WorldWideScience

Sample records for erwachsenen nach krebs

  1. Infectious spondylitis in adults; Infektioese Spondylitis beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Vorbeck, F. [Abt. fuer Osteologie, Universitaetsklinik fuer Radiodiagnostik, Wien (Austria); Morscher, M. [Universitaetsklinik fuer Orthopaedie, Wien (Germany); Ba-Ssalamah, A. [Abt. fuer Osteologie, Universitaetsklinik fuer Radiodiagnostik, Wien (Austria); Imhof, H. [Abt. fuer Osteologie, Universitaetsklinik fuer Radiodiagnostik, Wien (Austria)

    1996-10-01

    In adults, infectious spondylitis is a rare but sever disease, caused by a bacterial thrombus in tissue of reduced resistance. In conventional radiographs initial findings are a narrowing of the intervertebral space, local osteoporosis and poorly defined erosive borders of the vertebral endplates. These changings can be found at least three to six weeks after the onset of disease. However, in Szintigraphy and MRT pathologic alterations are evident after ten to twelve days. Thus, early diagnosis and treatment becomes possible. In early stages of the disease of localized lysis surrounded by a reactive sclerosis appears in predisposed areas of the vertebral body (subchondral, anterobasal, ventral, central). Apparently, a soft tissue tumor is associated. Sclerosis and reduction of the soft tissue tumor are the first signs of repair processes. After at least 12 weeks, computed tomography can reveal typical sintering of the vertebral body and occasionally the development of a bony sequester. In addition, MRT as well as CT can be helpful in the detection and localization of complications as abscesses or affection of the vertebral canal. The tuberculous spondylitis can sometimes cause difficulties in differential diagnosis. Clinical findings, affection of several vertebral bodies, large soft tissue tumors with appearance of calcification as well as not typical locations are strongly suggestive of tuberculous spondylitis, but these findings are not specific of the disease. Degenerative disorders such as erosive osteochondrosis or changings due ot chronic dialysis (e.g amyloid or crystal arthropathies) may cause even more problems in differential diagnosis. Typical for a blastomatous process is the integrity of the interverebral disc space, which is a rare finding in spondylitis. (orig.) [Deutsch] Die Spondylitis des Erwachsenen ist eine zwar seltene, aber vor allem bei verzoegerter Diagnose eine ernste und langwierige Erkrankung, die auf einen Bakterienembolus im

  2. Krebs, Prof. Hans Adolf

    Indian Academy of Sciences (India)

    Krebs, Prof. Hans Adolf Nobel Laureate (Medicine) - 1953. Date of birth: 25 August 1900. Date of death: 22 November 1981. YouTube; Twitter ... Summer Schools. Posted on 21 December 2017. ASTROPHYSICS: An Observational View of the Universe. Math Art and Design: MAD about Math, Math Education and Outreach.

  3. Teaching the Krebs Cycle.

    Science.gov (United States)

    Akeroyd, F. Michael

    1983-01-01

    Outlines a simple but rigorous treatment of the Krebs Cycle suitable for A-level Biology students. The importance of the addition of water molecules in various stages of the cycle is stressed as well as the removal of hydrogen atoms by the oxidizing enzymes. (JN)

  4. Krebs Cycle Wordsearch

    Science.gov (United States)

    Helser, Terry L.

    2001-04-01

    This puzzle embeds 46 names, terms, abbreviations, and acronyms about the citric acid (Krebs) cycle in a 14- x 17-letter matrix. A descriptive narrative beside it describes important features of the pathway. All the terms a student needs to find are embedded there with the first letter followed by underlined blanks to be completed. Therefore, the students usually must find the terms to know how to spell them, correctly fill in the blanks in the narrative with the terms, and then find and highlight the terms in the letter matrix. When all are found, the 24 unused letters complete a sentence that describes a major feature of this central pathway. The puzzle may be used as homework, an extra-credit project, or a group project in the classroom in any course where basic metabolism is learned. It disguises as fun the hard work needed to learn the names of the intermediates, enzymes, and cofactors.

  5. Lebensqualität bei Langzeitüberlebenden nach akuter lymphatischer Leukämie des Erwachsenen

    OpenAIRE

    Hellenbrecht, Anja

    2009-01-01

    Ein zentrales Ergebnis dieser Studie war, dass viele Patienten ein hohes Maß an Lebens-qualität zeigten. Verglichen mit anderen hämatologisch-onkologischen Kollektiven lag die Lebensqualität der Patienten dieser Studie deutlich näher bei den Werten der gesunden Normalbevölkerung. Als signifikant negative Einflussfaktoren auf die verschiedenen Dimensionen der Lebensqualität zeigte sich die allogene Stammzelltransplantation und ein Alter > 55 Jahren. Stammzelltransplantierte und ältere Patiente...

  6. Transplantationsosteopathie: Knochenstoffwechsel nach Nierentransplantation

    Directory of Open Access Journals (Sweden)

    Kovarik J

    2001-01-01

    Full Text Available Die Osteopathie nach Nierentransplantation ist eine klinische Entität, als deren wesentlichste ätiologische Faktoren einerseits die Persistenz des sekundären Hyperparathyreoidismus, andererseits die Immunsuppression verantwortlich gemacht werden. Nierentransplantierte Patienten zeichnen sich außerdem dadurch aus, daß ihre Knochenerkrankung auf der Basis einer präexistenten renalen Osteopathie entsteht. Daten über die renale Posttransplantationsosteopathie sind in der Literatur dürftig und zum Teil kontrovers abgehandelt. Grund dafür sind inhomogene Patientengruppen, die Verwendung unterschiedlicher immunsuppressiver Protokolle, unterschiedliche Diagnosewege und Diagnosekriterien sowie das Fehlen prospektiver Untersuchungen.

  7. Osteopathien nach Lungentransplantation

    Directory of Open Access Journals (Sweden)

    Aringer M

    1999-01-01

    Full Text Available Mit der immer besser werdenden Lebenserwartung von Patienten nach Lungentransplantation gewinnen knöcherne Komplikationen an Bedeutung. Parallel zu anderen Gruppen haben wir die Häufigkeit von Frakturen, die Knochendichte und Knochenstoffwechselparameter von in Wien transplantierten Patienten untersucht. Aus dieser Querschnittsstudie geht eine extrem hohe Osteopathie-Prävalenz hervor, viele Patienten weisen einen Vitamin D-Mangel auf. Der Knochenstoffwechsel ist gesteigert, teilweise im Zusammenhang mit einem sekundären Hyperparathyreoidismus. Wir diskutieren hier unsere Resultate vor dem Hintergrund der anderen publizierten Untersuchungen.

  8. Differences in the sensitivity of children and adults to carciogenic substances - literature study; Unterschiede in der Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen im Vergleich zu Erwachsenen - Literaturstudien

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K. [Forschungs- und Beratungsinstitut Gefahrstoffe GmbH (FoBiG), Freiburg (Germany)

    1999-06-01

    Wirkungen durch radioaktive Strahlung ist belegt, dass exponierte Kinder im Vergleich zu Erwachsenen eine hoehere Empfindlichkeit fuer Brustkrebs, Leukaemie und Schilddruesentumoren aufweisen. In Bezug auf chemische Stoffe stammen relevante Hinweise aus tierexperimentellen Untersuchungen mit Vinylchlorid und anderen Substanzen (z.B. Nitrosamine und -amide, PAK, 2-Acetylaminofluoren, Benzidin, Aflatoxin B{sub 1}, Cycasin, Urethan), die hoehere Tumorinzidenzen bei Exposition junger Tiere ergaben als bei erwachsenen Tieren unter vergleichbaren Expositionsbedingungen. Alle genannten Substanzen sind gentoxische Kanzerogene und mechanistische Studien lassen es plausibel erscheinen, dass hohe Zellteilungsraten in den Organen des wachsenden Organismus in Verbindung mit der gentoxischen Aktivitaet der Stoffe zu hohen Tumorinzidenzen fuehren. Fuer das nicht gentoxisch wirkende Blasenkanzerogen Saccharin zeigt eine Studie, dass zusaetzliche Exposition vor und nach der Geburt zu einer hoeheren Tumorinzidenz fuehrt, als ausschliessliche Exposition erwachsener Tiere. Untersuchungen mit anderen nicht gentoxischen Stoffen ergaben unter aehnlichen Bedingungen keinen entsprechenden Befund. Die vorliegenden Daten weisen auf eine hohe Empfindlichkeit des kindlichen Organismus gegenueber bestimmten (gentoxischen) Kanzerogenen hin. Wenn Kinder gegenueber diesen Stoffen exponiert sind, ist deshalb auch bei Exposition ueber kuerzere Zeitraeume ein hohes Krebsrisiko nicht auszuschliessen. (orig.)

  9. Krebs Cycle Moonlights in Caspase Regulation

    OpenAIRE

    Minis, Adi; Steller, Hermann

    2016-01-01

    In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation.

  10. Modelling the Krebs cycle and oxidative phosphorylation.

    Science.gov (United States)

    Korla, Kalyani; Mitra, Chanchal K

    2014-01-01

    The Krebs cycle and oxidative phosphorylation are the two most important sets of reactions in a eukaryotic cell that meet the major part of the total energy demands of a cell. In this paper, we present a computer simulation of the coupled reactions using open source tools for simulation. We also show that it is possible to model the Krebs cycle with a simple black box with a few inputs and outputs. However, the kinetics of the internal processes has been modelled using numerical tools. We also show that the Krebs cycle and oxidative phosphorylation together can be combined in a similar fashion - a black box with a few inputs and outputs. The Octave script is flexible and customisable for any chosen set-up for this model. In several cases, we had no explicit idea of the underlying reaction mechanism and the rate determining steps involved, and we have used the stoichiometric equations that can be easily changed as and when more detailed information is obtained. The script includes the feedback regulation of the various enzymes of the Krebs cycle. For the electron transport chain, the pH gradient across the membrane is an essential regulator of the kinetics and this has been modelled empirically but fully consistent with experimental results. The initial conditions can be very easily changed and the simulation is potentially very useful in a number of cases of clinical importance.

  11. A broken krebs cycle in macrophages

    National Research Council Canada - National Science Library

    O'Neill, Luke A J

    2015-01-01

    ... and an intact Krebs cycle as hallmark metabolic features. It is still not fully understood why these differences occur, or indeed how the metabolic rewiring is regulated. Rapidity of response might be an important reason for the metabolic differences (Ganeshan and Chawla, 2014 ). In M1 macrophages, glycolysis would allow for rapid ATP ...

  12. Krebs Cycle Moonlights in Caspase Regulation.

    Science.gov (United States)

    Minis, Adi; Steller, Hermann

    2016-04-04

    In this issue of Developmental Cell, Aram et al. (2016) identify a mechanism that uses a Krebs cycle protein to control local activation of a ubiquitin ligase complex at the mitochondrial outer membrane for temporally and spatially restricted caspase activation during Drosophila sperm differentiation. Copyright © 2016 Elsevier Inc. All rights reserved.

  13. Sulfate radicals enable a non-enzymatic Krebs cycle precursor

    OpenAIRE

    Keller, Markus A; Kampjut, Domen; Harrison, Stuart A.; Ralser, Markus

    2017-01-01

    The evolutionary origins of the tricarboxylic acid cycle (TCA), or Krebs cycle, are so far unclear. Despite a few years ago, the existence of a simple non-enzymatic Krebs-cycle catalyst has been dismissed ?as an appeal to magic?, citrate and other intermediates have meanwhile been discovered on a carbonaceous meteorite and do interconvert non-enzymatically. To identify the non-enzymatic Krebs cycle catalyst, we used combinatorial, quantitative high-throughput metabolomics to systematically sc...

  14. Krebs cycle rewired for macrophage and dendritic cell effector functions.

    Science.gov (United States)

    Ryan, Dylan Gerard; O'Neill, Luke A J

    2017-10-01

    The Krebs cycle is an amphibolic pathway operating in the mitochondrial matrix of all eukaryotic organisms. In response to proinflammatory stimuli, macrophages and dendritic cells undergo profound metabolic remodelling to support the biosynthetic and bioenergetic requirements of the cell. Recently, it has been discovered that this metabolic shift also involves the rewiring of the Krebs cycle to regulate cellular metabolic flux and the accumulation of Krebs cycle intermediates, notably, citrate, succinate and fumarate. Interestingly, a new role for Krebs cycle intermediates as signalling molecules and immunomodulators that dictate the inflammatory response has begun to emerge. This review will discuss the latest developments in Krebs cycle rewiring and immune cell effector functions, with a particular focus on the regulation of cytokine production. © 2017 Federation of European Biochemical Societies.

  15. Sulfate radicals enable a non-enzymatic Krebs cycle precursor.

    Science.gov (United States)

    Keller, Markus A; Kampjut, Domen; Harrison, Stuart A; Ralser, Markus

    2017-03-13

    The evolutionary origins of the Krebs cycle (tricarboxylic acid cycle) are not currently clear. Despite the existence of a simple non-enzymatic Krebs cycle catalyst being dismissed only a few years ago as 'an appeal to magic', citrate and other intermediates have since been discovered on a carbonaceous meteorite and do interconvert non-enzymatically. To identify a metabolism-like non-enzymatic Krebs cycle catalyst, we used combinatorial, quantitative high-throughput metabolomics to systematically screen iron and sulfate compounds in a reaction mixture that orients on the typical components of Archaean sediment. Krebs cycle intermediates were found to be stable in water and in the presence of most molecule species, including simple iron sulfate minerals. However, in the presence of sulfate radicals generated from peroxydisulfate, the intermediates underwent 24 interconversion reactions. These non-enzymatic reactions covered the critical topology of the oxidative Krebs cycle, the glyoxylate shunt and the succinic-semialdehyde pathway. Assembled in a chemical network, the reactions achieved over 90% carbon recovery. Our results show that a non-enzymatic precursor of the Krebs cycle is biologically sensible, efficient, and forms spontaneously in the presence of sulfate radicals.

  16. The Thermodynamics of the Krebs Cycle and Related Compounds

    Science.gov (United States)

    Miller, Stanley L.; Smith-Magowan, David

    1990-07-01

    A survey is made of the enthalpies of formation, third law entropies and Gibbs energies available for Krebs cycle and related compounds. These include formate, acetate, succinate, fumarate, glycine, alanine, aspartate and glutamate. The potential of the NAD+/NADH couple is recalculated based on the ethanol/acetaldehyde and isopropanol/acetone equilibria. The reported enzyme catalyzed equilibrium constants of the Krebs cycle reactions are evaluated with estimated errors. These 28 equilibria form a network of reactions that is solved by a least squares regression procedure giving Gibbs energies of formation for 21 Krebs cycle and related compounds. They appear to be accurate to ±0.4 kJṡmol-1 for some compounds but ±1 kJṡmol-1 in less favorable cases. This procedure indicates which third law ΔfG and enzyme equilibria are inaccurate, and allows very accurate ΔfG to be determined for compounds related to the Krebs cycle by measuring enzyme equilibrium constants.

  17. Von Kalifornien nach Taxham / Katri Soe

    Index Scriptorium Estoniae

    Soe, Katri, 1971-

    2005-01-01

    Neljas osa magistritööst "Von Kalifornien nach Taxham: Formen und Strukturen der Kommunikation in Peter Handkes Romanen "Der kurze Brief zum langen Abschied" und "In einer dunklen Nacht ging ich aus meinem stillen Haus"" (Tartu, 2000. Juhendaja: Claus Sommerhage)

  18. GPR91: expanding the frontiers of Krebs cycle intermediates.

    Science.gov (United States)

    de Castro Fonseca, Matheus; Aguiar, Carla J; da Rocha Franco, Joao Antônio; Gingold, Rafael N; Leite, M Fatima

    2016-01-12

    Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle. Succinate, for instance, acts as an extracellular ligand by binding to a G-protein coupled receptor, known as GPR91, expressed in kidney, liver, heart, retinal cells and possibly many other tissues, leading to a wide array of physiological and pathological effects. Through GPR91, succinate is involved in functions such as regulation of blood pressure, inhibition of lipolysis in white adipose tissue, development of retinal vascularization, cardiac hypertrophy and activation of stellate hepatic cells by ischemic hepatocytes. Along the current review, these new effects of succinate through GPR91 will be explored and discussed.

  19. Activity of Krebs cycle enzymes in mdx mice.

    Science.gov (United States)

    Comim, Clarissa M; Hoepers, Andreza; Ventura, Letícia; Freiberger, Viviane; Dominguini, Diogo; Mina, Francielle; Mendonça, Bruna P; Scaini, Giselli; Vainzof, Mariz; Streck, Emílio L; Quevedo, João

    2016-01-01

    Duchenne muscular dystrophy (DMD) is a degenerative disease of skeletal, respiratory, and cardiac muscles caused by defects in the dystrophin gene. More recently, brain involvement has been verified. Mitochondrial dysfunction and oxidative stress may underlie the pathophysiology of DMD. In this study we evaluate Krebs cycle enzymes activity in the cerebral cortex, diaphragm, and quadriceps muscles of mdx mice. Cortex, diaphragm, and quadriceps tissues from male dystrophic mdx and control mice were used. We observed increased malate dehydrogenase activity in the cortex; increased malate dehydrogenase and succinate dehydrogenase activities in the diaphragm; and increased citrate synthase, isocitrate dehydrogenase, and malate dehydrogenase activities in the quadriceps of mdx mice. This study showed increased activity of Krebs cycle enzymes in cortex, quadriceps, and diaphragm in mdx mice. © 2015 Wiley Periodicals, Inc.

  20. Imaging after lever transplatation; Bildgebung nach Lebertransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Turetschek, K. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). Abt. fuer Konservative Faecher; Schima, W. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). Abt. fuer Konservative Faecher; Stift, A. [Universitaetsklinik fuer Chirurgie, Wien (Austria); Schober, E. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). Abt. fuer Konservative Faecher; Dock, W. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). Abt. fuer Chirurgische Faecher; Mostbeck, G. [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). Abt. fuer Konservative Faecher

    1997-03-01

    . Material und Methode: Es wurden im eigenen Krankengut die postoperativen Komplikationen nach OLT retrospektiv ausgewertet. Die Duplexsonographie und die Cholangiographie erwiesen sich als die primaeren Untersuchungsmethoden der Wahl zum Nachweis vaskulaerer oder biliaerer Komplikationen. CT, MRI und die Angiographie waren in Problemfaellen wertvolle additive bildgebende Verfahren zur Diagnosesicherung. Ergebnisse: Nach der primaeren Organdysfunktion sind die vaskulaeren Komplikationen als haeufigste Ursache fuer den Verlust des Spendeorgans anzufuehren. Die Thrombose der A. hepatica ist die haeufigste vaskulaere Komplikation mit einer Inzidenz von 4-42%. Galleleaks, -sludge und -strikturen sind haeufige Komplikationen, die letztlich zu einer Dysfunktion des transplantierten Organs fuehren koennen. Biliaere Komplikationen treten gehaeuft in den ersten 3 Monaten auf und erfordern eine interventionelle oder chirurgische Therapie. Da Patienten nach OLT einer immunsuppressiven Therapie unterliegen, sind sie einem erhoehten Risiko einen lymphoproliferativen Tumor zu entwickeln ausgesetzt. Diese Posttransplant-Tumore koennen mit US, CT und MRI ausgezeichnet abgegrenzt werden, erfordern jedoch eine Sicherung der Diagnose durch eine Feinnadelpunktion. Schlussfolgerung: Die postoperative Verlaufskontrolle und der Nachweis von Komplikationen nach OLT ist eine Domaene von Cholangiographie und Duplexsonographie. In Problemfaellen kommen CT, MRI und Angiographie zum Einsatz. (orig.)

  1. Interhemisphärische Interaktionen nach Schlaganfall

    OpenAIRE

    Srulijes, Karin Veronika

    2010-01-01

    Die nach einem Schlaganfall bei Bewegung der paretischen Hand verstärkte Aktivierung der ungeschädigten Hemisphäre wird in einer Hypothese durch plastische Reorganisation homologer Areale in dieser ungeschädigten Hemisphäre erklärt, begünstigt durch eine Reduktion der inhibitorischen Verbindungen von geschädigter zu ungeschädigter Hemisphäre. Eine andere Hypothese postuliert, dass die verstärkte Aktivierung der ungeschädigten Hemisphäre mit einer verstärkten Inhibition dieser auf die geschädi...

  2. 76 FR 77696 - Establishment of the Naches Heights Viticultural Area

    Science.gov (United States)

    2011-12-14

    .... Also, a general Internet search for ``Naches Heights'' produced many hits relating to the geographical... Cascades, deep beds of unique soils formed in the loess pockets on the plateau. The predominant soils on... Naches Heights plateau landform, according to the NRCS web soil survey, has generally deep loess soils...

  3. Diabetesmanagement nach Pankreatektomie // Diabetes treatment after pancreatectomy

    Directory of Open Access Journals (Sweden)

    Weitgasser R

    2016-01-01

    Full Text Available Dependent on morbidity – pancreatectomy due to a benign or malignant disease – and life expectancy of the patient the individual treatment goal has to be determined. Before pancreatectomy is planned the potential for an autologous islet transplantation should be evaluated. After partial pancreatectomy and still sufficient insulin secretion, treatment according to current ADA/EASD consensus recommendations respectively the guidelines of the Austrian Diabetes Association (ÖDG should be planned.brFollowing total pancreatectomy insulin treatment becomes necessary. As in addition to insulin deficiency glucagon secretion is lacking, high blood glucose excursions are predominant and patients after pancreatectomy are endangered for recurrent severe hypoglycaemic reactions. To cope with this situation, a basal-bolus insulin treatment regimen using multiple daily injections or an insulin pump is recommended. To achieve good glycaemic control a comprehensive diabetes education which enables the patient to regulate diet and daily insulin doses adequately is important. Besides frequent blood glucose measurements the use of continuous glucose monitoring systems (CGM may be useful to support diabetes treatment of these patients in daily life. p bKurzfassung: /bIn Abhängigkeit von der Morbidität – handelt es sich um eine benigne oder maligne Ursache für die Pankreasoperation – und die daraus resultierende Lebenserwartung ist das individuelle Diabetes-Therapieziel festzulegen. Bei geplanter Pankreatektomie sollte die präoperative Evaluierung für eine autologe Inselzelltransplantation erwogen werden. Nach partieller Pankreatektomie und verbleibender ausreichender Insulinsekretion ist eine medikamentöse Therapie entsprechend den aktuellen ADA/EASD-Empfehlungen bzw. den Leitlinien der Österreichischen Diabetes-Gesellschaft (ÖDG vorzuschlagen.brNach totaler Pankreatektomie ist immer eine Insulintherapie nötig. Bei zusätzlich zum Insulinmangel

  4. Driving parts of Krebs cycle in reverse through mineral photochemistry.

    Science.gov (United States)

    Zhang, Xiang V; Martin, Scot T

    2006-12-20

    Scenarios for driving the Krebs cycle in reverse in the absence of enzymatic networks have received much attention in the literature of prebiotic evolution because repeated cycling provides a core mechanism for the synthesis of useful biomolecules from carbon dioxide. Here, we show that three of the five reductive steps in the cycle can be driven photochemically at high yield by a ZnS colloid. The results show the conversion of oxaloacetate to malate, fumarate to succinate, and oxoglutarate to oxalosuccinate. The experimental conditions of circumneutral pH and 288 K, as well as the ZnS semiconductor photocatalyst particles (sphalerite), are believed to have been prevalent in the waters of early Earth. These findings therefore both establish and constrain the plausibility of the occurrence of heretofore difficult chemical conversions in prebiotic metabolic systems.

  5. Deficiência das enzimas do ciclo de Krebs

    OpenAIRE

    Silva, Jaquelina Henriques

    2016-01-01

    Trabalho final de mestrado integrado em Medicina, apresentado á Faculdade de Medicina da Universidade de Coimbra Introdução A importância do ciclo dos ácidos tricarboxílicos ou ciclo de Krebs está associada à formação de equivalentes redutores para a produção de energia (ATP) pela fosforilação oxidativa, na mitocôndria. Também tem uma importante ligação com outras vias, fornecendo intermediários importantes para a biossíntese de várias moléculas, tais como ácidos gordos, ami...

  6. Zuwanderung nach Österreich. Integrationspolitische Herausforderungen

    Directory of Open Access Journals (Sweden)

    Heinz Faßmann

    2016-12-01

    Full Text Available ENGLISH: Since the early 1960ies, Austria has become an immigration country against its will. In the beginning, the migration of Guestworkerswas a flexible supplement of the national labour market. Gradually it developed towards a permanent immigration.With the accession to the European Union Austria became a part of the common European migration era. The immigration fromthird countries lost importance, the immigration from other member states gained. Beside, Austria was always a target countryfor asylum seekers. The structural characteristics of the immigrants as well as the historical context showed some changes. Therefore,the integration processes happened differently. While the integration of the immigrants from other member states –especially from Germany – performed conflict – free and quick, the integration of the guestworkers and their descendants proceededonly stepwise. A similar stepwise and long lasting integration process can be expected for the asylum seekers due totheir qualification and their cultural background. Therefore, the cultural diversity will increase and it is not always an enrichmentonly, but also a reason of conflicts about the valid societal perspectives. DEUTSCH: Österreich hat sich seit den 1960er zu einem Einwanderungsland wider Willen entwickelt. Anfangs war die Zuwanderung vonGastarbeiterInnen eine flexible Ergänzung des nationalen Arbeitsmarktes. Nach und nach entwickelte sich daraus aber eine dauerhafteZuwanderung. Mit dem Beitritt zur Europäischen Union wurde Österreich auch Teil eines Europäischen Wanderungsraums.Die Zuwanderung aus den Drittstaaten verlor an Bedeutung, die Zuwanderung aus anderen Mitgliedstaaten der EuropäischenUnion wurde wichtiger. Daneben war Österreich auch immer wieder Aufnahmeland von Asylwerbern. Die strukturellenMerkmale der Zugewanderten und der zeitliche Kontext der Zuwanderung waren ungleich. Daher verliefen auch die Integrationsprozessesehr unterschiedlich. W

  7. In Vivo Detection of Brain Krebs Cycle Intermediate by Hyperpolarized Magnetic Resonance

    National Research Council Canada - National Science Library

    Mishkovsky, Mor; Comment, Arnaud; Gruetter, Rolf

    2012-01-01

    The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo...

  8. Kinetic model of mitochondrial Krebs cycle: unraveling the mechanism of salicylate hepatotoxic effects.

    Science.gov (United States)

    Mogilevskaya, Ekaterina; Demin, Oleg; Goryanin, Igor

    2006-10-01

    This paper studies the effect of salicylate on the energy metabolism of mitochondria using in silico simulations. A kinetic model of the mitochondrial Krebs cycle is constructed using information on the individual enzymes. Model parameters for the rate equations are estimated using in vitro experimental data from the literature. Enzyme concentrations are determined from data on respiration in mitochondrial suspensions containing glutamate and malate. It is shown that inhibition in succinate dehydrogenase and alpha-ketoglutarate dehydrogenase by salicylate contributes substantially to the cumulative inhibition of the Krebs cycle by salicylates. Uncoupling of oxidative phosphorylation has little effect and coenzyme A consumption in salicylates transformation processes has an insignificant effect on the rate of substrate oxidation in the Krebs cycle. It is found that the salicylate-inhibited Krebs cycle flux can be increased by flux redirection through addition of external glutamate and malate, and depletion in external alpha-ketoglutarate and glycine concentrations.

  9. Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy.

    Science.gov (United States)

    Schroeder, Marie A; Atherton, Helen J; Ball, Daniel R; Cole, Mark A; Heather, Lisa C; Griffin, Julian L; Clarke, Kieran; Radda, George K; Tyler, Damian J

    2009-08-01

    The Krebs cycle plays a fundamental role in cardiac energy production and is often implicated in the energetic imbalance characteristic of heart disease. In this study, we measured Krebs cycle flux in real time in perfused rat hearts using hyperpolarized magnetic resonance spectroscopy (MRS). [2-(13)C]Pyruvate was hyperpolarized and infused into isolated perfused hearts in both healthy and postischemic metabolic states. We followed the enzymatic conversion of pyruvate to lactate, acetylcarnitine, citrate, and glutamate with 1 s temporal resolution. The appearance of (13)C-labeled glutamate was delayed compared with that of other metabolites, indicating that Krebs cycle flux can be measured directly. The production of (13)C-labeled citrate and glutamate was decreased postischemia, as opposed to lactate, which was significantly elevated. These results showed that the control and fluxes of the Krebs cycle in heart disease can be studied using hyperpolarized [2-(13)C]pyruvate.

  10. Metals promote sequences of the reverse Krebs cycle.

    Science.gov (United States)

    Muchowska, Kamila B; Varma, Sreejith J; Chevallot-Beroux, Elodie; Lethuillier-Karl, Lucas; Li, Guang; Moran, Joseph

    2017-11-01

    The reverse tricarboxylic acid (rTCA) cycle (also known as the reverse Krebs cycle) is a central anabolic biochemical pathway whose origins are proposed to trace back to geochemistry, long before the advent of enzymes, RNA or cells, and whose imprint remains intimately embedded in the structure of core metabolism. If it existed, a primordial version of the rTCA cycle would necessarily have been catalysed by naturally occurring minerals at the earliest stage of the transition from geochemistry to biochemistry. Here, we report non-enzymatic promotion of multiple reactions of the rTCA cycle in consecutive sequence, whereby 6 of its 11 reactions were promoted by Zn(2+), Cr(3+) and Fe(0) in an acidic aqueous solution. Two distinct three-reaction sequences were achieved under a common set of conditions. Selectivity was observed for reduction reactions producing rTCA cycle intermediates compared with those leading off-cycle. Reductive amination of ketoacids to furnish amino acids was observed under similar conditions. The emerging reaction network supports the feasibility of primitive anabolism in an acidic, metal-rich reducing environment.

  11. Truncation of the krebs cycle during hypoglycemic coma.

    Science.gov (United States)

    Sutherland, Garnette R; Tyson, Randy L; Auer, Roland N

    2008-07-01

    There is a misconception that hypoglycemic nerve cell death occurs easily, and can happen in the absence of coma. In fact, coma is the prerequisite for neuronal death, which occurs via metabolic excitatory amino acid release. The focus on nerve cell death does not explain how most brain neurons and all glia survive. Brain metabolism was interrogated in rats during and following recovery from 40 min of profound hypoglycemia using ex vivo (1)H MR spectroscopy to determine alterations accounting for survival of brain tissue. As previously shown, a time-dependent increase in aspartate was equaled by a reciprocal decrease in glutamate/glutamine. We here show that the kinetics of aspartate formation during the first 30 min (0.36 +/- 0.03 micromol g(-1) min(-1)) are altered such that glutamate, via aspartate aminotransferase, becomes the primary source of carbon when glucose-derived pyruvate is unavailable. Oxaloacetate is produced directly from alpha-ketoglutarate, so that reactions involving the six-carbon intermediates of the tricarboxylic acid cycle are bypassed. These fundamental observations in basic metabolic pathways in effect redraw the tricarboxylic acid cycle from a tricarboxylic to a dicarboxylic acid cycle during hypoglycemia. The basic neurochemical alterations according to the chemical equilibrium of mass action augments flux through a truncated Krebs cycle that continues to turn during hypoglycemic coma. This explains the partial preservation of energy charge and brain cell survival during periods of glucose deficiency.

  12. Real-time assessment of Krebs cycle metabolism using hyperpolarized 13C magnetic resonance spectroscopy

    OpenAIRE

    Schroeder, Marie A.; Atherton, Helen J; Ball, Daniel R; Cole, Mark A; Heather, Lisa C; Griffin, Julian L.; Clarke, Kieran; Radda, George K.; Tyler, Damian J

    2009-01-01

    The Krebs cycle plays a fundamental role in cardiac energy production and is often implicated in the energetic imbalance characteristic of heart disease. In this study, we measured Krebs cycle flux in real time in perfused rat hearts using hyperpolarized magnetic resonance spectroscopy (MRS). [2-13C]Pyruvate was hyperpolarized and infused into isolated perfused hearts in both healthy and postischemic metabolic states. We followed the enzymatic conversion of pyruvate to lactate, acetylcarnitin...

  13. Krebs cycle intermediates regulate DNA and histone methylation: epigenetic impact on the aging process.

    Science.gov (United States)

    Salminen, Antero; Kauppinen, Anu; Hiltunen, Mikko; Kaarniranta, Kai

    2014-07-01

    Many aging theories have proposed that mitochondria and energy metabolism have a major role in the aging process. There are recent studies indicating that Krebs cycle intermediates can shape the epigenetic landscape of chromatin by regulating DNA and histone methylation. A growing evidence indicates that epigenetics plays an important role in the regulation of healthspan but also is involved in the aging process. 2-Oxoglutarate (α-ketoglutarate) is a key metabolite in the Krebs cycle but it is also an obligatory substrate for 2-oxoglutarate-dependent dioxygenases (2-OGDO). The 2-OGDO enzyme family includes the major enzymes of DNA and histone demethylation, i.e. Ten-Eleven Translocation (TETs) and Jumonji C domain containing (JmjC) demethylases. In addition, 2-OGDO members can regulate collagen synthesis and hypoxic responses in a non-epigenetical manner. Interestingly, succinate and fumarate, also Krebs cycle intermediates, are potent inhibitors of 2-OGDO enzymes, i.e. the balance of Krebs cycle reactions can affect the level of DNA and histone methylation and thus control gene expression. We will review the epigenetic mechanisms through which Krebs cycle intermediates control the DNA and histone methylation. We propose that age-related disturbances in the Krebs cycle function induce stochastic epigenetic changes in chromatin structures which in turn promote the aging process. Copyright © 2014 Elsevier B.V. All rights reserved.

  14. Welche Nahrungsergänzungsmittel braucht die Frau nach der Menopause?

    Directory of Open Access Journals (Sweden)

    Zyriax BC

    2012-01-01

    Full Text Available Nahrungsergänzungsmittel wie Vitamine, Mineralien, Omega-3-Fettsäuren und einige weitere Substanzen finden in den westlichen Ländern weite Verbreitung. In Deutschland nehmen 40 % der Frauen 50 Jahre regelmäßig Supplemente in der Absicht ein, eine adäquate Versorgung zu gewährleisten oder chronische Krankheiten zu vermeiden. Die Mehrheit der Verbraucher berät sich nicht mit ihrem Arzt, was zu inadäquater Dosierung, potenziellen Nebenwirkungen und Interaktionen mit Medikamenten führen kann. Im Unterschied zu Medikamenten dürfen Supplemente ohne Nachweis ihrer Wirksamkeit durch klinische Studien vertrieben werden. Bisher ist die Evidenz für die meisten Supplemente unzureichend, um ihre Anwendung zur Prävention von Krebs oder Herz-Kreislauferkrankungen zu empfehlen. Die Daten von Beobachtungsstudien sind widersprüchlich und Informationen aus randomisierten, kontrollierten Studien fehlen. Daher ist der allgemeine Gebrauch von Supplementen im täglichen Leben eine Gratwanderung zwischen Nutzen und Risiko. Hinsichtlich einer Osteoporose-Prophylaxe werden regelmäßige körperliche Aktivität und eine ausreichende Versorgung mit Kalzium aus der Nahrung und gegebenenfalls eine Supplementierung von Vitamin D empfohlen, insbesondere für Frauen nach der Menopause. Weiterhin ist unter älteren Frauen ein Mangel an Vitamin B12 aufgrund ungenügender Versorgung oder atrophischer Gastritis verbreitet. Mehr Information ist zur Einschätzung des Stellenwertes von Omega-3-Fettsäuren und B-Vitaminen zum Erhalt kognitiver Funktionen erforderlich.

  15. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation.

    Science.gov (United States)

    van Weelden, Susanne W H; Fast, Beate; Vogt, Achim; van der Meer, Pieter; Saas, Joachim; van Hellemond, Jaap J; Tielens, Aloysius G M; Boshart, Michael

    2003-04-11

    The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain. Wild type procyclic cells and mutants with targeted deletion of the gene coding for aconitase were derived by synchronous in vitro differentiation from wild type and mutant (Delta aco::NEO/Delta aco::HYG) bloodstream stage parasites, respectively, where aconitase is not expressed and is dispensable. No differences in intracellular levels of glycolytic and Krebs cycle intermediates were found in procyclic wild type and mutant cells, except for citrate that accumulated up to 90-fold in the mutants, confirming the absence of aconitase activity. Surprisingly, deletion of aconitase did not change differentiation nor the growth rate or the intracellular ATP/ADP ratio in those cells. Metabolic studies using radioactively labeled substrates and NMR analysis demonstrated that glucose and proline were not degraded via the Krebs cycle to CO(2). Instead, glucose was degraded to acetate, succinate, and alanine, whereas proline was degraded to succinate. Importantly, there was absolutely no difference in the metabolic products released by wild type and aconitase knockout parasites, and both were for survival strictly dependent on respiration via the mitochondrial electron transport chain. Hence, although the Krebs cycle enzymes are present, procyclic T. brucei do not use Krebs cycle activity for energy generation, but the mitochondrial respiratory chain is essential for survival and growth. We therefore propose a revised model of the energy metabolism of procyclic T. brucei.

  16. Sodium butyrate reverses the inhibition of Krebs cycle enzymes induced by amphetamine in the rat brain.

    Science.gov (United States)

    Valvassori, Samira S; Calixto, Karen V; Budni, Josiane; Resende, Wilson R; Varela, Roger B; de Freitas, Karolina V; Gonçalves, Cinara L; Streck, Emilio L; Quevedo, João

    2013-12-01

    There is increasing interest in the possibility that mitochondrial impairment may play an important role in bipolar disorder (BD). The Krebs cycle is the central point of oxidative metabolism, providing carbon for biosynthesis and reducing agents for generation of ATP. Recently, studies have suggested that histone deacetylase (HDAC) inhibitors may have antimanic effects. The present study aims to investigate the effects of sodium butyrate (SB), a HDAC inhibitor, on Krebs cycle enzymes activity in the brain of rats subjected to an animal model of mania induced by D-amphetamine (D-AMPH). Wistar rats were first given D-AMPH or saline (Sal) for 14 days, and then, between days 8 and 14, rats were treated with SB or Sal. The citrate synthase (CS), succinate dehydrogenase (SDH), and malate dehydrogenase (MDH) were evaluated in the prefrontal cortex, hippocampus, and striatum of rats. The D-AMPH administration inhibited Krebs cycle enzymes activity in all analyzed brain structures and SB reversed D-AMPH-induced dysfunction analyzed in all brain regions. These findings suggest that Krebs cycle enzymes' inhibition can be an important link for the mitochondrial dysfunction seen in BD and SB exerts protective effects against the D-AMPH-induced Krebs cycle enzymes' dysfunction.

  17. Genetic alterations in Krebs cycle and its impact on cancer pathogenesis.

    Science.gov (United States)

    Sajnani, Karishma; Islam, Farhadul; Smith, Robert Anthony; Gopalan, Vinod; Lam, Alfred King-Yin

    2017-04-01

    Cancer cells exhibit alterations in many cellular processes, including oxygen sensing and energy metabolism. Glycolysis in non-oxygen condition is the main energy production process in cancer rather than mitochondrial respiration as in benign cells. Genetic and epigenetic alterations of Krebs cycle enzymes favour the shift of cancer cells from oxidative phosphorylation to anaerobic glycolysis. Mutations in genes encoding aconitase, isocitrate dehydrogenase, succinate dehydrogenase, fumarate hydratase, and citrate synthase are noted in many cancers. Abnormalities of Krebs cycle enzymes cause ectopic production of Krebs cycle intermediates (oncometabolites) such as 2-hydroxyglutarate, and citrate. These oncometabolites stabilize hypoxia inducible factor 1 (HIF1), nuclear factor like 2 (Nrf2), inhibit p53 and prolyl hydroxylase 3 (PDH3) activities as well as regulate DNA/histone methylation, which in turn activate cell growth signalling. They also stimulate increased glutaminolysis, glycolysis and production of reactive oxygen species (ROS). Additionally, genetic alterations in Krebs cycle enzymes are involved with increased fatty acid β-oxidations and epithelial mesenchymal transition (EMT) induction. These altered phenomena in cancer could in turn promote carcinogenesis by stimulating cell proliferation and survival. Overall, epigenetic and genetic changes of Krebs cycle enzymes lead to the production of oncometabolite intermediates, which are important driving forces of cancer pathogenesis and progression. Understanding and applying the knowledge of these mechanisms opens new therapeutic options for patients with cancer. Copyright © 2017 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.

  18. Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry.

    Science.gov (United States)

    Wu, Fei; Minteer, Shelley

    2015-02-02

    It has been hypothesized that the high metabolic flux in the mitochondria is due to the self-assembly of enzyme supercomplexes (called metabolons) that channel substrates from one enzyme to another, but there has been no experimental confirmation of this structure or the channeling. A structural investigation of enzyme organization within the Krebs cycle metabolon was accomplished by in vivo cross-linking and mass spectrometry. Eight Krebs cycle enzyme components were isolated upon chemical fixation, and interfacial residues between mitochondrial malate dehydrogenase, citrate synthase, and aconitase were identified. Using constraint protein docking, a low-resolution structure for the three-enzyme complex was achieved, as well as the two-fold symmetric octamer. Surface analysis showed formation of electrostatic channeling upon protein-protein association, which is the first structural evidence of substrate channeling in the Krebs cycle metabolon. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  19. Unsuspected task for an old team: succinate, fumarate and other Krebs cycle acids in metabolic remodeling.

    Science.gov (United States)

    Bénit, Paule; Letouzé, Eric; Rak, Malgorzata; Aubry, Laetitia; Burnichon, Nelly; Favier, Judith; Gimenez-Roqueplo, Anne-Paule; Rustin, Pierre

    2014-08-01

    Seventy years from the formalization of the Krebs cycle as the central metabolic turntable sustaining the cell respiratory process, key functions of several of its intermediates, especially succinate and fumarate, have been recently uncovered. The presumably immutable organization of the cycle has been challenged by a number of observations, and the variable subcellular location of a number of its constitutive protein components is now well recognized, although yet unexplained. Nonetheless, the most striking observations have been made in the recent period while investigating human diseases, especially a set of specific cancers, revealing the crucial role of Krebs cycle intermediates as factors affecting genes methylation and thus cell remodeling. We review here the recent advances and persisting incognita about the role of Krebs cycle acids in diverse aspects of cellular life and human pathology. Copyright © 2014 Elsevier B.V. All rights reserved.

  20. Kasuistik 3: 49-jähriger Patient mit Zustand nach Ablatio testis links nach Trauma und späterer Ablatio testis rechts nach Seminom

    Directory of Open Access Journals (Sweden)

    Wetterauer U

    2003-01-01

    Full Text Available 49-jähriger Patient, der als Kind ein Hodentrauma links erlitten hatte, was zur Ablatio testis führte. Mit 34 Jahren kam es bei einem organbegrenzten Hodentumor (Seminom zum Verlust des kontralateralen Hodens. Zunächst erfolgte über 4-5 Jahre keine Hormonsubstitution. Der Patient erinnert sich an eine deutlich reduzierte Leistungsfähigkeit und einen Libidoverlust mit depressiven Verstimmungen. Die Muskulatur hätte abgenommen. Gleichzeitig hätten Gelenkbeschwerden bestanden. Eine Diagnostik sei damals nicht erfolgt. Nachdem er dann wieder einen Urologen aufgesucht habe, sei eine Testosteronsubstitution in Form einer Injektion durchgeführt worden. Die bisherige Therapie bestand in der Injektion von Testosteronenantat 250 mg alle 4 Wochen. Hierunter hätte sich die Libido wieder teilweise verbessert. Insbesondere in den ersten zwei Wochen nach Injektion wäre die Libido normal und die Sexualität zufriedenstellend gewesen. Die Muskulatur habe mit zusätzlichem körperlichen Training auch wieder zugenommen. In der dritten Woche nach der i.m.-Injektion ließen die Leistungsfähigkeit und die Libido wieder nach und es traten depressive Verstimmungen auf. Gelegentlich seien Hitzewallungen hinzugekommen.

  1. Krebs cycle dysfunction shapes epigenetic landscape of chromatin: novel insights into mitochondrial regulation of aging process.

    Science.gov (United States)

    Salminen, Antero; Kaarniranta, Kai; Hiltunen, Mikko; Kauppinen, Anu

    2014-07-01

    Although there is a substantial literature that mitochondria have a crucial role in the aging process, the mechanism has remained elusive. The role of reactive oxygen species, mitochondrial DNA injuries, and a decline in mitochondrial quality control has been proposed. Emerging studies have demonstrated that Krebs cycle intermediates, 2-oxoglutarate (also known as α-ketoglutarate), succinate and fumarate, can regulate the level of DNA and histone methylation. Moreover, citrate, also a Krebs cycle metabolite, can enhance histone acetylation. Genome-wide screening studies have revealed that the aging process is linked to significant epigenetic changes in the chromatin landscape, e.g. global demethylation of DNA and histones and increase in histone acetylation. Interestingly, recent studies have revealed that the demethylases of DNA (TET1-3) and histone lysines (KDM2-7) are members of 2-oxoglutarate-dependent dioxygenases (2-OGDO). The 2-OGDO enzymes are activated by oxygen, iron and the major Krebs cycle intermediate, 2-oxoglutarate, whereas they are inhibited by succinate and fumarate. Considering the endosymbiont origin of mitochondria, it is not surprising that Krebs cycle metabolites can control the gene expression of host cell by modifying the epigenetic landscape of chromatin. It seems that age-related disturbances in mitochondrial metabolism can induce epigenetic reprogramming, which promotes the appearance of senescent phenotype and degenerative diseases. Copyright © 2014 Elsevier Inc. All rights reserved.

  2. Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy

    NARCIS (Netherlands)

    Ait-El-Mkadem, Samira; Dayem-Quere, Manal; Gusic, Mirjana; Chaussenot, Annabelle; Bannwarth, Sylvie; François, Bérengère; Genin, Emmanuelle C; Fragaki, Konstantina; Volker-Touw, Catharina L M; Vasnier, Christelle; Serre, Valérie; van Gassen, Koen L I; Lespinasse, Françoise; Richter, Susan; Eisenhofer, Graeme; Rouzier, Cécile; Mochel, Fanny; De Saint-Martin, Anne; Abi Warde, Marie-Thérèse; de Sain-van der Velden, Monique G M; Jans, Judith J M; Amiel, Jeanne; Avsec, Ziga; Mertes, Christian; Haack, Tobias B; Strom, Tim; Meitinger, Thomas; Bonnen, Penelope E; Taylor, Robert W; Gagneur, Julien; van Hasselt, Peter M; Rötig, Agnès; Delahodde, Agnès; Prokisch, Holger; Fuchs, Sabine A; Paquis-Flucklinger, Véronique

    2016-01-01

    MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle. We report bi-allelic pathogenic mutations in MDH2 in three unrelated subjects presenting with early-onset generalized

  3. Krebs cycle metabolon formation: metabolite concentration gradient enhanced compartmentation of sequential enzymes.

    Science.gov (United States)

    Wu, Fei; Pelster, Lindsey N; Minteer, Shelley D

    2015-01-25

    Dynamics of metabolon formation in mitochondria was probed by studying diffusional motion of two sequential Krebs cycle enzymes in a microfluidic channel. Enhanced directional co-diffusion of both enzymes against a substrate concentration gradient was observed in the presence of intermediate generation. This reveals a metabolite directed compartmentation of metabolic pathways.

  4. Metabolism: Part II. The Tricarboxylic Acid (TCA), Citric Acid, or Krebs Cycle.

    Science.gov (United States)

    Bodner, George M.

    1986-01-01

    Differentiates the tricarboxylic acid (TCA) cycle (or Krebs cycle) from glycolysis, and describes the bridge between the two as being the conversion of pyruvate into acetyl coenzyme A. Discusses the eight steps in the TCA cycle, the results of isotopic labeling experiments, and the net effects of the TCA cycle. (TW)

  5. A computational model for the identification of biochemical pathways in the krebs cycle.

    Science.gov (United States)

    Oliveira, Joseph S; Bailey, Colin G; Jones-Oliveira, Janet B; Dixon, David A; Gull, Dean W; Chandler, Mary L

    2003-01-01

    We have applied an algorithmic methodology which provably decomposes any complex network into a complete family of principal subcircuits to study the minimal circuits that describe the Krebs cycle. Every operational behavior that the network is capable of exhibiting can be represented by some combination of these principal subcircuits and this computational decomposition is linearly efficient. We have developed a computational model that can be applied to biochemical reaction systems which accurately renders pathways of such reactions via directed hypergraphs (Petri nets). We have applied the model to the citric acid cycle (Krebs cycle). The Krebs cycle, which oxidizes the acetyl group of acetyl CoA to CO(2) and reduces NAD and FAD to NADH and FADH(2), is a complex interacting set of nine subreaction networks. The Krebs cycle was selected because of its familiarity to the biological community and because it exhibits enough complexity to be interesting in order to introduce this novel analytic approach. This study validates the algorithmic methodology for the identification of significant biochemical signaling subcircuits, based solely upon the mathematical model and not upon prior biological knowledge. The utility of the algebraic-combinatorial model for identifying the complete set of biochemical subcircuits as a data set is demonstrated for this important metabolic process.

  6. The Evolution of the Krebs Cycle: A Promising Subject for Meaningful Learning of Biochemistry

    Science.gov (United States)

    da Costa, Caetano; Galembeck, Eduardo

    2016-01-01

    Evolution has been recognized as a key concept for biologists. To enhance comprehension and motivate biology undergraduates for the contents of central energetic metabolism, we addressed the Krebs cycle structure and functions in an evolutionary view. To this end, we created a study guide that contextualizes the emergence of the cyclic pathway, in…

  7. The Use of an Imagery Mnemonic to Teach the Krebs Cycle

    Science.gov (United States)

    Morisaki, Ryoma; Bon, Charles; Levitt, Jacob O.

    2016-01-01

    The Krebs Cycle is a highly taught biochemical pathway that is traditionally difficult to learn. Twenty-seven undergraduate students were randomized to a rote memorization arm or to a mnemonic arm. They were given a pre-test, then shown a lecture corresponding to their assigned method, and then given an immediate Week 0 post-test and a Week 4…

  8. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation

    NARCIS (Netherlands)

    Weelden, van S.W.H.; Fast, B.; Vogt, A.; Meer, van der P.; Saas, J.; Hellemond, van J.J.; Tielens, A.G.M.; Boshart, M.

    2003-01-01

    The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain. Wild type procyclic cells and mutants with targeted deletion of the gene

  9. THE EVOLUTION OF THE KREBS CYCLE: A PROMISING THEME FOR MEANINGFUL BIOCHEMISTRY LEARNING IN BIOLOGY

    Directory of Open Access Journals (Sweden)

    C. Costa

    2015-08-01

    Full Text Available INTRODUCTION: Evolution has been recognized as a key concept for biologists. In order to motivate biology undergraduates for contents of central energetic metabolism, we addressed the Krebs cycle structure and functions to an evolutionary view. To this end, we created a study guide which contextualizes the emergence of the cyclic pathway, in light of the prokaryotic influence since early Earth anaerobic condition to oxygen rise in atmosphere. OBJECTIVES: The main goal is to highlight the educational potential of the material whose subject is scarcely covered in biochemistry textbooks. MATERIALS AND METHODS: The study guide is composed by three interrelated sections, the problem (Section 1, designed to arouse curiosity, inform and motivate students; an introductory text (Section 2 about life evolution, including early micro-organisms and Krebs cycle emergence, and questions (Section 3 for debate. The activity consisted on a peer discussion session, with instructors tutoring. The questions were designed to foster exchange of ideas in an ever-increasing level of complexity, and cover subjects from early atmospheric conditions to organization of the metabolism along the subsequent geological ages. RESULTS AND DISCUSSION: We noticed that students were engaged and motivated by the task, especially during group discussion. Based on students’ feedbacks and class observations, we learned that the material raised curiosity and stimulated discussion among peers. It brought a historical and purposeful way of dealing with difficult biochemical concepts. CONCLUSIONS: The whole experience suggests that the study guide was a stimulus for broadening comprehension of the Krebs cycle, reinforcing the evolutionary stance as an important theme for biology and biochemistry understanding. On the other hand, we do not underestimate the fact that approaching Krebs cycle from an evolutionary standpoint is a quite complex discussion for the majority of students

  10. Herzrhythmusstörungen bei Kindern nach Stromunfall im Niederspannungsbereich

    OpenAIRE

    Widmann, Eric Thomas

    2016-01-01

    Die Dissertation setzt sich mit den Folgen eines Stromunfalls bei Kindern im Niederspannungsbereich auseinander. Sie untersucht die Inzidenz von Herzrhythmusstörungen und die Notwendigkeit einer kardialen Überwachung. Es wurde auch geprüft, ob bestimmte Faktoren mit einer erhöhten Inzidenz von Herzrhythmusstörungen einhergehen. Für die Arbeit wurden die Patientenakten von 101 Kindern nach Niederspannungsstromunfall retrospektiv ausgewertet. Die Ergebnisse dieser Arbeit wurden in der Diskussio...

  11. Oszillationen der QT-Zeit nach ventrikulären Extrasystolen zur nichtinvasiven Risikostratifizierung von Patienten nach Myokardinfarkt

    OpenAIRE

    Kraus, Martin

    2010-01-01

    Imbalancen im Bereich der autonomen Innervation des Herzens auf Sinusknotenebene zeigen sich anhand des Fehlens der „heart rate variability“ und der „heart rate turbulence“ und werden bereits zur Risikoeinschätzung von KHK-Patienten herangezogen, während Untersuchungen zur autonomen Dysbalance auf Ventrikelebene bisher kaum durchgeführt wurden. Daher war das Ziel dieser Arbeit eine Risikostratifizierung von Patienten nach einem Myokardinfarkt anhand dynamischer Veränderungen der QT-Zeit, zu d...

  12. In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance

    OpenAIRE

    Mishkovsky, Mor; Comment, Arnaud; Gruetter, Rolf

    2012-01-01

    The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observation of a TCA cycle intermediate in intact brain, namely, 2-oxoglutarate, a key biomolecule connecting metabolism to neuronal activity. Our observation reveals important information about in vivo biochemical processes hitherto considered undet...

  13. Kinetic Model of Mitochondrial Krebs Cycle: Unraveling the Mechanism of Salicylate Hepatotoxic Effects

    OpenAIRE

    Mogilevskaya, Ekaterina; Demin, Oleg; Goryanin, Igor

    2006-01-01

    This paper studies the effect of salicylate on the energy metabolism of mitochondria using in silico simulations. A kinetic model of the mitochondrial Krebs cycle is constructed using information on the individual enzymes. Model parameters for the rate equations are estimated using in vitro experimental data from the literature. Enzyme concentrations are determined from data on respiration in mitochondrial suspensions containing glutamate and malate. It is shown that inhibition in succinate d...

  14. Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy.

    Science.gov (United States)

    Ait-El-Mkadem, Samira; Dayem-Quere, Manal; Gusic, Mirjana; Chaussenot, Annabelle; Bannwarth, Sylvie; François, Bérengère; Genin, Emmanuelle C; Fragaki, Konstantina; Volker-Touw, Catharina L M; Vasnier, Christelle; Serre, Valérie; van Gassen, Koen L I; Lespinasse, Françoise; Richter, Susan; Eisenhofer, Graeme; Rouzier, Cécile; Mochel, Fanny; De Saint-Martin, Anne; Abi Warde, Marie-Thérèse; de Sain-van der Velde, Monique G M; Jans, Judith J M; Amiel, Jeanne; Avsec, Ziga; Mertes, Christian; Haack, Tobias B; Strom, Tim; Meitinger, Thomas; Bonnen, Penelope E; Taylor, Robert W; Gagneur, Julien; van Hasselt, Peter M; Rötig, Agnès; Delahodde, Agnès; Prokisch, Holger; Fuchs, Sabine A; Paquis-Flucklinger, Véronique

    2017-01-05

    MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle. We report bi-allelic pathogenic mutations in MDH2 in three unrelated subjects presenting with early-onset generalized hypotonia, psychomotor delay, refractory epilepsy, and elevated lactate in the blood and cerebrospinal fluid. Functional studies in fibroblasts from affected subjects showed both an apparently complete loss of MDH2 levels and MDH2 enzymatic activity close to null. Metabolomics analyses demonstrated a significant concomitant accumulation of the MDH substrate, malate, and fumarate, its immediate precursor in the Krebs cycle, in affected subjects' fibroblasts. Lentiviral complementation with wild-type MDH2 cDNA restored MDH2 levels and mitochondrial MDH activity. Additionally, introduction of the three missense mutations from the affected subjects into Saccharomyces cerevisiae provided functional evidence to support their pathogenicity. Disruption of the Krebs cycle is a hallmark of cancer, and MDH2 has been recently identified as a novel pheochromocytoma and paraganglioma susceptibility gene. We show that loss-of-function mutations in MDH2 are also associated with severe neurological clinical presentations in children. Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.

  15. Krebs cycle enzymes from livers of old mice are differentially regulated by caloric restriction.

    Science.gov (United States)

    Hagopian, Kevork; Ramsey, Jon J; Weindruch, Richard

    2004-08-01

    Krebs cycle enzyme activities and levels of five metabolites were determined from livers of old mice (30 months) maintained either on control or on long-term caloric restriction (CR) diets (28 months). In CR mice, the cycle was divided into two major blocks, the first containing citrate synthase, aconitase and NAD-dependent isocitrate dehydrogenase which showed decreased activities, while the second block, containing the remaining enzymes, displayed increased activity (except for fumarase, which was unchanged). CR also resulted in decreased levels of citrate, glutamate and alpha-ketoglutarate, increased levels of malate, and unchanged levels of aspartate. The alpha-ketoglutarate/glutamate and malate/alpha-ketoglutarate ratios were higher in CR, in parallel with previously reported increases with CR in pyruvate carboxylase activity and glucagon levels, respectively. The results indicate that long-term CR induces a differential regulation of Krebs cycle in old mice and this regulation may be the result of changes in gene expression levels, as well as a complex interplay between enzymes, hormones and other effectors. Truncation of Krebs cycle by CR may be an important adaptation to utilize available substrates for the gluconeogenesis necessary to sustain glycolytic tissues, such as brain.

  16. A Krebs Cycle Component Limits Caspase Activation Rate through Mitochondrial Surface Restriction of CRL Activation.

    Science.gov (United States)

    Aram, Lior; Braun, Tslil; Braverman, Carmel; Kaplan, Yosef; Ravid, Liat; Levin-Zaidman, Smadar; Arama, Eli

    2016-04-04

    How cells avoid excessive caspase activity and unwanted cell death during apoptotic caspase-mediated removal of large cellular structures is poorly understood. We investigate caspase-mediated extrusion of spermatid cytoplasmic contents in Drosophila during spermatid individualization. We show that a Krebs cycle component, the ATP-specific form of the succinyl-CoA synthetase β subunit (A-Sβ), binds to and activates the Cullin-3-based ubiquitin ligase (CRL3) complex required for caspase activation in spermatids. In vitro and in vivo evidence suggests that this interaction occurs on the mitochondrial surface, thereby limiting the source of CRL3 complex activation to the vicinity of this organelle and reducing the potential rate of caspase activation by at least 60%. Domain swapping between A-Sβ and the GTP-specific SCSβ (G-Sβ), which functions redundantly in the Krebs cycle, show that the metabolic and structural roles of A-Sβ in spermatids can be uncoupled, highlighting a moonlighting function of this Krebs cycle component in CRL activation. Copyright © 2016 Elsevier Inc. All rights reserved.

  17. The evolution of the Krebs cycle: A promising subject for meaningful learning of biochemistry.

    Science.gov (United States)

    da Costa, Caetano; Galembeck, Eduardo

    2016-05-06

    Evolution has been recognized as a key concept for biologists. To enhance comprehension and motivate biology undergraduates for the contents of central energetic metabolism, we addressed the Krebs cycle structure and functions in an evolutionary view. To this end, we created a study guide that contextualizes the emergence of the cyclic pathway, in light of the prokaryotic influence since the early anaerobic condition of the Earth to increase oxygen in the atmosphere. The study guide is composed of three interrelated sections: (1) a problem, designed to arouse curiosity, inform and motivate students, (2) a text about life evolution, including early microorganisms and the emergence of the Krebs cycle, and (3) questions for debate. The activity consisted on individual reading and peer discussion based on this written material, under the guidance of the instructors. The questions were designed to foster debate in an ever-increasing level of complexity and to strengthen the main contextual aspects leading to emergence, evolving, and permanency of a complex metabolic pathway. Based on classroom observation, analysis of student's written responses, and individual interviews, we noticed they were engaged and motivated by the task, especially during group discussion. The whole experience suggests that the study guide was a stimulus to broaden the comprehension of the Krebs cycle, reinforcing the evolutionary approach as an important subject for learning purposes. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:288-296, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.

  18. Krebs Roulette: Educative Game as Strategy of learning-teaching process in Biochemistry

    Directory of Open Access Journals (Sweden)

    C. N. Almada

    2010-05-01

    Full Text Available The Biochemistry study is complex and many times is restricted to memorization of theorical contents. The educational game could be an catalytic element, capable to contribute in the process of regaining the student's interest. The aim of this work was to create, apply and evaluate an educative game called “Krebs Roulette”. The game contents were 1 roulette, 3 board cards, 48 question cards and complementary game chips. In an experimental tryout, five students joined the test-play in the presence of a mediator. The game duration was one hour. The students were submitted to an evaluation under Krebs Cycle before and after the game. About the game strategy, the students noticed as positive points: easy to play, didactic, making the learn easier. The evaluation of the quizzes, even with a so small experimental group, indicated a significant increase in the teach-learning process. The achieved results suggest that the game could be used as complementary tool for comprehension of the Krebs Cycle as strategy of learning-teaching in Biochemistry.

  19. Impaired in vivo mitochondrial Krebs cycle activity after myocardial infarction assessed using hyperpolarized magnetic resonance spectroscopy.

    Science.gov (United States)

    Dodd, Michael S; Atherton, Helen J; Carr, Carolyn A; Stuckey, Daniel J; West, James A; Griffin, Julian L; Radda, George K; Clarke, Kieran; Heather, Lisa C; Tyler, Damian J

    2014-11-01

    Myocardial infarction (MI) is one of the leading causes of heart failure. An increasing body of evidence links alterations in cardiac metabolism and mitochondrial function with the progression of heart disease. The aim of this work was to, therefore, follow the in vivo mitochondrial metabolic alterations caused by MI, thereby allowing a greater understanding of the interplay between metabolic and functional abnormalities. Using hyperpolarized carbon-13 ((13)C)-magnetic resonance spectroscopy, in vivo alterations in mitochondrial metabolism were assessed for 22 weeks after surgically induced MI with reperfusion in female Wister rats. One week after MI, there were no detectable alterations in in vivo cardiac mitochondrial metabolism over the range of ejection fractions observed (from 28% to 84%). At 6 weeks after MI, in vivo mitochondrial Krebs cycle activity was impaired, with decreased (13)C-label flux into citrate, glutamate, and acetylcarnitine, which correlated with the degree of cardiac dysfunction. These changes were independent of alterations in pyruvate dehydrogenase flux. By 22 weeks, alterations were also seen in pyruvate dehydrogenase flux, which decreased at lower ejection fractions. These results were confirmed using in vitro analysis of enzyme activities and metabolomic profiles of key intermediates. The in vivo decrease in Krebs cycle activity in the 6-week post-MI heart may represent an early maladaptive phase in the metabolic alterations after MI in which reductions in Krebs cycle activity precede a reduction in pyruvate dehydrogenase flux. Changes in mitochondrial metabolism in heart disease are progressive and proportional to the degree of cardiac impairment. © 2014 American Heart Association, Inc.

  20. Krebs Roulette: Educative Game as Strategy of learning-teaching process in Biochemistry

    OpenAIRE

    C. N. Almada; M. S. Vasconcelos; C . Nunes de Almada; F.W.P. Maia,; Mota, E.F.; D. Fernandes de Melo

    2010-01-01

    The Biochemistry study is complex and many times is restricted to memorization of theorical contents. The educational game could be an catalytic element, capable to contribute in the process of regaining the student's interest. The aim of this work was to create, apply and evaluate an educative game called “Krebs Roulette”. The game contents were 1 roulette, 3 board cards, 48 question cards and complementary game chips. In an experimental tryout, five students joined the test-play in the pres...

  1. Long-term results after fibroid embolization; Langzeitergebnisse nach Myomembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Huelsbeck, S. [Medizinischer Klinikverbund Flensburg, Akademisches Lehrkrankenhaus des Universitaetsklinikums Schleswig-Holstein, Abt. Diagnostische und interventionelle Radiologie/Neuroradiologie, Ev.-Luth. Diakonissenanstalt zu Flensburg, Flensburg (Germany)

    2008-07-15

    Fibroids (leiomyoma) are the most frequent benign tumors of the uterus during female reproductive age. In the case of clinical symptoms, uterine artery embolization (UAE) is a well established treatment option for symptomatic fibroids, resulting in promising long-term results. In order to estimate long-term success after UAE, reduction of fibroids and uterus volume is less important than complete improvement and disappearance of fibroid-related symptoms. In addition to a high technical success rate and a low perioperative complication rate, UAE results in high short-term and long-term patient satisfaction (>87%) and improvement of symptoms (>81%). Candidates for UAE should be informed about potential reinterventions in terms of repeated UAE (up to 18% of cases) or surgical treatment options. (orig.) [German] Myome sind die haeufigsten gutartigen soliden Tumoren des weiblichen Genitaltrakts im reproduktiven Alter. Bei klinischen Beschwerden stellt die Uterusarterienembolisation (UAE) zur Therapie des symptomatischen Uterus myomatosus einen fest etabliertes Verfahren dar, das mit viel versprechenden Langzeitergebnissen aufwarten kann. Im Vordergrund der Abschaetzung eines lang andauernden Therapieerfolgs nach UAE stehen weniger die Volumenreduktion eines dominanten Myoms bzw. des gesamten Uterus nach der Behandlung, sondern vielmehr die Besserung oder das voellige Verschwinden der von der Patientin initial vor der UAE angegebenen (myombedingten) Beschwerden. Neben einer hohen technischen Erfolgsrate und geringen perioperativen Komplikationsrate fuehrt die fachkundig durchgefuehrte UAE sowohl im Kurz- als auch Langzeitverlauf zu einem hohen Mass an Patientenzufriedenheit (>87%), verbunden mit einer deutlichen Symptombesserung (>81%). Ueber eine Reintervention (in bis zu ca. 18% der Faelle) im Sinne einer erneuten UAE oder einer operativen Massnahme sollten die Patientinnen allerdings im Vorfeld aufgeklaert werden. (orig.)

  2. Mitochondrial specialization revealed by single muscle fiber proteomics: focus on the Krebs cycle.

    Science.gov (United States)

    Schiaffino, S; Reggiani, C; Kostrominova, T Y; Mann, M; Murgia, M

    2015-12-01

    We have developed a highly sensitive mass spectrometry-based proteomic workflow to examine the proteome of single muscle fibers. This study revealed significant differences in the mitochondrial proteome of the four major fiber types present in mouse skeletal muscle. Here, we focus on Krebs cycle enzymes and in particular on the differential distribution of the two mitochondrial isocitrate dehydrogenases, IDH2 and IDH3. Type 1/slow fibers contain high levels of IDH2 and relatively low levels of IDH3, whereas fast 2X and 2B fibers show an opposite expression pattern. The findings suggest that in skeletal muscle, IDH2 functions in the forward direction of the Krebs cycle and that substrate flux along the cycle occurs predominantly via IDH2 in type 1 fibers and via IDH3 in 2X and 2B fibers. IDH2-mediated conversion of isocitrate to α-ketoglutarate leads to the generation of NADPH, which is critical to buffering the H2O2 produced by the respiratory chain. Nicotinamide nucleotide transhydrogenase (NNT), the other major mitochondrial enzyme involved in NADPH generation, is also more abundant in type 1 fibers. We suggest that the continuously active type 1 fibers are endowed with a more efficient H2O2 scavenging capacity to cope with the higher levels of reactive oxygen species production. © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  3. Kinetic simulation of malate-aspartate and citrate-pyruvate shuttles in association with Krebs cycle.

    Science.gov (United States)

    Korla, Kalyani; Vadlakonda, Lakshmipathi; Mitra, Chanchal K

    2015-01-01

    In the present work, we have kinetically simulated two mitochondrial shuttles, malate-aspartate shuttle (used for transferring reducing equivalents) and citrate-pyruvate shuttle (used for transferring carbon skeletons). However, the functions of these shuttles are not limited to the points mentioned above, and they can be used in different arrangements to meet different cellular requirements. Both the shuttles are intricately associated with Krebs cycle through the metabolites involved. The study of this system of shuttles and Krebs cycle explores the response of the system in different metabolic environments. Here, we have simulated these subsets individually and then combined them to study the interactions among them and to bring out the dynamics of these pathways in focus. Four antiports and a pyruvate pump were modelled along with the metabolic reactions on both sides of the inner mitochondrial membrane. Michaelis-Menten approach was extended for deriving rate equations of every component of the system. Kinetic simulation was carried out using ordinary differential equation solver in GNU Octave. It was observed that all the components attained steady state, sooner or later, depending on the system conditions. Progress curves and phase plots were plotted to understand the steady state behaviour of the metabolites involved. A comparative analysis between experimental and simulated data show fair agreement thus validating the usefulness and applicability of the model.

  4. Mitochondrial Probe Methyltriphenylphosphonium (TPMP) Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase.

    Science.gov (United States)

    Elkalaf, Moustafa; Tůma, Petr; Weiszenstein, Martin; Polák, Jan; Trnka, Jan

    2016-01-01

    Methyltriphenylphosphonium (TPMP) salts have been widely used to measure the mitochondrial membrane potential and the triphenylphosphonium (TPP+) moiety has been attached to many bioactive compounds including antioxidants to target them into mitochondria thanks to their high affinity to accumulate in the mitochondrial matrix. The adverse effects of these compounds on cellular metabolism have been insufficiently studied and are still poorly understood. Micromolar concentrations of TPMP cause a progressive inhibition of cellular respiration in adherent cells without a marked effect on mitochondrial coupling. In permeabilized cells the inhibition was limited to NADH-linked respiration. We found a mixed inhibition of the Krebs cycle enzyme 2-oxoglutarate dehydrogenase complex (OGDHC) with an estimated IC50 3.93 [3.70-4.17] mM, which is pharmacologically plausible since it corresponds to micromolar extracellular concentrations. Increasing the lipophilic character of the used TPP+ compound further potentiates the inhibition of OGDHC activity. This effect of TPMP on the Krebs cycle ought to be taken into account when interpreting observations on cells and mitochondria in the presence of TPP+ derivatives. Compounds based on or similar to TPP+ derivatives may also be used to alter OGDHC activity for experimental or therapeutic purposes.

  5. Self-organization and fractality in a metabolic processes of the Krebs cycle.

    Science.gov (United States)

    Grytsay, V I; Musatenko, I V

    2013-01-01

    The metabolic processes of the Krebs cycle is studied with the help of a mathematical model. The autocatalytic processes resulting in both the formation of the self-organization in the Krebs cycle and the appearance of a cyclicity of its dynamics are determined. Some structural-functional connections creating the synchronism of an autoperiodic functioning at the transport in the respiratory chain and the oxidative phosphorylation are investigated. The conditions for breaking the synchronization of processes, increasing the multiplicity of cyclicity, and for the appearance of chaotic modes are analyzed. The phase-parametric diagram of a cascade of bifurcations showing the transition to a chaotic mode by the Feigenbaum scenario is obtained. The fractal nature of the revealed cascade of bifurcations is demonstrated. The strange attractors formed as a result of the folding are obtained. The results obtained give the idea of structural-functional connections, due to which the self-organization appears in the metabolism running in a cell. The constructed mathematical model can be applied to the study of the toxic and allergic effects of drugs and various substances on cell metabolism.

  6. Mitochondrial Probe Methyltriphenylphosphonium (TPMP Inhibits the Krebs Cycle Enzyme 2-Oxoglutarate Dehydrogenase.

    Directory of Open Access Journals (Sweden)

    Moustafa Elkalaf

    Full Text Available Methyltriphenylphosphonium (TPMP salts have been widely used to measure the mitochondrial membrane potential and the triphenylphosphonium (TPP+ moiety has been attached to many bioactive compounds including antioxidants to target them into mitochondria thanks to their high affinity to accumulate in the mitochondrial matrix. The adverse effects of these compounds on cellular metabolism have been insufficiently studied and are still poorly understood. Micromolar concentrations of TPMP cause a progressive inhibition of cellular respiration in adherent cells without a marked effect on mitochondrial coupling. In permeabilized cells the inhibition was limited to NADH-linked respiration. We found a mixed inhibition of the Krebs cycle enzyme 2-oxoglutarate dehydrogenase complex (OGDHC with an estimated IC50 3.93 [3.70-4.17] mM, which is pharmacologically plausible since it corresponds to micromolar extracellular concentrations. Increasing the lipophilic character of the used TPP+ compound further potentiates the inhibition of OGDHC activity. This effect of TPMP on the Krebs cycle ought to be taken into account when interpreting observations on cells and mitochondria in the presence of TPP+ derivatives. Compounds based on or similar to TPP+ derivatives may also be used to alter OGDHC activity for experimental or therapeutic purposes.

  7. EFEITO DE INTERMEDIÁRIOS DO CICLO DE KREBS SOBRE ALTERAÇÕES OXIDATIVAS INDUZIDAS POR DIFERENTES AGENTES OXIDANTES

    OpenAIRE

    Robson Luiz Puntel

    2006-01-01

    Dados recentes na literatura têm relatado que alguns intermediários do ciclo de Krebs podem agir como potentes antioxidantes, tanto in vitro, quanto in vivo, em diversos sistemas pró-oxidantes. Porém, o(s) mecanismo(s) através dos qual(is) os intermediários do ciclo de Krebs exercem suas atividades antioxidantes não são completamente entendidas. Considerando a escassez de dados in vitro na literatura a respeito do efeito desses intermediários durante situações de estresse oxidativo, o present...

  8. Philosophische Begleitung für Suche nach «Gottesteilchen»

    CERN Multimedia

    2007-01-01

    Berlin (AP) Der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, will die Suche nach dem mysteriösen Higgs-Teilchen philosophisch begleiten lassen.

  9. 2012 Puget Sound LiDAR Consortium (PSLC) Topographic LiDAR: Upper Naches River, Washington

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Watershed Sciences, Inc. (WSI) collected Light Detection and Ranging (LiDAR) data of the Upper Naches River Valley and Nile Slide area of interest on September 30th,...

  10. Metatheoriebildung in der dialogischen Konfliktbearbeitung – ein konzeptioneller Vorschlag am Beispiel der Konflikttransformation nach Galtung und des Konfliktmanagements nach Glasl und des Integralen Ansatzes nach Wilber

    Directory of Open Access Journals (Sweden)

    Karim Fathi

    2010-07-01

    really integrated Peace and Conflict Researcher should be familiar with epistemological and heuristic contexts, but also metatheoretical and theoretical contexts as well. Abstract - Deutsch Angesichts immer komplexerer Konflikte in der Friedens- und Konfliktforschung (Friedens- und Konfliktforschung sind Metatheorien von Nöten, die diese unübersichtliche Vielfalt unterschiedlicher Methoden zu integrieren vermögen. Im Rahmen des vorliegenden Papers soll hierzu ein konzeptioneller Vorschlag skizziert werden, indem zwei holistische und bekannte Ansätze der mediativen Konfliktbearbeitung in einem integrativen Kontext diskutiert werden:- Der Konfliktmanagement-Ansatz nach Prof. Dr. Friedrich Glasl (2004.- Die Transcend-Methode nach Prof. Dr. Johan Galtung (2000. Den theoretischen Rahmen, auf den sich die Überlegungen dieser Arbeit stützen, liefert der Integrale Ansatz (IA von Ken Wilber (2001 – eine viel diskutierte philosophische „Theorie von Allem“, die im Rahmen der Friedens- und Konfliktforschung jedoch noch weitgehend unberücksichtigt geblieben ist. Daher ist es im Rahmen der Arbeit von weiterem Interesse den IA auf seinen Mehrwert für eine integrierte Friedens- und Konfliktforschung zu untersuchen.Die Untersuchung verlief wie folgt: 1. Vorstellung der in der Untersuchung berücksichtigten Ansätze: a. Der Konfliktmanagement-Ansatz von Glasl unterscheidet eine Vielzahl von Kategorien und Ansatzmomenten, die ein komplexes Interventionsspektrum ergeben. Sehr wichtig ist hierbei unter anderem die Berücksichtigung von Eskalationsstufen, die eine Unterscheidung zwischen perzeptions- (niedrige Eskalation, gefühls- (mittlere Eskalation und verhaltensorientierten (hohe Eskalation Maßnahmen ermöglichen. b. Die Konflikttransformation nach Galtung zeichnet sich unter anderem durch dreigeteilte Schematisierungen aus, die ein komplexes Verständnis von Gewalt (direkt, kulturell, strukturell, Konflikt (Verhalten, Annahmen, Widerspruch und Frieden (Gewaltlosigkeit

  11. In vivo detection of brain Krebs cycle intermediate by hyperpolarized magnetic resonance.

    Science.gov (United States)

    Mishkovsky, Mor; Comment, Arnaud; Gruetter, Rolf

    2012-12-01

    The Krebs (or tricarboxylic acid (TCA)) cycle has a central role in the regulation of brain energy regulation and metabolism, yet brain TCA cycle intermediates have never been directly detected in vivo. This study reports the first direct in vivo observation of a TCA cycle intermediate in intact brain, namely, 2-oxoglutarate, a key biomolecule connecting metabolism to neuronal activity. Our observation reveals important information about in vivo biochemical processes hitherto considered undetectable. In particular, it provides direct evidence that transport across the inner mitochondria membrane is rate limiting in the brain. The hyperpolarized magnetic resonance protocol designed for this study opens the way to direct and real-time studies of TCA cycle kinetics.

  12. Krebs cycle intermediates modulate thiobarbituric acid reactive species (TBARS) production in rat brain in vitro.

    Science.gov (United States)

    Puntel, Robson L; Nogueira, Cristina W; Rocha, João B T

    2005-02-01

    The aim of this study was to investigate the effect of Krebs cycle intermediates on basal and quinolinic acid (QA)- or iron-induced TBARS production in brain membranes. Oxaloacetate, citrate, succinate and malate reduced significantly the basal and QA-induced TBARS production. The potency for basal TBARS inhibition was in the order (IC50 is given in parenthesis as mM) citrate (0.37) > oxaloacetate (1.33) = succinate (1.91) > > malate (12.74). alpha-Ketoglutarate caused an increase in TBARS production without modifying the QA-induced TBARS production. Cyanide (CN-) did not modify the basal or QA-induced TBARS production; however, CN- abolished the antioxidant effects of succinate. QA-induced TBARS production was enhanced by iron ions, and abolished by desferrioxamine (DFO). The intermediates used in this study, except for alpha-ketoglutarate, prevented iron-induced TBARS production. Oxaloacetate, citrate, alpha-ketoglutarate and malate, but no succinate and QA, exhibited significantly iron-chelating properties. Only alpha-ketoglutarate and oxaloacetate protected against hydrogen peroxide-induced deoxyribose degradation, while succinate and malate showed a modest effect against Fe2+/H2O2-induced deoxyribose degradation. Using heat-treated preparations citrate, malate and oxaloacetate protected against basal or QA-induced TBARS production, whereas alpha-ketoglutarate induced TBARS production. Succinate did not offer protection against basal or QA-induced TBARS production. These results suggest that oxaloacetate, malate, succinate, and citrate are effective antioxidants against basal and iron or QA-induced TBARS production, while alpha-ketoglutarate stimulates TBARS production. The mechanism through which Krebs cycle intermediates offer protection against TBARS production is distinct depending on the intermediate used. Thus, under pathological conditions such as ischemia, where citrate concentrations vary it can assume an important role as a modulator of oxidative

  13. [The modification of nitric oxide production by exogenous substrates of Krebs cycle during acute hypoxia].

    Science.gov (United States)

    Kurhaliuk, N M; Kotsiuruba, A V; Sahach, V F

    2005-01-01

    Hypoxia causes the disruption of mitochondria electron respiratory chain, production of active oxygen forms and the unoxidative protection. In experiments on Wistar rats the influence of sodium succinate (50 mg/kg) and 6-ketoglutarate (200 mg/kg) on NO2-, NO3-, urea and polyamines contents in blood and liver under acute hypoxia (7% O2 in N2, 30 min) was investigated. Nitrite and nitrate content decreased in erythrocytes and liver but not in plasma under acute hypoxia. The exogenous succinate (SK) stimulated production of nitric oxide in erythrocytes and liver while 6-ketoglutarate (KG) only in liver. The switch from more intensive SK oxidation that reveals adrenomimetic influence and causes the synthesis and release of NO from erythrocyte, to less intensive KG correlates with well-known decrease of tissue respiration under the activation of the cholinergic system due to urea cycle activation particularly in liver. The activation of the SK oxidation takes place mainly under the different stress conditions and causes NO production in the blood cells. These conditions of the intensive and fast action under acute hypoxia are accompanied on the one hand by the increase of oxygen input ratio and on the other hand by activation of the free radical oxidation. The protective effect of the natural Krebs cycle intermediates--SK and KG in particular, is related to the regulation of NO synthesis and its metabolism in the main organs. These results proved the existence not only metabolite control of NO system by Krebs cycle intermediates, but the existence of the systemic mechanism for the support of the functional state of mitochondria under hypoxia.

  14. VERGLEICH VON WINDTURBINEN UNTERSCHIEDLICHER NENNLEISTUNG NACH VERSCHIEDENEN KRITERIEN

    Directory of Open Access Journals (Sweden)

    Aydoğan ÖZDAMAR

    2001-01-01

    Full Text Available In dieser Arbeit wurde die Antwort auf die Frage gesucht, welche Eigenschaften eine Windturbine in den mittelmaßigen und besseren Windstandorten zur Windstromerzeugung haben soll? Zu dem Zweck wurden 10 unterschiedliche in weltweit eingesetzen Windturbinen mit Nennleistung 500 kW und mehr gewählt und nach verschiedenen Beurteilungskriterien verglichen. Für einen allgemeingültigen, einsatzortunabhängigen Vergleich wurden Windmessungen im August 1999 in 10 m Höhe in İzmir, wo das Windenergiepotantial hoch ist, und in Aydın, wo das Windenergiepotantial mittelmäßig ist, durchgeführt. Mit Hilfe dieser Messergebnisse wurde die von den betrachteten Windturbinen zu produzierende Energiemenge berechnet. Danach wurde die zu produzierende Energiemenge der Windturbinen in 10 m und in 70 m Höhe für 1 Jahr ausgerechnet, wobei die jährlichen Messergebnisse von 2 Stationen der staatlichen Behörde für Stromangelegenheiten nahe der Messorten zur Hilfe genommen. Es wurde dabei vorausgesetz, daß die monatlichen Schwankungen des Windenrgiepotantials in Messorten und in Stationen der staatlichen Behörde für Stromangelegenheiten gleich bleibt. Anschließend wurden die Kennwerte wie Energieeinheitskosten, spezifischer Nennleistungspreis, flächen spezifischer Preis, Rückzahlungszeit der Investitionskosten, Kapazitätsfaktor und Turbinkosten pro Jahreskilowattstunde definiert und berechnet. Letzlich wurden die Windturbinen ausgehend von den berechneten Kennwerten untereinander für beide Messorte verglichen und die Ergebnisse interpretiert.

  15. [Adaptation and validation of the neurological soft sign's scale of Krebs et al. to children].

    Science.gov (United States)

    Halayem, S; Hammami, M; Fakhfakh, R; Gaddour, N; Tabbane, K; Amado, I; Krebs, M-O; Bouden, A

    2017-04-01

    Neurological soft signs (NSS) include anomalies in motor integration, coordination, sensory integration and lateralization and could be endophenotypic markers in autism spectrum disorders (ASD). Their characterization provides a more precise phenotype of ASD and more homogeneous subtypes to facilitate clinical and genetic research. Few scales for NSS have been adapted and validated in children including children with ASD. Our objective was to perform an adaptation to the child of a scale assessing neurological soft signs and a validation study in both general and clinical populations. We have selected the NSS scale of Krebs et al. (2000) already validated in adults. It encompasses 5 dimensions: motor coordination, motor integration, sensory integration, involuntary movement, laterality. After a preliminary study that examined 42 children, several changes have been made to the original version to adapt it to the child and to increase its feasibility, particularly in children with ASD. Then we conducted a validation study by assessing the psychometric properties of this scale in a population of 86 children including 26 children with ASD (DSM 5 Criteria) and 60 typically developing children. Children's ages ranged between 6 and 12 years, and patients and controls were matched for gender, age and intelligence. Patients were assessed using the Autism diagnostic Interview-revised and the Childhood Autism Rating Scale to confirm diagnosis. Typically developing children were assessed using the semi-structured Mini International Neuropsychiatric Interview for Children and Adolescents to eliminate any psychiatric disorder. All children with neurological pathologies (history of cerebral palsy, congenital anomaly of the central nervous system, epilepsy, tuberous sclerosis, neurofibromatosis, antecedent of severe head trauma) and obvious physical deformities or sensory deficits that could interfere with neurological assessment were excluded from the study. Both patients

  16. Targeted Exome Sequencing of Krebs Cycle Genes Reveals Candidate Cancer-Predisposing Mutations in Pheochromocytomas and Paragangliomas.

