appreciable decay for a period of 6 months after irradiation. ESR measurements show that free-radical concentration in both the systems increases with γ-ray dose in the range 10 2 -10 5 Gy. The minimum dose required to measure the radiation-induced ESR signal for Tris is ∼ 500 Gy, the dose at which the LL output saturates, while lactose shows a radiation-induced ESR signal right at the minimum dose where LL could be detected. The estimated spin density on the radical carbon atom is 0.7. ESR signal stabilities of lactose and Tris were also studied. Lactose did not show any appreciable ESR decay for a period of 3 months after irradiation, while, for Tris, one of the radicals showed a decay of 45% for the same period. (author)

  18. Dosimetry of blood irradiation using an alanine/ESR dosimeter

    International Nuclear Information System (INIS)

    Chen, F.; Covas, D.T.; Baffa, O.

    2001-01-01

    A batch of 80 DL-alanine dosimeters was supplied to Hemocentro of the Hospital and Clinics of Faculdade de Medicina de Ribeirao Preto (HC-FMRP) SP, Brazil for the purpose of quality control of the radiation dose delivered to blood bags. The irradiation was made using two (40x40) cm 2 parallel opposed radiation fields each with 80 cm of source to surface distance in the Radiotherapy Section of HC-FMRP with the 60 Co teletherapy unit. The calculated radiation absorbed dose at the center of the box was 20 Gy. The dosimeter readings were performed using a Varian E-4 ESR Spectrometer operating in X-band. For the 80 dosimeters and over the irradiation volume throughout a blood bag, the minimum and maximum doses were 14 and 23 Gy, respectively. The mean dose was (18±2) Gy (1σ), and the coefficient of variability was 11.1%. Alanine dosimeters demonstrated easy handling, good precision and adequate sensitivity for this application

  19. Basic ESR studies on recent corals

    Science.gov (United States)

    Walther, Ralf; Barabas, Michael; Mangini, Augusto

    Experiments on recent corals ( Acropora palmata, Barbados) were carried out to study the dating relevant properties of the characteristic ESR signals. Highly resolved signal growth curves (55 aliquots of a sieve fraction 125-250 μm) were obtained by γ-irradiation in small steps up to 20 kGy. The signal growth curve of the 'dating signal' at g = 2.0006 can only be approximated by a single exponential saturation function in a certain dose range. Thus, ADs derived with this function tend to be overestimated. A better analytical description by two different functions was tested. Isothermal annealing experiments were carried out at various temperatures before and after irradiation with a definite γ-dose respectively. The thermal decay of the dating signal is not 1st order. Furthermore, the decay process is strongly influenced by the decay of the traps themselves. The behaviour of the signals at g = 2.0057 and g = 2.0031 was compared with that of the dating signal. A surprising result was the growth of the signal at g = 2.0057 with γ-irradiation.

  20. Preliminary study on ESR dating of Hexian-Man and its fauna

    International Nuclear Information System (INIS)

    Huang Peihua; Zheng Lizhen; Quan Yucai; Liang Renyou; Xu Yunhua; Fang Yingsan; Fang Dusheng

    1995-01-01

    ESR dating results for samples of synchronous animal tooth with the skull of Hexian-Man in the lower part of the second layer show that the age of Hexian-Man is about 300(299.80) ka, corresponding to the late stage of Peiking-Man (the HIII skull of Peking-Man). The ages of Hexian-Man's Fauna are 150-300 ka, corresponding to those of the 2nd-3rd-4th layers of Peking-Man's Cave

  1. On the limits of using combined U-series/ESR method to date fossil teeth from two Early Pleistocene archaeological sites of the Orce area (Guadix-Baza basin, Spain)

    International Nuclear Information System (INIS)

    Duval, Mathieu; Falgueres, Christophe; Bahain, Jean-Jacques; Shao, Qingfeng; Grun, Rainer; Aubert, Maxime; Dolo, Jean-Michel; Agusti, Jordi; Martinez-Navarro, Bienvenido; Palmqvist, Paul; Toro-Moyano, Isidro

    2012-01-01

    The combined U-series/electron spin resonance (ESR) dating method was applied to nine teeth from two Early Pleistocene archaeological sites located in the Orce area (Guadix-Baza Basin, Southern Spain): Fuente Nueva-3 (FN-3) and Barranco Leon (BL). The combination of bio-stratigraphy and magneto-stratigraphy places both sites between the Olduvai and Jaramillo sub-chrons (1.78-1.07 Ma). Our results highlight the difficulty of dating such old sites and point out the limits of the combined U-series/ ESR dating method based on the US model. We identified several sources of uncertainties that may lead to inaccurate age estimates. Seven samples could not be dated because the dental tissues had ( 230 Th/ 234 U) activity ratios higher than equilibrium, indicating that uranium had probably leached from these tissues. It was however possible to calculate numerical estimates for two of the teeth, both from FN-3. One yielded a Middle Pleistocene age that seems to be strongly underestimated; the other provided an age of 1.19±0.21 Ma, in agreement with data obtained from independent methods. The latter result gives encouragement that there are samples that can be used for routine dating of old sites. (authors)

  2. ESR based detection method for irradiated dry fish, tomato soup powder and sweet-meats

    International Nuclear Information System (INIS)

    Brij Bhushan; Warrier, S.B.; Sharma, Arun

    2003-01-01

    Full text: Radiation Processing is increasingly being accepted as one of the most effective and economic method to treat agricultural and horticultural commodities for hygienization and disinfestation purposes and also in overcoming strict quarantine barriers in international trade. At present there is a growing concern about the presence of insecticides and pesticides and their residues in various foods, we consume. In view of this, irradiation, being a physical and cold process, emerges as the best bet towards having an uninterrupted supply of safe and quality food. The process has been endorsed as safe by several international and national bodies. A suitable detection method is however required to meet the basic requirements of consumers and law enforcement authorities, regulating the trade. Dried, sliced Pollack and File fishes were subjected to radiation dose of 4 kGy for elimination of coliforms and for improvement in quality standards during storage. Bones separated served as sample source for ESR based detection method of the radiation treatment. Bones with hard crystalline matrix served as trap for free radicals and facilitated evolution of an ESR based detection method. It showed a linear dose response curve at γ=2.0037, whereas, those from non-irradiated fish fillets failed to show any ESR signal. Re-irradiation helped in calculation of dose delivered to dried fishes. Sachets -containing tomato soup ingredients, including sugars exposed to 0.25 to 2 kGy gamma radiation doses for hygienization and quarantine purposes were used in the experiments. In-pack sugar crystals served as free radicals trap for ESR based detection method for radiation hygienized tomato soup powder. Similarly, it was observed that radiation hygienization of sugar bearing sweet-meats, like Peda (an evaporated milk preparation), Petha (a sugar syrup soaked vegetable preparation) and dry fruits like raisins could be detected using ESR. Suitable methodology was developed to detect

  3. Microscopic age determination of human skeletons including an unknown but calculable variable

    DEFF Research Database (Denmark)

    Wallin, Johan Albert; Tkocz, Izabella; Kristensen, Gustav

    1994-01-01

    estimation, which includes the covariance matrix of four single equation residuals, improves the accuracy of age determination. The standard deviation, however, of age prediction remains 12.58 years. An experimental split of the data was made in order to demonstrate that the use of subgroups gives a false...

  4. 49 CFR Appendix F to Part 227 - Calculations and Application of Age Corrections to Audiograms

    Science.gov (United States)

    2010-10-01

    ... 1 1 1 3 3 d. The difference represents the amount of hearing loss that may be attributed to aging in...) FEDERAL RAILROAD ADMINISTRATION, DEPARTMENT OF TRANSPORTATION OCCUPATIONAL NOISE EXPOSURE Pt. 227, App. F... the contribution of aging to the change in hearing level by adjusting the most recent audiogram. If...

  5. ESR studies of electron irradiated K3Ir(CN)6 in KCl single crystals

    International Nuclear Information System (INIS)

    Vugman, N.V.; Pinhal, N.M.

    1983-01-01

    ESR studies of KCl single crystals doped with small amounts of K 3 Ir(CN) 6 and submitted to a prolongued 2 MeV electron irradiation at room temperature reveal the presence of the [IR(CN) 5 Cl] 4- and [Ir(CN) 4 Cl 2 ] 4- new molecular species. Ligand spin densities and ligand field parameters are calculated from the experimental hyperfine and superhyperfine interactions and compared to previous data on the [Ir(CN) 5 ] 4- species. (Author) [pt

  6. Study on detection of electron beam irradiated food by ESR spectroscopy and comparison of the ESR spectrum of electron beams and γ-rays

    International Nuclear Information System (INIS)

    Li Weiming; Ha Yiming; Wang Feng

    2012-01-01

    The study was conducted to detect electron beam irradiated food by ESR spectroscopy. The white pepper powder, paprika powder, cumin powder and pistachios were used as test materials to study the feature changes of ESR spectrum and the relationship between ESR intensity and irradiation dose in different doses, the shape variation of ESR spectrum in γ-rays and electron beams in the same sample was also compared. The results showed that the ESR spectrum of 4 kinds of irradiated samples was obviously different before and after irradiation, the intensity of ESR signal increased with the increasing of the absorbed dose. The dose above 432 Gy could be detected in white pepper powder and pistachios, the dose above 875 Gy could be detected in paprika powder and cumin powder. The ESR intensity of all samples decreased during the storage time (200 d), even after 200 days the ESR method could also be used to detect whether or not the samples have been irradiated. The same dosage of y-rays and electron beams has no significant influence on the shape of ESR spectrum, however, the difference of irradiation mechanism caused slight impact on ESR intensity. The results could provide the technical basis for the application of ESR method in detecting electron beam irradiated food. (authors)

  7. Study on detection of electron beam irradiated food by ESR spectroscopy and comparison of the ESR spectrum of electron beams and γ-rays

    International Nuclear Information System (INIS)

    Li Weiming; Ha Yiming; Wang Feng

    2011-01-01

    The study was conducted to detect electron beam irradiated food by ESR spectroscopy. The white pepper powder, paprika powder, cumin powder and pistachios were used as test materials to study the feature changes of ESR spectrum and the relationship between ESR intensity and irradiation dose in different doses, the shape variation of ESR spectrum in γ-rays and electron beams in the same sample was also compared. The results showed that the ESR spectrum of 4 kinds of irradiated samples was obviously different before and after irradiation, the intensity of ESR signal increased with the increasing of the absorbed dose. The dose above 432 Gy could be detected in white pepper powder and pistachios, the dose above 875 Gy could be detected in paprika powder and cumin powder. The ESR intensity of all samples decreased during the storage time (200 d), even after 200 days the ESR method could also be used to detect whether or not the samples have been irradiated. The same dosage of γ-rays and electron beams has no significant influence on the shape of ESR spectrum, however, the difference of irradiation mechanism caused slight impact on ESR intensity. The results could provide the technical basis for the application of ESR method in detecting electron beam irradiated food. (authors)

  8. Free radicals in cellulose containing food detected by ESR

    International Nuclear Information System (INIS)

    Abe, Aika; Yogo, Satsuki; Ichii, Akane; Ukai, Mitsuko

    2003-01-01

    Using electron spin resonance (ESR) spectroscopy, we revealed three radical species in cellulose containing foods, pepper and green tea. These are commercially available in Japan. The representative ESR spectrum is composed of a sextet centered at g=2.0, a singlet at the same g-value, and a singlet at g=4.0. The first one is attributable to a signal with hyperfine (hf) interactions of Mn 2+ ion (hf constant: 7.4 mT). The second one is due to an organic free radical, the third one may be originated from Fe 3+ ion. The progressive saturation behavior (PSB) of the ESR at various microwave power levels were indicated different relaxation behaviors of in those radicals. Namely, the peak intensity of the organic free radical component decreases in a monotonic fashion, whereas the Mn 2+ and Fe 3+ ESR signals substantially keep constant. This reflects the evidence of three independent radical species. The ESR spectrum of the cellulose containing foods shows the same spectral feature irrespective of the tea or pepper. Upon gamma irradiation, a new pair of signals appeared. The PSB of the pair peaks after the irradiation showed a quite different as compared with the free radical centered at g=2. (author)

  9. ESR in a disordered network of nanographene sheets

    Science.gov (United States)

    Hagiwara, M.; Tsugeno, H.; Yamaguchi, H.; Joly, V. L. J.; Takai, K.; Enoki, T.

    2011-12-01

    Randomly networked nanographene sheets have been studied by electron spin resonance (ESR) technique at 20 GHz (K-band) and 35 GHz (Q-band). Nanographene has spin-polarized non-bonding π-electron states (edge-state spins) localized in the zigzag edge region. We have investigated the temperature dependence of an ESR signal of activated carbon fibers at two different microwave powers for each frequency. The signal intensity smoothly increases with decreasing temperature at any microwave power. The line width of ESR signal with a Lorentzian line shape decreases linearly upon cooling, and then increases steeply after taking a minimum at about 20 K irrespective of microwave power. The former is interpreted as the Korringa relation in the localized edge spins and conduction π carriers. The latter may be caused by inhomogeneous line broadening of the ESR signal from randomly distributed nanographene sheets with different sizes due to the suppression of electron hopping between nanographene sheets, i.e. electron localization. The discontinuous line broadening and the signal intensity drop at around 20 K reported in the previous X-band ESR at 1 μW were not observed, probably because of either higher microwave power than 1 μW or some amount of oxygen adsorption in our sample in the present study.

  10. [Relations between plasma-erythrocyte viscosity factors and ESR].

    Science.gov (United States)

    Cortinovis, A; Crippa, A; Crippa, M; Bosoni, T; Moratti, R

    1992-09-01

    The ESR is usually put in relationship: to the real density of the RBCs (erythrocytes) (difference between the RBC specific gravity and the plasma one), and to the resistance that the RBCs meet moving in a medium, which is due to the plasma viscosity and to the total external RBC surface. When the RBCs take shape of aggregates, their external surface is decreased and ESR increases. The most important plasma factor causing changes in ESR is the fibrinogen level followed by the plasma globulins and by the products arising from the tissue damage. The resistance that the RBCs meet moving in the plasma is well expressed by the measurement of the plasma-RBC viscosity considering that is inclusive of both factors that are the plasma viscosity and the external RBC surface. The plasma-RBC viscosity is the resultant of several factors: Fa = Fb - Fe - Fs - Fm, were: Fa is the resultant, Fb the attracting forces due to the proteic macromolecules, Fe the repulsing forces due the negative charges. Fs the repulsing forces due to the shear-stress, Fm the force which opposes itself against the surface tension of the aggregation; it depends on the RBC morphology and on the RBC rigidity. The ESR has been recently used like an index of the RBC aggregation. The Authors study the relationship between several hemorheological parameters and the ESR in infective and inflammatory processes.(ABSTRACT TRUNCATED AT 250 WORDS)

  11. U-Th/ESR combined dating of faunal remains from the Mousterian open site of Beauvais (France)

    International Nuclear Information System (INIS)

    Michel, V.; Masaoudi, H.; Falgueres, Ch.; Yokoyama, Y.; Locht, J.L.; Antoine, P.

    1999-01-01

    Faunal remains from the Beauvais open site 'La Justice' (Oise) are the subject of an U-Th dating (disequilibrium of the uranium chain) and an ESR dating (electronic spin resonance). This study was performed in order to identify the chronological situation of the Middle Paleolithic levels of this site located in the north of France, supposedly aged stage 4 after stratigraphic correlations. U-Th ages of bones and dentine are between 20 and 200 ka and are scattered; however, the combined ESR/U-Th ages of rhinoceros dental enamels are homogeneous and indicate that the archaeological levels were deposited between 60 to 40 ka. This period corresponds to the end of the oxygen isotopic stage 4 to the beginning of stage 3. (authors) stage 3. (authors)

  12. Analysis of ESR measurement parameters for detecting irradiated spices

    International Nuclear Information System (INIS)

    Kameya, Hiromi; Hagiwara, Shoji; Todoriki, Setsuko

    2015-01-01

    The side signals from irradiated cellulose radical are used for detecting irradiated spices with the electron spin resonance (ESR). The side signals are two signals observed on both sides of a singlet signal (g≒2.00) from organic free radicals. Since the intensities of the side signals are weak, if the width of the singlet signal is large, these signals are covered and cannot be observed. In this study, we analyzed ESR measurement parameters of seven kinds spices (oregano, basil, parsley, coriander, cumin, white pepper, and black pepper) that would lead to narrow width of the singlet signal for detecting side signals. The results were as follows: 4 mW microwave power for basil, parsley, oregano, coriander, and cumin, and 8 mW for white pepper and black pepper, while modulation amplitude of 4 G, time constant of 20 ms were determined to be the optimal ESR measurement parameters. (author)

  13. Dose determination by ESR in an accident, using cotton fabric

    International Nuclear Information System (INIS)

    Venkataramani, R.; Mehta, S.K.; Iyer, M.R.; Natarajan, V.; Sastry, M.D.

    1993-01-01

    Accidental exposure dose assessment by electron spin resonance (ESR) technique from the free radicals generated in a cotton handkerchief has been attempted in this investigation. The cotton handkerchief, a common material carried by individuals, was taken as the medium for free radical estimation. About 55 mg of the irradiated piece of cloth was loaded into a quartz tube and the dose dependence of the ESR signal at g = 2.0026 was measured at room temperature, using a Bruker ESP-300 ESR spectrometer in X-band (9.74 GHz). The intensity of this signal was found to be proportional to the dose in the range of 1-1000 Gy. The stability of the free radicals with time of storage was followed. Dependence of dose rate as well as the presence of water on the yield of free radicals were also investigated. (author) 5 refs.; 4 figs.; 2 tabs

  14. ESR dating: is it still an 'experimental' technique?

    International Nuclear Information System (INIS)

    Skinner, A.R.

    2000-01-01

    Nearly 25 years ago, Motoji Ikeya demonstrated the potential of ESR dating. From a single substance (stalagmitic carbonate) and a single site (Akiyoshi Cavern), the field has grown to include materials from all over the world and time periods from a few thousand years ago to several million years ago. A vigorous program of instrumentation development has increased the precision of measurements as well as opening up new ways of collecting and interpreting spectra. Yet there are still references to ESR dating as an 'experimental' technique, one which cannot be trusted to produce dates that are accurate or precise. This paper discusses areas for which this is true and suggests what should be done to convince skeptics. Other areas for which the evidence suggests that ESR is at least as reliable as 'standard' methods will also be covered

  15. The effect of utilising age and sex dependent factors for calculating detriment from medical irradiation

    International Nuclear Information System (INIS)

    Mettler, F.A.; Davis, M.; Moseley, R.D.; Kelsey, C.A.

    1986-01-01

    Proposals have been made for a quantity that can be used to estimate possible detriment from medical radiology better than the ICRP's collective effective dose equivalent. One such approach utilises age and sex dependent 'weighting' factors. The magnitude of the effect obtained by utilising such factors when applied to an actual population has not been previously assessed. When age and sex dependent weighting factors are applied to diagnostic medical radiology for all hospital examinations conducted in the United States in 1980, estimates of detriment are reduced by one-third. (author)

  16. An ESR study of radicals induced in irradiated fresh mango

    International Nuclear Information System (INIS)

    Kikuchi, Masahiro; Hussain, Mohammed S.; Morishita, Norio; Kobayashi, Yasuhiko; Ukai, Mitsuko; Shimoyama, Yuhei

    2009-01-01

    An electron spin resonance (ESR) spectroscopic study was performed on the radicals induced irradiated fresh mangoes. Fresh Philippine mangoes were irradiated by the γ-rays, lyophilized and powdered. The ESR spectrum of the dry specimen showed a strong main peak at g=2.004 and a pair of peaks at both magnetic fields of the main peak. The main peak detected from flesh and skin specimens faded away in a few days after the irradiation. On the other hand, the side peaks showed a well-defined dose response even 9 days after the irradiation. The side-peak is a useful mean to define the irradiation on fresh mangoes. (author)

  17. Alanine-ESR dosimetry for radiotherapy IAEA experience

    International Nuclear Information System (INIS)

    Mehta, K.; Girzikowsky, R.; )

    1997-01-01

    At present, the most commonly used transfer dosimeters for radiotherapy applications are TL dosemeters. They are being used for intercomparison between SSDLs (about 70) and the IAEA dosimetry laboratory. However, there are some undesirable characteristics of this dosimetry system. We have a study in progress at the IAEA to evaluate the alanine-ESR systems as an alternative to TLDs. There are several desirable qualities which make alanine an attractive dosemeter. Preliminary data suggest that the alanine-ESR dosimetry system has the potential to replace TLDs for intercomparison amongst SSDLs in the therapy-level dose regions. (Author)

  18. An ESR study of defects in irradiated hydroxyapatite

    International Nuclear Information System (INIS)

    Murata, T.; Shiraishi, K.; Ebina, Y.; Miki, T.

    1996-01-01

    Radiation-induced defects in synthetic hydroxyapatite (HAp) of six different origins have been investigated by electron spin resonance (ESR), X-ray diffraction (XRD), Raman scattering and IR measurements. The orthorhombic CO 2 - radicals were detected in almost all of the samples examined, but the isotropic CO 2 - was produced only in water-containing HAp with low crystallinity. The doublet signal due to H 0 was clearly detected in HAp with extreme calcium deficiency as compared to the stoichiometry. The results of ESR and FTIR suggest that water molecules in low crystalline HAp are not on the surface but embedded in the HAp crystalline lattice. (author)

  19. Photoluminescence and ESR of glasses of the Ge-S system

    International Nuclear Information System (INIS)

    Cernoskova, E.; Cernosek, Z.; Holubova, J.

    1999-01-01

    In this work the chalcogenide glasses were studied by photoluminescence, electron spin resonance (ESR) as well as optically induce ESR (LESR) methods. Dependence of energy of luminescence and Stokes shift on glass composition was determined

  20. Determining productivity gains from herbaceous vegetation management with 'age-shift' calculations

    Science.gov (United States)

    David B. South; James H. Miller; Mark O. Kimberley; Curtis L. Vanderschaaf

    2006-01-01

    Gains in stand volume that result from competition control and fertilization are sometimes reported as 'percentage gains'. Because percentage gains arithmetically decline over time asstand volume increases, plantation managers have difficultyin using percentage gains to project growth and revenues. The 'age-shift' method quantifies the year...

  1. Free Software Development. 4. Client-Server Implementation of Bone Age Assessment Calculations

    Directory of Open Access Journals (Sweden)

    Sorana Daniela BOLBOACĂ

    2003-03-01

    Full Text Available In pediatrics, bone age also called skeletal maturity, an expression of biological maturity of a child, is an important quantitative measure for the clinical diagnosis of endocrinological problems and growth disorders. The present paper discusses a Java script implementation of Tanner-Whitehouse Method on computer, with complete graphical interface that include pictures and explanations for every bone. The program allows to select a stage (from a set of 7 or 8 stages for every bone (from a set of 20 bones, and also allow user to input some specific data such as natural age, sex, place of residence. Based on TW2 reported values, selected and input data, the program compute the bone age. Java script functions and objects were used in order to make an efficient and adaptive program. Note that in classic way, the program implementation it requires more than 160 groups of instructions only for user interface design. Using of dynamic creation of page, the program became smaller and efficient. The program was tested and put on a web server to serve for directly testing via http service and from where can also be download and runes from a personal computer without internet connection: http://vl.academicdirect.ro/medical_informatics/bone_age/v1.0/

  2. Extraction and development of inset models in support of groundwater age calculations for glacial aquifers

    Science.gov (United States)

    Feinstein, Daniel T.; Kauffman, Leon J.; Haserodt, Megan J.; Clark, Brian R.; Juckem, Paul F.

    2018-06-22

    The U.S. Geological Survey developed a regional model of Lake Michigan Basin (LMB). This report describes the construction of five MODFLOW inset models extracted from the LMB regional model and their application using the particle-tracking code MODPATH to simulate the groundwater age distribution of discharge to wells pumping from glacial deposits. The five study areas of the inset model correspond to 8-digit hydrologic unit code (HUC8) basins. Two of the basins are tributary to Lake Michigan from the east, two are tributary to the lake from the west, and one is just west of the western boundary of the Lake Michigan topographic basin. The inset models inherited many of the inputs to the parent LMB model, including the hydrostratigraphy and layering scheme, the hydraulic conductivity assigned to bedrock layers, recharge distribution, and water use in the form of pumping rates from glacial and bedrock wells. The construction of the inset models entailed modifying some inputs, most notably the grid spacing (reduced from cells 5,000 feet on a side in the parent LMB model to 500 feet on a side in the inset models). The refined grid spacing allowed for more precise location of pumped wells and more detailed simulation of groundwater/surface-water interactions. The glacial hydraulic conductivity values, the top bedrock surface elevation, and the surface-water network input to the inset models also were modified. The inset models are solved using the MODFLOW–NWT code, which allows for more robust handling of conditions in unconfined aquifers than previous versions of MODFLOW. Comparison of the MODFLOW inset models reveals that they incorporate a range of hydrogeologic conditions relative to the glacial part of the flow system, demonstrated by visualization and analysis of model inputs and outputs and reflected in the range of ages generated by MODPATH for existing and hypothetical glacial wells. Certain inputs and outputs are judged to be candidate predictors that, if

  3. Non-linear effects in the radiolysis-optically detected ESR of radical-ion pairs in liquid and glassy solutions. Reactions and motion of organic radicals as studied by ESR and OD ESR spectroscopy

    International Nuclear Information System (INIS)

    Antzutkin, O.

    1992-01-01

    This thesis is divided into two sections. The first part covers an introduction to the Optically Detected Electron Spin Resonance (OD ESR) spectroscopy and a short description of the OD ESR spectrometer built in Linkoeping University in 1991. In the second section the following topics are discussed: Non-linear effects in OD ESR spectroscopy and Reactions and motion of organic radicals trapped in freon matrices. (19 refs.)

  4. New ESR/U-series data for the early Middle Pleistocene site of Isernia la Pineta, Italy

    International Nuclear Information System (INIS)

    Shao Qingfeng; Bahain, Jean-Jacques; Falgueres, Christophe; Peretto, Carlo; Arzarello, Marta; Minelli, Antonella; Thun Hohenstein, Ursula; Dolo, Jean-Michel; Garcia, Tristan; Frank, Norbert; Douville, Eric

    2011-01-01

    Located in Southern Italy, the Early Palaeolithic site of Isernia la Pineta has provided numerous palaeontological remains and artefacts in well-defined fluvio-lacustrine sequence. The normal magnetization of the main archaeological layer t3a and 39 Ar/ 40 Ar date of 610 ± 10 (2σ) ka, obtained from the immediately overlaying geological level, put the Isernia assemblage in the first part of the Middle Pleistocene. Previous ESR/U-series analyses of Isernia fossil teeth have displayed both recent U-uptake and severe underestimation of the ESR/U-series dates in comparison with the 39 Ar/ 40 Ar age. In order to identify the cause of this age underestimation, new analyses were realized in the present study on four bovid teeth directly recovered from the archaeological surface t3a. The ESR/U-series dates obtained were once again strongly underestimated, with an error weighted mean age of 435 ± 24 (1σ) ka. These too young dates could be associated to a change of the environmental γ-dose rate during the geological history of the Isernia site, related to the revealed recent U-uptake into the palaeontological remains of the archaeological level. If we consider that this dose rate change was coeval with a wet interglacial period and taking the 39 Ar/ 40 Ar age as geochronological reference, simulations with two dose rate steps indicate that this change could be correlated with marine isotopic stage 7 (MIS 7).

  5. New ESR/U-series data for the early Middle Pleistocene site of Isernia la Pineta, Italy

    Energy Technology Data Exchange (ETDEWEB)

    Shao Qingfeng, E-mail: shao@mnhn.fr [Departement de Prehistoire du Museum National d' Histoire Naturelle, UMR 7194 CNRS, 1 rue Rene Panhard, F-75013 Paris (France); Bahain, Jean-Jacques; Falgueres, Christophe [Departement de Prehistoire du Museum National d' Histoire Naturelle, UMR 7194 CNRS, 1 rue Rene Panhard, F-75013 Paris (France); Peretto, Carlo; Arzarello, Marta; Minelli, Antonella; Thun Hohenstein, Ursula [Dipartimento di Biologia ed Evoluzione, Universita di Ferrara, C.so Ercole I d' Este 32, I-44121 Ferrara (Italy); Dolo, Jean-Michel; Garcia, Tristan [CEA, LIST, Laboratoire National Henri Becquerel, F-91191 Gif-sur-Yvette cedex (France); Frank, Norbert; Douville, Eric [Laboratoire des Sciences du Climat et de l' Environnement, LSCE/IPSL, UMR 8212 CNRS-CEA-UVSQ, Domaine du CNRS, F-91198 Gif/Yvette cedex (France)

    2011-09-15

    Located in Southern Italy, the Early Palaeolithic site of Isernia la Pineta has provided numerous palaeontological remains and artefacts in well-defined fluvio-lacustrine sequence. The normal magnetization of the main archaeological layer t3a and {sup 39}Ar/{sup 40}Ar date of 610 {+-} 10 (2{sigma}) ka, obtained from the immediately overlaying geological level, put the Isernia assemblage in the first part of the Middle Pleistocene. Previous ESR/U-series analyses of Isernia fossil teeth have displayed both recent U-uptake and severe underestimation of the ESR/U-series dates in comparison with the {sup 39}Ar/{sup 40}Ar age. In order to identify the cause of this age underestimation, new analyses were realized in the present study on four bovid teeth directly recovered from the archaeological surface t3a. The ESR/U-series dates obtained were once again strongly underestimated, with an error weighted mean age of 435 {+-} 24 (1{sigma}) ka. These too young dates could be associated to a change of the environmental {gamma}-dose rate during the geological history of the Isernia site, related to the revealed recent U-uptake into the palaeontological remains of the archaeological level. If we consider that this dose rate change was coeval with a wet interglacial period and taking the {sup 39}Ar/{sup 40}Ar age as geochronological reference, simulations with two dose rate steps indicate that this change could be correlated with marine isotopic stage 7 (MIS 7).

  6. Computation of ESR spectra from the time evolution of the magnetization : Comparison of autocorrelation and Wiener-Khinchin-relation-based methods

    NARCIS (Netherlands)

    Ikeuchi, Hiroki; De Raedt, Hans; Bertaina, Sylvain; Miyashita, Seiji

    2015-01-01

    The calculation of finite temperature electron spin resonance (ESR) spectra for concrete specified crystal configurations is a very important issue in the study of quantum spin systems. Although direct evaluation of the Kubo formula by means of numerical diagonalization yields exact results, memory

  7. Investigation of free radicals in paprika with the ESR method

    International Nuclear Information System (INIS)

    Kispeter, J.; Szabo, I.; Horvath, L.J.

    1998-01-01

    Complete text of publication follows. The ESR method is the one of the most successfully applied method among the physical methods for the identification of radiation or ionising treatment of foods. The identification of free radicals having short and long lifetimes is the base of the measurement. The quantitative determination makes possible the determination of the absorbed dose deriving from 60 Co radiation treatment. It has to be noted that the treatment of the foods with ionising radiation and other treatments (milling, frying, baking) and the oxidative process result free radicals in paprika samples as a function of absorbed radiation dose (2.5; 5 and 10 kGy) on the different particle size and on storage time. The intensities of the samples given after each of the seven stages of the paprika milling increased till the fifth stage corresponding to the effect of a 2 kGy absorbed dose. After conditioning and increasing the water content by 5-8% the ESR intensity shows significant lowering. This value characterises the ESR intensity of not irradiated sample. As an effect of the irradiation the ESR intensities increased along with the increase of the absorbed dose. The samples having lower particle size are more sensible for the identification of the irradiation. Evaluating the art of the decline we concluded that there are free radicals having short and long shelf lifetimes in paprika samples at the same time

  8. Absolute rate measurement by light modulation - ESR technique

    Energy Technology Data Exchange (ETDEWEB)

    Choo, K Y; Gaspar, P P

    1977-01-01

    A rate constant is deduced for the reaction of tert-butoxy radicals and trimethylsilane from the measurement of the phase shift between the modulated light source and the ESR signal of trimethylsilyl radical. The rate constant was found to be 3 x 10/sup -2/M/sup -1/. sec/sup -1/ at -50/sup 0/C.

  9. ESR spectroscopy - an analytical tool for the glass industry

    International Nuclear Information System (INIS)

    Elvers, A.; Weissmann, R.

    2001-01-01

    In the past, wet chemical methods have been developed for the quantitative analysis of polyvalent elements in glasses. The major disadvantage of these chemical methods is that all structural information is lost during analysis. In addition, the analysis of species by wet chemical methods is unreliable due to possible redox reactions during the decomposition process. Therefore, the emphasis is on the physical methods which can directly detect species in bulk glasses. Especially optical and ESR spectroscopy are suitable methods due to their wide range of applications and sensitivity. Concerning quantitative measurements, no comparison between ESR results and chemical analysis of species has been published so far. This work discusses the possible application of ESR spectroscopy in the glass industry by focussing on routine interpretation, the correlation to chemical procedures and quantitative analysis. Results are presented and discussed for iron and chromium in packaging glasses. For example an excellent correlation was found between the Fe 3+ ESR signal and the chemically determined Fe 3+ concentration in glass. (orig.)

  10. Electron beam dose measurements with alanine/ESR dosimeter

    International Nuclear Information System (INIS)

    Rodrigues, O. Jr.; Galante, O.L.; Campos, L.L.

    2001-01-01

    When the aminoacid alanine, CH 3 -CH(NH 2 )-COOH, is exposed to radiation field, stable free radicals are produced. The predominant paramagnetic specie found at room temperature is the CH 3 -CH-COOH. Electron Spin Resonance - ESR is a technique used for quantification and analysis of radicals in solid and liquid samples. The evaluation of the amount of produced radicals can be associated with the absorbed dose . The alanine/ESR is an established dosimetry method employed for high doses evaluation, it presents good performance for X-rays, gamma, electrons, and protons radiation detection. The High Doses Dosimetry Laboratory of Ipen developed a dosimetric system based on alanina/ESR that presents good characteristics for use in gamma fields such as: wide dose range from 10 to 10 5 Gy, low fading, low uncertainty (<5%), no dose rate dependence and non-destructive ESR single readout. The detector is encapsulated in a special polyethylene tube that reduces the humidity problems and improves the mechanical resistance. The IPEN dosimeter was investigated for application in electron beam fields dosimetry

  11. Combined ESR/U-series chronology of Acheulian hominid-bearing layers at Trinchera Galeria site, Atapuerca, Spain

    International Nuclear Information System (INIS)

    Falgueres, Christophe; Bahain, Jean-Jacques; Shao, Qingfeng; Bischoff, James L.; Perez-Gonzalez, Alfredo; Ortega, Ana Isabel; Bermudez de Castro, Jose Maria; Olle, Andreu; Vallverdu, Josep; Quiles, Anita; Ghaleb, Bassam; Moreno, Davinia; Dolo, Jean-Michel; Vallverdu, Josep; Carbonell, Eudald; Arsuaga, Juan Luis

    2013-01-01

    The Sierra de Atapuerca, northern Spain, is known from many prehistoric and paleontologic sites documenting human prehistory in Europe. Three major sites, Gran Dolina, Galeria and Sima del Elefante, range in age from the oldest hominin of Western Europe dated to 1.1 to 1.3 Ma (millions of years ago) at Sima del Elefante to c.a. 0.2 Ma on the top of the Galeria archaeological sequence. Recently, a chronology based on luminescence methods (Thermoluminescence [TL] and Infrared Stimulated Luminescence [IRSL]) applied to cave sediments was published for the Gran Dolina and Galeria sites. The authors proposed for Galeria an age of 450 ka (thousands of years ago) for the units lower GIII and GII, suggesting that the human occupation there is younger than the hominid remains of Sima de los Huesos (≥530 ka) around 1 km away. In this paper, we present new results obtained by combined Electron Spin Resonance/Uranium-series (ESR/U-series) dating on 20 herbivorous teeth from different levels at the Galeria site. They are in agreement with the TL results for the upper part of the stratigraphic sequence (GIV and GIIIb), in the range of between 200 and 250 ka. But for the GIIIa to GIIb levels, the TL ages become abruptly older by 200 ka while ESR ages remain relatively constant. Finally, the TL and ESR data agree in the lowest part of the section (GIIa); both fall in the range of around 350-450 ka. Our results suggest a different interpretation for the GII, GIII and GIV units of Galeria and the upper part of Gran Dolina (TD10 and TD11) than obtained by TL. The ESR/U-series results are supported by a Bayesian analysis, which allows a better integration between stratigraphic information and radiometric data. (authors)

  12. Repeat polymorphisms in ESR2 and AR and colorectal cancer risk and prognosis: results from a German population-based case-control study.

    Science.gov (United States)

    Rudolph, Anja; Shi, Hong; Försti, Asta; Hoffmeister, Michael; Sainz, Juan; Jansen, Lina; Hemminki, Kari; Brenner, Hermann; Chang-Claude, Jenny

    2014-11-07

    Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ESR2) and the androgen receptor gene (AR) with colorectal cancer risk and prognosis. The ESR2 CA and AR CAG repeat polymorphisms were genotyped in 1798 cases (746 female, 1052 male) and 1810 controls (732 female, 1078 male), matched for sex, age and county of residence. Colorectal cancer risk associations overall and specific for gender were evaluated using multivariate logistic regression models adjusted for sex, county of residence and age. Associations with overall and disease-specific survival were evaluated using Cox proportional hazard models adjusted for established prognostic factors (diagnosis of other cancer after colorectal cancer diagnosis, detection by screening, treatment with adjuvant chemotherapy, tumour extent, nodal status, distant metastasis, body mass index, age at diagnosis and year of diagnosis) and stratified for grade of differentiation. Heterogeneity in gender specific associations was assessed by comparing models with and without a multiplicative interaction term by means of a likelihood ratio test. The average number of ESR2 CA repeats was associated with a small 5% increase in colorectal cancer risk (OR = 1.05, 95% CI 1.01-1.10) without significant heterogeneity according to gender or tumoural ESR2 expression. We found no indication for an association between the AR CAG repeat polymorphisms and risk of colorectal cancer. The ESR2 CA and AR CAG repeat polymorphisms were not associated with overall survival or disease specific survival after colorectal cancer diagnosis. Higher numbers of ESR2 CA repeats are potentially associated with a small increase in colorectal cancer risk. Our study does not support an association between colorectal cancer prognosis and the investigated repeat polymorphisms.

  13. Elaboration And Study Of Transfer Alanine/ESR Dosemeters

    International Nuclear Information System (INIS)

    Torres G, Luz A.

    1996-01-01

    The dosimetry is the dose measure imparted by the energy from the ionizing radiation to the matter. The dosemeters is the means used for the determination of such a dose. Diverse dosimetric classes exist, this classification depends in essence of the energy involved in the irradiation process and of its application necessity. It is as well as in radiological protection movie dosemeter is used, and TLD, in the calibration of units, as those of cobalt, the ionization cameras are used, in the detection of superficial contamination the accountants Geiger Muller and proportional etc. The transfer dosimeter Alanine/ESR is used, object of the present work, is characterized because after reading the registered dose, the information is conserved and it can be transferred and read in any team of ESR. Likewise the following dose that is imparted will be added to the previous one registered, this indicates that the dosemeters is of integral character. In the spectra taken ESR, it is determined that the integral double or area under the curve of the spectrum ESR is proportional to the concentration of free radicals generated by the radiation ionization and in turn this concentration is proportional to the dose received by the pills; in last, these proportionality relationships take to that the area under the curve of the spectrum main ESR is proportional to the radiation dose received by the alanine dosemeters. This dosemeter seeks to be an economic alternative that it will lend the calibration service that today offers the ionization Cameras or the acrylic red industrial dosemeters

  14. ESR investigation of alkali metal complexes of galvinoxyl-labeled benzo-15-crown-5 in frozen solution

    International Nuclear Information System (INIS)

    Mukai, Kazuo; Iida, Nobuhito; Ishizu, Kazuhiko

    1982-01-01

    A stable galvinoxyl derivative (1) of benzo-15-crown-5 was prepared and the complex formation between the spin labeled crown ether 1 and the alkali metal and ammonium salts was studied by the ESR technique. Existence of the (2:1) complex of 1 with potassium, rubidium, and ammonium salts was confirmed by the observation of the triplet ESR spectra in ethanol rigid matrix at 77K. Essentially the same g- and D-tensor values are observed for all the (2:1) complexes, indicating similar conformation of the ligand mole cule 1. The zero-field splitting parameters (D and E) are calculated on the basis of the spin distribution of 1 and the assumed molecular structures for the (2:1) complex. By comparing the observed D and E parameters with the calculated ones, the structure of the (2:1) complex in ethanol rigid matrix is discussed. On the other hand, the sodium complexes of 1 show a slightly asymmetric single line, suggesting the (1:1) complex formation btween 1 and the sodium salts. No anions (SCN - , Br - , and I - ) have any appreciable effect on the ESR spectra of both the (2:1) and (1:1) complexes. (author)

  15. Multi-frequency ESR studies on a Haldane magnet in a field-induced phase at ultra-low temperatures

    International Nuclear Information System (INIS)

    Hagiwara, Masayuki; Kashiwagi, Takanari; Idutsu, Yuichi; Honda, Zentaro; Miyazaki, Hiroshi; Harada, Isao

    2010-01-01

    We report the results of multi-frequency electron spin resonance (ESR) measurements on single crystals of Ni(C 5 H 14 N 2 ) 2 N 3 (PF 6 ) which is regarded as the one-dimensional Heisenberg antiferromagnet with spin one, namely the Haldane magnet, at very low temperatures down to about 100 mK. We observed the lowest resonance branch below about 500 mK for the field along the chain direction (H||c), which was observed previously only in an inelastic neutron scattering experiment at 30 mK. We compare the resonance branch with that calculated by a phenomenological field theory, and discuss the field dependence and the temperature sensitivity of this ESR branch.

  16. Calculation models for prediction of Liquefied Natural Gas (LNG) ageing during ship transportation

    Energy Technology Data Exchange (ETDEWEB)

    Miana, Mario; Hoyo, Rafael del; Rodrigalvarez, Vega; Valdes, Jose Ramon [Instituto Tecnologico de Aragon, Area de Investigacion, Desarrollo y Servicios Tecnologicos, Maria de Luna 7, 50018 Zaragoza (Spain); Llorens, Raul [ENAGAS SA, Direccion de Ingenieria y Tecnologia del Gas, Autovia A - 2, km. 306.4, 50012 Zaragoza (Spain)

    2010-05-15

    A group of European gas transportation companies within the European Gas Research Group launched in 2007 the 'MOLAS' Project to provide a software program for the analysis of the Liquefied Natural Gas (LNG) ageing process during ship transportation. This program contains two different modeling approaches: a physical algorithm and an 'intelligent' model. Both models are fed with the same input data, which is composed of the ship characteristics (BOR and capacity), voyage duration, LNG composition, temperature, pressure, and volume occupied by liquid phase at the port of origin, together with pressure at the port of destination. The results obtained are the LNG composition, temperature and liquid volume at the port of destination. Furthermore, the physical model obtains the evolution over time of such variables en route as it is based on unsteady mass balances over the system, while the i-model applies neural networks to obtain regression coefficients from historical data composed only of origin and destination measurements. This paper describes both models and validates them from previous published models and experimental data measured in ENAGAS LNG regasification plants. (author)

  17. Electron spin resonance (ESR) studies on irradiated cocoa beans and niger seeds

    International Nuclear Information System (INIS)

    Mangaonkar, S.R.; Natarajan, V.; Sastry, M.D.; Desai, S.R.P.; Kulkarni, P.R.

    1997-01-01

    Electron spin resonance (ESR) spectra of irradiated (10kGy) and unirradiated cocoa beans and niger seeds have been compared. Unirradiated cocoa beans failed to give any ESR signal, whereas after irradiation (10kGy) an ESR signal at g = 2.0042 was observed. However, ESR signals are given by both irradiated and unirradiated niger seeds. The intensity of signal was found to be dose-dependent up to 10kGy for both seeds. The signals were stable up to 180 days in both cases. The results indicate the possibility of using ESR for distinguishing between irradiated and unirradiated cocoa beans but not for niger seeds

  18. Use of signal subtraction methods in ESR dating of burned flint

    International Nuclear Information System (INIS)

    Porat, Naomi; Schwarcz, H.P.

    1991-01-01

    Geological samples of chert display some of the characteristics of electron spin resonance (ESR) signals of quartz. When chert is heated in a fireplace, most of these signals are annealed. The signals grow again in fire-heated chert buried in archaeological sites, as a result of internal and external radiation doses. The date of the heating event can be determined from the acquired dose (AD) and the dose rate. The E' and Al signals are best suited for dating. Although many cherts, when heated to a sufficient temperature, acquire a carbon radical (C) signal that largely obscures the E' signal, it can be subtracted from digitized spectra. The E' signal also appears to saturate at relatively low doses, restricting the time range of dating to between 200 and 600 ka, depending on the dose rates. The Al signal shows no saturation, but is also interfered with by organic signals, present in burnt and unburned flint. These can also be subtracted to reveal the ''pure'' Al signal. Applying the E' signal to date flint from Yabroud, we obtain an age between 100 and 125 ka, while both thermoluminescence (TL) dating of the flint and ESR dating of tooth enamel give 195 and 225 ka, respectively; the discrepancy may be due to an overestimate of the α-efficiency. At Nahr Ibrahim, the age (c. 80 ka) is consistent with archaeological estimates. (author)

  19. ESR-dosimetry in thermal and epithermal neutron fields for application in boron neutron capture therapy

    Energy Technology Data Exchange (ETDEWEB)

    Schmitz, Tobias

    2016-01-22

    Dosimetry is essential for every form of radiotherapy. In Boron Neutron Capture Therapy (BNCT) mixed neutron and gamma fields have to be considered. Dose is deposited in different neutron interactions with elements in the penetrated tissue and by gamma particles, which are always part of a neutron field. The therapeutic dose in BNCT is deposited by densely ionising particles, originating from the fragmentation of the isotope boron-10 after capture of a thermal neutron. Despite being investigated for decades, dosimetry in neutron beams or fields for BNCT remains complex, due to the variety in type and energy of the secondary particles. Today usually ionisation chambers combined with metal foils are used. The applied techniques require extensive effort and are time consuming, while the resulting uncertainties remain high. Consequently, the investigation of more effective techniques or alternative dosimeters is an important field of research. In this work the possibilities of ESR-dosimeters in those fields have been investigated. Certain materials, such as alanine, generate stable radicals upon irradiation. Using Electron Spin Resonance (ESR) spectrometry the amount of radicals, which is proportional to absorbed dose, can be quantified. Different ESR detector materials have been irradiated in the thermal neutron field of the research reactor TRIGA research reactor in Mainz, Germany, with five setups, generating different secondary particle spectra. Further irradiations have been conducted in two epithermal neutron beams. The detector response, however, strongly depends on the dose depositing particle type and energy. It is hence necessary to accompany measurements by computational modelling and simulation. In this work the Monte Carlo code FLUKA was used to calculate absorbed doses and dose components. The relative effectiveness (RE), linking absorbed dose and detector response, has been calculated using amorphous track models. For the simulation, detailed models of

  20. The effects of body posture, anatomy, age and pregnancy on the calculation of induced current densities at 50 Hz

    International Nuclear Information System (INIS)

    Dimbylow, P.; Findlay, R.

    2010-01-01

    This paper presents calculations of the induced current density in the body at 50 Hz from applied electric and magnetic fields. An extensive ensemble of 25 voxel models has been used to investigate the effects of body posture, anatomy, age and pregnancy. This set includes six adult models, eight child models and seven pregnant female models at various stages of gestation. The four postures investigated in the HPA adult model, NORMAN, were the standard position with the arms at the side, with the arms vertically above the head, the arms horizontally to the side and sitting. (authors)

  1. Electronic structure of radiation damage centre in zinc silicate from ESR hyperfine data

    International Nuclear Information System (INIS)

    Prasad, C.; Chakravarty, Sulata

    1979-01-01

    The occurrence of an ESR spectrum with six hyperfine components in X-irradiated zinc silicate, Zn 2 SiO was reported earlier. It is known that by the use of the experimental ESR data it is possible to work out the electronic structure of the paramagnetic damage center. The values of the hyperfine parameters A and B have been utilized to calculate the values of f'sub(s) and fsub(sigma), the fractional occupation of the 3s and 3psub(sigma) orbitals of the metal atom by the unpaired electron. The metal atom is 27 Al (I = 5/2, n.a. = 100%) which is present as an impurity in the lattice and occupies silicon sites. The bonding between the metal atom and each of the surrounding oxygen atom is assumed to be of the sigma-type. The values obtained for the fractional occupation are : f'sub(s) = 0.71 x 10sup(-2), fsub(sigma) = 14.65 x10sup(-2). The unpaired electron appears to belong to the ligand atom and is moderately delocalised on the Al atom where it occupies mainly the 3psup(sigma) orbital and not the 3s orbital. (auth.)

  2. ESR accident dosimetry using medicine tablets coated with sugar

    International Nuclear Information System (INIS)

    Kai, A.; Miki, T.; Ikeya, M.

    1990-01-01

    Properties of radiation-induced radicals in medicine tablets were investigated using electron spin resonance (ESR). A sharp ESR signal sensitive to gamma ray irradiation was observed in the sugar coating part of the tablets. The signal has anisotropic g values of g 1 = 2.0009, g 2 = 2.0007 and g 3 = 2.0002. The signal grows linearly with dose at least up to about 20 Gy. No fading was observed at room temperature even when exposed to sunlight. The dose to artificially irradiated tablets was estimated using the signal intensity and a previously determined calibration curve. The signal in sugar coated tablets can be utilised for dose measurements. In particular, the wide distribution of sugar coated tablets allows the use of the tablets as accident dosemeters. (author)

  3. Lyoluminescence and ESR correlation studies of trehalose dihydrate

    Energy Technology Data Exchange (ETDEWEB)

    Raman, Anand E-mail: anandr@apsara.barc.ernet.in; Oommen, Issac K.; Gundu Rao, T.K.; Sharma, D.N

    2002-07-01

    ESR studies of irradiated lyoluminescence (LL) phosphor, trehalose dihydrate showed a linear free radical growth up to a dose of 11 kGy. The LL output measured under oxygen equilibrated conditions showed an extension of the dosimetric response from 0.6 to 6 kGy. ESR spectral analysis indicates the formation of two radical species viz., 'a' and 'b' and their involvement in the LL process. The estimated free radical concentrations of radicals 'a' and 'b' were found to be 6.81x10{sup 15} and 1.35x10{sup 16} g{sup -1}, respectively, for a gamma dose of 10.8 kGy.

  4. ESR studies of the radiation effects on polystyrene

    International Nuclear Information System (INIS)

    Garrett, R.W.; O'Donnell, J.H.; Pomery, P.J.

    1976-01-01

    The aim of this work was to investigate the polystyrene system (both pure and commercial samples) to elucidate the type and percentage of each paramagnetic species upon exposure to various irradiation doses. The size of dose plays a vital role in the type of spectra obtained. Upon irradiation in vacuo, polystyrene displays ESR spectra which are basically triplet in character but the line spacing and intensities of components are observed to depend on the magnitude of the irradiation dose. G value for the total radicals present and for the individual species present as a function of dose have been obtained. The relative concentration of each paramagnetic species has been determined through computer simulation of the observed ESR spectra. The relative stability of the different species with respect to temperature is discussed. The results for deuterated polystyrene is used to support those obtained for the unsubstituted polystyrene system. (author)

  5. Experimental Progress in Fast Cooling in the ESR

    CERN Document Server

    Steck, Markus; Beller, Peter; Franzke, Bernhard; Nolden, Fritz

    2005-01-01

    The ESR storage ring at GSI is operated with highly charged heavy ions. Due to the high electric charge the ions interact much stronger with electromagnetic fields. Therefore both cooling methods which are applied to stored ions in the ESR, stochastic cooling and electron cooling, are more powerful than for singly charged particles. The experimental results exhibit cooling times for stochastic cooling of a few seconds. For cold ion beams, electron cooling provides cooling times which are one to two orders of magnitude smaller. The beams are cooled to beam parameters which are limited by intrabeam scattering. At small ion numbers, however, intrabeam scattering is suppressed by electron cooling, clear evidence was found that the ion beam forms a one-dimensional ordered structure, a linear chain of ions. The strengths of stochastic cooling and electron cooling are complementary and can be combined favorably. Stochastic cooling is employed for pre-cooling of hot secondary beams followed by electron cooling to pro...

  6. ESR signal changes recorded in γ-irradiated bovine livers

    International Nuclear Information System (INIS)

    Kikuchi, Masahiro; Kobayashi, Yasuhiko

    2015-01-01

    After fresh raw livers of bovine were exposed to γ-rays on ice, radiation-induced radicals in the livers were measured in liquid nitrogen using electron spin resonance spectroscopy. In the magnetic field of 320.5 to 335.5 mT, the signals responsible to absorbed doses were found. The signal intensity from a main peak was increased up to 5 kGy. The side peaks existing both low and high magnetic field of the main peak showed linear responses as increasing absorbed doses. Radiation-induced radicals were found in a tissue without bones from animals. Without complicated sample preparations, the raw bovine livers can be easily measured on ESR at liquid nitrogen temperature. The ESR method may be applicable to distinguish irradiated fresh raw livers within a few days after irradiation. (author)

  7. The Uncertainty estimation of Alanine/ESR dosimetry

    International Nuclear Information System (INIS)

    Kim, Bo Rum; An, Jin Hee; Choi, Hoon; Kim, Young Ki

    2008-01-01

    Machinery, tools and cable etc are in the nuclear power plant which environment is very severe. By measuring actual dose, it needs for extending life expectancy of the machinery and tools and the cable. Therefore, we estimated on dose (gamma ray) of Wolsong nuclear power division 1 by dose estimation technology for three years. The dose estimation technology was secured by ESR(Electron Spin Resonance) dose estimation using regression analysis. We estimate uncertainty for secure a reliability of results. The uncertainty estimation will be able to judge the reliability of measurement results. The estimation of uncertainty referred the international unified guide in order; GUM(Guide to the Expression of Uncertainty in Measurement). It was published by International Standardization for Organization (ISO) in 1993. In this study the uncertainty of e-scan and EMX those are ESR equipment were evaluated and compared. Base on these results, it will improve the reliability of measurement

  8. Estimation of background radiation doses for the Peninsular Malaysia's population by ESR dosimetry of tooth enamel.

    Science.gov (United States)

    Rodzi, Mohd; Zhumadilov, Kassym; Ohtaki, Megu; Ivannikov, Alexander; Bhattacharjee, Deborshi; Fukumura, Akifumi; Hoshi, Masaharu

    2011-08-01

    Background radiation dose is used in dosimetry for estimating occupational doses of radiation workers or determining radiation dose of an individual following accidental exposure. In the present study, the absorbed dose and the background radiation level are determined using the electron spin resonance (ESR) method on tooth samples. The effect of using different tooth surfaces and teeth exposed with single medical X-rays on the absorbed dose are also evaluated. A total of 48 molars of position 6-8 were collected from 13 district hospitals in Peninsular Malaysia. Thirty-six teeth had not been exposed to any excessive radiation, and 12 teeth had been directly exposed to a single X-ray dose during medical treatment prior to extraction. There was no significant effect of tooth surfaces and exposure with single X-rays on the measured absorbed dose of an individual. The mean measured absorbed dose of the population is 34 ± 6.2 mGy, with an average tooth enamel age of 39 years. From the slope of a regression line, the estimated annual background dose for Peninsular Malaysia is 0.6 ± 0.3 mGy y(-1). This value is slightly lower than the yearly background dose for Malaysia, and the radiation background dose is established by ESR tooth measurements on samples from India and Russia.

