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Sample records for erwachsenen nach krebs

  1. The risk for cancer and genetic abnormalities after radioiodine treatment of hyperthyroidism; Zum Krebs- und genetischen Risiko nach Radioiodtherapie der Hyperthyreose

    Energy Technology Data Exchange (ETDEWEB)

    Reiners, C. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    1997-12-01

    According to recent studies, the risk for thyroid cancer is not increased after radioiodine treatment in patients with hyperthyroidism. Only the risk of cancer of the stomach seems to be increased slightly in patents treated with I-131 because of functional autonomy. However, the risk for gastric cancer is not increased after higher activities of I-131 because of thyroid cancer. There is no increased risk for genetic abnormalities after radioiodine treatment of hyperthyroidism. (orig.) [Deutsch] Aktuelle Studien zum Karzinomrisiko nach Radioiodtherapie wegen Hyperthyreose ergeben keinen Anhalt fuer eine erhoehte Inzidenz des Schilddruesenkarzinoms nach therapeutischer Gabe von I-131. Allenfalls scheint die Inzidenz von Magenkarzinomen bei Patienten nach Radioiodtherapie wegen funktioneller Autonomie geringfuegig erhoeht zu sein, obwohl diese Beobachtung bei Patienten nach hochdosierter Radioiodtherapie wegen eines Schilddruesenkarzinoms nicht gemacht wurde. Hinweise fuer ein erhoehtes genetisches Risiko nach Radioiodtherapie der Hyperthyreose ergeben sich nicht. (orig.)

  2. Wirksamkeit der Hypnose auf Schmerzen bei Erwachsenen: systematische Literaturreview

    OpenAIRE

    Pfaffen, Céline; Z`Brun-Schnyder, Silvia

    2018-01-01

    Das Ziel dieser systematischen Literaturreview ist es, die Wirksamkeit der Hypnose auf Schmerzen bei Erwachsenen zu überprüfen. Daraus ergibt sich folgende Forschungsfrage: "Wie wird die Wirksamkeit der Hypnose auf Schmerzen bei Erwachsenen in der wissenschaftlichen Literatur beschrieben?"

  3. The Krebs Uric Acid Cycle: A Forgotten Krebs Cycle.

    Science.gov (United States)

    Salway, Jack G

    2018-05-25

    Hans Kornberg wrote a paper entitled 'Krebs and his trinity of cycles' commenting that every school biology student knows of the Krebs cycle, but few know that Krebs discovered two other cycles. These are (i) the ornithine cycle (urea cycle), (ii) the citric acid cycle (tricarboxylic acid or TCA cycle), and (iii) the glyoxylate cycle that was described by Krebs and Kornberg. Ironically, Kornberg, codiscoverer of the 'glyoxylate cycle', overlooked a fourth Krebs cycle - (iv) the uric acid cycle. Copyright © 2018 Elsevier Ltd. All rights reserved.

  4. Narrative Expositionstherapie (NET) für Menschen nach Gewalt und Flucht : Ein Einblick in das Verfahren

    OpenAIRE

    Schauer, Maggie; Elbert, Thomas; Neuner, Frank

    2017-01-01

    Die Narrative Expositionstherapie (NET) ist ein effizientes Kernelement der Behandlung von Kindern und Erwachsenen, die unter den Folgen von Mehrfach- und Komplextraumatisierung nach Gewalt und Flucht leiden. Die chronologische Erarbeitung einer Narration, der individuellen Lebensgeschichte in der NET ermöglicht Traumaüberlebenden eine Gesamtschau ihres Lebens und so die Integration der Lebenserfahrungen in den biografischen Zusammenhang. Sie aktiviert Ressourcen und erlaubt korrigierende Bez...

  5. Azelainsäure 20 % Creme: Auswirkung auf Lebensqualität und Krankheitsaktivität bei erwachsenen Patientinnen mit Acne vulgaris.

    Science.gov (United States)

    Kainz, Julius Thomas; Berghammer, Gabriele; Auer-Grumbach, Piet; Lackner, Verena; Perl-Convalexius, Sylvia; Popa, Rodica; Wolfesberger, Barbara

    2016-12-01

    Zur Wirksamkeit von Aknetherapien und deren Auswirkungen auf die Lebensqualität erwachsener Patienten liegen kaum Daten vor. ZIEL: Erhebung der Wirkung von Azelainsäure 20 % Creme (Skinoren ® ) auf Akne-Schweregrad und krankheitsbedingte Lebensqualität. Nichtinterventionelle Studie bei erwachsenen Patientinnen mit leichter bis mittelschwerer Akne. Wirksamkeitsparameter waren DLQI sowie Akne-Schweregrad im Gesicht, am Dekolleté sowie am Rücken im Gesamturteil des Prüfarztes (IGA-Skala: Grad 1 = annähernd reine Haut; 2 = leichte Akne; 3 = mittelschwere Akne). Visiten waren zu Studienbeginn sowie nach 4-8 und zwölf Wochen geplant. Von den 251 eingeschlossenen Patientinnen lag zu Studienbeginn bei 59 %, 31 % bzw. 10 % ein IGA-Grad von 1, 2 bzw. 3 vor; die am häufigsten betroffene Hautpartie war das Gesicht (IGA-Grad 2 oder 3: 79 %). Nach zwölf Behandlungswochen war eine signifikante Besserung der Acne vulgaris im Gesicht (IGA-Grad 0 oder 1: 82 %) sowie auf Dekolleté und Rücken feststellbar. Der mediane DLQI-Wert sank von neun zu Studienbeginn auf fünf nach zwölf Behandlungswochen. Neunzig Prozent der behandelnden Ärzte und Patientinnen beurteilten die Verträglichkeit der Behandlung als sehr gut oder gut. Die Anwendung von 20%iger Azelainsäure-Creme führt bei erwachsenen Frauen zu einer signifikanten Besserung der Acne vulgaris und der krankheitsbedingten Lebensqualität. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  6. Einsatz und Wirksamkeit von Systemtherapien bei Erwachsenen mit schwerer Neurodermitis: Erste Ergebnisse des deutschen Neurodermitis-Registers TREATgermany.

    Science.gov (United States)

    Schmitt, Jochen; Abraham, Susanne; Trautmann, Freya; Stephan, Victoria; Fölster-Holst, Regina; Homey, Bernhard; Bieber, Thomas; Novak, Natalija; Sticherling, Michael; Augustin, Matthias; Kleinheinz, Andreas; Elsner, Peter; Weidinger, Stephan; Werfel, Thomas

    2017-01-01

    Versorgungsregister dienen der Erfassung des Einsatzes und der Wirksamkeit von Therapien unter realen Versorgungsbedingungen und sind als Basis einer evidenzbasierten Gesundheitsversorgung unverzichtbar. Das deutsche Neurodermitis-Register TREATgermany wurde als weltweit erstes Register für Patienten mit schwerer Neurodermitis 2011 initiiert. Erwachsene mit schwerer Neurodermitis (aktuelle/frühere antientzündliche Systemtherapie und/oder objektiver SCORAD ≥ 40) werden über einen Zeitraum von 24 Monaten prospektiv beobachtet. Anhand validierter Erhebungsinstrumente werden die klinische Erkrankungsschwere (EASI, SCORAD), Lebensqualität (DLQI), Symptome, globale Erkrankungsschwere sowie die Patientenzufriedenheit erfasst und die durchgeführten Therapien dokumentiert. Die vorliegende Analyse beschreibt die Charakteristika, Therapiewahl und Wirksamkeit der eingesetzten antiinflammatorischen Systemtherapien der bis Oktober 2014 eingeschlossenen Patienten. An fünf Zentren wurden insgesamt 78 Patienten (Durchschnittsalter 39 Jahre, 61 % männlich) eingeschlossen. Bei den Patienten besteht eine hohe Inanspruchnahme ambulanter und stationärer Leistungen. Ciclosporin war das am häufigsten eingesetzte Systemtherapeutikum und zeigte die höchste klinische Effektivität (EASI-50-Ansprechrate 51 %; EASI-75-Ansprechrate 34 % nach zwölfwöchiger Therapie). Azathioprin, Methotrexat (MTX), Prednisolon oral, Mycophenolat, Alitretinoin und Leflunomid wurden ebenfalls bei einzelnen Patienten eingesetzt. Die vorliegende Registerauswertung gibt wichtige Hinweise zur derzeitigen Versorgung von Erwachsenen mit schwerer Neurodermitis in Deutschland, dokumentiert die hohe Erkrankungslast, den Nutzen vorhandener Therapien und den Bedarf an weiteren, effektiven und in der Langzeitanwendung sicheren Therapieoptionen. © 2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  7. Systemic cancer multistep therapy; Systemische Krebs-Mehrschritt-Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Weigang-Koehler, K. [Medizinische Klinik 5, Arbeitsgruppe Biologische Krebstherapie, Staedtisches Klinikum Nuernberg (Germany); Kaiser, G. [Medizinische Klinik 5, Arbeitsgruppe Biologische Krebstherapie, Staedtisches Klinikum Nuernberg (Germany); Gallmeier, W.M. [Medizinische Klinik 5, Arbeitsgruppe Biologische Krebstherapie, Staedtisches Klinikum Nuernberg (Germany)

    1997-04-11

    To get an insight into the claimed efficacy of `systemic cancer multistep therapy` (sKMT) with hyperglycemia, whole-body hyperthermia and hyperoxemia, we conducted a best case analysis with 20 patients who had received sKMT alone (9 patients) or in combination with chemo- or radiotherapy (11 patients). There was no complete remission or an unquestionable partial remission when sKMT was used alone. When sKMT was combined with classical effective therapies like chemo- and radiotherapy, 1 patient had questionable complete remission and 3 patients had partial remission. In these three patients sKMT had been combined with a newly applied chemotherapy: Therefore, it remains unclear which method was effective in causing the remission. (orig.) [Deutsch] Um eine Ueberblick ueber die behauptete Wirksamkeit der systemischen Krebs-Mehrschritt-Therapie (sKMT) nach von Ardenne zu erlangen, fuehrten wir eine Best-case-Analyse bei 20 Patienten durch, die die sKMT ohne Chemotherapie (9 Patienten) und in Kombination mit Chemo- bzw. Strahlentherapie (11 Patienten) erhalten hatten. sKMT allein hatte zu keiner kompletten Remission oder sicheren partiellen Remission gefuehrt. Bei der Kombination von sKMT mit klassischen Therapieverfahren wie Chemotherapie und Bestrahlung trat bei einem Patienten eine fragliche komplette Remission ein sowie bei 3 Patienten eine partielle Remission. Im letzteren Fall war jeweils eine fuer den Patienten neue Chemotherapie mit der sKMT kombiniert worden, so dass unklar bleibt, was die Verbesserung herbeifuehrte. (orig.)

  8. Modelling the Krebs cycle and oxidative phosphorylation.

    Science.gov (United States)

    Korla, Kalyani; Mitra, Chanchal K

    2014-01-01

    The Krebs cycle and oxidative phosphorylation are the two most important sets of reactions in a eukaryotic cell that meet the major part of the total energy demands of a cell. In this paper, we present a computer simulation of the coupled reactions using open source tools for simulation. We also show that it is possible to model the Krebs cycle with a simple black box with a few inputs and outputs. However, the kinetics of the internal processes has been modelled using numerical tools. We also show that the Krebs cycle and oxidative phosphorylation together can be combined in a similar fashion - a black box with a few inputs and outputs. The Octave script is flexible and customisable for any chosen set-up for this model. In several cases, we had no explicit idea of the underlying reaction mechanism and the rate determining steps involved, and we have used the stoichiometric equations that can be easily changed as and when more detailed information is obtained. The script includes the feedback regulation of the various enzymes of the Krebs cycle. For the electron transport chain, the pH gradient across the membrane is an essential regulator of the kinetics and this has been modelled empirically but fully consistent with experimental results. The initial conditions can be very easily changed and the simulation is potentially very useful in a number of cases of clinical importance.

  9. Die Frage nach Gerechtigkeit.

    Directory of Open Access Journals (Sweden)

    Martin Jäggle

    2014-07-01

    Full Text Available ENGLISH: In the first part six stages in the author’s path of life are described, which have influenced his engagement with justice. The second part gives an insight into his religious educational work, in which the issue of justice was especially significant on the example of ‘religion in the context of migration’ and of the ecumenic initiative ‘lebens.werte.schule’ (school worth living. The vision of the Kingdom of God and the necessity of participation become apparent. DEUTSCH: Im ersten Teil werden sechs Stationen am Lebensweg des Autors beschrieben, die seine Auseinandersetzung mit Gerechtigkeit geprägt haben. Der zweite Teil gibt Einblick in seine religionspädagogische Arbeit, in der die Frage nach Gerechtigkeit besonders bedeutsam war am Beispiel ‚Religion im Kontext Migration‘ und der ökumenischen Initiative ‚lebens.werte.schule‘. Die Vision vom Reich Gottes und die Notwendigkeit von Partizipation werden dabei deutlich.

  10. Magnetic resonance imaging of complex congenital heart disease in aduits; Magnetresonanztomographie komplexer kongenitaler Herzerkrankungen beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Bremerich, J. [San Francisco Univ, CA (United States). Dept. of Radiology]|[Universitaetsklinik Basel (Switzerland). Abt. fuer Medizinische Radiologie; Wyttenbach, R.; Higgins, C.B. [San Francisco Univ, CA (United States). Dept. of Radiology; Buser, P. [Universitaetsklinik Basel (Switzerland). Abt. fuer Kardiologie; Steinbrich, W. [Universitaetsklinik Basel (Switzerland). Abt. fuer Medizinische Radiologie

    1999-04-01

    An increasing number of patients with complex congenital heart disease reaches adulthood, because treatment and patient outcome have improved considerably in recent years. Monitoring of these patients requires both definition of cardiac anatomy and assessment of function with good reproducibility. Complications after surgical repair such as restenoses of pulmonary arteries after surgical repair of Tetralogy of Fallot, ventricular hypertrophy, stenoses or leakage of baffles, or stenosis and aneurysms of anastomoses have to be detected at an early stage. Magnetic Resonance Imaging (MRI) is an excellent tool to monitor these patients because of its noninvasive nature, its good interstudy and interobserver reproducibility, and because it allows assessment of both cardiac anatomy and function. This paper reviews the current applications of MRI in complex congenital heart disease in adults. (orig.) [Deutsch] Durch Verbesserungen in der Diagnose und Therapie komplexer kongenitaler Herzerkrankungen kann eine zunehmende Anzahl von betroffenen Patienten das Erwachsenenalter erreichen. Diese Patienten benoetigen regelmaessige postoperative Verlaufskontrollen, um Komplikationen wie z.B. Restenosen der grossen Arterien, Stenosen, Lecks und Aneurysmata von Anastomosen, Ventrikelhypertrophie und -dilatation oder Klappendysfunktionen fruehzeitig zu erkennen und zu behandeln. Fuer nichtinvasive regelmaessige Verlaufskontrollen bietet sich die Magnetresonanztomographie (MRT) des Herzens an, da sie eine umfassende Untersuchung sowohl der Morphologie als auch der Funktion des Herzens mit guter Reproduzierbarkeit erlaubt. Die gegenwaertigen klinischen Anwendungen der MRT bei komplexen kongenitalen Herzerkrankungen beim Erwachsenen werden in dieser Uebersicht beschrieben. (orig.)

  11. Von Kalifornien nach Taxham / Katri Soe

    Index Scriptorium Estoniae

    Soe, Katri, 1971-

    2005-01-01

    Neljas osa magistritööst "Von Kalifornien nach Taxham: Formen und Strukturen der Kommunikation in Peter Handkes Romanen "Der kurze Brief zum langen Abschied" und "In einer dunklen Nacht ging ich aus meinem stillen Haus"" (Tartu, 2000. Juhendaja: Claus Sommerhage)

  12. Bewegungseinschränkung nach vorderer Kreuzbandrekonstruktion

    OpenAIRE

    Weig, Thomas G.

    2002-01-01

    5. Zusammenfassung: 223 Patienten , die sich einer Revision bei Bewegungseinschränkung nach Vorderer Kreuzbandrekonstruktion unterzogen hatten , wurden nachuntersucht. Es wurde eine Arthrofibrosegruppe (n=156; 70%) und eine Cyclops-Gruppe (n=67; 30%) gebildet. Es bestand ein durchschnittlicher Zeitraum zwischen Arthrolyse und Nachuntersuchung von 4,29 Jahren. Der Zeitabstand zwischen Unfall und vorderer Kreuzbandplastik, die Begleitverletzungen, der Reizzustand, die Schme...

  13. A reverse KREBS cycle in photosynthesis: consensus at last

    Science.gov (United States)

    Buchanan, B. B.; Arnon, D. I.

    1990-01-01

    The Krebs cycle (citric acid or tricarboxylic acid cycle), the final common pathway in aerobic metabolism for the oxidation of carbohydrates, fatty acids and amino acids, is known to be irreversible. It liberates CO2 and generates NADH whose aerobic oxidation yields ATP but it does not operate in reverse as a biosynthetic pathway for CO2 assimilation. In 1966, our laboratory described a cyclic pathway for CO2 assimilation (Evans, Buchanan and Arnon 1966) that was unusual in two respects: (i) it provided the first instance of an obligate photoautotroph that assimilated CO2 by a pathway different from Calvin's reductive pentose phosphate cycle (Calvin 1962) and (ii) in its overall effect the new cycle was a reversal of the Krebs cycle. Named the 'reductive carboxylic acid cycle' (sometimes also called the reductive tricarboxylic acid cycle) the new cycle appeared to be the sole CO2 assimilation pathway in Chlorobium thiosulfatophilum (Evans et al. 1966) (now known as Chlorobium limicola forma thiosulfatophilum). Chlorobium is a photosynthetic green sulfur bacterium that grows anaerobically in an inorganic medium with sulfide and thiosulfate as electron donors and CO2 as an obligatory carbon source. In the ensuing years, the new cycle was viewed with skepticism. Not only was it in conflict with the prevailing doctrine that the 'one important property ... shared by all (our emphasis) autotrophic species is the assimilation of CO2 via the Calvin cycle' (McFadden 1973) but also some of its experimental underpinnings were challenged. It is only now that in the words of one of its early skeptics (Tabita 1988) 'a long and tortuous controversy' has ended with general acceptance of the reductive carboxylic acid cycle as a photosynthetic CO2 assimilation pathway distinct from the pentose cycle. (Henceforth, to minimize repetitiveness, the reductive pentose phosphate cycle will often be referred to as the pentose cycle and the reductive carboxylic acid cycle as the carboxylic

  14. Zukunftssicherung für die Zeit nach der Krise

    OpenAIRE

    Ackermann, Karl-Friedrich; Wehner, Martina

    2009-01-01

    Die Studie berichtet zusammenfassend über die Ergebnisse der 9. HR-Expertenbefragung mit der Zeitschrift „Personalwirtschaft“ zum Thema „Employer Branding“. Berichtet wird über die Verbreitung des Employer Branding, die dabei verfolgten Ziele und die Instrumente, mit denen ein erfolgreiches Employer Branding realisiert werden kann. Eng damit verbunden sind ergänzende Fragen nach den Einflussfaktoren und den Gestaltungsmöglichkeiten der Arbeitgebermarke sowie nach den eingesetzten Methoden zur...

  15. Zuwanderung nach Österreich. Integrationspolitische Herausforderungen

    Directory of Open Access Journals (Sweden)

    Heinz Faßmann

    2016-12-01

    Full Text Available ENGLISH: Since the early 1960ies, Austria has become an immigration country against its will. In the beginning, the migration of Guestworkerswas a flexible supplement of the national labour market. Gradually it developed towards a permanent immigration.With the accession to the European Union Austria became a part of the common European migration era. The immigration fromthird countries lost importance, the immigration from other member states gained. Beside, Austria was always a target countryfor asylum seekers. The structural characteristics of the immigrants as well as the historical context showed some changes. Therefore,the integration processes happened differently. While the integration of the immigrants from other member states –especially from Germany – performed conflict – free and quick, the integration of the guestworkers and their descendants proceededonly stepwise. A similar stepwise and long lasting integration process can be expected for the asylum seekers due totheir qualification and their cultural background. Therefore, the cultural diversity will increase and it is not always an enrichmentonly, but also a reason of conflicts about the valid societal perspectives. DEUTSCH: Österreich hat sich seit den 1960er zu einem Einwanderungsland wider Willen entwickelt. Anfangs war die Zuwanderung vonGastarbeiterInnen eine flexible Ergänzung des nationalen Arbeitsmarktes. Nach und nach entwickelte sich daraus aber eine dauerhafteZuwanderung. Mit dem Beitritt zur Europäischen Union wurde Österreich auch Teil eines Europäischen Wanderungsraums.Die Zuwanderung aus den Drittstaaten verlor an Bedeutung, die Zuwanderung aus anderen Mitgliedstaaten der EuropäischenUnion wurde wichtiger. Daneben war Österreich auch immer wieder Aufnahmeland von Asylwerbern. Die strukturellenMerkmale der Zugewanderten und der zeitliche Kontext der Zuwanderung waren ungleich. Daher verliefen auch die Integrationsprozessesehr unterschiedlich. W

  16. Should Kohlberg's Cognitive Developmental Approach to Morality Be Replaced with a More Pragmatic Approach? Comment on Krebs and Denton (2005)

    Science.gov (United States)

    Gibbs, John C.

    2006-01-01

    Krebs and Denton (2005; see record 2005-08166-005) proposed that Kohlberg's cognitive developmental approach to morality be replaced by a pragmatic approach more relevant to everyday social behavior and the cooperative moral orders of society. Although the Krebs and Denton article raises some legitimate questions, their proposal is at best…

  17. Mutations in MDH2, Encoding a Krebs Cycle Enzyme, Cause Early-Onset Severe Encephalopathy

    NARCIS (Netherlands)

    Ait-El-Mkadem, Samira; Dayem-Quere, Manal; Gusic, Mirjana; Chaussenot, Annabelle; Bannwarth, Sylvie; François, Bérengère; Genin, Emmanuelle C; Fragaki, Konstantina; Volker-Touw, Catharina L M; Vasnier, Christelle; Serre, Valérie; van Gassen, Koen L I; Lespinasse, Françoise; Richter, Susan; Eisenhofer, Graeme; Rouzier, Cécile; Mochel, Fanny; De Saint-Martin, Anne; Abi Warde, Marie-Thérèse; de Sain-van der Velden, Monique G M; Jans, Judith J M; Amiel, Jeanne; Avsec, Ziga; Mertes, Christian; Haack, Tobias B; Strom, Tim; Meitinger, Thomas; Bonnen, Penelope E; Taylor, Robert W; Gagneur, Julien; van Hasselt, Peter M; Rötig, Agnès; Delahodde, Agnès; Prokisch, Holger; Fuchs, Sabine A; Paquis-Flucklinger, Véronique

    2016-01-01

    MDH2 encodes mitochondrial malate dehydrogenase (MDH), which is essential for the conversion of malate to oxaloacetate as part of the proper functioning of the Krebs cycle. We report bi-allelic pathogenic mutations in MDH2 in three unrelated subjects presenting with early-onset generalized

  18. Metabolism: Part II. The Tricarboxylic Acid (TCA), Citric Acid, or Krebs Cycle.

    Science.gov (United States)

    Bodner, George M.

    1986-01-01

    Differentiates the tricarboxylic acid (TCA) cycle (or Krebs cycle) from glycolysis, and describes the bridge between the two as being the conversion of pyruvate into acetyl coenzyme A. Discusses the eight steps in the TCA cycle, the results of isotopic labeling experiments, and the net effects of the TCA cycle. (TW)

  19. Procyclic Trypanosoma brucei do not use Krebs cycle activity for energy generation

    NARCIS (Netherlands)

    Weelden, van S.W.H.; Fast, B.; Vogt, A.; Meer, van der P.; Saas, J.; Hellemond, van J.J.; Tielens, A.G.M.; Boshart, M.

    2003-01-01

    The importance of a functional Krebs cycle for energy generation in the procyclic stage of Trypanosoma brucei was investigated under physiological conditions during logarithmic phase growth of a pleomorphic parasite strain. Wild type procyclic cells and mutants with targeted deletion of the gene

  20. THE EVOLUTION OF THE KREBS CYCLE: A PROMISING THEME FOR MEANINGFUL BIOCHEMISTRY LEARNING IN BIOLOGY

    Directory of Open Access Journals (Sweden)

    C. Costa

    2015-08-01

    Full Text Available INTRODUCTION: Evolution has been recognized as a key concept for biologists. In order to motivate biology undergraduates for contents of central energetic metabolism, we addressed the Krebs cycle structure and functions to an evolutionary view. To this end, we created a study guide which contextualizes the emergence of the cyclic pathway, in light of the prokaryotic influence since early Earth anaerobic condition to oxygen rise in atmosphere. OBJECTIVES: The main goal is to highlight the educational potential of the material whose subject is scarcely covered in biochemistry textbooks. MATERIALS AND METHODS: The study guide is composed by three interrelated sections, the problem (Section 1, designed to arouse curiosity, inform and motivate students; an introductory text (Section 2 about life evolution, including early micro-organisms and Krebs cycle emergence, and questions (Section 3 for debate. The activity consisted on a peer discussion session, with instructors tutoring. The questions were designed to foster exchange of ideas in an ever-increasing level of complexity, and cover subjects from early atmospheric conditions to organization of the metabolism along the subsequent geological ages. RESULTS AND DISCUSSION: We noticed that students were engaged and motivated by the task, especially during group discussion. Based on students’ feedbacks and class observations, we learned that the material raised curiosity and stimulated discussion among peers. It brought a historical and purposeful way of dealing with difficult biochemical concepts. CONCLUSIONS: The whole experience suggests that the study guide was a stimulus for broadening comprehension of the Krebs cycle, reinforcing the evolutionary stance as an important theme for biology and biochemistry understanding. On the other hand, we do not underestimate the fact that approaching Krebs cycle from an evolutionary standpoint is a quite complex discussion for the majority of students

  1. Increased efficiency of exogenous messenger RNA translation in a Krebs ascites cell lysate.

    Science.gov (United States)

    Metafora, S; Terada, M; Dow, L W; Marks, P A; Bank, A

    1972-05-01

    Addition of a 0.5 M KCl wash fraction from rabbit reticulocyte ribosomes causes a 3- to 10-fold increase in the extent of translation of natural mRNAs by Krebs-cell lysates. In the presence of the wash fraction, 1 pmol of rabbit or mouse 10S RNA directs the incorporation of 80 pmol of leucine into rabbit globin. The addition of human 10S RNA results in the synthesis of equal amounts of human alpha and beta chains, identified by column chromatography. The stimulation by the wash fraction is almost completely dependent on added mammalian tRNA. In contrast to the wash fraction from rabbit reticulocytes, the wash fraction isolated from Krebs-cell ribosomes is inhibitory to both endogenous and exogenous mRNA translation. The stimulation by the wash fraction from rabbit ribosomes is not specific for globin mRNAs, but also increases endogenous, phage Qbeta, and viral RNA-directed protein synthesis.

  2. 76 FR 77696 - Establishment of the Naches Heights Viticultural Area

    Science.gov (United States)

    2011-12-14

    ... Decision. SUMMARY: This final rule establishes the 13,254-acre ``Naches Heights'' viticultural area in... origin of their wines and to allow consumers to better identify wines they may purchase. DATES: Effective... consumers to identify wines they may purchase. Establishment of a viticultural area is neither an approval...

  3. The evolution of the Krebs cycle: A promising subject for meaningful learning of biochemistry.

    Science.gov (United States)

    da Costa, Caetano; Galembeck, Eduardo

    2016-05-06

    Evolution has been recognized as a key concept for biologists. To enhance comprehension and motivate biology undergraduates for the contents of central energetic metabolism, we addressed the Krebs cycle structure and functions in an evolutionary view. To this end, we created a study guide that contextualizes the emergence of the cyclic pathway, in light of the prokaryotic influence since the early anaerobic condition of the Earth to increase oxygen in the atmosphere. The study guide is composed of three interrelated sections: (1) a problem, designed to arouse curiosity, inform and motivate students, (2) a text about life evolution, including early microorganisms and the emergence of the Krebs cycle, and (3) questions for debate. The activity consisted on individual reading and peer discussion based on this written material, under the guidance of the instructors. The questions were designed to foster debate in an ever-increasing level of complexity and to strengthen the main contextual aspects leading to emergence, evolving, and permanency of a complex metabolic pathway. Based on classroom observation, analysis of student's written responses, and individual interviews, we noticed they were engaged and motivated by the task, especially during group discussion. The whole experience suggests that the study guide was a stimulus to broaden the comprehension of the Krebs cycle, reinforcing the evolutionary approach as an important subject for learning purposes. © 2016 by The International Union of Biochemistry and Molecular Biology, 44:288-296, 2016. © 2016 The International Union of Biochemistry and Molecular Biology.

  4. Non-traumatic avascular necrosis of the hip in the adult. Pt. 2. Radiological diagnosis and staging; Die nichttraumatische Hueftkopfnekrose des Erwachsenen. T. 2. Radiologische Diagnostik und Stadieneinteilung

    Energy Technology Data Exchange (ETDEWEB)

    Kramer, J [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). MR-Institut, Abteilung fuer Osteologie; Hofmann, S [Orthopaedisches Krankenhaus Gersthof, Wien (Austria). 1. Abteilung; Imhof, H [Universitaetsklinik fuer Radiodiagnostik, Wien (Austria). MR-Institut, Abteilung fuer Osteologie

    1994-01-01

    In recent years diagnosis, and in particular early diagnosis, of osteonecrosis of the hip has been much improved by modern imaging modalities. Magnetic resonance imaging is widely accepted as the primary imaging modality for the early detection of this disorder and can help to facilitate the therapeutic management in later stages. However, plain radiographs, bone scans and computed tomography are still important techniques, which cannot be avoided in most cases. This paper describes the relative values of the different modalities. The staging system used is the international ARCO system. (orig.) [Deutsch] Die Diagnose und insbesondere die Frueherkennung der Hueftkopfnekrose hat sich in den letzten Jahren durch den Einsatz der modernen bildgebenden Verfahren entscheidend verbessert. Die Magnetresonanztomographie hat sich mittlerweile zur Methode der Wahl entwickelt und wird sowohl zur Fruehdiagnostik als auch in spaeteren Stadien zur Therapieplanung eingesetzt. Trotzdem kann auf die anderen Methoden wie Nativroentgen, Szintigraphie und Computertomographie vielfach nicht verzichtet werden. Diese Arbeit beschreibt die Wertigkeit der verschiedenen radiologischen Methoden bei der nichttraumatischen HKN des Erwachsenen, wobei die internationale klinische ARCO-Stadieneinteilung verwendet wird. (orig.)

  5. EFEITO DE INTERMEDIÁRIOS DO CICLO DE KREBS SOBRE ALTERAÇÕES OXIDATIVAS INDUZIDAS POR DIFERENTES AGENTES OXIDANTES

    OpenAIRE

    Robson Luiz Puntel

    2006-01-01

    Dados recentes na literatura têm relatado que alguns intermediários do ciclo de Krebs podem agir como potentes antioxidantes, tanto in vitro, quanto in vivo, em diversos sistemas pró-oxidantes. Porém, o(s) mecanismo(s) através dos qual(is) os intermediários do ciclo de Krebs exercem suas atividades antioxidantes não são completamente entendidas. Considerando a escassez de dados in vitro na literatura a respeito do efeito desses intermediários durante situações de estresse oxidativo, o present...

  6. Person, Profil, Privatheit. Die Suche nach Eigennamen als informationsethisches Problem

    OpenAIRE

    Bordat, Josef

    2005-01-01

    Zusammenfassung: Der Schutz der Privatsphäre im Rahmen der Nutzung von Internet-Suchmaschinen wird auf der Ebene der privacy als Recht auf wirksamen Schutz seiner Daten und der Privatheit als Recht des "Für-Sich-Seins", auf "solitude, anonymity and intimacy" sowie auf "control of personal information" untersucht. Gerade letztere gerät im Zusammenhang mit der Suche nach Eigennamen in Gefahr, da im Ergebnis über persönliche Daten verfügt wird, ohne das die betreffende Person weiß, wer zu wel...

  7. A Role for the Krebs Cycle Intermediate Citrate in Metabolic Reprogramming in Innate Immunity and Inflammation

    Directory of Open Access Journals (Sweden)

    Niamh C. Williams

    2018-02-01

    Full Text Available Metabolism in immune cells is no longer thought of as merely a process for adenosine triphosphate (ATP production, biosynthesis, and catabolism. The reprogramming of metabolic pathways upon activation is also for the production of metabolites that can act as immune signaling molecules. Activated dendritic cells (DCs and macrophages have an altered Krebs cycle, one consequence of which is the accumulation of both citrate and succinate. Citrate is exported from the mitochondria via the mitochondrial citrate- carrier. Cytosolic metabolism of citrate to acetyl-coenzyme A (acetyl-CoA is important for both fatty-acid synthesis and protein acetylation, both of which have been linked to macrophage and DC activation. Citrate-derived itaconate has a direct antibacterial effect and also has been shown to act as an anti-inflammatory agent, inhibiting succinate dehydrogenase. These findings identify citrate as an important metabolite for macrophage and DC effector function.

  8. 76 FR 30060 - Proposed Establishment of the Naches Heights Viticultural Area (2009R-107P)

    Science.gov (United States)

    2011-05-24

    ... acres of wine grape producing vines. Name Evidence The ``Naches Heights'' name applies to an elevated... carved much of the basin geography within the Columbia Valley AVA. The proposed Naches Heights.... Distinguishing Features The petition states that geology, geography, and soils distinguish the proposed...

  9. Suche nach Charginos in 4 Jet Ereignissen bei LEP2

    CERN Document Server

    AUTHOR|(CDS)2086503

    1997-01-01

    Zum heutigen Tag sind der Hochenergiephysik einige Hundert Teilchen und Teilchenzustände bekannt, die dem Anschein nach auf sehr komplexe Weise wechselwirken und so die beobachtbare Welt konstituieren. Bei näherer Betrachtung sind jedoch nur wenige Teilchen und Wechselwirkungen elementar, in dem Sinne, dass die übrigen sich als aus ihnen zusammengesetzt ansehen lassen. Die Frage, wie man diese elementaren Teilchen und ihre fundamentalen Wechselwirkungen systematisch beschreiben kann, beantwortet das Standardmodell der Elementarteilchenphysik. Es verwendet das Spektrum der fundamentalen Materie, die inneren Symmetrieeigenschaften dieses Spektrums und das Eichprinzip, um eine Beschreibung im Rahmen der Quantenfeldtheorie zu formalisieren. Das Standardmodell leistet so eine prinzipielle Beschreibung der bis heute betrachteten Hochenergiephysik. Dabei treten allerdings einige Probleme auf, die es attraktiv erscheinen lassen, das Standardmodell um eine weitere Symmetrieeigenschaft zu erweitern, nämlich um die ...

  10. Long-term results after fibroid embolization; Langzeitergebnisse nach Myomembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Mueller-Huelsbeck, S. [Medizinischer Klinikverbund Flensburg, Akademisches Lehrkrankenhaus des Universitaetsklinikums Schleswig-Holstein, Abt. Diagnostische und interventionelle Radiologie/Neuroradiologie, Ev.-Luth. Diakonissenanstalt zu Flensburg, Flensburg (Germany)

    2008-07-15

    Fibroids (leiomyoma) are the most frequent benign tumors of the uterus during female reproductive age. In the case of clinical symptoms, uterine artery embolization (UAE) is a well established treatment option for symptomatic fibroids, resulting in promising long-term results. In order to estimate long-term success after UAE, reduction of fibroids and uterus volume is less important than complete improvement and disappearance of fibroid-related symptoms. In addition to a high technical success rate and a low perioperative complication rate, UAE results in high short-term and long-term patient satisfaction (>87%) and improvement of symptoms (>81%). Candidates for UAE should be informed about potential reinterventions in terms of repeated UAE (up to 18% of cases) or surgical treatment options. (orig.) [German] Myome sind die haeufigsten gutartigen soliden Tumoren des weiblichen Genitaltrakts im reproduktiven Alter. Bei klinischen Beschwerden stellt die Uterusarterienembolisation (UAE) zur Therapie des symptomatischen Uterus myomatosus einen fest etabliertes Verfahren dar, das mit viel versprechenden Langzeitergebnissen aufwarten kann. Im Vordergrund der Abschaetzung eines lang andauernden Therapieerfolgs nach UAE stehen weniger die Volumenreduktion eines dominanten Myoms bzw. des gesamten Uterus nach der Behandlung, sondern vielmehr die Besserung oder das voellige Verschwinden der von der Patientin initial vor der UAE angegebenen (myombedingten) Beschwerden. Neben einer hohen technischen Erfolgsrate und geringen perioperativen Komplikationsrate fuehrt die fachkundig durchgefuehrte UAE sowohl im Kurz- als auch Langzeitverlauf zu einem hohen Mass an Patientenzufriedenheit (>87%), verbunden mit einer deutlichen Symptombesserung (>81%). Ueber eine Reintervention (in bis zu ca. 18% der Faelle) im Sinne einer erneuten UAE oder einer operativen Massnahme sollten die Patientinnen allerdings im Vorfeld aufgeklaert werden. (orig.)

  11. Distribution of copper-64 in control mice and in mice bearing ascitic Krebs tumor cells

    International Nuclear Information System (INIS)

    Apelgot, S.; Coppey, J.; Grisvard, J.; Guille, E.; Sissoeeff, I.

    1981-01-01

    Three to 20 hr after an i.p. injection of 64 Cu (half-life, 12.8 hr) into mice bearing Krebs ascites cells, a high amount of the radioisotope was recovered in the ascites cells themselves. In the control group, the radioisotope was mainly present in the liver. Similar amounts of 64 Cu were recovered in regenerating as well as in normal liver, whereas in the liver of mice bearing ascites cells, this amount was lower by 40 to 50% regardless of the ascitic volume. Thus, the copper metabolism seems to be disturbed at the hepatic level in mice bearing ascites cells. The distribution of 64 Cu was 'analyzed in DNA, RNA, and proteins from cellular lysates fractionated by CsCl gradient. There was a uniform pattern of distribution in the macromolecules from ascites cells, while 64 Cu' was preferentially associated with the protein fraction from liver. Further experiments indicated that, in vivo, 64 Cu was bound to the DNA of ascites cells

  12. Signale ohne Antwort? Die Suche nach außerirdischem Leben.

    Science.gov (United States)

    Davoust, E.

    This book is a German translation, by M. Röser, of the English version "The cosmic water hole", published in 1991 (see 53.003.080). The original French edition "Silence au point d'eau" was published in 1988 (see 45.003.059). Contents: I. Leben auf der Erde. 1. Kometen und der Ursprung des Lebens. 2. Die zeitliche Dimension des Lebens. 3. Evolution und Katastrophen. 4. Liegt unsere Zukunft im Weltall? II. Leben im Universum. 5. Die Suche nach Leben in der Sonnenumgebung. 6. Die Suche nach Planetensystemen. III. Intelligentes Leben im Universum. 7. Demographie außerirdischer Zivilisationen. 8. Soziologie außerirdischer Zivilisationen. 9. UFO's und Besuche in der Vergangenheit. 10. Strategien bei der Suche nach außerirdischen Zivilisationen. 11. Die Suche nach künstlichen Signalen. 12. Die Diskussion innerhalb der Gesellschaft. 13. Die Stellung des Menschen im Universum.

  13. Zwischenberichterstattung nach Börsenrecht, DRS, IAS und US-GAAP

    OpenAIRE

    Alvarez von Zerboni di Sposetti, Manuel

    2003-01-01

    Zwischenberichterstattung nach Börsenrecht, DRS, IAS und US-GAAP / von Manuel Alvarez und Stefan Wotschofsky. - 2., neubearb. und erw. Aufl. - Berlin : Erich Schmidt, 2003. - XX, 219 S. [1. Aufl. 2000

  14. 2012 Puget Sound LiDAR Consortium (PSLC) Topographic LiDAR: Upper Naches River, Washington

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Watershed Sciences, Inc. (WSI) collected Light Detection and Ranging (LiDAR) data of the Upper Naches River Valley and Nile Slide area of interest on September 30th,...

  15. Metatheoriebildung in der dialogischen Konfliktbearbeitung – ein konzeptioneller Vorschlag am Beispiel der Konflikttransformation nach Galtung und des Konfliktmanagements nach Glasl und des Integralen Ansatzes nach Wilber

    Directory of Open Access Journals (Sweden)

    Karim Fathi

    2010-07-01

    really integrated Peace and Conflict Researcher should be familiar with epistemological and heuristic contexts, but also metatheoretical and theoretical contexts as well. Abstract - Deutsch Angesichts immer komplexerer Konflikte in der Friedens- und Konfliktforschung (Friedens- und Konfliktforschung sind Metatheorien von Nöten, die diese unübersichtliche Vielfalt unterschiedlicher Methoden zu integrieren vermögen. Im Rahmen des vorliegenden Papers soll hierzu ein konzeptioneller Vorschlag skizziert werden, indem zwei holistische und bekannte Ansätze der mediativen Konfliktbearbeitung in einem integrativen Kontext diskutiert werden:- Der Konfliktmanagement-Ansatz nach Prof. Dr. Friedrich Glasl (2004.- Die Transcend-Methode nach Prof. Dr. Johan Galtung (2000. Den theoretischen Rahmen, auf den sich die Überlegungen dieser Arbeit stützen, liefert der Integrale Ansatz (IA von Ken Wilber (2001 – eine viel diskutierte philosophische „Theorie von Allem“, die im Rahmen der Friedens- und Konfliktforschung jedoch noch weitgehend unberücksichtigt geblieben ist. Daher ist es im Rahmen der Arbeit von weiterem Interesse den IA auf seinen Mehrwert für eine integrierte Friedens- und Konfliktforschung zu untersuchen.Die Untersuchung verlief wie folgt: 1. Vorstellung der in der Untersuchung berücksichtigten Ansätze: a. Der Konfliktmanagement-Ansatz von Glasl unterscheidet eine Vielzahl von Kategorien und Ansatzmomenten, die ein komplexes Interventionsspektrum ergeben. Sehr wichtig ist hierbei unter anderem die Berücksichtigung von Eskalationsstufen, die eine Unterscheidung zwischen perzeptions- (niedrige Eskalation, gefühls- (mittlere Eskalation und verhaltensorientierten (hohe Eskalation Maßnahmen ermöglichen. b. Die Konflikttransformation nach Galtung zeichnet sich unter anderem durch dreigeteilte Schematisierungen aus, die ein komplexes Verständnis von Gewalt (direkt, kulturell, strukturell, Konflikt (Verhalten, Annahmen, Widerspruch und Frieden (Gewaltlosigkeit

  16. Gonorrhoe bei Erwachsenen und Adoleszenten

    Directory of Open Access Journals (Sweden)

    Bremer, Viviane

    2014-04-01

    Full Text Available According to WHO estimates, Neisseria gonorrhoeae accounted for illion infections in 2008, a number of cases approximately matching those of Chlamydia infections. Gonococcal infections thus represent one of the most common causes of sexually transmitted diseases worldwide, second only to trichomonas vaginalis infections.This guideline aims to improve patient care by optimizing the diagnosis and treatment of infections due to Neisseria gonorrhoeae and to raise awareness among medical professionals of current treatment options.

  17. Characterisation of ribosomal proteins from HeLa and Krebs II mouse ascites tumor cells by different two-dimensional polyacrylamide gel electrophoresis techniques

    DEFF Research Database (Denmark)

    Issinger, O G; Beier, H

    1978-01-01

    Electrophoresis of ribosomal proteins according to Kaltschmidt and Wittmann, 1970a, b (pH 8.6/pH 4.5 urea system) yielded 29 proteins for the small subunits and 35 and 37 proteins for the large subunits of Krebs II ascites and HeLa ribosomes, respectively. Analysis of the proteins according...... to a modified technique by Mets and Bogorad (1974) (pH 4.5/pH 8.6 SDS system) revealed 28 and 29 proteins in the small subunits and 37 and 38 proteins in the large subunits of Krebs II ascites and HeLa ribosomes. The molecular weights of the individual proteins were determined by: 1. "three-dimensional" gel...... using the pH 4.5/pH 8.6 SDS system. The molecular weights Krebs II ascites and HeLa ribosomal proteins are compared with those obtained by other authors for different mammalian species....

  18. Properties of internalization factors contributing to the uptake of extracellular DNA into tumor-initiating stem cells of mouse Krebs-2 cell line.

    Science.gov (United States)

    Dolgova, Evgeniya V; Potter, Ekaterina A; Proskurina, Anastasiya S; Minkevich, Alexandra M; Chernych, Elena R; Ostanin, Alexandr A; Efremov, Yaroslav R; Bayborodin, Sergey I; Nikolin, Valeriy P; Popova, Nelly A; Kolchanov, Nikolay A; Bogachev, Sergey S

    2016-05-25

    Previously, we demonstrated that poorly differentiated cells of various origins, including tumor-initiating stem cells present in the ascites form of mouse cancer cell line Krebs-2, are capable of naturally internalizing both linear double-stranded DNA and circular plasmid DNA. The method of co-incubating Krebs-2 cells with extracellular plasmid DNA (pUC19) or TAMRA-5'-dUTP-labeled polymerase chain reaction (PCR) product was used. It was found that internalized plasmid DNA isolated from Krebs-2 can be transformed into competent Escherichia coli cells. Thus, the internalization processes taking place in the Krebs-2 cell subpopulation have been analyzed and compared, as assayed by E. coli colony formation assay (plasmid DNA) and cytofluorescence (TAMRA-DNA). We showed that extracellular DNA both in the form of plasmid DNA and a PCR product is internalized by the same subpopulation of Krebs-2 cells. We found that the saturation threshold for Krebs-2 ascites cells is 0.5 μg DNA/10(6) cells. Supercoiled plasmid DNA, human high-molecular weight DNA, and 500 bp PCR fragments are internalized into the Krebs-2 tumor-initiating stem cells via distinct, non-competing internalization pathways. Under our experimental conditions, each cell may harbor 340-2600 copies of intact plasmid material, or up to 3.097 ± 0.044×10(6) plasmid copies (intact or not), as detected by quantitative PCR. The internalization dynamics of extracellular DNA, copy number of the plasmids taken up by the cells, and competition between different types of double-stranded DNA upon internalization into tumor-initiating stem cells of mouse ascites Krebs-2 have been comprehensively analyzed. Investigation of the extracellular DNA internalization into tumor-initiating stem cells is an important part of understanding their properties and possible destruction mechanisms. For example, a TAMRA-labeled DNA probe may serve as an instrument to develop a target for the therapy of cancer, aiming at elimination of

  19. Folgebewertung im vorratsvermögen - Fallstudie zur Vorgehensweise nach IFSR und HGB

    DEFF Research Database (Denmark)

    Quick, Reiner; Warming-Rasmussen, Bent

    2013-01-01

    über die wichstigsten Normen zur Folgebeweriung nach IFSR und HGB sowie zu deren Auslegung. Es schliessen sich ein Fallbeispiel und ein Vorschlag zu dessen Lösung an, in dessen Mittelpunkt sinkende Zeitwerte, die Frage des für die Folgebewerunng relevanten Markts und das Zuschreibungsgebot stehen....

  20. Krebs Cycle Intermediates Protective against Oxidative Stress by Modulating the Level of Reactive Oxygen Species in Neuronal HT22 Cells

    Directory of Open Access Journals (Sweden)

    Kenta Sawa

    2017-03-01

    Full Text Available Krebs cycle intermediates (KCIs are reported to function as energy substrates in mitochondria and to exert antioxidants effects on the brain. The present study was designed to identify which KCIs are effective neuroprotective compounds against oxidative stress in neuronal cells. Here we found that pyruvate, oxaloacetate, and α-ketoglutarate, but not lactate, citrate, iso-citrate, succinate, fumarate, or malate, protected HT22 cells against hydrogen peroxide-mediated toxicity. These three intermediates reduced the production of hydrogen peroxide-activated reactive oxygen species, measured in terms of 2′,7′-dichlorofluorescein diacetate fluorescence. In contrast, none of the KCIs—used at 1 mM—protected against cell death induced by high concentrations of glutamate—another type of oxidative stress-induced neuronal cell death. Because these protective KCIs did not have any toxic effects (at least up to 10 mM, they have potential use for therapeutic intervention against chronic neurodegenerative diseases.

  1. Body weight gain after radioiodine therapy of hyperthyroidism; Koerpergewichtsentwicklung nach Radioiodtherapie einer Hyperthyreose

    Energy Technology Data Exchange (ETDEWEB)

    Scheidhauer, K.; Odatzidu, L.; Schicha, H. [Koeln Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Kiencke, P. [Koeln Univ. (DE). Inst. fuer Medizinische Statistik, Informatik und Epidemiologie (IMSIE)

    2002-02-01

    Aim: Analysis and follow up of body weight after radioiodine therapy (RITh) of hyperthyroidism, since excessive weight gain is a common complaint among these patients. Methods: Therapy and body weight related data of 100 consecutive RITh-patients were retrospectively analysed from the time before up to three years after RITh. All patients suffered from hyperthyroidism (Graves' disease or autonomy), but were adjusted to euthyroid levels after RITh. Patients' data were compared to a control group of 48 euthyroid patients out of the same ambulance and during the same time scale. Results: All patients (RITh and controls) gained weight over the time. There was no statistically significant difference in BMI development over three years between RITh-patients and controls (5.5% resp. 4.9% increase). In the first year after RITh, weight gain of the RITh patients was higher indeed, but lower in the follow up, resulting in the same range of weight gain after three years as the controls. Besides that women showed a slightly higher increase of BMI than men, and so did younger patients compared to elder as well as patients with overweight already before RITh. Conclusions: An initially distinct increase of body weight after RITh of hyperthyroidism is mainly a compensation of pretherapeutic weight loss due to hyperthyroidism. Presupposing adequate euthyroid adjustment of thyroid metabolism after therapy, RITh is not responsible for later weight gain and adipositas. (orig.) [German] Ziel: Untersuchung der Entwicklung des Koerpergewichtes nach {sup 131}I-Therapie einer Hyperthyreose, da der Radioiodtherapie (RITh) haeufig eine exzessive posttherapeutische Gewichtszunahme angelastet wird. Methoden: Retrospektiv wurden therapie- und koerpergewichtsbezogene Daten von 100 konsekutiven Patienten vor und bis drei Jahre nach RITh einer Hyperthyreose (Morbus Basedow oder funktionelle Autonomie) erfasst und mit denen einer euthyreoten Kontrollgruppe (n = 48) verglichen. Die

  2. DNA-Methylierung nach abiotischen und biotischen Einflüssen und Expressionsanalyse pathogeninduzierter Gene in Picea abies (L.) Karst.

    OpenAIRE

    Baumann, Ruediger

    2006-01-01

    Basierend auf Beobachtungen über phänotypische Änderungen in Vollgeschwisterfamilien der Fichte,Picea abies, aus unterschiedlichen Kreuzungsumwelten wurde nach der geneti-schen Untersuchung mit EST-Markern eine kapillarelektrophoretische Untersuchung der DNA durchgeführt. Dabei wurden signifikante Unterschiede im Methylcytosin(mC)-Gehalt festgestellt. Messungen der mC-Gehalte nach Hitzeschock zeigten, den Einfluss der Um-weltbedingungen auf die Methylierung der DNA. Untersuchungen zur Dynamik...

  3. Postoperative Verlaufskontrollen beim Ulcus cruris nach Shave-Operation und Hauttransplantation

    OpenAIRE

    Pantelaki, Ioanna

    2016-01-01

    \\(\\bf Hintergrund:\\) Die Arbeit hat das Ziel die Shave-Operation mit Meshgraft-Deckung hinsichtlich der Einheilungsrate und der Schmerzreduktion zu untersuchen. \\(\\bf Methoden:\\) 56 Patienten mit einem Ulcus cruris unterzogen sich dem genannten Eingriff. Vor und 6 Monate nach der Operation wurden die Ulkusgröße, die bakterielle Besiedlung und die Schmerzintensität analysiert. \\(\\bf Ergebnis:\\) Bei 42,86% der Patienten konnte eine Abheilung erreicht werden, wobei die Ergebnisse hoch sign...

  4. Temporary dosal characteristics of processes of Krebs cycle of lungs tissue of rats under prolonged inhalation of uranium dust

    International Nuclear Information System (INIS)

    Bekenova, Zh. M.; Mustafina, R. Kh.; Kazymbet, P. K.

    2010-01-01

    Effect of industrial uranium ore dust (UOD) in extrasmall doses have been studied after prolonged inhalation. It has been established that prolonged inhalation influence of the uranium ore dust (UOD) at the dose equal to 5 threshold limit value (TLV) gradually raised a content of isocitric acid (ICA) - the original product of the Cycle of Tricarbon Acid (NOA). However by the end of the observation already on the 120-th day the peak of increasing ICA started to come down and its indicators exceeded the control level by only 57%. At the same time it has been established that the aqueos licorice root extract facilitates raising a content of ICA which is the product of initial stages in Krebs cycle by 3 times in comparison with the control data and it was by 71% more than under UOD influence. In this case it is the evolution of examined compound ratio, determined as a balance coefficient isocitric acid/malic acid at different periods of UOD effect. It has been identified that at different times of examination its indicators have decreased almost two fold. Also, in the lung tissue of the animals, primed with UOD dose equal to 5 OLV, absolute content of malic acid (MA) practically has not been changing, unless consider the raising of its indicators by 27% and 20% on the 60-th and 120-th days respctively, e.g. in the period of. It has been identified that the licorice root extract has increased concentration indicators of the malic acid in the lung tissue by the average of 4-5%. In this situation particular significance is acquired by dynamics of ratio variation in compounds under investigation determined through a balance coefficient ICA/AA at different periods of UOD effect. It is established that the value of it is lowed by almost 2 times in different terms of observation. Additionally with noticed data in lung tissue activity inhibition of 4-Dehydrogenases in Krebs cycle is revealed. Maximal inhibition is characteristic for Isocitrate- and alphakethoglutarate

  5. Metabolismo del Ejercicio; Propuesta didáctica para la enseñanza-aprendizaje de la glucólisis y el ciclo de Krebs

    OpenAIRE

    Ávila Jiménez, Andrés Alberto

    2012-01-01

    Este trabajo presenta una propuesta didáctica para la enseñanza aprendizaje de la Glucólisis y el Ciclo de Krebs del curso de bioquímica dirigido a estudiantes de primer semestre de la carrera de Cinética Humana y Fisioterapia de la Institución Universitaria Iberoamericana, mediante el diseño de una Unidad Didáctica, abordada desde el estudio de la Glucólisis y el Ciclo de Krebs y sus correlación con la fisiología del deporte y el metabolismo del ejercicio, esta diseñada desde el modelo de re...

  6. Determination of Krebs cycle metabolic carbon exchange in vivo and its use to estimate the individual contributions of gluconeogenesis and glycogenolysis to overall glucose output in man

    International Nuclear Information System (INIS)

    Consoli, A.; Kennedy, F.; Miles, J.; Gerich, J.

    1987-01-01

    Current isotopic approaches underestimate gluconeogenesis in vivo because of Krebs cycle carbon exchange and the inability to measure intramitochondrial precursor specific activity. We therefore applied a new isotopic approach that theoretically overcomes these limitations and permits quantification of Krebs cycle carbon exchange and the individual contributions of gluconeogenesis and glycogenolysis to overall glucose outputex. [6-3H]Glucose was infused to measure overall glucose output; [2-14C]acetate was infused to trace phosphoenolpyruvate gluconeogenesis and to calculate Krebs cycle carbon exchange as proposed by Katz. Plasma [14C]3-OH-butyrate specific activity was used to estimate intramitochondrial acetyl coenzyme A (CoA) specific activity, and finally the ratio between plasma glucose 14C-specific activity and the calculated intracellular phosphoenolpyruvate 14C-specific activity was used to determine the relative contributions of gluconeogenesis and glycogenolysis to overall glucose output. Using this approach, acetyl CoA was found to enter the Krebs cycle at twice (postabsorptive subjects) and three times (2 1/2-d fasted subjects) the rate of pyruvate, respectively. Gluconeogenesis in postabsorptive subjects (3.36 +/- 0.20 mumol/kg per min) accounted for 28 +/- 2% of overall glucose output and increased twofold in subjects fasted for 2 1/2-d (P less than 0.01), accounting for greater than 97% of overall glucose output. Glycogenolysis in postabsorptive subjects averaged 8.96 +/- 0.40 mumol/kg per min and decreased to 0.34 +/- 0.08 mumol/kg per min (P less than 0.01) after a 2 1/2-d fast. Since these results agree well with previously reported values for gluconeogenesis and glycogenolysis based on determinations of splanchnic substrate balance and glycogen content of serial liver biopsies

  7. Effect of outdoor and indoor air pollution on lung function, bronchial hyperresponsiveness and risk of pulmonary disease of adults; Langzeitevaluation von Umwelteinfluessen auf Lungenfunktion, bronchiale Hyperreagibilitaet und Krankheitsrisiko von Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Eltschka, R [Freiburg Univ. (Germany). Zentrum Innere Medizin

    1992-10-01

    The effect of outdoor exposure to SO{sub 2}, NO{sub 2}, particulate pollutants, ozone and pollen on pulmonary function and respiratory discomfort was studied over a period of 1 1/2 yr in 133 no smoking adults at the city of Freiburg. Concentration of indoor and outdoor pollutants were measured. Between January and December 1989 we found in comparison with other large towns low levels of SO{sub 2}, NO{sub 2} and particulate combustion products. The evaluation of individual exposure to air pollutants with lung function measurements shows that participants with essential hyperreactivity demonstrate a significant decrease of the FEV1/IVC - ratio with a threshold value of about 30 {mu}g/m{sup 3} NO{sub 2}. The analyses of the longitudinal study shows a significant correlation between daily peakflow measurements and ozone levels in patients with symptomatic asthma bronchiale and chronic obstructive pulmonary disease. For pollen, SO{sub 2}, NO{sub 2} and anorganic particulate pollutants we did not find any significant effects on peak expiratory flow measurements. (orig./MG) [Deutsch] Der Einfluss von Aussenluftschadstoffen (SO{sub 2}, NO{sub 2}, Staub und Ozon) auf die Lunge wurde in Freiburg in Form einer 1 1/2-jaehrigen Longitudinalstudie bei 133 nicht rauchenden Erwachsenen untersucht. Waehrend des Beobachtungszeitraumes 10/88 - 4/90 erfolgte die Messung der Aussen- und Innenluftschadstoffe. Die Messungen des DW und der LFU zeigen fuer den Zeitraum Januar-Dezember 1989 im Vergleich zu anderen Grossstaedten niedrige Schwefeldioxid-, Stickoxid- und Staubkonzentrationen. Die Querschnittsuntersuchung mit Anamnesefragebogen, Bodyplethysmographie und inhalativem Provokationstest zeigt bei Teilnehmern mit essentieller Hyperreagibilitaet eine signifikante Abnahme des gemessenen und adjustierten Tiffeneau-Index durch NO{sub 2} mit einem Schwellenwert bei 30 {mu}g/m{sup 3}. Die multivariate Analyse der Longitudinalstudie zeigt bei Patienten mit symptomatischem Asthma und

  8. Glucose metabolism via the pentose phosphate pathway, glycolysis and Krebs cycle in an orthotopic mouse model of human brain tumors.

    Science.gov (United States)

    Marin-Valencia, Isaac; Cho, Steve K; Rakheja, Dinesh; Hatanpaa, Kimmo J; Kapur, Payal; Mashimo, Tomoyuki; Jindal, Ashish; Vemireddy, Vamsidhara; Good, Levi B; Raisanen, Jack; Sun, Xiankai; Mickey, Bruce; Choi, Changho; Takahashi, Masaya; Togao, Osamu; Pascual, Juan M; Deberardinis, Ralph J; Maher, Elizabeth A; Malloy, Craig R; Bachoo, Robert M

    2012-10-01

    It has been hypothesized that increased flux through the pentose phosphate pathway (PPP) is required to support the metabolic demands of rapid malignant cell growth. Using orthotopic mouse models of human glioblastoma (GBM) and renal cell carcinoma metastatic to brain, we estimated the activity of the PPP relative to glycolysis by infusing [1,2-(13) C(2) ]glucose. The [3-(13) C]lactate/[2,3-(13) C(2) ]lactate ratio was similar for both the GBM and brain metastasis and their respective surrounding brains (GBM, 0.197 ± 0.011 and 0.195 ± 0.033, respectively (p = 1); metastasis: 0.126 and 0.119 ± 0.033, respectively). This suggests that the rate of glycolysis is significantly greater than the PPP flux in these tumors, and that the PPP flux into the lactate pool is similar in both tumors. Remarkably, (13) C-(13) C coupling was observed in molecules derived from Krebs cycle intermediates in both tumor types, denoting glucose oxidation. In the renal cell carcinoma, in contrast with GBM, (13) C multiplets of γ-aminobutyric acid (GABA) differed from its precursor glutamate, suggesting that GABA did not derive from a common glutamate precursor pool. In addition, the orthotopic renal tumor, the patient's primary renal mass and brain metastasis were all strongly immunopositive for the 67-kDa isoform of glutamate decarboxylase, as were 84% of tumors on a renal cell carcinoma tissue microarray of the same histology, suggesting that GABA synthesis is cell autonomous in at least a subset of renal cell carcinomas. Taken together, these data demonstrate that (13) C-labeled glucose can be used in orthotopic mouse models to study tumor metabolism in vivo and to ascertain new metabolic targets for cancer diagnosis and therapy. Copyright © 2012 John Wiley & Sons, Ltd.

  9. Metabolism of [2-14C]acetate and its use in assessing hepatic Krebs cycle activity and gluconeogenesis

    International Nuclear Information System (INIS)

    Schumann, W.C.; Magnusson, I.; Chandramouli, V.; Kumaran, K.; Wahren, J.; Landau, B.R.

    1991-01-01

    To examine the fate of the carbons of acetate and to evaluate the usefulness of labeled acetate in assessing intrahepatic metabolic processes during gluconeogenesis, [2-14C]acetate, [2-14C]ethanol, and [1-14C]ethanol were infused into normal subjects fasted 60 h and given phenyl acetate. Distributions of 14C in the carbons of blood glucose and glutamate from urinary phenylacetylglutamine were determined. With [2-14C]acetate and [2-14C]ethanol, carbon 1 of glucose had about twice as much 14C as carbon 3. Carbon 2 of glutamate had about twice as much 14C as carbon 1 and one-half to one-third as much as carbon 4. There was only a small amount in carbon 5. These distributions are incompatible with the metabolism of [2-14C]acetate being primarily in liver. Therefore, [2-14C]acetate cannot be used to study Krebs cycle metabolism in liver and in relationship to gluconeogenesis, as has been done. The distributions can be explained by: (a) fixation of 14CO2 from [2-14C]acetate in the formation of the 14C-labeled glucose and glutamate in liver and (b) the formation of 14C-labeled glutamate in a second site, proposed to be muscle. [1,3-14C]Acetone formation from the [2-14C]acetate does not contribute to the distributions, as evidenced by the absence of 14C in carbons 2-4 of glutamate after [1-14C]ethanol administration

  10. Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency.