    Science.gov (United States)

    Remacha, Laura; Comino-Méndez, Iñaki; Richter, Susan; Contreras, Laura; Currás-Freixes, María; Pita, Guillermo; Letón, Rocío; Galarreta, Antonio; Torres-Pérez, Rafael; Honrado, Emiliano; Jiménez, Scherezade; Maestre, Lorena; Moran, Sebastian; Esteller, Manel; Satrústegui, Jorgina; Eisenhofer, Graeme; Robledo, Mercedes; Cascón, Alberto

    2017-10-15

    Purpose: Mutations in Krebs cycle genes are frequently found in patients with pheochromocytomas/paragangliomas. Disruption of SDH, FH or MDH2 enzymatic activities lead to accumulation of specific metabolites, which give rise to epigenetic changes in the genome that cause a characteristic hypermethylated phenotype. Tumors showing this phenotype, but no alterations in the known predisposing genes, could harbor mutations in other Krebs cycle genes.Experimental Design: We used downregulation and methylation of RBP1, as a marker of a hypermethylation phenotype, to select eleven pheochromocytomas and paragangliomas for targeted exome sequencing of a panel of Krebs cycle-related genes. Methylation profiling, metabolite assessment and additional analyses were also performed in selected cases.Results: One of the 11 tumors was found to carry a known cancer-predisposing somatic mutation in IDH1 A variant in GOT2, c.357A>T, found in a patient with multiple tumors, was associated with higher tumor mRNA and protein expression levels, increased GOT2 enzymatic activity in lymphoblastic cells, and altered metabolite ratios both in tumors and in GOT2 knockdown HeLa cells transfected with the variant. Array methylation-based analysis uncovered a somatic epigenetic mutation in SDHC in a patient with multiple pheochromocytomas and a gastrointestinal stromal tumor. Finally, a truncating germline IDH3B mutation was found in a patient with a single paraganglioma showing an altered α-ketoglutarate/isocitrate ratio.Conclusions: This study further attests to the relevance of the Krebs cycle in the development of PCC and PGL, and points to a potential role of other metabolic enzymes involved in metabolite exchange between mitochondria and cytosol. Clin Cancer Res; 23(20); 6315-24. ©2017 AACR. ©2017 American Association for Cancer Research.

  17. Krebs cycle function is required for activation of the Spo0A transcription factor in Bacillus subtilis.

    OpenAIRE

    Ireton, K; Jin, S.; Grossman, A D; Sonenshein, A L

    1995-01-01

    Expression of genes early during sporulation in Bacillus subtilis requires the activity of the transcription factor encoded by spo0A. The active, phosphorylated form of Spo0A is produced through the action of a multicomponent pathway, the phosphorelay. A mutant defective in the first three enzymes of the Krebs citric acid cycle was unable to express early sporulation genes, apparently because of a failure to activate the phosphorelay. Cells that produce an altered Spo0A protein that can be ph...

  18. Lipid oxidation in minced beef meat with added Krebs cycle substrates to stabilise colour.

    Science.gov (United States)

    Yi, G; Grabež, V; Bjelanovic, M; Slinde, E; Olsen, K; Langsrud, O; Phung, V T; Haug, A; Oostindjer, M; Egelandsdal, B

    2015-11-15

    Krebs cycle substrates (KCS) can stabilise the colour of packaged meat by oxygen reduction. This study tested whether this reduction releases reactive oxygen species that may lead to lipid oxidation in minced meat under two different storage conditions. KCS combinations of succinate and glutamate increased peroxide forming potential (PFP, 1.18-1.32 mmol peroxides/kg mince) and thiobarbituric acid reactive substances (TBARS, 0.30-0.38 mg malondialdehyde (MDA) equivalents/kg mince) under low oxygen storage conditions. Both succinate and glutamate were metabolised. Moreover, under high oxygen (75%) storage conditions, KCS combinations of glutamate, citrate and malate increased PFP (from 1.22 to 1.29 mmol peroxides/kg) and TBARS (from 0.37 to 0.40 mg MDA equivalents/kg mince). Only glutamate was metabolised. The KCS combinations that were added to stabilise colour were metabolised during storage, and acted as pro-oxidants that promoted lipid oxidation in both high and low oxygen conditions. Copyright © 2015. Published by Elsevier Ltd.

  19. Off-pathway, oxygen-dependent thiamine radical in the Krebs cycle.

    Science.gov (United States)

    Frank, René A W; Kay, Christopher W M; Hirst, Judy; Luisi, Ben F

    2008-02-06

    The catalytic cofactor thiamine diphosphate is found in many enzymes of central metabolism and is essential in all extant forms of life. We demonstrate the presence of an oxygen-dependent free radical in the thiamine diphosphate-dependent Escherichia coli 2-oxoglutarate dehydrogenase, which is a key component of the tricarboxylic acid (Krebs) cycle. The radical was sufficiently long-lived to be trapped by freezing in liquid nitrogen, and its electronic structure was investigated by electron paramagnetic resonance (EPR) and electron-nuclear double resonance (ENDOR). Taken together, the spectroscopic results revealed a delocalized pi radical on the enamine-thiazolium intermediate within the enzyme active site. The radical is generated as an intermediate during substrate turnover by a side reaction with molecular oxygen, resulting in the continuous production of reactive oxygen species under aerobic conditions. This off-pathway reaction may account for metabolic dysfunction associated with several neurodegenerative diseases. The possibility that the on-pathway reaction may proceed via a radical mechanism is discussed.

  20. A unique hexokinase in Cryptosporidium parvum, an apicomplexan pathogen lacking the Krebs cycle and oxidative phosphorylation.

    Science.gov (United States)

    Yu, Yonglan; Zhang, Haili; Guo, Fengguang; Sun, Mingfei; Zhu, Guan

    2014-09-01

    Cryptosporidium parvum may cause virtually untreatable infections in AIDS patients, and is recently identified as one of the top four diarrheal pathogens in children in developing countries. Cryptosporidium differs from other apicomplexans (e.g., Plasmodium and Toxoplasma) by lacking many metabolic pathways including the Krebs cycle and cytochrome-based respiratory chain, thus relying mainly on glycolysis for ATP production. Here we report the molecular and biochemical characterizations of a hexokinase in C. parvum (CpHK). Our phylogenetic reconstructions indicated that apicomplexan hexokinases including CpHK were highly divergent from those of humans and animals (i.e., at the base of the eukaryotic clade). CpHK displays unique kinetic features that differ from those in mammals and Toxoplasma gondii (TgHK) in the preference towards various hexoses and its capacity to use ATP and other NTPs. CpHK also displays substrate inhibition by ATP. Moreover, 2-deoxy-D-glucose (2DG) could not only inhibit the CpHK activity, but also the parasite growth in vitro at concentrations nontoxic to host cells (IC(50) = 0.54 mM). While the exact action of 2-deoxy-D-glucose on the parasite is subject to further verification, our data suggest that CpHK and the glycolytic pathway may be explored for developing anti-cryptosporidial therapeutics. Copyright © 2014 Elsevier GmbH. All rights reserved.

  1. The krebs cycle enzyme α-ketoglutarate decarboxylase is an essential glycosomal protein in bloodstream African trypanosomes.

    Science.gov (United States)

    Sykes, Steven; Szempruch, Anthony; Hajduk, Stephen

    2015-03-01

    α-Ketoglutarate decarboxylase (α-KDE1) is a Krebs cycle enzyme found in the mitochondrion of the procyclic form (PF) of Trypanosoma brucei. The bloodstream form (BF) of T. brucei lacks a functional Krebs cycle and relies exclusively on glycolysis for ATP production. Despite the lack of a functional Krebs cycle, α-KDE1 was expressed in BF T. brucei and RNA interference knockdown of α-KDE1 mRNA resulted in rapid growth arrest and killing. Cell death was preceded by progressive swelling of the flagellar pocket as a consequence of recruitment of both flagellar and plasma membranes into the pocket. BF T. brucei expressing an epitope-tagged copy of α-KDE1 showed localization to glycosomes and not the mitochondrion. We used a cell line transfected with a reporter construct containing the N-terminal sequence of α-KDE1 fused to green fluorescent protein to examine the requirements for glycosome targeting. We found that the N-terminal 18 amino acids of α-KDE1 contain overlapping mitochondrion- and peroxisome-targeting sequences and are sufficient to direct localization to the glycosome in BF T. brucei. These results suggest that α-KDE1 has a novel moonlighting function outside the mitochondrion in BF T. brucei. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  2. The life-extending gene Indy encodes an exchanger for Krebs-cycle intermediates.

    Science.gov (United States)

    Knauf, Felix; Mohebbi, Nilufar; Teichert, Carsten; Herold, Diana; Rogina, Blanka; Helfand, Stephen; Gollasch, Maik; Luft, Friedrich C; Aronson, Peter S

    2006-07-01

    A longevity gene called Indy (for 'I'm not dead yet'), with similarity to mammalian genes encoding sodium-dicarboxylate cotransporters, was identified in Drosophila melanogaster. Functional studies in Xenopus oocytes showed that INDY mediates the flux of dicarboxylates and citrate across the plasma membrane, but the specific transport mechanism mediated by INDY was not identified. To test whether INDY functions as an anion exchanger, we examined whether substrate efflux is stimulated by transportable substrates added to the external medium. Efflux of [14C]citrate from INDY-expressing oocytes was greatly accelerated by the addition of succinate to the external medium, indicating citrate-succinate exchange. The succinate-stimulated [14C]citrate efflux was sensitive to inhibition by DIDS (4,4'-di-isothiocyano-2,2'-disulphonic stilbene), as demonstrated previously for INDY-mediated succinate uptake. INDY-mediated efflux of [14C]citrate was also stimulated by external citrate and oxaloacetate, indicating citrate-citrate and citrate-oxaloacetate exchange. Similarly, efflux of [14C]succinate from INDY-expressing oocytes was stimulated by external citrate, alpha-oxoglutarate and fumarate, indicating succinate-citrate, succinate-alpha-oxoglutarate and succinate-fumarate exchange respectively. Conversely, when INDY-expressing Xenopus oocytes were loaded with succinate and citrate, [14C]succinate uptake was markedly stimulated, confirming succinate-succinate and succinate-citrate exchange. Exchange of internal anion for external citrate was markedly pH(o)-dependent, consistent with the concept that citrate is co-transported with a proton. Anion exchange was sodium-independent. We conclude that INDY functions as an exchanger of dicarboxylate and tricarboxylate Krebs-cycle intermediates. The effect of decreasing INDY activity, as in the long-lived Indy mutants, may be to alter energy metabolism in a manner that favours lifespan extension.

  3. Evaluation of Krebs cycle enzymes in the brain of rats after chronic administration of antidepressants.

    Science.gov (United States)

    Scaini, Giselli; Santos, Patricia M; Benedet, Joana; Rochi, Natália; Gomes, Lara M; Borges, Lislaine S; Rezin, Gislaine T; Pezente, Daiana P; Quevedo, João; Streck, Emilio L

    2010-05-31

    Several works report brain impairment of metabolism as a mechanism underlying depression. Citrate synthase and succinate dehydrogenase are enzymes localized within cells in the mitochondrial matrix and are important steps of Krebs cycle. In addition, citrate synthase has been used as a quantitative enzyme marker for the presence of intact mitochondria. Thus, we investigated citrate synthase and succinate dehydrogenase activities from rat brain after chronic administration of paroxetine, nortriptiline and venlafaxine. Adult male Wistar rats received daily injections of paroxetine (10mg/kg), nortriptiline (15mg/kg), venlafaxine (10mg/kg) or saline in 1.0mL/kg volume for 15 days. Twelve hours after the last administration, the rats were killed by decapitation, the hippocampus, striatum and prefrontal cortex were immediately removed, and activities of citrate synthase and succinate dehydrogenase were measured. We verified that chronic administration of paroxetine increased citrate synthase activity in the prefrontal cortex, hippocampus, striatum and cerebral cortex of adult rats; cerebellum was not affected. Chronic administration of nortriptiline and venlafaxine did not affect the enzyme activity in these brain areas. Succinate dehydrogenase activity was increased by chronic administration of paroxetine and nortriptiline in the prefrontal cortex, hippocampus, striatum and cerebral cortex of adult rats; cerebellum was not affected either. Chronic administration of venlafaxine increased succinate dehydrogenase activity in prefrontal cortex, but did not affect the enzyme activity in cerebellum, hippocampus, striatum and cerebral cortex. Considering that metabolism impairment is probably involved in the pathophysiology of depressive disorders, an increase in these enzymes by antidepressants may be an important mechanism of action of these drugs. Copyright (c) 2010 Elsevier Inc. All rights reserved.

  4. The Krebs cycle and mitochondrial mass are early victims of endothelial dysfunction: proteomic approach.

    Science.gov (United States)

    Addabbo, Francesco; Ratliff, Brian; Park, Hyeong-Cheon; Kuo, Mei-Chuan; Ungvari, Zoltan; Csiszar, Anna; Ciszar, Anna; Krasnikov, Boris; Krasnikof, Boris; Sodhi, Komal; Zhang, Fung; Nasjletti, Alberto; Goligorsky, Michael S

    2009-01-01

    Endothelial cell dysfunction is associated with bioavailable nitric oxide deficiency and an excessive generation of reactive oxygen species. We modeled this condition by chronically inhibiting nitric oxide generation with subpressor doses of N(G)-monomethyl-L-arginine (L-NMMA) in C57B6 and Tie-2/green fluorescent protein mouse strains. L-NMMA-treated mice exhibited a slight reduction in vasorelaxation ability, as well as detectable abnormalities in soluble adhesion molecules (soluble intercellular adhesion molecule-1 and vascular cellular adhesion molecule-1, and matrix metalloproteinase 9), which represent surrogate indicators of endothelial dysfunction. Proteomic analysis of the isolated microvasculature using 2-dimensional gel electrophoresis and matrix-assisted laser desorption/ionization time-of-flight mass spectroscopy revealed abnormal expression of a cluster of mitochondrial enzymes, which was confirmed using immunodetection. Aconitase-2 and enoyl-CoA-hydratase-1 expression levels were decreased in L-NMMA-treated animals; this phenotype was absent in nitric oxide synthase-1 and -3 knockout mice. Depletion of aconitase-2 and enoyl-CoA-hydratase-1 resulted in the inhibition of the Krebs cycle and enhanced pyruvate shunting toward the glycolytic pathway. To assess mitochondrial mass in vivo, co-localization of green fluorescent protein and MitoTracker fluorescence was detected by intravital microscopy. Quantitative analysis of fluorescence intensity showed that L-NMMA-treated animals exhibited lower fluorescence of MitoTracker in microvascular endothelia as a result of reduced mitochondrial mass. These findings provide conclusive and unbiased evidence that mitochondriopathy represents an early manifestation of endothelial dysfunction, shifting cell metabolism toward "metabolic hypoxia" through the selective depletion of both aconitase-2 and enoyl-CoA-hydratase-1. These findings may contribute to an early preclinical diagnosis of endothelial dysfunction.

  5. Effects of molecular structural variants on serum Krebs von den Lungen-6 levels in sarcoidosis

    Directory of Open Access Journals (Sweden)

    Shigemura Masahiko

    2012-07-01

    Full Text Available Abstract Background Serum Krebs von den Lungen-6 (KL-6, which is classified as human mucin-1 (MUC1, is used as a marker of sarcoidosis and other interstitial lung diseases. However, there remain some limitations due to a lack of information on the factors contributing to increased levels of serum KL-6. This study was designed to investigate the factors contributing to increased levels of serum KL-6 by molecular analysis. Methods Western blot analysis using anti-KL-6 antibody was performed simultaneously on the bronchoalveolar lavage fluid (BALF and serum obtained from 128 subjects with sarcoidosis. Results KL-6/MUC1 in BALF showed three bands and five band patterns. These band patterns were associated with the MUC1 genotype and the KL-6 levels. KL-6/MUC1 band patterns in serum were dependent on molecular size class in BALF. Significantly increased levels of serum KL-6, serum/BALF KL-6 ratio and serum soluble interleukin 2 receptor were observed in the subjects with influx of high molecular size KL-6/MUC1 from the alveoli to blood circulation. The multivariate linear regression analysis involving potentially relevant variables such as age, gender, smoking status, lung parenchymal involvement based on radiographical stage and molecular size of KL-6/MUC1 in serum showed that the molecular size of KL-6/MUC1 in serum was significant independent determinant of serum KL-6 levels. Conclusions The molecular structural variants of KL-6/MUC1 and its leakage behavior affect serum levels of KL-6 in sarcoidosis. This information may assist in the interpretation of serum KL-6 levels in sarcoidosis.

  6. Folgebewertung im vorratsvermögen - Fallstudie zur Vorgehensweise nach IFSR und HGB

    DEFF Research Database (Denmark)

    Quick, Reiner; Warming-Rasmussen, Bent

    2013-01-01

    über die wichstigsten Normen zur Folgebeweriung nach IFSR und HGB sowie zu deren Auslegung. Es schliessen sich ein Fallbeispiel und ein Vorschlag zu dessen Lösung an, in dessen Mittelpunkt sinkende Zeitwerte, die Frage des für die Folgebewerunng relevanten Markts und das Zuschreibungsgebot stehen....

  7. Philosophische Begleitung für Suche nach »Gottesteilchen«

    CERN Multimedia

    2007-01-01

    Berlin_Der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, will die Suche nach dem mysteriösen Higgs-Teilchen philosophisch begleiten lassen. Der Dialog zwischen Naturwissenschaftlern und Philosophen sei wichtig, sagte der Hamburger Experimentalphysiker am Montag im Deutschlandradio Kultur.

  8. 76 FR 30060 - Proposed Establishment of the Naches Heights Viticultural Area (2009R-107P)

    Science.gov (United States)

    2011-05-24

    ... that of the Naches Heights. Soils After the volcanic flow of andesite cooled and hardened to form the..., geology, soils, physical features, and elevation, that make it distinctive and distinguish it from... soils distinguish the proposed viticultural area from the surrounding areas. Geology The petition states...

  9. New functions for parts of the Krebs cycle in procyclic Trypanosoma brucei, a cycle not operating as a cycle.

    Science.gov (United States)

    van Weelden, Susanne W H; van Hellemond, Jaap J; Opperdoes, Fred R; Tielens, Aloysius G M

    2005-04-01

    We investigated whether substrate availability influences the type of energy metabolism in procyclic Trypanosoma brucei. We show that absence of glycolytic substrates (glucose and glycerol) does not induce a shift from a fermentative metabolism to complete oxidation of substrates. We also show that glucose (and even glycolysis) is not essential for normal functioning and proliferation of pleomorphic procyclic T. brucei cells. Furthermore, absence of glucose did not result in increased degradation of amino acids. Variations in availability of glucose and glycerol did result, however, in adaptations in metabolism in such a way that the glycosome was always in redox balance. We argue that it is likely that, in procyclic cells, phosphoglycerate kinase is located not only in the cytosol, but also inside glycosomes, as otherwise an ATP deficit would occur in this organelle. We demonstrate that procyclic T. brucei uses parts of the Krebs cycle for purposes other than complete degradation of mitochondrial substrates. We suggest that citrate synthase plus pyruvate dehydrogenase and malate dehydrogenase are used to transport acetyl-CoA units from the mitochondrion to the cytosol for the biosynthesis of fatty acids, a process we show to occur in proliferating procyclic cells. The part of the Krebs cycle consisting of alpha-ketoglutarate dehydrogenase and succinyl-CoA synthetase was used for the degradation of proline and glutamate to succinate. We also demonstrate that the subsequent enzymes of the Krebs cycle, succinate dehydrogenase and fumarase, are most likely used for conversion of succinate into malate, which can then be used in gluconeogenesis.

  10. Krankengymnastische Frühbehandlung nach Vojta oder nach Bobath: Wie wird die Mutter-Kind-Beziehung beeinflußt?

    OpenAIRE

    Ludewig, Annette; Mähler, Claudia

    1999-01-01

    Die Studie beschäftigt sich mit der Frage nach möglichen Auswirkungen krankengymnastischer Frühbehandlung auf die Mutter-Kind-Beziehung. Mutter-Kind-Paare in Vojta-Behandlung wurden mit solchen in Bobath-Therapie verglichen mit der Erwartung, daß die Vojta-Methode zu stärkerer Belastung der Mutter-Kind-Beziehung beiträgt. Als Indikatoren wurden per Fragebogen die körperliche und seelische Belastung der Mütter sowie ihre Einstellungen zum Kind erhoben. Die Ergebnisse legen nahe, daß insbesonde...

  11. Characterisation of ribosomal proteins from HeLa and Krebs II mouse ascites tumor cells by different two-dimensional polyacrylamide gel electrophoresis techniques

    DEFF Research Database (Denmark)

    Issinger, O G; Beier, H

    1978-01-01

    Electrophoresis of ribosomal proteins according to Kaltschmidt and Wittmann, 1970a, b (pH 8.6/pH 4.5 urea system) yielded 29 proteins for the small subunits and 35 and 37 proteins for the large subunits of Krebs II ascites and HeLa ribosomes, respectively. Analysis of the proteins according...... to a modified technique by Mets and Bogorad (1974) (pH 4.5/pH 8.6 SDS system) revealed 28 and 29 proteins in the small subunits and 37 and 38 proteins in the large subunits of Krebs II ascites and HeLa ribosomes. The molecular weights of the individual proteins were determined by: 1. "three-dimensional" gel...... using the pH 4.5/pH 8.6 SDS system. The molecular weights Krebs II ascites and HeLa ribosomal proteins are compared with those obtained by other authors for different mammalian species....

  12. Dual functions of α-ketoglutarate dehydrogenase E2 in the Krebs cycle and mitochondrial DNA inheritance in Trypanosoma brucei.

    Science.gov (United States)

    Sykes, Steven E; Hajduk, Stephen L

    2013-01-01

    The dihydrolipoyl succinyltransferase (E2) of the multisubunit α-ketoglutarate dehydrogenase complex (α-KD) is an essential Krebs cycle enzyme commonly found in the matrices of mitochondria. African trypanosomes developmentally regulate mitochondrial carbohydrate metabolism and lack a functional Krebs cycle in the bloodstream of mammals. We found that despite the absence of a functional α-KD, bloodstream form (BF) trypanosomes express α-KDE2, which localized to the mitochondrial matrix and inner membrane. Furthermore, α-KDE2 fractionated with the mitochondrial genome, the kinetoplast DNA (kDNA), in a complex with the flagellum. A role for α-KDE2 in kDNA maintenance was revealed in α-KDE2 RNA interference (RNAi) knockdowns. Following RNAi induction, bloodstream trypanosomes showed pronounced growth reduction and often failed to equally distribute kDNA to daughter cells, resulting in accumulation of cells devoid of kDNA (dyskinetoplastic) or containing two kinetoplasts. Dyskinetoplastic trypanosomes lacked mitochondrial membrane potential and contained mitochondria of substantially reduced volume. These results indicate that α-KDE2 is bifunctional, both as a metabolic enzyme and as a mitochondrial inheritance factor necessary for the distribution of kDNA networks to daughter cells at cytokinesis.

  13. Phénotype métabolique des tumeurs associées à des anomalies du cycle de Krebs

    OpenAIRE

    Janin, Maxime

    2015-01-01

    The Krebs cycle has a central role in cellular metabolism and is at the junction of many essential pathways. Since 2000, a link has been shown between the development of particular cancers and mutations affecting genes coding for several Krebs cycle enzymes, i.e., succinate dehydrogenase, fumarase or iso-enzymes 1 and 2 of the isocitrate dehydrogenase (IDH). The IDH mutations are found in 15 to 20 % of acute myeloid leukemias and up to 80% of specific gliomas. These mutations affect the enzym...

  14. Hypokalzämie nach totaler Thyreoidektomie: Welche Patienten sind gefährdet?

    Directory of Open Access Journals (Sweden)

    Kern B

    2010-01-01

    Full Text Available Die Hypokalzämie bedingt durch eine Dysfunktion der Nebenschilddrüsen ist eine mögliche Komplikation nach totaler Thyreoidektomie. Die Inzidenz des passageren Hypoparathyreoidismus liegt bei 8 %, die des permanenten Hypoparathyreoidismus bei 1,5 %. Ursachen sind hauptsächlich die Devaskularisation oder die akzidentielle Entfernung der Nebenschilddrüse intraoperativ. Üblicherweise erfolgen nach totaler Thyreoidektomie repetitive Kalziumkontrollen, um einer symptomatischen Hypokalzämie vorzubeugen. Durch die intraoperative Parathormonmessung können Patienten mit postoperativem Hypoparathyreoidismus frühzeitig erkannt und behandelt werden. Dadurch sind auch immer kürzere Spitalsaufenthalte möglich. Ein postoperatives intaktes Parathormon unterhalb des Normwerts oder ein intraoperativer Abfall 75 % vom Ausgangswert zeigt zuverlässig gefährdete Patienten an, welche prophylaktisch behandelt werden sollten.

  15. Revaskularisierung und Nachweis von Myofibroblasten im freien Sehnentransplantat nach vorderem Kreuzbandersatz

    OpenAIRE

    Unterhauser, Frank Norman

    2004-01-01

    Um das Langzeitüberleben eines Kreuzbandtransplantates nach Ersatz des VKB zu gewährleisten muß das Transplantat revaskularisiert werden. Trotz zahlreicher Studien zu diesem Thema gibt es noch immer eine kontroverse Diskussion bezüglich der Revaskularisierung von Kreuzbandtransplantaten. Ziel der vorliegenden Studie war es die endoligamentäre mikrokapilläre Revaskularisierung eines freien Sehnentransplantates mit Hilfe immunhistochemischer Färbetechnik darzustellen und ihren Verlauf über die ...

  16. Untersuchung zur Eignung eines Gewebeklebers zum Verschluss der Hautwunde bei weiblichen Katzen und Kaninchen nach Kastrationen

    OpenAIRE

    Harre, Daniela

    2012-01-01

    Die Kastration von weiblichen Katzen und Kaninchen ist ein häufig durchgeführter operativer Eingriff in Kleintierpraxen mit einer relativ hohen Inzidenz an möglichen postoperativen Wundheilungskomplikationen. Einen möglichen Einfluss auf die Komplikationsrate hat die Wahl der Methode des Hautwundverschlusses. Ziel dieser Arbeit war es daher, den Wundheilungsverlauf nach Durchführung der Kastration und anschließendem Hautverschluss durch Naht- und Klebetechnik bei zwei unterschiedlichen Tie...

  17. Rückwanderer und Weiterwanderer : ein Aspekt der südkoreanischen Arbeitsmigration nach Deutschland

    OpenAIRE

    Bartmann, Sylke; Garz, Detlef; Lee, Hyo-Seon

    2012-01-01

    "Der Beitrag thematisiert Fragestellungen und Ergebnisse, die in einem internationalen Forschungsprojekt entstanden sind, in dem koreanische und deutsche WissenschaftlerInnen gemeinsam zur südkoreanischen Migration arbeiten. Diskutiert werden zwei mögliche Wege der Migration - die Rück- und Weiterwanderer - als spezifische Formen von Migrationsverläufen. Die Thematisierung wird sowohl mit Blick auf die Migrationsforschung als auch auf die Biographieforschung vollzogen und es wird nach dem Ver...

  18. Comparative glycolysis and Krebs cycle metabolism of the bovine and murine mammary gland determined with [13C6] glucose and mass spectrometry

    Science.gov (United States)

    The compositions of bovine and murine milk differ significantly with respect to the proportions of lactose, protein, and fat. To better understand the metabolic origins of this difference, we interrogated the crossroads of glycolysis and the Krebs cycle in the mammary gland of cows and mice using a ...

  19. Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

    Directory of Open Access Journals (Sweden)

    Kenta Sawa

    2017-03-01

    Full Text Available Krebs cycle intermediates (KCIs are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative stress in neuronal cells. Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. These three intermediates reduced the production of hydrogen peroxide-activated reactive oxygen species, measured in terms of 2′,7′-dichlorofluorescein diacetate fluorescence. In contrast, none of the KCIs—used at 1 mM—protected against cell death induced by high concentrations of glutamate—another type of oxidative stress-induced neuronal cell death. Because these protective KCIs did not have any toxic effects (at least up to 10 mM, they have potential use for therapeutic intervention against chronic neurodegenerative diseases.

  20. Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells.

    Science.gov (United States)

    Sawa, Kenta; Uematsu, Takumi; Korenaga, Yusuke; Hirasawa, Ryuya; Kikuchi, Masatoshi; Murata, Kyohei; Zhang, Jian; Gai, Xiaoqing; Sakamoto, Kazuichi; Koyama, Tomoyuki; Satoh, Takumi

    2017-03-16

    Krebs cycle intermediates (KCIs) are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative stress in neuronal cells. Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. These three intermediates reduced the production of hydrogen peroxide-activated reactive oxygen species, measured in terms of 2',7'-dichlorofluorescein diacetate fluorescence. In contrast, none of the KCIs-used at 1 mM-protected against cell death induced by high concentrations of glutamate-another type of oxidative stress-induced neuronal cell death. Because these protective KCIs did not have any toxic effects (at least up to 10 mM), they have potential use for therapeutic intervention against chronic neurodegenerative diseases.

  1. Extended ischemia prevents HIF1alpha degradation at reoxygenation by impairing prolyl-hydroxylation: role of Krebs cycle metabolites.

    Science.gov (United States)

    Serra-Pérez, Anna; Planas, Anna M; Núñez-O'Mara, Analía; Berra, Edurne; García-Villoria, Judit; Ribes, Antònia; Santalucía, Tomàs

    2010-06-11

    Hypoxia-inducible factor (HIF) is a heterodimeric transcription factor that activates the cellular response to hypoxia. The HIF1alpha subunit is constantly synthesized and degraded under normoxia, but degradation is rapidly inhibited when oxygen levels drop. Oxygen-dependent hydroxylation by prolyl-4-hydroxylases (PHD) mediates HIF1alpha proteasome degradation. Brain ischemia limits the availability not only of oxygen but also of glucose. We hypothesized that this circumstance could have a modulating effect on HIF. We assessed the separate involvement of oxygen and glucose in HIF1alpha regulation in differentiated neuroblastoma cells subjected to ischemia. We report higher transcriptional activity and HIF1alpha expression under oxygen deprivation in the presence of glucose (OD), than in its absence (oxygen and glucose deprivation, OGD). Unexpectedly, HIF1alpha was not degraded at reoxygenation after an episode of OGD. This was not due to impairment of proteasome function, but was associated with lower HIF1alpha hydroxylation. Krebs cycle metabolites fumarate and succinate are known inhibitors of PHD, while alpha-ketoglutarate is a co-substrate of the reaction. Lack of HIF1alpha degradation in the presence of oxygen was accompanied by a very low alpha-ketoglutarate/fumarate ratio. Furthermore, treatment with a fumarate analogue prevented HIF1alpha degradation under normoxia. In all, our data suggest that postischemic metabolic alterations in Krebs cycle metabolites impair HIF1alpha degradation in the presence of oxygen by decreasing its hydroxylation, and highlight the involvement of metabolic pathways in HIF1alpha regulation besides the well known effects of oxygen.

  2. Methylphenidate treatment leads to abnormalities on krebs cycle enzymes in the brain of young and adult rats.

    Science.gov (United States)

    Réus, Gislaine Z; Scaini, Giselli; Furlanetto, Camila B; Morais, Meline O S; Jeremias, Isabela C; Mello-Santos, Lis Mairá; Freitas, Karolina V; Quevedo, João; Streck, Emilio L

    2013-08-01

    Studies have shown a relationship between energy metabolism and methylphenidate (MPH); however, there are no studies evaluating the effects of MPH in Krebs cycle. So, we investigated if MPH treatment could alter the activity of citrate synthase (CS), malate dehydrogenase (MD), and isocitrate dehydrogenase (ID) in the brain of young and adult Wistar rats. Our results showed that MPH (2 and 10 mg/kg) reduced CS in the striatum and prefrontal cortex (PF), with MPH at all doses in the cerebellum and hippocampus after chronic treatment in young rats. In adult rats the CS was reduced in the cerebellum after acute treatment with MPH at all doses, and after chronic treatment in the PF and cerebellum with MPH (10 mg/kg), and in the hippocampus with MPH (2 and 10 mg/kg). The ID decreased in the hippocampus and striatum with MPH (2 and 10 mg/kg), and in the cortex (10 mg/kg) after acute treatment in young rats. In adult rats acute treatment with MPH (2 and 10 mg/kg) reduced ID in the cerebellum, and with MPH (10 mg/kg) in the cortex; chronic treatment with MPH (10 mg/kg) decreased ID in the PF; with MPH (2 and 10 mg/kg) in the cerebellum, and with MPH at all doses in the hippocampus. The MD did not alter. In conclusion, our results suggest that MPH can alter enzymes of Krebs cycle in brain areas involved with circuits related with attention deficit hyperactivity disorder; however, such effects depend on age of animal and treatment regime.

  3. Späte Seed-Migration nach LDR-Brachytherapie der Prostata mit I125-Permanentimplantaten

    Directory of Open Access Journals (Sweden)

    Maletzki P

    2015-01-01

    Full Text Available Hintergrund: Nach einer „Lowdose-rate“- (LDR Brachytherapie der Prostata kommt es häufig zu einer Seed-Migration. Trotz mehrerer Arbeiten über eine Seed-Migration in der frühen postoperativen Phase nach Seed-Implantation gibt es bisher nur wenige Daten über eine Seed-Migration mehrere Jahre nach erfolgter Intervention. Unser Ziel war eine Datenerhebung zur Inzidenz, Lokalisation, Symptomatik und therapeutischen Konsequenz einer späten Seed-Migration 3 Jahre nach Seed-Implantation. Methoden: Wir untersuchten retrospektiv 63 unselektionierte Patienten, die mittels transrektaler, Ultraschall-gesteuerter, transperinealer interstitieller LDR-Brachytherapie der Prostata zwischen 2001 und 2010 behandelt wurden. Es wurden hierbei verknüpfte („stranded“ Seeds verwendet. Am ersten Tag nach der Intervention erfolgte eine Symphysenzielaufnahme und 6 Wochen postoperativ eine erneute Symphysenzielaufnahme in Kombination mit einem CT/MRI des Beckens mit Bildfusionstechnik zur dosimetrischen Untersuchung. Die radiologische Spätkontrolle wurde mehr als 3 Jahre postoperativ mittels einer Symphysenzielaufnahme und eines Thorax-Röntgens durchgeführt. Ergebnisse: Mehr als 3 Jahre nach Brachytherapie zeigten 36 der 63 Patienten (57 % einen Seed-Verlust. Die Anzahl fehlender Seeds lag zwischen 1 und 9. Neben einer frühen Seed-Migration zeigte sich eine späte Seed-Migration bei 2 der 36 Patienten (6 % mit Migration in die Lunge, Leber und das kleine Becken. Alle Spätmigrationen waren asymptomatisch und ohne therapeutische Konsequenz. Diskussion: Neben häufig auftretenden Seed-Verlusten scheint eine Seed-Migration mehrere Jahre nach erfolgter Implantation eine seltene Erscheinung zu sein. Langzeitkontrollen mit ergänzenden radiologischen Nachuntersuchungen könnten dennoch hilfreich zur Dokumentation einer relevanten Seed-Migration sein.

  4. Effect of outdoor and indoor air pollution on lung function, bronchial hyperresponsiveness and risk of pulmonary disease of adults; Langzeitevaluation von Umwelteinfluessen auf Lungenfunktion, bronchiale Hyperreagibilitaet und Krankheitsrisiko von Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Eltschka, R. [Freiburg Univ. (Germany). Zentrum Innere Medizin

    1992-10-01

    The effect of outdoor exposure to SO{sub 2}, NO{sub 2}, particulate pollutants, ozone and pollen on pulmonary function and respiratory discomfort was studied over a period of 1 1/2 yr in 133 no smoking adults at the city of Freiburg. Concentration of indoor and outdoor pollutants were measured. Between January and December 1989 we found in comparison with other large towns low levels of SO{sub 2}, NO{sub 2} and particulate combustion products. The evaluation of individual exposure to air pollutants with lung function measurements shows that participants with essential hyperreactivity demonstrate a significant decrease of the FEV1/IVC - ratio with a threshold value of about 30 {mu}g/m{sup 3} NO{sub 2}. The analyses of the longitudinal study shows a significant correlation between daily peakflow measurements and ozone levels in patients with symptomatic asthma bronchiale and chronic obstructive pulmonary disease. For pollen, SO{sub 2}, NO{sub 2} and anorganic particulate pollutants we did not find any significant effects on peak expiratory flow measurements. (orig./MG) [Deutsch] Der Einfluss von Aussenluftschadstoffen (SO{sub 2}, NO{sub 2}, Staub und Ozon) auf die Lunge wurde in Freiburg in Form einer 1 1/2-jaehrigen Longitudinalstudie bei 133 nicht rauchenden Erwachsenen untersucht. Waehrend des Beobachtungszeitraumes 10/88 - 4/90 erfolgte die Messung der Aussen- und Innenluftschadstoffe. Die Messungen des DW und der LFU zeigen fuer den Zeitraum Januar-Dezember 1989 im Vergleich zu anderen Grossstaedten niedrige Schwefeldioxid-, Stickoxid- und Staubkonzentrationen. Die Querschnittsuntersuchung mit Anamnesefragebogen, Bodyplethysmographie und inhalativem Provokationstest zeigt bei Teilnehmern mit essentieller Hyperreagibilitaet eine signifikante Abnahme des gemessenen und adjustierten Tiffeneau-Index durch NO{sub 2} mit einem Schwellenwert bei 30 {mu}g/m{sup 3}. Die multivariate Analyse der Longitudinalstudie zeigt bei Patienten mit symptomatischem Asthma und

  5. Imaging of postarthroscopic complications after knee injuries; Bildgebung postarthroskopischer Komplikationen nach Knieverletzungen

    Energy Technology Data Exchange (ETDEWEB)

    Schueller-Weidekamm, C. [Medizinische Universitaet Wien, Abteilung fuer Neuroradiologie und muskuloskelettale Radiologie, Klinik fuer Radiodiagnostik, Wien (Austria); Skrbensky, G. von [Medizinische Universitaet Wien, Klinik fuer Orthopaedie, Wien (Austria)

    2012-11-15

    The most common joint injuries in professional and recreational sports participants and also in the total population are knee injuries. Arthroscopy is indicated if this modality will improve the patient outcome and potential long-term complications can be avoided. Although uncommon, complications following arthroscopy are mostly evaluated by magnetic resonance imaging (MRI). For planning further therapy strategies following postarthroscopic complications, e.g. if anterior cruciate ligament (ACL) reconstruction is required, digital radiographs and computed tomography (CT) are helpful. This article provides an overview of the different procedures for surgical treatment which are a prerequisite for the analysis of postarthroscopic images. In addition typical complications after treatment of meniscal and chondral injuries as well as after ACL reconstruction are described and typical signs in MRI, radiography and CT are explained in detail. (orig.) [German] Kniegelenkverletzungen sind nicht nur bei Profisportlern, sondern auch in der Gesamtbevoelkerung die haeufigsten Gelenkverletzungen. Die Indikation zur arthroskopischen Operation wird gestellt, wenn im Vergleich zur konservativen Therapie ein besseres Ergebnis postarthroskopisch zu erwarten ist und potenzielle Spaetkomplikationen verhindert werden koennten. Die selten aber dennoch auftretenden postarthroskopischen Komplikationen werden zumeist mit der Magnetresonanztomographie (MRT) abgeklaert. Zur weiteren Therapieplanung nach Komplikationen, z. B. wenn eine Kreuzbandrevision notwendig ist, sind die digitale Projektionsradiographie und die Computertomographie (CT) hilfreich. Dieser Artikel bietet eine kurze Uebersicht ueber die unterschiedlichen Operationstechniken, die eine Voraussetzung fuer das Verstaendnis der bildgebenden postoperativen Veraenderungen sind. Weiter wird auf die haeufigsten Komplikationen nach Meniskus- und Knorpeloperationen sowie nach vorderer Kreuzbandrekonstruktion und den damit

  6. Die Nachfrage nach Biolebensmitteln in Deutschland : Ökonometrische Analysen zu Nachfragestruktur, Preisbildung und Produktkennzeichnung

    OpenAIRE

    Schröck, Rebecca

    2014-01-01

    Der Biomarkt ist mit einem Umsatzanteil von rund vier Prozent bislang noch ein kleines Segment im deutschen Lebensmittelmarkt – allerdings eines mit großem Nachfrage- und Wachstumspotential. Um das Angebot an den Kundenbedürfnissen ausrichten und das Wachstumspotential ausschöpfen zu können, ist es für alle Akteure auf dem Biomarkt wichtig, die Determinanten der Nachfrage nach Biolebensmitteln zu kennen und das Verhalten der Biokäufer einschätzen zu können. Doch in der wissenschaftlichen Lite...

  7. Einschätzung des PSA-Rezidivs nach kurativer Therapie des Prostatakarzinoms

    Directory of Open Access Journals (Sweden)

    Weißbach L

    2004-01-01

    Full Text Available Das in die Nachsorge kurativ behandelter Patienten mit Prostatakarzinom aufgenommene PSA-Monitoring schafft einen neuen klinischen Status. Wir haben es jetzt mit einem "bio-chemisch Kranken" zu tun, bei dem nicht selten kein lokales Rezidivgeschehen und schon gar nicht eine Fernmetastasierung nachgewiesen werden kann. Um zwischen der lokalen und systemischen Erkrankung unterscheiden zu können, hat man sich früher der "pathohistologischen Prädiktion" bedient. Hierauf beruht auch ein großer Teil der häufig eingesetzten Nomogramme. Mit der Bestimmung der PSA-DT ist eine Methode in das diagnostische Repertoire aufgenommen worden, die nach weiterer Evaluierung dazu dienen könnte, lokale Maßnahmen (RT nach RP oder Salvage-Prostatektomie, HIFU bzw. Kryotherapie oder eine Androgendeprivation vorzunehmen. Vieles deutet darauf hin, daß wir in Zukunft nicht nur mit einer Berechnung der PSA-DT die lokale von der systemischen Progression unterscheiden können, sondern auch das Übergangsstadium zur klinischen Metastasenerkrankung voraussagen und das Risiko, am Prostatakrebs zu sterben, einschätzen können.

  8. Differentiated effect of ageing on the enzymes of Krebs' cycle, electron transfer complexes and glutamate metabolism of non-synaptic and intra-synaptic mitochondria from cerebral cortex.

    Science.gov (United States)

    Villa, R F; Gorini, A; Hoyer, S

    2006-11-01

    The effect of ageing on the activity of enzymes linked to Krebs' cycle, electron transfer chain and glutamate metabolism was studied in three different types of mitochondria of cerebral cortex of 1-year old and 2-year old male Wistar rats. We assessed the maximum rate (V(max)) of the mitochondrial enzyme activities in non-synaptic perikaryal mitochondria, and in two populations of intra-synaptic mitochondria. The results indicated that: (i) in normal, steady-state cerebral cortex the values of the catalytic activities of the enzymes markedly differed in the various populations of mitochondria; (ii) in intra-synaptic mitochondria, ageing affected the catalytic properties of the enzymes linked to Krebs' cycle, electron transfer chain and glutamate metabolism; (iii) these changes were more evident in intra-synaptic "heavy" than "light" mitochondria. These results indicate a different age-related vulnerability of subpopulations of mitochondria in vivo located into synapses than non-synaptic ones.

  9. Metabolismo del Ejercicio; Propuesta didáctica para la enseñanza-aprendizaje de la glucólisis y el ciclo de Krebs

    OpenAIRE

    Ávila Jiménez, Andrés Alberto

    2012-01-01

    Este trabajo presenta una propuesta didáctica para la enseñanza aprendizaje de la Glucólisis y el Ciclo de Krebs del curso de bioquímica dirigido a estudiantes de primer semestre de la carrera de Cinética Humana y Fisioterapia de la Institución Universitaria Iberoamericana, mediante el diseño de una Unidad Didáctica, abordada desde el estudio de la Glucólisis y el Ciclo de Krebs y sus correlación con la fisiología del deporte y el metabolismo del ejercicio, esta diseñada desde el modelo de re...

  10. Intermediates of Krebs cycle correct the depression of the whole body oxygen consumption and lethal cooling in barbiturate poisoning in rat.

    Science.gov (United States)

    Ivnitsky, Jury Ju; Schäfer, Timur V; Malakhovsky, Vladimir N; Rejniuk, Vladimir L

    2004-10-01

    Rats poisoned with one LD50 of thiopental or amytal are shown to increase oxygen consumption when intraperitoneally given sucinate, malate, citrate, alpha-ketoglutarate, dimethylsuccinate or glutamate (the Krebs cycle intermediates or their precursors) but not when given glucose, pyruvate, acetate, benzoate or nicotinate (energy substrates of other metabolic stages etc). Survival was increased with succinate or malate from control groups, which ranged from 30-83% to 87-100%. These effects were unrelated to respiratory depression or hypoxia as judged by little or no effect of succinate on ventilation indices and by the lack of effect of oxygen administration. Body cooling of comatose rats at ambient temperature approximately 19 degrees C became slower with succinate, the rate of cooling correlated well with oxygen consumption decrease. Succinate had no potency to modify oxygen consumption and body temperature in intact rats. A condition for antidote effect of the Krebs intermediate was sufficiently high dosage (5 mmol/kg), further dose increase made no odds. Repeated dosing of succinate had more marked protective effect, than a single one, to oxygen consumption and tended to promote the attenuation of lethal effect of barbiturates. These data suggest that suppression of whole body oxygen consumption with barbiturate overdose could be an important contributor to both body cooling and mortality. Intermediates of Krebs cycle, not only succinate, may have a pronounced therapeutic effect under the proper treatment regimen. Availability of Krebs cycle intermediates may be a limiting factor for the whole body oxygen consumption in barbiturate coma, its role in brain needs further elucidation.

  11. Small RNA-dependent expression of secondary metabolism is controlled by Krebs cycle function in Pseudomonas fluorescens.

    Science.gov (United States)

    Takeuchi, Kasumi; Kiefer, Patrick; Reimmann, Cornelia; Keel, Christoph; Dubuis, Christophe; Rolli, Joëlle; Vorholt, Julia A; Haas, Dieter

    2009-12-11

    Pseudomonas fluorescens CHA0, an antagonist of phytopathogenic fungi in the rhizosphere of crop plants, elaborates and excretes several secondary metabolites with antibiotic properties. Their synthesis depends on three small RNAs (RsmX, RsmY, and RsmZ), whose expression is positively controlled by the GacS-GacA two-component system at high cell population densities. To find regulatory links between primary and secondary metabolism in P. fluorescens and in the related species Pseudomonas aeruginosa, we searched for null mutations that affected central carbon metabolism as well as the expression of rsmY-gfp and rsmZ-gfp reporter constructs but without slowing down the growth rate in rich media. Mutation in the pycAB genes (for pyruvate carboxylase) led to down-regulation of rsmXYZ and secondary metabolism, whereas mutation in fumA (for a fumarase isoenzyme) resulted in up-regulation of the three small RNAs and secondary metabolism in the absence of detectable nutrient limitation. These effects required the GacS sensor kinase but not the accessory sensors RetS and LadS. An analysis of intracellular metabolites in P. fluorescens revealed a strong positive correlation between small RNA expression and the pools of 2-oxoglutarate, succinate, and fumarate. We conclude that Krebs cycle intermediates (already known to control GacA-dependent virulence factors in P. aeruginosa) exert a critical trigger function in secondary metabolism via the expression of GacA-dependent small RNAs.

  12. Inhibition of AMPK and Krebs cycle gene expression drives metabolic remodeling of Pten-deficient preneoplastic thyroid cells.

    Science.gov (United States)

    Antico Arciuch, Valeria G; Russo, Marika A; Kang, Kristy S; Di Cristofano, Antonio

    2013-09-01

    Rapidly proliferating and neoplastically transformed cells generate the energy required to support rapid cell division by increasing glycolysis and decreasing flux through the oxidative phosphorylation (OXPHOS) pathway, usually without alterations in mitochondrial function. In contrast, little is known of the metabolic alterations, if any, which occur in cells harboring mutations that prime their neoplastic transformation. To address this question, we used a Pten-deficient mouse model to examine thyroid cells where a mild hyperplasia progresses slowly to follicular thyroid carcinoma. Using this model, we report that constitutive phosphoinositide 3-kinase (PI3K) activation caused by PTEN deficiency in nontransformed thyrocytes results in a global downregulation of Krebs cycle and OXPHOS gene expression, defective mitochondria, reduced respiration, and an enhancement in compensatory glycolysis. We found that this process does not involve any of the pathways classically associated with the Warburg effect. Moreover, this process was independent of proliferation but contributed directly to thyroid hyperplasia. Our findings define a novel metabolic switch to glycolysis driven by PI3K-dependent AMPK inactivation with a consequent repression in the expression of key metabolic transcription regulators. ©2013 AACR.

  13. S-(2-Succinyl)cysteine: a novel chemical modification of tissue proteins by a Krebs cycle intermediate.

    Science.gov (United States)

    Alderson, Nathan L; Wang, Yuping; Blatnik, Matthew; Frizzell, Norma; Walla, Michael D; Lyons, Timothy J; Alt, Nadja; Carson, James A; Nagai, Ryoji; Thorpe, Suzanne R; Baynes, John W

    2006-06-01

    S-(2-Succinyl)cysteine (2SC) has been identified as a chemical modification in plasma proteins, in the non-mercaptalbumin fraction of human plasma albumin, in human skin collagen, and in rat skeletal muscle proteins and urine. 2SC increases in human skin collagen with age and is increased in muscle protein of diabetic vs. control rats. The concentration of 2SC in skin collagen and muscle protein correlated strongly with that of the advanced glycation/lipoxidation end-product (AGE/ALE), N(epsilon)-(carboxymethyl)lysine (CML). 2SC is formed by a Michael addition reaction of cysteine sulfhydryl groups with fumarate at physiological pH. Fumarate, but not succinate, inactivates the sulfhydryl enzyme, glyceraldehyde-3-phosphate dehydrogenase in vitro, in concert with formation of 2SC. 2SC is the first example of spontaneous chemical modification of protein by a metabolic intermediate in the Krebs cycle. These observations identify fumarate as an endogenous electrophile and suggest a role for fumarate in regulation of metabolism.

  14. Simultaneous investigation of cardiac pyruvate dehydrogenase flux, Krebs cycle metabolism and pH, using hyperpolarized [1,2-(13)C2]pyruvate in vivo.

    Science.gov (United States)

    Chen, Albert P; Hurd, Ralph E; Schroeder, Marie A; Lau, Angus Z; Gu, Yi-ping; Lam, Wilfred W; Barry, Jennifer; Tropp, James; Cunningham, Charles H

    2012-02-01

    (13)C MR spectroscopy studies performed on hearts ex vivo and in vivo following perfusion of prepolarized [1-(13)C]pyruvate have shown that changes in pyruvate dehydrogenase (PDH) flux may be monitored non-invasively. However, to allow investigation of Krebs cycle metabolism, the (13)C label must be placed on the C2 position of pyruvate. Thus, the utilization of either C1 or C2 labeled prepolarized pyruvate as a tracer can only afford a partial view of cardiac pyruvate metabolism in health and disease. If the prepolarized pyruvate molecules were labeled at both C1 and C2 positions, then it would be possible to observe the downstream metabolites that were the results of both PDH flux ((13)CO(2) and H(13)CO(3)(-)) and Krebs cycle flux ([5-(13)C]glutamate) with a single dose of the agent. Cardiac pH could also be monitored in the same experiment, but adequate SNR of the (13)CO(2) resonance may be difficult to obtain in vivo. Using an interleaved selective RF pulse acquisition scheme to improve (13)CO(2) detection, the feasibility of using dual-labeled hyperpolarized [1,2-(13)C(2)]pyruvate as a substrate for dynamic cardiac metabolic MRS studies to allow simultaneous investigation of PDH flux, Krebs cycle flux and pH, was demonstrated in vivo. Copyright © 2011 John Wiley & Sons, Ltd.

  15. Radiation exposure by patients after radionuclide diagnostics or therapy; Strahlenexposition durch Patienten nach nuklearmedizinischer Untersuchung und Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Bockisch, A.; Sonnenschein, W. [Essen Univ. (Gesamthochschule) (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2000-07-01

    The quantitative estimation of the radiation exposure of the population by patients after diagnostic or therapeutic radionuclide application is presented. The paper is based on various published measurements and the recommendation of the German Radiation Savety Committee. The violation of legal limits can only be constructed for physicians performing a high number of sonograms immediately after radionuclide application for bone scans (physician/patient contact time >20 h/a). Otherwise, e.g. if these sonograms are performed after the bone scan, a limit violation may hardly occur. This statement holds for any nuclear medicine procedure particularly also for the child of an investigated mother or vice versa and for nurses. The 1 mSv restriction, on the other hand, can only be met by hospitalisation in the case of radioiodine therapy. (orig.) [German] Die quantitative Abschaetzung der Strahlenexposition der Bevoelkerung durch Patienten nach diagnostischen oder therapeutischen nuklearmedizinischen Massnahmen wird vorgestellt. Der Artikel stuetzt sich dabei auf verschiedene Messungen, die in der Literatur beschrieben sind, sowie auf Empfehlungen der Strahlenschutzkommission, denen Rechnungen und Messungen zugrunde liegen. Demnach lassen sich Grenzwertueberschreitungen, verursacht durch Patienten nach nuklearmedizinischer Diagnostik, lediglich fuer den Fall konstruieren, dass ein Arzt abdominelle Sonographien bei einer hohen Zahl von Patienten (>20 h Kontaktzeit mit den Patienten/Jahr) unmittelbar nach Tracer-Applikation fuer die Skelettszintigraphie durchfuehrt. Ansonsten, beispielsweise auch wenn die Sonographien nach der Szintigraphie erfolgen, ist ein Erreichen der 1 mSv-Grenze kaum moeglich. Dies gilt fuer jegliche Untersuchungsart insbesondere auch fuer das Kind einer untersuchten Mutter oder umgekehrt oder fuer das Pflegepersonal. Die Einhaltung der 1 mSv-Grenze nach Radioiodtherapie ist dagegen nur bei stationaerer Therapie moeglich. (orig.)

  16. Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.

    Science.gov (United States)

    Richter, Susan; Peitzsch, Mirko; Rapizzi, Elena; Lenders, Jacques W; Qin, Nan; de Cubas, Aguirre A; Schiavi, Francesca; Rao, Jyotsna U; Beuschlein, Felix; Quinkler, Marcus; Timmers, Henri J; Opocher, Giuseppe; Mannelli, Massimo; Pacak, Karel; Robledo, Mercedes; Eisenhofer, Graeme

    2014-10-01

    Mutations of succinate dehydrogenase A/B/C/D genes (SDHx) increase susceptibility to development of pheochromocytomas and paragangliomas (PPGLs), with particularly high rates of malignancy associated with SDHB mutations. We assessed whether altered succinate dehydrogenase product-precursor relationships, manifested by differences in tumor ratios of succinate to fumarate or other metabolites, might aid in identifying and stratifying patients with SDHx mutations. PPGL tumor specimens from 233 patients, including 45 with SDHx mutations, were provided from eight tertiary referral centers for mass spectrometric analyses of Krebs cycle metabolites. Diagnostic performance of the succinate:fumarate ratio for identification of pathogenic SDHx mutations. SDH-deficient PPGLs were characterized by 25-fold higher succinate and 80% lower fumarate, cis-aconitate, and isocitrate tissue levels than PPGLs without SDHx mutations. Receiver-operating characteristic curves for use of ratios of succinate to fumarate or to cis-aconitate and isocitrate to identify SDHx mutations indicated areas under curves of 0.94 to 0.96; an optimal cut-off of 97.7 for the succinate:fumarate ratio provided a diagnostic sensitivity of 93% at a specificity of 97% to identify SDHX-mutated PPGLs. Succinate:fumarate ratios were higher in both SDHB-mutated and metastatic tumors than in those due to SDHD/C mutations or without metastases. Mass spectrometric-based measurements of ratios of succinate:fumarate and other metabolites in PPGLs offer a useful method to identify patients for testing of SDHx mutations, with additional utility to quantitatively assess functionality of mutations and metabolic factors responsible for malignant risk.

  17. Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.

    Science.gov (United States)

    Marin-Valencia, Isaac; Cho, Steve K; Rakheja, Dinesh; Hatanpaa, Kimmo J; Kapur, Payal; Mashimo, Tomoyuki; Jindal, Ashish; Vemireddy, Vamsidhara; Good, Levi B; Raisanen, Jack; Sun, Xiankai; Mickey, Bruce; Choi, Changho; Takahashi, Masaya; Togao, Osamu; Pascual, Juan M; Deberardinis, Ralph J; Maher, Elizabeth A; Malloy, Craig R; Bachoo, Robert M

    2012-10-01

    It has been hypothesized that increased flux through the pentose phosphate pathway (PPP) is required to support the metabolic demands of rapid malignant cell growth. Using orthotopic mouse models of human glioblastoma (GBM) and renal cell carcinoma metastatic to brain, we estimated the activity of the PPP relative to glycolysis by infusing [1,2-(13) C(2) ]glucose. The [3-(13) C]lactate/[2,3-(13) C(2) ]lactate ratio was similar for both the GBM and brain metastasis and their respective surrounding brains (GBM, 0.197 ± 0.011 and 0.195 ± 0.033, respectively (p = 1); metastasis: 0.126 and 0.119 ± 0.033, respectively). This suggests that the rate of glycolysis is significantly greater than the PPP flux in these tumors, and that the PPP flux into the lactate pool is similar in both tumors. Remarkably, (13) C-(13) C coupling was observed in molecules derived from Krebs cycle intermediates in both tumor types, denoting glucose oxidation. In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool. In addition, the orthotopic renal tumor, the patient's primary renal mass and brain metastasis were all strongly immunopositive for the 67-kDa isoform of glutamate decarboxylase, as were 84% of tumors on a renal cell carcinoma tissue microarray of the same histology, suggesting that GABA synthesis is cell autonomous in at least a subset of renal cell carcinomas. Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy. Copyright © 2012 John Wiley & Sons, Ltd.

  18. Manganese ions enhance mitochondrial H2O2emission from Krebs cycle oxidoreductases by inducing permeability transition.

    Science.gov (United States)

    Bonke, Erik; Siebels, Ilka; Zwicker, Klaus; Dröse, Stefan

    2016-10-01

    Manganese-induced toxicity has been linked to mitochondrial dysfunction and an increased generation of reactive oxygen species (ROS). We could recently show in mechanistic studies that Mn 2+ ions induce hydrogen peroxide (H 2 O 2 ) production from the ubiquinone binding site of mitochondrial complex II (II Q ) and generally enhance H 2 O 2 formation by accelerating the rate of superoxide dismutation. The present study with intact mitochondria reveals that manganese additionally enhances H 2 O 2 emission by inducing mitochondrial permeability transition (mPT). In mitochondria fed by NADH-generating substrates, the combination of Mn 2+ and different respiratory chain inhibitors led to a dynamically increasing H 2 O 2 emission which was sensitive to the mPT inhibitor cyclosporine A (CsA) as well as Ru-360, an inhibitor of the mitochondrial calcium uniporter (MCU). Under these conditions, flavin-containing enzymes of the mitochondrial matrix, e.g. the mitochondrial 2-oxoglutaratedehydrogenase (OGDH), were major sources of ROS. With succinate as substrate, Mn 2+ stimulated ROS production mainly at complex II, whereby the applied succinate concentration had a marked effect on the tendency for mPT. Also Ca 2+ increased the rate of H 2 O 2 emission by mPT, while no direct effect on ROS-production of complex II was observed. The present study reveals a complex scenario through which manganese affects mitochondrial H 2 O 2 emission: stimulating its production from distinct sites (e.g. site II Q ), accelerating superoxide dismutation and enhancing the emission via mPT which also leads to the loss of soluble components of the mitochondrial antioxidant systems and favors the ROS production from flavin-containing oxidoreductases of the Krebs cycle. Copyright © 2016 Elsevier Inc. All rights reserved.

  19. Pelvic insufficiency fractures after radiotherapy of gynecologic tumors; Osteoradionekrose nach Strahlentherapie gynaekologischer Tumoren

    Energy Technology Data Exchange (ETDEWEB)

    Hoeller, U.; Hoecht, S.; Hinkelbein, W. [Freie Univ. Berlin (Germany). Universitaetsklinikum Benjamin Franklin, Abt. fuer Strahlentherapie; Wudel, E. [Freie Univ. Berlin (Germany). Universitaetsklinikum Benjamin Franklin, Abt. fuer Radiologie und Nuklearmedizin

    2001-06-01

    13 Patientinnen zusaetzlich eine Osteodensitometrie. Die Patientinnen waren adjuvant (n=29) bzw. primaer (n=18) ueber opponierende Felder mit 18-MeV-Photonen mit 46 Gy und Brachytherapie (15-39 Gy) bestrahlt worden. Die mediane Nachbeobachtungszeit betrug 36 Monate. Ergebnisse: Bei sieben Patientinnen trat eine Osteoradionekrose median 11 Monate nach Therapie (minimal 2 Monate) auf. Bei allen Patientinnen traten maessige bis starke Schmerzen im Beckenring auf, die bei fuenf Patientinnen ohne spezifische Therapie nach 5-28 Monaten ganz/teilweise reversibel waren. Bei Erstuntersuchung zeigten sich mit einer Ausnahme szintigraphisch starke Anreicherungen im Ileosakralgelenk und/oder Os sacrum, die mit Infraktionen (CT) korrelierten. Bei den 40 zeitgleich behandelten Patientinnen traten keine Schmerzen, keine intensiven, aber vier maessiggradige szintigraphische Mehranreicherungen (CT unauffaellig) im Feld auf. Drei von vier untersuchten Patientinnen mit Osteoradionekrosen hatte eine Osteoporose im Vergleich zu sieben von neun untersuchten Patientinnen ohne Osteoradionekrosen. Schlussfolgerung: Im Beckenbereich koennen lumbosakraler Schmerz und Sklerose/Fraktur auf eine Osteoradionekrose hinweisen, die schon im ersten Jahr nach Therapie manifest werden kann und von einer ossaeren Metastasierung differenziert werden sollte. (orig.)

  20. Focal neuropathies following percutaneous nephrolithotomy (PCNL – preliminary study [Fokale Neuropathien nach perkutaner Nephrolithotomie (PCNL

    Directory of Open Access Journals (Sweden)

    Kalantari, Behnam Behmardi

    2013-06-01

    Full Text Available [english] Introduction: Postoperative neurological complications in pelvic and renal surgery are a well-known clinical problem and their morbidities are important. We designed this study to determine prevalence and risk factors of such complications after percutaneous nephrolithotomy (PCNL surgery.Material and methods: A cross-sectional study was performed during February and July 2011 on 68 PCNL cases. Demographic data and surgery reports were gathered and comprehensive neurological physical examination carried out before and after surgery. Then, data was analyzed using software SPSS 18. Results: The ultimate sample included 30 (46.2% male and 35 (53.8% female patients with a mean age of 47.9 ± 11.47 years. In intercostal and lumbosacral plexus area, sensory neurological complications occurred in 8 patients (12.31%, 4 men and 4 women. The most common involved dermatomes and nerves were T12 (8 cases. There was a significant correlation between prolonged duration of surgery and prevalence of sensory complications (p[german] Einleitung: Postoperative neurologische Komplikationen bei operativem Eingriff an Becken und Niere sind ein bekanntes klinisches Problem und deren Krankheitsverläufe sind wichtig. Wir planten diese Studie, um die Prävalenz und die Risikofaktoren derartiger Komplikationen nach perkutaner Nephrolithotomie (PCNL zu erfassen.Material und Methoden: Von Februar bis Juli 2011 wurde eine Querschnittstudie an 68 PCNL-Fällen durchgeführt. Die demographischen Daten und die Operationsberichte wurden ausgewertet und umfassende neurologische und körperliche Untersuchungen wurden vor und nach dem chirurgischen Eingriff vorgenommen. Die Daten wurden mit der Software SPSS 18 analysiert.Ergebnisse: In die Studie einbezogen wurden 30 männliche (46,2% und 35 (53,8% weibliche Patienten mit einem mittleren Alter von 47,9 ± 11,47 Jahren. Bei 8 Patienten (12,31%, bei 4 Männern und 4 Frauen, wurden im Bereich des interkostalen und

  1. Das Répertoire International des Sources Musicales (RISM nach Fünfzig Jahren

    Directory of Open Access Journals (Sweden)

    Heckmann, Harald

    2001-12-01

    Full Text Available In 1952, a Commission Mixte formed by members of the International Musicological Society (IMS and the International Association of Music Libraries (lAML constituted in Paris the Répertoire International des Sources Musicales (RISM. In 1971, the first two volumes appeared - the Écrits imprimés concernant la musique edited by François Lesure. In 1960, a central editorial office (Zentralredaktion was founded in Kassel for the Series of the Einzeldrucke vor 1800/Single Prints before 1800. Consisting of 13 volumes, this is now complete with the exception of an index. Since moving to Frankfurt am Main in 1987, the Zentralredaktion has concentrated its work on the Handschriften nach 1600/Manuscripts after 1600. Because of its scope, this project presented RISM with an enormous challenge and, therefore, digitalization was a very early priority. In 1995, the first CD-ROM with the RISM manuscript database appeared followed each year by a cumulative edition; the sixth CD appeared at the end of 2000 containing about 350,000 entries from 575 libraries in 31 countries. Looking at what has been achieved in the last 50 years and taking into account the Series of special catalogs, now expanded to 29 printed volumes, the result deserves respect. There are, however, gaps. These include the fact that in some countries with an especially rich tradition, sources not yet accessible will have to be integrated into the RISM catalog. Spain is such a country and F. Gonzalez Valle has rendered great service in making these sources accessible. His pupils and successors are called upon to mobilize all forces so that within the international RISM community Spain takes up the place appropriate to its past and present rich musical culture.[de] 1952 konstituierte eine Commission Mixte aus Mitgliedern der Internationalen Gesellschaft fur Musikwissenschaft (IGMW und der Internationalen Vereinigung der Musikbibliotheken (IVMB in Paris das Répertoire International des Sources

  2. NaDC3 Induces Premature Cellular Senescence by Promoting Transport of Krebs Cycle Intermediates, Increasing NADH, and Exacerbating Oxidative Damage.

    Science.gov (United States)

    Ma, Yuxiang; Bai, Xue-Yuan; Du, Xuan; Fu, Bo; Chen, Xiangmei

    2016-01-01

    High-affinity sodium-dependent dicarboxylate cotransporter 3 (NaDC3) is a key metabolism-regulating membrane protein responsible for transport of Krebs cycle intermediates. NaDC3 is upregulated as organs age, but knowledge regarding the underlying mechanisms by which NaDC3 modulates mammalian aging is limited. In this study, we showed that NaDC3 overexpression accelerated cellular senescence in young human diploid cells (MRC-5 and WI-38) and primary renal tubular cells, leading to cell cycle arrest in G1 phase and increased expression of senescent biomarkers, senescence-associated β-galactosidase and p16. Intracellular levels of reactive oxygen species, 8-hydroxy-2'-deoxyguanosine, malondialdehyde, and carbonyl were significantly enhanced, and activities of respiratory complexes I and III and ATP level were significantly decreased in NaDC3-infected cells. Stressful premature senescent phenotypes induced by NaDC3 were markedly ameliorated via treatment with the antioxidants Tiron and Tempol. High expression of NaDC3 caused a prominent increase in intracellular levels of Krebs cycle intermediates and NADH. Exogenous NADH and NAD(+) may aggravate and attenuate the aging phenotypes induced by NaDC3, respectively. These results suggest that NaDC3 can induce premature cellular senescence by promoting the transport of Krebs cycle intermediates, increasing generation of NADH and reactive oxygen species and leading to oxidative damage. Our results clarify the aging signaling pathway regulated by NaDC3. © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Radiological intervention in postoperative complications following liver transplantation; Interventionelle radiologische Verfahren bei postoperativen Komplikationen nach Lebertransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Berger, H. [Inst. fuer Radiologische Diagnostik, Klinikum Grosshadern, Univ. Muenchen (Germany); Staebler, A. [Inst. fuer Radiologische Diagnostik, Klinikum Grosshadern, Univ. Muenchen (Germany); Kunzfeld, A. [Inst. fuer Radiologische Diagnostik, Klinikum Grosshadern, Univ. Muenchen (Germany); Zuelke, C. [Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Univ. Muenchen (Germany); Anthuber, M. [Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Univ. Muenchen (Germany); Kraemling, H.J. [Chirurgische Klinik und Poliklinik, Klinikum Grosshadern, Univ. Muenchen (Germany)

    1997-03-01

    Purpose: Postoperative complications contribute significantly to the morbidity and mortality of liver transplant patients. The management of these complications requires a multidisciplinary approach in which interventional radiology plays an integral role. Indications, techniques, and results of radiological interventions in the management of the liver transplant patient are presented. Material and methods: During a 10-year period, 52 out of 420 liver transplant recipients underwent radiological interventions, including angioplasty (n=20), embolization (n=2), percutaneous drainage (n=11), and biliary interventions (n=19). Results: Nine out of ten arterial stenoses located at the anastomoses (n=8), within the liver (n=1) and in the coeliac trunk (n=1) were successfully treated by balloon dilatation. Angioplasty of supra- or infrahepatic anastomotic stenoses of the IVC (n=5) provided long-term success only in combination with stent implantation. Portal vein stenoses and chronic thrombosis were treated by balloon dilatation and stent insertion via transhepatic catheterization of the portal vein. Late strictures of bile-duct anastomoses can be managed by ante- or retrograde interventions. If biliary complications are related to inflammatory or septic problems, the prognosis of graft survival is poor. Conclusion: Interventional radiological procedures are very useful in the management of vascular and biliary complications after liver transplantation. These techniques provide a cure in many situations, and thus, surgical interventions may be avoided in selected cases. (orig.) [Deutsch] Die komplexe chirurgisch-technische Operation sowie immunologische und ischaemieverursachte Probleme tragen zur relativ hohen Komplikationsrate nach Lebertransplantation bei, die grundsaetzlich organ- bzw. lebensbedrohlich fuer den Patienten sind. Interventionelle radiologische Techniken sind aufgrund ihres minimal-invasiven Charakters in der klinischen Versorgung dieser Komplikationen

  4. Abscesses after appendectomy due to intraoperative loss of fecaliths; Abszesse nach Appendektomie durch intraoperativ verlorene Appendicolithen

    Energy Technology Data Exchange (ETDEWEB)

    Hoermann, M.; Kreuzer, S. [Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria). Abt. chirurgische Faecher; Sacher, P. [UniversitaetsSpital Zuerich (Switzerland). Abt. Kinderchirurgie; Eich, G.F. [UniversitaetsSpital Zuerich (Switzerland). Inst. fuer Diagnostische Radiologie

    2001-08-01

    Objective: Fecaliths appear to predispose a patient to acute appendicitis, abscess formation, and perforation. The number of preoperative radiological evaluations is increasing, although children with suspected perforation still undergo surgery immediately. We report and discuss imaging findings and implications in children with acute appendicitis and fecalithis. Methods: Four children (3 girls, 1 boy; mean age 9 years) underwent surgery for acute appendicitis. Three children underwent sonography and plain radiography before surgery, 1 child was operated without radiological evaluation. After readmission, all 4 children underwent sonography and plain radiography before surgery. Results: In 3 patients a fecalith was diagnosed initially. After uneventful recovery all 4 patients had acute abdominal pain and readmission was necessary. In all 4 patients the escaped fecalith was demonstrated with sonography and plain radiography confirmed surgically. Conclusion: Discussion about the role of imaging in acute appendicitis has concentrated on the diagnostic yield of cross-section techniques. The importance of demonstrating a fecalith, prompting a more thorough intraoperative search has found little attention. The radiologist should also detect and localize a fecalith and should be aware of retained fecaliths as a cause of abscess formation after appendectomy. (orig.) [German] Ziel: Faekolithen praedisponieren Kinder zu akuter Appendizitis und fuehren vermehrt zu Perforation und Abszessen. Wir berichten und diskutieren die Bedeutung der Bildgebung bei Kindern mit Faekolithen und perforierter akuter Appendizitis. Methoden: 4 Kinder (drei Maedchen, ein Junge, Altersmeridian 9 Jahre) wurden wegen perforierter akuter Appendizitis operiert. Drei Kinder erhielten praeoperativ eine Ultraschalluntersuchung und ein Abdomen-Uebersichtsbild. Nach Neuaufnahme wurden nun bei allen Kindern eine Ultraschalluntersuchung und ein Abdomen-Uebersichtsbild angefertigt und neuerlich operiert

  5. Characterization of native 40 S particles from Krebs II mouse ascites tumor cells: resolution, nomenclature and molecular weights of the nonribosomal proteins

    DEFF Research Database (Denmark)

    Reichert, G; Issinger, O G

    1981-01-01

    Native 40 S particles from Krebs II mouse ascites tumor cells were isolated on a large scale. A nonribosomal protein moiety of about 30 proteins could be removed from the ribosomal particles by treatment with 250 mM KCl. These proteins were analysed by two-dimensional polyacrylamide gel...... spots were excised from two-dimensional gels and transferred directly or after electrodialysis onto the third dimension gel. The proteins fell into a molecular weight range from about 20,000 to 300,000....

  6. Environment and cancer as seen by the population of Austria; Umwelt und Krebs aus der Sicht der oesterreichischen Bevoelkerung

    Energy Technology Data Exchange (ETDEWEB)

    Wallner, P.; Haidinger, G. [Vienna Univ. (Austria). Inst. fuer Krebsforschung

    1999-04-01

    The public perception of the importance of environmental factors for carcinogenesis was investigated in a representative sample of Austrians (n=2073) who in 1995 were {>=} 15 years of age. Results show that about 60% of the respondents attribute great importance to environmental pollution as a cause for cancer development. Only smoking ranks higher. Approximately 56% of the respondents rate toxic agents in the workplace to be of great importance. In the case of pesticide residues this is true for 50% and in the case of passive smoking for 44%. High voltage power lines, `earth rays` and `water veins` are rated to be of great importance by about 25% of the respondents. The ratings of women and men do not differ except for the last two esoteric factors, with women giving more importance to them. The survey shows that the role of environmental factors in cancer development is overestimated. A better information of the public about the various cancer risks seems to be necessary. It should be based on the recommendations concerning risk communication, risk didactics and risk comparisons. (orig.) [Deutsch] Mit der vorliegenden Untersuchung sollte erhoben werden, welche Bedeutung aus Sicht der oesterreichischen Bevoelkerung Umweltfaktoren bei der Krebsentstehung zukommt. Im Rahmen der Oesterreichischen Krebsumfrage 1995 wurde eine repraesentative Stichprobe der Bevoelkerung {>=} 15 Jahre (n=2073) befragt. Rund 60% der Respondenten messen der Umweltverschmutzung grosse Bedeutung fuer die Krebsentstehung zu, sie wird damit nach dem Rauchen als wichtigster Faktor angesehen. Die Schadstoffbelastung am Arbeitsplatz hat fuer 56% der Befragten grosse Bedeutung, Pestizide in Lebensmitteln fuer 50% und Passivrauchen fuer 44%. Jeweils ungefaehr 25% der Respondenten messen Hochspannungsleitungen, Erdstrahlen und Wasseradern grosse Wichtigkeit zu. Lediglich Erdstrahlen und Wasseradern haben fuer Frauen groessere Bedeutung als fuer Maenner. Die Ergebnisse der Befragung zeigen, dass

  7. Medienkompetenz oder Medienbildung? Zur Frage nach dem Zielwert medienpädagogischer Praxis

    Directory of Open Access Journals (Sweden)

    Marius Thomann

    2015-02-01

    Full Text Available In einer Serie von vier Artikeln (Schorb 2009; Spanhel 2010; Tulodziecki 2010; Fromme u. Jörissen 2010 wurde 2009 und 2010 in der Zeitschrift merz: Medien + Erziehung die Frage nach dem Leitbegriff der Medienpädagogik diskutiert. In den vorliegenden Ausführungen wird im Bezugsrahmen dieser Debatte die Frage diskutiert, ob Medienkompetenz oder Medienbildung der Zielwert medienpädagogischer Praxis sein sollte. Dabei wird in einer argumentationstheoretischen Analyse zunächst jeweils ein deskriptives und ein normatives Argument gegen Medienkompetenz rekonstruiert und zurückgewiesen. Als Grundlage dieser Argumente zeigt sich hierbei eine begriffliche Verwechslung zwischen den theoretischen Modellen zur Medienkompetenz und der Verwendung dieses Konzepts im pädagogisch verkürzten Sinne einzelner Unterkompetenzen. Anschliessend werden drei Adäquatheitskriterien für Zielwerte medienpädagogischer Praxis vorgeschlagen, die dann als Grundlage für die Bewertung beider Alternativen im begrifflichen Bezugsrahmen der genannten Debatte dienen. Im Ergebnis empfiehlt sich Medien­kompetenz als dieser Zielwert, während das Konzept der Medienbildung begrifflicher Schärfung und einer Ausarbeitung seiner Schnittstelle zur medienpädagogischen Praxis bedarf.

  8. Modern information technology for load management and control systems; Leittechnik-Informationssysteme nach heutigem Standard

    Energy Technology Data Exchange (ETDEWEB)

    Czarnach, R. [EWAG Energie- und Wasserversorgung AG, Nuernberg (Germany); Kienzle, W. [Alcatel SEL, Stuttgart (Germany); Noack, H.E. [Siemens AG, Karlsruhe (Germany)

    1997-03-01

    The Technical Committee 5.5 - Process Data Transmission - of the Informationstechnische Gesellschaft ITG presents two of his many fields of work, i.e. applications on platforms and modern load management and control systems. These two subjects comprise not only technical aspects but also organisational, economic and sociological problems. In the opinion of the Technical Committee, these factors should get more attention in the future. The contribution intends to stimulate discussion of this point. (orig.) [Deutsch] Dem Fachausschuss 5.5 - Prozessdatenuebermittlung - der Informationstechnischen Gesellschaft ITG ist es ein Anliegen, den Begriff Prozessdatenuebermittlung sowie seine Herkunft und die Aufgabenstellung des Fachausschusses zu beschreiben. Aus seinem breiten Arbeitsbereich heraus werden die zwei Themenfelder Applikationen auf Plattformen und moderne Leittechniksysteme erlaeutert. Diese beiden Themen wurden ausgewaehlt, weil sie neben ihren technischen Aspekten auch damit zusammenhaengende organisatorische, wirtschaftliche und soziologische Fragen betrachten. Der Fachausschuss ist der Meinung, dass solche Fragestellungen oder die Suche nach Antworten, die sich mit dem bei der technischen Weiterentwicklung aendernden Wechselspiel zwischen Hersteller, Hochschulen und Anwender beleuchtet, zukuenftig einen deutlich hoeheren Stellenwert haben muss als bisher. Der Beitrag soll zur Diskussion anregen. (orig.)

  9. Imaging before and after uterine artery embolization; Bildgebende Diagnostik vor und nach Uterusmyomembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Kroencke, T.J. [Charite - Universitaetsmedizin Berlin, Radiologische Klinik, Campus Virchow-Klinikum, Berlin (Germany)

    2008-07-15

    Percutaneous catheter-based embolization treatment of symptomatic uterine fibroids has evolved into the most widely used alternative therapeutic approach to surgical treatment worldwide. Uterine artery embolization (UAE) induces infarction of leiomyomas, resulting in ischemic necrosis, hyaline degeneration, and size reduction with resolution of associated symptoms. Published experience suggests that UAE is an effective and reliable option for treating uterine fibroids with high patient satisfaction. Magnetic resonance imaging (MRI) is superior to ultrasonography for determining the site, size and number of fibroids, which is important for establishing the indication for UAE. Other potential advantages of MRI include the option of performing MR angiography (MRA) and obtaining contrast-enhanced images for monitoring the outcome of UAE and assessing possible complications after UAE. (orig.) [German] Die perkutane kathetergestuetzte Uterusmyomembolisation ist inzwischen weltweit die am meisten verbreitete Alternative zur operativen Behandlung des symptomatischen Uterus myomatosus. Der durch Embolisation der Aa. uterinae (Syn. Uterusarterienembolisation, UAE) bewirkte 'Myominfarkt' fuehrt zu ischaemischer Nekrose, hyalinem Umbau und Groessenreduktion der Myome unter Rueckbildung myomassoziierter Beschwerden. Die bisher publizierten Erfahrungen zeigen, dass es sich bei der Embolisation um eine effektive und sichere Methode mit hoher Patientinnenzufriedenheit handelt. Die Magnetresonanztomographie (MRT) ist dem Ultraschall in der fuer die Indikationsstellung wichtigen Beurteilung von Lage, Groesse und Zahl der Myomknoten ueberlegen. Weitere moegliche Vorteile ergeben sich durch den Einsatz der MR-Angiographie (MRA) sowie kontrastmittelunterstuetzter Aufnahmen zur Erfolgskontrolle und Abklaerung von Komplikationen nach Embolisation. (orig.)

  10. Palladium alpha-lipoic acid complex formulation enhances activities of Krebs cycle dehydrogenases and respiratory complexes I-IV in the heart of aged rats.

    Science.gov (United States)

    Sudheesh, N P; Ajith, T A; Janardhanan, K K; Krishnan, C V

    2009-08-01

    Age-related decline in the capacity to withstand stress, such as ischemia and reperfusion, results in congestive heart failure. Though the mechanisms underlying cardiac decay are not clear, age dependent somatic damages to mitochondrial DNA (mtDNA), loss of mitochondrial function, and a resultant increase in oxidative stress in heart muscle cells may be responsible for the increased risk for cardiovascular diseases. The effect of a safe nutritional supplement, POLY-MVA, containing the active ingredient palladium alpha-lipoic acid complex, was evaluated on the activities of the Krebs cycle enzymes such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase as well as mitochondrial complexes I, II, III, and IV in heart mitochondria of aged male albino rats of Wistar strain. Administration of 0.05 ml/kg of POLY-MVA (which is equivalent to 0.38 mg complexed alpha-lipoic acid/kg, p.o), once daily for 30 days, was significantly (pKrebs cycle dehydrogenases, and mitochondrial electron transport chain complexes. The unique electronic and redox properties of palladium alpha-lipoic acid complex appear to be a key to this physiological effectiveness. The results strongly suggest that this formulation might be effective to protect the aging associated risk of cardiovascular and neurodegenerative diseases.

  11. Investigations regarding the anthropic impact on the Krebs cycle dehydrogenases system on certain wood-species in mining areas, Suceava county

    Directory of Open Access Journals (Sweden)

    Marius Viorel Oniciuc

    2013-03-01

    Full Text Available The Krebs cycle, a second stage of cellular respiration that occurs in the mitochondrion of the leafcell and consist in a multistep processes plays a central role in catabolism of organic fuel molecules. The miningextraction technologies for both underground and surface, the preparation of copper ore and barite applied in Tarnia,respectively to the sulphur in Calimani Mountain and the excess of these elements in natural environment may causemalfunction of ecosystem. The dehydrogenases of Krebs cycle can give information on the type and the duration of theeffects of pollutants on the metabolic activity in leaves, to subsequent area pollution, therefore, the aim of the presentstudy has been to determine these effects on this enzymatic system activity. For this reason, the isocitrate dehydrogenase,the -ketoglutate dehydrogenase, the succinate ehydrogenase and the malate dehydrogenase activity was determined using the spectrophotometric method with triphenyl-tetrazolium and the analysis of experimental results shows the differences from one sample to another sample of closely related species specificity, but also the effect of environmentalfactors.

  12. Endovascular brachytherapy to prevent restenosis after angioplasty; Endovaskulaere Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Wohlgemuth, W.A.; Bohndorf, K. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie

    2003-02-01

    Endovascular radiotherapy is the first effective prophylaxis of restenosis after percutaneous transluminal angioplasty (PTA) and stenting. The FDA recently approved two devices for the delivery of intracoronary radiation following coronary artery stenting. Published multicenter, double-blind, randomized trials of intracoronary radiation therapy report good results for preventing in-stent restenosis, while the data for the peripheral circulation are still inconclusive. Beta-emitters are easier applicable and probably also safer, whereas gamma-emitters have been more extensively evaluated clinically so far. Primary indication for endovascular brachytherapy are patients at high risk for restenosis, such as previous restenoses, in-stent hyperplasia, long stented segment, long PTA lesion, narrow residual vascular lumen and diabetes. Data from coronary circulation suggest a safety margin of at least 4 to 10 mm at both ends of the angioplastic segment to avoid edge restenosis. To prevent late thrombosis of the treated coronary segment, antiplatelet therapy with clopidogrel and aspirin are recommended for at least 6 months after PTA and for 12 months after a newly implanted stent. An established medication regimen after radiotherapy of peripheral arteries is still lacking. (orig.) [German] Die endovaskulaere Radiotherapie stellt das erste erfolgreiche Therapiekonzept in der Restenoseprophylaxe nach PTA und Stentimplantation dar. Am 3.11.2000 hat die amerikanische Food and Drug Administration erstmalig zwei Brachytherapiegeraete zur Restenoseprophylaxe nach Koronararterien-Stenting zugelassen. Grosse multizentrische, kontrollierte Studien wurden fuer das koronare Stromgebiet mit positiven Ergebnissen publiziert, die Datenlage im peripheren Stromgebiet ist noch ungenuegend. Beta-Strahler bieten Vorteile in der Anwendung, moeglicherweise auch in der Sicherheit, Gamma-Strahler dagegen sind besser klinisch evaluiert. Die primaere Indikation zur endovaskulaeren Brachytherapie

  13. CARACTERIZAÇÃO DA ATIVIDADE PRÓ-OXIDANTE DE DIFERENTES AGENTES E ESTUDO DO POTENCIAL ANTIOXIDANTE DE INTERMEDIÁRIOS DO CICLO DE KREBS SOBRE ALTERAÇÕES OXIDATIVAS INDUZIDAS IN VITRO

    OpenAIRE

    Robson Luiz Puntel

    2008-01-01

    Dados prévios da literatura têm mostrado que alguns intermediários do ciclo de Krebs podem agir como antioxidantes em diversos modelos, tanto in vitro, quanto in vivo. Porém, o(s) mecanismo(s) através dos qual(is) esses intermediários exercem suas atividades antioxidantes não são completamente entendidas. Considerando a escassez de dados na literatura a respeito do efeito dos intermediários do ciclo de Krebs durante situações de estresse oxidativo, o presente trabalho teve por objetivo determ...