  9. The nuclear physics program at SIS/ESR

    International Nuclear Information System (INIS)

    Henning, W.

    1991-01-01

    The present workshop discusses the physics program to be addressed with the new photon spectrometer TAPS. Part of this program will be carried out at the new accelerator facility SIS/ESR at GSI Darmstadt. To put the TAPS activities at SIS into perspective, an overview is given in the following discussing the new GSI facility, the research program under consideration and the various experimental facilities besides TAPS to carry out these studies. (orig.)

  10. Rapid screening for anthocyanins in cane sugars using ESR spectroscopy.

    Science.gov (United States)

    Thamaphat, Kheamrutai; Goodman, Bernard A; Limsuwan, Pichet; Smith, Siwaporn Meejoo

    2015-03-15

    Anthocyanin, which is soluble in water and released into sugar steam during extraction, was investigated in this study. The anthocyanin content in refined sugar, plantation white sugar, soft brown sugar and raw sugar was determined using electron spin resonance (ESR) spectroscopy, which was operated at room temperature, and compared with spectra from standard anthocyanin. The ESR spectra of red and violet anthocyanins was predominantly g ≈ 2.0055, which corresponded to an unpaired electron located in the pyrylium ring. Signals for Fe(III) and Mn(II), which naturally occur in plants, were found in raw sugar, soft brown sugar and standard anthocyanin but were absent from refined sugar and plantation white sugar due to the refining process. In addition, the ESR results were correlated with the apparent colour of the sugar, which was determined using the method of the International Commission for Uniform Methods of Sugar Analysis and inductively coupled plasma optical emission spectroscopy. Copyright © 2014 Elsevier Ltd. All rights reserved.

  11. Electron Spin Resonance (ESR) studies of returned comet nucleus samples

    International Nuclear Information System (INIS)

    Tsay, Fundow; Kim, S.S.; Liang, R.H.

    1989-01-01

    The most important objective of the Comet Nucleus Sample Returm Mission is to return samples which could reflect formation conditions and evolutionary processes in the early solar nebula. It is expected that the returned samples will consist of fine-grained silicate materials mixed with ices composed of simple molecules such as H 2 O, NH 3 , CH 4 as well as organics and/or more complex compounds. Because of the exposure to ionizing radiation from cosmic-ray, gamma-ray, and solar wind protons at low temperature, free radicals are expected to be formed and trapped in the solid ice matrices. The kind of trapped radical species together with their concentration and thermal stability can be used as a dosimeter as well as a geothermometer to determine thermal and radiation histories as well as outgassing and other possible alternation effects since the nucleus material was formed. Since free radicals that are known to contain unpaired electrons are all paramagnetic in nature, they can be readily detected and characterized in their native form by the Electron Spin Resonance (ESR) method. In fact, ESR has been shown to be a non-destructive, highly sensitive tool for the detection and characterization of paramagnetic, ferromagnetic, and radiation damage centers in terrestrial and extraterrestrial geological samples. The potential use of ESR as an effective method in the study of returned comet nucleus samples, in particular, in the analysis of fine-grained solid state icy samples is discussed

  12. Estimation of dose in irradiated chicken bone by ESR method

    International Nuclear Information System (INIS)

    Tanabe, Hiroko; Hougetu, Daisuke

    1998-01-01

    The author studied the conditions needed to routinely estimate the radiation dose in chicken bone by repeated re-irradiation and measuring ESR signals. Chicken meat containing bone was γ-irradiated at doses of up to 3kGy, accepted as the commercially used dose. The results show that points in sample preparation and ESR measurement are as follows: Both ends of bone are cut off and central part of compact bone is used for experiment. To obtain accurate ESR spectrum, marrow should be scraped out completely. Sample bone fragments of 1-2mm particle size and ca.100mg are recommended to obtain stable and maximum signal. In practice, by re-irradiating up to 5kGy and extrapolating data of the signal intensity to zero using linear regression analysis, radiation dose is estimated. For example, in one experiment, estimated doses of chicken bones initially irradiated at 3.0kGy, 1.0kGy, 0.50kGy and 0.25kGy were 3.4kGy, 1.3kGy, 0.81kGy and 0.57kGy. (author)

  13. Aging

    International Nuclear Information System (INIS)

    Finch, S.C.; Beebe, G.W.

    1975-01-01

    The hypothesis that ionizing radiation accelerates natural aging has been under investigation at the Atomic Bomb Casualty Commission since 1959. Postmortem observations of morphologic and chemical changes, tests of functional capacity, physical tests and measurements, clinical laboratory tests, tissue changes, morbidity, and mortality have all been examined by ABCC investigators interested in this hypothesis. These studies have been beset with conceptual difficulties centered on the definition and measurement of aging. An empirical approach early led to the calculation of an index of physiologic age as a linear combination of age-related tests of various organ systems. Most studies have been negative but have not involved the large numbers that might be required to provide strong evidence for or against the hypothesis. Mortality, however, has been examined on the basis of a large sample and over the period 1950-1972 had provided no support for the hypothesis of radiation-accelerated aging. Ionizing radiation dose, of course shorten human life, but its life-shortening effect appears to be the result of specific radiation-induced disease, especially neoplasms. The hypothesis is now much less attractive than it was 10-20 years ago but still has some value in stimulating research on aging. The experience of the A-bomb survivors provides an unusual opportunity for a definitive test of the hypothesis. (auth.)

  14. Evolution of ESR Technology and Equipment for Long Hollow Ingots Manufacture

    Science.gov (United States)

    Medovar, Lev; Stovpchenko, Ganna; Dudka, Grigory; Kozminskiy, Alexander; Fedorovskii, Borys; Lebid, Vitalii; Gusiev, Iaroslav

    In this paper development of both ESR technology and equipment for hollow ingot manufacture review and analysis are presented. The real complications of hollow ingot manufacture and some tendentious issues which restrict process dissemination are discussed. An actual data of modern manufacture of as-cast pipes for heat and power engineering by traditional ESR with consumable electrode are given. Results of microstructure and nonmetal inclusion investigations have shown the high quality of as-cast ESR pipes. On the basis of these results the possibility to produce huge ESR hollows (up 5000 mm in dia) with final goal drastically to reduce setting ratio on forged shells and rings or even replace it by ESR hollows as-cast is grounded. Two new ESR technologies — consumable electrodes change and liquid metal usage — have passed pilot tests for heavy hollow production and shown very prospective results to be presented.

  15. Preliminary study on the detection of irradiated food containing bone by ESR spectroscopy

    International Nuclear Information System (INIS)

    Zhao Yongfu; Ha Yiming; Liu Ting; Wang Rongfu; Wang Changbao

    2007-01-01

    Electron spin resonance (ESR) spectroscopy is one of the most effective technique for detection of irradiated food containing bone. It was found that the radiation -induced ESR signal (Spectrum, g factor and peak-to-peak line width AH) in bone before and after irradiation was significantly different and could be easily distinguished from the endogenous ESR signal. Sample preparation studies showed vacuum drying and grinding at frozen temperature was an ideal method. A linear relationship was observed between ESR signal intensity and the absorbed dose (0.3-10.1kGy). It can be proposed that 0.5kGy absorbed doses can be detected by ESR for irradiated food containing bone though detecting sensitivity is very different at the same irradiated dosage with different food such as pork, beef, duck, chicken and fish. The ultimate purpose of this work is to establish a national criterion for detection of irradiated foodstuffs by use of ESR. (authors)

  16. Electron spin resonance (ESR) spectroscopy applied to radiation dosimetry and other fields

    International Nuclear Information System (INIS)

    Schneider, C.C.J.

    1994-12-01

    A short introduction to the theory and practice of ESR spectroscopy is given. ESR alanine dosimetry for low and high LET (linear energy transfer) ionising radiation is described, indicating its advantages over traditional methods. Problems arising in the therapy dose range (below 5 Gy), and possible future developments, are mentioned. The application of ESR to the radiation processing of materials and foodstuffs, to geological dating, biology, molecular chemistry and to medicine is discussed. Some examples of chemical analyses are also presented. (orig.)

  17. Development of an ESR/MR dual-imaging system as a tool to detect bioradicals

    International Nuclear Information System (INIS)

    Fujii, Hirotada; Aoki, Masaaki; Haishi, Tomoyuki; Itoh, Kouichi; Sakata, Motomichi

    2006-01-01

    A system combining electron spin resonance imaging (ESRI) with another imaging modality capable of enabling visualization of the distribution of bioradicals on an anatomical map of the specimens would be a superior biomedical imaging system. We describe the development of an electron spin resonance ESR/MR dual-imaging system with one permanent magnet and the biomedical applications of this system. The magnetic circuit developed for the ESR/MR dual-imaging system consisted of the permanent magnet made of Fe-Nd-B, pole pieces, and poke. The permanent magnet was installed on the MR side only, and the ESR side was made of pole pieces only. The magnetic field was adjusted to 0.5T at MR and to 0.042T at ESR. The overall dimensions of the magnet developed for the ESR/MR imaging system were 460 (W) x 440 (D) x 460 (H) mm, and it weighed 220 kg. The distance of each center for the magnet for ESR and MR imaging could be set as close as 200 mm. The entire ESR/MR imaging system can be installed in a common laboratory without magnetic shielding. MR images of plants (myoga) and small animals (mice and rats) were successfully acquired with or without ESR operation. ESR spectra of nitroxyl spin probes were also measured, even with MRI operation. ESR signals of triarylmethyl derivatives with narrow line-width (0.026 mT) were observed in living mice while MRI was operating. The ESR/MR imaging dual functions work properly with no electric or magnetic interference. The ESR/MR dual images demonstrate that this system enables visualization of the distribution of bioradicals on the anatomical map of the object. (author)

  18. A study for association and interaction analysis to metabolic syndrome and the ESR1 gene on cardiovascular autonomic neuropathy in a Chinese Han population.

    Science.gov (United States)

    Zeng, Fangfang; Zhou, Linuo; Tang, Zihui

    2016-01-01

    The aim of this study was to investigate the association and interaction of metabolic syndrome (MetS) and estrogen receptor alpha 1 (ESR1) gene polymorphisms on cardiovascular autonomic neuropathy (CAN). A large-scale, population-based study was conducted to analyze the interaction of MetS and ESR1 gene polymorphisms to CAN, including a total of 1977 Chinese subjects. The most common studied single nucleotide polymorphism of ESR1 gene-rs9340799, was genotyped. Multiple logistic regression (MLR) was performed to evaluate the interaction effect of environmental variables and gene polymorphisms. Interaction on an additive scale can be calculated by using the relative excess risk due to interaction (RERI), the proportion attributable to interaction (AP), and the synergy index (S). After controlling potential confounders, MLR showed that significant association between MetS and CAN (p interaction was estimated by using RETI = 0.396 (95 % CI 0.262 to 0.598), AP = 0.216 (95 % CI -0.784 to 1.216) and S = 1.906 (95 % CI 0.905 to 4.015). The present findings suggest that MetS is significantly associated with CAN and provide evidence for the hypothesis that MetS and ESR1 gene polymorphism (rs9340799) have interactive effects on CAN. ClinicalTrials gov Identifier NCT02461342.

  19. From dating to biophysics -- 20 years of progress in applied ESR spectroscopy

    International Nuclear Information System (INIS)

    Regulla, Dieter

    2000-01-01

    ESR spectroscopy represents a tool for quantitative radiation analysis that was developed somehow simultaneously for dating purposes in Japan and in Germany for high-level standardization, in the mid-seventies. Meanwhile, ESR dosimetry has reached an established metrology level. Present research fields of ESR dosimetry consider post-accident dose reconstruction in the environment, and biophysical dosimetry using human tissues. The latter promises a re-definition of radiation risk for chronicle exposure to be derived from individuals of the early nuclear facilities in Russia, and hopefully United States in the future. An attempt is made to sketch development and potential future of the ESR technique

  20. Influences of different sample preparation methods on tooth enamel ESR signals

    International Nuclear Information System (INIS)

    Zhang Wenyi; Jiao Ling; Zhang Liang'an; Pan Zhihong; Zeng Hongyu

    2005-01-01

    Objective: To study the influences of different sample preparation methods on tooth enamel ESR signals in order to reduce the effect of dentine on their sensitivities to radiation. Methods: The enamel was separated from dentine of non-irradiated adult teeth by mechanical, chemical, or both methods. The samples of different preparations were scanned by an ESR spectrometer before and after irradiation. Results: The response of ESR signals of samples prepared with different methods to radiation dose was significantly different. Conclusion: The selection of sample preparation method is very important for dose reconstruction by tooth enamel ESR dosimetry, especially in the low dose range. (authors)

  1. Detection of gamma-irradiated peanuts by ESR spectroscopy and GC analysis of hydrocarbons

    Energy Technology Data Exchange (ETDEWEB)

    Wei Mingli; An Li [Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing (China); Yi Mingha, E-mail: wangyilwm@163.co [Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing (China); Feng Wang [Institute of Agro-food Science and Technology, Chinese Academy of Agricultural Sciences, 100193 Beijing (China); Yan Lizhang [Division of Metrology in Ionizing Radiation and Medicine, National Institute of Metrology, 100013 Beijing (China)

    2011-03-15

    Peanuts were analyzed by electron spin resonance (ESR) spectroscopy and gas chromatography (GC) before and after gamma irradiation. Using European protocols, the validity and effectiveness of these two techniques were compared with regard to sample preparation, sample and solvent consumption and dose-response curves after irradiation. The results showed the possibility of using ESR and GC for distinguishing between irradiated and unirradiated peanuts. A radiation dose of 0.1 kGy could be detected by ESR but not by GC. The results also indicated that GC is an effective method for qualitative analysis of irradiated peanut, while ESR is suitable for the rapid detection of irradiated peanuts.

  2. ESR Spectroscopy for the Study of Oxidative Processes in Food and Beverages

    DEFF Research Database (Denmark)

    Andersen, Mogens Larsen; Skibsted, Leif Horsfelt

    2018-01-01

    Radicals are intermediates in many reactions that deteriorate foods. The detection of radicals by electron spin resonance, ESR, can provide mechanistic and uantitative information about these reactions, which has led to ESR-based methods for early prediction of shelf life of foods and beverages....... ESR is also used for monitoring irradiated foods, since the generated radicals are often quite stable. ESR can moreover give important information about oxidation mechanisms and microscopic physical structural aspects, which is useful for developing protective measures against oxidation in food....

  3. Association with litter size of new polymorphisms on ESR1 and ESR2 genes in a Chinese-European pig line

    Directory of Open Access Journals (Sweden)

    Rodriguez Carmen

    2007-02-01

    Full Text Available Abstract The objective of this study was to search for polymorphisms in the coding region of the estrogen receptors 1 and 2 (ESR1 and ESR2 and to analyze the effects of these variants and the well known intronic ESR1 Pvu II polymorphism on litter size in a Chinese-European pig line. We identified five silent single nucleotide polymorphisms (SNP in the ESR1 cDNA: c.669T > C (exon 3, c.1227C > T (exon 5, c.1452C > T (exon 7, c.1665T > C and c.1755A > G (exon 8. One pair of these SNP (c.1665T > C and c.1755A > G co-segregated in the analyzed line, and the SNP c.669T > C showed the same segregation pattern as the Pvu II polymorphism. These polymorphisms were tested in this study, although the c.1452C > T SNP within exon 7 was not analyzed due to its low informativeness. In the ESR2 cDNA, one missense SNP was found within exon 5, which caused an amino acid substitution in the coded protein: "c.949G > A (p.Val317Met" and was tested on sow litter size. Information on 1622 litter records from 408 genotyped sows was analyzed to determine whether these SNP influenced the total number of piglets born (TNB or the number of born alive (NBA. The polymorphisms ESR1: [Pvu II; c.669T > C], ESR1: [c.1665T > C; c.1755A > G] and ESR2: c.949G > A showed no statistically significant association with litter size. However, the ESR1: c.1227T allele was significantly associated with TNB. The additive substitution effect was estimated to be 0.40 piglets born per litter (P

  4. ESR/tooth enamel dosimetry application to Chernobyl case: individual retrospective dosimetry of the liquidators and wild animals

    International Nuclear Information System (INIS)

    Bugai, A.; Baryakchtar, V.G.; Baran, N.

    1996-01-01

    ESR/tooth enamel dosimetry technique was used for individual retrospective dosimetry of the servicemen who had worked in 1986-1987 at the liquidation of consequences of the Chernobyl accident. For 18 investigated cases, the values varied from 0,10 (sensitivity limit) to 1,75 Gy. The same technique was used for individual dosimetry of wild animals boars, red deers, elks) hunted at contaminated 30-km area around the Chernobyl Power Plant. Measured values varied from 0,20 to 5,0 Gy/year and were compared with calculated for external and internal irradiation

  5. Age-specific effects of estrogen receptors' polymorphisms on the bone traits in healthy fertile women: the BONTURNO study

    Directory of Open Access Journals (Sweden)

    Pirazzoli Antonella

    2009-04-01

    Full Text Available Abstract Background Skeletal characteristics such as height (Ht, bone mineral density (BMD or bone turnover markers are strongly inherited. Common variants in the genes encoding for estrogen receptor alpha (ESR1 and beta (ESR2 are proposed as candidates for influencing bone phenotypes at the population level. Methods We studied 641 healthy premenopausal women aged 20–50 years (yrs participating into the BONTURNO study. Exclusion criteria were irregular cyclic menses, low trauma fracture, metabolic bone or chronic diseases. Serum C-telopeptide of type I collagen (CTX, osteocalcin (OC, and N-terminal propeptide of type I procollagen (P1NP were measured in all enrolled subjects, who underwent to lumbar spine (LS, total hip (TH and femoral neck (FN BMD evaluation by DXA. Five hundred seventy Caucasian women were genotyped for ESR1 rs2234693 and rs9340799 and ESR2 rs4986938 polymorphisms. Results Although no genotype differences were found in body parameters, subjects with combined ESR1 CCGG plus ESR2 AA-AG genotype were taller than those with opposite genotype (P = 0.044. Moreover, ESR1 rs2234693 genotypes correlated with family history of osteoporosis (FHO and hip fracture (FHF (P When clustered by age, 20–30 yrs old subjects, having at least one ESR1 rs2234693 C allele presented lower LS- (P = 0.008 and TH-BMD (P = 0.047 than TT genotypes. In 41–50 yrs age, lower FN-BMD was associated with ESR2 AA (P = 0.0180 subjects than in those with the opposite genotype. ESR1 rs2234693 and rs9340799 and ESR2 rs4986938 polymorphisms did not correlate with age-adjusted values of OC, CTX and P1NP. Conclusion These findings support the presence of age-specific effects of ESR1 and ESR2 polymorphisms on various skeletal traits in healthy fertile women.

  6. ESR dating of elephant teeth and radiation dose rate estimation in soil

    International Nuclear Information System (INIS)

    Taisoo Chong; Ohta, Hiroyuki; Nakashima, Yoshiyuki; Iida, Takao; Saisho, Hideo

    1989-01-01

    Chemical analysis of 238 U, 232 Th and 40 K in the dentine as well as enamel of elephant tooth fossil has been carried out in order to estimate the internal absorbed dose rate of the specimens, which was estimated to be (39±4) mrad/y on the assumption of early uptake model of radionuclides. The external radiation dose rate in the soil including the contribution from cosmic rays was also estimated to be (175±18) mrad/y with the help of γ-ray spectroscopic techniques of the soil samples in which the specimens were buried. The 60 Co γ-ray equivalent accumulated dose of (2±0.2) x 10 4 rad for the tooth enamel gave ''ESR age'' of (9±2) x 10 4 y, which falls in the geologically estimated range between 3 x 10 4 and 30 x 10 4 y before the present. (author)

  7. Physics book: CRYRING'a'ESR

    International Nuclear Information System (INIS)

    Lestinsky, M.; Aurand, B.; Bagnoud, V.; Andrianov, V.

    2016-01-01

    CRYRING is a heavy ion storage ring, formerly located in Stockholm University. During close to two decades of operation in Sweden, many significant scientific contributions to atomic and molecular physics were achieved using CRYRING. To further leverage its capabilities into the realm of intense beams of highly charged ions, of exotic isotopes, and antiprotons, it has for long been proposed to relocate CRYRING from Sweden to GSI/FAIR, which is the CRYRING'a'ESR project. In Darmstadt, the ring is being modernized and adapted to the GSI/FAIR standards and set up downstream of ESR. In the different chapters we sketch out a broad scientific program in the fields of atomic and nuclear physics and at their intersection. The realization will allow for exciting high-precision spectroscopy studies of atomic systems and their dynamics where special emphasis is given to the effects of quantum electrodynamics (QED) and electron-correlation in the strong field domain (Chap. 2). The intersection of atomic and nuclear physics is addressed where the imprint of nuclear effects on the electronic shell are investigated with spectroscopic methods (Chap. 3), and exploring the nuclear structure, nuclear dynamical processes and quantitative measurements of astrophysically relevant (p, γ)-reaction rates (Chap. 4). These experiments are of prime interest for testing modern theoretical methods on fundamental processes as well as for applications in astrophysics and for modelling plasmas. In the domain of slow collisions in of heavy ions at highest charge-states where atomic processes are prevailed by large perturbations, these studies are expected to refine substantially our understanding of the physics of extreme electromagnetic fields. Also, CRYRINGaESR will offer extracted high-quality ion beams, thus enabling novel research opportunities for external-target experiments with slow highly-charged ions. The experimental boundary conditions and suggested future instrumentation

  8. Investigation of the isochronous mode of the experimental storage ring (ESR) and the collector ring (CR). Decay spectroscopy of highly charged stored 140Pr ions at the FRS-ESR facility

    International Nuclear Information System (INIS)

    Litvinov, Sergey A.

    2008-11-01

    The combination of the present fragment separator FRS and the cooler-storage ring ESR at GSI provides conditions for accurate mass and unique half-life measurements of exotic nuclei. A major part of this doctoral work has been devoted to investigations of the isochronous ion-optical operating mode of the present ESR facility and the planned Collector Ring (CR) facility at FAIR. A detailed ion-optical study of the isochronous storage ring with the emphasis on the main parameters has been done. For example, a simple scaling law providing a quantitative estimate for the mass resolving power as a function of the transverse acceptance has been derived. The ion-optical matching of the FRS-ESR has been calculated and experimentally verified for both the standard and the isochronous operating modes of the ESR. In addition, the dispersion function of a stored ion beam has been measured for both ion-optical modes at the straight section. The improved setting for higher transmission in the standard mode has been used in an experiment on the half-life measurements of highly-charged ions. Orbital electron capture (EC) and/or β + -decay rates of 140 Pr ions with zero-, one- and two- bound electrons have been measured. A complementary future study of EC-decay in highly-charged 64 Cu ions is discussed. Based on the present experience, the ion-optical matching between the future in-flight fragment separator Super-FRS and the CR has been calculated. The isochronous mode of the CR has been calculated. A dedicated Monte-Carlo code (ISOCHRON) has been developed in order to investigate the influence of the transverse acceptance, the closed orbit distortions, the fringe fields of the quadrupoles, the magnetic field imperfections of the magnets on the mass resolving power. The influence of chromaticity on the isochronicity has been investigated. The correction of the chromaticity and of second-order isochronicity has been performed employing sextupole magnets in the arcs of the CR. The

  9. Investigation of the isochronous mode of the experimental storage ring (ESR) and the collector ring (CR). Decay spectroscopy of highly charged stored {sup 140}Pr ions at the FRS-ESR facility

    Energy Technology Data Exchange (ETDEWEB)

    Litvinov, Sergey A.

    2008-11-15

    The combination of the present fragment separator FRS and the cooler-storage ring ESR at GSI provides conditions for accurate mass and unique half-life measurements of exotic nuclei. A major part of this doctoral work has been devoted to investigations of the isochronous ion-optical operating mode of the present ESR facility and the planned Collector Ring (CR) facility at FAIR. A detailed ion-optical study of the isochronous storage ring with the emphasis on the main parameters has been done. For example, a simple scaling law providing a quantitative estimate for the mass resolving power as a function of the transverse acceptance has been derived. The ion-optical matching of the FRS-ESR has been calculated and experimentally verified for both the standard and the isochronous operating modes of the ESR. In addition, the dispersion function of a stored ion beam has been measured for both ion-optical modes at the straight section. The improved setting for higher transmission in the standard mode has been used in an experiment on the half-life measurements of highly-charged ions. Orbital electron capture (EC) and/or {beta}{sup +}-decay rates of {sup 140}Pr ions with zero-, one- and two- bound electrons have been measured. A complementary future study of EC-decay in highly-charged {sup 64}Cu ions is discussed. Based on the present experience, the ion-optical matching between the future in-flight fragment separator Super-FRS and the CR has been calculated. The isochronous mode of the CR has been calculated. A dedicated Monte-Carlo code (ISOCHRON) has been developed in order to investigate the influence of the transverse acceptance, the closed orbit distortions, the fringe fields of the quadrupoles, the magnetic field imperfections of the magnets on the mass resolving power. The influence of chromaticity on the isochronicity has been investigated. The correction of the chromaticity and of second-order isochronicity has been performed employing sextupole magnets in the

  10. ACCEPTABILITY EVALUATION FOR USING ICRP TISSUE WEIGHTING FACTORS TO CALCULATE EFFECTIVE DOSE VALUE FOR SEPARATE GENDER-AGE GROUPS OF RUSSIAN FEDERATION

    Directory of Open Access Journals (Sweden)

    L. V. Repin

    2013-01-01

    Full Text Available An article describes radiation risk factors for several gender-age population groups according to Russian statistical and medical-demographic data, evaluates the lethality rate for separate nosologic forms of malignant neoplasms based on Russian cancer registries according to the method of the International Agency for Cancer Research. Relative damage factors are calculated for the gender-age groups under consideration. The tissue weighting factors recommended by ICRP to calculate effective doses are compared with relative damage factors calculated by ICRP for the nominal population and with similar factors calculated in this work for separate population cohorts in theRussian Federation. The significance of differences and the feasibility of using tissue weighting factors adapted for the Russian population in assessing population risks in cohorts of different gender-age compositions have been assessed.

  11. ESR study on free radicals trapped in crosslinked polytetrafluoroethylene (PTFE)

    International Nuclear Information System (INIS)

    Oshima, Akihiro; Tabata, Yoneho; Seguchi, Tadao

    1997-01-01

    Free radicals in crosslinked PTFE which formed by 60 Co γ-rays irradiation at 77 K and at room temperature were studied by electron spin resonance (ESR) spectroscopy. The crosslinked PTFE specimens with different crosslinking density were prepared by electron beam irradiation in the molten state. The ESR spectra observed in the irradiated crosslinked PTFE are much different from those in non-crosslinked PTFE (virgin); a broad singlet component increases with increasing the crosslinking density, G-value of radicals is much higher in crosslinked PTFE than in non-crosslinked one. Free radicals related to the broad component are trapped in the non-crystalline region of crosslinked PTFE and rather stable at room temperature, whereas radicals trapped in amorphous non-crosslinked PTFE are unstable at room temperature. It is thought that most of free radicals trapped in the crosslinked PTFE are formed in the crosslinked amorphous region. The trapped radicals decays around 383 K (110 o C) due to the molecular motion of α-relaxation. (Author)

  12. Study of free-radical centers in lignin with 2-mm band ESR spectroscopy

    International Nuclear Information System (INIS)

    Kuzina, S.I.; Demidov, S.V.; Brezgunov, A.Yu.; Poluehktov, O.G.; Grinberg, O.Ya.; Dubinskij, A.A.; Mikhajlov, A.I.; Lebedev, Ya.S.

    1993-01-01

    The nature of paramagnetic centers in pristine lignin and lignin, treated with molecular chlorine, aqueous solutions of acids and alkalis, and γ- and UV-irradiated, was studied with 2-mm band ESR spectroscopy. Most of the observed singlet ESR lines are accounted for by radicals with conjugated bonds. High reactivity of double bonds of polyconjugated systems was in the processes studied

  13. The Impact of ESR1 Mutations on the Treatment of Metastatic Breast Cancer.

    Science.gov (United States)

    Pejerrey, Sasha M; Dustin, Derek; Kim, Jin-Ah; Gu, Guowei; Rechoum, Yassine; Fuqua, Suzanne A W

    2018-05-07

    After nearly 20 years of research, it is now established that mutations within the estrogen receptor (ER) gene, ESR1, frequently occur in metastatic breast cancer and influence response to hormone therapy. Though early studies presented differing results, sensitive sequencing techniques now show that ESR1 mutations occur at a frequency between 20 and 40% depending on the assay method. Recent studies have focused on several "hot spot mutations," a cluster of mutations found in the hormone-binding domain of the ESR1 gene. Throughout the course of treatment, tumor evolution can occur, and ESR1 mutations emerge and become enriched in the metastatic setting. Sensitive techniques to continually monitor mutant burden in vivo are needed to effectively treat patients with mutant ESR1. The full impact of these mutations on tumor response to different therapies remains to be determined. However, recent studies indicate that mutant-bearing tumors may be less responsive to specific hormonal therapies, and suggest that aromatase inhibitor (AI) therapy may select for the emergence of ESR1 mutations. Additionally, different mutations may respond discretely to targeted therapies. The need for more preclinical mechanistic studies on ESR1 mutations and the development of better agents to target these mutations are urgently needed. In the future, sequential monitoring of ESR1 mutational status will likely direct personalized therapeutic regimens appropriate to each tumor's unique mutational landscape.

  14. ESR study of weakly irradiated organic conductors: TMTSF-DMTCNQ and (TMTSF)2PF6

    International Nuclear Information System (INIS)

    Forro, L.; Beuneu, F.

    1982-01-01

    ESR experiments are presented on irradiated TMTSF-DMTCNQ and (TMTSF) 2 PF 6 . They suggest that a weak disorder extends the metallic phases to low temperatures. Surprisingly, disorder has no effect on the ESR linewidth of (TMTSF) 2 PF 6 between 20 and 30 K, where the d.c. conductivity changes a lot with disorder. (author)

  15. Use of thermodynamic calculation to predict the effect of Si on the ageing behavior of Al-Mg-Si-Cu alloys

    International Nuclear Information System (INIS)

    Ji, Yanli; Zhong, Hao; Hu, Ping; Guo, Fuan

    2011-01-01

    Research highlights: → Thermodynamic calculation can predict the ageing behavior of 6xxx alloys. → The hardness level of the alloys depends on the Si content in as-quenched matrix. → The precipitation strengthening effect depends on the Mg 2 Si level of the alloys. -- Abstract: Thermodynamic calculation was employed to predict the influence of Si content on the ageing behavior of Al-Mg-Si-Cu alloys. In addition, experiments were carried out to verify the predictions. The results show that thermodynamic calculation can predict the effect of Si content on the ageing behavior of the studied alloys. This study further proposes that the hardness level of alloys during ageing is directly related to the Si content in the as-quenched supersaturated solution, while the precipitation strengthening effect is directly related to the Mg 2 Si level of the alloys.

  16. Effect of estrogen receptor-alpha (ESR1 gene polymorphism on high density lipoprotein levels in response to hormone replacement therapy

    Directory of Open Access Journals (Sweden)

    N.C. Nogueira-de-Souza

    2009-12-01

    Full Text Available Studies have shown that estrogen replacement therapy and estrogen plus progestin replacement therapy alter serum levels of total, LDL and HDL cholesterol levels. However, HDL cholesterol levels in women vary considerably in response to hormone replacement therapy (HRT. A significant portion of the variability of these levels has been attributed to genetic factors. Therefore, we investigated the influence of estrogen receptor-alpha (ESR1 gene polymorphisms on HDL levels in response to postmenopausal HRT. We performed a prospective cohort study on 54 postmenopausal women who had not used HRT before the study and had no significant general medical illness. HRT consisted of conjugated equine estrogen and medroxyprogesterone acetate continuously for 1 year. The lipoprotein levels were measured from blood samples taken before the start of therapy and after 1 year of HRT. ESR1 polymorphism (MspI C>T, HaeIII C>T, PvuII C>T, and XbaI A>G frequencies were assayed by restriction fragment length polymorphism. A general linear model was used to describe the relationships between HDL levels and genotypes after adjusting for age. A significant increase in HDL levels was observed after HRT (P = 0.029. Women with the ESR1 PvuII TT genotype showed a statistically significant increase in HDL levels after HRT (P = 0.032. No association was found between other ESR1 polymorphisms and HDL levels. According to our results, the ESR1 PvuII TT genotype was associated with increased levels of HDL after 1 year of HRT.

  17. Quantitative detection of absorbed dose of irradiated dried fruit by ESR spectroscopy method

    International Nuclear Information System (INIS)

    Li Weiming; Ha Yiming; Zhao Yongfu; Zhang Yanli

    2011-01-01

    Sunflower seeds, walnuts, pistachios, and hazelnuts were used as experimental materials which were irradiated at 1.0, 3.0, 5.0 and 10.0 kGy, respectively. The relationships and correlations between ESR signal intensity and irradiation dosages were studied. The results showed that ESR spectra of irradiated samples were obviously different from that of CK, and the ESR signal intensity was positively related with the irradiation dose. After irradiation, the ESR intensity and spectrum shapes all changed and all four samples were clearly identified irradiated or unirradiated. The appearances of the two weak satellite lines which situated left and right to the intense singlet line in walnuts and pistachios proved the existence of cellulose radical. The detection dose limit of irradiated walnut was 1 kGy, and the detection limits of the other three samples were lower than 1 kGy. In conclusion, the ESR method could be used to irradiated. (authors)

  18. Relaxation behavior of radicals produced in irradiated black pepper under various moisture conditions by ESR

    International Nuclear Information System (INIS)

    Kameya, Hiromi; Kawauchi, Risa; Shimoyama, Yuhei; Kaeda, Yoko; Ogawa, Satoko; Nakamura, Hideo; Ukai, Mitsuko

    2008-01-01

    Black pepper is easy to be contaminated by microorganism and often processed to γ-irradiation. ESR has been used for the detection of radicals induced in irradiated spices. Using ESR, we revealed the effects of moisture condition during storage of irradiated black pepper on the saturation behavior of ESR signal. The ESR spectrum of black pepper consists of a broad sextet centered at g=2.0, a singlet as same g-value and a singlet at g=4.0. The irradiation causes two new signals, one is the strong and sharp singlet signal at g=2.0 and the other is the side signal. We found that the signal intensity originated by the radicals of black pepper with and without radiation decayed in the high humidity condition during storage. The ESR signal intensity of irradiated black pepper decayed during storage and showed almost the same intensity level as that of non-irradiated black pepper during storage. (author)

  19. ESR analyses on tooth enamel from the Paleolithic layers at the Obi-Rakhmat hominid site, Uzbekistan: Tackling a dating controversy

    International Nuclear Information System (INIS)

    Skinner, Anne R.; Blackwell, Bonnie A.B.; Mian, Abubakar; Baboumian, Shaunte M.; Blickstein, Joel I.B.; Wrinn, Patrick J.; Krivoshapkin, A.I.; Derevianko, A.P.; Lundburg, Joyce A.

    2007-01-01

    In the Tien Shan Mt., northeastern Uzbekistan, the Obi-Rakhmat rockshelter has yielded newly discovered hominid remains associated with an abundant Paleolithic industry and a rich faunal assemblage in typical cave fill sediment. Eight bovid teeth were dated by standard and isochron ESR to resolve the 50 ky discrepancy between the 14 C and 234 Th/ 234 U ages for Obi-Rakhmat. All the dentine contained high U concentrations, up to 150 ppm. External dose rates of 470-820μGy/y were calculated from volumetrically averaged sediment geochemistry for all layers and mineralogies within 30 cm of the teeth. One tooth from Layer 12.3 averaged 57±2ka assuming linear U uptake, while three from Layer 13 averaged 66±2ka, that from Layer 14.3,73±4ka, and three from Layer 21.2,87±4ka. Isochron and 230 Th/ 234 U analyses suggest that the teeth did experience linear uptake with ∼5% recent secondary U remobilization. These dates indicate that the site was inhabitted during Oxygen Isotope Stages (OIS) 5a-4, as climates were generally cooling, but beginning to fluctuate more widely. Assuming a constant sedimentation rate of 22 cm/ky, the hominid remains date to ∼74ka

  20. Depressive-like effect of prenatal exposure to DDT involves global DNA hypomethylation and impairment of GPER1/ESR1 protein levels but not ESR2 and AHR/ARNT signaling.

    Science.gov (United States)

    Kajta, Malgorzata; Wnuk, Agnieszka; Rzemieniec, Joanna; Litwa, Ewa; Lason, Wladyslaw; Zelek-Molik, Agnieszka; Nalepa, Irena; Rogóż, Zofia; Grochowalski, Adam; Wojtowicz, Anna K

    2017-07-01

    Several lines of evidence suggest that exposures to Endocrine Disrupting Chemicals (EDCs) such as pesticides increase the risks of neuropsychiatric disorders. Despite extended residual persistence of dichlorodiphenyltrichloroethane (DDT) in the environment, the mechanisms of perinatal actions of DDT that could account for adult-onset of depression are largely unknown. This study demonstrated the isomer-specific induction of depressive-like behavior and impairment of Htr1a/serotonin signaling in one-month-old mice that were prenatally exposed to DDT. The effects were reversed by the antidepressant citalopram as evidenced in the forced swimming (FST) and tail suspension (TST) tests in the male and female mice. Prenatally administered DDT accumulated in mouse brain as determined with gas chromatography and tandem mass spectrometry, led to global DNA hypomethylation, and altered the levels of methylated DNA in specific genes. The induction of depressive-like behavior and impairment of Htr1a/serotonin signaling were accompanied by p,p'-DDT-specific decrease in the levels of estrogen receptors i.e. ESR1 and/or GPER1 depending on sex. In contrast, o,p'-DDT did not induce depressive-like effects and exhibited quite distinct pattern of biochemical alterations that was related to aryl hydrocarbon receptor (AHR), its nuclear translocator ARNT, and ESR2. Exposure to o,p'-DDT increased AHR expression in male and female brains, and reduced expression levels of ARNT and ESR2 in the female brains. The evolution of p,p'-DDT-induced depressive-like behavior was preceded by attenuation of Htr1a and Gper1/GPER1 expression as observed in the 7-day-old mouse pups. Because p,p'-DDT caused sex- and age-independent attenuation of GPER1, we suggest that impairment of GPER1 signaling plays a key role in the propagation of DDT-induced depressive-like symptoms. Copyright © 2017 Elsevier Ltd. All rights reserved.

  1. ESR imaging investigations of two-phase systems.

    Science.gov (United States)

    Herrmann, Werner; Stösser, Reinhard; Borchert, Hans-Hubert

    2007-06-01

    The possibilities of electron spin resonance (ESR) and electron spin resonance imaging (ESRI) for investigating the properties of the spin probes TEMPO and TEMPOL in two-phase systems have been examined in the systems water/n-octanol, Miglyol/Miglyol, and Precirol/Miglyol. Phases and regions of the phase boundary could be mapped successfully by means of the isotropic hyperfine coupling constants, and, moreover, the quantification of rotational and lateral diffusion of the spin probes was possible. For the quantitative treatment of the micropolarity, a simplified empirical model was established on the basis of the Nernst distribution and the experimentally determined isotropic hyperfine coupling constants. The model does not only describe the summarized micropolarities of coexisting phases, but also the region of the phase boundary, where solvent molecules of different polarities and tendencies to form hydrogen bonds compete to interact with the NO group of the spin probe. Copyright 2007 John Wiley & Sons, Ltd.

  2. Human estrogen receptor (ESR) gene locus: PssI dimorphism

    Energy Technology Data Exchange (ETDEWEB)

    Coleman, R T; Taylor, J E; Frossard, P M [California Biotechnology Inc., Mountain View, CA (USA); Shine, J J [Garvan Institute, Darlinghurst (Australia)

    1988-07-25

    pESR-2, a 2.1 kb partial cDNA containing the entire translated sequence of the human estrogen receptor mRNA isolated from MCF-7 human breast cancer cells, was subcloned in the Eco RI site of pBR322. PssI (PuGGNCCPy) identifies a single two-allele polymorphism with bands at either 1.7 or 1.4 kb, as well as invariant bands at 12.6, 9.3, 4.1, 3.7, 2.4, 2.2, and 1.2 kb. Its frequency was studied in 77 unrelated North American Caucasians. The human estrogen receptor gene has been localized to 6q24 -- q27 by in situ hybridization. Co-dominant segregation is demonstrated in one family (8 individuals).

  3. Broadband lasercooling of relativistic ions at the ESR

    Energy Technology Data Exchange (ETDEWEB)

    Winters, Danyal; Ullmann, Johannes; Clark, Colin; Dimopoulou, Christina; Nolden, Fritz; Steck, Markus [GSI Darmstadt (Germany); Bussmann, Michael; Siebold, Mathias; Seltmann, Michael; Schramm, Ulrich [HZDR Dresden (Germany); Wen, Weiqiang [GSI Darmstadt (Germany); IMP CAS Lanzhou (China); Sanchez, Rodolfo; Lochmann, Matthias [GSI Darmstadt (Germany); Uni Mainz (Germany); Beck, Tobias; Rein, Benjamin; Tichelmann, Sascha; Birkl, Gerhard; Walther, Thomas [TU Darmstadt (Germany); Zhang, Dacheng; Yang, Jie; Ma, Xinwen [IMP CAS Lanzhou (China); Noertershaeuser, Wilfried [GSI Darmstadt (Germany); Uni Mainz (Germany); TU Darmstadt (Germany); Kuehl, Thomas [GSI Darmstadt (Germany); Uni Mainz (Germany); HI Jena (Germany); Stoehlker, Thomas [GSI Darmstadt (Germany); Uni Jena (Germany); HI Jena (Germany)

    2013-07-01

    We present new results on broadband laser cooling of stored relativistic C{sup 3+} ion beams at the ESR in Darmstadt. For the first time we could show laser cooling of bunched relativistic ion beams using a UV-laser which could scan over a very large range and thus cool all the ions in the 'bucket'. This scheme is much more versatile than a previous scheme, where the bunching frequency was scanned relative to a fixed laser frequency. We have also demonstrated that this cooling scheme works without pre-electron cooling, which is a prerequisite for its general application to future storage rings and synchrotrons, such as the HESR and the SIS100 at FAIR. We also present results from in vacuo VUV-fluorescence detectors, which have proven to be very effective.

  4. An ESR study on the detection of irradiated red lentil

    International Nuclear Information System (INIS)

    Ercan, I.; Eken, M.

    2001-01-01

    The purpose of this work is to investigate in detail detection of irradiated red lentil. In this way, red lentil powder was analysed by using Bruker EMX ESR spectrometer before and after irradiation between the doses 1-9 kGy at ambient conditions. It was observed that seeds of non-irradiated and irradiated red lentil have a signal having six lines due to Mn''+''2 content. However hull of the red lentil has a single line whose origin is still unknown. Besides, this signal has superposed with the radiation induced one. It was also found that the intensity of radiation induced signal was decreased logarithmically in time, and the change in the intensity was minimal at low doses

  5. ESR studies of heat denaturation in Cu myoglobin complexes

    International Nuclear Information System (INIS)

    Louro, S.R.W.; Ribeiro, S.C.; Bemski, G.

    1975-01-01

    An investigation is made on the behaviour of Cu2 + and Fe3 + in copper doped myoglobin, subjected to heat treatment. ESR is observed at X-band. The amplitude of the g = 5.9 line of the high spin F 3 + in met-myoglobin is studied as a function of the temperature of the heat treatment, the pH and the length of time of exposure to the heat treatment. These experiments are performed for both the pure protein and for the copper-myoglobin complex, at pH between 5 and 8.5. Results concerning the decrease of the amplitude of Fe 3+ high spin signal are discussed in comparison with Hollocher's results in hemoglobin. The Cu spectra obtained are interpreted, with the aid of a computer program, Kivelson and Neiman's results being used to analyse the authors data

  6. Dating Of Remains Of Neanderthals And Homo Sapiens From Anatolian Region By ESR-US Combined Methods Preliminary Results

    Directory of Open Access Journals (Sweden)

    Samer Farkh

    2015-08-01

    Full Text Available We tried in the present study to apply the electron spin resonance method ESR combined with uranium-series method US for dating fossilized human teeth and found valuable archaeological sites such as Karain Cave in Anatolia. Karain Cave is a crucial site in a region that has yielded remains of Neanderthals and Homo sapiens our direct ancestors. The dating of these remains allowed us to trace the history since the presence of man on earth. Indeed Anatolia in Turkey is an important region of the world because it represents a passage between Africa the Middle East and Europe. Our study was conducted on faunal teeth found near human remains. The combination of ESR and US data on the teeth provides an understanding of their complex geochemical evolution and get better estimated results. Our samples were taken from the central cutting where geological layers are divided into archaeological horizons each 10 cm. The AH4 horizon of I.3 layer which represents the boundary between the Middle Paleolithic and Upper Paleolithic is dated to 29 4 ka by the ESR-US model. Below two horizons AH6 and AH8 in the same layer I.4 are dated respectively 40 6 and 45 7 ka using the ESR-US model. In layer II where a stalagmite floor was taken we made two U-Th dating at the base and on the top ages oscillated around 120 ka. Since human remains were collected from AH3 horizon for Homo sapiens and AH5 and AH7 horizons for the Neanderthal man so the dates obtained in AH4 AH6 and AH8 represent maximum ages. Thus they provide the disappearance of Neanderthal man between 45 and 40 ka and the appearance of Homo sapiens in 29 ka in Anatolia region. Undoubtedly there is a chronological gap between the Middle and Upper Paleolithic represented by the disappearance of Neanderthals and the appearance of sapiens and none of our results confirm the contemporaneity of these two species in this region.

  7. ESR concept paper on value-based radiology.

    Science.gov (United States)

    2017-10-01

    The European Society of Radiology (ESR) established a Working Group on Value-Based Imaging (VBI WG) in August 2016 in response to developments in European healthcare systems in general, and the trend within radiology to move from volume- to value-based practice in particular. The value-based healthcare (VBH) concept defines "value" as health outcomes achieved for patients relative to the costs of achieving them. Within this framework, value measurements start at the beginning of therapy; the whole diagnostic process is disregarded, and is considered only if it is the cause of errors or complications. Making the case for a new, multidisciplinary organisation of healthcare delivery centred on the patient, this paper establishes the diagnosis of disease as a first outcome in the interrelated activities of the healthcare chain. Metrics are proposed for measuring the quality of radiologists' diagnoses and the various ways in which radiologists provide value to patients, other medical specialists and healthcare systems at large. The ESR strongly believes value-based radiology (VBR) is a necessary complement to existing VBH concepts. The Society is determined to establish a holistic VBR programme to help European radiologists deal with changes in the evolution from volume- to value-based evaluation of radiological activities. Main Messages • Value-based healthcare defines value as patient's outcome over costs. • The VBH framework disregards the diagnosis as an outcome. • VBH considers diagnosis only if wrong or a cause of complications. • A correct diagnosis is the first outcome that matters to patients. • Metrics to measure radiologists' impacts on patient outcomes are key. • The value provided by radiology is multifaceted, going beyond exam volumes.

  8. Cantilever-detected high-frequency ESR measurement using a backward travelling wave oscillator

    International Nuclear Information System (INIS)

    Tokuda, Y; Hirano, S; Ohmichi, E; Ohta, H

    2012-01-01

    Our cantilever-detected electron spin resonance (ESR) technique is motivated for terahertz ESR spectroscopy of a tiny single crystal at low temperature. In this technique, ESR signal is detected as deflection of a sample-mounted cantilever, which is sensitively detected by built-in piezoresistors. So far, ESR detection at 315 GHz was succeeded using Gunn oscillator. In this study, we combine our ESR technique with a backward traveling wave oscillator (BWO), which can cover a wide frequency range 120-1200 GHz, to achieve better spectral resolution. Experiments were carried out at 4.2 K for a single crystal of Co Tutton salt with a newly constructed optical system. We successfully observed two ESR absorption lines in BWO frequencies up to 370 GHz. From multi-frequency measurements, the observed ESR lines shifted linearly with BWO frequency, being consistent with paramagnetic resonance. The estimated g values are g 1 = 3.00 and g 2 = 3.21. The spin sensitivity was estimated to ∼10 12 spins/gauss at 370 GHz.

  9. ESR technique for noninvasive way to quantify cyclodextrins effect on cell membranes

    International Nuclear Information System (INIS)

    Grammenos, A.; Mouithys-Mickalad, A.; Guelluy, P.H.; Lismont, M.; Piel, G.; Hoebeke, M.

    2010-01-01

    Research highlights: → ESR: a new tool for cyclodextrins study on living cells. → Cholesterol and phospholipid extraction by Rameb in a dose- and time-dependent way. → Extracted phospholipids and cholesterol form stable aggregates. → ESR spectra show that lipid rafts are damaged by Rameb. → Quantification of the cholesterol extraction on cell membranes in a noninvasive way. -- Abstract: A new way to study the action of cyclodextrin was developed to quantify the damage caused on cell membrane and lipid bilayer. The Electron Spin Resonance (ESR) spectroscopy was used to study the action of Randomly methylated-beta-cyclodextrin (Rameb) on living cells (HCT-116). The relative anisotropy observed in ESR spectrum of nitroxide spin probe (5-DSA and cholestane) is directly related to the rotational mobility of the probe, which can be further correlated with the microviscosity. The use of ESR probes clearly shows a close correlation between cholesterol contained in cells and cellular membrane microviscosity. This study also demonstrates the Rameb ability to extract cholesterol and phospholipids in time- and dose-dependent ways. In addition, ESR spectra enabled to establish that cholesterol is extracted from lipid rafts to form stable aggregates. The present work supports that ESR is an easy, reproducible and noninvasive technique to study the effect of cyclodextrins on cell membranes.

  10. Coupled 230Th/234U-ESR analyses for corals: A new method to assess sealevel change

    International Nuclear Information System (INIS)

    Blackwell, Bonnie A.B.; Teng, Steve J.T.; Lundberg, Joyce A.; Blickstein, Joel I.B.; Skinner, Anne R.

    2007-01-01

    Although coupled 230 Th/ 234 U-ESR analyses have become routine for dating teeth, they have never been used for corals. While the ESR age depends on, and requires assumptions about, the time-averaged cosmic dose rate, D-bar cos (t), 230 Th/ 234 U dates do not. Since D-bar cos (t) received by corals depends on the attenuation by any intervening material, D-bar cos (t) response reflects changing water depths and sediment cover. By coupling the two methods, one can determine the age and a unique D-bar cos,coupled (t) simultaneously. From a coral's water depth and sedimentary history as predicted by a given sealevel curve, one can predict D-bar cos,sealevel (t). If D-bar cos,coupled (t) agrees well with D-bar cos,sealevel (t), this provides independent validation for the curve used to build D-bar cos,sealevel (t). For six corals dated at 7-128 ka from Florida Platform reef crests, the sealevel curve by Waelbroeck et al. [2002. Sea-level and deep water temperature changes derived from benthonic foraminifera isotopic records. Quat. Sci. Rev. 21, 295-305] predicted their D-bar cos,coupled (t) values as well as, or better than, the SPECMAP sealevel curve. Where a whole reef can be sampled over a transect, a precise test for sealevel curves could be developed

  11. Bias correction of nutritional status estimates when reported age is used for calculating WHO indicators in children under five years of age.

    Science.gov (United States)

    Quezada, Amado D; García-Guerra, Armando; Escobar, Leticia

    2016-06-01

    To assess the performance of a simple correction method for nutritional status estimates in children under five years of age when exact age is not available from the data. The proposed method was based on the assumption of symmetry of age distributions within a given month of age and validated in a large population-based survey sample of Mexican preschool children. The main distributional assumption was consistent with the data. All prevalence estimates derived from the correction method showed no statistically significant bias. In contrast, failing to correct attained age resulted in an underestimation of stunting in general and an overestimation of overweight or obesity among the youngest. The proposed method performed remarkably well in terms of bias correction of estimates and could be easily applied in situations in which either birth or interview dates are not available from the data.

  12. Bias correction of nutritional status estimates when reported age is used for calculating WHO indicators in children under five years of age

    Directory of Open Access Journals (Sweden)

    Amado D Quezada

    2016-05-01

    Full Text Available Objective.To assess the performance of a simple correction method for nutritional status estimates in children under five years of age when exact age is not available from the data. Materials and methods. The proposed method was ba- sed on the assumption of symmetry of age distributions within a given month of age and validated in a large population-based survey sample of Mexican preschool children. Results. The main distributional assumption was consistent with the data. All prevalence estimates derived from the correction method showed no statistically significant bias. In contrast, failing to correct attained age resulted in an underestimation of stunting in general and an overestimation of overweight or obesity among the youngest. Conclusions. The proposed method performed remarkably well in terms of bias correction of estimates and could be easily applied in situations in which either birth or interview dates are not available from the data.

  13. 2 mm range ESR of the transmutation-produced phosphorus impurity in 6HSiC

    International Nuclear Information System (INIS)

    Kalabukhova, E.N.; Lukin, S.N.; Mokhov, E.N.

    1993-01-01

    Phosphorus impurity is introduced into 6HSiC monocrystals via neutron transmutation doping. Parameters of ESR two spectra referred to ESR spectra of separated phosphorus atoms in the lattice cubic and hexagonal position are detected and determined in the specimens at T=4.2 K. variation dynamics of ESR spectra of phosphorus and nitrogen within 4.2-73 K temperature range is studied. Ionization energies of phosphorus atoms are determined to be less, than those of nitrogen atoms, and ionization energy of phosphorus atoms in hexagonal position is higher, than that of phosphorus atoms in cubic position

  14. ESR studies of high-energy phosphorus-ion implanted synthetic diamond crystals

    Energy Technology Data Exchange (ETDEWEB)

    Isoya, J [University of Library and Information Science, Tsukuba, Ibaraki (Japan); Kanda, H; Morita, Y; Ohshima, T

    1997-03-01

    Phosphorus is among potential n-type dopants in diamond. High pressure synthetic diamond crystals of type IIa implanted with high energy (9-18 MeV) phosphorus ions have been studied by using electron spin resonance (ESR) technique. The intensity and the linewidth of the ESR signal attributed to the dangling bond of the amorphous phase varied with the implantation dose, suggesting the nature of the amorphization varies with the dose. The ESR signals of point defects have been observed in the low dose as-implanted crystals and in the high dose crystals annealed at high temperature and at high pressure. (author)

  15. μSR spectroscopy on free radicals: a complement to ESR spectroscopy

    International Nuclear Information System (INIS)

    Cox, S.F.J.; Symons, M.C.R.