    Science.gov (United States)

    Richter, Susan; Peitzsch, Mirko; Rapizzi, Elena; Lenders, Jacques W; Qin, Nan; de Cubas, Aguirre A; Schiavi, Francesca; Rao, Jyotsna U; Beuschlein, Felix; Quinkler, Marcus; Timmers, Henri J; Opocher, Giuseppe; Mannelli, Massimo; Pacak, Karel; Robledo, Mercedes; Eisenhofer, Graeme

    2014-10-01

    Mutations of succinate dehydrogenase A/B/C/D genes (SDHx) increase susceptibility to development of pheochromocytomas and paragangliomas (PPGLs), with particularly high rates of malignancy associated with SDHB mutations. We assessed whether altered succinate dehydrogenase product-precursor relationships, manifested by differences in tumor ratios of succinate to fumarate or other metabolites, might aid in identifying and stratifying patients with SDHx mutations. PPGL tumor specimens from 233 patients, including 45 with SDHx mutations, were provided from eight tertiary referral centers for mass spectrometric analyses of Krebs cycle metabolites. Diagnostic performance of the succinate:fumarate ratio for identification of pathogenic SDHx mutations. SDH-deficient PPGLs were characterized by 25-fold higher succinate and 80% lower fumarate, cis-aconitate, and isocitrate tissue levels than PPGLs without SDHx mutations. Receiver-operating characteristic curves for use of ratios of succinate to fumarate or to cis-aconitate and isocitrate to identify SDHx mutations indicated areas under curves of 0.94 to 0.96; an optimal cut-off of 97.7 for the succinate:fumarate ratio provided a diagnostic sensitivity of 93% at a specificity of 97% to identify SDHX-mutated PPGLs. Succinate:fumarate ratios were higher in both SDHB-mutated and metastatic tumors than in those due to SDHD/C mutations or without metastases. Mass spectrometric-based measurements of ratios of succinate:fumarate and other metabolites in PPGLs offer a useful method to identify patients for testing of SDHx mutations, with additional utility to quantitatively assess functionality of mutations and metabolic factors responsible for malignant risk.

  11. Imaging of postarthroscopic complications after knee injuries; Bildgebung postarthroskopischer Komplikationen nach Knieverletzungen

    Energy Technology Data Exchange (ETDEWEB)

    Schueller-Weidekamm, C. [Medizinische Universitaet Wien, Abteilung fuer Neuroradiologie und muskuloskelettale Radiologie, Klinik fuer Radiodiagnostik, Wien (Austria); Skrbensky, G. von [Medizinische Universitaet Wien, Klinik fuer Orthopaedie, Wien (Austria)

    2012-11-15

    The most common joint injuries in professional and recreational sports participants and also in the total population are knee injuries. Arthroscopy is indicated if this modality will improve the patient outcome and potential long-term complications can be avoided. Although uncommon, complications following arthroscopy are mostly evaluated by magnetic resonance imaging (MRI). For planning further therapy strategies following postarthroscopic complications, e.g. if anterior cruciate ligament (ACL) reconstruction is required, digital radiographs and computed tomography (CT) are helpful. This article provides an overview of the different procedures for surgical treatment which are a prerequisite for the analysis of postarthroscopic images. In addition typical complications after treatment of meniscal and chondral injuries as well as after ACL reconstruction are described and typical signs in MRI, radiography and CT are explained in detail. (orig.) [German] Kniegelenkverletzungen sind nicht nur bei Profisportlern, sondern auch in der Gesamtbevoelkerung die haeufigsten Gelenkverletzungen. Die Indikation zur arthroskopischen Operation wird gestellt, wenn im Vergleich zur konservativen Therapie ein besseres Ergebnis postarthroskopisch zu erwarten ist und potenzielle Spaetkomplikationen verhindert werden koennten. Die selten aber dennoch auftretenden postarthroskopischen Komplikationen werden zumeist mit der Magnetresonanztomographie (MRT) abgeklaert. Zur weiteren Therapieplanung nach Komplikationen, z. B. wenn eine Kreuzbandrevision notwendig ist, sind die digitale Projektionsradiographie und die Computertomographie (CT) hilfreich. Dieser Artikel bietet eine kurze Uebersicht ueber die unterschiedlichen Operationstechniken, die eine Voraussetzung fuer das Verstaendnis der bildgebenden postoperativen Veraenderungen sind. Weiter wird auf die haeufigsten Komplikationen nach Meniskus- und Knorpeloperationen sowie nach vorderer Kreuzbandrekonstruktion und den damit

  12. Das Alter ist der wichtigste Risikofaktor der postoperativen erektilen Dysfunktion nach radikaler nerverhaltender Prostatektomie

    Directory of Open Access Journals (Sweden)

    Gruschka M

    2009-01-01

    Full Text Available Die radikale Prostatektomie ohne Nerverhalt geht mit Impotenz einher. Bei nerverhaltendem Vorgehen kann das Risiko der erektilen Dysfunktion gesenkt, aber nicht ausgeschlossen werden. Die präoperative Beratung der Patienten erfordert bei nerverhaltender Prostatektomie die Kenntnis der Faktoren, die Einfluss auf die postoperative Potenz haben. Patienten & Methoden: 110 Patienten antworteten 24 Monate nach radikaler perinealer nerverhaltender Prostatektomie auf einen per Post übermittelten Fragebogen. Die Patienten wurden, entsprechend dem Erection Hardness Score, nach der Rigidität ihrer Erektionen befragt. Überwiegend erfolgte der Nerverhalt unilateral (104/110. Verschiedene potenzielle Risikofaktoren (Alter, Qualität der präoperativen Erektion, Serum-PSA, Gleason-Score, Tumorvolumen, Prostatavolumen, adjuvante Strahlentherapie, ASA-Score, Chronic Disease Score [CDS], arterielle Hypertonie, Hypercholesterinämie, Diabetes mellitus, KHK, Nikotinkonsum wurden univariat mit der postoperativ erzielten Potenz korreliert. Multivariat wurden dann jene Parameter untersucht, die in der univariaten Analyse einen signifikanten (p ≤ 0,05 oder einen tendenziellen Zusammenhang (p ≤ 0,2 mit der postoperativen erektilen Funktion aufwiesen. Ergebnisse:Das Alter (p 0,001 und der ASAScore (p = 0,018 waren in der univariaten Analyse negative Prädiktoren der postoperativen Potenz. In der multivariaten Analyse war lediglich das Alter (p = 0,028 von signifikanter Bedeutung. Mit jedem Lebensjahr der Männer steigt das Risiko einer um eine Stufe im EHS schlechteren Erektion um das 1,128-Fache an. Bei einem Altersunterschied von 10 Jahren ist das Risiko eines postoperativ schlechteren Erektionsvermögens um den Faktor 3,334 erhöht, bei einem um 20 Jahre höheren Alter beträgt dieser Faktor 11,121. Diskussion & Praxisrelevanz: Das Lebensalter der Patienten wurde im Einklang mit der Literatur als signifikanter Faktor für die postoperative Potenz identifiziert

  13. ASS-induzierte Asthmaanfälle nach ASS-Desaktivierung - Fallbericht einer seltenen Komplikation

    OpenAIRE

    Doktorowski, S; Creutz, P; Förster-Ruhrmann, U; Olze, H

    2015-01-01

    Einleitung: Patienten mit einer nasalen Polyposis (NP), einem Asthma und einer ASS-Intoleranz sind häufig durch schwere Krankheitsverläufe gekennzeichnet. Die ASS-Desaktivierung ist eine Therapieoption mit günstigen Effekten auf rhinitische und pulmonale Beschwerden.Methoden: Vorstellung eines ungewöhnlichen Verlaufs eines Patienten nach ASS-Desaktivierung. Ergebnisse: Ein männlicher 34-jähriger Patient mit einer ASS-Trias (NP-Grad 2., FEV-1 94,7%, Ø Peakflow 470 l/Min) erhielt stationär p...

  14. Scintigraphic diagnosis of silent aspiration following double-sided lung transplantation; Szintigraphischer Nachweis einer stillen Aspiration nach beidseitiger Lungentransplantation

    Energy Technology Data Exchange (ETDEWEB)

    Toenshoff, G. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Stock, U. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Bohuslavizki, K.H. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Brenner, W. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin; Costard-Jaeckle, A. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Cremer, J. [Kiel Univ. (Germany). Klinik fuer Herz- und Gefaesschirurgie; Clausen, M. [Kiel Univ. (Germany). Klinik fuer Nuklearmedizin

    1996-08-01

    We present a case of a 25 year old patient who underwent double-sided lung transplantation and suffered from recurrent pneumonia. Silent aspiration was suspected clinically. Aspiration was proved by scintigraphy enabling to discriminate between direct oro-pulmonal aspiration and aspiration after gastro-esophageal reflux. (orig.) [Deutsch] Vorgestellt wird der Fall einer 25jaehrigen Patientin nach beidseitiger Lungentransplantation und rezidivierenden Pneumonien. Klinisch bestand der Verdacht auf eine stille Aspiration. Szintigraphisch gelang sowohl der Aspirationsnachweis als auch eine Differenzierung hinsichtlich der Genese: Direkte oro-pulmonale Aspiration versus Aspiration nach gastrooesophagealem Reflux. (orig.)

  15. Investigations regarding the anthropic impact on the Krebs cycle dehydrogenases system on certain wood-species in mining areas, Suceava county

    Directory of Open Access Journals (Sweden)

    Marius Viorel Oniciuc

    2013-03-01

    Full Text Available The Krebs cycle, a second stage of cellular respiration that occurs in the mitochondrion of the leafcell and consist in a multistep processes plays a central role in catabolism of organic fuel molecules. The miningextraction technologies for both underground and surface, the preparation of copper ore and barite applied in Tarnia,respectively to the sulphur in Calimani Mountain and the excess of these elements in natural environment may causemalfunction of ecosystem. The dehydrogenases of Krebs cycle can give information on the type and the duration of theeffects of pollutants on the metabolic activity in leaves, to subsequent area pollution, therefore, the aim of the presentstudy has been to determine these effects on this enzymatic system activity. For this reason, the isocitrate dehydrogenase,the -ketoglutate dehydrogenase, the succinate ehydrogenase and the malate dehydrogenase activity was determined using the spectrophotometric method with triphenyl-tetrazolium and the analysis of experimental results shows the differences from one sample to another sample of closely related species specificity, but also the effect of environmentalfactors.

  16. Nonlinear drift-diffusion model of gating in K and nACh ion channels

    Energy Technology Data Exchange (ETDEWEB)

    Vaccaro, S.R. [Department of Physics, University of Adelaide, Adelaide, South Australia 5005 (Australia)], E-mail: svaccaro@physics.adelaide.edu.au

    2007-09-03

    The configuration of a sensor regulates the transition between the closed and open states of both voltage and ligand gated channels. The closed state dwell-time distribution f{sub c}(t) derived from a Fokker-Planck equation with a nonlinear diffusion coefficient is in good agreement with experimental data and can account for the power law approximation to f{sub c}(t) for a delayed rectifier K channel and a nicotinic acetylcholine (nACh) ion channel. The solution of a master equation which approximates the Fokker-Planck equation provides a better description of the small time behaviour of the dwell-time distribution and can account for the empirical rate-amplitude correlation for these ion channels.

  17. Präoperative Vorhersge der Rezidivrate des klinisch lokalisierten Prostatakarzinoms nach einer radikalen Prostatektomie

    Directory of Open Access Journals (Sweden)

    Graefen M

    1999-01-01

    Full Text Available Die radikale Prostatektomie scheint die zur Zeit effektivste Therapie des klinisch lokalisierten Prostatakarzinoms zu sein. Dennoch liegt die Rezidivrate bei bis zu 40 % der operierten Patienten. Mit dieser Arbeit wurde anhand präoperativer Befunde ein Algorithmus entwickelt, mit welchem die Prognose des klinisch lokalisierten Prostatakarzinoms bereits vor einer operativen Therapie abgeschätzt werden kann. Hierzu wurden multiple präoperative Befunde, welche bei der Diagnose des Prostatakarzinoms erhoben werden, bezüglich ihres Einflusses auf einen PSA-Progress nach radikaler Prostatektomie geprüft. Dies erfolgte mittels einer univariaten Kaplan-Meier Analyse sowie einer multivariaten Statistik (Cox-Regression und CART-Analyse. Schwerpunkt bildete hierbei die Einbeziehung der Ergebnisse der systematischen Sextanten-Biopsie der Prostata. Alle präoperativen Befunde haben in der univariaten Kaplan-Meier Analyse einen signifikanten Einfluß auf ein PSA-Rezidiv. In der Cox-Regression hatte der Anteil an niedrigdifferenziertem Prostatakarzinom den größten Einfluß auf das Auftreten eines Tumorprogresses, gefolgt von der Anzahl der positiven Stanzen in der Biopsie und dem präoperativen PSA-Wert; alle anderen Parameter hatten keinen unabhängig signifikanten Einfluß auf den Tumorprogress. Mittels der zusätzlich durchgeführten CART Analyse konnten verschiedene Risikogruppen definiert werden, deren Rezidivrisiko bei 3 % für Patienten mit geringem Rezidivrisiko sowie 80 % für solche mit einem hohen Rezidivrisiko 2 Jahre nach der Operation betrug. Der niedrigdifferenzierte Tumoranteil hat somit den größten Einfluß auf die Prognose eines klinisch lokalisierten Prostatakarzinoms. Anhand der präsentierten CART-Analysen wurden einfach anwendbare Entscheidungsbäume entwickelt, mit denen eine Abschätzung des Therapieerfolges des klinisch lokalisierten Prostatakarzinoms bereits vor einer Operation möglich ist.

  18. CARACTERIZAÇÃO DA ATIVIDADE PRÓ-OXIDANTE DE DIFERENTES AGENTES E ESTUDO DO POTENCIAL ANTIOXIDANTE DE INTERMEDIÁRIOS DO CICLO DE KREBS SOBRE ALTERAÇÕES OXIDATIVAS INDUZIDAS IN VITRO

    OpenAIRE

    Robson Luiz Puntel

    2008-01-01

    Dados prévios da literatura têm mostrado que alguns intermediários do ciclo de Krebs podem agir como antioxidantes em diversos modelos, tanto in vitro, quanto in vivo. Porém, o(s) mecanismo(s) através dos qual(is) esses intermediários exercem suas atividades antioxidantes não são completamente entendidas. Considerando a escassez de dados na literatura a respeito do efeito dos intermediários do ciclo de Krebs durante situações de estresse oxidativo, o presente trabalho teve por objetivo determ...

  19. Ciclo de Krebs como fator limitante na utilização de ácidos graxos durante o exercício aeróbico

    OpenAIRE

    Curi, Rui; Lagranha, Cláudia J.; G. Jr, Jair Rodrigues; Pithon-Curi, Tania Cristina; Lancha Jr, Antonio Herbert; Pellegrinotti, Ídico L.; Procopio, Joaquim

    2003-01-01

    Os ácidos graxos (AG) representam uma fonte importante de energia durante exercícios de intensidade leve ou moderada, e principalmente naqueles de duração prolongada. A utilização dos AG pelos músculos esqueléticos depende de passos importantes como a mobilização, transporte via corrente sangüínea, passagem pelas membranas plasmática e mitocôndrial, beta-oxidação e, finalmente, a oxidação no ciclo de Krebs e atividade da cadeia respiratória. O exercício agudo e o treinamento induzem adaptaçõe...

  20. Das Répertoire International des Sources Musicales (RISM nach Fünfzig Jahren

    Directory of Open Access Journals (Sweden)

    Heckmann, Harald

    2001-12-01

    Full Text Available In 1952, a Commission Mixte formed by members of the International Musicological Society (IMS and the International Association of Music Libraries (lAML constituted in Paris the Répertoire International des Sources Musicales (RISM. In 1971, the first two volumes appeared - the Écrits imprimés concernant la musique edited by François Lesure. In 1960, a central editorial office (Zentralredaktion was founded in Kassel for the Series of the Einzeldrucke vor 1800/Single Prints before 1800. Consisting of 13 volumes, this is now complete with the exception of an index. Since moving to Frankfurt am Main in 1987, the Zentralredaktion has concentrated its work on the Handschriften nach 1600/Manuscripts after 1600. Because of its scope, this project presented RISM with an enormous challenge and, therefore, digitalization was a very early priority. In 1995, the first CD-ROM with the RISM manuscript database appeared followed each year by a cumulative edition; the sixth CD appeared at the end of 2000 containing about 350,000 entries from 575 libraries in 31 countries. Looking at what has been achieved in the last 50 years and taking into account the Series of special catalogs, now expanded to 29 printed volumes, the result deserves respect. There are, however, gaps. These include the fact that in some countries with an especially rich tradition, sources not yet accessible will have to be integrated into the RISM catalog. Spain is such a country and F. Gonzalez Valle has rendered great service in making these sources accessible. His pupils and successors are called upon to mobilize all forces so that within the international RISM community Spain takes up the place appropriate to its past and present rich musical culture.[de] 1952 konstituierte eine Commission Mixte aus Mitgliedern der Internationalen Gesellschaft fur Musikwissenschaft (IGMW und der Internationalen Vereinigung der Musikbibliotheken (IVMB in Paris das Répertoire International des Sources

  1. Morphologische Veränderung des Beckenbodens und klinisches Outcome nach Resektionsrektopexie bei Beckenbodeninsuffizienz : Eine explorative, deskriptive Studie anhand der dynamischen Beckenboden-MRT

    OpenAIRE

    Busse, Anika

    2013-01-01

    Der Beckenboden und insbesondere die Beckenbodeninsuffizienz mit ihren Folgeerkrankungen wie anale Inkontinenz und Obstipationen sind nach wie vor ein Tabuthema. Aufgrund der steigenden Prävalenz, der damit verbundenen steigenden Kosten für das Gesundheitssystem und aufgrund der deutlichen Beeinflussung der Lebensqualität ist es wichtig effektive diagnostische Möglichkeiten und Therapien zu besitzen. Ziel dieser vorliegenden Studie sollte es somit sein das Outcome nach Resektionsrektopexie be...

  2. Abscesses after appendectomy due to intraoperative loss of fecaliths; Abszesse nach Appendektomie durch intraoperativ verlorene Appendicolithen

    Energy Technology Data Exchange (ETDEWEB)

    Hoermann, M.; Kreuzer, S. [Universitaetsklinik fuer Radiodiagnostik, Vienna (Austria). Abt. chirurgische Faecher; Sacher, P. [UniversitaetsSpital Zuerich (Switzerland). Abt. Kinderchirurgie; Eich, G.F. [UniversitaetsSpital Zuerich (Switzerland). Inst. fuer Diagnostische Radiologie

    2001-08-01

    Objective: Fecaliths appear to predispose a patient to acute appendicitis, abscess formation, and perforation. The number of preoperative radiological evaluations is increasing, although children with suspected perforation still undergo surgery immediately. We report and discuss imaging findings and implications in children with acute appendicitis and fecalithis. Methods: Four children (3 girls, 1 boy; mean age 9 years) underwent surgery for acute appendicitis. Three children underwent sonography and plain radiography before surgery, 1 child was operated without radiological evaluation. After readmission, all 4 children underwent sonography and plain radiography before surgery. Results: In 3 patients a fecalith was diagnosed initially. After uneventful recovery all 4 patients had acute abdominal pain and readmission was necessary. In all 4 patients the escaped fecalith was demonstrated with sonography and plain radiography confirmed surgically. Conclusion: Discussion about the role of imaging in acute appendicitis has concentrated on the diagnostic yield of cross-section techniques. The importance of demonstrating a fecalith, prompting a more thorough intraoperative search has found little attention. The radiologist should also detect and localize a fecalith and should be aware of retained fecaliths as a cause of abscess formation after appendectomy. (orig.) [German] Ziel: Faekolithen praedisponieren Kinder zu akuter Appendizitis und fuehren vermehrt zu Perforation und Abszessen. Wir berichten und diskutieren die Bedeutung der Bildgebung bei Kindern mit Faekolithen und perforierter akuter Appendizitis. Methoden: 4 Kinder (drei Maedchen, ein Junge, Altersmeridian 9 Jahre) wurden wegen perforierter akuter Appendizitis operiert. Drei Kinder erhielten praeoperativ eine Ultraschalluntersuchung und ein Abdomen-Uebersichtsbild. Nach Neuaufnahme wurden nun bei allen Kindern eine Ultraschalluntersuchung und ein Abdomen-Uebersichtsbild angefertigt und neuerlich operiert

  3. Imaging before and after uterine artery embolization; Bildgebende Diagnostik vor und nach Uterusmyomembolisation

    Energy Technology Data Exchange (ETDEWEB)

    Kroencke, T.J. [Charite - Universitaetsmedizin Berlin, Radiologische Klinik, Campus Virchow-Klinikum, Berlin (Germany)

    2008-07-15

    Percutaneous catheter-based embolization treatment of symptomatic uterine fibroids has evolved into the most widely used alternative therapeutic approach to surgical treatment worldwide. Uterine artery embolization (UAE) induces infarction of leiomyomas, resulting in ischemic necrosis, hyaline degeneration, and size reduction with resolution of associated symptoms. Published experience suggests that UAE is an effective and reliable option for treating uterine fibroids with high patient satisfaction. Magnetic resonance imaging (MRI) is superior to ultrasonography for determining the site, size and number of fibroids, which is important for establishing the indication for UAE. Other potential advantages of MRI include the option of performing MR angiography (MRA) and obtaining contrast-enhanced images for monitoring the outcome of UAE and assessing possible complications after UAE. (orig.) [German] Die perkutane kathetergestuetzte Uterusmyomembolisation ist inzwischen weltweit die am meisten verbreitete Alternative zur operativen Behandlung des symptomatischen Uterus myomatosus. Der durch Embolisation der Aa. uterinae (Syn. Uterusarterienembolisation, UAE) bewirkte 'Myominfarkt' fuehrt zu ischaemischer Nekrose, hyalinem Umbau und Groessenreduktion der Myome unter Rueckbildung myomassoziierter Beschwerden. Die bisher publizierten Erfahrungen zeigen, dass es sich bei der Embolisation um eine effektive und sichere Methode mit hoher Patientinnenzufriedenheit handelt. Die Magnetresonanztomographie (MRT) ist dem Ultraschall in der fuer die Indikationsstellung wichtigen Beurteilung von Lage, Groesse und Zahl der Myomknoten ueberlegen. Weitere moegliche Vorteile ergeben sich durch den Einsatz der MR-Angiographie (MRA) sowie kontrastmittelunterstuetzter Aufnahmen zur Erfolgskontrolle und Abklaerung von Komplikationen nach Embolisation. (orig.)

  4. Endovascular brachytherapy to prevent restenosis after angioplasty; Endovaskulaere Brachytherapie in der Restenoseprophylaxe nach Angioplastie und Stentimplantation: Eine Uebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Wohlgemuth, W.A.; Bohndorf, K. [Klinikum Augsburg (Germany). Klinik fuer Diagnostische Radiologie und Neuroradiologie

    2003-02-01

    Endovascular radiotherapy is the first effective prophylaxis of restenosis after percutaneous transluminal angioplasty (PTA) and stenting. The FDA recently approved two devices for the delivery of intracoronary radiation following coronary artery stenting. Published multicenter, double-blind, randomized trials of intracoronary radiation therapy report good results for preventing in-stent restenosis, while the data for the peripheral circulation are still inconclusive. Beta-emitters are easier applicable and probably also safer, whereas gamma-emitters have been more extensively evaluated clinically so far. Primary indication for endovascular brachytherapy are patients at high risk for restenosis, such as previous restenoses, in-stent hyperplasia, long stented segment, long PTA lesion, narrow residual vascular lumen and diabetes. Data from coronary circulation suggest a safety margin of at least 4 to 10 mm at both ends of the angioplastic segment to avoid edge restenosis. To prevent late thrombosis of the treated coronary segment, antiplatelet therapy with clopidogrel and aspirin are recommended for at least 6 months after PTA and for 12 months after a newly implanted stent. An established medication regimen after radiotherapy of peripheral arteries is still lacking. (orig.) [German] Die endovaskulaere Radiotherapie stellt das erste erfolgreiche Therapiekonzept in der Restenoseprophylaxe nach PTA und Stentimplantation dar. Am 3.11.2000 hat die amerikanische Food and Drug Administration erstmalig zwei Brachytherapiegeraete zur Restenoseprophylaxe nach Koronararterien-Stenting zugelassen. Grosse multizentrische, kontrollierte Studien wurden fuer das koronare Stromgebiet mit positiven Ergebnissen publiziert, die Datenlage im peripheren Stromgebiet ist noch ungenuegend. Beta-Strahler bieten Vorteile in der Anwendung, moeglicherweise auch in der Sicherheit, Gamma-Strahler dagegen sind besser klinisch evaluiert. Die primaere Indikation zur endovaskulaeren Brachytherapie

  5. Serum aminotransferases in nonalcoholic fatty liver disease are a signature of liver metabolic perturbations at the amino acid and Krebs cycle level.

    Science.gov (United States)

    Sookoian, Silvia; Castaño, Gustavo O; Scian, Romina; Fernández Gianotti, Tomas; Dopazo, Hernán; Rohr, Cristian; Gaj, Graciela; San Martino, Julio; Sevic, Ina; Flichman, Diego; Pirola, Carlos J

    2016-02-01

    Extensive epidemiologic studies have shown that cardiovascular disease and the metabolic syndrome (MetS) are associated with serum concentrations of liver enzymes; however, fundamental characteristics of this relation are currently unknown. We aimed to explore the role of liver aminotransferases in nonalcoholic fatty liver disease (NAFLD) and MetS. Liver gene- and protein-expression changes of aminotransferases, including their corresponding isoforms, were evaluated in a case-control study of patients with NAFLD (n = 42), which was proven through a biopsy (control subjects: n = 10). We also carried out a serum targeted metabolite profiling to the glycolysis, gluconeogenesis, and Krebs cycle (n = 48) and an exploration by the next-generation sequencing of aminotransferase genes (n = 96). An in vitro study to provide a biological explanation of changes in the transcriptional level and enzymatic activity of aminotransferases was included. Fatty liver was associated with a deregulated liver expression of aminotransferases, which was unrelated to the disease severity. Metabolite profiling showed that serum aminotransferase concentrations are a signature of liver metabolic perturbations, particularly at the amino acid metabolism and Krebs cycle level. A significant and positive association between systolic hypertension and liver expression levels of glutamic-oxaloacetic transaminase 2 (GOT2) messenger RNA (Spearman R = 0.42, P = 0.03) was observed. The rs6993 located in the 3' untranslated region of the GOT2 locus was significantly associated with features of the MetS, including arterial hypertension [P = 0.028; OR: 2.285 (95% CI: 1.024, 5.09); adjusted by NAFLD severity] and plasma lipid concentrations. In the context of an abnormal hepatic triglyceride accumulation, circulating aminotransferases rise as a consequence of the need for increased reactions of transamination to cope with the liver metabolic derangement that is associated with greater gluconeogenesis and

  6. Avascular bone necrosis: MR imaging findings before and after core decompression; MR-Tomographie avaskulaerer Knochennekrosen: Primaerbefunde und Verlaufsbeobachtungen nach Markraumdekompression

    Energy Technology Data Exchange (ETDEWEB)

    Adam, G [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Keulers, P [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Forst, J [Technische Hochschule Aachen (Germany). Klinik fuer Orthopaedie; Neuerburg, J [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Kilbinger, M [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Guenther, R W [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik

    1995-10-01

    17 patients with avascular epiphyseal necrosis were examined by MRI using T{sub 1}-weighted spin echo sequences before and after gadopentetate dimeglumine application, T{sub 2}-weighted spin echo sequences and in some patients with fat-saturated 2D gradient echo sequences up to 22 months after core decompression. All patients but one recovered from symptoms after core decompression. Although the signal morphology of the necrotic area remained unchanged in the majority of the cases, a decrease of the joint effusion was observed as well as an ongoing signal increase after gadopentetate dimeglumine application. The last examinations displayed similar signal characteristics as on the preoperative scans; however, a reduction of the necrotic zone became evident. (orig./MG) [Deutsch] 17 Patienten mit avaskulaerer Epiphysennekrose wurden mit T{sub 1}-gewichteten Spin-Echo-Sequenzen vor und nach Gadolinium-DTPA-Gabe, T{sub 2}-gewichteten Spin-Echo-Sequenzen und teilweise mit fettsupprimierten 2-D-Gradienten-Echo-Sequenzen bis zu 22 Monate nach Markraumdekompression untersucht. Mit einer Ausnahme waren alle Patienten nach dem Eingriff beschwerdefrei. Obwohl sich die Signalmorphologie zunaechst nicht oder wenig aenderte, konnte eine Abnahme des begleitenden Gelenkergusses bei weiterhin nachweisbarem Signalanstieg im Nekroseareal nach Kontrastmittelgabe beobachtet werden. Bei den letzten Untersuchungen nach Dekompression (bis zu 22 Monate) konnten zum Teil noch aehnliche Signalveraenderungen wie bei der Erstuntersuchung, jedoch keine Verkleinerung des Nekroseareals nachgewiesen werden. (orig./MG)

  7. MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

    Directory of Open Access Journals (Sweden)

    Elena Favaro

    2010-04-01

    Full Text Available Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1 and a microRNA, hsa-miR-210 (miR-210 which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial iron sulfur scaffold protein ISCU, required for assembly of iron-sulfur clusters, cofactors for key enzymes involved in the Krebs cycle, electron transport, and iron metabolism. Down regulation of ISCU was the major cause of induction of reactive oxygen species (ROS in hypoxia. ISCU suppression reduced mitochondrial complex 1 activity and aconitase activity, caused a shift to glycolysis in normoxia and enhanced cell survival. Cancers with low ISCU had a worse prognosis.Induction of these major hallmarks of cancer show that a single microRNA, miR-210, mediates a new mechanism of adaptation to hypoxia, by regulating mitochondrial function via iron-sulfur cluster metabolism and free radical generation.

  8. STUDIES ON THE DYNAMICS OF DEHYDROGENASES KREBS CYCLE ACTIVITY AT MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS GROWN ON MEDIA WITH DIFFERENT CARBOHYDRATES

    Directory of Open Access Journals (Sweden)

    Elena Ciornea

    2010-09-01

    Full Text Available As ubiquitous organisms, fungi grow on a large number of organic substrate, alive or dead, confronting therefore with a wide variety of carbohydrates and various physical factors, and their versatility to adapt and be able to use a large number of these compounds could provide them the chance to survive. Given that, these fungi have a rich enzyme equipment that allows them to operate on different metabolic pathways, this study aims to monitor the dynamics activity of some Krebs cycle dehydrogenases in Monilinia laxa (Aderh & Ruhl. Honey species parasitic on various species of plum trees. To this end, the fungus was cultivated in vitro on media enriched with different carbohydrates and the isocitrate dehydrogenase, �-cetoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activity in the fungus mycelium was followed, at 7, respectively, 14 days after the inoculation of the culture medium and determined using the spectrophotometric Sîsoev and Krasna method (Cojocaru, D.C., 2009. Data revealed obvious differences depending on the type of carbohydrate introduced into the medium and the age of the culture mycelia.

  9. STUDIES ON THE DYNAMICS OF DEHYDROGENASES KREBS CYCLE ACTIVITY AT MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS GROWN ON MEDIA WITH DIFFERENT CARBOHYDRATES

    Directory of Open Access Journals (Sweden)

    Elena Ciornea

    2011-11-01

    Full Text Available As ubiquitous organisms, fungi grow on a large number of organic substrate, alive or dead, confronting therefore with a wide variety of carbohydrates and various physical factors, and their versatility to adapt and be able to use a large number of these compounds could provide them the chance to survive. Given that, these fungi have a rich enzyme equipment that allows them to operate on different metabolic pathways, this study aims to monitor the dynamics activity of some Krebs cycle dehydrogenases in Monilinia laxa (Aderh & Ruhl. Honey species parasitic on various species of plum trees. To this end, the fungus was cultivated in vitro on media enriched with different carbohydrates and the isocitrate dehydrogenase, �-cetoglutarate dehydrogenase, succinate dehydrogenase and malate dehydrogenase activity in the fungus mycelium was followed, at 7, respectively, 14 days after the inoculation of the culture medium and determined using the spectrophotometric Sîsoev and Krasna method (Cojocaru, D.C., 2009. Data revealed obvious differences depending on the type of carbohydrate introduced into the medium and the age of the culture mycelia.

  10. Metabolism of γ-hydroxyl-[1-14C] butyrate by rat brain: relationship to the Krebs cycle and metabolic compartmentation of amino acids

    International Nuclear Information System (INIS)

    Doherty, J.D.; Roth, R.H.

    1978-01-01

    Ninhydrin decarboxylation experiments were carried out on the labelled amino acids produced following intraventricular injection of either γ-hydroxy-[1- 14 C] butyric acid (GHB) or [1- 14 C] succinate. The loss of isotope (as 14 CO 2 ) was similar for both substances. The [1- 14 C] GHB metabolites lost 75% of the label and the [1- 14 C] succinate metabolites lost 68%. This observation gives support to the hypothesis that the rat brain has the enzymatic capacity to metabolize [1- 14 C] GHB to succinate and to amino acids that have the isotope in the carboxylic acid group adjacent to the α-amino group. These results also indicate that the label from [1- 14 C] GHB does not enter the Krebs cycle as acetate. The specific activity ratio of radio-labelled glutamine to glutamic acid was determined in order to evaluate which of the two major metabolic compartments prefentially metabolize GHB. It was found that for [1- 14 C] GHB the ratio was 4.20 +- 0.18 (S.E. for n = 7) and for [1- 14 C] succinate the ratio was 7.71 (average of two trials, 7.74 and 7.69). These results suggest that the compartment thought to be associated with glial cells and synaptosomal structures is largely responsible for the metabolism of GHB. Metabolism as it might relate to the neuropharmacological action of GHB is discussed. (author)

  11. A review of endocrine late effects in children after brain tumor therapy; Endokrinologische Funktionsstoerungen nach Hirntumortherapie im Kindesalter

    Energy Technology Data Exchange (ETDEWEB)

    Marx, M.; Langer, T.; Beck, J.D.; Doerr, H.G. [Erlangen-Nuernberg Univ., Erlangen (Germany). Kinderklinik mit Poliklinik

    1999-07-01

    : In der Regel kommt es als erstes und am haeufigsten zu Stoerungen der Wachstumshormonsekretion. Stoerungen der spontanen Wachstumshormonsektretion wurden bereits nach konventionell fraktionierter Schaedelbestrahlung mit 18 Gy beobachtet. Mit einiger Latenz koennen auch Stoerungen der anderen hypothalamo-hypophysaeren Achsen bis hin zum Panhypopituitarismus auftreten. Die Pubertaet kann verfrueht oder verspaetet beginnen oder ganz ausbleiben. Insbesondere bei Maedchen kommt es nach Hirntumortherapie gehaeuft zur fruehen und im Ablauf beschleunigten Pubertaetsentwicklung, die durch eine akzelerierte Knochenreifung zu einer weiteren Verminderung der Endgroesse fuehrt. Hypothalamo-hypophysaer bedingte Stoerungen der Schilddruesenfunktion und der Nebennierenrindenfunktion sind seltener und werden in der Regel erst nach hypothalamo-hypophysaeren Strahlendosen von ueber 40 Gy beobachtet. Schlussfolgerung: Ueberlebende eines Hinrtumors im Kindesalter muessen als Langzeitueberlebende betrachtet werden, bei denen bereits kurz nach Ende der Tumortherapie die ersten der therapiebedingten Spaetfolgen auftreten. Um fuer den individuellen Patienten eine maximale Lebensqualitaet zu erreichen, ist eine langfristige Betreuung mit enger Kooperation der verschiedenen beteiligten Fachdisziplinen unabdingbar. (orig.)

  12. Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

    Directory of Open Access Journals (Sweden)

    Elena V. Tchetina

    2016-01-01

    Full Text Available This study reports the effects of the iron chelator deferoxamine (DFO on collagen cleavage, inflammation, and chondrocyte hypertrophy in relation to energy metabolism-related gene expression in osteoarthritic (OA articular cartilage. Full-depth explants of human OA knee articular cartilage from arthroplasty were cultured with exogenous DFO (1–50 μM. Type II collagen cleavage and phospho-adenosine monophosphate-activated protein kinase (pAMPK concentrations were measured using ELISAs. Gene expression studies employed real-time PCR and included AMPK analyses in PBMCs. In OA explants collagen cleavage was frequently downregulated by 10–50 μM DFO. PCR analysis of 7 OA patient cartilages revealed that 10 μM DFO suppressed expression of MMP-1, MMP-13, IL-1β, and TNFα and a marker of chondrocyte hypertrophy, COL10A1. No changes were observed in the expression of glycolysis-related genes. In contrast, expressions of genes associated with the mitochondrial Krebs cycle (TCA, AMPK, HIF1α, and COL2A1 were upregulated. AMPK gene expression was reduced in OA cartilage and increased in PBMCs from the same patients compared to healthy controls. Our studies demonstrate that DFO is capable of suppressing excessive collagenase-mediated type II collagen cleavage in OA cartilage and reversing phenotypic changes. The concomitant upregulation of proanabolic TCA-related gene expressions points to a potential for availability of energy generating substrates required for matrix repair by end-stage OA chondrocytes. This might normally be prevented by high whole-body energy requirements indicated by elevated AMPK expression in PBMCs of OA patients.

  13. Aktuelle Technik der Bruststraffung beim Mann nach Gewichtsverlust [Modern technique in male breast contouring after weight loss

    Directory of Open Access Journals (Sweden)

    Stoff, Alexander

    2013-08-01

    Full Text Available [english] The morbid adiposity and its medical consequences demonstrates a growing problem of our current prosperous society. Due to a significant improvement of bariatric techniques and a reduplication of adipose patients during the 20 century, the number of patients, who present to plastic surgeons with a new degree of suffering, has been growing steadily. Initially, the female patients were in the majority, which has been more balanced nowadays.The male breast is a body region that primarily symbolizes masculinity and strenght. In male patients after massive weight loss, this body region remains as an extremly deflated breast envelope without any sign of possible retraction. The plastic surgeon may choose from different single or combinated ltechniques, which are indicated depending on the local and adjacent tissue characteristics.We are presenting our modified technique of male breast reshaping, referring to the technique of Aly, except for a NAC transposition on a central pedicle. The central pedicle is hereby preserved from resection after tremendous liposuction. This central pedicle technique allows a safe and uncomplicated NAC transposition with significant advantages compared to free NAC-Transposition techniques in terms of aesthetical and functional outcome. [german] Die morbide Adipositas mit ihren Langzeitfolgen ist ein zunehmendes Problem unserer heutigen Wohlstandsgesellschaft. Mit einer Verdoppelung der betroffenen Patienten im Laufe des 20. Jahrhunderts ist gleichzeitig durch rasante Verbesserung der bariatrischen Eingriffe auch die Zahl der Patienten signifikant und stetig gestiegen, die sich nach massiver Gewichtsreduktion nun mit neuem Leidensdruck beim Plastischen Chirurgen vorstellen. Hierbei ist die anfängliche Überzahl der weiblichen Patienten in ein ausgewogenes Verhältnis der betroffenen Geschlechter übergegangen. Die männliche Brust, eine Körperregion, die in erster Linie Männlichkeit und Stärke symbolisiert und

  14. Characterization of surface defects in high strength galvannealed steels; Charakterisierung der Oberflaechendefekte in hochfesten, nach dem Verzinken waermebehandelten Staehlen

    Energy Technology Data Exchange (ETDEWEB)

    Hong, M.H. [Automotive Steels Research Center, Technical Research Labs., POSCO, Gwangyang (Korea)

    2004-03-01

    Hot-dip galvannealed steel sheets, in which Fe of the substrate steel diffused into upper coating layer so as to be alloyed with Zn through a galvannealing above 450 C followed by hot-dip galvanizing process, generally show superior corrosion resistance, weldability and paintability. They have been widely used in automobile, construction, appliance industries and others. In particular, many researches have been carrying out to produce defect-free coating for an exposed automotive body panel. In the present study, high strength interstitial-free steel sheets containing Mn and P were galvannealed in an industrial continuous galvanizing line and defects on the coating surface were investigated by optical microscopy, scanning electron microscopy and transmission electron microscopy. It is clear that the quality of the substrate strongly affects galvannealed coating and it is essential to keep clean surface just before immediately dipping into molten Zn pot. (orig.) [German] Feuerverzinkte und danach waermebehandelte Stahlbleche, wo Fe aus dem Substratstahl in die obere Beschichtungsschicht diffundiert wie bei Legieren mit Zn und einer Waermebehandlung von ueber 450 C, gefolgt von einem Feuerverzinkverfahren, zeigen im Allgemeinen hervorragende Korrosionsbestaendigkeit, Schweissbarkeit und Anstreichbarkeit. Sie finden ein breites Einsatzgebiet bei Automobilen, im Bauwesen, in Werkzeugindustrien und anderen. Insbesondere wurde von vielen Forschern versucht, eine fehlerfreie Beschichtung fuer ein ungeschuetztes Karosserieteil herzustellen. In der vorliegenden Arbeit wurden hochfeste porenfreie Stahlbleche mit Mn- und P-Gehalt nach dem Verzinken in einer industriellen Endlos-Verzinkungslinie (CGL) waermebehandelt, wobei die Defekte auf der Schichtoberflaeche lichtmikroskopisch, rasterund transmissionselektronenmikroskopisch untersucht wurden. Klar ist, dass die Qualitaet des Substrats die nach dem Verzinken waermebehandelten Schichten beeinflusst und es ist von grosser

  15. Indirect MR-arthography in the fellow up of autologous osteochondral transplantation; Indirekte MR-Arthrographie zur Verlaufskontrolle nach autologer osteochondraler Transplantation

    Energy Technology Data Exchange (ETDEWEB)

    Herber, S.; Pitton, M.B.; Kalden, P.; Thelen, M.; Kreitner, K.F. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Radiologie; Runkel, M. [Mainz Univ. (Germany). Klinik und Poliklinik fuer Unfallchirurgie

    2003-02-01

    following autologous osteochondral transplantation. Assessment of transplant vitality, osseous fixation and stability is possible. (orig.) [German] Zielsetzung: Evaluation der Befunde nach indirekter MR-Arthrographie bei Patienten mit autologer osteochondraler Transplantation. Patienten und Methoden: 10 konsekutive Patienten mit einer Mosaik-Plastik wurden drei, 6 und 12 Monate nach dem Eingriff mittels indirekter MR-Arthrographie untersucht. Das MR-Protokoll bei 1,5T beinhaltete neben nativen PD- und T{sub 2}-gewichteten TSE-Sequenzen mit und ohne Fett-Suppression T{sub 1}-gewichtete, fettsupprimierte SE-Sequenzen vor und unmittelbar nach Kontrastmittelgabe sowie nach Bewegung des Gelenkes. Die Bildanalyse wurde gemeinsam von zwei Radiologen durchgefuehrt und beinhaltete die Auswertung der Signalintensitaet (SI) und Integritaet des knoechernen Zylinders ebenso wie der Knorpeloberflaeche, das Vorhandensein eines Knochenmarkoedems und eines Gelenkergusses. Ergebnisse: Drei Monate nach dem Eingriff zeigte sich in allen Faellen in der T{sub 2}-TSE-Sequenz ein ausgepraegtes Knochenmarkoedem auf Empfaenger- und Donorseite, korrespondierend zu einem deutlichem Signalintensitaetsanstieg nach Kontrastmittelgabe. Die Grenzzone zwischen dem Transplantat und dem originaerem Knochen zeigte eine erhoehte SI nach drei und 6 Monaten in der T{sub 2}-TSE-Sequenz sowie nach i.v. Gd-DTPA-Gabe. Eine Transplantatdislokation wurde in keinem Fall beobachtet. Als Zeichen der Vitalitaet des osteochondralen Transplantats normalisierte sich das Marksignal in der T{sub 1}-SE-Sequenz in den meisten Faellen nach 6 bzw. 12 Monaten. Die indirekte MR-Arthrographie war dem Nativ-Scan ueberlegen bei der Beurteilung der knorpeligen Ueberdeckung des Transplantats. In allen Faellen zeigte sich eine komplette Ueberdeckung des knoechernen Zylinders mit Gelenkknorpel. Transplantierter und originaerer hyaliner Knorpel zeigten einen deutlichen Anstieg der SI in der indirekten MR-Arthrographie. Signalalterationen und

  16. Lassen Veränderungen des Prostata-spezifischen Antigen- (PSA- Spiegels nach Prostatastanzbiopsie Rückschlüsse auf das pathologische Ergebnis zu?

    Directory of Open Access Journals (Sweden)

    Volkmer BG

    2004-01-01

    Full Text Available Einleitung: Die diagnostische Biopsie der Prostata führt bekanntermaßen zum Anstieg des Serum-PSA-Spiegels. Diese prospektive Untersuchung sollte die Frage klären, ob die Änderungen des Serum-PSA-Spiegels nach Stanzbiopsie Rückschlüsse auf das histologische Ergebnis zulassen und so als Entscheidungshilfe bei der Frage der Rebiopsie dienen können. Patienten und Methoden: Insgesamt 79 konsekutive Patienten mit klinischem Verdacht auf das Vorliegen eines Prostatakarzinoms (PCA und einem Gesamt-PSA 50 ng/ml wurden in die Studie eingeschlossen. Ausschlußkriterien waren klinische Hinweise für eine Prostatitis und Prostatabiopsie innerhalb der letzten 3 Monate. Die Serum-PSA-Werte wurden mit einem ultrasensitiven Enzymimmunoassay bestimmt. Die Bestimmung des Gesamt-PSA und des freien PSA im Serum erfolgte unmittelbar vor und 60 Minuten nach der Biopsie. Die Spiegel des Gesamt-PSA und freien PSA, sowie die f/t-PSA-Ratio vor und nach Biopsie wurden in Korrelation zum histologischen Ergebnis gesetzt. Ergebnisse: 86 Biopsieserien wurden bei 79 Patienten durchgeführt. 38 Biopsieserien diagnostizierten ein PCA, 48 eine benigne Prostatahyperplasie (BPH. Die abschließende Histologie nach wiederholter Biopsie war PCA und BPH in je 43 Fällen. Insgesamt fand sich ein Anstieg des durchschnittlichen Gesamt-PSA von 18,39 ng/ml auf 107,8 ng/ml, des durchschnittlichen freien PSA von 3,43 ng/ml auf 33,7 ng/ml und der durchschnittlichen f/t PSA-Ratio von 18,1 % auf 52,0 %. Es fand sich keine Korrelation zwischen dem Anstieg dieser Parameter und der Anzahl der Biopsiezylinder (4–51. Bezüglich des histologischen Befundes ergaben sich statistisch signifikante Unterschiede für das Gesamt-PSA vor und die f/t PSA-Ratio vor und nach Stanzbiopsie. Schlußfolgerung: Die Analyse der PSA-Parameter nach Stanzbiopsie bietet keine zusätzliche Information über die konventionellen PSA-Parameter vor der Biopsie hinaus. Sie korrelieren vor allem nicht mit falsch

  17. Assessment of cognitive functions after prophylactic and therapeutic whole brain irradiation using neuropsychological testing; Erfassung kognitiver Funktionen nach prophylaktischer und therapeutischer Ganzhirnbestrahlung mittels neuropsychologischer Testverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Penitzka, S.; Wannenmacher, M. [Universitaetsklinikum Heidelberg (Germany). Abt. Klinische Radiologie; Steinvorth, S. [Universitaetsklinikum Heidelberg (Germany). Abt. Klinische Radiologie; MIT, Cambridge, MT (United States). Dept. of Brain and Cognitive Sciences; Sehlleier, S. [Universitaetsklinikum Heidelberg (Germany). Abt. Klinische Radiologie; Universitaetsklinikum Wuerzburg (Germany). Abt. Strahlentherapie; Fuss, M. [Universitaetsklinikum Heidelberg (Germany). Abt. Klinische Radiologie; Texas Univ., San Antonio, TX (United States). Health Science Center; Wenz, F. [Universitaetsklinikum Heidelberg (Germany). Abt. Klinische Radiologie; Universitaetsklinikum Mannheim (Germany). Sektion Radioonkologie

    2002-05-01

    Purpose: Aim of this study was the assessment of neuropsychological changes after whole brain irradiation. Patients and Method: 64 patients were tested before, and 29 after whole brain irradiation, including 28 patients with small cell lung cancer (SCLC) before prophylactic cranial irradiation (PCI) and 36 patients with cerebral metastases before therapeutic cranial irradiation (TCI), as well as 14 patients after PCI and 15 after TCI (Table 1). Intelligence, attention and memory were assessed applying a 90-minute test battery of standardized, neuropsychological tests (Table 3). Results: Patients with SCLC showed test results significantly below average before PCI (n=28, mean IQ=83, SD=17). Neither after PCI, nor after TCI the tested neuropsychological functions decreased significantly (Tables 4, 5). A comparison between SCLC-patients with and without cerebral metastases before whole brain irradiation showed better test-results in patients with cerebral metastases and fewer cycles of preceding chemotherapy (Table 7). Conclusion: Neuropsychological capacity in patients with SCLC was impaired even before PCI. Possible reason is the preceding chemotherapy. Whole brain irradiation did not induce a significant decline of cognitive functions in patients with PCI or TCI. A decline in a longer follow-up nevertheless seems possible. (orig.) [German] Zielsetzung: Ziel der Studie war die Erfassung moeglicher Veraenderungen der neuropsychologischen Leistungsfaehigkeit nach Ganzhirnbestrahlung. Patienten und Methode: Untersucht wurden 64 Patienten vor und 29 Patienten nach Ganzhirnbestrahlung. Es handelte sich um 28 Patienten mit kleinzelligem Bronchialkarzinom (SCLC) vor prophylaktischer Ganzhirnbestrahlung (PCI) und um 36 Patienten mit Hirnmetastasen vor therapeutischer Ganzhirnbestrahlung (TCI). Es wurden 14 Patienten nach PCI und 15 Patienten nach TCI getestet. Zur Anwendung kam eine 90-minuetige Testbatterie standardisierter, neuropsychologischer Testverfahren zur Messung

  18. Predictive parameters of infectiologic complications in patients after TIPSS; Praediktive Parameter infektiologischer Komplikationen bei Patienten nach TIPSS-Anlage

    Energy Technology Data Exchange (ETDEWEB)

    Cohnen, M.; Saleh, A.; Moedder, U. [Institut fuer Diagnostische Radiologie, Universitaetsklinikum Duesseldorf (Germany); Luethen, R.; Bode, J.; Haeussinger, D. [Klinik fuer Gastroenterologie, Hepatologie und Infektiologie, Universitaetsklinikum Duesseldorf (Germany); Daeubener, W. [Institut fuer Mikrobiologie und Virologie, Universitaetsklinikum Duesseldorf (Germany)

    2003-02-01

    Aim To define predictive parameters of a complicated clinical course after the TIPSS procedure. Blood cultures were drawn prospectively in 41 patients from a central line and from the portal venous blood before stent placement as well as from the central line 20 min after intervention. C-reactive proteine (CRP) (mg/dl) and white blood cell count (WBC,/{mu}l) on the day of TIPSS-procedure (d0), the first (d1) and seven (d7) days after TIPSS were compared in patients with a complicated clinical course (spontaneous bacterial peritonitis, pneumonia, sepsis; group I) to patients without clinical complications (group II) Group I showed a significant increase in CRP (d0: 1.8{+-}1.0; d1: 3.2{+-}1.5; d7: 4.3{+-}3.2), and white blood cell count (d0: 7700{+-}2600; d1: 10800{+-}2800; d7: 7500{+-}1800) on the first day after TIPSS-procedure in comparison to group II (CRP: d0: 1.6{+-}0.6; d1: 1.8{+-}1.0; d7: 1.9{+-}0.6. WBC: d0: 6900{+-}1500; d1: 8000{+-}1600; d7: 7600{+-}1400).Microbiological analysis showed in 12% skin or oral flora in the last sample. The course of CRP and WBC-count during the first week after TIPSS procedure may indicate patients with a potential risk of a complicated clinical course. (orig.) [German] Fragestellung Definition praediktiver Parameter infektiologischer Komplikationen bei Patienten nach TIPSS-Anlage.Methodik Bei 41 Patienten wurden Blutproben prospektiv vor intrahepatischer Stentanlage zentralvenoes und portalvenoes sowie 20 min postinterventionell erneut zentralvenoes entnommen und mikrobiologisch analysiert. C-reaktives Protein (CRP) (mg/dl) und Leukozytenzahl (/{mu}l) wurden am Interventionstag (d0), am 1. (d1) sowie 7 Tage (d7) postinterventionell bestimmt. Patienten mit kompliziertem Verlauf (spontane bakterielle Peritonitis,Pneumonie, Sepsis; Gruppe 1) wurden von Patienten ohne klinische Komplikationen (Gruppe 2) unterschieden.Ergebnisse Gruppe 1 wies einen signifikanten Anstieg des CRP (d0: 1,8{+-}1,0; d1: 3,2{+-}1,5; d7: 4,3{+-}3,2) und

  19. Effect of long-term inhalation of uranium dust on balance of certain metabolites and enzymes of Krebs cycle on rat kidney tissues

    International Nuclear Information System (INIS)

    Sarsenova, L.K.; Mustafina, R.Kh.

    2010-01-01

    Kidney is the main organ for transportation and cumulation of soluble radioactive nuclides. The changing of bioenergetic processes has the most value for investigation of kidney infringements nature. Purpose of study: exploring the changing dynamics of Krebs cycle dehydrogenases activity and of tricarbonic acid content in rat kidney tissues after long-term inhalation of Uranium ore dust (UOD) for 10 mpc and application of licorice root aqueous solution. The investigation had been performed on winter breeding white out bred male rats which body weight was 120-140 g. UOD inhalation had been conducted in exposure chamber during the 120 days,4 hours per day 5 days per week. Licorice root aqueous solution was injected per os in dose 100 mg/kg 30 days after the inhalation. Isocitric (ICA) and malic acids (MA) were quantified by Hohorost enzymatic method. Activity rate of a-Ketoglutarate, Malat, Succinate and Isocitrate dehydrogenases (AKDG, MDG, SDG, IDG) in the kidney tissue was determined by Kun and Abood method in modification of Oda and Okazaki and Natochin, and assessed by reduction of Neotetrazolium. As control groups intact rats (norm) and intact animals (control) which stood in exposure chamber without UOD 4 hours/day 5 days in week were serving. Each group of 6-10 animals consisted. Data was processed statistically. At UOD inhalation in 10 mpc doze during the first 30 days the ICA content level has decreased more than in 2 times, by 90-th days this indicator has grown in 4 times and has exceeded control on 70 %. By the experiment end for 120 days the level of ICA has decreased, coming nearer to the control. Decrease in concentration of the MA was longer. The decrease maximum - in 2,2 times - has been fixed for 90-s' days of an inhalation. In the subsequent term - to the 120-th day -there was an increase of concentration to the level comparable to the control. Character and depth of radiation influence of the long inhalation of UOD are shown by change of a parity

  20. MR imaging of the lateral collateral ligaments after ankle sprain; Aussenbandrupturen des Sprunggelenkes - Darstellung mit der MRT vor und nach funktioneller Therapie

    Energy Technology Data Exchange (ETDEWEB)

    Grebe, P. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Kreitner, K.F. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Roeder, W. [Abt. fuer Chirurgie, St-Hildegardis-Krankenhaus, Mainz (Germany); Kersjes, W. [Klinik fuer Radiologie der Universitaetsklinik, Mainz (Germany); Hennes, R. [Abt. fuer Allgemein- und Unfallchirurgie, St. Josefshospital, Wiesbaden (Germany); Runkel, M. [Unfallchirurgische Klinik der Unversitaetsklinik, Mainz (Germany)

    1995-09-01

    35 patients with ankle sprain were examined by MRI and stress radiographs. 13 were operated afterwards, 22 patients underwent a functional conservative therapy and were examined by MRI and stress radiographs and second time after three months. MRI reports were correct in 12 of 13 operated cases. After conservative therapy we did not find any disrupted ankle ligament. MRI showed intact ligaments thickened by scar. (orig./MG) [Deutsch] 35 Patienten mit klinischem Verdacht auf Aussenbandruptur wurden mit der MRT untersucht. 13 Patienten wurden operiert, 22 konzervativ therapiert. Letztere wurden nach drei Monaten erneut mit MRT und gehaltenen Aufnahmen untersucht. Die MRT-Befunde stimmten in 12 von 13 Faellen mit den operativ erhobenen Befunden ueberein. Nach dreimonatiger konzervativer Therapie waren alle 22 Sprunggelenke stabil. Die rupturierten Baender stellten sich verdickt und durchgaengig dar. (orig./MG)

  1. Radiological findings, evaluation and treatment of patellofemoral pain after total knee arthroplasty; Radiologische Diagnostik, Beurteilung und Behandlung des patellofemoralen Schmerzes nach primaerer Knieendoprothetik

    Energy Technology Data Exchange (ETDEWEB)

    Springorum, H.R.; Keshmiri, A.; Heers, G.; Renkawitz, T.; Grifka, J.; Baier, C. [Asklepios Klinikum Bad Abbach, Orthopaedische Klinik fuer die Universitaet Regensburg, Bad Abbach (Germany)

    2012-11-15

    Total knee arthroplasty (TKA) is one of the most successful operative procedures over the last decades in orthopedic surgery; however, some patients suffer from pain, limited range of motion, instability, infections or other complications postoperatively. Patellofemoral pain (PFP) in particular is a common problem after TKA and often necessitates revision surgery. Mainly increasing and localized contact pressure and patella maltracking are held responsible for PFP but the reasons vary. Diagnostics and therapy of PFP is not easy to manage and should be treated following a clinical pathway. The authors suggest that patients with PFP should be categorized after basic diagnostic measures according to the suspected diagnosis: (1) tendinosis, (2) mechanical reasons, (3) intra-articular non-mechanical reasons and (4) neurogenic/psychiatric reasons. Efficient application of special diagnostic measures and further therapy is facilitated by this classification. (orig.) [German] Die endoprothetische Versorgung des Kniegelenks ist eine Operation mit hohem Zugewinn an Lebensqualitaet. Dennoch sind je nach Literaturstelle bis zu 50% der Patienten von Schmerzen, Bewegungseinschraenkung, Instabilitaet, Infektion oder anderen Komplikationen betroffen. Insbesondere der patellofemorale Schmerz (PFS) ist eine haeufige Komplikation nach primaerer Knieendoprothetik und wird je nach Literatur mit 1-50% der Faelle angegeben. Insbesondere der erhoehte retropatellare Anpressdruck und eine schlechte Fuehrung der Patella werden fuer den PFS verantwortlich gemacht, doch die Ursachen sind vielfaeltig. Diagnostik und Behandlung sind komplex und sollten strukturiert durchgefuehrt werden. Nach der Basisdiagnostik schlagen die Autoren daher eine Einteilung in eine der 4 Gruppen vor: (1) Tendinosen, (2) mechanische Probleme, (3) intraartikulaere nichtmechanische Probleme, (4) neurogene/psychische Probleme. Durch die Einteilung in diese verschiedenen Gruppen werden eine effiziente spezielle

  2. Information to go: Kommunikation im Prozess der Migration am Beispiel syrischer und irakischer Flüchtlinge auf ihrem Weg nach Deutschland

    Directory of Open Access Journals (Sweden)

    Anke Fiedler

    2016-07-01

    Full Text Available Vor dem Hintergrund der Flüchtlingsdebatte in Deutschland 2015 wird in diesem Beitrag danach gefragt, welche (Massen-Kommunikationskanäle Flüchtlinge vor, während und nach der Flucht nutzen, um sich über migrationsrelevante Themen zu informieren und sich darüber mit anderen Migrationswilligen auszutauschen. Dabei wird nicht nur die Frage nach der subjektiven Bewertung der genutzten Quellen gestellt, sondern auch untersucht, ob die Flüchtlinge eine informierte Entscheidung in den verschiedenen Phasen der Migration treffen. Auf Basis des Uses-and-Gratifications-Ansatzes und der Handlungstheorie (symbolischer Interaktionismus wurden zwischen November 2015 und Februar 2016 vier Fokusgruppen und 36 Tiefeninterviews mit syrischen und irakischen Flüchtlingen durchgeführt. Die Ergebnisse verdeutlichen, dass sich die befragten Flüchtlinge vor und während der Flucht gut informiert fühlten, da persönliche Kontakte und soziale Medien die Informationsbedürfnisse weitgehend befriedigen konnten. Informationsdefizite zeigten sich vor allem nach der Ankunft in Deutschland.

  3. Feministische Gesellschaftstheorie und die Suche nach der Anschlussfähigkeit Feminist Social Theory in Search of Connections

    Directory of Open Access Journals (Sweden)

    Silke Schneider

    2002-07-01

    Full Text Available Der Sammelband „Soziale Verortung der Geschlechter“ stellt einen Querschnitt aktueller feministischer Theoriediskussionen vor. Dass bei der Suche nach angemessenen gesellschaftsanalytischen Kategorien sowohl die Klassiker/-innen der Politischen Theorie und Gesellschaftstheorie wie auch ihre Epigonen mannigfache Kritik-, aber auch vielversprechende Anschlußpunkte zu bieten haben, vermögen alle Beiträge zu vermitteln. Somit bietet der Band mit seiner breit angelegten Konzeption, die wichtige und durchaus gegensätzliche Theorien verbindet, einen guten Überblick und regt gleichzeitig zur vertiefenden Lektüre an. Bemerkenswert ist, dass nahezu alle Beiträge für eine Verbindung von Empirie und Theorie plädieren und hierbei die Einbeziehung einer historischen Perspektive als grundlegend und unabdingbar für eine Analyse der Geschlechterverhältnisse als Teil gesellschaftlicher Entwicklung erachtet wird.The anthology “The Social Positionings of Gender” presents a cross section of current debates in feminist theory. The authors show how authors of classical political and social theory as well as their successors offer plenty of room for criticism, but also promising starting points in the search for appropriate socio-analytic categories. This anthology not only offers a good overview over current theory by connecting different (and at times contradicting schools of thought, but also inspires to engage in further reading on these issues. What is particularly remarkable about this work is that almost all of the contributions plead for a combination of empirical research and theoretical work, as they consider the inclusion of a historical perspective as fundamental and indispensable for an analysis of gender relations as part of societal developments.

  4. Bathymetry and Near-River Topography of the Naches and Yakima Rivers at Union Gap and Selah Gap, Yakima County, Washington, August 2008

    Science.gov (United States)

    Mastin, M.C.; Fosness, R.L.

    2009-01-01

    Yakima County is collaborating with the Bureau of Reclamation on a study of the hydraulics and sediment-transport in the lower Naches River and in the Yakima River between Union Gap and Selah Gap in Washington. River bathymetry and topographic data of the river channels are needed for the study to construct hydraulic models. River survey data were available for most of the study area, but river bathymetry and near-river topography were not available for Selah Gap, near the confluence of the Naches and Yakima Rivers, and for Union Gap. In August 2008, the U.S. Geological Survey surveyed the areas where data were not available. If possible, the surveys were made with a boat-mounted, single-beam echo sounder attached to a survey-grade Real-Time Kinematic (RTK) global positioning system (GPS). An RTK GPS rover was used on a walking survey of the river banks, shallow river areas, and river bed areas that were impenetrable to the echo sounder because of high densities of macrophytes. After the data were edited, 95,654 bathymetric points from the boat survey with the echo sounder and 1,069 points from the walking survey with the GPS rover were used in the study. The points covered 4.6 kilometers on the Yakima River and 0.6 kilometers on the Naches River. GPS-surveyed points checked within 0.014 to 0.047 meters in the horizontal direction and -0.036 to 0.078 meters in the vertical direction compared to previously established survey control points

  5. Massenmedien und Versöhnung: Die Berichterstattung über den deutsch-französischen Friedensprozeß nach dem 2. Weltkrieg

    Directory of Open Access Journals (Sweden)

    Susanne Jaeger

    2003-10-01

    Full Text Available Der vorliegende Beitrag beinhaltet die ersten Ergebnisse einer Langzeitstudie, bei der flächendeckend die deutsche Nachkriegsberichterstattung über Frankreich von 1946 bis 1970 inhaltsanalytisch ausgewertet wurde. Die Studie stützt sich dabei auf das Modell der Nachrichtenfaktoren von Johan Galtung, welche nach seiner Ansicht die Auswahl der Themen bestimmen, die zu einer Nachricht werden. Genau in diesen Selektionsroutinen liegt jedoch die implizite Gefahr, Konflikte zu vertiefen statt sie einzudämmen bzw. durch ein breites Verständnis der Hintergründe gewaltfrei bearbeitbar zu machen. Für die Zeit nach einem Krieg könnten sie Hindernisse auf dem Weg zur Annäherung und Aussöhnung ehemaliger Gegner darstellen. Wie jedoch sieht die Berichterstattung nach dem Krieg tatsächlich aus? Zeigen Massenmedien Bereitschaft zu einer veränderten Berichterstattung? Der Fall der französisch-deutschen Aussöhnung, welcher als Beispiel für einen gelungenen Aussöhnungsprozess gelten kann, belegt, dass Friedensprozesse von den Medien durchaus adäquat begleitet werden können: Z.B. ist der Anteil "positiver" Themen bzw. Berichterstattung konsistent höher als der "negativer", und der Anteil von Non-Elite-Themen steigt an und kündet von Interesse an französischer Lebensart und Kultur. Die Ergebnisse zeigen, dass Negativismus in den Medien kein Naturgesetz ist, sondern überwunden werden kann, wenn Frieden und Versöhnung auf der Tagesordnung stehen.