  14. Häufigkeit und Muster der Tumorerkennung nach Selbstuntersuchung bei Mittel- bis Hochrisiko-Melanompatienten.

    Science.gov (United States)

    Sindrilaru, Anca; Neckermann, Vera; Eigentler, Thomas; Kampilafkos, Panagiotis; Crisan, Diana; Treiber, Nicolai; Scharffetter-Kochanek, Karin; Schneider, Lars Alexander

    2017-01-01

    Die Frage, wie oft Melanompatienten mit Mittel- bis Hochrisikomelanomen den Tumor bemerken und welche Eigenerkennungsmuster existieren ist bislang nicht beantwortet. Wir haben eine retrospektive Studie an Melanompatienten durchgeführt, die sich zwischen 2004 und 2008 einer Sentinellymphknotenbiopsie unterzogen haben,. Der Fragebogen wurde von 127 der insgesamt 133 Patienten ausgefüllt. 25 % bemerkten den Tumor überhaupt nicht. Die restlichen 75 % zeigten verschiedene Eigenerkennungsmuster: 25 % holten nach 0-12 Wochen Rat ein, weitere 25 % innerhalb von 3-6 Monaten, und bei den restlichen 25 % wurde der Tumor mehr als sechs Monate lang beobachtet, bevor er entfernt wurde. Alter, Geschlecht und Lokalisation des Melanoms waren bei allen Eigenerkennungsgruppen vergleichbar. Die häufigsten Subtypen waren: SSM (59), NMM (31), ALM (9), UCM (9) und LMM (4). Seltene Subtypen (15) waren ebenfalls vorhanden. Patienten mit 3-6 Monate alten Läsionen zeigten die höchste durchschnittliche Tumordicke und die bei weitem höchste Anzahl von pT4-Tumoren. 60 % der Patienten mit NMM hatten eine Krankengeschichte von Melanome wurden in nur 50 % der Fälle selbstständig erkannt. Selbst fortgeschrittene Melanome blieben von den Patienten in 25 %, seltene Melanom-Subtypen in 50 % der Fälle unerkannt. Daher sollte der Eigenerkennungshäufigkeit, dem erhöhten Bewusstsein für seltene Melanome und der schnellen Überweisung an einen Spezialisten in zukünftigen Aufklärungskampagnen besondere Aufmerksamkeit zukommen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  15. Digital full field mammography for imaging augmented breasts; Digitale Vollfeldmammographie nach Brustaugmentation

    Energy Technology Data Exchange (ETDEWEB)

    Diekmann, S.; Diekmann, F.; Hamm, B. [Institut fuer Radiologie, Universitaetsklinikum Charite, Berlin (Germany); Hauschild, M. [Klinik fuer Frauenheilkunde und Geburtshilfe, Universitaetsklinikum Charite, Berlin (Germany)

    2002-04-01

    Purpose. The use of digital full field mammography for imaging augmented breasts.Methods. Images of a sponge, as a tissue equivalent, partly covered with one of three different implants (silicone, silicone/saline, saline) were obtained using digital and film-screen technique. The visualisation of the sponge structure covered by the implant and next to the implant was evaluated by two radiologists. Results were compared to clinical results from 35 patients with implants.Results. Two images with different parameter settings have to be obtained to visualize the covered sponge structure and the structure around the implant with film-screen technique. Digital mammography allows assessment of both areas using one image at different window settings. The assessability of covered structures depends on the type of implant. These results are in keeping with our clinical experiences.Conclusion. Digital mammography allows equal or better assessment of covered and non-covered tissue in augmented breasts without the need for additional exposures. (orig.) [German] Fragestellung. Anwendung der digitalen Vollfeldmammographie nach Mammaaugmentation mit verschiedenen Implantaten.Methodik. In einem Phantomversuch wurde ein Schwamm (Gewebeaequivalent) ueberlagert von 3 verschiedenen Implantaten (Silikon, Silikon/Kochsalz, Kochsalz) in konventioneller und digitaler Technik mit gleichen Parametern geroentgt. Es wurde die Beurteilbarkeit der Schwammstruktur neben und unter dem Implantat in beiden Techniken durch 2 Reader geprueft und den klinischen Erfahrungen bei 35 Patientinnen mit Mammaaugmentation gegenuebergestellt.Ergebnisse. Fuer die Beurteilung von verdecktem Gewebe und unverdecktem Gewebe (simuliert durch den Schwamm) muessen mit konventioneller Film-Folien-Technik zumindest 2 Aufnahmen mit verschiedenen Belichtungsparametern erstellt werden, waehrend durch eine geeignete Fensterung beides mit einer digitalen Aufnahme beurteilt werden kann. Die Beurteilbarkeit der ueberlagerten

  16. Multiparametric prostate MRI for follow-up monitoring after radiation therapy; Multiparametrische MRT der Prostata zum Therapiemonitoring nach Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Weidner, A.M.; Dinter, D.J.; Bohrer, M.; Sertdemir, M.; Hausmann, D.; Wenz, F.; Schoenberg, S.O. [Universitaetsmedizin Mannheim, Medizinische Fakultaet Mannheim der Universitaet Heidelberg, Institut fuer Klinische Radiologie und Nuklearmedizin, Mannheim (Germany)

    2012-03-15

    Radiation therapy is a therapeutic option with curative intent for patients with prostate cancer. Monitoring of prostate-specific antigen (PSA) values is the current standard of care in the follow-up. Imaging is recommended only for symptomatic patients and/or for further therapeutic options. For detection of local recurrence magnetic resonance imaging (MRI) of the prostate is acknowledged as the method of choice. Good results for primary diagnosis were found especially in combination with functional techniques, whereas in recurrent prostate cancer only few studies with heterogeneous study design are available for prostate MRI. Furthermore, changes in different MRI modalities due to radiation therapy have been insufficiently investigated to date. As the initial results were promising prostate MRI and available therapeutic options for detection of local recurrence should be considered in patients with increased PSA. (orig.) [German] Fuer Patienten mit Prostatakarzinom stellt die Radiatio eine potenziell kurative lokale Therapieoption dar. Im Rahmen der Nachsorge nach lokal kurativ intendierter Therapie wird aktuell der Verlauf des PSA-Werts (PSA prostataspezifisches Antigen) kontrolliert, der Einsatz bildgebender Verfahren wird lediglich bei symptomatischen Patienten und/oder zur Planung einer Salvagetherapie empfohlen. Die MRT der Prostata stellt derzeit die Methode der Wahl zur lokalen Rezidivdiagnostik dar. Insbesondere in Verbindung mit funktionellen Untersuchungstechniken zeigen Studien gute Ergebnisse in der Primaerdiagnostik. Zum Einsatz der MRT der Prostata in der Rezidivsituation wurden bisher nur wenige Studien mit heterogenem Studiendesign publiziert. Auch die in der MRT nach Bestrahlung sichtbaren Veraenderungen in den unterschiedlichen Modalitaeten sind noch wenig evaluiert. Da die ersten Studienergebnisse auch bei Patienten nach Radiatio viel versprechend sind, sollte bei unklarem PSA-Anstieg und vorhandener Therapieoption eine MRT der Prostata zur

  17. Kosovo - Sonderfall mit Präzedenzwirkung? Völkerrechtliche und politische Entwicklungen nach dem Gutachten des Internationalen Gerichtshofs

    OpenAIRE

    Halbach, Uwe; Richter, Solveig; Schaller, Christian

    2011-01-01

    "Im Juli 2010 bescheinigte der Internationale Gerichtshof in einem Gutachten, dass die Unabhängigkeitserklärung des Kosovo von 2008 das Völkerrecht nicht verletzt habe. Von Deutschland war der Kosovo bereits wenige Tage nach Deklaration seiner Unabhängigkeit als Staat anerkannt worden. Heute engagiert sich die Bundesrepublik dort für den Aufbau staatlicher Institutionen und bei der Förderung von Demokratie und Rechtsstaatlichkeit. Zwar haben die Bundesregierung und andere Befürworter der koso...

  18. Regierung der Teuerung nach 1848. Lebensmittelpreise und Proteste als politische und administrative Probleme in Bayern und Preußen

    OpenAIRE

    Engelns, Martina

    2016-01-01

    Die 1840er Jahre in Bayern und Preußen waren geprägt von Hungerunruhen, food riots und Bierkrawalle sowie die sich daran anschließenden Revolutionen. Was geschah, als nach einer kurzen Ruhephase die Lebensmittelpreise wieder stiegen und sich zwischen 1851 und 1856 auf ähnlich hohem Niveau wie 1846/7 hielten? Nun, dieses Mal protestierte fast niemand. Was hatte sich verändert? Ein wesentlicher Unterschied wird in diesem Buch in den Blick genommen: Ganz anders als im Vormärz reagierten die Behö...

  19. Spätnebenwirkungen nach Radiotherapie Strategien zur Vermeidung respektive Symptomlinderung bei Brust- und gynäkologischen Tumoren

    OpenAIRE

    Linsenmeier, C.

    2012-01-01

    Nach brusterhaltender Chirurgie ist die Radiotherapie indiziert, welche evidenzbasiert das Risiko für ein Lokalrezidiv senkt und das Gesamtüberleben verbessert. Auch bei gynäkologischen Tumoren ist die Radiotherapie zur besseren Tumorkontrolle angezeigt. Um Nutzen und Risiko für die Patientin abwägen zu können, sind Kenntnisse der Spätnebenwirkungen einer Strahlentherapie unerlässlich. Diese Effekte sollten auch dem gynäkologischen Grundversorger in der Krebsnachsorge bekannt sein.

  20. A review of endocrine late effects in children after brain tumor therapy; Endokrinologische Funktionsstoerungen nach Hirntumortherapie im Kindesalter

    Energy Technology Data Exchange (ETDEWEB)

    Marx, M.; Langer, T.; Beck, J.D.; Doerr, H.G. [Erlangen-Nuernberg Univ., Erlangen (Germany). Kinderklinik mit Poliklinik

    1999-07-01

    : In der Regel kommt es als erstes und am haeufigsten zu Stoerungen der Wachstumshormonsekretion. Stoerungen der spontanen Wachstumshormonsektretion wurden bereits nach konventionell fraktionierter Schaedelbestrahlung mit 18 Gy beobachtet. Mit einiger Latenz koennen auch Stoerungen der anderen hypothalamo-hypophysaeren Achsen bis hin zum Panhypopituitarismus auftreten. Die Pubertaet kann verfrueht oder verspaetet beginnen oder ganz ausbleiben. Insbesondere bei Maedchen kommt es nach Hirntumortherapie gehaeuft zur fruehen und im Ablauf beschleunigten Pubertaetsentwicklung, die durch eine akzelerierte Knochenreifung zu einer weiteren Verminderung der Endgroesse fuehrt. Hypothalamo-hypophysaer bedingte Stoerungen der Schilddruesenfunktion und der Nebennierenrindenfunktion sind seltener und werden in der Regel erst nach hypothalamo-hypophysaeren Strahlendosen von ueber 40 Gy beobachtet. Schlussfolgerung: Ueberlebende eines Hinrtumors im Kindesalter muessen als Langzeitueberlebende betrachtet werden, bei denen bereits kurz nach Ende der Tumortherapie die ersten der therapiebedingten Spaetfolgen auftreten. Um fuer den individuellen Patienten eine maximale Lebensqualitaet zu erreichen, ist eine langfristige Betreuung mit enger Kooperation der verschiedenen beteiligten Fachdisziplinen unabdingbar. (orig.)

  1. Ciclo de Krebs como fator limitante na utilização de ácidos graxos durante o exercício aeróbico

    OpenAIRE

    Curi, Rui; Lagranha, Cláudia J.; G. Jr, Jair Rodrigues; Pithon-Curi, Tania Cristina; Lancha Jr., Antonio Herbert; Pellegrinotti, Ídico L.; Procopio, Joaquim

    2003-01-01

    Os ácidos graxos (AG) representam uma fonte importante de energia durante exercícios de intensidade leve ou moderada, e principalmente naqueles de duração prolongada. A utilização dos AG pelos músculos esqueléticos depende de passos importantes como a mobilização, transporte via corrente sangüínea, passagem pelas membranas plasmática e mitocôndrial, beta-oxidação e, finalmente, a oxidação no ciclo de Krebs e atividade da cadeia respiratória. O exercício agudo e o treinamento induzem adaptaçõe...

  2. Developmental dynamics and contemporary evolutionary psychology: status quo or irreconcilable views? Reply to Bjorklund (2003), Krebs (2003), Buss and Reeve (2003), Crawford (2003), and Tooby et Al. (2003).

    Science.gov (United States)

    Lickliter, Robert; Honeycutt, Hunter

    2003-11-01

    The authors address commentaries by D. F. Bjorklund (2003); D. M. Buss and H. K. Reeve (2003); C. B. Crawford (2003); D. L. Krebs (2003); and J. Tooby, L. Cosmides, and H. C. Barrett (2003) on their analysis of the underlying assumptions of contemporary evolutionary psychology (R. Lickliter & H. Honeycutt, 2003). The authors argue that evolutionary psychology currently offers no coherent framework for how to integrate genetic, environmental, and experiential factors into a theory of behavioral or cognitive phenotypes. The authors propose that this absence is due to a lack of developmental analysis in the major works of evolutionary psychology, resulting in an almost exclusive focus on adaptationist accounts of evolution by natural selection rather than a more broad-based focus on the process and products of evolution by epigenetic developmental dynamics.

  3. Docosohaexanoic acid-supplemented PACA44 cell lines and over-activation of Krebs cycle: an integrated proteomic, metabolomic and interactomic overview.

    Science.gov (United States)

    D'Alessandro, Angelo; D'Amici, Gian Maria; Timperio, Anna Maria; Merendino, Nicolò; Zolla, Lello

    2011-09-06

    Recent investigations have pointed out the ability of fatty acids, in particular of docosohaexanoic acid (DHA), to induce growth inhibition and apoptosis in the human PaCa-44 pancreatic cancer cell line through a series of mechanisms which has been hypothesized to mimic apoptosis. While preliminary evidences indicated the involvement of lipid-targeting oxidative stress in DHA-induced apoptotic processes, mainly through the alteration of the glutathione (GSH) homeostasis and oxidized-glutathione (GSSG) turn-over through their extra-cellular extrusion, no further molecular data have been hitherto accumulated. To this end, we hereby propose simultaneous protein-targeting and metabolite-oriented analyses, which have been integrated through the auxilium of in silico elaboration of those protein-protein interaction pathways and enrichment of biological/molecular functions. To determine the most suitable time window for the early onset of the DHA-triggered apoptosis phenomena we performed flow cytometry-based apoptotic assessment at 24, 48 and 72 h. Results indicated that the focus of apoptosis onset ranged from 48 to 72 h. From these analyses it emerges that the metabolism of control human PaCa-44 pancreatic cancer cell line mainly leans on glycolytic pathways, while it is promptly switched to Kreb's cycle activation (overexpression of Kreb's cycle enzymes in DHA-treated cells against controls) and modulation of the GSH homeostasis through an increased production of GSSG-reducing NADPH coenzyme via the shift of the glycolytic energy flux towards the pentose phosphate pathway. Interestingly, it also emerges a role for structural protein alteration in DHA-treated cells, which might be linked to cytoskeletal alterations occurring during apoptosis. Copyright © 2011 Elsevier B.V. All rights reserved.

  4. HRCT and bronchial asthma: visualization of the pathophysiologic changes of the pulmonary parenchyma after inhalation provocation; HRCT und Asthma bronchiale: Visualisierung pathophysiologischer Veraenderungen des Lungenparenchyms nach inhalativer Provokation

    Energy Technology Data Exchange (ETDEWEB)

    Schueller, G.; Neumann, K.; Helbich, T.; Herold, C.J. [Univ. Klinik fuer Radiodiagnostik, Abt. fuer konservative Faecher, Vienna (Austria); Riemer, H. [Univ. Klinik fuer Innere Medizin IV, Abt. fuer Pulmologie, Vienna (Austria); Backfrieder, W. [Allgemeines Krankenhaus, Vienna (Austria). Inst. fuer Biomedizinische Technik und Physik; Sertl, K. [Krankenhaus der Stadt Wien-Floridsdorf (Austria). Abt. fuer Innere Medizin; Pittner, B. [Vienna Univ. (Austria). Inst. fuer Medizinische Statistik

    2004-03-01

    alterations of the lung parenchyma subsequent to inhalation provocation. In healthy individuals, these parenchymal alterations were not documented by pulmonary function tests. (orig.) [German] Ziel: Bei Patienten mit leichtem intermittierenden Asthma bronchiale, aber mit Hyperreaktivitaet auch im freien Intervall, und bei gesunden Probanden sollen mithilfe der hoch aufloesenden Computertomographie (HRCT) roentgenmorphologische Veraenderungen des Lungenparenchyms vor sowie nach inhalativer Histaminprovokation und darauf folgender Lyse durch Salbutamol charakterisiert und mit Ergebnissen von Lungenfunktionstests (FEV{sub 1}, Blutgase) verglichen werden. Methoden: Fuenfzehn Asthmatiker mit bronchialer Hyperreaktivitaet mit FEV{sub 1}-Abfall>20% und PaO{sub 2}-Abfall>10 mmHg nach Provokation (PC20%+), zwoelf Asthmatiker mit FEV{sub 1}-Abfall<20% und PaO{sub 2}-Abfall>10 mmHg nach Provokation (PC20%-) sowie acht Probanden ohne bronchiale Hyperreaktivitaet wurden mit der spirometrisch kontrollierten HRCT bei hohen Fuellungsvolumina vor und nach inhalativer Bronchoprovokation sowie nach Broncholyse untersucht. Es wurden die gesamte und periphere Lungendichte sowie der strukturelle Anteil solider pulmonaler Strukturen bestimmt. Ergebnisse: In allen Gruppen fand sich nach Provokation eine signifikante Abnahme (p<0,0005), nach Broncholyse eine signifikante Zunahme (p<0,0002) der Lungendichte. Die Aenderungen solider Lungenanteile waren nach Provokation und Lyse nicht signifikant unterschiedlich (p>0,05). Bei den hyperreaktiven Patienten fanden sich signifikante PaO{sub 2}-Abnahmen nach Provokation sowie signifikante PaO{sub 2}-Steigerungen nach Lyse (p<0,05). In der Gruppe PC20%+ wurde nach Provokatio ein mittlerer FEV{sub 1}-Abfall von 27,8% beobachtet, in den anderen Gruppen war dieser <20%. Es wurden keine signifikanten Korrelationen zwischen radiologischen und funktionellen Lungentestergebnissen asthmatischer Patienten und Probanden beobachtet. Die bei gesunden Probanden mit der

  5. Effect of ageing and ischemia on enzymatic activities linked to Krebs' cycle, electron transfer chain, glutamate and aminoacids metabolism of free and intrasynaptic mitochondria of cerebral cortex.

    Science.gov (United States)

    Villa, Roberto Federico; Gorini, Antonella; Hoyer, Siegfried

    2009-12-01

    The effect of ageing and the relationships between the catalytic properties of enzymes linked to Krebs' cycle, electron transfer chain, glutamate and aminoacid metabolism of cerebral cortex, a functional area very sensitive to both age and ischemia, were studied on mitochondria of adult and aged rats, after complete ischemia of 15 minutes duration. The maximum rate (Vmax) of the following enzyme activities: citrate synthase, malate dehydrogenase, succinate dehydrogenase for Krebs' cycle; NADH-cytochrome c reductase as total (integrated activity of Complex I-III), rotenone sensitive (Complex I) and cytochrome oxidase (Complex IV) for electron transfer chain; glutamate dehydrogenase, glutamate-oxaloacetate-and glutamate-pyruvate transaminases for glutamate metabolism were assayed in non-synaptic, perikaryal mitochondria and in two populations of intra-synaptic mitochondria, i.e., the light and heavy mitochondrial fraction. The results indicate that in normal, steady-state cerebral cortex, the value of the same enzyme activity markedly differs according (a) to the different populations of mitochondria, i.e., non-synaptic or intra-synaptic light and heavy, (b) and respect to ageing. After 15 min of complete ischemia, the enzyme activities of mitochondria located near the nucleus (perikaryal mitochondria) and in synaptic structures (intra-synaptic mitochondria) of the cerebral tissue were substantially modified by ischemia. Non-synaptic mitochondria seem to be more affected by ischemia in adult and particularly in aged animals than the intra-synaptic light and heavy mitochondria. The observed modifications in enzyme activities reflect the metabolic state of the tissue at each specific experimental condition, as shown by comparative evaluation with respect to the content of energy-linked metabolites and substrates. The derangements in enzyme activities due to ischemia is greater in aged than in adult animals and especially the non-synaptic and the intra-synaptic light

  6. Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.

    Science.gov (United States)

    Sookoian, Silvia; Castaño, Gustavo O; Scian, Romina; Fernández Gianotti, Tomas; Dopazo, Hernán; Rohr, Cristian; Gaj, Graciela; San Martino, Julio; Sevic, Ina; Flichman, Diego; Pirola, Carlos J

    2016-02-01

    Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental characteristics of this relation are currently unknown. We aimed to explore the role of liver aminotransferases in nonalcoholic fatty liver disease (NAFLD) and MetS. Liver gene- and protein-expression changes of aminotransferases, including their corresponding isoforms, were evaluated in a case-control study of patients with NAFLD (n = 42), which was proven through a biopsy (control subjects: n = 10). We also carried out a serum targeted metabolite profiling to the glycolysis, gluconeogenesis, and Krebs cycle (n = 48) and an exploration by the next-generation sequencing of aminotransferase genes (n = 96). An in vitro study to provide a biological explanation of changes in the transcriptional level and enzymatic activity of aminotransferases was included. Fatty liver was associated with a deregulated liver expression of aminotransferases, which was unrelated to the disease severity. Metabolite profiling showed that serum aminotransferase concentrations are a signature of liver metabolic perturbations, particularly at the amino acid metabolism and Krebs cycle level. A significant and positive association between systolic hypertension and liver expression levels of glutamic-oxaloacetic transaminase 2 (GOT2) messenger RNA (Spearman R = 0.42, P = 0.03) was observed. The rs6993 located in the 3' untranslated region of the GOT2 locus was significantly associated with features of the MetS, including arterial hypertension [P = 0.028; OR: 2.285 (95% CI: 1.024, 5.09); adjusted by NAFLD severity] and plasma lipid concentrations. In the context of an abnormal hepatic triglyceride accumulation, circulating aminotransferases rise as a consequence of the need for increased reactions of transamination to cope with the liver metabolic derangement that is associated with greater gluconeogenesis and

  7. Increasing oil prices promote sales. Tuebingen-based market leader introduced pellet heating systems in Germany; Steigender Oelpreis als Konjunkturprogramm. Tuebinger Marktfuehrer brachte Pelletheizung nach Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, B.

    2001-09-01

    It was a Tuebingen organisation that first introduced wood pellet heating systems in Germany. Sales were improved by the increasing oil price. [German] Ein Tuebinger Unternehmen brachte die Holzpellets-Heizung nach Deutschland. Ein steigender Oelpreis diente dabei als 'Konjunkturprogramm'. (orig.)

  8. Der Konflikt zwischen einzelstaatlichem Verbraucherrecht und freiem Warenverkehr nach Art. 30 EWGV im Vergleich mit US-amerikanischen Erfahrungen und Lösungen

    OpenAIRE

    Merke, Gerd

    1987-01-01

    Der Konflikt zwischen einzelstaatlichem Verbraucherrecht und freiem Warenverkehr nach Art. 30 EWGV im Vergleich mit US-amerikanischen Erfahrungen und Lösungen. - Rheinfelden : Schäuble, 1987. - XIV, 211 S. - Zugl.: Augsburg, Univ., Diss. - (Recht-Wirtschaft-Gesellschaft : Recht ; 5)

  9. Die Beziehungen zwischen E. F. v. Schlotheim und D. L. G. Karsten (nach den Briefen von Karsten an Schlotheim

    Directory of Open Access Journals (Sweden)

    G. Hoppe

    2001-01-01

    Full Text Available Ein anonymes Angebot zum Mineraltausch von 1790 und anschließende, bisher unbekannte Briefe leiteten die Beziehungen von D. L. G. Karsten zu E. F. v. Schlotheim ein. Der später berühmte Paläontologe Schlotheim zeigte sich noch ganz als mineralogischer Sammler. Nach dem Studium Schlotheims an der Bergakademie in Freiberg setzten sich die Kontakte fort. Sie lassen Karstens lebhaftes Interesse an Schlotheims beginnenden paläontologischen Arbeiten erkennen. So far unknown letters from D. L. G. Karsten to E. F. v. Schlotheim and an offer to change minerals from the year 1790 stated the connection between both men. The later famous paleontologist Schlotheim was a mineralogical collector at that time. After studying in Freiberg, Schlotheim developed paleontological interests. In this Karsten confirmed him. doi:10.1002/mmng.20010040103

  10. Aktuelle Technik der Bruststraffung beim Mann nach Gewichtsverlust [Modern technique in male breast contouring after weight loss

    Directory of Open Access Journals (Sweden)

    Stoff, Alexander

    2013-08-01

    Full Text Available [english] The morbid adiposity and its medical consequences demonstrates a growing problem of our current prosperous society. Due to a significant improvement of bariatric techniques and a reduplication of adipose patients during the 20 century, the number of patients, who present to plastic surgeons with a new degree of suffering, has been growing steadily. Initially, the female patients were in the majority, which has been more balanced nowadays.The male breast is a body region that primarily symbolizes masculinity and strenght. In male patients after massive weight loss, this body region remains as an extremly deflated breast envelope without any sign of possible retraction. The plastic surgeon may choose from different single or combinated ltechniques, which are indicated depending on the local and adjacent tissue characteristics.We are presenting our modified technique of male breast reshaping, referring to the technique of Aly, except for a NAC transposition on a central pedicle. The central pedicle is hereby preserved from resection after tremendous liposuction. This central pedicle technique allows a safe and uncomplicated NAC transposition with significant advantages compared to free NAC-Transposition techniques in terms of aesthetical and functional outcome. [german] Die morbide Adipositas mit ihren Langzeitfolgen ist ein zunehmendes Problem unserer heutigen Wohlstandsgesellschaft. Mit einer Verdoppelung der betroffenen Patienten im Laufe des 20. Jahrhunderts ist gleichzeitig durch rasante Verbesserung der bariatrischen Eingriffe auch die Zahl der Patienten signifikant und stetig gestiegen, die sich nach massiver Gewichtsreduktion nun mit neuem Leidensdruck beim Plastischen Chirurgen vorstellen. Hierbei ist die anfängliche Überzahl der weiblichen Patienten in ein ausgewogenes Verhältnis der betroffenen Geschlechter übergegangen. Die männliche Brust, eine Körperregion, die in erster Linie Männlichkeit und Stärke symbolisiert und

  11. Active cheerleading with radial nerve palsy following supracondylar humerus fracture [Cheerleading mit Radialisparese nach suprakondylärer Humerusfraktur

    Directory of Open Access Journals (Sweden)

    Herold, Christian

    2013-10-01

    Full Text Available [english] Cheerleading is associated with substantial morbidity. As such, cheerleading fall-related injuries may cause serious to fatal outcomes especially falls from attempted pyramids. We report on a female adolescent cheerleader age 14 suffering a supracondylar humerus fracture related to a fall from a pyramid. Unfortunately, lateral pinning led to complete iatrogenic radial nerve palsy. However, given an intriguing compensatory athletic function of the wrist she was able to perform cheerleading artistic figures such as flic-flac within four months after the injury with a radial nerve palsy, which is highlighted in an attached video. 18 months after the radial palsy she was admitted to our hospital and underwent neuroma resection of the initially transsected radial nerve at the elbow and sural nerve grafting for radial nerve palsy.[german] Cheerleading kann zu verschiedensten Unfällen führen. Insbesondere bei dem Versuch Pyramiden zu bilden sind bereits Todesfälle aufgetreten. Wir berichten von einer 14-jährigen Cheerleaderin welche bei dem Versuch eine Pyramide zu bilden stürzte und sich eine suprakondyläre Humerusfraktur zuzog. Bei der osteosynthetischen Versorgung kam es leider zu einer kompletten Durchtrennung des N. radialis. Dennoch konnte sie bei der gegebenen erstaunlichen Kompensation ihrer Handgelenksgeweglichkeit weiterhin schwierige Cheerleading Übungen wie Flick-Flack durchführen, was im beigefügten Video verdeutlicht wird. 18 Monate nach Eintreten der Radialisparese wurde sie in unserer Klinik vorstellig und es wurde nach einer Neuromresektion eine Suralis Interposition zur Nervenrekonstruktion durchgeführt.

  12. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

    Directory of Open Access Journals (Sweden)

    Elena Favaro

    2010-04-01

    Full Text Available Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1 and a microRNA, hsa-miR-210 (miR-210 which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism. Down regulation of ISCU was the major cause of induction of reactive oxygen species (ROS in hypoxia. ISCU suppression reduced mitochondrial complex 1 activity and aconitase activity, caused a shift to glycolysis in normoxia and enhanced cell survival. Cancers with low ISCU had a worse prognosis.Induction of these major hallmarks of cancer show that a single microRNA, miR-210, mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation.

  13. Succinate dehydrogenase (SDHx) mutations in pituitary tumors: could this be a new role for mitochondrial complex II and/or Krebs cycle defects?

    Science.gov (United States)

    Xekouki, Paraskevi; Stratakis, Constantine A

    2012-12-01

    Succinate dehydrogenase (SDH) or mitochondrial complex II is a multimeric enzyme that is bound to the inner membrane of mitochondria and has a dual role as it serves both as a critical step of the tricarboxylic acid or Krebs cycle and as a member of the respiratory chain that transfers electrons directly to the ubiquinone pool. Mutations in SDH subunits have been implicated in the formation of familial paragangliomas (PGLs) and/or pheochromocytomas (PHEOs) and in Carney-Stratakis syndrome. More recently, SDH defects were associated with predisposition to a Cowden disease phenotype, renal, and thyroid cancer. We recently described a kindred with the coexistence of familial PGLs and an aggressive GH-secreting pituitary adenoma, harboring an SDHD mutation. The pituitary tumor showed loss of heterozygosity at the SDHD locus, indicating the possibility that SDHD's loss was causatively linked to the development of the neoplasm. In total, 29 cases of pituitary adenomas presenting in association with PHEOs and/or extra-adrenal PGLs have been reported in the literature since 1952. Although a number of other genetic defects are possible in these cases, we speculate that the association of PHEOs and/or PGLs with pituitary tumors is a new syndromic association and a novel phenotype for SDH defects.

  14. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

    Science.gov (United States)

    Favaro, Elena; Ramachandran, Anassuya; McCormick, Robert; Gee, Harriet; Blancher, Christine; Crosby, Meredith; Devlin, Cecilia; Blick, Christopher; Buffa, Francesca; Li, Ji-Liang; Vojnovic, Borivoj; Pires das Neves, Ricardo; Glazer, Peter; Iborra, Francisco; Ivan, Mircea; Ragoussis, Jiannis; Harris, Adrian L

    2010-04-26

    Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis. In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism. Down regulation of ISCU was the major cause of induction of reactive oxygen species (ROS) in hypoxia. ISCU suppression reduced mitochondrial complex 1 activity and aconitase activity, caused a shift to glycolysis in normoxia and enhanced cell survival. Cancers with low ISCU had a worse prognosis. Induction of these major hallmarks of cancer show that a single microRNA, miR-210, mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation.

  15. STUDIES ON THE DYNAMICS OF DEHYDROGENASES KREBS CYCLE ACTIVITY AT MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS GROWN ON MEDIA WITH DIFFERENT CARBOHYDRATES

    Directory of Open Access Journals (Sweden)

    Elena Ciornea

    2011-11-01

    Full Text Available As ubiquitous organisms, fungi grow on a large number of organic substrate, alive or dead, confronting therefore with a wide variety of carbohydrates and various physical factors, and their versatility to adapt and be able to use a large number of these compounds could provide them the chance to survive. Given that, these fungi have a rich enzyme equipment that allows them to operate on different metabolic pathways, this study aims to monitor the dynamics activity of some Krebs cycle dehydrogenases in Monilinia laxa (Aderh & Ruhl. Honey species parasitic on various species of plum trees. To this end, the fungus was cultivated in vitro on media enriched with different carbohydrates and the isocitrate dehydrogenase, �-cetoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activity in the fungus mycelium was followed, at 7, respectively, 14 days after the inoculation of the culture medium and determined using the spectrophotometric Sîsoev and Krasna method (Cojocaru, D.C., 2009. Data revealed obvious differences depending on the type of carbohydrate introduced into the medium and the age of the culture mycelia.

  16. Global transcription analysis of Krebs tricarboxylic acid cycle mutants reveals an alternating pattern of gene expression and effects on hypoxic and oxidative genes.

    Science.gov (United States)

    McCammon, Mark T; Epstein, Charles B; Przybyla-Zawislak, Beata; McAlister-Henn, Lee; Butow, Ronald A

    2003-03-01

    To understand the many roles of the Krebs tricarboxylic acid (TCA) cycle in cell function, we used DNA microarrays to examine gene expression in response to TCA cycle dysfunction. mRNA was analyzed from yeast strains harboring defects in each of 15 genes that encode subunits of the eight TCA cycle enzymes. The expression of >400 genes changed at least threefold in response to TCA cycle dysfunction. Many genes displayed a common response to TCA cycle dysfunction indicative of a shift away from oxidative metabolism. Another set of genes displayed a pairwise, alternating pattern of expression in response to contiguous TCA cycle enzyme defects: expression was elevated in aconitase and isocitrate dehydrogenase mutants, diminished in alpha-ketoglutarate dehydrogenase and succinyl-CoA ligase mutants, elevated again in succinate dehydrogenase and fumarase mutants, and diminished again in malate dehydrogenase and citrate synthase mutants. This pattern correlated with previously defined TCA cycle growth-enhancing mutations and suggested a novel metabolic signaling pathway monitoring TCA cycle function. Expression of hypoxic/anaerobic genes was elevated in alpha-ketoglutarate dehydrogenase mutants, whereas expression of oxidative genes was diminished, consistent with a heme signaling defect caused by inadequate levels of the heme precursor, succinyl-CoA. These studies have revealed extensive responses to changes in TCA cycle function and have uncovered new and unexpected metabolic networks that are wired into the TCA cycle.

  17. STUDIES CONCERNING THE INFLUENCE OF SOME AMINO ACIDS ON THE DYNAMICS OF KREBS CYCLE DEHYDROGENASES ACTIVITY AT MONILINIA LAXA (ADERH.& RUHL. HONEY PARASITE ON PLUM TREES

    Directory of Open Access Journals (Sweden)

    Elena Tutu

    2011-11-01

    Full Text Available As ubiquitous organisms, fungi grow on a large number of organic substrate, alive or dead, confronting therefore with a wide variety of carbohydrates and various physical factors, and their versatility to adapt and be able to use a large number of these compounds could provide them the chance to survive. Given that, these fungi have a rich enzyme equipment that allows them to operate on different metabolic pathways, this study aims to monitor the dynamics activity of some Krebs cycle dehydrogenases in Monilinia laxa (Aderh & Ruhl. Honey species parasitic on various species of plum trees. To this end, the fungus was cultivated in vitro on media enriched with different carbohydrates and the isocitrate dehydrogenase, �-cetoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activity in the fungus mycelium was followed, at 7, respectively, 14 days after the inoculation of the culture medium and determined using the spectrophotometric Sîsoev and Krasna method (Cojocaru, D.C., 2009. Data revealed obvious differences depending on the type of carbohydrate introduced into the medium and the age of the culture mycelia.

  18. STUDIES ON THE DYNAMICS OF DEHYDROGENASES KREBS CYCLE ACTIVITY AT MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS GROWN ON MEDIA WITH DIFFERENT CARBOHYDRATES

    Directory of Open Access Journals (Sweden)

    Elena Ciornea

    2010-09-01

    Full Text Available As ubiquitous organisms, fungi grow on a large number of organic substrate, alive or dead, confronting therefore with a wide variety of carbohydrates and various physical factors, and their versatility to adapt and be able to use a large number of these compounds could provide them the chance to survive. Given that, these fungi have a rich enzyme equipment that allows them to operate on different metabolic pathways, this study aims to monitor the dynamics activity of some Krebs cycle dehydrogenases in Monilinia laxa (Aderh & Ruhl. Honey species parasitic on various species of plum trees. To this end, the fungus was cultivated in vitro on media enriched with different carbohydrates and the isocitrate dehydrogenase, �-cetoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activity in the fungus mycelium was followed, at 7, respectively, 14 days after the inoculation of the culture medium and determined using the spectrophotometric Sîsoev and Krasna method (Cojocaru, D.C., 2009. Data revealed obvious differences depending on the type of carbohydrate introduced into the medium and the age of the culture mycelia.

  19. Lassen Veränderungen des Prostata-spezifischen Antigen- (PSA- Spiegels nach Prostatastanzbiopsie Rückschlüsse auf das pathologische Ergebnis zu?

    Directory of Open Access Journals (Sweden)

    Volkmer BG

    2004-01-01

    Full Text Available Einleitung: Die diagnostische Biopsie der Prostata führt bekanntermaßen zum Anstieg des Serum-PSA-Spiegels. Diese prospektive Untersuchung sollte die Frage klären, ob die Änderungen des Serum-PSA-Spiegels nach Stanzbiopsie Rückschlüsse auf das histologische Ergebnis zulassen und so als Entscheidungshilfe bei der Frage der Rebiopsie dienen können. Patienten und Methoden: Insgesamt 79 konsekutive Patienten mit klinischem Verdacht auf das Vorliegen eines Prostatakarzinoms (PCA und einem Gesamt-PSA 50 ng/ml wurden in die Studie eingeschlossen. Ausschlußkriterien waren klinische Hinweise für eine Prostatitis und Prostatabiopsie innerhalb der letzten 3 Monate. Die Serum-PSA-Werte wurden mit einem ultrasensitiven Enzymimmunoassay bestimmt. Die Bestimmung des Gesamt-PSA und des freien PSA im Serum erfolgte unmittelbar vor und 60 Minuten nach der Biopsie. Die Spiegel des Gesamt-PSA und freien PSA, sowie die f/t-PSA-Ratio vor und nach Biopsie wurden in Korrelation zum histologischen Ergebnis gesetzt. Ergebnisse: 86 Biopsieserien wurden bei 79 Patienten durchgeführt. 38 Biopsieserien diagnostizierten ein PCA, 48 eine benigne Prostatahyperplasie (BPH. Die abschließende Histologie nach wiederholter Biopsie war PCA und BPH in je 43 Fällen. Insgesamt fand sich ein Anstieg des durchschnittlichen Gesamt-PSA von 18,39 ng/ml auf 107,8 ng/ml, des durchschnittlichen freien PSA von 3,43 ng/ml auf 33,7 ng/ml und der durchschnittlichen f/t PSA-Ratio von 18,1 % auf 52,0 %. Es fand sich keine Korrelation zwischen dem Anstieg dieser Parameter und der Anzahl der Biopsiezylinder (4–51. Bezüglich des histologischen Befundes ergaben sich statistisch signifikante Unterschiede für das Gesamt-PSA vor und die f/t PSA-Ratio vor und nach Stanzbiopsie. Schlußfolgerung: Die Analyse der PSA-Parameter nach Stanzbiopsie bietet keine zusätzliche Information über die konventionellen PSA-Parameter vor der Biopsie hinaus. Sie korrelieren vor allem nicht mit falsch

  20. Predictive parameters of infectiologic complications in patients after TIPSS; Praediktive Parameter infektiologischer Komplikationen bei Patienten nach TIPSS-Anlage

    Energy Technology Data Exchange (ETDEWEB)

    Cohnen, M.; Saleh, A.; Moedder, U. [Institut fuer Diagnostische Radiologie, Universitaetsklinikum Duesseldorf (Germany); Luethen, R.; Bode, J.; Haeussinger, D. [Klinik fuer Gastroenterologie, Hepatologie und Infektiologie, Universitaetsklinikum Duesseldorf (Germany); Daeubener, W. [Institut fuer Mikrobiologie und Virologie, Universitaetsklinikum Duesseldorf (Germany)

    2003-02-01

    Aim To define predictive parameters of a complicated clinical course after the TIPSS procedure. Blood cultures were drawn prospectively in 41 patients from a central line and from the portal venous blood before stent placement as well as from the central line 20 min after intervention. C-reactive proteine (CRP) (mg/dl) and white blood cell count (WBC,/{mu}l) on the day of TIPSS-procedure (d0), the first (d1) and seven (d7) days after TIPSS were compared in patients with a complicated clinical course (spontaneous bacterial peritonitis, pneumonia, sepsis; group I) to patients without clinical complications (group II) Group I showed a significant increase in CRP (d0: 1.8{+-}1.0; d1: 3.2{+-}1.5; d7: 4.3{+-}3.2), and white blood cell count (d0: 7700{+-}2600; d1: 10800{+-}2800; d7: 7500{+-}1800) on the first day after TIPSS-procedure in comparison to group II (CRP: d0: 1.6{+-}0.6; d1: 1.8{+-}1.0; d7: 1.9{+-}0.6. WBC: d0: 6900{+-}1500; d1: 8000{+-}1600; d7: 7600{+-}1400).Microbiological analysis showed in 12% skin or oral flora in the last sample. The course of CRP and WBC-count during the first week after TIPSS procedure may indicate patients with a potential risk of a complicated clinical course. (orig.) [German] Fragestellung Definition praediktiver Parameter infektiologischer Komplikationen bei Patienten nach TIPSS-Anlage.Methodik Bei 41 Patienten wurden Blutproben prospektiv vor intrahepatischer Stentanlage zentralvenoes und portalvenoes sowie 20 min postinterventionell erneut zentralvenoes entnommen und mikrobiologisch analysiert. C-reaktives Protein (CRP) (mg/dl) und Leukozytenzahl (/{mu}l) wurden am Interventionstag (d0), am 1. (d1) sowie 7 Tage (d7) postinterventionell bestimmt. Patienten mit kompliziertem Verlauf (spontane bakterielle Peritonitis,Pneumonie, Sepsis; Gruppe 1) wurden von Patienten ohne klinische Komplikationen (Gruppe 2) unterschieden.Ergebnisse Gruppe 1 wies einen signifikanten Anstieg des CRP (d0: 1,8{+-}1,0; d1: 3,2{+-}1,5; d7: 4,3{+-}3,2) und

  1. Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage.

    Science.gov (United States)

    Tchetina, Elena V; Markova, Galina A; Poole, A Robin; Zukor, David J; Antoniou, John; Makarov, Sergey A; Kuzin, Aleksandr N

    2016-01-01

    This study reports the effects of the iron chelator deferoxamine (DFO) on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA) articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1-50 μM). Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK) concentrations were measured using ELISAs. Gene expression studies employed real-time PCR and included AMPK analyses in PBMCs. In OA explants collagen cleavage was frequently downregulated by 10-50 μM DFO. PCR analysis of 7 OA patient cartilages revealed that 10 μM DFO suppressed expression of MMP-1, MMP-13, IL-1β, and TNFα and a marker of chondrocyte hypertrophy, COL10A1. No changes were observed in the expression of glycolysis-related genes. In contrast, expressions of genes associated with the mitochondrial Krebs cycle (TCA), AMPK, HIF1α, and COL2A1 were upregulated. AMPK gene expression was reduced in OA cartilage and increased in PBMCs from the same patients compared to healthy controls. Our studies demonstrate that DFO is capable of suppressing excessive collagenase-mediated type II collagen cleavage in OA cartilage and reversing phenotypic changes. The concomitant upregulation of proanabolic TCA-related gene expressions points to a potential for availability of energy generating substrates required for matrix repair by end-stage OA chondrocytes. This might normally be prevented by high whole-body energy requirements indicated by elevated AMPK expression in PBMCs of OA patients.

  2. Aconitase post-translational modification as a key in linkage between Krebs cycle, iron homeostasis, redox signaling, and metabolism of reactive oxygen species.

    Science.gov (United States)

    Lushchak, Oleh V; Piroddi, Marta; Galli, Francesco; Lushchak, Volodymyr I

    2014-01-01

    Aconitase, an enzyme possessing an iron-sulfur cluster that is sensitive to oxidation, is involved in the regulation of cellular metabolism. There are two isoenzymes of aconitase (Aco)--mitochondrial (mAco) and cytosolic (cAco) ones. The primary role of mAdco is believed to be to control cellular ATP production via regulation of intermediate flux in the Krebs cycle. The cytosolic Aco in its reduced form operates as an enzyme, whereas in the oxidized form it is involved in the control of iron homeostasis as iron regulatory protein 1 (IRP1). Reactive oxygen species (ROS) play a central role in regulation of Aco functions. Catalytic Aco activity is regulated by reversible oxidation of [4Fe-4S]²⁺ cluster and cysteine residues, so redox-dependent posttranslational modifications (PTMs) have gained increasing consideration as regards possible regulatory effects. These include modifications of cysteine residues by oxidation, nitrosylation and thiolation, as well as Tyr nitration and oxidation of Lys residues to carbonyls. Redox-independent PTMs such as phosphorylation and transamination also have been described. In the presence of a sustained ROS flux, redox-dependent PTMs may lead to enzyme damage and cell stress by impaired energy and iron metabolism. Aconitase has been identified as a protein that undergoes oxidative modification and inactivation in aging and certain oxidative stress-related disorders. Here we describe possible mechanisms of involvement of the two aconitase isoforms, cAco and mAco, in the control of cell metabolism and iron homeostasis, balancing the regulatory, and damaging effects of ROS.

  3. CypD(-/-) hearts have altered levels of proteins involved in Krebs cycle, branch chain amino acid degradation and pyruvate metabolism.

    Science.gov (United States)

    Menazza, Sara; Wong, Renee; Nguyen, Tiffany; Wang, Guanghui; Gucek, Marjan; Murphy, Elizabeth

    2013-03-01

    Cyclophilin D (CypD) is a mitochondrial chaperone that has been shown to regulate the mitochondrial permeability transition pore (MPTP). MPTP opening is a major determinant of mitochondrial dysfunction and cardiomyocyte death during ischemia/reperfusion (I/R) injury. Mice lacking CypD have been widely used to study regulation of the MPTP, and it has been shown recently that genetic depletion of CypD correlates with elevated levels of mitochondrial Ca(2+). The present study aimed to characterize the metabolic changes in CypD(-/-) hearts. Initially, we used a proteomics approach to examine protein changes in CypD(-/-) mice. Using pathway analysis, we found that CypD(-/-) hearts have alterations in branched chain amino acid metabolism, pyruvate metabolism and the Krebs cycle. We tested whether these metabolic changes were due to inhibition of electron transfer from these metabolic pathways into the electron transport chain. As we found decreased levels of succinate dehydrogenase and electron transfer flavoprotein in the proteomics analysis, we examined whether activities of these enzymes might be altered. However, we found no alterations in their activities. The proteomics study also showed a 23% decrease in carnitine-palmitoyltransferase 1 (CPT1), which prompted us to perform a metabolomics analysis. Consistent with the decrease in CPT1, we found a significant decrease in C4/Ci4, C5-OH/C3-DC, C12:1, C14:1, C16:1, and C20:3 acyl carnitines in hearts from CypD(-/-) mice. In summary, CypD(-/-) hearts exhibit changes in many metabolic pathways and caution should be used when interpreting results from these mice as due solely to inhibition of the MPTP. Published by Elsevier Ltd.

  4. Influence of sodium chloride on the regulation of Krebs cycle intermediates and enzymes of respiratory chain in mungbean (Vigna radiata L. Wilczek) seedlings.

    Science.gov (United States)

    Saha, Papiya; Kunda, Pranamita; Biswas, Asok K

    2012-11-01

    The effect of common salt (NaCl) on ion contents, Krebs cycle intermediates and its regulatory enzymes was investigated in growing mungbean (Vigna radiata L. Wilczek, B 105) seedlings. Sodium and chloride ion contents increased in both root and shoot whereas potassium ion content decreased in shoot of test seedlings with increasing concentrations of NaCl. Organic acids like pyruvate and citrate levels increased whereas malate level decreased under stress in both roots and shoots. Salt stress also variedly affected the activities of different enzymes of respiratory chain. The activity of pyruvate dehydrogenase (E.C. 1.2.4.1) decreased in 50 mM NaCl but increased in 100 mM and 150 mM concentrations, in both root and shoot samples. Succinate dehydrogenase (E.C. 1.3.5.1) activity was reduced in root whereas stimulated in shoot under increasing concentrations of salt. The activity of isocitrate dehydrogenase (E.C. 1.1.1.41) and malate dehydrogenase (E.C. 1.1.1.37) decreased in both root and shoot samples under salt stress. On the contrary, pretreatment of mungbean seeds with sublethal dose of NaCl was able to overcome the adverse effects of stress imposed by NaCl to variable extents with significant alterations of all the tested parameters, resulting in better growth and efficient respiration in mungbean seedlings. Thus, plants can acclimate to lethal level of salinity by pretreatment of seeds with sublethal level of NaCl, which serves to improve their health and production under saline condition, but the sublethal concentration of NaCl should be carefully chosen. Copyright © 2012 Elsevier Masson SAS. All rights reserved.

  5. Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

    Directory of Open Access Journals (Sweden)

    Elena V. Tchetina

    2016-01-01

    Full Text Available This study reports the effects of the iron chelator deferoxamine (DFO on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1–50 μM. Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK concentrations were measured using ELISAs. Gene expression studies employed real-time PCR and included AMPK analyses in PBMCs. In OA explants collagen cleavage was frequently downregulated by 10–50 μM DFO. PCR analysis of 7 OA patient cartilages revealed that 10 μM DFO suppressed expression of MMP-1, MMP-13, IL-1β, and TNFα and a marker of chondrocyte hypertrophy, COL10A1. No changes were observed in the expression of glycolysis-related genes. In contrast, expressions of genes associated with the mitochondrial Krebs cycle (TCA, AMPK, HIF1α, and COL2A1 were upregulated. AMPK gene expression was reduced in OA cartilage and increased in PBMCs from the same patients compared to healthy controls. Our studies demonstrate that DFO is capable of suppressing excessive collagenase-mediated type II collagen cleavage in OA cartilage and reversing phenotypic changes. The concomitant upregulation of proanabolic TCA-related gene expressions points to a potential for availability of energy generating substrates required for matrix repair by end-stage OA chondrocytes. This might normally be prevented by high whole-body energy requirements indicated by elevated AMPK expression in PBMCs of OA patients.

  6. MR imaging of the lateral collateral ligaments after ankle sprain; Aussenbandrupturen des Sprunggelenkes - Darstellung mit der MRT vor und nach funktioneller Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Grebe, P. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Kreitner, K.F. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Roeder, W. [Abt. fuer Chirurgie, St-Hildegardis-Krankenhaus, Mainz (Germany); Kersjes, W. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Hennes, R. [Abt. fuer Allgemein- und Unfallchirurgie, St. Josefshospital, Wiesbaden (Germany); Runkel, M. [Unfallchirurgische Klinik der Unversitaetsklinik, Mainz (Germany)

    1995-09-01

    35 patients with ankle sprain were examined by MRI and stress radiographs. 13 were operated afterwards, 22 patients underwent a functional conservative therapy and were examined by MRI and stress radiographs and second time after three months. MRI reports were correct in 12 of 13 operated cases. After conservative therapy we did not find any disrupted ankle ligament. MRI showed intact ligaments thickened by scar. (orig./MG) [Deutsch] 35 Patienten mit klinischem Verdacht auf Aussenbandruptur wurden mit der MRT untersucht. 13 Patienten wurden operiert, 22 konzervativ therapiert. Letztere wurden nach drei Monaten erneut mit MRT und gehaltenen Aufnahmen untersucht. Die MRT-Befunde stimmten in 12 von 13 Faellen mit den operativ erhobenen Befunden ueberein. Nach dreimonatiger konzervativer Therapie waren alle 22 Sprunggelenke stabil. Die rupturierten Baender stellten sich verdickt und durchgaengig dar. (orig./MG)

  7. Radiological findings, evaluation and treatment of patellofemoral pain after total knee arthroplasty; Radiologische Diagnostik, Beurteilung und Behandlung des patellofemoralen Schmerzes nach primaerer Knieendoprothetik

    Energy Technology Data Exchange (ETDEWEB)

    Springorum, H.R.; Keshmiri, A.; Heers, G.; Renkawitz, T.; Grifka, J.; Baier, C. [Asklepios Klinikum Bad Abbach, Orthopaedische Klinik fuer die Universitaet Regensburg, Bad Abbach (Germany)

    2012-11-15

    Total knee arthroplasty (TKA) is one of the most successful operative procedures over the last decades in orthopedic surgery; however, some patients suffer from pain, limited range of motion, instability, infections or other complications postoperatively. Patellofemoral pain (PFP) in particular is a common problem after TKA and often necessitates revision surgery. Mainly increasing and localized contact pressure and patella maltracking are held responsible for PFP but the reasons vary. Diagnostics and therapy of PFP is not easy to manage and should be treated following a clinical pathway. The authors suggest that patients with PFP should be categorized after basic diagnostic measures according to the suspected diagnosis: (1) tendinosis, (2) mechanical reasons, (3) intra-articular non-mechanical reasons and (4) neurogenic/psychiatric reasons. Efficient application of special diagnostic measures and further therapy is facilitated by this classification. (orig.) [German] Die endoprothetische Versorgung des Kniegelenks ist eine Operation mit hohem Zugewinn an Lebensqualitaet. Dennoch sind je nach Literaturstelle bis zu 50% der Patienten von Schmerzen, Bewegungseinschraenkung, Instabilitaet, Infektion oder anderen Komplikationen betroffen. Insbesondere der patellofemorale Schmerz (PFS) ist eine haeufige Komplikation nach primaerer Knieendoprothetik und wird je nach Literatur mit 1-50% der Faelle angegeben. Insbesondere der erhoehte retropatellare Anpressdruck und eine schlechte Fuehrung der Patella werden fuer den PFS verantwortlich gemacht, doch die Ursachen sind vielfaeltig. Diagnostik und Behandlung sind komplex und sollten strukturiert durchgefuehrt werden. Nach der Basisdiagnostik schlagen die Autoren daher eine Einteilung in eine der 4 Gruppen vor: (1) Tendinosen, (2) mechanische Probleme, (3) intraartikulaere nichtmechanische Probleme, (4) neurogene/psychische Probleme. Durch die Einteilung in diese verschiedenen Gruppen werden eine effiziente spezielle

  8. The contribution of MRI to the detection of endovascular aneurysm repair; Wertigkeit der MRT in der Erkennung von Leckagen nach endovaskulaerer Aneurysmaausschaltung

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, S.C.; Goerich, J.; Aschoff, A.J.; Wisianowski, C.; Brambs, H.J. [Ulm Univ. (Germany). Abt. fuer Diagnostische Radiologie; Pamler, R. [Ulm Univ. (Germany). Abt. fuer Gefaess- und Thoraxchirurgie

    2002-10-01

    Purpose: Evaluation of MR-imaging in the follow-up of patients after endovascular repair of abdominal aortic aneurysms concerning detection of endoleaks. Materials and Methods: In the postoperative follow-up after endovascular repair of aortic aneurysms, 10 consecutive patients (mean age: 68 years) were suspected to have an endoleak by helical CT and were scheduled for conventional angiography, preceded by supplemental MR-imaging to confirm or refute the diagnosis. The images of helical CT and MRI were evaluated by two independent readers concerning leak, feeding vessel and artifacts. Results: The follow-up MRI was able to detect all endoleaks (type 1 endoleak, n=7; type 2 endoleak, n=3) compared to all but one detected by helical CT. Of the 10 patients with an endoleak, MR-angiography visualized the feeding vessel in 7 patients and CT in one patient. MRI did show fewer metal artifacts from the stent wire than CT. For the visualization of feeding vessels and endoleaks, MRA achieved statistically significant superiority. In a single case, helical-CT was not reliable because of strange metal artefacts after previous coil embolization. Conclusion: MRI is comparable to helical-CT in detecting endoleaks and superior to CT in demonstrating the anatomy of the feeding vessel after endovascular repair of aortic aneurysms. The major advantages are fewer artifacts after coil embolization and absent radiation exposure. (orig.) [German] Ziel: Evaluation der Magnetresonanztomographie in der Nachsorge von Patienten nach endovaskulaerer Bauchaortenaneurysmaausschaltung in Bezug auf die Erkennung von Leckagen. Material und Methode: Im Zuge von Verlaufskontrollen nach endovaskulaerer, infrarenaler Aortenaneurysmaausschaltung wurden 10 konsekutive Patienten (Durchschnittsalter: 68 Jahre) nach auffaelligem CT-Befund bezueglich Aneurysmagroesse bzw. -perfusion fuer eine angiographische Klaerung vorgesehen. Anschliessend wurde zusaetzlich bei allen Patienten eine Kernspintomographie

  9. Three-phase skeletal scintigraphy: Perfusion and vitality of the femoral head after medial neck fracture and osteosynthesis; 3-Phasen-Skelettszintigraphie: Perfusion und Vitalitaet des Hueftkopfes nach medialer Schenkelhalsfraktur und Osteosynthese

    Energy Technology Data Exchange (ETDEWEB)

    Einert, A. [Abt. Nuklearmedizin, Radiologische Universtaetsklinik Freiburg (Germany); Bonnaire, F. [Abt. Unfallchirurgie, Radiologische Universitaetsklinik Freiburg (Germany); Simon, G.H. [Abt. Nuklearmedizin, Radiologische Universtaetsklinik Freiburg (Germany); Kuner, E. [Abt. Unfallchirurgie, Radiologische Universitaetsklinik Freiburg (Germany); Moser, E. [Abt. Nuklearmedizin, Radiologische Universtaetsklinik Freiburg (Germany)

    1996-09-01

    Perfusion and Vitality of the Femoral Head after Medial Neck Fracture and Osteosynthesis. Aims: To analyse with regard to necrosis the perfusion and vitality of the femoral head after medial neck fracture and repair by placement of a dynamic hip screw. Patients and Methods: Twenty-one patients were examined by scintigraphy immediately following operation as well as at 3 and 6 months postoperative for evaluation of dysfunctions of perfusion and mineralization. Results: Complete perfusion and mineralization defects with a tendency for revasularization at 3 months will be normal at 6 months. Persisting dysfunctions at 3 and 6 months will progress to femoral head necrosis irrespective of the fracture staging. Conclusions: Three-phase skeletal scintigraphy is a highly sensitive, non-invasive method for evaluating perfusion and revascularization of the femoral head after femoral neck fracture and repair by means of a dynamic hip screw. When perfusion of the femoral head is observed one week after the trauma, femoral head necrosis will not arise. Immobilization is necessary after partial or complete perfusion and mineralization dysfunctions until the scintigraphic findings return to normal. The present results may serve as a recommendation for loading after fracture repair with a dynamic hip screw. (orig.) [Deutsch] Ziel: Skelettszintigraphische Verlaufsuntersuchung von Perfusion und Vitalitaet des Hueftkopfes nach medialer Schenkelhalsfraktur und osteosynthetischer Versorgung mit dynamischer Hueftschraube (DHS) bezueglich der Beurteilung einer Hueftkopfenkrose. Material und Methode: Bei 21 Patienten 3-Phasen-Skelettszintigraphie unmittelbar postoperativ sowie nach 3 und 6 Monaten zur Beurteilung von Perfusions- und Mineralisationsstoerungen des Hueftkopfes. Ergebnisse: Teilausfaelle sind nach 3 Monaten ruecklaeufig. Vollstaendige Perfusions- und Mineralisationsdefekte mit Revaskularisierungstendenz nach 3 Monaten normalisieren sich nach 6 Monaten vollstaendig

  10. Klinefelter-Syndrom und Krebs

    Directory of Open Access Journals (Sweden)

    Kliesch S

    2014-01-01

    Full Text Available – Männer mit Klinefelter-Syndrom haben kein erhöhtes Gesamtrisiko für Krebserkrankungen. – Gehäuft treten jedoch das virile Mammakarzinom und extragonadale, meist im Mediastinum lokalisierte Keimzelltumoren auf. Mammakarzinome treten eher bei älteren Männern, Keimzelltumoren meistens vor dem 30. Lebensjahr auf. – Die Daten zu erhöhter Inzidenz bzw. Mortalität bei hämatologischen Neoplasien und bei Bronchialkarzinom sind nicht eindeutig. – Das Risiko für ein Prostatakarzinom ist erniedrigt.

  11. Klinefelter-Syndrom und Krebs

    OpenAIRE

    Kliesch S; Heidemann S; Schorpp F; Wörmann B

    2012-01-01

    - Männer mit Klinefelter-Syndrom haben kein erhöhtes Gesamtrisiko für Krebserkrankungen.br - Gehäuft treten jedoch das virile Mammakarzinom und extragonadale, meist im Mediastinum lokalisierte Keimzelltumoren auf. Mammakarzinome treten eher bei älteren Männern, Keimzelltumoren meistens vor dem 30. Lebensjahr auf.br - Die Daten zu erhöhter Inzidenz bzw. Mortalität bei hämatologischen Neoplasien und bei Bronchialkarzinom sind nicht eindeutig.br - Das Risiko für ein Prostatakarzinom ist erni...

  12. MRI and MRS in patients with silicon implants of the breast; MRT und MRS nach Silikonaufbau der weiblichen Brust

    Energy Technology Data Exchange (ETDEWEB)

    Pfleiderer, B.; Heindel, W. [Muenster Univ. (Germany). Radiologische Klinik und Poliklinik

    2001-07-01

    This paper reviews the evaluation of the breast of women by MR-techniques after implantation with silicon gel protheses. The main topics are the diagnosis of implant defects such as extensive ''gel bleed'' and intra- and extracapsular ruptures. Moreover, the MR-detection of siliconomas (encapsulated silicone) and differentiation from malignomas as well as MR-features of chronic foreign body reactions are presented. ''Gel bleed'' is difficult to diagnose unambiguously by MRI alone. The ''linguini'' sign is the only reliable mans to diagnose intracapsular ruptures. The presence of silicone outside the implant capsule indicates extracapsular rupture. The MR-spectroscopic detection of silicone in the liver suggests after short implantation times and a normal MR scan the diagnosis ''gel bleed'', and after longer implantation times of more than 10 years and missing ''linguini'' sign the diagnosis of ruptures due to a dissolved shell of the implant. MRI, in comparison to other imaging modalities, has the highest specificity and sensitivity in the diagnosis of implant defects. Due to its high costs, however, MR is not suitable as a screening tool and should only be used in cases of sonographic suspected rupture or after radical mastectomy. In these cases MRI is the method of choice. (orig.) [German] In dieser Uebersicht wird die Evaluation der weiblichen Brust nach Aufbau mit Silikonmammaprothesen mittels MR-Techniken vorgestellt. Ein Schwerpunkt liegt dabei auf der Defektdiagnostik, d.h. dem Nachweis des so genannten ''Gelblutens'', der intra- und der extrakapsulaeren Ruptur. Daneben wird auf die MR-Detektion von Silikonomen (abgekapseltes Silikon) und deren Abgrenzung von einem Malignom eingegangen und das typische MR-Erscheinungsbild von chronischer Fremdkoerperreaktion vorgestellt. ''Gelbluten'' ist mittels MR-Bildgebung (MRT

  13. Feministische Gesellschaftstheorie und die Suche nach der Anschlussfähigkeit Feminist Social Theory in Search of Connections

    Directory of Open Access Journals (Sweden)

    Silke Schneider

    2002-07-01

    Full Text Available Der Sammelband „Soziale Verortung der Geschlechter“ stellt einen Querschnitt aktueller feministischer Theoriediskussionen vor. Dass bei der Suche nach angemessenen gesellschaftsanalytischen Kategorien sowohl die Klassiker/-innen der Politischen Theorie und Gesellschaftstheorie wie auch ihre Epigonen mannigfache Kritik-, aber auch vielversprechende Anschlußpunkte zu bieten haben, vermögen alle Beiträge zu vermitteln. Somit bietet der Band mit seiner breit angelegten Konzeption, die wichtige und durchaus gegensätzliche Theorien verbindet, einen guten Überblick und regt gleichzeitig zur vertiefenden Lektüre an. Bemerkenswert ist, dass nahezu alle Beiträge für eine Verbindung von Empirie und Theorie plädieren und hierbei die Einbeziehung einer historischen Perspektive als grundlegend und unabdingbar für eine Analyse der Geschlechterverhältnisse als Teil gesellschaftlicher Entwicklung erachtet wird.The anthology “The Social Positionings of Gender” presents a cross section of current debates in feminist theory. The authors show how authors of classical political and social theory as well as their successors offer plenty of room for criticism, but also promising starting points in the search for appropriate socio-analytic categories. This anthology not only offers a good overview over current theory by connecting different (and at times contradicting schools of thought, but also inspires to engage in further reading on these issues. What is particularly remarkable about this work is that almost all of the contributions plead for a combination of empirical research and theoretical work, as they consider the inclusion of a historical perspective as fundamental and indispensable for an analysis of gender relations as part of societal developments.

  14. Massenmedien und Versöhnung: Die Berichterstattung über den deutsch-französischen Friedensprozeß nach dem 2. Weltkrieg

    Directory of Open Access Journals (Sweden)

    Susanne Jaeger

    2003-10-01

    Full Text Available Der vorliegende Beitrag beinhaltet die ersten Ergebnisse einer Langzeitstudie, bei der flächendeckend die deutsche Nachkriegsberichterstattung über Frankreich von 1946 bis 1970 inhaltsanalytisch ausgewertet wurde. Die Studie stützt sich dabei auf das Modell der Nachrichtenfaktoren von Johan Galtung, welche nach seiner Ansicht die Auswahl der Themen bestimmen, die zu einer Nachricht werden. Genau in diesen Selektionsroutinen liegt jedoch die implizite Gefahr, Konflikte zu vertiefen statt sie einzudämmen bzw. durch ein breites Verständnis der Hintergründe gewaltfrei bearbeitbar zu machen. Für die Zeit nach einem Krieg könnten sie Hindernisse auf dem Weg zur Annäherung und Aussöhnung ehemaliger Gegner darstellen. Wie jedoch sieht die Berichterstattung nach dem Krieg tatsächlich aus? Zeigen Massenmedien Bereitschaft zu einer veränderten Berichterstattung? Der Fall der französisch-deutschen Aussöhnung, welcher als Beispiel für einen gelungenen Aussöhnungsprozess gelten kann, belegt, dass Friedensprozesse von den Medien durchaus adäquat begleitet werden können: Z.B. ist der Anteil "positiver" Themen bzw. Berichterstattung konsistent höher als der "negativer", und der Anteil von Non-Elite-Themen steigt an und kündet von Interesse an französischer Lebensart und Kultur. Die Ergebnisse zeigen, dass Negativismus in den Medien kein Naturgesetz ist, sondern überwunden werden kann, wenn Frieden und Versöhnung auf der Tagesordnung stehen.

  15. Bathymetry and Near-River Topography of the Naches and Yakima Rivers at Union Gap and Selah Gap, Yakima County, Washington, August 2008

    Science.gov (United States)

    Mastin, M.C.; Fosness, R.L.

    2009-01-01

    Yakima County is collaborating with the Bureau of Reclamation on a study of the hydraulics and sediment-transport in the lower Naches River and in the Yakima River between Union Gap and Selah Gap in Washington. River bathymetry and topographic data of the river channels are needed for the study to construct hydraulic models. River survey data were available for most of the study area, but river bathymetry and near-river topography were not available for Selah Gap, near the confluence of the Naches and Yakima Rivers, and for Union Gap. In August 2008, the U.S. Geological Survey surveyed the areas where data were not available. If possible, the surveys were made with a boat-mounted, single-beam echo sounder attached to a survey-grade Real-Time Kinematic (RTK) global positioning system (GPS). An RTK GPS rover was used on a walking survey of the river banks, shallow river areas, and river bed areas that were impenetrable to the echo sounder because of high densities of macrophytes. After the data were edited, 95,654 bathymetric points from the boat survey with the echo sounder and 1,069 points from the walking survey with the GPS rover were used in the study. The points covered 4.6 kilometers on the Yakima River and 0.6 kilometers on the Naches River. GPS-surveyed points checked within 0.014 to 0.047 meters in the horizontal direction and -0.036 to 0.078 meters in the vertical direction compared to previously established survey control points

  16. Modification of the method of Figgie for determination of joint line shifting in total knee arthroplasty; Modifizierung der Messmethode nach Figgie zur Bestimmung der Gelenklinienverschiebung in der Knieendoprothetik

    Energy Technology Data Exchange (ETDEWEB)

    Classen, T.; Wegner, A.; Knoch, M. von [Universitaet Duisburg-Essen, Klinik fuer Orthopaedie, Essen (Germany)

    2009-06-15

    An important factor for a good result after total knee arthroplasty is the position of the patella in relation to the tibiofemoral joint line. The position of the patella itself is not influenced by arthroplasty, therefore any changes in the position of the tibiofemoral joint line are of special interest. The Figgie method to describe patella height delivers only absolute measurements, which makes it difficult to compare different radiographs. For this reason we developed a new JL/P quotient (JL: distance from the tibial plateau to the tibial tubercle, P: distance from the inferior pole of the patella to the tibial plateau) to enable better comparison. Furthermore, we modified the JL/P quotient and instead of taking the tibial plateau as the reference line, we constructed a tangent on the femoral condyle. With this modification, problems such as tibial inlays of different heights which have to be taken into account in the measurements, the slope of the tibial component or difficult assessment of the tibial joint surface in osteoarthritic knees do not arise. The JL/P quotient shows massive shift to cranialisation of the tibiofemoral joint line which does not correspond to reality. The modified method also shows cranialisation of the tibiofemoral joint line, but in a realistic way. Both methods show a minimal interobserver variability. The modified JL/P quotient seems to be a good method for determining the shift in the tibiofemoral joint line after total knee arthroplasty. (orig.) [German] Ein bedeutender Faktor fuer ein gutes postoperatives Ergebnis nach einer Knieendoprothesenimplantation ist die Stellung der Patella in Relation zur tibiofemoralen Gelenklinie. Da die Stellung der Patella durch den operativen Eingriff primaer nicht beeinflusst wird, liegt besonderes Augenmerk auf den Veraenderungen der Gelenklinie des Tibiofemoralgelenks. Die Messmethode zur Bestimmung der Patellahoehe nach Figgie liefert dafuer nur absolute Werte, was eine Vergleichbarkeit von

  17. Einfluss des Ratings von Unternehmen auf die Rechnungslegung und Abschlussprüfung - Rating als Möglichkeit zur Verbesserung des Informationsgehalts des Lageberichts nach § 289 HGB

    OpenAIRE

    Fiebiger, André

    2006-01-01

    Mit der Einführung von Basel II erhalten ab dem 01. Januar 2007 nahezu alle fremdfinan¬zierten Unterneh¬men im Rahmen einer Ratinga¬nalyse eine individuelle Bewertung ihrer Bo¬nität. Wie die Ratinganalyse haben sich auch die gesetzlichen Vertreter im Rahmen der Lageberichterstattung und der Abschlussprüfer im Rahmen seiner Prüfungs¬pflichten mit der Bestandskraft des zu prüfenden Unternehmens auseinander zu setzen. Es stellt sich insofern die Frage nach dem Einfluss von Ratinganalysen auf die...

  18. Erziehung nach Auschwitz

    DEFF Research Database (Denmark)

    2017-01-01

    Auschwitz var det barbari, imod hvilket al opdragelse retter sig. Man taler om truende tilbagefald i barbariet. Men det truer ikke – Auschwitz var tilbagefaldet. Barbariet består stadig – så længe de betingelser, som resulterede i tilbagefaldet, varer ved....

  19. Sacherschliessung nach RDA

    Directory of Open Access Journals (Sweden)

    Hans Schürmann

    2015-05-01

    Full Text Available Die Resource Description and Access (RDA wird für den deutschsprachigen Raum das neue Regelwerk für die bibliothekarische Erschliessung der Bestände. In diesem Regelwerk wird auch die Sacherschliessung neu geregelt. Zurzeit sind diese Seiten noch leer. Doch wie soll ein Regelwerk für die Sacherschliessung aussehen? Kriterien für eine Regelung fehlen, zu stark hat sich das Umfeld der Inhaltserschliessung in den letzten Jahren geändert. Auch von der Schlagworttheorie her sind noch keine Hinweise in Sicht. Deshalb wird in verschiedenen Gremien intensiv diskutiert, wie eine zukunftsfähige Sacherschliessung aussehen könnte. In welchem Rahmen bewegt sich die Diskussion und woran soll sich die Regelwerksentwicklung für den Sachkatalog orientieren? Der Beitrag erwägt zwischen der Sachkataloggeschichte einerseits und dem modernen Datenmanagement im Netz andererseits die Bedeutung und die Rolle eines Sacherschliessungsregelwerks. Resource Description and Access (RDA will be the new standard for descriptive cataloguing in the German-speaking countries. Under RDA, subject indexing will also be redefined, although, at present, the relevant pages remain blank. This article ponders the question what these new standards could look like. As yet no clear criteria have emerged – the field of subject indexing has undergone too much change in recent years for that. Nor does the theory appear to offer any answers at the moment. There is therefore intensive and ongoing debate in the various forums. What is the framework of these discussions and what are the key criteria? The article summarizes them and considers the importance of indexing standards in the light of both the history of indexing and modern data management on the web.

  20. Beginn und Dosisanpassung einer intensivierten konventionellen Insulintherapie (ICT beim Erwachsenen

    Directory of Open Access Journals (Sweden)

    Lohr R

    2012-01-01

    Full Text Available Eine intensivierte Insulintherapie (ICT ist die Behandlung der Wahl bei Diabetes mellitus Typ 1 und auch bei vielen Menschen mit insulinpflichtigem Typ-2-Diabetes. Bei Therapiebeginn müssen individuell Insuline ausgewählt und die richtige Dosierung festgelegt werden. Im weiteren Verlauf ist dann die Anpassung der Insulintherapie an besondere Alltagssituationen wie Sport oder akute Erkrankungen vorrangig. Eine gute Patientenschulung und eine gute Zusammenarbeit zwischen Betroffenem und Behandlerteam sind entscheidend, um diese komplizierte Therapie erfolgreich umzusetzen.

  1. Imaging of appendicitis in adults; Bildgebung der Appendizitis beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Karul, M.; Berliner, C.; Keller, S.; Yamamura, J. [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Diagnostic and Interventional Radiology; Tsui, T.Y. [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of General, Visceral- and Thoracic Surgery

    2014-06-15

    Three imaging modalities are available for the diagnosis of acute appendicitis: ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Transabdominal ultrasound should be the first-line imaging test. Abdominal CT is superior to US and is required immediately in patients with atypical clinical presentation of appendicitis and suspected perforation. However, low-dose unenhanced CT is equal to standard-dose CT with intravenous contrast agents in the detection of five signs of acute appendicitis (thickened appendiceal wall more than 2 mm, cross-sectional diameter greater than 6 mm, periappendicitis, abscess, and appendicolith). MRI is necessary in pregnant women and young adults. This review illustrates the principles of state-of-the-art imaging techniques and their clinical relevance. (orig.)

  2. Radiation therapy after mastectomy. Interdisciplinary consensus puts an end to a controversy; Strahlentherapie nach Mastektomie. Interdisziplinaerer Konsensus beendet Kontroverse

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, R. [Erlangen-Nuernberg Univ., Erlangen (Germany). Klinik und Poliklinik fuer Strahlentherapie; Schulz, K.D. [Marburg Univ. (Germany). Medizinisches Zentrum fuer Frauenheilkunde und Geburtshilfe; Hellriegel, K.P. [Krankenhaus Berlin-Moabit (DE). 2. Innere Klinik] [and others

    2001-01-01

    . Gesicherte Indikationen zur postoperativen Radiotherapie nach Mastektomie sind: T3/T4-Karzinome, T2-Karzinome mit einer Groesse>3 cm, multizentrisches Tumorwachstum, Lymphangiosis carcinomatosa oder Gefaesseinbrueche, Befall der Pektoralisfaszie oder Sicherheitsabstand<5 mm, R1- oder R2-Resektion, mehr als drei befallene Achsellymphknoten. Als sinnvolle, aber noch nicht in klinischen Studien evaluierte Indikationen gelten: Multifokalitaet, extensive intraduktale Komponente, Rezeptornegativitaet, Malignitaetsgrad G3, diffuse Mikrokalzifikationen, ein bis drei axillaere Lymphknotenmetastasen, Zustand nach mehreren, nicht in sano erfolgten Biopsien, Alter unter 35 Jahre. 4. Eine simultan zur Radiotherapie durchgefuehrte Tamoxifenbehandlung ist entgegen teilweise anderslautenden In-vitro-Daten durchaus sinnvoll, zumal Tamoxifen die Apoptose foerdert. Eine CMF-Therapie wird ueblicherweise im Sandwich-Verfahren durchgefuehrt, kann jedoch in begruendeten(orig.)(abstract truncated)

  3. Mechanical-biological waste conditioning with controlled venting - the Meisenheim mechanical-biological waste conditioning plant; Mechanisch-biologische Restabfallbehandlung nach dem Kaminzugverfahren - MBRA Meisenheim

    Energy Technology Data Exchange (ETDEWEB)

    Hangen, H.O. [Abfallwirtschaftsbetrieb Landkreis Bad Kreuznach, Bad Kreuznach (Germany)

    1998-12-31

    The decision of the rural district of Bad Kreuznach to propose creating facilities for mechanical-biological waste conditioning at the new northern Meisenheim landfill was consistent and correct. It will ensure that the material deposited at this new, state-of-the-art landfill is organically `lean` and can be deposited with a high density. Preliminary sifting of the material prior to depositing safeguards that no improper components are inadvertently included. Three years of operation warrant the statement that waste components that cannot be appropriately biologically conditioned should be eliminated prior to rotting. (orig.) [Deutsch] Die Entscheidung des Landkreises Bad Kreuznach, der neu eingerichteten Norddeponie Meisenheim eine MBRA vorzuschlaten, war auf jeden Fall konsequent und richtig. Es ist damit sicher gestellt, dass in diesem neuen nach dem Stand der Technik eingerichteten Deponiebereich von Anfang an ein Material eingelagert wird, das `organisch abgemagert` ist und mit hoher Einbaudichte eingebaut werden kann. Die Sichtung des gesamten Deponie-Inputs in der Vorsortierhalle gibt ein Stueck Sicherheit, dass keine nicht zugelassenen Stoffe verdeckt dem Ablagerungsbereich der Deponie zugefuehrt werden. Nach mehr als 3 Jahren Betriebszeit kann festgestellt werden, dass biologisch nicht sinnvoll behandelbare Abfallbestandteile vor dem Rotteprozess abgetrennt werden sollten. (orig.)

  4. The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

    Directory of Open Access Journals (Sweden)

    Urszula Baranowska

    2017-07-01

    Full Text Available α7-nACh is one of the major nicotinic cholinergic receptor subtypes found in the brain. It is broadly expressed in the hippocampal and cortical neurons, the regions which play a key role in memory formation. Although α7-nACh receptors may serve as postsynaptic receptors mediating classical neurotransmission, they usually function as presynaptic modulators responsible for the release of other neurotransmitters, such as glutamate, γ-aminobutyric acid, dopamine, and norepinephrine. They can, therefore, affect a wide array of neurobiological functions. In recent years, research has found that a large number of agonists and positive allosteric modulators of α7-nAChR induce beneficial effects on learning and memory. Consistently, mice deficient in chrna7 (the gene encoding α7-nAChR protein, are characterized by memory deficits. In addition, decreased expression and function of α7-nAChR is associated agoniwith many neurological diseases including schizophrenia, bipolar disorder, learning disability, attention deficit hyperactivity disorder, Alzheimer disease, autism, and epilepsy. In the recent years many animal experiments and clinical trials using α7-nAChR ligands were conducted. The results of these studies strongly indicate that agonists and positive allosteric modulators of α7-nAChR are promising therapeutic agents for diseases associated with cognitive deficits.

  5. Intracoronary radiation for the prevention of restenosis following PTCA; Intrakoronare Bestrahlung zur Verhinderung einer Restenose nach PTCA

    Energy Technology Data Exchange (ETDEWEB)

    Silber, S. [Kardiologische Praxis in der Klinik Dr. Mueller, Muenchen (Germany)

    2001-12-01

    . Behandlung einer nach Ballondehnung von Koronarstenosen in ca. 30% auftretenden Restenose durch intravaskulaere Bestrahlung beruht auf der jeder Strahlentherapie inhaerenten Proliferationshemmung. Insgesamt liegen 12 plazebokontrollierte, randomisierte Studien vor: 7 bei In-Stent-Restenose, 2 bei De-novo-Stenosen (oder Restenosen ohne Stent) als striktes Einschlusskriterium und 3 mit allen Stenosearten. In diesen 12 Studien wurden 1676 Patienten den Plazebogruppen und 1794 den Therapiegruppen zugeordnet. Bei den In-Stent-Restenosen lag die Gefaessgroesse als Einschlusskriterium zwischen 2,4 mm und 5,5 mm, die Stenosenlaenge zwischen < 20 mm und {<=} 80 mm. In allen Studien mit In-Stent-Restenosen wurden die primaeren Endpunkte erreicht, die Restenoseraten im laengsten analysierten Koronarsegment lagen in den Kontrollgruppen zwischen 45% und 68,8% und in den Brachytherapiegruppen zwischen 21% und 53,5%. Die entsprechenden Werte fuer die TVR lagen in den Kontrollgruppen zwischen 24,1% und 67,6%, in den Brachytherapiegruppen zwischen 16% und 41,7%. MACE in den Kontrollgruppen lag zwischen 25,9% und 67,6%, in den Brachytherapiegruppen zwischen 18% und 41,7%. Bei De-novo-Stenosen waren die Ergebnisse problematisch, da das 'geographic miss' hier eine groessere Rolle zu spielen scheint. Unter Beruecksichtigung dieser Tatsache liessen sich jedoch auch bei De-novo-Stenosen gute Resultate erzielen. Die bekannten Limitationen durch spaete Stentthrombosen (in aelteren Studien 4-15%) und durch Randeffekte konnten durch eine einjaehrige Clopidogrelgabe bzw. die Verwendung laengerer Strahlenquellen weitgehend beseitigt werden. Bei De-novo-Stenosen ist in Anbetracht der antiproliferativ beschichteten Stents jetzt nicht mehr mit einer wichtigen Rolle der intrakoronaren Brachytherapie zu rechnen. Im Gegensatz hierzu stellt die intrakoronare Brachytherapie bei In-Stent-Restenose die einzige evidenzbasierte interventionelle Therapieform dar. (orig.)