    1986-12-01

    The paper on ''μSR spectroscopy on free radicals'' was presented to the conference on ''Muon spin, rotation, relaxation and resonance'' Uppsala, 1986. The spectroscopic techniques for both ESR and μSR are described, along with the interpretation of the spectra, hyperfine coupling constants and radical structure. A comparison of ESR and μSR data is carried out with respect: to 1) isotope effects in organic radicals, 2) isotope effects in solids, -the isotropic muonium defect centres, and 3) the muonium defect centres in semiconductors. Radical categories examined using ESR and μSR are discussed, including new species, formation mechanisms, and ionic species. (U.K.)

  16. Self-assessment of eligibility for early medical abortion using m-Health to calculate gestational age in Cape Town, South Africa: a feasibility pilot study.

    Science.gov (United States)

    Momberg, Mariette; Harries, Jane; Constant, Deborah

    2016-04-16

    Although abortion is legally available in South Africa, barriers to access exist. Early medical abortion is available to women with a gestational age up to 63 days and timely access is essential. This study aimed to determine women's acceptability and ability to self-assess eligibility for early medical abortion using an online gestational age calculator. Women's acceptability, views and preferences of using mobile technology for gestational age (GA) determination were explored. No previous studies to ascertain the accuracy of online self-administered calculators in a non-clinical setting have been conducted. A convenience sample of abortion seekers were recruited from two health care clinics in Cape Town, South Africa in 2014. Seventy-eight women were enrolled and tasked with completing an online self-assessment by entering the first day of their last menstrual period (LMP) onto a website which calculated their GA. A short survey explored the feasibility and acceptability of employing m-Health technology in abortion services. Self-calculated GA was compared with ultrasound gestational age obtained from clinical records. Participant mean age was 28 (SD 6.8), 41% (32/78) had completed high school and 73% (57/78) reported owning a smart/feature phone. Internet searches for abortion information prior to clinic visit were undertaken by 19/78 (24%) women. Most participants found the online GA calculator easy to use (91%; 71/78); thought the calculation was accurate (86%; 67/78) and that it would be helpful when considering an abortion (94%; 73/78). Eighty-three percent (65/78) reported regular periods and recalled their LMP (71%; 55/78). On average women overestimated GA by 0.5 days (SD 14.5) and first sought an abortion 10 days (SD 14.3) after pregnancy confirmation. Timely access to information is an essential component of effective abortion services. Advances in the availability of mobile technology represent an opportunity to provide accurate and safe abortion

  17. Radical cations in radiation chemistry of aldehydes. ESR study and quantum chemical analysis

    International Nuclear Information System (INIS)

    Belevskii, V.N.; Tyurin, D.A.; Chuvilkin, N.D.

    1998-01-01

    Quantum-chemical (MNDO-UHF) calculations of electronic, spin and energy characteristics of radical cations (RC) of ethanal, propanal, butanal, and pentanal and their distonic isomers were performed. The calculations both with 'frozen' (vertical ionization) and completely optimize geometry (adiabatic approximation) were made. It was been shown that the most positive charge and spin population are localized at O atoms and adjacent C atom as well as at aldehyde protons. The C-H bonds corresponding to those protons as well as neighboring C-O and C-C bonds are considerable weaker (longer) in radical cations as compared to their neutral precursors. That is why such reaction centers are apt to deprotonation with the formation of acyl radical as well as to α- and β-splitting (scission) which are well-known from aldehydes mass-spectra. Our calculations shown that distonic RC (products of intramolecular H-atom transfer) are more stable as compare to their classical isomers: e.g. the difference in energy ΔE = -0.95 eV, -1.2 eV, and -1.5 eV for tree distonic isomers of butanal RC as compare to classical isomer, ΔE -1.2 eV for distonic RC of ethanal. The results of calculations are effectively correlated with ESR data obtained in freonic solutions, X- and gamma-irradiated at 77 K and in liquid aldehydes, X-irradiated by using 2,4,6-tri-tert-burylnitrosobenzene (BNB) and t-BuNO (NtB) as a spin traps. (author)

  18. ESR study on the interaction between carbon blacks and oxygen molecules; ESR ho ni yoru carbon black to sanso bunshi tono sogo sayo no kenkyu

    Energy Technology Data Exchange (ETDEWEB)

    Okazaki, M.; Toriyama, K.; Konishi, Y. [National Industrial Research Institute of Nagoya, Nagoya (Japan)

    2000-02-24

    Interaction between carbon blacks and oxygen molecules has been studied by means of electron spin resonance (ESR) spectroscopy. The ESR spectra of the carbon blacks appears at the g-value of free spin, which are contributed by both isolated electrons and conduction electrons. Upon introducing oxygen to the system the ESR linewidth was broadened in proportion to the partial pressure of oxygen. In case of lampblack (LB 101, Degussa) the interaction was not so strong that it took a tong time at 77K for the linewidth to reach the maxmum value. In case of gassblack (P 140 V, Degussa), on the other hand, the oxygen was easily adsorbed at 298K and the linewidth at 77K became its maximum immediately after cooling. The number of unpaired electrons decreased when the system was kept at 298 K and the decrease was prominent for the local spins. These phenomena have been explained with a simple band model for the electron. (author)

  19. Identification of irradiated sage tea (Salvia officinalis L.) by ESR spectroscopy

    International Nuclear Information System (INIS)

    Tepe Cam, Semra; Engin, Birol

    2010-01-01

    The use of electron spin resonance (ESR) spectroscopy to accurately distinguish irradiated from unirradiated sage tea was examined. Before irradiation, sage tea samples exhibit one asymmetric singlet ESR signal centered at g=2.0037. Besides this central signal, two weak satellite signals situated about 3 mT left and right to it in radiation-induced spectra. Irradiation with increasing doses caused a significant increase in radiation-induced ESR signal intensity at g=2.0265 (the left satellite signal) and this increase was found to be explained by a polynomial varying function. The stability of that radiation-induced ESR signal at room temperature was studied over a storage period of 9 months. Also, the kinetic of signal at g=2.0265 was studied in detail over a temperature range 313-353 K by annealing samples at different temperatures for various times.

  20. DETECTION OF SOME IRRADIATED NUTS BY ELECTRON SPIN RESONANCE (ESR) TECHNIQUE

    International Nuclear Information System (INIS)

    KHALLAF, M.F.; YASIN, N.M.N.; EL-NASHABY, F.M.; ALI, H.G.M.; EL-SHIEMY, S.M.

    2008-01-01

    The present investigation was carried out to establish the electron spin resonance (ESR) detection method for identifying irradiated nuts (almond and pistachio). Samples were irradiated with 2, 4 and 6 kGy and stored at room temperature (25± 2 0 C) for six months to study the possibility of detecting its previous irradiation treatments by ESR spectroscopy. Analysis was carried out just after irradiation treatment and during ambient storage period. The ESR signal intensities of irradiated samples were markedly increased correspondingly with irradiation dose as a result of free radicals generated by gamma irradiation so, all irradiated samples under investigation could be differentiated from non-irradiated ones immediately after irradiation treatment. The decay in radicals responsible of ESR signals showed the identification of irradiated almond (shell or edible part) and pistachio (edible part) was impossible after six months of ambient storage

  1. DETECTION OF SOME IRRADIATED NUTS BY ELECTRON SPIN RESONANCE (ESR) TECHNIQUE

    Energy Technology Data Exchange (ETDEWEB)

    KHALLAF, M F; YASIN, N M.N. [Food Science Dept., Faculty of Agriculture, Ain Shams University, Cairo (Egypt); EL-NASHABY, F M; ALI, H G.M.; EL-SHIEMY, S M [Nuclear Research Centre, Atomic Energy Authority, Cairo (Egypt)

    2008-07-01

    The present investigation was carried out to establish the electron spin resonance (ESR) detection method for identifying irradiated nuts (almond and pistachio). Samples were irradiated with 2, 4 and 6 kGy and stored at room temperature (25{+-} 2{sup 0}C) for six months to study the possibility of detecting its previous irradiation treatments by ESR spectroscopy. Analysis was carried out just after irradiation treatment and during ambient storage period. The ESR signal intensities of irradiated samples were markedly increased correspondingly with irradiation dose as a result of free radicals generated by gamma irradiation so, all irradiated samples under investigation could be differentiated from non-irradiated ones immediately after irradiation treatment. The decay in radicals responsible of ESR signals showed the identification of irradiated almond (shell or edible part) and pistachio (edible part) was impossible after six months of ambient storage.

  2. Production of High Quality Die Steels from Large ESR Slab Ingots

    Science.gov (United States)

    Geng, Xin; Jiang, Zhou-hua; Li, Hua-bing; Liu, Fu-bin; Li, Xing

    With the rapid development of manufacture industry in China, die steels are in great need of large slab ingot of high quality and large tonnage, such as P20, WSM718R and so on. Solidification structure and size of large slab ingots produced with conventional methods are not satisfied. However, large slab ingots manufactured by ESR process have a good solidification structure and enough section size. In the present research, the new slab ESR process was used to produce the die steels large slab ingots with the maximum size of 980×2000×3200mm. The compact and sound ingot can be manufactured by the slab ESR process. The ultra-heavy plates with the maximum thickness of 410 mm can be obtained after rolling the 49 tons ingots. Due to reducing the cogging and forging process, the ESR for large slab ingots process can increase greatly the yield and production efficiency, and evidently cut off product costs.

  3. Dose response of artificial irradiation of fluvial sediment sample for ESR dating

    International Nuclear Information System (INIS)

    Liu Chunru; Yin Gongming; Gao Lu; Li Jianping; Han Fei; Lin Min

    2011-01-01

    ESR dating samples need be irradiated to obtain dose response curve and the equivalent dose. The artificial dose rate is about 1 x 10 -1 -1 x 10 2 Gy/min, whereas the natural dose rate is about 3 Gy/ka. Therefore, one must be sure whether the much higher artificial dose rate is suitable for the ESR dating study. In this paper, we use different artificial dose rate to irradiate the same fluvial sample and measure the quartz Al centre ESR signal under the same conditions. The dose response curves are compared, in an attempt to gain a preliminary knowledge on that problem and build a good foundation for our ESR dating studies on fluvial samples. (authors)

  4. Effect of surfactant coating on magnetic properties of Fe3O4 nanoparticles: ESR study

    International Nuclear Information System (INIS)

    Koeseoglu, Yueksel

    2006-01-01

    Magnetic properties of surfactant-coated and uncoated superparamagnetic iron oxide nanoparticles, Fe 3 O 4 (SPION) were investigated by electron spin resonance (ESR) technique. For all samples, a strong and broad single ESR signal has been observed at all temperatures. A strong temperature dependence of ESR linewidth and resonance field is observed. Also, there is a strong effect of surfactant coating on magnetic properties of Fe 3 O 4 nanoparticles. While the resonance field is decreasing by coating, the linewidth of the ESR spectra is increasing. These changes in resonance field and the linewidth are attributed to the decrease in effective magnetic moment due to a non-collinear spin structure originated from the pinning of the surface spins and coated surfactant at the interface of nanoparticles. Also, the changes are due to the contribution of the volume of the diamagnetic coating mass to the sample volume

  5. ESR analysis of natural and gamma irradiated coriander (Coriandrum sativum L.) seeds

    Science.gov (United States)

    Sezer, M. Özgür; Kaplan, Necati; Sayin, Ulku

    2017-12-01

    Electron spin resonance (ESR) is a powerful technique to detect radicals trapped in cellulosic food products and has been suggested as a useful method for identification of irradiated herbal foodstuffs. Coriander spice which has important medicinal properties was investigated using ESR spectroscopy. Radicals in natural and irradiated coriander samples were determined at room temperature. ESR spectra of natural sample were characterized by a single central signal with ? value and gamma irradiation produced satellite peaks attributed to cellulose-like radical which is used as a marker for detection of irradiated cellulosic plant products. The spectroscopic splitting values of radicals were determined. Dose dependency and stability of this center were analyzed by dose response and kinetic measurements. The reported results about activation energy, thermal life time and dose response relationship of the cellulose-like radical accurately prove that ESR can be used for identification of irradiated coriander spice seeds.

  6. Identification of irradiated sage tea (Salvia officinalis L.) by ESR spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Tepe Cam, Semra, E-mail: stepe06@gmail.co [Gazi University, Faculty of Medicine, Biophysics Department, 06500 Besevler, Ankara (Turkey); Engin, Birol [Turkish Atomic Energy Authority, Saraykoey Nuclear Research and Training Center, 06983 Ankara (Turkey)

    2010-04-15

    The use of electron spin resonance (ESR) spectroscopy to accurately distinguish irradiated from unirradiated sage tea was examined. Before irradiation, sage tea samples exhibit one asymmetric singlet ESR signal centered at g=2.0037. Besides this central signal, two weak satellite signals situated about 3 mT left and right to it in radiation-induced spectra. Irradiation with increasing doses caused a significant increase in radiation-induced ESR signal intensity at g=2.0265 (the left satellite signal) and this increase was found to be explained by a polynomial varying function. The stability of that radiation-induced ESR signal at room temperature was studied over a storage period of 9 months. Also, the kinetic of signal at g=2.0265 was studied in detail over a temperature range 313-353 K by annealing samples at different temperatures for various times.

  7. Dosimetric calibration of humidity chamber inside the 60Co-PANBIT irradiator using alanine ESR dosimeter

    International Nuclear Information System (INIS)

    Murali, S.; Venkataramani, R.; Pushparaja; Natarajan, V.; Sastry, M.D.; Bora, J.S.; Venkatacharyulu, K.

    1998-01-01

    In the present work the suitability of the electron spin resonance (ESR) technique, using DL - α - alanine sample is examined. It is well documented that radiation induced free radicals in alanine give strong ESR spectrum which can be used for dosimetry purposes. The aspects that are relevant to the present work are: (I) stability of the radicals in temperature and humidity conditions in which the experiments were carried out; (II) linearity at high doses; and (III) establishing the utility of alanine ESR dosimeter by cross checking the dose values with more established dosimeters. The details of these investigations are presented and it is shown that alanine ESR dosimeter will meet all the required conditions satisfactorily

  8. ESR-spin trapping studies on the interaction between anthraquinone triplets and aromatic compounds

    International Nuclear Information System (INIS)

    Moger, G.; Rockenbauer, A.; Simon, P.

    1980-01-01

    The ESR spin trapping technique was used for the detection of transient C-centered radicals in the photochemical interaction between triplet anthraquinone and aromatic hydroperoxide and alcohol. (author)

  9. The influence of different fitting functions on paleodose determination in ESR dating of tooth enamel-Taking Longgupo tooth fossils as an example

    International Nuclear Information System (INIS)

    Han Fei; Yin Gongming; Liu Chunru; Gao Lu; Li Jianping; Jean-Jacques Bahain; Tristan Garcia

    2011-01-01

    Paleodose determination is essential for ESR dating,and the D E value is influenced by the mathematical functions used for dose response data points fitting. At present, single saturation exponential (SSE) fitting is commonly used for ESR dating. It is valid when the number of trap sites is constant, but when the increasing irradiation dose induces new traps, the dose response curve will not follow a unique SSE function. In this study,in addition to SSE, the double saturation exponential (DSE) and exponential plus linear(EPL) functions were used to fit the ESR data of eight tooth fossil samples from Longgupo early Pleistocene site in Wushan, Chongqing.The results show that the D E values calculated by SSE fitting function are systematically higher than DSE and EPL, and the residual sum of square of SSE is larger than the other two. Compared with known reference dose value, we found that DSE has the smallest relative deviation among the three functions, and the SSE has the largest deviation. The study indicates that the SSE function overestimates D E value of tooth fossil samples from old sites, while the D E value determined by DSE functions seems closer to the true value of paleodose. (authors)

  10. Metal ion-organic compound for high sensitive ESR dosimetry

    International Nuclear Information System (INIS)

    Hassan, G.M.; Ikeya, Motoji

    2000-01-01

    A systematic study to find a tissue equivalent and high sensitive dosimeter material has been made to stimulate the field of ESR dosimetry. Lithium acetate dihydrate (Li-Ac·2H 2 O:CH 3 COOLi·2H 2 O) and lithium phosphate (Li-phosphate:Li 3 PO 4 ) were irradiated by γ-rays to study radicals with (ESR) in addition to magnesium lactate (Mg-lactate (CH 3 CH(OH)COO) 2 Mg) doped with nominal pure lithium lactate (Mg(Li)-lactate) and lithium lactate (CH 3 CH(OH)COOLi) doped with Mg-lactate (Li(Mg)-lactate). A triplet spectrum with intensity ratio of 1:2:1 in Li-Ac·2H 2 O was ascribed to acetate radical which has g=2.0031±0.0004 and hyperfine splitting of A/gβ=2.12±0.1 mT. The Li-phosphate spectrum shows splitting due to anisotropic g-factors of g par =2.0190±0.0005 and g perp =1.9974±0.0004. Quartet spectra with the intensity ratio of 1:3:3:1 in Mg(Li)-lactate and Li(Mg)-lactate were ascribed to lactate radicals with g-factors of 2.0032 ± 0.0004 and 2.0029 ± 0.0004 and the intensity ratio of 1:3:3:1 and A/gβ=1.92±0.06 and 1.82 ± 0.06 mT, respectively. The response to γ-ray dose and the thermal stability as well as the effect of UV-illumination have been studied. The obtained number of free radicals per 100 eV (G-values) were 0.4 ± 0.13, 1.02 ± 0.31, 1.35 ± 0.35 and 0.78 ± 0 for Li-Ac.2H 2 O, Li-phosphate, Mg(Li)-lactate, and Li(Mg)-lactate, respectively. The lifetimes were estimated from Arrhenius plots to be approximately 2.0 ± 0.6, 50.7 ± 20 and 10 ± 3.5 years for Li-phosphate, Mg(Li)-lactate and Li(Mg)-lactate, respectively. The lifetime for Li-Ac·2H 2 O cannot be estimated because of the decomposition by heating

  11. ESR/Alanine {gamma}-dosimetry in the 10-30 Gy range

    Energy Technology Data Exchange (ETDEWEB)

    Fainstein, C. E-mail: cfainstein@cab.cnea.gov.ar; Winkler, E.; Saravi, M

    2000-05-15

    We report Alanine Dosimeter preparation, procedures for using the ESR/Dosimetry method, and the resulting calibration curve for {gamma}-irradiation in the range from 10-30 Gy. We use calibration curve to measure the irradiation dose in {gamma}-irradiation of human blood, as required in Blood Transfusion Therapy. The ESR/Alanine results are compared against those obtained using the thermoluminescent dosimetry (TLD) method.

  12. Study by electron spin resonance (ESR) of 60 Co irradiated grains and farinaceous derivatives

    International Nuclear Information System (INIS)

    Catanni, Marta Mattos.

    1995-01-01

    The electron spin resonance (ESR) spectroscopy is being pointed out as one of the most promising techniques to determine whether a food has been irradiated. In this work, the ESR spectrum of paramagnetic radicals produced by gamma irradiation of grains and flour derivatives using a 60 Co source was investigated. Samples of grains (wheat and barley), flours (wheat, maniac, rye, soy bean and maize), bran and starch have been irradiated with doses between 0.2 and 70 KGy. It was shown that all varieties of grains and flours presented similar ESR spectra with variation in the free radicals signal intensity. Measurements at 9.5 and 34.5 GHz shown that spectra were composed probably by the superposition of four paramagnetic species with g-factors closed to that of the free electron (2 triplets, 1 doublet and 1 singlet). Hyperfine interactions and the correspondingly line widths were estimated through an spectrum computer simulation. It was established that ESR signal intensities increased with the irradiation dose for all samples. Up to the commercial admissible dose limit (1 kGy), the increase of ESR signal shown a linear behavior with the dose. The signal stability varied significantly with storage conditions and sample humidity. For 1 kGy-irradiated samples stored at room temperature and 14% humidity, the ESR radiation signals were possible to be detected up to 5 days after irradiation. When the same samples were stored at low temperatures (0 0 C) or freeze-dried (almost 0% humidity) the ESR signals were detected until 6 months after irradiation. Similar ESR spectrum found for grains and flours was obtained for diverse starchy food products. It was verified that it is possible to identify for a long time irradiated starchy foods when they are commercialized dehydrated or frozen. (author). 66 refs., 35 figs., 17 tabs

  13. The influence of measurement and storage conditions on alanine ESR dosimeters

    International Nuclear Information System (INIS)

    Alexandre, A.C.

    1992-01-01

    Alanine has several desirable properties as an ESR dosemeter e.g. tissue equivalence, low fading and an approximately linear response for doses up to 10 kGy. This work reports on a simple system to produce the alanine dosemeter, the signal intensity for a range of doses and energies, and the effect of the air humidity and the spectrometer settings on the ESR signal. (Author)

  14. An approach to calculating childhood body burdens of dibenzodioxins and dibenzofurans which accounts for age-dependent biological half lives

    Energy Technology Data Exchange (ETDEWEB)

    Paustenbach, D. [ChemRisk, San Francisco, CA (United States); Leung, H.W. [Leung, H.W. Private Consultant, Danbury, CT (United States); Scott, P. [ChemRisk, Pittsburgh, PA (United States); Kerger, B. [HSRI, Tallahassee, FL (United States)

    2004-09-15

    The purpose of this study is to apply an age-dependent half life model to examine the range of child (ages 0-7) body burdens that correspond to selected exposure scenarios involving background dietary and environmental doses of dioxins. The scenarios examined include breast-fed and nonbreast- fed infants feeding for 6 months, other dioxin uptake from foods through age 7, and exposures to urban residential soils at 1 ppb TCDD toxic equivalents (TEQ). These body burden estimates in children are then compared to the adult body burden estimates corresponding to the range of tolerable daily intakes (1 to 4 pg TEQ/kg-day) proposed by some U.S. and international regulatory/advisory groups.

  15. Characterization of phenolic pellets for ESR dosimetry in photon beam radiotherapy

    International Nuclear Information System (INIS)

    Gallo, Salvatore; Veronese, Ivan; Iacoviello, Giuseppina; Panzeca, Salvatore; Bartolotta, Antonio; Longo, Anna; Dondi, Daniele; Gueli, Anna Maria; Loi, Gianfranco; Mones, Eleonora; Marrale, Maurizio

    2017-01-01

    This work deals with the dosimetric features of a particular phenolic compound (IRGANOX 1076 registered ) for dosimetry of clinical photon beams by using electron spin resonance (ESR) spectroscopy. After the optimization of the ESR readout parameters (namely modulation amplitude and microwave power) to maximise the signal without excessive spectrum distortions, basic dosimetric properties of laboratory-made phenolic dosimeters in pellet form, such as reproducibility, dose-response, sensitivity, linearity and dose rate dependence were investigated. The dosimeters were tested by measuring the depth dose profile of a 6 MV photon beam. A satisfactory intra-batch reproducibility of the ESR signal of the manufactured dosimeters was obtained. The ESR signal proved to increase linearly with increasing dose in the investigated dose range 1-13 Gy. The presence of an intrinsic background signal limits the minimum detectable dose to a value of approximately 0.6 Gy. Reliable and accurate assessment of the dose was achieved, independently of the dose rate. Such characteristics, together with the fact that IRGANOX 1076 registered is almost tissue-equivalent, and the stability of the ESR signal, make these dosimeters promising materials for ESR dosimetric applications in radiotherapy. (orig.)

  16. Diffusion studies on permeable nitroxyl spin probes through bilayer lipid membranes: A low frequency ESR study

    International Nuclear Information System (INIS)

    Meenakumari, V.; Benial, A. Milton Franklin; Utsumi, Hideo; Ichikawa, Kazuhiro; Yamada, Ken-ichi; Hyodo, Fuminori; Jawahar, A.

    2015-01-01

    Electron spin resonance (ESR) studies were carried out for permeable 2mM 14 N-labeled deutrated 3 Methoxy carbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) in pure water and 1mM, 2mM, 3mM, 4mM concentration of 14N-labeled deutrated MC-PROXYL in 400mM concentration of liposomal solution by using a 300 MHz ESR spectrometer. The ESR parameters such as linewidth, hyperfine coupling constant, g-factor, partition parameter and permeability were reported for these samples. The line broadening was observed for the nitroxyl spin probe in the liposomal solution. The line broadening indicates that the high viscous nature of the liposomal solution. The partition parameter and permeability values indicate the maximum diffusion of nitroxyl spin probes in the bilayer lipid membranes at 2 mM concentration of nitroxyl radical. This study illustrates that ESR can be used to differentiate between the intra and extra- membrane water by loading the liposome vesicles with a lipid-permeable nitroxyl spin probe. From the ESR results, the spin probe concentration was optimized as 2mM in liposomal solution for ESR phantom studies/imaging, invivo and invitro experiments

  17. Characterization of phenolic pellets for ESR dosimetry in photon beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Gallo, Salvatore; Veronese, Ivan [Universita degli Studi di Milano, Department of Physics, Milan (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Milano (Italy); Iacoviello, Giuseppina [Hospital ARNAS-Civico, Medical Physics Department, Palermo (Italy); Panzeca, Salvatore [Universita degli Studi di Palermo, Department of Physics and Chemistry, Palermo (Italy); Istituto Nazionale di Fisica Nucleare-Sezione di Catania, Catania (Italy); Bartolotta, Antonio; Longo, Anna [Universita degli Studi di Palermo, Department of Physics and Chemistry, Palermo (Italy); Dondi, Daniele [Universita degli Studi di Pavia, Department of Chemistry, Pavia (Italy); Istituto Nazionale di Fisica Nucleare, Sezione di Pavia (Italy); Gueli, Anna Maria [Istituto Nazionale di Fisica Nucleare-Sezione di Catania, Catania (Italy); Universita degli Studi di Catania, Department of Physics and Astronomy, PH3DRA Laboratories, Catania (Italy); Loi, Gianfranco; Mones, Eleonora [Azienda Ospedaliero Universitaria Maggiore della Carita, Medical Physics Department, Novara (Italy); Marrale, Maurizio [Universita degli Studi di Palermo, Department of Physics and Chemistry, Palermo (Italy); Istituto Nazionale di Fisica Nucleare-Sezione di Catania, Catania (Italy); Universita degli Studi di Palermo, Advanced Technologies Network Center (ATeN Center), Palermo (Italy)

    2017-11-15

    This work deals with the dosimetric features of a particular phenolic compound (IRGANOX 1076 {sup registered}) for dosimetry of clinical photon beams by using electron spin resonance (ESR) spectroscopy. After the optimization of the ESR readout parameters (namely modulation amplitude and microwave power) to maximise the signal without excessive spectrum distortions, basic dosimetric properties of laboratory-made phenolic dosimeters in pellet form, such as reproducibility, dose-response, sensitivity, linearity and dose rate dependence were investigated. The dosimeters were tested by measuring the depth dose profile of a 6 MV photon beam. A satisfactory intra-batch reproducibility of the ESR signal of the manufactured dosimeters was obtained. The ESR signal proved to increase linearly with increasing dose in the investigated dose range 1-13 Gy. The presence of an intrinsic background signal limits the minimum detectable dose to a value of approximately 0.6 Gy. Reliable and accurate assessment of the dose was achieved, independently of the dose rate. Such characteristics, together with the fact that IRGANOX 1076 {sup registered} is almost tissue-equivalent, and the stability of the ESR signal, make these dosimeters promising materials for ESR dosimetric applications in radiotherapy. (orig.)

  18. ESR, electrochemical and cyclodextrin-inclusion studies of triazolopyridyl pyridyl ketones and dipyridyl ketones derivatives

    Science.gov (United States)

    Olea-Azar, C.; Abarca, B.; Norambuena, E.; Opazo, L.; Jullian, C.; Valencia, S.; Ballesteros, R.; Chadlaoui, M.

    2008-11-01

    The electron spin resonance (ESR) spectra of free radicals obtained by electrolytic reduction of triazolopyridyl pyridyl ketones and dipyridyl ketones derivatives were measured in dimethylsulfoxide (DMSO). The hyperfine patterns indicate that the spin density delocalization is dependent of the rings presented in the molecule. The electrochemistry of these compounds was characterized using cyclic voltammetry, in DMSO as solvent. When one carbonyl is present in the molecule one step in the reduction mechanism was observed while two carbonyl are present two steps were detected. The first wave was assigned to the generation of the correspondent free radical species, and the second wave was assigned to the dianion derivatives. The phase-solubility measurements indicated an interaction between molecules selected and cyclodextrins in water. These inclusion complexes are 1:1 with βCD, and HP-βCD. The values of Ks showed a different kind of complexes depending on which rings are included. AM1 and DFT calculations were performed to obtain the optimized geometries, theoretical hyperfine constants, and spin distributions, respectively. The theoretical results are in complete agreement with the experimental ones.

  19. Detection system for forward emitted XUV photons from relativistic ion beams at the ESR

    Energy Technology Data Exchange (ETDEWEB)

    Egelkamp, C.; Hannen, V.; Ortjohann, H.W.; Vollbrecht, J.; Weinheimer, C.; Winzen, D. [Institut fuer Kernphysik, Uni Muenster (Germany); Kuehl, T. [Institut fuer Kernchemie, Uni Mainz (Germany); GSI, Darmstadt (Germany); Helmholtz Institut Jena (Germany); Noertershaeuser, W. [Institut fuer Kernchemie, Uni Mainz (Germany); GSI, Darmstadt (Germany); Sanchez, R.; Winters, D. [GSI, Darmstadt (Germany); Stoehlker, T. [GSI, Darmstadt (Germany); Helmholtz Institut Jena (Germany); Uni Jena (Germany)

    2016-07-01

    Highly charged heavy ions stored at relativistic velocities provide a unique possibility to test atomic structure calculations. A possibility to investigate electron-electron correlations is the study of the {sup 3}P{sub 0} → {sup 3}P{sub 1} fine structure transition in Be-like Krypton ({sup 84}Kr{sup 32+}) in laser spectroscopy experiments. For this purpose Be-like krypton ions are stored in the experimental storage ring (ESR) at GSI at a velocity of β = 0.69. Through an anticollinear arrangement of the excitation laser and the ions the wavelength in the rest frame of the ions can be matched. After the excitation to the {sup 3}P{sub 1} level the ions immediately decay to the ground state, emitting λ ∼ 17 nm photons. Due to the Lorentz boost, the photons are emitted mainly in the forward direction and experience a Doppler shift to wavelengths < 10 nm. To collect these photons a moveable cathode plate with a central slit is brought into the beam line. The XUV photons mostly produce low energy secondary electrons on the plate which are electromagnetically guided onto a MCP detector. The design and working principle, as well as simulations and test measurements of the detector are presented.

  20. Expression of estrogen receptor α 36 (ESR36) in the hamster ovary throughout the estrous cycle: effects of gonadotropins.

    Science.gov (United States)

    Chakraborty, Prabuddha; Roy, Shyamal K

    2013-01-01

    Estradiol-17β (E) plays an important role in ovarian follicular development. Evidence indicates that some of the effect of E is mediated by the transmembrane estrogen receptor. In this study, we examined the spatio-temporal expression of recently discovered ERα36 (ESR36), a splice variant of Esr1 and a receptor for non-genomic E signaling, in the hamster ovary during the estrous cycle and the role of gonadotropins and ovarian steroid hormones in ESR36 expression. ESR36 expression was high on estrus (D1:0900 h) and declined precipitously by proestrus (D4:0900 h) and remained low up to D4:1600 h. Immunofluorescence findings corroborated immunoblot findings and revealed that ESR36 was expressed only in the cell membrane of both follicular and non-follicular cells, except the oocytes. Ovarian ESR36 was capable of binding to the E-affinity matrix, and have different molecular weight than that of the ESR1 or GPER. Hypophysectomy (Hx) resulted in a marked decline in ESR36 protein levels. FSH and LH, alone or combined, markedly upregulated ESR36 protein in Hx hamsters to the levels observed in D1 hamsters, but neither E nor P had any effect. Inhibition of the gonadotropin surge by phenobarbital treatment on D4:1100 h attenuated ESR36 expression in D1:0900 h ovaries, but the decline was restored by either FSH or LH replacement on D4 afternoon. This is the first report to show that ESR36, which is distinct from ESR1 or GPER is expressed in the plasma membrane of ovarian follicular and non-follicular cells, binds to E and its expression is regulated directly by the gonadotropins. In light of our previous findings, the results suggest that ovarian cells contain at least two distinct membrane estrogen receptors, such as GPER and ESR36, and strongly suggest for a non-genomic action of E regulating ovarian follicular functions.

  1. The 4π-collaboration at SIS/ESR

    International Nuclear Information System (INIS)

    Rami, F.

    1991-01-01

    A new generation of 4π experiments aiming at the investigation of the properties of compressed and heated nuclear matter produced in heavy-ion collisions in the incident energy range .1 to 2. GeV/nucleon, is presently starting at the SIS/ESR facility at GSI-Darmstadt. The new 4π-instrument is described. A first experiment was focused on the production of composite particles in central and semi central collisions of 197 Au+ 197 Au at incident energies between 100 and 800 MeV/nucleon. Preliminary results indicate that the charged particle multiplicity measurement alone cannot be used to select the most central collisions, and new selection criteria are suggested. They also show the ability of the detection system to sort out, with reasonable statistics, high degree multifragment events, i.e. events where a large fraction of the total initial charge is going into a few big clusters (Z≥6). (R.P.) 20 refs., 14 figs

  2. ESR dosimetry of optically bleached quartz grains extracted from Plio-Quaternary sediment: Evaluating some key aspects of the ESR signals associated to the Ti-centers

    International Nuclear Information System (INIS)

    Duval, Mathieu; Guilarte, Verónica

    2015-01-01

    The present study aims at investigating several key aspects of ESR dose reconstruction of quartz grains based on the analysis of the Ti-center: (i) the evaluation of the ESR intensity, (ii) its impact on measurements precision, and (iii) the potential of various fitting functions to describe the behavior of the signal with the radiation absorbed dose. In contrast with the Al center, the various Ti centers have quite low ESR signal intensities. It is thus crucial to adapt the experimental conditions for the optimization of the signal-to-noise ratio and to perform repeated measurements in order to take into consideration the uncertainty associated to angular dependence of the signal as well as day-to-day variations. Several options (named A to E) for evaluating the ESR intensity of the Ti–Li and Ti–H centers are explored and some of them yield too much experimental uncertainty (e.g. options C and E) and are apparently not suitable for accurate ESR dosimetry. In contrast, options A and D usually provide similar equivalent dose (D E ) results and can be used together for assessing the dose absorbed by the Ti–Li center. Our results show a systematic non-monotonic behavior of the ESR signal of the Ti center with the dose, which raise some questions about the suitability of the single saturating exponential (SSE) function that is classically used in ESR dating. Consequently, we explored the potential of other functions that can describe the “radiation bleaching” phenomenon observed at high doses. We recommend the use of a specific fitting function (called Ti-2 in the present paper) previously proposed by Woda and Wagner (2007) for any dose reconstruction, and define some criteria to ensure a good fitting. The SSE function provides D E results that are, in most cases, relatively consistent with those derived from the Ti-2, suggesting that the Ti centers apparently follow a SSE behavior up to, at least, 6.0–6.5 kGy However, the reliability of the D E values

  3. ESR dating at K and X band of northeastern Brazilian megafauna

    International Nuclear Information System (INIS)

    Kinoshita, Angela; Magnolia Franca, Alcina; Augusto Costa de Almeida, Jose; Maria Figueiredo, Ana; Nicolucci, Patricia; Graeff, Carlos F.O.; Baffa, Oswaldo

    2005-01-01

    The archaeological dose (AD) was measured in three tooth samples of giant mammals that belonged to Brazilian megafauna using electron spin resonance (ESR) spectroscopy at X-band (ν ∼9.5GHz) and K-band (ν ∼24GHz). Samples were collected in Lagoa de Dentro, Puxinana city in Paraiba, a northeast state in Brazil and were identified as Haplomastodon waringi (Holland) (two teeth) and one tooth sample of Xenorhinotherium bahiense (Cartele and Lessa). The average AD led to an age for the Haplomastodon samples of 11.6kybp. For one sample (Haplomastodon) K-band was also employed to evaluate the AD. The K-band spectrum had three components, determined using spectral simulation as follows: a wide isotropic line with g factor 2.0048, an orthorhombic line with gx=2.0034, gy=2.0022 and gz=1.9974, and another isotropic line with g factor 2.0008. The amplitude of these three signals increase with the added dose and the average dose found was 26+/-5Gy. This result is compatible with the AD determined with X-band 21+/-3Gy

  4. ESR dosimetry study for the residents of Kazakhstan exposed to radioactive fallout on 24, August 1956

    Energy Technology Data Exchange (ETDEWEB)

    Zhumadilov, K., E-mail: kassym@hiroshima-u.ac.jp [Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 (Japan); Ivannikov, A. [Medical Radiological Research Center, Obninsk 249036 (Russian Federation); Zharlyganova, D. [Astana Medical University, 51a, Beibitshilik str., Astana 010000 (Kazakhstan); Zhumadilov, Zh. [Nazarbayev University, Life Sciences Center, D. Kunayev str., Astana 010000 (Kazakhstan); Stepanenko, V. [Medical Radiological Research Center, Obninsk 249036 (Russian Federation); Abralina, Sh.; Sadvokasova, L. [Semey State Medical Academy, Semey 071400, Abay str. 103 (Kazakhstan); Zhumadilova, A. [Astana Medical University, 51a, Beibitshilik str., Astana 010000 (Kazakhstan); Toyoda, S. [Department of Applied Physics, Faculty of Science, Okayama University of Science, Okayama 700-0005 (Japan); Endo, S. [Department of Quantum Energy Applications, Graduated School of Engineering, Hiroshima University, 1-4-1 Kagamiyama, Higashi-Hiroshima 739-8527 (Japan); Okamoto, T. [Department of Molecular Oral Medicine and Maxillofacial Surgery, Division of Frontier Medical Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima 734-8553 (Japan); Hoshi, M. [Research Institute for Radiation Biology and Medicine, Hiroshima University, Kasumi 1-2-3, Minami-ku, Hiroshima 734-8553 (Japan)

    2011-09-15

    The method of electron spin resonance (ESR) dosimetry has been applied to human tooth enamel in order to obtain individual absorbed doses from the population of settlements within the vicinity of the central axis of the radioactive fallout trace from the contaminating nuclear surface test of 24, August 1956. Most of the settlements (Glubokoe, Tavriya, and Gagarino) are located near Ust-Kamenogorsk city, in Kazakhstan (about 400 km to the east from the epicenter of the explosion at the Semipalatinsk Nuclear Test Site (SNTS)). It was found that the excess doses obtained after the subtraction of natural background radiation ranged up to about 120 mGy for the residents of Ust-Kamenogorsk city, whose tooth enamel was formed before 1956. For the residents of Gagarino, excess doses do not exceed 47 mGy for all ages. For the residents of Tavriya, the maximum of excess dose was determined as 54 mGy and for the residents of Glubokoe, the maximum excess dose was about 83 mGy. For the population of the Shemonaikha settlements (about 70 km from the centerline of the radioactive fallout trace) the highest excess dose is 110 mGy. Also for this study, Znamenka village (about 130 km from the epicenter) was included. The Kokpekty settlement was chosen as a control and not subjected to any radioactive contamination and is located 400 km to the Southeast from SNTS.

  5. Effect of age-dependent bone electron density on the calculated dose distribution from kilovoltage and megavoltage photon and electron radiotherapy in paediatric MRI-only treatment planning.

    Science.gov (United States)

    Zeinali-Rafsanjani, B; Faghihi, R; Mosleh-Shirazi, M A; Saeedi-Moghadam, M; Jalli, R; Sina, S

    2018-01-01

    MRI-only treatment planning (TP) can be advantageous in paediatric radiotherapy. However, electron density extraction is necessary for dose calculation. Normally, after bone segmentation, a bulk density is assigned. However, the variation of bone bulk density in patients makes the creation of pseudo CTs challenging. This study aims to assess the effects of bone density variations in children on radiation attenuation and dose calculation for MRI-only TP. Bone contents of <15-year-old children were calculated, and substituted in the Oak Ridge National Laboratory paediatric phantoms. The percentage depth dose and beam profile of 150 kVp and 6 MV photon and 6 MeV electron beams were then calculated using Xcom, MCNPX (Monte Carlo N-particle version X) and ORLN phantoms. Using 150 kVp X-rays, the difference in attenuation coefficient was almost 5% between an 11-year-old child and a newborn, and ~8% between an adult and a newborn. With megavoltage radiation, the differences were smaller but still important. For an 18 MV photon beam, the difference of radiation attenuation between an 11-year-old child and a newborn was 4% and ~7.4% between an adult and a newborn. For 6 MeV electrons, dose differences were observed up to the 2 cm depth. The percentage depth dose difference between 1 and 10-year-olds was 18.5%, and between 10 and 15-year-olds was 24%. The results suggest that for MRI-only TP of photon- or electron-beam radiotherapy, the bone densities of each age group should be defined separately for accurate dose calculation. Advances in knowledge: This study highlights the need for more age-specific determination of bone electron density for accurate dose calculations in paediatric MRI-only radiotherapy TP.

  6. ESR signal features of 60Co γ-ray irradiated bone tissue and its dose response relationship

    International Nuclear Information System (INIS)

    Wu Ke; Sun Zunpu; Shi Yuanming

    1993-01-01

    Electron spin resonance (ESR) technique was used to study the radiation-induced ESR signal features of different paramagnetic species of 60 Co γ-ray irradiated bone tissue. The results showed that the intensity of an ESR signal at that the intensity of an ESR signal at g 2.0022 of human bones exposed to a dose range of 0-50 Gy had linear dose response relationships. The lower limit of detectable dose was about 2 Gy and the detecting error was about 10%. The signal was stable at room temperature during 60 days, and the effect of radiation dose rate of 0.5-8.0 Gy/min could be neglected. This signal was insensitive to microwave power and temperature, which was suitable for rapid and direct detection with ESR technique. These features suggest that human bones could be used for radiation accident dose evaluation by ESR

  7. Uncertainties in low γ-dose determinations by means of ESR using the biomaterial modern coral reef

    International Nuclear Information System (INIS)

    Hassan, Gamal M.; Sharaf, M.A.

    2006-01-01

    The ESR spectrum of unirradiated modern aragonite coral (CaCO 3 ) material from the Red Sea (Hurgada area) is characterized by four signals with spectroscopic splitting factors of g=2.0056, 2.0030, 2.0006 and 1.997. The most intensive and stable line in this spectrum is attributed to CO 2 - radicals at g=2.0006+/-0.0005. The dose response from 50mGy to 20Gy, energy dependence and effective atomic number are calculated so as to investigate coral as a dosimeter material in the clinical dose range. The lower experimental γ-dose limit was found to be 50mGy with signal-to-noise (S/N) ratio of 15. The combined and expanded uncertainties accompanying these measurements are 1.72% and 3.44%, respectively

  8. Uncertainties in low {gamma}-dose determinations by means of ESR using the biomaterial modern coral reef

    Energy Technology Data Exchange (ETDEWEB)

    Hassan, Gamal M. [Department of Ionizing Radiation Metrology, National Institute for Standards (NIS), Tersa Street El-Haram El-Giza, P.O. Box 136 Giza, El-Giza (Egypt)]. E-mail: gamalhassan65@hotmail.com; Sharaf, M.A. [Department of Ionizing Radiation Metrology, National Institute for Standards (NIS), Tersa Street El-Haram El-Giza, P.O. Box 136 Giza, El-Giza (Egypt)

    2006-01-15

    The ESR spectrum of unirradiated modern aragonite coral (CaCO{sub 3}) material from the Red Sea (Hurgada area) is characterized by four signals with spectroscopic splitting factors of g=2.0056, 2.0030, 2.0006 and 1.997. The most intensive and stable line in this spectrum is attributed to CO{sub 2}{sup -} radicals at g=2.0006+/-0.0005. The dose response from 50mGy to 20Gy, energy dependence and effective atomic number are calculated so as to investigate coral as a dosimeter material in the clinical dose range. The lower experimental {gamma}-dose limit was found to be 50mGy with signal-to-noise (S/N) ratio of 15. The combined and expanded uncertainties accompanying these measurements are 1.72% and 3.44%, respectively.

  9. Comparison of ESR1 Mutations in Tumor Tissue and Matched Plasma Samples from Metastatic Breast Cancer Patients

    Directory of Open Access Journals (Sweden)

    Takashi Takeshita

    2017-10-01

    Full Text Available BACKGROUND: ESR1 mutation in circulating cell-free DNA (cfDNA is emerging as a noninvasive biomarker of acquired resistance to endocrine therapy, but there is a paucity of data comparing the status of ESR1 gene in cfDNA with that in its corresponding tumor tissue. The objective of this study is to validate the degree of concordance of ESR1 mutations between plasma and tumor tissue. METHODS: ESR1 ligand-binding domain mutations Y537S, Y537N, Y537C, and D538G were analyzed using droplet digital PCR in 35 patients with metastatic breast cancer (MBC (35 tumor tissue samples and 67 plasma samples. RESULTS: Of the 35 paired samples, 26 (74.3% were concordant: one patient had detectable ESR1 mutations both plasma (ESR1 Y537S/Y537N and tumor tissue (ESR1 Y537S/Y537C, and 25 had WT ESR1 alleles in both. Nine (25.7% had discordance between the plasma and tissue results: five had mutations detected only in their tumor tissue (two Y537S, one Y537C, one D538G, and one Y537S/Y537N/D538G, and four had mutations detected only in their plasma (one Y537S, one Y537N, and two Y537S/Y537N/D538G. Furthermore, longitudinal plasma samples from 19 patients were used to assess changes in the presence of ESR1 mutations during treatment. Eleven patients had cfDNA ESR1 mutations over the course of treatment. A total of eight of 11 patients with MBC with cfDNA ESR1 mutations (72.7% had the polyclonal mutations. CONCLUSION: We have shown the independent distribution of ESR1 mutations between plasma and tumor tissue in 35 patients with MBC.

  10. New Approach For Detection Of Irradiated Spices Using Electron Spin Resonance (ESR)

    International Nuclear Information System (INIS)

    FARAG, S.A.; SHAMS EL DIEEN, N.M.M.

    2010-01-01

    Black pepper and anise samples were irradiated with different doses of gamma rays (5, 10 and 20 kGy) then the irradiated samples were stored at room temperature (20 0 C, 70-75 % RH) for one year. The measurements of free radicals were carried out by electron spin resonance (ESR) at different intervals (3, 6, 9 and 12 months). A series of signals tentatively described as cellulose-like and complex radical observed at G values were 2.01027 for black pepper and 2.01019 for anise. The ESR signals of irradiated spices showed a directly proportional relationship for increasing dose with increasing intensity of signal. A relationship was noticed as polynomial regression analysis resulted between signals of ESR intensity and applied doses with significant values of correlation coefficient (R 2 ). All combination treatments of thermal and irradiation beside long storage caused significant reduction of ESR intensity of irradiated black pepper and anise. Upon using low doses as 1, 2 and 3 kGy for re-irradiation, the irradiated samples (10 and 20 kGy) increased the power of ESR intensity. The enhancement effect was markedly increased. For example, the irradiated black pepper (10 kGy) increased the ESR intensity with high percentages as 49.19%, 69.23% and 89.68% while the high dose (20 kGy) caused increase by 39.96%, 69.05% and 96.90% for irradiated black pepper samples. This approach with that technique can be used easily to overcome the main disadvantages of ESR signals fading especially at the end of storage period.

  11. Reflectivity quenching of ESR multilayer polymer film reflector in optically bonded scintillator arrays

    Science.gov (United States)

    Loignon-Houle, Francis; Pepin, Catherine M.; Charlebois, Serge A.; Lecomte, Roger

    2017-04-01

    The 3M-ESR multilayer polymer film is a widely used reflector in scintillation detector arrays. As specified in the datasheet and confirmed experimentally by measurements in air, it is highly reflective (> 98 %) over the entire visible spectrum (400-1000 nm) for all angles of incidence. Despite these outstanding characteristics, it was previously found that light crosstalk between pixels in a bonded LYSO scintillator array with ESR reflector can be as high as ∼30-35%. This unexplained light crosstalk motivated further investigation of ESR optical performance. Analytical simulation of a multilayer structure emulating the ESR reflector showed that the film becomes highly transparent to incident light at large angles when surrounded on both sides by materials of refractive index higher than air. Monte Carlo simulations indicate that a considerable fraction (∼25-35%) of scintillation photons are incident at these leaking angles in high aspect ratio LYSO scintillation crystals. The film transparency was investigated experimentally by measuring the scintillation light transmission through the ESR film sandwiched between a scintillation crystal and a photodetector with or without layers of silicone grease. Strong light leakage, up to nearly 30%, was measured through the reflector when coated on both sides with silicone, thus elucidating the major cause of light crosstalk in bonded arrays. The reflector transparency was confirmed experimentally for angles of incidence larger than 60 ° using a custom designed setup allowing illumination of the bonded ESR film at selected grazing angles. The unsuspected ESR film transparency can be beneficial for detector arrays exploiting light sharing schemes, but it is highly detrimental for scintillator arrays designed for individual pixel readout.

  12. The high-frequency ESR spectra of the syntetic diamond and nanodiamonds type Ib at low temperature

    International Nuclear Information System (INIS)

    Khatsko, E.; Kobets, M.; Dergachev, K.; Kulbickas, A.; Rasteniene, L.; Vaisnoras, R.

    2013-01-01

    The ESR absorption spectra of nonirradiated and irradiated (by electrons with an energy of 2 MeV) bulk diamond and nanodiamond powder of type Ib have been studied at a wide range of frequencies (70-20 GHz) and temperature (4.2-0 K) by ESR method. It is shown, that in the ESR spectrum of bulk diamond absorption lines of ion nickel catalyst Ni +a nd a paramagnetic single center of the nitrogen N 0 is observed. Absorption lines of the paramagnetic centers with dangling bonds on the nanodiamond surface (surface defects) in the ESR spectra are obtained.

  13. Comparing calculated free testosterone with total testosterone for screening and diagnosing late-onset hypogonadism in aged males: A cross-sectional study.

    Science.gov (United States)

    Liu, Zhangshun; Liu, Jie; Shi, Xiaohong; Wang, Lihong; Yang, Yan; Tao, Minfang; Fu, Qiang

    2017-09-01

    The aim of this study is to compare calculated free testosterone (cFT) and total testosterone (T) in predicting late-onset hypogonadism (LOH) in middle-aged and elderly males. We surveyed a random sample of 608 males between the ages of 45 and 87 years from Shanghai, China. The Aging Male Symptoms (AMS) questionnaire and the Androgen Deficiency in Aging Male (ADAM) questionnaire were completed by the subjects. Testosterone (T), sex hormone-binding globulin (SHBG), albumin, and other blood biochemical indexes were measured in 332 males. The corresponding cFT was obtained using the Vermeulen formula and the correlations between T and cFT were analyzed by SPSS statistical software. Among the 332 males who underwent biochemical evaluation, 289 males (87.0%) was positively screened by the ADAM questionnaire and 232 males (69.9%) by the AMS questionnaire. As suggested by linear regression, cFT exhibited a negative correlation with age in both ADAM+ and AMS+ group, whereas T did not appear to have significant correlation with age. Besides, there were statistically significant differences in cFT (Pmales. © 2016 Wiley Periodicals, Inc.

  14. Age

    Science.gov (United States)

    ... adults? How can you reduce anesthesia risks in older patients? Age Age may bring wisdom but it also brings ... Ask your physician to conduct a pre-surgery cognitive test — an assessment of your mental function. The physician can use the results as a ...

  15. Applying Costs, Risks and Values Evaluation (CRAVE) methodology to Engineering Support Request (ESR) prioritization

    Science.gov (United States)

    Joglekar, Prafulla N.

    1994-01-01

    Given limited budget, the problem of prioritization among Engineering Support Requests (ESR's) with varied sizes, shapes, and colors is a difficult one. At the Kennedy Space Center (KSC), the recently developed 4-Matrix (4-M) method represents a step in the right direction as it attempts to combine the traditional criteria of technical merits only with the new concern for cost-effectiveness. However, the 4-M method was not adequately successful in the actual prioritization of ESRs for the fiscal year 1995 (FY95). This research identifies a number of design issues that should help us to develop better methods. It emphasizes that given the variety and diversity of ESR's one should not expect that a single method could help in the assessment of all ESR's. One conclusion is that a methodology such as Costs, Risks, and Values Evaluation (CRAVE) should be adopted. It also is clear that the development of methods such as 4-M requires input not only from engineers with technical expertise in ESR's but also from personnel with adequate background in the theory and practice of cost-effectiveness analysis. At KSC, ESR prioritization is one part of the Ground Support Working Teams (GSWT) Integration Process. It was discovered that the more important barriers to the incorporation of cost-effectiveness considerations in ESR prioritization lie in this process. The culture of integration, and the corresponding structure of review by a committee of peers, is not conducive to the analysis and confrontation necessary in the assessment and prioritization of ESR's. Without assistance from appropriately trained analysts charged with the responsibility to analyze and be confrontational about each ESR, the GSWT steering committee will continue to make its decisions based on incomplete understanding, inconsistent numbers, and at times, colored facts. The current organizational separation of the prioritization and the funding processes is also identified as an important barrier to the

  16. ESR and TL studies of irradiated Anatolian laurel leaf (Laurus nobilis L.)

    Science.gov (United States)

    Tepe Çam, Semra; Aydaş, Canan; Engin, Birol; Rabia Yüce, Ülkü; Aydın, Talat; Polat, Mustafa

    2012-06-01

    Laurel leaf (Laurus nobilis L.) samples that originated from Turkey were analyzed by electron spin resonance (ESR) and thermoluminescence (TL) techniques before and after γ-irradiation. Unirradiated (control) laurel leaf samples exhibit a weak ESR singlet centered at g=2.0020. Besides this central signal were two weak satellite signals situated about 3 mT left and right to it in radiation-induced spectra. The dose-response curve of the radiation-induced ESR signal at g=2.0187 (the left satellite signal) was found to be described well by a power function. Variation of the left satellite ESR signal intensity of irradiated samples at room temperature with time in a long term showed that cellulosic free radicals responsible for the ESR spectrum of laurel leaves were not stable but detectable even after 100 days. Annealing studies at four different temperatures were used to determine the kinetic behavior and activation energy of the radiation-induced cellulosic free radicals responsible from the left satellite signal (g=2.0187) in laurel leaves. TL measurements of the polymineral dust isolated from the laurel leaf samples allowed distinguishing between irradiated and unirradiated samples.