  6. Beginn und Dosisanpassung einer intensivierten konventionellen Insulintherapie (ICT beim Erwachsenen

    Directory of Open Access Journals (Sweden)

    Lohr R

    2012-01-01

    Full Text Available Eine intensivierte Insulintherapie (ICT ist die Behandlung der Wahl bei Diabetes mellitus Typ 1 und auch bei vielen Menschen mit insulinpflichtigem Typ-2-Diabetes. Bei Therapiebeginn müssen individuell Insuline ausgewählt und die richtige Dosierung festgelegt werden. Im weiteren Verlauf ist dann die Anpassung der Insulintherapie an besondere Alltagssituationen wie Sport oder akute Erkrankungen vorrangig. Eine gute Patientenschulung und eine gute Zusammenarbeit zwischen Betroffenem und Behandlerteam sind entscheidend, um diese komplizierte Therapie erfolgreich umzusetzen.

  7. Imaging of appendicitis in adults; Bildgebung der Appendizitis beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Karul, M.; Berliner, C.; Keller, S.; Yamamura, J. [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of Diagnostic and Interventional Radiology; Tsui, T.Y. [University Medical Center Hamburg-Eppendorf, Hamburg (Germany). Dept. of General, Visceral- and Thoracic Surgery

    2014-06-15

    Three imaging modalities are available for the diagnosis of acute appendicitis: ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI). Transabdominal ultrasound should be the first-line imaging test. Abdominal CT is superior to US and is required immediately in patients with atypical clinical presentation of appendicitis and suspected perforation. However, low-dose unenhanced CT is equal to standard-dose CT with intravenous contrast agents in the detection of five signs of acute appendicitis (thickened appendiceal wall more than 2 mm, cross-sectional diameter greater than 6 mm, periappendicitis, abscess, and appendicolith). MRI is necessary in pregnant women and young adults. This review illustrates the principles of state-of-the-art imaging techniques and their clinical relevance. (orig.)

  8. PV systems: Things are improving again. Medium-sized enterprises are getting into the solar module business; Photovoltaik: Nach Talfahrt wieder aufwaerts. Mittelstaendische Firmen steigen ins Solarmodulgeschaeft ein

    Energy Technology Data Exchange (ETDEWEB)

    Lemme, H.

    1996-06-25

    At the 11th `Symposium for Photovoltaic Solar Energy Conversion`, which was held at Banz Monastery, the drastic decline of the German solar celll production was discussed. Especially the closing down of ASE Wedel gave rise to dark speculations. However, some experts think the problem will be solved now that several medium-sized enterprises have entered the solar market. (HW) [Deutsch] Auf dem elften `Symposium photovoltaische Solarenergie` im Kloster Benz wurde der drastische Rueckgang der deutschen Solarzellenproduktion diskutiert. Insbesondere bereitete die Schliessung des Wedeler ASE-Werkes einige Sorgen. Nach Meinung verschiedener Fachleute scheint sich das Problem jedoch zu loesen, nachdem mehrere mittelstaendische Betriebe auf dem Solarsektor eingestiegen sind. (HW)

  9. Modification of the method of Figgie for determination of joint line shifting in total knee arthroplasty; Modifizierung der Messmethode nach Figgie zur Bestimmung der Gelenklinienverschiebung in der Knieendoprothetik

    Energy Technology Data Exchange (ETDEWEB)

    Classen, T.; Wegner, A.; Knoch, M. von [Universitaet Duisburg-Essen, Klinik fuer Orthopaedie, Essen (Germany)

    2009-06-15

    An important factor for a good result after total knee arthroplasty is the position of the patella in relation to the tibiofemoral joint line. The position of the patella itself is not influenced by arthroplasty, therefore any changes in the position of the tibiofemoral joint line are of special interest. The Figgie method to describe patella height delivers only absolute measurements, which makes it difficult to compare different radiographs. For this reason we developed a new JL/P quotient (JL: distance from the tibial plateau to the tibial tubercle, P: distance from the inferior pole of the patella to the tibial plateau) to enable better comparison. Furthermore, we modified the JL/P quotient and instead of taking the tibial plateau as the reference line, we constructed a tangent on the femoral condyle. With this modification, problems such as tibial inlays of different heights which have to be taken into account in the measurements, the slope of the tibial component or difficult assessment of the tibial joint surface in osteoarthritic knees do not arise. The JL/P quotient shows massive shift to cranialisation of the tibiofemoral joint line which does not correspond to reality. The modified method also shows cranialisation of the tibiofemoral joint line, but in a realistic way. Both methods show a minimal interobserver variability. The modified JL/P quotient seems to be a good method for determining the shift in the tibiofemoral joint line after total knee arthroplasty. (orig.) [German] Ein bedeutender Faktor fuer ein gutes postoperatives Ergebnis nach einer Knieendoprothesenimplantation ist die Stellung der Patella in Relation zur tibiofemoralen Gelenklinie. Da die Stellung der Patella durch den operativen Eingriff primaer nicht beeinflusst wird, liegt besonderes Augenmerk auf den Veraenderungen der Gelenklinie des Tibiofemoralgelenks. Die Messmethode zur Bestimmung der Patellahoehe nach Figgie liefert dafuer nur absolute Werte, was eine Vergleichbarkeit von

  10. Radiotherapy in early stage dupuytren's contracture; Die Radiotherapie des Morbus Dupuytren im Fruehstadium. Langzeitresultate nach einer medianen Nachbeobachtungszeit von 10 Jahren

    Energy Technology Data Exchange (ETDEWEB)

    Adamietz, B.; Sauer, R. [Erlangen-Nuernberg Univ., Erlangen (Germany). Klinik und Poliklinik fuer Strahlentherapie; Keilholz, L. [Erlangen-Nuernberg Univ., Erlangen (Germany). Klinik und Poliklinik fuer Strahlentherapie; Praxis fuer Strahlentherapie, Klinikum Fuerth (Germany); Gruenert, J. [Abt. fuer Plastische und Handchirurgie der Chirurgischen Universitaetsklinik Erlangen-Nuernberg, Erlangen (Germany)

    2001-11-01

    Purpose: In early stage Dupuytren's contracture radiotherapy was applied to prevent disease progression. Long-term results and late toxicity of this treatment were evaluated in a retrospective analysis. Patients and Methods: Between 1982 and 1994, 99 patients (176 hands) received orthovoltage radiotherapy, which consisted of two courses with 5 x 3 Gy (total dose: 30 Gy, daily fractionated; 120 kV, 4 mm Al), separated by a 6 to 8-week pause. The Dupuytren's contracture was staged according to the classification of Tubiana et al. The long-term outcome was analyzed at last follow-up between July and November 1999. The median follow-up was 10 years (range 7-18 years). Late toxicity was assessed using the LENT-SOMA criteria. Results: In Stage N 84% and Stage N/I 67% of cases remained stable. 65% of the cases in Stage I and 83% in Stage II showed progressive nodules and cords. In case of progression we saw no complications after a second radiotherapy or salvage operation. Conclusion: Radiotherapy effectively prevents disease progression for early stage Dupuytren's contracture (Stage N, N/I). Moreover, in case of disease progression despite radiotherapy salvage surgery is still feasible. (orig.) [German] Hintergrund: Im Fruehstadium des Morbus Dupuytren wird die externe Radiotherapie mit dem Ziel eingesetzt, den progressiven Verlauf der Erkrankung zu verhindern. Eine aktuelle Langzeitverlaufskontrolle soll die Ergebnisse und Nebenwirkungen der Radiotherapie darstellen. Patienten und Methode: Wir untersuchten 99 Patienten (176 Haende), welche sich von 1982-1994 einer Radiotherapie an unserer Klinik unterzogen. Jeder Patient erhielt zwei Serien einer Radiotherapie mit jeweils 5 x 3 Gy (Gesamtdosis 30 Gy, 120 kV, 4 mm Al, Bestrahlungspause von 6-8 Wochen nach 15 Gy). Die Beugekontraktur wurde nach Tubiana et al. eingeteilt. Von Juli bis November 1999 erfolgte nach einer medianen Nachbeobachtungszeit von 10 Jahren (7-18 Jahre) eine Kontrolluntersuchung. Die

  11. Die Struktur der Handgesten im indischen Tanz nach dem „Nāṭya-Śāstra“ des Bharata (NŚBh)

    OpenAIRE

    Müller, Biliana

    2008-01-01

    In der vorliegenden Untersuchung wird eine Strukturanalyse der Gestensprache im indischen Tanz nach einem schriftlich vorliegenden Text vorgeschlagen – dem neunten Kapitel des ‚Nāṭya-Śāstra‘ eines legendären Autors namens Bharata. Der untersuchte Text ist Zeugnis für ein Zeichensystem, das über mehr als zwei Jahrtausende als Basis für die symbolische Interaktion auf dem indischen Subkontinent gedient hat und heute in zahlreichen Variationen präsent ist. Dieses Zeichensystem ist im semiotische...

  12. The α7-nACh nicotinic receptor and its role in memory and selected diseases of the central nervous system

    Directory of Open Access Journals (Sweden)

    Urszula Baranowska

    2017-07-01

    Full Text Available α7-nACh is one of the major nicotinic cholinergic receptor subtypes found in the brain. It is broadly expressed in the hippocampal and cortical neurons, the regions which play a key role in memory formation. Although α7-nACh receptors may serve as postsynaptic receptors mediating classical neurotransmission, they usually function as presynaptic modulators responsible for the release of other neurotransmitters, such as glutamate, γ-aminobutyric acid, dopamine, and norepinephrine. They can, therefore, affect a wide array of neurobiological functions. In recent years, research has found that a large number of agonists and positive allosteric modulators of α7-nAChR induce beneficial effects on learning and memory. Consistently, mice deficient in chrna7 (the gene encoding α7-nAChR protein, are characterized by memory deficits. In addition, decreased expression and function of α7-nAChR is associated agoniwith many neurological diseases including schizophrenia, bipolar disorder, learning disability, attention deficit hyperactivity disorder, Alzheimer disease, autism, and epilepsy. In the recent years many animal experiments and clinical trials using α7-nAChR ligands were conducted. The results of these studies strongly indicate that agonists and positive allosteric modulators of α7-nAChR are promising therapeutic agents for diseases associated with cognitive deficits.

  13. Mechanical-biological waste conditioning with controlled venting - the Meisenheim mechanical-biological waste conditioning plant; Mechanisch-biologische Restabfallbehandlung nach dem Kaminzugverfahren - MBRA Meisenheim

    Energy Technology Data Exchange (ETDEWEB)

    Hangen, H.O. [Abfallwirtschaftsbetrieb Landkreis Bad Kreuznach, Bad Kreuznach (Germany)

    1998-12-31

    The decision of the rural district of Bad Kreuznach to propose creating facilities for mechanical-biological waste conditioning at the new northern Meisenheim landfill was consistent and correct. It will ensure that the material deposited at this new, state-of-the-art landfill is organically `lean` and can be deposited with a high density. Preliminary sifting of the material prior to depositing safeguards that no improper components are inadvertently included. Three years of operation warrant the statement that waste components that cannot be appropriately biologically conditioned should be eliminated prior to rotting. (orig.) [Deutsch] Die Entscheidung des Landkreises Bad Kreuznach, der neu eingerichteten Norddeponie Meisenheim eine MBRA vorzuschlaten, war auf jeden Fall konsequent und richtig. Es ist damit sicher gestellt, dass in diesem neuen nach dem Stand der Technik eingerichteten Deponiebereich von Anfang an ein Material eingelagert wird, das `organisch abgemagert` ist und mit hoher Einbaudichte eingebaut werden kann. Die Sichtung des gesamten Deponie-Inputs in der Vorsortierhalle gibt ein Stueck Sicherheit, dass keine nicht zugelassenen Stoffe verdeckt dem Ablagerungsbereich der Deponie zugefuehrt werden. Nach mehr als 3 Jahren Betriebszeit kann festgestellt werden, dass biologisch nicht sinnvoll behandelbare Abfallbestandteile vor dem Rotteprozess abgetrennt werden sollten. (orig.)

  14. Sacherschliessung nach RDA

    Directory of Open Access Journals (Sweden)

    Hans Schürmann

    2015-05-01

    Full Text Available Die Resource Description and Access (RDA wird für den deutschsprachigen Raum das neue Regelwerk für die bibliothekarische Erschliessung der Bestände. In diesem Regelwerk wird auch die Sacherschliessung neu geregelt. Zurzeit sind diese Seiten noch leer. Doch wie soll ein Regelwerk für die Sacherschliessung aussehen? Kriterien für eine Regelung fehlen, zu stark hat sich das Umfeld der Inhaltserschliessung in den letzten Jahren geändert. Auch von der Schlagworttheorie her sind noch keine Hinweise in Sicht. Deshalb wird in verschiedenen Gremien intensiv diskutiert, wie eine zukunftsfähige Sacherschliessung aussehen könnte. In welchem Rahmen bewegt sich die Diskussion und woran soll sich die Regelwerksentwicklung für den Sachkatalog orientieren? Der Beitrag erwägt zwischen der Sachkataloggeschichte einerseits und dem modernen Datenmanagement im Netz andererseits die Bedeutung und die Rolle eines Sacherschliessungsregelwerks. Resource Description and Access (RDA will be the new standard for descriptive cataloguing in the German-speaking countries. Under RDA, subject indexing will also be redefined, although, at present, the relevant pages remain blank. This article ponders the question what these new standards could look like. As yet no clear criteria have emerged – the field of subject indexing has undergone too much change in recent years for that. Nor does the theory appear to offer any answers at the moment. There is therefore intensive and ongoing debate in the various forums. What is the framework of these discussions and what are the key criteria? The article summarizes them and considers the importance of indexing standards in the light of both the history of indexing and modern data management on the web.

  15. RESEARCH ON THE INFLUENCE OF H+ IONS CONCENTRATION ON THE DYNAMICS OF THE ACTIVITIES OF CERTAIN DEHYDROGENASES OF THE KREBS CYCLE IN THE MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS PARASITIC ON PLUM TREES

    Directory of Open Access Journals (Sweden)

    Tutu Elena

    2010-09-01

    Full Text Available During the process of nutrition, thus in that of their growth, microorganisms are subject to the influences of certain environmental factors that condition the microbial activity determining either the growth and reproduction, or the inhibition of activity and the inactivation of microorganisms. A well known means of expressing the H+ ions concentration in a certain environment is the pH, an important chemical factor that is closely observed when growing ascomycetes, for any alteration of its value entails conformational alterations of their enzymes, the characteristics of the substrate, such that they can no longer interact with the active site of the enzyme or be subject to catalysis. The present study comprises the results of our research on certain oxidoreductase implied in the steps of the Krebs cycle in the Monilinia laxa (Aderh.&Ruhl. Honey, a fungus that parasites the prune. The enzymatic determinations took place at 7 and 14 days from the mycelium of the fungus cultivated in Leonian media, whose pH was adjusted to values between 2.0 and 9.0 by using NaOH 1N and HCl 0,1N solutions. We registered different values of the dehydrogenasic activity, directly correlated with the physiological condition of the fungus (given its age and with the initial pH value of the culture’s environment.

  16. RESEARCH ON THE INFLUENCE OF H+ IONS CONCENTRATION ON THE DYNAMICS OF THE ACTIVITIES OF CERTAIN DEHYDROGENASES OF THE KREBS CYCLE IN THE MONILINIA LAXA (ADERH. & RUHL. HONEY FUNGUS PARASITIC ON PLUM TREES

    Directory of Open Access Journals (Sweden)

    Elena Tutu

    2011-11-01

    Full Text Available During the process of nutrition, thus in that of their growth, microorganisms are subject to the influences of certain environmental factors that condition the microbial activity determining either the growth and reproduction, or the inhibition of activity and the inactivation of microorganisms. A well known means of expressing the H+ ions concentration in a certain environment is the pH, an important chemical factor that is closely observed when growing ascomycetes, for any alteration of its value entails conformational alterations of their enzymes, the characteristics of the substrate, such that they can no longer interact with the active site of the enzyme or be subject to catalysis. The present study comprises the results of our research on certain oxidoreductase implied in the steps of the Krebs cycle in the Monilinia laxa (Aderh.&Ruhl. Honey, a fungus that parasites the prune. The enzymatic determinations took place at 7 and 14 days from the mycelium of the fungus cultivated in Leonian media, whose pH was adjusted to values between 2.0 and 9.0 by using NaOH 1N and HCl 0,1N solutions. We registered different values of the dehydrogenasic activity, directly correlated with the physiological condition of the fungus (given its age and with the initial pH value of the culture’s environment.

  17. Functional MRI of the pelvic floor: postpartum changes of primiparous women after spontaneous vaginal delivery; Funktionelle Magnetresonanztomographie (MRT) des Beckenbodens: Postpartale Veraenderungen bei Erstgebaerenden nach vaginaler Spontangeburt

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    Lienemann, A.; Fischer, T.; Reiser, M. [Inst. fuer Klinische Radiologie, Klinikum der Univ. Muenchen (Germany); Anthuber, C. [Klinik und Poliklinik fuer Geburtshilfe und Frauenheilkunde, Klinikum der Univ. Muenchen/Grosshadern (Germany)

    2003-08-01

    Purpose: Detection of morphological and functional changes of the pelvic floor with functional MRI in primiparous women after spontaneous vaginal delivery. Methods and Materials: The study comprises 26 primiparous women after vaginal delivery and a control group of 41 healthy asymptomatic nulliparous volunteers. MRI was performed on a 1.5 T system in supine position with vagina and rectum opacified with Sonogel. The static images consisted of sagittal and axial T{sub 2}-weighted SE sequences and functional images of true FISP sequences in midsagittal and axial planes acquired with the patient at rest, straining and during defecation. Evaluation of morphometric parameters included pelvimetry, thickness of the puborectal muscle and width of the urogenital hiatus as well as position and movement of the pelvic organs relative to the pubococcygeal reference line. Results: The configuration of the bony pelvis did not differ for both groups. The puborectal muscle was significantly thinner in the study group (0.8 cm vs 0.6 cm). The functional images showed no significant differences between both groups at rest but a significantly increased incidence in the descent of the bladder neck, vaginal fornix and anorectal junction in the study group during straining. In addition, the primiparous women had more prominent rectoceles (0.6 cm vs 1.5 cm). Conclusion: Static imaging alone fails to demonstrate relevant pelvic floor changes and a functional method is necessary to evaluate the interactions of the pelvic organs regarding organ descent. Functional MRI of the pelvic floor is an excellent method to reveal the significant changes of the pelvic floor after vaginal birth without exposing the uterus to radiation. (orig.) [German] Ziel: Darstellung von morphologischen und funktionellen Veraenderungen am Beckenboden bei Erstgebaerenden nach spontanvaginaler Entbindung mittels funktioneller MRT. Methodik: Funktionelle MRT des Beckenbodens von 26 Erstgebaerenden nach vaginaler

  18. Computed tomography of the patellofemoral alignment after arthroscopic reconstruction following patella dislocation; Postoperative Bestimmung des patellofemoralen Alignements nach Patellaluxation - eine computertomographische Analyse

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    Schroeder, R.J.; Hidajat, N.; Maeurer, J.; Felix, R. [Klinik fuer Strahlenheilkunde, Charite, Campus Virchow-Klinikum, Humboldt-Univ. Berlin (Germany); Weiler, A.; Hoeher, J. [Sektion Sporttraumatologie und Arthroskopie, Klinik fuer Unfall- und Wiederherstellungschirurgie, Charite, Campus Virchow-Klinikum, Humboldt-Univ. Berlin (Germany)

    2003-04-01

    Purpose: To evaluate the diagnostic impact of different CT-based measurements to analyze the patellofemoral alignment after arthroscopic reconstruction in patients with patella dislocation. Materials and Methods: In 18 patients with dislocation of the patella, CT of the patellofemoral joint was performed after arthroscopic reconstruction. Various methods recommended in the literature were used to analyze the structure and the alignment of the patellofemoral joint with a relaxed quadriceps muscle. Axial CT scans were taken in four different knee flexion angles (15 , 30 , 45 , 60 ). Results: After arthroscopic stabilization in patients with patella dislocation, only the lateral patellofemoral angle (15 and 30 knee flexion) and the congruence angle (15 knee flexion) showed significant differences between the CT-measurements in the normal and the operated group. The differences of the remaining mean values were not significant due to a high standard deviation. With increasing flexion of the knee, the differences between the normal and the dislocation group almost disappeared. Only the lateral patellofemoral angle, the patella tilt and the lateral patella shift revealed differences between the normal and the group with recurrent dislocation in every degree of knee flexion. With increasing knee flexion above 30 and especially at 60 , the majority of the measured values returned to the normal range. Conclusions: For CT-measurements of the patellofemoral joint after arthroscopic stabilization, the patellofemoral angle and the congruence angle seemed to be most useful. The measurements of the patellofemoral joint should be taken in various degrees of knee flexion. (orig.) [German] Ziel: Evaluation der Aussagekraft verschiedener CT-Vermessungsmethoden des Patellofemoralgelenkes nach arthroskopischer Stabilisierung bei Patellaluxation. Material und Methode: Axiale CT-Vermessung des Patellofemoralgelenkes bei 18 Patienten nach arthroskopischer medialer patellofemoraler Naht

  19. Thyroid volume reduction following radioiodine therapy in patients with autonomous goitre and Graves` disease; Volumenreduktion der Schilddruese nach Radiojodtherapie bei Patienten mit Schilddruesenautonomie und Morbus Basedow

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    Dederichs, B. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Koeln (Germany); Otte, R. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Koeln (Germany); Klink, J.E. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Koeln (Germany); Schicha, H. [Klinik und Poliklinik fuer Nuklearmedizin, Univ. Koeln (Germany)

    1996-10-01

    Aim: It is well known that radioiodine therapy (RITh) leads to a significant thyroid volume reduction (TVR). But until now only little data has been presented due to the course of time and the extent of TVR. Method: Therefore the data of 33 patients with Graves` disease (GD), 36 patients with multifocal (MAG) and 31 with solitary (SAG) autonomous goitre were analyzed retrospectively. Results: All the patients showed a highly significant (p<0.001) TVR, which continued up to 1 year after RITh. Receiving equal effective radiation doses, the extent of TVR was significantly greater for GD than for MAG. This difference developed within six weeks up to 3 months after RITh. Conclusion: This observation suggests that the underlying thyroid disease affects the therapeutic effect of RITh and may be partially explained by the total suppression of non-autonomous thyroid tissue in AG at the time of RITh. In patients with SAG with a 1.7 times higher effective radiation dose than in MAG relative TVR was about 1.6 times stronger in SAG than in MAG. This demonstrates a direct relation between the effective radiation dose and the extent of the TVR after RITh. (orig.) [Deutsch] Ziel: Es ist bekannt, dass die Radiojodtherapie (RJTh) zu einer relvanten Schilddruesenvolumenreduktion (SVR) fuehrt. Bisher wurden jedoch nur vereinzelt systematische Daten zum zeitlichen Verlauf und quantitativen Ausmass der SVR veroeffentlicht. Methode: Daher fuehrten wir eine retrospektive Auswertung der Daten von 33 Patienten mit Morbus Basedow (MB), 36 Patienten mit multifokaler (MFA) und 31 mit unifokaler (UFA) Autonomie der Schilddruese durch. Ergebnisse: Fuer alle Patientengruppen ergab sich eine hochsignifikante (p<0,001) SVR, welche sich bis ein Jahr nach RJTh signifikant fortsetzte. Obwohl die effektive Herddosis nicht signifikant verschieden war, war das Ausmass der SVR fuer Patienten mit MB signifikant groesser als fuer Patienten mit MFA. Dieser Unterschied war bereits innerhalb der ersten 6

  20. Ranking of CT in persistent vertigo after implantation of stapes prostheses; Stellenwert der Computertomographie bei persistierenden Gleichgewichtsstoerungen nach dem Einsatz von Stapesplastiken

    Energy Technology Data Exchange (ETDEWEB)

    Koesling, S. [Leipzig Univ. (Germany). Klinik fuer Diagnostische Radiologie; Woldag, K. [Leipzig Univ. (Germany). Klinik und Poliklinik fuer Hals-Nasen-Ohren-Krankheiten; Meister, E.F. [Leipzig Univ. (Germany). Klinik und Poliklinik fuer Hals-Nasen-Ohren-Krankheiten; Reschke, I. [Leipzig Univ. (Germany). Klinik fuer Diagnostische Radiologie; Schulz, H.G. [Leipzig Univ. (Germany). Klinik fuer Diagnostische Radiologie

    1995-01-01

    10 of 150 patients had persistent vertigo after implanation of stapes prostheses. These patients were evaluated by high resolution CT in the axial and coronal plane. Scans showed in all cases findings which related to the symptoms. The CT findings were proved intraoperatively in 9 cases. A new indirect sign of a perilymphatic fistula is described in form of an air bulla at the end of the prosthesis. Retympanotomy could be planned better with the help of HR-CT. (orig.) [Deutsch] Von 150 Patienten zeigten 10 nach dem Einsatz einer Stapesprothese eine persistierende vestibulaere Symptomatik. Mittels der hochaufloesenden Felsenbein-CT in axialer und koronarer Schnittfuehrung konnten in allen Faellen in Symptomatik erklaerende Befunde erhoben werden. Eine operative Bestaetigung erfolgte in 9 Faellen. Als bisher in der Literatur in diesem Zusammenhang nicht beschriebenes, indirektes Zeichen einer Perilymphfistel wurde eine kleine Luftblase am Prothesenende nachgewiesen. Die HR-CT hat sich als wesentliche Erleichterung bei der Planung einer Retympanotomie erwiesen. (orig.)

  1. Veno-occlusive liver disease after infradiaphragmatic total lymphoid irradiation. A rare complication; Die Venenverschlusskrankheit der Leber nach infradiaphragmaler total lymphatischer Bestrahlung. Eine seltene Nebenwirkung

    Energy Technology Data Exchange (ETDEWEB)

    Bischof, M.; Zierhut, D.; Gutwein, S.; Wannenmacher, M. [Heidelberg Univ. (DE.) Abt. fuer Klinische Radiologie - Schwerpunkt Strahlentherapie; Hansmann, J. [Heidelberg Univ. (DE.) Abt. fuer Radiologische Diagnostik; Stremmel, W.; Mueller, M. [Heidelberg Univ. (DE). Abt. Innere Medizin 4 (Schwerpunkt Gastroenterologie)

    2001-06-01

    -jaehrigen Patienten mit einem zentrozytisch-zentroblastischen Non-Hodgkin-Lymphom, Stadium IA (Lokalisation: Linke Leiste) wurde die gesamte Abdomen- und Beckenregion ('abdominelles Bad') bestrahlt. Bei einer woechentlichen Fraktionierung von fuenfmal 1,5 Gy wurde eine Gesamtdosis von 30 Gy appliziert. Zum Schutz der Risikoorgane wurden Nierenbloecke nach 13,5 Gy und Leberbloecke nach 25 Gy eingesetzt. Waehrend der letzten beiden Therapietage kam es zur Verschlechterung des Allgemeinzustandes des Patienten mit Gewichtszunahme, Vergroesserung des Bauchumfanges, Dyspnoe und einem Anstieg der Leberwerte. Die weiterfuehrende Diagnostik ergab eine Hepatosplenomegalie mit ausgepraegter Aszitesbildung und einen erhoehten portosystemischen Druckgradienten. Im Leberbiopsat wurde eine Venenverschlusskrankheit gefunden. Innerhalb 1 Woche nach Anlage eines transjungulaeren intrahepatischen portosystemischen Stent-Shunts (TIPSS), Vollheparinisierung und unter Diuretikagabe war der Patient beschwerdefrei. Die Leberwerte sind im Normbereich. Schlussfolgerung: Die Venenverschlusskrankheit der Leber (VOD) ist eine sehr seltene Nebenwirkung bei der abdominellen Bestrahlung nicht vorbehandelter follikulaerer Keimzentrumslymphome. Bei Oberbauchbeschwerden, Anstieg der Leberenzyme sowie Aszitesbildung, insbesondere in einem Zeitraum von bis zu 4 Monaten nach Therapieabschluss, muss an diese Komplikation gedacht werden. Genese, Diagnostik und Therapie der Venenverschlusskrankheit der Leber werden im Literaturueberblick praesentiert. (orig.)

  2. CFD calculation of a catalyst near the engine connected in series with an exhaust turbocharger; CFD-Berechnung fuer einen motornahen Katalysator nach Abgasturbolader

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, R.; Olesen, M. [Zeuna Staerker GmbH und Co. KG (Germany)

    2002-06-01

    Under the pressure of ever shorter development times and high demands on exhaust systems in terms of exhaust counterpressure, acoustic and sensory aspects and exhaust purification, Zeuna Staerker started at an early stage to use advanced CFD methods in their product development process. The contribution investigates the effects of simplified assumptions of boundary conditions, using laser optical flow measurements on a turbocharger with a catalyst near the engine. [German] Immer kuerzer werdende Entwicklungszeiten und die hohen Anforderungen an Abgasanlagen hinsichtlich Abgasgegendruck, Akustik, Sensorik und Abgasreinigung fuehrten bei Zeuna Staerker schon fruehzeitig zur Etablierung ausgereifter CFD-Methoden im Produktentwicklungsprozess. Doch wie stark werden CFD-Berechnungen durch die aufgepraegten Randbedingungen beeinflusst, wenn diese nach Abgasturbolader oft vereinfacht angenommen werden muessen? Mit Hilfe laseroptischer Stroemungsmessungen an einem Abgasturbolader mit motornahem Katalysator wird dieser Frage nachgegangen. (orig.)

  3. Auf in die Zukunft! Was kommt nach der bücherlosen Bibliothek? Reflexionen und Wahrnehmungsunterschiede zur Rolle von öffentlichen Bibliotheken

    Directory of Open Access Journals (Sweden)

    Wolfgang Kaiser

    2014-03-01

    Full Text Available Die Sehnsucht nach papierlosen und digitalen Bibliotheken ist auch in Deutschland weit verbreitet. Dabei entsteht der Irrglaube, die alleinige digitale Ausrichtung der eigenen Bibliothek mache diese zukunftsfähig. Ökonomisierungstendenzen, ein Mangel an Handeln nach ethischen Prinzipien, die ständige Messung von Ausleihen und Kunden sind das Spiegelbild des gegenwärtigen ideologischen Zeitgeistes. Im Artikel werden vermeintliche Glücksversprechen entlarvt und Alternativen aufgezeigt. Es wird für eine Öffnung hin zu anderen verwandten Disziplinen und der Förderung von mehr Vielfalt in der Ausbildung von Bibliothekaren und Bibliothekarinnen plädiert. Alternative Hinweise und Anregungen, welche für eine Neubewertung öffentlicher Bibliotheken eintreten, sind Teil des folgenden Beitrags. The longing for paperless and digital libraries is also very widespread in Germany as well as in other countries. At the same time there’s the misconception that the digital orientation might be the silver bullet for their institutions for a sustainable future. Tendencies of economization, the steady measurement of growth in library loans, and the notion and perception of clients and customers in libraries are a mirror image of our current ideological Zeitgeist. The article unmasks assumed promises of digitalization. It illustrates alternatives for the implementation of more democratic and participatory library policies. Furthermore the author pleads for an opening to other disciplines and the promotion of more diversity within the library field. Alternative leads and suggestions, which advocate a different evaluation of public libraries, are part of the following article.

  4. Use of recombinant, human TSH radioiodine therapy in patients with differentiated thyroid carcinoma; Radioiodtherapie des differenzierten Schilddruesenkarzinoms nach Vorbehandlung mit rekombinantem, humanem TSH

    Energy Technology Data Exchange (ETDEWEB)

    Luster, M. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2001-12-01

    Hypothyreose behandelt. Ein Patient litt neben einem papillaeren Schilddruesenkarzinom an einer sekundaeren Hypothyreose, ein Patient wurde wegen einer hypophysaeren Metastase und insuffizienter TSH-Produktion nach Radiatio ueberwiesen. Die Behandlung erfolgte nach einem standardisierten Regime: An 2 aufeinander folgenden Tagen wurden jeweils 0,9 mg rhTSH intramuskulaer verabreicht, gefolgt von der oralen Applikation von 1000-7000 MBq I-131 an Tag 3. Bei allen Patienten liess sich eine maximale TSH-Stimulation (>80 mU/l) erreichen, unerwuenschte Nebenwirkungen wurden nicht beobachtet. Im weiteren Verlauf kam es bei 7 Patienten zu einem deutlichen Abfall des Tg-Spiegels 1-4 Monate nach Therapie, 7 Patienten zeigten einen Progress der Erkrankung, hiervon verstarben 3, die in einem praefinalen Stadium behandelt worden waren, in einem Zeitraum von 1-3 Monaten. Zusammenfassend ist festzustellen, dass rekombinantes TSH ein hilfreiches Instrument bei der Behandlung dieses schwierigen Patientenkollektivs darstellt, dennoch kann die infauste Prognose einiger Patienten mit aggressivem Tumorwachstum nicht positiv beeinflusst werden. (orig.)

  5. Radiologic assessment of the outcome of Keller and Brandes arthroplasty for hallux rigidus; Hallux rigidus operiert nach Keller und Brandes: Radiologische Erfolgs- und Prognoseparameter

    Energy Technology Data Exchange (ETDEWEB)

    Breitenseher, M.J. [Abt. fuer Osteologie, Universitaetsklinik fueer Radiodiagnostik und Besondere Klinische Einrichtung Magnet Resonanz, Wien (Austria)]|[Ludwig-Boltzmann-Institut fuer Radiologische Tumordiagnostik, Wien (Austria); Toma, C.D. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Gottsauner-Wolf, F. [Universitaetsklinik fuer Orthopaedie, Wien (Austria); Imhof, H. [Abt. fuer Osteologie, Universitaetsklinik fueer Radiodiagnostik und Besondere Klinische Einrichtung Magnet Resonanz, Wien (Austria)]|[Ludwig-Boltzmann-Institut fuer Radiologische Tumordiagnostik, Wien (Austria)

    1996-06-01

    The aim of this study was to evaluate the pre- and postoperative radiographic findings of hallux rigidus treated with Keller and Brandes arthroplasty to determine the radiographic outcome and to identify a prognostic marker. 83 patients with a total of 121 cases of hallux rigidus operated using Keller and Brandes arthroplasty were followed up (mean 9.7 y). A comparison of the pre- and postoperative radiographs, the clinical and subjective findings was predicated on a five point scale: 1. Percentage of proximal phalanx resected (<33%, 33-50%, >50%), 2. joint space, 3. ratio of the length of the first and second metatarsals, 4. first intermetatarsal angle, and 5. hallux valgus angle. In the patient group which had 33-50% of the proximal phalanx excised (n=67. 55%) the highest patient satisfaction was observed (96%). If resection of the proximal phalanx exceeded 50% (n=13. 11%), non physiologic dorsiflexion of the toe occurred and patients were unsatisfied (62%). Excision of less than 33% of the hallux (n=41. 34%) was associated with a recurrent hallux rigidus. No other evaluated radiological parameter proved to be of significance. The most important radiological parameter in the evaluation of the outcome of Keller and Brandes arthroplasty as the percentage of the proximal phalanx which had ben excised. (orig.) [Deutsch] Ziel der Studie war es, auf prae- und postoperativen Roentgenbildern des Hallux rigidus radiologische Parameter zu ermitteln, die den Erfolg der Arthroplastik nach Keller und Brandes abschaetzen und von prognostischer Relevanz sind. 121 Hallux-rigidus-Operationen bei 83 Patienten wurden nachuntersucht (9,7 a). 5 Kriterien wurden an den prae- und postoperativen Roentgenbildern ausgewertet: 1. Anteil der Grosszehengrundgliedresektion in Prozent (<33%, 33-50%, >50%), 2. Gelenkspaltbreite, 3. Laengenverhaeltnis von erstem und zweitem Metartasalknochen, 4. erster Intermetatarsalwinkel und 5. Hallux-valgus-Winkel und mit den klinischen Ergebnissen

  6. Zur Durchführbarkeit eines regelmäßigen Trainings mit der Nintendo Wii Fit Plus bei Frauen nach der Schwangerschaft

    Directory of Open Access Journals (Sweden)

    Nitzsche N

    2011-01-01

    Full Text Available Sport im Sinne eines regelmäßigen körperlichen Trainings sollte aus gesundheitlichen Gründen nach einer Schwangerschaft empfohlen werden. Jedoch müssen an diese Aktivitäten besondere Ansprüche gestellt werden. Die Beanspruchung sollte moderat und mit geringem Risiko sein. Weiters muss die körperliche Aktivität in den Tagesablauf einer jungen Mutter integrierbar sein. Hierzu könnten digitale Spiele mit Ganzkörperaktivitäten sinnvoll eingesetzt werden. Ziel dieser Trainingsstudie war es, möglichen Einsatz und mögliche Wirkung ausgewählter Übungen der Nintendo Wii Fit Plus bei postnatalen Frauen zu überprüfen. Dabei wurden subjektive Eindrücke wie das Spielerleben und wahrgenommene Beanspruchung erhoben. Die Wirkung auf die aerobe Ausdauerleistungsfähigkeit wurde durch eine 6-wöchige Intervention überprüft. An der Studie nahmen 8 Probandinnen (Alter 29,0 ± 4,6 Jahre, Größe 1,7 ± 0,1 m, Body-Mass-Index [BMI] 25,1 ± 3,1 kg/m², postnatal 6,3 ± 1,9 Wochen teil. Ergebnisse: Die Probandinnen zeigten nach einmaligem Spielen eine hohe bis sehr hohe Motivation, dieses Spiel noch mal zu spielen. Es wurde als nicht stressig mit mittlerer Spielgeschwindigkeit bei einfacher und übersichtlicher Bedienung bewertet. Über den Beobachtungszeitraum nahmen die Frauen eine moderate (etwas anstrengende Beanspruchung mit hohem Spaßempfinden wahr. Signifikante Gewichtsreduktionen sowie eine Verbesserung der aeroben Leistungsfähigkeit konnten nicht festgestellt werden. Schlussfolgernd bleibt festzuhalten, dass trotz nicht-signifikanter metabolischer und morphologischer Adaptionen eine hohe Motivation zu erwarten ist, was unter gegebenen Übungsvariationen der Nindento Wii Fit Plus zu regelmäßigem Training führen kann. Da diese Studie nur Pilotcharakter hatte, wäre unter randomisierten kontrollierten Bedingungen eine Untersuchung mit größerem Probandenumfang durchzuführen.

  7. Beijing Bubble, Beijing Bust: Inequality, Trade, and Capital Inflow into China Beijing Blase, Beijing Krise: Ungleichheit, Handel und Kapitalzufluss nach China

    Directory of Open Access Journals (Sweden)

    James K. Galbraith

    2009-07-01

    Full Text Available This paper explores the relationships between inequality, trade, and capital flows into China since the early 1990s and particularly in the first years of the present decade. We show that the rise in economic inequality in China has more to do directly with the activities associated with China’s financial and building boom, notably in Beijing, than with the massive growth in manufacturing employment and in Chinese exports since China joined the WTO in 2001. Nevertheless, it is likely that a flow of profits from the export boom did feed the speculative fires in the capital and elsewhere, and therefore it should be no surprise that the fall of one should be linked to the fall of the other, in a particularly painful reduction of economic inequality. In diesem Artikel werden die Beziehungen zwischen Ungleichheit, Handel und Kapitalzufluss nach China seit den frühen 1990er Jahren untersucht. Es wird aufgezeigt, dass die steigende wirtschaftliche Ungleichheit in China weit mehr mit Chinas Finanz- und Bauboom insbesondere in Beijing zu tun hat als mit dem großen Anstieg der Beschäftigung in der Produktion und in Chinas Exporten seit dem WTO-Beitritt im Jahr 2001.

  8. Supplement Analysis for the Watershed Management Program EIS (DOE/EIS-0265/SA-90) - Naches River Water Treatment Plant Intake Screening Project

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Shannon C. [Bonneville Power Administration (BPA), Portland, OR (United States)

    2002-09-26

    BPA is proposing to fund the upgrade of the intake structure for the City of Yakima’s Water Treatment Plant. The existing traveling water screen at the intake does not achieve the current fish screening criteria as defined by Washington State Law and as provided in guidance from the National Marine Fisheries Service. Permanent modifications to the intake system including installation of a fish screen and bypass system are necessary to eliminate mortality and take of ESA listed and non-listed salmonids, as well as resident fish at this location. This project will include: modifications to bypass the existing intake system; the construction of a new intake structure with approved fish screens; installation of a 48-inch diameter pipeline connecting the new intake to the existing intake structure; a reduced intake channel separating PacifiCorp Powerhouse return water/ Naches River water from the irrigation and Wapatox waste ditch return water; modifications to the auxiliary headgates; increased height on the upstream end of the channel wall; and a new outfall structure with plunge pool and upstream migrant barriers.

  9. Alar ligaments: radiological aspects in the diagnosis of patients with whiplash injuries; Stellenwert bildgebender Verfahren in der Diagnostik der Ligg. alaria nach Beschleunigungsverletzung der Halswirbelsaeule

    Energy Technology Data Exchange (ETDEWEB)

    Muhle, C. [Klinik fuer Nuklearmedizin, Christian-Albrechts-Univ. zu Kiel (Germany); Brossmann, J.; Biederer, J.; Jahnke, Th.; Grimm, J.; Heller, M. [Klinik fuer Diagnostische Radiologie, Christian-Albrechts-Univ. zu Kiel (Germany)

    2002-04-01

    Post-traumatic changes of the alar ligaments have been proposed to be the cause of chronic pain in patients after whiplash injury of the cervical spine. In addition to an asymmetric dens position, widening of the atlantodental distance to more than 12 mm can be an indirect sign of an alar ligament rupture. CT is recommended for detection of a avulsion fracture of the occipital condyle. Isolated ruptures of the alar ligaments are best visualized on MRI. In patients with chronic impairments after whiplash injuries changes of the alar ligaments on MRI must be differentiated from normal variants in healthy individuals. (orig.) [German] Posttraumatische Veraenderungen der Ligg. alaria werden als ursaechlich fuer chronische Beschwerden bei Patienten mit Beschleunigungsverletzungen der Halswirbelsaeule angesehen. Eine asymmetrische Densposition sowie eine Erweiterung der anterioren atlantoaxialen Distanz auf ueber 12 mm koennen auf konventionellen Roentgenaufnahmen ein indirektes Zeichen fuer das Vorliegen einer Fluegelbandverletzung sein. Die Computertomographie ist die Methode der Wahl zum Nachweis einer kondylaeren Ausrissfraktur des Lig. alare. Isolierte akute Bandverletzungen der Ligg. alaria sind hingegen in der MRT direkt nachweisbar. Bei Patienten mit chronischen Beschwerden nach Beschleunigungsverletzungen der Halswirbelsaeule muessen allerdings morphologische Auffaelligkeiten der Ligg. alaria im MRT von Normvarianten abgegrenzt werden. (orig.)

  10. Mycotic aneurysm of the superior mesenteric artery after septic embolism; Entwicklung eines mykotischen Aneurysmas der A. mesenterica superior nach septischer Embolie

    Energy Technology Data Exchange (ETDEWEB)

    Schmidt, F.; Dinkel, H.P. [Institut fuer Diagnostische Radiologie, Inselspital, Universitaetsklinik Bern (Switzerland)

    2002-07-01

    Mycotic aneurysms of the aorta and the visceral arteries are life-threatening diseases, due to potential rupture and organ or limb ischemia. They occur in endocarditis, immunodeficiency, bacteremia and fungemia, and have a poor prognosis.We report on a case of a 54-year-old male patient suffering from abdominal angina after mitral valve replacement for septic mycotic endocarditis. In presence of a mycotic-embolic occlusion of the left popliteal artery and multiple septic organ infarctions a mycotic aneurysm of the superior mesenteric artery was found in abdominal spiral-CT.Based on sequential spiral-CT examinations, this case demonstrates the development of a septic aneurysm of the superior mesenteric artery. (orig.) [German] Mykotische Aneurysmen der Aorta und ihrer Aeste stellen wegen Rupturgefahr und moeglicher Minderperfusion von Organen und Extremitaeten eine lebensgefaehrliche Erkrankung mit unguenstiger Prognose dar. Beguenstigende Faktoren sind geschwaechte Immunabwehr, Endokarditis, Bakteriaemie und Fungaemie.Wir berichten ueber einen 54-jaehrigen Patienten, der nach einem Mitralklappenersatz bei mykotischer Endokarditis zunehmende abdominelle Beschwerden im Sinne einer Angina abdominalis entwickelte. Die abdominelle Spiralcomputertomographie zeigte ein mykotisches Aneurysma der A. mesenterica superior. Daneben bestanden ein mykotischer Verschluss der linken A. poplitea und multiple septische Organinfarkte.Der Fall demonstriert anhand sequentieller Computertomographien eindrucksvoll die Entwicklung eines septischen Viszeralarterienaneurysmas. (orig.)

  11. Early alterations in the hip joint following epiphysiolysis for slipped femoral head. Results of an MRI study; Fruehveraenderugen im Hueftgelenk nach Epiphysiolysis capitis femoris. MRT-Untersuchungsergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Stoever, B. [Freiburg Univ. (Germany). Radiologische Klinik; Sigmund, G. [Freiburg Univ. (Germany). Radiologische Klinik; Huhle, P. [Freiburg Univ. (Germany). Orthopaedische Abteilung; Zwack, P. [Freiburg Univ. (Germany). Orthopaedische Abteilung; Reichert, A. [Freiburg Univ. (Germany). Orthopaedische Abteilung; Langer, M. [Freiburg Univ. (Germany). Radiologische Klinik

    1994-01-01

    With the aim of detecting patients at risk of developing coxarthritis, 34 patients were investigated prospectively by MRI 6-14 years after epiphysiolysis for slipped capital femoral head. In particular, cartilage changes were analysed by gradient-echo sequences. In 40% of the hip joints investigated cartilaginous lesions were present, detectable as irregularity and flattening of contour and more rarely as changes in signal intensity. In contrast, only 18% of the radiographs available revealed any pathology. When pelvic X-rays are normal or reveal slight sclerosis, cartilaginous lesions on MRI are considered early signs of coxarthrosis. This combination was seen especially often in patients with a primarily high angle of dislocation and in those who needed treatment by reposition or osteotomy. Only in 8 of the 17 hip joints showing sclerosis on conventional radiograms, sclerosis was also diagnosed by MRI, possibly because of partial volume and susceptibility effects at high field strength. Even with limited spatial resolution, cartilage examinations is warranted in young patients in whom early osteoarthritis can be expected. (orig.) [Deutsch] Mit dem Ziel, Veraenderungen am Hueftgelenk bei Patienten mit Arthroserisiko rechtzeitig zu erfassen, wurden 34 Patienten 6-14 Jahre nach einer Epiphysiolysis capitis femoris mittels MRT im Hochfeld bei 2/T nachuntersucht. Insbesondere sollten anhand der `FLASH`-Gradientenechosequenzen Knorpelveraenderungen analysiert werden. In 40% der untersuchten Hueftgelenke lagen Knorpellaesionen vor, sichtbar als Verduennung der Knorpelschicht, Konturunregelmaessigkeit und seltener als Signalintensitaetsveraenderungen. Dagegen waren nur 18% der vorhandenen Roentgenbefunde eindeutig pathologisch. Die kernspintomographisch sichtbaren Laesionen des Knorpels sind bei normalem Roentgenbild als Fruehveraenderungen zu werten und waren haeufiger bei Patienten mit primaer hohem Dislokationswinkel nachweisbar wie auch bei Patienten, bei denen eine

  12. Ecotoxicological and human toxicological risk assessment of PAH-contaminated soils before and after biological treatment; Oekotoxikologische und humantoxikologische Risikobewertung PAK-belasteter Boeden vor und nach biologischer Behandlung

    Energy Technology Data Exchange (ETDEWEB)

    Roos, P.H.; Hanstein, W.G. [Bochum Univ. (Germany). Inst. fuer Physiologische Chemie; Weissenfels, W.D. [RAG Umwelt Kommunal GmbH, Bottrop (Germany); Afferden, M. van [IMTA, Jiutepec, Mor. (Mexico); Pfeifer, F. [DMT-Gesellschaft fuer Forschung und Pruefung mbH, Essen (Germany)

    2000-07-01

    The goal of the present work is to assess the adverse effects of soil bound polycyclic aromatic hydrocarbons (PAH) which remain in soils after biological remediation. We focus on risk assessment for mammalian species with respect to the oral uptake of contaminated soil particles and compare the results of a biomarker test with those of an ecotoxicological assay, the bioluminescence inhibition test with Vibrio fischeri. As a biomarker effect in mammals, we determined the liver microsomal cytochrome P450 enzyme CYP1A1 which is induced by PAH in exposed rats. After biological soil treatment, different amounts of PAH remain in the soil depending on the soil properties and initial pollutant composition. Particularly, higher condensated PAH resists biological treatment due to its hydrophobicity. In addition, high amounts of organic carbon in the soils affect remediation efficiency. In the bioluminescence inhibition test, eluates of all biologically treated soils studied do not reveal any or only low inhibitory effects. In contrast, the oral uptake of biologically treated contaminated soils leads to induction levels for CYP1A1 similar to those in the untreated samples. A good correlation is obtained between CYP1A1 levels and the amount of 5 and 6-ring PAH in the soil samples. The main result is that the remediation efficiency determined by the luminescence test is not reflected by the biomarker test, a finding which indicates the high bioavailability of residual PAH in soils. Consequently, new criteria for human risk assessment can be delineated. (orig.) [German] Ziel dieser Arbeit ist es, moegliche toxische Wirkungen PAK-belasteter Boeden vor und nach biologischer Sanierung zu erfassen. Hierbei liegt der Schwerpunkt auf der Abschaetzung des Risikos fuer Saeugetiere nach oraler Aufnahme von Bodenpartikeln. Als Biomarker-Effekt fuer die PAK-Aufnahme haben wir in Ratten die Induktion des lebermikrosomalen P450-Enzyms CYP1A1 bestimmt, dessen Expression durch PAK moduliert

  13. Kardiovaskuläres Risikofaktorenprofil und Herzinfarktrisiko nach dem PROCAM-Index bei Männern mittleren Alters unter besonderer Berücksichtigung der EKG-Veränderungen unter Belastungsbedingungen

    OpenAIRE

    Kirchhof, M.R. (Monika)

    2006-01-01

    An 1248 Soldaten, wurde das kardiovaskuläre Risikofaktorenprofil bestimmt und das Herzinfarktrisiko nach dem PROCAM-Index ermittelt. Häufigkeit der Risikofaktoren: BMI?25kg/m2: 68,8%, positive Familienanamnese für Herzinfarkt 13,4%, Zigarettenrauchen 17,9%, körperliche Inaktivität 4,9%, systolischer RR?140mmHg: 50,9%, diastolischer RR?90mmHg: 41,4%, Gesamtcholesterin?5,2 mmol/l: 59,7%, HDL-Cholesterin?1,2 mmol/l: 33,5%, Gesamtcholesterin/HDL-Cholesterin-Quotient?4: 52,3%, LDL-Cholesterin ?4,...

  14. [Annemarie Stiedl. Auf nach Wien! Die mobilität des mitteleuropäischen Handwerks im 18. und 19. Jahrhundert am Beispiel der Haupt- und Residenzstadt] / Raimo Pullat

    Index Scriptorium Estoniae

    Pullat, Raimo, 1935-

    2009-01-01

    Arvustus: Stiedl, Annemarie. Auf nach Wien! Die mobilität des mitteleuropäischen Handwerks im 18. und 19. Jahrhundert am Beispiel der Haupt- und Residenzstadt. Sozail- und wirtschaftshistorische Studien. Bd. 30. Wien, 2003. Teose põhisisu moodustab 18. ja 19. sajandi linnakäsitööliste rände ruumiliste muutuste ja nihete jälgimine. Autor on võtnud vaatluse alla peamiselt neli käsitööametit : lihunikud, korstnapühkijad, siidist asjakeste valmistajad ning nahast kottide ja mappide valmistajad

  15. Long-term follow up MRI in children with severe head injury; Kernspintomographische Verlaufskontrolle bei Kindern nach Schaedel-Hirn-Trauma

    Energy Technology Data Exchange (ETDEWEB)

    Dinter, D.; Schmidt, B.; Neff, K.W.; Georgi, M. [Heidelberg Univ., Mannheim (Germany). Fakultaet fuer Klinische Medizin; Koelfen, W. [Elisabeth-Krankenhaus, Rheydt (Germany). Paediatrische Klinik; Freund, M.C. [Universitaetsklinik fuer Radiodiagnostik, Innsbruck (Austria)

    1999-10-01

    Purpose: A prospective study was initiated for the correlation of the findings in the initial cranial CT with the long-term follow-up MRI in children with severe head injury. Another aim was the evaluation of frequency and location of lesions, found only in MRI. Methods: 70 children with severe head injury and initially performed pathological CCT were followed up (mean time 3 years) by MRI. Results: 71% of the children had a pathological MRI. In 43% of the children with subdural bleeding could be found parenchymal lesions in the underlying cortex. All 15 children with epidural bleeding had unsuspicious findings at the former hematoma. All of the contusions were found as parenchymal residual lesions. 44% of the children had evidence of parenchymal lesions in the follow-up MRI initially and retrospectively not revealable. 16 lesions in the corpus callosum were only revealed by MRI. Conclusion: This study shows the higher sensitivity of magnetic resonance imaging in non-hemorrhagic parenchymal lesions and in 'diffuse axonal injury'. A MRI-examination is recommended in children with severe head injury, especially in patients with normal CCT and posttraumatic neurological deficits. (orig.) [German] Fragestellung: Im Rahmen einer prospektiven Studie wurden die Befunde initial durchgefuehrter Computertomographien bei Kindern mit schwerem SHT mit den Ergebnissen einer MR-Nachuntersuchung korreliert und zusaetzlich eine Evaluation der Haeufigkeit und Lokalisation ausschliesslich kernspintomographisch nachweisbarer Laesionen durchgefuehrt. Methodik: 70 Kinder mit initial nach SHT durchgefuehrtem und pathologischem CT wurden im Rahmen eines Follow-up im zeitlichen Abstand von durchschnittlich 3 Jahren kernspintomographisch nachuntersucht. Ergebnisse: Bei 71% der nachuntersuchten Kinder konnten pathologische MRT-Befunde erhoben werden. 43% der Kinder mit einer subduralen Blutung wiesen kortikal, der ehemaligen Blutung anliegende, Parenchymlaesionen auf, dagegen

  16. Follow-up radiographs of the cervical spine after anterior fusion with titanium intervertebral disc; Roentgen-Verlaufsuntersuchung der Halswirbelsaeule nach anteriorer Fusion mit Titaninterponaten

    Energy Technology Data Exchange (ETDEWEB)

    Biederer, J; Hutzelmann, A; Heller, M [Kiel Univ. (Germany). Klinik fuer Diagnostische Radiologie; Rama, B [Paracelsus Klinik, Osnabrueck (Germany). Klinik fuer Neurochirurgie

    1999-08-01

    Purpose: We examined the postoperative changes of the cervical spine after treatment of cervical nerve root compression with anterior cervical discectomy and fusion with a new titanium intervertebral disc. Patients and Methods: 37 patients were examined prior to, as well as 4 days, 6 weeks, and 7 months after surgery. Lateral view X-rays and functional imaging were used to evaluate posture and mobility of the cervical spine, the position of the implants, and the reactions of adjacent bone structures. Results: Implantation of the titanium disc led to post-operative distraction of the intervertebral space and slight lordosis. Within the first 6 months a slight loss of distraction and re-kyphosis due to impression of the implants into the vertebral end-plates were found in all patients. We noted partial infractions into the vertebral end-plates in 10/42 segments and slight mobility of the implants in 14/42 segments. Both groups of patients showed reactive spondylosis and local symptoms due to loosening of the implants. The pain subsided after onset of bone bridging and stable fixation of the loosened discs. Conclusions: The titanium intervertebral disc provides initial distraction of the fusioned segments with partial recurrence of kyphosis during the subsequent course. Loosening of the implants with local symptoms can be evaluated with follow-up X-rays and functional imaging. (orig.) [German] Ziel: An Patienten mit zervikalen Kompressionssyndromen wurden Stellung und Funktion der Halswirbelsaeule nach Diskektomie und Fusion mit einem neuartigen Titaninterponat untersucht. Patienten und Methoden: Bei 37 Patienten (42 Segmente) wurden praeoperativ sowie 4 Tage, 6 Wochen und 7 Monate postoperativ mit seitlichen Uebersichts- und Funktionsaufnahmen Stellung und Mobilitaet der HWS beurteilt. Erfasst wurden Lageveraenderungen des Titaninterponates und die Reaktion der angrenzenden Wirbelkoerperabschlussplatten. Ergebnisse: Das Titaninterponat bewirkte postoperativ eine

  17. Diagnosis and therapy of dysfunctions of human leukocytes after irradiation. Final report; Diagnose und Therapie von Funktionsstoerungen menschlicher Leukozyten nach Bestrahlung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Beuningen, D. van; Kaffenberger, W. [Sanitaetsakademie der Bundeswehr, Muenchen (Germany); Baaske, C.; Leipert, D.

    1999-08-01

    Immunkomplexe bzw. Phorbolester) aktiviert die NADPH-Oxidase auf parallel verlaufenden Signaltransduktionskaskaden, die in einer Aktivierung von Proteinkinase C-Isoenzymen zusammenlaufen. Einzelne Enzyme der Kaskaden wurden mittels pharmakologischer Inhibitoren in Verbindung mit dem 'Western'-Verfahren identifiziert, Lipid-'2{sup nd}-messenger' durch HPLC-Analyse. Die Daten weisen auf ein aeusserst komplexes System mit Quervernetzungen, Rueckkopplungen und Parallelschaltungen bei der Aktivierung der NADPH-Oxidase hin. Sie identifizieren erstmals mehrere zytoplasmatische/membranstaendige Elemente von Signaltransduktionskaskaden als strahlenempfindlich, die eine moegliche Basis fuer kausal-orientierte Therapieansaetze und eine Erklaerung fuer Immundefekte nach Bestrahlung bieten. (orig.)

  18. Modified double contrast-enhanced examination of the stomach of adipose patients after vertical gastroplasty; Modifizierte Doppelkontrast-Untersuchung des Magens bei adipoesen Patienten nach vertikaler Gastroplastie

    Energy Technology Data Exchange (ETDEWEB)

    Raissaki, M.T. [Institut fuer Bildgebende Diagnostik, Universitaetsklinik Heraklion (Greece); Prassopoulos, P. [Institut fuer Bildgebende Diagnostik, Universitaetsklinik Heraklion (Greece); Hatjidakis, A.A. [Institut fuer Bildgebende Diagnostik, Universitaetsklinik Heraklion (Greece); Christodoulakis, M. [Klinik fuer Chirurgische Onkologie der Universitaetsklinik Heraklion (Greece); Melissas, J. [Klinik fuer Chirurgische Onkologie der Universitaetsklinik Heraklion (Greece); Gourtsoyiannis, N.C. [Institut fuer Bildgebende Diagnostik, Universitaetsklinik Heraklion (Greece)

    1995-11-01

    The study reported covers 28 patients who were examined once by radiology before surgery, and twice after surgery. The first post-surgery examination was done on days 5-7, the second during the 4th until 6th month after surgery. For the first examination, water-soluble contrast agent was initially applied, then barium containing contrast agent. The second examination was done by modified double contrast technique. The most frequent, pre-surgery findings revealed gastro-esophageal reflux in 13 patients. The first post-surgery control detected a somastenosis in 2 patients, while the second control examination detected complications of various nature in 11 patients and gastro-esophageal reflux in 5 patients. In 6 patients, discrepancy between clinical and radiological findings was stated. The pouch size did not correlate with the frequency of complications, or with the body-to-mass index decrease. The examination method proposed in this article yields pre-surgery information on the anatomy of the stomach, more accurate dewscription of post-surgery complications, and better evaluation of the antireflux effect of the vertical gastroplasty. (orig.) [Deutsch] In der Studie wurden 28 Patienten einmal praeoperativ und zweimal postoperativ roentgenologisch kontrolliert. Die erste postoperative Kontrolle fand am 5.-7. Tag und die zweite im 4.-6. Monat nach dem Eingriff statt. Bei der ersten Kontrolle wurde zuerst wasserloesliches und anschliessend bariumhaltiges Kontrastmittel benutzt, waehrend bei der zweiten Kontrolle eine modifizierte Doppelkontrast-Untersuchung durchgefuehrt wurde. Der haeufigste praeoperative Befund war der gastrooesophageale Reflux bei 13 Patienten. Bei der ersten praeoperativen Kontrolle fand sich bei 2 Patienten eine Stomastenose, waehrend bei der zweiten verschiedene Komplikationen bei 11 sowie gastrooesophagealer Reflux bei 5 Patienten vorlagen. Eine Diskrepanz zwischen radiologischen und klinischen Befunden fanden wir bei 6 Patienten. Die

  19. Global CO{sub 2} emissions 2015. Trend reversion is still waiting, despite hopeful approaches; Weltweite CO{sub 2}-Emissionen 2015. Trendwende laesst trotz hoffnungsvoller Ansaetze nach wie vor auf sich warten

    Energy Technology Data Exchange (ETDEWEB)

    Ziesing, Hans-Joachim

    2016-10-15

    By 2015, global CO{sub 2} emissions were virtually unchanged from 2014 according to provisional calculations. On the whole, a slight increase may have resulted, which has slowed the growth of the past few years. In the previous year alone, the weakest growth since the beginning of the century had been recorded, with only 0.7% of the upturn (with the exception of the crises in 2008/2009). As a result, CO{sub 2} emissions in 2015 were only slightly higher than in the previous year, at 33.1 billion tonnes. A global trend reversal is still likely, but the CO{sub 2} emissions have declined in many countries, particularly in some industrialized countries. [German] Im Jahr 2015 haben sich die weltweiten CO{sub 2}-Emissionen nach vorlaeufigen Berechnungen gegenueber 2014 praktisch nicht veraendert. Insgesamt duerfte sich allenfalls ein leichtes Plus ergeben haben, womit der Zuwachs der vergangenen Jahre erneut gebremst wurde. Schon im Vorjahr war mit einem Plus von nur 0,7 % der bis dahin (mit Ausnahme der Krisenjahre 2008/2009) schwaechste Anstieg seit Beginn des Jahrhunderts zu verzeichnen gewesen. Im Ergebnis blieben die CO{sub 2}-Emissionen 2015 mit reichlich 33,1 Mrd. t nur geringfuegig ueber dem Niveau des Vorjahres. Eine weltweite Trendwende steht wohl noch nach wie vor aus, doch sind immerhin die CO{sub 2}-Emissionen in zahlreichen Laendern, insbesondere in etlichen Industrielaendern, gesunken.