  6. Functional MRI of the pelvic floor: postpartum changes of primiparous women after spontaneous vaginal delivery; Funktionelle Magnetresonanztomographie (MRT) des Beckenbodens: Postpartale Veraenderungen bei Erstgebaerenden nach vaginaler Spontangeburt

    Energy Technology Data Exchange (ETDEWEB)

    Lienemann, A.; Fischer, T.; Reiser, M. [Inst. fuer Klinische Radiologie, Klinikum der Univ. Muenchen (Germany); Anthuber, C. [Klinik und Poliklinik fuer Geburtshilfe und Frauenheilkunde, Klinikum der Univ. Muenchen/Grosshadern (Germany)

    2003-08-01

    Purpose: Detection of morphological and functional changes of the pelvic floor with functional MRI in primiparous women after spontaneous vaginal delivery. Methods and Materials: The study comprises 26 primiparous women after vaginal delivery and a control group of 41 healthy asymptomatic nulliparous volunteers. MRI was performed on a 1.5 T system in supine position with vagina and rectum opacified with Sonogel. The static images consisted of sagittal and axial T{sub 2}-weighted SE sequences and functional images of true FISP sequences in midsagittal and axial planes acquired with the patient at rest, straining and during defecation. Evaluation of morphometric parameters included pelvimetry, thickness of the puborectal muscle and width of the urogenital hiatus as well as position and movement of the pelvic organs relative to the pubococcygeal reference line. Results: The configuration of the bony pelvis did not differ for both groups. The puborectal muscle was significantly thinner in the study group (0.8 cm vs 0.6 cm). The functional images showed no significant differences between both groups at rest but a significantly increased incidence in the descent of the bladder neck, vaginal fornix and anorectal junction in the study group during straining. In addition, the primiparous women had more prominent rectoceles (0.6 cm vs 1.5 cm). Conclusion: Static imaging alone fails to demonstrate relevant pelvic floor changes and a functional method is necessary to evaluate the interactions of the pelvic organs regarding organ descent. Functional MRI of the pelvic floor is an excellent method to reveal the significant changes of the pelvic floor after vaginal birth without exposing the uterus to radiation. (orig.) [German] Ziel: Darstellung von morphologischen und funktionellen Veraenderungen am Beckenboden bei Erstgebaerenden nach spontanvaginaler Entbindung mittels funktioneller MRT. Methodik: Funktionelle MRT des Beckenbodens von 26 Erstgebaerenden nach vaginaler

  7. The value of ultrasound and MRI following surgical treatment of repture of the achilles tendon; Der Wert von Ultraschall und Magnetresonanztomographie in der postoperativen Verlaufskontrolle nach Achillessehnenruptur

    Energy Technology Data Exchange (ETDEWEB)

    Rominger, M.B.; Bachmann, G. [Giessen Univ. (Germany). Abt. fuer Diagnostische Radiologie; Schulte, S.; Zedler, A. [Giessen Univ. (Germany). Orthopaedische Klinik

    1998-01-01

    Aim: A comparison of clinical examination, sonography and MRI in the follow-up of suture of the Achilles tendon. Method: 60 patients were examined in a prospective study for 6-78 months following suture of the Achilles tendon repair; both sides were compared clinically and sonographically; in 30 patients MRI was also used. Morphometric measurements (antero-posterior and transverse measurements) and changes in morphological structure were correlated with clinical results. Results: All patients showed thickening of the Achilles tendon postoperatively. Morphometric and morphological changes showed positive and significant correlation between sonography and MRI (p=<0.001, p=0.004). Structural changes in sonography had positive correlation with general symptoms (p=<0.001), pain on movement (p=<0.001), reduced function (p=0.005), and reduced sporting activity (p=0.034). MRI findings showed significant regression with time (p=0.05). Conclusion: Following repair, the Achilles tendon remained thickened throughout the period of observation. Post-operative changes in the structure of the tendon regressed partially. Sonography and MRI correlate significantly with the clinical findings. Sonography is the imaging method of choice, MRI is an additional procedure. (orig.) [Deutsch] Ziel: Vergleich von Klinik, Sonographie und MRT in der Verlaufsbeobachtung nach Achillessehnennaht. Methodik: In einer prospektiven Untersuchung wurden 60 Patienten im Seitenvergleich 6-78 Monate nach Achillessehnennaht klinisch, sonographisch und 30 Patienten magnetresonanztomographisch nachuntersucht. Morphometrische (anterior-posteriorer (a.-p.) und Querdurchmesser) und morphologische Strukturveraenderungen wurden mit den klinischen Ergebnissen korreliert. Ergebnisse: Alle Patienten (n=60) wiesen postoperativ eine verdickte Achillessehne auf. Morphometrische und morphologische Veraenderungen in Sonographie und MRT korrelierten positiv signifikant (p=<0,001, p=0,004). Sonographische

  8. Veno-occlusive liver disease after infradiaphragmatic total lymphoid irradiation. A rare complication; Die Venenverschlusskrankheit der Leber nach infradiaphragmaler total lymphatischer Bestrahlung. Eine seltene Nebenwirkung

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, M.; Zierhut, D.; Gutwein, S.; Wannenmacher, M. [Heidelberg Univ. (DE.) Abt. fuer Klinische Radiologie - Schwerpunkt Strahlentherapie; Hansmann, J. [Heidelberg Univ. (DE.) Abt. fuer Radiologische Diagnostik; Stremmel, W.; Mueller, M. [Heidelberg Univ. (DE). Abt. Innere Medizin 4 (Schwerpunkt Gastroenterologie)

    2001-06-01

    -jaehrigen Patienten mit einem zentrozytisch-zentroblastischen Non-Hodgkin-Lymphom, Stadium IA (Lokalisation: Linke Leiste) wurde die gesamte Abdomen- und Beckenregion ('abdominelles Bad') bestrahlt. Bei einer woechentlichen Fraktionierung von fuenfmal 1,5 Gy wurde eine Gesamtdosis von 30 Gy appliziert. Zum Schutz der Risikoorgane wurden Nierenbloecke nach 13,5 Gy und Leberbloecke nach 25 Gy eingesetzt. Waehrend der letzten beiden Therapietage kam es zur Verschlechterung des Allgemeinzustandes des Patienten mit Gewichtszunahme, Vergroesserung des Bauchumfanges, Dyspnoe und einem Anstieg der Leberwerte. Die weiterfuehrende Diagnostik ergab eine Hepatosplenomegalie mit ausgepraegter Aszitesbildung und einen erhoehten portosystemischen Druckgradienten. Im Leberbiopsat wurde eine Venenverschlusskrankheit gefunden. Innerhalb 1 Woche nach Anlage eines transjungulaeren intrahepatischen portosystemischen Stent-Shunts (TIPSS), Vollheparinisierung und unter Diuretikagabe war der Patient beschwerdefrei. Die Leberwerte sind im Normbereich. Schlussfolgerung: Die Venenverschlusskrankheit der Leber (VOD) ist eine sehr seltene Nebenwirkung bei der abdominellen Bestrahlung nicht vorbehandelter follikulaerer Keimzentrumslymphome. Bei Oberbauchbeschwerden, Anstieg der Leberenzyme sowie Aszitesbildung, insbesondere in einem Zeitraum von bis zu 4 Monaten nach Therapieabschluss, muss an diese Komplikation gedacht werden. Genese, Diagnostik und Therapie der Venenverschlusskrankheit der Leber werden im Literaturueberblick praesentiert. (orig.)

  9. An old paper revisited: "a mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load" by V.V. Dynnik, R. Heinrich and E.E. Sel'kov.

    Science.gov (United States)

    Nazaret, Christine; Mazat, Jean-Pierre

    2008-06-07

    We revisit an old Russian paper by V.V. Dynnik, R. Heinrich and E.E. Sel'kov (1980a,b) describing: "A mathematical model of carbohydrate energy metabolism. Interaction between glycolysis, the Krebs cycle and the H-transporting shuttles at varying ATPases load". We analyse the model mathematically and calculate the control coefficients as a function of ATPase loads. We also evaluate the structure of the metabolic network in terms of elementary flux modes. We show how this model can respond to an ATPase load as well as to the glucose supply. We also show how this simple model can help in understanding the articulation between the major blocks of energetic metabolism, i.e. glycolysis, the Krebs cycle and the H-transporting shuttles.

  10. Universal energy ratings for Germany - (Part 2): Evolution of rating distributions according to year of building construction; Universelle Energiekennzahlen fuer Deutschland - Teil 2: Verbrauchskennzahlentwicklung nach Baualtersklassen

    Energy Technology Data Exchange (ETDEWEB)

    Greller, Martin [BRUNATA Waermemesser GmbH and Co. KG, Muenchen (Germany); Schroeder, Franz; Papert, Olaf [METRONA Waermemesser Union GmbH, Muenchen (Germany); Hundt, Volker [BRUNATA Waermemesser Hagen GmbH and Co. KG, Hamburg (Germany); Mundry, Bernhard [Brunata Waermemesser-Gesellschaft Schultheiss GmbH and Co., Huerth (Germany)

    2010-02-15

    vergangenen sechs Jahren. Deren Datenaufbereitung umfasst die rueckwirkende Revision respektive Normierung aller Energiekennzahlen anhand neuer ortsgenauer Klimafaktoren des Deutschen Wetterdienstes. Eine Auswahl von 110.000 Energiekennzahlen von gas- und oelbeheizten Gebaeuden - davon etwa die Haelfte mit Baujahr nach 1977 - werden statistisch gemaess ihrer Kennzahlenentwicklung nach Baualtersklassen aufgeschluesselt. Betrachtet wurden dabei nur nominell waermetechnisch unsanierte Mehrfamilienhaeuser bis 1994 und Neubauten ab 1995. Es wird belegt, dass die Mediane der heutigen Energiekennzahlverteilungen der bis in die 1960-er Jahre gebauten Gebaeude relativ konstant um 155 kWh/(m2a) liegen. Fuer diesen Bauzeitraum fallen die Energiekennzahlen fuer rund 90 % des Bestandes (5 bis 95 % Quantil) zwischen 100 und 260 kWh/(m2a). Seitdem fallen die Mediane stetig auf aktuell bis 85 kWh/(m2a). Der staerkste relative Rueckgang ergibt sich fuer die Baujahre von 1994 nach 1995 mit Inkrafttreten der Waermeschutzverordnung 1995. Die Standardabweichungen der Verteilungen haben sich gegenueber den Gebaeuden aus den 1960-er Jahren von ueber 50 kWh/(m2a) bis auf heute an naehernd 25 kWh/(m2a) etwa halbiert. Eine Gegenueberstellung der empirisch ermittelten Verbrauchskennzahlverteilungen mit den typischen Mindestanforderungen der vergangenen Waermeschutzverordnungen und aktuellen Energieeinsparverordnungen schliessen sich an. Mathematische Parametrierungen der empirischen Kennzahlverteilungen fuer Modell- und Hochrechnungen der Energieeffizienzentwicklung werden mitgeliefert. (Abstract Copyright [2010], Wiley Periodicals, Inc.)

  11. Use of recombinant, human TSH radioiodine therapy in patients with differentiated thyroid carcinoma; Radioiodtherapie des differenzierten Schilddruesenkarzinoms nach Vorbehandlung mit rekombinantem, humanem TSH

    Energy Technology Data Exchange (ETDEWEB)

    Luster, M. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2001-12-01

    Hypothyreose behandelt. Ein Patient litt neben einem papillaeren Schilddruesenkarzinom an einer sekundaeren Hypothyreose, ein Patient wurde wegen einer hypophysaeren Metastase und insuffizienter TSH-Produktion nach Radiatio ueberwiesen. Die Behandlung erfolgte nach einem standardisierten Regime: An 2 aufeinander folgenden Tagen wurden jeweils 0,9 mg rhTSH intramuskulaer verabreicht, gefolgt von der oralen Applikation von 1000-7000 MBq I-131 an Tag 3. Bei allen Patienten liess sich eine maximale TSH-Stimulation (>80 mU/l) erreichen, unerwuenschte Nebenwirkungen wurden nicht beobachtet. Im weiteren Verlauf kam es bei 7 Patienten zu einem deutlichen Abfall des Tg-Spiegels 1-4 Monate nach Therapie, 7 Patienten zeigten einen Progress der Erkrankung, hiervon verstarben 3, die in einem praefinalen Stadium behandelt worden waren, in einem Zeitraum von 1-3 Monaten. Zusammenfassend ist festzustellen, dass rekombinantes TSH ein hilfreiches Instrument bei der Behandlung dieses schwierigen Patientenkollektivs darstellt, dennoch kann die infauste Prognose einiger Patienten mit aggressivem Tumorwachstum nicht positiv beeinflusst werden. (orig.)

  12. Echocardiographic changes after mantle-irradiation. Results obtained in a group of patients at Erlangen; Kardiale Spaetfolgen nach Mantelfeldbestrahlung. Ergebnisse im Erlanger Patientenkollektiv

    Energy Technology Data Exchange (ETDEWEB)

    Friedrich, S.A. [Univ. Erlangen-Nuernberg, Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik; Unverdorben, M. [Univ. Erlangen-Nuernberg, Erlangen (Germany). Medizinische Klinik 2 und Poliklinik; Kunkel, B. [Univ. Erlangen-Nuernberg, Erlangen (Germany). Medizinische Klinik 2 und Poliklinik; Dunst, J. [Univ. Erlangen-Nuernberg, Erlangen (Germany). Strahlentherapeutische Klinik und Poliklinik

    1996-01-01

    Morbus Hodgkin erkrankte Patienten (Alter 39,8{+-}13 Jahre), die sich in den Jahren 1979 bis 1984 einer Mantelfeldbestrahlung (Mediastinaldosis 41,8{+-}7 Gy), zum Teil in Kombination mit Chemotherapie (n=19), unterzogen hatten, wurden untersucht. Die Nachbeobachtungszeit nach Primaertherapie betrug fuenf bis elf Jahre. Das Untersuchungsprogramm umfasste Anamnese, koerperliche Untersuchung, Farb-Doppler-Echokardiographie und Fahrradergometrie. Als Vergleichskollektiv dienten 122 nichtbestrahlte Patienten und Probanden der kardiologischen Ambulanz (Alter 46,1{+-}16 Jahre). Zeichen einer klinisch manifesten kardialen Funktionseinschraenkung ergaben sich nicht. In 26% fand sich eine Perikardverdickung. Eine Ruhetachykardie (Frequenz >100) bestand bei 30% der Patienten, erhoehte Blutdruckwerte bei 33%. Die linksventrikulaere Ejektionsfraktion war normal. Allerdings fanden sich Veraenderungen der diastolischen Parameter: Die Verkuerzungsfraktion war im Vergleich zum Kontrollkollektiv signifikant vermindert (p<0,05), ebenso die fruehdiastolische Relaxationszeit (p<0,05). Ischaemiezeichen (5%), Reizleitungsstoerungen (7%) und Rhythmusstoerungen (7%) waren nicht gehaeuft. Nach Mantelfeldbestrahlung zeigten die Patienten in dieser Nachuntersuchung innerhalb der ersten zehn Jahre nach Therapie nur minimale kardiologische Veraenderungen. Der sensitivste Parameter ist die echokardiographische Messung der fruehdiastolischen Relaxationszeit. Die klinische Relevanz dieser Befunde ist bisher unklar. Eine kardiologische Kontrolle von Patienten in Langzeitremission erscheint indiziert. (orig./MG)

  13. RESEARCH ON THE INFLUENCE OF H+ IONS CONCENTRATION ON THE DYNAMICS OF THE ACTIVITIES OF CERTAIN DEHYDROGENASES OF THE KREBS CYCLE IN THE MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS PARASITIC ON PLUM TREES

    Directory of Open Access Journals (Sweden)

    Tutu Elena

    2010-09-01

    Full Text Available During the process of nutrition, thus in that of their growth, microorganisms are subject to the influences of certain environmental factors that condition the microbial activity determining either the growth and reproduction, or the inhibition of activity and the inactivation of microorganisms. A well known means of expressing the H+ ions concentration in a certain environment is the pH, an important chemical factor that is closely observed when growing ascomycetes, for any alteration of its value entails conformational alterations of their enzymes, the characteristics of the substrate, such that they can no longer interact with the active site of the enzyme or be subject to catalysis. The present study comprises the results of our research on certain oxidoreductase implied in the steps of the Krebs cycle in the Monilinia laxa (Aderh.&Ruhl. Honey, a fungus that parasites the prune. The enzymatic determinations took place at 7 and 14 days from the mycelium of the fungus cultivated in Leonian media, whose pH was adjusted to values between 2.0 and 9.0 by using NaOH 1N and HCl 0,1N solutions. We registered different values of the dehydrogenasic activity, directly correlated with the physiological condition of the fungus (given its age and with the initial pH value of the culture’s environment.

  14. Activation of blood clotting and fibrinolysis in angiocardiography with ionic and non-ionic contrast medium; Aktivierung von Blutgerinnung und Fibrinolyse nach Angiokardiographie mit ionischem und nichtionischem Kontrastmittel

    Energy Technology Data Exchange (ETDEWEB)

    Winkler, U.H. [Gerinnungsphysiologisches Lab., Zentrum fuer Frauenheilkunde, Universitaetsklinikum Essen (Germany); Park, J.W. [Herz-Zentrum Kaiser-Wilhelm-Krankenhaus, Duisburg (Germany); Weber, S. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany); Kothe, A. [Gerinnungsphysiologisches Lab., Zentrum fuer Frauenheilkunde, Universitaetsklinikum Essen (Germany); Schnitker, J. [Inst. fuer Angewandte Statistik GmbH, Bielefeld (Germany); Behrends-Steins, B. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany); Albring, M. [Schering AG, Geschaeftsbereich Deutschland, Berlin (Germany)

    1997-06-01

    Purpose: To study the effects of a ionic (amidotrizoate) and a nonionic X-ray contrast medium (iopromid) during routine levocardiography and coronary angiography, we employed assays that detect reaction products of thrombin and plasmin to assess the activation of the haemostatic system. Methods: Subsequent to informed consent, 20 patients were randomly assigned to receive either amidotrizoate or iopromid during standard levocardiography and coronary angiography in a double-blind comparative study. Groups were comparable in respect of age, weight, sex and severity of the disease. No anticoagulation was provided. Coronary angiography was performed according to a standardised protocol. Consumption of contrast media and duration of the examination were comparable in both groups. Results: Thrombin generation (F.1+2) and thrombin activity (TAT) were higher with the ionic contrast medium but did not attain statistical significance. Fibrin generation and degradation as expressed by D-dimer fibrin split products was significantly increased in patients who had been receiving amidotrizoate (p<0,05, U-Test). Conclusion: The non-ionic X-ray contrast medium induced significantly less haemostatic activation in vivo than did the ionic medium amidotrizoate. These data suggest that earlier in vitro observations of more pronounced anticoagulant effects of ionic X-ray contrast media are of limited significance for the evaluation of in vivo effects of X-ray contrast media on haemostatic function. (orig.) [Deutsch] Ziel: Bestimmung der Aktivitaet des haemostatischen Systems in vivo nach Gabe von ionischem und nichtionischem Roentgenkontrastmittel in der Angiokardiographie. Material und Methoden: In eine randomisierte doppelblinde Vergleichsstudie mit den Kontrastmitteln Amidotrizoat und Iopromid wurden 20 Patienten (10 pro Gruppe) einbezogen. Bei der aus medizinischen Gruenden indizierten Angiokardiographie wurden 5 repraesentative Reaktionsprodukte der thrombin- und plasmininduzierten

  15. Radiologic assessment of the outcome of Keller and Brandes arthroplasty for hallux rigidus; Hallux rigidus operiert nach Keller und Brandes: Radiologische Erfolgs- und Prognoseparameter

    Energy Technology Data Exchange (ETDEWEB)

    Breitenseher, M.J. [Abt. fuer Osteologie, Universitaetsklinik fueer Radiodiagnostik und Besondere Klinische Einrichtung Magnet Resonanz, Wien (Austria)]|[Ludwig-Boltzmann-Institut fuer Radiologische Tumordiagnostik, Wien (Austria); Toma, C.D. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Gottsauner-Wolf, F. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Imhof, H. [Abt. fuer Osteologie, Universitaetsklinik fueer Radiodiagnostik und Besondere Klinische Einrichtung Magnet Resonanz, Wien (Austria)]|[Ludwig-Boltzmann-Institut fuer Radiologische Tumordiagnostik, Wien (Austria)

    1996-06-01

    The aim of this study was to evaluate the pre- and postoperative radiographic findings of hallux rigidus treated with Keller and Brandes arthroplasty to determine the radiographic outcome and to identify a prognostic marker. 83 patients with a total of 121 cases of hallux rigidus operated using Keller and Brandes arthroplasty were followed up (mean 9.7 y). A comparison of the pre- and postoperative radiographs, the clinical and subjective findings was predicated on a five point scale: 1. Percentage of proximal phalanx resected (<33%, 33-50%, >50%), 2. joint space, 3. ratio of the length of the first and second metatarsals, 4. first intermetatarsal angle, and 5. hallux valgus angle. In the patient group which had 33-50% of the proximal phalanx excised (n=67. 55%) the highest patient satisfaction was observed (96%). If resection of the proximal phalanx exceeded 50% (n=13. 11%), non physiologic dorsiflexion of the toe occurred and patients were unsatisfied (62%). Excision of less than 33% of the hallux (n=41. 34%) was associated with a recurrent hallux rigidus. No other evaluated radiological parameter proved to be of significance. The most important radiological parameter in the evaluation of the outcome of Keller and Brandes arthroplasty as the percentage of the proximal phalanx which had ben excised. (orig.) [Deutsch] Ziel der Studie war es, auf prae- und postoperativen Roentgenbildern des Hallux rigidus radiologische Parameter zu ermitteln, die den Erfolg der Arthroplastik nach Keller und Brandes abschaetzen und von prognostischer Relevanz sind. 121 Hallux-rigidus-Operationen bei 83 Patienten wurden nachuntersucht (9,7 a). 5 Kriterien wurden an den prae- und postoperativen Roentgenbildern ausgewertet: 1. Anteil der Grosszehengrundgliedresektion in Prozent (<33%, 33-50%, >50%), 2. Gelenkspaltbreite, 3. Laengenverhaeltnis von erstem und zweitem Metartasalknochen, 4. erster Intermetatarsalwinkel und 5. Hallux-valgus-Winkel und mit den klinischen Ergebnissen

  16. Zu den gesetzlichen Grundlagen der Lehrerbildung in Japan und zu EU- und Deutschlandbild nach der Wiedervereinigung in japanischen Schulbüchern für höhere Schulen

    OpenAIRE

    Hillenbrand, Hans (Prof.)

    1997-01-01

    Zu den gesetzlichen Grundlagen der Lehrerbildung in Japan und zu EU- und Deutschlandbild nach der Wiedervereinigung in japanischen Schulbüchern für höhere Schulen. - In: Die Geographiedidaktik ist tot, es lebe die Geographiedidaktik : Festschr. zur Emeritierung von Josef Birkenhauser / hrsg. von Friedhelm Frank ... - München, 1997. - S. 95-110. - (Münchner Studien zur Didaktik der Geographie ; 8)

  17. Beijing Bubble, Beijing Bust: Inequality, Trade, and Capital Inflow into China Beijing Blase, Beijing Krise: Ungleichheit, Handel und Kapitalzufluss nach China

    Directory of Open Access Journals (Sweden)

    James K. Galbraith

    2009-07-01

    Full Text Available This paper explores the relationships between inequality, trade, and capital flows into China since the early 1990s and particularly in the first years of the present decade. We show that the rise in economic inequality in China has more to do directly with the activities associated with China’s financial and building boom, notably in Beijing, than with the massive growth in manufacturing employment and in Chinese exports since China joined the WTO in 2001. Nevertheless, it is likely that a flow of profits from the export boom did feed the speculative fires in the capital and elsewhere, and therefore it should be no surprise that the fall of one should be linked to the fall of the other, in a particularly painful reduction of economic inequality. In diesem Artikel werden die Beziehungen zwischen Ungleichheit, Handel und Kapitalzufluss nach China seit den frühen 1990er Jahren untersucht. Es wird aufgezeigt, dass die steigende wirtschaftliche Ungleichheit in China weit mehr mit Chinas Finanz- und Bauboom insbesondere in Beijing zu tun hat als mit dem großen Anstieg der Beschäftigung in der Produktion und in Chinas Exporten seit dem WTO-Beitritt im Jahr 2001.

  18. Intrafascial hematoma of the musculus rectus abdominis as a complication after laparoscopic operations; Intrafasziale Haematome des Musculus rectus abdominis als Komplikation nach laparoskopischen Operationen

    Energy Technology Data Exchange (ETDEWEB)

    Pennekamp, W. [Radiologische Universitaetsklinik am St. Josef-Hospital, Bochum (Germany); Barbera, L. [Chirurgische Universitaetsklinik am St. Josef-Hospital, Bochum (Germany)

    1998-01-01

    We report on two patients with intrafascial hematoma of the musculus rectus abdominis following laparoscopic operations. One patient was operated on a stenosis of the common iliac artery for an aortofemoral bypass. The other patient was operated on an inguinal hernia. Only a CT scan of the abdomen led to the correct diagnosis, because the use of ultrasound was limited by pneumoperitoneum and bandages, and retroperitoneal bleeding could not be recognized. Computed tomography is a valid method for detecting this complication of laparoscopic surgery. (orig.) [Deutsch] Es wird ueber zwei Patienten berichtet, die nach einer laparoskopischen Operation ein intrafasziales Haematom des Musculus rectus abdominis entwickelten. Bei einem Patienten wurde laparoskopisch ein aortofemoraler Bypass bei hochgradiger A.-iliaca-communis-Stenose, bei dem anderen Patienten ein laparoskopischer Bruchlueckenverschluss bei einer Inguinalhernie durchgefuehrt. Erst die Computertomographie des Abdomens fuehrte in beiden Faellen zur richtigen Diagnose, da Ultraschall aufgrund des Pneumoperitoneous und der Verbandsmaterialien nur bedingt einsetzbar war und retroperitoneale Blutungsansteile nicht erkannt werden konnten. Der Stellenwert der Computertomographie zur Erkennung dieser Komplikation wird hervorgehoben. (orig.)

  19. Suche nach Sleptonen und leptonisch zerfallenden Charginos in $e^+ e^-$ Kollisionen bei Schwerpunktsenergien bis zu 184 GeV mit dem ALEPH-Detektor

    CERN Document Server

    Van Gemmeren, P

    1998-01-01

    In den Jahren 1996 und 1997 konnte der ALEPH--Detektor bei Schwerpunktsenergien zwischen 161 GeV und 184 GeV Daten mit einer integrierten Luminosit"at von mehr als 80 pb^-1 aufzeichnen. Diese Daten wurden nach einem "Uberschu"s an Ereignissen mit acoplanaren Leptonen untersucht. Da sowohl deren Anzahl als auch deren Ereignisgr"o"sen mit der Standardmodell- erwartung gut vertr"aglich sind, kann die Produktion von Selektronen, Smyonen und Charginos, falls diese leptonisch zerfallen, f"ur bestimmte Massenkombi- nationen mit einem Vertrauensinterval von $95\\%$ ausgeschlossen werden: - Rechtsh"andige Selektronen m"ussen schwerer als 81 GeV/c^2 sein, falls die Massendifferenz zum leichtesten Neutralino Delta m mindestens 10 GeV/c^2 gro"s ist. - F"ur Selektronen mit Delta m > 5 GeV/c^2 (Delta m > 3 GeV/c^2) wird eine untere Grenze von 74 GeV/c^2 (68 GeV/c^2) gefunden. - Rechtsh"andige Smyonen m"ussen schwerer als 71 GeV/c^2 sein, falls die Massendifferenz mindestens 5 GeV/c^2 betr"agt. Hierbei wird ein Verzweigungs-...

  20. Mycotic aneurysm of the superior mesenteric artery after septic embolism; Entwicklung eines mykotischen Aneurysmas der A. mesenterica superior nach septischer Embolie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F.; Dinkel, H.P. [Institut fuer Diagnostische Radiologie, Inselspital, Universitaetsklinik Bern (Switzerland)

    2002-07-01

    Mycotic aneurysms of the aorta and the visceral arteries are life-threatening diseases, due to potential rupture and organ or limb ischemia. They occur in endocarditis, immunodeficiency, bacteremia and fungemia, and have a poor prognosis.We report on a case of a 54-year-old male patient suffering from abdominal angina after mitral valve replacement for septic mycotic endocarditis. In presence of a mycotic-embolic occlusion of the left popliteal artery and multiple septic organ infarctions a mycotic aneurysm of the superior mesenteric artery was found in abdominal spiral-CT.Based on sequential spiral-CT examinations, this case demonstrates the development of a septic aneurysm of the superior mesenteric artery. (orig.) [German] Mykotische Aneurysmen der Aorta und ihrer Aeste stellen wegen Rupturgefahr und moeglicher Minderperfusion von Organen und Extremitaeten eine lebensgefaehrliche Erkrankung mit unguenstiger Prognose dar. Beguenstigende Faktoren sind geschwaechte Immunabwehr, Endokarditis, Bakteriaemie und Fungaemie.Wir berichten ueber einen 54-jaehrigen Patienten, der nach einem Mitralklappenersatz bei mykotischer Endokarditis zunehmende abdominelle Beschwerden im Sinne einer Angina abdominalis entwickelte. Die abdominelle Spiralcomputertomographie zeigte ein mykotisches Aneurysma der A. mesenterica superior. Daneben bestanden ein mykotischer Verschluss der linken A. poplitea und multiple septische Organinfarkte.Der Fall demonstriert anhand sequentieller Computertomographien eindrucksvoll die Entwicklung eines septischen Viszeralarterienaneurysmas. (orig.)

  1. Alar ligaments: radiological aspects in the diagnosis of patients with whiplash injuries; Stellenwert bildgebender Verfahren in der Diagnostik der Ligg. alaria nach Beschleunigungsverletzung der Halswirbelsaeule

    Energy Technology Data Exchange (ETDEWEB)

    Muhle, C. [Klinik fuer Nuklearmedizin, Christian-Albrechts-Univ. zu Kiel (Germany); Brossmann, J.; Biederer, J.; Jahnke, Th.; Grimm, J.; Heller, M. [Klinik fuer Diagnostische Radiologie, Christian-Albrechts-Univ. zu Kiel (Germany)

    2002-04-01

    Post-traumatic changes of the alar ligaments have been proposed to be the cause of chronic pain in patients after whiplash injury of the cervical spine. In addition to an asymmetric dens position, widening of the atlantodental distance to more than 12 mm can be an indirect sign of an alar ligament rupture. CT is recommended for detection of a avulsion fracture of the occipital condyle. Isolated ruptures of the alar ligaments are best visualized on MRI. In patients with chronic impairments after whiplash injuries changes of the alar ligaments on MRI must be differentiated from normal variants in healthy individuals. (orig.) [German] Posttraumatische Veraenderungen der Ligg. alaria werden als ursaechlich fuer chronische Beschwerden bei Patienten mit Beschleunigungsverletzungen der Halswirbelsaeule angesehen. Eine asymmetrische Densposition sowie eine Erweiterung der anterioren atlantoaxialen Distanz auf ueber 12 mm koennen auf konventionellen Roentgenaufnahmen ein indirektes Zeichen fuer das Vorliegen einer Fluegelbandverletzung sein. Die Computertomographie ist die Methode der Wahl zum Nachweis einer kondylaeren Ausrissfraktur des Lig. alare. Isolierte akute Bandverletzungen der Ligg. alaria sind hingegen in der MRT direkt nachweisbar. Bei Patienten mit chronischen Beschwerden nach Beschleunigungsverletzungen der Halswirbelsaeule muessen allerdings morphologische Auffaelligkeiten der Ligg. alaria im MRT von Normvarianten abgegrenzt werden. (orig.)

  2. Effekte spezifischer Interventionen im Sportunterricht auf die exekutiven Funktionen von Primarschulkindern

    OpenAIRE

    Schmidt, Mirko; Jäger, Katja; Roebers, Claudia M.; Conzelmann, Achim

    2014-01-01

    Einleitung Die Annahme, dass Sport nicht nur positive Effekte auf die körperliche Gesundheit, sondern auch auf die kognitive Leistung haben kann, konnte anhand experimenteller Studien mit Erwachsenen weitgehend bestätigt werden. Ob dieselben Effekte auch bei Kindern und Jugendlichen vorzufinden sind, kann mit Blick auf die mangelnde empirische Evidenz in dieser Altersgruppe kaum zufriedenstellend beantwortet werden (Chang et al., 2012). Will man zudem der Frage nach den Wirkmechanismen nac...

  3. Persistent inflammation and tumour response in rats after intratracheal installation of high doses of coal dusts, Ti dioxide and quartz; Chronische Entzuendung und Tumorbildung in Ratten nach intratrachealer Instillation hoher Dosen von Kohlenstaeuben, Titandioxid und Quarz

    Energy Technology Data Exchange (ETDEWEB)

    Borm, P.J.A.; Hoehr, D.; Steinfartz, Y.; Zeittraeger, I.; Albrecht, C. [Heinrich-Heine Univ., Duesseldorf (Germany). Medizinisches Inst. fuer Umwelthygiene

    2001-10-01

    The aim of this study was to investigate persistent inflammation and tumor response in the rat after intratracheal instillation of two coal dust samples and other dust preparations. Female Wistar rats (190 gr) were instilled with ground lean coal (60 mg), coal mine dust (60 mg), DQ12 quartz (5 mg) and fine (60 mg) and ultrafine (30 mg) TiO{sub 2}. After 129 weeks rats were killed, tumors detected by macroscopy, and inflammation by immunohistochemistry using specific antibody staining for macrophages and granulocytes. Increased alveolar macrophages (AM) and interstitial granulocytes were still present in dust treated animals. Both AM and granulocytes per surface area were related to tumor incidence when all materials were plotted in one graph, and can be interpreted as effects of overload. Differences in tumor formation between fine and ultrafine TiO{sub 2}, despite similar inflammatory response, are probably caused by a direct effect of ultrafine TiO{sub 2} after interstitialisation. It is concluded that coal dust is another poorly soluble, non-toxic dust, which at high enough dose-rate causes overload, inflammation and tumor response in the rat. (orig.) [German] Das Ziel dieser vorliegenden Studie war die Untersuchung der persistierenden Entzuendung und Tumorantwort in Ratten nach der intratrachealen Instillation von zwei verschiedenen Kohlenstaeuben und anderer Staubpraeparationen. Weiblichen Wistarratten (190 g) wurde Kohlenstaub (Quarzgehalt <0,1%, 60 mg), Gesteinsstaub (Quarzgehalt 16,7%, 60 mg), DQ12 Quarz (5 mg) sowie feinen (60 mg) und ultrafeinen (30 mg) Titandioxid instilliert. Nach 129 Wochen wurden die Ratten getoetet, die Lungen makroskopisch auf Tumoren untersucht und die Entzuendung nach spezifischer Antikoerperfaerbung gegen Makrophagen und neutrophile Granulozyten immunohistochemisch bestimmt. Ein Anstieg an Alveolarmakrophagen (AM) und interstitiellen Granulozyten wurde in den staubbehandelten Ratten nachgewiesen. Die Zahl der AM und der

  4. Antioxidant properties of Krebs cycle intermediates against malonate pro-oxidant activity in vitro: a comparative study using the colorimetric method and HPLC analysis to determine malondialdehyde in rat brain homogenates.

    Science.gov (United States)

    Puntel, Robson Luiz; Roos, Daniel Henrique; Grotto, Denise; Garcia, Solange C; Nogueira, Cristina Wayne; Rocha, Joao Batista Teixeira

    2007-06-13

    A variety of Krebs cycle intermediaries has been shown to possess antioxidant properties in different in vivo and in vitro systems. Here we examined whether citrate, succinate, malate, oxaloacetate, fumarate and alpha-ketoglutarate could modulate malonate-induced thiobarbituric acid-reactive species (TBARS) production in rat brain homogenate. The mechanisms involved in their antioxidant activity were also determined using two analytical methods: 1) a popular spectrophotometric method (Ohkawa, H., Ohishi, N., Yagi, K., 1979. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry 95, 351-358.) and a high performance liquid chromatographic (HPLC) procedure (Grotto, D., Santa Maria, L. D., Boeira, S., Valentini, J., Charão, M. F., Moro, A. M., Nascimento, P. C., Pomblum, V. J., Garcia, S. C., 2006. Rapid quantification of malondialdehyde in plasma by high performance liquid chromatography-visible detection. Journal of Pharmaceutical and Biomedical Analysis 43, 619-624.). Citrate, malate, and oxaloacetate reduced both basal and malonate-induced TBARS production. Their effects were not changed by pre-treatment of rat brain homogenates at 100 degrees C for 10 min. alpha-Ketoglutarate increased basal TBARS without changing malonate-induced TBARS production in fresh and heat-treated homogenates. Succinate reduced basal--without altering malonate-induced TBARS production. Its antioxidant activity was abolished by KCN or heat treatment. Fumarate reduced malonate-induced TBARS production in fresh homogenates; however, its effect was completely abolished by heat treatment. There were minimal differences among the studied methods. Citrate, oxaloacetate, malate, alpha-ketoglutarate and malonate showed iron-chelating activity. We suggest that antioxidant properties of citrate, malate and oxaloacetate were due to their ability to cancel iron redox activity by forming inactive complexes, whereas alpha-ketoglutarate and malonate pro

  5. The suppression of aberrant crypt multiplicity in colonic tissue of 1,2-dimethylhydrazine-treated C57BL/6J mice by dietary flavone is associated with an increased expression of Krebs cycle enzymes.

    Science.gov (United States)

    Winkelmann, Isabel; Diehl, Daniela; Oesterle, Doris; Daniel, Hannelore; Wenzel, Uwe

    2007-07-01

    Colorectal cancer is the second leading cause of cancer deaths worldwide with diet playing a prominent role in disease initiation and progression. Flavonoids are secondary plant compounds that are suggested as protective ingredients of a diet rich in fruits and vegetables. We here tested whether flavone, a flavonoid that proved to be an effective apoptosis inducer in colon cancer cells in culture, can affect the development of aberrant crypt foci (ACFs) in C57BL/6J mice in vivo when preneoplastic lesions were induced by the carcinogen 1,2-dimethylhydrazine (DMH). Flavone applied at either a low dose (15 mg/kg body wt per day) or a high dose (400 mg/kg body wt per day) reduced the numbers of ACFs significantly, independent of whether it was supplied simultaneously with the carcinogen (blocking group) or subsequent to the tumor induction phase (suppressing group). Proteome analysis performed in colonic tissue samples revealed that flavone treatment increased the expression of a number of Krebs cycle enzymes in the suppressing group and this was associated with reduced crypt multiplicity. It suggests that mitochondrial substrate oxidation is increased by flavone in colonic cells in vivo as already observed in HT-29 cells in vitro as the prime mechanism underlying tumor cell apoptosis induction by flavone. In conclusion, flavone reduces the number of ACFs in DMH-treated mice at doses that can be achieved for flavonoids by a diet rich in fruits and vegetables. Moreover, reduction in crypt multiplicity by flavone is most probably due to the preservation of a normal oxidative metabolism.

  6. Short-term CT findings after osteosynthesis of fractures of the vertebral spine; Kurzfristige Veraenderungen in der Computertomographie nach osteosynthetischer Versorgung von Wirbelsaeulenfrakturen

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, R.J.; Noor, J.; Herzog, H.; Roettgen, R.; Hidajat, N.; Felix, R. [Klinik fuer Strahlenheilkunde, Charite, Campus Virchow-Klinikum, Humboldt-Univ. zu Berlin (Germany); Klinik fuer Unfall- und Wiederherstellungschirurgie, Charite, Campus Virchow-Klinikum, Humboldt-Univ. zu Berlin (Germany); Pflugmacher, R.; Maeurer, J. [Radiologie am Prinzregentenplatz, Muenchen (Germany)

    2004-05-01

    Veraenderungen insbesondere degenerativer Art zu evaluieren. Material und Methode: Es wurden die prae- und postoperativen computertomographischen Untersuchungen von 55 Patienten (43 Maenner, 12 Frauen, Alter: 7 - 73 Jahre, x = 37,7 Jahre) mit traumatischen.Wirbelsaeulenfrakturen retrospektiv ausgewertet, welche mittels Fixateur-interne-Anlage operativ stabilisiert wurden. Der Abstand von der Operation zur ersten postoperativen CT-Nach-untersuchung betrug maximal eine Woche, zur kurzfristigen zweiten 6 bis 24 Monate (Mittelwert: 10,3 {+-} 2,7 Monate). Die von zwei Radiologen im Konsens erstellten Befunde der kurzfristigen postoperativen CT-Untersuchungen wurden mit den prae- und unmittelbar postoperativen CT-Befunden sowie den klinisch-neurologischen Befunden verglichen und statistisch mittels des Chi-Quadrat- oder des Fisher's-Exact-Tests analysiert. Ergebnisse: Es fand sich kein statistisch signifikanter Zusammenhang zwischen dem Patientenalter und dem Auftreten von Osteoporose, Spondylarthrose, Skoliose, Spondylolisthesis oder Bandscheibenveraenderungen nach posttraumatischer operativer Stabilisierung mittels eines Fixateurs interne (p > 0,05). Ebenfalls ergab sich keine statistisch nachweisbare Abhaengigkeit zwischen der Frakturart, Frakturlokalisation, dem Bestehen eines Polytraumas, dem Operationsweg oder der angewandten Instrumentierung und dem Auftreten einer postoperativen degenerativen Veraenderung an den angrenzenden Segmenten. Ein Hinweis, dass eine Mehrsegmentstabilisierung oder mehrere vorangegangene Wirbelsaeulenoperationen fuer Degenerationen praedestinieren, wurde in der vorliegenden Arbeit nicht gefunden (p > 0,05). Als einziger Risikofaktor erwies sich das Vorliegen einer Rotationsberstungsfraktur vom Typ C1.3, bei der es vermehrt zu einer postoperativen skoliotischen Fehlhaltung bei allerdings nur geringer Fallzahl in dieser Gruppe kam. (orig.)

  7. A broken krebs cycle in macrophages.

    Science.gov (United States)

    O'Neill, Luke A J

    2015-03-17

    Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a systems approach for unbiased analysis of cellular metabolism that reveals key metabolites and metabolic pathways required for distinct macrophage polarization states. Copyright © 2015 Elsevier Inc. All rights reserved.

  8. [Annemarie Stiedl. Auf nach Wien! Die mobilität des mitteleuropäischen Handwerks im 18. und 19. Jahrhundert am Beispiel der Haupt- und Residenzstadt] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2009-01-01

    Arvustus: Stiedl, Annemarie. Auf nach Wien! Die mobilität des mitteleuropäischen Handwerks im 18. und 19. Jahrhundert am Beispiel der Haupt- und Residenzstadt. Sozail- und wirtschaftshistorische Studien. Bd. 30. Wien, 2003. Teose põhisisu moodustab 18. ja 19. sajandi linnakäsitööliste rände ruumiliste muutuste ja nihete jälgimine. Autor on võtnud vaatluse alla peamiselt neli käsitööametit : lihunikud, korstnapühkijad, siidist asjakeste valmistajad ning nahast kottide ja mappide valmistajad

  9. Die Beurteilung der Wirksamkeit der BEMER-Therapie bei der körperlichen Regeneration nach dem Ausdauertraining. Case study = The evaluation of the efficacy of BEMER therapy in the physical recovery after endurance training

    OpenAIRE

    Mrozkowiak, Mirosław

    2016-01-01

    Mrozkowiak Mirosław. Die Beurteilung der Wirksamkeit der BEMER-Therapie bei der körperlichen Regeneration nach dem Ausdauertraining. Case study = The evaluation of the efficacy of BEMER therapy in the physical recovery after endurance training. Case study. Journal of Education, Health and Sport. 2016;6(4):399-428. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.50580 http://ojs.ukw.edu.pl/index.php/johs/article/view/3493   The journal has had 7 points in Ministry of Science ...

  10. Die Jagd nach dem Allerkleinsten

    CERN Multimedia

    Wolter, Uwe

    2006-01-01

    Only with probes and telescopes scientists do not explore the universe. To understand the processes in the cosmos, researchers feign Big Bang in gigantic devices and look with extremely sensitive detectors for the most elementary particles (1 page)

  11. Die Suche nach den Gottesteilchen

    CERN Multimedia

    2007-01-01

    2008 wird der größte jemals gebaute Teilchenbeschleuniger in Betrieb genommen Anlässlich des Mathematik-Jahres 2008 hat der Experimentalphysiker der Universität Hamburg und der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, die Bedeutung des Dialogs zwischen Naturwissenschaftlern und Philosophen hervorgehoben.

  12. Global CO{sub 2} emissions 2015. Trend reversion is still waiting, despite hopeful approaches; Weltweite CO{sub 2}-Emissionen 2015. Trendwende laesst trotz hoffnungsvoller Ansaetze nach wie vor auf sich warten

    Energy Technology Data Exchange (ETDEWEB)

    Ziesing, Hans-Joachim

    2016-10-15

    By 2015, global CO{sub 2} emissions were virtually unchanged from 2014 according to provisional calculations. On the whole, a slight increase may have resulted, which has slowed the growth of the past few years. In the previous year alone, the weakest growth since the beginning of the century had been recorded, with only 0.7% of the upturn (with the exception of the crises in 2008/2009). As a result, CO{sub 2} emissions in 2015 were only slightly higher than in the previous year, at 33.1 billion tonnes. A global trend reversal is still likely, but the CO{sub 2} emissions have declined in many countries, particularly in some industrialized countries. [German] Im Jahr 2015 haben sich die weltweiten CO{sub 2}-Emissionen nach vorlaeufigen Berechnungen gegenueber 2014 praktisch nicht veraendert. Insgesamt duerfte sich allenfalls ein leichtes Plus ergeben haben, womit der Zuwachs der vergangenen Jahre erneut gebremst wurde. Schon im Vorjahr war mit einem Plus von nur 0,7 % der bis dahin (mit Ausnahme der Krisenjahre 2008/2009) schwaechste Anstieg seit Beginn des Jahrhunderts zu verzeichnen gewesen. Im Ergebnis blieben die CO{sub 2}-Emissionen 2015 mit reichlich 33,1 Mrd. t nur geringfuegig ueber dem Niveau des Vorjahres. Eine weltweite Trendwende steht wohl noch nach wie vor aus, doch sind immerhin die CO{sub 2}-Emissionen in zahlreichen Laendern, insbesondere in etlichen Industrielaendern, gesunken.

  13. The Prevalence of Power-Sharing: Exploring the Patterns of Post-Election Peace Die Verbreitung von Power-Sharing: Bedingungen für eine friedliche Entwicklung nach Wahlen

    Directory of Open Access Journals (Sweden)

    Anna K. Jarstad

    2009-01-01

    Full Text Available Why are some elections followed by armed conflict, while others are not? This article begins to explore this question by mapping the prevalence of power-sharing agreements and patterns of post-election peace in states shattered by civil war. While democracy builds on the notion of free political competition and uncertain electoral outcomes, power-sharing reduces the uncertainty by ensuring political power for certain groups. Nevertheless, new data presented in this article – the Post-Accord Elections (PAE data collection – shows that the issues of peace, power-sharing and democracy have become intertwined as the vast majority of contemporary peace agreements provide for both power-sharing and elections. First, in contrast to previous research which has suggested that power-sharing is a tool for ending violence, this study shows that conflict often continues after an agreement has been signed, even if it includes provisions for power-sharing. Second, this investigation shows no evidence of power-sharing facilitating the holding of elections. On the contrary, it is more common that elections are held following a peace process without power-sharing. Third, a period of power-sharing ahead of the elections does not seem to provide for postelection peace. Rather, such elections are similarly dangerous as post-accord elections held without a period of power-sharing. The good news is that power-sharing does not seem to have a negative effect on post-election peace. Warum folgt auf Wahlen in manchen Fällen ein bewaffneter Konflikt, in anderen nicht? Die Autorin nähert sich der Antwort auf diese Frage, indem sie die Verteilung von Machtteilungsabkommen und Friedensbedingungen nach Wahlen in Bürgerkriegsstaaten untersucht. Während Demokratie auf der Vorstellung freien politischen Wettbewerbs und offener Wahlergebnisse basiert, reduziert Power-Sharing (Machtteilung diese Offenheit, indem bestimmten Gruppen politische Macht zugesichert wird. Aktuelle

  14. Comparison of the measured specific activities of cesium in mushrooms, pine tree twigs, blueberries, honey and game in Aachen after 1986; Vergleich der gemessenen spezifischen Cs-Aktivitaeten in Mykorrhizapilzen, Fichtenzweigen, Heidelbeeren, Waldhonig sowie Wildfleisch in Aachen nach 1986

    Energy Technology Data Exchange (ETDEWEB)

    Bonka, H.; Schmelz, G. [Technische Hochschule Aachen (Germany). Lehrgebiet Strahlenschutz in der Kerntechnik

    1998-07-01

    After the nuclear reactor accident at Chernobyl the specific activity in mushrooms originating from the region of Aachen was continuously measured until today. At the same time the specific activity was determined in pine tree twigs, blueberries, honey and game. There is a strong connection of the living organisms and the inanimate environment within the forest ecosystem. The decrease of the specific caesium activity in living organisms is slower than in the other environment. (orig.) [German] Nach dem Kernreaktorunfall in Tschernobyl wurde bis heute die spezifische Aktivitaet in Pilzen aus der Umgebung von Aachen gemessen. Parallel hierzu wurde sie in Fichtenzweigen, Heidelbeeren, Waldhonig und Wildfleisch ermittelt. Es zeigt sich eine starke Kopplung der lebenden Organismen und der unbelebten Umwelt im Waldoekosystem. In lebenden Organismen ist der Abfall der spezifischen Cs-Aktivitaet langsamer als in der uebrigen Umwelt. (orig.)

  15. Recall dermatitis caused by reexposition of decotaxel following irradiation of the brain. Case report and review of literature; Recall-Dermatitis durch Docetaxel-Reexposition nach Gehirnbestrahlung. Fallbeobachtung und Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Giesel, B.U.; Kutz, G.G.; Thiel, H.J. [Klinikum Bamberg (Germany). Klinik fuer Strahlentherapie und Radioonkologie

    2001-09-01

    -Hals-Region integriert. Hierbei muss gerade in der palliativen Situation einer Verstaerkung der Nebenwirkungen durch Interaktion der einzelnen Therapiekomponenten besondere Aufmerksamkeit geschenkt werden. Wir berichten deshalb ueber eine schwere Recall-Dermatitis, die wir bei zwei Patientinnen mit einem Mammakarzinom nach Gehirnbestrahlung und anschliessender Reexposition mit Docetaxel beobachtet haben. Patienten und Methode: Von Januar bis Maerz 1999 wurden an unserer Klinik zwei Patientinnen mit bereits fortgeschritten metastasiertem Mammakarzinom wegen neu aufgetretener Gehirnmetastasierung bzw. Meningeosis carcinomatosa einer Ganzhirnbestrahlung unterzogen (2 Gy fuenfmal woechentlich bis zu einer Referenzdosis von 50 Gy). Beide Patientinnen wurden seit Oktober bzw. November 1998 mehrfach mit Docetaxel (Taxotere {sup cirledR}) 30 mg/m{sup 2} Koerperoberflaeche (KOF) woechentlich bzw. 100 mg/m{sup 2} KOF monatlich behandelt. Nach Abschluss der Bestrahlung wurde die Docetaxel-Behandlung fortgesetzt. Ergebnisse: Von beiden Patientinnen wurde Docetaxel vor und waehrend der Bestrahlung gut vertragen. Erst nach Abschluss der Bestrahlung und Docetaxel-Reexposition kam es reproduzierbar zu einem massiven Erythem im Bereich der gesamten bestrahlten Kopfhaut mit Ausbildung feuchter Epitheliolysen und Krustenbildung (CTC-Grad IV). Schlussfolgerung: Die in unseren beiden Faellen beobachtete Dermatitis nach Bestrahlung und Docetaxel-Reexposition ist Ausdruck eines Recall-Phaenomens. Der zugrunde liegende Pathomechanismus ist derzeit noch nicht vollstaendig geklaert. Es bleibt zu untersuchen, inwieweit die Taxane mit der Strahlentherapie - auch im Hinblick auf zukuenftige primaere Radiochemotherapiekonzepte - kombiniert werden koennen, ohne schwerwiegende Toxizitaeten im Bereich der strahlenexponierten Haut oder Schleimhaut auszuloesen. (orig.)

  16. Male gonadal dose an adjuvant 3-D-pelvic irradiation after anterior resection of rectal cancer. Influence to fertility; Radiogene Hodenbelastung durch Streustrahlung bei adjuvanter 3-D-Beckenbestrahlung nach anteriorer Resektion beim Rektumkarzinom. Einfluss auf die Fertilitaet

    Energy Technology Data Exchange (ETDEWEB)

    Piroth, M.D.; Hensley, F.; Wannenmacher, M.; Zierhut, D. [Radiologische Klinik der Univ. Heidelberg (Germany). Abt. fuer Klinische Radiologie

    2003-11-01

    Maenner erkranken. Wir untersuchten die radiogene Hodenbelastung durch Streustrahlung bei adjuvanter Beckenbestrahlung nach Operation eines Rektumkarzinoms. Die gemessenen Strahlendosen am Hoden wurden zu den Daten der Literatur in Beziehung gesetzt. Patienten und Methode: Wir fuehrten bei 18 Patienten mit thermolumineszenzdetektoren (TLD) In-vivo-Messungen zur Bestimmung der streustrahlenbedingten Gonadendosis durch. Die TLDs wurden an vier definierten Punkten des Skrotums fixiert. Die Bestrahlung erfolgte 3-D-geplant in Drei-Felder-Technik in Bauchlage im Lochbrett. Die Gesamtdosis betrug 50,4 Gy, die Einzeldosis 1,8 Gy taeglich. Nach 45 Gy erfolgte eine Modifikation der Bestrahlungstechnik auf opponierende und kranial verkuerzte Gegenfelder zur kompletten Duenndarmschonung. Ergebnisse: Die mittlere Gonadendosis aller 18 Patienten pro Bestrahlungsfraktion betrug 0,057 Gy (median 0,05 Gy), wobei die Mittelwerte der einzelnen Patienten zwischen 0,035 und 0,114 Gy lagen. Die Standardabweichung betrug 0,02 Gy. Nach 28 Fraktionen, 50,4 Gy entsprechend, errechnete sich kumulativ eine Gesamtdosis am Hoden von 1,60 Gy (0,98-3,19 Gy). Schlussfolgerungen: Das maennliche Keimepithel reagiert auf Bestrahlung ausserordentlich sensibel im Sinne eines negativen Fraktionierungseffektes. Bei Gesamtdosen > 1,5 Gy, fraktioniert appliziert, gilt die Azoospermie als meist irreversibel. Die von uns ermittelte Gonadendosis fuehrt nach den Daten der Literatur sehr wahrscheinlich zu einer dauerhaften Sterilitaet. Wegen der geringen Patientenanzahl sind die Daten vorsichtig zu interpretieren, dennoch muss der Patient ueber die hohe Wahrscheinlichkeit einer bleibenden Infertilitaet aufgeklaert werden. Eine moegliche praetherapeutische Spermakryokonservierung sollte mit dem Patienten besprochen werden. (orig.)

  17. AOX determination in industrial waste water according to EN 1485, DEV H14. Experience with high salt freights and interfering organic matter; AOX-Bestimmungen in Industrieabwaessern nach EN 1485, DEV H14 Erfahrungen mit hohen Salzfrachten und organischen Stoerstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, B. [Technische Univ. Muenchen, Garching (Germany). Lehrstuhl und Pruefamt fuer Wasserguete- und Abfallwirtschaft

    1999-07-01

    AOX determination in industrial waste water is not always trivial on account of high salt freights or high organic loads. Interfering substances of inorganic or organic nature can cause increases or decreases of readings that often are not plausible or reproducible. In most cases the AOX enrichment step is limiting to quantitative analysis. In the present work, enrichment in two industrial waste waters was critically assessed according to EN 1485 DEV H14. In addition, experience with the enrichment method according to Dr. Lange is reported. For the elimination of high salt freights beside a low organic concentration, cleanup by means of solid-phase extraction is considered. The results suggest that the standardized procedure is not universally applicable to any type of sample. However, appropriate action can minimize flaws of enrichment and, thereby, AOX determination. (orig.) [German] Die AOX-Bestimmung aus Industrieabwaessern ist aufgrund hoher Salzfrachten oder hoher organischer Belastungen nicht immer trivial. Stoerstoffe anorganischer wie auch organischer Art koennen zu Mehr- oder Minderbefunden fuehren, die oft nicht plausibel und reproduzierbar sind. In den meisten Faellen ist der Anreicherungsschritt des AOX fuer die quantitative Analyse limitierend. In der vorliegenden Arbeit wurde die Anreicherung nach den EN 1485 DEV H14 fuer zwei Industrieabwaesser kritisch betrachtet. Zudem werden Erfahrungen mit der Anreicherungsmethode nach Dr. Lange vorgestellt. Zur Entfernung hoher Salzfrachten neben einer geringen organischen Konzentration wurde ein Clean-up mittels Festphasenextraktion betrachtet. Die Ergebnisse legen nahe, dass das genormte Verfahren nicht universell auf jeden Probentyp anwendbar ist. Durch ein gezieltes Vorgehen koennen jedoch Fehler bei der Anreicherung und damit bei der AOX-Bestimmung minimiert werden. (orig.)

  18. Functional CT imaging of the lung in the axial and coronal plane after single-lung transplantation; Computertomographische Funktionsuntersuchung der Lunge nach einseitiger Lungentransplantation mit axialer und koronarer Akquisition

    Energy Technology Data Exchange (ETDEWEB)

    Kauczor, H.U. [Mainz Univ. (Germany). Klinik fuer Radiologie; Buchenroth, M. [Mainz Univ. (Germany). 3. Medizinische Klinik - Pneumologie; Heussel, C.P. [Mainz Univ. (Germany). Klinik fuer Radiologie; Mayer, E. [Mainz Univ. (Germany). Klinik fuer Herz-, Thorax-, Gefaesschirurgie

    1996-05-01

    After single-lung transplantation in a patient suffering from obstructive emphysema lung function parameters worsened during follow-up. To conplement the routine high-resolution CT (HRCT) scans acquired in inspiration, additional scans were obtained to evaluate regional lung function. The comparison of HRCT scans acquired in inspiration and in expiration revealed different ventilation conditions of both lungs, continuous acquisition in a single slice (dynamic multiscan acquisition) in the axial and coronal plane demonstrated mediastinal shifting and the movement of the diaphragm during the whole breathing cycle. Both modalities can provide important information concerning regional differences of ventilation after single-lung transplantation. Expiratory HRCT should be applied on a regular basis in the follow-up of patients after single-lung transplantation. Expiratory HRCT should be applied on a regular basis in the follow-up of patients after single-lung transplantation. The application of axial and coronal dynamic multiscan acquisitions will be helpful in particular clinical conditions, like increasing hyperinflation, mediastinal shifting or bronchial collapse within the region of the anastomosis. (orig.) [Deutsch] Nach Einzellungentransplantation wegen eines obstruktiven Emphysems wurden bei einem Patienten in der Nachsorge zur Abklaerung einer Verschlechterung der Lungenfunktionsparameter neben einer hochaufloesenden CT (HRCT) in Inspiration zusaetzliche Aufnahmen zur Funktionsbeurteilung durchgefuehrt. Der Vergleich von HRCT-Aufnahmen in In- und Exspiration zeigte die unterschiedlichen Ventilationsverhaeltnisse bei beiden Lungen; kontinuierliche Aufnahmen in einer Schicht (Multirotationsaufnahmen) stellten bei axialer und insbesondere bei direkter koronarer Akquisition die Mediastinal- und Zwerchfellbewegung waehrend des gesamten Atemzyklus dar. Beide Verfahren koennen wichtige Zusatzinformationen ueber regionale Ventilationsdifferenzen nach einseitiger

  19. Local recurrent and metastatic malignant melanoma. Long-term results and prognostic factors following percutaneous radiotherapy; Lokal rezidiviertes und metastasiertes malignes Melanom. Langzeitergebnisse und Prognosefaktoren nach perkutaner Radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Seegenschmiedt, M.H. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Strahlentherapie; Alfried-Krupp-von-Bohlen-und-Halbach-Krankenhaus, Essen (Germany). Klinik fuer Radioonkologie, Strahlentherapie und Nuklearmedizin; Keilholz, L.; Pieritz, A.; Urban, A.; Sauer, R. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Strahlentherapie; Altendorf-Hofmann, A.; Hohenberger, W. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Chirurgie; Schell, H. [Erlangen-Nuernberg Univ. (Germany). Klinik fuer Dermatologie

    1999-09-01

    subtype had no impact. In multivariate analysis, UICC stage was the only independent favorable prognostic factor for achievement of CR and long-term survival (p<0.001). Conclusion: External RT provides effective palliation in advanced UICC stages. The UICC staging system is a good predictor of initial and long-term tumor response in metastatic MM. Prospective randomized trials using RT with or without adjuvant therapy for advanced MM are justified. (orig.) [German] Hintergrund: Die perkutane Radiotherapie wird oft nur als 'Ultima ratio' bei Patienten mit fortgeschrittenem malignen Melanom (MM) eingesetzt. Unsere Studie wertet 20 Jahre klinische Erfahrungen bei fortgeschrittenem, rezidivierten und metastasierten malignen Melanom sowie Endpunkte und Prognosefaktoren aus. Patienten und Methodik: Von 1977 bis 1995 wurde bei 121 Patienten (56 Frauen, 65 Maennern) von 2 917 Patienten des oertlichen Melanomregisters die Indikation fuer eine palliative Radiotherapie bei fortgeschrittenem malignen Melanom gestellt. Zu Beginn der Radiotherapie hatten elf Patienten inoperable Primaer- oder Rezidivtumoren oder wiesen postoperativ Tumorreste (R2) auf (UICC IIB); 57 Patienten hatten Lymphknoten- (n=33) oder In-transit-Metastasen (n=24) (UICC III): 53 hatten Fernmetastasen (sieben M1a; 46 M1b) (UICC IV). Von der Erstdiagnose bis zum Beginn der Strahlentherapie vergingen im Mittel 19 (median: 18; Spanne: drei bis 186) Monate. Bei 77 Patienten wurde eine konventionell fraktionierte Radiotherapie und bei 44 Patienten ein hypofraktionierte Radiotherapie mit Einzeldosen von 2 bis 6 Gy und einer mittleren Gesamtdosis von 45 (median: 48; Spanne: 20 bis 66) Gy appliziert. Ergebnisse: Eine komplette (CR) und/oder partielle Remission (CR+PR) nach drei Monaten erzielten sieben (64%) bzw. alle Patienten im Stadium UICC IIB, 25 (44%) bzw. 44 (77%) im Stadium UICC III und neun (17%) bzw. 26 (49%) im Stadium UICC IV. Bei 25 (21%) Patienten war der Tumor progredient. Patienten, die eine CR

  20. Appropriate uptake period for myocardial PET imaging with {sup 18}F-FDG after oral glucose loading; Optimaler Akquisitionszeitpunkt fuer die Herz-PET mit {sup 18}F-FDG nach oraler Glukosebelastung

    Energy Technology Data Exchange (ETDEWEB)

    Brink, I.; Hentschell, M.; Hoegerle, S.; Moser, E. [Abt. Nuklearmedizin, Radiologische, Universitaetsklinik Freiburg (Germany); Nitzsche, E.U. [Abt. Nuklearmedizin und PET, Universitaetsklink Basel (Switzerland); Mix, M.; Schindler, T. [Div. of Nuclear Medicine and Biophysics, UCLA School of Medicine, Los Angeles, CA (United States)

    2003-02-01

    Akquisitionszeitpunkts fuer die myokardiale Vitalitaetsdiagnostik mittels statischer {sup 18}F-FDG-PET bei Patienten mit und ohne Diabetes mellitus nach oraler Glukoseapplikation. Methodik: Statische PET-Aufnahmen wurden bei 27 Patienten mit koronarer Mehrgefaesserkrankung und anamnestisch dokumentiertem Myokardinfarkt nach 4-stuendiger Nahrungskarenz zu unten genannten Zeitpunkten nach Injektion von 330 {+-} 20 MBq FDG akquiriert. Die Bildbewertung erfolgte semiquantitativ nach ROI-Analyse durch Bestimmung des Aktivitaetsverhaeltnisses zwischen Myokard und Blutpool (M/B). I.) Scans 30 min, 60 min und 90 min p. i. bei zehn stoffwechselgesunden Patienten (60 g Glukose oral, 1 h vor FDG-Injektion, Insulin nach Bedarf); II.) Scans 30 min, 60 min und 90 min p. i. bei zehn Patienten mit KHK und nicht insulinpflichtigem Diabetes mellitus (20 g Glukose oral, 1 h vor FDG-Injektion, Insulintriggerung); III.) Scans 90 min p. i. bei sieben Patienten mit KHK und nicht insulinpflichtigem Diabetes mellitus mit Nuechtern-Blutzuckerkonzentration zwischen 140 und 200 mg/dl (nur Insulin, keine Glukose). Ergebnisse: I.) Der Quotient M/B erhoeht sich signifikant bei Stoffwechselgesunden mit Verlaengerung der Uptake-Zeit (30 min 1,95 {+-} 0,20; 60 min 2,96 {+-} 0,36; 90 min 3,78 {+-} 0,43). II.) Nicht insulinpflichtige Diabetiker weisen ein deutlich geringeres M/B-Verhaeltnis auf, das jedoch ebenfalls mit der Uptake-Zeit signifikant steigt (30 min 1,56 {+-} 0,10; 60 min 2,15 {+-} 0,14; 90 min 2,71 {+-} 0,19). III.) Auch bei erhoehter Nuechtern-Blutzuckerkonzentration ergab eine kombinierte Glukose/Insulingabe gegenueber alleiniger Insulinapplikation 90 min p. i. eine hoehere Bildqualitaet (M/B 2,71 {+-} 0,19 versus 2,16 {+-} 0,07). Schlussfolgerung: Die Uptake-Zeit von 90 min fuehrt gegenueber kuerzeren Intervallen bei stoffwechselgesunden Patienten und Patienten mit nicht insulinpflichtigem Diabetes mellitus zu verbesserter Bildqualitaet. (orig.)

  1. Die Rechtsstellung von Ausländern nach staatlichem Recht und Völkerrecht. Herausgegeben von Jochen Abr. Frowein und Torsten Stein. (Beiträge zum ausländischen öffentlichen Recht und Völkerrecht, Band 94) / Henn-Jüri Uibopuu

    Index Scriptorium Estoniae

    Uibopuu, Henn-Jüri, 1929-2012

    1988-01-01

    Raamatuarvustus: Die Rechtsstellung von Ausländern nach staatlichem Recht und Völkerrecht = The legal position of aliens in national and international law = Le régime juridique des étrangers en droit national et international / Max-Planck-Institut für ausländisches öffentliches Recht und Völkerrecht ; herausgegeben von Jochen A. Frowein, Torsten Stein. Berlin [etc.] : Springer, 1987

  2. Diagnosis and differential diagnosis of hydrocephalus in adults; Diagnostik und Differenzialdiagnostik des Hydrozephalus beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Langner, Soenke; Mensel, Birger; Kuehn, Jens Peter; Kirsch, Michael [Univ. Medicine Greifswald (Germany). Inst. for Diagnostic Radiology and Neuroradiology; Fleck, Steffen; Baldauf, Joerg [Univ. Medicine Greifswald (Germany). Dept. of Neurosurgery

    2017-08-15

    Hydrocephalus is caused by an imbalance of production and absorption of cerebrospinal fluid (CSF) or obstruction of its pathways, resulting in ventricular dilatation and increased intracranial pressure. Imaging plays a crucial role in the diagnosis, differential diagnosis and planning of treatment. This review article presents the different types of hydrocephalus und their typical imaging appearance, describes imaging techniques, and discusses differential diagnoses of the different forms of hydrocephalus. Imaging plays a central role in the diagnosis of hydrocephalus. While magnetic resonance (MR) imaging is the first-line imaging modality, computed tomography (CT) is often the first-line imaging test in emergency patients.

  3. Akuteffekte des polyphenolreichen unlöslichen Carobballaststoffes auf Parameter des Metabolischen Syndroms bei gesunden Erwachsenen

    OpenAIRE

    Gründel, Sindy

    2007-01-01

    Das Metabolische Syndrom stellt eine Kombination verschiedener metabolischer Anomalien in einem Individuum dar. Starkes Übergewicht gilt als maßgebende Größe in der Genese des Syndroms, welches mit einem enormen Risiko für kardiovaskuläre Erkrankungen einhergeht. Um die stark steigende Prävalenz des Metabolischen Syndroms einzudämmen, sind dringend Konzepte für die Behandlung, vor allem jedoch für die Prävention von Übergewicht erforderlich. Einen wichtigen Beitrag leisten diesbezüglich Balla...

  4. Spiral CT angiography for demonstrating cerebral aneurysms before and after treatment with titanium clips; Spiral-CT-Angiographie zur Darstellung von zerebralen Aneurysmen vor und nach Versorgung mit Titan-Clips

    Energy Technology Data Exchange (ETDEWEB)

    Becker, C.; Volkmar, C.; Weber, J.; Fink, U.; Holzknecht, N.; Reiser, M. [Institut fuer Radiologische Diagnostik, Klinikum Grosshadern, Universitaet Muenchen (Germany); Yousry, T. [Abteilung fuer Neuroradiologie, Institut fuer Radiologische Diagnostik, Klinikum Grosshadern, Universitaet Muenchen (Germany); Steiger, H.J. [Klinik fuer Neurochirurgie, Klinikum Grosshadern, Universitaet Muenchen (Germany)

    1997-11-01

    Purpose: To determine the suitability of spiral CT angiography (SCTA) in patients with intracerebral titanium aneurysm clips. Material and Method: The section parameters were optimised using a phantom. 16 patients were examined preoperatively and 18 following treatment of aneurysms with clips. Results: The resolution, sensitivity and specificity for demonstrating cerebral aneurysms measuring{>=}3 mm was 91.3% and 75% respectively. In 15 patients with intracerebral clips there were no or only minor artefacts; three examinations were of no value because of major metal artefacts. Amongst six aneurysms demonstrated angiographically, two, which measured more than 3 mm, could be shown by SCTA. Conclusion: SCTA was able to demonstrate intracerebral aneurysms measuring{>=}3 mm. Titanium clips did not usually affect image quality significantly. (orig.) [Deutsch] Ziel: Unsere Untersuchungen sollten die Eignung der Spiral-CT-Angiographie (SCTA) fuer Patienten mit intrazerebralen Titan-Aneurysma-Clips pruefen. Material und Methode: An einem Phantom wurden die Schichtparameter optimiert. 16 Patienten wurden praeopertiv und 18 nach operativer Clippung eines Aneurysmas untersucht. Ergebnisse: Die untere Nachweisgrenze, Sensitivitaet und Spezifitaet fuer den Nachweis von zerebralen Aneurysmen lag bei{>=}3 mm, 91,3% und 75%. Bei Patienten mit intrazerebralen Clips wiesen 15 Untersuchungen keine oder geringe Artefakte auf, drei Untersuchungen konnten wegen ausgepraegter Metallartefakte nicht ausgewertet werden. Von den 6 angiographisch nachweisbaren Restaneurysmen konnten zwei mittels SCTA dargestellt werden, deren Durchmesser ueber 3 mm lag. Schlussfolgerung: Mit der SCTA koennen intrazerebrale Aneurysmen und Restaneurysmen{>=}3 mm nachgewiesen werden. Titanclips beeintraechtigen dabei die Bildqualitaet meist nicht nachhaltig. (orig.)

  5. Urban Image Construction in Macau in the First Decade after the “Handover”, 1999-2008 Zur Konstruktion des Stadtbildes von Macau im ersten Jahrzehnt nach der "Übergabe" (1999-2008

    Directory of Open Access Journals (Sweden)

    Hendrik Tieben

    2009-04-01

    Full Text Available This paper describes the transformation of Macau’s urban image in the first decade after the “handover” of the Portuguese enclave to the People’s Republic of China (PRC. In the pre-handover years and the first years of the newly established Macau Special Administrative Region (MSAR, urban interventions created an image thought to assure the continuity of Macau’s Eurasian identity along with future financial stability. In 2002, with the governmental decision not to renew the local gambling monopoly, Macau’s urban image was radically transformed. The liberalization of the gambling industry after Macau’s return to the PRC was combined with the deregulation of building heights, developer-friendly land sales, a growing number of migrant workers, and the liberalization of travel restrictions for mainland visitors. These deregulations were based on decisions by the MSAR and the PRC governments, respectively, and led to the exponential growth of Macau’s GDP within only six years. This paper describes how, through these decisions, Macau’s urban image and space have been transformed. Der Beitrag beschreibt die Transformation des Stadtbildes von Macau nach der "Übergabe" der portugiesischen Enklave an die Volksrepublik China.

  6. Universal energy ratings for Germany - (Part 1): Differentiated rating distributions according to energy source and energy efficiency standard; Universelle Energiekennzahlen fuer Deutschland - Teil 1: Differenzierte Kennzahlverteilungen nach Energietraeger und waermetechnischem Sanierungsstand

    Energy Technology Data Exchange (ETDEWEB)

    Schroeder, Franz; Papert, Olaf [METRONA Waermemesser Union GmbH, Muenchen (Germany); Greller, Martin [BRUNATA Waermemesser GmbH and Co. KG, Muenchen (Germany); Hundt, Volker [BRUNATA Waermemesser Hagen GmbH and Co. KG, Hamburg (Germany); Mundry, Bernhard [BRUNATA Waermemesser-Gesellschaft Schultheiss GmbH and Co., Huerth (Germany)

    2009-12-15

    Energiekennzahlen fuer Deutschland bezeichnen eine innovative Datenbank, in der aktuell 1/4 Million Gebaeude-Energieverbrauchskennzahlen der BRUNATA-METRONA-Gruppe aus den vergangenen Jahren normiert zusammengefasst sind. Die Datenaufbereitung umfasst (1) eine rueckwirkende Revision aller meteorologischen Klimakorrekturen mithilfe neuer ortsgenauer Klimafaktoren des Deutschen Wetterdienstes, (2) eine Teil mengenbildung von 18 Kennzahlvergleichsgruppen nach drei Hauptenergie- traegern und sechs waermetechnischen Sanierungsstaenden sowie (3) eine kontinuierliche Abbildung der Kennzahlverteilungen als Funktion der Gebaeudegroesse. Die Mediane der Energiekennzahlverteilungen bewegen sich ueber alle Gebaeudegroessen und Vergleichsgruppen etwa zwischen 80 und 175 kWh.m{sup -2}.a{sup -1}. Die absoluten Unterschiede der Mediane der Energiekennzahlverteilungen machen zwischen Neubauten und Gebaeuden mit nominell waermetechnisch unsanierter Gebaeudehuelle absolut zwischen 40 und 60 kWh.m{sup -2}.a{sup -1} aus, relativ fuer alle Groessenklassen und Energietraeger generell weniger als 30 %. Beim direkten Vergleich zwischen waermetechnisch sanierten und unsanierten Gebaeuden sinkt dieser Relativanteil unter 20 % fuer gas- und oelbeheizte, auf etwa 25 % fuer fernwaermebeheizte Objekte. Andererseits betragen die statistischen Verteilungsbreiten der Kennzahlverteilungen selbst schon je {+-}{sigma} = {+-}25 bis {+-}55 kWh.m{sup -2}.a{sup -1}. Die Energiekennzahl-Mediane fuer Neubauten nach 1995 liegen fuer die Energietraeger Gas und Oel ueber 100 kWh.m{sup -2}.a{sup -1}, fuer Fernwaermeobjekte ueber 80 kWh.m{sup -2}.a{sup -1}. Ein Ansatz zur Einschaetzung moeglicher Sanierungspotentiale in absoluten Energiebetraegen sowie eine Hochrechnung des wohnflaechengewichteten und am aktuellen Klima orientierten Mittelwertes des spezifischen Energieverbrauchs fuer den nationalen Mietwohnungsbestand auf ca. 120 kWh.m{sup -2}.a{sup -1} werden vorgestellt. (Abstract Copyright [2009], Wiley Periodicals, Inc.)

  7. Aspects of vulnerable patients and informed consent in clinical trials [Aspekte schutzbedürftiger Patienten sowie der Einwilligung nach Aufklärung in klinischen Prüfungen

    Directory of Open Access Journals (Sweden)

    Hundt, Ferdinand

    2013-01-01

    Full Text Available [english] Scope: To discuss the rationale behind informed consent in clinical trials focusing on vulnerable patients from a European and German viewpoint. Methods: Scientific literature search via PubMed, Medline, Google.Results: Voluntary informed consent is the cornerstone of policies regulating clinical trials. To enroll a patient into a clinical trial without having obtained written and signed consent is to be considered as a serious issue in the conduct of a clinical trial. Development of ethical guidance for physicians started before Christ Era with the Hippocratic Oath. Main function of consent, as articulated in all guidelines developed for clinical research, is to facilitate an individual’s freedom of choice, respect autonomy, and thus to ensure welfare of the participants in clinical trials. Minors are unable to provide legally binding informed consent, this issue is addressed through a combination of parental permission and minor’s assent. Illiteracy is a critical problem that affects all corners of our earth; it has no boundaries and exists among every race and ethnicity, age group, and economic class. New strategies to improve communication with patients including the use of videotapes or animated cartoon illustrations could be taught. Finally the time with the potential participant seems to be the best way to improve understanding. Conclusion: Discovery of life saving and life enhancing new treatments requires partnership that is based on good communication and trust between patients and researchers, sponsors, ethics committees, authorities, lawyers and politicians so that vulnerable patients can benefit from the results of well controlled clinical trials. [german] Ziel: Diskussion der Aspekte der Einwilligung schutzbedürftiger Patienten nach Aufklärung zur Teilnahme an klinischen Prüfungen aus europäischem und deutschem Blick.Methoden: Wissenschaftliche Literaturrecherche via PubMed, Medline und Google. Ergebnis: Das

  8. Adjuvant simultaneous radiochemotherapy following radical hysterectomy for patients with cervical cancers in high-risk situation. Results of a pilot study; Adjuvante simultane Radiochemotherapie nach operiertem Uteruszervixkarzinom in der High-Risk-Situation. Ergebnisse einer Pilotuntersuchung

    Energy Technology Data Exchange (ETDEWEB)

    Haensgen, G.; Kuhnt, T.; Pigorsch, S.; Dunst, J. [Halle-Wittenberg Univ., Halle (Germany). Klinik und Poliklinik fuer Strahlentherapie; Strauss, H. [Klinik fuer Gynaekologie der Martin-Luther-Univ. Halle/Wittenberg (Germany)

    2002-02-01

    Background: The most important factors for prognosis of cervical cancers are age and histological criteria such as the tumor size, the involvement of lymph nodes, lympho-vascular space involvement as well as microvessel involvement and poor tumor differentiation (grading 3). Here we present the results of concomitant chemo-radiation at high-risk situation of patients with cervical cancer after surgery. Patients and Methods: The study comprised 34 patients with median age of 40 years (26-63 years) after Wertheim surgical technique for cervical cancer at the FIGO Stages IB (n = 19) and IIB (n = 15). All patients were treated between November 1995 and June 1999 by a schedule of concomitant chemoradiation. The indication for this treatment was given by the positive histological proof of lymph node metastasis, microvessel or lympho-vascular space involvement as well as a G3 grading. The chemo-therapy was given in week 1 and 5 (day 1-5 and day 29-33). The dosage of cisplatin was 20 mg/m{sup 2}/d on every day and 5-FU was given as a 120-h infusion with 600 mg/m{sup 2}/d. The external beam radiotherapy was applied to the pelvis with 1.8 Gy per fraction up to 50.4-54 Gy. In two patients the paraaortal region was irradiated too because of the involvement of these lymph nodes. Results: The median observation time was 48 months (3-68 months). 30 patients are alive (88%) in complete response. Four patients died. The mean survival was 61 {+-} 3 months. We have seen only slight acute toxicities of grade 1 and 2. Three patients suffered from a grade 3 diarrhea and three patients developed a grade 3 leukopenia. In seven patients we found a secondary lymphedema as a late toxicity. Conclusion: The concomitant chemoradiation containing cisplatin in high-risk situation for cervical cancer after surgery improves the outcome and survival in these patients. (orig.) [German] Hintergrund: Entscheidend fuer die Prognose nach operiertem Uteruszervixkarzinom sind neben dem Alter

  9. A Novel Large-scale Mentoring Program for Medical Students based on a Quantitative and Qualitative Needs Analysis [Aufbau eines innovativen Mentorenprogramms für eine große Zahl Medizinstudierender nach quantitativer und qualitativer Bedarfsanalyse

    Directory of Open Access Journals (Sweden)

    von der Borch, Philip

    2011-05-01

    Ludwig-Maximilians-Universität München (LMU und beschreiben die Einführung eines innovativen, umfassenden Mentorenprogramms.Methoden: Die Bedarfsanalyse wurde durch eine an alle Medizinstudierenden der Medizinischen Fakultät gerichtete Online-Umfrage durchgeführt (n=578 von 4.109 Studenten, Rücklauf 14,1%. Außerdem führten wir Fokusgruppen mit Medizinstudenten (n=24 und ärztlichem Personal (n=22 durch. Schließlich wurden alle Studierenden, die sich für das individuelle Mentorenprogramm interessierten, zu ihren Erwartungen befragt (n=534.Ergebnisse: 83% der Medizinstudierenden äußerten Zufriedenheit mit dem aktuellen Münchener Curriculum. Im Gegensatz dazu fühlten sich nur 36.5% der Studierenden unserer großen Fakultät ausreichend im Studium betreut, und 86% der Studierenden äußerten den Wunsch nach mehr Betreuung. Die Rolle ihres Mentors wünschten sich 55.6% "sehr" als Berater, Kontaktvermittler (36.4% und Ideenlieferant (28.1%. Die Themen, die angehende Mentees im Vorfeld "sehr" mit ihren Mentoren besprechen wollten, waren die Doktorarbeit (56.6%, das Praktische Jahr (55.8% und Auslandsaufenthalte (45.5%.Schlussfolgerungen: Wir haben anhand der Erkenntnisse unserer Bedarfsanalyse ein innovatives, zweigleisiges Konzept entworfen, das aus einem beliebig skalierbaren individuellen Mentorenprogramm für Studierende in klinischen Semestern und einem Peer Mentoring-Programm für sämtliche Medizinstudierende unserer Fakultät besteht. Ein Jahr nach der Initiierung des Programms haben über 300 Studierende im klinischen Studienabschnitt einen individuellen Mentor aus der Fakultät ausgewählt und 1.503 Studierende und Ärzte nahmen am Peer Mentoring teil.

  10. Making Migrants Responsible for Development: Cape Verdean Returnees and Northern Migration Policies Wenn Migranten für Entwicklung verantwortlich gemacht werden: Rückkehrer nach Kap Verde und vom „Norden“ geprägte Migrationspolitik

    Directory of Open Access Journals (Sweden)

    Lisa Åkesson

    2011-01-01

    Full Text Available In recent years, there has been a surge of “Northern” policy documents concerned with increasing the positive effects of international migration in countries of origin. This article contrasts some basic assumptions in policies on migration, return and development with an anthropological study of Cape Verdean returnees, and it reveals some important disparities between the returnees’ experiences and the ideas underpinning policy documents. The article analyses the role returnees’ savings and skills play in local change in Cape Verde, and in particular it looks into entrepreneurial activities. This is related to a discussion of the conditions that must be fulfilled in order to make it possible for return migrants to contribute to positive social change. In conclusion, the article shows that structural conditions have a fundamental impact on individual migrants’ abilities to support development, a perspective often left out of contemporary policies.In jüngster Zeit entstand eine Flut politischer Dokumente im “Norden”, die sich mit den positiven Effekten internationaler Migration in den Ursprungsländern der Migranten beschäftigen. Der vorliegende Beitrag kontrastiert einige grundlegende Annahmen im Bereich der Migrations-, Rückkehrer- und Entwicklungspolitik mit den Ergebnissen einer anthropologischen Studie über Rückkehrer nach Kap Verde und deckt einige gravierende Differenzen zwischen diesen Grundannahmen und den Erfahrungen der Rückkehrer auf. Die Autorin analysiert, welche Bedeutung die Ersparnisse und die Qualifikationen der Rückkehrer für den lokalen gesellschaftlichen Wandel haben und ist dabei insbesondere an unternehmerischen Aktivitäten interessiert. Darauf aufbauend diskutiert sie, unter welchen Bedingungen zurückkehrende Migranten positiv zum sozialen Wandel beitragen können. Sie kommt zu dem Schluss, dass die Möglichkeiten für einzelne Rückkehrer, die Entwicklung ihres Heimatlandes positiv zu beeinflussen

  11. Mid-term results after midcarpal arthrodesis using an iliac crest cortical chip for grade II/III SLAC/SNAC-wrists [Mittelfristige Ergebnisse nach mediokarpaler Teilarthrodese mit kortikospongiösem Beckenkammspan bei SLAC/SNAC-wrist Grad II/III

    Directory of Open Access Journals (Sweden)

    Zeplin, Philip H.