  17. The role of IL6 and ESR1 gene polymorphisms as immunological factors of pregnancy maintenance

    Directory of Open Access Journals (Sweden)

    Kucherenko A. M.

    2013-09-01

    Full Text Available Aim. The study is aimed at the evaluation of the association of IL6 gene -174G/C polymorphism and ESR1 gene -397C/T polymorphism with recurrent pregnancy loss (RPL pathogenesis and at the investigation of the ESR1 gene -397C/T variant regulatory significance for the IL6 gene function. Methods. A case group of 75 women with RPL history and a control group of 106 unrelated healthy women, who have given birth to at least one child conceived in natural way, were genotyped by a PCR based restriction fragment length polymorphism assay. Results. There was no significant difference in IL6 -174G/C or ESR1 -397C/T genotype and allele frequencies between the case and control groups. Combined genotype distribution analysis showed significantly (p < 0.05 lower frequency of individuals homozygous for both IL6 -174G and ESR1 -397C alleles in case group (0.026 comparing to control (0.094. Conclusions. Genotype comprising IL6 -174G and ESR1 -397C alleles in homozygous state may be considered as a genetic marker of successful pregnancy maintenance during gestation early stages.

  18. ESR investigation of L-α-alanine and sucrose radicals produced by heavy-ion irradiation

    International Nuclear Information System (INIS)

    Nakagawa, K.; Sato, Y.

    2005-01-01

    We investigated sucrose and L-α-alanine radicals produced by heavy (particle) ion irradiation with various LETs (linear energy transfer). The impact of the heavy ions on the samples produced stable free radicals, which were analyzed by ESR (electron spin resonance). Identical spectra were measured after one year. The obtained spectral patterns were the same as those for helium (He), carbon (C), and neon (Ne) ions irradiation. The absorbed dose dependences for the irradiated sucrose and alanine samples were examined. The ESR response has a linear relation with the absorbed dose. The ESR response at 60 Gy was slightly lower than a linear line for sucrose; however, the response showed good linearity for the alanine. In addition, the total spin concentration obtained by heavy-ion irradiation correlated logarithmically with the LET. Qualitative ESR analyse showed that the production of sucrose and alanine radicals depended on both different particle irradiation and the LET under the same dose. Thus, the present ESR results imply that sucrose together with L-α-alanine can be used to monitor LET as well as the number of ionizing particle for the production of stable free radicals. (author)

  19. Development of portable ESR spectrometer as a reader for alanine dosimeters

    International Nuclear Information System (INIS)

    Kojima, T.; Haruyama, Y.; Tachibana, H.; Tanaka, R.; Okamoto, J.

    1993-01-01

    A prototype portable electron spin resonance (ESR) spectrometer was designed and tested, and its feasibility as a reader of alanine dosimeters was studied from the two standpoints of reproducibility of readings and sensitivity sufficient for dosimetry in the absorbed dose range 1-100 kGy. It has two main components: a permanent magnet and resonator; and a unit box with a microwave and auto-frequency control (AFC) circuit, a sweep controller of magnetic field, display, etc. In the present preliminary study, reproducibility values are measured with the same ESR parameters and alanine-polystyrene (alanine-PS) dosimeter at a dose of 1 kGy: repeatedly measuring without removing dosimeter from the cavity; individual measurement with removing and inserting again into the cavity with readjustment of ESR parameters. Alanine/ESR dosimetry using this spectrometer has a measurable dose range from 1 to 100 kGy with relatively high precision within ± 3% (1σ) as a preliminary result. The portable ESR spectrometer may also be modified as an automatic, more precise, dedicated alanine dosimeter reader. (author)

  20. ESR imaging for estimation oxidative stress in the brain of rats

    Energy Technology Data Exchange (ETDEWEB)

    Yokoyama, Hidekatsu; Itoh, Osam; Aoyama, Masaaki; Obara, Heitaro; Ohya, Hiroaki; Kamada, Hitoshi [Inst. for Life Support Technology, Matsuei, Yamagata (Japan)

    2002-04-01

    ESR imaging for estimating intracerebral oxidative stress of rats was performed. An acyl-protected hydroxylamine, 1-acetoxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine (ACP), is a very stable non-radical compound outside cells, however, within cells, it is easily deprotected with esterase to yield 1-hydroxy-3-carbamoyl-2,2,5,5-tetramethylpyrrolidine, which is oxidized by oxidative stress to yield an ESR-detectable stable nitroxide radical, 3-carbamoyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl. Thus signal intensity in the ESR image reflects the strength of intracellular oxidative stress. From in vivo ESR image data of the brain of rats that received ACP, the average values of ESR signal intensity from the hippocampus, striatum, and cerebral cortex were computed. This imaging technique was applied to an epileptic seizure model. As a result, it was found that following a kainic acid-induced seizure, the oxidative stress in the hippocampus and striatum is enhanced, but not so in the cerebral cortex. (author)

  1. Using a Novel Absolute Ontogenetic Age Determination Technique to Calculate the Timing of Tooth Eruption in the Saber-Toothed Cat, Smilodon fatalis.

    Directory of Open Access Journals (Sweden)

    M Aleksander Wysocki

    Full Text Available Despite the superb fossil record of the saber-toothed cat, Smilodon fatalis, ontogenetic age determination for this and other ancient species remains a challenge. The present study utilizes a new technique, a combination of data from stable oxygen isotope analyses and micro-computed tomography, to establish the eruption rate for the permanent upper canines in Smilodon fatalis. The results imply an eruption rate of 6.0 millimeters per month, which is similar to a previously published average enamel growth rate of the S. fatalis upper canines (5.8 millimeters per month. Utilizing the upper canine growth rate, the upper canine eruption rate, and a previously published tooth replacement sequence, this study calculates absolute ontogenetic age ranges of tooth development and eruption in S. fatalis. The timing of tooth eruption is compared between S. fatalis and several extant conical-toothed felids, such as the African lion (Panthera leo. Results suggest that the permanent dentition of S. fatalis, except for the upper canines, was fully erupted by 14 to 22 months, and that the upper canines finished erupting at about 34 to 41 months. Based on these developmental age calculations, S. fatalis individuals less than 4 to 7 months of age were not typically preserved at Rancho La Brea. On the whole, S. fatalis appears to have had delayed dental development compared to dental development in similar-sized extant felids. This technique for absolute ontogenetic age determination can be replicated in other ancient species, including non-saber-toothed taxa, as long as the timing of growth initiation and growth rate can be determined for a specific feature, such as a tooth, and that growth period overlaps with the development of the other features under investigation.

  2. Using a Novel Absolute Ontogenetic Age Determination Technique to Calculate the Timing of Tooth Eruption in the Saber-Toothed Cat, Smilodon fatalis.

    Science.gov (United States)

    Wysocki, M Aleksander; Feranec, Robert S; Tseng, Zhijie Jack; Bjornsson, Christopher S

    2015-01-01

    Despite the superb fossil record of the saber-toothed cat, Smilodon fatalis, ontogenetic age determination for this and other ancient species remains a challenge. The present study utilizes a new technique, a combination of data from stable oxygen isotope analyses and micro-computed tomography, to establish the eruption rate for the permanent upper canines in Smilodon fatalis. The results imply an eruption rate of 6.0 millimeters per month, which is similar to a previously published average enamel growth rate of the S. fatalis upper canines (5.8 millimeters per month). Utilizing the upper canine growth rate, the upper canine eruption rate, and a previously published tooth replacement sequence, this study calculates absolute ontogenetic age ranges of tooth development and eruption in S. fatalis. The timing of tooth eruption is compared between S. fatalis and several extant conical-toothed felids, such as the African lion (Panthera leo). Results suggest that the permanent dentition of S. fatalis, except for the upper canines, was fully erupted by 14 to 22 months, and that the upper canines finished erupting at about 34 to 41 months. Based on these developmental age calculations, S. fatalis individuals less than 4 to 7 months of age were not typically preserved at Rancho La Brea. On the whole, S. fatalis appears to have had delayed dental development compared to dental development in similar-sized extant felids. This technique for absolute ontogenetic age determination can be replicated in other ancient species, including non-saber-toothed taxa, as long as the timing of growth initiation and growth rate can be determined for a specific feature, such as a tooth, and that growth period overlaps with the development of the other features under investigation.

  3. Calculation of apparent age by linear combination of facial skin parameters: a predictive tool to evaluate the efficacy of cosmetic treatments and to assess the predisposition to accelerated aging.

    Science.gov (United States)

    Dicanio, Denise; Sparacio, Rose; Declercq, Lieve; Corstjens, Hugo; Muizzuddin, Neelam; Hidalgo, Julie; Giacomoni, Paolo U; Jorgensen, Lise; Maes, Daniel

    2009-12-01

    The estimated apparent age (EAA) was estimated by a panel of trained experts, for the individuals in a cohort. Twelve independent clinical, biophysical and biochemical parameters measured on facial skin, have been identified by multiple regression analysis, which influence the EAA of a person of chronological age (CA) (under eye lines, clinically assessed crow's feet, age spots, clinically evaluated firmness, forehead lines, pores, lip lines, instrumentally evaluated firmness, instrumentally evaluated crow feet, skin texture, in vivo fluorescence related to proliferation and glycation). An algorithm has been devised to obtain the calculated age score (CAS) in a cohort of 452 female volunteers, as CAS(n) = ∑RCiPi(n) (i = 1-13, n = 1-452 and P13 = 1) where the coefficients Ci are obtained by minimizing the difference EAA - CAS, and Pi(n) are the experimental values of the i-th parameter for the n-th volunteer. The determination of CAS before and after a specific cosmetic or pharmacological anti-aging treatment can be used to objectively assess the efficacy of the treatment. The comparison of EAA(n) and of CAS(n) with CA(n) allows one to predict the susceptibility of an individual's face to undergo aging. It has been observed that the biophysical and biochemical parameters play a relevant role in the assessment of the predisposition of skin to undergo accelerated aging.

  4. Coupled {sup 230}Th/{sup 234}U-ESR analyses for corals: A new method to assess sealevel change

    Energy Technology Data Exchange (ETDEWEB)

    Blackwell, Bonnie A.B. [Department of Chemistry, Williams College, Williamstown, MA 01267 (United States); RFK Science Research Institute, Glenwood Landing, NY 11547 (United States)], E-mail: bonnie.a.b.blackwell@williams.edu; Teng, Steve J.T. [RFK Science Research Institute, Glenwood Landing, NY 11547 (United States)], E-mail: mteng1584@gmail.com; Lundberg, Joyce A. [Department of Geography and Environmental Studies, Carleton University, Ottawa, ON, Canada K1S 5B6 (Canada)], E-mail: joyce_lundberg@carleton.ca; Blickstein, Joel I.B. [Department of Chemistry, Williams College, Williamstown, MA 01267 (United States); RFK Science Research Institute, Glenwood Landing, NY 11547 (United States); Skinner, Anne R. [Department of Chemistry, Williams College, Williamstown, MA 01267 (United States); RFK Science Research Institute, Glenwood Landing, NY 11547 (United States)], E-mail: anne.r.skinner@williams.edu

    2007-07-15

    Although coupled {sup 230}Th/{sup 234}U-ESR analyses have become routine for dating teeth, they have never been used for corals. While the ESR age depends on, and requires assumptions about, the time-averaged cosmic dose rate, D-bar{sub cos}(t), {sup 230}Th/{sup 234}U dates do not. Since D-bar{sub cos}(t) received by corals depends on the attenuation by any intervening material, D-bar{sub cos}(t) response reflects changing water depths and sediment cover. By coupling the two methods, one can determine the age and a unique D-bar{sub cos,coupled}(t) simultaneously. From a coral's water depth and sedimentary history as predicted by a given sealevel curve, one can predict D-bar{sub cos,sealevel}(t). If D-bar{sub cos,coupled}(t) agrees well with D-bar{sub cos,sealevel}(t), this provides independent validation for the curve used to build D-bar{sub cos,sealevel}(t). For six corals dated at 7-128 ka from Florida Platform reef crests, the sealevel curve by Waelbroeck et al. [2002. Sea-level and deep water temperature changes derived from benthonic foraminifera isotopic records. Quat. Sci. Rev. 21, 295-305] predicted their D-bar{sub cos,coupled}(t) values as well as, or better than, the SPECMAP sealevel curve. Where a whole reef can be sampled over a transect, a precise test for sealevel curves could be developed.

  5. Aging

    International Nuclear Information System (INIS)

    Sasaki, Hideo; Kodama, Kazunori; Yamada, Michiko

    1991-01-01

    The hypothesis that exposure to ionizing radiation accelerates the aging process has been actively investigated at ABCC-RERF since 1958, when longitudinal cohort studies of the Adult Health Study (AHS) and the Life Span Study (LSS) were initiated. In their 1975 overall review of aging studies related to the atomic bomb (A-bomb) survivors, Finch and Beebe concluded that while most studies had shown no correlation between aging and radiation exposure, they had not involved the large numbers of subjects required to provide strong evidence for or against the hypothesis. Extending LSS mortality data up to 1978 did not alter the earlier conclusion that any observed life-shortening was associated primarily with cancer induction rather than with any nonspecific cause. The results of aging studies conducted during the intervening 15 years using data from the same populations are reviewed in the present paper. Using clinical, epidemiological, and laboratory techniques, a broad spectrum of aging parameters have been studied, such as postmortem morphological changes, tests of functional capacity, physical tests and measurements, laboratory tests, tissue changes, and morbidity. With respect to the aging process, the overall results have not been consistent and are generally thought to show no relation to radiation exposure. Although some preliminary results suggest a possible radiation-induced increase in atherosclerotic diseases and acceleration of aging in the T-cell-related immune system, further study is necessary to confirm these findings. In the future, applying the latest gerontological study techniques to data collected from subjects exposed 45 years ago to A-bomb radiation at relatively young ages will present a new body of data relevant to the study of late radiation effects. (author) 103 refs

  6. Researches and Applications of ESR Dosimetry for Radiation Accident Dose Assessment

    International Nuclear Information System (INIS)

    Wu, K.; Guo, L.; Cong, J.B.; Sun, C.P.; Hu, J.M.; Zhou, Z.S.; Wang, S.; Zhang, Y.; Zhang, X.; Shi, Y.M.

    1998-01-01

    The aim of this work was to establish methods suitable for practical dose assessment of people involved in ionising radiation accidents. Some biological materials of the human body and materials possibly carried or worn by people were taken as detection samples. By using electron spin resonance (ESR) techniques, the basic dosimetric properties of selected materials were investigated in the range above the threshold dose of human acute haemopoietic radiation syndrome. The dosimetric properties involved included dose response properties of ESR signals, signal stabilities, distribution of background signals, the lowest detectable dose value, radiation conditions, environmental effects on the detecting process, etc. Several practical dose analytical indexes and detecting methods were set up. Some of them (bone, watch glass and tooth enamel) had also been successfully used in the dose assessment of people involved in three radiation accidents, including the Chernobyl reactor accident. This work further proves the important role of ESR techniques in radiation accident dose estimation. (author)

  7. ESR dosimetry below 1 Gy, in X-ray irradiated tooth enamel

    International Nuclear Information System (INIS)

    Fainstein, Carlos; Winkler, Elin

    2000-01-01

    Tooth enamel, extracted from molars, was irradiated with 66 keV X-rays, with doses up to 1 Gy. The preparation of the powder samples is described, as well as the protocol for the acquisition and processing of the spectra. The radiation induced paramagnetism is measured, at room temperature, by ESR Spectroscopy. The ESR spectra is well described considering two paramagnetic species, with magnetic moments (in units of Bohr magneton) g=2,0041, and g 1 =2,0018, g 2 =1,9972. The ESR data (peak-to-peak amplitude per mg, hpp/mg, vs dose D), for doses 0 Gy 2 =0,996) with the linear expression: [hpp/mg] = -0,2(0,4)+14,9(0,5). D [Gy]. The result supports the growing confidence in the use of this material, and method, in Retrospective Dosimetry. (author)

  8. ESR Dosimetry Below 1 Gy, in X-Ray Irradiated Tooth Enamel

    International Nuclear Information System (INIS)

    Fainstein, Carlos; Winkler, E; Dubner, D; Gisone, P; Perez, M.R; Saravi, M; Alvarez, P; Davila, F

    2000-01-01

    Tooth enamel, extracted from molars, was irradiated with 66keV X-rays, with doses up to 1Gy.The preparation of the powder samples is described, as well as the protocol for the acquisition and processing of the spectra.The radiation induced paramagnetism is measured, at room temperature, by ESR Spectroscopy.The ESR spectra is well described considering two paramagnetic species, with magnetic moments (in units of Bohr magnetons) g=2,0041, and g1=2,0018, g2=1,9972.The ESR data (peak-to-peak amplitude per mg, hpp/mg, vs dose D), for doses 0Gy 2 =0,996) with the linear expression: [hpp/mg] = -0,2( 0,4)+14,9(0,5). D [Gy].The result supports the growing confidence in the use of this material, and method, in Retrospective Dosimetry

  9. An ESR study of the spectra of paint pigments in 'drying' linseed oil

    International Nuclear Information System (INIS)

    Slogett, R.; Troup, G.; Hutton, D.

    1999-01-01

    Full text: Since previous ESR work on the identification of RAW paint pigments, mainly mineral, looked promising, we decided to examine the spectra when the pigments were applied, in oil, to a non-reactive, microwave transparent polymer. The polymer used shows no significant ESR signals in the range 2000-4000 gauss at ∼9.1 GHz and room temperature. The oil used is Winsor and Newton Drying Linseed Oil, and contains 'manganese driers'. The spectrum of the pure liquid oil is shown, as well as that of the dried oil on the substrate. Many of the pigment spectra shown are so strong that not a trace of the oil Mn(2+) can be seen at the pigment concentrations used. The effect of the linseed oil on modern synthetic indigo, an organic pigment still available made from plants, is also shown. ESR still looks to be a useful supplementary technique for paint pigment identification

  10. The spectroscopic analysis of {gamma}-irradiated glass by colorimetry, ESR and XPS

    Energy Technology Data Exchange (ETDEWEB)

    Hong, S.I. [College of Life Sciences and Biotechnology, Korea University, 5 ga Anam-dong, Seongbuk-Gu, Seoul 135-701 (Korea, Republic of); Lee, Y.N. [R and D Institute Biscuit Team, 131-1, Namyoung-dong, Youngsan-Gu, Seoul 140-708 (Korea, Republic of); Cho, S.Y. [College of Life Sciences and Biotechnology, Korea University, 5 ga Anam-dong, Seongbuk-Gu, Seoul 135-701 (Korea, Republic of); Whiteside, W.S. [Department of Packaging Science, 226 Poole Agricultural Center, Clemson University, Clemson, SC 29634-0320 (United States); Park, H.J. [College of Life Sciences and Biotechnology, Korea University, 5 ga Anam-dong, Seongbuk-Gu, Seoul 135-701 (Korea, Republic of)], E-mail: hjpark@korea.ac.kr

    2008-09-15

    The darkening of {gamma}-irradiated glass was related to the binding of Si-O and Sn-O, and the binding of Na-O. The dosimetric range of glass color change was evaluated by colorimetry, UV-Vis spectrophotometry and ESR. Colorimetry and UV-Vis spectrophotometry, revealed linear changes up to 9 kGy. For the calibration curve of {gamma}-irradiation, the signal of g=2.01 observed by ESR responded most sensitively with a linear increase with up to 12 kGy.

  11. The spectroscopic analysis of γ-irradiated glass by colorimetry, ESR and XPS

    International Nuclear Information System (INIS)

    Hong, S.I.; Lee, Y.N.; Cho, S.Y.; Whiteside, W.S.; Park, H.J.

    2008-01-01

    The darkening of γ-irradiated glass was related to the binding of Si-O and Sn-O, and the binding of Na-O. The dosimetric range of glass color change was evaluated by colorimetry, UV-Vis spectrophotometry and ESR. Colorimetry and UV-Vis spectrophotometry, revealed linear changes up to 9 kGy. For the calibration curve of γ-irradiation, the signal of g=2.01 observed by ESR responded most sensitively with a linear increase with up to 12 kGy

  12. Regeneration of phenolic antioxidants from phenoxyl radicals: An ESR and electrochemical study of antioxidant hierarchy

    DEFF Research Database (Denmark)

    Jørgensen, Lars V.; Madsen, Helle L.; Thomsen, Marianne K.

    1999-01-01

    Radicals from the flavonoids quercetin, (+)-catechin, (+/-)-taxifolin and luteolin, and from all-rac-alpha-tocopherol have been generated electrochemically by one-electron oxidation in deaerated dimethylformamide (DMF), and characterised by electron spin resonance spectroscopy (ESR) after spin......-trapping by 5,5-dimethyl-1-pyrroline-N-oxide (DMPO). Simulations of the ESR spectrum based on estimated coupling constants of the spin-trapped quercetin radical, confirmed that this antioxidant radical is oxygen-centered. The complex mixture of radicals, quinoid intermediates and stable two-electron oxidation...

  13. A 3D- and 4D-ESR imaging system for small animals

    International Nuclear Information System (INIS)

    Oikawa, K.; Ogata, T.; Togashi, H.; Yokoyama, H.; Ohya-Nishiguchi, H.; Kamada, H.

    1996-01-01

    A new version of in vivo ESR-CT system composed of custom-made 0.7 GHz ESR spectrometer, air-core magnet with a field-scanning coil, three field-gradient coils, and two computers enables up-and down-field, and rapid magnetic-field scanning linearly controlled by computer. 3D-pictures of distribution of nitroxide radicals injected in brains and livers of rats and mice were obtained in 1.5 min with resolution of 1 mm. We have also succeeded in obtaining spatial-time imagings of the animals. (author)

  14. The use of ESR spectroscopy for the identification of irradiated food

    Energy Technology Data Exchange (ETDEWEB)

    Gray, R [Dept. of Agriculture for Northern Ireland, Belfast (United Kingdom). Food and Agricultural Chemistry Research Div.; Stevenson, M H [Dept. of Agriculture for Northern Ireland, Belfast (United Kingdom). Food and Agricultural Chemistry Research Div. Queen' s Univ., Belfast, Northern Ireland (United Kingdom)

    1991-01-01

    In these days, there is a growing interest in reliable methods for the identification of foods treated with ionising rays. The authors have chosen chicken and lobster as examples to demonstrate the usefulness of ESR spectroscopy in the detection of such irradiation treatments. Furthermore, it could be shown that even after some time had elapsed there still was a direct relation between ESR signals and the irradiation dose originally used, which fact appears to provide a basis for the development of quantitative methods for the detection of irradiation treatment at any later point of time. (orig.).

  15. Effects of alpha radiation on plutonium incorporated in dosimetric materials by ESR studies

    International Nuclear Information System (INIS)

    Bhide, M.K.; Kadam, R.M.; Mohapatra, Manoj; Godbole, S.V.

    2007-01-01

    The in situ alpha irradiation effects of some ESR dosimetric materials namely alanine, 2-methyl alanine and ammonium tartrate were studied by incorporating 1% plutonium by weight in them. The radical intensity was monitored as a function of alpha dose. It was found that in the dose region 1-35 kGy ammonium tartrate showed better signal intensity, linearity and dose response as compared to the other materials. This was attributed to the single radical produced in case of the tartrate giving a sharp spectrum and the fast relaxation times owing to less saturation of ESR signals. (author)

  16. X-band ESR study on evaluation of radicals induced in pasteurized pepper

    International Nuclear Information System (INIS)

    Matsuura, Masaaki; Ogawa, Satoko; Ukai, Mitsuko; Oowada, Shigeru

    2007-01-01

    The radical properties of pasteurized pepper were investigated by means of X-band ESR spectroscopy. Pasteurization process was done by irradiation or steam. There were three radicals in the specimens before and after pasteurization. Upon irradiation a new radical was found. ESR peak intensity of specimen before and after parturition with steam was almost same level. Peak intensity of radiated pepper showed almost 4 times as compare with that of non treated pepper. Radical activity of the specimens after pasteurization showed almost same value. We concluded that radicals were induced by irradiation. But the radical activity was not changed before and after pasteurization. (author)

  17. Combined ESR/U-series chronology of Acheulian hominid-bearing layers at Trinchera Galería site, Atapuerca, Spain.

    Science.gov (United States)

    Falguères, Christophe; Bahain, Jean-Jacques; Bischoff, James L; Pérez-González, Alfredo; Ortega, Ana Isabel; Ollé, Andreu; Quiles, Anita; Ghaleb, Bassam; Moreno, Davinia; Dolo, Jean-Michel; Shao, Qingfeng; Vallverdú, Josep; Carbonell, Eudald; Bermúdez de Castro, Jose María; Arsuaga, Juan Luis

    2013-08-01

    The Sierra de Atapuerca, northern Spain, is known from many prehistoric and palaeontological sites documenting human prehistory in Europe. Three major sites, Gran Dolina, Galería and Sima del Elefante, range in age from the oldest hominin of Western Europe dated to 1.1 to 1.3 Ma (millions of years ago) at Sima del Elefante to c.a. 0.2 Ma on the top of the Galería archaeological sequence. Recently, a chronology based on luminescence methods (Thermoluminescence [TL] and Infrared Stimulated Luminescence [IRSL]) applied to cave sediments was published for the Gran Dolina and Galería sites. The authors proposed for Galería an age of 450 ka (thousands of years ago) for the units lower GIII and GII, suggesting that the human occupation there is younger than the hominid remains of Sima de los Huesos (>530 ka) around 1 km away. In this paper, we present new results obtained by combined Electron Spin Resonance/Uranium-series (ESR/U-series) dating on 20 herbivorous teeth from different levels at the Galería site. They are in agreement with the TL results for the upper part of the stratigraphic sequence (GIV and GIIIb), in the range of between 200 and 250 ka. But for the GIIIa to GIIb levels, the TL ages become abruptly older by 200 ka while ESR ages remain relatively constant. Finally, the TL and ESR data agree in the lowest part of the section (GIIa); both fall in the range of around 350-450 ka. Our results suggest a different interpretation for the GII, GIII and GIV units of Galería and the upper part of Gran Dolina (TD10 and TD11) than obtained by TL. The ESR/U-series results are supported by a Bayesian analysis, which allows a better integration between stratigraphic information and radiometric data. Copyright © 2013 Elsevier Ltd. All rights reserved.

  18. Microstructure Characterization and Corrosion Resistance Behavior of New Cobalt-Free Maraging Steel Produced Through ESR Techniques

    Science.gov (United States)

    Seikh, Asiful H.; Halfa, Hossam; Baig, Muneer; Khan, Sohail M. A.

    2017-04-01

    In this study, two different grades (M23 and M29) of cobalt-free low nickel maraging steel have been produced through electroslag remelting (ESR) process. The corrosion resistance of these ESR steels was investigated in 1 M H2SO4 solution using linear potentiodynamic polarization (LPP) and electrochemical impedance spectroscopy (EIS) techniques. The experiments were performed for different immersion time and solution temperature. To evaluate the corrosion resistance of the ESR steels, some significant characterization parameters from LPP and EIS curves were analyzed and compared with that of conventional C250 maraging steel. Irrespective of measurement techniques used, the results show that the corrosion resistance of the ESR steels was higher than the C250 steel. The microstructure of ESR steels was composed of uniform and well-distributed martensite accompanied with little amount of retained austenite in comparison with C250 steel.

  19. LiSr4(BO3)3:Ce3+ phosphor as a new material for ESR dosimetry

    International Nuclear Information System (INIS)

    Jiang, L.H.; Zhang, Y.L.; Gong, X.M.; Pang, R.; Zhang, S.; Li, C.Y.; Su, Q.

    2014-01-01

    LiSr 4 (BO 3 ) 3 :0.01Ce 3+ phosphor was investigated to assess its potential as a material for measurements of radiotherapeutic doses with electron spin resonance (ESR). The ESR spectrum of the phosphor irradiated with 60 Co features five ESR signals. An isochronal annealing experiment has shown that the strongest of these signals is associated with the same trap center as the 473 K peak on the TL glow curve of this material. The dose–response is linear in the studied range from 0.89 to 90.30 Gy. Fading of the signal was also investigated. - Highlights: • LiSr 4 (BO 3 ) 3 :Ce 3+ phosphor can be used as an ESR dosimeter for radiation therapy. • The ESR signal originates from the same traps as the TL. • Dose–response is linear, and the fading is slow

  20. Determination of isodose curves in Radiotherapy using an Alanine/ESR dosemeter; Determinacion de curvas de isodosis en Radioterapia usando un dosimetro de Alanina/ESR

    Energy Technology Data Exchange (ETDEWEB)

    Chen, F.; Baffa, O.; Graeff, C.F.O. [Departamento de Fisica e Matematica. Universidade de Sao Paulo FFCLRP. 14040-901 Ribeirao Preto-SP (Brazil)

    1998-12-31

    It was studied the possible use of an Alanine/ESR dosemeter in the isodose curves mapping in normal treatments of Radiotherapy. It was manufactured a lot of 150 dosemeters with base in a mixture of D-L Alanine dust (80 %) and paraffin (20 %). Each dosemeter has 4.7 mm diameter and 12 mm length. A group of 100 dosemeters of the lot were arranged inside 50 holes of the slice 25 of the phantom Rando Man. The phantom irradiation was realized in two opposed projections (AP and PA) in Co-60 equipment. A group of 15 dosemeters was take of the same lot for obtaining the calibration curve in a 1-20 Gy range. After irradiation the signal of each dosemeter was measured in an ESR spectrometer operating in the X-band ({approx} 9.5 GHz) and the wideness of Alanine ESR spectra central line was correlated with the radiation dose. The wideness dose calibration curve resulted linear with a correlation coefficient 0.9996. The isodose curves obtained show a profile enough similar at comparing with the theoretical curves. (Author)

  1. Validity and predictive ability of the juvenile arthritis disease activity score based on CRP versus ESR in a Nordic population-based setting

    DEFF Research Database (Denmark)

    Nordal, E B; Zak, M; Aalto, K

    2012-01-01

    To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting.......To compare the juvenile arthritis disease activity score (JADAS) based on C reactive protein (CRP) (JADAS-CRP) with JADAS based on erythrocyte sedimentation rate (ESR) (JADAS-ESR) and to validate JADAS in a population-based setting....

  2. ESR Study Applied To Thermal Stability Of Radiation-Induced Species Of Solid Ketoprofen

    International Nuclear Information System (INIS)

    Maltar-Strmecki, N.; Katusin-Razem, B.; Razem, D.

    2015-01-01

    Ketoprofen [2-(3-benzoylphenyl) propionic acid] is a non-steroidal anti-inflammatory drug. It has been widely used in human and veterinary medicine. Radiation processing of drugs and its ingredients is recognized as a safe and effective method among the existing technologies for sterilization and protocols that can be found in ISO 11137-1. Radiosterilization of drugs or other medical products by a suitable dose of ionizing radiation conducted in an appropriate environment ensures sterile conditions by destroying or removing vegetative and sporulating microbes from the ingredients or environment. In earlier studies the effects of gamma radiation was evaluated by selected physico-chemical methods and the observations showed that solid ketoprofen is relatively stable toward ionizing irradiation and that radiosterilization might be a suitable method for the sterilization of solid ketoprofen. The studies reported in this work were undertaken to analyse thermal stability of free radicals by accelerated aging method with a view to the determination of shelf-life. The expiration date (shelf-life) of a product is based on evaluation of both, thermal stability of free radicals, as well as on the time evolution of stable radiolysis products. Namely, storage time is determined by the time required by any degradation product in the dosage form to achieve a sufficient level to represent a risk to the patient. This work shows that ESR spectroscopy provides means for determination of thermal stability of radicals induced by gamma-irradiation in solid drugs. Therefore, despite the complex mixture of individual free radicals induced by gamma-irradiation in solid ketoprofen, the overall lifetime of free radicals could be determined by using isothermal and isochronal annealing. This study shows that radicals induced by gamma-irradiation in solid ketoprofen are stable for at least about 6 months. (author).

  3. META-ANALYSIS OF GENOME-WIDE STUDIES IDENTIFIES WNT16 AND ESR1 SNPS ASSOCIATED WITH BONE MINERAL DENSITY IN PREMENOPAUSAL WOMEN

    Science.gov (United States)

    Koller, Daniel L.; Zheng, Hou-Feng; Karasik, David; Yerges-Armstrong, Laura; Liu, Ching-Ti; McGuigan, Fiona; Kemp, John P.; Giroux, Sylvie; Lai, Dongbing; Edenberg, Howard J.; Peacock, Munro; Czerwinski, Stefan A.; Choh, Audrey C.; McMahon, George; St Pourcain, Beate; Timpson, Nicholas J.; Lawlor, Debbie A; Evans, David M; Towne, Bradford; Blangero, John; Carless, Melanie A.; Kammerer, Candace; Goltzman, David; Kovacs, Christopher S.; Prior, Jerilynn C.; Spector, Tim D.; Rousseau, Francois; Tobias, Jon H.; Akesson, Kristina; Econs, Michael J.; Mitchell, Braxton D.; Richards, J. Brent; Kiel, Douglas P.; Foroud, Tatiana

    2013-01-01

    Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these results have identified numerous SNPs of modest effect at genome-wide significance levels in genes involved in both bone formation and resorption, as well as other pathways. We performed a meta-analysis restricted to premenopausal white women from four cohorts (n= 4,061 women, ages 20 to 45) to identify genes influencing peak bone mass at the lumbar spine and femoral neck. Following imputation, age- and weight-adjusted BMD values were tested for association with each SNP. Association of a SNP in the WNT16 gene (rs3801387; p=1.7 × 10−9) and multiple SNPs in the ESR1/C6orf97 (rs4870044; p=1.3 × 10−8) achieved genome-wide significance levels for lumbar spine BMD. These SNPs, along with others demonstrating suggestive evidence of association, were then tested for association in seven Replication cohorts that included premenopausal women of European, Hispanic-American, and African-American descent (combined n=5,597 for femoral neck; 4,744 for lumbar spine). When the data from the Discovery and Replication cohorts were analyzed jointly, the evidence was more significant (WNT16 joint p=1.3 × 10−11; ESR1/C6orf97 joint p= 1.4 × 10−10). Multiple independent association signals were observed with spine BMD at the ESR1 region after conditioning on the primary signal. Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97 (p< 1 × 10−5). Our results confirm that several of the genes contributing to BMD variation across a broad age range in both sexes have effects of similar magnitude on BMD of the spine in premenopausal women. These data support the hypothesis that variants in these genes of known skeletal function also affect BMD during the premenopausal period. PMID:23074152

  4. Recent progress in application of JAERI alanine/ESR dosimetry system

    International Nuclear Information System (INIS)

    Kojima, T.

    1995-01-01

    Feasibility studies of application of JAERI alanine/ESR dosimetry system were performed on radiotherapy level dosimetry, low dose-rate dosimetry for residual life estimation of cable insulators used in nuclear power facilities, and dose monitoring for electron processing. (author)

  5. Recognition of malignant processes with neural nets from ESR spectra of serum albumin

    Energy Technology Data Exchange (ETDEWEB)

    Seidel, P. [Inst. of Medical Physics and Biophysics, Univ. Leipzig (Germany); Gurachevsky, A.; Muravsky, V.; Schnurr, K.; Seibt, G. [Medinnovation GmbH, Wildau (Germany); Matthes, G. [Inst. of Transfusion Medicine, Univ. Hospital Leipzig (Germany)

    2005-07-01

    Cancer diseases are the focus of intense research due to their frequent occurrence. It is known from the literature that serum proteins are changed in the case of malignant processes. Changes of albumin conformation, transport efficiency, and binding characteristics can be determined by electron spin resonance spectroscopy (ESR). The present study analysed the binding/dissociation function of albumin with an ESR method using 16-doxyl stearate spin probe as reporter molecule and ethanol as modifier of hydrophobic interactions. Native and frozen plasma of healthy donors (608 samples), patients with malignant diseases (423 samples), and patients with benign conditions (221 samples) were analysed. The global specificity was 91% and the sensitivity 96%. In look-back samples of 27 donors, a malignant process could be detected up to 30 months before clinical diagnosis. To recognise different entities of malignant diseases from the ESR spectra, Artificial neural networks were implemented. For 48 female donors with breast cancer, the recognition specificity was 85%. Other carcinoma entities (22 colon, 18 prostate, 12 stomach) were recognised with specificities between 75% and 84%. Should these specificity values be reproduced in larger studies, the described method could be used as a new specific tumour marker for the early detection of malignant processes. Since transmission of cancer via blood transfusion cannot be excluded as yet, the described ESR method could also be used as a quality test for plasma products. (orig.)

  6. [Clinical relevance of ESR1 circulating mutations detection in hormone receptor positive metastatic breast cancer].

    Science.gov (United States)

    Clatot, Florian; Perdrix, Anne; Sefrioui, David; Sarafan-Vasseur, Nasrin; Di Fiore, Frédéric

    2018-01-01

    If hormone therapy is a key treatment for hormone receptor positive advanced breast cancers, secondary resistance occurs as a rule. Recently, acquired alterations of the ESR1 gene have been identified as a mechanism of resistance on aromatase inhibitor (AI) treatment. The selective pressure by AI exposure during the metastatic setting triggers the emergence of ESR1 activating mutations. In that context, the "liquid biopsy" concept has been used to detect this molecular resistance before progression. Thus, the ESR1 circulating mutation detection will soon be used in daily practice to help monitoring patients on AI treatment and provide an early change for specific therapies that still have to be determined in prospective clinical trials. This review will present the acquired ESR1 mutations, as well as the methods used for their detection in blood and the potential clinical impact of this approach for hormone receptor positive breast cancer management. Copyright © 2017 Société Française du Cancer. Published by Elsevier Masson SAS. All rights reserved.

  7. An ESR protocol based on relaxation phenomena of irradiated Japanese pepper

    Science.gov (United States)

    Ukai, Mitsuko; Nakamura, Hideo; Shimoyama, Yuhei

    2006-03-01

    We found various free radicals in a commercially available pepper in Japan before and after irradiation using electron spin resonance (ESR) spectroscopy. The typical ESR spectrum of the pepper consists of a sextet centered at g = 2.0, a singlet at the same g-value and a singlet at g = 4.0. Upon gamma ray irradiation, a new pair of signals appeared in the pepper. The progressive saturation behavior (PSB) at various microwave power levels indicated quite different relaxation behaviors of those radicals. Namely, the peak intensity of the organic free radical component decreases in a monotonic fashion, whereas the Mn 2+ and Fe 3+ ESR signals substantially keep constant. This reflects the evidence of three independent radicals in the pepper before irradiation. The PSB of the pair peaks as induced by irradiation possessed quite different PSB from that of the free radical located at g = 2.0. We proposed a new protocol for the ESR detection of irradiated foods by the PSB method at different microwave power levels. This would call for a major modification of the CEN protocol in European Union.

  8. IN VIVO EVIDENCE OF FREE RADICAL FORMATION AFTER ASBESTOS INSTILLATION: AN ESR SPIN TRAPPING INVESTIGATION

    Science.gov (United States)

    It has been postulated that the in vivo toxicity of asbestos results from its catalysis of free radical generation. We examined in vivo radical production using electron spin resonance (ESR) coupled with the spin trap alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (4-POBN); 180 d...

  9. ESR Spectra of Some Silicate Minerals: A Search For New Dosimetric Materials

    International Nuclear Information System (INIS)

    Abdel-Monem, A.A.; Abdel-Razek, Y.A.; Rasheed, G. M.; Hassan, G.M.; Eissa, H.M.; Morsy, M.

    2008-01-01

    Two silicate minerals talc (Mg 3 Si 4 O 1 0 (OH) 2 ) and zircon (ZrSiO 4 ) having different crystal lattice structures were subjected to ESR dosimetric studies. Zircon shows anisotropic ESR signals at g xx =2.0168, g yy =2.0076 and g zz =2.0033, which have been identified as a hole center associated with Y 3+ substituted at Zr 4+ sites. Other characteristic signals have been observed and identified. The ESR signal at g=2.0033 showed positive response to γ-irradiation at 110 Gy and is suitable to be used for dosimetry and dating of natural zircons. Talc a magnesium sheeted silicate exhibits ESR derivative spectrum characterized the presence of Fe 3+ at g=4.28 and the HF-sixtet Mn 2+ signals due to possible substitution of Fe 3+ and Mn 2+ in the Mg 2+ octahedral sites, respectively. The enhancement of the Mn 2+ sixtet by γ-irradiation increases the area occupied by the signals which makes it difficult to use for dosimetric applications

  10. ESR study of radiation damage in pyrimidines. Progress report, August 1, 1975--April 1, 1976

    International Nuclear Information System (INIS)

    Benson, B.W.

    1976-04-01

    The primary objective of this project is to develop general mechanisms for radiation damage to biomolecules using substituted pyrimidines as a model system. Results this year include a single crystal ESR study of 5-ethyl-5-isopropylbarbituric acid, development of the k-band microwave bridge, dose response measurements on methylated barbituric acid derivatives, and synthesis of several specifically deuterated uracil derivatives

  11. Consideration on detection of irradiated rainbow trout by ESR method and 2-alkylcyclobutanone analysis

    International Nuclear Information System (INIS)

    Tanabe, Hiroko; Goto, Michiko

    2002-01-01

    Relative ESR strength of rib, backbone and opercular bone from irradiated culture rainbow trout was direct proportional to dose between 0.56kGy and 5.7kGy. Relative ESR strength of rib was higher than that of backbone. Although only 5mg of otolith was obtained from one rainbow trout, bone density of otolith is so high that relative ESR strength of otolith showed about 20-fold higher value than that of rib. In GCMS-SIM analysis of RCB, radiolytic compounds of lipid of fish meat, the amount of both DCB and TCB formed, estimated from ion concentrations of m/z98, were direct proportional to dose between 1.1kGy and 11.1kGy. Neither DCB nor TCB was detected in unirradiated sample. The ratio of amount of DCB formed to amount of TCB formed was nearly 4.4, which is the ratio of palmitic acid content to stearic acid content in rainbow trout, denoted in Standard Tables of Food Composition in Japan; Lipid composition of Foods. Finally, we propose to use detection of radiolytic compound, RCB, and measurement of ESR of high-density bone together for reliable identification of irradiated fish. (author)

  12. Variability of electron spin resonance (ESR) signal of γ -irradiated starches

    International Nuclear Information System (INIS)

    Silva, Gilberto D.; Rodrigues Junior, Orlando; Mastro, Nelida L. del

    2017-01-01

    Food preservation is one of the practical applications of radiation processing of materials. Starch is an abundant and cheap nutritious biopolymer and also is the material for appropriate food systems and for technical industries. Starch granules are partially crystalline structures composed mainly of two types of starch: amylose, an essentially linear polymer, and amylopectin, with 3-44% of branch points. Electron spin resonance (ESR) spectroscopy is a very powerful and sensitive method for the characterization of the electronic structures of materials with unpaired electrons. The aim of the present work was to monitor the disappearance of the short life and long-life free radicals formed during γ-irradiation of 3 different starches. Corn, potato and fermented cassava starches were irradiated in a "6"0Co source Gammacell 220 with 20 kGy, dose rate around 1 kGy h"-"1. EPR spectra were obtained at room temperature using a Bruker EMX plus model, X band equipment. The main type of ESR signal from irradiated starch is a singlet with a g-value of about 2.0. The fading of ESR signals was followed for 350 hours, and presents differences among the different starch type reflecting differences in molecular arrangements of starch crystalline and amorphous fractions, although ESR spectra seemed to be common for all starches. (author)

  13. ESR and microbiological studies on gamma radiation processed dehydrated onion powder

    International Nuclear Information System (INIS)

    Khedkar, K.C.; Kumbhare, M.N.; Sharma, G.; Lavale, D.S.; Kadam, R.M.; Bhide, M.K.; Sastry, M.D.

    2001-01-01

    Paper describes the potential of ESR technique for detection of free radicals produced in the irradiated onion powder. Experiments were carried out to evaluate the effect of light, moisture and time on the stability of free radicals produced by gamma radiation. Some microbiological studies were also carried out on unprocessed and radiation-processed product. (author)

  14. ESR study on hydrogen-atom abstraction in cryogenic organic solids

    International Nuclear Information System (INIS)

    Ichikawa, Tsuneki

    1995-01-01

    The present paper summarizes our recent results on the hydrogen-atom abstraction from protiated alkane molecule by deuterium atoms in cryogenic deuterated organic solids, obtained by the X-band ESR and electron spin-echo measurements of the product alkyl radicals at cryogenic temperatures. (J.P.N.)

  15. Direct access to dithiobenzoate RAFT agent fragmentation rate coefficients by ESR spin-trapping.

    Science.gov (United States)

    Ranieri, Kayte; Delaittre, Guillaume; Barner-Kowollik, Christopher; Junkers, Thomas

    2014-12-01

    The β-scission rate coefficient of tert-butyl radicals fragmenting off the intermediate resulting from their addition to tert-butyl dithiobenzoate-a reversible addition-fragmentation chain transfer (RAFT) agent-is estimated via the recently introduced electron spin resonance (ESR)-trapping methodology as a function of temperature. The newly introduced ESR-trapping methodology is critically evaluated and found to be reliable. At 20 °C, a fragmentation rate coefficient of close to 0.042 s(-1) is observed, whereas the activation parameters for the fragmentation reaction-determined for the first time-read EA = 82 ± 13.3 kJ mol(-1) and A = (1.4 ± 0.25) × 10(13) s(-1) . The ESR spin-trapping methodology thus efficiently probes the stability of the RAFT adduct radical under conditions relevant for the pre-equilibrium of the RAFT process. It particularly indicates that stable RAFT adduct radicals are indeed formed in early stages of the RAFT poly-merization, at least when dithiobenzoates are employed as controlling agents as stipulated by the so-called slow fragmentation theory. By design of the methodology, the obtained fragmentation rate coefficients represent an upper limit. The ESR spin-trapping methodology is thus seen as a suitable tool for evaluating the fragmentation rate coefficients of a wide range of RAFT adduct radicals. © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  16. Alanine-ESR dosimeter: application for dosimetry in industrial electron beam accelerator

    International Nuclear Information System (INIS)

    Murali, S.; Venkataramani, R.; Pushparaja; Sarma, K.S.S.; Natarajan, V.; Sastry, M.D.

    2000-01-01

    The feasibility of DL-α-alanine, as ESR dosimeter in powder form, was examined under the conditions of pulse electron accelerator used as an industrial irradiator. The investigations were carried out to examine the following aspects: (i) Alanine-ESR dose response in irradiator characteristics viz. various beam energies, beam currents, product conveying speeds, (ii) linearity of dose response of irradiated alanine signal for suitable range, (iii) dose uniformity of the irradiated samples and (iv) depth dose measurements using alanine powder dosimeters sandwiched between polyethylene layers. Experiments were carried out by varying some of the irradiator parameters at mobile mode of the conveyor (product under movement) and also at stationary mode for different EB energies and pulse rates. For estimation of EB dose, signal intensities of gamma irradiated DL--alanine powder calibrated with Fricke dosimetry have been used. Feasibility of application of alanine ESR dosimeter for low dose measurement down to 350 Gy has been experimentally established. The present studies show that under variable operating conditions of irradiator, alanine ESR dosimetry is suitable for dosimetric applications from low dose (350 Gy) to high dose (53 kgy). (author)

  17. Alanine/ESR dosimetry system for routine use in radiation processing

    International Nuclear Information System (INIS)

    Kojima, T.; Haruyama, Y.; Tachibana, H.; Tanaka, R.; Okamoto, J.; Hara, H.; Kashiwazaki, S.

    1993-01-01

    A new alanine-polystyrene(PS) dosimeter prepared with simplified molding procedure and an automatic desk-top dose-reader of alanine dosimeter were developed for the purpose of routine use. Combination of these two allows us to apply a reliable alanine/ESR dosimetry system to routine dosimetric process control in industrial gamma radiation processing. (Author)

  18. ESR statement on radiation protection: globalisation, personalised medicine and safety (the GPS approach).

    Science.gov (United States)

    2013-12-01

    In keeping with its responsibility for the radiation protection of patients undergoing radiological examinations and procedures, as well as of staff who are getting exposed, and with due regard to requirements under European Directives, the European Society of Radiology (ESR) issues this statement. It provides a holistic approach, termed as Globalisation (indicating all the steps and involving all stakeholders), Personalisation (referring to patient-centric) and Safety-thus called GPS. While being conscious that there is need to increase access of radiological imaging, ESR is aware about the increasing inappropriate medical exposures to ionising radiation and wide variation in patient doses for the same examination. The ESR is convinced that the different components of radiation protection are often interrelated and cannot be considered in isolation The ESR's GPS approach stands for: Globalisation (indicating all the steps and involving all stakeholders), Personalisation (referring to patient-centric) and Safety-thus called GPS It can be anticipated that enhanced protection of patients in Europe will result through the GPS approach. Although the focus is on patient safety, staff safety issues will find a place wherever pertinent.

  19. Variability of electron spin resonance (ESR) signal of γ -irradiated starches

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Gilberto D.; Rodrigues Junior, Orlando; Mastro, Nelida L. del, E-mail: nlmastro@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2017-11-01

    Food preservation is one of the practical applications of radiation processing of materials. Starch is an abundant and cheap nutritious biopolymer and also is the material for appropriate food systems and for technical industries. Starch granules are partially crystalline structures composed mainly of two types of starch: amylose, an essentially linear polymer, and amylopectin, with 3-44% of branch points. Electron spin resonance (ESR) spectroscopy is a very powerful and sensitive method for the characterization of the electronic structures of materials with unpaired electrons. The aim of the present work was to monitor the disappearance of the short life and long-life free radicals formed during γ-irradiation of 3 different starches. Corn, potato and fermented cassava starches were irradiated in a {sup 60}Co source Gammacell 220 with 20 kGy, dose rate around 1 kGy h{sup -1}. EPR spectra were obtained at room temperature using a Bruker EMX plus model, X band equipment. The main type of ESR signal from irradiated starch is a singlet with a g-value of about 2.0. The fading of ESR signals was followed for 350 hours, and presents differences among the different starch type reflecting differences in molecular arrangements of starch crystalline and amorphous fractions, although ESR spectra seemed to be common for all starches. (author)

  20. Consideration on detection of irradiated rainbow trout by ESR method and 2-alkylcyclobutanone analysis

    International Nuclear Information System (INIS)

    Tanabe, H.; Goto, M.

    2002-01-01

    R elative ESR strength of rib, backbone and opercular bone from irradiated culture rainbow trout was direct proportional to dose between 0.56kGy and 5.7kGy. Relative ESR strength of rib was higher than that of backbone. Although only 5mg of otolith was obtained from one rainbow trout, bone density of otolith is so high that relative ESR strength of otolith showed about 20-fold higher value than that of rib. In GCMS-SIM analysis of RGB, radiolytic compounds of lipid of fish meat, the amount of both DCB and TCB formed, estimated from ion concentrations of m/z98, were direct proportional to dose between 1.1kGy and 11.1kGy. Neither DCB nor TCB was detected in unirradiated sample. The ratio of amount of DCB formed to amount of TCB formed was nearly 4.4, which is the ratio of palmitic acid content to stearic acid content in rainbow trout, denoted in Standard Tables of Food Composition in Japan; Lipid composition of Foods. Finally, we propose to use detection of radiolytic compound, RCB, and measurement of ESR of high-density bone together for reliable identification of irradiated fish

  1. Recognition of malignant processes with neural nets from ESR spectra of serum albumin

    International Nuclear Information System (INIS)

    Seidel, P.; Gurachevsky, A.; Muravsky, V.; Schnurr, K.; Seibt, G.; Matthes, G.

    2005-01-01

    Cancer diseases are the focus of intense research due to their frequent occurrence. It is known from the literature that serum proteins are changed in the case of malignant processes. Changes of albumin conformation, transport efficiency, and binding characteristics can be determined by electron spin resonance spectroscopy (ESR). The present study analysed the binding/dissociation function of albumin with an ESR method using 16-doxyl stearate spin probe as reporter molecule and ethanol as modifier of hydrophobic interactions. Native and frozen plasma of healthy donors (608 samples), patients with malignant diseases (423 samples), and patients with benign conditions (221 samples) were analysed. The global specificity was 91% and the sensitivity 96%. In look-back samples of 27 donors, a malignant process could be detected up to 30 months before clinical diagnosis. To recognise different entities of malignant diseases from the ESR spectra, Artificial neural networks were implemented. For 48 female donors with breast cancer, the recognition specificity was 85%. Other carcinoma entities (22 colon, 18 prostate, 12 stomach) were recognised with specificities between 75% and 84%. Should these specificity values be reproduced in larger studies, the described method could be used as a new specific tumour marker for the early detection of malignant processes. Since transmission of cancer via blood transfusion cannot be excluded as yet, the described ESR method could also be used as a quality test for plasma products. (orig.)

  2. Association Between the Estrogen Receptor Beta (ESR2) Rs1256120 Single Nucleotide Polymorphism and Adolescent Idiopathic Scoliosis: A Systematic Review and Meta-Analysis.

    Science.gov (United States)

    Zhao, Linlu; Roffey, Darren M; Chen, Suzan

    2017-06-01

    A systematic review and meta-analysis. The aim of this study was to assess and synthesize the current evidence on the association between the rs1256120 single nucleotide polymorphism (SNP) of the estrogen receptor beta gene (ESR2) and adolescent idiopathic scoliosis (AIS). Hormonal disturbance has been postulated as a potential etiological factor in the development of AIS. As estrogen receptors are important mediators of estrogen response, mutations in these genes, including rs1256120 of ESR2, have been chosen as susceptibility candidates for AIS predisposition. The association of rs1256120 with AIS has been investigated in several recent studies, but showed conflicting evidence. We conducted a systematic review to evaluate the strength of this body of evidence and quantitative synthesis to examine sources of heterogeneity. This study conformed to PRISMA guidelines. Using a sensitive search strategy, PubMed (MEDLINE), EMBASE, and HuGE Literature Finder databases were searched to identify relevant studies for inclusion in the systematic review and meta-analysis. Risk of bias was assessed using a modified Newcastle-Ottawa Scale. The inverse variance model was used to calculate summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) for the allelic (C vs. T) and genotypic comparisons. Planned subgroup and sensitivity analyses were performed. Three studies were included for systematic review and meta-analysis (n = 1264 AIS cases and n=1020 controls). A null relationship was found between rs1256120 and AIS (allelic OR = 1.20, 95% CI: 0.81-1.78, P = 0.36, I = 84.9%), with the first reported association likely to be false-positive and contributing substantially to heterogeneity. Findings from the systematic review and meta-analysis suggest that rs1256120 of ESR2 is unlikely to be a predisposing or disease-modifying genetic risk factor for AIS. 2.