  20. Facilities granted by the authorities to companies certified in accordance with the EC Eco-Audit Ordinance; Behoerdliche Erleichterungen fuer validierte Unternehmen nach der EG-Oeko-Audit-Verordnung

    Energy Technology Data Exchange (ETDEWEB)

    Funda, K. [Witzenhausen-Institut fuer Abfall, Umwelt und Energie, Witzenhausen (Germany)

    1999-07-01

    During the past few years there has been a growing discussion on possible ways of granting facilities and allowing simplified legal procedures for companies which have been certified according to the EU Eco-Audit Regulation and which have thus submitted themselves voluntarily to the requirements of this code. This paper gives an account of the current stage of the discussion and describes the facilities currently granted by the German federal states to certified companies. It is largely based on the relevant regulations and decrees issued by the federal states as chief enactors of environmental law and on information given orally and in writing by the various ministries involved in the data search carried out between January and March 1999. [German] In den letzten Jahren wurde zunehmend die Frage nach ordnungsrechtlichen Erleichterungen und Vereinfachungen fuer Unternehmen diskutiert, die eine Validierung nach der EG-Oeko-Audit-Verordnung durchgefuehrt und sich damit freiwillig den Anforderungen dieses Regelwerkes unterworfen haben. Der vorliegende Beitrag versucht den aktuellen Stand dieser Diskussion zu beleuchten und die zur Zeit von den Bundeslaendern eingeraeumten Erleichterungen fuer Unternehmen darzustellen. Grundlage der Aussagen sind im wesentlichen die einschlaegigen Vorschriften und Erlasse der Laender, in deren Hand zum groessten Teil der Vollzug des Umweltrechtes liegt, sowie muendliche und schriftliche Informationen aus den verschiedenen Fachministerien, die im Rahmen einer Datenrecherche zwischen Januar und Maerz 1999 zusammengetragen wurden. (orig.)

  1. The Prevalence of Power-Sharing: Exploring the Patterns of Post-Election Peace Die Verbreitung von Power-Sharing: Bedingungen für eine friedliche Entwicklung nach Wahlen

    Directory of Open Access Journals (Sweden)

    Anna K. Jarstad

    2009-01-01

    Full Text Available Why are some elections followed by armed conflict, while others are not? This article begins to explore this question by mapping the prevalence of power-sharing agreements and patterns of post-election peace in states shattered by civil war. While democracy builds on the notion of free political competition and uncertain electoral outcomes, power-sharing reduces the uncertainty by ensuring political power for certain groups. Nevertheless, new data presented in this article – the Post-Accord Elections (PAE data collection – shows that the issues of peace, power-sharing and democracy have become intertwined as the vast majority of contemporary peace agreements provide for both power-sharing and elections. First, in contrast to previous research which has suggested that power-sharing is a tool for ending violence, this study shows that conflict often continues after an agreement has been signed, even if it includes provisions for power-sharing. Second, this investigation shows no evidence of power-sharing facilitating the holding of elections. On the contrary, it is more common that elections are held following a peace process without power-sharing. Third, a period of power-sharing ahead of the elections does not seem to provide for postelection peace. Rather, such elections are similarly dangerous as post-accord elections held without a period of power-sharing. The good news is that power-sharing does not seem to have a negative effect on post-election peace. Warum folgt auf Wahlen in manchen Fällen ein bewaffneter Konflikt, in anderen nicht? Die Autorin nähert sich der Antwort auf diese Frage, indem sie die Verteilung von Machtteilungsabkommen und Friedensbedingungen nach Wahlen in Bürgerkriegsstaaten untersucht. Während Demokratie auf der Vorstellung freien politischen Wettbewerbs und offener Wahlergebnisse basiert, reduziert Power-Sharing (Machtteilung diese Offenheit, indem bestimmten Gruppen politische Macht zugesichert wird. Aktuelle

  2. Vorrichtung nach Art eines Knickarmroboters

    OpenAIRE

    Wanner, Martin Christoph; Dryba, Steffen; Wollenberg, Michael; Kny, Reinhart

    2015-01-01

    The invention relates to an articulated arm robot-type device for handling a payload, comprising a robot arm (R), which is attached to a base (1) that can be rotated about a first axis (A1), and at least two arm elements (2, 3), which are arranged one behind the other in the form of a kinematic chain and a first arm element (2) of which is mounted on the base (1) in a pivotal manner about a second axis (A2) that is oriented orthogonally relative to the first axis and a second arm element (3) ...

  3. Die Jagd nach dem Allerkleinsten

    CERN Multimedia

    Wolter, Uwe

    2006-01-01

    Only with probes and telescopes scientists do not explore the universe. To understand the processes in the cosmos, researchers feign Big Bang in gigantic devices and look with extremely sensitive detectors for the most elementary particles (1 page)

  4. Die Suche nach den Gottesteilchen

    CERN Multimedia

    2007-01-01

    2008 wird der größte jemals gebaute Teilchenbeschleuniger in Betrieb genommen Anlässlich des Mathematik-Jahres 2008 hat der Experimentalphysiker der Universität Hamburg und der designierte Generaldirektor des europäischen Zentrums für Teilchenphysik CERN in Genf, Rolf-Dieter Heuer, die Bedeutung des Dialogs zwischen Naturwissenschaftlern und Philosophen hervorgehoben.

  5. Intraindividual comparison of gastric peristalsis after ingestion of a semiliquid and solid test meal; Intraindividueller Vergleich der Magenperistaltik nach Gabe von semiliquiden und festen Testmahlzeiten

    Energy Technology Data Exchange (ETDEWEB)

    Linke, R. [Muenchen Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Tatsch, K. [Muenchen Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Muenzing, W. [Muenchen Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin; Vorderholzer, W. [Muenchen Univ. (Germany). Medizinische Klinik Innenstadt; Schindlbeck, N. [Muenchen Univ. (Germany). Medizinische Klinik Innenstadt; Hahn, K. [Muenchen Univ. (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    1997-06-01

    Aim: Patients with various disorders of gastric function were studied with radiolabeled test meals of different consistency to elaborate the effect of ingested media on gastric peristalsis and emptying. Methods: In 12 patients parameters of gastric function were intraindividually compared after ingestion of a semiliquid and a solid test meal. In addition to the standard evaluation derived from time activity curves condensed images were established from two fixed time intervals (early and late period). These images were used to evaluate the amplitude and frequency of gastric contractions using Fourier analysis. Results: As expected gastric emptying was influenced by the consistency of the test meal. Mean emptying rates for the solid meal were significant lower than those for the semiliquid one (p<0,01). The amplitude and frequency of gastric contractions, however, did not depend on the consistency of the test meal. Within the course of the examination contraction amplitudes significantly increased (p<0,05) from the early to the late period using both, solid as well as semiliquid test meals. The frequency of gastric contractions remained unchanged. Conclusion: As shown by an intraindividual data comparison amplitude and frequency of gastric contractions seem to be independent of the consistency of ingested test meals whereas gastric emptying is significantly influenced by the administered media. Semiliquid meals offer advantages with respect to the shorter examination time and simpler preparation and therefore may be preferred for routine use. Since amplitudes seem to vary within the observation period standardized acquisition protocols are recommended for the evaluation of this parameter. (orig.) [Deutsch] Ziel: An einem heterogenen Kollektiv von Patienten mit gastrointestinalen Beschwerden wurde der Einfluss von Testspeisen unterschiedlicher Konsistenz auf Peristaltik und Entleerungsrate des Magens untersucht. Methodik: Bei 12 Patienten wurde nach Gabe von

  6. Verwendung von Kabeln und isolierten Leitungen für Fernmeldeanlagen und Informationsverarbeitungsanlagen; Besondere Richtlinien für Leitungen mit Litzenleitern für erhöhte mechanische Beanspruchung für Fernmeldeanlagen und Informationsverarbeitungsanlagen nach DIN 57817/VDE 0817 [VDE-Richtlinie

    CERN Document Server

    Deutsches Institut für Normung. Berlin

    1984-01-01

    Verwendung von Kabeln und isolierten Leitungen für Fernmeldeanlagen und Informationsverarbeitungsanlagen; Besondere Richtlinien für Leitungen mit Litzenleitern für erhöhte mechanische Beanspruchung für Fernmeldeanlagen und Informationsverarbeitungsanlagen nach DIN 57817/VDE 0817 [VDE-Richtlinie

  7. Verwendung von Kabeln und isolierten Leitungen für Fernmeldeanlagen und Informationsverarbeitungsanlagen; Besondere Richtlinie für selbsttragende Fernmelde-Luftkabel auf Starkstrom-Freileitungen über 1 kV nach DIN 57818/VDE 0818 [VDE-Richtlinie

    CERN Document Server

    Deutsches Institut für Normung. Berlin

    1983-01-01

    Verwendung von Kabeln und isolierten Leitungen für Fernmeldeanlagen und Informationsverarbeitungsanlagen; Besondere Richtlinie für selbsttragende Fernmelde-Luftkabel auf Starkstrom-Freileitungen über 1 kV nach DIN 57818/VDE 0818 [VDE-Richtlinie

  8. Dynamic MR imaging: Follow-up study after femoral head core decompression and rhBMP-2 instillation in patients with avascular necrosis of the femoral head; Dynamische Magnetresonanztomographie (MRT): Verlaufsbeobachtung nach Femurkerndekompression und Auffuellung mit rekombinantem, humanem Bone morphogenetic Protein-2 (rhBMP-2) bei avaskulaerer Femurkopfnekrose

    Energy Technology Data Exchange (ETDEWEB)

    Schedel, H. [Klinik Prof. Schedel, Kellberg (Germany); Schneller, A. [Humboldt-Universitaet, Berlin (Germany). Klinik fuer Allgemein- und Transplantationschirurgie; Vogl, T.; Mueller, H.F.; Maeurer, J.; Felix, R. [Humboldt-Universitaet, Berlin (Germany). Strahlenklinik und Poliklinik; Suedkamp, N. [Humboldt-Universitaet, Berlin (Germany). Unfall- und Wiederherstellungschirurgie; Eisenschenk, A. [Freie Univ. Berlin (Germany). Orthopaedische Klinik und Poliklinik

    2000-07-01

    Material and Methods: Six patients with avascular necrosis of the femoral head ARCO-stage I- or II-lesions were treated surgically by femoral head core decompression. Three of these patients were additionally treated with rhBMP-2-instillation. The progression or regression could be confirmed by T1- and T2-weighted spinecho-sequences (zero, four, ten, sixteen weeks and 24 months follow up). Results: Corresponding ARCO-classification with partly more sensitive measurement of vitality signs in comparison to the optical X-ray classification. The objective, quantitative measurement of signalintensity post contrast medium reduces the influence of experience and level of education. The dynamic sequences results are reproducable. (orig.) [German] Material und Methoden: Sechs Patienten mit avaskulaerer Nekrose des Femurkopfes des Stadiums I oder II nach ARCO wurden einer Femurkerndekompression unterzogen. Drei dieser Patienten erhielten zusaetzlich eine rhBMP-2-Auffuellung. Zum Zeitpunkt null, vier, zehn, sechszehn Wochen und 24 Monaten post OP erfolgte die kernspintomographische Untersuchung mit T1- und T2-gewichteten Sequenzen unter besonderer Beruecksichtigung der dynamischen Untersuchungssequenz nach Gabe von Gd-DTPA (Gadopentetsaeure, Dimegluminsalz; Magnevist {sup trademark}) zur Dokumentation der Signalintensitaetssteigerung pro Zeiteinheit in der Nekroseregion. Ergebnisse: Uebereinstimmende Stadienklassifikation nach ARCO mit zum Teil empfindlicherer Messung von Vitalitaetszeichen im Vergleich zu rein visuellen roentgenologischen Einteilung. Die objektive, quantitative Messung des Signalintensitaetssteigerungsverhaltens nach Kontrastmittelgabe im Bereich der Femurkopfnekrose kann den Einfluss von subjektiven Eigenschaften des Untersuchers (Erfahrung, Ausbildungsstand) reduzieren, wobei die Ergebnisse der Dynamiksequenzen objektiv reproduzierbar sind. (orig.)

  9. Prevention of heterotopic ossification after total hip replacement. Using nonsteroidal antiinflammatory drugs versus radiation therapy: a prospective randomized trial; Prospektive Studie zur Vermeidung heterotoper Ossifikationen nach Hueftgelenksersatz. Nichtsteroidales Antirheumatikum versus Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Koelbl, O.; Flentje, M. [Wuerzburg Univ. (Germany). Klinik und Poliklinik fuer Strahlentherapie; Eulert, J.; Barthel, T.; Knelles, D.; Kraus, U. [Orthopaedische Klinik Koenig-Ludwig-Haus Wuerzburg (Germany)

    1997-12-01

    Purpose: Two prospective trials were undertaken to assess the comparative efficacy of early postoperative irradiation with different radiation doses versus the postoperative use of nonsteroidal antiinflammatory drugs (NSAID) for prevention of heterotopic ossification (HO) following prothetic total hip replacement (THP). Patients and Method: Between 1992 and 1994 585 patients received THP. These patients were randomized in two longitudinal studies each with 3 treatment arms comparing postoperative irradiation with 4x3 Gy (101 patients), 1x5 Gy (93 patients), 1x7 Gy (95 patients) and the postoperative use of the NSAID indometacin for 7 days (113 patients) respectively for 14 days (90 patients) and acetyl salicyl acid (ASS) for 14 days (93 patients). Heterotopic ossification was scored according to the Brooker grading system. One hundred patients receiving no prophylactic therapy after total hip arthroplasty between 1988 and 1992 were analysed and defined as historical control group. Conclusion: Prophylactic irradiation of the operative site after hip replacement is more effective than the use of NSAID. Because no significant difference between the fractionated single dose irradiation was found and the latter is more comfortable for patients and more economical, irradiation with single 7 Gy fraction should be prefered. (orig./MG) [Deutsch] Zielsetzung: Mittels zweier prospektiver Studien wurde untersucht, inwieweit eine postoperative Radiotherapie mit unterschiedlichen Bestrahlungsdosen und die postoperative Gabe nichtsteroidaler Antirheumatika die Inzidenz heterotoper Ossifikationen nach endoprothetischem Gelenkersatz der Huefte reduzieren koennen. Patienten und Methode: 585 Patienten erhielten in den Jahren 1992 bis 1994 eine Totalendoprothese des Hueftgelenks. Diese Patienten wurden innerhalb zweier longitudinal angelegter, jeweils dreiarmiger Studien randomisiert. Verglichen wurde dabei eine postoperative fraktionierte Bestrahlung mit 4x3 Gy (101 Patienten), eine

  10. AOX determination in industrial waste water according to EN 1485, DEV H14. Experience with high salt freights and interfering organic matter; AOX-Bestimmungen in Industrieabwaessern nach EN 1485, DEV H14 Erfahrungen mit hohen Salzfrachten und organischen Stoerstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Helmreich, B. [Technische Univ. Muenchen, Garching (Germany). Lehrstuhl und Pruefamt fuer Wasserguete- und Abfallwirtschaft

    1999-07-01

    AOX determination in industrial waste water is not always trivial on account of high salt freights or high organic loads. Interfering substances of inorganic or organic nature can cause increases or decreases of readings that often are not plausible or reproducible. In most cases the AOX enrichment step is limiting to quantitative analysis. In the present work, enrichment in two industrial waste waters was critically assessed according to EN 1485 DEV H14. In addition, experience with the enrichment method according to Dr. Lange is reported. For the elimination of high salt freights beside a low organic concentration, cleanup by means of solid-phase extraction is considered. The results suggest that the standardized procedure is not universally applicable to any type of sample. However, appropriate action can minimize flaws of enrichment and, thereby, AOX determination. (orig.) [German] Die AOX-Bestimmung aus Industrieabwaessern ist aufgrund hoher Salzfrachten oder hoher organischer Belastungen nicht immer trivial. Stoerstoffe anorganischer wie auch organischer Art koennen zu Mehr- oder Minderbefunden fuehren, die oft nicht plausibel und reproduzierbar sind. In den meisten Faellen ist der Anreicherungsschritt des AOX fuer die quantitative Analyse limitierend. In der vorliegenden Arbeit wurde die Anreicherung nach den EN 1485 DEV H14 fuer zwei Industrieabwaesser kritisch betrachtet. Zudem werden Erfahrungen mit der Anreicherungsmethode nach Dr. Lange vorgestellt. Zur Entfernung hoher Salzfrachten neben einer geringen organischen Konzentration wurde ein Clean-up mittels Festphasenextraktion betrachtet. Die Ergebnisse legen nahe, dass das genormte Verfahren nicht universell auf jeden Probentyp anwendbar ist. Durch ein gezieltes Vorgehen koennen jedoch Fehler bei der Anreicherung und damit bei der AOX-Bestimmung minimiert werden. (orig.)

  11. Analysis of binding delivery agreements in electricity supply contracts from the angle of German and EC antitrust law; Die Beurteilung von Bezugsbindungen in Elektrizitaetsliefervertraegen nach deutschem und EG-Kartellrecht

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, U.

    1998-12-31

    Binding delivery agreements in the form of contractual clauses determining exclusive total or partial coverage of electricity demand, take-or-pay contracts, or minimum purchase quota, are standard provisions of energy supply contracts concluded in order to ensure amortization of earlier commitments such as investment or other obligations. In the wake of the recent amendment of the German energy industry law for implementation of the deregulation of electricity markets in EU Member States, those agreements have become items of concern in the eyes of the cartel authority. In Germany, where utilities as from 1990 had to invest particularly strongly into the modernisation of existing power plants and distribution systems in the eastern parts of the country, review of the legality of those agreements touches upon vital interests of the electric power industry. The article here examines the situation with reference to EU legislation and the German law against restraints on competition (GWB). (orig./CB) [Deutsch] Bezugsbindungen in Gestalt von Gesamt- oder Teilbedarfsdeckungsklauseln, Take-or-Pay-Verpflichtungen oder Mindestbezugspflichten sind regelmaessig Bestandteile von Elektrizitaetsliefervertraegen, die zum einen der Amortisation bereits getaetigter Investitionen sowie eingegangener Verpflichtungen dienen. Insbesondere nach der Reform des deutschen Energiewirtschaftsrechts gewinnt die Frage der kartellrechtlichen Zulaessigkeit von Bezugsbindungen besondere Relevanz. Nicht zuletzt vor dem Hintergrund der besonders kapitalintensiven Investitionen zur Modernisierung der ostdeutschen Elektrizitaetsversorgung stellt sich daher die Frage, ob und inwieweit Bezugsbindungen nach der Aenderung des rechtlichen Ordnungsrahmens in der leitungsgebundenen Energieversorgung zulaessig sind. Der rechtliche Rahmen fuer die Beurteilung der Zulaessigkeit von Bezugsbindungen wird insbesondere durch die EU-Wettbewerbsregeln sowie die Bestimmungen des GWB gebildet. (orig.)

  12. Quality rating of MR-cholangiopancreatography with oral application of iron oxide particles; Wertigkeit der MR-Cholangiopankreatikographie nach Gabe eines oralen eisenhaltigen Kontrastmittels

    Energy Technology Data Exchange (ETDEWEB)

    Lorenzen, M.; Wedegaertner, U.; Fiehler, J.; Adam, G. [Universitaetsklinikum Hamburg, Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie (Germany)

    2003-07-01

    nicht signifikant. Die Interobservervariabilitaet lag zwischen 0,37 fuer PGKO und 0,66 fuer re. DH. Schlussfolgerung: Die Abbildungsqualitaet saemtlicher Abschnitte des pankreatikobiliaeren Gangsystems unterscheidet sich nach oraler Gabe einer Loesferron {sup trademark} -Loesung nicht signifikant von der Untersuchung ohne Kontrastmittel. Eine generelle orale Loeseferron {sup trademark} -Gabe vor der MRCP sehen wir daher nicht als zwingend indiziert. (orig.)

  13. Science Signaling, Perspective – Cancer: Wnt/β-Catenin and MAPK Signaling: Allies and Enemies in Different Battlefields, April 2012 [Science Signaling, Ausblick – Krebs: Wnt/β-Catenin- und MAPK-Signaltransduktion: Verbündete und Feinde in unterschiedlichen Kampfzonen, April 2012

    Directory of Open Access Journals (Sweden)

    Forsythe, Katherine H.

    2012-07-01

    Full Text Available [english] Research published in represents major advances in cell signaling in many disciplines, including the rapidly expanding areas of signaling networks, systems biology, synthetic biology, computation and modeling of regulatory pathways, and drug discovery. The published research content offers discoveries that substantially refine current understanding of important signaling processes, provide new concepts, and are likely to find application in multiple biological systems. Two papers this year in describe previously unknown links between two signaling pathways that are associated with cancer – melanoma and colon cancer. The Perspective, and MAPK Signaling: Allies and Enemies in Different Battlefields,” describes how both studies have implications for the development of combination therapies for skin and colon cancer .[german] Die in veröffentlichten Forschungsarbeiten stellen die wichtigsten Fortschritte zur Zellsignaltransduktion in vielen Fachbereichen dar und umfassen die schnell wachsenden Gebiete der Signaltransduktionsnetzwerke, der Systembiologie, der synthetischen Biologie, der Berechnung und Modelldarstellung regulatorischer Pfade sowie der Pharmaforschung. Die veröffentlichten Forschungsergebnisse bieten Entdeckungen, die das derzeitige Wissen zu wichtigen Signaltransduktionsprozessen beträchtlich vertiefen, neue Konzepte anbieten und wahrscheinlich Anwendung in mehreren biologischen Systemen finden werden. Zwei Arbeiten, die dieses Jahr in erschienen sind, beschreiben zuvor noch nicht bekannte Zusammenhänge zwischen zwei Signaltransduktionswegen, die mit Krebs (Melanom und Darmkrebs assoziiert sind. Der Ausblick „Wnt/β-Catenin- und MAPK-Signaltransduktion: Verbündete und Feinde in unterschiedlichen Kampfzonen“ beschreibt, wie beide Studien Auswirkungen auf die Entwicklung von Kombinationstherapien gegen Haut- und Darmkrebs haben .

  14. Diagnosis and differential diagnosis of hydrocephalus in adults; Diagnostik und Differenzialdiagnostik des Hydrozephalus beim Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Langner, Soenke; Mensel, Birger; Kuehn, Jens Peter; Kirsch, Michael [Univ. Medicine Greifswald (Germany). Inst. for Diagnostic Radiology and Neuroradiology; Fleck, Steffen; Baldauf, Joerg [Univ. Medicine Greifswald (Germany). Dept. of Neurosurgery

    2017-08-15

    Hydrocephalus is caused by an imbalance of production and absorption of cerebrospinal fluid (CSF) or obstruction of its pathways, resulting in ventricular dilatation and increased intracranial pressure. Imaging plays a crucial role in the diagnosis, differential diagnosis and planning of treatment. This review article presents the different types of hydrocephalus und their typical imaging appearance, describes imaging techniques, and discusses differential diagnoses of the different forms of hydrocephalus. Imaging plays a central role in the diagnosis of hydrocephalus. While magnetic resonance (MR) imaging is the first-line imaging modality, computed tomography (CT) is often the first-line imaging test in emergency patients.

  15. Die Rechtsstellung von Ausländern nach staatlichem Recht und Völkerrecht. Herausgegeben von Jochen Abr. Frowein und Torsten Stein. (Beiträge zum ausländischen öffentlichen Recht und Völkerrecht, Band 94) / Henn-Jüri Uibopuu

    Index Scriptorium Estoniae

    Uibopuu, Henn-Jüri, 1929-2012

    1988-01-01

    Raamatuarvustus: Die Rechtsstellung von Ausländern nach staatlichem Recht und Völkerrecht = The legal position of aliens in national and international law = Le régime juridique des étrangers en droit national et international / Max-Planck-Institut für ausländisches öffentliches Recht und Völkerrecht ; herausgegeben von Jochen A. Frowein, Torsten Stein. Berlin [etc.] : Springer, 1987

  16. Device diagnosis in support of asset management. PROFIBUS responds to user demands for more simplified diagnosis; Mit Geraetediagnose zum Asset Management. PROFIBUS reagiert auf den Anwenderwunsch nach Straffung der Feldgeraetediagnose

    Energy Technology Data Exchange (ETDEWEB)

    Diedrich, C. [Institut fuer Automation und Kommunikation e.V., Barleben (Germany); Jecht, U. [UJ Prozessanalytik, Baden-Baden (Germany); Oestreich, V. [PROFIBUS Nutzerorganisation e.V., Karlsruhe (Germany); Rachut, H. [Siemens AG, Karlsruhe (Germany); Tepper, C.J. [Endress und Hauser Process Solutions AG, Reinach (Switzerland)

    2004-04-01

    Diagnosis information of intelligent field devices represents an important economic potential of fieldbus systems in the process industry. This issue is of high actuality and diversity: Manufacturers of field devices intend to implement more and more diagnosis functionalities, fieldbus organisations are trying to harmonize them, and users, based on experiences from many plants, request increasingly more simple and more unified information. PROFIBUS International has quickly responded on these concerns and presents a proposal for PROFIBUS PA, the PROFIBUS solution for Process Automation, how to reduce and focus the high amount of diagnosis information from field devices to an applicable extent. (orig.) [German] In verfahrenstechnischen Anlagen mit Feldbusinstallationen stellen die aus den Feldgeraeten erhaeltichen Informationen ein bedeutendes Nutzenpotenzial dar. Das Thema ist von hoher Dynamik und Vielfalt gepraegt. Die Hersteller ruesten ihre intelligenten Geraete mit immer mehr Funktionen zur Bereitstellung von Informationen fuer Diagnosezwecke aus, die Feldbusorganisationen bemuehen sich um deren herstelleruebergreifende Festlegung, und die Anwender formulieren auf Basis von Praxiserfahrungen ihre Wuensche nach mehr Einfachheit und Einheitlichkeit der 'Informationsflut'. Die PROFIBUS Nutzerorganisation e.V. hat dieser Situation Rechnung getragen und legt fuer die Diagnose bei Feldgeraeten der Prozesstechnik (PROFIBUS PA) einen Vorschlag zur Straffung und Anpassung an die Anwenderwuensche vor. (orig.)

  17. Urban Image Construction in Macau in the First Decade after the “Handover”, 1999-2008 Zur Konstruktion des Stadtbildes von Macau im ersten Jahrzehnt nach der "Übergabe" (1999-2008

    Directory of Open Access Journals (Sweden)

    Hendrik Tieben

    2009-04-01

    Full Text Available This paper describes the transformation of Macau’s urban image in the first decade after the “handover” of the Portuguese enclave to the People’s Republic of China (PRC. In the pre-handover years and the first years of the newly established Macau Special Administrative Region (MSAR, urban interventions created an image thought to assure the continuity of Macau’s Eurasian identity along with future financial stability. In 2002, with the governmental decision not to renew the local gambling monopoly, Macau’s urban image was radically transformed. The liberalization of the gambling industry after Macau’s return to the PRC was combined with the deregulation of building heights, developer-friendly land sales, a growing number of migrant workers, and the liberalization of travel restrictions for mainland visitors. These deregulations were based on decisions by the MSAR and the PRC governments, respectively, and led to the exponential growth of Macau’s GDP within only six years. This paper describes how, through these decisions, Macau’s urban image and space have been transformed. Der Beitrag beschreibt die Transformation des Stadtbildes von Macau nach der "Übergabe" der portugiesischen Enklave an die Volksrepublik China.

  18. Lattice dynamics of silver and gold on Krebs's model

    International Nuclear Information System (INIS)

    Bertolo, L.A.; Shukla, M.M.

    1975-01-01

    Phonon dispersion relations along the principal symmetry directions of gold and silver have been calculated for phonons propagating at room temperature. The calculated curves are compared with the recent experimental findings. Also calculated are the lattice heat capacities of these metals at absolute zero temperature. Computed(theta - T) curves of them show good agreements with experimental results. The effect of various forms of the dielectric screening functions on the calculated phonon spectrum of gold and silver has also been investigated

  19. A Novel Large-scale Mentoring Program for Medical Students based on a Quantitative and Qualitative Needs Analysis [Aufbau eines innovativen Mentorenprogramms für eine große Zahl Medizinstudierender nach quantitativer und qualitativer Bedarfsanalyse

    Directory of Open Access Journals (Sweden)

    von der Borch, Philip

    2011-05-01

    Ludwig-Maximilians-Universität München (LMU und beschreiben die Einführung eines innovativen, umfassenden Mentorenprogramms.Methoden: Die Bedarfsanalyse wurde durch eine an alle Medizinstudierenden der Medizinischen Fakultät gerichtete Online-Umfrage durchgeführt (n=578 von 4.109 Studenten, Rücklauf 14,1%. Außerdem führten wir Fokusgruppen mit Medizinstudenten (n=24 und ärztlichem Personal (n=22 durch. Schließlich wurden alle Studierenden, die sich für das individuelle Mentorenprogramm interessierten, zu ihren Erwartungen befragt (n=534.Ergebnisse: 83% der Medizinstudierenden äußerten Zufriedenheit mit dem aktuellen Münchener Curriculum. Im Gegensatz dazu fühlten sich nur 36.5% der Studierenden unserer großen Fakultät ausreichend im Studium betreut, und 86% der Studierenden äußerten den Wunsch nach mehr Betreuung. Die Rolle ihres Mentors wünschten sich 55.6% "sehr" als Berater, Kontaktvermittler (36.4% und Ideenlieferant (28.1%. Die Themen, die angehende Mentees im Vorfeld "sehr" mit ihren Mentoren besprechen wollten, waren die Doktorarbeit (56.6%, das Praktische Jahr (55.8% und Auslandsaufenthalte (45.5%.Schlussfolgerungen: Wir haben anhand der Erkenntnisse unserer Bedarfsanalyse ein innovatives, zweigleisiges Konzept entworfen, das aus einem beliebig skalierbaren individuellen Mentorenprogramm für Studierende in klinischen Semestern und einem Peer Mentoring-Programm für sämtliche Medizinstudierende unserer Fakultät besteht. Ein Jahr nach der Initiierung des Programms haben über 300 Studierende im klinischen Studienabschnitt einen individuellen Mentor aus der Fakultät ausgewählt und 1.503 Studierende und Ärzte nahmen am Peer Mentoring teil.

  20. Aspects of vulnerable patients and informed consent in clinical trials [Aspekte schutzbedürftiger Patienten sowie der Einwilligung nach Aufklärung in klinischen Prüfungen

    Directory of Open Access Journals (Sweden)

    Hundt, Ferdinand

    2013-01-01

    Full Text Available [english] Scope: To discuss the rationale behind informed consent in clinical trials focusing on vulnerable patients from a European and German viewpoint. Methods: Scientific literature search via PubMed, Medline, Google.Results: Voluntary informed consent is the cornerstone of policies regulating clinical trials. To enroll a patient into a clinical trial without having obtained written and signed consent is to be considered as a serious issue in the conduct of a clinical trial. Development of ethical guidance for physicians started before Christ Era with the Hippocratic Oath. Main function of consent, as articulated in all guidelines developed for clinical research, is to facilitate an individual’s freedom of choice, respect autonomy, and thus to ensure welfare of the participants in clinical trials. Minors are unable to provide legally binding informed consent, this issue is addressed through a combination of parental permission and minor’s assent. Illiteracy is a critical problem that affects all corners of our earth; it has no boundaries and exists among every race and ethnicity, age group, and economic class. New strategies to improve communication with patients including the use of videotapes or animated cartoon illustrations could be taught. Finally the time with the potential participant seems to be the best way to improve understanding. Conclusion: Discovery of life saving and life enhancing new treatments requires partnership that is based on good communication and trust between patients and researchers, sponsors, ethics committees, authorities, lawyers and politicians so that vulnerable patients can benefit from the results of well controlled clinical trials. [german] Ziel: Diskussion der Aspekte der Einwilligung schutzbedürftiger Patienten nach Aufklärung zur Teilnahme an klinischen Prüfungen aus europäischem und deutschem Blick.Methoden: Wissenschaftliche Literaturrecherche via PubMed, Medline und Google. Ergebnis: Das

  1. Long term results of surgery in Perthes disease: Comparison of X-ray and MR-studies; Spaetergebnisse nach operativer Behandlung des Morbus Perthes: Vergleich der roentgenologischen und kernspintomographischen Untersuchung

    Energy Technology Data Exchange (ETDEWEB)

    Tosch, U. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Berlin (Germany); Sparmann, M. [Orthopaedische Klinik im Oskar-Helene-Heim, Berlin (Germany); Stelling, E. [Orthopaedische Klinik im Oskar-Helene-Heim, Berlin (Germany); Tomala, D. [Strahlenklinik und Poliklinik, Universitaetsklinikum Rudolf Virchow, Berlin (Germany)

    1995-05-01

    Twenty patients treated by surgery for Perthes` disease were studied between 4 and 9 years postoperatively. In the clinical investigation eight patients complained of persistent stress-induced pain. In nine patients flexion, extension, ab- and adduction of the hip joint was limited. In the MRI-Study of ten hip joints a reduction of fatty marrow was seen in the femoral head. In 11 hip joints of patients complaining of persistent pain, a deformation of the femoral head (n = 2), a dysplasia of the femoral metaphysis (n = 2), and diaphysis (n = 4) or both (n = 2) were seen. In another five patients an additional dysplasia of the acetabulum was visualized. All these findings were diagnosed by X-ray studies as well. However, only by MRI were the extents of the postoperative defects of femoral spongiosa diagnosed in fifteen hip joints. (orig.) [Deutsch] 20 wegen eines Morbus Perthes operierte Patienten wurden 4-9 Jahre nach einer Umstellungsosteotomie klinisch, radiologisch und kernspintomographisch untersucht. Bei der klinischen Nachuntersuchung gaben 8 Patienten persistierende Beschwerden bei Belastung an. Bei der koerperlichen Untersuchung war die Flexion und Extension bei 9 sowie die Abduktion und Adduktion bei einem Patienten eingeschraenkt. Bei der kernspintomographischen Untersuchung liessen sich bei 10 Hueftgelenken Residuen des M. Perthes im Fettmark des Femurkopfs nachweisen. An 11 Hueftkoepfen wurden pathologische Veraenderungen wie eine Femurkopfentrundung (n = 2), eine Deformierung der Femurmeta- (n = 3) und -diaphyse (n = 4) bis hin zur hirtenstabfoermigen Konfiguration (n = 2) nachgewiesen. Bei 5 Patienten wurde eine Pfannendysplasie gefunden. Diese Befunde waren auch roentgenologisch darzustellen. Als postoperative Defekte waren im Schaftmark des Femurs eine langstreckige Hoehlenbildung mit Zysten oder durch Fettmark aufgefuellte Spongiosadefekte bei 15 Hueftgelenken nur kernspintomographisch nachweisbar. (orig.)

  2. Clinical course of a partially thrombosed, symptomatic aneurysm of the basilar artery tip with partial recanalization subsequent to coiling; Verlaufsbeschreibung eines teilthrombosierten symptomatischen Basilariskopfaneurysmas mit teilweiser Rekanalisierung nach Coiling

    Energy Technology Data Exchange (ETDEWEB)

    Moeller, V. [Universitaet des Saarlandes, Abteilung fuer Neuroradiologie, Homburg (Germany); Klinikum Saarbruecken, Institut fuer bildgebende Diagnostik und Interventionen, Saarbruecken (Germany); Axmann, C.; Reith, W. [Universitaet des Saarlandes, Abteilung fuer Neuroradiologie, Homburg (Germany)

    2006-05-15

    A 72-year-old patient was referred to the neuroradiological department for diagnostic angiography. She was suffering from vertigo and double vision. Magnetic resonance imaging performed elsewhere had demonstrated a giant aneurysm of the basilar artery tip 2 cm in diameter. Angiography revealed a large aneurysm with a broad neck that was partially thrombosed, which precluded closure by coiling. Neurosurgical management by clipping also appeared to be unsuitable because of the proximity to the cerebrum. The decision was reached to proceed expectantly by closely monitoring the clinical course. When the aneurysm increased in size in the ensuing weeks, coiling was performed successfully. Angiographic follow-up showed reperfusion of the aneurysm neck and closure was again achieved by repeat coiling. Reperfusion is not a rare complication following coiling and often necessitates renewed intervention. (orig.) [German] Eine 72-jaehrige Patientin wurde in der neuroradiologischen Abteilung zur diagnostischen Angiographie vorgestellt. Sie litt unter Schwindel und Doppelbildern. Eine auswaertige MR-Untersuchung des Gehirns zeigte ein Riesenaneurysma des Basilariskopfes mit einem Durchmesser von 2 cm. Die Angiographie zeigte ein grosses Aneurysma mit breitem Hals, das teilweise thrombosiert war. Dies liess einen Verschluss durch Coiling nicht zu. Eine neurochirurgische Behandlung durch Klippung erschien wegen der Naehe zum Mittelhirn ebenfalls ungeeignet. Man einigte sich auf ein abwartendes Vorgehen durch eine engmaschige Verlaufsbeobachtung. Als das Aneurysma in den folgenden Wochen eine Groessenzunahme zeigte, wurde erfolgreich ein Coiling durchgefuehrt. Eine angiographische Verlaufskontrolle zeigte eine Reperfusion des Aneurysmahalses. Erneut konnte ein Verschluss durch Coiling erzielt werden. Eine Reperfusion ist keine seltene Komplikation nach Coiling, die oft eine erneute Intervention erfordert. (orig.)

  3. Early clinical phase of patient's management after polytrauma using 1- and 4-slice helical CT; Fruehes klinisches Management nach Polytrauma mit 1- und 4-Schicht-Spiral-CT

    Energy Technology Data Exchange (ETDEWEB)

    Kloeppel, R.; Kahn, T. [Klinik und Poliklinik fuer Diagnostische Radiologie, Universitaetsklinikum Leipzig (Germany); Schreiter, D. [Chirurgische Intensivtherapieabteilung, Zentrum fuer Chirurgie, Universitaetsklinikum Leipzig (Germany); Dietrich, J. [Abt. Neuroradiologie der Klinik und Poliklinik fuer Diagnostische Radiologie, Universitaetsklinikum Leipzig (Germany); Josten, C. [Klinik und Poliklinik fuer Unfall- und Wiederherstellungschirurgie, Zentrum fuer Chirurgie, Universitaetsklinikum Leipzig (Germany)

    2002-07-01

    In the early clinical phase the comprehensive imaging of patients with multiple trauma using helical CT is already established. Aim of this study was to assess whether MSCT may improve the patient management and the diagnostic results.The procedure is designed as follows: after life-thretening treatment x-ray of chest and ultrasound are carried out in the emergency room. Then the patient is moved to CT. From 1998 to december 2000 241 patients were examined using a single slice helical CT (Somatom plus 4), in 2001 79 patients using a 4-slice helical CT (Somatom VZ, Siemens Med.Sol.). After CT selected radiograms of the extremities were taken.359 of 360 procedures were carried out successfully. Excluding 1 case (death during 1-sl. h CT) all relevant lesions of head, neck, and body were diagnosed. Although the patients had an injury severity score of {approx}30. The change from 1slice-helical CT to 4 slice-helical CT allowed us to reduce the stay in the CT room from 28 to 16 min. The total lethality decreased by {approx}4%.Advantages for the patient arose from the standardized examination protocol using multislice CT. If integrated in an interdisciplinary management concept, it is a good compromise between examination time, comprehensive diagnostic imaging, life-saving therapeutic procedures, and therapy planning. (orig.) [German] Die klinische Erstversorgung Polytraumatisierter schliesst inzwischen in vielen Unfallkliniken den fruehzeitigen Einsatz der Spiral-CT ein. Kann die neuerlich eingefuehrte Mehrschicht-Spiral-CT Ergebnisse und Patientenmanagement weiter verbessern?Nach lebensrettenden Sofortmassnahmen, Thoraxroentgen und Notsonographie im Schockraum erfolgte die CT: Von 1998-2000 wurden 241 Patienten mit einem 1-Schicht-Spiral-CT (Somatom plus 4) und in 2001 79 Patienten mit einem 4-Schicht-Spiral-CT (Somatom VZ, beide Siemens Med. Sol.) untersucht. Klinisch ausgewaehlte Extremitaetenaufnahmen wurden ergaenzt.359 von 360 Untersuchungen verliefen erfolgreich

  4. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 2; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 2: Berechnungsmethoden, aktuelle Modelle und Modellgleichungen

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W; Rogazewski, P; Schindler, M [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A; Albrecht, M; Lambert, M; Steinbach, J [Technische Univ. Berlin (Germany)

    2000-07-01

    Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  5. Determination and calculation of hazardous incident scenarios in accordance with the 3rd hazardous incident administrative instruction. Vol. 1; Ermittlung und Berechnung von Stoerfallablaufszenarien nach Massgabe der 3. Stoerfallverwaltungsvorschrift. Bd. 1: Methodischer Teil zum Erarbeiten von Stoerfallablaufszenarien

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, W.; Rogazewski, P.; Schindler, M. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg; Acikalin, A.; Albrecht, M.; Lambert, M.; Steinbach, J. [Technische Univ. Berlin (Germany)

    2000-07-01

    Stoerfaellen sowie zu Bedingungen des Standortes und der Anlage die erforderlichen Grundannahmen zum Stoerfallablauf gewinnen kann. Unterschieden nach Stofffreisetzungen, Explosionen und Braenden wird jeweils auf die konkreteren Hinweise im Anhang 1 zur Abschaetzung von Quelltermen, im Anhang 2 zur Abschaetzung der Ausbreitung und im Anhang 3 zur Abschaetzung der Auswirkungen verwiesen. Der Anhang 4 enthaelt einige Erlaeuterungen zu den Anhaengen 1 bis 3. Mit einer Sammlung von 15 Beispielen fuer Stoerfallablaufszenarien wird im Anhang 5 das im Leitfaden beschriebene methodische Vorgehen veranschaulicht und erlaeutert. Im Anhang 6 werden die auf dem deutschen Markt erhaeltlichen DV-Programme (Software) zur Berechnung von Stoerfallablaufszenarien beschrieben und kommentiert. Der Band 2 untermauert das Vorgehen im Hinblick auf Berechnungsmethoden, aktuelle Modelle und Modellgleichungen aus wissenschaftlicher Sicht. (orig.)

  6. Bundes-Immissionsschutzgesetz (Federal Nuisance Protection Act). BImSchG, BImSch-Verordnungen, EMASPrivilegV, Biokraft-NachV, TA Luft, TA Laerm, USchadG, TEHG, ZuG 2012, ZuV 2012, EHVV 2012, FlugISchG, 2. FlugLSV. 29. ed.; Bundes-Immissionsschutzgesetz. BImSchG, BImSch-Verordnungen, EMASPrivilegV, Biokraft-NachV, TA Luft, TA Laerm, USchadG, TEHG, ZuG 2012, ZuV 2012, EHVV 2012, FlugISchG, 2. FlugLSV

    Energy Technology Data Exchange (ETDEWEB)

    Hansmann, Klaus (ed.)

    2011-07-01

    After a detailed introduction, the book goes into detail about the specifications of the Federal Immission Control Act (BImSchG). Also discussed are all regulations for the implementation of the BImSchG, the EMAS-Privilegierungsverordnung (privileges ordinance), the biofuels sustainibility ordinance (Biokraft-NachV), the Technical Instructions on Air Quality Control (TA Luft) and the Technical Instructions on Noise Control (TA Laerm), the Environmental Damage Act (Umweltschadensgesetz), the Greenhouse Gas Emissions Act (Treibhausgas-Emissionshandelsgesetz), the Allocation Act (Zuteilungsgesetz 2012), the Allocation Ordinance (Zuteilungsverordnung 2012), the Auctioning Ordinance (Emissionshandels-Versteigerungsverordnung 2012), and the Aircraft Noise Act (Gesetz zum Schutz gegen Fluglaerm) and the Ordinance on Noise Protection in Airports (Flugplatz-Schallschutzmassnahmenverordnung).

  7. Polilingvizmas kaip „grįžimas namõ“: tarp Babilono katastrofos ir Jeruzalės Sekminių stebuklo. Vlado Braziūno poezijos at(sivėrimai | Der Polylinguismus als „Rückkehr nach Hause“: zwischen der babylonischen Katastrophe und dem Pfingstwunder von Jerusalem

    Directory of Open Access Journals (Sweden)

    Skirmantas Valentas

    2006-01-01

    Full Text Available In diesem Beitrag wird ein Versuch unternommen, die Widerspiegelung von zwei philologisch wichtigen Episoden der Heiligen Schrift in der modernen Poesie zu vermitteln. Es geht um die Erzählung von der babylonischen Sprachenverwirrung im Buch der Anfänge und um das in den Apostelgeschichten erwähnte Pfingstwunder, die beide unter einen Begriff Polylinguismus fallen.Der Polylinguismus in der Poesie ist als eine syntagmatische Mehrsprachigkeit, anders gesagt, als eine implizite Benennung desgleichen Denotats in einigen Sprachen, zu betrachten.Der verallgemeinernde Begriff „Rückkehr nach Hause“ lässt zwei Begriffe in Verbindung setzen: die sich nach der babylonischen Katastrophe etablierte Mehrsprachigkeit und das Pfingstwunder als eine Möglichkeit die verwirrten Sprachen wieder zu einem Harmonischen zusammenzufügen.Da die Poesie als ein Grammatik modellierender Text vorliegt, ist eine Idee hervorzuheben, dass neben einer üblichen Sprache in der Poesie eine andere Sprache mit völlig anderen Regeln aufgedeckt werden muss.Als eines der Grundmerkmale der üblichen Sprache ist ein in ihr enthaltenes Oppositionsystem zu betrachten. Als Grundmerkmal einer anderen Sprache gilt dagegen das Schwinden der grundlegenden Oppositionen, das einen endlosen und periodischen Text schafft.Der Polylinguismus der Poesie wird in den linguistischen Geschichten am deutlichsten sichtbar. Der Polylinguismus in der Poesie, der dem Simultandolmetschen nahsteht, führt uns auf das Pfingstwunder zurück.

  8. Signifikante Verbesserungen eines klinischen Untersuchungskurses nach einfachen strukturierten Veränderungen des Lehrinhalts und der Lehrmethoden [Significant improvement of a clinical training course in physical examination after basic structural changes in the teaching content and methods

    Directory of Open Access Journals (Sweden)

    Bott-Flügel, Lorenz

    2013-05-01

    von ihnen erlernten Untersuchungstechniken führen.Methoden: In drei medizinischen Kliniken der Technischen Universität München wurden im Sommersemester 2010 die quantitativen Evaluationsergebnisse (deutsches Schulnotensystem, Noten 1-6 von insgesamt 49 Studierenden von einem Kurstag vor und einem Kurstag nach strukturierten Verbesserungsmaßnahmen des klinischen Untersuchungskurses verglichen. Zum Einsatz kamen strukturierte Instruktion der Dozenten, Handouts und über das Internet verfügbares Zusatzmaterial.Ergebnisse: Es wurden 47 Evaluationsbögen vor und 34 Evaluationsbögen nach den Verbesserungsmaßnahmen ausgefüllt. Die oben genannten Maßnahmen führten zu signifikanten Verbesserungen der Evaluationsnoten in folgenden Bereichen: Einführen ins jeweilige Kursthema (von 2,4±1,2 auf 1,7±1,0, p=0,002 und in hygienische Maßnahmen (von 3,8±1,9 auf 2,5±1,8, p=0,004, strukturiertes Vorführen der einzelnen Untersuchungsschritte (von 2,9±1,5 auf 1,8±1, p=0,001, Üben der Untersuchungsschritte (von 3,1±1,8 auf 2,2±1,4, p=0,030, strukturiertes Feedback zur Untersuchungstechnik (von 3,0±1,4 auf 2,3±1,0, p0,=0,007, Verwenden von Handouts (von 5,2±1,4 auf 1,8±1,4, p<0,001, Tipps zu weiterem Lernmaterial (von 5,0±1,4 auf 3,4±2,0, p<0,001, Lernerfahrung insgesamt (von 2,4±0,9 auf 1,9±0,8, p=0,017 und Selbsteinschätzung der Studenten bezüglich der Sicherheit bei der Durchführung einer körperlichen Untersuchung (von 3,5±1,3 auf 2,5±1,1, p<0,001.Zusammenfassung: Strukturierte Verbesserungsmaßnahmen führten zu signifikanten Verbesserungen der Evaluationsnoten eines klinischen Untersuchungskurstages in den Bereichen „Vorbereitung der Dozenten“, „Struktur des Kurses“ und „selbst eingeschätzte Sicherheit beim Durchführen einer Untersuchung“.

  9. Einmaliges studentisches standardisiertes Training der chirurgischen Händedesinfektion nach EN1500: Quantifizierung des Trainingseffektes, Nutzen der Methode und Vergleich mit klinischen Referenzgruppen [A single standardized practical training for surgical scrubbing according to EN1500: Effect Quantification, value of the standardized method and comparison with clinical reference groups

    Directory of Open Access Journals (Sweden)

    Wullenk, Katharina

    2013-05-01

    Full Text Available [english] The standardized training of practical competences in skills labs is relatively new among German Medical Faculties. The broad acceptance and outstanding evaluation results do not provide objective data on the efficiency and cost-efficiency of these trainings. This study aims on the quantification of the teaching effect of the surgical scrubbing technique EN1500 and its comparison with clinical references of OR personnel.Methods: 161 4 year medical students were randomized into intervention and control group. The intervention group received a 45 minute standardized peer-teaching training of practical competences necessary in the OR including the scrubbing according to EN1500. Fluorescence dye was mixed in the disinfectant solution. After hand disinfection, standardized fotographs and semi-automated digital processing resulted in quantification of the insufficiently covered hand area. These results were compared with the control group that received the training after the test. In order to provide information on the achieved clinical competence level, the results were compared with the two clinical reference groups.Results: The intervention group remained with 4,99% (SD 2,34 insufficiently covered hand area after the training compared to the control group 7,33% (SD 3,91, p[german] Die standardisierte Schulung klinisch-praktischer Fertigkeiten in sog. Skills Labs ist erst seit wenigen Jahren an deutschen Universitäten verbreitet. Den zumeist umfangreichen und sehr guten Evaluationsergebnissen stehen kaum Untersuchungen zur Effektquantifizierung und Kosten-Nutzen-Analyse gegenüber. In der vorliegenden Studie soll eine Methode zur digitalen Quantifizierung der Güte der chirurgischen Händedesinfektion vorgestellt werden sowie das Skills-Lab-Training der standardisierten Einreibemethode nach EN1500 auf seinen Effekt hin untersucht und mit OP-Pflegepersonal und Operateuren als klinische Referenzgruppen verglichen werden.Methode: 161

  10. Berufliche Reintegration nach Hirnschädigung

    OpenAIRE

    Wendel, Claudia

    2003-01-01

    Return to work after brain injury is at high risk for failure. It is of critical interest for rehabilitation clinicians to know which key factors influence successful reintegration in working conditions. The vast majority of outcome studies focus solely on injury-related facts. Despite profound knowledge concerning the importance of individual psychological processes they are often neglected in scientific investigations. The aim of the present study was to identify the influence of those psyc...

  11. In der Suche nach eigenem Sprachstandards

    Directory of Open Access Journals (Sweden)

    Lada Badurina

    1992-01-01

    Full Text Available Im Artikl wird dreifache Lösungsmöglichkeit des burgenländrich-kroatischen Sprachkomplexes vor-gesehen: Stützung auf den deutschen schriftsprachlichen Ausdruck, Übernahme des südlichen kroatischen Standards oder Aufbau eigener Sprachnorm. Neulich veröffentlichtes Werk Gradis6anskohrvatski-hrvatsko-nim§ki rjeönik zeugt über die Anbahnung der schwierigten aber zugleich annehmbarsten Lösung: Standardisierung der eigenen Sprache.

  12. Sprachvermittlung und Spracherwerb in Afrika. Deutsch nach ...

    African Journals Online (AJOL)

    erlernende Fremdsprache richtig und auf hohem Niveau sprechen zu lernen. Lehrende sollten alles daransetzen zu verhindern, dass die Lernenden in dieser Vereinfachungsphase stehen bleiben und ihre Sprache fossilieren. Die Bewusstmachung der Ähnlichkeiten von Zulu und. Deutsch kann dazu beitragen, indem man ...

  13. Erektile Dysfunktion - Was kommt nach Viagra?

    Directory of Open Access Journals (Sweden)

    Jungwirth A

    2001-01-01

    Full Text Available Man darf nie vergessen, daß es sich bei der erektilen Dysfunktion nicht um ein "Life-Style"-Thema, sondern um eine Erkrankung handelt, welche die Lebensqualität der Patienten deutlich verschlechtert. Die Therapie der erektilen Dysfunktion hat sich in den letzten Jahren revolutioniert und wie man sieht, ist sowohl die Forschung als auch die Pharmaindustrie bemüht, für den Patienten neue, bessere, schneller wirksame und nebenwirkungsärmere Medikamente zu entwickeln. Diese neuen Entwicklungen werden für uns Andrologen/Urologen das Armamentarium für die Therapie der erektilen Dysfunktion bereichern. Welche der nun genannten Substanzen letztendlich übrigbleiben und mit welchen Substanzen wir uns in der näheren Zukunft zu befassen haben, werden die weiteren Entwicklungen zeigen.

  14. Auf der Jagd nach der Weltformel

    CERN Multimedia

    Von Rauchhaupt, U

    2004-01-01

    Forscher träumen seit jeher davon, sämtliche physicakilschen Phänomene mit einem einzigen, fundamentalen Naturgesetz erklären zu können. Schon viele Denker sind daran gescheitert, selbst Einstein. Seit einigen Jahren gilt die Stringtheorie als vielversprechender Ansatz (6 pages)

  15. Sprachvermittlung und Spracherwerb in Afrika. Deutsch nach ...

    African Journals Online (AJOL)

    Teaching foreign languages in a multilingual context, such as one finds in South African schools, poses unique questions. The theory that pedagogically underpins and articulates the value of the study of foreign languages is internationally established and thus also valid in the South African context. Nevertheless, one has ...

  16. Auf der Suche nach Gotte urknall

    CERN Document Server

    heinrich, Hansjörg

    2007-01-01

    In a mega tunnel near Geneva Lake, a second big-bang will take place soon. The world elite of physics hope to answer existential questions for humanity: How was made our Universe? From where do we come? which energy holds cosmos together? (4 pages)

  17. Present DDT and lindane indoor concentrations after extensive use of wood preservatives in attics in the past; Aktuelle DDT- und Lindan-Konzentrationen in Wohnraeumen nach intensivem Holzschutzmitteleinsatz auf Dachboeden in der Vergangenheit

    Energy Technology Data Exchange (ETDEWEB)

    Rosskamp, E.; Horn, W.; Ullrich, D.; Seifert, B. [Umweltbundesamt, Berlin (Germany). Inst. fuer Wasser-, Boden- und Lufthygiene

    1999-12-01

    ausgebauten Dachwohnungen zu bestimmen. Die untersuchten behandelten Dachboeden wiesen - z.T. auch ueber 20 Jahre nach Anwendung des Schutzmittels - DDT- und Lindan-Luftkonzentrationen bis zu 4600 ng/m{sup 3} bzw. 930 ng/m{sup 3} auf. In den ausgebauten Dachwohnungen und in den Wohnungen direkt unter den behandelten Dachboeden waren die Konzentrationen an DDT und Lindan jedoch wesentlich niedriger. Die Medianwerte lagen fuer DDT bei 20 bzw. 40 ng/m{sup 3} und fuer Lindan bei 5 bzw. 20 ng/m{sup 3}. Lediglich in einigen Wohnungen betrug die DDT- oder Lindan-Konzentration in der Luft mehr als 100 ng/m{sup 3}. In diesen Faellen war auch eine direkte Biozidanwendung in den Raeumen vorgenommen worden oder es bestand direkter Luftaustausch mit einem DDT-belasteten Dachraum. Eine Exposition der Wohnungsnutzer gegenueber DDT und Lindan kann sowohl ueber die Innenraumluft als auch - insbesondere fuer Kleinkinder mit ihrem spezifischen Spielverhalten - ueber den Hausstaub erfolgen. In Wohnraeumen wurden maximal 200 mg DDT/kg Staub nachgewiesen, der Median lag mit 20 mg/kg eine Groessenordnung niedriger. Die Lindan-Staubgehalte lagen alle unter 9 mg/kg. Die fuer Kleinkinder moegliche Exposition gegenueber DDT oder Lindan im Hausstaub liegt weiter unter den aus dem ADI-Wert der WHO abgeleiteten zulaessigen Aufnahmemengen. (orig.)

  18. Radiological risk assessment of isotope laboratories according to the requirements of the radiation protection ordinance and the protective labour legislation; Beurteilung des radiologischen Risikos von Isotopenlaboratorien nach den Vorgaben der Strahlenschutzverordnung und den Richtlinien fuer Arbeitssicherheit

    Energy Technology Data Exchange (ETDEWEB)

    Stuerm, R.P. [SafPro AG, Ausbildung und Beratung in Strahlenschutz, Basel (Switzerland); Kuster, M. [Novartis International AG, Corporate Health, Safety and Environment, Basel (Switzerland); Traub, K. [Novartis Pharma AG, Zentralstelle fuer Strahlenschutz, Basel (Switzerland)

    2001-07-01

    . 94). Isotopenlaboratorien der chemischen Industrie werden von der Schweizerischen Unfallversicherungsanstalt SUVA beaufsichtigt. Die SUVA nimmt nebst den Strahlenschutzaufgaben in den industriellen Betrieben auch die allgemeine Arbeitssicherheit wahr und hat Richtlinien zum Erstellen von Risikoanalysen erarbeitet. Bei diesen konventionellen Analysen werden die Arbeitsprozesse nach ihrem moeglichen Schadensausmass (Tod, schwere bleibende Gesundheitsschaden; leichter bleibender Gesundheitsschaden; heilbare Verletzung mit Arbeitsausfall; heilbare Verletzung ohne Arbeitsausfall) und der Eintretenswahrscheinlichkeit (haeufig; gelegentlich; selten; unwahrscheinlich; praktisch unmoeglich) in einer Risikomatrix beurteilt (grosse, mittlere und kleine Risiken). Die SUVA hat von zwei Baslern Isotopenlaboratorien des Typs B Risikobeurteilungen eingefordert, die einerseits die Gefaehrdung der Mitarbeiter und andererseits der Stadtbevoelkerung analysieren und radiologisch bewerten sollen. Fuer die Beurteilung des Mitarbeiterrisikos schlug sie vor, eine etablierte Methode aus der Arbeitssicherheit oder der Versicherungsbranche anzuwenden. Zudem muesse die Risikomatrix der von der Firmenleitung vorgegebenen Sicherheitskultur entsprechen. Damit standen wir vor dem Problem, radiologische Risiken, die sich als Strahlendosen in mSv ausdruecken lassen, fuer nicht radiologisch geschulte Manager mit den Folgen konventioneller Arbeitsunfaelle (Tod, Invaliditaet und Arbeitsausfall) bzw. mit den Reaktionen von Bevoelkerung und Politikern auf chemische Stoerfaelle zu vergleichen. Im Vortrag wird die aus Diskussionen mit der Aufsichtsbehoerde, der Firmenleitung, den Laborleitern und Labormitarbeitern entstandene Risikomatrix vorgestellt. Die Autoren sind der Meinung, dass bis anhin ein solcher Vergleich zwischen radiologischen und konventionellen Risiken noch nie etabliert worden sei und stellen ihr Resultat zur Diskussion. (orig.)

  19. Risk of leukaemia following intravenous treatment with {sup 224}Ra - results of a long term follow-up study of ankylosing spondylitis patients; Leukaemierisiko nach intravenoeser {sup 224}Ra-Behandlung - Ergebnisse einer Langzeitstudie an Bechterew-Patienten

    Energy Technology Data Exchange (ETDEWEB)

    Wick, R.R. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenbiologie; Chmelevsky, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Strahlenschutz; Goessner, W. [GSF - Forschungszentrum fuer Umwelt und Gesundheit Neuherberg GmbH, Oberschleissheim (Germany). Inst. fuer Pathologie

    1993-12-31

    In an epidemiological study of the somatic late effects risk following incorporation of a short lived {alpha}-emitter, 1473 ankylosing spondylitis patients treated with repeated intravenous injections of {sup 224}Ra in the years 1948 - 75, have been observed in the GSF. The usual therapeutic plan consisted of a total of 10 - 12 injections of 1.036 MBq (28 {mu}Ci) of {sup 224}Ra each, given at weekly intervals; this would result in an cumulative {alpha}-dose of 0.56 - 0.67 Gy to the marrow-free skeleton of a 70-kg-man (standard man). These patients have been followed together with a control group of ankylosing spondylitis patients not treated with radioactive drugs and/or X-rays. Until May 1993 (mean follow-up time 19.9 yr), 595 patients of the exposure group and 722 patients of the control group have died, causes of death have been ascertained for 578, resp. 668 patients. Among others we observed in the exposure group 10 cases of leukaemia (vs. 2.7 - 2.8 cases expected, p < 0.001) and 6 cases of leukaemia in the control group (vs. 3.3 - 3.5 exp., p = 0.14). Subclassification of the leukaemias shows a clear preference for chronic myeloid leukaemia (CML) in the exposure group (4 cases obs. vs. 0.8 cases exp., p = 0.009), whereas in the control group the observed cases of CML are within the range of expectancy. Similar observations have not been made in another group of patients, now observed by Spiess and co-workers, who have been treated at a higher dose/dose rate range. This increased incidence of leukaemias in our exposure group is in one line with results from animal experiments with bone seeking {alpha}-emitters given at low dose rates. The induction of myeloid leukaemia has been demonstrated in mice down to dose rates of only a few mGy/day also for {sup 239}Pu, an {alpha}-emitter which like {sup 224}Ra deposits preferentially on the bone surface. (orig.) [Deutsch] Im Rahmen einer epidemiologischen Studie zum somatischen Strahlenspaetschadenrisiko nach

  20. Local lysis with Alteplase for the treatment of acute embolic leg ischemia following the use of the Duett {sup trademark} closure device: preliminary results; Lokale Alteplase-Lyse zur Therapie der akuten embolischen Beinischaemie nach Einsatz des Duett {sup trademark} -Verschluss-Systems: vorlaeufige Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Schuermann, K.; Buecker, A.; Wingen, M.; Tacke, J.; Wein, B.; Guenther, R.W. [Klinik fuer Radiologische Diagnostik des Universitaetsklinikums der RWTH Aachen (Germany); Janssens, U. [Medizinische Klinik I (Kardiologie) des Universitaetsklinikums der RWTH Aachen (Germany)

    2004-04-01

    Purpose: To analyze retrospectively the result of the alteplase lysis therapy of embolic complications following the use of the Duett closure device. Methods and Materials: For 3.5 years, the Duett closure device was used in 1,398 angiographies to close the femoral puncture site. The Duett device consists of a balloon and a liquid procoagulant containing collagen and thrombin, which is injected into the puncture tract under endovascular balloon protection of the arterial puncture site. In 9 patients (0.64%), the procoagulant was incidentally injected into the femoral artery causing acute leg ischemia. Eight patients received local lysis therapy with alteplase via a contralateral femoral access. One patient underwent surgery. On average, 21 mg alteplase (4-35 mg) were administered within 14 h (4-21 h). The course of the lysis was followed angiographyically and clinically. All patients were inteerviewed by telephone 23 months (4-35 months) later.Results: In 3 patients, lysis was complete. In 5 patients, only little thrombotic material remained. In all patients, symptoms of ischemia resolved completely within the first hours after initiation of lysis. In 5 cases, bleeding occurred at the puncture site closed with the Duett device during lysis, including development of a false aneurysm in 2 cases. Complications led to premature termination (n=2) or interruption of the lysis (n=3). All complications were treated conservatively. Clinically, long-term sequelae were paresthesia and hypoesthesia in the lower leg and foot in 2 patients treated with lysis, and in the patient who underwent surgery. (orig.) [German] Ziel: Das Ergebnis der Alteplase-Lysetherapie von Embolien nach Einsatz des Duett-Verschluss-Systems wurde retrospektiv untersucht. Methoden: Innerhalb von 3,5 Jahren wurde nach 1398 Angiographien das Duett-System zum Verschluss der femoralen Punktionsstelle eingesetzt. Das System besteht aus einem Ballon und einem fluessigen Prokoagulans (Kollagen, Thrombin), das

  1. Verletzungsschwere und -lokalisationen polytraumatisierter Kinder im Vergleich zu Erwachsenen und deren Bedeutung für das Schockraummanagement

    DEFF Research Database (Denmark)

    Zwingmann, J; Schmal, H; Südkamp, N P

    2008-01-01

    PURPOSE: The treatment of paediatric polytrauma patients in the emergency room is not common. The knowledge of specific injuries in consideration of the age-specific characteristics is of particular importance for precise diagnostics and therapy. The goal of this study is the aquisition of the fr......PURPOSE: The treatment of paediatric polytrauma patients in the emergency room is not common. The knowledge of specific injuries in consideration of the age-specific characteristics is of particular importance for precise diagnostics and therapy. The goal of this study is the aquisition...... of the frequency, the localisation and the severity of paediatric polytrauma (age: 0-16 years) in comparison with adults. PATIENTS AND METHODS: In the period 7 / 01 to 5 / 04 the localisation and injury severity of 23 paediatric polytrauma patients (age: 2-16 years) were compared retrospectivly with those of 324...