    2013-06-01

    Full Text Available [english] Purpose: The four-corner-fusion is an option for grade II/III SNAC-/SLAC-wrists. The case-control study evaluates the results of a four-corner-f with a screw-fixed iliac crest cortical chip. Methods: Ten patients with SNAC/SLAC-wrist ≥ grade II were treated. The evaluation occurred after 24 months using a standard study protocol. Results: The mean postoperative active range of motion were 46% (extension/flexion and 52% (radial/ulnar deviation of the contralateral wrist respectively. The postoperative mean grip strength was 43% of the contralateral side, and 84% compared to the preoperative values. The mean Cooney-Bussey Score was 63 and the mean DASH score was 25 (p≤0.05. Four of the patients (40% had to undergo a partial removal of the osteosynthetic material because of radiodorsal impingement. Conclusions: The four-corner fusion using an iliac crest cortical chip represents an alternative operating procedure for treatment, even though the period of immobilisation cannot be reduced. [german] Hintergrund: Die mediokarpale Teilarthrodese stellt eine anerkannte Behandlungsmethode bei karpalen Kollaps nach Skaphoidpseudarthrose (SNAC-wrist oder nach Ruptur des skapholunären Bandes (SLAC-wrist dar. Anhand der vorliegenden Fall-Kontrollstudie wurden die Ergebnisse nach mediokarpaler Teilarthrodese unter Verwendung eines kortikospongiösen Beckenkammspanes evaluiert. Material und Methoden: Zehn Patienten wurden 24 Monate nach mediokarpaler Teilarthrodese bei mit SLAC/SNAC-wrist Grad II/III mit einem kortikospongiösen Beckenkammspan nachuntersucht. Ergebnisse: Das mittlere postoperative Bewegungsausmaß des Handgelenkes betrug für Extension/Flexion 46% und für Radial-/Ulnaradduktion 52% im Vergleich zur unbehandelten Gegenseite. Die postoperative Griffstärke betrug im Mittel 43% der Gegenseite und 84% der präoperativen Werte. Der mittlere Cooney-Bussey-Score lag bei 63, der mittlere DASH-Score bei 25 (p≤0.05. Bei vier Patienten

  12. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 1; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 1: Methodischer Teil zum Erarbeiten von Stoerfallablaufszenarien

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.; Rogazewski, P.; Schindler, M. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A.; Albrecht, M.; Lambert, M.; Steinbach, J. [Technische Univ. Berlin (Germany)

    2000-07-01

    Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  13. Regional pulmonary edema caused by acute mitral insufficiency after rupture of chordae tendinae with prolaps of the posterior mitral valve; Regionales Lungenoedem bei akuter Mitralinsuffizienz nach Chordae-tendineae-Abriss mit Prolaps des posterioren Mitralsegels

    Energy Technology Data Exchange (ETDEWEB)

    Mauser, M.; Wiedemer, B.; Fleischmann, D. [Klinikum Lahr (Germany). Medizinische Klinik; Billmann, P. [Klinikum Lahr (Germany). Inst. fuer Radiologie; Ennker, J. [Herzzentrum Lahr/Baden (Germany). Abt. fuer Herzchirurgie

    2003-07-01

    An unilateral or predominantly lobar pulmonary edema is an unusual clinical or radiological finding, often misdiagnosed as one of the more common causes of focal lung disease. We report 2 cases of a regional pulmonary edema caused by the acute onset of a severe mitral insufficiency after the rupture of chordae tendinae resulting in a prolaps of the posterior mitral leaflet. In both cases the regional pulmonary edema was initially misdiagnosed as a pneumonic infiltration, which delayed the cardiological diagnostical procedures and the surgical intervention. The mechanism of the regional edema is an excentric regurgitation jet into the left atrium, which is usually directed to the orifice of the right upper lobe pulmonary vein which increases the hydrostatic vascular pressure in the corresponding lung segment. For the confirmation of the diagnosis, transesophageal echogradiographye is helpful in documenting the direction of the regurgitant flow and detecting differential gradients between the right and left pulmonary venous systems. The pulmonary infiltrations, which persisted for several weeks, dissappeared within a few days after surgical mitral-valve-reconstruction in both cases. (orig.) [German] Ein einseitiges oder ueberwiegend lobaeres Lungenoedem ist ein seltener klinischer und radiologischer Befund, der haeufig initial zur Fehldiagnose einer weitaus haeufigeren fokaleren Lungenerkrankung fuehrt. Wir berichten ueber 2 Faelle, bei denen nach Auftreten einer akuten Mitralinsuffizienz auf dem Boden eines Sehnenfadenabrisses am posterioren Mitralsegel ein regionales Lungenoedem zunaechst als pneumonisches Infiltrat fehlgedeutet wurde, was die weitere kardiologische Diagnostik und chirurgische Therapie verzoegerte. Wie in den wenigen in der Literatur beschriebenen Faellen findet sich hierbei ein exzentrischer Regurgitationsjet in den linken Vorhof, der ueblicherweise auf die Einmuendung der rechten oberen Pulmonalvene gerichtet ist und in dem dazugehoerigen

  14. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 2; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 2: Berechnungsmethoden, aktuelle Modelle und Modellgleichungen

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.; Rogazewski, P.; Schindler, M. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A.; Albrecht, M.; Lambert, M.; Steinbach, J. [Technische Univ. Berlin (Germany)

    2000-07-01

    Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  15. Sprachvermittlung und Spracherwerb in Afrika. Deutsch nach ...

    African Journals Online (AJOL)

    Teaching foreign languages in a multilingual context, such as one finds in South African schools, poses unique questions. The theory that pedagogically underpins and articulates the value of the study of foreign languages is internationally established and thus also valid in the South African context. Nevertheless, one has ...

  16. Auf der Suche nach Gotte urknall

    CERN Document Server

    heinrich, Hansjörg

    2007-01-01

    In a mega tunnel near Geneva Lake, a second big-bang will take place soon. The world elite of physics hope to answer existential questions for humanity: How was made our Universe? From where do we come? which energy holds cosmos together? (4 pages)

  17. Auf der Jagd nach der Weltformel

    CERN Multimedia

    Von Rauchhaupt, U

    2004-01-01

    Forscher träumen seit jeher davon, sämtliche physicakilschen Phänomene mit einem einzigen, fundamentalen Naturgesetz erklären zu können. Schon viele Denker sind daran gescheitert, selbst Einstein. Seit einigen Jahren gilt die Stringtheorie als vielversprechender Ansatz (6 pages)

  18. Sprachvermittlung und Spracherwerb in Afrika. Deutsch nach ...

    African Journals Online (AJOL)

    -0-49 ... Keywords: multilingualism, language-constellation, metalinguistic and linguistic awareness, socio- economic relationships ..... Noun classification and congruence in German and Zulu – a contrastive analysis. Journal for Language ...

  19. Putin nach Putin: was den Westen erwartet

    OpenAIRE

    Rahr, Alexander

    2010-01-01

    "2011 finden in Russland Parlamentswahlen, Anfang 2012 Präsidentschaftswahlen statt. Es wird immer wahrscheinlicher, dass Wladimir Putin in den Kreml zurückkehrt. Premierminister Putin und Staatspräsident Dmitrij Medwedew rivalisieren momentan gegeneinander in einer Art "Primary" um die Gunst der Bevölkerung. Im Sommer nächsten Jahres wird einer von ihnen von der Partei Einheitliches Russland zum Spitzenkandidaten gekürt werden. Putin ist Chef der Partei der Macht, und Putin und Medwedew unte...

  20. Erektile Dysfunktion - Was kommt nach Viagra?

    Directory of Open Access Journals (Sweden)

    Jungwirth A

    2001-01-01

    Full Text Available Man darf nie vergessen, daß es sich bei der erektilen Dysfunktion nicht um ein "Life-Style"-Thema, sondern um eine Erkrankung handelt, welche die Lebensqualität der Patienten deutlich verschlechtert. Die Therapie der erektilen Dysfunktion hat sich in den letzten Jahren revolutioniert und wie man sieht, ist sowohl die Forschung als auch die Pharmaindustrie bemüht, für den Patienten neue, bessere, schneller wirksame und nebenwirkungsärmere Medikamente zu entwickeln. Diese neuen Entwicklungen werden für uns Andrologen/Urologen das Armamentarium für die Therapie der erektilen Dysfunktion bereichern. Welche der nun genannten Substanzen letztendlich übrigbleiben und mit welchen Substanzen wir uns in der näheren Zukunft zu befassen haben, werden die weiteren Entwicklungen zeigen.

  1. Signifikante Verbesserungen eines klinischen Untersuchungskurses nach einfachen strukturierten Veränderungen des Lehrinhalts und der Lehrmethoden [Significant improvement of a clinical training course in physical examination after basic structural changes in the teaching content and methods

    Directory of Open Access Journals (Sweden)

    Bott-Flügel, Lorenz

    2013-05-01

    von ihnen erlernten Untersuchungstechniken führen.Methoden: In drei medizinischen Kliniken der Technischen Universität München wurden im Sommersemester 2010 die quantitativen Evaluationsergebnisse (deutsches Schulnotensystem, Noten 1-6 von insgesamt 49 Studierenden von einem Kurstag vor und einem Kurstag nach strukturierten Verbesserungsmaßnahmen des klinischen Untersuchungskurses verglichen. Zum Einsatz kamen strukturierte Instruktion der Dozenten, Handouts und über das Internet verfügbares Zusatzmaterial.Ergebnisse: Es wurden 47 Evaluationsbögen vor und 34 Evaluationsbögen nach den Verbesserungsmaßnahmen ausgefüllt. Die oben genannten Maßnahmen führten zu signifikanten Verbesserungen der Evaluationsnoten in folgenden Bereichen: Einführen ins jeweilige Kursthema (von 2,4±1,2 auf 1,7±1,0, p=0,002 und in hygienische Maßnahmen (von 3,8±1,9 auf 2,5±1,8, p=0,004, strukturiertes Vorführen der einzelnen Untersuchungsschritte (von 2,9±1,5 auf 1,8±1, p=0,001, Üben der Untersuchungsschritte (von 3,1±1,8 auf 2,2±1,4, p=0,030, strukturiertes Feedback zur Untersuchungstechnik (von 3,0±1,4 auf 2,3±1,0, p0,=0,007, Verwenden von Handouts (von 5,2±1,4 auf 1,8±1,4, p<0,001, Tipps zu weiterem Lernmaterial (von 5,0±1,4 auf 3,4±2,0, p<0,001, Lernerfahrung insgesamt (von 2,4±0,9 auf 1,9±0,8, p=0,017 und Selbsteinschätzung der Studenten bezüglich der Sicherheit bei der Durchführung einer körperlichen Untersuchung (von 3,5±1,3 auf 2,5±1,1, p<0,001.Zusammenfassung: Strukturierte Verbesserungsmaßnahmen führten zu signifikanten Verbesserungen der Evaluationsnoten eines klinischen Untersuchungskurstages in den Bereichen „Vorbereitung der Dozenten“, „Struktur des Kurses“ und „selbst eingeschätzte Sicherheit beim Durchführen einer Untersuchung“.

  2. Ľudská túžba po uznaní a fenomén otroctva v procese vývoja sebavedomia u G. W. F. Hegla (Die menschliche Sehnsucht nach Anerkennung und das Phänomen der Sklaverei in dem Prozess der Etwicklung des Selbstbewusstseins bei G.W.F. Hegel

    Directory of Open Access Journals (Sweden)

    Hedviga Marcinková

    2010-06-01

    Full Text Available Der Mensch ist nicht nur die blosse biologische Existenz, er ist eine hoehere-menschliche Existenz, die durch die Sehnsucht nach Anerkennung von anderen gekennzeichnet ist. Nach G. W. F. Hegel beteiligt sich der Mensch als Selbstbewusstsein an dem Prozess der Anerkennung. In Zussammenhang mit diesem Prozess entsteht das Phänomen der Sklaverei, das sich in der Situation der Knechtschaft widerspiegelt. Diese Situation behandelt Hegel in der Phänomenologie des Geistes in dem Kapitel Selbständigkeit und Unselbständigkeit des Selbstbewusstseins: Herrschaft und Knechtschaft. Er analysiert die Positionen des Herrn und des Knechtes und präsentiert beide Formen der Anerkennung (sowohl die an der Seite des Herrn als auch die an der Seite des Knechtes als defizit. Wie Hegel an dem Fall der Sklaverei demonstriert, die wirkliche Anerkennung muss gegenseitig sein. Nur durch gegensetige Anerkennung kann das Prozess der Emantipation des Sklaven vollendet werden. Auch in anderen und sozusagen modernen Formen der Diskriminierung lassen sich die Spuren von hegelschen Herr-Knecht Beziehung wiederfinden. Somit kann von den hegelschen Modell der gegenseitigen Anerkennung ein Modell der Emanzipation nicht nur fuer den Sklaven, sondern auch fuer alle Formen der Diskrimination abgeleitet werden.

  3. Die Bedeutung von Anerkennungserfahrungen in der Schule für die Ausprägung von Altruismus und Werten der Offenheit

    Directory of Open Access Journals (Sweden)

    Isabella Lussi

    2015-09-01

    Full Text Available Die Werteentwicklung gilt als eine bedeutende Aufgabe im Jugendalter. Die Schule stellt dabei neben der Herkunftsfamilie eine zentrale Sozialisationsinstanz dar. Unklar ist jedoch, welche schulischen Erlebnisse die Entwicklung von Werten beeinflussen. Basierend auf 20 biografisch-narrativen Interviews mit 19- bis 21-jährigen jungen Erwachsenen in der Schweiz verfolgte die hier berichtete Studie das Ziel, schulische Erlebnisse zu eruieren, die für die Entwicklung von Werten bedeutsam sind. Bei der Auswertung der Interviews wurde das narrationsanalytische Verfahren nach SCHÜTZE (1984 mit dem Kodierverfahren der Grounded-Theory-Methodologie nach STRAUSS (1998 [1994] und der qualitativen Typenbildung (KELLE & KLUGE 1999 kombiniert. Die Ergebnisse der Studie zeigen: Anerkennung (im Sinne von HONNETH 1992 stellt eine Kernkategorie in den sehr unterschiedlichen Schüler/innenbiografien dar, und sie ist eng verknüpft mit der Ausprägung individueller Werte von jungen Erwachsenen. Junge Erwachsene, die sich in der Schule geliebt, respektiert und wertgeschätzt fühlten, kombinieren Sicherheits- und Leistungswerte mit Offenheit und Toleranz. Ist die Schulzeit durch einen Mangel an Anerkennung geprägt, werden Sicherheits- und Leistungswerte priorisiert. Dies scheint darin begründet zu sein, dass Anerkennung eine Bedingung für Autonomie darstellt und für die Fähigkeit, vergangenen und aktuellen Erlebnissen Sinn zu verleihen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1503328

  4. Einmaliges studentisches standardisiertes Training der chirurgischen Händedesinfektion nach EN1500: Quantifizierung des Trainingseffektes, Nutzen der Methode und Vergleich mit klinischen Referenzgruppen [A single standardized practical training for surgical scrubbing according to EN1500: Effect Quantification, value of the standardized method and comparison with clinical reference groups

    Directory of Open Access Journals (Sweden)

    Wullenk, Katharina

    2013-05-01

    Full Text Available [english] The standardized training of practical competences in skills labs is relatively new among German Medical Faculties. The broad acceptance and outstanding evaluation results do not provide objective data on the efficiency and cost-efficiency of these trainings. This study aims on the quantification of the teaching effect of the surgical scrubbing technique EN1500 and its comparison with clinical references of OR personnel.Methods: 161 4 year medical students were randomized into intervention and control group. The intervention group received a 45 minute standardized peer-teaching training of practical competences necessary in the OR including the scrubbing according to EN1500. Fluorescence dye was mixed in the disinfectant solution. After hand disinfection, standardized fotographs and semi-automated digital processing resulted in quantification of the insufficiently covered hand area. These results were compared with the control group that received the training after the test. In order to provide information on the achieved clinical competence level, the results were compared with the two clinical reference groups.Results: The intervention group remained with 4,99% (SD 2,34 insufficiently covered hand area after the training compared to the control group 7,33% (SD 3,91, p[german] Die standardisierte Schulung klinisch-praktischer Fertigkeiten in sog. Skills Labs ist erst seit wenigen Jahren an deutschen Universitäten verbreitet. Den zumeist umfangreichen und sehr guten Evaluationsergebnissen stehen kaum Untersuchungen zur Effektquantifizierung und Kosten-Nutzen-Analyse gegenüber. In der vorliegenden Studie soll eine Methode zur digitalen Quantifizierung der Güte der chirurgischen Händedesinfektion vorgestellt werden sowie das Skills-Lab-Training der standardisierten Einreibemethode nach EN1500 auf seinen Effekt hin untersucht und mit OP-Pflegepersonal und Operateuren als klinische Referenzgruppen verglichen werden.Methode: 161

  5. Enzymes of Krebs-Henseleit Cycle in Vitis vinifera L

    Science.gov (United States)

    Roubelakis, Kalliopi A.; Kliewer, W. Mark

    1978-01-01

    Arginosuccinate (ASA) synthetase and lyase activities were detected in extracts from Vitis vinifera L. cv. Chenin blanc mature leaves and seedlings. Optimum reaction conditions for ASA synthetase were 10 millimolar l-citrulline, 7.5 millimolar l-aspartate, 3 to 4 millimolar ATP, 12 millimolar Mg2+ (pH 7.5 to 8.0), enzyme extract up to equivalent of about 200 milligrams of fresh tissue, and incubation temperature of 38 to 40 C. Optimum reaction conditions for ASA lyase were 4 millimolar ASA-K salt (pH 7.3 to 7.8), amount of extract up to equivalent of about 180 milligrams of fresh tissue, and incubation temperature of 38 to 40 C. PMID:16660513

  6. Lymphoscintigraphy for non-invasive long-term follow-up of the functional outcome in patients with autologous lymph vessel transplantation; Lymphsequenzszintigraphie fuer die nichtinvasive Langzeitbeobachtung des funktionellen Therapieerfolges nach Transplantation autologer Lymphgefaesse

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, M. [Klinikum Grosshadern, Klinik und Poliklinik fuer Nuklearmedizin, Muenchen Univ. (Germany); Baumeister, R.G.H. [Klinikum Grosshadern, Chirurgische Klinik, Abt. fuer Mikro-, Hand- und Rekonstruktionschirurgie, Muenchen Univ. (Germany); Tatsch, K. [Klinikum Grosshadern, Klinik und Poliklinik fuer Nuklearmedizin, Muenchen Univ. (Germany); Hahn, K. [Klinikum Grosshadern, Klinik und Poliklinik fuer Nuklearmedizin, Muenchen Univ. (Germany)

    1996-12-01

    Lymphoedem zu einer signifikanten Verbesserung der Lymphabflussverhaeltnisse. Die vorliegende Studie untersucht, ob die Lymphsequenzszintigraphie geeignet ist, die persistierende Funktion autologer Lymphgefaesstransplantate und damit den Erfolg dieser Operationsmethode zu dokumentieren. In die Studie gingen die Daten von 20 Patienten (17 Frauen und 3 Maenner) ein. Anlass fuer die Operation war in 4 Faellen ein primaeres, in 16 Faellen ein sekundaeres Lymphoedem. Szintigraphische Analogaufnahmen mit semiquantitativer Beurteilung des Lymphtransportes erfolgten als Ausgangsuntersuchung vor Transplantation und anschliessend ueber einen Zeitraum von sieben Jahren. Bei 17 von 20 Patienten (Transplantationssitus: Obere Extremitaet n=12, untere Extremitaet n=8) war postoperativ eine persistierende Verbesserung des Lymphtransportes im Vergleich zur praeoperativen Situation an einem signifikanten Abfall der Transportindices nachweisbar. Bei 5 Patienten gelang zusaetzlich die direkte szintigraphische Darstellung der Lymphgefaesstransplantate. In diesen Faellen konnte postoperativ ein signifikant hoeherer Abfall der Transportindices im Vergleich zu Patienten ohne szintigraphisch darstellbares Transplantat beobachtet werden. Lediglich 3 von 20 Patienten zeigten keine Besserung im Vergleich zur Ausgangssituation. Somit erwies sich die Lymphsequenzszintigraphie mit semiquantitativer Einschaetzung der Lymphabflussverhaeltnisse vor und nach autologer Lymphgefaesstransplantation als einfache, nicht invasive Untersuchungsmethode zur objektiven Beurteilung des Therapieerfolges im Langzeitverlauf. Eine szintigraphisch direkte Darstellung des autologen Lymphgefaesstransplantats scheint einen prognostisch guenstigen Faktor bezueglich der postoperativen Lymphdrainage darzustellen. (orig./MG)

  7. Risk of leukaemia following intravenous treatment with {sup 224}Ra - results of a long term follow-up study of ankylosing spondylitis patients; Leukaemierisiko nach intravenoeser {sup 224}Ra-Behandlung - Ergebnisse einer Langzeitstudie an Bechterew-Patienten

    Energy Technology Data Exchange (ETDEWEB)

    Wick, R.R. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenbiologie; Chmelevsky, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenschutz; Goessner, W. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Pathologie

    1993-12-31

    In an epidemiological study of the somatic late effects risk following incorporation of a short lived {alpha}-emitter, 1473 ankylosing spondylitis patients treated with repeated intravenous injections of {sup 224}Ra in the years 1948 - 75, have been observed in the GSF. The usual therapeutic plan consisted of a total of 10 - 12 injections of 1.036 MBq (28 {mu}Ci) of {sup 224}Ra each, given at weekly intervals; this would result in an cumulative {alpha}-dose of 0.56 - 0.67 Gy to the marrow-free skeleton of a 70-kg-man (standard man). These patients have been followed together with a control group of ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Until May 1993 (mean follow-up time 19.9 yr), 595 patients of the exposure group and 722 patients of the control group have died, causes of death have been ascertained for 578, resp. 668 patients. Among others we observed in the exposure group 10 cases of leukaemia (vs. 2.7 - 2.8 cases expected, p < 0.001) and 6 cases of leukaemia in the control group (vs. 3.3 - 3.5 exp., p = 0.14). Subclassification of the leukaemias shows a clear preference for chronic myeloid leukaemia (CML) in the exposure group (4 cases obs. vs. 0.8 cases exp., p = 0.009), whereas in the control group the observed cases of CML are within the range of expectancy. Similar observations have not been made in another group of patients, now observed by Spiess and co-workers, who have been treated at a higher dose/dose rate range. This increased incidence of leukaemias in our exposure group is in one line with results from animal experiments with bone seeking {alpha}-emitters given at low dose rates. The induction of myeloid leukaemia has been demonstrated in mice down to dose rates of only a few mGy/day also for {sup 239}Pu, an {alpha}-emitter which like {sup 224}Ra deposits preferentially on the bone surface. (orig.) [Deutsch] Im Rahmen einer epidemiologischen Studie zum somatischen Strahlenspaetschadenrisiko nach

  8. Pilot project Muehlacker - Simulated on-site sanitation by steam injection on TUBA-procedure (thermally enhanced soil vapour extraction). Final report; Modellvorhaben Muehlacker - Modellhafte In-Situ-Sanierung durch Dampfinjektion nach dem TUBA-Verfahren. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Theurer, T.; Koschitzky, H.P.; Faerber, A.

    2001-11-09

    At the University of Stuttgart, the remediation technology TUBA (thermally enhanced soil vapour extraction, Thermisch unterstuetzte Bodenluftabsaugung) has been developed. The subsurface is heated by the injection of saturated steam or a mixture of steam and air. Residual contamination of the subsurface can mostly be completely evaporated and removed in the gaseous phase. After one successful remediation of a BTEX-contamination in a pilot study at the site of the former gaswork Plauen, plans were made to test the remediation technology at the site of a former hazardous waste disposal site in Muehlacker/Enzkreis, a 'model site' of the state of Baden-Wuerttemberg, Germany. At the site, an extensive contamination of chlorinated hydrocarbons, perched in deep layers of low permeability, had happened. Low permeability of the contaminated subsurface at the site resulted in a challenge for steam injection, since high injection pressure is mandatory for an acceptable rate of steam flow. Additionally, water was held in the subsurface by capillary forces, resulting in a further reduction of permeability for the steam. The planning and implementation of the pilot-scale remediation of a selected section of the subsurface at the Muehlacker site, the experience during operation, especially as under the difficult circumstances, and the successful remediation of the target zone are presented in detail. A cost analysis, comparing to the conventional technique 'cold' soil vapour extraction (SVE), shows the TUBA remediation scheme to be economic and efficient. (orig.) [German] An der Universitaet Stuttgart wurde das Verfahren TUBA (Thermisch unterstuetzte Bodenluftabsaugung) entwickelt. Dabei wird durch die Injektion von Sattdampf oder eines Wasserdampf-Luft-Gemisches der Boden erwaermt. Im Boden vorhandener Schadstoff kann in der Regel vollstaendig verdampft und in der Gasphase abtransportiert werden. Nach einem erfolgreichen Piloteinsatz des Verfahrens am

  9. Wie hoch liegen die Personalkosten für die Durchführung einer OSCE? Eine Kostenaufstellung nach betriebswirtschaftlichen Gesichtspunkten [How high are the personnel costs for OSCE? A financial report on management aspects

    Directory of Open Access Journals (Sweden)

    Rau, Thea

    2011-02-01

    erprobt. Für die Umsetzung einer OSCE ist ein hoher Personaleinsatz erforderlich. Insbesondere für Fächer mit geringen Ressourcen ist daher eine effiziente Kostenplanung erforderlich. In der Klinik für Neurologie der Medizinischen Fakultät der Universität Ulm wurde die OSCE im Wintersemester 09/10 als Pilotprojekt eingeführt und retrospektiv eine Kostenaufstellung der Personalaufwendungen vorgenommen. Sie soll beispielhaft einen Einblick in die erforderlichen Mittel für eine OSCE mit Simulationspatienten geben. Methode: In die Berechnung des finanziellen Aufwands für die OSCE gingen ein: Anstellungsstatus des Personals mit Einsatzbereich für die OSCE, inhaltliche und zeitliche Dimension des Einsatzes. Nach der Prüfung wurde die Akzeptanz des Prüfungsformates durch ein Fokusgruppeninterview mit den Lehrenden und Studierenden untersucht.Ergebnis: Die Gesamtaufwendungen für den Personaleinsatz für die OSCE betrugen 12.468,- €. Der von der Klinik aufzubringende Anteil errechnete sich mit 9.576,- €. Studiengebühren wurden in Höhe von 2.892,-€ verwendet. Bei Umrechnung der Gesamtaufwendungen auf die Anzahl der Prüflinge errechnete sich ein Betrag in Höhe von 86,- € pro Prüfling. Sowohl die Studierenden als auch die Lehrenden bestätigten die Validität der Prüfung und sahen in der neuen Prüfung den Mehrwert in den Lerneffekten. Schlussfolgerung: Die hohe Akzeptanz der OSCE in der Neurologie bei Studierenden und Lehrenden spricht für eine Beibehaltung des Prüfungsformates. Vor dem Hintergrund des hohen finanziellen und logistischen Aufwands einer OSCE sollte jedoch im Einzelfall geprüft werden, wie langfristig eine effiziente Prüfungsdurchführung möglich ist.

  10. Local lysis with Alteplase for the treatment of acute embolic leg ischemia following the use of the Duett {sup trademark} closure device: preliminary results; Lokale Alteplase-Lyse zur Therapie der akuten embolischen Beinischaemie nach Einsatz des Duett {sup trademark} -Verschluss-Systems: vorlaeufige Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Schuermann, K.; Buecker, A.; Wingen, M.; Tacke, J.; Wein, B.; Guenther, R.W. [Klinik fuer Radiologische Diagnostik des Universitaetsklinikums der RWTH Aachen (Germany); Janssens, U. [Medizinische Klinik I (Kardiologie) des Universitaetsklinikums der RWTH Aachen (Germany)

    2004-04-01

    Purpose: To analyze retrospectively the result of the alteplase lysis therapy of embolic complications following the use of the Duett closure device. Methods and Materials: For 3.5 years, the Duett closure device was used in 1,398 angiographies to close the femoral puncture site. The Duett device consists of a balloon and a liquid procoagulant containing collagen and thrombin, which is injected into the puncture tract under endovascular balloon protection of the arterial puncture site. In 9 patients (0.64%), the procoagulant was incidentally injected into the femoral artery causing acute leg ischemia. Eight patients received local lysis therapy with alteplase via a contralateral femoral access. One patient underwent surgery. On average, 21 mg alteplase (4-35 mg) were administered within 14 h (4-21 h). The course of the lysis was followed angiographyically and clinically. All patients were inteerviewed by telephone 23 months (4-35 months) later.Results: In 3 patients, lysis was complete. In 5 patients, only little thrombotic material remained. In all patients, symptoms of ischemia resolved completely within the first hours after initiation of lysis. In 5 cases, bleeding occurred at the puncture site closed with the Duett device during lysis, including development of a false aneurysm in 2 cases. Complications led to premature termination (n=2) or interruption of the lysis (n=3). All complications were treated conservatively. Clinically, long-term sequelae were paresthesia and hypoesthesia in the lower leg and foot in 2 patients treated with lysis, and in the patient who underwent surgery. (orig.) [German] Ziel: Das Ergebnis der Alteplase-Lysetherapie von Embolien nach Einsatz des Duett-Verschluss-Systems wurde retrospektiv untersucht. Methoden: Innerhalb von 3,5 Jahren wurde nach 1398 Angiographien das Duett-System zum Verschluss der femoralen Punktionsstelle eingesetzt. Das System besteht aus einem Ballon und einem fluessigen Prokoagulans (Kollagen, Thrombin), das

  11. The influence of reduction and radiation dose on the incidence of radiation-induced pneumonitis, lung fibrosis and pericarditis after radiation of mediastinum applied in the treatment of Hodgkin`s disease; Der Einfluss der Reduktion der Bestrahlungsdosis auf die Inzidenz der radiogenen Pneumonitis, Lungenfibrose und Perikarditis nach Mediastinalbestrahlung bei der Behandlung der Lymphogranulomatose

    Energy Technology Data Exchange (ETDEWEB)

    Libera, T. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Muecke, R. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Cihal, S. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Knauerhase, H. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Ziegler, P.G. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Hamann, D. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany); Kundt, G. [Rostock Univ. (Germany). Inst. fuer Medizinische Informatik und Biometrie; Strietzel, M. [Zentrum fuer Radiologie, Klinik und Poliklinik fuer Strahlentherapie, Rostock Univ. (Germany)

    1997-06-01

    Mediastinalbestrahlung durch, 126 Patienten davon erhielten vor Bestrahlung eine Polychemotherapie (in der Mehrzahl fuenf oder mehr Zyklen). Mitte 1986 erfolgte eine Reduktion der Bestrahlungsdosis sowohl bei alleiniger Radiatio (befallene Lymphknotenstationen von 45 Gy auf 40 Gy sowie nichtbefallene Lymphknotenstationen von 40 Gy auf 36 Gy) als auch nach Polychemotherapie (befallene Lymphknotenstationen von 40 Gy auf 36 Gy sowie nichtbefallene Lymphknotenstationen von 36 Gy auf 30 Gy). Vor Dosisreduktion wurde bei 46 Patienten und nach Dosisreduktion bei 95 Patienten eine Mediastinalbestrahlung durchgefuehrt. Strahlentherapeutisch kamen 60-Kobalt-Gammastrahlung, 15-MV- und 9-MV-Roentgen-Bremsstrahlung sowie 15-MeV- und 9-MeV-Elektronenbestrahlung zur Anwendung. Diagnostische Methode war hauptsaechlich die Roentgenthoraxuebersichtsaufnahme in zwei Ebenen, in Einzelfaellen wurden thorakale Computertomographie, Elektrokardiographie und Echokardiographie genutzt. Ergebnisse: Im gesamten Untersuchungszeitraum von 1983 bis 1992 wurde nach Mediastinalbestrahlung in 31% eine Pneumonitis, in 16% eine Lungenfibrose und in 10% eine Perikarditis diagnostiziert. Nach Reduktion der Bestrahlungsdosis verringerten sich die Pneumonitisrate von 35% auf 24% (erreicht annaehrend das Signifikanzniveau von p<0,05), die Lungenfibroserate von 24% auf 12% (signifikant mit p<0,05) und die Perikarditisrate von 26% auf 2,1% (signifikant mit p<0,01). Kumulatives Gesamtueberleben und rezidivfreies Ueberleben verschlechterten sich durch die Reduktion der Bestrahlungsdosis nicht. Schlussfolgerungen: Die Reduktion der Bestrahlungsdosis bei der Behandlung der Lymphogranulomatose hat sich aufgrund der Verringerung der Nebenwirkungsraten bei vergleichbaren Therapieergebnissen als sinnvoll erwiesen. (orig./AJ)

  12. Verletzungsschwere und -lokalisationen polytraumatisierter Kinder im Vergleich zu Erwachsenen und deren Bedeutung für das Schockraummanagement

    DEFF Research Database (Denmark)

    Zwingmann, J; Schmal, H; Südkamp, N P

    2008-01-01

    room management for adults and, especially, the radiolgical diagnostic chain with CT scans should also be applied to polytraumatised children. The main reasons for this are the extremely high incidence of intracranial injuries and the high sensitivity of CT scans also for abdominal trauma and pelvic...

  13. Solar-optimized building construction. TC3: Solar-optimized new building ECOTEC 1 and 2: Construction of a new office and laboratory building in two stages, optimised according to solar, energetic and ecological aspects. Phase 1: Projecting, construction and system optimisation. Final report; Solaroptimiertes Bauen. TK 3: Solaroptimierter Neubau ECOTEC 1 und 2: Neubau eines Buero und Laborgebaeudes in zwei Bauabschnitten, optimiert nach solaren, energetischen und oekologischen Gesichtspunkten. Phase 1: Planung, Bauausfuehrung und Systemoptimierung. Schlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-07-01

    The two ECOTEC buildings are constructed on the premises of Bremen university. They are identical mirror buildings with optimised solar technology and heat pumps to reduce the dependence on external energy supply. The results achieved so far are promising. [German] Im Mittelpunkt des Vorhabens stand die Errichtung der solaroptimierten Niedrigenergie-Gebaeude ECOTEC in zwei Bauabschnitten gleichem, aber spiegelverkehrtem Grundrissen auf dem Gelaende des Technologieparks der Universitaet Bremen. Das Planungskonzept sah zur Reduktion des Fremdenergiebedarfs den optimierten Einsatz und die Kopplung von Solarenergie, Waermepumpe ueber die Gebaeudeleittechnik vor. Basis fuer alle Berechnungen und Planungen war der Niedrigenergiestandard, der durch erhoehte Waermedaemmung der Gebaeudehuelle, kontrollierte Lueftung, solartechnische Module und solararchitektonische Merkmale erreicht und sogar ueberschritten wurde. Durch den gezielten Einsatz der Gebaeudeleit- und -systemtechnik wird ein energiesparender Betrieb insbesondere der Gebaeudebeheizung, der Lueftungsanlage sowie der Beleuchtung schon in der Planungsphase vorbereitet. Zusammenfassend laesst sich feststellen, dass das entwickelte Technikkonzept nach erfolgter Abstimmung mit den Nutzerbeduerfnissen geringste Energieverbraeuche bei sehr gutem Komfort bietet. (orig.)

  14. Substancinė Dievo formos kaita kaip meninė Visybės reprezentacija (pagal Thomo Manno romaną Juozapas ir jo broliai | Substanziales Werden der Form Gottes als künstleriche Repräsentation des Ganzen (nach der Tetralogie Joseph und seine Brüder von Thomas Mann

    Directory of Open Access Journals (Sweden)

    Juldita Nagliuvienė

    2004-01-01

    Full Text Available Anhand der Polemik zwischen der Totalitätsphänomenologie von Emmanuel Lévinas und der Selbstphänomenologie von Ernst Bloch werden in diesem Artikel die Erscheinungen Gottes, mit denen sich das patriarchalische Subjekt in die Beziehung eingetreten ist, analysiert. Vor allem aktualisiert man den substanziellen Inhalt der künstlerichen Gottesform, deren Wurzeln in der primitiven archaischen Ikonographie der Babylonier und der Ägypter liegen. Das Bild Gottes verwandelt sich in der Situation der Begegnung aus der Substanz des unförmigen Steines, die pfallische Intentionen des Helden akzentuiert, in die symbiotische Form eines Menschentieres (oder Gottes-Tieres, das als Fremde Gott auf der Ebene der Erzählung funktioniert und den Numenaspekt durch die künstliche Form der animalischen Gottheit in sich trägt. Durch die Maske des Tieres strebt der göttliche Begegnungspartner, der das Werden Gottes aktualisiert, nach der Verwandlung in die Gestalt eines sterbenden und wieder auferstehenden Menschen-Gottes, der den sündigen Menschen erlösen kann. In der Tetralogie von Thomas Mann existiert diese Ebene des Nochnicht-gewordenen-Gottes als utopische Stufe der vollkommenen Beziehungen zwischen Mensch und Gott. Die Begegnung zwischen dem tierischen Gott und dem Helden geschieht im Roman in der Traumsphäre, die den Dialog zwischen dem Kunstding und dem Menschen möglich macht. Auf der Traumebene wird der Prozess der Metamorphose einer Gottheit dargestellt, aber sie erscheint als ein schon verwandeltes Wesen, das die Antropomorphie des Erlösungsprinzips aufnimmt, und dem Helden erst im bewussten Zustand begegnet.

  15. Procedure to determine the optimal main primary coolant pump parameters of the FRG-1 reactor. P.1: Development concept, optimization criteria and general logical structure of the procedure; Verfahren zur Bestimmung der optimalen Kenndaten der Hauptprimaerumwaelzpumpe nach der Kernkompaktierung des Reaktors FRG-1. T.1: Entwicklungskonzept, Optimierungskriterien und allgemeine logische Struktur des Verfahrens

    Energy Technology Data Exchange (ETDEWEB)

    Pihowicz, W. [GKSS-Forschungszentrum Geesthacht GmbH (Germany). Zentralabteilung Forschungsreaktoren

    1998-12-31

    First a development concept of the procedure was derived. Following this concept the procedure has to be derived stepwise, i.e. on subsequent logical levels. Furthermore, the report contains the results of the first two logical levels. On the first (basic) level the optimization criteria had been formulated. The general logical structure of the procedure results from the second logical level (macro level) of the evaluation process. This structure consists of four determination blocks, one identification unit and some determination elements as well as their logical interconnections in the form of decision and result units. The blocks serve for the realization of the closed and composed partial tasks of the procedure. They themselves form the complicated but not yet deviced partial structures, which again are the logical connections of the determination elements. In contrast to the blocks all determination elements are simple enough, so that their direct mathematical determination becomes possible. They serve for the solution of simple partial tasks. (orig.) [Deutsch] Zuerst wurde ein Konzept zur Entwicklung des Verfahrens erstellt. Nach dem Konzept soll das Verfahren stufenweise, auf nacheinander folgenden logischen Ebenen abgeleitet werden. Ausserdem enthaelt die Abhandlung noch die auf den zwei anfaenglichen logischen Ebenen des Entwicklungsprozesses erzielten Resultate. Auf der ersten Ebene (Grundebene) wurden die Optimierungskriterien formuliert. Die allgemeine logische Struktur des Verfahrens ergibt sich als Resultat der zweiten logischen Ebene (Makroebene) des Entwicklungsprozesses. Diese Struktur setzt sich aus vier Bestimmungsbloecken, einer Identifikationseinheit und einigen Bestimmungselementen sowie ihrer logischen Verknuepfung in Form der Entscheidungs- und Ergebniseinheiten zusammen. Die Bloecke dienen zur Realisierung der geschlossenen und zusammengesetzten Teilaufgaben des Verfahrens. Sie bilden selbst die komplizierten, jedoch noch nicht abgeleiteten

  16. Pyrrole and 2,5-heptanedione in the urine of rats and 2,5-heptanedione in the urine of man: analytical determination of excretion upon exposure to n-heptane; Pyrrole und 2,5-Heptandion im Urin der Ratte und 2,5-Heptandion im Urin des Menschen: Analytische Bestimmung der Ausscheidung nach Exposition gegn n-Heptan

    Energy Technology Data Exchange (ETDEWEB)

    Stoermer, A.G.C.

    1997-09-01

    A method for quantifying levels of the neurotoxic metabolite 2,5-heptanedione in rats and man after experimental exposure to n-heptane was developed. It consisted in determining the quantity of 2,5-heptanedione excreted in urine and the relevant excretion kinetics. Moreover, the excretion of pyrrole in the urine of rats was measured. In the urine of non-exposed rats and man, a basic excretion of 2,5-heptanedione was measured, with the rates of excretion being 0.11 and 4.5 nmol per hour, respectively. This basic excretion of 2,5-heptanedione is assumed to have an endogenous cause. The quantitive investigation of the dose dependence of the excretion of 2,5-heptanedione and pyrrole in the urine of rats and of 2,5-heptanedione in the urine of man is a prerequisite for assessing the risk posed by n-heptane with a view to peripheral neuropathies. (orig./MG) [Deutsch] Ziel dieser Arbeit war die Entwicklung einer Methode zur Quantifizierung der Belastung von Ratte und Mensch mit dem neurotoxischen Metaboliten 2,5-Heptandion nach experimentellen Expositionen gegen n-Heptan. Dazu sollte jeweils die ausgeschiedene Menge und die zugehoerige Ausscheidungskinetik von 2,5-Heptandion im Urin bestimmt werden. Darueber hinaus sollte die Ausscheidung von Pyrrolen im Urin von Ratten gemessen werden. Im Urin von nicht exponierten Ratten und Menschen wurde eine Grundausscheidung von 2,5-Heptandion gefunden, wobei die Ausscheidungsraten jeweils 0,11 bzw. 4,5 nmol/h betrugen. Fuer die Grundausscheidung von 2,5-Heptandion wird ein endogener Ursprung angenommen. Die quantitativen Untersuchungen zur Dosisabhaengigkeit der Ausscheidung im Urin von 2,5-Heptandion und Pyrrolen bei der Ratte und von 2,5-Heptandion beim Menschen sind eine Grundvoraussetzung fuer eine Abschaetzung des Risikos von n-Heptan fuer periphere Neuropathien. (orig./MG)

  17. Histologische und immunohistochemische Untersuchung am menschlichen Rhabdosphinkter

    Directory of Open Access Journals (Sweden)

    Holliger S

    2001-01-01

    Full Text Available Ziel: Es bestehen zunehmend Hinweise, daß dem Rhabdosphinkter eine zentrale Rolle im Rahmen des Kontinenzmechanismus, insbesondere nach radikaler Prostatektomie, zukommt. Gleichzeitig besteht jedoch unverändert Unklarheit über dessen genaue anatomische Ausdehnung und die Art der Muskelfasern, weshalb die vorliegende Studie, unter spezieller Berücksichtigung der Anatomie und Muskelfaserzusammensetzung, durchgeführt wurde. Material und Methode: Der Rhabdosphinkter am Autopsiepräparat von 10 Foeten (3 weiblich, 7 männlich und 5 männlichen Erwachsenen sowie 15 Prostatektomiepräparaten bei Patienten mit Prostatakarzinom wurden konventionell mittels Masson-Trichrom und Hematoxylin-Eosin sowie immunohistochemisch mittels Antikörper gegen die langsamen und schnellen quergestreiften Muskelfasern untersucht. Ergebnisse: Im menschlichen foetalen Rhabdosphinkter beträgt das Verhältnis von schnellen zu langsamen quergestreiften Muskelfasern 2 zu 1 zu Gunsten der schnellen quergestreiften Muskelfasern. Beim Erwachsenen hingegen kommt es zu einer Umkehr dieses Verhältnisses zu Gunsten der langsamen Muskelfasern in einem Verhältnis von 1 zu 4. Der männliche Rhabdosphinkter weist einen charakteristischen Hauptbestandteil im Bereich der Pars membranacea der Harnröhre mit einer dorsalen Muskellücke gegen die Denonvillier'sche Faszie hin auf. Er verdünnt sich gegen rostral und infiltriert die Prostata in 3 bis 4 klar unterscheidbaren Muskelfaserbündeln, die im Bereich des vorderen Blasenhalses enden. Diskussion: Nach der Geburt kommt es beim Menschen zur Ausbildung eines kontinenten Sphinktermechanismus unter zunehmender neuronaler Kontrolle durch das zentrale Nervensystem. Das anatomische Korrelat im unteren Harntrakt stellt die veränderte Muskelfaserzusammensetzung der quergestreiften Muskelfasern des Rhabdosphinkters dar.

  18. Primary extraparenchymal hemorrhage of the posterior cranal fossa as a premonitory symptom of atlanto-axial instability; Traumatische extraparenchymale Blutung der hinteren Schaedelgrube als Warnsymptom einer atlantoaxialen Instabilitaet

    Energy Technology Data Exchange (ETDEWEB)

    Holl, K.; Rolli, K.; Olschowski, A.; Wurm, G. [Neurochirurgische Abt., Landesnervenklinik Linz (Austria); Nussbaumer, K. [Neuroradiologische Abt., Landesnervenklinik Linz (Austria)

    2001-07-01

    The contribution discusses the cases of five patients with cranio-cerebral trauma, (four children and one adult patient), where CT examination revealed extraparenchymal hemorrhage of the posterior cranal fossa, which did not fit into their pattern of intracranial trauma and therefore gave reason to suspect a lesion of the upper cervical spine. The various types of hemorrhage found are explained, as well as the underlying cervical spine lesions, and the choice of respective therapies which proved to be successful. (orig./CB) [German] Wir berichten ueber fuenf Patienten nach Schaedel-Hirn-Trauma, deren gemeinsamer Befund in der kraniellen Computertomographie eine extraparenchymale Blutung der hinteren Schaedelgrube (HSG) ohne Zusammenhang mit dem uebrigen intrakraniellen Verletzungsmuster bzw. ohne sonstige intrakranielle Verletzung war. Es handelte sich um vier Kinder und einen Erwachsenen mit einem Durchschnittsalter von 8,8 (4-22) Jahren. Drei dieser Patienten wiesen eine epidurale Blutung am Clivus bzw. am Foramen magnum auf, bei einem Patienten handelte es sich um eine Subarachnoidalblutung um das Cerebellum, bei einem weiteren Patienten lag eine Blutung im IV. Ventrikel vor. Diese infratentoriellen Blutungen waren der erste Hinweis, dass eine Verletzung in der oberen Halswirbelsaeule (HWS) vorliegen koennte. Es wurde bei den vier Kindern als zugrundeliegende Ursache der Blutung eine ligamentaere Verletzung C1/C2 diagnostiziert, nur bei dem erwachsenen Patienten lag eine knoecherne Verletzung C1/C2 vor. Die Therapie erfolgte in den vier Faellen mit Instabilitaet chirurgisch, bei dem Patienten ohne Instabilitaet konservativ. Nach einem mittleren Nachbeobachtungszeitraum von 5,2 Jahren waren alle operierten Patienten klinisch gebessert bzw. weiterhin neurologisch unauffaellig. Es konnte bei allen Patienten eine stabile Situation C1/C2 bei guter Funktionalitaet der HWS nachgewiesen werden. (orig.)

  19. Gestations and parturitions after the Chernoby1 reactor accident. A representative evaluation for the Federal Republic of Germany and Berlin (West). Final report; Schwangerschaften und Geburten nach dem Reaktorunfall in Tschernobyl. Eine repraesentative Erhebung fuer die Bundesrepublik Deutschland und Berlin (West). Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Hoeltz, J.; Hoeltz, A.; Potthoff, P. [Infratest Gesundheitsforschung, Muenchen (Germany); Brachner, A.; Grosche, B.; Hinz, G.; Kaul, A.; Martignoni, K.; Roedler, H.D.; Schwarz, E.; Tsavachidis, C.

    1992-09-01

    In the Federal Republic of Germany (former states) a cohort study was performed to find out, if there were any untoward pregnancy outcomes (preterm births) after the Chernobyl accident. It was also investigated, whether a possibly increased incidence of premature births was correlated to fears of the pregnant women for increased radiation exposure. The study was carried out in 3 stages: In the first stage (card-file monitoring) the data of 5,548 pregnant women (date of conception between April and August 1986) were taken from their gynaecologists` card-files, and in stage 2 and 3 (questionnaire/pregnancy record monitoring) 3,946 pregnant women (date of conception between January 1987 and February 1988) additionally filled in an extensive questionnaire. The influence of the following risk factors was studied: fears, smoking, drug consumption, biomedical and socio-economic factors. Both, in the card-file monitoring and the questionnaire, there was no statistically significant difference in the rate of preterm births in areas with different radiation exposure. From women living in areas with higher radiation exposure due to the Chernobyl fallout fears related to environmental risks were mentioned more frequently. There was a statistically significant increase in premature births for the risk factors smoking, psycho-drug consumption, and for biomedical risks as documented in the pregnancy records. When comparing this study with a similar one from 1981/1982, no difference in the rate of preterm births was observed. (orig.). [Deutsch] In einer bundesweit angelegten Kohortenstudie wurde untersucht, ob nach dem Reaktorunfall in Tschernobyl in den vom Fallout hoeher betroffenen Gebieten der Bundesrepublik Deutschland (alte Laender) haeufiger unguenstige Schwangerschaftsausgaenge (Fruehgeburten) zu beobachten waren als in den uebrigen Gebieten, und ob ein eventuell erhoehtes Auftreten von Fruehgeburten mit Aengsten der Schwangeren infolge der erhoehten Strahlenexposition in

  20. Die Verlegung der Berliner Sternwarte nach Babelsberg - ein konservativer Neubeginn.

    Science.gov (United States)

    Dick, W. R.

    In 1913 the Berlin Observatory was moved from the center of the city to Babelsberg on the outskirts of Berlin, now part of Potsdam. The new observatory was considerably larger in size and with respect to its staff, and it had got a completely new equipment. At that time it was the most modern astronomical observatory in Germany and possibly even in Europe. However, the scientific results achieved afterward were not comparable to that of other institutions, especially in the USA. A main reason was the conservative concept for the observatory, drawn up by Wilhelm Foerster and his colleagues, and restricting the work to classical fields of astronomy. Foerster's successor Hermann Struve tried to follow rather strictly this concept as well as the traditions of his family of astronomers. This led to conflicts with his collaborators Eugen Goldstein, Erwin Finlay Freundlich and Paul Guthnick, who were interested rather in astrophysics than in the classical problems.

  1. Menschewiken in Stockholm vor und nach 1917 / Alexander Kan

    Index Scriptorium Estoniae

    Kan, Alexander

    2005-01-01

    Rootsi sisserännanud menševikest ja bolševikest, nende koostööst rootsi sotsiaaldemokraatidega, vene revolutsionääride tagasipöördumisest Venemaale Veebruarirevolutsiooni järel, repatrieerujaid toetanud Abikomitee tegevusest

  2. Die gezielte physiotherapeutische Nachbehandlung nach Kyphoplastie - moderne Aspekte und Konzepte

    Directory of Open Access Journals (Sweden)

    Becker S

    2004-01-01

    Full Text Available Die minimal-invasive Therapie osteoporotischer Wirbelfrakturen mit Kyphoplastie beeinflußt die Statik der Wirbelsäule, welche einen entscheidenden Einfluß auf das Gleichgewicht des Patienten hat. Eine neue operative Behandlungsmethode erfordert eine entsprechend adaptierte moderne physiotherapeutische Nachbehandlung. In diesem Artikel werden mehrere moderne Konzepte der Nachbehandlung vorgestellt, um die Wiedereingliederung der kyphoplastierten Patienten in ihr Umfeld zu erleichtern und das allgemeine Sturzrisiko zu mindern.

  3. Planen ohne Risiko: New Orleans und der Wiederaufbau nach Katrina

    Directory of Open Access Journals (Sweden)

    Anne Dölemeyer

    2011-09-01

    Full Text Available This paper deals with ‘planning’ and ‘prevention’ as two logics or rationalities of recovery planning.A brief case study on recovery planning in New Orleans in the aftermath of hurricane Katrina hasshown how, in a situation of destruction, disorientation and uncertainty, recovery planning was intendedto create the impression of a reliable framing for individual decision making on return andreconstruction. Here, planning appeared as pro-active design, with flood prevention as a necessaryand centrally assessable element. However, in the course of time and within a number of successiveplanning processes, it was precisely the attempt to model New Orleans’ future on a centralized, expertise-driven approach of reconstruction that provoked strong criticism. Consequently, dynamicsshifted from expertise-centered recovery planning to a more de-centralized mode that stressed citizenparticipation, ‘lay knowledge’ and inclusion, re-defined what New Orleans should look like in the future,as well as the role and the meaning of ‘(flood prevention’.

  4. Complications after total hip replacement. Komplikationen nach Hueftgelenksendoprothesen

    Energy Technology Data Exchange (ETDEWEB)

    Engelbrecht, E.; Siegel, A. (Endo-Klinik, Hamburg (Germany, F.R.))

    1989-10-01

    Complications seen after long-term follow-up examinations of total hip replacement should be treated immediately and completely. In the past decade a considerable increase in revisions has been noted. Radiographic assessment may be regarded as an effective means in diagnosing prosthetic complications from the surgeon's point of view. Examples are given. The difficulties in radiographic assessment of complications after cementless implanation or cemented prostheses without contrast media are mentioned. Prosthesis-related complications, such as mechanical loosening, infection with and without loosening, fatigue fractures and wear, fractures of the femur or pelvis, dislocations and surgical failures, are illustrated, as are clinical courses with gross loss of bone stock after repeated surgery and delayed revisions. Complications not related to the prosthesis such as periarticular ossification, muscle deficiencies, and nervous and vascular lesions are also explained using examples. (orig.).

  5. Quantenfische die Stringtheorie und die Suche nach Weltformel

    CERN Document Server

    Lüst, Dieter

    2011-01-01

    Lässt sich das Verhalten aller Dinge, von den kleinsten Teilchen bis zum Universum, einheitlich beschreiben? Der heißeste Kandidat für die Entwicklung einer Weltformel, die alle physikalischen Phänomene erklären kann, ist die Stringtheorie. Sollte sie sich als richtig erweisen, so würde das unser Verständnis über den Ursprung der Naturgesetze dramatisch verändern. Denn das von uns beobachtete Universum wäre dann vermutlich eine winzige Blase in einem viel größeren Gebilde, dem Multiversum. Um die Stringtheorie und die Idee des Multiversums plausibel zu machen, greift der international bekannte theoretische Physiker Dieter Lüst auf ein Modell zurück: das Leben von Fischen in einem Teich. Eines Tages gelingt es den Fischen, die kleinsten Teilchen zu identifizieren, aus denen alles im Fischteich besteht - eingeschlossen sie selbst. Sie nennen diese Urbausteine Quantenfische, da ihr Verhalten nahelegt, dass sie auch eine Art von Lebewesen sind. Doch der ersten folgt eine weitere Entdeckung der Fisch...

  6. Dänische Theologen und Deutschland nach 1945

    DEFF Research Database (Denmark)

    Schjørring, Jens Holger

    2014-01-01

    tre teologer fra det dengang unge teologiske fakultet i Århus, K.E.Løgstrup, Johannes Munck og Regin Prenter havde alle nære forbindelser til tysk teolologi. For dem alle var det afgørende at tage udfordringerne efter nazisme og besættelsesårene alvorligt og genoptage samarbejde og kritisk samtal...

  7. Nach dem Deutschstudium in Afrika wird man – was? Eine ...

    African Journals Online (AJOL)

    sie auf einen Forschungsaufenthalt in Deutschland angewiesen. Mit Hilfe von DAAD-. Stipendien erhalten jedes Jahr 3-4 Studierende diese Möglichkeit. Diejenigen, die vor Ort versuchen, ihre Maîtrise-Arbeit zu schreiben, brauchen oft mehrere Jahre für ihre. Fertigstellung. Bis Februar 2009 hatten von dem die Studie ...

  8. Nach dem Deutschstudium in Afrika wird man – was? Eine ...

    African Journals Online (AJOL)

    Three approaches towards legitimization have developed since the establishment of German Departments at African Universities, namely (i) German Studies with a view to research and epistemological science, (ii) German in intercultural studies, and (iii) career-oriented German language learning. In this paper the ...

  9. Classifying carcinogenic substances for the limitation of emission concentrations according to no. 5.2.7.1.1 of TA Luft amendment (draft); Klassierung krebserzeugender Stoffe zur Begrenzung der Massenkonzentration im Abgas nach der Nr. 5.2.7.1.1 der TA Luft-Novelle (Entwurf)

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K.; Schuhmacher-Wolz, U.; Oltmanns, J.; Hassauer, M. [FoBiG Forschungs- und Beratungsinstitut Gefahrstoffe GmbH, Freiburg im Breisgau (Germany)

    2002-07-01

    ,3-Butadien, Cadmium, Chrom, Cobalt, 1,2-Dichlorethan, Dinitrotoluole, Ethylenoxid, Asbestfasern, Kuenstliche Mineralfasern, Nickel, o-Toluidin, Propylenoxid, Prolyseprodukte, Styroloxid, Trichlorethen, Vinylchlorid, 4-Vinyl-1,2-cyclohexendiepoxid, Antimonotrioxid, kristallines Siliziumdioxid, Butanonoxim). Dazu wurde eine Methodik entwickelt, fuer die Stoffe Klassierungsvorschlaege erarbeitet und diese in Stoffberichten dokumentiert. Diese Klassierungsvorschlaege wurden in einem wissenschaftlichen Begleitkreis zur Diskussion gestellt. Zur Beurteilung der kanzerogenen Wirkstaerke bei inhalativer Exposition wurden Krebsrisikoschaetzungen (unit risk) herangezogen, die entweder in Publikationen genannt oder im Rahmen des Projektes abgeleitet wurden. Fuer alle Krebsrisikoschaetzungen erfolgte eine Beurteilung hinsichtlich ihrer qualitativen Eignung. Fuer 16 von 23 Stoffen konnte anhand von unit risk-Werten eine Reihung nach ihrer relativen Wirkstaerke vorgenommen und diese zur Zuordnungen in die Klassen der Nr. 5.2.7.1.1 der TA Luft-Novelle (Entwurf) verwendet werden. Bei 7 Stoffen lagen keine qualitativ aussagekraeftigen unit risk-Werte vor. In diesen Faellen wurde mit Methoden, die nur eine grobe Einschaetzung der krebserzeugenden Potenz im Bereich hoeherer Dosen zulassen (T25, CEL{sub min}), eine vorlaeufige Zuordnung vorgenommen. Fuer kuenstliche Mineralfasern wurde eine Betrachtung der kanzerogenen Wirkstaerke in Relation zur Wirkstaerke von Asbestfasern durchgefuehrt. (orig.)

  10. Air pollution, bronchial hyperreactivity and bronchial pulmonary disorders in children and adults. Luftverschmutzung, bronchiale Hyperreagibilitaet und Atemwegserkrankungen bei Kindern und Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Kuehr, J.; Hendel-Kramer, A.; Hader, S.; Urbanek, R. (Freiburg Univ. (Germany, F.R.). Universitaets-Kinderklinik); Karmaus, W. (Wissenschaftszentrum Berlin fuer Sozialforschung gGmbH (WZB) (Germany, F.R.)); Steinitz, H. (Staatliches Gesundheitsamt, Freiburg im Breisgau (Germany, F.R.)); Stephan, V. (National Institutes of Health, Bethesda, MD (USA))

    1989-04-01

    Bronchial hyperreactivity (BH) is a common feature of bronchial asthma. A sample of 560 school children of 2 different climate areas in the South-West of Germany was analyzed by standardized questionnaire, residential factors, passive smoking and skin prick testing (SPT) with 10 common aeoroallergens. BH was investigated by a standardized carbachol inhalation procedure (CIP) in cumulative manner. Pollutants (NO{sub 2}, particulate combustion products) in the outdoor air near the childrens residences were measured in the same winter season. The mode of heating and the ventilation manners (VM) in houses were characterized as parameters for indoor climate. In 149 children (26.6%) a BH in the CIP appeared. For multiple logistic regression analysis the best model to explain the existence of BH was fitted. In this final model the relative risk was significantly increased (odds ratio 2.39, 95%-confidence interval 1.19-4.77) by use of stoves within the dwelling burnt with gas, coal or oil. As confounding variable sensitization in SPT and passive smoking appeared significant. Outdoor air pollution and VM were not of significant relative risk. Therefore the indoor climate in residences which are heated by stoves within the rooms burnt with gas, coal or oil must be considered as a potential risk factor for bronchial hyperreactivity in childhood. (orig./MG).

  11. Influence of air pollution on the lung of adult normal, hyperreactive and asthmatic non smokers. Einfluss der Luftverschmutzung auf die Lunge von Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Matthys, H.; Eltschka, R.; Herceg, R. (Freiburg Univ. (Germany, F.R.). Abt. Pneumologie)

    1990-04-01

    The lung function data, gas (NO{sub 2}, SO{sub 2}) and concentration of dust particles of organic and mineral origine are reported from our longterm study (Freiburg, 1987-1990). Three monthly punctual lung function data measured with whole body plethysmography reflect the changes due to seasonal clima and pollution variations less reliable than continuous peak flow (PEF) measurements. On the other hand PEF-measurements over years suffer from compliance problems. Our SO{sub 2} data are to low to be measured reliable with Palmes diffusion tubes. Therefore they don't correlate with the measured lung function data. Similar results we found for the NO{sub 2} measurements which were with a mean concentration of 40 ng/m{sup 3} relativly low. Multivariant analysis of the measured meteorological and medial data, are in preparation. (orig.).

  12. Selbstgesteuertes Lernen und Modernisierungsimperative in der Erwachsenen- und Weiterbildung (Self-directed Learning and Modernization Imperatives in Adult and in Further Education).

    Science.gov (United States)

    Forneck, Hermann J.

    2002-01-01

    Supports the thesis that constructivism and self controlled learning in adult education should be considered reactions to imperatives of modernization. Recognizes that concepts of self-directed learning are accompanied by a change in the forms of organization as well as the logic and structure of action in adult education. (CAJ)

  13. Pediatric cardiology. Clinical and practical experiences with heart diseases of children, juveniles and young adults; Kinderkardiologie. Klinik und Praxis der Herzerkrankungen bei Kindern, Jugendlichen und jungen Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Nikolaus A. [Herz- und Diabeteszentrum NRW, Bad Oeynhausen (Germany). Klinik fuer angeborene Herzfehler; Kleideiter, Ulrich [Klinik fuer Kinder- und Jugendmedizin, Coesfeld (Germany)

    2011-07-01

    The book on pediatric cardiology covers the following chapters: (I) Fundamentals and diagnostics: pediatric cardiologic anamnesis, electrocardiograms, thorax X-radiography, MRT and CT of the heart, nuclear medical diagnostics, exercise tests, heart catheter examination, electrophysiological tests. (II) Leading symptoms: Cyanosis, cardiac murmur, thorax pain, palpitation, syncopes. (III) Disease pictures: congenital heart defects, acquired heart defects, cardiomyopathies, heart rhythm disturbances, heart insufficiency, arterial hypertension, pulmonary hypertension, other heart involving syndromes. (IV) Therapy: Catheter interventional therapy, post-surgical pediatric cardiac therapy, surgery involving the life-support machine, mechanical cardiovascular support systems, initial treatment of newborns with critical heart defects, heart transplantation, vaccination of children with heart diseases, medicinal therapy.

  14. 3 tesla magnetic resonance imaging in children and adults with congenital heart disease; 3-Tesla-Magnetresonanztomographie zur Untersuchung von Kindern und Erwachsenen mit angeborenen Herzfehlern

    Energy Technology Data Exchange (ETDEWEB)

    Voges, I.; Hart, C.; Kramer, H.H.; Rickers, C. [Universitaetsklinikum Schleswig-Holstein, Klinik fuer angeborene Herzfehler und Kinderkardiologie, Kiel (Germany); Jerosch-Herold, M. [Harvard Medical School, Department of Radiology, Brigham and Women' s Hospital, Boston (United States); Helle, M. [Universitaetsklinikum Schleswig-Holstein, Institut fuer Neuroradiologie, Kiel (Germany)

    2010-09-15

    Cardiovascular magnetic resonance imaging (CMR) has become a routinely used imaging modality for congenital heart disease. A CMR examination allows the assessment of thoracic anatomy, global and regional cardiac function, blood flow in the great vessels and myocardial viability and perfusion. In the clinical routine cardiovascular MRI is mostly performed at field strengths of 1.5 Tesla (T). Recently, magnetic resonance systems operating at a field strengths of 3 T became clinically available and can also be used for cardiovascular MRI. The main advantage of CMR at 3 T is the gain in the signal-to-noise ratio resulting in improved image quality and/or allowing higher acquisition speed. Several further differences compared to MRI systems with lower field strengths have to be considered for practical applications. This article describes the impact of CMR at 3 T in patients with congenital heart disease by meanings of methodical considerations and case studies. (orig.) [German] Die kardiovaskulaere Magnetresonanztomographie (MRT) hat sich zu einer etablierten bildgebenden Methode zur Untersuchung von Patienten mit angeborenen Herzfehlern entwickelt. Sie erlaubt in einer einzigen Untersuchung die exakte Beurteilung von Anatomie, globaler und regionaler Funktion, Blutfluessen sowie der myokardialen Perfusion und Vitalitaet. In der klinischen Routine erfolgen die Untersuchungen zumeist bei einer Feldstaerke von 1,5 Tesla (T), mittlerweile gibt es jedoch Geraete und Bildgebungstechniken, die die kardiovaskulaere MRT auch bei 3 T ermoeglichen. Der wesentliche Vorteil der MRT bei 3 T ist das hoehere Signal-zu-Rausch-Verhaeltnis, das sowohl zu einer Verbesserung der Bildqualitaet als auch zu einer Verkuerzung der Untersuchungszeit genutzt werden kann. Darueber hinaus bestehen verschiedene andere Unterschiede gegenueber Systemen mit niedriger Feldstaerke, die im praktischen Einsatz beachtet werden muessen. Dieser Artikel beschreibt die Erfahrungen der 3-T-MRT fuer die Untersuchung von Patienten mit angeborenen Herzfehlern anhand methodischer Betrachtungen und Beispiele. (orig.)

  15. Enzymes of Krebs-Henseleit Cycle in Vitis vinifera L: II. Arginosuccinate Synthetase and Lyase.

    Science.gov (United States)

    Roubelakis, K A; Kliewer, W M

    1978-09-01

    Arginosuccinate (ASA) synthetase and lyase activities were detected in extracts from Vitis vinifera L. cv. Chenin blanc mature leaves and seedlings. Optimum reaction conditions for ASA synthetase were 10 millimolar l-citrulline, 7.5 millimolar l-aspartate, 3 to 4 millimolar ATP, 12 millimolar Mg(2+) (pH 7.5 to 8.0), enzyme extract up to equivalent of about 200 milligrams of fresh tissue, and incubation temperature of 38 to 40 C. Optimum reaction conditions for ASA lyase were 4 millimolar ASA-K salt (pH 7.3 to 7.8), amount of extract up to equivalent of about 180 milligrams of fresh tissue, and incubation temperature of 38 to 40 C.

  16. Adipocyte protein modification by Krebs cycle intermediates and fumarate ester-derived succination.

    Science.gov (United States)

    Manuel, Allison M; Frizzell, Norma

    2013-11-01

    Protein succination, the non-enzymatic modification of cysteine residues by fumarate, is distinguishable from succinylation, an enzymatic reaction forming an amide bond between lysine residues and succinyl-CoA. Treatment of adipocytes with 30 mM glucose significantly increases protein succination with only a small change in succinylation. Protein succination may be significantly increased intracellularly after treatment with fumaric acid esters, however, the ester must be removed by saponification to permit 2SC-antibody detection of the fumarate adduct.

  17. Metabolic network capacity of Escherichia coli for Krebs cycle-dependent proline hydroxylation.

    Science.gov (United States)

    Theodosiou, Eleni; Frick, Oliver; Bühler, Bruno; Schmid, Andreas

    2015-07-29

    Understanding the metabolism of the microbial host is essential for the development and optimization of whole-cell based biocatalytic processes, as it dictates production efficiency. This is especially true for redox biocatalysis where metabolically active cells are employed because of the cofactor/cosubstrate regenerative capacity endogenous in the host. Recombinant Escherichia coli was used for overproducing proline-4-hydroxylase (P4H), a dioxygenase catalyzing the hydroxylation of free L-proline into trans-4-hydroxy-L-proline with a-ketoglutarate (a-KG) as cosubstrate. In this whole-cell biocatalyst, central carbon metabolism provides the required cosubstrate a-KG, coupling P4H biocatalytic performance directly to carbon metabolism and metabolic activity. By applying both experimental and computational biology tools, such as metabolic engineering and (13)C-metabolic flux analysis ((13)C-MFA), we investigated and quantitatively described the physiological, metabolic, and bioenergetic response of the whole-cell biocatalyst to the targeted bioconversion and identified possible metabolic bottlenecks for further rational pathway engineering. A proline degradation-deficient E. coli strain was constructed by deleting the putA gene encoding proline dehydrogenase. Whole-cell biotransformations with this mutant strain led not only to quantitative proline hydroxylation but also to a doubling of the specific trans-4-L-hydroxyproline (hyp) formation rate, compared to the wild type. Analysis of carbon flux through central metabolism of the mutant strain revealed that the increased a-KG demand for P4H activity did not enhance the a-KG generating flux, indicating a tightly regulated TCA cycle operation under the conditions studied. In the wild type strain, P4H synthesis and catalysis caused a reduction in biomass yield. Interestingly, the ΔputA strain additionally compensated the associated ATP and NADH loss by reducing maintenance energy demands at comparably low glucose uptake rates, instead of increasing the TCA activity. The putA knockout in recombinant E. coli BL21(DE3)(pLysS) was found to be promising for productive P4H catalysis not only in terms of biotransformation yield, but also regarding the rates for biotransformation and proline uptake and the yield of hyp on the energy source. The results indicate that, upon a putA knockout, the coupling of the TCA-cycle to proline hydroxylation via the cosubstrate a-KG becomes a key factor constraining and a target to further improve the efficiency of a-KG-dependent biotransformations.

  18. Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle.

    Science.gov (United States)

    Hartong, Dyonne T; Dange, Mayura; McGee, Terri L; Berson, Eliot L; Dryja, Thaddeus P; Colman, Roberta F

    2008-10-01

    Here we describe two families with retinitis pigmentosa, a hereditary neurodegeneration of rod and cone photoreceptors in the retina. Affected family members were homozygous for loss-of-function mutations in IDH3B, encoding the beta-subunit of NAD-specific isocitrate dehydrogenase (NAD-IDH, or IDH3), which is believed to catalyze the oxidation of isocitrate to alpha-ketoglutarate in the citric acid cycle. Cells from affected individuals had a substantial reduction of NAD-IDH activity, with about a 300-fold increase in the K(m) for NAD. NADP-specific isocitrate dehydrogenase (NADP-IDH, or IDH2), an enzyme that catalyzes the same reaction, was normal in affected individuals, and they had no health problems associated with the enzyme deficiency except for retinitis pigmentosa. These findings support the hypothesis that mitochondrial NADP-IDH, rather than NAD-IDH, serves as the main catalyst for this reaction in the citric acid cycle outside the retina, and that the retina has a particular requirement for NAD-IDH.

  19. Delayed effects of carcinoma in childhood or adolescence; Spaetfolgen von Krebs im Kindes- und Jugendalter

    Energy Technology Data Exchange (ETDEWEB)

    Scholz-Kreisel, Peter; Blettner, Maria [Universitaetsmedizin der Mainz Univ. (Germany). Inst. fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI)

    2016-08-01

    Due to advances in diagnostics and therapy the survival rate and survival time of juvenile oncologic patients have increased during the last years. About 80% of these patients survive 15 years after diagnosis, dependent on localization, status and some other factors. With increasing survival probability the many questions concerning delayed effects of disease and therapy arise. Especially cardiac and vascular side effects seem to be predominant. The PanCare network (Pan-European network for care of survivors after childhood and adolescent cancer) has evoked several research projects.

  20. Cognitive Processes (Probably Stimulated By Using Digital Game "Dynamic Metabolic Diagram Virtual Krebs´ Cycle"

    Directory of Open Access Journals (Sweden)

    A. M. P Azevedo

    2006-07-01

    Full Text Available This work describes some of the possible cognitive operations related to the use of an educational game type activity, which  is  part  of  the  software  e-metabolismo,  developed  to  improve  biochemical  learning.  This  interactive  activity, called  DMDV   – Dynamic  Metabolic  Diagram,  allows  participants  to  drag-and-drop  components  of  the  sequence  of chemical  reactions,  which describe  the  metabolic  route  under study.  It  also offers  to the students  quizzes  and texts about  the  subject.  The  suggestion  of  cognitive  processes  possibly  triggered  by  the  software,  which  must  improve effective learning, was based on Jean Piaget’s genetic epistemological ideas to explain the cognitive activity. One of these  processes  is  the  mere  act  of  playing  the  game,  which  Piaget  relates  to  humans  needs  of  learning  rules  of socialization.  It  also  can  be  seen  as  a  first  step  in  cognition  process,  the  so  called  adaptation  function  that  include assimilation and accommodation, interactive processes between intelligent activities and elements from the reality, to became part of the individual´s mental structures. Another example: drag and drop substracts and enzymes pieces in a  virtual  board,  each  one  corresponding  to  an  specific  place  in  a  metabolic  route.  This  operation  can  be  related  to motivation,  an  affective  element  proposed  by  Piaget  to  stimulate  curiosity  and  improve  construction  of  knowledge structures.  Besides  this  issue,  the  act  of  choosing  pieces  is  assumed  to  inform  the  student  previous  knowledge (previous  cognitive  structures,  which,  according  to  Piaget,  must  be  misbalanced  (equilibration  of  new  structures  is supposed to be part of the dynamic process of organization of new knowledge. DMDV was tested with a group of 24 students  (2003  and  another  group  of  36  students  in  2004,  of  a  Biochemistry  Course  regularly  registered  at FFFMCPA´s medicine  faculty.  The  evaluation  of the student’s apprenticeship  was  made  by a  conventional  test  and three Conceptual Maps constructed by each student, (a before playing the game, (b immediately after, and (c three months after the use of the game.

  1. Trendanalysen zur Inzidenz und Mortalität an Krebs in Deutschland seit 1970

    Directory of Open Access Journals (Sweden)

    Haberland, Jörg

    2015-06-01

    Full Text Available The present paper continues a work that has recently begun to estimate long-term incidence rates for Germany starting from 1970 up until 2010 (Haberland et al. 2014. National incidence is estimated by multiplying modeled national mortality with modeled incidence to mortality ratios obtained from regional German cancer registries. To achieve a greater stability in the results the included indicators are previously estimated (smoothed using joinpoint models. Regarding the analyzed cancer sites, breast cancer incidence rates in women and prostate cancer incidence rates in men showed highest increase since 1970. These developments are accompanied by a decline in the corresponding mortality rates since the 1990s. The estimated incidence rates of colorectal cancer in both sexes increased since 1970 for more than 20 years with a higher level in men. However, since the 1990s the rates have stagnated and even declined in the last decade. Again, the standardized mortality rates are declining since the mid-1990s. The estimated lung cancer incidence and mortality rates run mainly parallel in both sexes. However, in men the standardized rates only increase in the 1970s and have declined significantly since the 1990s. In contrast, in women the incidence and mortality rates rise permanently for the whole observation period, at a lower level compared to men.

  2. Increasing Conceptual Understanding of Glycolysis & the Krebs Cycle Using Role-Play

    Science.gov (United States)

    Ross, Pauline M.; Tronson, Deidre A.; Ritchie, Raymond J.

    2008-01-01

    Cellular respiration and metabolism are topics that are reportedly poorly understood by students and judged to be difficult by many teachers. Although these topics may not be required learning areas in some high school biology curricula, a grasp of fundamental concepts of cellular metabolic processes is advantageous for students undertaking (or…

  3. Der Unterricht zur Arzt-Patientin-Beziehung (APB im Fach Medizinische Soziologie an den medizinischen Fakultäten der Bundesrepublik Deutschland nach Änderung der Approbationsordnung für ��rzte [Teaching the doctor-patient relationship in medical sociology within German medical faculties following revisions to licensing regulations for physicians

    Directory of Open Access Journals (Sweden)

    Kiessling, Claudia

    2008-11-01

    well as to make it more multifaceted. [german] Hintergrund: Die 2002 eingeführte neue Ärztliche Approbationsordnung (ÄAppO löste in der Fachgesellschaft Deutsche Gesellschaft für Medizinische Soziologie e.V. (DGMS eine vielschichtige Diskussion aus. Um den Prozess der curricularen Verständigung zu forcieren, wurde von der AG Lehre der DGMS eine Befragung zum Thema Arzt-Patientin-Beziehung im medizinsoziologischen Unterricht durchgeführt. Methode: Die Befragung fand im Frühjahr 2005 per E-Mail statt. Instrument war ein standardisierter Fragebogen mit insgesamt dreißig Lernzielen, welche nach fünf Kriterien beurteilt werden sollten. Insgesamt 13 ExpertInnen aus Instituten der Medizinischen Soziologie an elf Medizinischen Fakultäten antworteten auf die Befragung. Die Daten wurden EDV-gestützt erfasst. In Anlehnung an die für Delphiverfahren empfohlenen Methoden wurden arithmetische Mittel und Streuungsmaße berechnet. Ergebnisse: Von den insgesamt dreißig Lernzielen wurden zwei von der Majorität der Befragten negativ beurteilt. Zwanzig weitere zeigten Beurteilungsvarianzen. Acht Lernziele, wie die soziale Rahmung der Arzt-Patientin-Beziehung, die elaborierte Sprache oder auch die Asymmetrie der Arzt-Patientin-Beziehung, wurden kollektiv positiv eingeschätzt. Bei den Lernzielen mit Beurteilungsvarianzen werden Widersprüche sichtbar. Bei einigen Lernzielen, wie etwa der Erhebung einer Sozialanamnese, klaffen erkannte Relevanz und praktische Umsetzung auseinander. Schlussfolgerungen: Die Ergebnisse bezüglich der gegenwärtigen Lehrpraxis zum Thema Arzt-Patientin-Beziehung an elf Medizinischen Fakultäten geben Orientierungen für weiterführende Diskussionen in der Medizinischen Soziologie. Zum einen führen die Antwortquote und die Diskussionspraxis der letzten Jahre zu der Schlussfolgerung, dass die Diskussion in der Fachgesellschaft über den Kreis der Fachvertreter resp. der langjährig in der Lehre Tätigen hinaus geführt werden sollte. Zum anderen

  4. Buchbesprechungen

    OpenAIRE

    1998-01-01

    Reckert, W. (1996): Väterlichkeit und pädagogische Profession am Beispiel der Heimerziehung. Frankfurt a.M.. Hartmann, K. (1996): Lebenswege nach Heimerziehung. Biographien sozialer Retardierung. Freiburg. Durrant, M. (1996): Auf die Stärken kannst du bauen. Lösungsorientierte Arbeit in Heimen und anderen stationären Settings. Dortmund. Schroeder, J./Hiller-Ketterer, I./Häcker, W./Klemm, M./Böpple, E. (1996): "Liebe Klasse, ich habe Krebs!" Pädagogische Begleitung lebe...

  5. Nuclear catastrophes and their consequences. 30 years after Chernobyl, 5 years after Fukushima; Nukleare Katastrophen und ihre Folgen. 30 Jahre nach Tschernobyl, 5 Jahre nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Liebert, Wolfgang; Gepp, Christian; Reinberger, David (eds.)

    2016-07-01

    The book on nuclear catastrophes covers the following issues: A historical oversight on nuclear power; two catastrophic reactor accidents: Chernobyl and Fukushima; presentation of important experiences on the radiological consequences of the severe accidents; regulatory reactions in Europe as a consequence of Fukushima; beyond Chernobyl and Fukushima: fundamental problems with nuclear energy.

  6. MDCT after balloon kyphoplasty: analysis of vertebral body architecture one year after treatment of osteoporotic fractures; MDCT nach Ballonkyphoplastie: Analyse der Wirbelkoerperarchitektur 1 Jahr nach Behandlung osteoporotischer Sinterungsfrakturen

    Energy Technology Data Exchange (ETDEWEB)

    Roehrl, B.; Dueber, C. [Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinik Mainz (Germany); Sadick, M. [Inst. fuer Radiologie, Universitaetsklinikum Mannheim (Germany); Brocker, K.; Voggenreiter, G.; Obertacke, U. [Zentrum fuer Orthopaedie und Traumatologie, Universitaetsklinikum Mannheim (Germany); Brade, J. [Inst. fuer Medizinische Statistik und Biometrie, Universitaetsklinikum Mannheim (Germany)

    2006-08-15

    Purpose: to evaluate the value of MDCT in the monitoring of vertebral body architecture after balloon kyphoplasty and observe morphological changes of the vertebral body. Material and methods: during a period of 26 months, 66 osteoporotic fractures of the vertebral bodies were treated with percutanous balloon kyphoplasty. The height of the vertebral body, width of spinal space, sagittal indices, kyphosis und COBB angle, and cement leakage were evaluated by computed tomography before and after treatment and in a long-term follow up. Statistical analysis was performed by calculating quantitative constant parameters of descriptive key data. In addition, parametric and distribution-free procedures were performed for all questions. Results: after kyphoplasty, the treated vertebral bodies showed a significant gain in the height of the leading edge (0.15 cm; p < 0.0001) and in the central part of the vertebral body (0.17 cm; p < 0.0001). The height of the trailing edge did not change significantly. A corresponding gain in the sagittal index was found. The index remained stable during follow-up. Treated vertebral bodies as well as untreated references showed a comparable loss of height over the period of one year. The shape of the vertebral bodies remained stable. In comparison to these findings, treated vertebral bodies showed a reduced loss of height. A significant change in kyphosis und the COBB angle was noted. In total, pallacos leakage was detected in 71% of cases. Conclusion: MDCT is an accurate method for evaluating vertebral body architecture after treatment with balloon kyphoplasty. (orig.)

  7. Inflammatory diseases of the orbit; Entzuendungen der Orbita

    Energy Technology Data Exchange (ETDEWEB)

    Zimmer, A.; Reith, W. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg (Germany)

    2008-12-15

    Inflammatory conditions belong to the most important diseases of the orbit. Children and adolescents are mostly affected and the most common cause is secondary pathogen invasion from acute sinusitis. However in adults most cases involve idiopathic orbital inflammation, previously termed pseudotumor orbitae. Clinical presentation may include painful exophthalmus, skin redness and warming, chemosis and disturbed eye motility. The challenge for imaging investigations, mainly a combination of CT scanning and MRI, is to distinguish inflammatory from malignant conditions, to define the extent of lesions and to document possible complications, such as cavernous sinus thrombosis, meningoencephalitis or cerebral abscesses. Serious potential consequences of orbital infections, including loss of vision or death, are still a risk factor and must be averted by avoidance of delays in diagnosis and appropriate clinical management. (orig.) [German] Entzuendliche Veraenderungen zaehlen zu den wichtigen Erkrankungen der Orbita. Meist sind Kinder und Jugendliche betroffen, wobei eine fortgeleitete Infektion der Nasennebenhoehlen die haeufigste Ursache darstellt. Bei Erwachsenen handelt es sich in den meisten Faellen um eine idiopathische Orbitaentzuendung - frueher unter dem Begriff Pseudotumor orbitae zusammengefasst. Zu den Leitsymptomen zaehlen schmerzhafter Exophthalmus, Ueberwaermung und Roetung der Haut, Chemosis sowie eine Bewegungseinschraenkung des Bulbus. Die Rolle bildgebender Verfahren - hier ergaenzen sich Computer- und Magnetresonanztomographie - besteht in der Differenzierung inflammatorischer und tumoroeser Prozesse und insbesondere in der Darstellung der Laesionsausdehnung sowie dem Nachweis von Komplikationen, wie einer Sinus-cavernosus-Thrombose, einer Meningoenzephalitis oder zerebralen Abszessen. Auch heute noch koennen Infektionen der Orbita schwerwiegende Folgen wie komplette Erblindung oder Tod nach sich ziehen. (orig.)

  8. Rehabilitation of deaf persons with cochlear implants; Rehabilitation Hoergeschaedigter mit Cochlearimplantaten

    Energy Technology Data Exchange (ETDEWEB)

    Gstoettner, W.; Hamzavi, J. [Universitaetsklinik fuer Hals-Nasen-Ohrenheilkunde, Wien (Austria); Czerny, C. [Universitaetsklinik fuer Radiologie, Wien (Austria)

    1997-12-01

    In the last decade, the rehabilitation of postlingually deaf adults and prelingually deaf children with cochlear implants has been established as a treatment of deafness. The technological development of the implant devices and improvement of the surgical technique have led to a considerable increase of hearing performance during the last years. The postlingually deaf adults are able to use the telephone and may be integrated in their original job. Prelingually deaf children can even visit normal schools after cochlear implantation and hearing rehabilitation training. In order to preoperatively establish the state of the cochlear, radiological diagnosis of the temporal bone is necessary. High resolution computerized tomography imaging of the temporal bone with coronar and axial 1 mm slices and MRI with thin slice technique (three dimensional, T2 weighted turbo-spinecho sequence with 0.7 mm slices) have proved to be valuable according to our experience. Furthermore a postoperative synoptical X-ray, in a modified Chausse III projection, offers good information about the position of the implant and insertion of the stimulating electrode into the cochlea. (orig.) [Deutsch] In der letzten Dekade hat sich der operative Einsatz von Cochlearimplantaten fuer die Rehabilitation taubgeborener Kinder und ertaubter Erwachsenen als erfolgreiche Therapie etabliert. Durch technische Weiterentwicklung der Implantatsysteme und Verbesserung der Operationstechnik konnten in den letzten Jahren die Hoerleistungen der Patienten deutlich verbessert werden. Postlingual ertaubte Erwachsene koennen nun oftmals wieder ins Berufsleben eingegliedert werden und praelingual ertaubte Kinder koennen regulaere Schulen besuchen. Im Rahmen der Voruntersuchung fuer die Cochlearimplantation ist die radiologische Felsenbeindiagnostik von besonderer Bedeutung. Hochaufloesendes CT des Felsenbeins in koronaren und axialen Ebenen mit 1 mm Schichtdicke und MRT in Duennschichttechnik (dreidimensionale, T2

  9. Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency

    NARCIS (Netherlands)

    Richter, S; Peitzsch, M.; Rapizzi, E.; Lenders, J.W.M.; Qin, N.; Cubas, A.A. de; Schiavi, F.; Rao, J.U.; Beuschlein, F.; Quinkler, M.; Timmers, H.J.L.M.; Opocher, G.; Mannelli, M.; Pacak, K.; Robledo, M.; Eisenhofer, G.

    2014-01-01

    CONTEXT: Mutations of succinate dehydrogenase A/B/C/D genes (SDHx) increase susceptibility to development of pheochromocytomas and paragangliomas (PPGLs), with particularly high rates of malignancy associated with SDHB mutations. OBJECTIVE: We assessed whether altered succinate dehydrogenase

  10. Zwischen Methodologie und Ideologie: Slowenische Kunsthistoriker der Wiener Schule nach 1945

    Directory of Open Access Journals (Sweden)

    Murovec, Barbara

    2015-02-01

    Full Text Available The institutionalisation of Slovenian art history began in 1913, when France Stele (1886-1972, a student of Max Dvořak (1874-1921, was appointed the conservator of the province of Carniola. It became fully established in 1919, when, after the dissolution of the Austro-Hungarian Monarchy, the University of Ljubljana was founded. The paper analyses the activities of three art historians, in addition to France Stele also Izidor Cankar (1886-1958 and Vojeslav Mole (1886-1973, who shaped Slovenian art history between the two world wars. After the end of World War II, all aspects of life were completely subordinated to the Soviet system of the one-party communist state. Ideological suitability was the only standard of acceptability, also at the university. In the immediate post-war period, the older generation of art historians, who were educated in the Western European tradition, mostly in Vienna, were placed in a completely new ideological-political context, which has highly influenced the development and methodology of the discipline until the present day.