  3. Expression of estrogen receptor α 36 (ESR36 in the hamster ovary throughout the estrous cycle: effects of gonadotropins.

    Directory of Open Access Journals (Sweden)

    Prabuddha Chakraborty

    Full Text Available Estradiol-17β (E plays an important role in ovarian follicular development. Evidence indicates that some of the effect of E is mediated by the transmembrane estrogen receptor. In this study, we examined the spatio-temporal expression of recently discovered ERα36 (ESR36, a splice variant of Esr1 and a receptor for non-genomic E signaling, in the hamster ovary during the estrous cycle and the role of gonadotropins and ovarian steroid hormones in ESR36 expression. ESR36 expression was high on estrus (D1:0900 h and declined precipitously by proestrus (D4:0900 h and remained low up to D4:1600 h. Immunofluorescence findings corroborated immunoblot findings and revealed that ESR36 was expressed only in the cell membrane of both follicular and non-follicular cells, except the oocytes. Ovarian ESR36 was capable of binding to the E-affinity matrix, and have different molecular weight than that of the ESR1 or GPER. Hypophysectomy (Hx resulted in a marked decline in ESR36 protein levels. FSH and LH, alone or combined, markedly upregulated ESR36 protein in Hx hamsters to the levels observed in D1 hamsters, but neither E nor P had any effect. Inhibition of the gonadotropin surge by phenobarbital treatment on D4:1100 h attenuated ESR36 expression in D1:0900 h ovaries, but the decline was restored by either FSH or LH replacement on D4 afternoon. This is the first report to show that ESR36, which is distinct from ESR1 or GPER is expressed in the plasma membrane of ovarian follicular and non-follicular cells, binds to E and its expression is regulated directly by the gonadotropins. In light of our previous findings, the results suggest that ovarian cells contain at least two distinct membrane estrogen receptors, such as GPER and ESR36, and strongly suggest for a non-genomic action of E regulating ovarian follicular functions.

  4. Population parameters for dose calculations: initial estimates of municipal, city and provincial age group population within 20, 50 and 80 kilometers of the PNPP-1

    International Nuclear Information System (INIS)

    Ramirez, R.A.

    1985-01-01

    The study attempts to determine the total population and population growth rates of four (4) age groups per municipality/city within twenty (20), fifty (50) and eighty (80) kilometers from the Philippine Nuclear Power Plant (PNPP-1). The population estimates were done at five (5) year intervals covering the next fifty years. The latest National Census and Statistics Office (NCSO) population projections at the provincial level under the assumption of moderate fertility and moderate mentality decline (series no. 2) were used to derive the estimates of the total population and population growth rates at the minicipality/city levels. The Bureau of Coastal and Geodetic Survey (BCGS) and the NCSO maps served as the bases for delineating the geographic and political boundaries covered by the study. The results will complement the findings of the PAEC project on agricultural parameters for radiation dose calculations and useful for related environmental studies. (author)

  5. Meta-analysis of genome-wide studies identifies WNT16 and ESR1 SNPs associated with bone mineral density in premenopausal women.

    Science.gov (United States)

    Koller, Daniel L; Zheng, Hou-Feng; Karasik, David; Yerges-Armstrong, Laura; Liu, Ching-Ti; McGuigan, Fiona; Kemp, John P; Giroux, Sylvie; Lai, Dongbing; Edenberg, Howard J; Peacock, Munro; Czerwinski, Stefan A; Choh, Audrey C; McMahon, George; St Pourcain, Beate; Timpson, Nicholas J; Lawlor, Debbie A; Evans, David M; Towne, Bradford; Blangero, John; Carless, Melanie A; Kammerer, Candace; Goltzman, David; Kovacs, Christopher S; Prior, Jerilynn C; Spector, Tim D; Rousseau, Francois; Tobias, Jon H; Akesson, Kristina; Econs, Michael J; Mitchell, Braxton D; Richards, J Brent; Kiel, Douglas P; Foroud, Tatiana

    2013-03-01

    Previous genome-wide association studies (GWAS) have identified common variants in genes associated with variation in bone mineral density (BMD), although most have been carried out in combined samples of older women and men. Meta-analyses of these results have identified numerous single-nucleotide polymorphisms (SNPs) of modest effect at genome-wide significance levels in genes involved in both bone formation and resorption, as well as other pathways. We performed a meta-analysis restricted to premenopausal white women from four cohorts (n = 4061 women, aged 20 to 45 years) to identify genes influencing peak bone mass at the lumbar spine and femoral neck. After imputation, age- and weight-adjusted bone-mineral density (BMD) values were tested for association with each SNP. Association of an SNP in the WNT16 gene (rs3801387; p = 1.7 × 10(-9) ) and multiple SNPs in the ESR1/C6orf97 region (rs4870044; p = 1.3 × 10(-8) ) achieved genome-wide significance levels for lumbar spine BMD. These SNPs, along with others demonstrating suggestive evidence of association, were then tested for association in seven replication cohorts that included premenopausal women of European, Hispanic-American, and African-American descent (combined n = 5597 for femoral neck; n = 4744 for lumbar spine). When the data from the discovery and replication cohorts were analyzed jointly, the evidence was more significant (WNT16 joint p = 1.3 × 10(-11) ; ESR1/C6orf97 joint p = 1.4 × 10(-10) ). Multiple independent association signals were observed with spine BMD at the ESR1 region after conditioning on the primary signal. Analyses of femoral neck BMD also supported association with SNPs in WNT16 and ESR1/C6orf97 (p women. These data support the hypothesis that variants in these genes of known skeletal function also affect BMD during the premenopausal period. Copyright © 2013 American Society for Bone and Mineral Research.

  6. Scalable control of mounting and attack by Esr1+ neurons in the ventromedial hypothalamus.

    Science.gov (United States)

    Lee, Hyosang; Kim, Dong-Wook; Remedios, Ryan; Anthony, Todd E; Chang, Angela; Madisen, Linda; Zeng, Hongkui; Anderson, David J

    2014-05-29

    Social behaviours, such as aggression or mating, proceed through a series of appetitive and consummatory phases that are associated with increasing levels of arousal. How such escalation is encoded in the brain, and linked to behavioural action selection, remains an unsolved problem in neuroscience. The ventrolateral subdivision of the murine ventromedial hypothalamus (VMHvl) contains neurons whose activity increases during male-male and male-female social encounters. Non-cell-type-specific optogenetic activation of this region elicited attack behaviour, but not mounting. We have identified a subset of VMHvl neurons marked by the oestrogen receptor 1 (Esr1), and investigated their role in male social behaviour. Optogenetic manipulations indicated that Esr1(+) (but not Esr1(-)) neurons are sufficient to initiate attack, and that their activity is continuously required during ongoing agonistic behaviour. Surprisingly, weaker optogenetic activation of these neurons promoted mounting behaviour, rather than attack, towards both males and females, as well as sniffing and close investigation. Increasing photostimulation intensity could promote a transition from close investigation and mounting to attack, within a single social encounter. Importantly, time-resolved optogenetic inhibition experiments revealed requirements for Esr1(+) neurons in both the appetitive (investigative) and the consummatory phases of social interactions. Combined optogenetic activation and calcium imaging experiments in vitro, as well as c-Fos analysis in vivo, indicated that increasing photostimulation intensity increases both the number of active neurons and the average level of activity per neuron. These data suggest that Esr1(+) neurons in VMHvl control the progression of a social encounter from its appetitive through its consummatory phases, in a scalable manner that reflects the number or type of active neurons in the population.

  7. Suitability of thermoluminescence, chemiluminescence, ESR and viscosity measurements as detection method for the irradiation of medicinal herbs; Eignung von Thermolumineszenz-, Chemilumineszenz-, ESR- und Viskositaetsmessungen zur Identifizierung strahlenbehandelter Arzneidrogen

    Energy Technology Data Exchange (ETDEWEB)

    Schuettler, C.; Gebhardt, G.; Stock, A.; Helle, N.; Boegl, K.W.

    1993-12-31

    Chemiluminescence, electron spin resonance, thermoluminescence and viscosity measurements have been investigated for their suitability as detection method for the irradiation of the medicinal herbs anise seeds (anisi fructus), valerian roots (valerianae radix), redberry leaves (uvae ursi folium), birch leaves (betulae folium), greek hay seeds (foenugraeci semen), cayenne pepper (capsici fructus acer), black-aldertee bark (frangulae cortex), fennel fruits (feoniculi fructus), rose hip shells (cynosbati fructus), coltsfoot (farfarae folium), acorus roots (calami rhizoma), chamomile flowers (matricariae flos), caraway (carvi fructus), lavender flowers (lavandulae flos), linseed (lini semen), lime tree flowers (tiliae flos), St. Mary`s thistle fruit (cardui mariae herba), lemon balm (melissae folium), java tea (orthosiphonis folium), peppermint (menthae piperitae folium), sage leaves (salviae folium), scouring rush (equiseti herba), senna leaves (sennae folium), plantain herbs (plantaginis lanceolata herba), thyme herbs (thymi herba), juniper berries (juniperi fructus), hawthorne herbs (crataegi folium), wheat starch (amylum tritici) and wormwood (absinthii herba). Depending on the herbs, the methods used were more or less suitable. Chemiluminescence measurements showed the smallest differences between untreated and irradiated samples whereas thermoluminescence measurements on isolated minerals from the vegetable drugs gave better results. In some herbs radiation-specific radicals could be identified by ESR spectroscopy. Viscosity measurement is suitable for some herbs as fast and inexpensive method for screening. (orig.) [Deutsch] Die Eignung von Chemilumineszenz-, ESR-, Thermolumineszenz- und Viskositaetsmessungen als Nachweismethode fuer die Behandlung von Arzneidrogen mit ionisierenden Strahlen wurde an Anis, Baldrianwurzel, Baerentraubenblaettern, Birkenblaettern, Bockshornsamen, Cayennepfeffer, Faulbaumrinde, Fenchel, Hagebuttenschalen, Huflattichblaettern

  8. The discrimination of some dermal dischromias using the ESR and NAA

    International Nuclear Information System (INIS)

    Georgescu, Rodica; Saidel, Alice; Cristodulo, Tania; Saidel, M.

    1997-01-01

    The information provided by the electron spin resonance (ESR) and neutron activation analysis (NAA) seem to complete each other most of time. ESR is applied in biology, due to its significant sensitivity and selectivity in the detection of paramagnetic states of free radicals implied in many physiological processes. Many enzymatic systems, photosynthesis intermediates or electrons transporting chain species are paramagnetic. On the other hand, free radicals are involved in the protection against ionic radiation, in immunity reactions and pathological processes including the oncogenesis. ESR spectroscopy informs about the quantity, interactions and dynamics of paramagnetic centres of the systems through spectral parameters as: the intensity, the g factor, the form and the width of line, hyperfine splitting, etc. NAA allows simultaneous determination of the concentration of essential microelements in tissues involved in the major biological pathways. In the present work we have tested the possibility of using the ESR and NAA investigations techniques combined with the factorial statistic analysis of the data, in the aim to discriminate some dermal dischromias of human skin. Having in view that the hyper- and hipochromia are due to an excess and deficit in melanin, respectively, we used ESR to observe the radical species from the skin samples. We studied the skin samples that represent different dischromias (malign melanoma, epithelioma, pigmentary nevus, vitiligo) in comparison with normal skin. On the same samples we have determined by NAA the concentrations of elements (Cu, Na, Mg, Mn, and Al) which could be involved in the mechanisms of producing and releasing the melanin. The signal ESR intensities and widths and the NAA elemental concentration values of the skin samples have been processed by a STATCF program to develop differences between dischromic and normal skin. The signification level of the differences observed among the sample groups has been evaluated

  9. Development of force-detected THz-ESR measurement system and its application to metal porphyrin complexes

    Science.gov (United States)

    Takahashi, Hideyuki; Okamoto, Tsubasa; Ohmichi, Eiji; Ohta, Hitoshi

    Electron spin resonance spectroscopy in the terahertz region (THz-ESR) is a promising technique to study biological materials such as metalloproteins because it directly probes the metal ion sites that play an important role in the emergence of functionality. By combining THz-ESR with force detection, the samples mass is reduced to the order of ng. This feature is of great advantage because the sample preparation process of biological materials is time-consuming. We developed a force-detected THz-ESR system utilizing optical interferometry for precise cantilever displacement measurement. In order to suppress the sensitivity fluctuation and instability of cantilever dynamics under high magnetic field, the tuning of interferometer is feedback-controlled during a measurement. By using this system, we successfully observed the ESR signal of hemin, which is a model substance of hemoglobin and myoglobin, in THz region.

  10. ESR study of advanced materials with new parameters frequency and pressure

    CERN Document Server

    Mizoguchi, K

    2000-01-01

    It is well known that electron spin resonance (ESR) is a useful technique to investigate the magnetic properties of electrons in condensed matter. The frequency, as an additional parameter to the temperature, gives us the possibility to study the anisotropic dynamics of charge carriers with spin, even in polycrystalline materials. Furthermore, the pressure provides us a way to discuss how interactions between the electrons and their environments are responsible for the novel physical properties in these advanced materials, such as ferromagnetisms, charge-density waves, superconductivity, and so on. Results obtained by using ESR with these parameters are overviewed. Studies as a function of the frequency are demonstrated, especially for the conductive polymers, polyacetylene, polyaniline, and polypyrrole with various dopants for which single crystals are not available yet. Alkali-electro-sodalite (AES), a kind of zeolite with a regular electron lattice known as an s-electron Mott insulator, and fullerene compo...

  11. Changes in molecular structure and properties of irradiated polymers of different compositions - ESR and NMR study

    International Nuclear Information System (INIS)

    Carswell-Pomerantz, T.; Babanalbandi, A.; Dong, L.; Hill, D.J.T.; Perera, M.C.S.; Pomery, P.J.; Saadat, G.; Whittaker, A.K.

    1999-01-01

    Investigations of molecular structural changes in polymers during exposure to high energy radiation is the long term interest of the Polymer Materials and Radiation Group at the University of Queensland. Recently, the group had looked at a range of polymers including natural and synthetic rubbers, methacrylates and polyesters. The objective of the work has been to investigate the relationships between polymer structure and sensitivity towards high energy radiation, including gamma radiation. This report will focus on the Electron Spin Resonance (ESR) and Nuclear Magnetic Resonance (NMR) studies of the effects of gamma irradiation on these polymers. Other methods such as Gas Chromatography (GC), Gel Permeation Chromatography (GPC), Fourier Transformed Infra Red (FTIR), Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA) and Dynamic Mechanical Analysis (DMA) have also been used as these methods combine with ESR and NMR, to provide a more complete picture of the mechanism of the structural changes. (author)

  12. Measurement of radical scavenging activity of irradiated Kampo extracts using ESR spin-trap method

    International Nuclear Information System (INIS)

    Ohta, Yui; Kawamura, Shoei; Ukai, Mitsuko; Nakamura, Hideo; Kikuchi, Masahiro; Kobayashi, Yasuhiko

    2014-01-01

    The radical scavenging activity (RSA) of 13 kinds of γ-ray irradiated Kampo extracts were studied by ESR spin-trap method. The RSA against alkoxy radical and hydroxyl radical were measured using new spin trapping reagent CYPMPO. The RSA against these two radicals were evaluated using GSH for alkoxy RSA and L-ascorbic acid for hydroxy RSA as a standard antioxidant reagent. We revealed that a few Kampo extracts showed high RSA against alkoxy radical and also hydroxy radical. This RSA of Kampo extracts was changed by γ-ray irradiation treatment. Using ESR spin-trap method, it is concluded that the effect of radiation treatment on RSA of Kampo extracts were able to detect. (author)

  13. The application of Alanine/ESR dosimetry in nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Hoon; Lee, Byung Il [Radiation Health Research Institute, Seoul (Korea, Republic of)

    2014-05-15

    Alanine/Electron spin resonance(ESR) has been proven very effective tool which dosimetric characteristics is better suitable than generally used personnel dosimeter for long term dose estimation. L-α-alanine has unusual stability of radiation induced radicals. The fading is known as about 1% a year by IAEA technical documentary. It also has linear signal response on gamma rays over the wide range of dose quantity. Alanine is a kind of unnecessary amino acid in 20 amino acids. Estimation of the accumulated gamma dose is important to predict the life expectancy of cables. However, exact estimation of gamma dose at containment building of NPP is very difficult, because the variability of estimation value is apparently depending on the each installation position in containment building. Especially, some installation positions near reactor change extremely. So, the data from ESR measurement should be checked to the details on referring installation map and pictures.

  14. Preparation of alanine/ESR dosimeter using different binder of polymer blend

    International Nuclear Information System (INIS)

    Razzak, M.T.; Sudiro, Sutjipto; Sudradjat, Adjat; Waskito, Ashar; Djamili, M.F.

    1995-01-01

    Different composition of polymer blend of low density polyethylene (PE) and polystyrene (PS) have been studied to be used as a binder for the preparation of Alanine/ESR dosimeter. The polymer binder and Alanine powder were blended in Laboplastomil Mixer at 140 o C and then it was pressed into a plastic film of 0.50 mm thickness. The film was cut into sample size of 250 mm x 2.5 mm and irradiated by gamma rays from a cobalt-60 source at different dose and dose rate. It was found that a blend of Alanine, PS and PE in composition of 60:30:10 is appropriate to prepare the Alanine/ESR dosimeter. (author)

  15. Uses of polymer-alanine film/ESR dosimeters in dosimetry of ionizing radiation

    International Nuclear Information System (INIS)

    Xie Liqing; Zhang Yinfeng; Dai Jinxian; Lu Ting; Chen Ruyi; Yang Hua

    1993-01-01

    Alanine ESR dosimetry is a reliable method, used in a various fields of ionizing radiation. The polymer-alanine film/ESR dosimeters of 0.3 -0.4 mm thickness were prepared and their dosimetric properties were studied for 60 Co γ photons and 3 - 5 MeV electrons in the dose range from 20 Gy to 100 kGy. The results show that under normal conditions the alanine calibration curves are linear in the dose range from 100 Gy to 10kGy. The dose profiles at the electron radiation field were measured with the film alanine dosimeters. The polymer-alanine film dosimeters were used for ion implantation of 400 keV ion implantor. Their dose response and energy dependence were investigated initially. (Author)

  16. ESR of Gd3+ in magnetically ordered Eu2CuO4

    International Nuclear Information System (INIS)

    Rettori, C.; Oseroff, S.B.; Rao, D.; Valdivia, J.A.; Barberis, G.E.; Martins, G.B.; Sarrao, J.; Fisk, Z.; Tovar, M.

    1996-01-01

    Electron spin resonance (ESR) experiments of Gd 3+ in the antiferromagnetic (AF) ordered phase (T N ) of Eu 2 CuO 4 can be interpreted in terms of four magnetically nonequivalent rare-earth sites with local internal fields H i =±310(30) Oe along the [100] and [010] directions. The internal field is well described by a dipolar magnetic field of a noncollinear AF array of 0.35(4) μ B per Cu moment aligned along the [100] and [010] directions. This is consistent with recent results of magnetic-field-dependent neutron-diffraction experiments. From the ESR and magnetic susceptibility data, the crystal field parameters for Gd 3+ and Eu 3+ in Eu 2 CuO 4 are determined. The exchange parameters between the rare earths are also estimated. copyright 1996 The American Physical Society

  17. Status report of the ESR/alanine project of the IAEA Dosimetry Laboratory

    International Nuclear Information System (INIS)

    Girzikowsky, R.

    1990-01-01

    The main tasks of the Dosimetry Laboratory of the IAEA are in the field of therapy-level dosimetry. Other dose ranges, i.e. protection-level standardization and calibration, are partly covered, too. On high-dose level the laboratory has been offering a Fricke-dosimetry service to Member States on request since 1965. In 1985 the Dosimetry Section has initiated an International Dose Assurance Service (IDAS). This service is an important part of the Agency's high-dose standardization programme and is based on Electron-Spin-Resonance (ESR) analysis of radiation-induced free radicals in alanine. This ESR/alanine dosimetry system was initially developed for high-dose application by GSF/Munich as the Agency's outside contractor. Although efforts were undertaken to equip the Agency Laboratory with an ESR analyzer since 1984, the purchase of an adequate unit was postponed until the end of 1988. From the date of establishment of the IDAS programme until today, the handling of all technical aspects, i.e. dosimeter production and evaluation was and is carried out by GSP/Munich under IAEA contract. As mentioned above, the IAEA Dosimetry Laboratory is in possession of its own ESR analyzer since December 1988. It was then installed in May 1989. Only one staff member of the laboratory was assigned to this project. He made himself acquainted with the analyzer, the measuring technique, and the application of alanine as dosimeter material. The ESR spectrometric analyzer is a CW ESR type ESP 300 manufactured by Bruker GmbH/FRG. It consists of a 9''/2,7 kW magnet, an X-band microwave bridge, a field regulator unit, a signal channel unit and a data system ESP 1620 based on the 68020 CPU. The probe material selected for measurement of concentration of radiation-induced free radicals is L-Alanine. This amino acid is a suitable material for transfer dosimeters due to its properties, i.e. wide sensitivity range (10 Gy to 100 kGy), energy independence for high-energy photons and electron

  18. ESR study of thermal demagnetization processes in ferromagnetic nanoparticles with Curie temperatures between 40 and 60 deg. C

    Energy Technology Data Exchange (ETDEWEB)

    Kuznetsov, Oleg A. [Institute of Biochemical Physics, Russian Academy of Sciences (RAS), Kosygin St. 4, Moscow 119991 (Russian Federation)]. E-mail: kuznetsov_oa@yahoo.com; Sorokina, Olga N. [Institute of Biochemical Physics, Russian Academy of Sciences (RAS), Kosygin St. 4, Moscow 119991 (Russian Federation); Leontiev, Vladimir G. [Institute of Metallurgy, Russian Academy of Sciences (RAS), Moscow 119991 (Russian Federation); Shlyakhtin, Oleg A. [Institute of Chemical Physics, Russian Academy of Sciences (RAS), Kosygin St. 4, Moscow 119991 (Russian Federation); Kovarski, Alexander L. [Institute of Biochemical Physics, Russian Academy of Sciences (RAS), Kosygin St. 4, Moscow 119991 (Russian Federation); Kuznetsov, Anatoly A. [Institute of Biochemical Physics, Russian Academy of Sciences (RAS), Kosygin St. 4, Moscow 119991 (Russian Federation)

    2007-04-15

    Thermal demagnetization in the vicinity of the Curie temperature of silver and sodium manganite nanoparticles, as well as copper-nickel and palladium-nickel alloy nanoparticles were studied by both static magnetic measurements and by electron spin resonance (ESR). ESR data indicate that some magnetic ordering remains even above the Curie temperature, determined by static magnetometry. Mechanisms of thermal demagnetization in alloy nanoparticles appear to be different from that in manganites.

  19. ESR study of thermal demagnetization processes in ferromagnetic nanoparticles with Curie temperatures between 40 and 60 deg. C

    International Nuclear Information System (INIS)

    Kuznetsov, Oleg A.; Sorokina, Olga N.; Leontiev, Vladimir G.; Shlyakhtin, Oleg A.; Kovarski, Alexander L.; Kuznetsov, Anatoly A.

    2007-01-01

    Thermal demagnetization in the vicinity of the Curie temperature of silver and sodium manganite nanoparticles, as well as copper-nickel and palladium-nickel alloy nanoparticles were studied by both static magnetic measurements and by electron spin resonance (ESR). ESR data indicate that some magnetic ordering remains even above the Curie temperature, determined by static magnetometry. Mechanisms of thermal demagnetization in alloy nanoparticles appear to be different from that in manganites

  20. Morphological Analysis of the Axonal Projections of EGFP-Labeled Esr1-Expressing Neurons in Transgenic Female Medaka.

    Science.gov (United States)

    Zempo, Buntaro; Karigo, Tomomi; Kanda, Shinji; Akazome, Yasuhisa; Oka, Yoshitaka

    2018-02-01

    Some hypothalamic neurons expressing estrogen receptor α (Esr1) are thought to transmit a gonadal estrogen feedback signal to gonadotropin-releasing hormone 1 (GnRH1) neurons, which is the final common pathway for feedback regulation of reproductive functions. Moreover, estrogen-sensitive neurons are suggested to control sexual behaviors in coordination with reproduction. In mammals, hypothalamic estrogen-sensitive neurons release the peptide kisspeptin and regulate GnRH1 neurons. However, a growing body of evidence in nonmammalian species casts doubt on the regulation of GnRH1 neurons by kisspeptin neurons. As a step toward understanding how estrogen regulates neuronal circuits for reproduction and sex behavior in vertebrates in general, we generated a transgenic (Tg) medaka that expresses enhanced green fluorescent protein (EGFP) specifically in esr1-expressing neurons (esr1 neurons) and analyzed their axonal projections. We found that esr1 neurons in the preoptic area (POA) project to the gnrh1 neurons. We also demonstrated by transcriptome and histological analyses that these esr1 neurons are glutamatergic or γ-aminobutyric acidergic (GABAergic) but not kisspeptinergic. We therefore suggest that glutamatergic and GABAergic esr1 neurons in the POA regulate gnrh1 neurons. This hypothesis is consistent with previous studies in mice that found that glutamatergic and GABAergic transmission is critical for estrogen-dependent changes in GnRH1 neuron firing. Thus, we propose that this neuronal circuit may provide an evolutionarily conserved mechanism for regulation of reproduction. In addition, we showed that telencephalic esr1 neurons project to medulla, which may control sexual behavior. Moreover, we found that some POA-esr1 neurons coexpress progesterone receptors. These neurons may form the neuronal circuits that regulate reproduction and sex behavior in response to the serum estrogen/progesterone. Copyright © 2018 Endocrine Society.

  1. Effects of gamma-irradiation on the erythrocyte membrane: ESR, NMR and biochemical studies

    International Nuclear Information System (INIS)

    Cantafora, A.; Ceccarini, M.; Guidoni, L.; Ianzini, F.; Minetti, M.; Viti, V.

    1987-01-01

    The effects of gamma-irradiation on resealed erythrocyte ghosts have been examined with different techniques. Phospholipid analysis reveals peroxidative damage on the polyunsaturated chains of phosphatidylethanolamine. Gel electrophoresis and ESR measurements indicate modifications of the cytoskeletal proteins. 31 P nuclear magnetic resonance data show bilayer modifications that can be interpreted as changes in lipid-protein interactions. The overall picture from the present results favours interaction between lipids and proteins in the inner monolayer of the membrane. (author)

  2. Binding of Mn(II) ions to lecithin bilayers as determined by ESR and NMR investigations

    International Nuclear Information System (INIS)

    Sabatini, G.; Tiezzi, E.; Valensin, G.

    1983-01-01

    The Mn(II)-lecithin system was investigated by means of paramagnetic relaxation studies. Unsonicated and sonicated aqueous dispersions were considered at various temperatures and pH values. Information was derived from both the frequency dependence of the ESR line shape and the paramagnetic contributions to the water proton relaxation rates. A dynamic equilibrium was suggested, by taking into account the role of the through-water cation binding in the metal-lipid interaction

  3. Radiation damage in bioapatites: the ESR spectrum of irradiated dental enamel revisited

    International Nuclear Information System (INIS)

    Rossi, A.M.; Poupeau, G.

    1990-01-01

    We have studied the ESR spectrum of enamel from fossil vertebrate teeth perpendicular = 2.0026 and g longitudinal = 1.9975; and species B, having an orthorhombic symmetry with g 1 = 2.0032, g 2 = 2.0018 and g 3 = 1.9975. Center A is probably located at an OH - site of the hydroxyapatite lattice. Centre B could be a distorted centre A. (author)

  4. QED in highly-charged high Z ions - experiments at the storage ring ESR

    International Nuclear Information System (INIS)

    Mokler, P.H.

    1996-01-01

    A survey on the fundamental structure aspects of very heavy few -electron ions, in particular H-like systems, is presented. Special emphasis is given to contribution from quantum-electro-dynamics at strong central potentials. The technical possibilities to produce highly-charged heavy ions are reviewed and the ground-state Lamb-shift experiments performed at the heavy ion storage ring ESR are summarized. A short outlook on further developments in this field is added. (author). 23 refs, 9 figs

  5. Pulsed ESR measurements of oxygen deficient type centers in various quartz

    International Nuclear Information System (INIS)

    Yamanaka, C.; Kohno, H.; Ikeya, M.

    1996-01-01

    Phase-memory times T M for E'-centers in various quartz samples were measured by pulse-ESR. Manually ground quartz followed by γ-irradiation, α-irradiated quartz and that from a natural uranium deposit showed T M M of 15-18μs. Natural SiO 2 with dense spins, (∼ 3.96 Ga) and sandstone from an impact crater were also examined. (author)

  6. Low cost ESR based X-ray beamline for lithography experimentation

    Energy Technology Data Exchange (ETDEWEB)

    Kovacs, S.; Doumas, A.; Truncale, M. (Grumman Corp., Bethpage, NY (United States). Space and Electronics Div.)

    1992-08-01

    Any application of the electron storage ring (ESR) based X-ray lithography technology requires an X-ray radiation transport system to transfer the synchrotron radiation into a spectrum defined by the lithography process requirements. Structure of this transport system (i.e. the beamline) depends on the nature of the application. In this paper a beamline conceptual design will be discussed. The beamline is intended for the developmment of X-ray lithography technology. (orig.).

  7. EsrE-A yigP Locus-Encoded Transcript-Is a 3′ UTR sRNA Involved in the Respiratory Chain of E. coli

    Directory of Open Access Journals (Sweden)

    Hui Xia

    2017-08-01

    Full Text Available The yigP locus is widely conserved among γ-proteobacteria. Mutation of the yigP locus impacts aerobic growth of Gram-negative bacteria. However, the underlying mechanism of how the yigP locus influences aerobic growth remains largely unknown. Here, we demonstrated that the yigP locus in Escherichia coli encodes two transcripts; the mRNA of ubiquinone biosynthesis protein, UbiJ, and the 3′ untranslated region small regulatory RNA (sRNA, EsrE. EsrE is an independent transcript that is transcribed using an internal promoter of the yigP locus. Surprisingly, we found that both the EsrE sRNA and UbiJ protein were required for Q8 biosynthesis, and were sufficient to rescue the growth defect ascribed to deletion of the yigP locus. Moreover, our data showed that EsrE targeted multiple mRNAs involved in several cellular processes including murein biosynthesis and the tricarboxylic acid cycle. Among these targets, sdhD mRNA that encodes one subunit of succinate dehydrogenase (SDH, was significantly activated. Our findings provided an insight into the important function of EsrE in bacterial adaptation to various environments, as well as coordinating different aspects of bacterial physiology.

  8. Multiple and Periodic Measurement of RBC Aggregation and ESR in Parallel Microfluidic Channels under On-Off Blood Flow Control

    Directory of Open Access Journals (Sweden)

    Yang Jun Kang

    2018-06-01

    Full Text Available Red blood cell (RBC aggregation causes to alter hemodynamic behaviors at low flow-rate regions of post-capillary venules. Additionally, it is significantly elevated in inflammatory or pathophysiological conditions. In this study, multiple and periodic measurements of RBC aggregation and erythrocyte sedimentation rate (ESR are suggested by sucking blood from a pipette tip into parallel microfluidic channels, and quantifying image intensity, especially through single experiment. Here, a microfluidic device was prepared from a master mold using the xurography technique rather than micro-electro-mechanical-system fabrication techniques. In order to consider variations of RBC aggregation in microfluidic channels due to continuous ESR in the conical pipette tip, two indices (aggregation index (AI and erythrocyte-sedimentation-rate aggregation index (EAI are evaluated by using temporal variations of microscopic, image-based intensity. The proposed method is employed to evaluate the effect of hematocrit and dextran solution on RBC aggregation under continuous ESR in the conical pipette tip. As a result, EAI displays a significantly linear relationship with modified conventional ESR measurement obtained by quantifying time constants. In addition, EAI varies linearly within a specific concentration of dextran solution. In conclusion, the proposed method is able to measure RBC aggregation under continuous ESR in the conical pipette tip. Furthermore, the method provides multiple data of RBC aggregation and ESR through a single experiment. A future study will involve employing the proposed method to evaluate biophysical properties of blood samples collected from cardiovascular diseases.

  9. Sterilization of proteinaceous food additives by irradiation. Temperature dependent changes in intensity of ESR signals generated by electron beam irradiation

    International Nuclear Information System (INIS)

    Sakaue, Kazushi; Murata, Yoshiyuki; Higashimura, Yutaka; Hayashi, Toru; Todoriki, Setsuko; Tada, Mikiro

    1999-01-01

    Thaumatin, egg white and soybean protein were selected as samples of proteinous food additives, and changes in the intensity of signals appearing in them after they had been irradiated with electron beams were measured by ESR. It was found by such measurement that the positions of signals of thaumatin and soy proteins are nearly the same. Changes in the intensity of radicals in thaumatin calculated on the basis of the coefficients of the respective approximations obtained by using thaumatin which had been irradiated and then stored at 4degC, 25degC, 37degC and 60degC showed that there is a temperature range to determine the remaining of such radicals (inner: 19.7degC, outer: 15.23degC) and that such radicals tend to decrease straight line-wise. It was confirmed that the intensity of signals in the protein powder such thaumatin and soy protein would not be affected at the storage condition below 15degC. (author)

  10. Sterilization of proteinaceous food additives by irradiation. Temperature dependent changes in intensity of ESR signals generated by electron beam irradiation

    Energy Technology Data Exchange (ETDEWEB)

    Sakaue, Kazushi; Murata, Yoshiyuki [Graduate School of Natural Science and Technology, Okayama Univ., Okayama (Japan); Higashimura, Yutaka [San-Ei Gen F.F.I., Inc., Osaka (Japan); Hayashi, Toru; Todoriki, Setsuko [National Food Research Institute, Ministry of Agriculture, Tsukuba, Ibaraki (Japan); Tada, Mikiro [Okayama Univ. (Japan). Faculty of Agriculture

    1999-09-01

    Thaumatin, egg white and soybean protein were selected as samples of proteinous food additives, and changes in the intensity of signals appearing in them after they had been irradiated with electron beams were measured by ESR. It was found by such measurement that the positions of signals of thaumatin and soy proteins are nearly the same. Changes in the intensity of radicals in thaumatin calculated on the basis of the coefficients of the respective approximations obtained by using thaumatin which had been irradiated and then stored at 4degC, 25degC, 37degC and 60degC showed that there is a temperature range to determine the remaining of such radicals (inner: 19.7degC, outer: 15.23degC) and that such radicals tend to decrease straight line-wise. It was confirmed that the intensity of signals in the protein powder such thaumatin and soy protein would not be affected at the storage condition below 15degC. (author)

  11. Detection of electron beam irradiated crude drugs by electron spin resonance (ESR)

    International Nuclear Information System (INIS)

    Yamaoki, Rumi; Kimura, Shojiro; Aoki, Kenji; Nishimoto, Susumu

    2007-01-01

    Perillae Herba, Sennae Folium, Cinnamomi Cortex, Phellodendri Cortex, Ginseng Radix, Glycyrrhizae Radix, Paeoniae Radix, and Zingiberis Rhizoma were irradiated with electron beam (5 MeV) and organic radicals were detected by ESR measurement, before and after irradiation (10 kGy). A single line spectrum was detected at around g=2.005 in non-irradiated crude drugs, and radical concentrations were high in the leaf varieties of crude drugs. After irradiation, the signal intensity around g=2.005 increased, and a new subsignal was detected as a 3 mT shoulder of this signal. Broad, asymmetrically divided signals were also detected in irradiated root varieties of crude drugs. The free radical localized on the organic components of irradiated crude drugs tended to decrease with the water content. After irradiation, signal intensity reduced and reached a steady state after about 1 to 2 months. However, specificity of the ESR signal shape appearing after irradiation continued to be detectable for 6 months in leaf varieties and for a year in bark and root varieties of crude drugs. Consequently, it was concluded that ESR could be applied as an initial screening procedure to detect irradiated crude drugs. (author)

  12. Radiation processes in organic halides (Cl, Br, I) studied by ESR spectroscopy

    International Nuclear Information System (INIS)

    Symons, M.C.R.

    1980-01-01

    Electron-loss from alkyl halides (Cl, Br, I) gives Rhal. + which may dimerise to give (Rhal-halR) + σ* radicals with characteristic ESR spectra, or may lose H + to give α-halo radicals (R 2 Chal) also with well characterised ESR spectra. Electron-capture gives dissociation, but there may be weak residual charge-transfer interaction between R. and hal - which gives rise to well defined hyperfine coupling from the halide nuclei. Loss of β-hydrogen gives β-halo radicals, R 2 C-CH 2 hal (Cl,Br) whose conformation, established by ESR spectroscopy, is such that the halogen atom lies out of the radical plane so that overlap between the half-filled 2p(π) orbital and the C-hal (σ) orbital is maximised. Electron addition to α-halocarboxylates and related compounds probably gives β-halo radical anions, (R 2 C[hal]CO 2 H) - with a similar preferred conformation. Alternative structures are considered for these species. (author)

  13. Determination of isodose curves in Radiotherapy using an Alanine/ESR dosemeter

    International Nuclear Information System (INIS)

    Chen, F.; Baffa, O.; Graeff, C.F.O.

    1998-01-01

    It was studied the possible use of an Alanine/ESR dosemeter in the isodose curves mapping in normal treatments of Radiotherapy. It was manufactured a lot of 150 dosemeters with base in a mixture of D-L Alanine dust (80 %) and paraffin (20 %). Each dosemeter has 4.7 mm diameter and 12 mm length. A group of 100 dosemeters of the lot were arranged inside 50 holes of the slice 25 of the phantom Rando Man. The phantom irradiation was realized in two opposed projections (AP and PA) in Co-60 equipment. A group of 15 dosemeters was take of the same lot for obtaining the calibration curve in a 1-20 Gy range. After irradiation the signal of each dosemeter was measured in an ESR spectrometer operating in the X-band (∼ 9.5 GHz) and the wideness of Alanine ESR spectra central line was correlated with the radiation dose. The wideness dose calibration curve resulted linear with a correlation coefficient 0.9996. The isodose curves obtained show a profile enough similar at comparing with the theoretical curves. (Author)

  14. ESR modes in a Strong-Leg Ladder in the Tomonaga-Luttinger Liquid Phase

    Science.gov (United States)

    Zvyagin, S.; Ozerov, M.; Maksymenko, M.; Wosnitza, J.; Honecker, A.; Landee, C. P.; Turnbull, M.; Furuya, S. C.; Giamarchi, T.

    Magnetic excitations in the strong-leg quantum spin ladder compound (C7H10N)2CuBr4 (known as DIMPY) in the field-induced Tomonaga-Luttinger spin liquid phase are studied by means of high-field electron spin resonance (ESR) spectroscopy. The presence of a gapped ESR mode with unusual non-linear frequency-field dependence is revealed experimentally. Using a combination of analytic and exact diagonalization methods, we compute the dynamical structure factor and identify this mode with longitudinal excitations in the antisymmetric channel. We argue that these excitations constitute a fingerprint of the spin dynamics in a strong-leg spin-1/2 Heisenberg antiferromagnetic ladder and owe its ESR observability to the uniform Dzyaloshinskii-Moriya interaction. This work was partially supported by the DFG and Helmholtz Gemeinschaft (Germany), Swiss SNF under Division II, and ERC synergy UQUAM project. We acknowledge the support of the HLD at HZDR, member of the European Magnetic Field Laboratory (EMFL).

  15. ESR (Electronic Spin Resonance Spectroscopy) study of irradiated paper for biomedical material wrapping

    International Nuclear Information System (INIS)

    Huarte, Monica; Rubin de Celis, Emilio; Kairiyama, Eulogia; Zapata, Miguel; Santoro, Natalia; Magnavacca, Cecilia

    2009-01-01

    Ionising radiation treatments are used for sterilization, microbiological decontamination, disinfection, insect disinfestation and food preservation. This ionising radiation generates free radicals (FR) in matter, which can be detected by Electronic Spin Resonance Spectroscopy (ESR). For this work it had analysed different kind of irradiated package papers of syringes, surgical gloves and dressings by ESR. These were irradiated with doses between 20 and 35 kGy of gamma radiation (Cobalt 60). The processed samples were measured in a Bruker ECS 106 spectrometer. The obtained results were: 1-) The irritated samples showed a central peak and two satellites induced by the applied radiation; 2-) The non-irradiated samples did not show the characteristic satellite peaks of the irritated ones; 3-) A linear relationship between the signal heights per unit mass and the applied doses was found; and 4-) The signals were highly stable, with half-time values between 240 and 370 days for 20 and 30 kGy, permitting more than one year of monitoring proceedings. In conclusion, the ESR allows the detection, quantification and time monitoring processes of this kind of irradiated materials. (author) [es

  16. On the connection of the ESR characteristics of zircons with the degree of their defectiveness

    International Nuclear Information System (INIS)

    Matyash, I.V.; Brik, A.E.; Derski, L.S.; Larikov, A.L.; Ponomarenko, A.N.

    1989-01-01

    The dynamic characteristics of the electron-hole centres (EHC) in zircons with various degree of defectiveness have been studied. Crystalline and amorphous regions are typical of different sets of EHC, having essentially different relaxation characteristics. Lack of cross-relaxation between these centres shows that they are localized in different parts of the crystal. The influence of autoirradiation and of corresponding defectiveness of the matrix upon the intensity of the EHC signals (V i ) has been studied. In the specimens of high crystallinity V i increases as the content of radioactive elements and defectiveness increases. In the essentially metamict specimens the situation reverses. Interpretation of this effect is given considering the dose dependence of the ESR signals and the ratio of the crystal and metamict volumes in the studied object. The transformations of the EHC set is traced along the amorphization of the zircon matrix due to the autoirradiation. ESR signals corresponding to different phases in zircon have been recorded. The correlation of the zircon grain size and the static magnetic susceptibility with V i have been studied. In the specimens of high crystallinity such correlation is absent and in metamict specimens the intensities V i decrease as the grain sizes decrease. The interpretation of this fact is proposed. It has been shown that the ESR studies reflect the processes of income and migration of the impurity elements in zircons and the ways of the zircon crystal matrix decay in a geological time scale. The factors controlling such a decay have been found. (author)

  17. Detection of irradiated strawberries by identifying ESR peak of irradiated cellulose component

    International Nuclear Information System (INIS)

    Goto, Michiko; Tanabe, Hiroko

    2002-01-01

    The method of detecting low-dose irradiated strawberries by identifying ESR peak of irradiated cellulose component was studied. Ratio of peak height (S) of high magnetic field cellulose component, and noise width (N) of either irradiated or unirradiated seeds of strawberries were compared. In this study, sample was identified to be irradiated when S/N ratio of ESR spectrum of 4 min. sweep time was above 0.7. In the case of S/N ratio below 0.7, when the S/N ratio of integrated ESR spectrum, obtained from measuring 10 times with 1 min. sweep time was above 1.0, the sample was identified to be irradiated. The result suggests that S/N ratio is a good marker to detect the irradiation. The strawberries irradiated above 0.5kGy was able to be detected after 3 days storage at room temperature, after 21 days refrigeration and after 60 days freezing, respectively. (author)

  18. In vivo dose evaluation during gynaecological radiotherapy using L-alanine/ESR dosimetry

    International Nuclear Information System (INIS)

    Burg Rech, Amanda; Baffa, Oswaldo; Barbi, Gustavo Lazzaro; Almeida Ventura, Luiz Henrique; Silva Guimaraes, Flavio; Oliveira, Harley Francisco

    2014-01-01

    The dose delivered by in vivo 3-D external beam radiation therapy (EBRT) was verified with L-alanine/electron spin resonance (ESR) dosimetry for patients diagnosed with gynaecological cancer. Measurements were performed with an X-band ESR spectrometer. Dosemeters were positioned inside the vaginal cavity with the assistance of an apparatus specially designed for this study. Previous phantom studies were performed using the same conditions as in the in vivo treatment. Four patients participated in this study during 20-irradiation sessions, giving 220 dosemeters to be analysed. The doses were determined with the treatment planning system, providing dose confirmation. The phantom study resulted in a deviation between -2.5 and 2.1 %, and for the in vivo study a deviation between -9.2 and 14.2 % was observed. In all cases, the use of alanine with ESR was effective for dose assessment, yielding results consistent with the values set forth in the International Commission on Radiation Units and Measurements (ICRU) reports. (authors)

  19. ESR Study of the polyvinyl alcohol gamma-ray induced free-radicals

    International Nuclear Information System (INIS)

    Rosas S, E.

    1994-01-01

    This work reports the findings of the molecular weight effect on the electron spin resonance saturation curve of the gamma-ray irradiated polyvinyl alcohol, G-RIPVA. It has been noted that Pva of a lower molecular weight, between 13,000-23,000, show some noticeable differences in the electron spin resonance, ESR, response as a function of the gamma-ray dose in the 1-100 k Gy range than the one reported in the literature with molecular weight of 108,000. Results show a linear response in the log-log plot of the dose vs ESR signal intensity for samples based on G-RIPVA of the lower molecular weight as contrasted with the non-linear ESR response of G-RIPVA of higher molecular weight in the above named dose range. Such a result has been assumed to arise from the shorter molecular chains for the case of the lower molecular weight samples making this to increase the production of Pva free radicals with respect to the absorbed studied doses. Also, a discussion on the nature and stability of the Pva free radicals will be given. (Author)

  20. Intensity limitations of cooled heavy ion beams in the ESR

    International Nuclear Information System (INIS)

    Hofmann, I.; Meyer-Pruessner, R.

    1985-06-01

    We consider the possibility of achieving maximum intensity and phase space density of heavy ions cooled by electrons in the Experimental Storage Ring to be built at GSI. Intrabeam scattering and the longitudinal microwave instability are found to be important limiting effects particularly at low energies. They are evaluated in diagrams, which can serve as a preliminary orientation for the expected performance of experiments. Examples have been calculated for U 92+ at 50 and 500 MeV/u; in the latter case we find that 9 ions at Δp/p=2x10 -4 and epsilon=0.2π mm mrad are on the safe side for an assumed cooling time of 100 msec. We have also analyzed I 20+ as a candidate for generating high energy density in matter. (orig.)

  1. Simple method for quantification of gadolinium magnetic resonance imaging contrast agents using ESR spectroscopy.

    Science.gov (United States)

    Takeshita, Keizo; Kinoshita, Shota; Okazaki, Shoko

    2012-01-01

    To develop an estimation method of gadolinium magnetic resonance imaging (MRI) contrast agents, the effect of concentration of Gd compounds on the ESR spectrum of nitroxyl radical was examined. A solution of either 4-oxo-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPONE) or 4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl (TEMPOL) was mixed with a solution of Gd compound and the ESR spectrum was recorded. Increased concentration of gadolinium-diethylenetriamine pentaacetic acid chelate (Gd-DTPA), an MRI contrast agent, increased the peak-to-peak line widths of ESR spectra of the nitroxyl radicals, in accordance with a decrease of their signal heights. A linear relationship was observed between concentration of Gd-DTPA and line width of ESR signal, up to approximately 50 mmol/L Gd-DTPA, with a high correlation coefficient. Response of TEMPONE was 1.4-times higher than that of TEMPOL as evaluated from the slopes of the lines. The response was slightly different among Gd compounds; the slopes of calibration curves for acua[N,N-bis[2-[(carboxymethyl)[(methylcarbamoyl)methyl]amino]ethyl]glycinato(3-)]gadolinium hydrate (Gd-DTPA-BMA) (6.22 μT·L/mmol) and gadolinium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid chelate (Gd-DOTA) (6.62 μT·L/mmol) were steeper than the slope for Gd-DTPA (5.45 μT·L/mmol), whereas the slope for gadolinium chloride (4.94 μT·L/mmol) was less steep than that for Gd-DTPA. This method is simple to apply. The results indicate that this method is useful for rough estimation of the concentration of Gd contrast agents if calibration is carried out with each standard compound. It was also found that the plot of the reciprocal square root of signal height against concentrations of contrast agents could be useful for the estimation if a constant volume of sample solution is taken and measured at the same position in the ESR cavity every time.

  2. Datación por ESR del yacimiento arqueológico del Pleistoceno inferior de Vallparadís (Terrassa, Cataluña, España

    Directory of Open Access Journals (Sweden)

    García, Joan

    2011-06-01

    Full Text Available Excavated between 2005 and 2007, the site of Vallparadís (Terrassa, Spain has given an abundant and diversified fauna associated with a rich Mode 1 industry. In order to complete the chronostratigraphic framework, we performed ESR and combined US-ESR dating applied to quartz grains extracted from sediments and fossil teeth, respectively. The results obtained are very significant, giving a weighted mean ESR age of 0.83 ± 0.13 Ma (2σ for the reference archaeological level of the site (level 10 and another of 0.79 ± 0.23 Ma (2σ for the archaeological level 12 of the Vallparadís sequence. These ESR results are in total agreement with the ones derived from biochronology and paleomagnetism. This whole dataset allows the elaboration of a reliable and consistent chronostratigraphic framework which chronologically places Vallparadís site in the late Early Pleistocene period, i.e. within a time range comprised between Jaramillo and Brunhes geomagnetic events. Consequently, as well as Gran Dolina-TD6 and Sima del Elefante- TE9 sites, in Atapuerca, Burgos, Vallparadís can be therefore considered as a key site for the study of early hominid settlements in Europe.Excavado entre 2005 y 2007, el yacimiento de Vallparadís (Terrassa, España ha aportado una fauna rica y diversa en asociación con un importante conjunto lítico de Modo 1. Con el objetivo de completar el marco cronoestratigráfico, se hicieron dataciones por los métodos de Resonancia Paramagnética Electrónica (Electron Spin Resonance, ESR y ESR combinada con uranio-torio sobre algunas muestras de granos de cuarzo extraídos de sedimentos y dientes fósiles, respectivamente. Los resultados obtenidos son muy significativos, ofreciendo edades ESR promedias de 0,83 ± 0,13 Ma (2σ para el nivel arqueológico de referencia del yacimiento (nivel 10 y de 0,79 ± 0,23 Ma (2σ para el nivel arqueológico 12 de la secuencia de Vallparadís. Dichos resultados por ESR concuerdan con los obtenidos a

  3. Granular model, percolation-resistivity, ESR and elastic modulus of carbonaceous materials application to the babassu endocarp heat treated up to 22000C

    International Nuclear Information System (INIS)

    Emmerich, F.G.

    1987-01-01

    A microscopic model (granular model) is presented to study heat treated carbons. A granular structure is defined in the carbon matrix, composed of turbostratic graphite-like microcrystallites, cross-linkings and micropores. A general expression is developed to calculate the volume fraction X of the conducting phase of the granular structure as a function of structural parameters obtained from X-ray diffraction small angle X-ray scattering. The granular model and the percolation theory are used to explain the electrical resistivity behaviour with the heat treatment temperature (HTT), where X is the fundamental parameter. An electron spin resonance (ESR) study of the low and high HTT ranges is presented, including the transition range (700-1300 0 C). The elucitation of the spin center nature in this range and the liking with the two adjacent ranges has been pursued. An expression to calculate the elastic modulus (Young's modulus), based on the microscopic granular model with the fundamental participation of the cross-linkings, is derived to account for the behavior of the modulus with the HTT. The granular model with the expression of X, the percolation-resistivity theory, the ESR study, and the expression of the elastic modulus are applied to the babassu endocarp carbon heat treated up to 2200 0 C. This material can be classified as a tipical non-graphitic carbon, being useful to search the validity of the model and the proposed expressions. It is observed that the theoretical expressions describe with reasonable accuracy the respective experimental behaviours. The measurements of physical and chemical parameters of the babassu endocarp treated up to 2200 0 C area also included. (author) [pt

  4. Development of multi-frequency ESR system for high-pressure measurements up to 2.5 GPa

    Science.gov (United States)

    Sakurai, T.; Fujimoto, K.; Matsui, R.; Kawasaki, K.; Okubo, S.; Ohta, H.; Matsubayashi, K.; Uwatoko, Y.; Tanaka, H.

    2015-10-01

    A new piston-cylinder pressure cell for electron spin resonance (ESR) has been developed. The pressure cell consists of a double-layer hybrid-type cylinder with internal components made of the ZrO2-based ceramics. It can generate a pressure of 2 GPa repeatedly and reaches a maximum pressure of around 2.5 GPa. A high-pressure ESR system using a cryogen-free superconducting magnet up 10 T has also been developed for this hybrid-type pressure cell. The frequency region is from 50 GHz to 400 GHz. This is the first time a pressure above 2 GPa has been achieved in multi-frequency ESR system using a piston-cylinder pressure cell. We demonstrate its potential by showing the results of the high-pressure ESR of the S = 1 system with the single ion anisotropy NiSnCl6 · 6H2O and the S = 1 / 2 quantum spin system CsCuCl3. We performed ESR measurements of these systems above 2 GPa successfully.

  5. Analysis of γ-ray irradiated pasteurized agaricus (Agaricus blazei Murill) by ESR in oxygen-free atmosphere

    International Nuclear Information System (INIS)

    Kemeya, Hiromi; Ukai, Mitsuko

    2007-01-01

    Agaricus (Agaricus blazei Murill) is one of a popular crude drug in Japan and East Asia countries. The crude drugs originating from natural raw products are easy to be contaminated by microorganism. Radiation method has been introduced as the sterilization technology for crude drugs. ESR has been used for the detection of radicals in irradiated drugs. Using ESR, we detected radical species in Agaricus before and after the gamma ray pasteurization. The ESR spectrum consists of a broad sextet centered at g=2.0, a singlet at same g-value and a singlet at g=4.0. We found that relaxation times of radicals in Agaricus varied by the presence of oxygen. Upon substitution of air by Ar, i.e., the absent of oxygen in the ESR sample tube, the T 1 value became 10 times larger than the presence of oxygen. Accordingly, the progressive saturation curve indicates more immediate saturation under the Ar than air atmosphere. Radicals, produced by the γ-ray irradiation to Agaricus, are very sensitive to oxygen. We concluded that ESR spectrum of irradiated Agaricus sample in the absence of oxygen is useful for the detection of dose level of γ-ray irradiation. (author)

  6. Declination Calculator

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Declination is calculated using the current International Geomagnetic Reference Field (IGRF) model. Declination is calculated using the current World Magnetic Model...

  7. Detection Characteristics of Gamma-Irradiated Seeds by using PSL, TL, ESR and GC/MS

    International Nuclear Information System (INIS)

    Kim, K.H.; Shon, J.H.; Kang, Y.J.; Jo, T.Y.; Park, H.Y.; Kwak, J.Y.; Lee, J.H.; Park, Y.C.; Kim, J.I.; Lee, H.J.; Lee, S.J.; Han, S.B.