  2. Does the risk of plexus brachialis lesion following therapeutic irradiation of the supraclavicular lymph vessels in breast cancer patients persist life-long?; Besteht das Risiko einer radiogenen Plexus brachialis-Laesion nach Strahlentherapie (RT) der supraklavikulaeren Lymphabflusswege bei Brustkrebs-Patientinnen lebeslang?

    Energy Technology Data Exchange (ETDEWEB)

    Rades, D; Bajrovic, A; Fehlauer, F; Tribius, S; Jung, H; Alberti, W [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2004-07-01

    The present analysis shows that the risk of radiogenic plexus brachialis lesion does not decrease but rather remains constant over time. Our series revealed a 2.9% annual rate of newly appearing plexus lesions (p{sub {alpha}}), which is in good agreement with literature data. No significant influence of chemotherapy or tamoxifen treatment on the rate of radiogenic plexus lesions was observed in our series. Within the first five years of radiotherapy (EQD2 59.8 Gy) 3.9% of our patients suffered a lesion of the plexus brachialis. This value is in good keeping with a TD5/5 (5% plexus lesions within 5 years) tolerance dose of 60 - 62 Gy. [German] Die vorliegende Analyse zeigt, dass das Risiko einer radiogenen Plexus-Laesion im Laufe der Zeit nicht abnimmt, sondern konstant bleibt. Die Rate neu aufgetretener Plexus-Laesionen pro Jahr (p{sub a}) von 2,9% in unserer Serie ist mit Daten aus der Literatur vereinbar. Ein signifikanter Einfluss einer Chemotherapie oder einer Tamoxifenbehandlung auf die Rate radiogener Plexus-Laesionen wurde in unserer Serie nicht beobachtet. In den ersten 5 Jahren nach Strahlentherapie (EQD2 59,8 Gy) kam es bei 3,9% unserer Patientinnen zu einer Laesion des Plexus brachialis. Dieser Wert ist gut mit der Toleranzdosis TD5/5 (5% Plexus-Laesionen binnen 5 Jahren) von 60-62 Gy vereinbar. (orig.)

  3. Primary extraparenchymal hemorrhage of the posterior cranal fossa as a premonitory symptom of atlanto-axial instability; Traumatische extraparenchymale Blutung der hinteren Schaedelgrube als Warnsymptom einer atlantoaxialen Instabilitaet

    Energy Technology Data Exchange (ETDEWEB)

    Holl, K.; Rolli, K.; Olschowski, A.; Wurm, G. [Neurochirurgische Abt., Landesnervenklinik Linz (Austria); Nussbaumer, K. [Neuroradiologische Abt., Landesnervenklinik Linz (Austria)

    2001-07-01

    The contribution discusses the cases of five patients with cranio-cerebral trauma, (four children and one adult patient), where CT examination revealed extraparenchymal hemorrhage of the posterior cranal fossa, which did not fit into their pattern of intracranial trauma and therefore gave reason to suspect a lesion of the upper cervical spine. The various types of hemorrhage found are explained, as well as the underlying cervical spine lesions, and the choice of respective therapies which proved to be successful. (orig./CB) [German] Wir berichten ueber fuenf Patienten nach Schaedel-Hirn-Trauma, deren gemeinsamer Befund in der kraniellen Computertomographie eine extraparenchymale Blutung der hinteren Schaedelgrube (HSG) ohne Zusammenhang mit dem uebrigen intrakraniellen Verletzungsmuster bzw. ohne sonstige intrakranielle Verletzung war. Es handelte sich um vier Kinder und einen Erwachsenen mit einem Durchschnittsalter von 8,8 (4-22) Jahren. Drei dieser Patienten wiesen eine epidurale Blutung am Clivus bzw. am Foramen magnum auf, bei einem Patienten handelte es sich um eine Subarachnoidalblutung um das Cerebellum, bei einem weiteren Patienten lag eine Blutung im IV. Ventrikel vor. Diese infratentoriellen Blutungen waren der erste Hinweis, dass eine Verletzung in der oberen Halswirbelsaeule (HWS) vorliegen koennte. Es wurde bei den vier Kindern als zugrundeliegende Ursache der Blutung eine ligamentaere Verletzung C1/C2 diagnostiziert, nur bei dem erwachsenen Patienten lag eine knoecherne Verletzung C1/C2 vor. Die Therapie erfolgte in den vier Faellen mit Instabilitaet chirurgisch, bei dem Patienten ohne Instabilitaet konservativ. Nach einem mittleren Nachbeobachtungszeitraum von 5,2 Jahren waren alle operierten Patienten klinisch gebessert bzw. weiterhin neurologisch unauffaellig. Es konnte bei allen Patienten eine stabile Situation C1/C2 bei guter Funktionalitaet der HWS nachgewiesen werden. (orig.)

  4. Short circuit - How our power supply became more expensive and got worse. A critical balance after eight years ''deregulation'' of the German Energy Economy; Kurzschluss - Wie unsere Stromversorgung teurer und schlechter wurde. Eine kritische Bilanz nach acht Jahren ''Liberalisierung'' der deutschen Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Leuschner, U.

    2007-07-01

    verursachte. Wie Leuschner feststellt, waere der Schaltungsfehler der EON-Netzleitstelle Lehrte vor ein paar Jahren noch vom System toleriert worden. Er habe nur deshalb so gravierende Folgen haben koennen, weil das UCTE-Netz inzwischen durch den Stromhandel und andere Folgen der Deregulierung bis an die Grenzen seiner Kapazitaet belastet sei. Im dritten Teil (''Netznutzung und Netzentgelte'') beleuchtet er in einem zusaetzlichen Kapitel die Bemuehungen der EU-Kommission, doch noch die Rahmenbedingungen fuer echten Wettbewerb herzustellen. Die neueste Forderung der Kommission nach eigentumsmaessiger Entflechtung der Netze deutet er als ''Flucht nach vorn'' angesichts der Tatsache, dass in saemtlichen EU-Laendern seit der Liberalisierung die Strompreise gestiegen sind und das zum Teil sogar ueber die Haelfte (mit der einzigen Ausnahme Englands, und hier auch nur der Haushaltsstrompreise). Kraeftig erweitert hat der Verfasser auch den vierten Teil zum Thema ''Management und Politik'': Zum einen findet man hier nun beschrieben, wie Ex-Bundeskanzler Gerhard Schroeder einen Spitzenjob beim russischen Energiekonzern Gazprom erhielt, dem er bereits in seiner Amtszeit als Bundeskanzler politisch behilflich war, und wie sein ehemaliger Wirtschaftsminister Wolfgang Clement in den Aufsichtsrat von RWE Power einziehen durfte. Zum anderen wird ein kritischer Blick auf die Werbekampagnen geworfen, mit denen die Energiekonzerne versuchen, ihr Erscheinungsbild in der Oeffentlichkeit aufzuhellen und den Energieverbrauchern ein X fuer ein U vorzumachen. (orig.)

  5. Substancinė Dievo formos kaita kaip meninė Visybės reprezentacija (pagal Thomo Manno romaną Juozapas ir jo broliai | Substanziales Werden der Form Gottes als künstleriche Repräsentation des Ganzen (nach der Tetralogie Joseph und seine Brüder von Thomas Mann

    Directory of Open Access Journals (Sweden)

    Juldita Nagliuvienė

    2004-01-01

    Full Text Available Anhand der Polemik zwischen der Totalitätsphänomenologie von Emmanuel Lévinas und der Selbstphänomenologie von Ernst Bloch werden in diesem Artikel die Erscheinungen Gottes, mit denen sich das patriarchalische Subjekt in die Beziehung eingetreten ist, analysiert. Vor allem aktualisiert man den substanziellen Inhalt der künstlerichen Gottesform, deren Wurzeln in der primitiven archaischen Ikonographie der Babylonier und der Ägypter liegen. Das Bild Gottes verwandelt sich in der Situation der Begegnung aus der Substanz des unförmigen Steines, die pfallische Intentionen des Helden akzentuiert, in die symbiotische Form eines Menschentieres (oder Gottes-Tieres, das als Fremde Gott auf der Ebene der Erzählung funktioniert und den Numenaspekt durch die künstliche Form der animalischen Gottheit in sich trägt. Durch die Maske des Tieres strebt der göttliche Begegnungspartner, der das Werden Gottes aktualisiert, nach der Verwandlung in die Gestalt eines sterbenden und wieder auferstehenden Menschen-Gottes, der den sündigen Menschen erlösen kann. In der Tetralogie von Thomas Mann existiert diese Ebene des Nochnicht-gewordenen-Gottes als utopische Stufe der vollkommenen Beziehungen zwischen Mensch und Gott. Die Begegnung zwischen dem tierischen Gott und dem Helden geschieht im Roman in der Traumsphäre, die den Dialog zwischen dem Kunstding und dem Menschen möglich macht. Auf der Traumebene wird der Prozess der Metamorphose einer Gottheit dargestellt, aber sie erscheint als ein schon verwandeltes Wesen, das die Antropomorphie des Erlösungsprinzips aufnimmt, und dem Helden erst im bewussten Zustand begegnet.

  6. Pyrrole and 2,5-heptanedione in the urine of rats and 2,5-heptanedione in the urine of man: analytical determination of excretion upon exposure to n-heptane; Pyrrole und 2,5-Heptandion im Urin der Ratte und 2,5-Heptandion im Urin des Menschen: Analytische Bestimmung der Ausscheidung nach Exposition gegn n-Heptan

    Energy Technology Data Exchange (ETDEWEB)

    Stoermer, A.G.C.

    1997-09-01

    A method for quantifying levels of the neurotoxic metabolite 2,5-heptanedione in rats and man after experimental exposure to n-heptane was developed. It consisted in determining the quantity of 2,5-heptanedione excreted in urine and the relevant excretion kinetics. Moreover, the excretion of pyrrole in the urine of rats was measured. In the urine of non-exposed rats and man, a basic excretion of 2,5-heptanedione was measured, with the rates of excretion being 0.11 and 4.5 nmol per hour, respectively. This basic excretion of 2,5-heptanedione is assumed to have an endogenous cause. The quantitive investigation of the dose dependence of the excretion of 2,5-heptanedione and pyrrole in the urine of rats and of 2,5-heptanedione in the urine of man is a prerequisite for assessing the risk posed by n-heptane with a view to peripheral neuropathies. (orig./MG) [Deutsch] Ziel dieser Arbeit war die Entwicklung einer Methode zur Quantifizierung der Belastung von Ratte und Mensch mit dem neurotoxischen Metaboliten 2,5-Heptandion nach experimentellen Expositionen gegen n-Heptan. Dazu sollte jeweils die ausgeschiedene Menge und die zugehoerige Ausscheidungskinetik von 2,5-Heptandion im Urin bestimmt werden. Darueber hinaus sollte die Ausscheidung von Pyrrolen im Urin von Ratten gemessen werden. Im Urin von nicht exponierten Ratten und Menschen wurde eine Grundausscheidung von 2,5-Heptandion gefunden, wobei die Ausscheidungsraten jeweils 0,11 bzw. 4,5 nmol/h betrugen. Fuer die Grundausscheidung von 2,5-Heptandion wird ein endogener Ursprung angenommen. Die quantitativen Untersuchungen zur Dosisabhaengigkeit der Ausscheidung im Urin von 2,5-Heptandion und Pyrrolen bei der Ratte und von 2,5-Heptandion beim Menschen sind eine Grundvoraussetzung fuer eine Abschaetzung des Risikos von n-Heptan fuer periphere Neuropathien. (orig./MG)

  7. Cognitive Processes (Probably Stimulated By Using Digital Game "Dynamic Metabolic Diagram Virtual Krebs´ Cycle"

    Directory of Open Access Journals (Sweden)

    A. M. P Azevedo

    2006-07-01

    Full Text Available This work describes some of the possible cognitive operations related to the use of an educational game type activity, which  is  part  of  the  software  e-metabolismo,  developed  to  improve  biochemical  learning.  This  interactive  activity, called  DMDV   – Dynamic  Metabolic  Diagram,  allows  participants  to  drag-and-drop  components  of  the  sequence  of chemical  reactions,  which describe  the  metabolic  route  under study.  It  also offers  to the students  quizzes  and texts about  the  subject.  The  suggestion  of  cognitive  processes  possibly  triggered  by  the  software,  which  must  improve effective learning, was based on Jean Piaget’s genetic epistemological ideas to explain the cognitive activity. One of these  processes  is  the  mere  act  of  playing  the  game,  which  Piaget  relates  to  humans  needs  of  learning  rules  of socialization.  It  also  can  be  seen  as  a  first  step  in  cognition  process,  the  so  called  adaptation  function  that  include assimilation and accommodation, interactive processes between intelligent activities and elements from the reality, to became part of the individual´s mental structures. Another example: drag and drop substracts and enzymes pieces in a  virtual  board,  each  one  corresponding  to  an  specific  place  in  a  metabolic  route.  This  operation  can  be  related  to motivation,  an  affective  element  proposed  by  Piaget  to  stimulate  curiosity  and  improve  construction  of  knowledge structures.  Besides  this  issue,  the  act  of  choosing  pieces  is  assumed  to  inform  the  student  previous  knowledge (previous  cognitive  structures,  which,  according  to  Piaget,  must  be  misbalanced  (equilibration  of  new  structures  is supposed to be part of the dynamic process of organization of new knowledge. DMDV was tested with a group of 24 students  (2003  and  another  group  of  36  students  in  2004,  of  a  Biochemistry  Course  regularly  registered  at FFFMCPA´s medicine  faculty.  The  evaluation  of the student’s apprenticeship  was  made  by a  conventional  test  and three Conceptual Maps constructed by each student, (a before playing the game, (b immediately after, and (c three months after the use of the game.

  8. Delayed effects of carcinoma in childhood or adolescence; Spaetfolgen von Krebs im Kindes- und Jugendalter

    Energy Technology Data Exchange (ETDEWEB)

    Scholz-Kreisel, Peter; Blettner, Maria [Universitaetsmedizin der Mainz Univ. (Germany). Inst. fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI)

    2016-08-01

    Due to advances in diagnostics and therapy the survival rate and survival time of juvenile oncologic patients have increased during the last years. About 80% of these patients survive 15 years after diagnosis, dependent on localization, status and some other factors. With increasing survival probability the many questions concerning delayed effects of disease and therapy arise. Especially cardiac and vascular side effects seem to be predominant. The PanCare network (Pan-European network for care of survivors after childhood and adolescent cancer) has evoked several research projects.

  9. Cortical blindness after intoxication with heroin; Kortikale Blindheit nach Heroinintoxikation

    Energy Technology Data Exchange (ETDEWEB)

    Braendli, M. [Institut fuer Diagnostische Radiologie, Universitaetskliniken, Kantonspital Basel (Switzerland); Otte, A.; Mueller-Brand, J. [Institut fuer Nuklearmedizin, Universitaetskliniken, Kantonspital Basel (Switzerland)

    2000-07-01

    For the case reported, both morphological and functional diagnostic examination methods were applied, such as MRI and CT, or SPECT using ECD as a tracer. The bilateral, occipital lesion finally could be detected with the SPECT examinations, and SPECT findings were clearly better than MRI findings, whereas even restrospective analysis of the CT images failed to show the lesion. Thus the functional imaging method in this case of a discrete bilateral occipital lesion was the most sentitive method. (orig./CB) [German] In unserem Fallbeispiel wurden sowohl morphologische (MRT, CT) als auch funktionelle Bildgebung (SPECT unter Verwendung von ECD als Tracer) ad extensum zur Diagnosefindung verwendet. Die bilaterale okzipitale Defektbildung konnte schliesslich mittels SPECT-Untersuchung deutlich besser dargestellt werden als mittels MRT. In der CT gelangte der Befund - auch bei retrospektiver Betrachtung - ueberhaupt nicht zur Darstellung. Damit war die funktionelle Bildgebung im Falle dieser diskreten bilateralen okzipitalen Defektbildung die sensitivste Methode. (orig.)

  10. Nach dem Deutschstudium in Afrika wird man – was? Eine ...

    African Journals Online (AJOL)

    This paper reports on an investigation of the value of German Studies in eventual employment of students in this field. The objectives of German Studies in Africa have to include an indication of how inclusion in the curriculum is legitimized. Three approaches towards legitimization have developed since the establishment of ...

  11. Political strategies concerning technological development after Chernobyl. Technologiepolitik nach Tschernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Soeldner-Rembold, S [ed.

    1986-01-01

    The twelve contributions compiled in this book are intended to show political as well as technological conclusions to be drawn from the Chernobyl reactor accident. The material presented stands up to the arguments put forward by the nuclear lobbyists, and explains reasons calling for a nuclear shut-down, backing out of the fast breeder reactor technology and of the fusion technology. Brown coal is stated to be the energy source of choice.

  12. Follow the sun - solar tracking; Immer der Sonne nach

    Energy Technology Data Exchange (ETDEWEB)

    Winter, Fred

    2013-10-01

    The new personal use solar system MSS of Deger Energie (Horb am Neckar, Germany) allows a wide autonomy in the power supply. For commercial customers too. [German] Das neue Solarsystem MSS (Maximum Solar Speicher) von Deger Energie in Horb am Neckar erlaubt weitgehende Autonomie in der Stromversorgung. Auch fuer Gewerbekunden.

  13. Quantenfische die Stringtheorie und die Suche nach Weltformel

    CERN Document Server

    Lüst, Dieter

    2011-01-01

    Lässt sich das Verhalten aller Dinge, von den kleinsten Teilchen bis zum Universum, einheitlich beschreiben? Der heißeste Kandidat für die Entwicklung einer Weltformel, die alle physikalischen Phänomene erklären kann, ist die Stringtheorie. Sollte sie sich als richtig erweisen, so würde das unser Verständnis über den Ursprung der Naturgesetze dramatisch verändern. Denn das von uns beobachtete Universum wäre dann vermutlich eine winzige Blase in einem viel größeren Gebilde, dem Multiversum. Um die Stringtheorie und die Idee des Multiversums plausibel zu machen, greift der international bekannte theoretische Physiker Dieter Lüst auf ein Modell zurück: das Leben von Fischen in einem Teich. Eines Tages gelingt es den Fischen, die kleinsten Teilchen zu identifizieren, aus denen alles im Fischteich besteht - eingeschlossen sie selbst. Sie nennen diese Urbausteine Quantenfische, da ihr Verhalten nahelegt, dass sie auch eine Art von Lebewesen sind. Doch der ersten folgt eine weitere Entdeckung der Fisch...

  14. Das Stefan-Problem bei der Kristallzucht nach Czochralski

    OpenAIRE

    Kopetsch, H.

    1987-01-01

    The shape of the crystal-melt interface in Czochralski crystal growth may strongly influence the quality of the grown crystal. Thus a numerical algorithm has been developed which allows us to study the dynamics of this interface subject to various growth conditions. Especially the hydrodynamics in the melt is taken into account. Mathematically, a moving boundary problem (Stefan problem) has to be solved along with the flow and temperature field in melt and crystal which is treated by the meth...

  15. Uber das Gravitationsfeld eines Massenpunktes nach der Einstenschen Theorie

    OpenAIRE

    Bel, Ll.

    2007-01-01

    Schwarzschild's solution of Einstein's field equations in vacuum can be written in many different forms. Unfortunately Schwarzschild's own original form is less nice looking and simple than that latter derived by Droste and Hilbert. We prove here that we can have both: a nice looking simple form and the meaning that Schwarzschild wanted to give to his solution, i.e., that of describing the gravitational field of a massive point particle.

  16. Developmental effects of prenatal irradiation. Entwicklungsstoerungen nach praenataler Bestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Kriegel, H; Schmahl, W; Kistner, G; Stieve, F E

    1982-01-01

    This book is the result of a symposium which was organised jointly by the WHO and the department for nuclear biology of the Gesellschaft fuer Strahlen- und Umweltforschung (Society for Radiation- and Environmental Research) Neuherberg; the Institut fuer Strahlenhygiene (Institute for Radiation Hygiene) of the Federal Board of Health (Bundesgesundheitsamt), Neuherberg and the working group ''Radiation Biology'' in the ''Deutsche Roentgengesellschaft'' and took place in Neuherberg near Munich from the 26.-28. November 1980. Subjects dealt with the lectures were: Developmental disturbances caused by prenatal exposure to either external radiation or incorporation of radionuclides in the organism of the mother. Based on the prenatal radiation effects already known new experiences and new knowledge were reported on and show new consequences on peri- and postnatal development. Radiation effects of incorporated radionuclides include also questions of the biokinetics of radioactive substances at present the emphasis lies on diaplacental penetration. Questions of synergetic effects of radiation and diaplacentally penetrating chemical substances were discussed on the symposium as well. These subjects were also extensively dealt with in a panel discussion.

  17. Menschewiken in Stockholm vor und nach 1917 / Alexander Kan

    Index Scriptorium Estoniae

    Kan, Alexander

    2005-01-01

    Rootsi sisserännanud menševikest ja bolševikest, nende koostööst rootsi sotsiaaldemokraatidega, vene revolutsionääride tagasipöördumisest Venemaale Veebruarirevolutsiooni järel, repatrieerujaid toetanud Abikomitee tegevusest

  18. Nach dem Deutschstudium in Afrika wird man – was? Eine ...

    African Journals Online (AJOL)

    Eva Hamann. 196. 2. Die Legitimierungsdebatte. Die Debatte um die Legitimierung und Relevanz des Studienfachs Deutsch in Afrika, geführt von afrikanischen Auslandsgermanisten, spiegelt sich ab den 80er Jahren in afrikanischen. Periodika wie Études Germano-Africaines und in deutschen Periodika wie Jahrbuch DaF.

  19. Pandava laminata, eine weitere nach Deutschland importierte Spinnenart (Araneae: Titanoecidae

    Directory of Open Access Journals (Sweden)

    Jäger, Peter

    2008-12-01

    Full Text Available Pandava laminata (Thorell, 1878 was recorded for the first time from Germany at the Cologne Zoo. The species was most likely introduced with plants or cargo from Southeast Asia. Characters important for identification at species, genus and family level are listed and partly illustrated.

  20. Kuttenberger Dekret nach 600 Jahren. Eine Bilanz der bisherigen Forschung

    Czech Academy of Sciences Publication Activity Database

    Nodl, Martin; Šmahel, František

    2009-01-01

    Roč. 49, č. 1 (2009), s. 19-54 ISSN 0323-0562 R&D Projects: GA AV ČR(CZ) IAA800090901 Institutional research plan: CEZ:AV0Z90090514 Keywords : Bohemia * Prague * the Charles University * colleges * Quodlibet Disputation 1409 * Czech Reform movement * the Kuná Hora Decree * nationalism Subject RIV: AA - Philosophy ; Religion

  1. Complications following surgery and adjuvant irradiation in rectal carcinoma. Komplikationen nach Operation und nach adjuvanter Bestrahlung beim Rektumkarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Suhr, P.; Limmer, J. (Ulm Univ. (Germany, F.R.). Universitaetsklinikum)

    1991-04-12

    Colorectal cancer is one of the most common human malignancies. Adjuvant irradiation can decrease the risk of recurrence and subsequently the associated morbidity compared with surgery alone. The rate of radiation-induced complications amounts to approximately 10%, which is substantially lower than the frequency of observed local failure. (orig.).

  2. Distanzen überwinden: Über das Potenzial audio-visueller e-Tandems für den Deutschunterricht von Erwachsenen in Kolumbien

    Directory of Open Access Journals (Sweden)

    Yasmin El-Hariri

    2015-04-01

    Full Text Available Sprachenlernen im Tandem ist eine Methode, bei der zwei Lernende mit unterschiedlichen Sprachen von- und miteinander lernen. Die wachsende Verfügbarkeit elektronischer Medien ermöglicht solche Kooperationen heutzutage auch über große Distanzen (e-Tandem. Der vorliegende Beitrag präsentiert Ergebnisse einer im August/September 2014 durchgeführten Onlinebefragung unter Deutschlernenden in Kolumbien. Ziel dieser Befragung war es, Sprachlerneinstellungen von Lernenden, deren Beweggründe für die Wahl von DaF sowie Erwartungshaltungen hinsichtlich e-Tandems zu erheben. Die Ergebnisse zeigen prinzipiell ein hohes Potenzial dieser Lernform, geben jedoch auch Hinweise auf in der Planung und Durchführung besonders zu beachtende Aspekte, die für eine gelungene Umsetzung unabdingbar sind.   Tandem language learning is a method which involves two learners with different languages learning from and with each other. The growing availability of electronic media nowadays allows such co-operation across long distances (e-Tandem. The present contribution presents results of an online survey conducted in August/September 2014 among learners of German in Colombia. The aim of this survey was to determine the learners' attitudes towards language learning, their motivation to choose German as a foreign language, as well as their expectations regarding e-Tandem language learning. Results show a high potential of such a learning approach; however, they also indicate crucial aspects which have to be considered specifically during implementation in order to develop the full potential of the method.

  3. 3 tesla magnetic resonance imaging in children and adults with congenital heart disease; 3-Tesla-Magnetresonanztomographie zur Untersuchung von Kindern und Erwachsenen mit angeborenen Herzfehlern

    Energy Technology Data Exchange (ETDEWEB)

    Voges, I.; Hart, C.; Kramer, H.H.; Rickers, C. [Universitaetsklinikum Schleswig-Holstein, Klinik fuer angeborene Herzfehler und Kinderkardiologie, Kiel (Germany); Jerosch-Herold, M. [Harvard Medical School, Department of Radiology, Brigham and Women' s Hospital, Boston (United States); Helle, M. [Universitaetsklinikum Schleswig-Holstein, Institut fuer Neuroradiologie, Kiel (Germany)

    2010-09-15

    Cardiovascular magnetic resonance imaging (CMR) has become a routinely used imaging modality for congenital heart disease. A CMR examination allows the assessment of thoracic anatomy, global and regional cardiac function, blood flow in the great vessels and myocardial viability and perfusion. In the clinical routine cardiovascular MRI is mostly performed at field strengths of 1.5 Tesla (T). Recently, magnetic resonance systems operating at a field strengths of 3 T became clinically available and can also be used for cardiovascular MRI. The main advantage of CMR at 3 T is the gain in the signal-to-noise ratio resulting in improved image quality and/or allowing higher acquisition speed. Several further differences compared to MRI systems with lower field strengths have to be considered for practical applications. This article describes the impact of CMR at 3 T in patients with congenital heart disease by meanings of methodical considerations and case studies. (orig.) [German] Die kardiovaskulaere Magnetresonanztomographie (MRT) hat sich zu einer etablierten bildgebenden Methode zur Untersuchung von Patienten mit angeborenen Herzfehlern entwickelt. Sie erlaubt in einer einzigen Untersuchung die exakte Beurteilung von Anatomie, globaler und regionaler Funktion, Blutfluessen sowie der myokardialen Perfusion und Vitalitaet. In der klinischen Routine erfolgen die Untersuchungen zumeist bei einer Feldstaerke von 1,5 Tesla (T), mittlerweile gibt es jedoch Geraete und Bildgebungstechniken, die die kardiovaskulaere MRT auch bei 3 T ermoeglichen. Der wesentliche Vorteil der MRT bei 3 T ist das hoehere Signal-zu-Rausch-Verhaeltnis, das sowohl zu einer Verbesserung der Bildqualitaet als auch zu einer Verkuerzung der Untersuchungszeit genutzt werden kann. Darueber hinaus bestehen verschiedene andere Unterschiede gegenueber Systemen mit niedriger Feldstaerke, die im praktischen Einsatz beachtet werden muessen. Dieser Artikel beschreibt die Erfahrungen der 3-T-MRT fuer die Untersuchung von Patienten mit angeborenen Herzfehlern anhand methodischer Betrachtungen und Beispiele. (orig.)

  4. Pediatric cardiology. Clinical and practical experiences with heart diseases of children, juveniles and young adults; Kinderkardiologie. Klinik und Praxis der Herzerkrankungen bei Kindern, Jugendlichen und jungen Erwachsenen

    Energy Technology Data Exchange (ETDEWEB)

    Haas, Nikolaus A. [Herz- und Diabeteszentrum NRW, Bad Oeynhausen (Germany). Klinik fuer angeborene Herzfehler; Kleideiter, Ulrich [Klinik fuer Kinder- und Jugendmedizin, Coesfeld (Germany)

    2011-07-01

    The book on pediatric cardiology covers the following chapters: (I) Fundamentals and diagnostics: pediatric cardiologic anamnesis, electrocardiograms, thorax X-radiography, MRT and CT of the heart, nuclear medical diagnostics, exercise tests, heart catheter examination, electrophysiological tests. (II) Leading symptoms: Cyanosis, cardiac murmur, thorax pain, palpitation, syncopes. (III) Disease pictures: congenital heart defects, acquired heart defects, cardiomyopathies, heart rhythm disturbances, heart insufficiency, arterial hypertension, pulmonary hypertension, other heart involving syndromes. (IV) Therapy: Catheter interventional therapy, post-surgical pediatric cardiac therapy, surgery involving the life-support machine, mechanical cardiovascular support systems, initial treatment of newborns with critical heart defects, heart transplantation, vaccination of children with heart diseases, medicinal therapy.

  5. Dosisabhängiger Anstieg von Knochenformatinsmarkern in Serum und Knochen unter Zink-Supplementation - eine Untersuchung an der erwachsenen weiblichen Maus

    Directory of Open Access Journals (Sweden)

    Dimai H-P

    1998-01-01

    Full Text Available Zink (Zn ist eine essentielles Spurenelement. Es spielt eine wichtige Rolle in zahlreichen metabolischen Prozessen und wird auch für das normale Knochenwachstum benötigt. Ziel der vorliegenden Untersuchung war es, den Effekt von Zn auf a die Aktivität der alkalischen Phosphatase (ALP in Serum und Knochen, b das Serum-Osteocalcin, c die Tartrat-resistente saure Phosphatase (TRAP im Knochen, sowie d den Protein-Gehalt des Knochens darzustellen. Erwachsene weibliche Swiss-Webster-Mäuse erhielten entweder eine Zn-freie Diät, oder eine Diät, welche einen normalen, oder einen 2-, 3-, 4-, oder 5-fach höheren Zn-Gehalt als die Normal-Diät hatte. Die Diät wurde für 2, 4, oder 6 Wochen verabreicht. Es zeigte sich eine positive Korrelation zwischen der Menge des mit der Nahrung aufgenommenen Zn und der Serum-ALP (4 und 6 Wochen, p 0,001, der tibialen ALP (2, 4 und 6 Wochen, p  0,03, sowie dem tibialen Protein (2,4 und 6 Wochen p 0.001; weiters zeigte sich eine negative Korrelation zwischen Zn und tibialer TRAP (2, 4 und 6 Wochen, p 0,001. Kovarianzanalysen zeigten überdies, daß die Aktivität der Serum-ALP, der tibialen ALP und der tibialen TRAP, sowie die Menge des tibialen Proteins sowohl durch die Zn-Dosis (p 0,005, als auch die Dauer der Therapie (p 0,03 beeinflußbar sind. Zn zeigte auch einen signifikanten Einfluß auf den Serum-Osteocalcin-Spiegel (p 0,03 bei 3 x höher Zn-Menge als in der Normaldiät. In einer ergänzenden Studie zeigte sich auch, daß Zn zu einem dosisabhängigen Anstieg der ALP und des Proteins, und zu einem signifikanten Abfall der TRAP in murinen osteoblastenähnlichen MC3T3-E1 Zellen führt. Insgesamt kann aus den Ergebnissen der vorliegenden Studie geschlossen werden, daß eine schrittweise Erhöhung des Zn-Gehaltes der Nahrung zu einem entsprechenden Anstieg der ALP-Aktivität von Serum und Knochen führt. Da in dieser Studie klar gezeigt werden konnte, daß Zn auch zu einem Abfall der TRAP-Aktivität in osteoblastenähnlichen Zellen führt, sollte künftighin ein Absinken der TRAP-Aktivität im Knochen nicht als Zeichen einer Knochenresorptions-Hemmung interpretiert werden.

  6. Wirkungen eines Bifidojoghurts mit Laktulose und eines konventionellen Joghurts auf Darmphysiologie und bakterielle Metaboliten als Risikomodulatoren der Kolonkarzinogenese sowie Darmflora und Blutlipide bei gesunden Erwachsenen

    OpenAIRE

    Gerlach, Stefanie

    2007-01-01

    Hintergrund: Probiotische und synbiotische Milchprodukte zählen zu den "funktionellen Lebensmitteln", denen im Vergleich zu herkömmlichen Produkten ein gesundheitsfördernder Zusatznutzen zugeschrieben wird. Dabei wird diskutiert, ob die Gesundheit bereits gesunder Personen noch optimierbar ist, ob und in welcher Weise die Darmflora gezielt "günstig" modifiziert werden kann und/oder ob diese Manipulation zu messbaren gesundheitsfördernden Veränderungen metabolischer und systemischer Biomarker ...

  7. Gerbstoffe aus Potentilla officinalis wirken entzündungshemmend im UV-Erythem-Test und bei Anwendung auf atopischer Haut.

    Science.gov (United States)

    Hoffmann, Julia; Wölfle, Ute; Schempp, Christoph M; Casetti, Federica

    2016-09-01

    Das Rhizom von Potentilla officinalis (PO) ist reich an Gerbstoffen und wird traditionell zur äußerlichen Behandlung von Entzündungen der Haut und der Schleimhäute verwendet. Ziel der vorliegenden Arbeit war die Bestätigung der antiinflammatorischen Eigenschaften von PO mittels eines UV-Erythem-Tests und einer klinischen Anwendungsstudie bei atopischer Haut. Die antiinflammatorische Wirkung eines PO-Extrakts (standardisiert auf 2 % Trockensubstanz) wurde in einer prospektiven, randomisierten, placebokontrollierten Doppelblindstudie mit 40 gesunden Erwachsenen im UV-Erythem-Test im Vergleich zu 1 % Hydrocortisonacetat untersucht. Im Rahmen einer prospektiven nicht kontrollierten Studie wurde die Wirkung und Verträglichkeit der 2 % PO-Creme an zwölf Erwachsenen und zwölf Kindern mit atopischer Haut nach Anwendung über zwei Wochen in einem definierten Testareal anhand eines Teil-SCORAD untersucht. Zusätzlich wurde die Beeinflussung der Hautrötung im Testareal photometrisch gemessen. Im UV-Erythem-Test zeigte die PO-Creme eine signifikante Reduktion des Erythemindex im Vergleich zum Vehikel. Die antiinflammatorische Wirkung des Verums entsprach der der 1 % Hydrocortisonacetat-Creme. Die klinische Studie bei Atopikern zeigte eine signifikante Abnahme des Teil-SCORAD und des Erythems im Testareal. Es wurden keine Unverträglichkeitsreaktionen beobachtet. PO als 2%ige Zubereitung besitzt entzündungshemmende Eigenschaften und ist wirksam und gut verträglich auf atopischer Haut. © 2016 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  8. Der Unterricht zur Arzt-Patientin-Beziehung (APB im Fach Medizinische Soziologie an den medizinischen Fakultäten der Bundesrepublik Deutschland nach Änderung der Approbationsordnung für ��rzte [Teaching the doctor-patient relationship in medical sociology within German medical faculties following revisions to licensing regulations for physicians

    Directory of Open Access Journals (Sweden)

    Kiessling, Claudia

    2008-11-01

    well as to make it more multifaceted. [german] Hintergrund: Die 2002 eingeführte neue Ärztliche Approbationsordnung (ÄAppO löste in der Fachgesellschaft Deutsche Gesellschaft für Medizinische Soziologie e.V. (DGMS eine vielschichtige Diskussion aus. Um den Prozess der curricularen Verständigung zu forcieren, wurde von der AG Lehre der DGMS eine Befragung zum Thema Arzt-Patientin-Beziehung im medizinsoziologischen Unterricht durchgeführt. Methode: Die Befragung fand im Frühjahr 2005 per E-Mail statt. Instrument war ein standardisierter Fragebogen mit insgesamt dreißig Lernzielen, welche nach fünf Kriterien beurteilt werden sollten. Insgesamt 13 ExpertInnen aus Instituten der Medizinischen Soziologie an elf Medizinischen Fakultäten antworteten auf die Befragung. Die Daten wurden EDV-gestützt erfasst. In Anlehnung an die für Delphiverfahren empfohlenen Methoden wurden arithmetische Mittel und Streuungsmaße berechnet. Ergebnisse: Von den insgesamt dreißig Lernzielen wurden zwei von der Majorität der Befragten negativ beurteilt. Zwanzig weitere zeigten Beurteilungsvarianzen. Acht Lernziele, wie die soziale Rahmung der Arzt-Patientin-Beziehung, die elaborierte Sprache oder auch die Asymmetrie der Arzt-Patientin-Beziehung, wurden kollektiv positiv eingeschätzt. Bei den Lernzielen mit Beurteilungsvarianzen werden Widersprüche sichtbar. Bei einigen Lernzielen, wie etwa der Erhebung einer Sozialanamnese, klaffen erkannte Relevanz und praktische Umsetzung auseinander. Schlussfolgerungen: Die Ergebnisse bezüglich der gegenwärtigen Lehrpraxis zum Thema Arzt-Patientin-Beziehung an elf Medizinischen Fakultäten geben Orientierungen für weiterführende Diskussionen in der Medizinischen Soziologie. Zum einen führen die Antwortquote und die Diskussionspraxis der letzten Jahre zu der Schlussfolgerung, dass die Diskussion in der Fachgesellschaft über den Kreis der Fachvertreter resp. der langjährig in der Lehre Tätigen hinaus geführt werden sollte. Zum anderen

  9. Glycolytic pathway (GP), kreb's cycle (KC), and hexose monophosphate shunt (HMS) activity in myocardial subcellular fractions exposed to cannabinoids

    International Nuclear Information System (INIS)

    Watson, A.T.; Manno, B.R.; King, J.W.; Fowler, M.R.; Dempsey, C.A.; Manno, J.E.

    1986-01-01

    Delta-9-tetrahydrocannabinol (Δ 9 -THC), the primary psychoactive component of marihuana, and its active metabolite 11-hydroxy-Δ 9 -tetrahydrocannabinol (11-OH-Δ 9 -THC) have been reported to produce a direct cardiac depressant effect. Studies in isolated perfused rat hearts have indicated a decreased force of contraction (inotropic response) when Δ 9 -THC or 11-OH-Δ 9 -THC was administered in microgram amounts. The mechanism and site of action have not been explained or correlated with associated metabolic pathways. The purpose of this study was to investigate the effects of cannabinoids on major myocardial energy producing pathways, GP and KC, and a non-energy producing pathway, HMS. Cardiac ventricular tissue from male Sprague-Dawley rats (250-300 g) was excised and homogenized for subcellular fractionation. KC, GP and HMS activity was assayed in the appropriate fractions by measuring 14 CO 2 generation from 14 C-2-pyruvate, 14 C-6-glucose and 14 C-1-glucose respectively. Duplicate assays (n=8) were performed on tissue exposed to saline (control), empty liposomes (vehicle) and four doses each of Δ 9 -THC and 11-OH-Δ 9 -THC. Changes in metabolic activity and decreases in cardiac contractile performance may be associated

  10. Krebs cycle metabolite profiling for identification and stratification of pheochromocytomas/paragangliomas due to succinate dehydrogenase deficiency

    NARCIS (Netherlands)

    Richter, S; Peitzsch, M.; Rapizzi, E.; Lenders, J.W.M.; Qin, N.; Cubas, A.A. de; Schiavi, F.; Rao, J.U.; Beuschlein, F.; Quinkler, M.; Timmers, H.J.L.M.; Opocher, G.; Mannelli, M.; Pacak, K.; Robledo, M.; Eisenhofer, G.

    2014-01-01

    CONTEXT: Mutations of succinate dehydrogenase A/B/C/D genes (SDHx) increase susceptibility to development of pheochromocytomas and paragangliomas (PPGLs), with particularly high rates of malignancy associated with SDHB mutations. OBJECTIVE: We assessed whether altered succinate dehydrogenase

  11. Medulloblastoma in adults. A retrospective single institution analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hadi, Indrawati; Roengvoraphoj, Olarn; Niyazi, Maximilian; Nachbichler, Silke Birgit [LMU Munich, Department of Radiation Oncology, University Hospital, Munich (Germany); Roeder, Falk [LMU Munich, Department of Radiation Oncology, University Hospital, Munich (Germany); German Cancer Research Center (DKFZ), Molecular Radiation Oncology, Heidelberg (Germany); Schueller, Ulrich [University Medical Center, Institute of Neuropathology, Hamburg-Eppendorf (Germany); Research Institute Children' s Cancer Center, Hamburg (Germany); University Medical Center, Department of Pediatric Hematology and Oncology, Hamburg-Eppendorf (Germany); Belka, Claus [LMU Munich, Department of Radiation Oncology, University Hospital, Munich (Germany); German Cancer Consortium (DKTK), Munich (Germany)

    2018-03-15

    multimodale Therapie in unserer Einrichtung erhalten haben. Die Akten aller Patienten mit De-novo-Medulloblastomen, die aelter als 15 Jahre waren und in unserer Einrichtung zwischen 2001 und 2014 behandelt wurden, wurden retrospektiv ausgewertet. Demographische Parameter, initiale Symptome, Behandlungsmodalitaeten, Toxizitaeten und Ueberlebensresultate wurden untersucht. Insgesamt wurden 21 Patienten mit einem medianen Alter von 30,2 Jahren identifiziert. Die haeufigsten Histologien waren desmoplastisch und klassisch, der vorherrschende molekulare Subtyp war ''sonic hedgehog'' (SHH). Nach der Tumorresektion erhielten alle Patienten eine kraniospinale Bestrahlung (mediane Dosis 35,2 Gy) und einen Boost auf die hintere Schaedelgrube (mediane Dosis 19,8 Gy). Eine simultane Chemotherapie mit Vincristin erhielten 20 Patienten, eine sequentielle Chemotherapie 15 Patienten. Die haeufigsten Nebenwirkungen waren haematologische Toxizitaeten. Das mediane Gesamtueberleben (OS) wurde nach einer medianen Nachbeobachtungszeit von 92 Monaten nicht erreicht. Das geschaetzte 5- und 10-Jahres-OS war 89 und 80 %. Das geschaetzte progressionsfreie 5- und 10-Jahres-Ueberleben (PFS) betrug 89 und 81 %. In der univariaten Analyse war ein kuerzeres Intervall zwischen Tumorresektion und Ende der Bestrahlung signifikant assoziiert mit besserem OS und PFS, eine anaplastische Histologie mit einem schlechteren OS und PFS. Die multimodale Behandlung zeigte ein gutes Ergebnis bei Erwachsenen mit Medulloblastomen. Nachdem sich die Behandlungsdauer als prognostisch relevant herausstellte, sollte sie so kurz als moeglich gehalten werden. (orig.)

  12. Konservierung der männlichen Fertilität - Klinische und experimentelle Methoden

    Directory of Open Access Journals (Sweden)

    Gassei K

    2009-01-01

    Full Text Available Gängige Therapieansätze zur Behandlung von Krebserkrankungen können die Spermatogenese auf unterschiedlichsten Wegen stören und zu temporärer Azoospermie oder Sterilität führen. Die Unfruchtbarkeit ist eine ernstzunehmende Langzeitnebenwirkung, die die Lebensqualität des Patienten nachhaltig einschränken kann. Bei Kinderwunsch nach erfolgreicher Krebstherapie steht erwachsenen Patienten heute eine Anzahl an assistierten Reproduktionstechniken (ART wie In-vitro-Fertilisation (IVF oder Intrazytoplasmatischer Spermieninjektion (ICSI zur Verfügung, die mithilfe von kryokonservierten Spermien durchgeführt werden können. Diese Methoden können jedoch die natürliche Fertilität des Patienten nicht wiederherstellen und sind für präpubertäre Krebspatienten ungeeignet, da diese vor Beginn der Chemo- oder Radiotherapie keine Samenprobe liefern können. Die Transplantation von testikulären Stammzellen bietet daher einen möglichen Therapieansatz zur Behandlung von Unfruchtbarkeit. Methoden zur Isolierung, Konservierung, Transplantation und In-vitro-Maturierung dieser Zellen befinden sich zur Zeit in der Entwicklung. Der vorliegende Beitrag diskutiert etablierte Methoden zur Fertilitätskonservierung bei Männern und gibt darüber hinaus einen Überblick über die neuesten Forschungsergebnisse zur Keimzelltransplantation und extrakorporalen Generierung von Keimzellen.

  13. Inflammatory diseases of the orbit; Entzuendungen der Orbita

    Energy Technology Data Exchange (ETDEWEB)

    Zimmer, A.; Reith, W. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg (Germany)

    2008-12-15

    Inflammatory conditions belong to the most important diseases of the orbit. Children and adolescents are mostly affected and the most common cause is secondary pathogen invasion from acute sinusitis. However in adults most cases involve idiopathic orbital inflammation, previously termed pseudotumor orbitae. Clinical presentation may include painful exophthalmus, skin redness and warming, chemosis and disturbed eye motility. The challenge for imaging investigations, mainly a combination of CT scanning and MRI, is to distinguish inflammatory from malignant conditions, to define the extent of lesions and to document possible complications, such as cavernous sinus thrombosis, meningoencephalitis or cerebral abscesses. Serious potential consequences of orbital infections, including loss of vision or death, are still a risk factor and must be averted by avoidance of delays in diagnosis and appropriate clinical management. (orig.) [German] Entzuendliche Veraenderungen zaehlen zu den wichtigen Erkrankungen der Orbita. Meist sind Kinder und Jugendliche betroffen, wobei eine fortgeleitete Infektion der Nasennebenhoehlen die haeufigste Ursache darstellt. Bei Erwachsenen handelt es sich in den meisten Faellen um eine idiopathische Orbitaentzuendung - frueher unter dem Begriff Pseudotumor orbitae zusammengefasst. Zu den Leitsymptomen zaehlen schmerzhafter Exophthalmus, Ueberwaermung und Roetung der Haut, Chemosis sowie eine Bewegungseinschraenkung des Bulbus. Die Rolle bildgebender Verfahren - hier ergaenzen sich Computer- und Magnetresonanztomographie - besteht in der Differenzierung inflammatorischer und tumoroeser Prozesse und insbesondere in der Darstellung der Laesionsausdehnung sowie dem Nachweis von Komplikationen, wie einer Sinus-cavernosus-Thrombose, einer Meningoenzephalitis oder zerebralen Abszessen. Auch heute noch koennen Infektionen der Orbita schwerwiegende Folgen wie komplette Erblindung oder Tod nach sich ziehen. (orig.)

  14. Rehabilitation of deaf persons with cochlear implants; Rehabilitation Hoergeschaedigter mit Cochlearimplantaten

    Energy Technology Data Exchange (ETDEWEB)

    Gstoettner, W.; Hamzavi, J. [Universitaetsklinik fuer Hals-Nasen-Ohrenheilkunde, Wien (Austria); Czerny, C. [Universitaetsklinik fuer Radiologie, Wien (Austria)

    1997-12-01

    In the last decade, the rehabilitation of postlingually deaf adults and prelingually deaf children with cochlear implants has been established as a treatment of deafness. The technological development of the implant devices and improvement of the surgical technique have led to a considerable increase of hearing performance during the last years. The postlingually deaf adults are able to use the telephone and may be integrated in their original job. Prelingually deaf children can even visit normal schools after cochlear implantation and hearing rehabilitation training. In order to preoperatively establish the state of the cochlear, radiological diagnosis of the temporal bone is necessary. High resolution computerized tomography imaging of the temporal bone with coronar and axial 1 mm slices and MRI with thin slice technique (three dimensional, T2 weighted turbo-spinecho sequence with 0.7 mm slices) have proved to be valuable according to our experience. Furthermore a postoperative synoptical X-ray, in a modified Chausse III projection, offers good information about the position of the implant and insertion of the stimulating electrode into the cochlea. (orig.) [Deutsch] In der letzten Dekade hat sich der operative Einsatz von Cochlearimplantaten fuer die Rehabilitation taubgeborener Kinder und ertaubter Erwachsenen als erfolgreiche Therapie etabliert. Durch technische Weiterentwicklung der Implantatsysteme und Verbesserung der Operationstechnik konnten in den letzten Jahren die Hoerleistungen der Patienten deutlich verbessert werden. Postlingual ertaubte Erwachsene koennen nun oftmals wieder ins Berufsleben eingegliedert werden und praelingual ertaubte Kinder koennen regulaere Schulen besuchen. Im Rahmen der Voruntersuchung fuer die Cochlearimplantation ist die radiologische Felsenbeindiagnostik von besonderer Bedeutung. Hochaufloesendes CT des Felsenbeins in koronaren und axialen Ebenen mit 1 mm Schichtdicke und MRT in Duennschichttechnik (dreidimensionale, T2

  15. Daily atom - a guide after Chernobyl. 60 days after Chernobyl. Taegliches Atom - Ein Ratgeber fuer die Zeit nach Tschernobyl. 60 Tage nach Tschernobyl

    Energy Technology Data Exchange (ETDEWEB)

    1986-01-01

    There a first group of several contributions on basic know-ledge about radioactivity such as: a primer of nuclear physics, doses, reactor types, measuring instruments. The second group is concerned with the Chernobyl accident, the spread of contamination and tips for reducing the personal radiation burden. The third group is concerned with the Wackersdorf reprocessing plant and the energy policy sparing nuclear energy. No specific author names are given for the particular contributions. 16 refs., 32 figs., 16 tabs. (qui).

  16. Nuclear catastrophes and their consequences. 30 years after Chernobyl, 5 years after Fukushima; Nukleare Katastrophen und ihre Folgen. 30 Jahre nach Tschernobyl, 5 Jahre nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Liebert, Wolfgang; Gepp, Christian; Reinberger, David (eds.)

    2016-07-01

    The book on nuclear catastrophes covers the following issues: A historical oversight on nuclear power; two catastrophic reactor accidents: Chernobyl and Fukushima; presentation of important experiences on the radiological consequences of the severe accidents; regulatory reactions in Europe as a consequence of Fukushima; beyond Chernobyl and Fukushima: fundamental problems with nuclear energy.

  17. Analysis of image acquisition, post-processing and documentation in adolescents with spine injuries. Comparison before and after referral to a university hospital; Bildgebung bei wirbelsaeulenverletzten Kindern und jungen Erwachsenen. Eine Analyse von Umfeld, Standards und Wiederholungsuntersuchungen bei Patientenverlegungen

    Energy Technology Data Exchange (ETDEWEB)

    Lemburg, S.P.; Roggenland, D.; Nicolas, V.; Heyer, C.M. [Berufsgenossenschaftliches Universitaetsklinikum Bergmannshell, Bochum (Germany). Inst. fuer Diagnostische Radiologie, Interventionelle Radiologie und Nuklearmedizin

    2012-09-15

    Purpose: Systematic evaluation of imaging situation and standards in acute spinal injuries of adolescents. Materials and Methods: Retrospective analysis of imaging studies of transferred adolescents with spinal injuries and survey of transferring hospitals (TH) with respect to the availability of modalities and radiological expertise and post-processing and documentation of CT studies were performed. Repetitions of imaging studies and cumulative effective dose (CED) were noted. Results: 33 of 43 patients (77 %) treated in our hospital (MA 17.2 years, 52 % male) and 25 of 32 TH (78 %) were evaluated. 24-hr availability of conventional radiography and CT was present in 96 % and 92 % of TH, whereas MRI was available in only 36 %. In 64 % of TH, imaging expertise was guaranteed by an on-staff radiologist. During off-hours radiological service was provided on an on-call basis in 56 % of TH. Neuroradiologic and pediatric radiology expertise was not available in 44 % and 60 % of TH, respectively. CT imaging including post-processing and documentation matched our standards in 36 % and 32 % of cases. The repetition rate of CT studies was 39 % (CED 116.08 mSv). Conclusion: With frequent CT repetitions, two-thirds of re-examined patients revealed a different clinical estimation of trauma severity and insufficient CT quality as possible causes for re-examination. A standardization of initial clinical evaluation and CT imaging could possibly reduce the need for repeat examinations. (orig.)

  18. CT-morphological characterization of respiratory syncytial virus (RSV) pneumonia in immune-compromised adults; Morphologische Charakterisierung und Verlaufsbeurteilung von Respiratory Syncytial Virus (RSV) Pneumonien bei immunkompromittierten Erwachsenen in der Thorax-CT

    Energy Technology Data Exchange (ETDEWEB)

    Mayer, J.L.; Kauczor, H.U. [Univ. Hospital Heidelberg (Germany). Diagnostic and Interventional Radiology; Lehners, N.; Egerer, G. [Univ. Hospital Heidelberg (Germany). Internal Medicine V of Hematology, Oncoloy and Rheumatology; Heussel, C.P. [Thoracic Hospital at Univ. Hospital Heidelberg (Germany). Diagnostic and Interventional Radiology with Nuclear Medicine

    2014-07-15

    Characterization and follow-up evaluation of chest CT of RSV pneumonia in immune-compromised adults during a seasonal epidemic. Retrospective analysis of 132 chest CT examinations of 51 adult immune-compromised patients (29 m/22f, diameter 58 years) with clinical signs of pneumonia and positive RSV test in winter 2011/2012. Two experienced chest radiologists evaluated the morphology (bronchial wall thickening, tree-in-bud, nodules, halo, ground-glass opacities, consolidations, pleural fluid) of the CT scans by consensus. Pathological findings were in 86 % of the chest CT scans: Areas of ground-glass attenuation in 64 %, consolidations in 56 %, nodules in 55 % (diameter 8 mm in maximal diameter, with halo in 71 %), pleural fluid in 44 % (diameter 2 cm), tree-in-bud in 36 %, bronchial wall thickening in 27 % and more than one morphological finding in 72 %. There were no pathological CT findings in 14 % of patients with clinical symptoms of pneumonia because these patients did not undergo follow-up. Radiological progression was found in 45 % of patients and regression in 33 % in follow-up examinations. In 37 % an additional examination of the paranasal sinuses was performed and showed sinusitis in 63 % of cases. 90 % of the patients had sinusitis as well as pneumonia. In addition to RSV, a further pathogenic agent was found in bronchoalveolar lavage of five patients (Aspergillus spec., herpes simplex virus, Pseudomonas aeruginosa). The most characteristic signs in chest CT scans were at the beginning of pneumonia with nodules and tree-in-bud often combined with bronchial wall thickening. The following CT scans showed characteristic but not pathognomonic chest CT findings of RSV pneumonia. These morphological findings should be recognized seasonally (winter) especially at the beginning of the case of pneumonia. RSV-associated additional sinusitis is probably common and should be noticed.

  19. Alles Banane? Fiktionale Erinnerung an DDR und Wende in den ersten zwanzig Jahren nach dem Mauerfall

    NARCIS (Netherlands)

    Maczka, Iwona Maria

    2010-01-01

    How are the GDR and the fall of the Berlin Wall remembered? The dissertation “Alles Banane?” deals with this question. It assumes that identity, individual as well as collective, is a social, cultural and political construction based on the memory of the past. This construction is not only

  20. Neues Punktionsinstrumentarium: Provox-Vega®-Punktionsset: Anwendung beim Einbringen einer Stimmprothese nach Laryngektomie

    NARCIS (Netherlands)

    Lorenz, K.J.; Hilgers, F.M.; Maier, H.

    2013-01-01

    Background The use of voice prostheses has been considered the gold standard in voice rehabilitation following laryngectomy for the last 20 years. Insertion is generally performed as a primary procedure during laryngectomy or as a secondary procedure with a re-usable trocar or rigid esophagoscope, a

  1. Zur Identifikation einer nach Deutschland eingeschleppten Kammspinnenart (Araneae: Ctenidae: Phoneutria boliviensis

    Directory of Open Access Journals (Sweden)

    Jäger, Peter

    2009-12-01

    Full Text Available Data and a drawing of the epigyne of Phoneutria boliviensis (F.O. Pickard-Cambridge, 1897, recently recorded from Germany, are presented. The specimen was introduced with cargo (bananas from Brazil. Characters of the single female are illustrated to facilitate identification in the future, since in the two recent revisions of the genus no drawing of the epigyne of P. boliviensis was included. Another case of introduction from 1998 of an unidentified subadult Phoneutria specimen, probably P. boliviensis too, with bananas from Ecuador is documented.

  2. Long-term results after primary infrapopliteal angioplasty for limb ischemia; Langzeitergebnisse nach Ballonangioplastie kruraler Arterien

    Energy Technology Data Exchange (ETDEWEB)

    Alfke, H. [Klinikum Luedenscheid (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Vannucchi, A. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Froelich, J.J. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Klinikum Bad Hersfeld (Germany). Klinik fuer Radiologie und Nuklearmedizin; El-Sheik, M.; Wagner, H.J. [Marburg Univ. (Germany). Klinik fuer Strahlendiagnostik; Vivantes-Klinikum im Friedrichshain (Germany). Inst. fuer Radiologie und Interventionelle Therapie

    2007-08-15

    Purpose: To evaluate the technical success rate, procedure-related complications, and clinical long-term results for patients who underwent infrapopliteal angioplasty. Materials and Methods: We retrospectively evaluated all patients who underwent infrapopliteal angioplasty to treat critical chronic limb ischemia or severe claudication from 1/1997 to 12/1999. We excluded patients with acute (< 2 weeks) limb ischemia. Procedure-related data were prospectively documented in a database and analyzed with a focus on the technical success rate and procedure-related complications. In addition all clinical documents were analyzed, and a follow-up examination was performed or telephone interviews were conducted with patients, relatives and referring doctors for follow-up. The primary end points were the limb salvage rate and patient survival rate. The secondary end points included the complication rate, technical success rate, and walking distance. Results: 112 patients with a mean age of 72 years (41 women, 71 men) underwent crural angioplasty on 121 limbs. Four patients suffered from severe claudication (Rutherford category 3) and all others had critical chronic limb ischemia (category 4 to 6). The complication rate was 2.7 %. The technical success rate was 92 %. The ankle brachial index increased from 0.59 to 0.88. The mean walking distance increased significantly from 52 {+-} 66 to 284 {+-} 346 meters at the time of follow-up. The limb salvage rate was 83.6 % after one year and 81.1 % after three years. The mean survival rate according to Kaplan-Meier was 79.4 %, 69.2 %, and 54.2 % at 1, 2, and 3 years, respectively. Patients with at least one patent run-off vessel after angioplasty had a significantly better limb salvage rate. Diabetes was not a risk factor for limb salvage. Conclusion: Infrapopliteal angioplasty shows a high technical success rate with an acceptable complication rate. The clinical long-term success seems favorable if a least one open run-off vessel was able to be achieved. However, the survival rate was limited by the co-morbidity in this patient group. (orig.)

  3. Alexander von Humboldt brachte Guano nach Europa - mit ungeahnten globalen Folgen

    Directory of Open Access Journals (Sweden)

    Bärbel Rott

    2016-05-01

    Full Text Available Zusammenfassung Die vorliegende Abhandlung beschäftigt sich mit einem bisher wenig beachteten Aspekt von Humboldts Amerikanischer Reise (1799─1804. Während seine Studien der Pflanzen- und Tierwelt bis heute große Aufmerksamkeit genießen, wird Humboldts Beitrag zu der Entwicklung der modernen Landwirtschaft wenig beachtet. Während seines Aufenthalts in Lima erhielt er Proben von Guano, Vogelmist von den Chincha-Inseln vor der peruanischen Küste. Einige Proben, die er von dieser Reise zurückbrachte, wurden von Wissenschaftlern in Frankreich und Deutschland untersucht. Die Analysenergebnisse zeigten außerordentlich hohe Gehalte an Pflanzennährstoffen, insbesondere Stickstoff und Phosphor. In den folgenden Jahrzehnten wurde Guano zu einem bedeutsamen Düngemittel und Auslöser eines Booms in Europa und Peru. Die Auswirkungen dieser Entwicklung sind bis heute sichtbar und werden hier unter besonderer Beachtung von Phosphor beschrieben. Abstract One aspect of Humboldt’s travel to South America (1799─1804 received little attention. The fascination of his studies of the South American flora and fauna is unbroken to the present day. Yet Humboldt’s contribution to modern agriculture remains almost unnoticed. During his stay in Lima Humboldt received samples of guano, a mixture of bird droppings from the Chincha Islands off the Peruvian coast, which he took to Europe and had analyzed by the most famous chemists in France and Germany. The results showed outstanding fertilizing effects, in particular due to the high content of nitrogen and phosphorus. The ensuing boom starting from the 1840s influenced agriculture in Europe and the economy of Peru seriously. Some aspects of this historical development may give an idea of the ensuing change not only in agriculture. Résumé Il y a un aspect du voyage de Alexander von Humboldt en Amérique du Sud (1799─1804 qui jusqu’à présent a été peu considéré. Ses études de la flore at le da faune de l’Amérique du Sud ont attiré une large attention du public. Or, son influence au développement de l´agriculture moderne est plutôt ignoré. Pendant son séjour à Lima, Humboldt reçut des échantillons de guano qui est composé des excréments d’oiseaux des Iles Chincha face à la côte du Pérou. Humboldt les faisait examiner par des scientifiques français et allemands. Les résultats des analyses montraient des teneurs extraordinaires de nutriments pour plantes, en particulier d´azote et de phosphore. Pendant les décennies suivantes le guano devenait une source indispensable comme fertilisant et a créé un boom en Europe et au Pérou. L’impact de ce développement qui est perceptible jusqu’à nos jours est décrit ci-dessous.

  4. Never let me go : ein Drehbuch nach dem gleichnamigen Roman von Kazuo Ishiguro

    OpenAIRE

    Wendel, Johann

    2011-01-01

    By their very existence, adaptations remind us there is no such thing as an autonomous text or an original genius transcending history, either public or private. They also affirm, however, that this is not to be lamented. - Linda Hutcheon, A Theory of Adaptation (2006) 1 Einführung Adaptionen - ob sie auf einer Literaturvorlage, einem Zeitungsbericht oder einem historischen Ereignis basieren - sind in der heutigen Filmindustrie eher die Regel als die Ausnahme: so waren laut eine...

  5. The work of Leslie Valiant: alle die Strassen führen nach Strassen

    Directory of Open Access Journals (Sweden)

    J. Andrés Montoya

    2014-12-01

    Full Text Available . This year Leslie VALIANT becomes sixty five years old; we celebrate his fest with this work in which we analyze some of his major achievements. We focus our attention on those of his works for which a strong influence of Volker Strassen can be easily detected. Strassen’s work has had a strong and lasting influence on Valiant. It does not means, as the title could suggest, that the manyfaced, relevant and complex work of Leslie Valiant can be understood as a corollary to Strassen. Resumen. Este año Leslie VALIANT cumple 65 años y nosotros queremos celebrar este importante aniversario con este trabajo en el que se analiza su obra. Centramos nuestra atención en aquellos de sus trabajos en los que una clara influencia de Volker STRASSEN puede ser detectada. Es patente la influencia de Strassen en la obra de Valiant, pero esto no quiere decir que el trabajo de Valiant, complejo y multifacético, sea un simple corolario a la obra del primero.

  6. Similarities and Differences Between Yoruba Traditional Healers (YTH) and Native American and Canadian Healers (NACH).