  11. Direkt- und Spätsaat von Silomais nach Wintererbsenvorfrucht – Erfahrungen aus Forschung und Praxis

    OpenAIRE

    Graß, Rüdiger; Scheffer, Konrad

    2003-01-01

    Herkömmliche Maisanbausysteme führen häufig zu vielfachen Anbauproblemen und umweltgefährdungen: Nitratauswaschung, Bodenerosion und ein hoher Aufwand für die Unkrautregulierung. Aufgrund dieser Probleme ist der Maisanbau im Ökologischen Landbau nicht stark verbreitet. Zugleich besteht dort ein großer Bedarf an einem energiereichen Grundfutter, so dass der Mais gut in den Ökologischen Landbau passen würde. Viele Strategien zur Lösung dieser Probleme führen oft zu neuen Problemen, sind häufig ...

  12. Randschicht- und durchgreifendes Härten von 42CrMo4 nach CVD-Beschichtung

    DEFF Research Database (Denmark)

    Pantleon, Karen; Kessler, Olaf; Hoffmann, Franz

    1999-01-01

    The properties of hard coatings deposited using CVD-processes are usually excellent. However, high deposition temperatures may negativelly influence the properties of the steel substrates, especially in the case of low alloyed steels. Therefore, a subsequent heat treatment is necessary to restore...... the properties of steel substrates ready for operation. Bulk hardening and induction surface hardening as two different post-deposition heat treatments are applied on TiN-coated 42CrMo4 (AISI 4140) substrates. The results show great advantages of induction surface hardening because only low distortion appear...... and the properties of the steel substrates are improved without loosing good coating properties. Thereby, the properties of the steel substrates can be influenced by the parameters of induction heating in a wide range....

  13. Bildung in der Dritten Welt. Tendenzen und Probleme nach einem Vierteljahrhundert expansiver Bildungspolitik

    Science.gov (United States)

    von Recum, Hasso

    1983-03-01

    Educational expansion in the Third World has very often produced disappointing results. In contrast to neo-Marxist dependency theory, the causes for this are to a large extent of an indigenous nature and not primarily determined from outside. Educational systems in developing nations have frequently fallen prey to group self-interest among the ruling élite. This, and over-valuing the benefits of education, has paralyzed educational together with overall development and brought about distortions in the systems of production and employment. Educational reform alone will not suffice to alter the situation for the better. Considerable changes in the prevailing socio-economic and political conditions are also needed.

  14. Imaging techniques for diagnosis after surgery for degenerative disc disease. Bildgebende Diagnostik nach spinaler Diskushernienoperation

    Energy Technology Data Exchange (ETDEWEB)

    Trattnig, S. (Abt. fuer Osteologie, MR-Inst., Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria)); Kramer, J. (Abt. fuer Osteologie, MR-Inst., Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria)); Muehlbauer, M. (Neurochirurgische Univ.-Klinik, Vienna (Austria)); Kainberger, F. (Abt. fuer Osteologie, MR-Inst., Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria)); Imhof, H. (Abt. fuer Osteologie, MR-Inst., Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria))

    1993-10-01

    The magnetic resonance imaging findings recorded in patients after surgery for degenerative disc disease in the lumbar and cervical spine are discussed in comparison with conventional radiographs and computed tomography findings. In the lumbar spine normal postoperative findings in the immediate postoperative period can be demonstrated by MR imaging. Contrast-enhanced MR imaging can differentiate disc herniation from postoperative scar formation with a greater degree of confidence than other imaging modalities. MR imaging improves differentiation between other causes of failed back syndrome such as postoperative hematoma and infection, lateral spinal stenosis and arachnoiditis. In the cervical spine types of operative approaches, the appearance of bony stenosis and disc herniations by MR imaging are discussed. Computer tomography still has a role in the assessment of osseous complications such as central or foraminal stenosis. (orig.)

  15. Heidegger und der Nationalsozialismus oder die Frage nach dem philosophischen Empirismus

    NARCIS (Netherlands)

    Blok, V.

    2010-01-01

    This contribution discusses the philosophical meaning of Martin Heidegger’s Rectoral address. Firstly, Heidegger’s philosophical basic experience (Grunderfahrung) is sketched as providing the background of his Rectoral address: the being-historical concept of beginning (Anfang). Next, the

  16. Die Verbreitung von Power-Sharing: Bedingungen für eine friedliche Entwicklung nach Wahlen

    OpenAIRE

    Anna K. Jarstad

    2010-01-01

    Why are some elections followed by armed conflict, while others are not? This article begins to explore this question by mapping the prevalence of power-sharing agreements and patterns of post-election peace in states shattered by civil war. While democracy builds on the notion of free political competition and uncertain electoral outcomes, power-sharing reduces the uncertainty by ensuring political power for certain groups. Nevertheless, new data presented in this article – the Post-Accord E...

  17. The work of Leslie Valiant: alle die Strassen führen nach Strassen

    Directory of Open Access Journals (Sweden)

    J. Andrés Montoya

    2014-12-01

    Full Text Available . This year Leslie VALIANT becomes sixty five years old; we celebrate his fest with this work in which we analyze some of his major achievements. We focus our attention on those of his works for which a strong influence of Volker Strassen can be easily detected. Strassen’s work has had a strong and lasting influence on Valiant. It does not means, as the title could suggest, that the manyfaced, relevant and complex work of Leslie Valiant can be understood as a corollary to Strassen. Resumen. Este año Leslie VALIANT cumple 65 años y nosotros queremos celebrar este importante aniversario con este trabajo en el que se analiza su obra. Centramos nuestra atención en aquellos de sus trabajos en los que una clara influencia de Volker STRASSEN puede ser detectada. Es patente la influencia de Strassen en la obra de Valiant, pero esto no quiere decir que el trabajo de Valiant, complejo y multifacético, sea un simple corolario a la obra del primero.

  18. Vergleich der Einflußgrößen unterschiedlicher Prognosegruppen nach Subarachnoidalblutung

    OpenAIRE

    Scheffer, Petra

    2008-01-01

    In this retrospective study the quality of life and the outcome of patients after spontaneus non-traumatic subarachnoid hemorrhage (SAH) was assessed. The follow-up was performed in two groups: 172 patients after aneurysmal SAH and 42 patients after SAH without a proven source of bleeding. Clinical and neuroradiological variables and particularly the results of daily Transcranial Doppler sonography (TCD) were considered. For the evaluation of the neurological outcome the Glasgow Outcome Scale...

  19. Der Wiederaufbau Narvas nach 1944 und die Utopie der "sozialistischen Stadt" / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2004-01-01

    Nõukoguliku arhitektuuripoliitika põhimõtetest, "sotsialistliku linna" teoreetilisest ideaalist ja selle ideaali praktilisest teostusest Narvas. Narva vanalinna saatusest. 1944. aastal asuti vana Narva kohale rajama sisuliselt uut linna, Narva ehitamist mõjutas eelkõige asjaolu, et seal sai alguse uraanitootmine NSV Liidus

  20. Biotechnologische Nutzung der Schwerelosigkeit für medizinische Forschung - Analyse humaner Zellen nach Schwerelosigkeit

    DEFF Research Database (Denmark)

    Grimm, Daniela Gabriele; Bauer, Johann; Hemmersbach, Ruth

    2013-01-01

    health problems of space travellers and in parallel we get new information concerning several diseases of humans on Earth. Surprisingly, we also observed that single cells exposed to simulated microgravity assemble to three-dimensional aggregates resembling the tissues from which these cells...

  1. Similarities and Differences Between Yoruba Traditional Healers (YTH) and Native American and Canadian Healers (NACH).

    Science.gov (United States)

    Adekson, Mary Olufunmilayo

    2016-10-01

    Indigenous people of the world have used the services of medicine men and traditional healers from time immemorial. According to the World Health Organization, 80 % of the world's populations consult traditional healers. With an emerging globalization of health services in the world, there is a need for western mental health practitioners to learn and understand the practices of indigenous healers across the globe. This paper will not only highlight the similarities and differences between Yoruba traditional healers of Western Nigeria and Native American and First Nation Canadian traditional healers, but it will also allow practitioners to gain clearer perspectives of indigenous clients from Yoruba land and those from the United States of America and Canada. This ultimately will inform culturally sensitive clinical practice with these populations.

  2. Alles Banane? Fiktionale Erinnerung an DDR und Wende in den ersten zwanzig Jahren nach dem Mauerfall

    NARCIS (Netherlands)

    Maczka, Iwona Maria

    2010-01-01

    How are the GDR and the fall of the Berlin Wall remembered? The dissertation “Alles Banane?” deals with this question. It assumes that identity, individual as well as collective, is a social, cultural and political construction based on the memory of the past. This construction is not only

  3. Muskuläre Funktionsdefizite nach Hüft- und Knietotalendoprothese

    Directory of Open Access Journals (Sweden)

    Bochdansky T

    2008-01-01

    Full Text Available Ausgehend vom Modell einer Funktionseinheit von 4 Systemen (passives Knochen-Bindegewebe- System, aktives Muskel-Sehnen-System, nerval-humorales Kontrollsystem und metabolischvaskuläres Energiesystem ist es augenfällig, dass eine Störung eines Teilsystems immer mit einer Funktionsstörung der jeweiligen anderen Systeme einhergehen muss. Eine Strukturstörung (z. B. Gelenksoperation ist immer auch mit einer Funktionsstörung verknüpft, wobei der Schmerz eine wesentliche Rolle spielt. Eine physikalische Funktionsdiagnostik hat die Aufgabe, versteckte Funktionsdefizite zu erkennen und entsprechende Therapiekonzepte zu beurteilen. Wir führten dies mit Hilfe von elektromyographischen Untersuchungen (Oberflächen-EMG am M. quadriceps durch. Vorläufige Ergebnisse der maximalen willkürlichen isometrischen Kontraktion an bisher 65 Patienten zeigen bereits vor Knie- oder Hüfttotalendoprothesen-Operationen eine Seitendifferenz von 70,3 % Aktivität im Vergleich zur nicht zu operierenden Seite. Postoperativ war die Aktivität auf 22,5 % gesunken. 3 Wochen postoperativ stieg die Aktivität – gemessen an einer Untereinheit von 26 Patienten – dann auf 49,9 % an. Funktionstests wie der Tinetti-Test, Timed-up-and-go-Test oder die Gehzeit über 10 Meter zeigten ebenfalls beträchtliche Defizite, die jedoch mittels EMG deutlicher darzustellen waren. Da diese Defizite längerfristig zu weiteren Schäden führen können ("hip-spine"-Syndrom, ist das Erkennen und spezifische Behandeln von "versteckten" Defiziten für die postoperative Nachbehandlung von großer Bedeutung.

  4. "Doing pupil" nach Schulschluss – Videografie an einer Kinderuniversität

    Directory of Open Access Journals (Sweden)

    Alexandra König

    2015-03-01

    Full Text Available Auf der Basis einer Videografie an einer Kinderuniversität wird in dem vorliegenden Beitrag die Frage verfolgt, wie an einem außerschulischen Lernort generationale Ordnung hergestellt wird und welche Gestalt diese annimmt. Als heuristischer Rahmen dient das Modell der "Sozialisation als generationales Ordnen" (BÜHLER-NIEDERBERGER 2011; BÜHLER-NIEDERBERGER & TÜRKYILMAZ 2014. Die Analyse der ersten Sitzungen von zwei kontrastiven Kursen an der Kinder- und Jugenduniversität zeigt erstens, wie Kinder struktursensitiv Regeln in dem unbekannten Kontext erspüren, erarbeiten und modifizieren, wie sie KomplizInnen in der Herstellung generationaler Ordnung sind. Zweitens wird die Dominanz der schulischen Ordnung und des SchülerInnenstatus für Kindheit deutlich. Die Kinder stellen "Schule" her – paradoxerweise auch in einem außerschulischen Kontext. Drittens wird im kontrastiven Vergleich der untersuchten Kurse eine Varianz dieser Ordnungen – in Bezug auf die Form des Wissens und Adressierung der Kinder – herausgearbeitet, die allerdings die Dominanz der schulischen Ordnung nicht bricht. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs150263

  5. Postoperative MR study of the ankle. Postoperative kernspintomographische Untersuchung des oberen Sprunggelenks nach Aussenbandnaht

    Energy Technology Data Exchange (ETDEWEB)

    Tosch, U.; Sander, B.; Schubeus, P. (Klinikum Rudolf Virchow, Berlin (Germany). Strahlenklinik und Poliklinik); Tepe, H.; Goudarzi, Y.M. (Klinikum Rudolf Virchow, Berlin (Germany). Unfallchirurgische Klinik)

    1991-12-01

    20 patients with acute traumatic rupture of the anterior talofibular ligament and ligamental suture were studied postoperatively by MRI. MR results were correlated with stress X-ray studies. We found a normal anterior talofibular ligament in eight cases. However, stress X-ray images showed normal stability of the ankle joint in eighteen cases. In six patients the anterior talofibular ligament was thickened, in another six cases it could not be separated from scar tissue. Therefore MR imaging of ankle ligaments did not allow a diagnosis of their function. Nevertheless, sequelae of the ankle trauma such as osteochondrosis, exsudation into the ankle joint and tendovaginitis of the flexor muscles were sensitively visualised by MR. (orig.).

  6. Alexander von Humboldt brachte Guano nach Europa - mit ungeahnten globalen Folgen

    Directory of Open Access Journals (Sweden)

    Bärbel Rott

    2016-05-01

    Full Text Available Zusammenfassung Die vorliegende Abhandlung beschäftigt sich mit einem bisher wenig beachteten Aspekt von Humboldts Amerikanischer Reise (1799─1804. Während seine Studien der Pflanzen- und Tierwelt bis heute große Aufmerksamkeit genießen, wird Humboldts Beitrag zu der Entwicklung der modernen Landwirtschaft wenig beachtet. Während seines Aufenthalts in Lima erhielt er Proben von Guano, Vogelmist von den Chincha-Inseln vor der peruanischen Küste. Einige Proben, die er von dieser Reise zurückbrachte, wurden von Wissenschaftlern in Frankreich und Deutschland untersucht. Die Analysenergebnisse zeigten außerordentlich hohe Gehalte an Pflanzennährstoffen, insbesondere Stickstoff und Phosphor. In den folgenden Jahrzehnten wurde Guano zu einem bedeutsamen Düngemittel und Auslöser eines Booms in Europa und Peru. Die Auswirkungen dieser Entwicklung sind bis heute sichtbar und werden hier unter besonderer Beachtung von Phosphor beschrieben. Abstract One aspect of Humboldt’s travel to South America (1799─1804 received little attention. The fascination of his studies of the South American flora and fauna is unbroken to the present day. Yet Humboldt’s contribution to modern agriculture remains almost unnoticed. During his stay in Lima Humboldt received samples of guano, a mixture of bird droppings from the Chincha Islands off the Peruvian coast, which he took to Europe and had analyzed by the most famous chemists in France and Germany. The results showed outstanding fertilizing effects, in particular due to the high content of nitrogen and phosphorus. The ensuing boom starting from the 1840s influenced agriculture in Europe and the economy of Peru seriously. Some aspects of this historical development may give an idea of the ensuing change not only in agriculture. Résumé Il y a un aspect du voyage de Alexander von Humboldt en Amérique du Sud (1799─1804 qui jusqu’à présent a été peu considéré. Ses études de la flore at le da faune de l’Amérique du Sud ont attiré une large attention du public. Or, son influence au développement de l´agriculture moderne est plutôt ignoré. Pendant son séjour à Lima, Humboldt reçut des échantillons de guano qui est composé des excréments d’oiseaux des Iles Chincha face à la côte du Pérou. Humboldt les faisait examiner par des scientifiques français et allemands. Les résultats des analyses montraient des teneurs extraordinaires de nutriments pour plantes, en particulier d´azote et de phosphore. Pendant les décennies suivantes le guano devenait une source indispensable comme fertilisant et a créé un boom en Europe et au Pérou. L’impact de ce développement qui est perceptible jusqu’à nos jours est décrit ci-dessous.

  7. Soziale Unterstützung, interpersonale Probleme, Inanspruchnahme medizinischer Leistungen und postoperative Komplikationen nach aortokoronarer Bypassoperation

    OpenAIRE

    Renz, Diane Miriam Esther

    2005-01-01

    This study examines the relationship between psychosocial stress before coronary surgery and the amount of health care utilization during postoperative hospitalization in a sample of 115 patients. The aim of the study is to test the hypothesis that there is a correlation between a high psychosocial stress profile and the utilization of medical care (so called „high utilizers”). The sample consists of 80,9% men and 19,1% women aged between 34 and 78 years. Psychosocial stress was assessed with...

  8. Uhren, die nach dem Mond gehen - Einfluss des Mondes auf die Erde und ihre Lebewesen

    OpenAIRE

    Engelmann, Wolfgang

    2009-01-01

    Der Mond beeinflußt nicht nur die Wasser- und Landmassen der Erde, sondern auch die Lebewesen. Das betrifft vor allem Organismen der Meere und der Küsten. Als Beispiele für Gezeitenrhythmen werden die Vertikalwanderungen der Kieselalge Hantzschia virgata, die Aktivität der Strandassel Excirolana chiltoni und der Wassergehalt in Holzstämmen beschrieben. Tages-, Monats- und Jahresablagerungen wurden bei Fossilien beobachtet. Vierzehntägige Rhythmen zeigt der Ährenfisch Leuresthes tennis beim La...

  9. Die Suche nach dem verschollenen Großsteingrab G4 'Onner es' (Onnen, Prov. Groningen)

    NARCIS (Netherlands)

    Groenendijk, Hendrik; Lanting, JN; Woldring, H

    2014-01-01

    On the eastern hillside of the Hondsrug near the hamlet Onnen (Gr.), a scatter of surface finds led to the belief that a megalithic grave (hunebed) must have been present on the Onner es. Through soil radar, test excavation, pollen analysis and coring, the former location of the presumed hunebed was

  10. District heating in Dresden six months after the flood; Dresdner Fernwaermeversorgung: 6 Monate nach der Flut

    Energy Technology Data Exchange (ETDEWEB)

    Lehmann, B. [Drewag - Stadtwerke Dresden GmbH (Germany)

    2003-02-01

    The catastrophic floods in August 2002 caused damage totalling Euro 9.6 million to the district heating networks of Drewag - Stadtwerke Dresden GmbH. The damage to heat exchanger stations, compact stations and local heating plants was repaired by 31 January 2003. The situation regarding the repair of the district heating networks is more problematic. After the flood, repair work was begun by pumping out the buildings, repairing the heat exchanger stations, the downstream compact stations and the local heating plants and restoring them to use. This included the replacement of all the electrical and some of the mechanical components, and the construction of temporary feeds. Damage to these components alone amounted to Euro 2 million. Initially, an attempt was made to dry electrical components by various means, in order to re-use them. This was successful in some cases, but the failure rate reached 80% after a few days of operation, so a general decision was made to use only new parts, with the exception of electric motors with a rating over 2 kW. These motors were dismantled and dried with dehumidifiers for up to 60 hours. Only one of the approximately 40 motors dried by this process subsequently failed, due to a short circuit in the winding. It was possible to rectify all such damage by 31 January 2003, i.e. removal of all the temporary arrangements for ensuring the district heating supply was also completed. The same trend was evident in the repair of local heating plants. Damage to this plant amounted to Euro 0.74 million. Euro 0.6 million had been spent on this category of repair by 31 January 2003. (orig.) [German] Der durch die Flutkatastrophe im August 2002 enstandene Schaden im Bereich der Fernwaermenetze der Drewag betraegt insgesamt 9,6 Mio. Euro. Bis zum 31. Januar 2003 konnten die versorgungswirksamen Schaeden im Bereich der Waermeuebertrager- und Kompaktstationen sowie der Nahwaermeanlagen beseitigt werden. Problematischer ist die Situation bei der Instandsetzung der Fernwaermenetze, die bis in das Jahr 2005 dauern wird. (orig.)

  11. Rußland und die GUS : auf der Suche nach einem neuen Modell wirtschaftlicher Zusammenarbeit

    OpenAIRE

    Grinberg, Ruslan; Kosikova, Lidija

    1997-01-01

    'Im Dezember 1996 beging die Gemeinschaft Unabhängiger Staaten (GUS) den fünften Jahrestag ihrer Gründung. In dem zurückliegenden Zeitraum haben im System der wirtschaftlichen Verbindungen Rußlands mit den übrigen ehemaligen Unionsrepubliken der UdSSR sowie aller GUS-Länder mit der übrigen Welt tiefgreifende Veränderungen stattgefunden. Zum ersten haben die gegenseitigen Beziehungen rasch und unumkehrbar den Charakter binnenwirtschaftlicher Verbindungen im Rahmen eines einheitlichen, unter de...

  12. Heiligenverehrung nach Luther. Die heilige Birgitta im nachreformatorischen Schweden und im Ostseeraum.

    Directory of Open Access Journals (Sweden)

    Stephan Flemmig

    2009-12-01

    Full Text Available Though Sweden’s public perception – both at home and abroad – is that of a strongly Lutheran country, the role that Birgitta of Sweden (1303–1373 plays in modern Swedish historical awareness cannot be overstated. At the same time, Birgitta’s presence is also evident all over the Baltic Sea region – Birgitta being the patron saint of the Order of the Birgittines, which was re-established in historical Birgittine places in the 20th century throughout Scandinavia as well as in post-Communist Poland and Estonia. Birgitta is also referred to as the “Patron Saint of Europe”, and she is one of the most thoroughly researched female personalities of medieval Scandinavia. This essay focuses primarily on Birgitta’s adoption in 16th – 18th century Sweden, and secondly on the re-newed interest in Birgitta and her order in present day Sweden. This essay also discusses the medieval spreading of the Order in the Baltic and its re-establishment in modern times.

  13. "Der Bleistift roch nach Rosmarin": the art of foraging in Stifter, Handke, and Beuys.

    Science.gov (United States)

    Brady, Martin

    2012-01-01

    Taking as its starting point the notion of ‘reading’ as ‘gathering’, implied by the word Lesen, this essay examines some correspondences between foraging, naming, writing, drawing, and reading to establish a clear distinction between foraging and collecting more generally. By way of example, three kinds of foraging are addressed: berry picking, in Adalbert Stifter's short story Der Waldsteig; mushroom collecting, in Peter Handke's fairy-tale Lucie im Wald mit den Dingsda; gathering medicinal herbs, in particular rosemary, in the drawings, performances, and social sculptures of Joseph Beuys (including Manresa, Barraque D’dull Odde, Geruchsplastik, Blitzschlag mit Lichtschein auf Hirsch). In the literary and visual works discussed here, foraging and its products are therapeutic both physically and spiritually, what Handke terms ‘traumerweiternd’. Moreover, in the case of Beuys in particular this healing process has explicitly social and political implications. The essay also examines foraging as an analogy for the construction of meaning and concludes with a discussion of the clearing as a privileged space in which foraging and gathering, both literally and figuratively, can take place.

  14. Functional MRI of the cervical spine after distortion injury; MR-Funktionsdiagnostik der Halswirbelsaeule nach Schleudertrauma

    Energy Technology Data Exchange (ETDEWEB)

    Schnarkowski, P. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Weidenmaier, W. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Heuck, A. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Reiser, M.F. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik

    1995-04-01

    50 patients with a history of distortion injury of the cervical spine were examined with static and functional MRI. Functional MRI consisted of different patient`s positions from maximal extension to maximal flexion (30 , 0 , 25 , 40 , 50 ). T{sub 2}*-weighted gradient echo sequences were performed in a sagittal view for the different positions. Ligamentous instabilities and disc protrusions were seen only in functional MRI in 17 patients. These findings correlated with the neurological symptoms. Two patients were treated by operative fusion because of these findings. (orig.) [Deutsch] Bei 50 Patienten mit einem Schleudertrauma der Halswirbelsaeule wurden zu den statischen Magnetresonanztomogrammen der Halswirbelsaeule MR-Funktionsaufnahmen durchgefuehrt. Diese Funktionsaufnahmen erfolgten in 5 verschiedenen Flexionsgraden von maximaler Reklination bis zur maximalen Inklination (30 , 0 , 25 , 40 , 50 ). T{sub 2}*-gewichtete Gradienten-Echo-Sequenzen in sagittaler Schnittfuehrung wurden fuer jeden Flexionsgrad angefertigt. Bandinstabilitaeten und Bandscheibenvorwoelbungen konnten bei 17 Patienten nur in bestimmten Flexionsgraden erfasst werden. Diese 17 Patienten zeigten eine umschriebene neurologische Symptomatik, die von ihrer Lokalisation mit den in der MR-Funktionsdiagnostik erhobenen Befunden korrelierten. Zwei Patienten wurden aufgrund diese Befunde mit einer operativen Fusion therapiert. (orig.)

  15. Nach dem ‚narrative turn‘. Handbücher und Lexika des 21. Jahrhunderts

    Directory of Open Access Journals (Sweden)

    Michael Scheffel

    2012-12-01

    Full Text Available Recent years have seen the appearance of numerous lexica and handbooks de-voted to general narratological questions which collect contributions from dif-ferent disciplines. What are the strengths and weaknesses of these books (each of which is aimed at a large readership? What kind of knowledge is provided, and what understanding of narratology is codified, in these works? This contri-bution approaches these questions in the form of an overview, and arrives at the following conclusion: If narratology is to become a truly transdisciplinary pro-ject, genuine theoretical and methodological exchange between neighboring dis-ciplines needs to be intensified. After the period of expansion in research fields and the current phase of consolidation (as documented in such handbooks and lexica, a closer focus on transdisciplinary collaboration would mark a new step in the development of narratological research.

  16. Neues Punktionsinstrumentarium: Provox-Vega®-Punktionsset: Anwendung beim Einbringen einer Stimmprothese nach Laryngektomie

    NARCIS (Netherlands)

    Lorenz, K.J.; Hilgers, F.M.; Maier, H.

    2013-01-01

    Background The use of voice prostheses has been considered the gold standard in voice rehabilitation following laryngectomy for the last 20 years. Insertion is generally performed as a primary procedure during laryngectomy or as a secondary procedure with a re-usable trocar or rigid esophagoscope, a

  17. Long-term results after primary infrapopliteal angioplasty for limb ischemia; Langzeitergebnisse nach Ballonangioplastie kruraler Arterien

    Energy Technology Data Exchange (ETDEWEB)

    Alfke, H. [Klinikum Luedenscheid (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Vannucchi, A. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Froelich, J.J. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Klinikum Bad Hersfeld (Germany). Klinik fuer Radiologie und Nuklearmedizin; El-Sheik, M.; Wagner, H.J. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Vivantes-Klinikum im Friedrichshain (Germany). Inst. fuer Radiologie und Interventionelle Therapie

    2007-08-15

    Purpose: To evaluate the technical success rate, procedure-related complications, and clinical long-term results for patients who underwent infrapopliteal angioplasty. Materials and Methods: We retrospectively evaluated all patients who underwent infrapopliteal angioplasty to treat critical chronic limb ischemia or severe claudication from 1/1997 to 12/1999. We excluded patients with acute (< 2 weeks) limb ischemia. Procedure-related data were prospectively documented in a database and analyzed with a focus on the technical success rate and procedure-related complications. In addition all clinical documents were analyzed, and a follow-up examination was performed or telephone interviews were conducted with patients, relatives and referring doctors for follow-up. The primary end points were the limb salvage rate and patient survival rate. The secondary end points included the complication rate, technical success rate, and walking distance. Results: 112 patients with a mean age of 72 years (41 women, 71 men) underwent crural angioplasty on 121 limbs. Four patients suffered from severe claudication (Rutherford category 3) and all others had critical chronic limb ischemia (category 4 to 6). The complication rate was 2.7 %. The technical success rate was 92 %. The ankle brachial index increased from 0.59 to 0.88. The mean walking distance increased significantly from 52 {+-} 66 to 284 {+-} 346 meters at the time of follow-up. The limb salvage rate was 83.6 % after one year and 81.1 % after three years. The mean survival rate according to Kaplan-Meier was 79.4 %, 69.2 %, and 54.2 % at 1, 2, and 3 years, respectively. Patients with at least one patent run-off vessel after angioplasty had a significantly better limb salvage rate. Diabetes was not a risk factor for limb salvage. Conclusion: Infrapopliteal angioplasty shows a high technical success rate with an acceptable complication rate. The clinical long-term success seems favorable if a least one open run-off vessel was able to be achieved. However, the survival rate was limited by the co-morbidity in this patient group. (orig.)

  18. Radiologic diagnosis before and after liver transplantation. Radiologische Diagnostik vor und nach Lebertransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Galanski, M. (Medizinische Hochschule Hannover (Germany). Abt. Diagnostische Radiologie 1); Ringe, B. (Medizinische Hochschule Hannover (Germany). Abt. Abdominal- und Transplantationschirurgie)

    1992-05-01

    The main function of imaging procedures before liver transplantation is the exclusion of factors that may either constitute cotraindications to surgery or necessitate a modification of the operation technique. Ultrasound and MRI are the modalities best suited for this purpose. After transplantation, imaging procedures are required mainly for diagnosis of and differentiation, in particular, between vascular and biliary complications, rejection, and infection, since these postoperative complications very often cannot be reliably differentiated on the basis of clinical and laboratory parameters alone. As vascular disturbances can vary widely in their presentation and can mimic other complications, duplex Doppler sonography plays a dominant role in clarification of the perfusion status of the graft. If infection is suspected, ultrasound generally has to be supplemented by other imaging procedures, such as CT or MRI; if these techniques reveal suggestive lesions, a fine-needle aspiration is mandatory in most cases. Invasive procedures such as angiography or PTCD are now applied only in selected cases, especially if an intervention is contemplated. Rejection cannot be reliably diagnosed by any of the imaging techniques and still requires biopsy. (orig.).

  19. Sekundärinsolvenzverfahren nach der Europäischen Insolvenzverordnung

    DEFF Research Database (Denmark)

    Ringe, Georg

    2013-01-01

    an economic activity with a “minimum of organisation and certain stability”. This decision stands in conformity with the leading academic comment and other case-law. Nevertheless, the decision is a good opportunity to stress the importance of secondary proceedings and their function to protect local creditors...

  20. Subdivision of Holocene Baltic sea sediments by their physical properties [Gliederung holozaner ostseesedimente nach physikalischen Eigenschaften

    Science.gov (United States)

    Harff, Jan; Bohling, G.C.; Endler, R.; Davis, J.C.; Olea, R.A.

    1999-01-01

    The Holocene sediment sequence of a core taken within the centre of the Eastern Gotland Basin was subdivided into 12 lithostratigraphic units based on MSCL-data (sound velocity, wet bulk density, magnetic susceptibility) using a multivariate classification method. The lower 6 units embrace the sediments until the Litorina transgression, and the upper 6 units subdivide the brackish-marine Litorina- and post-Litorina sediments. The upper lithostratigraphic units reflect a change of anoxic (laminated) and oxic (non-laminated) sediments. By application of a numerical stratigraphic correlation method the zonation was extended laterally onto contiguous sediment cores within the central basin. Consequently the change of anoxic and oxic sediments can be used for a general lithostratigraphic subdivision of sediments of the Gotland Basin. A quantitative criterion based on the sediment-physical lithofacies is added to existing subdivisions of the Holocene in the Baltic Sea.

  1. Strebte Caesar nach dem Königtum? – Die Bedeutung der corona aurea

    Directory of Open Access Journals (Sweden)

    Christian Wölfelschneider

    2011-11-01

    Full Text Available Did Julius Caesar aspire to kinghsip at the time he was in power? The seminar-paper of Christian Wölfelschneiders approaches this question. On the basis of contradictory sources and several ancient authors which maintain different points of view there remains a very diffuse picture of the actual historical events. Initially the personal motivations of Ceaser cannot be cleared to a satisfying degree. Crucial clues for answering the question of Caesars aspiraton to kingship can be deduced from the corona aurea. The wearing of this old Etruskian crown device can be proven for the first time for the celebration of the feast of Lupercalia on the 15th of February in 44 b.C. On this day the mighty dictator appeared in public wearing a scarlet toga with golden shoes and the corona aurea and therefore caused a stir. After a detailled comparison of the different historical accounts a conclusion is drawn that the golden collar of Ceasar cannot be regarded as a kingly crown. The contemporary symbol for kingship was indeed a diadem of hellenistic design which Ceasar, in turn, refused to wear. Another argument is the rejection of the title rex. Therefore, Julius Caesar did not aspire to kingship. His king-like position in the Roman Empire did not need a furhter symbolical justification.

  2. Kompromiss für UN-Weltgipfel zur Informationgesellschaft nach Verhandlungsmarathon gefunden

    CERN Multimedia

    Kleinwächter, Wolfgang

    2003-01-01

    At 14.43 local time, after a full week of discussions and several interruptions, it was achieved. After two years of negociations before the first president steps to the rednerpult of the world summit

  3. Prospektive Entwicklung des postoperativen Sprachverstehens nach Tympanoplastik bei chronischer Otitis media

    OpenAIRE

    Knof, B; Plotz, K; Krack, A; Stumper, J; Schönfeld, R

    2013-01-01

    Einleitung: Tympanoplastiken I/III bei chron. Otitis media COM (mesotympanalis CMOM und epitympanalis CEOM). In der Literatur werden erfolgreiche operative Behandlungen mit Verringerung der Schallleitungskomponente (air-bone gap) belegt (Gierke et al. 2011). Aus Sicht des Patienten steht die Verbesserung des Hörvermögens und des Sprachverstehens im Alltag im Vordergrund. Das Ziel war die Untersuchung der Entwicklung des Hörvermögens in Ruhe sowie im Störgeräusch.Methoden: An den Hör- und Sp...

  4. Vaterschaft nach der Scheidung – Die Perspektive der Väter

    Directory of Open Access Journals (Sweden)

    Michael Matzner

    2004-11-01

    Full Text Available Während man in Deutschland die Situation von allein erziehenden Müttern gut erforscht hat, wandte man sich den von ihren Kindern getrennt lebenden Vätern nur äußerst selten zu. Dies ist mehr als erstaunlich, wenn man sich die in die Millionen gehende Zahl betroffener Väter und Kinder vor Augen führt. Allein im Jahr 2000 wurden 95.000 Ehepaare mit minderjährigen Kindern (146.000 geschieden. Bei Gerhard Amendts empirischer Studie handelt es sich um die erste deutschsprachige, als Buch erschienene wissenschaftliche Veröffentlichung zum Thema „Scheidungsväter“. Amendt beantwortet aus der Perspektive der Väter folgende Fragen: Wie sprechen Väter über ihre Scheidung und wie gehen sie mit den Scheidungsfolgen um? Wie verbringen sie die Zeit mit ihren Kindern? Warum brechen manche von ihnen den Kontakt zu den Kindern ab? Der neue Zugang zum Thema Scheidung bzw. Trennung über die Person des Vaters war längst überfällig und bringt neue Perspektiven und Erkenntnisse in die wissenschaftliche Debatte.

  5. Auf der Suche nach historischen Phrasemen – oder: Wörterbücher als Korpora

    Directory of Open Access Journals (Sweden)

    Dräger, Marcel

    2009-01-01

    Full Text Available The treatment of phrasemes is problematic both in a lexicographic view and a corpus analytic view, even though the efforts of the collocation research provide enormous amounts of output. Finding and automatically extracting phrasemes, that are longer than two or three word collocations, is still not satisfactorily possible, because there are no markers in the text, that indicate the borders of the expressions. If in addition the perspective is an historical one, the problems arise as the amount of available historical texts decreases. For an historical phraseographic analysis realistic examples are extremely help- and needful, so that other sources for assembling examples have to be found. The following text proposes some approaches, how dictionaries can be used as corpora, and shows, which results (examples, illustrations, links etc. can be expected. The point of origin of the idea is to use dictionaries not in the classical way – that means: searching the headword and reading the related article –, but to use the whole dictionary as a corpus. This inverse use of dictionaries allows us to find a lot of implicit lexikographic information, that in a normal way of using dictionaries could only be found by coincident.

  6. Was den polnischen Klempner in den Norden lockt. Zur heutigen Arbeitsmigration nach Norwegen und Schweden

    Directory of Open Access Journals (Sweden)

    Joanna Miszczuk

    2010-12-01

    Full Text Available In the course of the negotiations about the Eastern enlargement of the EU in 2004, objections were raised against the immediate enforcement of unrestricted freedom of movement of labour forces because of the possible destabilizing effects this could have on the labour markets as well as the welfare systems of the Western European member states. In order to avoid these effects, the vast majority of the member states reacted by introducing temporary arrangements and other regulations. A comparison made between the liberal policy of Sweden which did not introduce any regulations and the more restrictive case of Norway shows that the feared effects did not set in. The actual extent of migration depends foremost on the demand for labour force in the receiving countries. Regulations are leading to the search for alternative strategies in order to circumvent the existing restrictions.

  7. Indispensable fossil energy. Perception and reality; Unverzichtbare fossile Energie. Wahrnehmung und Wirklichkeit. Die Zeit nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Welte, Dietrich

    2012-07-01

    After the reactor accident in Fukushima, Germany called for an ''energy turning point'' and embarked upon a rapid exit from nuclear power. In addition to the current ''nuclear energy problem'' a further more diffuse challenge with regard to energy supply has existed for decades in particular in the Federal Republic: the anthropogenic CO2 emission. This is regarded by the public and in official policy as the main cause of global warming and is sensationalized particularly in the media as the reason for an imminent ''climatic disaster''. However, it is extremely important to understand how this sometimes highly polemic and demagogic debate on climate and energy arose in our country and how it has developed. Today, this debate still influences every discussion about a future energy strategy. But it would be better if a rethink concerning energy supply and the climate would lead to realistic assessments and measures. (orig.)

  8. Die Rolle sprachtherapeutischer Berufe in der Intervention kommunikativ pragmatischer Fähigkeiten bei Erwachsenen mit ASS (Autismus-Spektrum-Störung): Ein Aufruf zur Interdisziplinarität

    NARCIS (Netherlands)

    Carolin Schwenzfeier; Eva Wasser; Johanna Witthacke; Marita Brenneise; Antje Orgassa; Jan-Pieter Teunisse

    2015-01-01

    Hintergrund und Fragestellung: Erwachsene mit einer Autismus-Spektrum-Storung (ASS) ohne intellektuelle Beeintrachtigung (d. h. eine normale Sprachentwicklung und ein Intelligenzquotient von ≥85 liegen vor), weisen haufig Einschrankungen in der sozialen Interaktion und Kommunikation auf (American

  9. Die Bedeutung von Angststörungen für die Entwicklung von erhöhtem Alkoholkonsum und Alkoholstörungen bei Jugendlichen und jungen Erwachsenen

    OpenAIRE

    Zimmermann, Petra

    2003-01-01

    Hintergrund. In klinischen und epidemiologischen Untersuchungen wurden retrospektiv Assoziationen zwischen Angst- und Alkoholstörungen bestätigt. Bei Personen, die von beiden Störungen betroffen waren, fand man restrospektiv meist einen früheren Beginn der Angststörungen im Vergleich zu den Alkoholstörungen, was kausal im Sinne der Selbstmedikationshypothese interpretiert wurde. Diese konnte bisher nicht eindeutig bestätigt werden. Zur Aufklärung notwendige prospektive Untersuchungen, die Ang...

  10. CT-morphological characterization of respiratory syncytial virus (RSV) pneumonia in immune-compromised adults; Morphologische Charakterisierung und Verlaufsbeurteilung von Respiratory Syncytial Virus (RSV) Pneumonien bei immunkompromittierten Erwachsenen in der Thorax-CT

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, J.L.; Kauczor, H.U. [Univ. Hospital Heidelberg (Germany). Diagnostic and Interventional Radiology; Lehners, N.; Egerer, G. [Univ. Hospital Heidelberg (Germany). Internal Medicine V of Hematology, Oncoloy and Rheumatology; Heussel, C.P. [Thoracic Hospital at Univ. Hospital Heidelberg (Germany). Diagnostic and Interventional Radiology with Nuclear Medicine

    2014-07-15

    Characterization and follow-up evaluation of chest CT of RSV pneumonia in immune-compromised adults during a seasonal epidemic. Retrospective analysis of 132 chest CT examinations of 51 adult immune-compromised patients (29 m/22f, diameter 58 years) with clinical signs of pneumonia and positive RSV test in winter 2011/2012. Two experienced chest radiologists evaluated the morphology (bronchial wall thickening, tree-in-bud, nodules, halo, ground-glass opacities, consolidations, pleural fluid) of the CT scans by consensus. Pathological findings were in 86 % of the chest CT scans: Areas of ground-glass attenuation in 64 %, consolidations in 56 %, nodules in 55 % (diameter 8 mm in maximal diameter, with halo in 71 %), pleural fluid in 44 % (diameter 2 cm), tree-in-bud in 36 %, bronchial wall thickening in 27 % and more than one morphological finding in 72 %. There were no pathological CT findings in 14 % of patients with clinical symptoms of pneumonia because these patients did not undergo follow-up. Radiological progression was found in 45 % of patients and regression in 33 % in follow-up examinations. In 37 % an additional examination of the paranasal sinuses was performed and showed sinusitis in 63 % of cases. 90 % of the patients had sinusitis as well as pneumonia. In addition to RSV, a further pathogenic agent was found in bronchoalveolar lavage of five patients (Aspergillus spec., herpes simplex virus, Pseudomonas aeruginosa). The most characteristic signs in chest CT scans were at the beginning of pneumonia with nodules and tree-in-bud often combined with bronchial wall thickening. The following CT scans showed characteristic but not pathognomonic chest CT findings of RSV pneumonia. These morphological findings should be recognized seasonally (winter) especially at the beginning of the case of pneumonia. RSV-associated additional sinusitis is probably common and should be noticed.

  11. Vertically transmitted HPV-dependent squamous cell carcinoma of the external auditory canal. Case report of a child

    Energy Technology Data Exchange (ETDEWEB)

    Snietura, Miroslaw; Pakulo, Slawomir; Kopec, Agnieszka; Piglowski, Wojciech; Stanek-Widera, Agata [Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Tumor Pathology Department, Gliwice (Poland); Chelmecka-Wiktorczyk, Liliana [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Drabik, Grazyna [University Children' s Hospital of Cracow, Pathology Department, Cracow (Poland); Kosowski, Bogdan [NZOZ Prosmed, Cracow (Poland); Wyrobek, Lukasz [University Children' s Hospital of Cracow, Department of Radiology, Cracow (Poland); Balwierz, Walentyna [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Jagiellonian University in Cracow, Clinic of Oncology and Hematology, Polish-American Pediatric Institute, Cracow (Poland)

    2017-02-15

    -negative Tumoren des Kopf- und Halsbereichs treten vor allem bei Erwachsenen auf und sind bei Kindern eine Seltenheit. Daher begruendete die Diagnose eines Plattenepithelkarzinoms des aeusseren Gehoergangs bei einem 2-jaehrigen Kind die Notwendigkeit, die Krankheit eingehend zu untersuchen und zu beschreiben. Wir berichten ueber ein 2-jaehriges Maedchen, das von einer HPV-positiven Mutter geboren wurde, bei der waehrend der Schwangerschaft Gebaermutterhalskrebs diagnostiziert worden war. Die Geburt erfolgte per Kaiserschnitt. Die Mutter erlag 7 Monate nach der Geburt ihrer Krebserkrankung. Das Kind wurde nach der Diagnose eines lokal fortgeschrittenen HPV-positiven Plattenepithelkarzinoms des aeusseren Gehoergangs operativ und ergaenzend mit Radio- und Chemotherapie behandelt. Erreicht wurde eine komplette Remission fuer mindestens 325 Wochen nach Beginn der Behandlung, sodass mehr als 6 Jahre keine Krankheitssymptome aufgetreten sind. Dies ist die erste Fallbeschreibung eines stark fortgeschrittenen HR-HPV-positiven HNSCC des aeusseren Gehoergangs bei einem 2-jaehrigen Kind, bei dem nach Anwendung einer nichtradikalen chirurgischen Behandlung sowie einer Chemo- und Strahlentherapie eine spektakulaere Reaktion und ein aktuell 6-jaehriges krankheitsfreies Ueberleben erreicht wurden. Dieser Fall bestaetigt die Beobachtungen, nach denen HNSCC-Tumoren im Zusammenhang mit HR-HPV guenstig auf die Behandlung ansprechen - trotz des klinisch fortgeschrittenen Tumorstadiums und des jungen Patientenalters. (orig.)

  12. After the EEG is before the EEG. Subsidisation of renewable energy plants under the PV amendment of 2012; Nach dem EEG ist vor dem EEG. Die Foerderung von Erneuerbare-Energien-Anlagen nach der PV-Novelle 2012

    Energy Technology Data Exchange (ETDEWEB)

    Oppen, Margarete von [Sozietaet Geiser und von Oppen, Berlin (Germany); Gross, Rene [Bundesverband Solarwirtschaft e.V., Berlin (Germany)

    2012-08-15

    On 28 June 2012, following an agreement proposal by the mediation committee, the German parliament was at last able to cast its final vote on the ''Law Amending the Legal Framework for Electricity from Solar Radiation Energy and Further Changes to the Law Governing Renewable Energy Resources (in the following: EEG), which had initially already been agreed on in late March 2012. The present article endeavours to give a practice-oriented overview of the current regulatory status concerning the subsidisation of electricity from solar radiation energy.

  13. Electrical field stimulation causes oxidation of exogenous histamine in Krebs-Henseleit buffer: A potential source of error in studies of isolated airways

    NARCIS (Netherlands)

    A.R. Hulsmann (Anthon); R.H. Raatgeep (Rolien); I.M. Garrelds (Ingrid); A.W. van Toorenenbergen (Albert); J.C. de Jongste (Johan)

    1993-01-01

    textabstractElectric field stimulation (EFS) relaxes human histamine-precontracted airways in vitro. This relaxation is only partly neurally mediated. Nonneural relaxation has been also shown in blood vessels and is due to the generation of oxygen radicals by EFS. In isolated airways the origin of

  14. Phosphorylation in vivo of non-ribosomal proteins from native 40 S ribosomal particles of Krebs II mouse ascites-tumour cells

    DEFF Research Database (Denmark)

    Schuck, J; Reichert, G; Issinger, O G

    1981-01-01

    Four non-ribosomal proteins from native 40 S ribosomal subunits with mol.wts. of 110 000, 84 000, 68 000 and 26 000 were phosphorylated in vivo when ascites cells were incubated in the presence of [32P]Pi. The 110 000-, 84 000- and 26 000-dalton proteins are identical with phosphorylated products...... from native 40 S subunits after phosphorylation in vitro by a cyclic nucleotide-independent protein kinase. Phosphoserine was the major phosphorylated amino acid of the proteins phosphorylated in vivo and in vitro....

  15. Treatment with tianeptine induces antidepressive-like effects and alters the neurotrophin levels, mitochondrial respiratory chain and cycle Krebs enzymes in the brain of maternally deprived adult rats.

    Science.gov (United States)

    Della, Franciela P; Abelaira, Helena M; Réus, Gislaine Z; Santos, Maria Augusta B dos; Tomaz, Débora B; Antunes, Altamir R; Scaini, Giselli; Morais, Meline O S; Streck, Emilio L; Quevedo, João

    2013-03-01

    Maternally deprived rats were treated with tianeptine (15 mg/kg) once a day for 14 days during their adult phase. Their behavior was then assessed using the forced swimming and open field tests. The BDNF, NGF and energy metabolism were assessed in the rat brain. Deprived rats increased the immobility time, but tianeptine reversed this effect and increased the swimming time; the BDNF levels were decreased in the amygdala of the deprived rats treated with saline and the BDNF levels were decreased in the nucleus accumbens within all groups; the NGF was found to have decreased in the hippocampus, amygdala and nucleus accumbens of the deprived rats; citrate synthase was increased in the hippocampus of non-deprived rats treated with tianeptine and the creatine kinase was decreased in the hippocampus and amygdala of the deprived rats; the mitochondrial complex I and II-III were inhibited, and tianeptine increased the mitochondrial complex II and IV in the hippocampus of the non-deprived rats; the succinate dehydrogenase was increased in the hippocampus of non-deprived rats treated with tianeptine. So, tianeptine showed antidepressant effects conducted on maternally deprived rats, and this can be attributed to its action on the neurochemical pathways related to depression.

  16. The human Krebs cycle 2-oxoglutarate dehydrogenase complex creates an additional source of superoxide/hydrogen peroxide from 2-oxoadipate as alternative substrate.

    Science.gov (United States)

    Nemeria, Natalia S; Gerfen, Gary; Guevara, Elena; Nareddy, Pradeep Reddy; Szostak, Michal; Jordan, Frank

    2017-07-01

    Recently, we reported that the human 2-oxoglutarate dehydrogenase (hE1o) component of the 2-oxoglutarate dehydrogenase complex (OGDHc) could produce the reactive oxygen species superoxide and hydrogen peroxide (detected by chemical means) from its substrate 2-oxoglutarate (OG), most likely concurrently with one-electron oxidation by dioxygen of the thiamin diphosphate (ThDP)-derived enamine intermediate to a C2α-centered radical (detected by Electron Paramagnetic Resonance) [Nemeria et al., 2014 [17]; Ambrus et al. 2015 [18

  17. [Activity of liver mitochondrial NAD+-dependent dehydrogenases of the krebs cycle in rats with acetaminophen-induced hepatitis developed under conditions of alimentary protein deficiency].

    Science.gov (United States)

    Voloshchuk, O N; Kopylchuk, G P

    2016-01-01

    Activity of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase, malate dehydrogenase, and the NAD(+)/NADН ratio were studied in the liver mitochondrial fraction of rats with toxic hepatitis induced by acetaminophen under conditions of alimentary protein deprivation. Acetaminophen-induced hepatitis was characterized by a decrease of isocitrate dehydrogenase, α-ketoglutarate dehydrogenase and malate dehydrogenase activities, while the mitochondrial NAD(+)/NADН ratio remained at the control level. Modeling of acetaminophen-induced hepatitis in rats with alimentary protein caused a more pronounced decrease in the activity of NAD(+)-dependent dehydrogenases studied and a 2.2-fold increase of the mitochondrial NAD(+)/NADН ratio. This suggests that alimentary protein deprivation potentiated drug-induced liver damage.

  18. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Cline, Gary W., E-mail: gary.cline@yale.edu [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States); Pongratz, Rebecca L.; Zhao, Xiaojian [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Papas, Klearchos K. [Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States)

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer We studied media effects on mechanisms of insulin secretion of INS-1 cells. Black-Right-Pointing-Pointer Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. Black-Right-Pointing-Pointer Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. Black-Right-Pointing-Pointer Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with {sup 31}P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by {sup 13}C NMR isotopomer analysis of the fate of [U-{sup 13}C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was found to be congruous with the correlation in KRB. Together, these results suggest that signaling mechanisms associated with both TCA cycle flux and with anaplerotic flux, but not ATP production, may be responsible for the enhanced rates of insulin secretion in more complex, and physiologically-relevant media.

  19. Glycolytic pathway (GP), kreb's cycle (KC), and hexose monophosphate shunt (HMS) activity in myocardial subcellular fractions exposed to cannabinoids

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.T.; Manno, B.R.; King, J.W.; Fowler, M.R.; Dempsey, C.A.; Manno, J.E.

    1986-03-05

    Delta-9-tetrahydrocannabinol (..delta../sup 9/-THC), the primary psychoactive component of marihuana, and its active metabolite 11-hydroxy-..delta../sup 9/-tetrahydrocannabinol (11-OH-..delta../sup 9/-THC) have been reported to produce a direct cardiac depressant effect. Studies in isolated perfused rat hearts have indicated a decreased force of contraction (inotropic response) when ..delta../sup 9/-THC or 11-OH-..delta../sup 9/-THC was administered in microgram amounts. The mechanism and site of action have not been explained or correlated with associated metabolic pathways. The purpose of this study was to investigate the effects of cannabinoids on major myocardial energy producing pathways, GP and KC, and a non-energy producing pathway, HMS. Cardiac ventricular tissue from male Sprague-Dawley rats (250-300 g) was excised and homogenized for subcellular fractionation. KC, GP and HMS activity was assayed in the appropriate fractions by measuring /sup 14/CO/sub 2/ generation from /sup 14/C-2-pyruvate, /sup 14/C-6-glucose and /sup 14/C-1-glucose respectively. Duplicate assays (n=8) were performed on tissue exposed to saline (control), empty liposomes (vehicle) and four doses each of ..delta../sup 9/-THC and 11-OH-..delta../sup 9/-THC. Changes in metabolic activity and decreases in cardiac contractile performance may be associated.

  20. The simplified Federal subject planning procedure with respect to paragraph 11 NABEG; Das vereinfachte Bundesfachplanungsverfahren nach paragraph 11 NABEG

    Energy Technology Data Exchange (ETDEWEB)

    Appel, Markus [Sozietaet Linklaters LLP, Berlin (Germany)

    2013-01-15

    The Act for the Acceleration of Network Expansion (NABEG) transmission network aims a rapid expansion of transnational and cross-border high-voltage performance. This is done in a non-negligible extent in already existing power line routes. For this case, the paragraph 11 of the NABEG contains a special arrangement for the implementation of the necessary federal sector planning regarding to paragraph paragraph 4 NABEG in a simplified procedure. Under this aspect, the author of the contribution under consideration reports on the details of this procedural instrument as well as on issues of practical application.

  1. MR imaging of the knee following cruciate ligament reconstruction and meniscal surgery; MRT des Kniegelenks nach Kreuzband- und Meniskusoperationen

    Energy Technology Data Exchange (ETDEWEB)

    Woertler, K. [Technische Univ. Muenchen, Klinikum rechts der Isar (Germany). Inst. fuer Roentgendiagnostik

    2009-03-15

    Due to the increasing number of surgical procedures performed on the knee, MR imaging of the postoperative knee has gained more and more importance. For the evaluation of anterior cruciate ligament grafts and postoperative menisci, basic knowledge of surgical techniques is essential in order to differentiate normal postoperative findings from transplant failure, retears, and complications. This article reviews technical aspects of MR imaging following knee surgery, basic principles of operative techniques for anterior cruciate ligament reconstruction and therapy of meniscal tears, normal postoperative findings, MR imaging criteria for recurrent lesions, and findings with typical complications. (orig.)

  2. „Und sollte jemand nach mir fragen, sag’, dass ich ihn herzlich grüsse!”

    Directory of Open Access Journals (Sweden)

    Gerd-Dieter Nehring

    2015-09-01

    Full Text Available “And if anyone would ask for me, say I greet him cordially“ The paper overviews as obituary the professional career and work of the known scientist in Albanian and Balkan studies Oda Buchholz (21.01.1940-02.01.2014. It focuses particularly on her publications in the Albanian-German lexicography and grammar drafting as well as on her activities as professor and her cooperation in Germany and abroad. The obit also draws attention to important translations by this scientist and friend of South Eastern Europe.   „Jeśli ktokolwiek spyta o mnie, pozdrówcie go serdecznie” Tekst nekrologu przedstawia drogę naukową i dorobek wybitnej albanolożki i bałkanolożki Ody Buchholz (21.01.1940-2.01.2014.

  3. Histo-morphologische Untersuchungen nach xenogener Transplantation mikroverkapselter Langerhans-Inseln im Modell "Schwein-auf-Ratte"

    OpenAIRE

    Chodnevskaja, Irina

    2006-01-01

    Histo-morphological analyses after xenogeneic Transplantation mikroencap-sulated Islets of Langerhans in the Model „Pig-in-Rat“ Summary The aim of this study was the detailed histological and immunohistochemical analyzation of microencapsulated xenogeneic islet grafts in previously streptozotozin (STZ)-diabetic Wistar WU rats. Microencapsulated porcine islets of Langerhans (mpLI) were transplanted intraperitoneal and under the left renal capsule of these rats without any medical immun...

  4. Health consequences of Chernobyl. 25 years after the reactor catastrophy; Gesundheitliche Folgen von Tschernobyl. 25 Jahre nach der Reaktorkatastrophe

    Energy Technology Data Exchange (ETDEWEB)

    Pflugbeil, Sebastian; Schmitz-Feuerhake, Inge [Gesellschaft fuer Strahlenschutz e.V., Berlin (Germany); Paulitz, Henrik; Claussen, Angelika [Internationale Aerzte fuer die Verhuetung des Atomkrieges, Aerzte in sozialer Verantwortung e.V. (IPPNW), Berlin (Germany). Deutsche Sektion

    2011-04-15

    The report is an evaluation of studies indicating health effects as a consequence of the reactor catastrophe in Chernobyl. The most exposed population include the cleaning personnel (liquidators), the population evacuated from the 30 km zone, the populations in highly contaminated regions in Russia, Belarus and Ukraine, the European population in lass contaminated regions. The following issues are discussed: the liquidators, infant mortality, genetic and teratogenic damages, thyroid carcinoma and other thyroid diseases, carcinogenic diseases and leukemia, other diseases following the Chernobyl catastrophe.

  5. Post Fukushima change of energy policy. German special way or worldwide example?; Energiewende nach Fukushima. Deutscher Sonderweg oder weltweites Vorbild?

    Energy Technology Data Exchange (ETDEWEB)

    Hennicke, Peter; Welfens, Paul J.J.

    2012-07-01

    Based on a critical evaluation of the nuclear power discussion the authors show a reasonable way for nuclear phase-out or change to alternative energy sources. Germany has a historically unique key role to show that a climate protecting energy policy without nuclear power can evolve economic and social advantages, in case the right measures are selected and realized. The Fukushima accidents could trigger a paradigm change for the power industry with a worldwide effect toward industrial ecology and democracy. The worldwide underinsurance of nuclear power plants is a trick to reduce the nuclear power cost. Without subsidization of nuclear power there is no need for subsidization of renewable energy sources.

  6. Chernobyl - 30 years thereafter. Experiences and lessons learned in Austria; 30 Jahre nach Tschernobyl. Erfahrungen und Lehren in Oesterreich

    Energy Technology Data Exchange (ETDEWEB)

    Maringer, Franz Josef [BEV - Bundesamt fuer Eich- und Vermessungswesen, Wien (Austria). Referat fuer ionisierende Strahlung und Radioaktivitaet; Hajek, Michael [Oesterreichischer Verband fuer Strahlenschutz, Wien (Austria). Vienna International Centre; Steger, Ferdinand; Hefner, Alfred

    2016-05-01

    During the severe reactor accident in Chernobyl in 1986 large amounts of radioactive materials have been released to the environment. Unfavorable atmospheric circulation conditions have transported about 2%of the released radioactive matter to Austria. The contribution describes the measures and actions for dose reduction performed in Austria. The measured cs-137 distribution is illustrated (in some areas more the 100 Bq/m2 were deposited). Experiences considering the measurements in consequence of the contamination are discussed and improvements of the emergency planning are summarized.

  7. 30 years after Chernobyl. What would we make better today?; 30 Jahre nach Tschernobyl. Was wuerden wir heute besser machen?

    Energy Technology Data Exchange (ETDEWEB)

    Bieringer, Jacqueline [Bundesamt fuer Strahlenschutz, Freiburg (Germany). Fachgebiet SW 2.5; Hajek, Michael [Oesterreichischer Verband fuer Strahlenschutz, Wien (Austria). Vienna International Centre; Maringer, Franz Josef [BEV - Bundesamt fuer Eich- und Vermessungswesen, Wien (Austria). Referat fuer ionisierende Strahlung und Radioaktivitaet; Murith, Christophe [Bundesamt fuer Gesundheit (BAG), Bern (Switzerland). Abt. Strahlenschutz; Steinkopff, Thomas [Deutscher Wetterdienst, Offenbach (Germany); Wershofen, Herbert [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany). Lab. 6.301; Hefner, Alfred; Maushart, Rupprecht; Steger, Ferdinand

    2016-05-01

    The reactions of the authorities responsible for the measurements of radioactivity in the environment in Germany, Switzerland and Austria ore shown. The further development of the readiness and the possibilities to measure in the last 30 years are described. Also the question of activity measurements after a nuclear accident by single members of the population is dealt with.

  8. Overhead contact lines according to TSI Energy, installation design and technical acceptance; Oberleitungsanlagen nach TSI Energie. Planung und Abnahme

    Energy Technology Data Exchange (ETDEWEB)

    Schnadhorst, Kai [Balfour Beatty Rail GmbH, Essen (Germany); Tessun, Heinz [Balfour Beatty Rail GmbH, Muenchen (Germany)

    2011-04-15

    Comparison of the issues of 2002 and 2008 of the technical specification for interoperability relating to the ''energy'' sub-system of the trans-European high-speed rail system (TSI) influences, especially of the permissible wind deviation to the standard overhead contact line of Deutsche Bahn (DB). Installation design, acceptance, construction and technical approval of an overhead contact line in accordance with TSI. (orig.)

  9. Vergleich relevanter Parameter von Multipixelsensoren für Spurdetektoren nach Bestrahlung mit hohen Proton- und Neutronflüssen

    CERN Document Server

    Bergholz, Matthias; Reif, Jürgen; Husemann, Ulrich

    2016-01-01

    The further increase of the luminosity of the Large Hadron Collider ( LHC ) at CERN requires new sensors for the tracking detector of the Compact Muon Soleniod ( CMS ) experiment. These sensors must be more radiation hard and of a finer granularity to lower the occupancy. In addition the new sensor modules must have a lower material budget and have to be self triggering. Sensor prototypes, the so called “ MPix ”-sensors, produced on different materials were investigated for their radiation hardness. These sensors were fully charac- terized before and after irradiation. Of particular interest was the comparison of different bias methods, different materials and the influence of various geometries. The degeneration rate differs for the different sensor materials. The increase of the dark current of Float-Zone-Silicon is stronger for thicker sensors and less than for Magnetic-Czochralski-Silicon sensors. Both tested bias structures are damaged by the irradiation. The poly silicon resis- tance increases after...

  10. Kurze Halbwertszeit : Geschäftsberichte wirken nicht lange nach - Firmen besinnen sich bei der Information auf den gesunden Menschenverstand

    OpenAIRE

    Gysi, Beat

    2013-01-01

    Artikel von Beat Gysi mit Zitaten von Peter Leibfried: Unternehmen gelangen auf verschiedenen Kanälen an Investoren, Analytiker und Medienleute, aber der Geschäftsbericht bleibt zentral. Die oft aufwendig gestalteten Dokumente werden aber meist rasch weggelegt. Aus der kürzlich durchgeführten Befragung von Investoren, Finanzanalysten und Medienleuten zu den Themen Unternehmensberichterstattung sowie Firmenbewertung wurde die Erkenntnis gewonnen, dass persönliche Gespräche mit dem Mana...

  11. Stimulation of gas wells after workover and completion jobs. Wiederherstellung der Zuflussbedingungen nach Aufwaeltigungs- und Komplettierungsarbeiten in Gasbohrungen

    Energy Technology Data Exchange (ETDEWEB)

    Dietzel, H.J. (Deilmann Erdoel Erdgas GmbH, Lingen/Ems (Germany)); Kleinitz, W. (Deilmann Erdoel Erdgas GmbH, Lingen/Ems (Germany)); Littmann, W. (Deilmann Erdoel Erdgas GmbH, Lingen/Ems (Germany))

    1993-11-01

    Gas wells are often blocked by water after completion and workover jobs. This water block produces a reduction of the flow capacity of the well. The reason for this is a high water saturation and thus a reduction of the effective premeability for gas. This damage can only be reduced very slowly. Introducing surface active substances into the reservoir before and after workover can minimise the impairment. Laboratory measurements were performed to select suitable chemicals for such treatments. A stimulation using Ethyleneglykolmonobuthlether (EGMBE) is given as an example. (orig.)

  12. Die gastrale Dekompression nach Anlage einer großlumigen PEG-Sonde - eine Analyse des Patientenguts der Chirurgischen Klinik

    OpenAIRE

    Wunder, Thomas

    2011-01-01

    Hintergrund und Ziele PEG-Sonden werden weltweit seit nun bereits mehr als 30 Jahren erfolgreich eingesetzt und deren Anlage zählt mit zu den in den Kliniken am häufigsten angewandten Maßnahmen. Sie stellen das Mittel der Wahl zur Aufrechterhaltung der enteralen Ernährung bei Patienten dar, denen aus verschiedensten Gründen die Nahrungsaufnahme über den natürlichen oralen Weg nicht mehr möglich ist, etwa bei Tumor- oder Demenzpatienten. Dass bei der Anwendung und der Anlage nur mit sehr gerin...

  13. Untersuchungen zum Einfluss des Applikationszeitpunkts von Xenon auf die zentralnervoese Leistung von Ratten nach extrakorporaler Zirkulation und zerebralen Luftemboli

    OpenAIRE

    Klemmer, Katja Christina

    2007-01-01

    „Investigations on effects of Xenon application time on cerebral outcome following cardiopulmonary bypass with cerebral air embolism in the rat” Cerebral air embolism (CAE) is thought to be one of the risk factors for adverse cerebral outcome following cardiac surgery with cardiopulmonary bypass (CPB). Neurologic and neurocognitive deficits after cardiac surgery remain a common and severe complication, alleviating patients´ quality of life for years. Providing neuroprotective properties a...

  14. Die Reichweite der Haftungsprivilegien nach dem SGB VII außerhalb des klassischen Arbeitsunfalls / Tobias Matz ; Claudia Baumann

    Index Scriptorium Estoniae

    Matz, Tobias

    2016-01-01

    Ettevõtte ja kollektiivi vastutusest sotsiaalseadustiku § 104 jj tähenduses ebatraditsiooniliste tööõnnetuste korral (nt koolides õpilaste/õpetajate vigastused; praktikandid kutseõppes; loomade tekitatud vigastused jms)

  15. Germanistische Translationswissenschaft in Banská Bystrica : Eine Zwischenbilanz nach fünfzehn Jahren (1997-2012)

    OpenAIRE

    Bohušová, Zuzana

    2012-01-01

    Im Jahr 2012 feiert die Matej-Bel-Universität in Banská Bystrica ihr zwanzigjähriges Bestehen. Zugleich sind an dieser Universität 15 Jahre lebendiger translationswissenschaftlicher Bemühungen in Lehre und Forschung zu verzeichnen. Ein Jahr zuvor, 2011, konnte auch der SUNG – der Verband der Deutschlehrer und Germanisten der Slowakei – auf zwanzig Jahre ergiebiger Tätigkeit zurückblicken. In diesem Jahr schließe auch ich mit 20 Jahren Tätigkeit in der slowakischen Germanistik als Pädagogin an...

  16. Ein realer Lernort mit digitalem Mehrwert. Die Bibliothek der Universität Konstanz nach der Sanierung

    Directory of Open Access Journals (Sweden)

    Oliver Kohl-Frey

    2014-12-01

    Full Text Available Die Sanierung der Bibliothek der Universität Konstanz erforderte eine Überprüfung des bibliothekarischen Konzepts aus den sechziger Jahren, das in einem Gebäude der siebziger Jahre umgesetzt wurde. Insgesamt betrachtet bewährt sich das Konzept der Konstanzer Bibliothek bis heute, und es werden lediglich Anpassungen an die Bedürfnisse des 21. Jahrhunderts nötig. Durch aktive Pflege des gedruckten Bestands inklusive Aussonderung konnte Raum für die notwendige Ausweitung der Funktionen als Lernort und als sozialer Ort geschaffen werden. Das neu konzipierte Hybrid Bookshelf erlaubt eine neuartige Präsentation des digitalen Bestands am Ort Bibliothek. Durch die so angepasste Konzeption kann eine signifikante Aufwertung des realen Lernorts samt digitalem Mehrwert erreicht werden. The redevelopment process of the University of Konstanz Library required a proof of the sixties library concept that was realized within a seventies building. Generally the concept has proved itself; small adaptions have to be realized for the needs of the 21.century. The libraries functions as learning space and as social space are strengthened. Through the newly developed Hybrid Bookshelf the digital collection will be visible within the library space. That leads to a significant appreciation of the real learning space and a digital additional value.

  17. Berührt sein – Ein Fallbericht zur Rolle von WATSU (WasserShiatsu) in der Rehabilitation nach Polytrauma

    OpenAIRE

    Schitter, Agnes Maria; Fleckenstein, Johannes

    2017-01-01

    Hintergrund: Die herausragende Bedeutung von Körperkontakt für den Menschen ist bekannt und nachgewiesen. Während aber intensiver Körperkontakt in der medizinischen Versorgung von Frühgeborenen etabliert ist, wird Berührung in schulmedizinische Therapiekonzepte für Erwachsene bisher nur marginal integriert. Massnahmen aus der Komplementärmedizin berücksichtigen den individuellen Bedarf an körperlicher Nähe und leisten einen klinischen Mehrwert für den Gesundungsprozess. In besonderer Weise...

  18. Vergleich der Wirksamkeit von Physiotherapie, apparativem Kontinenztraining und Ganzkörpervibration zur Behandlung der Inkontinenz nach radikaler Prostatektomie

    Directory of Open Access Journals (Sweden)

    Zeller M

    2012-01-01

    Full Text Available Trotz Verbesserung der Neuroprotektion bei radikaler Prostatektomie kommt es dennoch häufig zu subjektiv belastenden Störungen der (Früh- Kontinenz. Als kausale Therapie in der Hand des qualifizierten Therapeuten anerkannt ist die qualifizierte Physiotherapie. In einer offenen, randomisierten, kontrollierten Studie wurde die Effizienz einer standardisierten Rehabilitationsbehandlung mit physiotherapeutischem Kontinenztraining bei einer Kontrollgruppe (n = 25 mit einem zusätzlichen apparativen Training (Myo 420®; kombinierte Elektrostimulation und apparatives Biofeedback (n = 25 und mit Ganzkörpervibration (FitVibe medical® (n = 25 verglichen. Prä- und posttherapeutisch ausgewertet wurden IPSS, IPSS-LQ, Pad-Test, Beckenbodenspannung, maximale Harnflussrate, Miktionsvolumen, Serumtestosteron und Blutzuckerspiegel. Innerhalb der Behandlungsdauer von 3–4 Wochen kam es in allen 3 Gruppen zu einer statistisch signifikanten Verbesserung von IPSS und IPSS-LQ. Für die Gruppe mit Ganzkörpervibration waren die Ergebnisse für die Reduktion des Urinverlustes (Pad-Test sowie für die Zunahme des Miktionsvolumens und der maximalen Harnflussrate statistisch signifikant. Während sich für die isolierte Physiotherapie innerhalb der kurzen Behandlungsdauer lediglich ein Trend für die Verbesserung der Beckenbodenkraft nachweisen ließ, war der Unterschied für beide apparative Behandlungsgruppen statistisch signifikant. Dadurch wird deutlich, dass für eine kontinuierliche Verbesserung der Kontinenz und einen nachhaltigen Therapieerfolg die konsequente Fortsetzung des Trainings auch unter häuslichen Bedingungen entscheidend ist. Unter kontrollierten Bedingungen konnten die Wirksamkeit, Akzeptanz und Verträglichkeit eines standardisierten Kontinenztrainings unter den Bedingungen einer stationären urologischen Rehabilitation bestätigt werden. Eine weitere Effizienzsteigerung kann durch den zusätzlichen Einsatz einer kombinierten Elektro- und mehrkanaligen Biofeedbackbehandlung oder einer Ganzkörpervibration erreicht werden. Aufgrund der unterschiedlichen kausalen therapeutischen Ansätze und Wirkungen sollte der Frage einer weiteren Therapieoptimierung durch die Kombination aller 3 Behandlungskomponenten im Rahmen einer kontrollierten Studie nachgegangen werden.

  19. Untersuchungen an Plattfischen und Nordseegarnelen (Crangon crangon) im Eulitoral des Wattenmeeres nach dem Übergang zum Bodenleben

    Science.gov (United States)

    Berghahn, R.

    1983-06-01

    In spring and early summer, Pleuronectes platessa, Platichthys flesus, Solea solea, and Crangon crangon transform to benthic postlarvae in the shallow water region of the North Frisian Wadden Sea (eastern North Sea). During the first weeks after metamorphosis, they remain in the puddles and drainage gulleys on the tidal flats that are exposed during low tide. Positive rheotaxis prompting the juveniles to swim against the ebb tide currents is an important mechanism for maintaining their position on the flats. When sunlight intensity increases, they continue their locomotory and feeding activity, even during daytime, in the pools still present at low tide. On warm, cloudless days, temperature levels in these pools may increase to lethal thresholds. Consequently, the animals attempt to escape from higher tidal flats near the shore through the drainage gulleys. Such migrations bring about changes in their distribution patterns. Plaice can scarcely be found in near-shore areas, and they are absent at both high and low tide. The responses observed were correlated to physical and chemical data recorded during the observation period. The ecological significance of tidal pools as habitats is discussed.

  20. Automation of an energy-autarkic manufacturing plant following IEC 61499; Automatisierung einer energieautarken Fertigungsanlage nach IEC 61499

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Christian; Hirsch, Martin; Hanisch, Hans-Michael [Halle-Wittenberg Univ., Halle (Saale) (Germany). Lehrstuhl Automatisierungstechnik

    2009-07-01

    The requirements for future manufacturing plants are, beyond others, seamless reconfiguration, autonomy as far as possible as well as easy employment and maintenance for the end user. Within the EnAS project (Energy-Autarkic Actuators and Sensors), the group of the Automation Technology Lab in Halle has challenged the fulfillment of those requirements. Therefore, IEC 61499 compliant distributed controllers have been developed for the demonstrator-plant under particular consideration of reconfigurability. These controllers have been integrated into the process sequences of the demonstrator and afterwards several reconfiguration scenarios have been designed. The building of a Human-Machine-Interface for visualization and reconfiguration of the plant was an essential issue as well. The result is a highly flexible, easily reconfigurable system, which can be regarded as a prototype for automated manufacturing plants of a new generation. (orig.)

  1. IT-Compliance nach COBIT: Gegenüberstellung zwischen COBIT 4.0 und COBIT 5

    OpenAIRE

    Klotz, Michael

    2014-01-01

    Mit der aktuellen fünften Version (COBIT 5) wurden grundlegende Erweiterungen und Änderungen des COBIT-Frameworks vorgenommen. Inwieweit sich dies auf das IT-Compliance-Verständnis und das Management von IT-Compliance ausgewirkt hat, wird in diesem Arbeitspapier untersucht. Hierzu werden die vierte und die fünfte Version von COBIT auf ihre compliance-relevanten Aussagen hin untersucht und vergleichend gegenübergestellt. Im Ergebnis weist COBIT 4.0 in seiner Struktur zahlreiche Inkonsistenzen ...

  2. CT and ultrasound normal findings after laparoscopic surgery of inguinal hernia; CT- und Ultraschallnormalbefunde nach laparoskopischer Leistenhernienoperation

    Energy Technology Data Exchange (ETDEWEB)

    Hergan, K. [Zentrales Inst. fuer Radiologie, LKH Feldkirch (Austria); Scheyer, M. [Abt. fuer Chirurgie, LKH Feldkirch (Austria); Oser, W. [Zentrales Inst. fuer Radiologie, LKH Feldkirch (Austria); Zimmermann, G. [Abt. fuer Chirurgie, LKH Feldkirch (Austria)

    1995-01-01

    Common surgery has been revolutionised by minimal invasive surgery in a very short period of time. Laparoscopic operations of inguinal hernias are routinely done by many surgeons. For interpreting correctly postoperative complications with radiological techniques it is necessary to know the sonographical and CT changes of the normal postoperative situs. For evaluating these changes 23 patients without symptoms were examined between the first and third postoperative day. Typical sonographic findings are high echogenicity of the hernial orifice (17x) and echolucent thickening of the spermatic cord. The surgical clips and fleece and CO{sub 2} bubbles could not be detected by ultrasound. Using CT we found free peritoneal fluid collection (2x), streaky thickenings in the area of operation (20x), oedema at the hernial orifice (19x), residual CO{sub 2} bubbles (22x), thickening of the spermatic cord (22x) and visualisation of the surgical clips. The surgical fleece was invisible in all patients. (orig.) [Deutsch] Die minimal invasive Chirurgie hat in kurzer Zeit die Allgemeinchirurgie revolutioniert. Die laparoskopische Leistenhernienoperation gehoert bereits zur taeglichen Routine. Postoperative Komplikationen lassen sich mit bildgebenden Verfahren nur richtig interpretieren, wenn sonographische und computertomographische Veraenderungen des normalen postoperativen Situs bekannt sind. Zur Erfassung dieser Veraenderungen wurden 23 asymptomatische Patienten zwischen erstem und drittem postoperativen Tag mittels Sonographie und CT untersucht. Typische sonographische Befunde sind vermehrte Echogenitaet der Bruchpforte (17mal) und echoarme Verdickung des Funiculus spermaticus (21mal) bei fehlender Abgrenzung von Operationsklammern und -vlies sowie residualer CO{sub 2}-Blaeschen. Mittels CT fand man freie, peritoneale Fluessigkeit (2mal), Verdichtungen im Operationsbereich (20mal), Oedembildungen in der Bruchpforte (19mal), residuale CO{sub 2}-Blaeschen (22mal), hypodense Verdickung des Funiculus spermaticus (22mal) sowie Darstellung der Operationsklammern bei fehlender Abbildung des Operationsvlieses bei allen Patienten. (orig.)

  3. Radiological study of ileum neobladder after radical cystoprostatectomy. Radiologische Untersuchung der Ileum-Neoblase nach radikaler Zystoprostatektomie

    Energy Technology Data Exchange (ETDEWEB)

    Schumacher, K.A.; Bader, C.; Weidenmaier, W. (Ulm Univ. (Germany, F.R.). Radiologische Klinik und Poliklinik); Gschwend, J. (Ulm Univ. (Germany, F.R.). Urologische Klinik)

    1991-05-01

    The study reports on radiographic findings obtained from 70 male patients in whom, following radical cystoprostatectomy for carcinoma, an ileum neobladder was created. Morphological appearance and postoperative complications of this continent type of bladder replacement were documented by means of cystography, excretory urography, retrograde urethrography and CT. Specific complications rarely arose from suture insufficiencies of the neobladder itself (n=3) or from the ileourethral anastomosis (n=2). Stenoses coccurred at the site of the ileourethral (n=9) and the ureteroileal anastomosis (n=2). Transient dilatation of the upper urinary tract was observed in the majority of patients. Non-specific complications included pelvic absceses (n=2), haematomas (n=2), lymphoceles (n=3), and ileus (n=2). (orig.).

  4. Faster to Paris with Franco-German cooperation; Schneller nach Paris mit ICE und TGV in deutsch-franzoesischer Kooperation

    Energy Technology Data Exchange (ETDEWEB)

    Ried, W.M. [ALLEO GmbH i.Gr. (Joint Venture DB/SNCF im HGV) (Germany)

    2007-06-15

    A new railway line for high-speed operations on a European scale has been completed in only five years. In parallel with that, a big effort has been put into national and international coordination of what train services to offer. (orig.)

  5. Clinical 3-year follow-up of uterine fibroid embolization; Klinische 3-Jahres-Ergebnisse nach Uterusmyomembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Radeleff, B.A.; Satzl, S.; Eiers, M.; Fechtner, K.; Hakim, A.; Kauffmann, G.W.; Richter, G.M. [Universitaetsklinikum Heidelberg (Germany). Abt. Radiodiagnostik; Rimbach, S. [Klinikum Konstanz (Germany). Frauenklinik

    2007-06-15

    Purpose: The purpose of this study was to evaluate the clinical long-term success of uterine artery embolization (UAE) in patients with symptomatic fibroids using spherical particles (Embosphere). Materials and Methods: 34 consecutive patients treated with UAE were initially enrolled in the study which had the following study goals (1) 1-year follow-up MRI evaluation of the fibroid behavior and (2) clinical long-term success due to standardized assessment of the main fibroid-related symptoms (hypermenorrhoea, dysmenorrhoea and dysuria) of the patients' individual overall health status and their therapy satisfaction at 1-year, 2- year and 3-year intervals after UAE. Results: Technical success was achieved in all procedures. Four patients had to be excluded from the long-term evaluation schedule: one because of a hysterectomy due to bleeding after 6 weeks, 3 patients were not available for the designated minimum follow-up interval. The preinterventional severe hypermenorrhoea (n = 27) with a score of 4.4 {+-} 0.7 (5 = extreme menstrual bleeding) decreased after one year to 2.1 {+-} 0.5 (p = 0.0001), after two years to 1.7 {+-} 0.5 (p = 0.0042) and after three years to 1.3 {+-} 0.6 (p = 0.0001). The preinterventional dysmenorrhoea (n = 15) with a score of 3.1 {+-} 1.5 (3 = distinctly increased dysmenorrhoea) decreased after one year to 1.1 {+-} 0.3 (p = 0.0001), after two years to 1.2 {+-} 0.2 and after three years to 1.2 {+-} 0.4 (p = 0.148). The pretreatment dysuria (n = 12) with a preinterventional score of 3.1 {+-} 1.5 (3 = distinctly increased dysuria) decreased after one year to 1.1 {+-} 0.3 (p = 0.0069) and remained after two years at 1.1 {+-} 0.2 and after three years at 1.2 {+-} 0.4 (p = 0.905). The initial overall health status was 54.7 {+-} 20.1 (maximal value 100). After one year it rose to 90.5 {+-} 15.4 (p = 0.0001), was 91.8 {+-} 5.6 after two years and was 91.3 {+-} 8.5 (p = 0.8578) after three years. The satisfaction with the therapy was 2.9 {+-} 0.2 after one year, 2.6 {+-} 0.3 after two years and 2.7 {+-} 0.5 (3 = extremely satisfied) after three years. We observed 12 minor and 3 major complications (one hysterectomy, one fibroid expulsion associated with a short bleeding episode and one transient amenorrhoea for three months). All patients benefited clinically from the procedure and a clinical benefit was achieved in all cases. (orig.)

  6. Rezension von: Julia Obertreis, Anke Stephan (Hg.: Erinnerungen nach der Wende. Oral History und (postsozialistische Gesellschaften. Essen: Klartext Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Sabine Kittel

    2011-01-01

    Full Text Available Im Sammelband wird eine breite Palette von Forschungen zu Postsozialismus und biographischen Erinnerungen an die sozialistische Vergangenheit vorgestellt. Autorinnen und Autoren aus zwölf Ländern diskutieren laufende oder gerade abgeschlossene Dissertationsprojekte, die alle auf Oral-History-Interviews basieren. Indem die Erinnerungen der Menschen Ausgangspunkt der Betrachtung sind, gelingt es in dem Band, unterschiedlichste Lebenswelten und individuelle Umgangsweisen mit der vergangenen sozialistischen Welt und die fortdauernde Aushandlung verschiedener Versionen von Vergangenheitsdeutung in Südost- und Mitteleuropa vorzustellen. Die Sammlung der vielfältigen Erfahrungshorizonte von Frauen und Männern, Alten und Jungen, ehemaligen Opfern und heutigen Aktivist/-innen stellt eine Systematisierung der Erkenntnisse allerdings vor Probleme: Können, sollen oder müssen Erinnerungs- oder Erfahrungsmuster von Frauen in einem eigenen Kapitel diskutiert werden?

  7. Strömungsuntersuchung in Modellen humaner Karotisbifurkationen nach Stentimplantation mittels Laser-Doppler-Anemometrie und endoluminaler Doppler-Sonographie

    OpenAIRE

    Greil, Oliver

    2007-01-01

    Ziel: Der Stentangioplastie der Karotisstenose kommt zunehmende klinische Bedeutung zu. Unter experimentellen Bedingungen wurde der Einfluß verschieden positionierter Stents auf das Strömungsverhalten in einem physiologischen Modell der A.carotis getestet. Material und Methoden: In maßstabsgetreue Silikonmodelle der A.carotis wurden Wallstents (Boston Co.) implantiert. Folgende Positionen wurden simuliert: Stentposition exakt in der ACI, am Bulbus, den Bulbus überbrückend und den Bulbus teilw...

  8. Bodenüberwachung nach der Umstellung des Guts Rheinau auf biologische Bewirtschaftung - Berichtsperiode 1999-2010

    OpenAIRE

    Mäder, Paul; Pfiffner, Lukas; Fließbach, Andreas

    2011-01-01

    Mit der Umstellung des Gutes Rheinau von konventionell integrierter Bewirtschaftung auf bio-dynamische Wirtschaftsweise im Jahre 1998 wurde ein Monitoring der Bodenfruchtbarkeit begonnen, dass die biologische Veränderung im Boden während der Umstellungsphase dokumentieren sollte. Die ersten Bodenproben wurden 1999 auf drei Ackerschlägen und einer permanenten Naturwiese gezogen und dann wurden im Jahr 2002, 2005 und 2010 auf den in 1999 definierten Teilflächen je Schlag weitere Bodenproben ent...