    2013-01-01

    In this study, we investigated the applicability of the photostimulated luminescence (PSL), thermoluminescence (TL), electron spin resonance (ESR) and gas chromatography/mass spectrometry (GC/MS) methods for 5 seeds which are not allowed to be irradiated in Korea. All 5 seeds including evening primrose seed, safflower seed, rape seed, sunflower seed and flax seed were analyzed. Samples were irradiated at 1~10 kGy using a 60 Co gamma-ray irradiator. In PSL study, the photon counts of all the unirradiated samples showed negative (lower than 700). The photon counts of irradiated (1, 5, 10 kGy) samples showed positive (higher than 5,000). In TL analysis, results showed that it is possible to apply TL method to all foods containing minerals. In ESR measurements, the ESR signal (single-line) intensity of irradiated foods was higher than non-irradiated foods. The hydrocarbons 1,7-hexadecadiene (C 16:2 ) and 8-heptadecene (C 17:1 ) from oleic acid were detected only in the irradiated samples before and after the treatment at doses ≥ 1 kGy, but they were not detected in non-irradiated samples before and after treatment. These two hydrocarbons could be used as markers to identify irradiated safflower seed, rape seed, Sunflower seed and flax seed. And then, the hydrocarbons 1,7,10-hexadecatriene (C 16:3 ) and 6,9-heptadecadiene (C 17:2 ) from linoleic acid were detected in the evening primrose seed, safflower seed and sunflower seed. According to the results, PSL, TL and GC/ MS methods were successfully applied to detect the irradiated foods. It is concluded that PSL, TL and GC/MS methods are suitable for detection of irradiated samples and a combined method is recommendable for enhancing the reliability of detection results. (author)

  8. ESR detection of free radicals produced in irradiated fresh fruits and dried foods

    International Nuclear Information System (INIS)

    Bustos G, E.; Gomes, V.; Garcia, F.; Azorin, J.

    2007-01-01

    Full text: Electron spin resonance (ESR) technique was used to measure the stability of free radicals produced by the irradiation treatment in mangoes and in four spices: black pepper, oregano, 'guajillo' chili and 'morron' chili. The ESR spectra for mangoes were scanned in three different parts from the seeds and were recorded in fresh and dried tissues. The ESR spectra in fresh tissue of no irradiated mangoes, were a sextet line signal produced by Mn 2+ ion and a singlet centered at g = 2.00 produced by the endogenous radical. New resonances were observed in the irradiated samples at 1.5 mT and 3 mT respects to the center line for right and left side. These new resonance signals were-observed for eight days in mangoes treated at 1.00 kGy, and for three days at 0.15 kGy. The resonance due to the irradiation was observed in Iyophilized mangoes only one day after the treatment, in the vacuum dried samples, no new resonances were observed. The triplet signal, as well as the central single line appeared after irradiation in black pepper, morron chili and guajillo chili. These signals were also observed in the irradiated spices at any radiation dose higher than 1.0 kGy. The signals decrease promptly, in ten days after the 'irradiation. It was not possible to observe the triplet signal in oregano, even when the samples were analyzed immediately after irradiation treatment. The only signal observed in irradiated spice was the endogenous radical. This signal increased as the radiation dose increased and decreased during storage time at room temperature. Results showed that free radicals produced in irradiated fresh fruits or dried foods have a quick recombination. It was observed that in the spices the signal remains for several weeks meanwhile only eight days in mangoes. (Author)

  9. Proceedings of the workshop on experiments and experimental facilities at SIS/ESR

    International Nuclear Information System (INIS)

    1987-04-01

    The present proceedings contain the abstracts of the proposals and letters of intent prepared by the authors for general distribution. The abstracts are organized according to the sessions in which they were presented at the workshop. The program of the workshop is also included as is the list of attendees. In addition we have included two recent descriptions of the accelerator facilities providing information on the latest status of the expected beam schedule for SIS and performance characteristics of the ESR. (orig./HSI)

  10. Influence of Thermal Homogenization Treatment on Structure and Impact Toughness of H13 ESR Steel

    Institute of Scientific and Technical Information of China (English)

    MA Dang-shen; ZHOU Jian; CHEN Zai-zhi; ZHANG Zhong-kan; CHEN Qi-an; LI De-hui

    2009-01-01

    The as-cast microstrueture of H13 ESR ingot and the influence of high temperature diffusion treatment on the structure and impact toughness have been investigated. The results show that the dendrite arm spacing gradually becomes wide from the surface to the center of ingot, and the large primary carbide particles always exist in interdendritic segregation areas; by means of high temperature diffusion treatment of ingot prior to hot forging, the banded segregation is nearly eliminated, the annealed structure is more uniform and the isotropic properties have been improved remarkably.

  11. ESR identification of irradiated foodstuffs. Detection par RPE d'aliments ionises

    Energy Technology Data Exchange (ETDEWEB)

    Raffi, J. (CEA Centre d' Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Physiologie Vegetale et Ecosystemes); Belliardo, J.J. (Commission of the European Communities, Brussels (Belgium))

    1993-04-01

    The conditions required to use Electron Spin Resonance (ESR) in identification of irradiated foods is first described. Then we present the results of an intercomparison sponsored by the Community Bureau of Reference involving 22 european laboratories. Qualitative identification of irradiated beef bones, dried grapes and papaya is very easy. Kinetical studies are necessary in case of fish species. Further researches are required in case of pistachio-nuts. Although all laboratories could distinguish between the two dose ranges used in case of meat bones (i.e. 1-3 and 7-10 kGy), there is an overlap of the results from the different laboratories. 2 tabs., 3 figs.

  12. ESR identification of irradiated foodstuffs. Detection par RPE d'aliments ionises

    Energy Technology Data Exchange (ETDEWEB)

    Raffi, J [CEA Centre d' Etudes de Cadarache, 13 - Saint-Paul-lez-Durance (France). Dept. de Physiologie Vegetale et Ecosystemes; Belliardo, J J [Commission of the European Communities, Brussels (Belgium)

    1993-04-01

    The conditions required to use Electron Spin Resonance (ESR) in identification of irradiated foods is first described. Then we present the results of an intercomparison sponsored by the Community Bureau of Reference involving 22 european laboratories. Qualitative identification of irradiated beef bones, dried grapes and papaya is very easy. Kinetical studies are necessary in case of fish species. Further researches are required in case of pistachio-nuts. Although all laboratories could distinguish between the two dose ranges used in case of meat bones (i.e. 1-3 and 7-10 kGy), there is an overlap of the results from the different laboratories. 2 tabs., 3 figs.

  13. ESR measurement of the concentration of vibrationally excited hydrogen and deuterium molecules

    International Nuclear Information System (INIS)

    Gershenzon, Yu.M.; Ivanov, A.V.; Il'in, S.D.; Kucheryavyi, S.I.; Rozenshtein, V.B.

    1988-01-01

    A method is described for measuring the concentration of vibrationally excited H 2 and D 2 molecules using an ESR microwave spectrometer. The essence of the method is the titration of H 2 (v = 1) and D 2 (v = 1) with D and H atoms and measurement of the concentrations of the titration products H and D, respectively. Stoichiometric titration coefficients were determined in the form of proportionality coefficients between the titration signals Δ[H], Δ[D] and the concentrations of H 2 (v = 1), D 2 (v = 1)

  14. Quality assessment of coffee beans with ESR and gamma-ray irradiation

    International Nuclear Information System (INIS)

    Ikeya, Motoji; Baffa, F.O.; Mascarenhas, Sergio

    1989-01-01

    Peroxy radical formation in raw coffee beans of different qualities and origins from all over the world has been studied with electron spin resonance (ESR) analysis. The γ-ray equivalent absorbed dose (ED) which creates the same concentration of radicals is obtained by the additive γ-ray irradiation of the coffee beans. The ED and the cup quality is somewhat inversely related suggesting that the peroxidation of the unsaturated fatty acid is somewhat indicative of the degree of the aromatic decomposition and rancidity. (author)

  15. E.S.R. studies of mechanisms of radiation protection effect by cysteine and cystine

    International Nuclear Information System (INIS)

    Xue-Peng, L.; Tie-Cheng, T.; Nian-Yun, L.

    1981-01-01

    By means of E.S.R. the repair mechanism of radiation induced spin transfer from dTMP to cysteine in binary system dTMP-cysteine has been confirmed. Furthermore, a new marked radiation protection effect, exerted by cysteine or cystine on thymine irradiated and observed at low temperature, has been detected. Another sort of fast protection mechanism, including electron transfer and excitation transfer, has been proposed, based on recent advances of primary radiation process of pyrimidine bases and analysed by molecular orbital theory. This fast radiation protection mechanism provides the possibility to utilize electrophilic sulfhydryl protectors for realizing excellent protection effect. (author)

  16. Thermal behaviour of the ESR Relaxation time in slightly dirty superconductors

    International Nuclear Information System (INIS)

    Schwachheim, G.; Machado, S.F.; Tsallis, C.

    1978-07-01

    The thermal behaviour of the ESR relaxation rate in slightly dirty superconductors is discussed for both exchange and spin-orbit interactions between the conduction electrons and the impurities. The sensibility to the electronic density of states is exhibited by using, in a modified BCS framework, an heuristic analytic form which avoids two of three defects of a previous similar treatment. The sudden increase (decrease) of the relaxation rate immediately below the critical temperature for the exchange (spin-orbit) case is confirmed. Reasonable agreement with experimental data in LaRu 2 ; Gd is obtained [pt

  17. The EXL experiment at FAIR and plans with the ESR at GSI

    International Nuclear Information System (INIS)

    Kalantar-Nayestanaki, N.

    2011-01-01

    In this contribution, the physics program of the EXL experiment at FAIR-NuSTAR along with its experimental setup will be briefly outlined. This experiment aims to study the structure and the dynamics of radioactive nuclei which collide with light ions in inverse kinematics. On the way to the final measurements, several measurements have been proposed at the existing ESR at GSI with the purpose of understanding the detection systems for EXL and obtaining the first physics results in this type of experiments in a storage ring.

  18. Retrospective Dosimetry: Dose Analysis From Tooth Enamel Using Electron Spin Resonance (ESR)

    International Nuclear Information System (INIS)

    Mohd Rodzi Ali; Rahimah Abdul Rahim; Noraisyah Yusof; Syed Asraf Fahlawi Wafa Syed Mohd Ghazi; Juliana Mahamad Napiah; Yahaya Talib; Rehir Dahalan

    2014-01-01

    The radiation dose should be accurately measured in order to relate its effect to the cells. The assessment of dose usually performed using biological dosimetry techniques. However, the reduction of lymphocytes (white blood cells) after the time period results in inaccuracy of dose measurement. An alternative method used is the application of Electron Spin Resonance (ESR) using tooth enamel. In this study, tooth enamels were evaluated and used to measure the individual absorbed dose from the background. The basic tooth features that would affect dose measurement were discussed. The results show this technique is capable and effective for retrospective dose measurement and useful for the study of radiation effect to human. (author)

  19. A simple method for the rapid assessment of the qualitative ESR response of fossil samples to laboratory irradiation

    International Nuclear Information System (INIS)

    Gruen, Rainer

    2006-01-01

    A simple and effective method is proposed for the analysis of the qualitative response of ESR spectra to dosing. The method comprises of the alignment of the spectra, and subtraction of the natural spectrum from those that were subsequently irradiated in the laboratory. In that way, the ESR response to environmental radiation can be compared to the ESR response to laboratory radiation. As illustrated on some tooth enamel and mollusk shell samples, both materials are frequently used in dating and accident dosimetry, the method is very effective for the identification of regions where the two radiation regimes generate qualitatively the same dose response as well as for the isolation of radiation insensitive signals that interfere with those used for dose estimation

  20. Estimation of accumulated dose of radiation by the method of ESR-spectrometry of dental enamel of mammals

    International Nuclear Information System (INIS)

    Serezhenkov, V.A.; Moroz, I.A.; Vanin, A.F.; Klevezal, G.A.

    1997-01-01

    ESR-spectrometry was used to investigate radiation-induced paramagnetic centers in enamel of mammals: carnivores (polar bear and fox), ungulates (reindeer, European bison, moose), and man. Values at half the microwave power saturation of the radiation signal, P 1/2 , evaluated at room temperature, was found to range from 16 to 26 mW for animals and man. A new approach to discrimination of the radiation induced signal from the total ESR spectrum of reindeer enamel is proposed. ''Dose-response'' dependencies of enamel of different species mammals were measured within the dose range from 0.48 up to 10.08 Gy. Estimations of ''radiosensitivity'' enamel of carnivores and ungulates showed good agreement with radiosensitivity enamel of man by ESR method. (Author)

  1. Hodgkin's disease and age

    DEFF Research Database (Denmark)

    Specht, L; Nissen, N I

    1989-01-01

    506 unselected, previously untreated patients with Hodgkin's disease were treated at the Finsen Institute between 1969 and 1983. The prognostic significance of age, sex, stage, systemic symptoms, histologic subtype, number of involved nodal regions, total tumour burden (peripheral + intrathoracic...... nodal tumour burden, intraabdominal nodal tumour burden, and number of involved extranodal sites), pretreatment ESR, lymphocytopenia, and treatment modality were examined in multivariate analyses. The only factors of independent prognostic significance for disease-free survival proved to be treatment...... modality, stage, and total tumour burden, whereas age had no prognostic significance. With regard to death from Hodgkin's disease only age and total tumour burden had independent significance. The significance of age would seem to stem from the fact that some older patients could not be given adequate...

  2. The nitrogen acceptor in 2H-Polytype synthetic MoS2. Frequency and temperature dependent ESR analysis

    International Nuclear Information System (INIS)

    Schoenaers, Ben; Stesmans, Andre; Afanas'ev, Valery V.

    2017-01-01

    In extending on recent electron spin resonance (ESR) work which has revealed the N acceptor (N substituting for S site) in 2H-polytype bulk synthetic MoS 2 , the dopant is extensively analyzed in terms of its frequency, temperature (T), and magnetic field B angular dependent ESR spectral characteristics. For B parallel c-axis, the multi-frequency analysis confirms the ESR spectrum as being composed of a 14 N hyperfine (hf) triplet with hf splitting constant A parallel = 14.7 ± 0.2 G (B parallel c-axis) and making up ∼74% of the total spectrum intensity, superimposed on a central line centered at about equal g-value [g parallel = 2.032(2)]. The presence of the latter signal, points to some non-uniformity in dopant distribution, that is, clustering, with about ∼26% of the total N response not originating from N incorporated in the preferred ''isolated'' dopant configuration. Angular dependent measurements reveal distinct anisotropy of the hf matrix, whereas ESR probing over a wide T-range exposes drastic signal broadening with increasing T above ∼150 K. Detailed study of the N acceptor signal intensity versus T at Q-band reveals an activation energy E a = 50 ± 10 meV, herewith consolidating the value reported initially. Besides unveiling the S-site substitutional N impurity as an appropriate p-type dopant for MoS 2 , the total of the ESR work establishes a basic frame of the N acceptor ESR characteristics, giving way for further in-depth theoretical perusal. (copyright 2017 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  3. First direct mass measurements of stored neutron-rich 129,130,131Cd isotopes with FRS-ESR

    Directory of Open Access Journals (Sweden)

    R. Knöbel

    2016-03-01

    Full Text Available A 410 MeV/u 238U projectile beam was used to create cadmium isotopes via abrasion-fission in a beryllium target placed at the entrance of the in-flight separator FRS at GSI. The fission fragments were separated by the FRS and injected into the isochronous storage ring ESR for mass measurements. Isochronous Mass Spectrometry (IMS was performed under two different experimental conditions, with and without Bρ-tagging at the high-resolution central focal plane of the FRS. In the experiment with Bρ-tagging the magnetic rigidity of the injected fragments was determined with an accuracy of 2⋅10−4. A new method of data analysis, which uses a correlation matrix for the combined data set from both experiments, has provided experimental mass values of 25 rare isotopes for the first time. The high sensitivity and selectivity of the method have given access to nuclides detected with a rate of a few atoms per week. In this letter we present for the 129,130,131Cd isotopes mass values directly measured for the first time. The experimental mass values of cadmium as well as for tellurium and tin isotopes show a pronounced shell effect towards and at N=82. Shell quenching cannot be deduced from a single new mass value, nor by a better agreement with a theoretical model which explicitly takes into account a quenching feature. This is in agreement with the conclusion from γ-ray spectroscopy and confirms modern shell-model calculations.

  4. ESR detection of free radicals in gamma irradiated spices and other foodstuffs

    Energy Technology Data Exchange (ETDEWEB)

    Pilbrow, J.R.; Troup, G.J.; Hutton, D.R. [Monash Univ., Clayton, VIC (Australia). Dept. of Physics; Hunter, C.R. [Monash Univ., Clayton, VIC (Australia). Dept. of Astronomy

    1996-12-31

    Irradiation of various food products, including vegetables, fruits, meats, seafoods, herbs, spices and seeds by appropriate doses of {gamma}-rays has for many years been suggested as a means of killing or sterilizing bacteria, viruses and pests and, therefore, as a means of preserving the foods. The position of food irradiation has been under review in Australia generally, through consumer organisations and by a Federal Government (House of Representatives) inquiry. From these reviews and inquiries, recommendations for irradiation, packaging, and labelling etc., are emerging with, for example, an NH and MRC recommended maximum dose of 10 kGy for Australia, with 6 kGy being a minimum dose for grains and spices. In early studies, electron spin resonance (ESR) spectroscopy was used to detect stable free radicals in bone and cuticle and it was demonstrated that {gamma}-irradiation breaks down proteins and DNA. Earlier studies suggested that induced free radical signals in spices rapidly decayed to negligible levels after three weeks, especially if some moisture was present. Although the members of the Monash group do not carry out research formally in the area of food technology, participation in the ADMIT program was appropriate given the availability of suitable ESR and {sup 137}Cs irradiation facilities and interest both politically and amongst consumer groups regarding food irradiation. (author).

  5. Oxygen diffusion-concentration in phospholipidic model membranes. An ESR-saturation study

    International Nuclear Information System (INIS)

    Vachon, A.; Lecomte, C.; Berleur, F.

    1986-04-01

    Fully hydrated liposomes of dipalmitoyl-phosphatidylcholine were labelled with 5 (or 7, 10, 12, 16)-doxyl stearic acid at pH 6 and 8, and studied by the continuous wave ESR-saturation technique. The ESR spectral magnitude depends on the hyperfrequency power P and on both T 1 and T 2 relaxation times. Saturation, i.e. the non linearity of the spectral magnitude plotted versus √P can be quantified by a P1/2 parameter (power at which the signal is half as great as it would be without saturation). If we assume T 2 weakly modified by spin exchange between paramagnetic spin probe and oxygen in triplet state, P1/2 is inversely proportional to T 1 , and becomes a sensitive parameter to appreciate the oxygen transport (oxygen diffusion-concentration product) inside the bilayers. According to the DPPC bilayer phase transition diagrams, P1/2 (oxygen diffusion-concentration) is related to the thermodynamic state of the membrane. This technique provides further informations on a particular property of a radioprotective agent, cysteamine, which seems to inhibit spin-triplet exchange and hence maximizes T 1 (minimizes P1/2). Since radioprotective agents are known to act by scavenging radiation-induced free radicals and by inhibiting oxygen-dependent free radical processes, such a result may contribute to elucidate radioprotecting mechanisms

  6. Influence of the Mg-content on ESR-signals in synthetic calcium carbonate

    International Nuclear Information System (INIS)

    Barabas, M.; Bach, A.; Mudelsee, M.; Mangini, A.

    1989-01-01

    Carbonate crystals doped with various concentrations of Mg 2+ -ions have been grown by a gel-diffusion method. An increase of the Mg/Ca-ratio to more than about 1 caused a phase change in the crystal lattice from calcite to aragonite. The properties of the ESR-signals of the synthetic carbonates were studied and compared with natural marine carbonates. The following results were derived: (a) In the presence of Mg 2+ -ions the synthetic carbonates display the same ESR-signals as natural calcites of marine origin with similar properties (thermal stability, radiation sensitivity). (b) The saturation value of the signal at g=2.0006 in synthetic calcites was found to be strongly related with the Mg-content in the crystals. (c) The signal at g=2.0036 (axial symmetry) which is present in calcite was not influenced by the Mg-concentration. Its saturation value decreases when the crystal phase changed from calcite to aragonite and in complement the signal at g=2.0031 appeared. (d) The signals at g=2.0057 and g=2.0031 are most probably not of organic origin. (author)

  7. ESR study of the effects of water, methanol, and ethanol on gamma-irradiation of starch

    International Nuclear Information System (INIS)

    Henderson, A.M.; Rudin, A.

    1981-01-01

    This investigation deals with the nature and relative abundance of stable radicals formed by gamma-irradiation of wheat starch at room temperature. Additions of equal weights of water, methanol, and ethanol were equally effective in reducing the content of stable radicals in starch which contained about 12% water before the additions. When, however, the starting material was dried starch with 2.9% initial water content additional water and methanol were better radical scavengers than ethanol. This difference is attributed to the superior ability of water and methanol to permeate the starch structure. Superficially different ESR spectra were obtained in products made by irradiating starch and starch that contained added water or methanol. Computer simulation of these spectra showed that they could be matched by superposition of the spectra of the same four component radicals, with some adjustments of relative intensities and peak widths. The structure of these radicals have been deduced from the spectral assignments and relative effects of the three solvents used on the intensities of the respective ESR spectra

  8. Experiments with highly-charged heavy-ions performed at the storage ring ESR

    International Nuclear Information System (INIS)

    Mokler, P.H.

    1992-01-01

    The new heavy ion accelerator facility SIS/ESR was inaugurated in April 1990. During 1991 the experimental storage ring, ESR, has been commissioned. Highly-charged heavy ions from O 8+ up to Bi 82+ were successfully accumulated, cooled, and stored in the ring. Now all highly-charged, heavy ions can be provided for experiments at comfortable storage times and at energies roughly between 100 and 500 MeV/u. A report on the achievements and on the first experimental results will be given. For the experiments, special emphasis is put on capture processes in the electron cooler, i.e. on radiative and dielectronic recombination processes as well as on capture events of bound target electrons from a gas jet. In this case, the capture leads either directly (REC) or by cascading to X-ray emission, which is also exploited for a precision spectroscopy of the structure of the heaviest ions. Another exciting topic is the radioactive decay of highly charged ions: For instance the β-decay into bound atomic states, which is not possible for neutral atoms, was studied for stored naked Dy ions. (orig.)

  9. Association of ESR1 gene tagging SNPs with breast cancer risk

    Science.gov (United States)

    Dunning, Alison M.; Healey, Catherine S.; Baynes, Caroline; Maia, Ana-Teresa; Scollen, Serena; Vega, Ana; Rodríguez, Raquel; Barbosa-Morais, Nuno L.; Ponder, Bruce A.J.; Low, Yen-Ling; Bingham, Sheila; Haiman, Christopher A.; Le Marchand, Loic; Broeks, Annegien; Schmidt, Marjanka K.; Hopper, John; Southey, Melissa; Beckmann, Matthias W.; Fasching, Peter A.; Peto, Julian; Johnson, Nichola; Bojesen, Stig E.; Nordestgaard, Børge; Milne, Roger L.; Benitez, Javier; Hamann, Ute; Ko, Yon; Schmutzler, Rita K.; Burwinkel, Barbara; Schürmann, Peter; Dörk, Thilo; Heikkinen, Tuomas; Nevanlinna, Heli; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kosma, Veli-Matti; Chen, Xiaoqing; Spurdle, Amanda; Change-Claude, Jenny; Flesch-Janys, Dieter; Couch, Fergus J.; Olson, Janet E.; Severi, Gianluca; Baglietto, Laura; Børresen-Dale, Anne-Lise; Kristensen, Vessela; Hunter, David J.; Hankinson, Susan E.; Devilee, Peter; Vreeswijk, Maaike; Lissowska, Jolanta; Brinton, Louise; Liu, Jianjun; Hall, Per; Kang, Daehee; Yoo, Keun-Young; Shen, Chen-Yang; Yu, Jyh-Cherng; Anton-Culver, Hoda; Ziogoas, Argyrios; Sigurdson, Alice; Struewing, Jeff; Easton, Douglas F.; Garcia-Closas, Montserrat; Humphreys, Manjeet K.; Morrison, Jonathan; Pharoah, Paul D.P.; Pooley, Karen A.; Chenevix-Trench, Georgia

    2009-01-01

    We have conducted a three-stage, comprehensive single nucleotide polymorphism (SNP)-tagging association study of ESR1 gene variants (SNPs) in more than 55 000 breast cancer cases and controls from studies within the Breast Cancer Association Consortium (BCAC). No large risks or highly significant associations were revealed. SNP rs3020314, tagging a region of ESR1 intron 4, is associated with an increase in breast cancer susceptibility with a dominant mode of action in European populations. Carriers of the c-allele have an odds ratio (OR) of 1.05 [95% Confidence Intervals (CI) 1.02–1.09] relative to t-allele homozygotes, P = 0.004. There is significant heterogeneity between studies, P = 0.002. The increased risk appears largely confined to oestrogen receptor-positive tumour risk. The region tagged by SNP rs3020314 contains sequence that is more highly conserved across mammalian species than the rest of intron 4, and it may subtly alter the ratio of two mRNA splice forms. PMID:19126777

  10. ESR Study of PE, HDPE and UHMWPE Irradiated with Ion Beams and Neutrons

    International Nuclear Information System (INIS)

    Reyes-Romero, J.

    2006-01-01

    We report the Electron Spin Resonance (RES) studies on the effects produced by bombarding with accelerated Sulfur ions, Protons and Neutrons on the Polyethylene, PE, (Hostalen and Romanian), ultra-high molecular weight polyethylene, UHMWPE, ( GUR 1050, medical grade Lennite), and high density polyethylene, HDPE, (HDPE-7000F, Polinter de Venezuela, PDVSA). The resonance spectra have been recorded using a Varian E-line-X ESR spectrometer at 100 KHz modulation frequency. In thin films of Polyethylene (Hostalen and UHMWPE) have been irradiated with Sulfur ions, S, accelerated at about 7 MeV/nucleons, and Protons at about 5 MeV/nucleons (IFIN, Romania). Samples of Polyethylene ( HDPE 7000-F) were irradiate with neutrons from a Pu-Be source (flux of 1.19 x 10 6 n/s. cm 2 , 5.65 MeV, IVIC, Venezuela) from 0 to 8 hours in the presence of air and at room temperature (RT). The ESR measurements were performed after a storage time of about 7 months, in air at room temperature. The nature of the free radicals induced by irradiation as well as the dependence of resonance line, resonance line shape and radicals concentration has been studied

  11. ESR studies on the effects of ionizing radiation in biological media

    International Nuclear Information System (INIS)

    Stockhausen, K.

    1976-01-01

    The various effects of molecular oxygen on the radiosensitivity of bacteria is closely connected with the development of peroxyradicals during radiation exposure and their effects. Irradiated 'molecular mixtures' consisting of sephadex and penicillamine show the phenomenon of energy transfer. This might be a fundamental aspect of the damage to biomolecules on the one hand and of the molecular radiation protection on the other. Very closely connected with this phenomenon is the 'repair' of damaged cell modules by radioprotective substances, such as amino acids containing sulphur. Damaged heads of the spermatozoons of herrings are obviously 'repaired' during storage of several days' duration at room temperature if a few percent of the immunizing substance mercaptoethylamine are added to them during irradiation. ESR-examinations of DNA and its components make the mutagenic effect of ionising radiation plausible. They give information about the points in these macromolecules in which radicals are localized. Quantitative determinations of the yield of radicals in each component of the DNA show that there are significant differences in the radiosensitivity of the different DNA-modules and that energy transfer processes can take place within the macromolecule. Longlived radicals in certain tissues of the living organism, such as bones, fingernails, or teeth, can be very useful to develop methods of dosimetry after radiation accidents and of radiotherapy with the help of the help of the ESR-techniques. (orig.) [de

  12. ESR detection of free radicals in gamma irradiated spices and other foodstuffs

    International Nuclear Information System (INIS)

    Pilbrow, J.R.; Troup, G.J.; Hutton, D.R.; Hunter, C.R.

    1996-01-01

    Irradiation of various food products, including vegetables, fruits, meats, seafoods, herbs, spices and seeds by appropriate doses of γ-rays has for many years been suggested as a means of killing or sterilizing bacteria, viruses and pests and, therefore, as a means of preserving the foods. The position of food irradiation has been under review in Australia generally, through consumer organisations and by a Federal Government (House of Representatives) inquiry. From these reviews and inquiries, recommendations for irradiation, packaging, and labelling etc., are emerging with, for example, an NH and MRC recommended maximum dose of 10 kGy for Australia, with 6 kGy being a minimum dose for grains and spices. In early studies, electron spin resonance (ESR) spectroscopy was used to detect stable free radicals in bone and cuticle and it was demonstrated that γ-irradiation breaks down proteins and DNA. Earlier studies suggested that induced free radical signals in spices rapidly decayed to negligible levels after three weeks, especially if some moisture was present. Although the members of the Monash group do not carry out research formally in the area of food technology, participation in the ADMIT program was appropriate given the availability of suitable ESR and 137 Cs irradiation facilities and interest both politically and amongst consumer groups regarding food irradiation. (author)

  13. ESR spectroscopy of blood serum in thalassemia: computer simulation of methemalbumin spectrum

    International Nuclear Information System (INIS)

    Preoteasa, E.A.; Duliu, O.G.; Grecu, V.V.; Schianchi, G.; Giori, D.C.; Pedrazzi, G.

    1997-01-01

    In pathological states with severe hemolysis such as homozygous β-thalassemia, human serum albumin (HSA) binds ferric heme to form the methemalbumin (MHA) molecular complex. Low-temperature X-band ESR monitored MHA in patients' serum, while in vitro studies prompted a molecular model for the complex. On the assumption of axial symmetry with small rhombic distortion for high spin Fe (III) in MHA, we used a simulation program written in FORTRAN V for ESR spectra of vitreous samples containing subsystems with effective electronic spin S' = 1/2 and nuclear spin I ≥ 0. We have take also into account the individual resonance line shape and half-width, and the magnetic field dependence of the transition probability. Two distinct forms of MHA were found in patients' serum, the second one showing a stronger rhombic distortion around Fe (III) as compared to the in-vitro complex. This suggested a conformational change of HSA around heme binding site, possibly produced by free radicals occurring in thalassemia intense oxidative stress; these could generate more forms of MHA. (authors)

  14. Identification of. gamma. -irradiated spices by electron spin resonance (ESR) spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Uchiyama, Sadao; Kawamura, Yoko; Saito, Yukio (National Inst. of Hygienic Sciences, Tokyo (Japan))

    1990-12-01

    The electron spin resonance (ESR) spectrometry spectra of white (WP), black (BP) and red (Capsicum annuum L. var. frutescerns L., RP) peppers each had a principal signal with a g-value of 2.0043, and the intensities of the principal signals were increased not only by {gamma}-irradiation but also by heating. Irradiated RP also showed a minor signal -30G from the principal one, and the intensity of the minor signal increased linearly with increasing dose from 10 to 50 kGy. Since the minor signal was observed in RP irradiated at 10 kGy and stored for one year, but did not appear either after heating or after exposure to this signal is unique to {gamma}-irradiated RP and should therefore be useful for the identification of {gamma}-irradiated spices of Capsicum genus, such as paprika and chili pepper. The computer simulation of the ESR spectra suggested that the minor signal should be assigned to methyl radical and the principal signal mainly to a combination of phenoxyl and peroxyl radicals. Such minor signals were found in {gamma}-irradiated allspice and cinnamon among 10 kinds of other spices. (author).

  15. Identification of γ-irradiated spices by electron spin resonance (ESR) spectrometry

    International Nuclear Information System (INIS)

    Uchiyama, Sadao; Kawamura, Yoko; Saito, Yukio

    1990-01-01

    The electron spin resonance (ESR) spectrometry spectra of white (WP), black (BP) and red (Capsicum annuum L. var. frutescerns L., RP) peppers each had a principal signal with a g-value of 2.0043, and the intensities of the principal signals were increased not only by γ-irradiation but also by heating. Irradiated RP also showed a minor signal -30G from the principal one, and the intensity of the minor signal increased linearly with increasing dose from 10 to 50 kGy. Since the minor signal was observed in RP irradiated at 10 kGy and stored for one year, but did not appear either after heating or after exposure to this signal is unique to γ-irradiated RP and should therefore be useful for the identification of γ-irradiated spices of Capsicum genus, such as paprika and chili pepper. The computer simulation of the ESR spectra suggested that the minor signal should be assigned to methyl radical and the principal signal mainly to a combination of phenoxyl and peroxyl radicals. Such minor signals were found in γ-irradiated allspice and cinnamon among 10 kinds of other spices. (author)

  16. Synthesis of silver nanoparticles using DL-alanine for ESR dosimetry applications

    International Nuclear Information System (INIS)

    Guidelli, Eder José; Ramos, Ana Paula; Zaniquelli, Maria Elisabete D.; Nicolucci, Patricia; Baffa, Oswaldo

    2012-01-01

    The potential use of alanine for the production of nanoparticles is presented here for the first time. Silver nanoparticles were synthesized using a simple green method, namely the thermal treatment of silver nitrate aqueous solutions with DL-alanine. The latter compound was employed both as a reducing and a capping agent. Particles with average size equal to 7.5 nm, face-centered cubic crystalline structure, narrow size distribution, and spherical shape were obtained. Interaction between the silver ions present on the surface of the nanoparticles and the amine group of the DL-alanine molecule seems to be responsible for reduction of the silver ions and for the stability of the colloid. The bio-hybrid nano-composite was used as an ESR dosimeter. The amount of silver nanoparticles in the nanocomposite was not sufficient to cause considerable loss of tissue equivalency. Moreover, the samples containing nanoparticles presented increased sensitivity and reduced energetic dependence as compared with pure DL-alanine, contributing to the construction of small-sized dosimeters. - Highlights: ► The synthesis is environmentally benign, easy to perform, and of low-cost. ► DL-Alanine was employed both as reducing and capping agent. ► Mean size of 7.5 nm, narrow size distribution, and spherical shape of particles. ► Increased sensitivity and reduced energetic dependence compared with pure alanine. ► The nanocomposite has potential application for ESR dosimetry.

  17. Origin of the ESR spectrum in the Prussian blue analog RbMn[Fe(CN)(6)]center dot H2O

    NARCIS (Netherlands)

    Antal, A.; Janossy, A.; Forro, L.; Vertelman, E. J. M.; van Koningsbruggen, P. J.; van Loosdrecht, P. H. M.

    2010-01-01

    We present an electron spin resonance (ESR) study at excitation frequencies of 9.4 and 222.4 GHz of powders and single crystals of a Prussian blue analog (PBA), RbMn[Fe(CN)(6)]center dot H2O in which Fe and Mn undergoes a charge-transfer transition between 175 and 300 K. The ESR of PBA powders, also

  18. LncRNA LINC01116 competes with miR-145 for the regulation of ESR1 expression in breast cancer.

    Science.gov (United States)

    Hu, H-B; Chen, Q; Ding, S-Q

    2018-04-01

    To investigate the biological role and clinical significance of long non-coding RNAs (lncRNA) LINC01116 in breast cancer. In the public database Gene Expression Omnibus (GEO), the breast cancer data set GSE54002 was screened for differentially expressed lncRNA LINC01116 in breast cancer tissues and paracancerous tissues. Quantitative Real-time polymerase chain reaction (qRT-PCR) was used to detect the expression of LINC01116 in 64 breast cancer tissues and 30 normal breast tissues. Level of LINC01116 and clinicopathological parameters of breast cancer were statistically analyzed. The effect of LINC01116 in breast cancer cells was investigated after knockdown of LINC01116. Luciferase reporter gene was further used to investigate the mechanism of endogenous RNA (ceRNA). Results of GSE54002 showed that the expression of LINC01116 in breast cancer tissues was significantly increased. In clinical samples, the level of LINC01116 in patients with breast cancer was significantly increased, which was correlated with the overall survival, tumor size and tumor node metastasis (TNM) stage in patients, but not correlated with the age, sex and lymph node metastasis (p>0.05). LINC01116 can act as an endogenous sponge and bind directly to miR-145, resulting in the up-regulation of estrogen receptor 1 (ESR1), a target gene of miR-145. LncRNA LINC01116 is highly expressed in breast cancer and is a new prognostic biomarker in breast cancer. Our study establishes a new link between LINC01116, miR-145 and ESR1.

  19. An Endogenous Electron Spin Resonance (ESR signal discriminates nevi from melanomas in human specimens: a step forward in its diagnostic application.

    Directory of Open Access Journals (Sweden)

    Eleonora Cesareo

    Full Text Available Given the specific melanin-associated paramagnetic features, the Electron Spin Resonance (ESR, called also Electron Paramagnetic Resonance, EPR analysis has been proposed as a potential tool for non-invasive melanoma diagnosis. However, studies comparing human melanoma tissues to the most appropriate physiological counterpart (nevi have not been performed, and ESR direct correlation with melanoma clinical features has never been investigated. ESR spectrum was obtained from melanoma and non-melanoma cell-cultures as well as mouse melanoma and non-melanoma tissues and an endogenous ESR signal (g = 2.005 was found in human melanoma cells and in primary melanoma tissues explanted from mice, while it was always absent in non-melanoma samples. These characteristics of the measured ESR signal strongly suggested its connection with melanin. Quantitative analyses were then performed on paraffin-embedded human melanoma and nevus sections, and validated on an independent larger validation set, for a total of 112 sections (52 melanomas, 60 nevi. The ESR signal was significantly higher in melanomas (p = 0.0002 and was significantly different between "Low Breslow's and "High Breslow's" depth melanomas (p<0.0001. A direct correlation between ESR signal and Breslow's depth, expressed in millimetres, was found (R = 0.57; p<0.0001. The eu/pheomelanin ratio was found to be significantly different in melanomas "Low Breslow's" vs melanomas "High Breslow's" depth and in nevi vs melanomas "High Breslow's depth". Finally, ROC analysis using ESR data discriminated melanomas sections from nevi sections with up to 90% accuracy and p<0.0002. In the present study we report for the first time that ESR signal in human paraffin-embedded nevi is significantly lower than signal in human melanomas suggesting that spectrum variations may be related to qualitative melanin differences specifically occurring in melanoma cells. We therefore conclude that this ESR signal

  20. Study of two new methods of geochronometry: dating method of carbonaceous formations by U-series disequilibrium gamma spectrometry; ESR dating method of rich U-content fossil dental enamel

    International Nuclear Information System (INIS)

    Ma, Jean-Luc

    1984-01-01

    First, the U-series disequilibrium dating method was re-examined using non-destructive γ-spectrometry. A new low-background (≤ 10 ppb U- equivalent) Ge-HP γ-spectrometer has been used to date travertine with small U-content (∼ 0.1 ppm) and low (≤ 5%) Th/U , content, by comparison with old-limestone γ-spectra. Second, a new ESR dating method has been developed using fossil dental enamel which is rich in U-content (10 - 100 ppm). Both methods were applied to Arago Cave (Tautavel, France): - with an ionium-age of 120 ka (10%), the upper travertine seems to have been set up during the Riss-deglaciation period. - the high (∼ 50%) Th/U-content samples of the intermediate travertine are un-datable. - the ESR-age of EQUUS mosbachensis enamel is 400 ka (10%) for the G-soil of Arago. XXI H. erectus, and 600 ka (10%) for the Q-soil above (- 1 m) of the lower travertine of which Io-age is older than 350 ka. (author)

  1. Association study of the estrogen receptor I gene (ESR1) in anorexia nervosa and eating disorders: No replication found

    NARCIS (Netherlands)

    Slof-Op 't Landt, M.C.T.; van Furth, E.F.; Meulenbelt, I.; Bartels, M.; Slagboom, P.E.; Boomsma, D.I.

    2014-01-01

    Objective The female preponderance and onset around puberty in the majority of eating disorders (EDs) suggest that sex hormones, like estrogens, may be involved in the onset of these disorders. An eight-SNP haplotype at the estrogen receptor I (ESR1) gene was found to be associated with anorexia

  2. Dating of the middle Palaeolithic site of Payre (Ardeche): new radiometric data (U-series and ESR methods)

    International Nuclear Information System (INIS)

    Masaoudi, H.; Falgueres, Ch.; Bahain, J.J.; Moncel, M.H.

    1997-01-01

    The site of Payre is located in Ardeche. Several archaeological layers containing lithic artefacts of Middle Palaeolithic were found. These artefacts lie associated with carbonate formations which are good chronostratigraphic markers. The U-series and ESR methods on bones and stalagmitic floors placed the human occupation between isotopic marine stages 7 and 4. (authors)

  3. ESR spectroscopy of blood serum in thalassemia: discrimination of iron overload severity in deferoxamine-cured patients

    International Nuclear Information System (INIS)

    Preoteasa, E.A.; Schianchi, G.; Giori, D.C.; Pedrazzi, G.

    1997-01-01

    Iron impairments in homozygous β-thalassemia include iron overload syndrome, partially prevented by deferoxamine (DF) and methemalbumin (MHA) in serum. The latter has been studied by electron spin resonance ESR before the clinical use of DF and recently in DF cured subjects. We monitored by X-band ESR at 163 K, the Fe (III) bound in MHA and transferrin (Tf) in serum from transfused, DF-cured patients. Plotting MHA/Tf versus individual DF dose divided the patients into two subgroups, A and B; A with the two variables correlated linearly and B presenting no correlation. The patients in B presented a higher incidence and severity of clinical complications and lower therapy responsiveness as compared to subjects in A. The ratio MHA/Tf evidenced a quadratic dependence on the mass of transfused erythrocytes (TE) in A, and no regularity in B. Similar patterns appeared in plots of ferritin (FT) and hemoglobin (Hb) vs. DF and TE, but all correlation become visible only after A vs. B discrimination by ESR. The results point to a heavier iron overload in B than in A patients, suggesting different Hb degradation pathways in the two subgroups with more toxic 'free' iron produced in B than in A. Therefore, ESR of serum might serve for improving the precision of diagnosis, for prognosis of dissimilar therapeutic efficiency of DF in patients and for monitoring the long-term efficiency of therapy in homozygous β-thalassemia. (authors)

  4. ESR spectra of organic molecules in triplet state; studies on the structure, internal interaction and the influence of environment

    International Nuclear Information System (INIS)

    Kemp, T.

    1980-01-01

    The origins, features and interpretation of triplet state e.s.r. spectra are described. Examples chosen for discussion include carbenes, nitrenes and excited polyacenes. Newly discovered triplet-state substituted aryl cations are described, the D - parameters of which give information as to mechanism of π-stabilization of these unusual species. (author)

  5. Crystal field effects in the ESR spectra of Dysup(3+), Ersup(3+) and Ybsup(3+) in YPd3

    International Nuclear Information System (INIS)

    Rettori, C.; Weber, E.; Donoso, J.P.; Gandra, F.C.G.; Barberis, G.E.

    1981-01-01

    Low temperature ESR experiments of diluted Dy, Er and Yb in YPd 3 are reported. The host cubic crystal field leaves a GAMMA 7 ground state in the case of Yb 3+ , a GAMMA 7 excited state for Er 3+ and a broad and undefined resonance for Dy 3+ . A comparison with Inelastic Neutron Scattering and Magnetic Susceptibility data is given. (orig.)

  6. A comment upon the use of two criteria in the identification of intrinsic ESR in high T sub c oxides

    Energy Technology Data Exchange (ETDEWEB)

    Deville, A.; Gaillard, B. (Aix-Marseille-3 Univ., 13 - Marseille (FR))

    1990-12-15

    An ESR signal detected in a Bi compound has recently been attributed to the SC phase, arguing that two criteria (value and thermal behaviour of the intensity) were met. We draw attention to the weakness of this argument, recalling a canonical example.

  7. CONTAIN calculations

    International Nuclear Information System (INIS)

    Scholtyssek, W.

    1995-01-01

    In the first phase of a benchmark comparison, the CONTAIN code was used to calculate an assumed EPR accident 'medium-sized leak in the cold leg', especially for the first two days after initiation of the accident. The results for global characteristics compare well with those of FIPLOC, MELCOR and WAVCO calculations, if the same materials data are used as input. However, significant differences show up for local quantities such as flows through leakages. (orig.)

  8. Simultaneous CXCL12 and ESR1 CpG island hypermethylation correlates with poor prognosis in sporadic breast cancer

    International Nuclear Information System (INIS)

    Ramos, Edneia AS; Klassen, Giseli; Camargo, Anamaria A; Braun, Karin; Slowik, Renata; Cavalli, Iglenir J; Ribeiro, Enilze MSF; Pedrosa, Fábio de O; Souza, Emanuel M de; Costa, Fabrício F

    2010-01-01

    CXCL12 is a chemokine that is constitutively expressed in many organs and tissues. CXCL12 promoter hypermethylation has been detected in primary breast tumours and contributes to their metastatic potential. It has been shown that the oestrogen receptor α (ESR1) gene can also be silenced by DNA methylation. In this study, we used methylation-specific PCR (MSP) to analyse the methylation status in two regions of the CXCL12 promoter and ESR1 in tumour cell lines and in primary breast tumour samples, and correlated our results with clinicopathological data. First, we analysed CXCL12 expression in breast tumour cell lines by RT-PCR. We also used 5-aza-2'-deoxycytidine (5-aza-CdR) treatment and DNA bisulphite sequencing to study the promoter methylation for a specific region of CXCL12 in breast tumour cell lines. We evaluated CXCL12 and ESR1 methylation in primary tumour samples by methylation-specific PCR (MSP). Finally, promoter hypermethylation of these genes was analysed using Fisher's exact test and correlated with clinicopathological data using the Chi square test, Kaplan-Meier survival analysis and Cox regression analysis. CXCL12 promoter hypermethylation in the first region (island 2) and second region (island 4) was correlated with lack of expression of the gene in tumour cell lines. In the primary tumours, island 2 was hypermethylated in 14.5% of the samples and island 4 was hypermethylated in 54% of the samples. The ESR1 promoter was hypermethylated in 41% of breast tumour samples. In addition, the levels of ERα protein expression diminished with increased frequency of ESR1 methylation (p < 0.0001). This study also demonstrated that CXCL12 island 4 and ESR1 methylation occur simultaneously at a high frequency (p = 0.0220). This is the first study showing a simultaneous involvement of epigenetic regulation for both CXCL12 and ESR1 genes in Brazilian women. The methylation status of both genes was significantly correlated with histologically advanced

  9. Neutron importance calculation in an equivalent cell using the age approximation and differential thermalization models. Determination of the cross section sensitivity to the parameters of a differential model in the thermal range

    International Nuclear Information System (INIS)

    Sidorenko, V.D.

    1978-01-01

    The equations are discussed for calculating the importance of neutron function in heterogeneous media obtained with the integral transport theory method. The thermalization effect in the thermal range is described using the differential model. The account of neutron slowing-down in the epithermal range is accomplished in the age approximation. The fast range is described in the 3-group approximation. On the basis of the equations derived the share of delayed neutrons and lifetimes of prompt neutrons are calculated and compared with available experimental data. In the thermal range the sensitivity of cross sections to some parameters of the differential model is analyzed for reactor cells typical for WWER type reactor cores. The models and approximations used are found to be adequate for the calculations

  10. ESR of Ag2+ ions in S2F2 crystal

    International Nuclear Information System (INIS)

    Zaripov, M.M.; Ulanov, V.A.; Falin, M.L.

    1989-01-01

    Experimental data on investigation of bivalent silver ions in S 2 F 2 crystals are presented. Due to the investigation of the grown crystals it is determined that centres of univalent silver ore formed in SrF 2 during crystal growth. X-ray irradiation at room temperature results in the transition of these centres in bivalent staes. Investigation of temperature dependence of ESR spectra type has allowed to make the conclusion about the presence of Jahn-Teller dynamic effect. Analysis of experimental data allows to develop a model of the investigated paramagnetic complex in S 2 F 2 crystal where Ag 2* ion has coordination polyhedron in the form of eight F - ion cube distorted by C 3 3 axis

  11. ESR spectra studies on polyterafluoroethyene films irradiated by radio frequency plasmas

    International Nuclear Information System (INIS)

    Ma Yuguang; Yang Meiling; Shen Jiacong; Lin Dehou

    1991-01-01

    The PTFE (polytetrafluoroethylene) films irradiated by Ar plasma were studied by using the method of ESR spectrometer. The peroxide free radicals were found on the surface of PTFE after plasma irradiation, which existed in the layer of some thickness of the surface. These free radicals were quite stable at room temperature. But when density of peroxide free radicals on the PTFE surface was big enough, termination reaction between the peroxide free radicals bound happen and endoperoxides were formed on the PTFE surface. Also the density of peroxide free radical decreased with increasing temperature and underwent a sudden change with temperature reaching 399 K- the glass transition temperature PTFE. The peroxide free radicals can be caught by free radical catcher PBN to form a stable free radical, also can react with MMA to form grafting layer

  12. Detection of prior irradiation in dried fruits by electron spin resonance (ESR)

    International Nuclear Information System (INIS)

    Esteves, M.P.; Andrade, M.E.; Empis, J.

    1998-01-01

    Complete text of publication follows. Dried almonds, raisins, dates and pistachio were irradiated using gamma radiation and electron beam with an average absorbed dose of 5 kGy. The radiation treatment was detected by ESR spectroscopy. Different parts of the dried fruits were analysed as follows: almonds: skin; raisins: dried pulp (at 30 deg C for one week); dates: dried pulp (at 30 deg C for one week) and stone; pistachio: nutshell. A Bruker ECS 106 EPR Spectrometer, at a microwave power of 0.4 mW, at room temperature was used. The analysis were carried out 2-3 months and 6 months after irradiation. A series of signals, tentatively described as 'cellulose-like', 'sugar-like' and 'complex' were observed, and some slight differences between spectra recorded from samples irradiated with gamma and electrons were evident

  13. Detection of prior irradiation in dried fruits by electron spin resonance (ESR)

    Energy Technology Data Exchange (ETDEWEB)

    Esteves, M P [Instituto Nacional de Investigacao Agraria (EAN), Oeiras (Portugal); Andrade, M E [Instituto Tecnologico e Nuclear (ITN), Sacavem (Portugal); Empis, J [Instituto Superior Tecnico (IST), Lisboa (Portugal)

    1999-12-31

    Complete text of publication follows. Dried almonds, raisins, dates and pistachio were irradiated using gamma radiation and electron beam with an average absorbed dose of 5 kGy. The radiation treatment was detected by ESR spectroscopy. Different parts of the dried fruits were analysed as follows: almonds: skin; raisins: dried pulp (at 30 deg C for one week); dates: dried pulp (at 30 deg C for one week) and stone; pistachio: nutshell. A Bruker ECS 106 EPR Spectrometer, at a microwave power of 0.4 mW, at room temperature was used. The analysis were carried out 2-3 months and 6 months after irradiation. A series of signals, tentatively described as `cellulose-like`, `sugar-like` and `complex` were observed, and some slight differences between spectra recorded from samples irradiated with gamma and electrons were evident.

  14. Laser spectroscopy with a cooler ring at the ESR (GSI) and the TSR (MPI Heidelberg)

    International Nuclear Information System (INIS)

    Kuehl, T.; Borneis, S.; Greten, G.; Marx, D.; Neumann, R.; Schroeder, S.; Grieser, R.; Hoog, I.; Huber, G.; Klaft, I.; Klein, R.; Merz, P.; Balykin, V.; Bock, M.; Ellert, C.; Forck, P.; Grieser, M.; Grimm, R.; Habs, D.; Miesner, H.J.; Petrich, W.; Wanner, B.; Becker, C.; Schwalm, D.; Wolf, A.

    1992-01-01

    At the TSR cooler ring at Heidelberg, laser studies were carried out using singly charged lithium and beryllium ions. Laser spectroscopy of relativistic lithium ions (υ = 0.04c) yielded signals with a narrow linewidth, suitable for an experimental test of special relativity. A dramatic reduction of the beam temperature, as defined by the longitudinal velocity spread, was achieved via laser cooling in both cases. At the ion energies available at ESR it will become possible to prepare and store bare ions up to U 92+ . Electron cooling was successfully demonstrated for hydrogen-like Bi 82+ ions, where a laser experiment is scheduled to study the ground-state hyperfine splitting. (orig.)

  15. ESR characterization of point defects in amber colored c-BN super abrasive powders

    International Nuclear Information System (INIS)

    Nistor, S.V.; Ghica, D.; Stefan, M.; Bouwen, A.; Goovaerts, E.

    2004-01-01

    Cubic boron nitride (c-BN) crystalline superabrasive powder (Borazon ** CBN 400), consisting of 200-300 microns sized amber colored crystallites prepared by HP/HT synthesis, has been examined from 2.1 K to 293 K by X-band ESR spectroscopy. The observed spectrum consists of a component line A1, visible in the whole temperature range, and two component lines A2 and A3, visible at high and low temperatures, respectively. The A1 and A3 lines originate from transitions inside S = 1/2 ground states of distinct paramagnetic species and A2 from transitions inside an excited state of another paramagnetic center. The intensity of the A1 and A3 lines changes differently during in situ low temperature illumination in the UV-VIS range. * Borazon is a registered trademark of Diamond Innovations, Inc. (copyright 2004 WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim) (orig.)

  16. The chemistry of Li/SOCl2 cells - An ESR study of carbon electrodes

    Science.gov (United States)

    Kim, S. S.; Carter, B. J.; Tsay, F. D.

    1985-01-01

    Carbon electrodes from Li/SOCl2 cells were studied by electron spin resonance after various stages of discharge. Different behavior was observed in the temperature-dependent part of the ESR linewidth, defined as 'intrinsic linewidth', Delta H(int), when two different electrolytes were used. With one electrolyte, 1.5M LiAlCl4/SoCl2, the Delta H(int) value stayed constant or slightly decreased whereas with another electrolyte, 1.0M LiAlCl4/14 percent BrClin SOCl2, the value increased as discharge progressed. The carbon electrodes are modified differently during discharge with these two electrolytes, and it is speculated that this may be due to changes in the carbon matrix functional groups. This difference in the carbon electrodes may explain the claimed differences in safety performance of the cells.

  17. ESR spectra of the olive phenolics oleuropein and keracyanin in the solid state

    International Nuclear Information System (INIS)

    Hunter, C.R.; Troup, G.J.; Hutton, D.R.; Hewitt, D.J.; Romani, A.; Mulinacci, N.; Vincieri, F.F.