    Science.gov (United States)

    Adekson, Mary Olufunmilayo

    2016-10-01

    Indigenous people of the world have used the services of medicine men and traditional healers from time immemorial. According to the World Health Organization, 80 % of the world's populations consult traditional healers. With an emerging globalization of health services in the world, there is a need for western mental health practitioners to learn and understand the practices of indigenous healers across the globe. This paper will not only highlight the similarities and differences between Yoruba traditional healers of Western Nigeria and Native American and First Nation Canadian traditional healers, but it will also allow practitioners to gain clearer perspectives of indigenous clients from Yoruba land and those from the United States of America and Canada. This ultimately will inform culturally sensitive clinical practice with these populations.

  7. Evaluation of underexposed conventional radiographs after digitization. Auswertung fehlbelichteter konventioneller Roentgenaufnahmen nach Digitalisierung

    Energy Technology Data Exchange (ETDEWEB)

    Wenz, W. (Freiburg Univ. (Germany). Abt. Roentgendiagnostik); Buitrago-Tellez, C. (Freiburg Univ. (Germany). Abt. Roentgendiagnostik); Moenig, H. (Freiburg Univ. (Germany). Inst. fuer Biophysik und Strahlenbiologie); Niemeier, R. (Digital Diagnostik Deutschland GmbH, Freiburg im Breisgau (Germany))

    1993-02-01

    Inadequate exposure of analogue radiographs is reported in the literature to occur in 5-25% of cases. Therefore, the present study was performed to test whether selective image processing after digitization could reveal diagnostic details on underexposed radiographs. In addition, the minimal exposure values required for diagnostic purposes after adequate image processing were studied. Phantom studies, organ preparations and measurements of physical parameters with decreasing exposure values were performed. The detection of anatomic and pathologic (nondisplaced fracture lines, microcalcification and renal stones) structures were evaluated by 12 readers. Radiographs with exposure values 20-40% lower than 'ideal' values can provide adequate diagnostic images after digital processing. The diagnostic information is significantly impaired with values under 50% of the correct exposure values. In conclusion, this method is adequate to save underexposed radiographs for diagnostic purposes and to avoid repeated examinations. (orig.)

  8. Der Wiederaufbau Narvas nach 1944 und die Utopie der "sozialistischen Stadt" / Karsten Brüggemann

    Index Scriptorium Estoniae

    Brüggemann, Karsten, 1965-

    2004-01-01

    Nõukoguliku arhitektuuripoliitika põhimõtetest, "sotsialistliku linna" teoreetilisest ideaalist ja selle ideaali praktilisest teostusest Narvas. Narva vanalinna saatusest. 1944. aastal asuti vana Narva kohale rajama sisuliselt uut linna, Narva ehitamist mõjutas eelkõige asjaolu, et seal sai alguse uraanitootmine NSV Liidus

  9. Looking for the super battery; Suche nach dem Super-Akku

    Energy Technology Data Exchange (ETDEWEB)

    Janzing, Bernward

    2010-09-15

    Germany used to be a leading country in electric battery technology. Today, it is far behind Asia. This may change as the new research center at Ulm starts working. The focus of the institution will be on lithium ion accumulator batteries for electric-powered vehicles. (orig.)

  10. Die Entstehung einer Nachbarsegmentdekompensation nach lumbaler Spondylodese. Einfluß des sagitalen Profils

    OpenAIRE

    Noe, Stephan

    2003-01-01

    Die vorliegende Arbeit beschäftigt sich mit der Frage, ob ein Zusammenhang zwischen der frühen Dekompensation einer Nachbaretage neben einem fusioniertem Bandscheibensegment im Lendenwirbelsäulenbereich und dem sagittalen Profil der Lendenwirbelsäule besteht. Im Rahmen der Untersuchungen wurden in einer retrospektiven Untersuchung die Krankenakten und Röntgenbilder von 51 Patienten der Zentralkliniken Bad Berka (Wirbelsäulenchirurgie) und Patienten der Orthopädischen Klinik des Universitä...

  11. Bees trace the effects of the air traffic; Bienen spueren Folgen des Luftverkehrs nach

    Energy Technology Data Exchange (ETDEWEB)

    Waeber, Monica [UMW Umweltmonitoring, Muenchen (Germany); Hergt, Volker [Flughafen Muenchen GmbH, Muenchen (Germany)

    2011-04-15

    The honey-monitoring at the Munich Airport addresses the question of whether the operation of a major airport affects the contamination of food produced in the neighborhood. Since 2008, honey, pollen and beeswax are tested for residues of metals and polycyclic aromatic hydrocarbons.

  12. Prospektive Entwicklung des postoperativen Sprachverstehens nach Tympanoplastik bei chronischer Otitis media

    OpenAIRE

    Knof, B; Plotz, K; Krack, A; Stumper, J; Schönfeld, R

    2013-01-01

    Einleitung: Tympanoplastiken I/III bei chron. Otitis media COM (mesotympanalis CMOM und epitympanalis CEOM). In der Literatur werden erfolgreiche operative Behandlungen mit Verringerung der Schallleitungskomponente (air-bone gap) belegt (Gierke et al. 2011). Aus Sicht des Patienten steht die Verbesserung des Hörvermögens und des Sprachverstehens im Alltag im Vordergrund. Das Ziel war die Untersuchung der Entwicklung des Hörvermögens in Ruhe sowie im Störgeräusch.Methoden: An den Hör- und Sp...

  13. Nachrichten aus Amerika oder wie man in Koblenz von Humboldts Reise nach Amerika erfuhr

    Directory of Open Access Journals (Sweden)

    Franz-J. Weihrauch

    2006-04-01

    Full Text Available Article in German, Abstracts in English and German.In the almost forgotten Jacobinic newspaper “Der Bewohner des West Rheins” (i.e. The Citizen of the Western Rhine, published in Koblenz/Rhine there appeared on Brumaire 29th of the year IX (i.e. November 20th 1800 a summary of a letter dated January 24th, 1800, sent by Alexander von Humboldt from Laguaira, Venezuela to his colleague Antoine François de Fourcroy (1755-1809 in Paris. It takes Humboldt’s letter six months to reach the French capital and further four months later it arrives in the (at that time French province of the departements on the left bank of the Rhine. This up to now unknown publication of a a letter by Humboldt in the newspaper “Der Bewohner des West Rheins”, a paper of only regional significance, vividly shows two parallel developments: on the one hand the spreading of knowledge from the centre to the perifery, from the capital to the province and on the other hand the spreading of knowledge from the already highly specialized scientific network to the general newspaper business that “generates” publicity and popularizes knowledge.

  14. Antisemitismus, Shoah und deutsche Verantwortung:(Nach)Wirkungen des Nationalsozialismus im medialen Nahostdiskurs

    OpenAIRE

    Ullrich, Peter

    2010-01-01

    Wahrscheinlich wird kein anderer internationaler Konflikt derart kontrovers und emotional in der bundesrepublikanischen Öffentlichkeit sowie auch und gerade in der politischen Linken diskutiert wie der israelisch-palästinensische oder weiter gefasst, der Nahost-Konflikt. Aus diesem Grund nimmt dieses Thema einen besonderen Platz in der Bildungsarbeit der Rosa-Luxemburg- Stiftung im Inland wie im Ausland ein. Wenngleich dabei auch in der Stiftung und ihrem Umfeld die Meinungen auseinandergehen...

  15. Nach der Genderforschung ist vor der Genderforschung“ – oder?

    Directory of Open Access Journals (Sweden)

    Barbara Scholand

    2008-11-01

    Full Text Available Der Frage, ob die Kategorie ‚Gender‘ ausgedient hat oder weiter ertragreich genutzt werden kann, stellen sich die Autorinnen und Autoren des Bandes in einem von Erziehungswissenschaftler/-innen veranstalteten „Interdisziplinären Gespräch“. Eine Bestandsaufnahme der feministischen Theoriebildung wird vorgenommen und – durchaus vorhandene – neue Perspektiven werden aufgezeigt und diskutiert. Ein spezifisch erziehungswissenschaftliches Profil im Kontrast zu den Beiträgen aus Soziologie, Philosophie, Politikwissenschaft und Geschichte wird allerdings nicht deutlich.

  16. "Doing pupil" nach Schulschluss – Videografie an einer Kinderuniversität

    Directory of Open Access Journals (Sweden)

    Alexandra König

    2015-03-01

    Full Text Available Auf der Basis einer Videografie an einer Kinderuniversität wird in dem vorliegenden Beitrag die Frage verfolgt, wie an einem außerschulischen Lernort generationale Ordnung hergestellt wird und welche Gestalt diese annimmt. Als heuristischer Rahmen dient das Modell der "Sozialisation als generationales Ordnen" (BÜHLER-NIEDERBERGER 2011; BÜHLER-NIEDERBERGER & TÜRKYILMAZ 2014. Die Analyse der ersten Sitzungen von zwei kontrastiven Kursen an der Kinder- und Jugenduniversität zeigt erstens, wie Kinder struktursensitiv Regeln in dem unbekannten Kontext erspüren, erarbeiten und modifizieren, wie sie KomplizInnen in der Herstellung generationaler Ordnung sind. Zweitens wird die Dominanz der schulischen Ordnung und des SchülerInnenstatus für Kindheit deutlich. Die Kinder stellen "Schule" her – paradoxerweise auch in einem außerschulischen Kontext. Drittens wird im kontrastiven Vergleich der untersuchten Kurse eine Varianz dieser Ordnungen – in Bezug auf die Form des Wissens und Adressierung der Kinder – herausgearbeitet, die allerdings die Dominanz der schulischen Ordnung nicht bricht. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs150263

  17. Postoperative imaging of knee, hip and shoulder arthroplasty; Postoperative Bildgebung nach Gelenkersatz. Knie, Huefte, Schulter

    Energy Technology Data Exchange (ETDEWEB)

    Saupe, Nadja; Zanetti, Marco [Klinik Hirslanden, Zuerich (Switzerland). Zentrum fuer Muskuloskelettale Radiologie; Romero, Jose [Endoclinic Zuerich (Switzerland). Knie-Chirurgische Kompetenz-Praxis; Hersche, Otmar [Klinik Hirslanden, Zuerich (Switzerland). Endoclinic

    2017-12-15

    Numerous joint prostheses are used in orthopedic practice. This article reviews the current status of knee, hip and shoulder replacement and the expected radiographic appearances. Different types and techniques of replacement, various designs of hardware, the imaging appearance of complications of replacement and of revisions will be discussed. This article will also acknowledge some of the basic principles to reduce metal-induced susceptibility artifacts originate in MR images. Common ways to reduce or modify artifacts will be presented too.

  18. Life after Chernobyl. Radiation burden - radiation effects - risks. Leben nach Tschernobyl. Belastung - Wirkung - Risiko

    Energy Technology Data Exchange (ETDEWEB)

    Haury, H J; Ullmann, C

    1986-01-01

    The book is intended to help dissolving the feelings of helplessness and discomfiture among the population, by providing the information needed to avoid unnecessary worries, and to take the right decisions. The authors have collected the scientific knowledge available today of radioactive radiation and its effects on the biological environment and the human body. Taking into account the measured data and other insight obtained from previous accidents like the one at Seveso, e.g., or from the atmospheric nuclear weapons tests and the resulting fallout, the authors present advice and proposals that have been weighed with a view to a reasonable risk-benefit relation. The authors think that a well-informed person can today assess his own personal radiation risk after careful consideration of personal habits, and keep the radiation burden as low as possible. Apart from the variety of practical hints and advice given, the authors also discuss the confusion created by officials and authorities through their meager information policy, which finally led to the credibility gap in public opinion. The book is completed by an annex containing a survey of the Atomic Energy Laws, the Radiation Protection Ordinance, resolutions of the Strahlenschutzkommission (SSK), a literature index, and a comprehensive subject index.

  19. Suche nach solaren Axionen mit dem CCD-Detektor in CAST (CERN Axion Solar Telescope)

    CERN Document Server

    Kang, Donghwa

    2007-01-01

    The CERN Axion Solar Telescope (CAST) experiment at CERN searches for solar axions with energies in the keV range. Axions could be produced in the Sun's core by the interaction of thermal photons with virtual photons of the strong electromagnetic field. In this experiment, the solar axions can be converted to photons in the field of a 9 Tesla superconducting magnet. At both ends of the 10 m long dipole magnet, three different X-ray detectors were installed, which are sensitive in the interesting photon energy range. This thesis is devoted to the determination of an upper limit on the axion-photon coupling constant g$_{a\\gamma}$. The analysis is based on the data taken by the CCD detector in the CAST experiment during the years 2003 and 2004. First results of the 2003 data taking were published showing no significant signal above background. However, these results constrain the upper limit of the axion-photon coupling constant by a factor 5 compared to previous axion search experiments. Moreover, the result of...

  20. Ordnungspolitische Fragen zur Unternehmenspublizität nach der Enron-Insolvenz

    OpenAIRE

    Zimmermann, Jochen

    2002-01-01

    Am 2. Dezember 2001 hat der US-amerikanische Energiehändler Enron Insolvenz angemeldet. Für viele völlig überraschend brach das an der Börsennotierung gemessen vormals siebtgrößte Unternehmen der USA zusammen. Welche ordnungspolitischen Lehren sind für die Publizität und Rechnungslegung von Unternehmen aus dem Fall Enron zu ziehen?

  1. After Chernobyl. Is oblivion reigning again. Nach Tschernobyl. Regiert wieder das Vergessen

    Energy Technology Data Exchange (ETDEWEB)

    Wirth, H.J. (Giessen Univ. (Germany, F.R.). Zentrum fuer Psychosomatische Medizin) (ed.)

    1989-09-01

    The Chernobyl accident mobilized profound anxieties in many people, which subsequently were repressed again and played down with the aid of the known psychological mechanisms. The authors trace the anxiety, and the resistance against it, and pose the question of whether we are at all capable of learning to think along new lines. From the contents: 10 theses on Chernobyl 1986 (Anders, G.); Anxiety, apathy and new thinking (Richter, H.-E.); On the Germans' particular way of dealing with existential threats (Wirth, H.-J.); Appeasement and delusion - small and big flights from powerlessness (Leithaeuser, T.); Socio-psychological theses on the consequences of nuclear energy (Clemenz, M.); Psychological arguments in the discussion about Chernobyl (Kettner, M.); Relationship between fear and technology (Brede, K.); Inhumanity of technology (Spangenberg, N.); Psychology of nuclear addiction (Bauriedl, T.); Nature or technology - search of the wizard's apprentice for lost salvation (Bastian, T./Hilger, M.); Living under a nuclear threat - significance of existential fear experienced during childhood (Boehnke, K., et al.); Survey of, and psychoanalytical reflections on, poisoned childhood (Petri, H.); On knowing, feeling, and experience after Chernobyl (Thiel, W.); Sociopsychological aspects of the staging of politics as a state spectacle fit for the media (Fuechner, H.). (orig./HP).

  2. Steueroptimierte Alters- und Berufsunfähigkeitsvorsorge nach dem Alterseinkünftegesetz

    OpenAIRE

    Eberhardt, Michael G.

    2007-01-01

    Eine höhere Lebenserwartung bei gleichzeitiger Überalterung der deutschen Gesellschaft sind maßgebliche Gründe eines heute bereits festzustellenden Defizits der gesetzlichen Rentenversicherung. Die jüngste Rentenreform mit dem Altersvermögens- und Alterseinkünftegesetz setzte deshalb maßgebliche Anreize, die Alterssicherung eigenverantwortlich um eine private, staatlich geförderte Vorsorge zu ergänzen. Jedoch mangelt es derzeit vorwiegend an einer fachkundigen Informations- und Beratungsleist...

  3. Frieden durch Ineffizienz? Die Reform der US Cyberwar Strategie nach den Snowden-Leaks

    OpenAIRE

    Schmetz, Martin

    2013-01-01

    Es tut sich etwas in Folge der Snowden-Leaks: In den USA werden Untersuchungsausschüsse eingesetzt, Vorstöße, die Macht der NSA einzuschränken bzw.transparenter zu gestalten werden stärker – vor allem aber wird es wohl institutionelle Änderungen geben. Und diese hängen an einer Person: Keith Alexander.

  4. Functional MRI of the cervical spine after distortion injury; MR-Funktionsdiagnostik der Halswirbelsaeule nach Schleudertrauma

    Energy Technology Data Exchange (ETDEWEB)

    Schnarkowski, P. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Weidenmaier, W. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Heuck, A. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Reiser, M.F. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik

    1995-04-01

    50 patients with a history of distortion injury of the cervical spine were examined with static and functional MRI. Functional MRI consisted of different patient`s positions from maximal extension to maximal flexion (30 , 0 , 25 , 40 , 50 ). T{sub 2}*-weighted gradient echo sequences were performed in a sagittal view for the different positions. Ligamentous instabilities and disc protrusions were seen only in functional MRI in 17 patients. These findings correlated with the neurological symptoms. Two patients were treated by operative fusion because of these findings. (orig.) [Deutsch] Bei 50 Patienten mit einem Schleudertrauma der Halswirbelsaeule wurden zu den statischen Magnetresonanztomogrammen der Halswirbelsaeule MR-Funktionsaufnahmen durchgefuehrt. Diese Funktionsaufnahmen erfolgten in 5 verschiedenen Flexionsgraden von maximaler Reklination bis zur maximalen Inklination (30 , 0 , 25 , 40 , 50 ). T{sub 2}*-gewichtete Gradienten-Echo-Sequenzen in sagittaler Schnittfuehrung wurden fuer jeden Flexionsgrad angefertigt. Bandinstabilitaeten und Bandscheibenvorwoelbungen konnten bei 17 Patienten nur in bestimmten Flexionsgraden erfasst werden. Diese 17 Patienten zeigten eine umschriebene neurologische Symptomatik, die von ihrer Lokalisation mit den in der MR-Funktionsdiagnostik erhobenen Befunden korrelierten. Zwei Patienten wurden aufgrund diese Befunde mit einer operativen Fusion therapiert. (orig.)

  5. Hunde stabilisieren das Selbst : Fragen nach der psychischen Funktion eines Haustiers

    OpenAIRE

    Hartmann, Maike

    2008-01-01

    The development of the questionnaire "The dog as a selfobject" is represented in this Diploma thesis. It is based on self-evaluated data and it is shown in the form of a fourstaged Likert-Scale. The important issues were calculated with a factor analysis. The five main scales are:"selfobject in generally" , "disadvantages through the dog" , "dog as bonding catalysists" , "education of the dog" and "Idealization of the dog".The conceptualization und operationalization are based on the literatu...

  6. Peace in the year 2000. Frieden 2000. Fragen nach Sicherheit und Glauben

    Energy Technology Data Exchange (ETDEWEB)

    Gollwitzer, H.

    1982-01-01

    The author appeals to theology in general to take up responsibility for the fate of mankind, and he does so in a manner full of fantasy, encouraging people to become politically active. This book is manual full of standfast and thoughtful hints for pedagogics in peace.

  7. Was kommt nach dem Handel? Umnutzung von Einzelhandelsflächen und deren Beitrag zur Stadtentwicklung

    OpenAIRE

    Sperle, Tilman

    2012-01-01

    In der Stadt europäischen Typs sind Stadt und Handel eng miteinander verwoben. Die Bedeutung des Handels geht weit über dessen originäre Versorgungsfunktion hinaus. Für die städtischen Zentren und Nebenzentren übernimmt er sowohl gestaltende als auch soziale Funktionen und trägt mit seiner belebenden Wirkung maßgeblich zum urbanen Leben bei. Mit dem tief greifenden Strukturwandel im Einzelhandel verändert sich diese Beziehung zwischen Stadt und Handel dramatisch, Trading-down-Prozesse geh...

  8. Auf der Suche nach historischen Phrasemen – oder: Wörterbücher als Korpora

    Directory of Open Access Journals (Sweden)

    Dräger, Marcel

    2009-01-01

    Full Text Available The treatment of phrasemes is problematic both in a lexicographic view and a corpus analytic view, even though the efforts of the collocation research provide enormous amounts of output. Finding and automatically extracting phrasemes, that are longer than two or three word collocations, is still not satisfactorily possible, because there are no markers in the text, that indicate the borders of the expressions. If in addition the perspective is an historical one, the problems arise as the amount of available historical texts decreases. For an historical phraseographic analysis realistic examples are extremely help- and needful, so that other sources for assembling examples have to be found. The following text proposes some approaches, how dictionaries can be used as corpora, and shows, which results (examples, illustrations, links etc. can be expected. The point of origin of the idea is to use dictionaries not in the classical way – that means: searching the headword and reading the related article –, but to use the whole dictionary as a corpus. This inverse use of dictionaries allows us to find a lot of implicit lexikographic information, that in a normal way of using dictionaries could only be found by coincident.

  9. Oberflächenveränderung verschiedener zahnmedizinischer Werk-stoffe nach in-vitro Alterung

    OpenAIRE

    Kuster, Daniela

    2014-01-01

    Susceptibility of different restorative materials to toothbrush abrasion and coffee staining Objective: The aim of this study was to evaluate the susceptibility of different restorative materials to surface alterations after an aging simulation. Methods: Specimens (n=15 per material) of five different restorative materials (CER: ceramic/Vita Mark II; EMP: composite/Empress Direct; LAV: CAD/CAM composite/Lava Ultimate; COM: prefabricated composite/Componeer; VEN: prefabricated composite/...

  10. The search for Dark Matter in our galaxy; Suche nach Dunkler Materie in unserer Galaxie

    Energy Technology Data Exchange (ETDEWEB)

    Eitel, K. [Forschungszentrum Karlsruhe GmbH Technik und Umwelt (Germany). Inst. fuer Kernphysik; Boer, W. de [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Experimentelle Kernphysik

    2007-07-01

    The matter content in galaxies like the Milky Way as well as in the entire Universe is dominated by Dark Matter (DM). The nature of this DM is one of the great enigmas of modern astroparticle physics. A promising candidate for this DM is a weakly interacting massive particle (WIMP). DM can then be detected directly via rare elastic collisions of WIMPs with atomic nuclei in a well shielded underground detector or via the decay products from the annihilation of two WIMPs. Energetic gamma rays in cosmic radiation might therefore indicate an indirect signal of DM particles in our galaxy. We present two experimental approaches to search for WIMP Dark Matter. (orig.)

  11. Randschicht- und durchgreifendes Härten von 42CrMo4 nach CVD-Beschichtung

    DEFF Research Database (Denmark)

    Pantleon, Karen; Kessler, Olaf; Hoffmann, Franz

    1999-01-01

    the properties of steel substrates ready for operation. Bulk hardening and induction surface hardening as two different post-deposition heat treatments are applied on TiN-coated 42CrMo4 (AISI 4140) substrates. The results show great advantages of induction surface hardening because only low distortion appear...

  12. Erstellung einer Checkliste zur Beurteilung des Arbeitsplatzes eines Physiotherapeuten nach ergonomischen Gesichtspunkten

    OpenAIRE

    Gauermann, Christoph

    2013-01-01

    Einleitung: Arbeitsbedingte Erkrankungen des Muskel-Skelett-Systems sind unter Physiotherapeuten sehr häufig. Die präventive Forschung hat diese Berufsgruppe bisher kaum untersucht. In diesem Zusammenhang stellt die Veränderung des Arbeitsumfeldes einen vielversprechenden Ansatz für die Verhinderung arbeitsbedingter Erkrankungen dar. Das Ziel dieser Arbeit ist die Erstellung einer Checkliste zur Bewertung des Arbeitsplatzes eines Physiotherapeuten zu erstellen. Material und Methoden: ...

  13. Das Konzept "Neue Soziale Bewegungen" nach Alain Touraine und die Grenzen seiner Anwendbarkeit in Guatemala

    OpenAIRE

    Kalny, Eva

    2012-01-01

    "Sowohl indigene Bewegungen als auch soziale Bewegungen gegen Großprojekte wie Staudämme, Minen und den Anbau von Palmöl und Zuckerrohr für die Gewinnung von Agrarsprit sind im Nachkriegsguatemala sehr aktiv. Dabei ist im letzten Jahrzehnt eine Verschiebung von identitären Forderungen hin zur vermehrten Verteidigung natürlicher Ressourcen beobachtbar. Der verstärkte Kampf um die Erhaltung des Lebensraums, der in ganz Lateinamerika zu beobachten ist, greift in Guatemala auf indigene Konzepte z...

  14. Kompromiss für UN-Weltgipfel zur Informationgesellschaft nach Verhandlungsmarathon gefunden

    CERN Multimedia

    Kleinwächter, Wolfgang

    2003-01-01

    At 14.43 local time, after a full week of discussions and several interruptions, it was achieved. After two years of negociations before the first president steps to the rednerpult of the world summit

  15. The international regime for nuclear safety after Fukushima; Das internationale System nuklearer Sicherheit nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Raetzke, Christian [CONLAR Consulting on Nuclear Law and Regulation, Leipzig (Germany)

    2014-05-15

    The Chernobyl catastrophe in 1986 lead to a new foundation of the international regime for nuclear safety: the 1994 Convention on Nuclear Safety introduced for the first time obligations on adhering states to adopt certain principles to achieve a high level of safety. The Convention, however, does not contain detailed standards, nor does it install a 'hard' mechanism for control and enforcement. While the system has undoubtedly lead to improvements in nuclear safety worldwide, it was not able to detect and remedy the deficiencies in the Japanese system. Ideas voiced immediately after the Fukushima accident to take a further decisive step towards a more stringent international system seemed not to be met with enthusiasm. The general tendency is to use the existing instruments and mechanisms in a more effective manner. However, very recently (in April 2014) the member states of the Convention on Nuclear Safety decided to stage a diplomatic conference with the aim to amend the Convention and to insert safety objectives. Time will eventually show whether this is a first, but decisive step towards the idea of an international system of mandatory and enforceable nuclear safety standards. (orig.)

  16. Biotechnologische Nutzung der Schwerelosigkeit für medizinische Forschung - Analyse humaner Zellen nach Schwerelosigkeit

    DEFF Research Database (Denmark)

    Grimm, Daniela Gabriele; Bauer, Johann; Hemmersbach, Ruth

    2013-01-01

    For periods of time ranging from 22 seconds in parabolic flights and up to two weeks on sattilites, human cells were exposed to real or simulated weightlessness on a Random Positioning Machine and a 2D clinostat and analysed afterwards. By this approach we can increase our knowledge regarding...... health problems of space travellers and in parallel we get new information concerning several diseases of humans on Earth. Surprisingly, we also observed that single cells exposed to simulated microgravity assemble to three-dimensional aggregates resembling the tissues from which these cells...

  17. Heidegger und der Nationalsozialismus oder die Frage nach dem philosophischen Empirismus

    NARCIS (Netherlands)

    Blok, V.

    2010-01-01

    This contribution discusses the philosophical meaning of Martin Heidegger’s Rectoral address. Firstly, Heidegger’s philosophical basic experience (Grunderfahrung) is sketched as providing the background of his Rectoral address: the being-historical concept of beginning (Anfang). Next, the

  18. Sekundärinsolvenzverfahren nach der Europäischen Insolvenzverordnung

    DEFF Research Database (Denmark)

    Ringe, Georg

    2013-01-01

    an economic activity with a “minimum of organisation and certain stability”. This decision stands in conformity with the leading academic comment and other case-law. Nevertheless, the decision is a good opportunity to stress the importance of secondary proceedings and their function to protect local creditors....... This is particularly true where the secondary proceedings are initiated (as here) in the context of a cross-border transfer of the “centre of main interests” (COMI) of the debtor. The ongoing review of the European Insolvency Regulation should respond to this problem in one of the regulatory options provided....

  19. Vertically transmitted HPV-dependent squamous cell carcinoma of the external auditory canal. Case report of a child

    Energy Technology Data Exchange (ETDEWEB)

    Snietura, Miroslaw; Pakulo, Slawomir; Kopec, Agnieszka; Piglowski, Wojciech; Stanek-Widera, Agata [Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Tumor Pathology Department, Gliwice (Poland); Chelmecka-Wiktorczyk, Liliana [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Drabik, Grazyna [University Children' s Hospital of Cracow, Pathology Department, Cracow (Poland); Kosowski, Bogdan [NZOZ Prosmed, Cracow (Poland); Wyrobek, Lukasz [University Children' s Hospital of Cracow, Department of Radiology, Cracow (Poland); Balwierz, Walentyna [University Children' s Hospital of Cracow, Department of Oncology and Hematology, Cracow (Poland); Jagiellonian University in Cracow, Clinic of Oncology and Hematology, Polish-American Pediatric Institute, Cracow (Poland)

    2017-02-15

    -negative Tumoren des Kopf- und Halsbereichs treten vor allem bei Erwachsenen auf und sind bei Kindern eine Seltenheit. Daher begruendete die Diagnose eines Plattenepithelkarzinoms des aeusseren Gehoergangs bei einem 2-jaehrigen Kind die Notwendigkeit, die Krankheit eingehend zu untersuchen und zu beschreiben. Wir berichten ueber ein 2-jaehriges Maedchen, das von einer HPV-positiven Mutter geboren wurde, bei der waehrend der Schwangerschaft Gebaermutterhalskrebs diagnostiziert worden war. Die Geburt erfolgte per Kaiserschnitt. Die Mutter erlag 7 Monate nach der Geburt ihrer Krebserkrankung. Das Kind wurde nach der Diagnose eines lokal fortgeschrittenen HPV-positiven Plattenepithelkarzinoms des aeusseren Gehoergangs operativ und ergaenzend mit Radio- und Chemotherapie behandelt. Erreicht wurde eine komplette Remission fuer mindestens 325 Wochen nach Beginn der Behandlung, sodass mehr als 6 Jahre keine Krankheitssymptome aufgetreten sind. Dies ist die erste Fallbeschreibung eines stark fortgeschrittenen HR-HPV-positiven HNSCC des aeusseren Gehoergangs bei einem 2-jaehrigen Kind, bei dem nach Anwendung einer nichtradikalen chirurgischen Behandlung sowie einer Chemo- und Strahlentherapie eine spektakulaere Reaktion und ein aktuell 6-jaehriges krankheitsfreies Ueberleben erreicht wurden. Dieser Fall bestaetigt die Beobachtungen, nach denen HNSCC-Tumoren im Zusammenhang mit HR-HPV guenstig auf die Behandlung ansprechen - trotz des klinisch fortgeschrittenen Tumorstadiums und des jungen Patientenalters. (orig.)

  20. Glycolytic pathway (GP), kreb's cycle (KC), and hexose monophosphate shunt (HMS) activity in myocardial subcellular fractions exposed to cannabinoids

    Energy Technology Data Exchange (ETDEWEB)

    Watson, A.T.; Manno, B.R.; King, J.W.; Fowler, M.R.; Dempsey, C.A.; Manno, J.E.

    1986-03-05

    Delta-9-tetrahydrocannabinol (..delta../sup 9/-THC), the primary psychoactive component of marihuana, and its active metabolite 11-hydroxy-..delta../sup 9/-tetrahydrocannabinol (11-OH-..delta../sup 9/-THC) have been reported to produce a direct cardiac depressant effect. Studies in isolated perfused rat hearts have indicated a decreased force of contraction (inotropic response) when ..delta../sup 9/-THC or 11-OH-..delta../sup 9/-THC was administered in microgram amounts. The mechanism and site of action have not been explained or correlated with associated metabolic pathways. The purpose of this study was to investigate the effects of cannabinoids on major myocardial energy producing pathways, GP and KC, and a non-energy producing pathway, HMS. Cardiac ventricular tissue from male Sprague-Dawley rats (250-300 g) was excised and homogenized for subcellular fractionation. KC, GP and HMS activity was assayed in the appropriate fractions by measuring /sup 14/CO/sub 2/ generation from /sup 14/C-2-pyruvate, /sup 14/C-6-glucose and /sup 14/C-1-glucose respectively. Duplicate assays (n=8) were performed on tissue exposed to saline (control), empty liposomes (vehicle) and four doses each of ..delta../sup 9/-THC and 11-OH-..delta../sup 9/-THC. Changes in metabolic activity and decreases in cardiac contractile performance may be associated.

  1. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis.

    Science.gov (United States)

    Cline, Gary W; Pongratz, Rebecca L; Zhao, Xiaojian; Papas, Klearchos K

    2011-11-11

    Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with (31)P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by (13)C NMR isotopomer analysis of the fate of [U-(13)C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was found to be congruous with the correlation in KRB. Together, these results suggest that signaling mechanisms associated with both TCA cycle flux and with anaplerotic flux, but not ATP production, may be responsible for the enhanced rates of insulin secretion in more complex, and physiologically-relevant media. Copyright © 2011 Elsevier Inc. All rights reserved.

  2. Rates of insulin secretion in INS-1 cells are enhanced by coupling to anaplerosis and Kreb's cycle flux independent of ATP synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Cline, Gary W., E-mail: gary.cline@yale.edu [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States); Pongratz, Rebecca L.; Zhao, Xiaojian [The Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 (United States); Papas, Klearchos K. [Department of Surgery, University of Minnesota-Twin Cities, Minneapolis, MN 55455 (United States)

    2011-11-11

    Highlights: Black-Right-Pointing-Pointer We studied media effects on mechanisms of insulin secretion of INS-1 cells. Black-Right-Pointing-Pointer Insulin secretion was higher in DMEM than KRB despite identical ATP synthesis rates. Black-Right-Pointing-Pointer Insulin secretion rates correlated with rates of anaplerosis and TCA cycle. Black-Right-Pointing-Pointer Mitochondria metabolism and substrate cycles augment secretion signal of ATP. -- Abstract: Mechanistic models of glucose stimulated insulin secretion (GSIS) established in minimal media in vitro, may not accurately describe the complexity of coupling metabolism with insulin secretion that occurs in vivo. As a first approximation, we have evaluated metabolic pathways in a typical growth media, DMEM as a surrogate in vivo medium, for comparison to metabolic fluxes observed under the typical experimental conditions using the simple salt-buffer of KRB. Changes in metabolism in response to glucose and amino acids and coupling to insulin secretion were measured in INS-1 832/13 cells. Media effects on mitochondrial function and the coupling efficiency of oxidative phosphorylation were determined by fluorometrically measured oxygen consumption rates (OCRs) combined with {sup 31}P NMR measured rates of ATP synthesis. Substrate preferences and pathways into the TCA cycle, and the synthesis of mitochondrial 2nd messengers by anaplerosis were determined by {sup 13}C NMR isotopomer analysis of the fate of [U-{sup 13}C] glucose metabolism. Despite similar incremental increases in insulin secretion, the changes of OCR in response to increasing glucose from 2.5 to 15 mM were blunted in DMEM relative to KRB. Basal and stimulated rates of insulin secretion rates were consistently higher in DMEM, while ATP synthesis rates were identical in both DMEM and KRB, suggesting greater mitochondrial uncoupling in DMEM. The relative rates of anaplerosis, and hence synthesis and export of 2nd messengers from the mitochondria were found to be similar in DMEM to those in KRB. And, the correlation of total PC flux with insulin secretion rates in DMEM was found to be congruous with the correlation in KRB. Together, these results suggest that signaling mechanisms associated with both TCA cycle flux and with anaplerotic flux, but not ATP production, may be responsible for the enhanced rates of insulin secretion in more complex, and physiologically-relevant media.

  3. Certified quality management according to DIN ISO 9001 in a radiology department at a university hospital. Measurable changes in academic quality indicators?; Qualitaetsmanagement nach DIN ISO 9001 an einer radiologischen Universitaetsklinik. Messbare Veraenderungen der universitaeren Kennzahlen nach der Zertifizierung?

    Energy Technology Data Exchange (ETDEWEB)

    Lorenzen, Joern; Habermann, C.; Weber, C.; Adam, G.; Koops, A. [Diagnostikzentrum, Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie, Universitaetsklinikum Hamburg-Eppendorf (Germany); Utler, C. [Geschaeftsbereich Qualitaetsmanagement, Universitaetsklinikum Hamburg-Eppendorf (Germany); Grzyska, U. [Diagnostikzentrum, Klinik und Poliklinik fuer Neuroradiologische Diagnostik und Intervention, Universitaetsklinikum Hamburg-Eppendorf (Germany)

    2009-10-15

    Purpose: to evaluate the changes in academic quality indicators after implementation of a quality management system according to DIN ISO 9001:2000. Materials and methods: after implementation and certification of a quality management system, the actual state based on quality indicators from the fields of student teaching, research, continuing education and the satisfaction of referring physician was determined. After implementation of an action plan for the individual areas, the temporal changes in the ratios were documented in the follow-up. Results: the evaluation of teaching performance obtained by questionnaire among the students of the radiology course showed a steady increase in satisfaction (mean value 2003: 2.7; 2007: 3.9). In the field of research an increase in scientific output was achieved based on the number of an internal publication score (2002: 99 points; 2006: 509). Repeated opinion surveys among our referring physicians found improvements in indicators for the appointment of investigations, consulting service and waiting times for the investigation, while the waiting times for internal transport service did not improve. Exemplary measurements of the success of the advanced training of the staff demonstrated the need for continuing education for quality improvement. Conclusion: the evaluation of quality indicators showed over time a measurable positive impact on processes of a radiological Univ. Hospital after implementation of a QM system according to DIN ISO 9001:2000. (orig.)

  4. CT after renal extracorporeal shock waves lithotripsy (ESWL). Pt. 2. Correlation with histopathologic findings three weeks after animal experiment. Computertomographie nach extrakorporaler Stosswellen-Lithotripsie (ESWL) der Nieren. T. 2. Korrelation mit histopathologischen Befunden nach 3 Wochen im Tierexperiment

    Energy Technology Data Exchange (ETDEWEB)

    Schaub, T.; Kunisch, M.; Stadtbaeumer, M.; Schild, H.; Thelen, M. (Mainz Univ. (Germany, F.R.). Inst. fuer Klinische Strahlenkunde); Stoerkel, S. (Mainz Univ. (Germany, F.R.). Pathologisches Inst.); El-Damanhoury, H. (Mainz Univ. (Germany, F.R.). Urologische Klinik und Poliklinik); Hennes, H.J. (Mainz Univ. (Germany, F.R.). Anaesthesiologische Klinik)

    1991-05-01

    In a pig model, 13 kidneys were treated with a second generation lithotripter and examined by CT immediately and three weeks after ESWL. 9 (69%) acute traumatic lesions were seen in CT without, and 10 (77%) in CT with contrast in the 13 treated kidneys. After 3 weeks only 1 residual lesion persisted in CT contrast studies. On the histopathologic specimens residuals of bleeding were found in 3 (23%) of the 13 kidneys treated, which could not be seen in CT studies. CT is accurate in monitoring acute traumatic renal lesions after ESWL, but appears less reliable in chronic ones. Three weeks after ESWL traumatic renal lesions show marked regression. (orig.).

  5. The premature possession briefing according to paragraph 44b EnWG. The legal situation according to the infrastructure planning acceleration law; Die vorzeitige Besitzeinweisung nach paragraph 44b EnWG. Die Rechtslage nach dem Infrastrukturplanungs-Beschleunigungsgesetz

    Energy Technology Data Exchange (ETDEWEB)

    Riedel, D. [Kanzlei Dombert Rechtsanwaelte, Potsdam (Germany)

    2008-03-15

    On 17th December 2006, the infrastructure planning acceleration law comes into force. This law plans to tighten the realization of urgent infrastructure projects. Above all, this concerns to changes, which follow from this law for the right of the expropriation. Under this aspect, the author of the contribution under consideration reports on the objective of the infrastructure planning acceleration law as well as on the conditions and factual characteristics of the possession briefing. The straight premature possession briefing represents a good starting point to clearly shorten the time of the filing of an application in the planning procedure up to the actual commencement of construction. The legislative fundament for this is existent.

  6. Untersuchungen der Narbenqualität nach unterschiedlichen Verfahren des Wundverschlusses und der Wundbehandlung durch autologe Hauttransplantation

    OpenAIRE

    Zeplin, Philip Helge

    2005-01-01

    Die qualitative und quantitative Narbenqualitätsmessungen im Verlauf der Wundheilung ist von großer Bedeutung, da durch sie Einflussgrößen, die mit hoher Wahrscheinlichkeit zu pathologischen Narbenformationen führen, frühzeitig erkannt werden könnten und Rückschlüsse auf die jeweils angewandten Techniken und Materialien zulassen würden. Dass für die Analyse der Heilung von Schnitt- und Defektwunden objektive Messungen unabdingbar sind, sollte am Beispiel des Göttinger Miniaturschweins gezeigt...

  7. Automation of an energy-autarkic manufacturing plant following IEC 61499; Automatisierung einer energieautarken Fertigungsanlage nach IEC 61499

    Energy Technology Data Exchange (ETDEWEB)

    Gerber, Christian; Hirsch, Martin; Hanisch, Hans-Michael [Halle-Wittenberg Univ., Halle (Saale) (Germany). Lehrstuhl Automatisierungstechnik

    2009-07-01

    The requirements for future manufacturing plants are, beyond others, seamless reconfiguration, autonomy as far as possible as well as easy employment and maintenance for the end user. Within the EnAS project (Energy-Autarkic Actuators and Sensors), the group of the Automation Technology Lab in Halle has challenged the fulfillment of those requirements. Therefore, IEC 61499 compliant distributed controllers have been developed for the demonstrator-plant under particular consideration of reconfigurability. These controllers have been integrated into the process sequences of the demonstrator and afterwards several reconfiguration scenarios have been designed. The building of a Human-Machine-Interface for visualization and reconfiguration of the plant was an essential issue as well. The result is a highly flexible, easily reconfigurable system, which can be regarded as a prototype for automated manufacturing plants of a new generation. (orig.)

  8. Erzwingt die Quantenmechanik eine drastische Änderung unseres Weltbilds? Gedanken und Experimente nach Einstein, Podolsky und Rosen

    Science.gov (United States)

    Frodl, Peter

    Von den Anfängen der Quantenmechanik bis heute gibt es Versuche, sie als statistische Theorie über Ensembles individueller klassischer Systeme zu interpretieren. Die Bedingungen, unter denen Theorien verborgener Parameter zu deterministischen Beschreibungen dieser individuellen Systeme als klassisch angesehen werden können, wurden von Einstein, Podolsky und Rosen 1935 formuliert: 1. Physikalische Systeme sind im Prinzip separierbar. 2. Zu jeder physikalischen Größe, deren Wert man ohne Störung des betrachteten Systems mit Sicherheit voraussagen kann, existiert ein ihr entsprechendes Element der physikalischen Realität.Zusammen sind sie, wie Bell 1964 gezeigt hat, prinzipiell unverträglich mit der Quantenmechanik und unhaltbar angesichts neuerer Experimente. Diese erweisen einmal mehr die Quantenmechanik als richtige Theorie. Um ihre Ergebnisse zu verstehen, müssen wir entweder die in der klassischen Physik als selbstverständlich angesehene Annahme der Separierbarkeit physikalischer Systeme aufgeben oder unseren Begriff der physikalischen Realität revidieren. Eine Untersuchung des Begriffs der Separabilität und einige Überlegungen zum Problem der Messung von Observablen zeigen, daß eine Änderung des Begriffs der physikalischen Realität unumgänglich ist. Der revidierte Realitätsbegriff sollte mit klassischer Physik und Quantenmechanik verträglich sein, um ein einheitliches Weltbild zu ermöglichen.Translated AbstractDo Quantum Mechanics Force us to Drastically Change our View of the World? Thoughts and Experiments after Einstein, Podolsky and RosenSince the advent of quantum mechanics there have been attempts of its interpretation in terms of statistical theory concerning individual classical systems. The very conditions necessary to consider hidden variable theories describing these individual systems as classical had been pointed out by Einstein, Podolsky and Rosen in 1935: 1. Physical systems are in principle separable. 2. If it is possible to predict with certainty the value of a physical quantity without disturbing the system under consideration, then there exists an element of physical reality corresponding to this physical quantity.Together they are, as was shown by Bell in 1964, incompatible in principle with quantum mechanics and no more tenable in view of recent experiments. These experiments once more corroborate quantum theory. In order to understand their results we are forced either to drop the assumption of separability of physical systems (taken for self-evident in classical physics) or to change our concept of physical reality. After investigating the notion of separability and connecting the EPR-correlations to the measurement problem we, conclude that a change of the concept of physical reality is indispensable. The revised concept should be compatible with both classical and quantum physics in order to allow a uniform view of the physical world.

  9. Post Fukushima change of energy policy. German special way or worldwide example?; Energiewende nach Fukushima. Deutscher Sonderweg oder weltweites Vorbild?

    Energy Technology Data Exchange (ETDEWEB)

    Hennicke, Peter; Welfens, Paul J.J.

    2012-07-01

    Based on a critical evaluation of the nuclear power discussion the authors show a reasonable way for nuclear phase-out or change to alternative energy sources. Germany has a historically unique key role to show that a climate protecting energy policy without nuclear power can evolve economic and social advantages, in case the right measures are selected and realized. The Fukushima accidents could trigger a paradigm change for the power industry with a worldwide effect toward industrial ecology and democracy. The worldwide underinsurance of nuclear power plants is a trick to reduce the nuclear power cost. Without subsidization of nuclear power there is no need for subsidization of renewable energy sources.

  10. Umgang mit Antithrombotika bei Operationen an der Haut vor und nach Publikation der entsprechenden S3-Leitlinie.

    Science.gov (United States)

    Gaskins, Matthew; Dittmann, Martin; Eisert, Lisa; Werner, Ricardo Niklas; Dressler, Corinna; Löser, Christoph; Nast, Alexander

    2018-03-01

    Laut einer Befragung im Jahre 2012 war der Umgang mit Antithrombotika bei dermatochirurgischen Eingriffen in Deutschland sehr heterogen. 2014 wurde erstmals eine evidenzbasierte Leitlinie zu diesem Thema veröffentlicht. Es wurde eine anonyme Befragung derselben Stichprobe zum Umgang mit Antithrombotika sowie zu Kenntnissen der Leitlinie durchgeführt. Die Ergebnisse wurden als relative Häufigkeiten berichtet und denen aus 2012 gegenübergestellt. 208 Antwortbögen wurden ausgewertet (Rücklaufquote: 36,6 %). Die große Mehrheit der Dermatologen erklärte, kleinere Eingriffe unter Fortführung der Therapie mit Phenprocoumon, niedrig dosierter Acetylsalicylsäure (≤ 100 mg) und Clopidogrel sowie mit direkten oralen Antikoagulanzien durchzuführen. Bei größeren Eingriffen war der Umgang hingegen weiterhin heterogen, insbesondere unter niedergelassenen Dermatologen. Der Anteil der Dermatologen, die Phenprocoumon, Acetylsalicylsäure und Clopidogrel leitlinienkonform verwendeten, hat sich insgesamt vergrößert. Führten 2012 beispielsweise 53,8 % der Klinikärzte bzw. 36,3 % der niedergelassenen Dermatologen eine große Exzision unter Fortführung der Therapie mit niedrig dosierter Acetylsalicylsäure durch, taten dies 2017 90,2 % bzw. 57,8 % (Phenprocoumon: 33,8 % bzw. 11,9 % auf 63,9 % bzw. 29,9 %; Clopidogrel: 36,9 % bzw. 23,2 % auf 63,9 % bzw. 30,6 %). Unter den Klinikärzten war ein hoher Anteil mit der Leitlinie vertraut und fand diese hilfreich. Eine Zunahme des leitlinienkonformen Verhaltens war bei allen Eingriffen zu verzeichnen. Bei größeren Eingriffen zeigte sich trotz deutlicher Verbesserung die Notwendigkeit verstärkter Anstrengungen zur Leitlinienumsetzung bzw. zur Identifizierung von Implementierungsbarrieren. © 2018 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.

  11. Die Reichweite der Haftungsprivilegien nach dem SGB VII außerhalb des klassischen Arbeitsunfalls / Tobias Matz ; Claudia Baumann

    Index Scriptorium Estoniae

    Matz, Tobias

    2016-01-01

    Ettevõtte ja kollektiivi vastutusest sotsiaalseadustiku § 104 jj tähenduses ebatraditsiooniliste tööõnnetuste korral (nt koolides õpilaste/õpetajate vigastused; praktikandid kutseõppes; loomade tekitatud vigastused jms)

  12. 20 years after Chernobyl. A radiation protection perspective; 20 Jahre nach Tschernobyl. Eine Bilanz aus Sicht des Strahlenschutzes

    Energy Technology Data Exchange (ETDEWEB)

    Baldauf, D.; Gumprecht, D.; Heller, H. (comps.)

    2006-07-01

    Together with the Bhopal and Seveso accident, the Chernobyl accident was the biggest distaster in the application of technologies. There was much suffering involved which should not be forgotten. On the other hand, a scientific organization like the Radiation Protection Commission (SSK) must take care to distinguish between injuries caused by radiation and others not caused by radiation. While this may appear cold-hearted, there is a need for a detailed scientific analysis in order to gain information for better radiation protection in the future. In this volume, SSK therefore attempts to answer questions concerning the effects of the reactor accident in the Chernobyl region and also in Germany. On the basis of the contribution, SSK drew up a comprehensive statement which was passed in the SSK meeting of 1 March 2006. (orig.)

  13. IT-Compliance nach COBIT: Gegenüberstellung zwischen COBIT 4.0 und COBIT 5

    OpenAIRE

    Klotz, Michael

    2014-01-01

    Mit der aktuellen fünften Version (COBIT 5) wurden grundlegende Erweiterungen und Änderungen des COBIT-Frameworks vorgenommen. Inwieweit sich dies auf das IT-Compliance-Verständnis und das Management von IT-Compliance ausgewirkt hat, wird in diesem Arbeitspapier untersucht. Hierzu werden die vierte und die fünfte Version von COBIT auf ihre compliance-relevanten Aussagen hin untersucht und vergleichend gegenübergestellt. Im Ergebnis weist COBIT 4.0 in seiner Struktur zahlreiche Inkonsistenzen ...

  14. Basics about online boiler cleaning according to the Schwandorf principle; Grundlagen zur Online-Kesselreinigung nach dem Schwandorfer Prinzip

    Energy Technology Data Exchange (ETDEWEB)

    Krueger, Joerg [VWT Ing.-Buero, Schwandorf (Germany); Krueger, Sascha [IBK-Verfahrenstechnik, Bad Berka (Germany)

    2013-10-01

    In the Schwandorf waste-to-energy (WtE) plant more than ten years ago a wet online boiler cleaning system was developed which has the capability to clean the radiation passes of (WtE-, biomass- and refuse derived fuel (RDF)) boilers without damaging the boiler. During the development it was recognised that the method of atomising the washing agent (water) is highly influencing the effectiveness of cleaning by securing parts of the boiler (membrane walls). (orig.)

  15. Pneumonitis following infradiaphragmatic irradiation in Hodgkin's disease. Pneumonitis nach infradiaphragmaler Bestrahlung bei Morbus Hodgkin

    Energy Technology Data Exchange (ETDEWEB)

    Zierhut, D.; Flentje, M. (Radiologische Klinik, Heidelberg Univ. (Germany)); Kalle, A. von (Medizinische Poliklinik, Heidelberg Univ. (Germany)); Moeller, P. (Pathologisches Inst., Heidelberg Univ. (Germany))

    1992-12-01

    A case is reported on radiation pneumonitis in the left costodiaphragmatic sinus 6 weeks following combined chemo- and radiotherapy of Hodgkin's disease. Thoracotomy was performed in order to exclude a pulmonal relapse of Hodgkin's disease. Thereby the diagnosis of radiation pneumonitis was histologically proven. The development of pneumonitis after irradiation of the spleen may occur and has to be considered in the differential diagnosis of pulmonal affections. (orig.).

  16. The gas grid control room, provider of external and internal services; Die Gasnetzleitwarte. Ein Dienstleister nach innen und aussen?

    Energy Technology Data Exchange (ETDEWEB)

    Brychcy, Andreas [NBB Netzgesellschaft Berlin-Brandenburg mbH und Co. KG, Berlin (Germany)

    2010-05-15

    The main task of the control room is the maintenance and extension of competence in a dynamically developing market environment. Grid control rooms must be able to react flexibly to changes in the market and accompany them in an active manner. (orig.)

  17. Office building with an underground storage system. Operational experiences after one year; Buerogebaeude mit Erdspeicher. Betriebserfahrungen nach einem Jahr

    Energy Technology Data Exchange (ETDEWEB)

    Braun, Dorothee; Wehrli, Stefan [Basler und Hofmann AG, Zuerich (Switzerland)

    2011-07-01

    Self-sufficient heating and cooling - that was the principle of Basler paragraph Hofmann AG (Zuerich, Switzerland) and Stuecheli Architects (Zuerich, Switzerland) in the planning and constructing of a new office building in the Canton of Zuerich. For the first time an underground storage system was implemented in a commercial building. This underground storage refuels the solar energy in summer and supplies heating energy in winter. The office building was settled in in September, 2010. The pioneering project now delivers first empirical values with the underground storage system. These empirical values show: The concept comes up, but needs time.

  18. The EU regulations after the events in Japan; Die Regelungen der EU nach den Ereignissen in Japan

    Energy Technology Data Exchange (ETDEWEB)

    Giessing, Reinhart

    2011-07-01

    On March 27th 2001 after the nuclear accident in Fukushima an EU regulation concerning the import of food and feeding stuff with origin in Japan came into effect. The regulations included radiation limits that had not to be exceeded. The Japanese authorities were supposed to declare the control of the exported food and feeding stuff. The control measurements had to be performed with respect to I-131, Cs-134 and Cs-137. The validity was defined by June 30th, 2011.

  19. Nach der Genderforschung ist vor der Genderforschung“ – oder? Gender Studies: There’s Always More—Right?

    Directory of Open Access Journals (Sweden)

    Barbara Scholand

    2008-11-01

    Full Text Available Der Frage, ob die Kategorie ‚Gender‘ ausgedient hat oder weiter ertragreich genutzt werden kann, stellen sich die Autorinnen und Autoren des Bandes in einem von Erziehungswissenschaftler/-innen veranstalteten „Interdisziplinären Gespräch“. Eine Bestandsaufnahme der feministischen Theoriebildung wird vorgenommen und – durchaus vorhandene – neue Perspektiven werden aufgezeigt und diskutiert. Ein spezifisch erziehungswissenschaftliches Profil im Kontrast zu den Beiträgen aus Soziologie, Philosophie, Politikwissenschaft und Geschichte wird allerdings nicht deutlich.The authors of this volume question whether the category of ‘gender’ has become worn out or whether it can still be useful in ‘interdisciplinary conversations’ between pedagogues. They carry out an assessment of the state of feminist theoretical development and they point to and discuss new perspectives, all of which exist today. However, the book does not clarify its specifically pedagogical profile as compared to the contributions from sociology, philosophy, political science, and history.

  20. Magnetic resonance imaging findings after shoulder surgery: What the radiologist needs to know; Besonderheiten der Magnetresonanztomographie nach operativer Schulterintervention

    Energy Technology Data Exchange (ETDEWEB)

    Fahlenkamp, U.L.; Hermann, K.G.A. [Universitaetsklinikum Charite - Campus Mitte, Institut fuer Radiologie, Berlin (Germany); Gerhardt, C. [Universitaetsklinikum Charite - Campus Mitte, Centrum fuer muskuloskeletale Chirurgie, Berlin (Germany)

    2017-11-15

    Even primary diagnostic evaluation of the shoulder is a challenge for radiologists. Many imaging findings that definitely indicate abnormal findings in the untreated shoulder should be evaluated carefully in postoperative patients. Artifacts caused by implants or metal abrasion pose considerable problems in postoperative magnetic resonance imaging (MRI). Classic approaches to minimizing artifacts caused by foreign bodies include using turbo spin echo sequences, increasing bandwidth, and reducing voxel size. In recent years, several vendors have developed dedicated pulse sequences for reducing metal artifacts. Different postoperative imaging findings will be encountered, depending on the kind of surgery done. This review article describes typical postoperative MRI findings, focusing on subacromial decompression, reconstruction of the rotator cuff, labrum procedures, and biceps tenodesis. (orig.) [German] Das Schultergelenk stellt fuer jeden Radiologen bereits in der primaeren Diagnostik eine Herausforderung dar. Viele Bildbefunde, welche bei einer nicht therapierten Schulter als eindeutig pathologisch zu bewerten sind, muessen im postoperativen Setting als kritisch bewertet werden. Artefakte durch Implantate oder Metallabrieb stellen eine grosse Huerde der postoperativen Magnetresonanztomographie dar. Klassische Methoden, um Artefakte durch Fremdmaterial so gering wie moeglich zu halten, bestehen in der Anwendung von Turbo-Spin-Echo-Sequenzen sowie in der Erhoehung der Bandbreite oder der Reduktion der Voxelgroesse. Mittlerweile haben einige Anbieter jedoch spezielle Sequenzen zur Reduktion von Metallartefakten entwickelt. In Abhaengigkeit von der erfolgten Schulteroperation muessen verschiedene Bildbefunde beruecksichtigt werden. Dieser Uebersichtsartikel geht insbesondere auf die subakromiale Dekompression, die Rekonstruktion der Rotatorenmanschette, Operationen am Labrum sowie Bizepstenodesen ein und beschreibt typische postoperative Befunde. (orig.)

  1. Price abuse monitoring under paragraph 29 of the Law Against Restraints on Competition; Die Preismissbrauchskontrolle nach paragraph 29 GWB

    Energy Technology Data Exchange (ETDEWEB)

    Koleva, Raliza

    2013-08-01

    Written against the backdrop of criticism levelled at paragraph 29 of the Law Against Restraints on Competition (GWB) the present study undertakes a critical discussion of this legal norm along with questions and points of criticism that have been raised in its context in the literature and case law. It first addresses the central question as to whether paragraph 29 GWB conforms to the stipulations of European law and the German constitution. It then expounds the system behind paragraph 29 GWB, making a detailed examination of the individual elements of the offences covered by the regulation while giving thorough consideration to existing case law on instruments of price abuse monitoring that have been used to date under cartel law. A further focus of the present study is on the question as to what circumstances a supply company under suspicion of price abuse may claim in attempting to justify significant differences that have been found to exist between its own prices and those of a comparable company. This aspect is of great practical relevance in lawsuits concerning price abuse under cartel law, since the option of demonstrating justification is the most important line of approach for supply companies under suspicion of price abuse in attempting to fend off such allegations. Based on an analysis of past practice of the German Federal Cartel Office and the antitrust courts the author undertakes to determine a scale for assessing the costs which the responding supply company can claim in its defence. Finally she endeavours to methodologically capture the price limit concept, making proposals for its practical application with due consideration to the findings that have transpired from the study.

  2. Být kaplanem v Česku: Zdroje nejistoty a nacházení opory

    Czech Academy of Sciences Publication Activity Database

    Beláňová, Andrea

    2018-01-01

    Roč. 105, č. 1 (2018), s. 25-43 ISSN 0009-0794 R&D Projects: GA ČR GA17-02917S Institutional support: RVO:68378025 Keywords : Chaplaincy * uncertainty * strategies Subject RIV: AO - Sociology, Demography OBOR OECD: Sociology

  3. Peripheral neuronal damage after operation and irradiation of patients with mastocarcinoma. Periphere Nervenschaeden nach Operation und Bestrahlung wegen Mammakarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Ritz, H J

    1982-01-01

    Three hundred seventy-eight women uniformly operated on for pre-metastatic-spread mammary carcinoma and given, for the major part, uniform irradiation treatment were investigated. 34 women had suffered peripheral neuronal damage in the area of the shoulder and arm of the operated and irradiated side consisting in 20 cases in a lesion of the plexus brachialis, in 13 in an isolated lesion of the medial cutaneous nerve of the arm and in one case in an isolated lesion of the nerve to the serratus anterior muscle. The lesion of the plexus brachialis is generally supposed to have been caused by the irradiation, in individual cases a metastasis or tumor infiltration into the plexus or surgical damage is also considered. The isolated lesions of individual arm nerves are attributed to surgical damage or to tensile and pressure-type stress caused by inappropriate position during surgery. Moreover there was a concomitant lesion of the medial cutaneous nerve of the arm in 4, and of the nerve to the serratus anterior muscle in 8 cases. In these cases radiation-induced damage in the plexus area cannot be excluded. In 7 cases slight atrophy noted at the upper edge of the trapezius muscle led to suspect direct radiation damage of the muscle, the actual frequency of which could, however, not safely be determined because of the common subcutaneous induration at the shoulder contour.

  4. Peripheral neuronal damage after operation and irradiation of patients with mastocarcinoma. Periphere Nervenschaeden nach Operation und Bestrahlung wegen Mammakarzinom

    Energy Technology Data Exchange (ETDEWEB)

    Ritz, H J

    1982-01-01

    378 women uniformly operated on for pre-metastatic-spread mammary carcinoma and given, for the major part, uniform irradiation treatment were investigated. 34 women had suffered peripheral neuronal damage in the area of the shoulder and arm of the operated and irradiated side consisting in 20 cases in a lesion of the plexus brachialis, in 13 in an isolated lesion of the medial cutaneous nerve of the arm and in one case in an isolated lesion of the nerve to the serratus anterior muscle. The lesion of the plexus brachialis is generally supposed to have been caused by the irradiation, in individual cases a metastasis or tumor infiltration into the plexus or surgical damage is also considered. The isolated lesions of individual arm nerves are attributed to surgical damage or to tensile and pressure-type stress caused by inappropriate position during surgery. Moreover there was a concomitant lesion of the medial cutaneous nerve of the arm in 4, and of the nerve to the serratus anterior muscle in 8 cases. In these cases radiation-induced damage in the plexus area cannot be excluded. In 7 cases slight atrophy noted at the upper edge of the trapezius muscle led to suspect direct radiation damage of the muscle, the actual frequency of which could, however, not safely be determined because of the common subcutaneous induration at the shoulder contour.

  5. NAChR α4β2 subtype and their relation with nicotine addiction, cognition, depression and hyperactivity disorder.

    Science.gov (United States)

    Laikowski, Manuela M; Reisdorfer, Favero; Moura, Sidnei

    2018-04-09

    Neuronal α4β2 nAChRs are receptors involved in the role of neurotransmitters regulation and release, and this ionic channel participates in biological process of memory, learning and attention. This work aims review the structure and functioning of the α4β2 nAChR emphasizing its role in the treatment of associated diseases like nicotine addiction and underlying pathologies such as cognition, depression and attention-deficit hyperactivity disorder. The authors realized extensive bibliographic research using the descriptors "Nicotine Receptor α4β2" and "cognition", "depression", "attention-deficit hyperactivity disorder", besides cross-references of the selected articles and after analysis of references in the specific literature. As results, it was found 180 relevant articles presenting the main molecules with affinity to nAChR α4β2 relating to the cited diseases. The α4β2 nAChR subtype is a remarkable therapeutic target since this is the most abundant receptor in the central nervous system. In summary, this review presents perspectives on the pharmacology and therapeutic targeting of α4β2 nAChRs for the treatment of cognition and diseases like nicotine dependence, depression and attention-deficit hyperactivity disorder. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.org.

  6. Vergleich relevanter Parameter von Multipixelsensoren für Spurdetektoren nach Bestrahlung mit hohen Proton- und Neutronflüssen

    CERN Document Server

    Bergholz, Matthias; Reif, Jürgen; Husemann, Ulrich

    2016-01-01

    The further increase of the luminosity of the Large Hadron Collider ( LHC ) at CERN requires new sensors for the tracking detector of the Compact Muon Soleniod ( CMS ) experiment. These sensors must be more radiation hard and of a finer granularity to lower the occupancy. In addition the new sensor modules must have a lower material budget and have to be self triggering. Sensor prototypes, the so called “ MPix ”-sensors, produced on different materials were investigated for their radiation hardness. These sensors were fully charac- terized before and after irradiation. Of particular interest was the comparison of different bias methods, different materials and the influence of various geometries. The degeneration rate differs for the different sensor materials. The increase of the dark current of Float-Zone-Silicon is stronger for thicker sensors and less than for Magnetic-Czochralski-Silicon sensors. Both tested bias structures are damaged by the irradiation. The poly silicon resis- tance increases after...