  9. NMR imaging in follow-up checks on semitendinous cruciate ligament reconstructions. Kernspintomographische Kontrolluntersuchungen nach Semitendinosus-Kreuzbandplastiken

    Energy Technology Data Exchange (ETDEWEB)

    Schedel, H. (Strahlenklinik und Poliklinik, Freie Univ. Berlin, Klinikum Rudolf Virchow (Germany)); Steger, W. (Strahlenklinik und Poliklinik, Freie Univ. Berlin, Klinikum Rudolf Virchow (Germany)); Zellner, A. (Orthopaedische Klinik und Poliklinik, Freie Univ. Berlin, Klinikum Steglitz (Germany)); Dihlmann, S. (Orthopaedische Klinik und Poliklinik, Freie Univ. Berlin, Klinikum Steglitz (Germany)); Mueller, F. (Strahlenklinik und Poliklinik, Freie Univ. Berlin, Klinikum Rudolf Virchow (Germany)); Oellinger, H. (Strahlenklinik und Poliklinik, Freie Univ. Berlin, Klinikum Rudolf Virchow (Germany)); Felix, R. (Strahlenklinik und Poliklinik, Freie Univ. Berlin, Klinikum Rudolf Virchow (Germany))

    1993-12-01

    Ten patients previously subjected to reconstructive surgery of the semitendinous crucial ligaments were in each case investigated after six and twelve months using the method of nmr imaging. The patients invariably reported to be free from pain and showed a range of motion of at least 0/0/120 degrees. Without exception, they scored negative on Lachmann's test. T1-weighted measurements of the repaired ligaments revealed variations in thickness from 4 mm to 9 mm. Increased contrast medium densities of the graft were observed for two patients, in whom a fat-suppressed sequence had additionally suggested the presence of unusual changes in the spongy tissue of the femural condyle and on the proximal tibial surface. These two patients and a further participant were also shown to have hydrarthrosis on the basis of a T2-weighted spin echo sequence. Within a year of surgery, atrophic changes to the semitendinous muscle were seen in all the patients examined here. The method of nmr imaging, in particular when used in combination with gd dtpa as contrast medium, permits to follow-up the course of healing after reconstructive surgery of the semitendinous cruciate ligament and promptly reveals the presence of impingement or any other insufficiencies of the graft. (orig./UWA)

  10. New media and their influence on the reporting after Fukushima; Neue Medien und ihr Einfluss auf die Berichterstattung nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Hampel, Gabriele [Axpo Power AG, Doettingen (Switzerland). Kernkraftwerk Beznau; Stieghorst, Christian [Mainz Univ. (Germany). Inst. fuer Kernchemie

    2014-10-01

    Subsequent to a comparison of classic conventional media with the new globalized 'Social Media' and their chances and risks it is dealt with the influence of the new media on the coverage of the Fukushima event. In particular, the difficulties of a serious reporting caused by the more and more pronounced lack of specialized journalists and of the usual specialized scientific terminology are pointed out. (orig.)

  11. PHILOSOPHIE(GESCHICHTE AUF GRUNDLAGE VON GAARDERS «SOFIES WELT» IM DAF-SACHUNTERRICHT NACH LDL

    Directory of Open Access Journals (Sweden)

    Guido Oebel

    2011-11-01

    Full Text Available : Thoroughly positive experience previously gained from both philosophical and issues of philosophical history in social study classes (cf. Hengelbrock 1991a; b; c; 1992; Heller 1994 convinced the author to even go beyond that by implementing Jostein Gaarder’s project idea “Sophie’s World” in a kind of special classroom of German as foreign language (cf. Oebel 2005a; b; c; 2007. In this context, Jean-Pol Martin’s “holistic approach” (Abendroth-Timmer LdL (“Learning-by-Teaching” for German “Lernen-durch-Lehren” seems to be the probably most emphatic constructivistic project teaching method (cf. Scheelhaas 1997; 2003; Wolff 2002, a fact that it has already proved impressively and sustainably not only in the follow-up project presently described but on several other occasions.

  12. Sustainable hydropower - 10 years after WCD; Nachhaltige Wasserkraftnutzung. Wo stehen wir 10 Jahre nach Erscheinen der WCD-Empfehlungen?

    Energy Technology Data Exchange (ETDEWEB)

    Seeger, Cathleen [Deutsche Gesellschaft fuer Technische Zusammenarbeit GmbH (GTZ), Eschborn (Germany)

    2010-07-01

    After long discussion around and following the recommendations of the World Commission on Dams (WCD), large dams are back on the agenda of International Finance Institutions and developing countries with high hydropower potential. German Development Cooperation endorsed and implements the guidelines of the WCD. The objective of the article is to illustrate the role German Development Cooperation play within the dam debate 10 years after WCD. On the basis of two examples, the Ghana Dam Dialogue (GDD) and the contribution to the Hydropower Sustainable Assessment Forum (HSAF), the objectives and motivations are shown. (orig.)

  13. Vaterschaft nach der Scheidung – Die Perspektive der Väter Fatherhood After Divorce—The Fathers’ Perspective

    Directory of Open Access Journals (Sweden)

    Michael Matzner

    2004-11-01

    Full Text Available Während man in Deutschland die Situation von allein erziehenden Müttern gut erforscht hat, wandte man sich den von ihren Kindern getrennt lebenden Vätern nur äußerst selten zu. Dies ist mehr als erstaunlich, wenn man sich die in die Millionen gehende Zahl betroffener Väter und Kinder vor Augen führt. Allein im Jahr 2000 wurden 95.000 Ehepaare mit minderjährigen Kindern (146.000 geschieden. Bei Gerhard Amendts empirischer Studie handelt es sich um die erste deutschsprachige, als Buch erschienene wissenschaftliche Veröffentlichung zum Thema „Scheidungsväter“. Amendt beantwortet aus der Perspektive der Väter folgende Fragen: Wie sprechen Väter über ihre Scheidung und wie gehen sie mit den Scheidungsfolgen um? Wie verbringen sie die Zeit mit ihren Kindern? Warum brechen manche von ihnen den Kontakt zu den Kindern ab? Der neue Zugang zum Thema Scheidung bzw. Trennung über die Person des Vaters war längst überfällig und bringt neue Perspektiven und Erkenntnisse in die wissenschaftliche Debatte.While the situation of single mothers has been duly researched in Germany, very rarely has attention been given to fathers who live separated from their children. This is truly remarkable when one surveys the number, rising into the millions, of fathers and children affected. In the year 2000 alone, 95,000 married couples with dependant children (146,000 divorced. Gerhard Amendt’s empirical study can be seen as the first German-language, book length, scientific publication on “divorced fathers.” Arendt answers the following questions from the perspective of the fathers: How do fathers talk about divorce and how do they deal with the consequences of divorce? How do they spend time with their children? Why do some of them cut off contact to their children? This new access to the issues of divorce or separation with regard to the father was long overdue and brings new perspectives and realizations to the scientific debate.

  14. Periprothetische Femurfrakturen nach Hüftgelenksersatz: Rationale für die intra- oder extramedulläre Behandlung

    DEFF Research Database (Denmark)

    Haag, C.; Seif El Nasr, M.; Schmal, H.

    2000-01-01

    In our institution from 1991 to 1998 48 patients (32 women and 16 men) were treated for periprosthetic fractures of the femur following total hip arthroplasty (THA). A fracture of the femur was found in 47 cases, and once the acetabulum was fractured. The average age was 80.2 years, and the average...... periprosthetic fractures. The periacetabular fracture was treated by replacement of the socket. The periprosthetic femoral fractures were classified after Whittaker [19]. 2 of 47 patients were not able to tolerate an anesthesia because of cardiac and pulmonary malfunctions. Of the remaining 45, 2 patients were...... of an occurring periprosthetic fracture. The region around the tip of the prosthesis is particularly endangered to undergo a fracture in case of an impact. After the replacement of a prosthesis, older patients benefit from early mobility and exercise....

  15. Das Sächsische Blaufarbenwesen und der Handel mit Kobaltfarben – nach Unterlagen der Bücherei der Bergakademie Freiberg

    NARCIS (Netherlands)

    Hammer, P.

    2004-01-01

    The German word ‘Kobold’ is the term for gnomes and goblins. It appeared for the first time in connection with minerals in Agricola’s Bermannus (1530). The first practical use was in the form of zaffer or cobalt-blue. Zaffer will not melt alone, but accompanied by vitreous substances it melts into

  16. Eine 22-jährige Mutter mit starkem Juckreiz und zunehmendem Ikterus zwei Wochen nach Beginn der hormonalen Kontrazeption

    NARCIS (Netherlands)

    Guth, C.; Beuers, U.; BECKH, K.

    2016-01-01

    Intermittent cholestatic liver disease may indicate an inherited deficiency of bile salt transport proteins. Episodes of cholestasis may start during pregnancy or during use of oral contraceptives or other medication. We describe the case of a 22-year-old mother with increasing jaundice and severe

  17. Infektionen bei Neutropenie nach Chemotherapie in den Jahren von 1996 bis 2003 am Klinikum Mutterhaus der Borromäerinnen

    OpenAIRE

    Eckhardt, Markus

    2008-01-01

    Es wurden insgesamt 96 Patienten mit einem Durchschnittsalter von 51,34 Jahren und einer durchschnittlichen Aplasiedauer von 13,44 Tagen bei insgesamt 184 Chemotherapiezyklen untersucht. Es konnte gezeigt werden, dass in unserer Klinik v.a. Hochrisikopatienten therapiert wurden. Ein wesentliches Ergebnis der Arbeit ist, dass die Dauer der Aplasie der wesentliche Risikofaktor sowohl für das Risiko ist, eine Infektion zu erleiden, als auch für das Risiko zu sterben. Es hat sich gezeigt, dass mi...

  18. Commercial building to low energy standards. Crucial decisions at building shell; Geschaeftsbau nach Passivhaus-Standard. Entscheidende Weichenstellungen beim Rohbau

    Energy Technology Data Exchange (ETDEWEB)

    Brenckle, R.

    2007-07-01

    This article describes the Customer Care Centre of the IWB utility in Basel, Switzerland, which was built to the Minergie-P extremely low energy consumption standard. In particular, the importance of crucial decisions made before the start of the construction of the building's shell is stressed. The optimal co-ordination of statics, insulation and permeability is discussed, as are aspects concerning the positioning of windows, waste-heat recovery and air-conditioning. The project and its background are discussed. The heating and ventilation concept, heat gains and losses and the associated ideas used in the building are looked at in detail.

  19. Gesa Anne Busche: Über-Leben nach Folter und Flucht. Resilienz kurdischer Frauen in Deutschland. Bielefeld: transcript Verlag 2013.

    Directory of Open Access Journals (Sweden)

    Heinz-Jürgen Voß

    2013-10-01

    Full Text Available Die Asylbedingungen in der Bundesrepublik Deutschland sind für Menschen, die vor Verfolgung und Folter fliehen mussten, problematisch und teilweise lebensbedrohlich. Traumatisierungen werden nicht oder unzureichend behandelt und durch die Asylbedingungen häufig noch verstärkt. Gesa Anne Busche befragte vier kurdische Frauen, die vor Verfolgung und Folter in der Türkei geflohen sind und in der Bundesrepublik Asyl suchten. Sie gewährt mit ihrem Buch einen Zugang, der jedoch fundierter und näher an der Perspektive der interviewten Frauen hätte sein müssen. Ihre eigenen Vorannahmen hätten im Forschungsprozess aktiv und unter anderem auf Grundlage von Arbeiten von Frauen of Color reflektiert werden können – dass das nicht geschehen ist, schmälert den Ertrag des Buches deutlich.The conditions for asylum in the Federal Republic of Germany are problematic and in parts even life-threatening for people, who had to flee from persecution and torture. Traumatizations are not or insufficiently treated and often even intensified through the conditions for asylum. Gesa Anne Busche interviewed four Kurdish women, who fled from persecution and torture in Turkey and sought asylum in Germany. Her book offers an approach, which should, however, have been closer to the perspective of the interviewed women. During the research process, her own presuppositions could have been reflected on, among others, based on works by Women of Color – the fact that this was not done reduces the book’s benefit considerably.

  20. Renal artery stenosis after radiotherapy for Ewing's sarcoma; Radiotherapieinduzierte Nierenarterienstenose nach Behandlung eines Ewing-Sarkoms

    Energy Technology Data Exchange (ETDEWEB)

    Tacconi, S.; Bieri, S. [Abt. fuer Radioonkologie, Centre Hospitalier du Centre du Valais (CHCVs), Hopital de Sion (Switzerland)

    2008-09-15

    Background: the fact that therapeutic irradiation can induce significant stenosis in the arteries of the head, neck, and chest, as welt as in the aorta and the iliac arteries, is familiar in daily practice and well documented in the literature. By contrast, radiation-induced renal artery stenosis seems to be a less widely known complication. Patients and methods: the sudden onset of medically refractory arterial hypertension and coma in a 27-year-old man is reported, who had been treated at age 20 with chemotherapy and radiotherapy for Ewing's sarcoma in the lumbar region. This treatment had been performed at the hospital of Sion, Switzerland in 2001. Also, the relevant literature from 1965 to 2007 is reviewed to underscore various aspects of this problem and to demonstrate the clinical relevance of renal artery stenosis as a potential long-term sequela of radiotherapy. Conclusion: radiation-induced renal artery stenosis has only rarely been described in the literature, but arterial hypertension due to radiation-induced renal artery stenosis is a serious long-term sequela that can appear at a latency of up to 20 years after treatment. The paucity of reports presumably reflects the lesser frequency of radiotherapy for retroperitoneal tumors as compared to head-and-neck cancers, as well as lower awareness of the problem due to diagnostic bias in the era before CT and MRI were in routine use: at that time, carotid artery stenosis was easy to diagnose by ultrasonography, while radiation-induced renal artery stenosis, whose real incidence may well be higher, probably often went undetected. Thus, when a patient with a history of abdominal or retroperitoneal radiotherapy unexpectedly develops intractable hypertension, radiation-induced renal artery stenosis must be included in the differential diagnosis. (orig.)

  1. Early loss of teeth after treatment for childhood leukemia; Fruehzeitiger Zahnverlust nach Leukaemiebehandlung im Kindesalter. Fallbericht und Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, T.; Doerr, W.; Lesche, A.; Lehmann, D. [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Medizinische Fakultaet der Technischen Univ. Dresden (Germany); Koy, S. [Klinik und Poliklinik fuer Mund-, Kiefer- und Gesichtschirurgie, Medizinische Fakultaet der Technischen Univ. Dresden (Germany)

    2004-06-01

    Background: only few reports of effects of radiotherapy in childhood on the dental apparatus are available in the literature. The basis for early loss of teeth appears to be a reduction of the root surface area after radiation exposure. These effects in the periodontium are a consequence of combined radiochemotherapy usually applied for treatment of childhood neoplasia. Chemotherapy alone also results in changes of periodontal development. Case report: a 33-year-old patient is reported, who, at the age of 11 years, received high-dose chemotherapy and radiotherapy of neuroaxis and cranium for acute lymphatic leukemia with relapse. The patient consulted the Implant Section of the Department of Oral and Maxillofacial Surgery because of severe dental changes and tooth loss despite adequate dental care and oral hygiene. Radiation doses given to the superior maxilla and mandible at the age of 11 were estimated to be in the range of 8-25 Gy. Conclusion: intense, life-long dental care and follow-up of patients cured from malignant disease in childhood must hence be postulated in order to minimize dental treatment sequelae by supportive measures, but also to initiate timely adequate dental and prosthetic management. (orig.)

  2. Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Mukai, Y.; Hata, M.; Koike, I.; Inoue, T. [Yokohama City University Graduate School of Medicine, Department of Radiology, Kanazawa-ku, Yokohama, Kanagawa (Japan); Mitsudo, K.; Koizumi, T.; Oguri, S.; Kioi, M.; Tohnai, I. [Yokohama City University Graduate School of Medicine, Department of Oral and Maxillofacial Surgery, Yokohama, Kanagawa (Japan); Omura, M. [Shonankamakura General Hospital, Department of Radiation Oncology, Kamakura, Kanagawa (Japan)

    2014-02-15

    Docetaxel. Die Tumore wurden mit einer durchschnittlichen Gesamtdosis von 60 Gy in 30 Fraktionen bestrahlt. Eine komplette Remission (CR) wurde bei 29 der 34 Patienten (85 %) erzielt; 5 Patienten hatten Resttumore. Von den 29 Patienten mit einer CR wiesen 2 Patienten lokale Rezidive und 1 Patient 1-15 Monate nach der Behandlung Fernmetastasen auf. Nach einer durchschnittlichen Beobachtungszeit von 36 Monaten (12-79 Monate) hatten 26 der 36 Patienten ueberlebt; 4 Patienten verstarben an Krebs und 4 verstarben an anderen, nicht krebsbezogenen Ursachen. Sowohl 3 und 5 Jahre nach der Behandlung betrug die Gesamtueberlebensrate 79 % und die ursachenspezifische Ueberlebensrate 85 %. Eine Osteoradionekrose des Unterkiefers trat nach der Behandlung bei 1 Patienten auf. Die Strahlenbehandlung mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie war effektiv und sicher bei der Behandlung des Gingivakarzinoms. Diese Therapie kann eine vielversprechende, heilende und organsparende Behandlungsmoeglichkeit fuer Gingivakarzinome darstellen. (orig.)

  3. Craniocerebral trauma. Magnetic resonance imaging of diffuse axonal injury; Schaedel-Hirn-Trauma. MRT bei diffuser axonaler Verletzung

    Energy Technology Data Exchange (ETDEWEB)

    Mallouhi, A. [Medizinische Universitaet Wien, Allgemeines Krankenhaus, Abteilung fuer Neuro- und Muskuloskelettale Radiologie, Klinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-09-15

    Acceleration-deceleration rotational brain trauma is a common cause of disability or death in young adults and often leads to a focal destruction of axons. The resulting pathology, axonal shear injury is referred to as diffuse axonal injury (DAI). The DAI-associated lesions occur bilaterally, are widely dispersed and have been observed in the surface and deep white matter. They are found near to and far from the impact site. When DAI is clinically suspected, magnetic resonance imaging (MRI) is the method of choice for further clarification, especially in patients where cranial computed tomography (CT) is inconspicuous. To investigate the presence of DAI after traumatic brain injury (TBI), a multimodal MRI approach is applied including the common structural and also functional imaging sequences. For structural MRI, fluid-attenuated inversion recovery (FLAIR) weighted and susceptibility contrast imaging (SWI) are the sequences mainly used. The SWI technique is extremely sensitive to blood breakdown products, which appear as small signal voids at three locations, at the gray-white interface, in the corpus callosum and in the brain stem. Functional MRI comprises a group of constantly developing techniques that have great potential in optimal evaluation of the white matter in patients after craniocerebral trauma. These imaging techniques allow the visualization of changes associated with shear injuries, such as functional impairment of axons and decreased blood flow and abnormal metabolic activity of the brain parts affected. The multimodal MRI approach in patients with DAI results in a more detailed and differentiated representation of the underlying pathophysiological changes of the injured nerve tracts and helps to improve the diagnostic and prognostic accuracy of MRI. When DAI is suspected multimodal MRI should be performed as soon as possible after craniocerebral injury. (orig.) [German] Das Rotationstrauma des Gehirns ist bei jungen Erwachsenen ein haeufiger Grund

  4. On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K. [comp.

    1998-09-01

    . Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 22%. Inzidenz Hepatome: - Exposition ueber 4 Wochen ab Tag 1: 47,6%, - Exposition ueber 4 Wochen ab 13. Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 1,7%. (B) Diethylnitrosamin, Dyroff et al., 1986: (DEN + Phenobarbital), Hepatokarzinomen nach Exposition von Ratten ueber 6 Wochen: - beginnend im Alter von 4 Wochen: 100% Inzidenz, - beginnend im Alter von 8 Wochen: 0% Inzidenz. (C) Benz(a)pyren, Vesselinovitch et al., 1975: Lebertumoren nach einmaliger parenteraler Applikation an Ratten: - im Alter von 1 Tag: maennl.: 81% weibl.: 18%, - im Alter von 42 Tagen: maennl.: 9%, weibl.: 0%. Wie die Untersuchung von Maltoni et al. (1981) zu Vinylchlorid zeigt, kann bei gleicher Expositionskonzentration eine Exposition junger Tiere ueber einen kurzen Zeitraum zu einer hoeheren Tumorinzidenz fuehren als das Langzeitexperiment mit erwachsenen Tieren. Fuer alle Stoffe mit Ausnahme von Saccharin wurde eine gentoxische Wirkung nachgewiesen. Dies laesst vermuten, dass der Mechanismus der Kanzerogenese wesentlichen Einfluss auf die Altersabhaengigkeit hat. Dies steht in Einklang mit den mechanistischen Ueberlegungen. (orig.)

  5. Long-term results of total body irradiation in adults with acute lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Marnitz, Simone; Zich, Alexander; Budach, Volker; Jahn, Ulrich; Neumann, Oliver [Charite University Medicine, Department of Radiation Oncology, Berlin (Germany); Martus, Peter [University Tuebingen, Institute of Clinical Epidemiology and Applied Biostatistics, Tuebingen (Germany); Arnold, Renate [Charite University Medicine, Campus CVK, Department of Hematology and Oncology, Bone Marrow Transplant Unit, Berlin (Germany)

    2014-05-15

    breadth. (orig.) [German] Ziel der Arbeit war die Auswertung der Akut- und Spaettoxizitaet sowie der Therapieergebnisse erwachsener Patienten mit akuter lymphatischer Leukaemie (ALL) nach Ganzkoerperbestrahlung (''total body irradiation'', TBI) als Teil des Therapiekonzepts. Im Rahmen einer retrospektiven Auswertung von 110 erwachsenen Patienten (34 ± 12 Jahre) mit ALL, die eine TBI (6-mal 2 Gy-12 Gy) vor Transplantation erhalten hatten, werden therapiebedingte Akut- und Spaettoxizitaet, Mortalitaet und Therapieergebnisse dargestellt. Die mittlere Nachbeobachtungszeit betrug 70 Monate. Die leukaemiefreien 2- und 5-Jahres-Ueberlebensraten betragen 78 bzw. 72 %. Nach im Median 7 Monaten erlitten 29 % (32/110) der Patienten ein medullaeres Rezidiv. Das Geschlecht war der einzige statistisch signifikante Faktor bezueglich des Gesamtueberlebens zugunsten der weiblichen Patienten. Die therapiebedingte Mortalitaets- und die Gesamtueberlebensraten nach 2 und 5 Jahren waren 16 und 22 %, bzw. 60 und 52,7 %. Die chronische ''Graft-versus-host''-Erkrankung (cGVHD) der Haut war die haeufigste Spaetreaktion (n = 33, 30 %), gefolgt von 15,5 % (17/110) pulmonaler cGVHD. Eine Lungenfibroseentwickelten 6 Patienten. Ophthalmologische Symptome berichteten 28 % (31/110); 11 % der Patienten (12/110) entwickelten eine symptomatische Osteoporose, 5/110 (4,5 %) eine Hypothyreose und 2 Patienten einen Diabetes mellitus. Von den maennlichen Patienten litten 11 % unter erektiler Dysfunktion oder Libidoverlust nach Therapie. Wegen menopausaler Beschwerden benoetigten 2/36 Frauen nach einer mittleren Zeit von 28 Monaten nach Therapie eine Hormonersatztherapie. Keine Patientin wurde nach Therapie schwanger. Es wurde weder eine akute noch eine spaete kardiale Toxizitaet dokumentiert, ebenso kein Sekundaermalignom. Obwohl das Therapieergebnis des vorliegenden Kollektivs im oberen Bereich der Literatur einzuordnen ist, bleiben sowohl die therapiebedingte

  6. Erstellung von Normkurven eines neu entwickelten Sprachaudiometrietests mit Einsilbern, genannt „Dynamischer Zahlentest“, zu drei verschiedenen Sprechern – Mann, Frau und Kind – und jeweils drei verschiedenen Sprachmodi – normal, gerufen und geflüstert – an normalhörenden Erwachsenen im Alter von 19-27 Jahren ohne Störgeräusch

    OpenAIRE

    Bolz, Sophia

    2011-01-01

    Ziel dieser Arbeit war es, mit Hilfe 35 normalhörender Probanden im Alter von 19-27 Jahren Schwellenkurven (Speech reception threshold) zu einem neu aufgenommenen dynamischen Einsilbertest mit den Zahlen eins bis zwölf (enthält den Zweisilber sieben) und den Farben braun, blau, gelb, grün, rot, schwarz und weiß zu erstellen. Die Versuche sollten zunächst orientierende Ergebnisse der Sprachverständlichkeiten zu den verschiedenen Sprachmodi ohne Störlärm liefern. Das Besondere an diesem spracha...

  7. Radiotherapeutic aspects of the treatment of adult patients with supradiaphragmatic Hodgkin's disease CS I/II. Pt. 1; Regarding the indications of primary and adjuvant radiotherapy. Fragen und Aspekte zur Radiotherapie bei erwachsenen Patienten mit lokalisierten supradiaphragmalen Stadien (CS I/II) eines Morbus Hodgkin. T. 1; Fragen und Aspekte zu den Indikationen einer primaeren und einer adjuvanten Radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Glanzmann, C. (Universitaetsspital, Klinik fuer Radio-Onkologie, Zurich (Switzerland)); Luetolf, U.M. (Universitaetsspital, Klinik fuer Radio-Onkologie, Zurich (Switzerland))

    1993-08-01

    Randomized studies of chemo- vs radiotherapy in patients with PS I/II A and some PS III A have shown conflicting results. Patients with supra-diaphragmatic Hodkin's disease and CS I/II can be subdivided according to radiotherapy as: 1. Patients with a very low or a low recurrence risk of approximately 10 to 20%: Patients less than 40 years old and CS I/II A NS/LP with less than three involved regions and no bulky mediastinal mass and an ESR below 30 mm. In the other patients, primary irradiation of an extended mantle field without a staging laparotomy is an acceptable primary treatment, achieving a recurrence-free survival rate of approximately 80%. Another option is a staging laparotomy with splenectomy and a mantle radiotherapy for PS I/II. Few groups prefer primary chemotherapy alone or some type of a reduced chemotherapy with lesser toxicity combined with localized radiotherapy and long-term observations of a larger group of patients after the last type of treatment have to confirm the excellent early results. 2. Patients with an intermediate recurrence risk of approximately 20 to 40%: Patients, who do not belong to group one or group 3. Patients less than 50 years old with CS I/II and an ESR less than 50 mm and without bulky mediastinal involvement and with one of the following signs: Three involved regions or MC or one B symptom. A patient with more than one of these signs or with two or three B symptoms should be classified in group 3. For these patients, we recommend staging laparotomy and radiotherapy if PS I/II or primary chemotherapy with or without radiotherapy of the involved regions. 3. Patients with a high recurrence risk (40% or higher): (Abstract Truncated)

  8. Die filmstilistische Darstellung von Klaras Gehbehinderung im Kinderfilm "Heidi"

    Directory of Open Access Journals (Sweden)

    Maria Ohrfandl

    2016-09-01

    Full Text Available Dieser Beitrag soll die Forschungslücke zur Darstellung von Behinderungen speziell im Kinderfilm im deutschsprachigen Raum füllen. Auf Basis einer neoformalistisch orientierten Filmanalyse nach Bordwell und Thompson (2008, wird anhand von drei Filmsequenzen eine mögliche Lesart des Kinderfilms "Heidi" (Marcus 2005 entwickelt, um die filmstilistische Darstellung der Gehbehinderung des Mädchens Klara zu untersuchen. Die Ergebnisse werden mit theoretischen Überlegungen zur Problematik der Begriffsbestimmung von Körperbehinderung sowie zur Mobilität und Selbstbestimmung von Menschen mit Körperbehinderungen in Bezug gesetzt. Dabei zeigt sich im Wesentlichen, dass im Kinderfilm "Heidi" (Marcus 2005 Klaras Gehbehinderung als 'heilbare Krankheit' und der Rollstuhl als Einschränkung von Mobilität begriffen wird. Außerdem unterliegt Klara aufgrund ihrer Körperbehinderung überwiegend der Fremdbestimmung von Erwachsenen. Zur Klärung wahrscheinlicher filmischer Bildungspotenziale werden die Ergebnisse schließlich anhand der von Jörissen und Marotzki (2009 entwickelten Orientierungsdimensionen "Wissens-, Handlungs-, Grenz- und Biographiebezug" diskutiert. This article aims to bridge a knowledge gap by showing ways of representing disabilities in the German children film genre. Using Bordwell and Thomson's (2008 neoformalistically orientated film analysis approach, the movie "Heidi" (Marcus 2005 is analysed. Bordwell and Thompson's (2008 method is applied to three sequences of "Heidi" in order to present an interpretation and to discuss the representation of Clara's walking impediment. The results are then associated with theoretical considerations regarding the mobility and self-determination of people with disabilities and problematic definitions of the term 'physical disability'. It is shown that characters in the children's film "Heidi" (Marcus 2005 regard Clara's walking impediment as a 'curable disease' and the wheelchair as a limitation

  9. The zero-point field. On the search for the cosmic basic energy; Das Nullpunkt-Feld. Auf der Suche nach der kosmischen Ur-Energie

    Energy Technology Data Exchange (ETDEWEB)

    McTaggart, L.

    2007-02-15

    Does an inexhaustable energy source exist from which all life is fed? A form of energy, which penetrates all dead and living expression forms of life? Does a logical, scientific explanation exist for parapsychological phenomena like clairvoyance, telepathy, ghost healing, synchronicity, and a model for the mode of action of homeopathy? Do serious researchers and scientific studies to be token in ernest exist, which not only deal with this questions but also have found answers? During eight years the British scientific journalist Lynne McTaggart has researched. ''Teh zero-point field'' is the result of numerous speeches with renowned physicists, biophysicists, neuroscientists, biologist, and consciousness researchers on the whole world, which have independently discovered phenomena, which are combined like puzzle pieces to a fascinating total picture.

  10. Suche nach dem Higgs-Boson in hadronischen Endzuständen mit fehlender Energie am L3-Experiment bei LEP

    CERN Document Server

    Zöller, Marc Henning

    2005-01-01

    This thesis presents searches for the Higgs boson, which is predicted by the Standard Model of Particle Physics and its extensions in order to endow fermions and bosons with their observed masses. While the Standard Model predicts only one Higgs boson »H«, the Minimal Supersymmetric Extension contains five Higgs bosons. This analysis refers to the light neutral »h«, which has nearly the same properties as the Standard Model Higgs boson. The analyses are based on data taken by the L3 experiment at the Large Electron Positron Collider (LEP) near Geneva during the years 1998 until 2000, which corresponds to an integrated luminosity of 629.7 pb−1 and which were collected in a center-of-mass energy range from 189 GeV to 209 GeV. The Higgs boson searches presented here analyse the data with regard to hadronic events with missing energy, since the visible energy is reduced compared to the total energy given by the LEP collider. According to theoretical prediction these final states can be produced via the Higg...

  11. Development of a low-emission automatic wood-chip firing system based on pyrolysis. Entwicklung einer emissionsarmen, automatischen Holzschnitzelfeuerung nach dem Vergaserprinzip

    Energy Technology Data Exchange (ETDEWEB)

    Graf, S. (ETH, Zurich (Switzerland))

    1991-05-01

    Within the framework of a project supported by the Commission for the Assistance of Scientific Research the prototype of a new wood chip firing has been developed. In this system wood is mainly thermally degassed. After the pyrolysis chamber the gas passes through a reduction chamber in which the nitrogen oxides evolved during degassing are reduced to elementary nitrogen. Then the combustion chamber follows which is equipped with fixed ceramic guide vanes which cause an angular momentum of the flame and thus ensure that the carbonization gases and combustion air are also in case of minimum load thoroughly mixed. After combustion the hot flue gases stream back around the pyrolysis chamber giving off a part of the heat and are then conducted to a heat exchanger. (BWI).

  12. Der Status des 'Mentalen' in kulturtheoretischen Handlungserklärungen. Zum Problem der Relation von Verhalten und Wissen nach Stephen Turner und Theodore Schatzki

    OpenAIRE

    Reckwitz, Andreas

    2000-01-01

    Der Artikel rekonstruiert und kommentiert die Versuche der US-amerikanischen Sozialtheoretiker Stephen P. Turner und Theodore R. Schatzki, den Status von 'kollektivem mentalem Wissen' in kulturtheoretischen Handlungserklärungen zu klären. Ausgangspunkt ist Turners Kritik am unreflektierten 'Mentalismus' vieler kulturtheoretischer Handlungserklärungen und seine Empfehlung eines Quasi-Behaviorismus als Gegenmodell. Foucaults und Geertz' 'Kultur als Text'-Ansätze und Schatzkis post-wittgensteini...

  13. Environmental radioactivity monitoring. 30 years after Chernobyl - what has changed?; Ueberwachung der Umweltradioaktivitaet. 30 Jahre nach Tschernobyl. Was hat sich veraendert?

    Energy Technology Data Exchange (ETDEWEB)

    Bieringer, Jacqueline [Bundesamt fuer Strahlenschutz, Freiburg (Germany). Fachgebiet SW 2.5; Steinkopff, Thomas [Deutscher Wetterdienst, Offenbach (Germany); Wershofen, Herbert [Physikalisch-Technische Bundesanstalt, Braunschweig (Germany). Lab. 6.301

    2016-05-01

    Since the 50ies environmental radiation monitoring was assigned to federal and federal state authorities with respect to radionuclide releases from USSR and US nuclear weapon tests. First fallout measurements were performed since 1953 at the measuring point Schauinsland by the University Freiburg. In consequence of the obligations form the Euratom treaty 1957 and the increasing civil nuclear power utilization the radiation monitoring was extended and legally regulated.

  14. Total nuclear phaseout. 30 years after Chernobyl. What still has to be done; Alle aussteigen. 30 Jahre nach Tschernobyl. Was noch zu tun ist

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-03-15

    The brochure of the German Federal Environment Ministry on the necessity of total nuclear phaseout 30 years after Chernobyl discusses the following issues that still have to be done: Search for a final repository in deep rocks, building of a steel dome for Chernobyl and the roadmap for nuclear phaseout.

  15. Rezension von: Julia Dombrowski: Die Suche nach der Liebe im Netz. Eine Ethnographie des Online-Datings. Bielefeld: transcript Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Vanessa Kleinschnittger

    2011-09-01

    Full Text Available Julia Dombrowski setzt sich in ihrer Dissertation aus ethnologischer Perspektive mit dem Phänomen Online-Dating auseinander. Dabei legt sie einen Fokus auf die Emotionen, insbesondere die romantische Liebe, und widmet sich der Frage, auf welche Weise von den User/-innen der Datingbörsen kulturspezifische Liebesvorstellungen und individuelles Erleben bei ihrer Partnersuche vereinbart werden. Damit weicht Dombrowski von der bestehenden, sich vor allem auf Kapitalismuskritik konzentrierenden Forschung zum Online-Dating ab und sucht den Zugang zum Thema über das subjektive emotionale Erleben des Online-Datings durch die User/-innen selbst.

  16. The climate-problem. Evaluation after the Paris-agreement and the Marrakesh-conference; Das Klimaproblem. Bewertung nach dem Paris-Abkommen und der Marrakesch-Konferenz

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2017-05-15

    The Paris-Climate-Agreement came into effect on November 4th 2016. Still, the contradiction in this agreement - ambitious goals and (presumably) inadequate commitments - has persisted. Also in the follow-up conference in Marrakesh, this discrepancy remained unresolved. 2017 the countries will meet again. However, since Donald Trump became president-elect of the United States of America, uncertainty about how the largest economy in the world will act in the future has intensified. This amplifies the pressure to clarify the true level of human influence on the climate in a scientifically consistent manner, as a basis for more reliable decisions. This paper tries to contribute to that effort.

  17. Medical management after contamination and incorporation of americium in occupational exposure. Medizinische Massnahmen nach Kontamination und Inkorporation von Americium bei beruflicher Strahlenexposition

    Energy Technology Data Exchange (ETDEWEB)

    Gensicke, F.; Stopp, G.; Scheler, R.; Klucke, H.; Czarwinski, R.; Naumann, M.; Hoelzer, F.; Ott, R.; Schmidt, I. (Staatliches Amt fuer Atomsicherheit und Strahlenschutz, Berlin (Germany, F.R.). Abt. Strahlenschutzmedizin)

    1990-10-01

    In handling with an ampule of {sup 241}Am-nitrate solution one person received an contamination of the body surface, especially the face and the hairs, and an internal contamination of americium. The paper presents the results obtained in medical management to reduced the contamination of the skin and of the incorporated radionuclide. The radioactivity of the body surface could be reduced up to small local areas. After treatment with DTPA (Ditripentat) the internal exposure decrease about 83%. (orig.).

  18. Magnetic resonance imaging in syringomyelia - follow-up studies after syringosubarachnoidal shunting with clinical correlation. MRT bei Syringomyelie - Verlaufskontrollen nach syringosubarachnoidalen Shuntoperationen mit klinischer Korrelation

    Energy Technology Data Exchange (ETDEWEB)

    Kahn, T.; Moedder, U. (Duesseldorf Univ. (Germany). Inst. fuer Diagnostische Radiologie); Roosen, N.; Lumenta, C.B.; Bock, W.J. (Duesseldorf Univ. (Germany). Neurochirurgische Klinik); Steinmetz, H. (Duesseldorf Univ. (Germany). Neurologische Klinik)

    1991-11-01

    In 8 patients with syringomyelia, MR long-term follow-ups (observation period 25-46 months) were done after syringosubrachnoidal shunt operations. MR showed directly after surgery in 6 cases an extensive collapse of the syringomyelias and in 2 cases a lesser reduction of the diameter of the syrinx. During the subsequent course the size of the cavities increased again in 3 cases. The size of the syrinx visualised by MR did not correlate with the clinical status during the follow-up studies. This seems to point to an insufficient representation of the disease process by the morphological visualisation of the size of the syrinx. (orig.).

  19. Automatisierung des Verfahrens nach Beyer & Schweiger (1969) zur Bestimmung von Durchlässigkeit und Porosität aus Kornverteilungskurven

    Science.gov (United States)

    Houben, Georg J.; Blümel, Martin

    2017-11-01

    Porosity is a fundamental parameter in hydrogeology. The empirical method of Beyer and Schweiger (1969) allows the calculation of hydraulic conductivity and both the total and effective porosity from granulometric data. However, due to its graphical nature with type curves, it is tedious to apply and prone to reading errors. In this work, the type curves were digitized and emulated by mathematical functions. The latter were implemented into a spreadsheet and a visual basic program, allowing the fast automated application of the method for any number of samples.

  20. Cosmetic results after breast conserving carcinoma treatment in patients with intramammarian seromas; Kosmetische Ergebnisse nach brusterhaltender, radiologischer Mammakarzinomtherapie bei Patientinnen mit intramammaeren Seromen

    Energy Technology Data Exchange (ETDEWEB)

    Schultze, J.; Loessl, K.; Kimmig, B. [Universitaetsklinikum Schleswig-Holstein, Kiel (DE). Klinik fuer Strahlentherapie (Radioonkologie)

    2008-07-01

    Introduction: There were 373 patients irradiated after breast conserving carcinoma treatment. A planning computed tomography revealed in 97 of these patients seromas and tissue defects exceeding 2 cm in diameter. The cosmetic results in those patients and the impact of seromas herein had to be evaluated. Patients and methods: Mean age was 59 years. A quadrant resection was performed in 17,5 percent of the patients, a segmental resection in 27,8 percent and a tumour excision in 54,6 percent. Radiation therapy was applied with the linear accelerator and 6 MeV photons up to a total dose in the residual breast of 50 Gy followed by a boost dose to the former tumour bed on 10 Gy. A distinct evaluation and documentation of therapy related side effects and the resulting cosmesis was done in 51 patients. Results: In all the examined seroma patients there were moderate acute skin reactions grade 1 to 3. As late effects in 82,3 percent scar indurations were noticed. At the skin 51 percent showed enhanced pigmentation, 68,6 percent atrophia and only 11 percent teleangiectasia. Subcutaneous fibrosis occurred in 56,9 percent of the patients, 78,4 percent of the women had breast asymmetries. In 41,2 percent there were a lymphedema subcutaneously, in 72,5 percent impaired sensibility. The overall cosmetic result documented with a 5 point score was 'very good' (score 1) in 19,6 percent and 'good' (score 2) in 33,3 percent, 37,3 percent were 'satisfactory' (score 3) and 9,8 percent 'bad' (score 4) respectively. No 'very bad' results (score 5) were seen. Conclusions: The cosmetic results in the examined group of seroma and hematoma patients were inferior to those reported in the literature. We conclude that post-operative seroma and hematoma have an adverse effect on the resulting cosmesis and that their frequency and extent have to be reduced in future by the responsible surgeons. (orig.)

  1. New approaches to variable displacement. What will be next after cylinder deactivation on gasoline engines?; Neue Wege zum variablen Hubvolumen. Was kommt nach der Zylinderabschaltung am Ottomotor?

    Energy Technology Data Exchange (ETDEWEB)

    Ross, J.; Grigoriadis, P.; Dingel, O.; Werler, A.; Neukirchner, H. [IAV GmbH, Chemnitz (Germany)

    2012-11-01

    Fuel economy results close to those of diesel engines could be obtained for the gasoline (Otto) engine in the New European Driving Cycle (NEDC) by means of cylinder deactivation (CDA). This can be achieved without renouncing the classical benefits of the gasoline engine such as low noise and emission levels or its typical liveliness. In cycles providing higher load fractions, the positive fuel economy effect of CDA can turn out to be much smaller. Additionally, shutting off cylinders by deactivating the intake and exhaust valves does not lead to significantly reduced friction torque in the engine. This article therefore discusses additional measures aimed at further decreasing fuel consumption such as the partial deactivation of the cranktrain, an asymmetric displacement split and a combination with variable valve lift. The fuel consumption scenarios discussed are based on experimental and simulation data from a turbocharged 1.6l four-cylinder gasoline engine. The impact of the measures described on vibration characteristics and the harshness of the engine is considered in the analysis of the fuel consumption potential. Design solutions for the suggested measures are illustrated and their impact on friction torque and fuel economy in cycles with higher load distribution is also demonstrated. (orig.)

  2. Das Opfer nach der Sintflut f�r die Gottheit(en des Alten Testaments und des Alten Orients: Eine neue Deutung

    Directory of Open Access Journals (Sweden)

    Gerlinde Baumann

    2013-09-01

    Full Text Available The Sacrifice for (the God(s after the Flood in Ancient Israel and the Ancient Near East: A New Interpretation. The experience of a large, devastating flood is part of the cultural heritage of mankind. The famous �texts of the deluge� come from Mesopotamia. Here, the flood tradition dates back to the 3rd Millennium. The longest and most traditional of these texts, which � amongst other things � deal with the interpretation of these events, is the Atramḫasis myth. The literary-dependent text is the Gilgamesh epic, and the Old Testament version is the story of the Flood that is found in Genesis 6�9. For a long time the similarities and differences between these three texts have been known. However, so far little attention was given to a passage that all three texts share: the sacrifice of the surviving humans after the Flood. The reaction of the deity(ies differs in these three texts. In this article I would like to consider the similarities and differences between the texts in order to evaluate the significance of the Old Testament text. This is against the background of recent insights in the field of ancient Israelite sacrifice, related to cultural anthropology. These three passages are first considered in their context and then compared to the relevant aspects of each other before a conclusion is drawn.

  3. The search for environment-friendly vehicles: will fuel cells win the race?; Suche nach umweltfreundlichen Fahrzeugen: Machen Brennstoffzellen das Rennen?

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1999-09-01

    Strict regulations in California force all major car manufacturers to build more environment-friendly vehicles: from 2003, 10 % of the cars produced by the seven leading manufacturers must be entirely free of emissions. At present, this holds true only of battery-powered electric vehicles. While, above all, DaimlerChrysler and Ford, but also General Motors and Toyota are developing fuel cell vehicles, BMW would rather place its stake on hydrogen-combustion engines. (orig.) [German] Strenge Vorgaben in Kalifornien zwingen alle grossen Autohersteller zum Bau umweltfreundlicherer Fahrzeuge. Denn ab 2003 muessen bei der sieben fuehrenden Produzenten zehn Prozent der Neuwagen komplett emissionsfrei sein. Momentan sind das aber nur batteriebetriebene Elektroautos. Waehrend vor allem DaimlerChrysler und Ford, inzwischen aber auch andere, wie General Motors und Toyota, Brennstoffzellenfahrzeuge entwickeln, setzt BMW eher auf wasserstoffgespeiste Verbrennungsmotoren. (orig.)

  4. Die Radiofrequenz-Kyphoplastie zur Behandlung osteoporotischer und neoplastischer Wirbelkörperfrakturen. Erste Erfahrungen und klinische Ergebnisse nach 6 Monaten

    OpenAIRE

    Elgeti F; Gebauer B

    2010-01-01

    Die Vertebroplastie und die konventionelle Kyphoplastie mittels Ballon oder Stent sind etablierte Verfahren zur Behandlung schmerzhafter, konservativ-medikamentös therapieresistenter, osteoporotischer und neoplastischer Wirbelkörperfrakturen. Die Radiofrequenz-Kyphoplastie mithilfe eines ultrahochviskösen Zements stellt eine innovative Methode dar. Sie ermöglicht eine sichere und effektive Schmerztherapie bei osteoporotischen und neoplastischen Wirbelkörperfrakturen bei gleichzeitig...

  5. Die Radiofrequenz-Kyphoplastie zur Behandlung osteoporotischer und neoplastischer Wirbelkörperfrakturen. Erste Erfahrungen und klinische Ergebnisse nach 6 Monaten

    Directory of Open Access Journals (Sweden)

    Elgeti F

    2010-01-01

    Full Text Available Die Vertebroplastie und die konventionelle Kyphoplastie mittels Ballon oder Stent sind etablierte Verfahren zur Behandlung schmerzhafter, konservativ-medikamentös therapieresistenter, osteoporotischer und neoplastischer Wirbelkörperfrakturen. Die Radiofrequenz-Kyphoplastie mithilfe eines ultrahochviskösen Zements stellt eine innovative Methode dar. Sie ermöglicht eine sichere und effektive Schmerztherapie bei osteoporotischen und neoplastischen Wirbelkörperfrakturen bei gleichzeitiger Schonung der intakten trabekulären Knochensubstanz.

  6. Determination of the biogas and methane yield of selected energy crops. [NAchWAchsende ROhstoffe]; Ermittlung der Biogas- und Methanausbeute ausgewaehlter Nawaro

    Energy Technology Data Exchange (ETDEWEB)

    Ohl, Susanne

    2011-11-15

    The aim of this paper is the characterization of substrate quality and methane yield of different energy crops, which were cultivated in Schleswig-Holstein. The specific methane production of 224 variants was determined in with Hohenheim biogas yield test (HBT), 72 variants were investigated in a common batch test. The specific methane production (HBT) is 359-371 l{sub N}/kg{sub oDM} for wheat, 358-378 l{sub N}/kg{sub oDM} for maize and 341-372 l{sub N}/kg{sub oDM} for perennial ryegrass. The results for the specific methane production are due to a systematic offset in the batch experiment always below those of the HBT. Silages achieve higher gas yields than fresh substrates. The mass losses, which occur during ensiling, were compensated due to the higher gas yields. Maize is compared with other energy crops superior in terms of the yield per hectare. The experimentally determined methane yields showed a good agreement with calculated theoretical methane yields (method of WEIssBACH 2008, 2009).

  7. Reduzierte Schleimproduktion durch den Wirkstoff 1,8-Cineol nach einer bakteriellen Infektion in einem neu entwickelten ex-vivo Modell

    OpenAIRE

    Brotzmann, V; Sudhoff, H; Ebmeyer, J; Kaltschmidt, B; Kaltschmidt, C

    2017-01-01

    Diverse Erkrankungen des Atmungssystems wie Rhinosinusitis, chronische Lungenerkrankungen, wie COPD oder bronchiales Asthma gehen einher mit einer starken Überproduktion und Hypersekretion von Schleim in den Atemwegen. Der Wirkstoff 1,8-Cineol, des Arzneimittels Soledum®, kann zur Behandlung solcher entzündlicher Atemwegserkrankungen verwendet werden. In der vorliegenden Studie haben wir eine ex-vivo Kultur der menschlichen Nase etabliert, um die Auswirkungen von 1,8-Cineol auf die Schleimhyp...

  8. Magnet discolation - An increasing and serious complication following MRI in patients with chochlear implants; Magnetdiskolation - eine zunehmende und folgenreiche Komplikation nach MRT bei Patienten mit Cochlea Implantat

    Energy Technology Data Exchange (ETDEWEB)

    Hassepass, F.; Staubenau, V.; Arndt, S.; Beck, R.; Grauvogel, T.; Aschendorff, A. [Univ. Medical Center Freiburg (Germany). Dept. of Otorhinolaryngology-Head and Neck Surgery; Bulla, S. [Univ. Medical Center Freiburg (Germany). Dept. of Diagnostic Radiology

    2014-07-15

    Cochlear implantation (CI) represents the gold standard in the treatment of children born deaf and postlingually deafened adults. Initial magnetic resonance imaging (MRI) was contraindicated in CI users. Meanwhile, there are specific recommendations concerning MRI compatibility depending on the type of CI system and the device manufacturer. Some CI systems are even approved for MRI with the internal magnet left in place. The aim of this study was to analyze all magnet revision surgeries in CI patients at one CI center and the relationship to MRI scans over time. Between 2000 and 2013, a total of 2027 CIs were implanted. The number of magnet dislocation (MD) surgeries and their causes was assessed retrospectively. In total 12 cases of MD resulting from an MRI scan (0.59 %) were observed, accounting for 52.2 % of all magnetic revision surgeries. As per the labeling, it was considered safe to leave the internal magnet in place during MRI while following specific manufacturer recommendations: MRI intensity of 1.5 Tesla (T) and compression head bandage during examination. A compression head bandage in a 1.5 T MRI unit does not safely prevent MD and the related serious complications in CI recipients. We recommend a Stenvers view radiograph after MRI with the internal magnet in place for early identification of MD, at least in the case of pain during or after MRI examination. MRI in CI patients should be indicated with restraint and patients should be explicitly informed about the possible risks. Recommendations regarding MRI compatibility and the handling of CI patients issued with MRI for the most common CI systems are summarized.

  9. Review: Claudia Rademacher & Peter Wiechens (Hrsg.) (2000). Verstehen und Kritik. Soziologische Suchbewegungen nach dem Ende der Gewissheiten. Festschrift für Rolf Eickelpasch

    OpenAIRE

    Osterwalder, Daniel

    2004-01-01

    Verstehen und Kritik" ist der Versuch, der Unübersichtlichkeit unserer Zeit, unserer Sozialsysteme und dem Abschied von den großen Gesamtentwürfen und Großerzählungen verschiedene Suchbewegungen entgegenzustellen. Damit soll das Nebeneinander von sehr unterschiedlichen theoretischen Perspektiven zu Tage gefördert werden. Durch methodische und theoretische Reflexionen und Analysen, die beispielsweise dem Trennenden, aber auch den Affinitäten zwischen den Arbeiten der Frankfurter Schule und jen...

  10. Nachtraege zu den „Tertiaerschichten auf Java.” 1ter Nachtrag: Mollusken. Nach Sammlungen der Indischen Bergbeamten, Hunghuhn’s und Reinwardt’s

    NARCIS (Netherlands)

    Martin, K.

    1881-01-01

    Durch Vermittelung Verbeek’s erhielt ich eine grosse Reihe von Versteinerungen, welche von Bergbeamten Indiens (hauptsächlich von R. Everwijn und P. van Dijk) gesammelt waren und sich bis vor Kurzem, ohne näher untersucht zu sein, in Batavia befanden ¹). Diese Sammlung umfasste neben vielem

  11. Analysis of free ACh and 5-HT in milk from four different species and their bioactivity on 5-HT(3) and nACh receptors.

    Science.gov (United States)

    Gallegos-Perez, Jose-Luis; Limon, Agenor; Reyes-Ruiz, Jorge M; Alshanqeeti, Ali S; Aljohi, Mohammad A; Miledi, Ricardo

    2014-07-25

    Milk is one of the most beneficial aliments and is highly recommended in normal conditions; however, in certain disorders, like irritable bowel syndrome, cow milk and dairy products worsen the gastric symptoms and their use is not recommended. Among the most recognized milk-induced gatrointestinal symptoms are abdominal pain, nausea and vomiting, which are processes controlled by cholinergic and serotonergic transmission. Whether the presence of bioavailable ACh and 5-HT in milk may contribute to normal peristalsis, or to the developing of these symptoms, is not known. In this work we attempt to determine whether the content of free ACh and 5-HT is of physiological significance in milk from four different species: cow (bovine), goat, camel and human. Liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was used to identify and quantify free ACh and 5-HT in milk, and activation of the serotonergic and cholinergic ionotropic receptors was investigated using electrophysiological experiments. Our principal hypothesis was that milk from these four species had sufficient free ACh and 5-HT to activate their correspondent receptors expressed in a heterologous system. Our results showed a more complex picture, in which free ACh and 5-HT and their ability to activate cholinergic and serotonergic receptors are not correlated. This work is a first step to elucidate whether 5-HT and ACh, at the concentrations present in the milk, can be associated to a direct function in the GI.

  12. The value of bone scintigraphy in patients with pain in the thigh following cementless hip endoprosthesis. Aussagefaehigkeit der Skelettszintigraphie bei Oberschenkelschmerz nach zementlosem Hueftgelenkersatz

    Energy Technology Data Exchange (ETDEWEB)

    Ehrenheim, C. (Medizinische Hochschule Hannover (Germany). Abt. Nuklearmedizin und Spezielle Biophysik); Steinmetz, M.; Pohlemann, T. (Medizinische Hochschule Hannover (Germany). Unfallchirurgische Klinik); Tscherne, H. (Medizinische Hochschule Hannover (Germany). Unfallchirurgische Klinik)

    1993-04-01

    Persisting postoperative pain of the thigh is a common problem of cementless hip endoprostheses occurring in about 15-20% of the patients. We performed a comparative study including patients with (n=40) and without (n=45) pain of the thigh. 85 cementless porous-coated anatomic (PCA) hip endoprostheses in 74 patients were examined. All patients underwent clinical examination including a standardized questionnaire, X-ray, and 3-phase bone scintigraphy. Slight or moderate [sup 99m]Tc-MDP uptake in the area of the greater and lesser trochanter as well as at the tip was a common finding in PCA prostheses in patients without pain and was not a sign of loosening of the hip. Radiologically, there was no difference between patients with and without pain. However, persisting pain of the thigh in patients with PCA prosthesis corresponded with an increased uptake at the tip and the medial and lateral femur, not being a sign of loosening even in this group. The special biomechanical conditions of cementless prostheses causing inhomogeneous intraosseous stress distrubution are supposed to be the reason for that. (orig.)

  13. Climate to measure. Facility management for Universal Music at Berlin; Klima nach Mass. TGA-Planung fuer Universal Music in Berlin

    Energy Technology Data Exchange (ETDEWEB)

    McLead, E.A.

    2002-07-01

    Designing and constructing the technical facilities for a historical building like the 'Spreespeicher' in Berlin is a difficult but interesting task. The building is owned by Universal Music. Each department has its own office structure, and all offices and structures were integrated in a functional overall concept by the planners of Happold Ingenieure. [German] Klima, Lueftung und Elektroinstallation fuer ein historisches Gebaeude wie den Berliner Spreespeicher zu entwickeln, ist eine schwierige, aber reizvolle Aufgabe. Besonders, wenn der Nutzer Universal Music heisst: Jede Abteilung besitzt ihre eigene Buerostruktur, und alle mussten die TGA-Planer von Happold Ingenieure in ein funktionierendes Gesamtkonzept integrieren. (orig.)

  14. Determination of F-, Cl-, Br- and S-contents after combustion-disclosure. Fluor-, Chlor-, Brom- und Schwefel-Gehaltsbestimmung nach Verbrennungsaufschluss

    Energy Technology Data Exchange (ETDEWEB)

    Albrich, H. (GIU GmbH, Teningen (Germany)); Mueller, M. (GIU GmbH, Teningen (Germany)); Pinhack, H. (IKA-Analysentechnik, Heitersheim (Germany))

    1994-08-01

    The presentation demonstrates a method to gain efficient parallel determination of F-, Cl-, Br- and S-contents in combustible material including the determination of the calorific heat of combustion. The principle of the analysis is based on the complete oxidation of the organic sample matrix by combustion in a calorimetric container after applying with an oxygen pressure of 30 bar. Organic halides and sulfur compounds are thereby converted into the corresponding halides and/or SO[sub 3]. After all combustion products are transferred into an aqueous absorption media, the halide and sulfate contents are evaluated by ionchromatography. The procedure is to be completed within 20-30 minutes and can be reproduced easily. The detection limit of the single elements lies under 0.01 weight-%. (orig.)

  15. Subjective perception of radioactivity. No change post successful treatment with radioiodine; Strahlen bleiben boese. Keine Aenderung der subjektiven Konzepte von Radioaktivitaet nach erfolgreicher Radioiodtherapie

    Energy Technology Data Exchange (ETDEWEB)

    Freudenberg, L.S.; Mueller, S.P.; Beyer, T.; Bockisch, A. [Universitaetsklinikum Essen (Germany). Klinik fuer Nuklearmedizin

    2009-07-01

    We assess the attitude of patients with thyroid disease towards radiation and radioactivity before and after radioiodine therapy by means of a cultural-anthropological approach. We evaluate in patient interviews how their subjective attitude towards radioactivity as an abstract term and towards radioactivity in the medical context on the basis of their personal experiences with radionuclide therapy. 29 patients with autonomously functioning thyroid lesions (17 women, 12 men, 35-79 years) were included in this study. All patients were interviewed prior to and 22-27 month post radioiodine therapy in an open dialogue with the principal investigator. Patients were asked to describe their attitude towards radioactivity in general and towards radioiodine therapy in particular. Patients were asked to use a scoring system (1: positive, 5: negative) to quantify their perception of radioactivity. The personal perception of radioactivity as an abstract term does not change significantly (p = 0.15) before and after radioiodine therapy. This perception is linked to mostly negative impressions of radiactivity. However, patients become more positive when assessing the value of radioactivity as part of their therapy regimen. Thus, we observe a significant increase in percepted value of radioactivity post radioiodine therapy (p = 0.03). Patients continue to view radioactivity as something negative despite treatment success following radioiodine therapy. Our results provide useful information for patient information by the nuclear medicine physician prior to a radioiodine therapy. (orig.)

  16. Optimierung der Photonenselektion für die Suche nach dem Zerfall des Higgsbosons in zwei leichte CP-ungerade Skalare

    CERN Document Server

    Braren, Früd; Schleper, Peter

    In some extensions of the Standard Model, extended Higgs sectors are postulated, from which, in addition to the Standard Model-like Higgs boson, a new CP-odd scalar arises. If this scalar’s mass is small, final states consisting of two photon pairs would be generated by the decay of the Higgs boson into two of the above mentioned scalars and the subsequent decays of the scalars into photon pairs. In the ATLAS detector, such a pair of photons would be reconstructed as a single photon. In order to analyse the data generated by the ATLAS detector at the LHC, one needs to know the efficiency of the photon pairs to be identified as a single photon. Using Monte-Carlo simulations, this identification efficiency is calculated and analysed for several photon selections and for three different masses of the scalar in the mass range of 100 to 400 MeV. This leads to the creation of an optimized cut menu for this final state. The aim of this is to make the analysis of the ATLAS-generated data with regard to this special...

  17. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?; Waermenetze heute und nach dem EEG. Ein Betriebszweig fuer die Landwirtschaft?

    Energy Technology Data Exchange (ETDEWEB)

    Clemens, Dietrich; Billerbeck, Hagen [Treurat und Partner Unternehmensberatungsgesellschaft mbH, Lueneburg (Germany). Abt. ' ' Climate and Energy' '

    2016-08-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  18. An Bord des Lebens - Die Schiffspassage deutscher Juden nach Palästina 1933 bis 1938 als Übergangserfahrung zwischen Raum und Zeit

    Directory of Open Access Journals (Sweden)

    David Jünger

    2015-09-01

    Full Text Available This article deals with the passage of German Jews to Palestine between 1933 and 1938 and concentrates on the ship passage itself. I focus on the stories, descriptions and reflections of the travelers that can be found in diaries, letters, travelogues, or even novels, which some of them wrote after the trip. On the ship these travelers found themselves torn between different spaces: Europe, Asia, and “the Orient” and also between different times: the Old Europe of the enlightenment of the individual and the New Jewish Homeland of the redemption of the Jewish collective. The overall topic that came to the fore in the reflections of the travelers is the search for the meaning of contemporary Jewish life as well as future prospects under worsening conditions not only in Germany but also in many other parts of Europe.

  19. A case study of internal dosimetry after inhalation of UF{sub 6}; Eine Fallstudie zur internen Dosimetrie nach Inhalation von UF{sub 6}

    Energy Technology Data Exchange (ETDEWEB)

    Froning, M.; Hill, P. [Forschungszentrum Juelich GmbH, Juelich (Germany)

    2012-07-01

    During a release of UF{sub 6} in a nuclear installation an employee was contaminated. Extensive incorporate monitoring of urine and feces, as well as measurements of blood, nose blow- and sputum samples on {sup 234}U, {sup 235}U and {sup 238}U were performed. The sampling period covered about 4 weeks. This case study describes the process of incorporation monitoring. The internal dose assessment will be presented. Later samples proved to be of especial importance with respect to dose evaluation. (orig.)

  20. The process of obtaining approvals for the ICE 3 to run from Germany to France; Zulassung des ICE 3 fuer den Verkehr nach Frankreich. Der Prozess

    Energy Technology Data Exchange (ETDEWEB)

    Panier, F. [Deutsche Bahn AG, Muenchen (Germany)

    2006-09-15

    Obtaining the necessary approvals for the ICE 3 in France is part of the process of providing trains for the SNCF's and Deutsche Bahn's joint ''Rhealys'' project. Both the railways and the authorities in both France and Germany have decided to pursue a new approach, doubtlessly influenced by the endeavours to liberalize railway traffic in Europe and by the continuous regulatory evolution in the European Union and at national level in each of its member countries. The results of this approach are jointly complied reference lists for the approval of both the TGV and the ICE as well as statements of departures from the TSI. This pioneering work has become the springboard for other comparable approaches for obtaining approvals for locomotives and has sparked a new EU initiative.

  1. Energy recovery from green wood and waste wood according to the new EEG; Energetische Verwertung von holzigen Gruenabfaellen und Resthoelzern nach dem neuen EEG

    Energy Technology Data Exchange (ETDEWEB)

    Strohmeyer, Anemon [Bundesverband der Altholzaufbereiter und -verwerter e.V., Berlin (Germany)

    2012-11-01

    The EEG has decisive influence on the further development of biomass power plants. Changes in the markets for ligneous green waste and waste wood caused a reconsideration and adaptation of specifications in the EEG 2012. It is assumed that construction of new biomass power plants will slow down with the new regulations and the pressure on utilisation of ligneous biomass will not increase further. Energy recovery from green waste and waste wood is already under strong competition from materials recovery processes and from conventional power plants interested in cocombustion of CO{sub 2}-neutral waste wood. (orig.) [German] Das EEG hat entscheidenden Einfluss auf die Entwicklung des Anlagenparks der Biomassekraftwerke. Die Veraenderung der Maerkte fuer holzartige Gruenabfaelle und Resthoelzer fuehrte dazu, dass die Anreize und Impulse des EEG ueberprueft und angepasst werden mussten. Das EEG 2012 nimmt insoweit wichtige Systemkorrekturen vor. Unter der Geltung des neuen EEG ist daher davon auszugehen, dass der Anlagenpark langsamer wachsen und der Nutzungsdruck auf holzartige Biomasse nicht weiter ansteigen wird. Denn die energetische Verwertung von holzartigen Gruenabfaellen und Resthoelzern steht bereits heute unter erheblichem Konkurrenzdruck durch die stoffliche Verwertung der geeigneten Qualitaeten und durch konventionelle Kraftwerke, die an dem CO{sub 2}-neutral verbrennenden Wertstoff interessiert sind. (orig.)

  2. MRI after patellar dislocation. Assessment of risk factors and injury to the joint; MRT nach Patellaluxation. Quantifizierung der Risikofaktoren und Beschreibung der Folgeschaeden

    Energy Technology Data Exchange (ETDEWEB)

    Diederichs, G. [Charite Universitaetsmedizin, Berlin (Germany). Radiologie; Scheffler, S. [Charite Universitaetsmedizin, Berlin (Germany). Zentrum fuer Muskuloskeletale Chirurgie; Chirurgisch Orthopaedischer PraxisVerbund, Berlin (Germany)

    2013-07-15

    Patellar dislocation is the lateral displacement of the patella from the femoral trochlea. Affected individuals typically have underlying anatomic risk factors of variable magnitude, which, in conjunction with leg rotation, cause the event. Magnetic resonance imaging (MRI) permits straightforward diagnosis of the typical features of recent patellar dislocation: contusion edema of the inferomedial patella and the lateral femoral condyle as well as rupture of the medial patellofemoral ligament. In case of concomitant osteochondral injury, early surgical refixation may be indicated, depending on the size. After a first dislocation, which can damage the capsuloligamentous stabilizers, subjects may sustain further dislocations or even develop chronic patellofemoral instability, depending on the presence and severity of anatomic variants. A wide range of conservative and surgical treatments are available. While a first patellar dislocation is often treated conservatively, surgical strategies after a second dislocation depend on the pattern of injury and the severity of underlying anatomic risk factors. The most relevant predisposing variants are trochlear dysplasia, patella alta, and an abnormal tibial tubercle to trochlear groove distance (TT-TG). The radiologist's report should give a quantitative estimate of both the injuries resulting from dislocation and the underlying anatomic risk factors. An accurate characterization of the individual pathomechanism is crucial for tailoring treatment. (orig.)

  3. Accident analyses in nuclear power plants following external initiating events and in the shutdown state. Final report; Unfallanalysen in Kernkraftwerken nach anlagenexternen ausloesenden Ereignissen und im Nichtleistungsbetrieb. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Loeffler, Horst; Kowalik, Michael; Mildenberger, Oliver; Hage, Michael

    2016-06-15

    The work which is documented here provides the methodological basis for improvement of the state of knowledge for accident sequences after plant external initiating events and for accident sequences which begin in the shutdown state. The analyses have been done for a PWR and for a BWR reference plant. The work has been supported by the German federal ministry BMUB under the label 3612R01361. Top objectives of the work are: - Identify relevant event sequences in order to define characteristic initial and boundary conditions - Perform accident analysis of selected sequences - Evaluate the relevance of accident sequences in a qualitative way The accident analysis is performed with the code MELCOR 1.8.6. The applied input data set has been significantly improved compared to previous analyses. The event tree method which is established in PSA level 2 has been applied for creating a structure for a unified summarization and evaluation of the results from the accident analyses. The computer code EVNTRE has been applied for this purpose. In contrast to a PSA level 2, the branching probabilities of the event tree have not been determined with the usual accuracy, but they are given in an approximate way only. For the PWR, the analyses show a considerable protective effect of the containment also in the case of beyond design events. For the BWR, there is a rather high probability for containment failure under core melt impact, but nevertheless the release of radionuclides into the environment is very limited because of plant internal retention mechanisms. This report concludes with remarks about existing knowledge gaps and with regard to core melt sequences, and about possible improvements of the plant safety.

  4. Veränderte Bewertung von Pedelecs nach einer Testerfahrung. Unterschiede zwischen Mobilitätstypen und Wegezwecken am Beispiel der Basler Energy Tours

    OpenAIRE

    Reichenbach, Max; Bruppacher, Susanne; Holm, Patricia

    2015-01-01

    Das Pedelec gilt als umweltfreundliches Verkehrsmittel. Seine Verbreitung wird durch umweltpolitische Interventionen wie z.B. die sog. Energy Tours in der Stadt Basel gefördert. Dies erfordert ein gründliches Verständnis der Entscheidungs- und Handlungsroutinen potentieller Nutzer. In dieser Studie wurden Teilnehmende an einer Pedelec-Testfahrt im Rahmen einer Energy Tour zu ihren mobilitätsbezogenen Einstellungen und ihrer Bewertung des Verkehrsmittels Pedelec für verschiedene Wegzwecke (Arb...

  5. Der neue Film "A Serious Man" von den Coen-Brothers : ein Quantenphysiker auf der Suche nach göttlichen Antworten

    OpenAIRE

    Giesen, Roman

    2010-01-01

    A Serious Man, der neuste Spielfilm des Regie-Brüderpaars Ethan und Joel Coen ist eine ironische bis zynische, von autobiographischen Zügen geprägte Reminiszenz an die Jugenderlebnisse der Filmemacher in einem kleinen jüdisch geprägten Vorort im mittleren Westen der USA und zudem eine gelungene Persiflage amerikanischer Alltagskultur des Jahres 1967, die spielerisch und erheiternd grundsätzlich offene philosophische Fragen thematisiert.

  6. Das Opfer nach der Sintflut f�r die Gottheit(en) des Alten Testaments und des Alten Orients: Eine neue Deutung

    OpenAIRE

    Gerlinde Baumann

    2013-01-01

    The Sacrifice for (the) God(s) after the Flood in Ancient Israel and the Ancient Near East: A New Interpretation. The experience of a large, devastating flood is part of the cultural heritage of mankind. The famous �texts of the deluge� come from Mesopotamia. Here, the flood tradition dates back to the 3rd Millennium. The longest and most traditional of these texts, which � amongst other things � deal with the interpretation of these events, is the Atramḫasis myth. The literary-dependen...

  7. Late results after intertrochanteric varus angulation in aseptic femoral head necrosis in adults. Spaetergebnisse nach intertrochanterer Varisierungsosteotomie bei der aseptischen Hueftkopfnekrose Erwachsener

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, E.; Ahrendt, J.; Niethard, F.U.; Blaesius, K. (Heidelberg Univ. (Germany, F.R.). Orthopaedische Klinik und Poliklinik)

    1989-04-01

    25 patients suffering from femoral head necrosis in 30 hip joints were radiologically studied for an average of 11.6 years following intertrochanteric varus angulation osteotomy. Preoperatively only stages 2 and 3 according to Meyers were seen. The follow-up results could be distributed into 4 groups. At best the osteonecrosis was reconstructed within 6 to 9 years while the trabeculae started to become rearranged within 2 to 4 years. At worst, rapid destruction in absence of bony reaction was observed. The ability of the bone outside the osteonecrosis to react to changed circumstances following angulation osteotomy correlates with long-term results. This may indicate a general osteopathy even outside the necrotic area. (orig.).

  8. More efficient low-voltage grid after structural change. Saving potentials on grid- and operating cost; Effizienteres Niederspannungsnetz nach Strukturaenderung. Einsparpotenziale bei Netz- und Betriebskosten

    Energy Technology Data Exchange (ETDEWEB)

    Maximini, Martin; Prause, Uwe; Mager, Thilo [ABB AG, Mannheim (Germany). Elektrische Systemberatung; Causemann, Franz [EWR Netz GmbH, Remscheid (Germany). Bereich Asset Management, Netzvertrieb; Pabst, Hartmut [EWR Netz GmbH, Remscheid (Germany). Anlagen- und Netzplanung

    2009-08-24

    In view of the current boundary conditions, i.e. simplified grid structure, reduction of the number of substations, longer service life of substations, and retardation of maintenance cycles, EWR Netz decided in 2008 to put the multistrand low-voltage grids in the city of Remscheid out of operation and to use intrinsically meshed low-voltage grids fed by substations instead. The necessary steps were calculated in advance using the Neplan software in an iterative process in cooperation with the Electric System Consultancy Service of ABB and then put into practice. The project is presented in detail in this contribution. (orig.)

  9. Radiation dose reduction in digital plain radiography of the knee after total knee arthroplasty; Dosisreduktion in der digitalen Radiografie des Kniegelenkes nach endoprothetischem Gelenkersatz

    Energy Technology Data Exchange (ETDEWEB)

    Kloth, J.K.; Kauczor, H.U.; Weber, M.A. [University Hospital Heidelberg (Germany). Clinic for Diagnostic and Interventional Radiology; Tanner, M.; Ewerbeck, V. [University Hospital Heidelberg (Germany). Center of Orthopedics, Trauma and Spinal Cord Injury; Stiller, W. [German Cancer Research Center (DKFZ), Radiology (E010), Heidelberg (Germany); Burkholder, I. [Univ. of Applied Sciences of the Saarland, Dept. of Nursing and Health, Saarbruecken (Germany)

    2015-08-15

    To reduce radiation exposure of frequently performed radiographs of the knee in follow-up of total-knee arthroplasty ensuring accurate assessment by using objective quality control criteria. In this prospective randomized study 278 radiographs of the knee in follow-up of total-knee arthroplasty were performed with standard and 37 % reduced radiation dose. The evaluation of the plain-radiographs was conducted using the following criteria: bone-implant interface, implant-surface character, implant-implant discrimination and periarticular heterotopic ossification. Two radiologists evaluated these criteria using a score ranging from 1 (definitely assessable) to 4 (not assessable). If a single criterion had been evaluated with a score ≥ 3 or more than 2 criteria with ≥ 2 points, the radiograph was score das ''not assessable''. The study was designed as non-inferiority-trial. 100 % of examined radiographs were scored as assessable, hence no statistical inferiority between the examinations with standard and reduced dose could be observed. Singular assessment of the defined criteria was likewise dose-independent. Plain-radiography of the knee following total-knee arthroplasty can be performed with 63 % of standard dose without loss of diagnostic validity.

  10. Rehabilitation of the unit control system at an industrial power station after 37 years of operation; Ertuechtigung der Blockleittechnik in einem Industriekraftwerk nach 37jaehriger Betriebszeit

    Energy Technology Data Exchange (ETDEWEB)

    Zgorzelski, P.; Wenzlaff, R. [Bayer AG, Leverkusen (Germany); Edelburg, J. [Siemens AG, Erlangen (Germany)

    1998-04-01

    The paper describes how the control system of an industrial power plant unit has been renovated in the short timescale of 12 weeks in parallel with rehabilitation measures on the pressure parts of the boiler. The short period of implementation has been made possible by detailed preliminary planning, extensive advance manufacture of components with subsequent system testing as well as by flexible working by the personnel. The installation of new switchgear rooms for MVR and electrical systems in the immediate vicinity of the boiler has proved advantageous and permitted a part of the field and switchgear room installation to be carried out before the shutdown of the unit. Experience available so far with the new process control system has been mainly positive. (orig.) [Deutsch] Es wird beschrieben, wie die Leittechnik eines Industriekraftwerksblockes in einem engen Zeitraum von zwoelf Wochen parallel zu Sanierungsmassnahmen am Druckteil des Kessels erneuert wurde. Die kurze Realisierungszeit wurde durch detaillierte Vorplanung, weitgehende Vorfertigung der Komponenten mit anschliessendem Systemtest sowie flexiblem Personaleinsatz ermoeglicht. Vorteilhaft erwies sich die Schaffung neuer Schaltraeume fuer MSR- und E-Technik in direkter Naehe des Kessels, was erlaubte, einen Teil der Feld- und Schaltrauminstallation schon vor dem Abstellen des Blockes durchzufuehren. Die bisher vorliegenden Erfahrungen mit dem neuen Prozessleitsystem sind ueberwiegend positiv. (orig.)

  11. The situation of nuclear rower after Fukushima. Public perception and political decisions; Die Situation der Kernenergie nach Fukushima. Wahrnehmung der Oeffentlichkeit und politische Entscheide

    Energy Technology Data Exchange (ETDEWEB)

    Gallego Carrera, Diana [Stuttgart Univ. (Germany). Zentrum fuer Interdisziplinaere Risiko- und Innovationsforschung; Hampel, Juergen [Stuttgart Univ. (Germany). Abt. fuer Technik- und Umweltsoziologie

    2013-03-15

    When nuclear power was introduced for electricity production in the mid-1950s, the access to nearly unlimited energy reserves it promised was expected to make the scarcity of energy supply a problem of the past. In the light of such expectations, the first nuclear reactors for electricity generation were built in Germany in the 1960s and in Switzerland in the late 1960s. Only a few years later, as early as in the 1970s, nuclear power developed into one of the present technologies discussed most controversially. While nuclear proponents considered the risks associated with the use of nuclear power low, nuclear opponents insisted mainly on debating the extent to which the risks of nuclear power were acceptable even if the probability of occurrence was low. History shows that there is no straight path in the development of nuclear power. While France made nuclear power the backbone of electricity production, other countries were much more reluctant to use nuclear power. After quite dramatic discussions in the 1970s and 1980s nuclear power seemed to develop into an unpopular but necessary evil to be accepted temporarily - whatever the definition of temporarily may be - until alternative sources of energy would replace it. Also in the social sciences, attention from the 1990s on concentrated on other topics, moving nuclear power into the background of interest. At present, the future of nuclear power looks rather bleak, at least in Germany and in Switzerland. The probability of change in the near future is discussed in this article. Attitudes towards nuclear power are analyzed first. A number of opinion polls, some of them permitting international comparison, allow public attitudes towards nuclear power in Europe, Germany, and Switzerland to be assessed. A next step deals with the cognitive background to attitudes, looking at risks and risk perception from a scientific perspective of risk studies. Another point considered is the identity of societally visible players who back nuclear power, and that of the players in society who act against this source of energy. (orig.)

  12. Building ground analyses and expert opinions in district heating pipeline construction. Geotechnical investigations according to DIN 4020; Baugrunduntersuchungen und Baugrundgutachten im Fernwaermeleitungsbau. Geotechnische Untersuchungen nach DIN 4020

    Energy Technology Data Exchange (ETDEWEB)

    Weidlich, Ingo [AGFW Energieeffizienzverband fuer Waerme, Kaelte und KWK e.V., Frankfurt am Main (Germany)

    2010-12-15

    During construction of district heating pipelines, the specifications of the pertinent technical rules must be observed in order to ensure regular construction and to prevent damage. In principle, analyses of the building ground are required depending on the construction project and the pertinent DIN standards. The author lists the standards that are relevant for geotechnical operation, makes an evaluation of these standards, and explains their relevance in the construction of district heating pipelines. (orig.)

  13. Upper limiting operating temperatures of plastic jacket tubes according to EN 253 / FW 401; Obergrenze der Betriebstemperaturen fuer KMR nach EN 253 / FW 401

    Energy Technology Data Exchange (ETDEWEB)

    Besier, Rolf [AGFW - Der Energieeffizienzverband fuer Waerme, Kaelte und KWK e. V., Frankfurt am Main (Germany)

    2010-01-15

    Recent research findings show that ageing of plastic jacket tubes is influenced not only by temperature but also by oxidative processes and in some cases also by mechanical stresses. The author presents current research findings and makes recommendations for optimum temperature conditions to ensure a long service life of plastic jacket tubes. (orig.)

  14. Japan's energy sector beyond Fukushima. What direction for a sustainable energy future?; Japans Energiesektor nach Fukushima. Welche nachhaltige Energiezukunft ist moeglich?

    Energy Technology Data Exchange (ETDEWEB)

    Feldhoff, Thomas [Frankfurt Univ., Frankfurt am Main (Germany). Inst. fuer Humangeographie (IHG) und Interdisziplinaeres Zentrum fuer Ostasienstudien (IZO)

    2013-03-15

    The 11 March 2011 Fukushima nuclear power plant disaster will create long-term challenges for Japans energy security. Energy shortage is a major threat because all facets of the archipelago's economy and society are dependent upon reliable energy supply. Within this context and based on a historical institutionalist approach, this paper reflects on the long-term implications of the disaster for Japan's post-Fukushima energy policies. It argues that institutional change is incremental and path dependent for four major reasons: the massive costs of a major move to alternative energy sources; the rising importance of emission reduction and climate change mitigation policies; vested interests in the status quo of a centralised large-scale energy supply system; and the massive increase in resource nationalism in East Asia as a result of continuing geopolitical tensions. However, promoting energy efficiency, encouraging energy-saving behaviour and focusing on decentralized renewable energy development could help to reduce Japan's energy vulnerability.

  15. Nuclear atlas. After Chernobyl: Nuclear energy between fear and hope. Figures - facts - background information. Der Atomatlas. Nach Tschernobyl: Kernenergie zwischen Angst und Hoffnung. Zahlen - Fakten - Hintergruende

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, M.; Schmidt, A.

    1986-01-01

    Chernobyl has become the catchword that reveals the profound difference of opinions among experts and the population on the issue of nuclear energy. In the many discussions in the public media and elsewhere after the Chernobyl accident, technical terms and scientific terminology and analytic data have been used that induced a feeling of helplessness in the general public, simply because people are not familiar with this terminology and subject. What does 'radioactivity' really mean. What damage to health is done by ionizing radiation. Who finds his way through the muddle of measuring units for radiation, such as rem, Becquerel, or Curie. How does a nuclear power plant work. What kind of reactors are operating in Europe. How safe are they. Where are they. What is a reprocessing plant. These are only a few of the many questions the book answers. The information is intended for the general reader, and supplemented by numerous illustrations, maps, tables and graphs.

  16. Analyse der Preiselastizitäten der Nachfrage nach Biolebensmitteln unter Berücksichtigung nicht direkt preisrelevanten Verhaltens der Verbraucher

    OpenAIRE

    Schröck, Rebecca

    2013-01-01

    Der Biomarkt ist mit einem Umsatzanteil von rund 3,7 % ein kleines Marktsegment im deutschen Lebensmittelmarkt – allerdings mit großem Nachfrage- und Wachstumspotential. Doch wie steht es um die Zahlungsbereitschaft der Biokäufer? Wie reagieren sie auf Preis- und Einkommensänderungen? Gibt es Unterschiede in der Preissensibilität der Konsumenten zwischen verschiedenen Warengruppen? Und inwiefern unterscheidet sich das Nachfrageverhalten verschiedener Konsumentengruppen? Diesen Fragen wurde im...

  17. Levels of concern for radioactive contaminations in soil according to soil protection standards; Besorgniswerte fuer Radionuklide in Boeden nach bodenschutzrechtlichen Massstaeben

    Energy Technology Data Exchange (ETDEWEB)

    Gellermann, R. [Nuclear Control and Consulting GmbH, Braunschweig (Germany); Barkowski, D.; Machtolf, M. [IFUA-Projekt-GmbH Bielefeld (Germany)

    2016-07-01

    In the paper the question is examined whether the established soil protection standards for carcinogenic substances are also applicable to the assessment of radioactive soil contamination. Referring to the methods applied in soil protection for evaluation of dose-effectrelations and estimations of carcinogenic risks as well as the calculation methods for test values in soil protection ''levels of concern'' for soil contamination by artificial radionuclides are derived. The values obtained are significantly larger than the values for unrestricted clearance of ground according to the German Radiation Protection Ordinance (StrlSchV). The thesis that soil is protected according to environmental standards provided that radiation protection requirements are met needs further checks but can be probably confirmed if the radiation protection requirements are clearly defined.

  18. Messung der Leistungsfähigkeit mit der AGARD-STRES-Battery nach partiellem Schlafentzug im Vergleich zu Alkohol und Hypoxie

    OpenAIRE

    Gür, Okan

    2011-01-01

    The DLR Institute of Aerospace Medicine evaluated pilots’ sleep pattern on long-haul flights. Several field studies revealed a shortened sleep duration, which was one part, caused by crossing time zones and the consequent jet-lag the other by short and unfavorable layover times. Similar field studies were carried out on helicopter pilots occupied in air ambulance services. They showed significantly shorter sleep durations during the days of work than in leisure time. However short sleep dura...

  19. Iran, the bomb and the pursuit of security. Structured conflict analyses; Iran, die Bombe und das Streben nach Sicherheit. Strukturierte Konfliktanalysen

    Energy Technology Data Exchange (ETDEWEB)

    Bock, Andreas M. [Akkon-Hochschule fuer Humanwissenschaften, Berlin (Germany); Henneberg, Ingo (ed.) [Freiburg Univ. (Germany). Professur fuer Governance in Mehrebenensystemen

    2014-07-01

    This volume introduces readers to the structured conflict analysis as a tool of social science research and uses this instrument exemplarily to analyze systematically and on a broad basis the various conflicts that are associated with Iran both domestically and in foreign policy - beyond popular stereotypes such as the ''bomb''. The 13 contributions draw a complex picture of the conflicts with and in Iran and reflect the various aspects of these conflicts from different perspectives and at a high methodological and theoretical level. The nuclear program is examined, inter alia through the eyes of four major theories of International Relations. In addition, the analyses are concerned with the regional security dimension, the relationship USA-Iran, the role of national preferences, and the effect of national processes to the Iranian foreign policy.

  20. The German ''Energiewende''. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-12-15

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German ''Energiewende''. The result is clear-cut: The German ''Energiewende'' is inadequate. Due to the cap-and-trade system of the EU the ''Energiewende'' can in no way contribute to climate protection.