    1998-01-01

    Full text: Olives and extra virgin olive oil, are known to be very rich in antioxidants, most of which are phenolics, such as oleuropein, a derivative of catechol: the 'catechol' ring is separated, and effectively isolated electrically from the other (6-sided) ring. The main anthocyanin in olives in keracyanin (cyanidin-3-0-rutinoside). Solid samples of these two phenolics, and of catechol, were examined by ESR using a Varian E-12 spectrometer (x-band: ∼9.1 GHz) at room temperature. All three samples gave single unstructured lines of ∼ 10g. width with g-vales close to 2. The presence of these free radical signal shows the antioxidant action of these phenolics, even in the solid state. We believe this is first observation of free radicals in olive phenolics

  18. ESR spectra of the olive phenolics oleuropein and keracyanin in the solid state

    Energy Technology Data Exchange (ETDEWEB)

    Hunter, C.R. [Monash University, Clayton, VIC (Australia). Anatomy Department; Troup, G.J.; Hutton, D.R. [Monash University, Clayton, VIC (Australia). Physics Department; Hewitt, D.J. [Monash University, Clayton, VIC (Australia). Chemistry Department; Romani, A.; Mulinacci, N.; Vincieri, F.F. [Universita degli Studi, Firenze (Italy). Dipartimento di Scienze Farmaceutiche

    1998-12-31

    Full text: Olives and extra virgin olive oil, are known to be very rich in antioxidants, most of which are phenolics, such as oleuropein, a derivative of catechol: the `catechol` ring is separated, and effectively isolated electrically from the other (6-sided) ring. The main anthocyanin in olives in keracyanin (cyanidin-3-0-rutinoside). Solid samples of these two phenolics, and of catechol, were examined by ESR using a Varian E-12 spectrometer (x-band: {approx}9.1 GHz) at room temperature. All three samples gave single unstructured lines of {approx} 10g. width with g-vales close to 2. The presence of these free radical signal shows the antioxidant action of these phenolics, even in the solid state. We believe this is first observation of free radicals in olive phenolics

  19. Identification and dose determination using ESR measurements in the flesh of irradiated vegetable products

    International Nuclear Information System (INIS)

    Jesus, E.F.O. de; Rossi, A.M.; Lopes, R.T.

    2000-01-01

    The international commerce of vegetable products is often dependent on the quarantine protections that are imposed by the importing countries because of the fear of contamination by fruit flies. The use of ionizing radiation as a treatment for these products can be used to remove this problem and a real proof of irradiation can contribute to the implementation of the international commerce. ESR measurement on the pulp of vegetable products can be used as a proof of irradiation using the species introduced in cellulose that are found uniquely in irradiated products. The stability of these species are compatible with the life of the products analyzed. The pulp signal intensity is sufficient to identify products irradiated with doses as low as 100 Gy for some fruits

  20. ESR studies of antioxidative activity of different elecampane (Inula helenium L extracts

    Directory of Open Access Journals (Sweden)

    Čanadanović-Brunet Jasna M.

    2002-01-01

    Full Text Available The influence of petroleum ether, ethyl acetate and water extracts of elecampane (lnula helenium L on the transformation of the stable 1,1-diphenyl-2-pycrylhydrazil (DPPH radicals has been investigated by ESR spectroscopy. Using the phytochemist "screening" test a qualitative analysis of extracts has been made. On the basis of the obtained results it can be concluded that the investigated elecampane extracts have the antioxidative activity due to the hydrogen donor ability of the constituent biomolecules such as tannins, terpenes, polyphenols, etc. The following order of antioxidative activity has been established: ethyl acetate > petroleum ether > water extracts. Also, the investigation showed that the antioxidative activity increased with increasing concentration of all the extracts.

  1. Molecular organization and dynamics of micellar phase of polyelectrolyte-surfactant complexes: ESR spin probe study

    Science.gov (United States)

    Wasserman, A. M.; Kasaikin, V. A.; Zakharova, Yu. A.; Aliev, I. I.; Baranovsky, V. Yu.; Doseva, V.; Yasina, L. L.

    2002-04-01

    Molecular dynamics and organization of the micellar phase of complexes of linear polyelectrolytes with ionogenic and non-ionogenic surfactants was studied by the ESR spin probe method. Complexes of polyacrylic acid (PAA) and sodium polystyrenesulfonate (PSS) with alkyltrimethylammonium bromides (ATAB), as well as complexes of poly- N, N'-dimethyldiallylammonium chloride (PDACL) with sodium dodecylsulfate (SDS) were studied. The micellar phase of such complexes is highly organized molecular system, molecular ordering of which near the polymeric chain is much higher than in the 'center' of the micelle, it depends on the polymer-detergent interaction, flexibility of polymeric chain and length of carbonic part of the detergent molecule. Complexes of polymethacrylic acid (PMAA) with non-ionic detergent (dodecyl-substituted polyethyleneglycol), show that the local mobility of surfactant in such complexes is significantly lower than in 'free' micelles and depends on the number of micellar particles participating in formation of complexes.

  2. Intra-albumin migration of bound fatty acid probed by spin label ESR

    International Nuclear Information System (INIS)

    Gurachevsky, Andrey; Shimanovitch, Ekaterina; Gurachevskaya, Tatjana; Muravsky, Vladimir

    2007-01-01

    Conventional ESR spectra of 16-doxyl-stearic acid bound to bovine and human serum albumin were recorded at different temperatures in order to investigate the status of spin-labeled fatty acid in the interior of the protein globule. A computer spectrum simulation of measured spectra, performed by non-linear least-squares fits, clearly showed two components corresponding to strongly and weakly immobilized fatty acid molecules. The two-component model was verified on spectra measured at different pH. Thermodynamic parameters of the spin probe exchange between two spin probe states were analyzed. It was concluded that at physiological conditions, fatty acid molecules permanently migrate in the globule interior between the specific binding sites and a space among albumin domains

  3. The use of sugar pellets in ESR [electron spin resonance] dosimetry

    International Nuclear Information System (INIS)

    Tchen, A.; Greenstock, C.L.; Trivedi, A.

    1993-01-01

    Table sugar (sucrose) is a convenient, common, tissue-equivalent material suitable for electron spin resonance (ESR) dosimetry of ionising radiation. The simple free radical signal in irradiated sugar is stabilised if the sugar is made into pellets using an inert silicone elastomer (Dow Corning 732). Such pellets, which offer greater convenience and signal stability and reproducibility, have been prepared and tested for their radiation response, sensitivity and post-irradiation stability. Irradiated sugar is detectable at ≥0.1 Gy, the signal intensity is linear with dose, and the fading of the signal, post-irradiation, is minimal for samples kept under ambient conditions. These pellets themselves, given sufficient post-irradiation signal stability, may be useful for environmental monitoring to determine long-term exposures in remote areas or at strategic locations. (Author)

  4. ESR investigation of radicals formed in γ-irradiated vinylidene fluoride based copolymer: P(VDF-co-HFP)

    International Nuclear Information System (INIS)

    Dumas, Ludovic; Albela, Belén; Bonneviot, Laurent; Portinha, Daniel; Fleury, Etienne

    2013-01-01

    Samples of copolymer based on vinylidene fluoride and hexafluoropropene P(VDF-co-HFP) were exposed to γ-radiation performed under an inert atmosphere and the total amount of radicals was quantified by electron spin resonance spectroscopy (ESR). An in-depth study of recorded ESR spectra allowed the identification of several types of radical species formed during radiolysis. Starting from an ESR simulation model established for irradiated PVDF, seven radical species have been identified in the case of P(VDF-co-HFP): five of them are related to the VDF units while the two others are derived from the HFP unit. The model used to simulate the complex superimposed ESR signals is presented. The proportions of each species are discussed and correlated to the amount of HFP units contained in the copolymer, and to the stability of each species depending on their local environment. Furthermore, the evolution of radical density with radiation dose and the decay resulting from annealing at a given temperature are presented. Corresponding spectral evolution shows the progressive predominance of most stable species. - Highlights: ► ESR signal of γ-irradiated P(vinylidene fluoride-co-hexafluoropropene) containing 6 wt% of hexafluoropropene is modeled. ► The formation of seven major radical species is proposed for the first time. ► Despite a low comonomer content, 43% of radicals are localized on hexafluoropropene. ► Effect of dose and annealing highlight radical stability. ► Radical stability is found to depend on both chemical environment and chain location

  5. The Arabidopsis KH-Domain RNA-Binding Protein ESR1 Functions in Components of Jasmonate Signalling, Unlinking Growth Restraint and Resistance to Stress.

    Directory of Open Access Journals (Sweden)

    Louise F Thatcher

    Full Text Available Glutathione S-transferases (GSTs play important roles in the protection of cells against toxins and oxidative damage where one Arabidopsis member, GSTF8, has become a commonly used marker gene for early stress and defense responses. A GSTF8 promoter fragment fused to the luciferase reporter gene was used in a forward genetic screen for Arabidopsis mutants with up-regulated GSTF8 promoter activity. This identified the esr1-1 (enhanced stress response 1 mutant which also conferred increased resistance to the fungal pathogen Fusarium oxysporum. Through positional cloning, the ESR1 gene was found to encode a KH-domain containing RNA-binding protein (At5g53060. Whole transcriptome sequencing of esr1-1 identified altered expression of genes involved in responses to biotic and abiotic stimuli, hormone signaling pathways and developmental processes. In particular was an overall significant enrichment for jasmonic acid (JA mediated processes in the esr1-1 down-regulated dataset. A subset of these genes were tested for MeJA inducibility and we found the expression of some but not all were reduced in esr1-1. The esr1-1 mutant was not impaired in other aspects of JA-signalling such as JA- sensitivity or development, suggesting ESR1 functions in specific components of the JA-signaling pathway. Examination of salicylic acid (SA regulated marker genes in esr1-1 showed no increase in basal or SA induced expression suggesting repression of JA-regulated genes is not due to antagonistic SA-JA crosstalk. These results define new roles for KH-domain containing proteins with ESR1 unlinking JA-mediated growth and defense responses.

  6. Pubertal Escape From Estradiol Negative Feedback in Ewe Lambs Is Not Accounted for by Decreased ESR1 mRNA or Protein in Kisspeptin Neurons.

    Science.gov (United States)

    Bedenbaugh, Michelle N; D'Oliveira, Marcella; Cardoso, Rodolfo C; Hileman, Stanley M; Williams, Gary L; Amstalden, Marcel

    2018-01-01

    In this study, we investigated whether decreased sensitivity to estradiol negative feedback is associated with reduced estrogen receptor α (ESR1) expression in kisspeptin neurons as ewe lambs approach puberty. Lambs were ovariectomized and received no implant (OVX) or an implant containing estradiol (OVX+E). In the middle arcuate nucleus (mARC), ESR1 messenger RNA (mRNA) was greater in OVX than OVX+E lambs but did not differ elsewhere. Post hoc analysis of luteinizing hormone (LH) secretion from OVX+E lambs revealed three patterns of LH pulsatility: low [1 to 2 pulses per 12 hours; low frequency (LF), n = 3], moderate [6 to 7 pulses per 12 hours; moderate frequency (MF), n = 6], and high [>10 pulses per 12 hours; high frequency (HF), n = 5]. The percentage of kisspeptin neurons containing ESR1 mRNA in the preoptic area did not differ among HF, MF, or LF groups. However, the percentage of kisspeptin neurons containing ESR1 mRNA in the mARC was greater in HF (57%) than in MF (36%) or LF (27%) lambs and did not differ from OVX (50%) lambs. A higher percentage of kisspeptin neurons contained ESR1 protein in all regions of the arcuate nucleus (ARC) in OVX compared with OVX+E lambs. There were no differences in ESR1 protein among the HF, MF, or LF groups in the preoptic area or ARC. Contrary to our hypothesis, increases in LH pulsatility were associated with enhanced ESR1 mRNA abundance in kisspeptin neurons in the ARC, and absence of estradiol increased the percentage of kisspeptin neurons containing ESR1 protein in the ARC. Therefore, changes in the expression of ESR1, particularly in kisspeptin neurons in the ARC, do not explain the pubertal escape from estradiol negative feedback in ewe lambs. Copyright © 2018 Endocrine Society.

  7. ESR analyses for teeth from the open-air site at Attirampakkam, India: Clues to complex U uptake and paleoenvironmental change

    International Nuclear Information System (INIS)

    Blackwell, Bonnie A.B.; Montoya, Andres; Blickstein, Joel I.B.; Skinner, Anne R.; Pappu, Shanti; Gunnell, Yanni; Taieb, Maurice; Kumar, Akhilesh; Lundberg, Joyce A.

    2007-01-01

    In open-air sites, diagenetic alteration makes teeth difficult to analyze with electron spin resonance (ESR). Despite strong diagenetic alteration, three ungulate teeth from Pleistocene fluvial sediment in the open-air Paleolithic site at Attirampakkam, Tamil Nadu, India, were analyzed using standard and isochron ESR. Diagenetic alteration features in two teeth indicated rapid submergence in quiet saline to hypersaline water, following a short subaerial exposure, while the third remained constantly buried under reducing conditions. Geochemical signatures and ESR data all indicate that the teeth experienced at least three independent U uptake events during diagenesis, including two that occurred long after burial

  8. Test of special relativity theory by means of laser spectroscopy on relativistic {sup 7}Li{sup +} ions in the ESR; Test der Speziellen Relativitaetstheorie mittels Laserspektroskopie an relativistischen {sup 7}Li{sup +}-Ionen am ESR

    Energy Technology Data Exchange (ETDEWEB)

    Botermann, Benjamin

    2012-10-31

    The invariance under Lorentz transformation of the laws of physics is a fundamental postulate of modern physics and all theories of the fundamental interactions have been stated in a covariant form. Although the theory of Special Relativity (SR) has been tested and confirmed with high accuracy in a large number of experiments, improved tests are of fundamental interest due to the far-reaching relevance of this postulate. Additionally modern attempts of a unified description of the four fundamental interactions point to possible violations of Lorentz invariance. In this context experiments of the Ives-Stilwell type for a test of time dilation play an important role. High resolution laser spectroscopy is applied on relativistic particle beams to investigate the validity of the relativistic Doppler formula - and therefore of the time dilation factor γ. In the course of this thesis an Ives-Stilwell experiment was performed with {sup 7}Li{sup +} ions at a velocity of 34 % of the speed of light, which were stored at the experimental storage ring (ESR) of the GSI Helmholtzzentrum fuer Schwerionenforschung. The techniques of Λ- as well as saturation spectroscopy were employed on the 1s2s{sup 3}S{sub 1}→1s2p{sup 3}P{sub 2} transition. By a computer based analysis of the fluorescence detection system and utilization of appropriate edge filters the signal to noise ratio was decisively improved and the application of an additional pump laser allowed for the observation of a saturation signal for the first time. The frequency stability of both laser systems was specified by means of a frequency comb to obtain the highest possible accuracy. The data from the beam times were analyzed in the frameworks of the Robertson-Mansouri-Sexl test theory (RMS) and the Standard Model Extension (SME) and the corresponding upper limits of the relevant test parameters of the assigned theories were calculated. The upper limit of the parameter α was improved by a factor of 4 compared to

  9. Burnout calculation

    International Nuclear Information System (INIS)

    Li, D.

    1980-01-01

    Reviewed is the effect of heat flux of different system parameters on critical density in order to give an initial view on the value of several parameters. A thorough analysis of different equations is carried out to calculate burnout is steam-water flows in uniformly heated tubes, annular, and rectangular channels and rod bundles. Effect of heat flux density distribution and flux twisting on burnout and storage determination according to burnout are commended [ru

  10. Test of special relativity theory by means of laser spectroscopy on relativistic 7Li+ ions in the ESR

    International Nuclear Information System (INIS)

    Botermann, Benjamin

    2012-01-01

    The invariance under Lorentz transformation of the laws of physics is a fundamental postulate of modern physics and all theories of the fundamental interactions have been stated in a covariant form. Although the theory of Special Relativity (SR) has been tested and confirmed with high accuracy in a large number of experiments, improved tests are of fundamental interest due to the far-reaching relevance of this postulate. Additionally modern attempts of a unified description of the four fundamental interactions point to possible violations of Lorentz invariance. In this context experiments of the Ives-Stilwell type for a test of time dilation play an important role. High resolution laser spectroscopy is applied on relativistic particle beams to investigate the validity of the relativistic Doppler formula - and therefore of the time dilation factor γ. In the course of this thesis an Ives-Stilwell experiment was performed with 7 Li + ions at a velocity of 34 % of the speed of light, which were stored at the experimental storage ring (ESR) of the GSI Helmholtzzentrum fuer Schwerionenforschung. The techniques of Λ- as well as saturation spectroscopy were employed on the 1s2s 3 S 1 →1s2p 3 P 2 transition. By a computer based analysis of the fluorescence detection system and utilization of appropriate edge filters the signal to noise ratio was decisively improved and the application of an additional pump laser allowed for the observation of a saturation signal for the first time. The frequency stability of both laser systems was specified by means of a frequency comb to obtain the highest possible accuracy. The data from the beam times were analyzed in the frameworks of the Robertson-Mansouri-Sexl test theory (RMS) and the Standard Model Extension (SME) and the corresponding upper limits of the relevant test parameters of the assigned theories were calculated. The upper limit of the parameter α was improved by a factor of 4 compared to earlier measurements performed

  11. Molecular mechanisms of the direct radiation effects on the DNA: ESR spectroscopy for examining oriented fibres after X-ray exposure

    International Nuclear Information System (INIS)

    Voit, K.

    1986-01-01

    This thesis contains experiments, investigating molecular interactions between X radiation and DNA. ESR-spectra of the primary radicals are simulated. The types of secondary radicals are described. (AJ) [de

  12. Irradiation dose control of chicken meat processing with alanine/ESR dosimetric system

    International Nuclear Information System (INIS)

    Miyagusku, L.; Chen, F.; Kuaye, A.; Castilho, C.J.C.; Baffa, O.

    2007-01-01

    Irradiation of foodstuff is a well-known food preservation technique. In Brazil spices are already irradiated for sanitary and preservation reasons. Chicken meat is an important commodity; Brazil is the second largest world producer and the largest world exporter. The shelf-life of chicken meat is limited by the presence of micro-organisms and enzyme activity and together with other preservation techniques irradiation seems to be an attractive option. In this study the dose delivered to frozen chicken cuts was measured and compared with the prescribed value. Chicken breast cuts were analyzed for 39 days for their microbiological activity, chemical and organoleptic properties. Cylindrical dosimeters were prepared using the weight composition of 80% of DL-alanine (Sigma Co), used without any further treatment except drying, and 20% of paraffin. The dosimeters having 4.7 mm diameter and 12 mm length were inserted in a build-up cap. Dosimeters were placed inside cardboard boxes containing frozen chicken breast cuts, packed in styrofoam trays wrapped with plastic film. The boxes were irradiated in an industrial 60 Co irradiator (Nordion JS 7500) with a dose rate of 4 kGy/h. First derivative ESR signals were obtained in a VARIAN E-4 spectrometer operating at X-band (ν∼9GHz) and equipped with a rectangular cavity (TE-102, model E-231). The cavity was constantly purged with dry nitrogen and modulated at 100 KHz with 0.5 mT peak to peak. A calibration curve was made for a few dosimeters from the same batch and used to obtain the dose from the ESR signal intensity. A batch of six boxes was irradiated at each experiment with prescribed doses of 1.5, 3.0 and 7.0 kGy. Considering that the larger the radiation dose the greater is the probability of finding a product with its sensorial characteristics altered (odor of burned meat), we conclude that a dose of 3 kGy would be more adequate, taking into account the microbiological and sensorial aspects

  13. Observation of ESR spin flip satellite lines of trapped hydrogen atoms in solid H2 at 4.2 K

    International Nuclear Information System (INIS)

    Miyazaki, Tetsuo; Iwata, Nobuchika; Fueki, Kenji; Hase, Hirotomo

    1990-01-01

    ESR spectra of H atoms, produced in γ-irradiated solid H 2 , were studied at 4.2 K. Two main lines of the ESR spectra of H atoms that are separated by about 500 G accompanied two weak satellite lines. Both satellite lines and main lines decrease with the same decay rate. In the D 2 -H 2 mixtures, the satellite-line intensity depends upon the number of matrix protons. The spacing of the satellites from the main lines is equal to that of the NMR proton resonance frequency. It was concluded that the satellite lines were not ascribable to paired atoms but to spin flip lines due to an interaction of H atoms with matrix protons. The analysis of the spin flip lines and the main lines suggests that H atoms in solid H 2 are trapped in the substitutional site

  14. Esrâr Dede Divanı’nda Renkler Colours In Dıvan Of Esrâr Dede

    Directory of Open Access Journals (Sweden)

    Mahmut KAPLAN

    2013-03-01

    Full Text Available Esrâr Dede is one of significant figures of our classical poetry. After becoming affiliated with Mevleviyeh, he embarked upon poetry, bringing forth remarkable works. He made friends with Şeyh Galib. The poet has a collection of biographies and dictionary as well as a divan. Esrar Dede frequently used words which expressed colours in order toexplain his feelings and thoughts. The words of colours are alsoimportant bearers of cultural heritage. Colours which are used indescription and definition of entities gain representative meanings insome texts (of the society, too. It is known that some colours statedirections in Turkish. At times, colours are used to express feelings;they reflect people’s mood. Colours are the most important means poetshave to depict sceneries of nature. A poet displays the nature throughwords of colour, and expresses their feelings and thoughts withinsymbolic expressions by means of colours. In depictions made in prosesof eulogiums, colours have important roles. Esrar Dede, most of whoseodes are affectionate, also applied adjectives of colour to express hisfeelings and thoughts. Black and red are especially seen aspredominant colours in Esrar Dede Divan. These colours were used todepict entities and express some sufistic situations. Black is generallyseen in the descriptions of night, hair, and darkness. Moreover, thiscolour is applied to depict situations such as bad fortune andmischance. Red is seen in depictions of rose, dawn, blood, and lips.Except these two main colours, white, yellow, green; andcolournessness and lack of colour which express sufistic situations tookplace among the colours the poet used. When it is taken into accountthat Esrar Dede was a Mevlevi, it will be understood how importantcolours are in his poetry. In this article, Esrar Dede’s perception ofcolour was tried to determine by evaluating the colours he used withintheir contexts in the text. The colours have been arranged andinvestigated in

  15. Aging of SRC liquids

    Science.gov (United States)

    Hara, T.; Jones, L.; Tewari, K. C.; Li, N. C.

    1981-02-01

    The viscosity of SRC-LL liquid increases when subjected to accelerated aging by bubbling oxygen in the presence of copper strip at 62°C. Precipitates are formed and can be separated from the aged liquid by Soxhlet extraction with pentane. A 30-70 blend of SRC-I with SRC-LL was subjected to oxygen aging in the absence of copper, and the viscosity increased dramatically after 6 days at 62°. The content of preasphaltene and its molecular size increase with time of aging, accompanied by decrease of asphaltene and pentane-soluble contents. For the preasphaltene fraction on aging, gel permeation chromatography shows formation of larger particles. ESR experiments show that with oxygen aging, spin concentration in the preasphaltene fraction decreases. Perhaps some semiquinone, together with di- and tri-substituted phenoxy radicals, generated by oxygen aging of the coal liquid, interact with the free radicals already present in coal to yield larger particles and reduce free radical concentration. We are currently using the very high-field (600-MHz) NMR spectrometer at Mellon Institute to determine changes in structural parameters before and after aging of SRC-II and its chromatographically separated fractions.

  16. ESR study of /sup 99/Tc(II) complex formed by reduction of ammonium pertechnetate with ascorbic acid in concentrated hydrochloric acid

    Energy Technology Data Exchange (ETDEWEB)

    Kudo, T; Tsuchihashi, N; Ogata, T

    1987-07-30

    Paramagnetic /sup 99/Tc complex formed by the reduction of ammonium pertechnetate by ascorbic acid with excess sodium nitrite in concentrated hydrochloric acid was investigated by ESR technique. This complex had total electron spin S=1/2 and the obtained ESR parameters are 2.032, 2.043; and 264, 108 gauss, respectively. It was concluded that the formed species was low spin /sup 99/Tc(II) complex. (author) 13 refs.

  17. Reliability calculations

    International Nuclear Information System (INIS)

    Petersen, K.E.

    1986-03-01

    Risk and reliability analysis is increasingly being used in evaluations of plant safety and plant reliability. The analysis can be performed either during the design process or during the operation time, with the purpose to improve the safety or the reliability. Due to plant complexity and safety and availability requirements, sophisticated tools, which are flexible and efficient, are needed. Such tools have been developed in the last 20 years and they have to be continuously refined to meet the growing requirements. Two different areas of application were analysed. In structural reliability probabilistic approaches have been introduced in some cases for the calculation of the reliability of structures or components. A new computer program has been developed based upon numerical integration in several variables. In systems reliability Monte Carlo simulation programs are used especially in analysis of very complex systems. In order to increase the applicability of the programs variance reduction techniques can be applied to speed up the calculation process. Variance reduction techniques have been studied and procedures for implementation of importance sampling are suggested. (author)

  18. Calculator calculus

    CERN Document Server

    McCarty, George

    1982-01-01

    How THIS BOOK DIFFERS This book is about the calculus. What distinguishes it, however, from other books is that it uses the pocket calculator to illustrate the theory. A computation that requires hours of labor when done by hand with tables is quite inappropriate as an example or exercise in a beginning calculus course. But that same computation can become a delicate illustration of the theory when the student does it in seconds on his calculator. t Furthermore, the student's own personal involvement and easy accomplishment give hi~ reassurance and en­ couragement. The machine is like a microscope, and its magnification is a hundred millionfold. We shall be interested in limits, and no stage of numerical approximation proves anything about the limit. However, the derivative of fex) = 67.SgX, for instance, acquires real meaning when a student first appreciates its values as numbers, as limits of 10 100 1000 t A quick example is 1.1 , 1.01 , 1.001 , •••• Another example is t = 0.1, 0.01, in the functio...

  19. Radiochemical aging of an epoxy network; Vieillissement radiochimique d'un reseau epoxyde

    Energy Technology Data Exchange (ETDEWEB)

    Devanne, Th

    2003-05-01

    This thesis is to give a better understanding of the radiochemical aging of a thermoset resin under gamma irradiation. The conditions of aging are gamma irradiation under air with a dose rate of 2 kGy/h at 120 C. The requested lifetime is four years, it means a dose of 70 MGy. The first step of this work was the choice of a resistive epoxy resin. This choice was made thanks to the literature data. The high glass transition temperature and the high amount of aromatic groups were the main criteria of the final choice. After this choice, thermal and mechanical properties were followed under thermal and radiochemical aging: i) under thermal aging, after 600 hours at 220 C, the glass transition temperature remained unchanged. But, from a mechanical point of view, properties at break dramatically decreased. This embrittlement was assigned to a critical oxidized layer. The thickness of this layer was estimated about 30 {mu}m. ii) the same kind of embrittlement was observed under radiochemical aging. Moreover, it appeared a decrease of the glass transition temperature when increasing the dose of irradiation. This indicates that the main degradation mechanism is chain scission under anaerobic atmosphere. We, then, proposed a mechanistic model associated with a kinetic model to predict the evolution of the glass transition temperature depending on the irradiation conditions. Parameters of the kinetic model were determined by solid NMR and ESR experiments. Comparison between experimental and calculated values at 120 C is satisfactory, a global good agreement was found. (author)

  20. Estimation of radiation exposed area by the nuclear accident occurred at Tokai village using ESR measurements of household sugar

    International Nuclear Information System (INIS)

    Kuzuya, Masayuki; Kondo, Shinichi; Ito, Kousuke; Sawa, Takashi

    2001-01-01

    The area of radiation exposure by the nuclear accident occurred at Tokai village in 1999 was estimated by the ESR measurement of 95 household sugar samples collected from the accident area. These samples were roughly classified into three types of sugar, fine white sugar, fine brown sugar and coarse brown sugar. The control fine white sugar showed no radical in the ESR spectrum, while those of fine brown sugar and coarse brown sugar showed the presence of a small amount of radicals. It was also shown that, among these three kinds of sugar, the radical concentration of fine white sugar sampled from wooden houses at the area similar to each other did not vary much with the samples, while those of fine brown sugar and coarse brown sugar varied to a considerable extent. Thus, the fine white sugar is considered to be more suitable for the estimation of the level of radiation exposure. The radical concentration of each fine white sugar sample was plotted against the distance from the site of the nuclear accident with a correction of the difference in the shielding effect between concrete houses and wooden houses. The samples obtained at more than 2 km north of the site of nuclear accident showed no ESR spectral signal to a detectable extent. On the other hand, the ESR spectra were observed from the samples obtained within 10 km south and 4 km west of the accident site. These results suggest that the radiation exposure by the contaminant blown by the northeast wind blowing on the day of the accident may occur at the south and west areas. (author)

  1. ESR and ENDOR of free radicals in γ-irradiated single crystals of trimethoprim at room temperature

    International Nuclear Information System (INIS)

    Krzyminiewski, R.; Kawacka, U.; Pietrzak, J.; Erickson, R.; Lund, A.

    1995-01-01

    Singe crystals of trimethoprim were examined after γ-irradiation at room temperature by ESR and ENDOR spectroscopy. A radicals is formed by abstraction of a hydrogen atom from the CH 2 group of the bridge. The unpaired electron is delocalized mainly onto the trimethoxybenzyl ring. It interacts with one proton of the bridge and with two protons in the trimethoxybenzyl ring. (au) (14 refs.)

  2. The influence of the mould cooling temperature on the surface appearance and the internal quality of ESR ingots

    Science.gov (United States)

    Kubin, M.; Ofner, B.; Holzgruber, H.; Schneider, R.; Enzenhofer, D.; Filzwieser, A.; Konetschnik, S.

    2016-07-01

    One of the main benefits of the ESR process is to obtain an ingot surface which is smooth and allows a subsequent forging operation without any surface dressing. The main influencing factor on surface quality is the precise controlling of the process such as melt rate and electrode immersion depth. However, the relatively strong cooling effect of water as a cooling medium can result in the solidification of the meniscus of the liquid steel on the boundary liquid steel and slag which is most likely the origin of surface defects. The usage of different cooling media like ionic liquids, a salt solution which can be heated up to 250°C operating temperature might diminish the meniscus solidification phenomenon. This paper shows the first results of the usage of an ionic liquid as a mould cooling medium. In doing so, 210mm diameter ESR ingots were produced with the laboratory scale ESR furnace at the university of applied science using an ionic liquid cooling device developed by the company METTOP. For each trial melt different inlet and outlet temperatures of the ionic liquid were chosen and the impact on the surface appearance and internal quality were analyzed. Furthermore the influence on the energy balance is also briefly highlighted. Ultimately, an effect of the usage of ionic liquids as a cooling medium could be determined and these results will be described in detail within the scope of this paper.

  3. Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Jebaraj, D. David [Department of Physics, The American College, Madurai-625 002, Tamilnadu (India); Utsumi, Hideo [Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka 812-8582 (Japan); Asath, R. Mohamed; Benial, A. Milton Franklin, E-mail: miltonfranklin@yahoo.com [Department of Physics, NMSSVN College, Madurai-625 019, Tamilnadu (India)

    2016-05-23

    Electron spin resonance (ESR) studies were carried out for 2mM {sup 14}N labeled {sup 2}H enriched 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) and 3–carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of corn oil. The ESR parameters, such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The line width broadening was observed for both nitroxyl radicals in corn oil solutions. The partition parameter for permeable MC-PROXYL in corn oil increases with increasing concentration of corn oil, which reveals that the nitroxyl spin probe permeates into the oil phase. From the results, the corn oil concentration was optimized as 50 % for phantom studies. The rotational correlation time also increases with increasing concentration of corn oil. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. These results will be useful for the development of ESR/OMR imaging modalities in in vivo and in vitro studies.

  4. ESR and X-ray diffraction studies on thin films of poly-3-hexylthiophene: Molecular orientation and magnetic interactions

    International Nuclear Information System (INIS)

    Sugiyama, Keisuke; Kojima, Takashi; Fukuda, Hisashi; Yashiro, Hisashi; Matsuura, Toshihiko; Shimoyama, Yuhei

    2008-01-01

    Poly-3-hexylthiophene (P3HT) thin films were investigated by X-ray diffraction (XRD) and electron spin resonance (ESR) to reveal the film structure and molecular organization. The XRD data showed a diffraction pattern with a plane separation between the planes containing thiophene rings of 16.0 A. Comparison between the XRD patterns of powder and thin films of P3HT suggests that the main chains are folded on the substrate. Angular variation of the line position (g-value) of ESR spectra revealed that thiophene ring of P3HT orients along the substrate normal axis. The ESR linewidth varied by the angular rotation, indicating the one-dimensional spin-chain interactions in the P3HT thin films with a linear network of spin-chains. An organic thin-film transistor (OTFT) with P3HT film as a channel layer was then demonstrated. The P3HT films showed conducting characteristics with holes as carriers. The OTFTs indicated a field-effect mobility of 4.93 x 10 -3 cm 2 /Vs and an on/off ratio of 73 in the accumulation mode

  5. Permeability studies of redox-sensitive nitroxyl spin probes in corn oil using an L-band ESR spectrometer

    International Nuclear Information System (INIS)

    Jebaraj, D. David; Utsumi, Hideo; Asath, R. Mohamed; Benial, A. Milton Franklin

    2016-01-01

    Electron spin resonance (ESR) studies were carried out for 2mM 14 N labeled 2 H enriched 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl (MC-PROXYL) and 3–carboxy-2,2,5,5,-tetramethyl-1-pyrrolidinyloxy (carboxy-PROXYL) in pure water and various concentrations of corn oil. The ESR parameters, such as the line width, hyperfine coupling constant, g-factor, rotational correlation time, partition parameter and permeability were reported for the samples. The line width broadening was observed for both nitroxyl radicals in corn oil solutions. The partition parameter for permeable MC-PROXYL in corn oil increases with increasing concentration of corn oil, which reveals that the nitroxyl spin probe permeates into the oil phase. From the results, the corn oil concentration was optimized as 50 % for phantom studies. The rotational correlation time also increases with increasing concentration of corn oil. The permeable and impermeable nature of nitroxyl spin probes was demonstrated. These results will be useful for the development of ESR/OMR imaging modalities in in vivo and in vitro studies.

  6. Effect of Low Nickel Dopant on Torque Transducer Response Function in High-Chromium Content ESR Stainless Tool Steels

    Science.gov (United States)

    Wiewel, Joseph L.; Hecox, Bryan G.; Orris, Jason T.; Boley, Mark S.

    2007-03-01

    The change in magnetoelastic torque transducer response was investigated as a low nickel content (up to 0.2%) is alloyed into an ESR (Electro-Slag-Refining) stainless tool steel with a chromium content of around 13%, which our previous studies have proven to be the ideal level of chromium content for optimal transducer performance. Two separate hollow steel 3/4-inch diameter shafts were prepared from ESR 416 and ESR 420 steel, respectively, the first having no nickel content and the second having 0.2% nickel content. The heat treatment of these steels consisted of a hardening process conducted in a helium atmosphere at 1038^oC, followed by an annealing at 871^oC for 5h and a 15^oC cool down rate. Prior and subsequent to the heat treatment processes, the circumferential and axial magnetic hysteresis properties of the samples were measured and their external field signals were mapped over the magnetically polarized regions both with and without applied shear stress up to 2500 psi on the samples. It was found that the effect of the low nickel dopant was to improve torque transducer sensitivity and linearity, but heat treatment worsened the performance of both samples.

  7. Reliability Calculations

    DEFF Research Database (Denmark)

    Petersen, Kurt Erling

    1986-01-01

    Risk and reliability analysis is increasingly being used in evaluations of plant safety and plant reliability. The analysis can be performed either during the design process or during the operation time, with the purpose to improve the safety or the reliability. Due to plant complexity and safety...... and availability requirements, sophisticated tools, which are flexible and efficient, are needed. Such tools have been developed in the last 20 years and they have to be continuously refined to meet the growing requirements. Two different areas of application were analysed. In structural reliability probabilistic...... approaches have been introduced in some cases for the calculation of the reliability of structures or components. A new computer program has been developed based upon numerical integration in several variables. In systems reliability Monte Carlo simulation programs are used especially in analysis of very...

  8. ESR study into mechanism of heterogeneous-catalytic oxidation on oxides

    Energy Technology Data Exchange (ETDEWEB)

    Topchieva, K V; Loginov, A Yu; Kostikov, S V [Moskovskij Gosudarstvennyj Univ. (USSR)

    1977-12-11

    The role of radical particles in heterogeneous-catalytic oxidation of H/sub 2/; CO; SO/sub 2/; NH/sub 3/; C/sub 3/H/sub 6/ on the rare earth oxides (yttrium, lanthanum, magnesium and scandium oxides) and alkaline earth metal oxides was studied by the ESR method. The conclusion was made about the great reactivity of the peroxide structures O/sub 2//sup -/ in the oxidation catalysis in comparison to other formulas of chemisorption oxigen on oxides. The kinetic investigations are chemisorption oxigen on oxides. The kinetic investigations are carried out on the change of the concentration of paramagnetic particles O/sub 2/ during the catalysis. On the basis of the received data the conclusion is made about the reaction process of catalytic oxidation on rare and alkaline-earth oxides according to radical-chain mechanism with the formation of radical particles O/sub 2//sup -/, CO/sub 3//sup -/, SO/sub 4//sup -/, CO/sub 2//sup -/ as interediate products.

  9. Detection of irradiation treatment in crustacea by electron spin resonance (ESR) spectroscopy

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, E.M. [Queen`s Univ., Belfast, Northern Ireland (United Kingdom). Dept. of Food Science; Stevenson, M.H. [Queen`s Univ., Belfast, Northern Ireland (United Kingdom). Dept. of Food Science]|[Department of Agriculture for Northern Ireland, Belfast (United Kingdom); Gray, R. [Department of Agriculture for Northern Ireland, Belfast (United Kingdom)

    1996-12-31

    When the Food (Control of Irradiation) Regulations 1990 came into force in the United Kingdom in January 1991 they included provision for the irradiation of Crustacea to an overall average dose of 3 kGy. The treatment of Crustacea with ionising radiation would reduce numbers of potential pathogens and spoilage organisms thus giving a microbiologically safer product with a longer shelf-life at chill temperatures. At present the process is being used in countries such as France and The Netherlands for the decontamination/shelf-life extension of shrimp. Therefore, as for other food products such as poultry, liquid whole egg and fruit, which are also treated with ionising radiation, it is desirable that a suitable test should be available to help in the control of the irradiation process. One such detection method which has been applied to irradiated Crustacea is that of electron spin resonance (ESR) spectroscopy due to the fact that the rigid exoskeleton has a relatively high dry matter so free radicals produced by ionising irradiation can be trapped and are, therefore, sufficiently stable to be detected. (author).

  10. Detection of irradiation treatment in crustacea by electron spin resonance (ESR) spectroscopy

    International Nuclear Information System (INIS)

    Stewart, E.M.; Gray, R.

    1996-01-01

    When the Food (Control of Irradiation) Regulations 1990 came into force in the United Kingdom in January 1991 they included provision for the irradiation of Crustacea to an overall average dose of 3 kGy. The treatment of Crustacea with ionising radiation would reduce numbers of potential pathogens and spoilage organisms thus giving a microbiologically safer product with a longer shelf-life at chill temperatures. At present the process is being used in countries such as France and The Netherlands for the decontamination/shelf-life extension of shrimp. Therefore, as for other food products such as poultry, liquid whole egg and fruit, which are also treated with ionising radiation, it is desirable that a suitable test should be available to help in the control of the irradiation process. One such detection method which has been applied to irradiated Crustacea is that of electron spin resonance (ESR) spectroscopy due to the fact that the rigid exoskeleton has a relatively high dry matter so free radicals produced by ionising irradiation can be trapped and are, therefore, sufficiently stable to be detected. (author)

  11. Electron spin resonance (ESR dose measurement in bone of Hiroshima A-bomb victim.

    Directory of Open Access Journals (Sweden)

    Angela Kinoshita

    Full Text Available Explosion of the bombs in Hiroshima and Nagasaki corresponds to the only historical moment when atomic bombs were used against civilians. This event triggered countless investigations into the effects and dosimetry of ionizing radiation. However, none of the investigations has used the victims' bones as dosimeter. Here, we assess samples of bones obtained from fatal victims of the explosion by Electron Spin Resonance (ESR. In 1973, one of the authors of the present study (SM traveled to Japan and conducted a preliminary experiment on the victims' bone samples. The idea was to use the paramagnetism induced in bone after irradiation to measure the radiation dose. Technological advances involved in the construction of spectrometers, better knowledge of the paramagnetic center, and improvement in signal processing techniques have allowed us to resume the investigation. We obtained a reconstructed dose of 9.46 ± 3.4 Gy from the jawbone, which was compatible with the dose distribution in different locations as measured in non-biological materials such as wall bricks and roof tiles.

  12. ESR investigation of NR and IR rubber vulcanized with different cross-link agents

    Directory of Open Access Journals (Sweden)

    P. Posadas

    2016-01-01

    Full Text Available This study evaluates the formation of radical species in natural rubber (NR and poly-isoprene rubber (IR during the vulcanization process and the uniaxial deformation of the formed networks by means of Electron Spin Resonance (ESR. Vulcanization of NR and IR always shows a radical pathway, where the different vulcanization systems dictate the concentration of radical species in the course of this complex process. The greatest concentration of radicals were detected during the vulcanization with sulfur/accelerator based on efficient systems (EV, followed by conventional (CV and sulfur donor systems, whereas azide and organic peroxide agents showed smaller concentration of radicals. Independently of the vulcanization system, certain amount of radicals was detected on the vulcanized samples after the end of the vulcanization process. Comparison between different matrices demonstrates that NR always shows higher concentration of radicals than IR in the vulcanization process as well as during uniaxial deformation, fact that could be associated to the presence of nonrubber components in NR.

  13. ENDOR/ESR of Mn atoms and MnH molecules in solid argon

    Science.gov (United States)

    van Zee, R. J.; Garland, D. A.; Weltner, W., Jr.

    1986-09-01

    Mn atoms and MnH molecules, the latter formed by reaction between metal and hydrogen atoms, were trapped in solid argon and their ESR/ENDOR spectra measured at 4 K. At each pumping magnetic field two ENDOR lines were observed for 55Mn(I=5/2) atoms, corresponding to hyperfine transitions within the MS =±1/2 levels. Values of the hyperfine interaction constant and nuclear moment of 55Mn were derived from the six sets of data. For MnH, three sets of signals were detected: a proton ``matrix ENDOR'' line, transitions in the MS =0,±1 levels involving MI (55Mn)=1/2, 3/2, 5/2 levels, and proton transitions corresponding to νH and νH±aH. Analysis yielded the hyperfine constant aH =6.8(1) MHz and the nuclear quadrupole coupling constant Q'(55Mn)=-11.81(2) MHz. The latter compared favorably with a theoretical value derived earlier by Bagus and Schaefer. A higher term in the spin Hamiltonian appeared to be necessary to fit the proton hyperfine data.

  14. ESR Experiments on a Single Donor Electron in Isotopically Enriched Silicon

    Science.gov (United States)

    Tracy, Lisa; Luhman, Dwight; Carr, Stephen; Borchardt, John; Bishop, Nathaniel; Ten Eyck, Gregory; Pluym, Tammy; Wendt, Joel; Witzel, Wayne; Blume-Kohout, Robin; Nielsen, Erik; Lilly, Michael; Carroll, Malcolm

    In this talk we will discuss electron spin resonance experiments in single donor silicon qubit devices fabricated at Sandia National Labs. A self-aligned device structure consisting of a polysilicon gate SET located adjacent to the donor is used for donor electron spin readout. Using a cryogenic HEMT amplifier next to the silicon device, we demonstrate spin readout at 100 kHz bandwidth and Rabi oscillations with 0.96 visibility. Electron spin resonance measurements on these devices show a linewidth of 30 kHz and coherence times T2* = 10 us and T2 = 0.3 ms. We also discuss estimates of the fidelity of our donor electron spin qubit measurements using gate set tomography. This work was performed, in part, at the Center for Integrated Nanotechnologies, a U.S. DOE Office of Basic Energy Sciences user facility. Sandia National Laboratories is a multi-program laboratory operated by Sandia Corporation, a Lockheed-Martin Company, for the U. S. Department of Energy under Contract No. DE-AC04-94AL85000. ESR Experiments on a Single Donor Electron in Isotopically Enriched Silicon.

  15. ROS evaluation for a series of CNTs and their derivatives using an ESR method with DMPO

    International Nuclear Information System (INIS)

    Tsuruoka, S; Noguchi, T; Endo, M; Tristan, F; Terrones, M; Takeuchi, K; Koyama, K; Usui, Y; Matsumoto, H; Saito, N; Porter, D W; Castranova, V

    2013-01-01

    Carbon nanotubes (CNTs) are important materials in advanced industries. It is a concern that pulmonary exposure to CNTs may induce carcinogenic responses. It has been recently reported that CNTs scavenge ROS though non-carbon fibers generate ROS. A comprehensive evaluation of ROS scavenging using various kinds of CNTs has not been demonstrated well. The present work specifically investigates ROS scavenging capabilities with a series of CNTs and their derivatives that were physically treated, and with the number of commercially available CNTs. CNT concentrations were controlled at 0.2 through 0.6 wt%. The ROS scavenging rate was measured by ESR with DMPO. Interestingly, the ROS scavenging rate was not only influenced by physical treatments, but was also dependent on individual manufacturing methods. Ratio of CNTs to DMPO/ hydrogen peroxide is a key parameter to obtain appropriate ROS quenching results for comparison of CNTs. The present results suggest that dangling bonds are not a sole factor for scavenging, and electron transfer on the CNT surface is not clearly determined to be the sole mechanism to explain ROS scavenging.

  16. Frequency dependent power fluctuations: a feature of the ESR system or physical?

    Directory of Open Access Journals (Sweden)

    Y. Ogawa

    Full Text Available The k-dependence of the received power in high signal-to-noise ratio (SNR conditions, occurring for naturally enhanced ion-acoustic lines (NEIALs and for real satellites, is investigated by using the EISCAT Svalbard Radar (ESR, where the data are recorded in eight separate channels using different frequencies. For the real satellites we find large variations of the relative powers from event to event, which is probably due to a different number of pulses catching the satellite over the integration period. However, the large power difference remains unexpected in one case. Over short time scale (< 10 s the relative power difference seems to be highly stable. For most NEIAL events the differences between channels are within noise level. In a few cases variations of the relative power well above both the estimated and expected 1-sigma level occur over a signal preintegrated profile. We thus suggest that the frequency dependence of the power in NEIAL events has its origin in the scattering medium itself as the most plausible explanation.

    Key words: Ionosphere (auroral ionosphere; plasma waves and instabilities; instruments and techniques

  17. Frequency dependent power fluctuations: a feature of the ESR system or physical?

    Directory of Open Access Journals (Sweden)

    Y. Ogawa

    2000-09-01

    Full Text Available The k-dependence of the received power in high signal-to-noise ratio (SNR conditions, occurring for naturally enhanced ion-acoustic lines (NEIALs and for real satellites, is investigated by using the EISCAT Svalbard Radar (ESR, where the data are recorded in eight separate channels using different frequencies. For the real satellites we find large variations of the relative powers from event to event, which is probably due to a different number of pulses catching the satellite over the integration period. However, the large power difference remains unexpected in one case. Over short time scale (< 10 s the relative power difference seems to be highly stable. For most NEIAL events the differences between channels are within noise level. In a few cases variations of the relative power well above both the estimated and expected 1-sigma level occur over a signal preintegrated profile. We thus suggest that the frequency dependence of the power in NEIAL events has its origin in the scattering medium itself as the most plausible explanation.Key words: Ionosphere (auroral ionosphere; plasma waves and instabilities; instruments and techniques

  18. ESR detection of free radicals in polyphenolic extracts from wine grapes, olives and green tea

    International Nuclear Information System (INIS)

    Troup, G.J.; Hutton, D.R.; Romani, A.; Mulinacci, N.; Vincieri, F.F.; Hunter, C.R.; Hewitt, D.G.

    1998-01-01

    Full text: Polyphenols are widespread in vegetables and fruits and they play an important role in human diet and health: these compounds act mainly as antioxidants and radical scavengers. In this work we have detected free radicals in the following natural polyphenols: Endotelon, an anthocyanic grapeskin extract; malvidin 3,5-O-diglucosides (malvin); oleuropein, an olive polyphenol; a commercial green tea extract, and pure epigallocatechingallate EGCG. The investigation was performed using a Varian E-12 ESR Spectrometer (∼9.1 GHz) at room temperature. All except the green tea extract gave single unstructured lines of ∼ 10 gauss linewidth. The tea extract signal showed 3 lines, one ∼ 20 gauss wide, one ∼ 10 gauss wide, and one ∼ 2-3 gauss wide. Saturation behaviour of these lines at room and liquid N 2 temperature showed them to be from different radicals About 50% of the extract is represented by epigallocatechingallate (EGCG). Using the pure sample EGCG it was possible to assign the appropriate radical, which corresponded with the broadest and strongest 'single' signal (∼20g wide). The presence of the free radicals in the solid extracts shows that the appropriate molecules can act as radical scavengers by forming stable radicals

  19. ROS evaluation for a series of CNTs and their derivatives using an ESR method with DMPO.

    Science.gov (United States)

    Tsuruoka, S; Takeuchi, K; Koyama, K; Noguchi, T; Endo, M; Tristan, F; Terrones, M; Matsumoto, H; Saito, N; Usui, Y; Porter, D W; Castranova, V

    Carbon nanotubes (CNTs) are important materials in advanced industries. It is a concern that pulmonary exposure to CNTs may induce carcinogenic responses. It has been recently reported that CNTs scavenge ROS though non-carbon fibers generate ROS. A comprehensive evaluation of ROS scavenging using various kinds of CNTs has not been demonstrated well. The present work specifically investigates ROS scavenging capabilities with a series of CNTs and their derivatives that were physically treated, and with the number of commercially available CNTs. CNT concentrations were controlled at 0.2 through 0.6 wt%. The ROS scavenging rate was measured by ESR with DMPO. Interestingly, the ROS scavenging rate was not only influenced by physical treatments, but was also dependent on individual manufacturing methods. Ratio of CNTs to DMPO/ hydrogen peroxide is a key parameter to obtain appropriate ROS quenching results for comparison of CNTs. The present results suggest that dangling bonds are not a sole factor for scavenging, and electron transfer on the CNT surface is not clearly determined to be the sole mechanism to explain ROS scavenging.

  20. Simultaneous high- and low-latitude reconnection: ESR and DMSP observations

    Directory of Open Access Journals (Sweden)

    F. Pitout

    2002-09-01

    Full Text Available We present EISCAT Svalbard Radar and DMSP observations of a double cusp during an interval of predominantly northward IMF on 26 November 2000. In the cusp region, the ESR dish, pointing northward, recorded sun-ward ionospheric flow at high latitudes (above 82° GL, indicating reconnection occuring in the magnetospheric lobe. Meanwhile, the same dish also recorded bursts of poleward flow, indicative of bursty reconnection at the subsolar magnetopause. Within this time interval, the DMSP F13 satellite passed in the close vicinity of the Svalbard archipelago. The particle measurement on board exhibited a double cusp structure in which two oppositely oriented ion dispersions are recorded. We interpret this set of data in terms of simultaneous merging at low- and high-latitude magnetopause. We discuss the conditions for which such simultaneous high-latitude and low-latitude reconnection can be anticipated. We also discuss the consequences of the presence of two X-lines in the dayside polar ionosphere.Key words. Magnetospheric physics (solar wind-magnetosphere interactions – Ionosphere (polar ionosphere; plasma convection

  1. The characteristics of ESR and 3-D TL spectra of diamonds

    International Nuclear Information System (INIS)

    Liu Shunsheng; Lu Xu; Fu Huifang

    2003-01-01

    Electron Spin Resonance (ESR) and 3-dimensional Thermoluminescence (3-D TL) spectra of natural diamond, high temperature-high pressure artificial diamond and high temperature-low pressure chemical vapor deposited (CVD) diamond were determined. The characteristics of spectra have been studied. It is found that isolated nitrogen, nitrogen exchange pair and nitrogen atom pair (S=1) are main forms of electron spin resonance nitrogen in natural and high temperature-high pressure artificial diamonds. The spectrum of CVD diamond is sampler, and contains only one peak caused by suspended bond of unsaturated carbon ones. For 3-D TL spectra, natural diamond has two peaks (∼370 nm and ∼510 nm) in 100-200 degree C temperature range, high temperature-high pressure artificial diamond only has ∼370 nm peak, and CVD diamond only has ∼500 nm peak. These characteristics would be useful for the quality inspection and classification of diamonds, as well as for the study of geologic actions associated with natural diamond

  2. Synthesis, characterization and ESR study of polyesters containing isomeric naphthylene units by gamma irradiation

    International Nuclear Information System (INIS)

    Choi, B.K.; Hill, D.J.T.; Choi, E.J.; Ahn, H.K.

    1998-01-01

    Full text: Aromatic polyesters containing naphthalene groups have interesting properties because the geometry of the naphthalene group can provide many of the structural features for the polymer chain. In this study we synthesized six polyesters from 4,4 ' - (hexafluoroisopropyl-idene)bis(benzoic acid) and isomeric naphthylene-diols. An ESR study of the radicals formed on gamma radiolysis of the polyesters has been undertaken to investigate their relative radiation sensitivities. The structures of the polyesters were characterized by means of IR spectroscopy. Inherent viscosities were measured in the range of 0.11 - 0.46 dL/g. Thermal properties of polyesters were determined by DSC and TGA thermograms, respectively. All polyesters were irradiated in an AECL Gamma cell with a dose rate of approximately 6.7kGy h -1 to doses in the range of 0 - 15kGy at 77K and 300K, respectively. In order to identify other radicals present at 77K, annealing studies were utilized by taking advantage of the different reactivities of these radicals

  3. A study of the red clover extract trinovin by ESR HPLC/MS and UVS

    International Nuclear Information System (INIS)

    Troup, G.; Hutton, D.; Hunter, C.; Hewitt, D.; Mulinacci, N.; Romani, A.; Pinelli, P.; Mancini, P.

    1999-01-01

    Full text: Trinovin is an extract of red clover, recently released on the dietary supplement market. It is recommended for 'Men's Health', because it contains the phenolics (isoflavones) genistein, biochanin, daidzein and formononetin, said to act as 'phytoestrogens', and is therefore a possible help in prostate gland problems. An Electron Spin Resonance (ESR) study (∼9.1Ghz, room temperature) revealed at least 3 different free radical lines, one with hyperfine structure, consistent with the listed molecules. Accordingly, HPLC/DAD (High Performance Liquid Chromatography/Diode Array Detector) and HPLC/Mass Spectroscopy analyses were performed in order to evaluate the quali-quantitative contents of flavonoidic compounds. The HPLC profile shows two main isoflavones and another three compounds, one of them being a quercetin glycoside. The quercetin glycosides are flavonoidic derivatives abundant in plant materials and present in wine. We can therefore say: even if the phytoestrogen properties claimed for Trinovin turn out to be less than hoped for, the antioxidants contained are very powerful, and so possibly helpful in protection against many diseases, including cancers, atherosclerosis, diabetic retinal bleeding, and non-alcoholic dementia

  4. The fate of primary cations in radiolysis of alkanes as studied by ESR

    International Nuclear Information System (INIS)

    Iwasaki, M.; Toriyama, K.; Nunome, K.