  7. Health consequences of Chernobyl. 25 years after the reactor catastrophy; Gesundheitliche Folgen von Tschernobyl. 25 Jahre nach der Reaktorkatastrophe

    Energy Technology Data Exchange (ETDEWEB)

    Pflugbeil, Sebastian; Schmitz-Feuerhake, Inge [Gesellschaft fuer Strahlenschutz e.V., Berlin (Germany); Paulitz, Henrik; Claussen, Angelika [Internationale Aerzte fuer die Verhuetung des Atomkrieges, Aerzte in sozialer Verantwortung e.V. (IPPNW), Berlin (Germany). Deutsche Sektion

    2011-04-15

    The report is an evaluation of studies indicating health effects as a consequence of the reactor catastrophe in Chernobyl. The most exposed population include the cleaning personnel (liquidators), the population evacuated from the 30 km zone, the populations in highly contaminated regions in Russia, Belarus and Ukraine, the European population in lass contaminated regions. The following issues are discussed: the liquidators, infant mortality, genetic and teratogenic damages, thyroid carcinoma and other thyroid diseases, carcinogenic diseases and leukemia, other diseases following the Chernobyl catastrophe.

  8. Vaterschaft nach der Scheidung – Die Perspektive der Väter Fatherhood After Divorce—The Fathers’ Perspective

    Directory of Open Access Journals (Sweden)

    Michael Matzner

    2004-11-01

    Full Text Available Während man in Deutschland die Situation von allein erziehenden Müttern gut erforscht hat, wandte man sich den von ihren Kindern getrennt lebenden Vätern nur äußerst selten zu. Dies ist mehr als erstaunlich, wenn man sich die in die Millionen gehende Zahl betroffener Väter und Kinder vor Augen führt. Allein im Jahr 2000 wurden 95.000 Ehepaare mit minderjährigen Kindern (146.000 geschieden. Bei Gerhard Amendts empirischer Studie handelt es sich um die erste deutschsprachige, als Buch erschienene wissenschaftliche Veröffentlichung zum Thema „Scheidungsväter“. Amendt beantwortet aus der Perspektive der Väter folgende Fragen: Wie sprechen Väter über ihre Scheidung und wie gehen sie mit den Scheidungsfolgen um? Wie verbringen sie die Zeit mit ihren Kindern? Warum brechen manche von ihnen den Kontakt zu den Kindern ab? Der neue Zugang zum Thema Scheidung bzw. Trennung über die Person des Vaters war längst überfällig und bringt neue Perspektiven und Erkenntnisse in die wissenschaftliche Debatte.While the situation of single mothers has been duly researched in Germany, very rarely has attention been given to fathers who live separated from their children. This is truly remarkable when one surveys the number, rising into the millions, of fathers and children affected. In the year 2000 alone, 95,000 married couples with dependant children (146,000 divorced. Gerhard Amendt’s empirical study can be seen as the first German-language, book length, scientific publication on “divorced fathers.” Arendt answers the following questions from the perspective of the fathers: How do fathers talk about divorce and how do they deal with the consequences of divorce? How do they spend time with their children? Why do some of them cut off contact to their children? This new access to the issues of divorce or separation with regard to the father was long overdue and brings new perspectives and realizations to the scientific debate.

  9. 10 years after Chernobyl, radiation exposure, health effects, safety aspects; 10 Jahre nach Tschernobyl, Strahlenbelastung, Gesundheitseffekte, Sicherheitsaspekte

    Energy Technology Data Exchange (ETDEWEB)

    Mueck, K

    1996-11-01

    This report sums up the various conferences and symposia which were prompted by the tenth anniversary of the accident in the nuclear power plant of Chernobyl. It was shown that by the accident up to now 31 casualties among the emergency and rescue personal at the site. Offsite no increased number of casualties caused by the accident was observed up to now. In the countries with the highest impact Ukraine, Belarus and Russia, however, an increased number of infant thyroid cancer is observed which is substantially higher than after the nuclear detonations over Japanese cities. Contrary to often published media reports, however, up to now no increases in leukemia or other malignant deceases were observed, neither in the population of the concerned regions nor among the liquidators. The high {sup 137}Cs activity concentration in the environment close to the power plant result in exclusion zone even today. The deposition values in Kiev, however, amount to only 30 kBq/m{sup 2}, in large areas of Ukraine they are below the average values in Austria of 22 kBq/m{sup 2}. For these areas as well as those outside the former Soviet Union the average doses were less than 1 mSv in the first year, a value which is less than one third of natural annual radiation exposure. Since the reactor accident the activity concentration has significally decreased resulting in an exposure as consequence of the reactor accident of less than 0,8 % of the exposure in the first year. In Austria the exposure in 1996 amounts to less than 0,3 % of natural radiation exposure. (author).

  10. Zusammenführen was zusammengehört – Intellektuelle und automatische Erfassung von Werken nach RDA

    Directory of Open Access Journals (Sweden)

    Barbara Pfeifer

    2016-12-01

    Full Text Available Der Beitrag will die Erschließungspraxis der Deutschen Nationalbibliothek im ersten Implementierungsschritt der RDA zur Angabe der Werkebene darstellen, Erfahrungen zur grundsätzlichen Vorgehensweise und zu Sonderregelungen vermitteln und einen Ausblick in die Zukunft bieten. Die Angabe der Werkebene als Kernelement des neuen Standards wird bei der Erschließung von Ressourcen in der Deutschen Nationalbibliothek immer berücksichtigt. Bei der intellektuellen Erschließung von Monografien wird das Element als Normdatensatz oder als textuelle Angabe im Katalogisat erfasst. Allerdings setzt die derzeitige Praxis auch auf zukünftige automatische Clusterverfahren. Der erreichte Stand zu Algorithmen und Testläufen für das Werkclustering soll ebenso aufgezeigt werden, wie die daraus resultierenden Entscheidungen und die weitere Perspektive. Von zentraler Bedeutung ist die Frage, ob und unter welchen Bedingungen auf der Basis der Werkcluster Normdatensätze für die Gemeinsame Normdatei (GND generiert werden können, um sie im deutschen Sprachraum kooperativ zu nutzen und sie in der Linked-Data-Cloud zu vernetzen.   This article explains how works are catalogued at the Deutsche Nationalbibliothek (German National Library in the first implementation step of RDA. It discusses experiences with the general approach as well as some special rules and points out future prospects. When cataloguing resources at the Deutsche Nationalbibliothek, the work entity is always included as the work elements are core elements of the new standard. If the cataloguing is done intellectually, the work entity is described either as a link to an authority record or as a textual string within the description of the resource. However, the current practice builds also on automatic clustering of works in the future. The state of the art of automatic cluster algorithms and their evaluation and testing is described as well as the next steps for the future. An essential question is whether and under which conditions authority records for works can be generated on the basis of automatic clustering in order to use them cooperatively and to position them as crosspoints in the linked data cloud.

  11. Periprothetische Femurfrakturen nach Hüftgelenksersatz: Rationale für die intra- oder extramedulläre Behandlung

    DEFF Research Database (Denmark)

    Haag, C.; Seif El Nasr, M.; Schmal, H.

    2000-01-01

    stabilized by tension wires, 29 by extramedullary plate osteosynthesis (19 LCDCP, 10 condylar plates) and 20 with a cancellous bone graft. In 14 cases the prosthesis was replaced. The total complication rate was expected fairly high (12 cases, 26.6%), considering age and general health of our investigated...... population of patients. Only 2 patients could be sent home after operation, following a 14-day hospital stay. The analysis of this population of patients shows that a preexisting stress such as osteoporosis, a previous successful prosthesis replacement and loosening of the prosthesis increases the likelihood...... of an occurring periprosthetic fracture. The region around the tip of the prosthesis is particularly endangered to undergo a fracture in case of an impact. After the replacement of a prosthesis, older patients benefit from early mobility and exercise....

  12. Berührt sein – Ein Fallbericht zur Rolle von WATSU (WasserShiatsu) in der Rehabilitation nach Polytrauma

    OpenAIRE

    Schitter, Agnes Maria; Fleckenstein, Johannes

    2017-01-01

    Hintergrund: Die herausragende Bedeutung von Körperkontakt für den Menschen ist bekannt und nachgewiesen. Während aber intensiver Körperkontakt in der medizinischen Versorgung von Frühgeborenen etabliert ist, wird Berührung in schulmedizinische Therapiekonzepte für Erwachsene bisher nur marginal integriert. Massnahmen aus der Komplementärmedizin berücksichtigen den individuellen Bedarf an körperlicher Nähe und leisten einen klinischen Mehrwert für den Gesundungsprozess. In besonderer Weise...

  13. Visualisation of flux distributions in high-temperature superconductors. Final report; Sichtbarmachung der Flussverteilung in Hochtemperatursupraleitern nach verschiedenen Mikrostrukturaenderungen. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Kuhn, H.; Kronmueller, H.

    1998-05-01

    Theoretical calculation models for current, magnetic and electric field distributions in thin superconductors of arbitrary shape in perpendicular magnetic field were developed. Calculations were done for inhomogeneous and anisotropic critical currents and compared with magnetooptical observations of flux penetration. Nice agreement of theory and experiment was found. Flux-line depinning and motion in superconductors with linear defects was investigated by magneto-optics. Depinning mechanisms were deduced from observations of high-temperature superconductors which are irradiated with swift heavy ions parallel and crosswisely at various angles to the surface normal. Magneto-optical investigations of flux penetration into (Bi,Pb){sub 2}Sr{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10+{delta}} multifilament tapes showed a strong dependence of the current capability on the microstructure of single filaments. The different filament textures which are caused by the inhomogeneous deformation of the tape during thermomechanical treatment results in critical current densities varying by about one order of magnitude. (orig.) [Deutsch] Theoretische Modelle zur Berechnung von Strom-, Magnet- und elektrischen Feldverteilungen wurden fuer duenne Supraleiter beliebiger Geometrie mit inhomogener und anisotroper kritischer Stromdichte im senkrechten Magnetfeld entwickelt und mit magnetooptischen Beobachtungen des Flusseindringens verglichen, wobei eine hervorragende Uebereinstimmung zwischen Theorie und Experiment erzielt wurde. Mit Hilfe von magnetooptischen Untersuchungen des Flusseindringens in schwerionenbestrahlte Hochtemperatursupraleiter, die unter verschiedenen Winkeln zur Oberflaechennormalen parallel und kreuzweise bestrahlt wurden, konnten Bewegungs- und Entankerungsmechanismen von Flusslinien in Supraleitern mit linearen Defekten abgeleitet werden. Magnetooptische Untersuchungen des Flusseindringens in (Bi, Pb){sub 2}Sr{sub 2}Ca{sub 2}Cu{sub 3}O{sub 10+{delta}}-Multifilamentbandleiter zeigten, dass die Stromtragfaehigkeit sehr stark von der Mikrostruktur der einzelnen Filamente abhaengt. Die unterschiedliche Textur der Filamente, die aufgrund der inhomogenenen Verformung waehrend der thermomechanischen Behandlung entsteht, erzeugt Unterschiede in der kritischen Stromdichte von etwa einer Groessenordnung. (orig.)

  14. Early loss of teeth after treatment for childhood leukemia; Fruehzeitiger Zahnverlust nach Leukaemiebehandlung im Kindesalter. Fallbericht und Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Herrmann, T.; Doerr, W.; Lesche, A.; Lehmann, D. [Klinik und Poliklinik fuer Strahlentherapie und Radioonkologie, Medizinische Fakultaet der Technischen Univ. Dresden (Germany); Koy, S. [Klinik und Poliklinik fuer Mund-, Kiefer- und Gesichtschirurgie, Medizinische Fakultaet der Technischen Univ. Dresden (Germany)

    2004-06-01

    Background: only few reports of effects of radiotherapy in childhood on the dental apparatus are available in the literature. The basis for early loss of teeth appears to be a reduction of the root surface area after radiation exposure. These effects in the periodontium are a consequence of combined radiochemotherapy usually applied for treatment of childhood neoplasia. Chemotherapy alone also results in changes of periodontal development. Case report: a 33-year-old patient is reported, who, at the age of 11 years, received high-dose chemotherapy and radiotherapy of neuroaxis and cranium for acute lymphatic leukemia with relapse. The patient consulted the Implant Section of the Department of Oral and Maxillofacial Surgery because of severe dental changes and tooth loss despite adequate dental care and oral hygiene. Radiation doses given to the superior maxilla and mandible at the age of 11 were estimated to be in the range of 8-25 Gy. Conclusion: intense, life-long dental care and follow-up of patients cured from malignant disease in childhood must hence be postulated in order to minimize dental treatment sequelae by supportive measures, but also to initiate timely adequate dental and prosthetic management. (orig.)

  15. New developments in the German emergency planning as a consequence of Fukushima; Neue Entwicklungen im deutschen Notfallschutz nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Welte, Ulrike

    2015-06-01

    The analysis of the reactor accident in Fukushima Daiichi in March 2011 (lessons learned) in Germany and other countries has consequences for the national emergency planning in the respective governmental authorities. The contribution summarizes the most important aspects of the extended emergency plan concepts elaborated by the German SSK (Strahlenschutzkommission) and the RSK (Reaktorschutzkommission). The radiological principles were revised, recommendations concerning the monitoring and measuring equipment, accident scenarios for the emergency planning and measures for the post-accident phases are included in the concept.

  16. New media and their influence on the reporting after Fukushima; Neue Medien und ihr Einfluss auf die Berichterstattung nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Hampel, Gabriele [Axpo Power AG, Doettingen (Switzerland). Kernkraftwerk Beznau; Stieghorst, Christian [Mainz Univ. (Germany). Inst. fuer Kernchemie

    2014-10-01

    Subsequent to a comparison of classic conventional media with the new globalized 'Social Media' and their chances and risks it is dealt with the influence of the new media on the coverage of the Fukushima event. In particular, the difficulties of a serious reporting caused by the more and more pronounced lack of specialized journalists and of the usual specialized scientific terminology are pointed out. (orig.)

  17. Angiographic follow-up after carotid artery stenting of bifurcation stenosis; Angiographische Verlaufskontrolle nach Stentimplantation zur Behandlung der Karotisbifurkationsstenose

    Energy Technology Data Exchange (ETDEWEB)

    Hauth, E.A.; Forsting, M. [Inst. fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie, Universitaetsklinik Essen (Germany); Jansen, C.; Drescher, R.; Mathias, K. [Radiologische Klinik, Klinikum Dortmund (Germany); Schwarz, M. [Neurologische Klinik, Klinikum Dortmund (Germany); Christmann, A. [Fachbereich Statistik, Univ. Dortmund (Germany); Jaeger, H. [Radiologische Klinik, Klinikum Dortmund (Germany); Marien-Hospital Wesel, Praxis fuer Radiologie, Neuroradiologie and Nuklearmedizin (Germany)

    2006-08-15

    Purpose: the purpose of this prospective study was to determine the restenosis grade, the intima hyperplasia and the stent expansion via angiographic follow-up six months after carotid artery stenting. Materials and methods: in 100 patients, angiographic follow-up was performed 5.9 months (range: 2.9 - 11.4 months) after carotid artery stenting. The restenosis grade, the intima hyperplasia and the stent expansion were measured by selective angiography of the treated carotid artery. Results: the mean restenosis grade was 16% (range: 0 - 78%). In 6 of 100 patients (6%), a restenosis grade of > 50% was measured. In 4 patients the restenosis grade was 50 - 70%. In 2 patients the restenosis grade was > 70%. In 91 of 100 patients (91%), the restenosis was localized in the former area of stenosis of the carotid artery, and in 9 of 100 patients (9%), the restenosis was localized in the cranial stent end. The mean grade of intima hyperplasia was 31% (range: 2 - 70%). The mean increase in stent expansion at the time of follow-up was 10% (range: 0 - 59%). No correlation was able to be determined between the grade of stenosis and the grade of restenosis (rho = 0,017, range: -0.180 - 0.213), between the grade of residual stenosis and the grade of restenosis (rho = 0,257, range: 0.064 - 0.431) and between intima hyperplasia and the grade of restenosis (rho = 0,476, range: 0.309 - 0.615). Conclusions: carotid artery stenting is associated with a low incidence of high-grade restenosis 6 months after an intervention. The intima hyperplasia, which can be observed in each Wallstent, is partly compensated by the expansion of the self-expandable stent. Without a correlation between the grade of residual stenosis and the grade of restenosis, low-grade residual stenosis can be accepted. Therefore, we recommend undersized postdilation of the Wallstent. (orig.)

  18. PHILOSOPHIE(GESCHICHTE AUF GRUNDLAGE VON GAARDERS «SOFIES WELT» IM DAF-SACHUNTERRICHT NACH LDL

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    Guido Oebel

    2011-11-01

    Full Text Available : Thoroughly positive experience previously gained from both philosophical and issues of philosophical history in social study classes (cf. Hengelbrock 1991a; b; c; 1992; Heller 1994 convinced the author to even go beyond that by implementing Jostein Gaarder’s project idea “Sophie’s World” in a kind of special classroom of German as foreign language (cf. Oebel 2005a; b; c; 2007. In this context, Jean-Pol Martin’s “holistic approach” (Abendroth-Timmer LdL (“Learning-by-Teaching” for German “Lernen-durch-Lehren” seems to be the probably most emphatic constructivistic project teaching method (cf. Scheelhaas 1997; 2003; Wolff 2002, a fact that it has already proved impressively and sustainably not only in the follow-up project presently described but on several other occasions.

  19. Ein realer Lernort mit digitalem Mehrwert. Die Bibliothek der Universität Konstanz nach der Sanierung

    Directory of Open Access Journals (Sweden)

    Oliver Kohl-Frey

    2014-12-01

    Full Text Available Die Sanierung der Bibliothek der Universität Konstanz erforderte eine Überprüfung des bibliothekarischen Konzepts aus den sechziger Jahren, das in einem Gebäude der siebziger Jahre umgesetzt wurde. Insgesamt betrachtet bewährt sich das Konzept der Konstanzer Bibliothek bis heute, und es werden lediglich Anpassungen an die Bedürfnisse des 21. Jahrhunderts nötig. Durch aktive Pflege des gedruckten Bestands inklusive Aussonderung konnte Raum für die notwendige Ausweitung der Funktionen als Lernort und als sozialer Ort geschaffen werden. Das neu konzipierte Hybrid Bookshelf erlaubt eine neuartige Präsentation des digitalen Bestands am Ort Bibliothek. Durch die so angepasste Konzeption kann eine signifikante Aufwertung des realen Lernorts samt digitalem Mehrwert erreicht werden. The redevelopment process of the University of Konstanz Library required a proof of the sixties library concept that was realized within a seventies building. Generally the concept has proved itself; small adaptions have to be realized for the needs of the 21.century. The libraries functions as learning space and as social space are strengthened. Through the newly developed Hybrid Bookshelf the digital collection will be visible within the library space. That leads to a significant appreciation of the real learning space and a digital additional value.

  20. MR imaging of the knee following cruciate ligament reconstruction and meniscal surgery; MRT des Kniegelenks nach Kreuzband- und Meniskusoperationen

    Energy Technology Data Exchange (ETDEWEB)

    Woertler, K. [Technische Univ. Muenchen, Klinikum rechts der Isar (Germany). Inst. fuer Roentgendiagnostik

    2009-03-15

    Due to the increasing number of surgical procedures performed on the knee, MR imaging of the postoperative knee has gained more and more importance. For the evaluation of anterior cruciate ligament grafts and postoperative menisci, basic knowledge of surgical techniques is essential in order to differentiate normal postoperative findings from transplant failure, retears, and complications. This article reviews technical aspects of MR imaging following knee surgery, basic principles of operative techniques for anterior cruciate ligament reconstruction and therapy of meniscal tears, normal postoperative findings, MR imaging criteria for recurrent lesions, and findings with typical complications. (orig.)

  1. Julia Dombrowski: Die Suche nach der Liebe im Netz. Eine Ethnographie des Online-Datings. Bielefeld: transcript Verlag 2011.

    Directory of Open Access Journals (Sweden)

    Vanessa Kleinschnittger

    2011-09-01

    Full Text Available Julia Dombrowski setzt sich in ihrer Dissertation aus ethnologischer Perspektive mit dem Phänomen Online-Dating auseinander. Dabei legt sie einen Fokus auf die Emotionen, insbesondere die romantische Liebe, und widmet sich der Frage, auf welche Weise von den User/-innen der Datingbörsen kulturspezifische Liebesvorstellungen und individuelles Erleben bei ihrer Partnersuche vereinbart werden. Damit weicht Dombrowski von der bestehenden, sich vor allem auf Kapitalismuskritik konzentrierenden Forschung zum Online-Dating ab und sucht den Zugang zum Thema über das subjektive emotionale Erleben des Online-Datings durch die User/-innen selbst.In her dissertation, Julia Dombrowski discusses the phenomenon online-dating from an ethnological perspective. She focuses on emotions, particularly romantic love, and devotes her work to the question as to how users of dating sites reconcile culture specific ideas of love with individual experiences while dating. Thus Dombrowski departs from the existing studies on online dating, which concentrate mainly on the criticism of capitalism, and approaches the topic via the user’s subjective emotional perception of online dating.

  2. Climate protection after Copenhagen. International instruments and national implementation. Proceedings; Klimaschutz nach Kopenhagen. Internationale Instrumente und nationale Umsetzung. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    Gundel, Joerg; Lange, Knut Werner (eds.)

    2011-07-01

    The publication contains the results of the First Bayreuth Energy Law Days on the subject of 'Climate Protection after Copenhagen'. Following the UN climate conference of December 2009, it presents the current state of discussion of the legal instruments of climate protection on an international, European and national level. (orig./RHM)

  3. Experimental microangiography for measuring cerebral blood circulation following local cold stroke. Experimentelle Mikroangiographie der zerebralen Durchblutung nach lokalem Kaeltetrauma

    Energy Technology Data Exchange (ETDEWEB)

    Ruttmann, G

    1982-01-01

    In 54 female Wistar rats the exposed brain was right-parietally traumatised; cerebral perfusion of two anatomically different brain sections was angiographically imaged and densitometrically evaluated at various instants. The observation period ranged between 1 and 168 hours after the local cold stroke had been applied. Whereas in the telencephal section situated beyond the direct zone of lesion a maximum perfusion difference between the two hemispheres occurred already 1 hour after the animal had been traumatised, a maximum of perfusion difference was observed 6 hours after traumatisation in the diencephalic section situated directly across the site of the cold lesion. Within the first posttraumatic hours the total cerebral perfusion rapidly decreased. The minimum was reached 24 hours after traumatisation. Then it increased again and on the 7th posttraumatic day the perfusion level reached that of the control group. The tendencies of perfusion behaviour differing from one another, which were observed in both hemispheres, followed the course of the total perfusion. The decrease of perfusion occurring during the first hours after traumatisation is provoked by the compressive effect due to the expanding edema. This is principally indicated by the acute hyperperfusion during the first hours to be observed in the telencephalic section. The different velocities at which the hemispheres recover in the diencephalic section must be attributed to metabolic and hypoxic components. The incomplete recovery of perfusion in the injured hemisphere after 7 days may be due to the glial reaction.

  4. Radiation therapy with concurrent retrograde superselective intra-arterial chemotherapy for gingival carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Mukai, Y.; Hata, M.; Koike, I.; Inoue, T. [Yokohama City University Graduate School of Medicine, Department of Radiology, Kanazawa-ku, Yokohama, Kanagawa (Japan); Mitsudo, K.; Koizumi, T.; Oguri, S.; Kioi, M.; Tohnai, I. [Yokohama City University Graduate School of Medicine, Department of Oral and Maxillofacial Surgery, Yokohama, Kanagawa (Japan); Omura, M. [Shonankamakura General Hospital, Department of Radiation Oncology, Kamakura, Kanagawa (Japan)

    2014-02-15

    Docetaxel. Die Tumore wurden mit einer durchschnittlichen Gesamtdosis von 60 Gy in 30 Fraktionen bestrahlt. Eine komplette Remission (CR) wurde bei 29 der 34 Patienten (85 %) erzielt; 5 Patienten hatten Resttumore. Von den 29 Patienten mit einer CR wiesen 2 Patienten lokale Rezidive und 1 Patient 1-15 Monate nach der Behandlung Fernmetastasen auf. Nach einer durchschnittlichen Beobachtungszeit von 36 Monaten (12-79 Monate) hatten 26 der 36 Patienten ueberlebt; 4 Patienten verstarben an Krebs und 4 verstarben an anderen, nicht krebsbezogenen Ursachen. Sowohl 3 und 5 Jahre nach der Behandlung betrug die Gesamtueberlebensrate 79 % und die ursachenspezifische Ueberlebensrate 85 %. Eine Osteoradionekrose des Unterkiefers trat nach der Behandlung bei 1 Patienten auf. Die Strahlenbehandlung mit gleichzeitiger retrograder, superselektiver intraarterieller Chemotherapie war effektiv und sicher bei der Behandlung des Gingivakarzinoms. Diese Therapie kann eine vielversprechende, heilende und organsparende Behandlungsmoeglichkeit fuer Gingivakarzinome darstellen. (orig.)

  5. On the issue of higher human sensitivity to carcinogenic substances in early childhood; Zur Frage einer hoeheren Empfindlichkeit von Kindern gegenueber krebserzeugenden Stoffen

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, K [comp.

    1998-09-01

    . Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 22%. Inzidenz Hepatome: - Exposition ueber 4 Wochen ab Tag 1: 47,6%, - Exposition ueber 4 Wochen ab 13. Woche: 0%, - Exposition ueber 52 Wochen ab 13. Woche: 1,7%. (B) Diethylnitrosamin, Dyroff et al., 1986: (DEN + Phenobarbital), Hepatokarzinomen nach Exposition von Ratten ueber 6 Wochen: - beginnend im Alter von 4 Wochen: 100% Inzidenz, - beginnend im Alter von 8 Wochen: 0% Inzidenz. (C) Benz(a)pyren, Vesselinovitch et al., 1975: Lebertumoren nach einmaliger parenteraler Applikation an Ratten: - im Alter von 1 Tag: maennl.: 81% weibl.: 18%, - im Alter von 42 Tagen: maennl.: 9%, weibl.: 0%. Wie die Untersuchung von Maltoni et al. (1981) zu Vinylchlorid zeigt, kann bei gleicher Expositionskonzentration eine Exposition junger Tiere ueber einen kurzen Zeitraum zu einer hoeheren Tumorinzidenz fuehren als das Langzeitexperiment mit erwachsenen Tieren. Fuer alle Stoffe mit Ausnahme von Saccharin wurde eine gentoxische Wirkung nachgewiesen. Dies laesst vermuten, dass der Mechanismus der Kanzerogenese wesentlichen Einfluss auf die Altersabhaengigkeit hat. Dies steht in Einklang mit den mechanistischen Ueberlegungen. (orig.)

  6. Craniocerebral trauma. Magnetic resonance imaging of diffuse axonal injury; Schaedel-Hirn-Trauma. MRT bei diffuser axonaler Verletzung

    Energy Technology Data Exchange (ETDEWEB)

    Mallouhi, A. [Medizinische Universitaet Wien, Allgemeines Krankenhaus, Abteilung fuer Neuro- und Muskuloskelettale Radiologie, Klinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2014-09-15

    Acceleration-deceleration rotational brain trauma is a common cause of disability or death in young adults and often leads to a focal destruction of axons. The resulting pathology, axonal shear injury is referred to as diffuse axonal injury (DAI). The DAI-associated lesions occur bilaterally, are widely dispersed and have been observed in the surface and deep white matter. They are found near to and far from the impact site. When DAI is clinically suspected, magnetic resonance imaging (MRI) is the method of choice for further clarification, especially in patients where cranial computed tomography (CT) is inconspicuous. To investigate the presence of DAI after traumatic brain injury (TBI), a multimodal MRI approach is applied including the common structural and also functional imaging sequences. For structural MRI, fluid-attenuated inversion recovery (FLAIR) weighted and susceptibility contrast imaging (SWI) are the sequences mainly used. The SWI technique is extremely sensitive to blood breakdown products, which appear as small signal voids at three locations, at the gray-white interface, in the corpus callosum and in the brain stem. Functional MRI comprises a group of constantly developing techniques that have great potential in optimal evaluation of the white matter in patients after craniocerebral trauma. These imaging techniques allow the visualization of changes associated with shear injuries, such as functional impairment of axons and decreased blood flow and abnormal metabolic activity of the brain parts affected. The multimodal MRI approach in patients with DAI results in a more detailed and differentiated representation of the underlying pathophysiological changes of the injured nerve tracts and helps to improve the diagnostic and prognostic accuracy of MRI. When DAI is suspected multimodal MRI should be performed as soon as possible after craniocerebral injury. (orig.) [German] Das Rotationstrauma des Gehirns ist bei jungen Erwachsenen ein haeufiger Grund

  7. Long-term results of total body irradiation in adults with acute lymphoblastic leukemia

    Energy Technology Data Exchange (ETDEWEB)

    Marnitz, Simone; Zich, Alexander; Budach, Volker; Jahn, Ulrich; Neumann, Oliver [Charite University Medicine, Department of Radiation Oncology, Berlin (Germany); Martus, Peter [University Tuebingen, Institute of Clinical Epidemiology and Applied Biostatistics, Tuebingen (Germany); Arnold, Renate [Charite University Medicine, Campus CVK, Department of Hematology and Oncology, Bone Marrow Transplant Unit, Berlin (Germany)

    2014-05-15

    breadth. (orig.) [German] Ziel der Arbeit war die Auswertung der Akut- und Spaettoxizitaet sowie der Therapieergebnisse erwachsener Patienten mit akuter lymphatischer Leukaemie (ALL) nach Ganzkoerperbestrahlung (''total body irradiation'', TBI) als Teil des Therapiekonzepts. Im Rahmen einer retrospektiven Auswertung von 110 erwachsenen Patienten (34 ± 12 Jahre) mit ALL, die eine TBI (6-mal 2 Gy-12 Gy) vor Transplantation erhalten hatten, werden therapiebedingte Akut- und Spaettoxizitaet, Mortalitaet und Therapieergebnisse dargestellt. Die mittlere Nachbeobachtungszeit betrug 70 Monate. Die leukaemiefreien 2- und 5-Jahres-Ueberlebensraten betragen 78 bzw. 72 %. Nach im Median 7 Monaten erlitten 29 % (32/110) der Patienten ein medullaeres Rezidiv. Das Geschlecht war der einzige statistisch signifikante Faktor bezueglich des Gesamtueberlebens zugunsten der weiblichen Patienten. Die therapiebedingte Mortalitaets- und die Gesamtueberlebensraten nach 2 und 5 Jahren waren 16 und 22 %, bzw. 60 und 52,7 %. Die chronische ''Graft-versus-host''-Erkrankung (cGVHD) der Haut war die haeufigste Spaetreaktion (n = 33, 30 %), gefolgt von 15,5 % (17/110) pulmonaler cGVHD. Eine Lungenfibroseentwickelten 6 Patienten. Ophthalmologische Symptome berichteten 28 % (31/110); 11 % der Patienten (12/110) entwickelten eine symptomatische Osteoporose, 5/110 (4,5 %) eine Hypothyreose und 2 Patienten einen Diabetes mellitus. Von den maennlichen Patienten litten 11 % unter erektiler Dysfunktion oder Libidoverlust nach Therapie. Wegen menopausaler Beschwerden benoetigten 2/36 Frauen nach einer mittleren Zeit von 28 Monaten nach Therapie eine Hormonersatztherapie. Keine Patientin wurde nach Therapie schwanger. Es wurde weder eine akute noch eine spaete kardiale Toxizitaet dokumentiert, ebenso kein Sekundaermalignom. Obwohl das Therapieergebnis des vorliegenden Kollektivs im oberen Bereich der Literatur einzuordnen ist, bleiben sowohl die therapiebedingte

  8. Radiotherapeutic aspects of the treatment of adult patients with supradiaphragmatic Hodgkin's disease CS I/II. Pt. 1; Regarding the indications of primary and adjuvant radiotherapy. Fragen und Aspekte zur Radiotherapie bei erwachsenen Patienten mit lokalisierten supradiaphragmalen Stadien (CS I/II) eines Morbus Hodgkin. T. 1; Fragen und Aspekte zu den Indikationen einer primaeren und einer adjuvanten Radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Glanzmann, C. (Universitaetsspital, Klinik fuer Radio-Onkologie, Zurich (Switzerland)); Luetolf, U.M. (Universitaetsspital, Klinik fuer Radio-Onkologie, Zurich (Switzerland))

    1993-08-01

    Randomized studies of chemo- vs radiotherapy in patients with PS I/II A and some PS III A have shown conflicting results. Patients with supra-diaphragmatic Hodkin's disease and CS I/II can be subdivided according to radiotherapy as: 1. Patients with a very low or a low recurrence risk of approximately 10 to 20%: Patients less than 40 years old and CS I/II A NS/LP with less than three involved regions and no bulky mediastinal mass and an ESR below 30 mm. In the other patients, primary irradiation of an extended mantle field without a staging laparotomy is an acceptable primary treatment, achieving a recurrence-free survival rate of approximately 80%. Another option is a staging laparotomy with splenectomy and a mantle radiotherapy for PS I/II. Few groups prefer primary chemotherapy alone or some type of a reduced chemotherapy with lesser toxicity combined with localized radiotherapy and long-term observations of a larger group of patients after the last type of treatment have to confirm the excellent early results. 2. Patients with an intermediate recurrence risk of approximately 20 to 40%: Patients, who do not belong to group one or group 3. Patients less than 50 years old with CS I/II and an ESR less than 50 mm and without bulky mediastinal involvement and with one of the following signs: Three involved regions or MC or one B symptom. A patient with more than one of these signs or with two or three B symptoms should be classified in group 3. For these patients, we recommend staging laparotomy and radiotherapy if PS I/II or primary chemotherapy with or without radiotherapy of the involved regions. 3. Patients with a high recurrence risk (40% or higher): (Abstract Truncated)

  9. Die filmstilistische Darstellung von Klaras Gehbehinderung im Kinderfilm "Heidi"

    Directory of Open Access Journals (Sweden)

    Maria Ohrfandl

    2016-09-01

    Full Text Available Dieser Beitrag soll die Forschungslücke zur Darstellung von Behinderungen speziell im Kinderfilm im deutschsprachigen Raum füllen. Auf Basis einer neoformalistisch orientierten Filmanalyse nach Bordwell und Thompson (2008, wird anhand von drei Filmsequenzen eine mögliche Lesart des Kinderfilms "Heidi" (Marcus 2005 entwickelt, um die filmstilistische Darstellung der Gehbehinderung des Mädchens Klara zu untersuchen. Die Ergebnisse werden mit theoretischen Überlegungen zur Problematik der Begriffsbestimmung von Körperbehinderung sowie zur Mobilität und Selbstbestimmung von Menschen mit Körperbehinderungen in Bezug gesetzt. Dabei zeigt sich im Wesentlichen, dass im Kinderfilm "Heidi" (Marcus 2005 Klaras Gehbehinderung als 'heilbare Krankheit' und der Rollstuhl als Einschränkung von Mobilität begriffen wird. Außerdem unterliegt Klara aufgrund ihrer Körperbehinderung überwiegend der Fremdbestimmung von Erwachsenen. Zur Klärung wahrscheinlicher filmischer Bildungspotenziale werden die Ergebnisse schließlich anhand der von Jörissen und Marotzki (2009 entwickelten Orientierungsdimensionen "Wissens-, Handlungs-, Grenz- und Biographiebezug" diskutiert. This article aims to bridge a knowledge gap by showing ways of representing disabilities in the German children film genre. Using Bordwell and Thomson's (2008 neoformalistically orientated film analysis approach, the movie "Heidi" (Marcus 2005 is analysed. Bordwell and Thompson's (2008 method is applied to three sequences of "Heidi" in order to present an interpretation and to discuss the representation of Clara's walking impediment. The results are then associated with theoretical considerations regarding the mobility and self-determination of people with disabilities and problematic definitions of the term 'physical disability'. It is shown that characters in the children's film "Heidi" (Marcus 2005 regard Clara's walking impediment as a 'curable disease' and the wheelchair as a limitation

  10. (Kein Grund zur Homosexualität: Ein Plädoyer zum Verzicht auf psychogenetische Erklärungsversuche von homosexuellen, heterosexuellen und anderen Orientierungen

    Directory of Open Access Journals (Sweden)

    Ralf Binswanger

    2016-07-01

    Full Text Available Fritz Morgenthaler steht mit seinem Konzept der «Weichenstellungen » auf dem Boden von Freuds Postulat, wonach homosexuelle und heterosexuelle Orientierungen gleich erklärungsbedürftig sind. Allerdings können die «Weichenstellungen» weniger Hetero- oder Homosexualität per se erklären, sondern eher die verschiedenen Formen von Homo- und Heterosexualität in actu, wie sie in Fantasie und Verhalten gelebt werden. Mit Sexualität per se und Sexualität in actu sind zwei qualitativ verschiedene Gesichtspunkte benannt, unter denen Diskurse über manifeste und organisierte Sexualität sowie Perversionen mit Vorteil geführt werden. Dabei wird der Perversionsbegriff ausschliesslich der Sexualität in actu zugeordnet, welche als dialektische Einheit von sexuellen und nicht-sexuellen Funktionen aufgefasst wird. Pervers ist sexuelle Aktivität dann, wenn innerhalb dieser Einheit eine nicht-sexuelle Funktion die Priorität über die Triebbefriedigung hat. Sexualität per se bezeichnet Homosexualität, Heterosexualität, Fetischismus, Sadomasochismus, Pädophilie usw. als verschiedene erwachsene Sexualorganisationen – als hierarchische Organisation von Partialtrieben – auf «gleichberechtigter», entpathologisierter Ebene. Nachdem begründet wird, weshalb auch Judith Le Soldat den Grund zur Homosexualität per se anscheinend nicht gefunden hat und alle bisherigen psychogenetischen Herleitungen der verschiedenen erwachsenen Sexualorganisationen dieses Ziel verfehlen, empfiehlt sich ein grundsätzlicher Verzicht auf solche Erklärungsversuche – so wie es für die Heterosexualität per se meistens gehandhabt wird. Dagegen kann auf den u. a. von Robert Stoller verwendeten Begriff imprinting oder Prägung zurückgegriffen werden, welchen die Zürcher Analytiker Harold Lincke und Werner Fessler von jeglichem Biologismusverdacht befreit haben. Zum Schluss wird hervorgehoben, wie sehr Morgenthaler und Le Soldat mit ihrer Suche nach dem Grund zur

  11. Comparison of phosphorylation of ribosomal proteins from HeLa and Krebs II ascites-tumour cells by cyclic AMP-dependent and cyclic GMP-dependent protein kinases

    DEFF Research Database (Denmark)

    Issinger, O G; Beier, H; Speichermann, N

    1980-01-01

    Phosphorylation of eukaryotic ribosomal proteins in vitro by essentially homogeneous preparations of cyclic AMP-dependent protein kinase catalytic subunit and cyclic GMP-dependent protein kinase was compared. Each protein kinase was added at a concentration of 30nM. Ribosomal proteins were...... by the cyclic AMP-dependent enzyme. Between 0.1 and 0.2 mol of phosphate was incorporated/mol of these phosphorylated proteins. With the exception of protein S7, the same proteins were also major substrates for the cyclic GMP-dependent protein kinase. Time courses of the phosphorylation of individual proteins...... from the small and large ribosomal subunits in the presence of either protein kinase suggested four types of phosphorylation reactions: (1) proteins S2, S10 and L5 were preferably phosphorylated by the cyclic GMP-dependent protein kinase; (2) proteins S3 and L6 were phosphorylated at very similar rates...

  12. Enhanced casein kinase II activity during mouse embryogenesis. Identification of a 110-kDa phosphoprotein as the major phosphorylation product in mouse embryos and Krebs II mouse ascites tumor cells

    DEFF Research Database (Denmark)

    Schneider, H R; Reichert, G H; Issinger, O G

    1986-01-01

    Mouse embryos at various stages of development were used to study the relationship of protein kinase activities with normal embryogenesis. Casein kinase II (CKII) activity in developing mouse embryos shows a 3-4-fold activity increase at day 12 of gestation. Together with the CKII activity...... mouse tumour cells also show an enhanced CKII activity. Here too, a 110-kDa phosphoprotein was the major phosphoryl acceptor. Partial proteolytic digestion shows that both proteins are identical. Other protein kinases tested (cAMP- and cGMP-dependent protein kinases) only show a basal level of enzyme...

  13. Das Re-entry von Kritik: Assemblageforschung nach der Kritik an der Kritik. Kommentar zu Alexa Färbers „Potenziale freisetzen“

    Directory of Open Access Journals (Sweden)

    Hanna Göbel

    2014-05-01

    Full Text Available Der Kommentar zum Beitrag von Alexa Färber diskutiert eine Vermengung von drei unterschiedlichen Kritikbegriffen sowie Orten von Kritik in der aktuellen Debatte um die Assemblageforschung im Feld der Urban Studies. Ich rekonstruiere und unterscheide zwischen einem Kritikbegriff als theoretischer Norm, wie er von der (neo-marxistischen Stadt- und Raumforschung vertreten wird, und der ontologischen Kritik dieser Norm seitens der Assemblageforscher_innen. Alexa Färbers Beitrag zeigt drittens exemplarisch eine sich einschleichende normative Ebene in der Assemblageforschung auf, die bislang als Kritikform unterbelichtet geblieben ist. Diese wird als Wiedereinführung (re-entry von empirisch vollzogener Kritik in die Assemblageforschung bezeichnet. Damit ist eine theoretische Neupositionierung von Kritik ‚innerhalb’ einer Assemblage gemeint, indem Kritik nicht mehr als theoretische Norm ‚außerhalb’ zu verorten ist. In diesem Kommentar plädiere ich dafür, in der Assemblageforschung eine differenzierte Auseinandersetzung mit unterschiedlichen Begriffen und Orten von Kritik zu pflegen, um innerhalb der Urban Studies und für interessierte städtische Akteure mit urbaner Expertise (u.a. Architekt_innen, Planer_innen, Künstler_innen, Aktivist_innen, Kultur- und Sozialarbeiter_innen, DIY-Gemeinschaften klarer adressierbar zu sein.

  14. Radiation dose reduction in digital plain radiography of the knee after total knee arthroplasty; Dosisreduktion in der digitalen Radiografie des Kniegelenkes nach endoprothetischem Gelenkersatz

    Energy Technology Data Exchange (ETDEWEB)

    Kloth, J.K.; Kauczor, H.U.; Weber, M.A. [University Hospital Heidelberg (Germany). Clinic for Diagnostic and Interventional Radiology; Tanner, M.; Ewerbeck, V. [University Hospital Heidelberg (Germany). Center of Orthopedics, Trauma and Spinal Cord Injury; Stiller, W. [German Cancer Research Center (DKFZ), Radiology (E010), Heidelberg (Germany); Burkholder, I. [Univ. of Applied Sciences of the Saarland, Dept. of Nursing and Health, Saarbruecken (Germany)

    2015-08-15

    To reduce radiation exposure of frequently performed radiographs of the knee in follow-up of total-knee arthroplasty ensuring accurate assessment by using objective quality control criteria. In this prospective randomized study 278 radiographs of the knee in follow-up of total-knee arthroplasty were performed with standard and 37 % reduced radiation dose. The evaluation of the plain-radiographs was conducted using the following criteria: bone-implant interface, implant-surface character, implant-implant discrimination and periarticular heterotopic ossification. Two radiologists evaluated these criteria using a score ranging from 1 (definitely assessable) to 4 (not assessable). If a single criterion had been evaluated with a score ≥ 3 or more than 2 criteria with ≥ 2 points, the radiograph was score das ''not assessable''. The study was designed as non-inferiority-trial. 100 % of examined radiographs were scored as assessable, hence no statistical inferiority between the examinations with standard and reduced dose could be observed. Singular assessment of the defined criteria was likewise dose-independent. Plain-radiography of the knee following total-knee arthroplasty can be performed with 63 % of standard dose without loss of diagnostic validity.

  15. Regulation of glycogen synthase kinase-3{beta} (GSK-3{beta}) after ionizing radiation; Regulation der Glykogen Synthase Kinase-3{beta} (GSK-3{beta}) nach ionisierender Strahlung

    Energy Technology Data Exchange (ETDEWEB)

    Boehme, K.A.

    2006-12-15

    Glycogen Synthase Kinase-3{beta} (GSK-3{beta}) phosphorylates the Mdm2 protein in the central domain. This phosphorylation is absolutely required for p53 degradation. Ionizing radiation inactivates GSK-3{beta} by phosphorylation at serine 9 and in consequence prevents Mdm2 mediated p53 degradation. During the work for my PhD I identified Akt/PKB as the kinase that phosphorylates GSK-3{beta} at serine 9 after ionizing radiation. Ionizing radiation leads to phosphorylation of Akt/PKB at threonine 308 and serine 473. The PI3 Kinase inhibitor LY294002 completely abolished Akt/PKB serine 473 phosphorylation and prevented the induction of GSK-3{beta} serine 9 phosphorylation after ionizing radiation. Interestingly, the most significant activation of Akt/PKB after ionizing radiation occurred in the nucleus while cytoplasmic Akt/PKB was only weakly activated after radiation. By using siRNA, I showed that Akt1/PKBa, but not Akt2/PKB{beta}, is required for phosphorylation of GSK- 3{beta} at serine 9 after ionizing radiation. Phosphorylation and activation of Akt/PKB after ionizing radiation depends on the DNA dependent protein kinase (DNA-PK), a member of the PI3 Kinase family, that is activated by free DNA ends. Both, in cells from SCID mice and after knockdown of the catalytic subunit of DNA-PK by siRNA in osteosarcoma cells, phosphorylation of Akt/PKB at serine 473 and of GSK-3{beta} at serine 9 was completely abolished. Consistent with the principle that phosphorylation of GSK-3 at serine 9 contributes to p53 stabilization after radiation, the accumulation of p53 in response to ionizing radiation was largely prevented by downregulation of DNA-PK. From these results I conclude, that ionizing radiation induces a signaling cascade that leads to Akt1/PKBa activation mediated by DNA-PK dependent phosphorylation of serine 473. After activation Akt1/PKBa phosphorylates and inhibits GSK-3{beta} in the nucleus. The resulting hypophosphorylated form of Mdm2 protein is no longer able to degrade p53 which in consequence accumulates in the nucleus. (orig.)

  16. Accident analyses in nuclear power plants following external initiating events and in the shutdown state. Final report; Unfallanalysen in Kernkraftwerken nach anlagenexternen ausloesenden Ereignissen und im Nichtleistungsbetrieb. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Loeffler, Horst; Kowalik, Michael; Mildenberger, Oliver; Hage, Michael

    2016-06-15

    The work which is documented here provides the methodological basis for improvement of the state of knowledge for accident sequences after plant external initiating events and for accident sequences which begin in the shutdown state. The analyses have been done for a PWR and for a BWR reference plant. The work has been supported by the German federal ministry BMUB under the label 3612R01361. Top objectives of the work are: - Identify relevant event sequences in order to define characteristic initial and boundary conditions - Perform accident analysis of selected sequences - Evaluate the relevance of accident sequences in a qualitative way The accident analysis is performed with the code MELCOR 1.8.6. The applied input data set has been significantly improved compared to previous analyses. The event tree method which is established in PSA level 2 has been applied for creating a structure for a unified summarization and evaluation of the results from the accident analyses. The computer code EVNTRE has been applied for this purpose. In contrast to a PSA level 2, the branching probabilities of the event tree have not been determined with the usual accuracy, but they are given in an approximate way only. For the PWR, the analyses show a considerable protective effect of the containment also in the case of beyond design events. For the BWR, there is a rather high probability for containment failure under core melt impact, but nevertheless the release of radionuclides into the environment is very limited because of plant internal retention mechanisms. This report concludes with remarks about existing knowledge gaps and with regard to core melt sequences, and about possible improvements of the plant safety.

  17. Subjective perception of radioactivity. No change post successful treatment with radioiodine; Strahlen bleiben boese. Keine Aenderung der subjektiven Konzepte von Radioaktivitaet nach erfolgreicher Radioiodtherapie

    Energy Technology Data Exchange (ETDEWEB)

    Freudenberg, L.S.; Mueller, S.P.; Beyer, T.; Bockisch, A. [Universitaetsklinikum Essen (Germany). Klinik fuer Nuklearmedizin

    2009-07-01

    We assess the attitude of patients with thyroid disease towards radiation and radioactivity before and after radioiodine therapy by means of a cultural-anthropological approach. We evaluate in patient interviews how their subjective attitude towards radioactivity as an abstract term and towards radioactivity in the medical context on the basis of their personal experiences with radionuclide therapy. 29 patients with autonomously functioning thyroid lesions (17 women, 12 men, 35-79 years) were included in this study. All patients were interviewed prior to and 22-27 month post radioiodine therapy in an open dialogue with the principal investigator. Patients were asked to describe their attitude towards radioactivity in general and towards radioiodine therapy in particular. Patients were asked to use a scoring system (1: positive, 5: negative) to quantify their perception of radioactivity. The personal perception of radioactivity as an abstract term does not change significantly (p = 0.15) before and after radioiodine therapy. This perception is linked to mostly negative impressions of radiactivity. However, patients become more positive when assessing the value of radioactivity as part of their therapy regimen. Thus, we observe a significant increase in percepted value of radioactivity post radioiodine therapy (p = 0.03). Patients continue to view radioactivity as something negative despite treatment success following radioiodine therapy. Our results provide useful information for patient information by the nuclear medicine physician prior to a radioiodine therapy. (orig.)

  18. Role velikosti buněk ve změnach velikosti těla živočichů

    OpenAIRE

    Hájková, Věra

    2017-01-01

    Animals are very variable in body size. Differences in body size are visible not only at the interspecific level but also within species, whether they are differences in size during ontogeny or among individuals of the same species exposed to different environmental conditions. The size of the organism depends on the size and number of the basic units from which it is built, i.e. the cells. From this perspective body size can be changed only in three ways: by changing the cell size, by changi...

  19. Negotiation time table and realization timetable in the grid connection process according to KraftNAV; Verhandlungs- und Realisierungsfahrplan im Netzanschlussverfahren nach der KraftNAV

    Energy Technology Data Exchange (ETDEWEB)

    Buchmann, Felix [Sozietaet Alber Buchmann Stefan Rechtsanwaelte, Reutlingen (Germany)

    2010-04-15

    With the ordinance for the regulation of the grid connection from plants of power production (KraftNAV), the conditions of the grid connection were concretized by power station projects with a nominal output of at least 100 MW with an electrical potential of at least 110 kV. Under this aspect, the author of the contribution under consideration reports on the negotiation timetable and realization timetable in the grid connection procedure according to the KraftNAV. The following aspects are treated: Procedure for the grid connection according to KraftNAV in the overview; Promise of the connection and reservation fee; Negotiation timetable; Realization timetable; Requirement timetable; Duties to supply information.

  20. Levels of concern for radioactive contaminations in soil according to soil protection standards; Besorgniswerte fuer Radionuklide in Boeden nach bodenschutzrechtlichen Massstaeben

    Energy Technology Data Exchange (ETDEWEB)

    Gellermann, R. [Nuclear Control and Consulting GmbH, Braunschweig (Germany); Barkowski, D.; Machtolf, M. [IFUA-Projekt-GmbH Bielefeld (Germany)

    2016-07-01

    In the paper the question is examined whether the established soil protection standards for carcinogenic substances are also applicable to the assessment of radioactive soil contamination. Referring to the methods applied in soil protection for evaluation of dose-effectrelations and estimations of carcinogenic risks as well as the calculation methods for test values in soil protection ''levels of concern'' for soil contamination by artificial radionuclides are derived. The values obtained are significantly larger than the values for unrestricted clearance of ground according to the German Radiation Protection Ordinance (StrlSchV). The thesis that soil is protected according to environmental standards provided that radiation protection requirements are met needs further checks but can be probably confirmed if the radiation protection requirements are clearly defined.

  1. Total nuclear phaseout. 30 years after Chernobyl. What still has to be done; Alle aussteigen. 30 Jahre nach Tschernobyl. Was noch zu tun ist

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2016-03-15

    The brochure of the German Federal Environment Ministry on the necessity of total nuclear phaseout 30 years after Chernobyl discusses the following issues that still have to be done: Search for a final repository in deep rocks, building of a steel dome for Chernobyl and the roadmap for nuclear phaseout.

  2. Precise explosive force determination of the first A-bomb 70 years after the explosion; Genaue Sprengkraftbestimmung der ersten A-Bombe 70 Jahre nach der Explosion

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    2016-11-01

    This short note provides a reference to an American magazine article [Susan K. Hanson et al., Proc. Natl. Acad. Sci. U.S.A. 113, 8104 (2016) - 4933] in which an approach to measuring extinct fission products is described that would allow for the characterization of a nuclear test at any time. The isotopic composition of molybdenum in five samples of glassy debris from the 1945 Trinity nuclear test has been measured. Non-natural molybdenum isotopic compositions were observed, reflecting an input from the decay of the short-lived fission products {sup 95}Zr and {sup 97}Zr. By measuring both the perturbation of the {sup 95}Mo/{sup 96}Mo and {sup 97}Mo/{sup 96}Mo isotopic ratios and the total amount of molybdenum in the Trinity nuclear debris samples, it is possible to calculate the original concentrations of the {sup 95}Zr and {sup 97}Zr isotopes formed in the nuclear detonation. Together with a determination of the amount of plutonium in the debris, these measurements of extinct fission products allow for new estimates of the efficiency and yield of the historic Trinity test.

  3. Dismantling techniques for plutonium-contaminated gloveboxes: experience from first year of decommissioning; Zerlegungstechniken fuer Pu-kontaminierte Handschuhkaesten: Erfahrungsbericht nach einem Jahr Rueckbau

    Energy Technology Data Exchange (ETDEWEB)

    Baumann, R.; Faber, P. [Siemens Power Generation, Decommissioning Projects, Hanau (Germany)

    2003-07-01

    At the mixed-oxide (MOX) processing facility formerly operated by ALKEM GmbH in Hanau, Germany - which was taken over to Siemens in 1988 and renamed Siemens' Hanau Fuel Fabrication Plant, MOX facility - around 8500 kg of plutonium were processed to make MOX fuel rods and fuel assemblies since production started in 1965. After shutdown of the facility by the authorities in mid-1991 for political reasons, the remaining nuclear fuel materials were processed during the subsequent ''cleanout'' phase starting in 1997 into rods and assemblies suitable for long-term storage. The last step in cleanout consisted of ''flushing'' the production equipment with depleted uranium and thoroughly cleaning the gloveboxes. During cleanout around 700 kg of plutonium were processed in the form of mixed oxides. The cleanout phase including the subsequent cleaning and flushing operations ended on schedule in September 2001 without any significant problems. Starting in mid-1999, the various glovebox dismantling techniques were tested using uncontaminated components while cleanout was still in progress and then, once these trials had been successfully completed, further qualified through use on actual components. The pilot-phase trials required four separate licenses under Section 7, Subsection (3) of the German Atomic Energy Act. Thanks to detailed advance planning and experience from the pilot trials the individual dismantling steps could be described in sufficient detail for the highly complex German licensing procedure. The first partial license for decommissioning the MOX facility under Sec. 7, Subsec. (3) of the Atomic Energy Act was issued on May 28, 2001. It mainly covers dismantling of the interior equipment inside the gloveboxes a well as the gloveboxes themselves. Actual decommissioning work inside the former production areas of the MOX facility started on a large scale in early September 2001. (orig.)

  4. Estimation of dose rate of a package ({sup 223+}Ra) and evaluation of transport index; Dosisleistungsabschaetzung bei einem Versandstueck ({sup 223+}Ra) und Ermittlung der Transportkennzahl nach ADR

    Energy Technology Data Exchange (ETDEWEB)

    Bittner, Michael [TUEV SUED Industrie Services GmbH, Region Nordost, Leipzig (Germany). Anlagensicherheit/Strahlenschutz; Richter, Jens [TUEV SUED Industrie Services GmbH, Region Nordost, Dresden (Germany). Anlagensicherheit/Strahlenschutz

    2016-08-01

    The transport index of a package is to be determined according to provisions of the ADR. It is directly related to the maximum radiation level in mSv/h at a distance of 1 m from the external surface of the package or pallet. To evaluate the existing distribution of the dose equivalent outside the package or pallet calculations of photon dose rates are required. For Monte-Carlo simulations with MCNP5 a three-dimensional model of a package containing Xofigo trademark was created, which contains all relevant sources from {sup 223}Ra and its decay chain.

  5. The liability according to paragraph 26 of the German Atomic Energy Act. A wallflower?; Die Haftung nach paragraph 26 AtG. Ein Mauerbluemchen?

    Energy Technology Data Exchange (ETDEWEB)

    Raetzke, Christian [CONLAR Consulting on Nuclear Law and Regulation, Leipzig (Germany)

    2018-02-15

    According to German law, liability for damage caused by radioactivity can arise from several regulations. In most cases, liability under the Paris Convention on Third Party Liability in the Field of Nuclear Energy, which applies in the field of nuclear power, is at the forefront of discussion. According to paragraph 26 of the German Atomic Energy Act, liability is somewhat in the shadow of the Paris Convention. It applies to the handling of radioactivity in medicine, research and industry (e.g. for test emitters) as well as activities involving natural and depleted uranium and nuclear fusion. The article outlines the basic elements of liability under Section 26 of the German Atomic Energy Act, which may become increasingly important in future due to recent developments such as the phasing out of nuclear power in Germany.

  6. The German ''Energiewende''. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-08-01

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German ''Energiewende''. The result is clear-cut: The German ''Energiewende'' is inadequate. Due to the cap-and-trade system of the EU the '''Energiewende''.

  7. Postoperative and posttherapeutic changes after primary bone tumors. What's important for radiologists?; Postoperative und posttherapeutische Veraenderungen nach primaeren Knochentumoren. Was ist wichtig fuer den Radiologen

    Energy Technology Data Exchange (ETDEWEB)

    Grieser, T. [Klinikum Augsburg, Klinik fuer Diagnostische und Interventionelle Radiologie und Neuroradiologie, Augsburg (Germany); Noebauer-Huhmann, I.M. [Med. Universitaet Wien, Univ.-Klinik fuer Radiologie und Nuklearmedizin, Wien (Austria)

    2017-11-15

    Posttreatment imaging of primary bone tumours represents a diagnostic challenge for radiologists. Depending on the primary bone tumour common radiological procedures, such as radiography, computed tomography (CT), and magnetic resonance imaging (MRI), are employed. Radiography and CT are particularly useful in benign bone tumours and in matrix-forming bone tumours. MRI comes into consideration with malignant tumour recurrence and tumoral soft tissue infiltration. Bone scintigraphy is of superior importance if a primarily multifocal manifestation of bone tumour or metastasizing tumour disease is suspected. Molecular imaging (FDG-PET and hybrid imaging, using CT) are gaining increasing importance in light of monitoring neoadjuvant chemotherapy and detecting recurrent tumour appearance. The current literature shows sensitivity and specificity values for recurrent detection of up to 92% and 93%. Diagnostic accuracy is as high as 95%, thus, exceeding accuracy values for CT (67%) and MRI (86%) by far. Likewise, this is also applicable for the assessment of the neoadjuvant chemotherapy. Moreover, PET-based modalities are able to establish prognostic statements using SUV-threshold values at baseline (especially for Ewing sarcomas). Advanced imaging techniques have made a great diagnostic step forward and have proven to be relevant and reproducible with respect to both relapse detection and treatment assessment. Furthermore, it is not clear whether a higher detection rate of early tumour recurrence will inevitably lead to better outcome and survival. (orig.) [German] Die posttherapeutische Bildgebung primaerer Knochentumoren stellt eine diagnostische Herausforderung fuer jeden Radiologen dar. In Abhaengigkeit vom primaeren Knochentumor werden zur Nachsorge die gaengigen radiologischen Standardverfahren eingesetzt (Projektionsradiographie, Computertomographie [CT] und Magnetresonanztomographie [MRT]). Die Projektionsradiographie und CT haben einen besonderen Stellenwert v. a. bei benignen Knochentumoren sowie bei primaer matrixbildenden Knochentumoren. Die MRT kommt vorzugsweise zur Rezidivdiagnostik bei malignen Knochentumoren und weichteilig rezidivierender Tumoren zum Einsatz. Knochenszintigraphische Verfahren sind vorteilhaft, wenn eine primaer multifokale Manifestation der Knochentumorkrankheit vorliegt bzw. eine Metastasierung vermutet wird. Die molekulare Bildgebung (Fluordesoxyglucose-Positronenemissionstomographie [FDG-PET] bzw. ihre Hybridbildgebung in Kombination mit der CT) spielt eine zunehmende Bedeutung hinsichtlich des neoadjuvanten Therapiemonitorings und der Rezidivfrueherkennung. Die aktuelle Literatur fuehrt fuer die molekularen Bildgebungstechniken (PET, PET-CT) Sensitivitaeten und Spezifitaeten bzgl. der Rezidiverkennung von bis zu 92 % bzw. 93 % an. Die diagnostische Genauigkeit wird mit bis zu 95 % angegeben, was sowohl diejenige des CT mit 67 % und jene der MRT mit 86 % deutlich uebertrifft. In aehnlicher Weise trifft dies auch fuer die Beurteilung der neoadjuvanten Therapie zu, wobei hier die PET-basierten Verfahren mit Hilfe praetherapeutischer SUV-Werte (''standard uptake value'') prognostisch verwertbare Aussagen machen koennen (v. a. fuer Ewing-Sarkome). Die modernen Bildgebungsverfahren haben ihren Fortschritt hinsichtlich Rezidivdiagnostik und der Einschaetzung des Therapieansprechens valide und reproduzierbar unter Beweis gestellt. (orig.)

  8. The Chernobyl reactor accident, ten years on. Teaching projects for mathematics instruction in interdisciplinary working groups; 10 Jahre nach Tschernobyl. Unterrichtsprojekte fuer den Mathematikunterricht in faecheruebergreifenden Kooperationen

    Energy Technology Data Exchange (ETDEWEB)

    Boer, H. [comp.; Delle, E. [comp.; Mies, K. [comp.; Warmeling, A. [comp.

    1996-10-01

    The booklet presents background information and addresses the following aspects: ionizing radiation and radiation effects; safety of German nuclear power plants; statistical evidence of radiation injuries; short-lived and long-lived ionizing radiation; radioactive waste; CO{sub 2} emissions as an argument in favour of nuclear power generation. The material presented is intended for use by a school project team interested in the subjects, or as a basis for collaborative, interdisciplinary teaching in working groups, and it offers information and problems for mathematics teaching. (HP) [Deutsch] Neben vielen Informationen behandelt die Broschuere: Strahlen und Strahlenwirkungen; Sicherheit deutscher Kernkraftwerke; statistischer Nachweis von Strahlenschaeden; Kurz- und Langfestigkeit der Strahlenbelastung; radioaktiver Abfall; CO{sub 2}-Problematik als Argument fuer die Kernenergie. Die Broschuere ist gedacht z.B. fuer eine Projektgruppe, einen Projekttag, fuer eine Lerngruppe in faecheruebergreifender Kooperation. Die Materialien sind ausgearbeitet fuer die Themembearbeitung im Mathematikunterricht mit Uebungsaufgaben. (HP)

  9. Costs and role of ultrasound follow-up of polytrauma patients after initial computed tomography; Kosten und Stellenwert von Ultraschallverlaufskontrollen bei polytraumatisierten Patienten nach initialer Computertomografie

    Energy Technology Data Exchange (ETDEWEB)

    Maurer, M.H.; Winkler, A.; Powerski, M.J.; Elgeti, F.; Huppertz, A.; Roettgen, R.; Marnitz, T. [Charite - Universitaetsmedizin Berlin (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie; Wichlas, F. [Charite - Universitaetsmedizin Berlin (Germany). Centrum fuer Muskuloskeletale Chirurgie

    2012-01-15

    Purpose: To assess the costs and diagnostic gain of abdominal ultrasound follow-up of polytrauma patients initially examined by whole-body computed tomography (CT). Materials and Methods: A total of 176 patients with suspected multiple trauma (126 men, 50 women; age 43.5 {+-} 17.4 years) were retrospectively analyzed with regard to supplementary and new findings obtained by ultrasound follow-up compared with the results of exploratory FAST (focused assessment with sonography for trauma) at admission and the findings of whole-body CT. A process model was used to document the staff, materials, and total costs of the ultrasound follow-up examinations. Results: FAST yielded 26 abdominal findings (organ injury and/or free intra-abdominal fluid) in 19 patients, while the abdominal scan of whole-body CT revealed 32 findings in 25 patients. FAST had 81 % sensitivity and 100 % specificity. Follow-up ultrasound examinations revealed new findings in 2 of the 25 patients with abdominal injuries detected with initial CT. In the 151 patients without abdominal injuries in the initial CT scan, ultrasound follow-up did not yield any supplementary or new findings. The total costs of an ultrasound follow-up examination were EUR 28.93. The total costs of all follow-up ultrasound examinations performed in the study population were EUR 5658.23. Conclusion: Follow-up abdominal ultrasound yields only a low overall diagnostic gain in polytrauma patients in whom initial CT fails to detect any abdominal injuries but incurs high personnel expenses for radiological departments. (orig.)