  1. Length change of the alloys Waspaloy and Inconel 718 after long-term annealing; Laengenaenderung der Legierungen Waspaloy und Inconel 718 nach Langzeitauslagerung

    Energy Technology Data Exchange (ETDEWEB)

    Kinzel, Svenja

    2016-07-01

    Within the scope of this work the contraction behavior of Ni-based superalloy Waspaloy could in detail be referred to a combination of different microstructural changes and the results could partially be transferred to Ni-Fe-based alloy Inconel 718. Isothermal annealing of sample rods at temperatures between 450 C and 750 C induces an average relative length contraction of about -2.10{sup -4}. It is apparent that contraction is more pronounced for lower temperatures (-3.10{sup -4} at 550 C) than for higher ones (-1.10{sup -4} at 750 C). Within the first 300 hours of annealing the contraction reaches about 70-75% of the value measured after 10,000 hours. This means the major part of the effect takes place at the beginning of long term annealing but even after 10,000 hours no saturation occurs. On the basis of lattice parameter measurements it could be found that within the first 300 hours a significant lattice parameter decrease of matrix and γ{sup '} phase emerged. Longer annealing time does not cause further lattice contraction. This sample behavior can be explained by temperature dependence of phase fractions and phase compositions. Thermodynamic calculations as well as stereological analysis of micrographs show a decrease of stable γ{sup '}-phase content with increasing temperature. In parallel, TEM-EDS measurements and calculated phase fractions show concentration fluctuations due to the different precipitate fraction, which cause contraction of the lattice parameter. Furthermore, within the first 100 hours at temperatures up to 650 C the formation or Ni-Cr rich domains could be observed. As these domains exhibit a smaller lattice parameter than the matrix they contribute to the more pronounced contraction at lower temperatures. While XRD measurements point to the formation of Ni{sub 3}Cr, TEM-EDS measurements reveal a composition of (Ni,Co){sub 2}Cr. Stress relief heat treatment at higher temperatures (815 C) after annealing shows that the effect of contraction is reversible. It causes an increase in lattice parameter and the Ni-Cr domains formed at lower temperatures are dissolved by the influence of higher temperatures. The sample elongation caused by stress relief heat treatment therefore is more pronounced for samples annealed at lower temperatures. The combination of lattice parameter change and formation of Ni-Cr rich domains explains the sample behavior within the first 300 hours. The further, slowly proceeding contraction for longer annealing times refers to carbide transformation. Particles of TiC and Ti(N,C) slowly dissolve in a peritectic reaction. An extrapolation of the results shows that complete dissolution will be reached after 14,000,000 hours (= 1,600 years). Dissolution of these phases leads to sample contraction reaching values of about -4,0.10{sup -4} after 10,000 hours. A contrary effect is caused by the concurrent formation of Cr{sub 23}C{sub 6}, which consumes the free C-atoms from carbide dissolution. Formation of this carbide type with 1.4% volume fraction is finished after 16,000,000 h (= 1,800 years). Within 10,000 h the phase formation leads to sample elongation of about +3,4.10{sup -4}. The combination of both effects almost cancels out and therefore only causes contraction of about -0,6.10{sup -4}, which is about 30% of the measured contraction. When the carbide transformation is complete, no further length change is expected. Although conditions are more complicated for alloy Inconel 718 due to the presence of additional phases (γ'' und δ-phase) the results can transferred in principal. The measured sample contraction is lower than for Waspaloy. Within the investigated temperature range the calculated phase diagram shows significant changes only for the phase fraction of γ{sup '} phase. As volume fraction of γ{sup '} precipitates is small (<10%) for Inconel 718, the compositional fluctuations caused by its dissolution are low. The measured length contraction at 450 C and 550 C therefore is only about -1,3.10{sup -4}. Temperatures of 650 C and above lead to formation of δ phase, which enhances the contraction to -2,6.10{sup -4} for standard heat treated samples. The reason for the lower impact of this effect for short-term heat treated sample could not fully be resolved in this work. A detailed investigation of the influence of γ'' phase an intense use of TEM techniques is necessary. Additionally, alloy Inconel 718 also shows low phase fractions of carbides and carbonitrides. Dissolution of (Ti,Nb)(C,N) has a bigger impact on contraction but is nearly stable while a slight decrease in (Nb,Ti)C content is measured. This causes a contraction of -0,6.10{sup -4}, which is way smaller than contraction caused by carbide dissolution in Waspaloy. This contributes to the reason, why overall contraction of Inconel 718 is less pronounced. The combination of several microstructural changes comprehensively explains the effect of contraction of Ni-based superalloys. The major part of the effect is caused by lattice parameter changes due to temperature dependent changes in stable phase fractions and compositions. The further minor contraction is referred to carbide transformation process.

  2. Hämodynamik bei Patienten mit idiopathischem Vorhofflimmern nach Kardioversion in den Sinusrhythmus : hämodynamische Effekte unter Rezidivprophylaxe mit Sotalol, Cordichin und Amiodaron

    OpenAIRE

    Lehinant, Stefan André

    2005-01-01

    Vorhofflimmern ist die in der Klinik und Praxis am häufigsten diagnostizierte Herzrhythmusstörung. In allen Fällen bestehen zwei grundsätzliche Therapieoptionen: Zum einen Kardioversionsbehandlung gefolgt von Rezidivprophylaxe mit Antiarrhythmika bzw. alleinige Frequenzkontrolle unter adäquater Antikoagulation bei Inkaufnahme der Rhythmusstörung. In der vorliegenden Arbeit sind 32 Patienten mit persistierendem Vorhofflimmern untersucht worden, die entwedermit Cordichin, Sotalol oder Amiodaron...

  3. Changes in equipment and image quality. Impact of one year Austrian breast cancer early detection programme; Aenderungen in der Geraetelandschaft und Bildqualitaet. Auswirkungen nach einem Jahr Oesterreichischem Brustkrebsfrueherkennungsprogramm

    Energy Technology Data Exchange (ETDEWEB)

    Menhart, S.; Osanna-Elliott, A.; Semturs, F.; Schloegl, C.; Wildner, S.; Zwettler, G. [AGES, Wien (Austria). Referenzzentrum fuer technische Qualitaetssicherung im Brustkrebsfrueherkennungsprogramm

    2015-07-01

    The nationwide Austrian Breast Cancer Early Detection Programme (''BKFP'') started in January 2014. The Austrian Agency for Health and Food Safety Ltd. was entrusted with running the reference center for technical quality control (''RefZQS'') on April 1, 2014. The quality of the radiologists' equipment is evaluated against the standards described in the EUREF-Oeprotocol, which is based on the European guidelines for quality assurance in breast cancer screening and diagnosis (EPQC V4, 2006) and has been optimized for Austrian requirements. In its first year of operation the RefZQS has controlled the entire equipment (mammography, periphery and ultrasound system) of all participating radiologists. A significant number of systems had to be adjusted to meet the EUREF-Oecriteria. Some of the systems could not be adjusted accordingly, and had to be replaced. In the wake of the start of the screening programme, several sites switched from CR to more modern DR systems, yielding a significant benefit by reduction of radiation burden. The most important data after one year of RefZQS, especially according to adjustments and replacements, are presented.

  4. Auf der Suche nach dem wahren Selbst. Feminismus, Schönheit und Kosmetikindustrie in der Bundesrepublik seit den 1970er-Jahren

    Directory of Open Access Journals (Sweden)

    Uta G. Poiger

    2017-08-01

    Full Text Available In evaluating beauty and cosmetics, feminists have developed different concepts of the ›self‹ since the 1970s, often in friction with the advertising strategies of the cosmetics industry. Alternative magazines like Courage and Emma offered important forums for such exchanges. In feminist critiques of beauty ideals and cosmetics, the articulation of a true or authentic self was important, and yet was regularly questioned, especially in feminist appropriations of punk. From the 1980s onwards, the concept of an entrepreneurial self has become increasingly evident in discussions of beauty and cosmetics; this entrepreneurial self uses cosmetics in specific contexts to present a versatile, self-assured subject. Working with the concept of vernacular ethnology – a method of rapid general cultural comparison which can be found in feminist analyses as well as in global advertising campaigns of the cosmetics industry – the essay examines how an understanding of alleged ethnic differences has contributed to these developments. In the twenty-first century, people (men included perform their ›beauty work‹ in the context of ambiguous conceptualizations of beauty, which is regarded as being at once attainable, oppressive and liberating. * * * Feministinnen haben seit den 1970er-Jahren im Umgang mit Schönheit und Kosmetik unterschiedliche Konzeptionen des »Selbst« entwickelt, oft sich an den Werbestrategien der Kosmetikindustrie reibend. Zeitschriften wie »Courage« und »Emma« boten dafür wichtige Foren. In der feministischen Kritik von Schönheitsidealen und Kosmetik war die Artikulation eines wahren Selbst wichtig und wurde zugleich immer wieder hinterfragt, besonders in feministischen Aneignungen des Punk. Ab den 1980er-Jahren wurde im Verständnis von Schönheit und Kosmetik zunehmend die Konzeption eines unternehmerischen Selbst deutlich, das Kosmetika situationsbedingt zur Darstellung eines flexiblen, selbstbewussten Subjekts einsetzt. Ausgehend von Topoi einer volkstümlichen Ethnologie – einem Verfahren des schnellen allgemeinen Kulturvergleichs, das sich in feministischen Analysen finden lässt, aber auch in globalen Werbekampagnen der Kosmetikindustrie – untersucht der Aufsatz, inwieweit das Verständnis von angeblichen ethnischen Unterschieden diese Entwicklungen mitgeprägt hat. Im 21. Jahrhundert leisten Menschen (auch Männer ihre »Schönheitsarbeit« im Kontext ambivalenter Analysen von Schönheit – die als erreichbar, unterdrückend und befreiend zugleich gilt.

  5. Battery recycling: the return rate must still grow. Batrec AG now working after initial difficulties. Batterierecycling: der Ruecklauf muss noch wachsen. Die Batrec AG funktioniert nach anfaenglichen Startschwierigkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1994-11-11

    There is a battery disposal self-help organisation (BESO) in Switzerland which collects a voluntary advance disposal fee (VEG) from the manufacturer or importer in order to finance the disposal of batteries via the recycling infrastructure. The fee is determined by three factors: disposal cost per ton; return rate; and individual battery weight. Thus the VEG is 5 rappen for zinc-carbon batteries and 10 rappen for alkali-manganese batteries. In 1993 90% (in terms of weight) of all batteries sold on the market made a VEG contribution to the BESO fund. The return rate for used batteries rose from 54% in 1992 to over 60% in 1993. In 1992 Batrec cooperated with Sumitomo Heavy Industries in the construction of the world's first industrial battery recycling plant. After initial difficulties Batrec is now processing 160 tons of used batteries per month. The recovered metals sell readily due to their high quality. (MM)

  6. The characteristic features of the German and the U. S. American law governing the licensing of nuclear installations. Genehmigung kerntechnischer Anlagen nach deutschem und US-amerikanischem Recht

    Energy Technology Data Exchange (ETDEWEB)

    Heitsch, C.

    1993-01-01

    The author's comparative analysis of the German and the U.S. American legislation is intended to exhibit the specific structures of the two regulatory systems, and their performance regarding the intended purpose of providing the best possible protection against the risks posed by nuclear energy. It is further analysed whether instruments or structures of the U.S. American law can be adopted by the German law and applied to solving problems arising in Germany. In the selfcontained review of the German Atomic Energy Act and the nuclear licensing provisions, emphasis is placed on the development of judicial control in Germany, as the court decisions have a major impact on accepted practice in Germany. This is followed by a self-contained review of the licensing procedure in the U.S.A., with a focus on the right to be heard of the general public, and on the system of rulemaking powers by the state commissions and agencies. The author finally explains the most significant differences of the two regulatory systems and draws some conclusions as to the underlying legal policy. A concluding analysis examines the question of whether the recent judgments by the Federal Administrative Court, relating to judicial control and the binding effect of substantiating administrative regulations, are justifiable from the dogmative point of views. (orig.)

  7. Imaging of scaphoid fractures according to the new S3 guidelines; Bildgebende Diagnostik der Skaphoidfrakturen nach den aktuellen S3-Leitlinien

    Energy Technology Data Exchange (ETDEWEB)

    Schmitt, R. [Cardiovascular Center, Bad Neustadt an der Saale (Germany). Diagnostic and Interventional Radiology; Rosenthal, H. [KRH Hospital Siloah-Oststadt-Heidehaus, Hannover (Germany). Diagnostic and Interventional Radiology

    2016-05-15

    Up to 30 % of acute scaphoid fractures are missed in conventional radiography. CT and MRI should be early performed in the diagnostic workflow, when radiograms (dorsopalmar, lateral and Stecher's views) are negative or inconclusive in fracture detection. Significance of CT is different from that of MRI: Sensitivity of CT imaging (85 to 95 %) is superior to conventional radiography (about 70 %), but inferior to MRI (almost 100 %). However, CT (specificity 95 to 100 %) is able to provide more detailed anatomic information of the fracture pattern when compared to MRI (specificity 80 to 90 %). Particularly, differentiation of bone contusion ('bone bruise') and non-displaced fracture can be difficult in MRI. Thus, CT indication is not only given for fracture detection, but also for assessing the morphology in scaphoid fractures (localization, fragment dislocation, comminuted zones) and the fragment instability, too. MRI should be limited to equivocal trauma cases presenting pain in the snuff box, but with inconclusive CT findings. In CT and MRI of scaphoid fractures, image display must be aligned along the longitudinal extension of the scaphoid, either by acquiring or reformatting oblique-sagittal and oblique-coronal planes.

  8. Gazprom has ambitions in the Far East. Russia's natural gas producer looks towards Japan; Gazprom hegt Ambitionen in Fernost. Russischer Erdgasfoerderer blickt nach Japan

    Energy Technology Data Exchange (ETDEWEB)

    Bollinger-Kanne, Josephine

    2012-11-12

    There are enormous reserves of natural gas in the Russian iciness in the far north of Siberia. The gas company Gazprom (Moscow, Russia) transports these stocks via a pipeline and by ship to Europe and to the Far East. The reactor accident at Fukushima and the subsequent shutdown of all nuclear power plants in Japan in May 2012 inspired the Russian ambitions to establish itself as a key supplier of energy in the Pacific.

  9. Linguistik als Kampfsport – Ein Plädoyer für die Suche nach Paradigmen demokratischen Sprechens in Alltag, Medien und Recht

    Directory of Open Access Journals (Sweden)

    Friedemann Vogel

    2014-12-01

    Full Text Available Following Bourdieu's notion of applied research this contribution asks for the possibility of linguistics as a kind of "martial art" and "self-defence", i. e. linguistics trying to interfere in society based on a holistic model of human rights and paradigms of democratic speech. In this perspective the text discusses elements of a normative model, which is able to lead linguistic research practices and explores the context of education, law and the media formation of par-ticipation. Finally I will consider the meaning of speech practices and linguistic research or methods in the context of capitalism and profit.

  10. Arbeitsmigration aus Drittstaaten nach Deutschland – ein Überblick über das aktuelle System, Einwandererzahlen und Hauptherkunftsländer

    OpenAIRE

    Oesingmann, Katrin

    2016-01-01

    Die Förderung der Zuwanderung qualifizierter Arbeitskräfte aus dem Ausland gehört zu den Maßnahmen der westlichen Industrienationen zur Sicherung des Fachkräftebestandes. Bisher zeigt sich jedoch, dass sowohl Deutschland als auch die EU im Vergleich zu anderen Industrienationen insgesamt nicht sehr erfolgreich bei der Anwerbung von (hoch-)qualifizierten Migranten sind.

  11. Grid connection point according to EEG. Does the BHG succeed the clearing house?; Netzverknuepfungspunkt nach dem EEG. Folgt der BGH der Clearingstelle?

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Jochen; Neusuess, Peter [Gassner, Groth, Siederer und Coll., Berlin (Germany). Bereich Anlagenzulassungs- und Energierecht

    2012-02-15

    Since the introduction of the Renewable Energy Law (EEG) in the year 2000, there is a dispute at which point a network operator has to connect an EEG system to his power distribution system. An explicit regulation on the network connection point first was made by the legislator in paragraph 5 EEG 2009. Due to the surprising recommendation of the Clearing House at the end of September 2011, the conflict opened again. At the Federal Court of Justice (Karlsruhe, Federal Republic of Germany), three proceedings are pending on this issue. Until the Federal Court of Justice has decided one of these three proceedings, the plant operator must assess the legal situation on the basis of previous decisions. With this in mind, the authors of the contribution under consideration report on the argumentation of the decisions and on the possibilities to handle the current situation.

  12. The privilege of producing the own electricity according to paragraph 37 sect. 3 EEG 2012; Das Eigenstromerzeugerprivileg nach paragraph 37 Abs. 3 EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Hilgers, Hans Anton [Deutscher Bundestag, Berlin (Germany). Bundestagsverwaltung

    2012-02-15

    With the use of the new privilege of private power gegeneration according to paragraph 37 section 3, No. 2b EEG 2012, it is not important who is the owner of the power plant or a power generation plant. However, it is absolutely necessary that the company that uses the electric current, also produces this electric current. For this purpose useful criteria have been developed. In this case, the end consuming juridical person is regarded as a power generator. Furthermore, it is absolutely necessary that the generation of own power takes place in the spatial context of the consumption of own electricity by non-public networks by the same legal person. In particular, contracting models are likely to fail in this.

  13. Provision of regulating energy in the context of direct marketing according to the EEG 2012; Zur Bereitstellung von Regelleistung im Rahmen der Direktvermarktung nach dem EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Breuer, Daniel [Landgericht Koeln (Germany); Osborne Clarke, Koeln (Germany)

    2012-07-01

    Electric power from wind power plants and photovoltaic power plants cannot be stored and is not available at all times. The results are volatile power supply curves, risks of availability forecasting for grid owners or (direct) marketers, and enhanced requirements on grid operation with stable frequency. All this will directly affect the reliability of power supply in Germany. Grid integration and market integration of renewable energy sources are directly connected. The contribution discusses the challenges of ensuring grid stability as well as the legal regulations governing the supply of regulating power from renewable energy sources. Since 1 January 2012, regulating power from renewable energy sources is provided within the scope of the EEG only by direct marketing, i.e. without receiving fixed reimbursement rates. Direct marketing is only possible outside the scope of the EEG, but this is without relevance for the time being. (orig.)

  14. Higher efficiency, lower bonuses. Financial incentives for power from biomass according to EEG 2012; Mehr Effizienz, weniger Boni. Die Foerderung von Strom aus Biomasse nach dem EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Dominik [Ecologic Institute, Berlin (Germany)

    2012-07-01

    The German parliament passed a total of eight new laws for the intended energy turnaround. Apart from changes in atomic law, the focus was on a complete amendment of the Renewables Act (EEG). The contribution outlines the new regulations for power generation from biomass from 2012. It indicates the changes from former regulations and describes the structural changes required for sustainable power supply from biomass, among others.

  15. „Besuch&Buch“: Soziale Bibliotheksarbeit der Stadtbibliothek Graz nach dem Vorbild der „Medienboten“ (Hamburg im Blickfeld der Gerontologie

    Directory of Open Access Journals (Sweden)

    Burkert, Petra

    2016-12-01

    Full Text Available In 2013 the Public Library of Graz launched a home library service which is unique in Austria up to today: volunteer book messengers visit senior and homebound citizens at their homes. “Besuch&Buch” has been inspired by the “Medienboten”, a socio-cultural project started by Hamburg Public Libraries in 2007. The author – librarian and gerontologist in Graz – has written her master thesis on “Besuch&Buch” and describes why library social projects as “Besuch&Buch” have never been more important than in today’s demographic change.

  16. Evaluation and optimization of groundwater protection programs according to EU-Water framework directive; Bewertung und Optimierung von Grundwasserschutz-Massnahmenprogrammen nach der EU-Wasserrahmenrichtlinie

    Energy Technology Data Exchange (ETDEWEB)

    Kuhr, Petra; Kunkel, Ralf; Wendland, Frank [Forschungszentrum Juelich GmbH (DE). Inst. fuer Chemie und Dynamik der Geosphaere (ICG) - Inst. 4: Agrosphaere; Baron, Ute; Voigt, Hans-Juergen [Technische Univ. Cottbus (Germany). Lehrstuhl fuer Umweltgeologie

    2011-03-15

    In order to evaluate and optimize programmes of measures according to EU-Water framework directive a methodology has been developed which consists of three consecutive parts. In the first part the interrelations between matter inputs (contaminations), observed matter concentrations in groundwater and the hydrogeological system are analyzed based on a ''conceptual model''. Based on this a consistent evaluation of the extent of pollutant reduction necessary to reach good status of groundwater is carried out in the second part. The third part is an evaluation of the time gap between the introduction of a measure and its impact on the status of groundwater. The derived methodology is predominately based on digital datasets as input data which are available on the level of Germany's Federal States. Adapted to the sources of contamination of groundwater the methodology was successfully tested for diffuse nitrate sources in two regions in Lower Saxony/Northrhine-Westfalia and Hesse and for point sources in one region in Brandenburg. (orig.)

  17. Das Re-entry von Kritik: Assemblageforschung nach der Kritik an der Kritik. Kommentar zu Alexa Färbers „Potenziale freisetzen“

    Directory of Open Access Journals (Sweden)

    Hanna Göbel

    2014-05-01

    Full Text Available Der Kommentar zum Beitrag von Alexa Färber diskutiert eine Vermengung von drei unterschiedlichen Kritikbegriffen sowie Orten von Kritik in der aktuellen Debatte um die Assemblageforschung im Feld der Urban Studies. Ich rekonstruiere und unterscheide zwischen einem Kritikbegriff als theoretischer Norm, wie er von der (neo-marxistischen Stadt- und Raumforschung vertreten wird, und der ontologischen Kritik dieser Norm seitens der Assemblageforscher_innen. Alexa Färbers Beitrag zeigt drittens exemplarisch eine sich einschleichende normative Ebene in der Assemblageforschung auf, die bislang als Kritikform unterbelichtet geblieben ist. Diese wird als Wiedereinführung (re-entry von empirisch vollzogener Kritik in die Assemblageforschung bezeichnet. Damit ist eine theoretische Neupositionierung von Kritik ‚innerhalb’ einer Assemblage gemeint, indem Kritik nicht mehr als theoretische Norm ‚außerhalb’ zu verorten ist. In diesem Kommentar plädiere ich dafür, in der Assemblageforschung eine differenzierte Auseinandersetzung mit unterschiedlichen Begriffen und Orten von Kritik zu pflegen, um innerhalb der Urban Studies und für interessierte städtische Akteure mit urbaner Expertise (u.a. Architekt_innen, Planer_innen, Künstler_innen, Aktivist_innen, Kultur- und Sozialarbeiter_innen, DIY-Gemeinschaften klarer adressierbar zu sein.

  18. Go west : internal migration in Germany after reunification Go West : interregionale Migration in Deutschland nach der Wiedervereinigung

    Directory of Open Access Journals (Sweden)

    Birgit Glorius

    2012-12-01

    Full Text Available The paper wants to shed light on the phenomenon of internal migration in Germany after the fall of the iron curtain. Since German reunification, the eastern part of Germany lost a large share of its population due to internal migration. Whereas in the beginning, departures were spread evenly over all age and educational groups and were accompanied by a significant counter-stream, in the course of time the negative migration balance was mainly produced by younger people at the beginning of their professional career. The paper describes the development of internal east-west migration in detail and presents primary data on the profiles of young migrants drawn from a research project during the years 2004-2007 (in this research project, financed by the German Research Foundation DFG, data were gathered from 1,200 migrants aged between 18-35 who moved from the federal state Sachsen-Anhalt to the western part of Germany. Hereby, special emphasis will be given to the methodological implications of studying selective migration processes. Final conclusions are drawn regarding the regional assessment and theoretical classification of this migration process, but also on the theoretical and methodological constraints of mobility research.Seit der deutschen Wiedervereinigung hat Ostdeutschland beträchtliche Bevölkerungs­verluste aufgrund von innerdeutschen Wanderungen zu verzeichnen. Während der Migrationsstrom zunächst relativ gleichmäßig über alle Bevölkerungsgruppen hinsichtlich Alter und Bildungsstand verteilt war und überdies von einem signifikanten Gegenstrom begleitet wurde, hat er sich im Laufe der 1990er Jahre ausdifferenziert. Die negative Wanderungsbilanz ist heute vor allem durch die Abwanderung junger Menschen zu Beginn des Erwerbslebens gekennzeichnet. Der Beitrag bietet eine detaillierte Beschreibung der innerdeutschen Ost-West-Wanderung und präsentiert empirische Primärdaten zu den Profilen junger Ost-West-Migranten aus Sachsen-Anhalt (die Daten stammen aus einer durch die Deutsche Forschungsgemeinschaft DFG finanzierten Studie zur innerdeutschen Ost-West-Wanderung, die 1.200 junge Abwanderer zwischen 18 und 35 Jahren umfasste. Die abschließende Generalisierung gibt Hinweise bezüglich der spezifischen geographischen Kompetenzen – aber auch der Fallstricke – im Bereich der internationalen und intra-nationalen Migrationsforschung.

  19. Costs and role of ultrasound follow-up of polytrauma patients after initial computed tomography; Kosten und Stellenwert von Ultraschallverlaufskontrollen bei polytraumatisierten Patienten nach initialer Computertomografie

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, M.H.; Winkler, A.; Powerski, M.J.; Elgeti, F.; Huppertz, A.; Roettgen, R.; Marnitz, T. [Charite - Universitaetsmedizin Berlin (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Wichlas, F. [Charite - Universitaetsmedizin Berlin (Germany). Centrum fuer Muskuloskeletale Chirurgie

    2012-01-15

    Purpose: To assess the costs and diagnostic gain of abdominal ultrasound follow-up of polytrauma patients initially examined by whole-body computed tomography (CT). Materials and Methods: A total of 176 patients with suspected multiple trauma (126 men, 50 women; age 43.5 {+-} 17.4 years) were retrospectively analyzed with regard to supplementary and new findings obtained by ultrasound follow-up compared with the results of exploratory FAST (focused assessment with sonography for trauma) at admission and the findings of whole-body CT. A process model was used to document the staff, materials, and total costs of the ultrasound follow-up examinations. Results: FAST yielded 26 abdominal findings (organ injury and/or free intra-abdominal fluid) in 19 patients, while the abdominal scan of whole-body CT revealed 32 findings in 25 patients. FAST had 81 % sensitivity and 100 % specificity. Follow-up ultrasound examinations revealed new findings in 2 of the 25 patients with abdominal injuries detected with initial CT. In the 151 patients without abdominal injuries in the initial CT scan, ultrasound follow-up did not yield any supplementary or new findings. The total costs of an ultrasound follow-up examination were EUR 28.93. The total costs of all follow-up ultrasound examinations performed in the study population were EUR 5658.23. Conclusion: Follow-up abdominal ultrasound yields only a low overall diagnostic gain in polytrauma patients in whom initial CT fails to detect any abdominal injuries but incurs high personnel expenses for radiological departments. (orig.)

  20. The German ''Energiewende''. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German ''Energiewende''. The result is clear-cut: The German ''Energiewende'' is inadequate. Due to the cap-and-trade system of the EU the '''Energiewende''.

  1. Relationship between internal dosimetry and DNA double strand breaks in lymphocytes after radionuclide therapy; Zusammenhang zwischen physikalischer Dosimetrie und DNA Doppelstrangbruechen in Lymphozyten nach Radionuklidtherapie

    Energy Technology Data Exchange (ETDEWEB)

    Eberlein, Uta

    2015-09-30

    In radionuclide therapy radiopharmaceuticals are administered mostly systemically. Primarily, beta-emitters are used because of their short range in tissue. As a result the radiopharmaceutical distributes within the human body and accumulates in organs and target structures. Thus, the body is irradiated internally, in contrast to external irradiation in radiotherapy. The pattern of the activity distribution within the human body is determined by the physical and chemical properties of the radiopharmaceutical. Furthermore, the amount of activity and its accumulation in organs or tissues is essential for the calculation of the absorbed dose which defines the energy deposited in the body by ionizing radiation. During internal or external irradiation, patients are exposed to ionizing radiation which does not only destroy the malignant cells but also damages healthy tissue and cells. This is mainly caused by direct and indirect interaction of the radiation with the DNA which damages the DNA structure. Most frequently, there are single strand breaks and base damages. DNA double strand breaks (DSBs) are rare; nevertheless, they are the most critical lesions for cells as repairing the damage is difficult. Unrepaired or misrepaired DNA could cause mutations, chromosomal aberrations or lead to cell death. The formation of a DNA DSB in nuclear chromatin results in the rapid phosphorylation of the histone H2 variant H2AX, then called gamma-H2AX. Furthermore, DSBs also recruit the damage sensor 53BP1 to the chromatin surrounding the DSBs, which leads to 53BP1 and gamma-H2AX co-localization in the chromatin surrounding a DSB. By immunofluorescence staining with gamma-H2AX and 53BP1 antibodies those biomarkers can be addressed by microscopically visible DNA damage protein foci, this is also known as the DNA damage focus assay. With progression of DSB repair, gamma-H2AX and 53BP1 foci disappear. It is assumed that one focus corresponds to one DSB. Therefore, the number of foci per cell can be used as a quantitative biomarker for DNA double strand breaks and hence for radiation exposure and radiation effects. Most studies dealing with the DNA damage focus assay performed in the last years were looking only on the effect of external irradiation after external radiation therapy or after diagnostic radiology procedures, but only few with the effects after administration of radiopharmaceuticals. Therefore, the aims of this thesis were: 1. To develop a method to generate an in-vitro calibration curve for the DSB focus assay after internal irradiation with beta-emitting radionuclides by creating a low dose and low dose-rate blood irradiation situation in-vitro, at dose-rates that are similar to the ones that have been observed in nuclear medicine patients. 2. To determine the absorbed dose and the number of radiation-induced foci in lymphocytes by sampling blood from patients after radiopeptide therapy with Lu-177 and radioiodine therapy with I-131. 3. To describe comprehensively the temporal and dose-dependent behavior of the DNA damage focus assay in radiation treatment-naive patients after their first radionuclide therapy using the results of the in-vitro calibration. For the in-vitro calibration with I-131 and Lu-177 blood samples For the in-vitro calibration with I-131 and Lu-177 blood samples were drawn from volunteers. Different activity concentrations were added to the samples for achieving absorbed doses up to 100mGy. As a result it was shown that the number of radiation-induced foci were linearly dependent of the absorbed dose. This is the same result that has been shown after external irradiation. The patient studies addressed the relationship between the absorbed dose to the blood and the number and temporal behavior of radiation-induced DNA double strand breaks in peripheral blood samples under radiopeptide therapy and under radioiodine therapy. The average number of radiation-induced foci showed a linear dose-response relationship within the first hours after administration of the radiopharmaceutical. The slope of the in-vitro calibration curve was in good agreement with the slopes of the linear functions fitted to the in-vivo data for Lu-177 and I-131. Later time points were characterized by a diminishing number of radiation-induced foci which was in accordance with the progression of DNA repair and the declining dose rates. Most patients treated with I-131 exceeded 20mGy in the first hour and in these patients the onset of a fast repair component was observed. With the experimental results and model calculations presented in this work, for the first time a dose-response relationship and a description of the time course of the in-vitro and in-vivo damage response after internal irradiation of beta-emitters could be established.

  2. Striated nephrogram as an incidental finding in MRI examination of children; Streifiges Nephrogramm als Zufallsbefund nach Kontrastmittelgabe bei Kindern in der MRT

    Energy Technology Data Exchange (ETDEWEB)

    Strocka, S.; Sorge, I.; Ritter, L.; Hirsch, F.W. [Leipzig Univ. (Germany). Dept. of Pediatric Radiology

    2016-01-15

    A highly striated contrast pattern of the kidneys occasionally appears in abdominal MRI examinations of children following the administration of gadolinium. As this phenomenon is well known but has not yet been explicitly described in literature, we investigated how frequently and in which clinical context this occurred. 855 abdominal MRI examinations with contrast media of 362 children between 2006 and 2014 were analysed retrospectively. A striated renal parenchyma was found in a total of nine children and eleven examinations (1.3 % of examinations) and did only occur at a field strength of 3 Tesla. Of these children, seven had previously had tumors and chemotherapy. In two children there was no evidence of a previously serious condition with medications or a kidney disease. All of them had a normal renal function. A noticeably striated nephrogram in the later phase of an MRI examination following administration of gadolinium may appear as an incidental finding in examinations at 3 Tesla without pathological relevance.

  3. After Fukushima? On the educational and learning theoretical reflection of nuclear disasters. International perspectives; Nach Fukushima? Zur erziehungs- und bildungstheoretischen Reflexion atomarer Katastrophen. Internationale Perspektiven

    Energy Technology Data Exchange (ETDEWEB)

    Wigger, Lothar; Buenger, Carsten (eds.) [Technische Univ. Dortmund (Germany). Bereich Allgemeine Erziehungswissenschaft; Platzer, Barbara [Technische Univ. Dortmund (Germany)

    2017-08-01

    The book on the educational and learning theoretical reflection of nuclear disasters as a consequence of Fukushima includes contributions on the following issues: pedagogical approach: children write on Fukushima, description of the reality as pedagogical challenge; lessons learned on the nuclear technology - perspectives and limits of pedagogical evaluation: moral education - Japanese teaching materials, educational challenges at the universities with respect to nuclear technology and technology impact assessment; education and technology - questions concerning the pedagogical responsibility: considerations on the responsibility of scientists, on the discrepancy between technology and education, disempowerment of the public by structural corruption - nuclear disaster and post-democratic tendencies in Japan.

  4. Volkmar Sigusch: Auf der Suche nach der sexuellen Freiheit. Über Sexualforschung und Politik. Frankfurt am Main u.a.: Campus Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Heike Friauf

    2012-11-01

    Full Text Available Allein die Texte zur Abwicklung des Frankfurter Instituts für Sexualwissenschaft 2006 füllen ein Viertel dieses Sammelbandes. Doch Wundenlecken ist nicht die Sache des Autors und ehemaligen Institutsleiters Volkmar Sigusch, der als einer der renommiertesten Sexualwissenschaftler weltweit gilt. Sein facettenreiches Buch enthält neben zeithistorischen Dokumentationen höchst unterschiedliche, allerdings auch unterschiedlich gut lesbare Artikel zu aktuellen die Sexualität als gesamtgesellschaftliches Phänomen betreffenden Fragen. Es kulminiert in scharfer sexualwissenschaftlich fundierter Gesellschaftskritik.The texts on the closure of the Frankfurt Institute of Sexology in 2006 single-handedly fill a quarter of this anthology. But author and former head of the institute Volkmar Sigusch, who is considered to be one of the world’s most renowned sexologists, is not fond of licking wounds. In addition to contemporary documentaries, his multi-faceted book contains highly diverse (however also diversely readable articles on contemporary questions that relate to sexuality as a phenomenon of society as a whole. It culminates in sharp, sexology-grounded social criticism.

  5. Enhanced casein kinase II activity during mouse embryogenesis. Identification of a 110-kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse ascites tumor cells

    DEFF Research Database (Denmark)

    Schneider, H R; Reichert, G H; Issinger, O G

    1986-01-01

    Mouse embryos at various stages of development were used to study the relationship of protein kinase activities with normal embryogenesis. Casein kinase II (CKII) activity in developing mouse embryos shows a 3-4-fold activity increase at day 12 of gestation. Together with the CKII activity...... mouse tumour cells also show an enhanced CKII activity. Here too, a 110-kDa phosphoprotein was the major phosphoryl acceptor. Partial proteolytic digestion shows that both proteins are identical. Other protein kinases tested (cAMP- and cGMP-dependent protein kinases) only show a basal level of enzyme......, increased phosphorylation of a 110-kDa protein is observed. Treatment of the embryo extracts with heparin, a highly specific inhibitor of CKII activity, results in a drastic reduction of the 110-kDa protein phosphorylation indicating that the protein might be a CKII-specific substrate. Rapidly proliferating...

  6. Comparison of phosphorylation of ribosomal proteins from HeLa and Krebs II ascites-tumour cells by cyclic AMP-dependent and cyclic GMP-dependent protein kinases

    DEFF Research Database (Denmark)

    Issinger, O G; Beier, H; Speichermann, N

    1980-01-01

    identified by two-dimensional gel electrophoresis. Almost identical results were obtained when ribosomal subunits from HeLa or ascites-tumour cells were used. About 50-60% of the total radioactive phosphate incorporated into small-subunit ribosomal proteins by either kinase was associated with protein S6...

  7. 2H2O incorporation into hepatic acetyl-CoA and de novo lipogenesis as measured by Krebs cycle-mediated 2H-enrichment of glutamate and glutamine.

    Science.gov (United States)

    Silva, Ana Maria; Martins, Fatima; Jones, John G; Carvalho, Rui

    2011-12-01

    Deuterated water is widely used for measuring de novo lipogenesis on the basis of quantifying lipid (2)H-enrichment relative to that of body water. However, incorporation of (2)H-enrichment from body water into newly synthesized lipid molecules is incomplete therefore the true lipid precursor enrichment differs from that of body water. We describe a novel measurement of de novo lipogenesis that is based on a true precursor-product analysis of hepatic acetyl-CoA and triglyceride methyl enrichments from deuterated water. After deuterated water administration to seven in situ and seven perfused livers, acetyl-CoA methyl enrichment was inferred from (2)H nuclear magnetic resonance analysis of hepatic glutamate/glutamine (Glx) enrichment and triglyceride methyl enrichment was directly determined by (2)H nuclear magnetic resonance of triglycerides. Acetyl-CoA (2) H-enrichment was 71% ± 1% that of body water for in situ livers and 53% ± 2% of perfusate water for perfused livers. From the ratio of triglyceride-methyl/acetyl-CoA enrichments, fractional de novo lipogenesis rates of 0.97% ± 0.09%/2 hr and 7.92% ± 1.47%/48 hr were obtained for perfused and in situ liver triglycerides, respectively. Our method reveals that acetyl-CoA enrichment is significantly less than body water both for in situ and perfused livers. Furthermore, the difference between acetyl-CoA and body water enrichments is sensitive to the experimental setting. Copyright © 2011 Wiley Periodicals, Inc.

  8. Queere Aneignungen von David und Goliat : Künstlerische Selbstporträts als besiegte Knabenliebhaber

    NARCIS (Netherlands)

    Hügel, K.; Dietrich, W.; Edenburg, C.; Hugo, P.

    2016-01-01

    Die jüdische Rezeption der biblischen Erzählung von Davids Sieg über Goliat liefert homoerotische Neuinterpretationen dieser Geschichte. Das Verhältnis zwischen Goliat und David wird durch eine erotische Linse als Beziehung eines erwachsenen Manns zu einem schönen jungen Mann gelesen. Die

  9. Radiological diagnostics of pediatric lungs; Radiologische Diagnostik der kindlichen Lunge

    Energy Technology Data Exchange (ETDEWEB)

    Beer, M.; Ammann, B. [Universitaetsklinikum Ulm, Klinik fuer Diagnostische und Interventionelle Radiologie, Ulm (Germany)

    2015-07-15

    wichtige Saeule zur Festlegung der Behandlung. Die besondere Bedeutung des Strahlenschutzes bei Kindern bedingt eine veraenderte Methodenwahl im Vergleich zu Erwachsenen. So haben Sonographie und MRT als ergaenzende und/oder weiterfuehrende Untersuchungsmethoden einen hoeheren Stellenwert als die Computertomographie im Erwachsenenalter. Haeufigste Fragestellung ist der Verdacht/Ausschluss einer Pneumonie. Dazu ist eine Thoraxaufnahme im a.-p.- oder p.-a.-Strahlengang ausreichend, teils flankiert von der Thoraxsonographie, um bei Beschwerdepersistenz letztere als Verlaufsbildgebung einzusetzen. Die Sonographie wird zudem zur Abklaerung auffaelliger Strukturen im Thoraxraum (Thymus, Sequester) eingesetzt und kann zur definitiven Klaerung fuehren. Der Roentgenthorax ist zudem ideal zur Abklaerung typischer Anpassungsstoerungen nach Geburt wie der transitorischen Tachypnoe (''wet lung disease'') oder dem Surfactantmangel. Durchleuchtungsuntersuchungen werden zur Abklaerung bei Aspirations- und/oder Ingestionsverdacht im Kleinkindalter eingesetzt. Die Computertomographie hat Bedeutung im Staging bzw. in der Nachsorge von Tumorerkrankungen. Technische Neuerungen (z. B. iterative Rekonstruktion) haben zu einer signifikanten Minderung der Strahlenexposition der CT gefuehrt. Die MRT wird derzeit nur vereinzelt zur Abklaerung bei Anlagestoerungen (Sequester) oder Tumorerkrankungen eingesetzt, ihr Potenzial zur Darstellung funktioneller Aspekte (Perfusion und Ventilation) laesst aber einen breiteren Einsatz in Zukunft erwarten. (orig.)

  10. Experimental data for insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) in prevention of radiation myelopathy; Experimentelle Daten zum Einsatz von Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) zur Praevention einer Strahlenmyelopathie

    Energy Technology Data Exchange (ETDEWEB)

    Nieder, C. [Technische Univ. Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Price, R.E.; Rivera, B. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Veterinary Medicine and Surgery; Andratschke, N.; Kian Ang, K. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Experimental Radiation Oncology

    2002-03-01

    Background: Current models of radiation myelopathy provide a rationale for growth factor-based prevention strategies. Thus, we tested whether insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) alone or in combination modulate radiation tolerance of the rat cervical spinal cord. Materials and Methods: The cervical spinal cord of 68 adult Fisher F344 rats received a total dose of 30-36 Gy, given as a single fraction of 16 Gy followed by a second radiation dose of 14-20 Gy. Continuous intrathecal infusion of bFGF (44 rats) or saline (24 rats) into the cisterna magna was given concomitantly. A further experiment included 14 additional rats which were treated with subcutaneous injection of IGF-1 parallel to irradiation with a total dose of 34 Gy or 36 Gy. 20 rats received combined treatment, i.e. intrathecal infusion of bFGF plus subcutaneous injection of IGF-1, starting 24 hours before irradiation (total dose 33 Gy or 36 Gy) for a total of 4 days. Animals were followed until myelopathy developed or for a maximum of 12 months. Histopathologic examinations were performed post mortem. Results: Treatment with bFGF alone or IGF-1 alone increased the median time to myelopathy significantly. In the 36-Gy group, after combination treatment a comparable prolongation of latency was seen. Moreover, rats treated with 33 Gy and combined bFGF plus IGF-1 showed a significantly reduced risk of myelopathy, too (p = 0.0015). (orig.) [German] Hintergrund: Aktuelle Modelle zur Pathogenese der Strahlenmyelopathie lassen den praeventiven Einsatz von Wachstumsfaktoren sinnvoll erscheinen. Daher sollte ueberprueft werden, ob Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) als Einzelsubstanzen oder in Kombination die Strahlentoleranz des zervikalen Rueckenmarks von Ratten beeinflussen. Material und Methoden: Das Zervikalmark von 68 erwachsenen Fisher-F344-Ratten wurde mit zwei Einzelfraktionen bis insgesamt 30-36 Gy bestrahlt (16 Gy

  11. Editorial

    Directory of Open Access Journals (Sweden)

    Gabrielle Stoll

    2010-12-01

    Das PSZ kann auf eine beständige Lehrtradition zur psychoanalytischen Arbeit mit Kindern und Jugendlichen zurückblicken, die bis in die Siebzigerjahre zurückreicht. Zwar führte die Kinderanlayse zur Gründungszeit des Seminars noch eine eher randständige Existenz und wurde lediglich von einigen wenigen, wie Jacques Berna oder Pedro Grosz, vertreten. Berna sollte später nach Hamburg auswandern und dort den holländischen Kinder- und Jugendpsychiater Sjef Teuns kennenlernen. Um diesen und Bianca Gordon, einer Londoner Kinderanalytikerin, die ihrerseits auf Veranlassung von Sjef Teuns nach Zürich eingeladen worden war, entwickelte sich im Laufe der Jahre eine stetig wachsende Gruppe von AnalytikerInnen, welche die psychoanalytische Kinder- und Jugendlichenpsychotherapie kontinuierlich förderten und lehrten. Heute ist die aus diesen Entwicklungen hervorgegangene «Ressortgruppe Kinder- und Jugendlichenpsychotherapie am PSZ» in der Lage, eine schweizweit einzigartige Weiterbildung in dieser Arbeit anzubieten (siehe: www.psychoanalyse-zuerich.ch. Drei der fünf Autoren sind aktuell Mitglieder der Ressortgruppe: Daniel Bischof, Egon Garstick und Jürgen Grieser. Sie gestalten daher das Kursangebot der laufenden Weiterbildung wesentlich mit. Im vorliegenden Heft ergreifen sie die Gelegenheit, die gegenwärtige Arbeit von Psychoanalytikerinnen und Psychoanalytikern des PSZ mit Kindern und Jugendlichen im Praxisalltag vorzustellen sowie einen Einblick in deren theoretische Reflexion zu vermitteln. Es ist der Autoren Ziel darlegen zu können, wie unter verschiedenen theoretischen Aspekten, die alle dem psychoanalytischen Verständnis zuzuordnen sind, in der Praxis gearbeitet wird. Dabei liegt ihnen daran zu verdeutlichen, dass die Umsetzung des analytischen Denkens in der Arbeit mit Kindern und Jugendlichen in äußerst vielfältiger Form stattfindet und den für KinderanalytikerInnen so vertrauten Gedanken zu veranschaulichen, dass Psychoanalyse im Kern als

  12. Auch Führen will gelernt sein: Angebot und Nachfrage nach Weiterbildung in Betriebswirtschaftslehre für Krankenhausärzte [Leading does not come naturally: supply and demand for further training in hospital aministration for medical professionals

    National Research Council Canada - National Science Library

    Lueke, Sven; Fleßa, Steffen

    2009-01-01

    [english] The leadership of departments and hospitals requires qualifications in the fields of personnel and financial management, marketing and strategy, but only few medical experts in leadership positions...

  13. Practical experience with gas permeability tests by the new SoMIT method in Etzel cavern field; Praktische Erfahrungen mit Gasdichtheitstests nach dem neuen SoMIT-Verfahren im Kavernenfeld Etzel

    Energy Technology Data Exchange (ETDEWEB)

    Boor, S.; Huebner, S. [KBB Underground Technologies GmbH, Hannover (Germany); Schweinsberg, H.J. [IVG Logistik GmbH, Bonn (Germany); Tryller, H. von [SOCON, Giessen (Germany)

    2007-09-13

    In the course of restructuring and extension measures in the Etzel cavern field, IVG Logistik GmbH has been retrofitting oil storage caverns into gas storage caverns since November 2005. Before completion can be started, gastightness of all wells had to be checked. This was done, for the first time, using the SoMIT (Sonar Mechanical Integrity Testing) process in which the level is gauged continuously by an ultrasonic probe. This method is more accurate by about a power of ten than the conventional gamma-gamma probe. Further, continuous measurement enables in-time evaluation of trends. As IVG had good results with the conventional test method in Etzel cavern field, the higher accuracy of the SoMIT method was used for shortening the test time and achieving a cost reduction. SoMIT also has operative advantages. For example, there are no repeated measurements which would require resetting of the probe to the reference depth and might also cause measuring errors. Further, the measurements are not influenced by oil residues in the cavern as the ultrasonic probe is used above the fluid level. (orig.)

  14. Breathhold MRI of the small bowel in Crohn`s disease after enteroklysis with oral magnetic particles; Duenndarm-MRT mit schnellen MR-Sequenzen bei Morbus Crohn nach Enteroklysma mit oralen Eisenpartikeln

    Energy Technology Data Exchange (ETDEWEB)

    Holzknecht, N.; Helmberger, T.; Gauger, J.; Faber, S.; Reiser, M. [Inst. fuer Radiologische Diagnostik, Klinikum Grosshadern, Ludwig-Maximilians-Univ. Muenchen (Germany); Ritter, C. von [Medizinische Klinik 2, Klinikum Grosshadern, Ludwig-Maximilians-Univ. Muenchen (Germany)

    1998-01-01

    Purpose: To evaluate the efficacy of breathhold MRI following enteroclysis with addition of oral magnetic particles to study the extension, detection of stenoses and extraluminal manifestations in Crohn`s disease. Results: Typical findings were marked bowel wall thickening with strong contrast enhancement. 95.8% of affected small bowel segments and 94.7% of stenoses were correctly detected by MRI. All four fistulas were detected and important extraluminal findings were seen in 6/18 patients. Additionally, one ileoileal and two ileosigmoidal adhesions, two extraluminal abscesses and affection of the right ureter were delineated. Conclusion: MRI in Crohn`s disease offers the potential to avoid radiation exposure in this relatively young patient group. Important additional findings relevant to indication of surgery are seen in approximately one third of cases. The replacement of transduodenal intubation by oral contrast application remains to be further studied. (orig./AJ) [Deutsch] Das Ziel dieser Arbeit war der Vergleich der diagnostischen Effizienz des konventionellen Duenndarmenteroklysmas mit anschliessender MRT mit negativem oralem Kontrastmittel bezueglich der Ausdehnung, Stenoseerkennung und relevanter Zusatzinformation bei Morbus Crohn. Im Vergleich mit dem Enteroklysma konnte die MRT-Untersuchung 95,8% der befallenden Segmente und 94,7% der Stenosen identifizieren. Alle 4 Fisteln wurden detektiert und zusaetzlich relevante Befunde in 6 von 18 Patienten gesehen (eine ileoileale und 2 ileosigmoidale Adhaesionen, 2 extraluminale Abzesse und ein entzuendlicher Pseudotumor mit Einbeziehung des rechten Ureters). Das Stenosegrading zeigte keine signifikanten Unterschiede (p=0,11). Zusaetzlich wurden extraluminal eine mesenteriale Lymphadenopathie (15/18) und mesenteriale Fettgewebsproliferation (12/18) mittels MRT nachgewiesen. (orig./AJ)

  15. Contribution to the U$_2$C$_3$ formation by the synthetic reaction and by the decomposition of UC$_2$; Beitrag zur U$_2$C$_3$-bildung nach der synthetischen reaktion und durch zerfall von UC$_2$

    Energy Technology Data Exchange (ETDEWEB)

    Buschinelli, A.J.A.

    1974-06-01

    This work is a contribution to the study of the mechanism and of the kinetics of the U$_2$C$_3$ formation by the synthetic reaction. The influences of a mechanical and a thermical pre-treatment of the samples on the reaction kinetics were investigated and discussed taking into account other information from the literature. The relative increasing of the U$_2$C$_3$ nucleation rate due to the pulverization corresponds approximately to the surface enlargement of the pulverized material. The activation energy for the synthetic reaction in powder was found to be 94 +- 7 kcal/mol. The negative influence of nitrogen, oxygen and tungsten on the U$_2$C$_3$ formation was reported. In the decomposition of UC$_2$ to U$_2$C$_3$ and graphite, the influences of the morphology of the graphite precipitate and the fast neutron irradiation on the beginning of the U$_2$C$_3$ formation were also investigated.

  16. Utilisation of residues in coal and ore mining in Nordrhein-Westfalen according to the specifications of mining law. Verwertung von Reststoffen im Steinkohle- und Erzbergbau Nordrhein-Westfalens im Betriebsplanverfahren nach Bundesbergrecht

    Energy Technology Data Exchange (ETDEWEB)

    Czech, H. (Landesoberbergamt Nordrhein-Westfalen, Dortmund (Germany))

    1992-12-01

    In order to stabilize the marketing position of domestic coal and lignite, the mining industry of North-Rhine-Westphalia developed a new sales strategy about 10 years ago. Apart from supplying coal to their customers, Rheinbraun AG and Ruhrkohle AG also took care of the disposal of residues from power plants, heating stations, and furnaces. This induced many communal and private plant owners to continue buying domestic coal - especially in southern Germany where disposal of residues was impossible or too costly. The brown coal residues were dumped in the Rheinish brown coal district, which had ample capacity. In the case of hard coal residues, the industry had to develop and test techniques for underground dumping. (orig./HS).

  17. Monte Carlo simulations to calculate energy doses in a cow after continuous ingestion of CS 137 and K 40; Monte-Carlo-Simulationen zur Berechnung der Energiedosis in einem Rind nach kontinuierlicher Aufnahme von CS 137 und K 40

    Energy Technology Data Exchange (ETDEWEB)

    Pichl, E. [Technische Univ. Graz (Austria). Inst. fuer Medizintechnik; Rabitsch, H. [Technische Univ. Graz (Austria). Arbeitsgebiet Strahlenphysik

    2009-07-01

    Currently ICRP (International Commission on Radiological Protection) develops a new recommendation to estimate the natural radiation exposure of an agreed set of animals and reference plants. For estimating effective dose in humans and animals, the incorporated activities of natural and artificial radionuclides in body tissues and contents of the digestive system have to be known. It was the aim of this investigation to calculate energy doses caused by Cs 137 and K 40 in the reproductive organs (uterus, ovaries) of a cow. During its whole lifetime from 1986 to 1992, the cow incorporated continuously Cs 137 which was due to the fallout following the Chernobyl accident. K 40 occurs naturally in the cow's fodder. The cow was born in a highly contaminated region of Styria, Austria, and was infertile since 1990. The activities of Cs 137 and K 40 in the cow's fodder and in tissues, organs and contents of the digestive system of the carcass were measured simultaneously with the help of semiconductor detectors. To calculate the specific absorbed fractions by means of the Monte Carlo code MCNP, an appropriate simulation model for the reproductive organs and their surrounding tissues was developed. The contents of rectum and urinary bladder account for the main part of the energy dose in the reproductive organs. Comparison of our results with data from other investigations showed, that lifetime accumulation of Cs 137 and K 40 was too low to cause radiation inferred infertility. (orig.)

  18. Radioiodine therapy for combined disseminated and nodular thyroid autonomy. Results after using a correction term for the disseminated part; Radioiodtherapie bei kombinierter Schilddruesenautonomie. Ergebnisse nach Korrektur fuer disseminierte Anteile

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H.; Dorn, R.; Otto, I.; Sciuk, J. [Klinik fuer Nuklearmedizin, Klinikum Augsburg (Germany); Wengenmair, H.; Kopp, J. [Medizinische Physik und Strahlenschutz, Klinikum Augsburg (Germany)

    2006-07-01

    Aim: in combined focal and disseminated thyroid autonomy a variety of concepts in the treatment with radioiodine are used. The difference lies mainly in the calculation of the autonomous volume. This retrospective study shows a new method of calculating the autonomous volume. Patients and methods: in 398 patients with combined thyroid autonomy and good correlation of scintigraphically hot nodules and lesions defined by ultrasound the volume of the nodules is ascertained from scintigraphic and ultrasound parameters and the volume of the disseminated autonomous tissue is assessed with a weighting factor (VF). This factor is the ratio of impulse density in a ROI over the disseminated volume divided by the corresponding impulse density over the nodular volume of the thyroid scintigraphy. The sum of nodular volume and weighted perinodular volume gives the total autonomous volume. A standard radioiodine test gives the maximum iodine-131-uptake and effective half-life to calculate the activity to obtain a treatment dose of 400 Gy. Results: the rate of success with and without thyrostatic medication was 97% with an 18.6% rate of hypothyroidism observed from 4 months post therapy onwards. Conclusion: the use of the weighting factor VF in the treatment of combined autonomy leads to an excellent rate of success in patients with good correlation of functional imaging and ultrasound findings. (orig.)

  19. Pooling of ground-mounted photovoltaic plants under Art. 19 Section 1a of the 2012 German Renewable Energy Law; Die Zusammenfassung von Photovoltaik-Freiflaechenanlagen nach paragraph 19 Abs. 1a EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Assion, Anja; Goetze, Roman [GOeTZE Rechtsanwaelte, Leipzig (Germany)

    2013-11-01

    Under the 2012 PV amendment to the German Renewable Energy Law (EEG) compensation payments for electricity generated from solar radiation energy harvested on ground-mounted photovoltaic plants are now restricted to plants up to an installed capacity of 10 MW. For photovoltaic plants of greater capacity the right to compensation no longer applies to that in excess of 10 MW. The intent of the legislature in limiting the right to compensation according to a plant's capacity is to moderate the rate of newly installed capacity, promote local production close to the point of use, and to preserve landscapes and guard against land consumption. The new regulation is a novelty in as far it applies to ground-mounted plants. It combines a cap on the electricity generating capacity for which operators are entitled to compensation with a regulation on the pooling of plants (fictitious single plant) for purposes of compensation calculation. This regulation has given rise to many controversial issues in practice. This is due in part to the absence of case law and the failure, to date, to draw up special conventions, for example on the part of the EEG Clearing Office. At present there is virtually no aspect of the situation over which the grid operators are in agreement. The purpose of this article is to present the current state of the discussion, assess the positions brought forward so far and use this as a basis for developing a new view on the interpretation of Art. 19 Section 1a of the EEG.

  20. 1:0 for Spain. After the soccer World Championship, Spain won an important solar contest in South Africa; 1:0 fuer Spanien. Nach der Fussball-WM hat Spanien in Suedafrika nun einen wichtigen Solarwettbewerb gewonnen

    Energy Technology Data Exchange (ETDEWEB)

    Rosell, Alejandro Diego; Mattke, Sascha

    2012-03-15

    Spanish manufacturers acquired more orders for construction of industrial-scale PV systems in South Africa than their competitors from other countries. German manufacturers managed to get contracts as partners in several projects.

  1. Search for new ways of production of diesel fuels from fats and oils on the basis of renewable raw materials; Suche nach neuen Wegen zur Gewinnung von Dieselkraftstoffen aus Fetten und Oelen auf der Basis von nachwachsenden Rohstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Paetzold, Eckhard [Leibniz-Institut fuer Katalyse an der Universitaet Rostock e.V., Rostock (Germany); Schuemann, Ulrike [Rostock Univ. (Germany). Lehrstuhl fuer Kolbenmaschinen und Verbrennungsmotoren; Kragl, Udo [Leibniz-Institut fuer Katalyse an der Universitaet Rostock e.V., Rostock (Germany); Rostock Univ. (Germany). Inst. fuer Chemie

    2012-07-01

    Fats and oils are one of the oldest classes of chemical compounds used by humans. Natural fats consist of a hydrocarbon chain with double bonds and carboxylic/ester functions. They can be converted by hydrogenation and decarboxylation using heterogeneous catalysts at high temperature (450 C) and high hydrogen pressure (150 bar). Conversion of fats and oils by hydrogenation and decarboxylation with homogeneous noble metal catalysts at essential milder conditions for different applications as hydrotreated vegetable oil is possible as well. The reactions were studied by model compounds for the hydrogenation of double bonds e.g. linolenic acid and the decarboxylation of stearic acid. It was found that palladium nanoparticles can be used as catalyst in a two phase reaction. (orig.)

  2. Review: Claudia Rademacher & Peter Wiechens (Eds.) (2000). Verstehen und Kritik. Soziologische Suchbewegungen nach dem Ende der Gewissheiten. Festschrift für Rolf Eickelpasch [Understanding and Critique. Sociological Enquiries After the End of Certainties. Festschrift for Rolf Eickelpasch

    OpenAIRE

    Daniel Osterwalder

    2004-01-01

    In "Verstehen und Kritik" various authors attempt to find different opportunities and ways to analyze and describe the complexity of the world at large. The parting from the general views (e.g. of MARX or WEBER) leads to a juxtaposition of different theoretical perspectives. The contributions published in "Verstehen und Kritik" examine several methods and theories that reveal the differences and the possible commonalties e.g. between the work of the "Frankfurter Institut für Sozialforschung" ...

  3. Study on microstructures of electron beam and gas tungsten arc Ti-6Al-4V weld metals; Gefuegeuntersuchungen nach Elektronenstrahlschweissen und Wolfram-Schutzgasschweissen von Ti-6Al-4V

    Energy Technology Data Exchange (ETDEWEB)

    Radhakrisha, C. [Indian Inst. of Technology, Madras (India). Dept. of Metallurgical Engineering; Raghurami Reddy, J. [Indian Inst. of Technology, Madras (India). Dept. of Metallurgical Engineering; Prasad Rao, K. [Indian Inst. of Technology, Madras (India). Dept. of Metallurgical Engineering

    1997-04-01

    EB as-welded metals exhibited predominantly {alpha}` martensitic structure containing extensive dislocation network, while GTA as-welded metals showed diffusional {alpha} along with {alpha}`. Increase in EB weld heat input increased the {alpha}` platelet width. The two passes B-O-B EB weld metals showed wider {alpha}` platelets compared to their single pass counterparts. Water quenching from 930 C (1 h) resulted in predominantly {alpha}` structure and acicular {alpha}. Acicular {alpha} plates found in 930 C/1 h/AC GTA weld metals were found to be relatively coarser than their EB weld metal counterparts. Furnace cooling from 930 C further increased {alpha} plate width. Prolonged exposure at 930 C for 3 h followed by air or furnace cooling caused relatively thicker grain boundary {alpha}. The tendency was for the globularisation of {alpha}. The weld metals exposed to 930 C/1 h/FC resulted in the form of coarser {alpha} platelets. Dislocation density decreased and {beta} was found to precipitate between {alpha} platelets. Taking to 1020 C and quenching resulted in {alpha}` martensitic structure irrespective of prior microstructural and heat input differences. Basketweave type structure which was noticed for the base metal was noted for the weld metals aircooled from 1020 C. While water quenched samples from 930 C showed predominantly {alpha}` martensitic structure, their quenched and aged counterparts exhibited grain boundary and intergranular {alpha}. In-situ PWHT weld metals showed fine and extensive precipitation of {beta} at the walls of {alpha} platelets and the dislocations within the platelets. (orig.) [Deutsch] EB-Schweissverbindungen zeigten vorwiegend ein martensitisches {alpha}`-Gefuege mit einem ausgedehnten Versetzungsnetzwerk, waehrend GTA-Schweissverbindungen diffusives {alpha} zusammen mit {alpha}` enthielten. Eine Erhoehung der Waermeeinbringung bei EB-Schweissgut erhoehte die Breite der {alpha}`-Plaettchen. Zweilagig ueberlappende B-o-B-Schweissverbindungen zeigten breitere {alpha}`-Plaettchen im Vergleich zu den Vergleichsproben mit einlagigen Zugraupen. Wasserabschrecken von 930 C (1 h) ergab hauptsaechlich eine {alpha}`-Struktur und nadelfoermiges {alpha}. Die in bei 930 C/1 h/AC behandelten GTA-Schweissverbindungen auftretenden nadelfoermigen {alpha}-Platten waren relativ groeber als die in den EB-Schweissverbindungen. Ofenabkuehlung von 930 C erhoehte die {alpha}-Plattendicke weiter. Eine verlaengerte Haltezeit bei 930 C fuer 3 h mit nachfolgender Abkuehlung an Luft oder im Ofen bewirkte relativ dickeres Korngrenzen-{alpha}. Es zeigte sich eine Tendenz zur Kugelbildung bei {alpha}. Das bei 930 C/1 h/FC gehaltene Schweissgut ergab groebere {alpha}-Plaettchen. Die Versetzungsdichte nahm ab, und {beta} schied sich zwischen den {alpha}-Plaettchen aus. Bei einer Haltetemperatur von 1020 C und nachfolgender Abschreckung bildete sich ein martensitisches {alpha}`-Gefuege unabhaengig von frueheren Unterschieden in Gefuege und Waermeeinbringung. Eine im Grundwerkstoff beobachtete flechtwerkartige Struktur wurde auch in den von 1020 C an Luft abgekuehlten Schweissguetern gefunden. Waehrend in Wasser von 930 C abgeschreckte Proben eine vorwiegend martensitische {alpha}`-Struktur zeigten, konnte bei den abgeschreckten und ausgelagerten Vergleichsproben Korngrenzen-{alpha} und intergranulares {alpha} festgestellt werden. (orig.)

  4. Search for solar axions with the X-ray telescope of the CAST experiment (phase II); Suche nach solaren Axionen mit dem Roentgenteleskop des CAST-Experiments (Phase II)

    Energy Technology Data Exchange (ETDEWEB)

    Nordt, Annika

    2009-10-14

    The CAST (CERN Solar Axion Telescope) experiment is searching for solar axions by their conversion into photons inside a transverse magnetic field. So far, no solar axionsignal has been detected, but a new upper limit could be given (CAST Phase I). Since 2005, CAST entered in its second phase where it operates with a buffer gas ({sup 4}He) in the conversion region to extend the sensitivity of the experiment to higher axionmasses. For the first time it is possible to enter the theoretically favored axion massrange and to give an upper limit for this solar axion mass-range (>0.02 eV). This thesis is about the analysis of the X-ray telescope data Phase II with {sup 4}He inside the magnet. The result for the coupling constant of axions to photons is: g{sub {alpha}}{sub {gamma}}{sub {gamma}}<1.6-6.0 x 10{sup -10} GeV{sup -1} (95%C.L.) for m{sub a}=0.02-0.4 eV. (2) This result is better than any result that has been given before in this mass range for solar axions. (orig.)

  5. Role of Hypoxia-inducible factor-1 and its target genes in human lung adenocarcinoma cells after photon- versus carbon ion irradiation; Expression HIF-1-abhaengiger Gene in humanen Lungenadenokarzinom (A549)-Zellen und deren Regulation nach Photonen- und Schwerionenbestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Bill, Verena Maria

    2013-11-26

    Exposed to hypoxia tumor cells are notably resistant to photon irradiation. The hypoxiainducible transcription factor 1α (HIF-1α) seems to play a fundamental role in this resistance, while its role after heavy-ion beam remains unknown. The intention of this study was to determine how A549-cells (non-small-cell lung carcinoma) react in different oxygenation states after irradiation with photons or heavy ions, particularly in regards to their expression of HIF-1 target genes. Resistance of hypoxic A549 cells after photon irradiation was documented by cellular and clonogenic survival. In contrast, cellular survival after heavy-ion irradiation in hypoxic cells was not elevated to normoxic cells. Among the oxygen dependent regulation of HIF-1 target genes, gene expression analyses showed an increased expression of GLUT-1, LDH-A, PDK-1 and VEGF after photon irradiation but not after heavy-ion irradiation after 48 hours in normoxic cells. As expected, CDKN1A as inhibitor of cell cycle progression showed higher expression after both radiation forms; interestingly CDKN1A was also in an oxygen dependent manner lightly upregulated. In western blot analyses we demonstrated a significant increase of HIF-1 and GLUT-1 caused by hypoxia, but only a tendency of increased protein level in hypoxia after photon irradiation and no changes after heavy-ion irradiation. Significantly higher protein level of secreted VEGF-A could be measured 72 hours after photon irradiation in normoxic cells by ELISA analyses. Controversially discussed, I could not detect an association between HIF-1 and SCF or Trx-1 in A549-cells in this study. Whereas Trx-1-expression was neither influenced by changed oxygen partial pressure nor irradiation, I could show increased SCF mRNA by quantitative Real Time-PCR and secreted protein level by ELISA after photon irradiation independent of oxygen state. In summary, this study showed that HIF-1 and its target genes (GLUT-1, LDHA; PDK, VEGF) and also SCF was increased after photon irradiation and therefore could take part in radioresistance of photon irradiation therapy in contrast to heavy ions. These results suggest a further benefit of the radiotherapy using heavy ions for non-small cell lung cancer.

  6. Comparison of relevant parameters of multi-pixel sensors for tracker detectors after irradiation with high proton and neutron fluences; Vergleich relevanter Parameter von Multipixelsensoren fuer Spurdetektoren nach Bestrahlung mit hohen Proton- und Neutronfluessen

    Energy Technology Data Exchange (ETDEWEB)

    Bergholz, Matthias

    2016-03-15

    The further increase of the luminosity of the Large Hadron Collider (LHC) at CERN requires new sensors for the tracking detector of the Compact Muon Soleniod (CMS) experiment. These sensors must be more radiation hard and of a finer granularity to lower the occupancy. In addition the new sensor modules must have a lower material budget and have to be self triggering. Sensor prototypes, the so called ''MPix''-sensors, produced on different materials were investigated for their radiation hardness. These sensors were fully characterized before and after irradiation. Of particular interest was the comparison of different bias methods, different materials and the influence of various geometries. The degeneration rate differs for the different sensor materials. The increase of the dark current of Float-Zone-Silicon is stronger for thicker sensors and less than for Magnetic-Czochralski-Silicon sensors. Both tested bias structures are damaged by the irradiation. The poly silicon resistance increases after irradiation by fifty percent. The Punch-Through-Structure is more effected by irradiation. The punch-through voltage increase by a factor of two. Due to the higher pixel current, the working point of the sensor is shifted to smaller differential resistances.

  7. What is the right way to run a transport route infrastructure?; Wie betreibt man Verkehrswegeinfrastruktur richtig? Behoerde oder Gesellschaft nach Handelsrecht: Welche Organisation garantiert in Zeiten knapper Kassen der oeffentlichen Hand hoehere Effizienz bei gleicher Qualitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Scherz, Wolfgang [Hessische Landesbahn GmbH (HLB), Kassel (Germany). Infrastruktur-Agentur Hessen; Averkamp, Michael

    2010-07-01

    From the perspective of owners of publicly accessible transport route infrastructure - especially at a time when budgets are tight - there are two major questions that need to be posed and a rapid answer demanded: does a maintenance organisation established in the form of a public agency or a commercial enterprise yield better results, that is, higher and better output with declining input (agency versus company); and should an agency or transport infrastructure firm outsource all or part of its maintenance organisation (make-or-buy)? The authors, based on their experience gained in a variety of management functions in corporations and agencies as well as in executive coaching, provide quite different perspectives on these issues. (orig.)

  8. The large questions after Chernobyl. What are Becquerels and what are the hazards?; Die grosse Frage nach Tschernobyl. Was sind und wie misst man Bequerels, und wie gefaehrlich sind sie?

    Energy Technology Data Exchange (ETDEWEB)

    Maushart, Rupprecht

    2016-05-01

    In consequence of Chernobyl private persons and public officers wanted or had to measure radioactivity without any knowledge on the issue. Experiences form this situation are summarized and discussed with respect to the production of appropriate measuring instruments and reasonable descriptions.

  9. Owners responsibility of refrigeration equipment according F-Gas-regulation 'EC 842/2006' and answers; Betreiberpflichten nach 'F-Gas-Verordnung' EG 842/2006 und Antworten darauf

    Energy Technology Data Exchange (ETDEWEB)

    Beermann, Karsten [IKKE gGmbH, Duisburg (Germany)

    2012-08-15

    The results of the F-Gas-regulation EC 842/2006 are some responsibilities for owners of refrigeration equipment. To fulfill these duties exist e-learning training modules and different tools which are the result of a European LEONARDO- project. Particularly the awareness of the equipment owner and the certified person (refrigeration technician) according the regulation will be the main background of a safe handling of refrigerants for an effective environmental protection. Interested persons and companies will find helpful information to learn good practice. (orig.)

  10. Disposal of residues according paragraph 97 StrlSchV - Efficient self control and handling of applications for release from regulatory control; Entsorgung von Rueckstaenden nach paragraph 97 StrlSchV - effektive Selbstueberwachung und Bearbeitung von Entlassungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Gellermann, R. [HGN Hydrogeologie GmbH, Braunschweig (Germany)

    2005-07-01

    To control residues according to paragraph 97 of the German Radiation Protection Ordinance (StrlSchV), the ordinance earmarks a self - control of involved companies in the case of very low specific activities, an authorisation of release from regulatory control to disposal in the case of higher specific activities and a balancing of disposed activities in the case of large amounts. The realisation of this regulation requires the exchange of information between owners of residues, disposing companies and authorities. In order to make this information available and controllable in an efficient way, a well structured system of documents was developed analogue to an existing system in waste management. Practical experiences with this system are discussed. (orig.)

  11. Auch Führen will gelernt sein: Angebot und Nachfrage nach Weiterbildung in Betriebswirtschaftslehre für Krankenhausärzte [Leading does not come naturally: supply and demand for further training in hospital aministration for medical professionals

    Directory of Open Access Journals (Sweden)

    Lueke, Sven

    2009-08-01

    Full Text Available [english] The leadership of departments and hospitals requires qualifications in the fields of personnel and financial management, marketing and strategy, but only few medical experts in leadership positions have been trained in these subjects. This is especially the case in leadership as a part of the management process. This paper discusses the results of two studies analyzing the supply and demand with respect to training in the fields of hospital administration and management for medical experts in hospitals, with a particular emphasis on leadership training. It is shown that these professionals are aware of the fact that they need further training in these and other fields, but their willingness to pay for it is quite limited. At the same time, there is a broad supply of general courses, but hardly any programs specially designed for medical professionals in leadership positions in hospitals. [german] Die Führung von Fachabteilungen und von ganzen Krankenhäusern erfordert Kompetenzen in den Bereichen Personalführung, Finanzmanagement, Marketing und Strategie, aber die wenigsten Chef- und Oberärzte haben während ihrer medizinischen Ausbildung eine entsprechende Qualifizierung erfahren. Dies ist insbesondere der Fall bei Führung als Teil des Managementprozesses. Der vorliegende Artikel stellt Ergebnisse zweier Studien vor, in der die Nachfrage und das Angebot an Weiterbildung in den Bereichen Betriebswirtschaft und Management für im Krankenhaus tätige Mediziner analysiert werden mit schwerpunktmäßiger Betrachtung der Führungskompetenzen. Es zeigt sich ein hohes Bewusstsein der Chef- und Oberärzte für die Notwendigkeit an Weiterbildung in diesem und anderen Bereichen und eine hohe Bereitschaft, hierfür Zeit zu investieren. Gleichzeitig besteht jedoch eine geringe Zahlungsbereitschaft. Gleichzeitig bestehen aber auch zahlreiche Angebote für eine allgemeine Fortbildung in diesem Bereich, jedoch kaum maßgeschneiderte Programme für Chef- und Oberärzte.

  12. Elke Frietsch, Christina Herkommer (Hg.: Nationalsozialismus und Geschlecht. Zur Politisierung und Ästhetisierung von Körper, „Rasse“ und Sexualität im „Dritten Reich“ und nach 1945. Bielefeld: transcript Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Veronika Springmann

    2009-11-01

    Full Text Available The conference volume at hand collects 21 essays that deal with conceptions, constructions, conceptions, and projections of gender from very different perspectives that each examine National Socialism. Although the expansiveness of the volume is at first daunting, an examination of a few articles is worthwhile.Der vorliegende Tagungsband versammelt 21 Aufsätze, die sich aus sehr unterschiedlichen Perspektiven mit Vorstellungen, Konstruktionen, Konzeptionen und Projektionen von Geschlecht jeweils in Auseinandersetzung mit dem Nationalsozialismus beschäftigen. Auch wenn die Fülle des Bandes zunächst erschlägt, lohnt sich die Auseinandersetzung mit einigen Aufsätzen.

  13. Rezension zu: Elke Frietsch, Christina Herkommer (Hg.: Nationalsozialismus und Geschlecht. Zur Politisierung und Ästhetisierung von Körper, „Rasse“ und Sexualität im „Dritten Reich“ und nach 1945. Bielefeld: transcript Verlag 2009.

    Directory of Open Access Journals (Sweden)

    Veronika Springmann

    2009-10-01

    Full Text Available The conference volume at hand collects 21 essays that deal with conceptions, constructions, conceptions, and projections of gender from very different perspectives that each examine National Socialism. Although the expansiveness of the volume is at first daunting, an examination of a few articles is worthwhile.

  14. Reliability of biomass plants. Conditions for permission according to building planning law and environmental law under special consideration of the legal situation; Zulaessigkeit von Biomasseanlagen. Genehmigungsvoraussetzungen nach Bauplanungs- und Umweltrecht sowie Verfahrensfragen unter besonderer Beruecksichtigung der Rechtslage im Land Brandenburg

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-11-15

    The climate change accelerated the discussion on renewable energies and sharpened the public consciousness for it. This particularly is correct in the case of the use of biomass. However, the power generation and heat generation by transformation of biomass is in a licensing area of conflict between the regulations of the building law, the regulations of the immission prevention, the nature protection and the ground-water protection. Under this aspect, the contribution under consideration reports on the mutual relations between building planning law and immission prevention law according to both material considerations and procedural considerations.

  15. Investigations into the influence of therapeutic measures on the repair of spontaneous mechanisms of defence following radiation injury. Untersuchungen ueber Moeglichkeiten, die Wiederherstellung der koerpereigenen Abwehr nach Strahlenschaedigung durch therapeutische Massnahmen zu beeinflussen

    Energy Technology Data Exchange (ETDEWEB)

    Nothdurft, W.; Fliedner, T.M.; Baltschukat, K.; Kreja, L.; Selig, C.

    1992-01-01

    Investigations into the influence of therapeutic measures on the repair of spontaneous mechanisms of defence following radiation injury. The aim of this project was to develop procedures for the repair of the body's own mechanisms of defence following radiation injury and to test these on the basis of animal models. After consultation of the relevant literature and in vivo experiments as a preliminary to the in vivo studies in dogs, recombinant human colony-stimulating factor rhGM-CSF was chosen from among a series of different cytokinins. The influence of rhGM-CSF on granulocytopoiesis and monocytophoiesis was at first studied in an animal having undisturbed bone marrow function. Treatment with daily doses of 30 [mu]g/kg on five consecutive days led to a markedly pronounced increase of granulocytopoiesis and an only modest increase of the monocyte concentration of the blood. For the studies in irradiated dogs, treatment was carried out over a period of 21 days. Each of 2 dogs received daily doses of 10 [mu]g/kg or 30 [mu]g/kg administered by subcutaneous injection. These were in each case divided into two equal fractions being given in the morning and at night. The results lead to the conclusion that the treatment of irradiated individuals with rhGM-CSF alone (monotherapy) may be expected to have favourable effects in respect of granulocytopoiesis and monocytopoiesis. This appears, however, to hold only for cases where the radiation damage to the bone marrow is not much more pronounced than that from homogeneous wholebody irradiation using doses in the range between 3 and 3.5 Gy. It is still open to discussion, if and to which extent such treatments with rhGM-CSF are associated with untoward effects on certain hematological parameters. (orig./MG).

  16. Modellvorhaben „Verpflegung in Kindertagesstätten mit Bioprodukten“ (Nachhaltige Steigerung des Einsatzes von nach der EU-Verordnung 2092/91 zertifizierten Ökoprodukten in der Außer-Haus-Verpflegung von Kindern und Jugendlichen)

    OpenAIRE

    Buley, Marion; Piecha, Torsten

    2006-01-01

    Ziel: Erhöhung des Anteils von Bioprodukten in der Kitaverpflegung auf 20% durch Erarbeitung und Anwendung von Arbeitsinstrumenten für die Praxis der verschiedenen Verpflegungssysteme: Öko-Speisenplaner, Beschaffungsleitfaden, Basiszutatenliste. Hypothesen: 1. Die Einführung von Bioprodukten muß in dem derzeit vorgegebenen Preisrahmen erfolgen, da hier keine/wenig Spielräume bestehen 2. Bioprodukte können bei bestehendem Preisrahmen bis zu einem gewissen Anteil eingeführt werden, we...

  17. Investigation of soils contaminated with mineral oil. Estimation of concentrations in soil water by a percolation method; Untersuchung von Mineraloelkontaminationen im Boden. Ableitung der Konzentrationen im Bodenwasser nach einem Perkolationsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Biernath-Wuepping, S. [IGU - Institut fuer Gewaesserschutz und Umgebungsueberwachung Dr. Biernath-Wuepping GmbH, Kiel (Germany); Liphard, K. [Ruhr Analytik Lab. fuer Kohle und Umwelt GmbH, Herne (Germany)

    1998-01-01

    In connection with the national soil protection law (Bundesbodenschutzgesetz) it is planned for risk assessment to estimate concentrations of contaminants in soil water according to the preliminary standard DIN V 19736 (current status: 3rd draft, 1997-04). In this standard a method is described for percolation of soil samples. In this DGMK project the current draft (3rd draft, 1997-04) was applied to soil samples which are contaminated with mineral oil. Another aim of the project was to find a correlation between the soil concentrations and the percolate concentrations. The most important results of this project are: - Soil contaminations with gasoline will be easilier percolated than contaminations with Diesel fuel or lubricants. - No correlation between the concentrations of mineral oil in soil and in percolate could be found. - The procedure described in the preliminary standard (3rd draft, 1997-04) is not useful for a sophisticated assessment of mineral oil contaminations in soils. (orig.) [Deutsch] Das untergesetzliche Regelwerk zum Bundesbodenschutzgesetz wird voraussichtlich zur Bewertung des Gefaehrdungspotentials eine Untersuchung gemaess Vornorm DIN V 19736 (zur Zeit noch Entwurf 04/97) fordern. In ihr wird ein Perkolationsverfahren fuer Bodenproben beschrieben. In diesem DGMK-Vorhaben wurde der zur Zeit vorliegende Entwurf auf seine Anwendbarkeit auf mit Mineraloelkohlenwasserstoffen belastete Boeden geprueft. Weiterhin wurde untersucht, ob es eine Korrelation zwischen den Gehalten im Feststoff und im Perkolat gibt. Die wichtigsten Ergebnisse dieses Vorhabens sind: - Bodenverunreinigungen mit Ottokraftstoffen ergeben in der Regel hoehere Kohlenwasserstoffgehalte im Perkolat als Verunreinigungen mit Dieselkraftstoff oder Schmieroel. - Zwischen den im Boden und im Perkolat gemessenen Kohlenwasserstoffgehalten konnte kein eindeutiger Zusammenhang gefunden werden. - Das im Entwurf DIN V 19736 beschriebene Verfahren ist fuer die differenzierte Bewertung von Mineraloelkohlenwasserstoff-Kontaminationen im Boden nicht geeignet. (orig.)

  18. Timeresolved investigation of atomic order in tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ) monocrystals after excitation with ultrashort light pulses; Zeitaufgeloeste Untersuchung atomarer Ordnung in Tetrathiafulvalen-Tetracyanochinodimethan (TTF-TCNQ)-Einkristallen nach Anregung mit ultrakurzen Lichtpulsen

    Energy Technology Data Exchange (ETDEWEB)

    Sager, Christian

    2011-02-15

    This thesis describes time-resolved investigations of the atomic structure of one-dimensional organic molecular crystals after laser excitation of the photo-induced phase transition. There is a neutral to ionic phase transition in tetrathiafulvalene-chloranil-crystals (TTF-CA-crystals). At this phase transition a Peierls distortion occurs. A new model is introduced, that can explain the photo-induced phase transition in TTF-CY-crystals. This model is called charge density wave model of photo induced structural phase transition. There is a structural phase transition in tetrathiafulvalene-tetracyanochinodimethane-crystals (TTF-TCNQ-crystals). At this phase transition the one-dimensional metal TTF-TCNQ is transformed to an insulator. The phase transition is driven by the Peierls distortion. The charge density wave model is appropriate for description of the processes in TTF-TCNQ-crystals after laser excitation. The results of time-resolved measurements of the structure of TTF-TCNQ-crystals after excitation of the photo-induced phase transition can be anticipated with the charge density wave model. In the basis of these anticipated results, a time-resolved measurement for investigation of the atomic structure of TTF-TCNQ after excitation of the photo-induced phase transition is proposed. The time-resolved measurement should be performed at a beamline of a third generation synchrotron by the optical pump X-ray probe technique. The time-resolved measurement is prepared by an optical characterization and by static X-ray diffraction measurements. The results of the optical characterization and the static X-ray diffraction measurements are presented and analyzed. (orig.)

  19. Characteristics of necrosis after laser-induced thermotherapy in contrast-enhanced MRI and implications for treatment success; Charakteristik von Koagulationsnekrosen nach laserinduzierter Thermotherapie in der kontrastmittelverstaerkten Magnetresonanztomografie und deren Einfluss auf den Therapieerfolg

    Energy Technology Data Exchange (ETDEWEB)

    Kuehn, J.P.; Puls, R.; Rosenberg, C.; Hosten, N. [Institut fuer Diagnostische Radiologie und Neuroradionlogie, Ernst-Moritz-Arndt-Universitaet, Greifswald (Germany); Wallaschowski, H. [Klinik und Poliklinik fuer Innere Medizin A, Ernst-Moritz-Arndt-Universitaet, Greifswald (Germany); Heidecke, C.D. [Klinik und Poliklinik fuer Chirurgie, Abteilung fuer Thorax- und Viszeralchirurgie, Ernst-Moritz-Arndt-Universitaet, Greifswald (Germany)

    2008-09-15

    Aim: This article reports on the use of magnetic resonance imaging to access the post-interventional necrosis volume of liver metastases immediately after and 48 hours after LITT. Material and Methods: In this prospective study, 56 liver metastases from 39 patients (16 females, 23 males, mean age 60.4 years) underwent LITT. The 56 metastases were divided into 4 groups according to the ablation strategy (dependent on multi-applicator technique and laser duration). Groups I and II were treated with an applicator and a time of ablation greater than 15 minutes and 20 minutes, respectively. In groups III and IV the multi-applicator technology with 3 or 4 applicators and a constant ablation time of 20 minutes were used. With the help of heightened contrast MRI of the liver, the portrayal of the post-interventional necrosis was conducted immediately after LITT and 48 hours after LITT. The post-interventional controls after 48 hours were performed during the inpatient stay. The protocol was complemented by an outpatient long-term control after more than 3 months. Results: The local tumor control rate was initially 96.4%. After 3 months it decreased to 92.1%. The mean necrosis volume directly after LITT was: Group I (n = 11; 1 applicator, 30 watt, 10 - 15 minutes) 6.69 cm{sup 3}; Group II (n = 13; 1 applicator, 30 watt, 20 minutes) 10.95 cm{sup 3}; Group III (n = 28; 2 applicator, 30 watt, 10 - 15 minutes) 21.47 cm{sup 3}; Group IV (n = 4; 3 applicator, 30 watt, 20 minutes) 40.20 cm{sup 3}. In comparison, the necrosis volume after 48 hours increased: Group I 10.56 cm{sup 3}; Group II 15.11 cm{sup 3}; Group III 31.33 cm{sup 3}, Group IV 55.73 cm{sup 3}. Conclusion: After 48 hours a progressive increase of post-interventional necrosis volumes compared to volumes directly after LITT was able to be observed. An MRI control after 48 hours, as opposed to an MRI control directly after intervention, is a better indicator for post-interventional success after LITT.

  20. Heiliger Krieg? Die Kriegserzählungen des Alten Israel in den Büchern Josua und Deuteronomium im Spiegel der politischen Reden George W. Bushs nach dem 11. September 2001 und aktueller hermeneutischer Debatten

    OpenAIRE

    Münch-Wirtz, Julia

    2010-01-01

    Spätestens seit dem 11. September 2001 hat der Terminus Heiliger Krieg Hochkonjunktur. Sowohl die immer wiederkehrende Gewalt als auch die signifikante Verbindung von Religion und Politik veranlassen vor allem die alttestamentliche Theologie dazu, diese Thematik zu einem wesentlichen Bestandteil der wissenschaftlichen Reflexion zu machen. In diesem Kontext stellt sich die Frage, was es überhaupt bedeutet, von einem Heiligen Krieg zu sprechen, und aufgrund welcher Konvention oder Tradition...