    1983-01-01

    The structures and reactions of alkane cations (RH + ) have been studied by ESR to elucidate the fate of primary cations in radiolysis of alkanes. Radical cations of prototype alkanes such as C 2 H 6 , C 3 H 8 , iso-C 4 H 10 and neo-C 5 H 12 etc. as well as their partially deuterated analogues were stabilized in irradiated frozen matrices such as SF 6 , CFCl 2 CF 2 Cl and CFCl 3 having a higher ionization potential than that of these alkanes contained as dilute solutes. RH + in SF 6 and in CFCl 2 CF 2 Cl converts into alkyl radicals by deprotonation probably through bimolecular reactions, whereas RH + in CFCl 3 unimolecularily decomposes into olefinic cations by H 2 and/or CH 4 elimination reactions. It is further found that the electronic structures of propane and isobutane cations in halocarbon matrices are different from those in SF 6 and the difference is drastically reflected in the site preference of their deprotonation reactions. The results are discussed in relation to the mechanisms of pairwise formation of alkyl radicals in low temperature radiolysis of neat alkanes and its suppression by addition of electron scavengers. (author)

  5. Discrimination of radiation quality through second harmonic out-of-phase cw-ESR detection.

    Science.gov (United States)

    Marrale, Maurizio; Longo, Anna; Brai, Maria; Barbon, Antonio; Brustolon, Marina

    2014-02-01

    The ability to discriminate the quality of ionizing radiation is important because the biological effects produced in tissue strongly depends on both absorbed dose and linear energy transfer (LET) of ionizing particles. Here we present an experimental electron spin resonance (ESR) analysis aimed at discriminating the effective LETs of various radiation beams (e.g., 19.3 MeV protons, (60)Co photons and thermal neutrons). The measurement of the intensities of the continuous wave spectrometer signal channel first harmonic in-phase and the second harmonic out-of-phase components are used to distinguish the radiation quality. A computational analysis, was carried out to evaluate the dependence of the first harmonic in-phase and second harmonic out-of-phase components on microwave power, modulation amplitude and relaxation times, and highlights that these components could be used to point out differences in the relaxation times. On the basis of this numerical analysis the experimental results are discussed. The methodology described in this study has the potential to provide information on radiation quality.

  6. Electron spin resonance (ESR) dose measurement in bone of Hiroshima A-bomb victim

    Science.gov (United States)

    2018-01-01

    Explosion of the bombs in Hiroshima and Nagasaki corresponds to the only historical moment when atomic bombs were used against civilians. This event triggered countless investigations into the effects and dosimetry of ionizing radiation. However, none of the investigations has used the victims’ bones as dosimeter. Here, we assess samples of bones obtained from fatal victims of the explosion by Electron Spin Resonance (ESR). In 1973, one of the authors of the present study (SM) traveled to Japan and conducted a preliminary experiment on the victims’ bone samples. The idea was to use the paramagnetism induced in bone after irradiation to measure the radiation dose. Technological advances involved in the construction of spectrometers, better knowledge of the paramagnetic center, and improvement in signal processing techniques have allowed us to resume the investigation. We obtained a reconstructed dose of 9.46 ± 3.4 Gy from the jawbone, which was compatible with the dose distribution in different locations as measured in non-biological materials such as wall bricks and roof tiles. PMID:29408890

  7. Gamma ray interaction with vanadyl ions in barium metaphosphate glasses; spectroscopic and ESR studies

    Science.gov (United States)

    Abdelghany, A. M.; ElBatal, H. A.; EzzElDin, F. M.

    2017-11-01

    Optical, FTIR, ESR investigations of prepared undoped barium metaphosphate glass and other samples with the same basic composition containing varying V2O5 contents (0.5, 1, 2, 3%) were carried out before and after gamma irradiation. The undoped glass shows a strong UV optical absorption which is correlated with unavoidable contaminated trace iron impurities. The V2O5-doped samples reveal two additional strong broad visible bands centered at 450 and 680 nm. Such extra peculiar and strong two broad visible bands are related to both tetravalent and trivalent vanadium ions in measurable percent due to the reducing behavior of barium phosphate host glass. Gamma irradiation on the undoped glass results in the generation of collective induced UV and visible bands which are originating from positive hole and electron centers. Glasses containing V2O5 reveal upon gamma irradiation induced defects in the UV as the undoped sample together with distinct splitting within the first broad visible band while the second broad band remains unchanged. This behavior is related to limited photoionization upon the addition of V2O5 indicating specific shielding effect of the vanadium ions towards gamma irradiation. It was noticed that irradiation causes no distinct variations in the FTIR spectra due to the presence of 50% of heavy metal oxide (BaO) and some shielding effect of vanadium ions.

  8. E.S.R. investigations of γ-irradiated AgNa-Y zeolites

    International Nuclear Information System (INIS)

    Abou-Kais, A.; Vedrine, J.C.; Naccache, C.

    1978-01-01

    Five different types of paramagnetic species related to silver nuclei were detected for γ-ray irradiated type Y zeolite in which Na + ions were exchanged by Ag + ions to different extents. One first species was identified as silver atoms almost freely diffusing in water contained in the zeolite cages. The second one corresponded to silver atoms interacting with lattice oxygens yet easily displaced to aluminium sites by slight warming. The unpaired spin delocalization to lattice nuclei was then rather significant at 36.3 and 21.2% respectively. The third species was assigned to Ag 2+ ions of d 9 character whose e.s.r. parameters reversibly depended on dehydration extent, confirming the dynamic properties of ions within zeolite material. The fourth species was attributed to AgH + arising from the action of liberated H atoms on Ag + . Finally, V- and F-type centres were observed, but could not be clearly identified. However, their parameters and their presence, compared to the case of non exchanged Na-Y zeolite sample, show that the electronic properties of framework nuclei are greatly perturbed by silver ions. For hydrated samples OH. radicals were also detected. (author)

  9. Radiogenic 3He/4He Estimates and Their Effect on Calculating Plio-Pleistocene Cosmogenic 3He Ages of Alluvial-Fan Terraces in the Lower Colorado River Basin, USA

    Science.gov (United States)

    Fenton, C.; Pelletier, J.

    2005-12-01

    Several alluvial-fan terraces near Topock, AZ were created by successive entrenchment of Pliocene and Pleistocene alluvial-fan gravels shed from the adjacent Black Mountains along the lower Colorado River corridor below Hoover Dam. These fans interfinger with and overlie main-stem Colorado River sands and gravels and grade to terrace levels that correspond with pre-existing elevations of the Colorado River. Absolute dates for the ages of Quaternary deposits on the lower Colorado River are rare and cosmogenic 3He age estimates of these surfaces would help constrain the timing of aggradation and incision in the lower Colorado River corridor. We analyzed individual basalt boulders from several terrace surfaces for total 3He/4He concentrations to calculate cosmogenic 3He ages of each fan terrace; 3He/4He values, expressed as R/Ra where Ra is the 3He/4He of air, range from 0.29 to 590. Black Mountain volcanic rocks have reported K-Ar ages between 15 and 30 Ma and basalt samples from adjacent alluvial fans contain 0.42 to 47× 1012 at/g of 4He, which has likely accumulated due to nuclear processes. The amount of radiogenic 3He/4He can be significant in old rocks with young exposure ages and can complicate determination of cosmogenic 3 He content. Alpha-decay of U, Th, and their daughter isotopes produces large amounts of 4He, whereas significant amounts of radiogenic 3He are only produced through the neutron bombardment of Li and subsequent beta-decay of tritium. We measured Li, U, Th, major and rare-earth element concentrations in whole-rock basalts and mineral separates. These concentrations are used to estimate the ratio of radiogenic helium contributed to the total helium system in our samples. Li concentrations typically range from 6 to 17 ppm, with one outlier of 62 ppm. U contents range from calculations predict that the average radiogenic helium (R/Ra) contributed to the total helium in Black Mountain basalt samples is 0.011. Other noble gas studies have shown

  10. Estradiol-induced regulation of GLUT4 in 3T3-L1 cells: involvement of ESR1 and AKT activation.

    Science.gov (United States)

    Campello, Raquel S; Fátima, Luciana A; Barreto-Andrade, João Nilton; Lucas, Thais F; Mori, Rosana C; Porto, Catarina S; Machado, Ubiratan F

    2017-10-01

    Impaired insulin-stimulated glucose uptake involves reduced expression of the GLUT4 (solute carrier family 2 facilitated glucose transporter member 4, SLC2A4 gene). 17β-estradiol (E 2 ) modulates SLC2A4 /GLUT4 expression, but the involved mechanisms are unclear. Although E 2 exerts biological effects by binding to estrogen receptors 1/2 (ESR1/2), which are nuclear transcriptional factors; extranuclear effects have also been proposed. We hypothesize that E 2 regulates GLUT4 through an extranuclear ESR1 mechanism. Thus, we investigated the effects of E 2 upon (1) subcellular distribution of ESRs and the proto-oncogene tyrosine-protein kinases (SRC) involvement; (2) serine/threonine-protein kinase (AKT) activation; (3) Slc2a4 /GLUT4 expression and (4) GLUT4 subcellular distribution and glucose uptake in 3T3-L1 adipocytes. Differentiated 3T3-L1 adipocytes were cultivated or not with E 2 for 24 h, and additionally treated or not with ESR1-selective agonist (PPT), ESR1-selective antagonist (MPP) or selective SRC inhibitor (PP2). Subcellular distribution of ESR1, ESR2 and GLUT4 was analyzed by immunocytochemistry; Slc2a4 mRNA and GLUT4 were quantified by qPCR and Western blotting, respectively; plasma membrane GLUT4 translocation and glucose uptake were analyzed under insulin stimulus for 20 min or not. E 2 induced (1) translocation of ESR1, but not of ESR2, from nucleus to plasma membrane and AKT phosphorylation, effects mimicked by PPT and blocked by MPP and PP2; (2) increased Slc2a4 /GLUT4 expression and (3) increased insulin-stimulated GLUT4 translocation and glucose uptake. In conclusion, E 2 treatment promoted a SRC-mediated nucleus-plasma membrane shuttle of ESR1, and increased AKT phosphorylation, Slc2a4 /GLUT4 expression and plasma membrane GLUT4 translocation; consequently, improving insulin-stimulated glucose uptake. These results unravel mechanisms through which estrogen improves insulin sensitivity. © 2017 Society for Endocrinology.

  11. Radiation damage of DNA constituents: ESR study of the adenosine:5-iodouracil cocrystal

    International Nuclear Information System (INIS)

    Zamorano, R.

    1986-01-01

    Single cocrystals of adenosine:5-iodouracil and partially deuterated adenosine:5-iodouracil were irradiated at 4.2K, 77K, and 300K with x-rays from a 3Mev Van de Graaff electron accelerator. Several types of free radicals were produced by the radiation and were studied by X-Band and Q-Band ESR from 77K to 300K. Six radicals were identified. Two electron addition products (radicals I1 and As1) and one electron abstraction product (radical 12) are stabilized at 77K. At room temperature two hydrogen addition radicals (I3 and As2) and a singlet radical (As3) are stabilized. Upon annealing to 165K after low temperature irradiation, radicals I1 and I2 decay to nonparamagnetic species. Radical As1 remains stable from 77K to 240K. From 240K to 300K the As1 radical decays and radicals As2 and I3 gradually grow in. Irradiation and observation at room temperature produces predominantly a singlet radical (As3). The electron addition radical, I1, is a σ*-type radical that presents the unpaired electron spin density localized mainly on the iodine atom. This radical does not de-halogenate, to produce the reactive uracilyl radical, but instead it decays into a non paramagnetic species when annealed from 77K to 300K. The low temperature radical population obtained in this cocrystal and the subsequent radical reactions upon annealing, contradict the hypothesis that, in the presence of purine:pyrimidine stacking interactions, electrons are transferred to the pyrimidines while holes are transferred to the purines

  12. ESR study of the anion radicals of 5-nitropyrimidines: conversion to iminoxy radicals

    International Nuclear Information System (INIS)

    Sevilla, M.D.; Clark, C.; Failor, R.

    1976-01-01

    The anion radicals of a number of 5-nitropyrimidines have been investigated by ESR spectroscopy. The anions are formed by electrolysis in dimethylformamide and by electron attachment in aqueous glasses, 12 M LiCl--D 2 O and 8 M NaOD. The electrolysis of 5-nitrouracil and 5-nitro-6-methyluracil results in relatively stable anion radicals. The results for 5-nitrouracil give evidence for two or perhaps three anions which differ only by the degree of ring nitrogen protonation. The results for 5-nitro-6-methyluracil suggest that the nitro group of the anion is twisted so that it is coupled only weakly to the ring π-electron system. The anions of 5-nitrouracil, 5-nitroorotic acid, 5-nitrobarbituric acid, and 5-nitro-6-methyluracil have been produced in the alkaline and neutral aqueous glasses. The anisotropic spectra found have been analyzed with the aid of computer simulations which assume axial symmetry. For example, the analysis of the spectrum of 5-nitrouracil anion in 12 M LiCl yields A/sub parallel//sup N/ = 33; A/sub perpendicular to//sup N/ = 5, a 6 /sup H/ = 5.5 G, g/sub parallel/ = 2.0016, and g/sub perpendicular to/ = 2.0059. A concentration dependence in the splittings is noted and discussed. Ultraviolet photolysis of the anions of 5-nitro-6-methyluracil and 5-nitrobarbituric acid results in the formation of iminoxy radicals. Mechanisms of formation of the iminoxy radicals are discussed and results found in this work are compared to results found in single crystals and aqueous solution

  13. Comparison of Disease Activity Score in 28 joints with ESR (DAS28), Clinical Disease Activity Index (CDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) & Routine Assessment of Patient Index Data with 3 measures (RAPID3) for assessing disease activity in patients with rheumatoid arthritis at initial presentation.

    Science.gov (United States)

    Kumar, B Siddhartha; Suneetha, P; Mohan, Alladi; Kumar, D Prabath; Sarma, K V S

    2017-11-01

    In patients with rheumatoid arthritis (RA), disease severity assessment is done using Disease Activity Score in 28 joints with ESR (DAS28). Computing DAS28 is time-consuming, requires laboratory testing and an online calculator. There is a need to validate rapid methods of disease severity assessment for routine daily use. This study was conducted to compare DAS28, Clinical Disease Activity Index (CDAI), Health Assessment Questionnaire Disability Index (HAQ-DI) and Routine Assessment of Patient Index Data with 3 measures (RAPID3) to assess the disease activity in patients with RA. We prospectively studied the utility of CDAI, HAQ-DI and RAPID3 scoring in 100 consecutive newly diagnosed, disease modifying antirheumatic drugs (DMARDs) naïve adult patients with RA seen during January 2013 and June 2014 at a tertiary care teaching hospital in south India. The mean age of the patients was 42.1±11.6 yr, there were 82 females. The median [interquartile range (IQR)] symptom duration was 6 (range 4-12) months. The median (IQR) DAS28, CDAI, HAQ-DI and RAPID3 scores at presentation were 7 (6-7), 36 (28-43), 2 (1-2) and 17 (13-19), respectively. A significant positive correlation was observed between DAS28 and CDAI (r=0.568; Pfair' agreement was observed in between DAS28 and CDAI (kappa-statistic=0.296). The agreement between DAS28 and HAQ-DI (kappa-statistic=0.007) and RAPID3 (kappa-statistic=0.072) was less robust. In adult patients with RA, in the setting where illiteracy is high, CDAI emerged as the preferred choice for rapid assessment of severity of disease at the time of initial presentation.

  14. ESR studies of radiation induced radical products from linoleic acid and linolenic acid and the radioprotective effect by α-tocopherol

    International Nuclear Information System (INIS)

    Zhu Younan; Tu Tiecheng; Dong Jirong; Zhang Jiashan; Li Nianyun

    1993-01-01

    Primary radicals from the γ-radiolysis of air-saturated linoleic acid and linolenic acid at 77 K, and the subsequent secondary radicals appeared during the course of variable temperature elevation were investigated by ESR. The ESR spectrum from samples irradiated and observed at 77 K shows the presence of the radical anion doublet arise from the electron adducts of the carboxy groups and the poorly resolved broad singlet results from some carbon-centered radicals. Annealing to approximately 125 K which allows for molecular oxygen migration results in the formation of peroxyl radicals. At 247 K, the ESR spectrum is a multi-line pattern which is attributable to structure of the α-carbon radical superimposed on the pentadienyl radicals. The ESR spectra from linoleic acid-α-tocopherol and linolenic acid-α-tocopherol binary systems irradiated at 77 K and recorded at 140 K or 215 K revealed the characteristic similarity to that from α-tocopherol alone, no trace of ESR signal from either peroxyl or the composite pattern from superposition of pentadienyl radical and α-carbon radicals can be found out. Therefore α-tocopherol has exerted radioprotection effect on peroxidation of linoleic acid and linolenic acid

  15. Polymorphisms in the LPL and CETP Genes and Haplotype in the ESR1 Gene Are Associated with Metabolic Syndrome in Women from Southwestern Mexico

    Directory of Open Access Journals (Sweden)

    José Ángel Cahua-Pablo

    2015-09-01

    Full Text Available Metabolic syndrome (MetS is a combination of metabolic disorders associated with an increased risk for cardiovascular disease (CVD. Studies in women reported associations between polymorphisms in ESR1, LPL and CETP genes and MetS. Our aim was to evaluate the association between variants in ESR1, LPL and CETP genes with MetS and its components. Four hundred and eighty women were analyzed, anthropometric features and biochemical profiles were evaluated, and genotyping was performed by real-time PCR. We found an association with elevated glucose levels (odds ratio (OR = 2.9; p = 0.013 in carrying the AA genotype of rs1884051 in the ESR1 gene compared with the GG genotype, and the CC genotype of rs328 in the LPL gene was associated with MetS compared to the CG or GG genotype (OR = 2.8; p = 0.04. Moreover, the GA genotype of rs708272 in the CETP gene is associated with MetS compared to the GG or AA genotype (OR = 1.8; p = 0.006. In addition the ACTCCG haplotype in the ESR1 gene is associated with a decrease in the risk of MetS (OR = 0.02; p < 0.001. In conclusion, our results show the involvement of the variants of ESR1, LPL and CETP genes in metabolic events related to MetS or some of its features.

  16. White paper of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) on multimodality imaging

    International Nuclear Information System (INIS)

    Bischof Delaloye, Angelika; Carrio, Ignasi; Cuocolo, Alberto; Knapp, Wolfram; Gourtsoyiannis, Nicholas; McCall, Iain; Reiser, Maximilian; Silberman, Bruno

    2007-01-01

    New multimodality imaging systems bring together anatomical and molecular information and require the competency and accreditation of individuals from both nuclear medicine and radiology. This paper sets out the positions and aspirations of the European Association of Nuclear Medicine (EANM) and the European Society of Radiology (ESR) working together on an equal and constructive basis for the future benefit of both specialties. EANM and ESR recognise the importance of coordinating working practices for multimodality imaging systems and that undertaking the nuclear medicine and radiology components of imaging with hybrid systems requires different skills. It is important to provide adequate and appropriate training in the two disciplines in order to offer a proper service to the patient using hybrid systems. Training models are proposed with the overall objective of providing opportunities for acquisition of special competency certification in multimodality imaging. Both organisations plan to develop common procedural guidelines and recognise the importance of coordinating the purchasing and management of hybrid systems to maximise the benefits to both specialties and to ensure appropriate reimbursement of these examinations. European multimodality imaging research is operating in a highly competitive environment. The coming years will decide whether European research in this area manages to defend its leading position or whether it falls behind research in other leading economies. Since research teams in the Member States are not always sufficiently interconnected, more European input is necessary to create interdisciplinary bridges between research institutions in Europe and to stimulate excellence. EANM and ESR will work with the European Institute for Biomedical Imaging Research (EIBIR) to develop further research opportunities across Europe. European Union grant-funding bodies should allocate funds to joint research initiatives that encompass clinical research

  17. White paper of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) on multimodality imaging

    International Nuclear Information System (INIS)

    Gourtsoyiannis, Nicholas; McCall, Iain; Reiser, Maximilian; Silberman, Bruno; Bischof Delaloye, Angelika; Carrio, Ignacio; Cuocolo, Alberto; Knapp, Wolfram

    2007-01-01

    New multimodality imaging systems bring together anatomical and molecular information and require the competency and accreditation of individuals from both radiology and nuclear medicine. This paper sets out the positions and aspirations of the European Society of Radiology (ESR) and the European Association of Nuclear Medicine (EANM) working together on an equal and constructive basis for the future benefit of both specialties. ESR and EANM recognise the importance of coordinating working practices for multimodality imaging systems and that undertaking the radiology and nuclear medicine components of imaging with hybrid systems requires different skills. It is important to provide adequate and appropriate training in the two disciplines in order to offer a proper service to the patient using hybrid systems. Training models are proposed with the overall objective of providing opportunities for acquisition of special competency certification in multimodality imaging. Both organisations plan to develop common procedural guidelines and recognise the importance of coordinating the purchasing and management of hybrid systems to maximise the benefits to both specialties and to ensure appropriate reimbursement of these examinations. European multimodality imaging research is operating in a highly competitive environment. The coming years will decide whether European research in this area manages to defend its leading position or whether it falls behind research in other leading economies. Since research teams in the member states are not always sufficiently interconnected, more European input is necessary to create interdisciplinary bridges between research institutions in Europe and to stimulate excellence. ESR and EANM will work with the European Institute for Biomedical Imaging Research (EIBIR) to develop further research opportunities across Europe. European Union grant-funding bodies should allocate funds to joint research initiatives that encompass clinical research

  18. Free radicals in pyrimidines: ESR of. gamma. -irradiated 5-cyclohexenyl-1,5-dimethyl barbituric acid. [/sup 60/Co

    Energy Technology Data Exchange (ETDEWEB)

    Benson, B. (Lehigh Univ., Bethlehem, PA); Erich, L.

    1981-06-01

    ESR studies have determined that ionizing radiation damage of hexobarbital (5-cyclohexenyl-1,5-dimethylbarbituric acid) causes the formation of a free radical (A) by hydrogen abstraction from the cyclohexenyl group. Hyperfine coupling tensors were determined for coupling of the unpaired electron to four protons. Visible light of wavelengths near 450 nm reversibly converts this radical to a second free radical (B) which also has the unpaired electron localized in the cyclohexenyl group. The activation energy for a thermally induced reverse conversion (B ..-->.. A) was determined to be 1.4 eV.

  19. Aberrant DNA methylation of ESR1 and p14ARF genes could be useful as prognostic indicators in osteosarcoma

    Directory of Open Access Journals (Sweden)

    Sonaglio V

    2013-06-01

    Full Text Available Viviane Sonaglio,1 Ana C de Carvalho,2 Silvia R C Toledo,3,4 Carolina Salinas-Souza,3,4 André L Carvalho,5 Antonio S Petrilli,3 Beatriz de Camargo,6 André L Vettore21Pediatrics Department, A C Camargo Hospital, São Paulo, Brazil; 2Biological Science Department, Federal University of São Paulo, Diadema, Brazil; 3Department of Pediatrics, Pediatric Oncology Institute, GRAACC/Federal University of São Paulo, São Paulo, Brazil; 4Department of Morphology and Genetics, Federal University of São Paulo, São Paulo, Brazil; 5Department of Head and Neck Surgery, PIO XII Foundation, Barretos Cancer Hospital, Barretos, São Paulo, Brazil; 6Research Program Pediatric Oncology Program, CPNq, Instituto Nacional do Cancer, Rio de Janeiro, BrazilAbstract: Osteosarcoma (OS is the eighth most common form of childhood and adolescence cancer. Approximately 10%–20% of patients present metastatic disease at diagnosis and the 5-year overall survival remains around 70% for nonmetastatic patients and around 30% for metastatic patients. Metastatic disease at diagnosis and the necrosis grade induced by preoperative treatment are the only well-established prognostic factors for osteosarcoma. The DNA aberrant methylation is a frequent epigenetic alteration in humans and has been described as a molecular marker in different tumor types. This study evaluated the DNA aberrant methylation status of 18 genes in 34 OS samples without previous chemotherapy treatment and in four normal bone specimens and compared the methylation profile with clinicopathological characteristics of the patients. We were able to define a three-gene panel (AIM1, p14ARF, and ESR1 in which methylation was correlated with OS cases. The hypermethylation of p14ARF showed a significant association with the absence of metastases at diagnoses, while ESR1 hypermethylation was marginally associated with worse overall survival. This study demonstrated that aberrant promoter methylation is a common event

  20. Effects of sphingosine and sphingosine analogues on the free radical production by stimulated neutrophils: ESR and chemiluminescence studies

    Directory of Open Access Journals (Sweden)

    A. Mouithys-Mickalad

    1997-01-01

    Full Text Available Sphingolipids inhibit the activation of the neutrophil (PMN NADPH oxidase by protein kinase C pathway. By electron spin resonance spectroscopy (ESR and chemiluminescence (CL, we studied the effects of sphingosine (SPN and ceramide analogues on phorbol 12-myristate 13-acetate (PMA, 5 × 10-7M stimulated PMN (6 × 106 cells. By ESR with spin trapping (100 mM DMPO: 5,5-dimethyl-1-pyrroline-Noxide, we showed that SPN (5 to 8 × 10-6M, C2-ceramide (N-acetyl SPN and C6-ceramide (N-hexanoyl SPN at the final concentration of 2 × 10-5 and 2 × 10-4M inhibit the production of free radicals by stimulated PMN. The ESR spectrum of stimulated PMN was that of DMPO-superoxide anion spin adduct. Inhibition by 5 × 10-6M SPN was equivalent to that of 30 U/ml SOD. SPN (5 to 8 × 10-6M has no effect on in vitro systems generating superoxide anion (xanthine 50 mM/xanthine oxidase 110 mU/ml or hydroxyl radical (Fenton reaction: 88 mM H2O2, 0.01 mM Fe2+ and 0.01 mM EDTA. SPN and N-acetyl SPN also inhibited the CL of PMA stimulated PMN in a dose dependent manner (from 2 × 10-6 to 10-5M, but N-hexanoyl SPN was less active (from 2 × 10-5 to 2 × 10-4M. These effects were compared with those of known PMN inhibitors, superoxide dismutase, catalase and azide. SPN was a better inhibitor compared with these agents. The complete inhibition by SPN of ESR signal and CL of stimulated PMN confirms that this compound or one of its metabolites act at the level of NADPH-oxidase, the key enzyme responsible for production of oxygen-derived free radicals.

  1. Oxidation of spin-traps by chlorine dioxide (ClO2) radical in aqueous solutions: first ESR evidence of formation of new nitroxide radicals.

    Science.gov (United States)

    Ozawa, T; Miura, Y; Ueda, J

    1996-01-01

    The reactivities of the chlorine dioxide (ClO2), which is a stable free radical towards some water-soluble spin-traps were investigated in aqueous solutions by an electron spin resonance (ESR) spectroscopy. The ClO2 radical was generated from the redox reaction of Ti3+ with potassium chlorate (KClO3) in aqueous solutions. When one of the spin-traps, 5,5-dimethyl-1-pyrroline N-oxide (DMPO), was included in the Ti3+-KClO3 reaction system, ESR spectrum due to the ClO2 radical completely disappeared and a new ESR spectrum [aN(1) = 0.72 mT, aH(2) = 0.41 mT], which is different from that of DMPO-ClO2 adduct, was observed. The ESR parameters of this new ESR signal was identical to those of 5,5-dimethylpyrrolidone-(2)-oxyl-(1) (DMPOX), suggesting the radical species giving the new ESR spectrum is assignable to DMPOX. The similar ESR spectrum consisting of a triplet [aN(1) = 0.69 mT] was observed when the derivative of DMPO, 3,3,5,5-tetramethyl-1-pyrroline N-oxide (M4PO) was included in the Ti3+-KClO3 reaction system. This radical species is attributed to the oxidation product of M4PO, 3,3,5,5-tetramethylpyrrolidone-(2)-oxyl-(1) (M4POX). When another nitrone spin-trap, alpha-(4-pyridyl-1-oxide)-N-t-butylnitrone (POBN) was used as a spin-trap, the ESR signal intensity due to the ClO2 radical decreased and a new ESR signal consisting of a triplet [aN(1) = 0.76 mT] was observed. The similar ESR spectrum was observed when N-t-butyl-alpha- nitrone (PBN) was used as a spin-trap. This ESR parameter [a(N)(1) = 0.85 mT] was identical to the oxidation product of PBN, PBNX. Thus, the new ESR signal observed from POBN may be assigned to the oxidation product of POBN, POBNX. These results suggest that the ClO2, radical does not form the stable spin adducts with nitrone spin-traps, but oxidizes these spin-traps to give the corresponding nitroxyl radicals. On the other hand, nitroso spin-traps, 5,5-dibromo-4-nitrosobenzenesulfonate (DBNBS), and 2-methyl-2-nitrosopropane (MNP) did not trap

  2. A comparison of three materials used in ESR dosimetry: L-α-alanine, DL-α-alanine and standard bone powder. Response to Co-60 gamma radiation

    International Nuclear Information System (INIS)

    Stuglik, Z.; Sadlo, J.

    1995-01-01

    Three solid state materials: L-α-alanine, DL-α-alanine and standard bone powder were irradiated with gamma analyzed with ESR method. It was stated that the G-value of paramagnetic centres in L-α-alanine is practically the same as in DL-alpha-alanine and about 50 times higher than in non-deproteinized bone powder. The sensitivities of investigated materials are proportional to their G-values if double integrals of ESR signals are chosen as a measure of radiation effects. When first derivatives of ESR absorption bands are used to the construction of dose-response curves (peak-to-peak method) the sensitivities of all investigated materials are comparable. (author). 14 refs, 1 fig., 3 tabs

  3. Dose calculation in biological samples in a mixed neutron-gamma field at the TRIGA reactor of the University of Mainz

    DEFF Research Database (Denmark)

    Schmitz, T.; Blaickner, M.; Schütz, C.

    2010-01-01

    and pin-diodes. Material and methods. When L-α-alanine is irradiated with ionizing radiation, it forms a stable radical which can be detected by electron spin resonance (ESR) spectroscopy. The value of the ESR signal correlates to the amount of absorbed dose. The dose for each pellet is calculated using......To establish Boron Neutron Capture Therapy (BNCT) for non-resectable liver metastases and for in vitro experiments at the TRIGA Mark II reactor at the University of Mainz, Germany, it is necessary to have a reliable dose monitoring system. The in vitro experiments are used to determine the relative......-calculations for mixed radiation fields and the Hansen & Olsen alanine detector response model. With the acquired data about the background dose and charged particle spectrum, and with the acquired information of the neutron flux, we are capable of calculating the dose to the tissue. Conclusion. Monte Carlo simulation...

  4. Impact of genetic variants of IL-6, IL6R, LRP5, ESR1 and SP7 genes on bone mineral density in postmenopausal Mexican-Mestizo women with obesity.

    Science.gov (United States)

    Méndez, Juan Pablo; Rojano-Mejía, David; Coral-Vázquez, Ramón Mauricio; Coronel, Agustín; Pedraza, Javier; Casas, María José; Soriano, Ruth; García-García, Eduardo; Vilchis, Felipe; Canto, Patricia

    2013-10-10

    Since obesity and osteoporosis present a high genetic predisposition and polymorphisms of IL-6, IL6R, LRP5, ESR1 and SP7 may influence the risk of both diseases, the aim of this study was to analyze the possible association of polymorphisms in these genes, as well as their haplotypes, with BMD variations in postmenopausal Mexican-Mestizo women with grade 2 or grade 3 obesity. One hundred eighty unrelated postmenopausal women with grade 2 or grade 3 obesity were included. BMD was measured in total hip and lumbar spine by dual-energy X-ray absorptiometry. DNA was obtained from blood leukocytes. Rs1800795 of IL-6, rs2228145 of IL6R, rs3736228 of LRP5, rs9340799 (XbaI) and rs2234693 (PvuII), of ESR1, rs10876432 and rs2016266, of SP7 (and their haplotypes), were studied by real-time PCR allelic discrimination. Deviations from Hardy-Weinberg equilibrium were tested. Pairwise linkage disequilibrium between single nucleotide polymorphisms was calculated by direct correlation r(2), and haplotype analysis was conducted. Using WHO criteria, 54.5% had grade 2 obesity, and 45.5% had grade 3 obesity. Regarding DXA results, 11.1% women had osteoporosis, 41.7% had osteopenia, and 47.2% had normal BMD. Genotype and haplotype analysis showed no significant differences with BMD variations at the lumbar spine, total hip or femoral neck. We did not find a significant association between the polymorphisms analyzed or their haplotypes and BMD variations in postmenopausal women with obesity. The higher BMD observed in women with obesity could be the result of an adaptive response to the higher loading of the skeleton. © 2013 Elsevier B.V. All rights reserved.

  5. Electron Spin Resonance (ESR) and Thermoluminescence (TL) studies of stalagmitic floors of the Caune de de L'Arago at Tautavel (France)

    International Nuclear Information System (INIS)

    Poupeau, G.; Teles, M.M.; Rossi, A.; Zuleta, E.; Yokoyama, Y.

    1984-01-01

    The geological radiation dose to the stalagmites of various stratigraphic levels of the Caune de L'Arago at Tautavel has been measured by Thermoluminescence (TL) and Electron Spin Resonance (ESR). In all samples the TL natural spectrum a well developped 280 0 C peak and a subordinate 350 0 C peak, while the ESR line spectrum may present the h 1 , h 2 and h 3 radiative lines of Yokoyama et al.) or only h 2 . All TL peaks and ESR lines do increase with the laboratory applied radiation (β or γ) doses. The activated h 2 line is visibly unstable in laboratory conditions as well as apparently the h 3 line in one sample. Within the experimental precision, the geological doses determined from the 280C peak and h 3 line on one band and the 350 0 C peak and h 1 line (after thermal treatment of the later, see Yokoyama et al. on the other hand are identical. When the 280C natural peak is visibly affected by natural fading as shown by the plateau test, so is h 3 , and the geological doses of the 280 0 C-h 3 peaks are lowered by the same factor as compared to those of the 350 0 C-h 1 peaks. Annealing experiments show that the relationships between the TL and ESR peaks may be difficult to analyse in some samples due to the possible occurence of non radiative components in some ESR lines. Such components appear clearly at temperatures above approx. 180-200 0 C and might possibly be present below. This may have important implications for the selection of samples to be dated by ESR. (Author) [pt

  6. ESR studies on the influence of physiological dissolution and digestion media on the lipid phase characteristics of SEDDS and SEDDS pellets.

    Science.gov (United States)

    Abdalla, Ahmed; Mäder, Karsten

    2009-02-09

    The aim of the current study is the evaluation of a recently optimized SEDDS, composed of Solutol HS15 and medium chain glycerides, and self-emulsifying pellets by means of ESR. Tempol-benzoate (TB)-loaded SEDDS were produced and electron spin resonance (ESR) spectroscopy was used to evaluate the diluted self-emulsifying mixtures. Moreover, ESR in vitro digestion experiments were carried out to have an insight on the characteristics of the different phases formed during the digestion process and to evaluate the distribution and the localization of TB in these phases. In addition, self-emulsifying pellets were produced using nitroxide-loaded SEDDS and the microenvironment within the pellets during release process was monitored in an online process using ESR spectroscopy. After dilution of nitroxide-loaded SEDDS, the percent of TB localized in the lipophilic compartment was decreasing with increasing the surfactant fraction in the mixture. Moreover, it was found that different phases with variable viscosity and polarity were produced as a result of the enzymatic digestion of SEDDS in physiologically relevant media. This change in lipid composition has largely affected the distribution and the localization of the spin probe during the digestion process. A rapid increase in the mobility of the spin probe inside the pellets was noticed after exposure to the release media. Additionally, TB was localized within the self-emulsifying mixture environment for the time of the experiment. ESR is considered a powerful non-invasive tool to assess the microenvironment of the diluted SEDDS and to monitor in vitro digestion process. Digestion induces a change in lipid composition which can affect the solubilization capacity of the administered drug. Therefore, monitoring in vitro digestion process using ESR spectroscopy will help in providing greater understanding of the interaction between the administered drug and the digested lipid vehicles.

  7. ESR1 gene promoter region methylation in free circulating DNA and its correlation with estrogen receptor protein expression in tumor tissue in breast cancer patients

    International Nuclear Information System (INIS)

    Martínez-Galán, Joaquina; Ríos, Sandra; Delgado, Juan Ramón; Torres-Torres, Blanca; Núñez, María Isabel; López-Peñalver, Jesús; Del Moral, Rosario; Ruiz De Almodóvar, José Mariano; Menjón, Salomón; Concha, Ángel; Chamorro, Clara

    2014-01-01

    Tumor expression of estrogen receptor (ER) is an important marker of prognosis, and is predictive of response to endocrine therapy in breast cancer. Several studies have observed that epigenetic events, such methylation of cytosines and deacetylation of histones, are involved in the complex mechanisms that regulate promoter transcription. However, the exact interplay of these factors in transcription activity is not well understood. In this study, we explored the relationship between ER expression status in tumor tissue samples and the methylation of the 5′ CpG promoter region of the estrogen receptor gene (ESR1) isolated from free circulating DNA (fcDNA) in plasma samples from breast cancer patients. Patients (n = 110) with non-metastatic breast cancer had analyses performed of ER expression (luminal phenotype in tumor tissue, by immunohistochemistry method), and the ESR1-DNA methylation status (fcDNA in plasma, by quantitative methylation specific PCR technique). Our results showed a significant association between presence of methylated ESR1 in patients with breast cancer and ER negative status in the tumor tissue (p = 0.0179). There was a trend towards a higher probability of ESR1-methylation in those phenotypes with poor prognosis i.e. 80% of triple negative patients, 60% of HER2 patients, compared to 28% and 5.9% of patients with better prognosis such as luminal A and luminal B, respectively. Silencing, by methylation, of the promoter region of the ESR1 affects the expression of the estrogen receptor protein in tumors of breast cancer patients; high methylation of ESR1-DNA is associated with estrogen receptor negative status which, in turn, may be implicated in the patient’s resistance to hormonal treatment in breast cancer. As such, epigenetic markers in plasma may be of interest as new targets for anticancer therapy, especially with respect to endocrine treatment

  8. Contested embryonic culture in Japan--public discussion, and human embryonic stem cell research in an aging welfare society.

    Science.gov (United States)

    Sleeboom-Faulkner, Margaret

    2010-01-01

    This article explores the reasons for the lack of a broad discussion on bioethical regulation of human embryonic stem cell research (hESR) in Japan and asks why scientists experience difficulties accessing resources for hESR despite the acclaimed indifference of dominant Japanese culture to embryo research. The article shows how various social actors express their views on the embryo and oocyte donation in terms of dominant Japanese culture, foiled against what is regarded as Western culture. Second, it shows how the lack of concern with hESR should be understood in the context of public health policies and communications and bioethics decision making in Japan. Finally, it interprets the meaning of the embryo in the context of Japan as an aging modern welfare society, explaining how policymakers have come to emphasize the urgency of infertility problems over issues around abortion and embryonic life.

  9. Characterization of WO3-doped borophosphate glasses by optical, IR and ESR spectroscopic techniques before and after subjecting to gamma irradiation

    International Nuclear Information System (INIS)

    Ouis, M.A.; EI-Batal, H.A.; Azooz, M.A.; Abdelghany, A.M.

    2013-01-01

    Borophosphate glasses containing increasing WO 3 within the doping level (0.16-1.33%) have been prepared and investigated by UV-visible, infrared spectral measurements. These glasses have been exposed to gamma rays with a dose of 8 Mrad for studying the effect of gamma radiation on the combined studied spectra of such glasses. The optical spectrum of undoped borophosphate glass reveals strong UV absorption but with no visible bands. This strong UV absorption is related to the presence of unavoidable trace iron impurities within the chemicals used for the preparation of this borophosphate glass. The WO 3 -doped samples show two additional UV and visible bands at about 380 and 740 nm due to the presence of both W 6+ and W 5+ ions in noticeable content. The calculated induced spectra reveal the appearance of an ultraviolet band at 320 nm and two visible bands centered at 390 and 540 nm which are related to the combined presence of W 6+ and W 5+ ions. The FTIR spectra show vibrational bands due to characteristic constitutional phosphate and borate groups but the phosphate groups are predominant due to the high P 2 O 5 content (50%). The effect of the addition of WO 3 with the dopant level reveals limited changes in the IR spectra. Electron spin resonance (ESR) spectra show specified signals in the high WO 3 content glass but on gamma irradiation the signals are disappeared. This result confirms the decrease of the W 5+ ions by photochemical oxidation to paired W 6+ ions. This result is also observed in optical absorption of WO 3 doped glasses after gamma irradiation through the disappearance of the visible band at 740 nm. (author)

  10. Coordinated research efforts for establishing an international radiotherapy dose intercomparison service based on the alanine/ESR system

    International Nuclear Information System (INIS)

    Nette, H.P.; Onori, S.; Fattibene, P.; Regulla, D.; Wieser, A.

    1993-01-01

    The IAEA has long been active in the field of high-dose standardization. An International Dose Assurance Service (IDAS) was established based on alanine/ESR dosimetry. This service operates over the range of 100 Gy to 100 kGy and is directed towards industrial radiation processing in IAEA member states. It complements the IAEA/WHO TLD postal dose intercomparison service for dose assurance in hospital radiotherapy departments. Experience with the alanine high dose service suggests that the alanine dosimeter might provide superior performance to TLD in the therapy dose range. Preliminary test measurements with the participation of GSF/Germany, Istituto Superiore di Sanita/Italy (both providing alanine dosimeters and their evaluation) and IAEA (providing reference irradiations) seems to justify research efforts through an IAEA Coordinated Research Programme (CRP). This CRP, entitled ''Therapy Level Dosimetry with the Alanine/ESR System'' is presently under set-up. It will include general work common to all assigned/potential contract holders as well as some specific research topics in accordance to individual proposals of each participant. (author)

  11. Distribution of free radical products among the bases of x-irradiated DNA model systems: an ESR study

    International Nuclear Information System (INIS)

    Spalletta, R.A.

    1984-01-01

    Exposure of solid state DNA to ionizing radiation results in an ESR spectrum that has been attributed to a nonstoichiometric distribution of free radicals among the bases. At low temperatures radical cations appear to be stabilized on the purines while radical anions are stabilized on the pyrimidines. This distribution could arise from at least two different mechanisms. The first, charge transfer, involves the transfer of electrons and/or holes between stacked bases. In the second, saturation asymmetry, the free radical distribution arises from differences in the dose saturation characteristics of individual bases. The present study addresses the relative importance of charge transfer versus saturation asymmetry in the production of these population differences. Radicals formed by dissolving irradiated polycrystalline pyrimidines in aqueous solutions containing NtB or PBN spin traps were analyzed using ESR. The relative importance of the two free radical production and distribution mechanisms was assessed using DNA model systems. Saturation asymmetry plays a significant role in determining the free radical population while charge transfer was unambiguously observed in only one, the complex of dAMP and TMP. The results demonstrate that any quantitative analysis of charge transfer must take saturation asymmetry into account

  12. Self-assembled organic radicals on Au(111) surfaces: a combined ToF-SIMS, STM, and ESR study.

    Science.gov (United States)

    Mannini, Matteo; Sorace, Lorenzo; Gorini, Lapo; Piras, Federica M; Caneschi, Andrea; Magnani, Agnese; Menichetti, Stefano; Gatteschi, Dante

    2007-02-27

    Electron spin resonance (ESR), time-of-flight secondary ion mass spectrometry (ToF-SIMS), and scanning tunneling microscopy (STM) have been used in parallel to characterize the deposition on gold surface of a series of nitronyl nitroxide radicals. These compounds have been specifically synthesized with methyl-thio linking groups suitable to interact with the gold surface to form self-assembled monolayers (SAMs), which can be considered relevant in the research for molecular-based spintronics devices, as suggested in recent papers. The degree of the expected ordering on the surface of these SAMs has been tuned by varying the chemical structure of synthesized radicals. ToF-SIMS has been used to support the evidence of the occurrence of the deposition process. STM has shown the different qualities of the obtained SAMs, with the degree of local order increasing as the degree of freedom of the molecules on the surface is decreased. Finally, ESR has confirmed that the deposition process does not affect the paramagnetic characteristics of radicals and that it affords a complete single-layered coverage of the surface. Further, the absence of angular dependence in the spectra indicates that the small regions of local ordering do not give rise to a long-range order and suggests a quite large mobility of the radical on the surface, probably due to the weak interaction with gold provided by the methyl-thio linking group.

  13. Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

    Directory of Open Access Journals (Sweden)

    Shunqiang Li

    2013-09-01

    Full Text Available To characterize patient-derived xenografts (PDXs for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation.

  14. Dynamic crossovers and activated regimes in a narrow distribution poly(n-butyl acrylate): an ESR study

    Energy Technology Data Exchange (ETDEWEB)

    Andreozzi, Laura; Autiero, Ciro; Faetti, Massimo; Giordano, Marco; Zulli, Fabio [Department of Physics ' E Fermi' , University of Pisa, largo Pontecorvo 3, 56127 Pisa (Italy); polyLAB-CNR, largo Pontecorvo 3, 56127 Pisa (Italy)

    2006-07-19

    The rotational dynamics of the spin probe cholestane dissolved in a narrow distribution poly(n-butyl acrylate) sample has been investigated via electron spin resonance (ESR) spectroscopy. The measurements were carried out in a wide temperature range: different dynamic regions have been recognized, and the coupling of the probe dynamics to the {alpha} and secondary relaxations has been revealed. In particular, the coupling with the structural relaxation is ruled by two fractionary Vogel-Fulcher laws (VF). The crossover from one VF region to the other occurs at the temperature T{sub C} = 1.17T{sub g}, signalling the onset of the cooperativity in the dynamics and confirming a behaviour previously observed in ESR studies carried out on polymeric glass-formers. Furthermore, in this work we discuss the activated regime at the highest temperatures and show that the activation energy does not depend on the length of the polymer main- and side-chains, while its onset temperature linearly depends on the chain length.

  15. Study of intrinsic energy dependence of α-alanine and dose intercomparison with ESR and ISE techniques

    International Nuclear Information System (INIS)

    Laere, K. van; Bartolotta, A.; Callens, F.

    1993-01-01

    The intrinsic energy behavior of the radiation chemical yields G(R ·) and G(NH 3 ) which determine the dose response for the alanine/ESR and alanine/Ion-Selective Electrode (ISE) system, is an important characteristic for the consistent use in different radiation environments. Therefore, the response of ISS and Gent α-alanine dosimeters in the dose range 0.1 to 700 kGy was examined with 60 Co, bremsstrahlung and electron beam radiation. Bremsstrahlung beams with end point energy between 5 and 12 MeV and electron beams with mean energy at the effective point of measurement between 4 and 25 MeV were used. Analysis of the 60 Co calibration results shows that there are no significant differences in dose determination between the two laboratories. The statistical evaluation of 41 sets of independent series of measurements has shown no significant variation with beam energy. The results also confirm good consistency between ISE and ESR measurements. (author)

  16. Dynamic crossovers and activated regimes in a narrow distribution poly(n-butyl acrylate): an ESR study

    International Nuclear Information System (INIS)

    Andreozzi, Laura; Autiero, Ciro; Faetti, Massimo; Giordano, Marco; Zulli, Fabio

    2006-01-01

    The rotational dynamics of the spin probe cholestane dissolved in a narrow distribution poly(n-butyl acrylate) sample has been investigated via electron spin resonance (ESR) spectroscopy. The measurements were carried out in a wide temperature range: different dynamic regions have been recognized, and the coupling of the probe dynamics to the α and secondary relaxations has been revealed. In particular, the coupling with the structural relaxation is ruled by two fractionary Vogel-Fulcher laws (VF). The crossover from one VF region to the other occurs at the temperature T C = 1.17T g , signalling the onset of the cooperativity in the dynamics and confirming a behaviour previously observed in ESR studies carried out on polymeric glass-formers. Furthermore, in this work we discuss the activated regime at the highest temperatures and show that the activation energy does not depend on the length of the polymer main- and side-chains, while its onset temperature linearly depends on the chain length

  17. Interlaboratory tests to identify irradiation treatment of various foods via gas chromatographic detection of hydrocarbons, ESR spectroscopy and TL analysis

    Energy Technology Data Exchange (ETDEWEB)

    Schreiber, G.A.; Helle, N.; Schulzki, G.; Linke, B.; Spiegelberg, A.; Mager, M.; Boegl, K.W. [BgVV - Federal Inst. for Health Protection of Consumers and Veterinary Medicine, Berlin (Germany)

    1996-12-31

    The gas chromatographic (GC) analysis of radiation-induced volatile hydrocarbons (HC) and 2-alkylcyclobutanones, the ESR spectroscopic detection of radiation-specific radicals and the thermoluminescence (TL) analysis of silicate mineral are the most important methods for identification of irradiated foods. After successful performance in interlaboratory studies on meat products, fish, spices, herbs and shells of nuts, all or some of these methods have been approved by national authorities in Germany and the United Kingdom. Recently, draft European Standards have been elaborated for approval by member states of the European Committee for Standardization (CEN). Several research laboratories have shown that these methods can be applied to various foods not yet tested in collaborative studies. However, for an effective application in food control it is necessary to prove their suitability in interlaboratory studies. Therefore, in 1993/94, various interlaboratory tests were organised by the BgVV. In an ESR spectroscopic test, shrimps and paprika powder were examined. Shrimps were also the subject of examination in a TL test. Finally, GC detection of radiation-induced hydrocarbons in the fat fraction of foods was used in another test to identify irradiated Camembert, avocado, papaya and mango. In the following paper, results of the interlaboratory tests are summarised. Detailed reports are published by this institute. (author).

  18. Interlaboratory tests to identify irradiation treatment of various foods via gas chromatographic detection of hydrocarbons, ESR spectroscopy and TL analysis

    International Nuclear Information System (INIS)

    Schreiber, G.A.; Helle, N.; Schulzki, G.; Linke, B.; Spiegelberg, A.; Mager, M.; Boegl, K.W.

    1996-01-01

    The gas chromatographic (GC) analysis of radiation-induced volatile hydrocarbons (HC) and 2-alkylcyclobutanones, the ESR spectroscopic detection of radiation-specific radicals and the thermoluminescence (TL) analysis of silicate mineral are the most important methods for identification of irradiated foods. After successful performance in interlaboratory studies on meat products, fish, spices, herbs and shells of nuts, all or some of these methods have been approved by national authorities in Germany and the United Kingdom. Recently, draft European Standards have been elaborated for approval by member states of the European Committee for Standardization (CEN). Several research laboratories have shown that these methods can be applied to various foods not yet tested in collaborative studies. However, for an effective application in food control it is necessary to prove their suitability in interlaboratory studies. Therefore, in 1993/94, various interlaboratory tests were organised by the BgVV. In an ESR spectroscopic test, shrimps and paprika powder were examined. Shrimps were also the subject of examination in a TL test. Finally, GC detection of radiation-induced hydrocarbons in the fat fraction of foods was used in another test to identify irradiated Camembert, avocado, papaya and mango. In the following paper, results of the interlaboratory tests are summarised. Detailed reports are published by this institute. (author)

  19. Structure of very heavy few-electron ions - new results from the heavy ion storage ring, ESR

    International Nuclear Information System (INIS)

    Mokler, P.H.; Stoehlker, T.; Kozhuharov, C.; Moshammer, R.; Rymuza, P.; Bosch, F.; Kandler, T.

    1993-08-01

    The heavy ion synchrotron/storage ring facility at GSI, SIS/ESR, provides intense beams of cooled, highly-charged ions up to naked uranium (U 92+ ). By electron capture during ion-atom collisions in the gas target of the ESR or by recombination at ion-electron encounters in the ''electron cooler'' excited states are populated. The detailed structure of very heavy one-, two- and three-electron ions is studied. The different mechanisms leading to the excited states are described, as well as the new experimental tools now available for a detailed spectroscopy of these interesting systems. Special emphasis is given to X-ray transitions to the groundstates in H- and He-like systems. For the heaviest species the groundstate Lambshift can now be probed on an accuracy level of better than 10% using solid-state X-ray detectors. Applying dispersive X-ray analyzing techniques, this accuracy will certainly be improved in future. However, utilizing the dielectronic resonances for a spectroscopy, the structure in Li-like heavy ions can already be probed now on the sub eV level. (orig.)

  20. Predictive values derived from lower wisdom teeth developmental stages on orthopantomograms to calculate the chronological age in adolescence and young adults as a prerequisite to obtain age-adjusted informed patient consent prior to elective surgical procedures in young patients with incomplete or mismatched personal data.

    Science.gov (United States)

    Friedrich, Reinhard E; Schmidt, Kirsten; Treszl, András; Kersten, Jan F

    2016-01-01

    Introduction: Surgical procedures require informed patient consent, which is mandatory prior to any procedure. These requirements apply in particular to elective surgical procedures. The communication with the patient about the procedure has to be comprehensive and based on mutual understanding. Furthermore, the informed consent has to take into account whether a patient is of legal age. As a result of large-scale migration, there are eventually patients planned for medical procedures, whose chronological age can't be assessed reliably by physical inspection alone. Age determination based on assessing wisdom tooth development stages can be used to help determining whether individuals involved in medical procedures are of legal age, i.e., responsible and accountable. At present, the assessment of wisdom tooth developmental stages barely allows a crude estimate of an individual's age. This study explores possibilities for more precise predictions of the age of individuals with emphasis on the legal age threshold of 18 years. Material and Methods: 1,900 dental orthopantomograms (female 938, male 962, age: 15-24 years), taken between the years 2000 and 2013 for diagnosis and treatment of diseases of the jaws, were evaluated. 1,895 orthopantomograms (female 935, male 960) of 1,804 patients (female 872, male 932) met the inclusion criteria. The archives of the Department of Diagnostic Radiology in Dentistry, University Medical Center Hamburg-Eppendorf, and of an oral and maxillofacial office in Rostock, Germany, were used to collect a sufficient number of radiographs. An effort was made to achieve almost equal distribution of age categories in this study group; 'age' was given on a particular day. The radiological criteria of lower third molar investigation were: presence and extension of periodontal space, alveolar bone loss, emergence of tooth, and stage of tooth mineralization (according to Demirjian). Univariate and multivariate general linear models were calculated