  10. Optimierung der Photonenselektion für die Suche nach dem Zerfall des Higgsbosons in zwei leichte CP-ungerade Skalare

    CERN Document Server

    Braren, Früd; Schleper, Peter

    In some extensions of the Standard Model, extended Higgs sectors are postulated, from which, in addition to the Standard Model-like Higgs boson, a new CP-odd scalar arises. If this scalar’s mass is small, final states consisting of two photon pairs would be generated by the decay of the Higgs boson into two of the above mentioned scalars and the subsequent decays of the scalars into photon pairs. In the ATLAS detector, such a pair of photons would be reconstructed as a single photon. In order to analyse the data generated by the ATLAS detector at the LHC, one needs to know the efficiency of the photon pairs to be identified as a single photon. Using Monte-Carlo simulations, this identification efficiency is calculated and analysed for several photon selections and for three different masses of the scalar in the mass range of 100 to 400 MeV. This leads to the creation of an optimized cut menu for this final state. The aim of this is to make the analysis of the ATLAS-generated data with regard to this special...

  11. Aspects of reactor dismantling planning following the safe entombment in the NPP Lingen (KWL); Aspekte der Abbauplanung nach dem Sicheren Einschluss im Kernkraftwerk Lingen (KWL)

    Energy Technology Data Exchange (ETDEWEB)

    Priesmeyer, U.; Rojahn, T.; Fries, B. [Kernkraftwerk Lingen GmbH (Germany)

    2009-07-01

    The NPP Lingen (KWL) was shut-down in 1977. Due to the fact that no final repository was available the safe entombment for 25 years was chosen following the decommissioning. The conventional plant components were dismantled and removed from the plant site. The licensing procedure for reactor dismantling with final disposal in Schacht Konrad has been started. The beginning of dismantling operation is scheduled for 2013. The authors describe the preparatory work, the boundary conditions for the dismantling, radiation protection considerations with respect to manual demolition work after the rather long decay time.

  12. Go west : internal migration in Germany after reunification Go West : interregionale Migration in Deutschland nach der Wiedervereinigung

    Directory of Open Access Journals (Sweden)

    Birgit Glorius

    2012-12-01

    Full Text Available The paper wants to shed light on the phenomenon of internal migration in Germany after the fall of the iron curtain. Since German reunification, the eastern part of Germany lost a large share of its population due to internal migration. Whereas in the beginning, departures were spread evenly over all age and educational groups and were accompanied by a significant counter-stream, in the course of time the negative migration balance was mainly produced by younger people at the beginning of their professional career. The paper describes the development of internal east-west migration in detail and presents primary data on the profiles of young migrants drawn from a research project during the years 2004-2007 (in this research project, financed by the German Research Foundation DFG, data were gathered from 1,200 migrants aged between 18-35 who moved from the federal state Sachsen-Anhalt to the western part of Germany. Hereby, special emphasis will be given to the methodological implications of studying selective migration processes. Final conclusions are drawn regarding the regional assessment and theoretical classification of this migration process, but also on the theoretical and methodological constraints of mobility research.Seit der deutschen Wiedervereinigung hat Ostdeutschland beträchtliche Bevölkerungs­verluste aufgrund von innerdeutschen Wanderungen zu verzeichnen. Während der Migrationsstrom zunächst relativ gleichmäßig über alle Bevölkerungsgruppen hinsichtlich Alter und Bildungsstand verteilt war und überdies von einem signifikanten Gegenstrom begleitet wurde, hat er sich im Laufe der 1990er Jahre ausdifferenziert. Die negative Wanderungsbilanz ist heute vor allem durch die Abwanderung junger Menschen zu Beginn des Erwerbslebens gekennzeichnet. Der Beitrag bietet eine detaillierte Beschreibung der innerdeutschen Ost-West-Wanderung und präsentiert empirische Primärdaten zu den Profilen junger Ost-West-Migranten aus Sachsen-Anhalt (die Daten stammen aus einer durch die Deutsche Forschungsgemeinschaft DFG finanzierten Studie zur innerdeutschen Ost-West-Wanderung, die 1.200 junge Abwanderer zwischen 18 und 35 Jahren umfasste. Die abschließende Generalisierung gibt Hinweise bezüglich der spezifischen geographischen Kompetenzen – aber auch der Fallstricke – im Bereich der internationalen und intra-nationalen Migrationsforschung.

  13. The zero-point field. On the search for the cosmic basic energy; Das Nullpunkt-Feld. Auf der Suche nach der kosmischen Ur-Energie

    Energy Technology Data Exchange (ETDEWEB)

    McTaggart, L.

    2007-02-15

    Does an inexhaustable energy source exist from which all life is fed? A form of energy, which penetrates all dead and living expression forms of life? Does a logical, scientific explanation exist for parapsychological phenomena like clairvoyance, telepathy, ghost healing, synchronicity, and a model for the mode of action of homeopathy? Do serious researchers and scientific studies to be token in ernest exist, which not only deal with this questions but also have found answers? During eight years the British scientific journalist Lynne McTaggart has researched. ''Teh zero-point field'' is the result of numerous speeches with renowned physicists, biophysicists, neuroscientists, biologist, and consciousness researchers on the whole world, which have independently discovered phenomena, which are combined like puzzle pieces to a fascinating total picture.

  14. Outsourcing Marketing Activities - a strategic option for energy suppliers. Increasing efficiency and reducing costs; Netzvertraeglichkeitspruefungen nach dem Erneuerbare-Energien-Gesetz. Verpflichtung zur Vorlage der Netzdaten

    Energy Technology Data Exchange (ETDEWEB)

    Weissenborn, C. [Bereich Recht und Umwelt, Verband der Elektrizitaetswirtschaft - VDEW - e.V., Berlin (Germany)

    2006-07-03

    The transfer or certain functions in a company which do not belong to the originary core of the business to specialists has becom a normal attitude in economy nowadays. Thus it is no longer something special to decide for outsourcing facturing, personnel, legal or IT service departments. Up to now, marketing was not included in such considerations, not in energy industry at least. The following article shows that this might change in the years to come and explains which advantages could be achieved by outsourcing marketing activities and transferring them to third parties.

  15. Electricity labelling according to paragraph 42 EnWG. Amendments in EnWG 2011; Stromkennzeichnung nach paragraph 42 EnWG. Neuerungen im EnWG 2011

    Energy Technology Data Exchange (ETDEWEB)

    Germer, Christoph [Gersemann und Kollegen, Freiburg im Breisgau (Germany); Reh, Matthias [enwima AG, Berlin (Germany)

    2012-07-01

    Labelling of electric power is based on the assumption that the end user needs at least one criterion other than the price to distinguish between electric power offered by different providers. The regulations, especially those governing the labelling of electric power from renewable energy sources, have been modified significantly in EnWG 2011. (orig.)

  16. Provision of regulating energy in the context of direct marketing according to the EEG 2012; Zur Bereitstellung von Regelleistung im Rahmen der Direktvermarktung nach dem EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Breuer, Daniel [Landgericht Koeln (Germany); Osborne Clarke, Koeln (Germany)

    2012-07-01

    Electric power from wind power plants and photovoltaic power plants cannot be stored and is not available at all times. The results are volatile power supply curves, risks of availability forecasting for grid owners or (direct) marketers, and enhanced requirements on grid operation with stable frequency. All this will directly affect the reliability of power supply in Germany. Grid integration and market integration of renewable energy sources are directly connected. The contribution discusses the challenges of ensuring grid stability as well as the legal regulations governing the supply of regulating power from renewable energy sources. Since 1 January 2012, regulating power from renewable energy sources is provided within the scope of the EEG only by direct marketing, i.e. without receiving fixed reimbursement rates. Direct marketing is only possible outside the scope of the EEG, but this is without relevance for the time being. (orig.)

  17. In search of supply concepts for the mass market in the face of the energy turnaround; Auf der Suche nach massenmarktfaehigen Belieferungskonzepten fuer die Energiewende

    Energy Technology Data Exchange (ETDEWEB)

    Fest, Claus [RWE Effizienz GmbH, Dortmund (Germany); Ploch, Dieter [eprimo GmbH, Neu-Isenburg (Germany)

    2013-01-15

    There are increasing demands both in Germany and at the European level that electricity price models for household and industrial customers should be brought in line with the times by allowing greater flexibility and allocating costs to causes. In Germany they have issued from the discussion over the consequences of the energy turnaround for the mass customer business and the associated search for viable supply concepts. A number of proposals have been made to this end, largely revolving around the question of how prices for supplying end customers can be made to more closely approximate conditions as they prevail in the wholesale market while allowing price advantages to become effective. However, in many instances the public debate has so far neglected an essential factor: In order for a product to become firmly established on the market it must confer benefits to all involved, that is to both customers and suppliers.

  18. Length change of the alloys Waspaloy and Inconel 718 after long-term annealing; Laengenaenderung der Legierungen Waspaloy und Inconel 718 nach Langzeitauslagerung

    Energy Technology Data Exchange (ETDEWEB)

    Kinzel, Svenja

    2016-07-01

    Within the scope of this work the contraction behavior of Ni-based superalloy Waspaloy could in detail be referred to a combination of different microstructural changes and the results could partially be transferred to Ni-Fe-based alloy Inconel 718. Isothermal annealing of sample rods at temperatures between 450 C and 750 C induces an average relative length contraction of about -2.10{sup -4}. It is apparent that contraction is more pronounced for lower temperatures (-3.10{sup -4} at 550 C) than for higher ones (-1.10{sup -4} at 750 C). Within the first 300 hours of annealing the contraction reaches about 70-75% of the value measured after 10,000 hours. This means the major part of the effect takes place at the beginning of long term annealing but even after 10,000 hours no saturation occurs. On the basis of lattice parameter measurements it could be found that within the first 300 hours a significant lattice parameter decrease of matrix and γ{sup '} phase emerged. Longer annealing time does not cause further lattice contraction. This sample behavior can be explained by temperature dependence of phase fractions and phase compositions. Thermodynamic calculations as well as stereological analysis of micrographs show a decrease of stable γ{sup '}-phase content with increasing temperature. In parallel, TEM-EDS measurements and calculated phase fractions show concentration fluctuations due to the different precipitate fraction, which cause contraction of the lattice parameter. Furthermore, within the first 100 hours at temperatures up to 650 C the formation or Ni-Cr rich domains could be observed. As these domains exhibit a smaller lattice parameter than the matrix they contribute to the more pronounced contraction at lower temperatures. While XRD measurements point to the formation of Ni{sub 3}Cr, TEM-EDS measurements reveal a composition of (Ni,Co){sub 2}Cr. Stress relief heat treatment at higher temperatures (815 C) after annealing shows that the effect of contraction is reversible. It causes an increase in lattice parameter and the Ni-Cr domains formed at lower temperatures are dissolved by the influence of higher temperatures. The sample elongation caused by stress relief heat treatment therefore is more pronounced for samples annealed at lower temperatures. The combination of lattice parameter change and formation of Ni-Cr rich domains explains the sample behavior within the first 300 hours. The further, slowly proceeding contraction for longer annealing times refers to carbide transformation. Particles of TiC and Ti(N,C) slowly dissolve in a peritectic reaction. An extrapolation of the results shows that complete dissolution will be reached after 14,000,000 hours (= 1,600 years). Dissolution of these phases leads to sample contraction reaching values of about -4,0.10{sup -4} after 10,000 hours. A contrary effect is caused by the concurrent formation of Cr{sub 23}C{sub 6}, which consumes the free C-atoms from carbide dissolution. Formation of this carbide type with 1.4% volume fraction is finished after 16,000,000 h (= 1,800 years). Within 10,000 h the phase formation leads to sample elongation of about +3,4.10{sup -4}. The combination of both effects almost cancels out and therefore only causes contraction of about -0,6.10{sup -4}, which is about 30% of the measured contraction. When the carbide transformation is complete, no further length change is expected. Although conditions are more complicated for alloy Inconel 718 due to the presence of additional phases (γ'' und δ-phase) the results can transferred in principal. The measured sample contraction is lower than for Waspaloy. Within the investigated temperature range the calculated phase diagram shows significant changes only for the phase fraction of γ{sup '} phase. As volume fraction of γ{sup '} precipitates is small (<10%) for Inconel 718, the compositional fluctuations caused by its dissolution are low. The measured length contraction at 450 C and 550 C therefore is only about -1,3.10{sup -4}. Temperatures of 650 C and above lead to formation of δ phase, which enhances the contraction to -2,6.10{sup -4} for standard heat treated samples. The reason for the lower impact of this effect for short-term heat treated sample could not fully be resolved in this work. A detailed investigation of the influence of γ'' phase an intense use of TEM techniques is necessary. Additionally, alloy Inconel 718 also shows low phase fractions of carbides and carbonitrides. Dissolution of (Ti,Nb)(C,N) has a bigger impact on contraction but is nearly stable while a slight decrease in (Nb,Ti)C content is measured. This causes a contraction of -0,6.10{sup -4}, which is way smaller than contraction caused by carbide dissolution in Waspaloy. This contributes to the reason, why overall contraction of Inconel 718 is less pronounced. The combination of several microstructural changes comprehensively explains the effect of contraction of Ni-based superalloys. The major part of the effect is caused by lattice parameter changes due to temperature dependent changes in stable phase fractions and compositions. The further minor contraction is referred to carbide transformation process.

  19. Urbanität nach exklusivem Rezept. Die Ausdeutung des Städtischen durch hochpreisige Immobilienprojekte in Berlin und Los Angeles

    Directory of Open Access Journals (Sweden)

    Henning Füller

    2013-07-01

    Full Text Available Innerstädtisches Wohnen steht zunehmend hoch im Kurs. Wahlweise als „Renaissance der Stadt“, Reurbanisierung oder Gentrifizierung thematisiert, ist das gegenwärtige Interesse von Investor_innen, Projektentwickler_innen und Käufer_innen an innerstädtischen Lagen prägnanter Ausdruck einer fortgesetzten Restrukturierung europäischer und US-amerikanischer Städte. Neben Prozessen der Inwertsetzung und Verdrängung umfasst diese Neuordnung auch die Ebene der Bedeutungen von Stadt und Urbanität. Insbesondere hochpreisige Neubauprojekte konkretisieren derzeit veränderte Vorstellungen bezüglich der Qualität der Stadt, ihrer Nutzer_innen und Nutzungsweisen. Der Beitrag zieht Projekte innerstädtischen Luxuswohnens in Berlin und Los Angeles heran, um dieser baulichen Konkretisierung von Diskursen um Stadt und Urbanität als Aspekt der gegenwärtigen „Renaissance der Stadt“ nachzugehen. In welcher Weise manifestieren sich Vorstellungen des erstrebenswerten städtischen Lebens in aktuellen Projekten hochpreisigen innerstädtischen Wohnungsbaus und welche Implikationen hat dies für die Gestalt der Stadt?

  20. Relationship between internal dosimetry and DNA double strand breaks in lymphocytes after radionuclide therapy; Zusammenhang zwischen physikalischer Dosimetrie und DNA Doppelstrangbruechen in Lymphozyten nach Radionuklidtherapie

    Energy Technology Data Exchange (ETDEWEB)

    Eberlein, Uta

    2015-09-30

    In radionuclide therapy radiopharmaceuticals are administered mostly systemically. Primarily, beta-emitters are used because of their short range in tissue. As a result the radiopharmaceutical distributes within the human body and accumulates in organs and target structures. Thus, the body is irradiated internally, in contrast to external irradiation in radiotherapy. The pattern of the activity distribution within the human body is determined by the physical and chemical properties of the radiopharmaceutical. Furthermore, the amount of activity and its accumulation in organs or tissues is essential for the calculation of the absorbed dose which defines the energy deposited in the body by ionizing radiation. During internal or external irradiation, patients are exposed to ionizing radiation which does not only destroy the malignant cells but also damages healthy tissue and cells. This is mainly caused by direct and indirect interaction of the radiation with the DNA which damages the DNA structure. Most frequently, there are single strand breaks and base damages. DNA double strand breaks (DSBs) are rare; nevertheless, they are the most critical lesions for cells as repairing the damage is difficult. Unrepaired or misrepaired DNA could cause mutations, chromosomal aberrations or lead to cell death. The formation of a DNA DSB in nuclear chromatin results in the rapid phosphorylation of the histone H2 variant H2AX, then called gamma-H2AX. Furthermore, DSBs also recruit the damage sensor 53BP1 to the chromatin surrounding the DSBs, which leads to 53BP1 and gamma-H2AX co-localization in the chromatin surrounding a DSB. By immunofluorescence staining with gamma-H2AX and 53BP1 antibodies those biomarkers can be addressed by microscopically visible DNA damage protein foci, this is also known as the DNA damage focus assay. With progression of DSB repair, gamma-H2AX and 53BP1 foci disappear. It is assumed that one focus corresponds to one DSB. Therefore, the number of foci per cell can be used as a quantitative biomarker for DNA double strand breaks and hence for radiation exposure and radiation effects. Most studies dealing with the DNA damage focus assay performed in the last years were looking only on the effect of external irradiation after external radiation therapy or after diagnostic radiology procedures, but only few with the effects after administration of radiopharmaceuticals. Therefore, the aims of this thesis were: 1. To develop a method to generate an in-vitro calibration curve for the DSB focus assay after internal irradiation with beta-emitting radionuclides by creating a low dose and low dose-rate blood irradiation situation in-vitro, at dose-rates that are similar to the ones that have been observed in nuclear medicine patients. 2. To determine the absorbed dose and the number of radiation-induced foci in lymphocytes by sampling blood from patients after radiopeptide therapy with Lu-177 and radioiodine therapy with I-131. 3. To describe comprehensively the temporal and dose-dependent behavior of the DNA damage focus assay in radiation treatment-naive patients after their first radionuclide therapy using the results of the in-vitro calibration. For the in-vitro calibration with I-131 and Lu-177 blood samples For the in-vitro calibration with I-131 and Lu-177 blood samples were drawn from volunteers. Different activity concentrations were added to the samples for achieving absorbed doses up to 100mGy. As a result it was shown that the number of radiation-induced foci were linearly dependent of the absorbed dose. This is the same result that has been shown after external irradiation. The patient studies addressed the relationship between the absorbed dose to the blood and the number and temporal behavior of radiation-induced DNA double strand breaks in peripheral blood samples under radiopeptide therapy and under radioiodine therapy. The average number of radiation-induced foci showed a linear dose-response relationship within the first hours after administration of the radiopharmaceutical. The slope of the in-vitro calibration curve was in good agreement with the slopes of the linear functions fitted to the in-vivo data for Lu-177 and I-131. Later time points were characterized by a diminishing number of radiation-induced foci which was in accordance with the progression of DNA repair and the declining dose rates. Most patients treated with I-131 exceeded 20mGy in the first hour and in these patients the onset of a fast repair component was observed. With the experimental results and model calculations presented in this work, for the first time a dose-response relationship and a description of the time course of the in-vitro and in-vivo damage response after internal irradiation of beta-emitters could be established.

  1. The modern Saamish reindeer husbandry in Sweden after the reactor accident of Chernobyl. Die moderne samische Rentierwirtschaft Schwedens nach dem Reaktorunfall von Tschernobyl; Eine humangeographische Struktur- und Problemanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Wolf, J

    1992-01-01

    Large parts of the reindeer herding area in Sweden were contaminated with radioactive caesium from the Chernobyl fallout deposited mainly between 62 and 66 n.lat. by heavy rain-and snowfalls between April 28-30, the fjell and boreal forest regions of north-western Jaemtland and south-western Vaesterbotten being the home of 500 reindeer Saamis, organized in 19 Saamebys, and being the winter- and summer reindeer grazing areas for about 100000 reindeer worst contaminated, with a maximum soil contamination of 60000 Bq/m[sup 2] Cs137 along a line Gaevle-Gaeddede. The socio-economic effects and consequences of Chernobyl have on the hand changed the daily and yearly work routine patterns by applying early slaughter and feeding programs. On the other hand it has shown the vulnerability of reindeer husbandry in particular and of Saami culture and livelihood in general. It has also pointed out the influence of the state compensation payments have helped the mostly hit Saamebys to survive economically and the Saami herders to preserve their ethic identity and specific way of life. The measure of introducing a strict radioactivity limit should be fixed internationally. In reindeer meat where the average annual consumption is as low as 200 g per person a limit as low as 300 pr 1500 Bq/kg is in fact ineffective in reducing cancer risks but it has proved disastrous for the reindeer meat market.

  2. The situation of nuclear rower after Fukushima. Public perception and political decisions; Die Situation der Kernenergie nach Fukushima. Wahrnehmung der Oeffentlichkeit und politische Entscheide

    Energy Technology Data Exchange (ETDEWEB)

    Gallego Carrera, Diana [Stuttgart Univ. (Germany). Zentrum fuer Interdisziplinaere Risiko- und Innovationsforschung; Hampel, Juergen [Stuttgart Univ. (Germany). Abt. fuer Technik- und Umweltsoziologie

    2013-03-15

    When nuclear power was introduced for electricity production in the mid-1950s, the access to nearly unlimited energy reserves it promised was expected to make the scarcity of energy supply a problem of the past. In the light of such expectations, the first nuclear reactors for electricity generation were built in Germany in the 1960s and in Switzerland in the late 1960s. Only a few years later, as early as in the 1970s, nuclear power developed into one of the present technologies discussed most controversially. While nuclear proponents considered the risks associated with the use of nuclear power low, nuclear opponents insisted mainly on debating the extent to which the risks of nuclear power were acceptable even if the probability of occurrence was low. History shows that there is no straight path in the development of nuclear power. While France made nuclear power the backbone of electricity production, other countries were much more reluctant to use nuclear power. After quite dramatic discussions in the 1970s and 1980s nuclear power seemed to develop into an unpopular but necessary evil to be accepted temporarily - whatever the definition of temporarily may be - until alternative sources of energy would replace it. Also in the social sciences, attention from the 1990s on concentrated on other topics, moving nuclear power into the background of interest. At present, the future of nuclear power looks rather bleak, at least in Germany and in Switzerland. The probability of change in the near future is discussed in this article. Attitudes towards nuclear power are analyzed first. A number of opinion polls, some of them permitting international comparison, allow public attitudes towards nuclear power in Europe, Germany, and Switzerland to be assessed. A next step deals with the cognitive background to attitudes, looking at risks and risk perception from a scientific perspective of risk studies. Another point considered is the identity of societally visible players who back nuclear power, and that of the players in society who act against this source of energy. (orig.)

  3. Late results after intertrochanteric varus angulation in aseptic femoral head necrosis in adults. Spaetergebnisse nach intertrochanterer Varisierungsosteotomie bei der aseptischen Hueftkopfnekrose Erwachsener

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, E.; Ahrendt, J.; Niethard, F.U.; Blaesius, K. (Heidelberg Univ. (Germany, F.R.). Orthopaedische Klinik und Poliklinik)

    1989-04-01

    25 patients suffering from femoral head necrosis in 30 hip joints were radiologically studied for an average of 11.6 years following intertrochanteric varus angulation osteotomy. Preoperatively only stages 2 and 3 according to Meyers were seen. The follow-up results could be distributed into 4 groups. At best the osteonecrosis was reconstructed within 6 to 9 years while the trabeculae started to become rearranged within 2 to 4 years. At worst, rapid destruction in absence of bony reaction was observed. The ability of the bone outside the osteonecrosis to react to changed circumstances following angulation osteotomy correlates with long-term results. This may indicate a general osteopathy even outside the necrotic area. (orig.).

  4. Striated nephrogram as an incidental finding in MRI examination of children; Streifiges Nephrogramm als Zufallsbefund nach Kontrastmittelgabe bei Kindern in der MRT

    Energy Technology Data Exchange (ETDEWEB)

    Strocka, S.; Sorge, I.; Ritter, L.; Hirsch, F.W. [Leipzig Univ. (Germany). Dept. of Pediatric Radiology

    2016-01-15

    A highly striated contrast pattern of the kidneys occasionally appears in abdominal MRI examinations of children following the administration of gadolinium. As this phenomenon is well known but has not yet been explicitly described in literature, we investigated how frequently and in which clinical context this occurred. 855 abdominal MRI examinations with contrast media of 362 children between 2006 and 2014 were analysed retrospectively. A striated renal parenchyma was found in a total of nine children and eleven examinations (1.3 % of examinations) and did only occur at a field strength of 3 Tesla. Of these children, seven had previously had tumors and chemotherapy. In two children there was no evidence of a previously serious condition with medications or a kidney disease. All of them had a normal renal function. A noticeably striated nephrogram in the later phase of an MRI examination following administration of gadolinium may appear as an incidental finding in examinations at 3 Tesla without pathological relevance.

  5. Quantum fishes. The string theory and the search for the world formula; Quantenfische. Die Stringtheorie und die Suche nach der Weltformel

    Energy Technology Data Exchange (ETDEWEB)

    Luest, Dieter

    2014-11-01

    Can all physical phenomena from the smallest particles to the universe be uniquely described? The hottest candidate for such a world formula is the string theory. The renowned physicist Dieter Luest explains by means of a story of ''quantum fishes'', intelligent fishes in a pond, the foundations and essential principles of the string theory.

  6. Changes in equipment and image quality. Impact of one year Austrian breast cancer early detection programme; Aenderungen in der Geraetelandschaft und Bildqualitaet. Auswirkungen nach einem Jahr Oesterreichischem Brustkrebsfrueherkennungsprogramm

    Energy Technology Data Exchange (ETDEWEB)

    Menhart, S.; Osanna-Elliott, A.; Semturs, F.; Schloegl, C.; Wildner, S.; Zwettler, G. [AGES, Wien (Austria). Referenzzentrum fuer technische Qualitaetssicherung im Brustkrebsfrueherkennungsprogramm

    2015-07-01

    The nationwide Austrian Breast Cancer Early Detection Programme (''BKFP'') started in January 2014. The Austrian Agency for Health and Food Safety Ltd. was entrusted with running the reference center for technical quality control (''RefZQS'') on April 1, 2014. The quality of the radiologists' equipment is evaluated against the standards described in the EUREF-Oeprotocol, which is based on the European guidelines for quality assurance in breast cancer screening and diagnosis (EPQC V4, 2006) and has been optimized for Austrian requirements. In its first year of operation the RefZQS has controlled the entire equipment (mammography, periphery and ultrasound system) of all participating radiologists. A significant number of systems had to be adjusted to meet the EUREF-Oecriteria. Some of the systems could not be adjusted accordingly, and had to be replaced. In the wake of the start of the screening programme, several sites switched from CR to more modern DR systems, yielding a significant benefit by reduction of radiation burden. The most important data after one year of RefZQS, especially according to adjustments and replacements, are presented.

  7. Radioactivity concentrations in Bavarian surface water after the Chernobyl reactor accident. Radioaktive Belastungen des Wassers in Bayern nach dem Reaktorunfall in Tschernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Amann, W; Friedmann, L; Lux, D

    1986-01-01

    The special investigation programme for monitoring radioactive immissions, which was primarily concerned with drinking water, initially led to the discovery of high rates of precipitate pollution by I-131, I-132, Cs-134, Cs-137 and Te-132. Since initial investigations had revealed no increases in total alpha and tritium values, gamma-spectrometric determinations were effected exclusively for single nuclides. Later on, a considerable accumulation of the nuclides Cs-134, Cs-137 and Ru-103 was discoverd in the sediments of surface bodies of water and in sewage sludges. The effects of the reactor accident on surface water are still being monitored in a long-term metering programme. (DG).

  8. Nuclear atlas. After Chernobyl: Nuclear energy between fear and hope. Figures - facts - background information. Der Atomatlas. Nach Tschernobyl: Kernenergie zwischen Angst und Hoffnung. Zahlen - Fakten - Hintergruende

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, M; Schmidt, A

    1986-01-01

    Chernobyl has become the catchword that reveals the profound difference of opinions among experts and the population on the issue of nuclear energy. In the many discussions in the public media and elsewhere after the Chernobyl accident, technical terms and scientific terminology and analytic data have been used that induced a feeling of helplessness in the general public, simply because people are not familiar with this terminology and subject. What does 'radioactivity' really mean. What damage to health is done by ionizing radiation. Who finds his way through the muddle of measuring units for radiation, such as rem, Becquerel, or Curie. How does a nuclear power plant work. What kind of reactors are operating in Europe. How safe are they. Where are they. What is a reprocessing plant. These are only a few of the many questions the book answers. The information is intended for the general reader, and supplemented by numerous illustrations, maps, tables and graphs.

  9. Higher efficiency, lower bonuses. Financial incentives for power from biomass according to EEG 2012; Mehr Effizienz, weniger Boni. Die Foerderung von Strom aus Biomasse nach dem EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Dominik [Ecologic Institute, Berlin (Germany)

    2012-07-01

    The German parliament passed a total of eight new laws for the intended energy turnaround. Apart from changes in atomic law, the focus was on a complete amendment of the Renewables Act (EEG). The contribution outlines the new regulations for power generation from biomass from 2012. It indicates the changes from former regulations and describes the structural changes required for sustainable power supply from biomass, among others.

  10. Heat grids today and after the German Renewable Energies Act (EEG). A business segment for the agriculture?; Waermenetze heute und nach dem EEG. Ein Betriebszweig fuer die Landwirtschaft?

    Energy Technology Data Exchange (ETDEWEB)

    Clemens, Dietrich; Billerbeck, Hagen [Treurat und Partner Unternehmensberatungsgesellschaft mbH, Lueneburg (Germany). Abt. ' ' Climate and Energy' '

    2016-08-01

    The development of a centralised and sustainable heat supply through the construction of heat grids offers consumers numerous advantages compared to a decentralised energy supply of residential and commercial properties. Where the migration to centralised heat supply relegates fossil fuels through the long-term incorporation of sustainable renewable energy sources, the projects make an important contribution towards meeting the government's climate protection goals. Heat generation and heat sales from renewable energy sources should be ensured in the long term. In the countryside, biogas plant operators are frequently the initiators of heat grid investments, or they take on the role of supplier for the provision of low-cost CHP heat from cogeneration units. In view of the limited remuneration period under the terms of the German Renewable Energy Act, the clock is ticking for the establishment of a centralised heat supply. This paper presents the advantages and disadvantages of a centralised, sustainable heat supply and additionally considers the flexibi/isation of biogas plants in view of the construction of the heat grid and the associated infrastructure. A focus is placed on the security of supply for customers after the discontinuation of remuneration under the German Renewable Energy Act and on how a competitive heat price from alternative energy sources can continue to be ensured.

  11. Außergerichtliche Vollstreckung aus der Hypothek und Quasi-Datio in Solutum nach russischem Recht – Teil 2 / Tim Lassen

    Index Scriptorium Estoniae

    Lassen, Tim

    2014-01-01

    Hüpoteeklaenudega seotud vaidlustest Venemaal. Hüpoteekidega seotud õigusaktide rakendamise probleemidest ja vastavatest vahekohtu lahenditest. Järg. Algus Wirtschaft und Recht in Osteuropa 20014, nr. 5, lk. 136-140

  12. Local recurrences after conservative surgery and irradiation for breast cancer: Diagnosis with mammography and ultrasound. Mammographie und Sonographie in der Rezidivdiagnostik nach brusterhaltender Therapie des Mammakarzinoms

    Energy Technology Data Exchange (ETDEWEB)

    Buchberger, W; Hamberger, L; Schoen, G [Innsbruck Univ. (Austria). Universitaetsklinik fuer Radiodiagnostik; Steixner, G; Fritsch, E [Innsbruck Univ. (Austria). Universitaetsklinik fuer Strahlentherapie

    1991-06-01

    89 patients, who underwent conservative surgery for breast cancer were followed up with mammography and real-time sonography. 78 patients underwent postoperative irradiation. Depending on the time interval between irradiation and examination various alterations in mammographic and sonographic patterns were evident. Of 14 biospy-confirmed local recurrences, 11 were diagnosed by mammography and 12 by sonography. Combined use of mammography and sonography should therefore lead to better results in the diagnosis of local recurrences and to a reduction of unnecessary biopsies. (orig./GDG).

  13. Following the radiation accident in Fukushima. Consequences for information management; Nach dem Strahlenunfall in Fukushima. Ein Beitrag zur Aufarbeitung der 'Lessons Learnt'

    Energy Technology Data Exchange (ETDEWEB)

    Meineke, Viktor [Universitaet der Bundeswehr, Muenchen (Germany). Inst. fuer Radiobiologie

    2012-07-01

    The differing perceptions of risk in Japan and Germany, the changing psychosocial factors since the Chernobyl event, and the problem of the lacking basic knowledge concerning radiation effects at the general population as well as partially in medical circles are discussed and conclusions are made regarding the information management and the medical management of radiation accidents. (orig.)

  14. Local energy supply under national and European law. With special regard to municipal policy opportunities. Oertliche Energieversorgung nach nationalem und europaeischem Recht. Unter besonderer Beruecksichtigung kommunaler Gestaltungsmoeglichkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Britz, G.

    1994-01-01

    Conceivably, the erection of a single European energy market for electricity and natural gas as specified in the EC draft guidelines may change the conditions of local energy supply. This thesis therefore investigates which instruments are at the disposal of municipal governments for the realization of energy-political concepts of their own: Rights of way and granting of franchises, establishment of and transfer of tasks to municipal utilities, common carvier duties, and free choice of suppliers by distributors. The handling of franchise payments and treatment of municipal interconnected networks are of considerable importance for the financial situation of communities. The first section deals with the legal issues of local energy supply with regard to national law. The second part deals with the same questions with regard to community law. Furthermore it is considered what would be the consequences of the realization of the two guidelines concerning the single energy market. In the final section the results are compared and the significance of community law for local energy supply is assessed. (orig./HP)

  15. The climate-problem. Evaluation after the Paris-agreement and the Marrakesh-conference; Das Klimaproblem. Bewertung nach dem Paris-Abkommen und der Marrakesch-Konferenz

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2017-05-15

    The Paris-Climate-Agreement came into effect on November 4th 2016. Still, the contradiction in this agreement - ambitious goals and (presumably) inadequate commitments - has persisted. Also in the follow-up conference in Marrakesh, this discrepancy remained unresolved. 2017 the countries will meet again. However, since Donald Trump became president-elect of the United States of America, uncertainty about how the largest economy in the world will act in the future has intensified. This amplifies the pressure to clarify the true level of human influence on the climate in a scientifically consistent manner, as a basis for more reliable decisions. This paper tries to contribute to that effort.

  16. Magnet discolation - An increasing and serious complication following MRI in patients with chochlear implants; Magnetdiskolation - eine zunehmende und folgenreiche Komplikation nach MRT bei Patienten mit Cochlea Implantat

    Energy Technology Data Exchange (ETDEWEB)

    Hassepass, F.; Staubenau, V.; Arndt, S.; Beck, R.; Grauvogel, T.; Aschendorff, A. [Univ. Medical Center Freiburg (Germany). Dept. of Otorhinolaryngology-Head and Neck Surgery; Bulla, S. [Univ. Medical Center Freiburg (Germany). Dept. of Diagnostic Radiology

    2014-07-15

    Cochlear implantation (CI) represents the gold standard in the treatment of children born deaf and postlingually deafened adults. Initial magnetic resonance imaging (MRI) was contraindicated in CI users. Meanwhile, there are specific recommendations concerning MRI compatibility depending on the type of CI system and the device manufacturer. Some CI systems are even approved for MRI with the internal magnet left in place. The aim of this study was to analyze all magnet revision surgeries in CI patients at one CI center and the relationship to MRI scans over time. Between 2000 and 2013, a total of 2027 CIs were implanted. The number of magnet dislocation (MD) surgeries and their causes was assessed retrospectively. In total 12 cases of MD resulting from an MRI scan (0.59 %) were observed, accounting for 52.2 % of all magnetic revision surgeries. As per the labeling, it was considered safe to leave the internal magnet in place during MRI while following specific manufacturer recommendations: MRI intensity of 1.5 Tesla (T) and compression head bandage during examination. A compression head bandage in a 1.5 T MRI unit does not safely prevent MD and the related serious complications in CI recipients. We recommend a Stenvers view radiograph after MRI with the internal magnet in place for early identification of MD, at least in the case of pain during or after MRI examination. MRI in CI patients should be indicated with restraint and patients should be explicitly informed about the possible risks. Recommendations regarding MRI compatibility and the handling of CI patients issued with MRI for the most common CI systems are summarized.

  17. International demands for retrofitting, trends in the nuclear industry, safety margins, concepts and options for retrofit; Nachfrage nach Nachruestungen international; industrielle Trends; Rolle von Sicherheitsmargen, Nachruestkonzepte und -moeglichkeiten

    Energy Technology Data Exchange (ETDEWEB)

    Janke, Rolf; Stoll, Uwe; Grasnick, Claudius [AREVA GmbH, Erlangen (Germany). E and P, P-G

    2016-02-15

    The serious accidents at Fukushima in 2011 pointed out the missing implementation of existing international safety standards for nuclear power plants as also new aspects for nuclear safety. The main safety aspects in the aftermath of Fukushima are: robustness against internal and external impacts; sufficient safety margins; prolonged periods for safety measures; inherent and passive systems and mechanisms; enhanced independent operation of the plant in case of external failures; independent long-term supply with AC; accident management procedures; enhanced retention of radionuclides. Technologies for retrofit are available and are under implementation with respect to the demands and options in the countries using nuclear power.

  18. Waste treatment by the CCP/EuRec {sup trademark} process; Abfallbehandlung nach dem CCP/EuRec {sup trademark} -Restabfallbehandlungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Lippmann, A. [CCP GmbH, Waste Management, Merkers (Germany)

    2002-07-01

    The CCP/EuRec {sup trademark} process involves either an aerobic (composting) or an anaerobic (fermentation) biological treatment stage, or a combination of both. [German] Bei dem CCP/EuRec {sup trademark} -Restabfallbehandlungsverfahren handelt es sich um ein leistungsfaehiges System zur biologischen Behandlung von Restabfaellen. Die biologische Behandlungsstufe kann wahlweise aerob (Rotte) oder anaerob (Vergaerung) erfolgen. Eine Kombination zwischen beiden Varianten ist ebenfalls moeglich. (orig.)

  19. MRI after patellar dislocation. Assessment of risk factors and injury to the joint; MRT nach Patellaluxation. Quantifizierung der Risikofaktoren und Beschreibung der Folgeschaeden

    Energy Technology Data Exchange (ETDEWEB)

    Diederichs, G. [Charite Universitaetsmedizin, Berlin (Germany). Radiologie; Scheffler, S. [Charite Universitaetsmedizin, Berlin (Germany). Zentrum fuer Muskuloskeletale Chirurgie; Chirurgisch Orthopaedischer PraxisVerbund, Berlin (Germany)

    2013-07-15

    Patellar dislocation is the lateral displacement of the patella from the femoral trochlea. Affected individuals typically have underlying anatomic risk factors of variable magnitude, which, in conjunction with leg rotation, cause the event. Magnetic resonance imaging (MRI) permits straightforward diagnosis of the typical features of recent patellar dislocation: contusion edema of the inferomedial patella and the lateral femoral condyle as well as rupture of the medial patellofemoral ligament. In case of concomitant osteochondral injury, early surgical refixation may be indicated, depending on the size. After a first dislocation, which can damage the capsuloligamentous stabilizers, subjects may sustain further dislocations or even develop chronic patellofemoral instability, depending on the presence and severity of anatomic variants. A wide range of conservative and surgical treatments are available. While a first patellar dislocation is often treated conservatively, surgical strategies after a second dislocation depend on the pattern of injury and the severity of underlying anatomic risk factors. The most relevant predisposing variants are trochlear dysplasia, patella alta, and an abnormal tibial tubercle to trochlear groove distance (TT-TG). The radiologist's report should give a quantitative estimate of both the injuries resulting from dislocation and the underlying anatomic risk factors. An accurate characterization of the individual pathomechanism is crucial for tailoring treatment. (orig.)

  20. Japan's energy sector beyond Fukushima. What direction for a sustainable energy future?; Japans Energiesektor nach Fukushima. Welche nachhaltige Energiezukunft ist moeglich?

    Energy Technology Data Exchange (ETDEWEB)

    Feldhoff, Thomas [Frankfurt Univ., Frankfurt am Main (Germany). Inst. fuer Humangeographie (IHG) und Interdisziplinaeres Zentrum fuer Ostasienstudien (IZO)

    2013-03-15

    The 11 March 2011 Fukushima nuclear power plant disaster will create long-term challenges for Japans energy security. Energy shortage is a major threat because all facets of the archipelago's economy and society are dependent upon reliable energy supply. Within this context and based on a historical institutionalist approach, this paper reflects on the long-term implications of the disaster for Japan's post-Fukushima energy policies. It argues that institutional change is incremental and path dependent for four major reasons: the massive costs of a major move to alternative energy sources; the rising importance of emission reduction and climate change mitigation policies; vested interests in the status quo of a centralised large-scale energy supply system; and the massive increase in resource nationalism in East Asia as a result of continuing geopolitical tensions. However, promoting energy efficiency, encouraging energy-saving behaviour and focusing on decentralized renewable energy development could help to reduce Japan's energy vulnerability.

  1. X-ray-induced DNA double-strand breaks after angiographic examinations of different anatomic regions; Strahleninduzierte DNA-Doppelstrangbrueche nach Angiografien verschiedener Koerperregionen

    Energy Technology Data Exchange (ETDEWEB)

    Kuefner, M.A.; Schwab, S.A.; Azoulay, S.; Heckmann, M.; Heinrich, M.C.; Uder, M. [Universitaetsklinikum Erlangen (Germany). Radiologisches Inst.; Grudzenski, S.; Lobrich, M. [Technische Univ. Darmstadt (Germany). Strahlenbiologie und DNA-Reparatur

    2009-04-15

    Purpose: The aim of this study was to investigate DNA double-strand breaks (DSBs) in blood lymphocytes as markers of the biological radiation effects in angiography patients. Materials and Methods: The method is based on the phosphorylation of the histone variant H 2AX ({gamma}-H2AX) after formation of DSBs. Blood samples were collected before and up to 24 hours after exposure of 31 patients undergoing angiographies of different body regions. Blood lymphocytes were isolated, fixed, and stained with a specific {gamma}-H2AX antibody. Distinct foci representing DSBs were enumerated using fluorescence microscopy. Additional in-vitro experiments (10 - 100 mGy) were performed for evaluation of DBS repair. Results: 15 minutes after the end of fluoroscopy values between 0.01 and 1.50 DSBs per cell were obtained. The DNA damage level normalized to the dose area product was 0.099 (cardiac angiographies), 0.053 (abdominal angiographies), 0.023 (pelvic/leg angiographies) and 0.004 excess foci/cell/mGym{sup 2} (cerebrovascular angiographies). A linear correlation was found between {gamma}-H2AX foci levels and the dose area product (abdomen: R2 = 0.96; pelvis/legs: R2 = 0.71). In-vivo on average 46 % of DSBs disappeared within 1 hour and 70 % within 2.5 hours. Conclusion: {gamma}-H2AX immunofluorescence microscopy is a sensitive and reliable method for the determination of X-ray-induced DSBs during angiography. The DNA damage level depends on the dose, the exposed anatomic region, and the duration/fractionation of the X-ray exposure. (orig.)

  2. First MRI results of the therapeutic course of avascular femoral head necrosis after femoral core decompression; Erste kernspintomographische Ergebnisse des Therapieverlaufs bei avaskulaerer Femurkopfnekrose nach Femurkerndekompression

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, H.F. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany); Schedel, H. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany); Schneller, A. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany); Eisenschenk, A. [Universitaetsklinikum Benjamin Franklin, Berlin (Germany). Orthopaedische Klinik und Poliklinik; Wicht, L. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany); Siekmann, R. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany); Felix, R. [Strahlenklinik und Poliklinik, Virchow Klinikum, Humboldt Univ, Berlin (Germany)

    1997-03-01

    The vascular femoral head necrosis is a serious illness, especially when appearing in patients aged 30 to 50 years. Many etiologic factors cause a femoral head necrosis such as, for example, high-dose steroids, abuse of alcohol, defect of bone marrow and trauma of the hip. Often the X-ray photograph leads to the diagnosis in the second stage (ARCO 1992) or in the third stage, when the femoral head has begun to collapse. The stage IIc and III shows an evident enhancement in contrast media in MRI. Contrast enhancement is demonstrated by STIR, FATSAT, T1-weighted and dynamic screening sequence. The characteristics of the contrast media enhancement argue for an active concomitant process of destruction and regeneration. This stage has the best chances for a drug or a surgical therapy. The evaluation of the signal intensity by the dynamic screening sequence is considered as an objective contribution for the staging of the femoral head necrosis. This enables one to differentiate between the curable stage IIc and the stage III, showing the beginning of breakdown of the femoral head. (orig.) [Deutsch] Die avaskulaere Femurkopfnekrose (AVN) ist eine schwerwiegende Erkrankung, die insbesondere bei Patienten im Alter zwischen 30 und 50 Jahren auftritt. Ein Vielzahl von aetiologischen Faktoren wie Einnahme von hohen Dosen Steroiden ueber mehrere Monate, Alkoholmissbrauch, Knochenmarkschaeden und Huefttraumata spielen unabhaengig voneinander eine Rolle. Die Diagnose erfolgt ueblicherweise im zweiten Stadium (ARCO 1992) auf dem Roentgenbild oder im Stadium III, wenn der Femurkopf begonnen hat mechanisch nachzugeben. Eine deutliche kernspintomographisch nachweisbare Kontrastmittelaufnahme zeigen die Stadien ARCO IIc und III, wie die Werte der Dynamic Screening Sequence, der STIR-, der FATSAT und der T{sub 1}-gewichteten Sequenzen belegen. Das Kontrastmittelaufnahmeverhalten spricht fuer einen gleichzeitig aktiven destruierenden und regenerativen Prozess, der fuer einen operativen und medikamentoesen Eingriff das guenstigste Stadium mit den besten Heilungschancen ist. Die Auswertung der Signalintensitaetswerte mit der `Dynamic Screening Sequence` ermoeglicht die Einteilung der Nekrose und die Differenzierung in das noch therapiebare Stadium ARCO IIc, bei dem der Femurkopf noch nicht wie bei ARCO III entrundet ist. (orig.)

  3. Suche nach dem Higgs-Boson in hadronischen Endzuständen mit fehlender Energie am L3-Experiment bei LEP

    CERN Document Server

    Zöller, Marc Henning

    2005-01-01

    This thesis presents searches for the Higgs boson, which is predicted by the Standard Model of Particle Physics and its extensions in order to endow fermions and bosons with their observed masses. While the Standard Model predicts only one Higgs boson »H«, the Minimal Supersymmetric Extension contains five Higgs bosons. This analysis refers to the light neutral »h«, which has nearly the same properties as the Standard Model Higgs boson. The analyses are based on data taken by the L3 experiment at the Large Electron Positron Collider (LEP) near Geneva during the years 1998 until 2000, which corresponds to an integrated luminosity of 629.7 pb−1 and which were collected in a center-of-mass energy range from 189 GeV to 209 GeV. The Higgs boson searches presented here analyse the data with regard to hadronic events with missing energy, since the visible energy is reduced compared to the total energy given by the LEP collider. According to theoretical prediction these final states can be produced via the Higg...

  4. Reduction of the interlocking potential of sump sieves by corrosion products as consequence of loss-of-coolant accidents; Verminderung des Verblockungspotenzials von Sumpfansaugsieben durch Korrosionsprodukte nach Kuehlmittelverluststoerfaellen

    Energy Technology Data Exchange (ETDEWEB)

    Hoffmann, Wolfgang; Kryk, Holger [Helmholtz-Zentrum Dresden-Rossendorf, Dresden (Germany). Inst. fuer Fluiddynamik

    2012-11-01

    In German nuclear power plants thermal insulation fragmentation as a consequence of loss-of-coolant accidents have not been identified, but recently significant pressure increase in the sump sieves due to corrosion products have been observed. The corrosion products are released from hot-galvanized steel grids by steam jet fragmentation. It was shown that critical deposition of corrosion products can occur in the long-term process of the accident. The hazard of sieve blocking could be reduced by zinc containing chemicals or an increase of the pH value (to about 6.7). The possibility of disadvantageous consequences of resulting chemical reactions has to be investigated in the future.

  5. Medien – Generationen – Wissen. Überlegungen zur medienpädagogischen Forschung – dargestellt am Beispiel der Frage nach dem Weltwissen globaler Mediengenerationen

    Directory of Open Access Journals (Sweden)

    Theo Hug

    2017-07-01

    Full Text Available Mit den aktuellen gesellschaftlichen, technologischen und politischen Entwicklungen haben sich neue Fragen und Aufgabenbereiche für die Medienpädagogik ergeben. Diese werden im vorliegenden Beitrag skizziert, wobei in Abgrenzung von traditionellen Auffassungen für ein weiteres Verständnis von Medienpädagogik argumentiert wird. Die Erweiterung des thematischen Horizonts wird anhand einer Pilotstudie zur Frage des Weltwissens von Mediengenerationen exemplarisch verdeutlicht. Abschließend werden einige Überlegungen zur Medienkompetenz, der Problematik diesbezüglicher Verkürzungen und deren Stellenwert im Lichte des „medial turn“ zur Diskussion gestellt.

  6. Search after new agents for hyperpolarization-activated and cyclic nucleotide-gated ion channels; Suche nach neuen Wirkstoffen fuer Hyperpolarisationsaktivierte und zyklisch Nukleotid-gesteuerte Ionenkanaele

    Energy Technology Data Exchange (ETDEWEB)

    Struenker, T.

    2005-12-01

    Rhythmic activity of single cells or cellular networks is a common feature of most organisms. Cellular rhythms govern the beating of the heart, cycles of sleep and wakefulness, breathing, and the release of hormones. The endogenous rhythmic activity of many neurons and cardiac relies on a complex interplay between several distinct ion channels. In particular, one type of ion channel plays a prominent role in the control of rhythmic electrical activity because it determines the frequency of the oscillations. The activity of the channels is thus setting the ''pace'' of the activity; therefore, these channels are often referred to as ''pacemaker'' channels. Despite their obvious physiological importance it hasn't been until a few years ago that the genes encoding pacemaker channels have been identified. Because both hyperpolarization and cyclic nucleotides are key elements that control their activity, pacemaker channels have now been designated hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. From a scientific as well as medical point of view, HCN channels are interesting drug targets. Only a few substances are known that specifically affect HCN channels. In the present study, a microtiter plate-based high throughput screening assay for HCN1 and HCN4 channels was developed. With this assay, known drugs for HCN channels were characterized. Subsequently, venoms of snails, spiders, scorpions, and snakes were screened for toxins affecting HCN channel activity. A few venoms were identified that possibly contain drugs that act on HCN channels. (orig.)

  7. Alle Wege führen nach Rom: Trifft dies auch für die Veränderungsmessung zu?

    DEFF Research Database (Denmark)

    Boecker, Maren; Volz-Sidiropoulou, Eftychia; Nielsen, Tine

    Die Erfassung von Veränderungen mithilfe von Fragebögen spielt eine wichtige Rolle in der klinischen Praxis und Forschung. Ziel dieser Studie war es zu untersuchen, ob im Rahmen der Veränderungsmessung die verwendete Datenanalysemethode einen Einfluss auf die Studienergebnisse hat. Insbesondere w...

  8. Nephrogenic systemic fibrosis after application of gadolinium-based contrast agents - a status paper; Nephrogene systemische Fibrose nach Anwendung gadoliniumhaltiger Kontrastmittel - ein Statuspapier zum aktuellen Stand des Wissens

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, M.; Uder, M. [Erlangen-Nuernberg Univ., Erlangen (Germany). Inst. fuer Radiologie

    2007-06-15

    Recently the association of a rare disease named ''nephrogenic systemic fibrosis'' (NSF) with the administration of gadolinium-containing contrast media, especially gadodiamide (Omniscan, GE-Healthcare), was described. NSF is a scleroderma-like disease characterised by widespread tissue fibrosis. Until now, NSF cases were observed only in patients with kidney disease. Almost all patients were suffering from chronic renal insufficiency, 90 % of them required renal replacement therapy. The true incidence of the disease is unknown. First retrospective analyses of selected collectives of patients with end-stage renal disease showed 2 - 5 % cases of NSF after administration of Gadolinium-containing contrast agents with an odds ratio of 20 - 50 in comparison to non-exposed controls. NSF is a serious adverse reaction, which may result in severe disabilities and even death. Therefore all radiologists applying gadolinium-based contrast agents should be informed about this disease and the recent recommendations for its prevention. On the basis of the published data, Omniscan should not be used in patients with severe renal impairment (GFR < 30 ml/min/1.73 m{sup 2}) and those who have had or are undergoing liver transplantation. In neonates and infants up to 1 year of age, Omniscan should only be used after careful consideration. Also the other gadolinium-based contrast agents should be used in high-risk patients only after careful consideration using the lowest dose possible.

  9. Die Anwesenheit des Abwesenden. Nostalgie und das kulturelle Gedächtnis böhmisch-mährischer Landjuden vor und nach der Shoah

    Czech Academy of Sciences Publication Activity Database

    Koeltzsch, Ines

    2016-01-01

    Roč. 3, č. 2 (2016), s. 37-57 E-ISSN 2408-9192 Institutional support: RVO:67985921 Keywords : Jews * Bohemian Lands * memoirs Subject RIV: AB - History http://simon.vwi.ac.at/images/Documents/Articles/2016-2/2016-2_ART_Koeltzsch/ART_Koeltzsch01.pdf

  10. Iran, the bomb and the pursuit of security. Structured conflict analyses; Iran, die Bombe und das Streben nach Sicherheit. Strukturierte Konfliktanalysen

    Energy Technology Data Exchange (ETDEWEB)

    Bock, Andreas M. [Akkon-Hochschule fuer Humanwissenschaften, Berlin (Germany); Henneberg, Ingo (ed.) [Freiburg Univ. (Germany). Professur fuer Governance in Mehrebenensystemen

    2014-07-01

    This volume introduces readers to the structured conflict analysis as a tool of social science research and uses this instrument exemplarily to analyze systematically and on a broad basis the various conflicts that are associated with Iran both domestically and in foreign policy - beyond popular stereotypes such as the ''bomb''. The 13 contributions draw a complex picture of the conflicts with and in Iran and reflect the various aspects of these conflicts from different perspectives and at a high methodological and theoretical level. The nuclear program is examined, inter alia through the eyes of four major theories of International Relations. In addition, the analyses are concerned with the regional security dimension, the relationship USA-Iran, the role of national preferences, and the effect of national processes to the Iranian foreign policy.

  11. Climate to measure. Facility management for Universal Music at Berlin; Klima nach Mass. TGA-Planung fuer Universal Music in Berlin

    Energy Technology Data Exchange (ETDEWEB)

    McLead, E.A.

    2002-07-01

    Designing and constructing the technical facilities for a historical building like the 'Spreespeicher' in Berlin is a difficult but interesting task. The building is owned by Universal Music. Each department has its own office structure, and all offices and structures were integrated in a functional overall concept by the planners of Happold Ingenieure. [German] Klima, Lueftung und Elektroinstallation fuer ein historisches Gebaeude wie den Berliner Spreespeicher zu entwickeln, ist eine schwierige, aber reizvolle Aufgabe. Besonders, wenn der Nutzer Universal Music heisst: Jede Abteilung besitzt ihre eigene Buerostruktur, und alle mussten die TGA-Planer von Happold Ingenieure in ein funktionierendes Gesamtkonzept integrieren. (orig.)

  12. The German ''Energiewende''. Evaluation after the Paris-agreement; Die Deutsche Energiewende. Bewertung nach dem Klima-Abkommen von Paris

    Energy Technology Data Exchange (ETDEWEB)

    Roth, Eike

    2016-12-15

    The World-Climate-Summit 2016 in Paris agreed to exacerbated goals for climate protection. This paper will scrutinize whether Germany can comply with its Paris-obligations by continuing the ongoing German ''Energiewende''. The result is clear-cut: The German ''Energiewende'' is inadequate. Due to the cap-and-trade system of the EU the ''Energiewende'' can in no way contribute to climate protection.

  13. Updated action plan for the implementation of measures as a consequence of the Fukushima reactor accident; Fortgeschriebener Aktionsplan zur Umsetzung von Massnahmen nach dem Reaktorunfall in Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2014-01-15

    The action plan of the German government concerning the measures following the Fukushima reactor accident include the decision on the future of nuclear power in Germany, safety analyses, investigations and measures for nuclear power plants in a national frame, investigations in an international frame, planning for the implementation of CNS (Convention on nuclear safety) topics 1-3, i.e. measures to increase the robustness in German nuclear power plants, and the planning of implementation of further measures (CNS topics 4-6).

  14. Nachtraege zu den „Tertiaerschichten auf Java.” 1ter Nachtrag: Mollusken. Nach Sammlungen der Indischen Bergbeamten, Hunghuhn’s und Reinwardt’s

    NARCIS (Netherlands)

    Martin, K.

    1881-01-01

    Durch Vermittelung Verbeek’s erhielt ich eine grosse Reihe von Versteinerungen, welche von Bergbeamten Indiens (hauptsächlich von R. Everwijn und P. van Dijk) gesammelt waren und sich bis vor Kurzem, ohne näher untersucht zu sein, in Batavia befanden ¹). Diese Sammlung umfasste neben vielem

  15. Tanne plant - first results of soil treatment according to the anaerobic/aerobic method; Werk Tanne - Erste Ergebnisse der Bodenbehandlung nach dem Anaerob-Aerob-Verfahren

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, D.; Walter, U. [Umweltschutz Nord GmbH, Ganderkesee (Germany)

    1999-02-01

    Biological remediation of STV contaminated sites has been a major focus of the promotion activities of the Federal Research and Education Ministry (BMFB) for some years now. For this purpose the BMFB has drawn together diverse integrated research projects to bring a well-coordinated force of activities to bear on this problem in a manner unprecedented in Germany. Its declared aim in doing so is, firstly, to compile a guide on biological remediation and, secondly, to funnel the output of all ongoing German research in this field into the second phase of its research activities at the ''Tanne'' plant in Clausthal-Zellerfeld, which is dedicated to practice-oriented testing of methods for the biological remediation of STV contaminated sites. [German] Die biologische Sanierung von Standorten, welche mit STV kontaminiert sind, ist seit einigen Jahren eines der markanten Ziele der BMBF-Forschungsfoerderungen. Durch die bislang in der bundesweiten Forschung einmalige, Forschungsverbund uebergreifende, koordinierte Buendelung saemtlicher wissenschaftlicher Aktivitaeten ist es erklaertes Ziel, zum einen einen Leitfaden zur biologischen Sanierung herauszuarbeiten, zum anderen, die aktuellen, bundesweiten, wissenschaftlichen Erkenntnisse in die seit Mai 1998 am Standort 'Werk Tanne' in Clausthal-Zellerfeld laufende Phase 2 der BMBF-Forschungsaktivitaeten, naemlich die praxisorientierte Erprobung von Verfahren zur biologischen Sanierung von STV-belasteten Standorten, einzugreifen. (orig.)

  16. Legal issues relating to the feed-in of biogas under the Gas Network Access Ordinance; Rechtsfragen der Biogaseinspeisung nach der GasNZV

    Energy Technology Data Exchange (ETDEWEB)

    Stappert, Holger; Johannsen, Sven Leif Erik [Luther Rechtsanwaltsgesellschaft mbH, Duesseldorf (Germany)

    2012-07-01

    In the authors' view, the legislature has set itself ambitious goals in regulating the feed-in of biogas into the natural gas grid. Aside from the economic considerations that are leading investors to prefer other investment opportunities there are also a number of unresolved technical issues relating to the feed-in of biogas. Furthermore, network operators find themselves confronted with considerable legal uncertainty as they process grid connection applications, i.e. in the time interval from application submission until contract conclusion. In spite of being allowed only 3 months for processing connection applications, grid operators are required to bind themselves to a high degree in approving an application. This is a particular cause of difficulty given the as yet unresolved technical problems and is accordingly subject to controversy. In those difficult cases where it not possible to guarantee year-round feed-in of biogas into the grid because of unavailability of deodorant plants that would be needed for the ability to backfeed biogas into upstream grids, resolution would often nevertheless be possible if it was clearly indicated that use of a ''bypass solution'' as a means of ensuring overall cost-effectiveness would be accepted as a capacity-enhancing measure for purposes of cost allocation. This would provide grid operators a way of reliably circumventing the technical difficulties associated with deodorisation, enabling them to connect biogas production plants to the grid without having to deal with these technical issues which still await their final resolution. Under the law currently in force there is no legal impediment, subject to the specifics of the individual case, to accepting a bypass solution as a capacity enhancing measure. It would help grid operators in obtaining legal certainty, and ultimately promote investment in biogas projects, if the legislature were to clarify these issues in the Gas Network Access Ordinance.

  17. Dynamic computed tomography after bolus injection and infusion of perfluorooctylbromide (PFOB). Computertomographische Untersuchungen zur Dichtekinetik nach Bolusinjektion und Infusion von Perfluorooctylbromid (PFOB). Tierexperimentelle Untersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Adam, G.; Guenther, R.W.; Goertz, H.; Schiffer, C. (Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik); Prescher, A. (Technische Hochschule Aachen (Germany). Inst. fuer Anatomie); Bruchmueller, K. (Technische Hochschule Aachen (Germany). Inst. fuer Versuchstierkunde); Limmer, J. (Boehringer Ingelheim GmbH (Germany))

    1992-05-01

    We investigated the enhancement of the liver, the spleen, and of induced abscesses and the abdominal vessels after administration of 3 g/kg bodyweight Perfluoroocytlbromide (PFOB) on an animal model. Twenty-one rabbits each received the contrast medium as bolus injection and as slow infusion over half an hour. CT was performed between 2 and 48 hours after contrast medium application. Peak enhancement of the liver, the spleen and the liver abscess membrane was found between 24 and 48 hours after PFOB administration, independently of the application mode. Peak enhancement of the abdominal aorta and the IVC was observed within two hours after bolus injection. In this rabbit model PFOB permits best delineation of the vessels after bolus injection within the first two hours, while CT imaging of the liver, the spleen and the liver abscess membrane is best between 24 and 48 hours after contrast medium application, independent of the injection velocity. (orig.).

  18. Cathodic corrosion protection in a gas distribution grid. Operational experience in five years of operation; Kathodischer Korrosionsschutz in einem Gasverteilungsnetz. Betriebserfahrung nach fuenf Jahren

    Energy Technology Data Exchange (ETDEWEB)

    Poka, Werner [Stadtwerke Straubing (Germany); Gaugler, Hans; Steiger, Oliver [Stadtwerke Muenchen (Germany)

    2011-07-01

    In late 2001, Stadtwerke Straubing in Bavaria decided on cathodic corrosion protection of the Straubing low-pressure grid, with about 120 km of steel pipes. Planning started in early 2002 in cooperation with Stadtwerke Munich (SWM). Three years later, in December 2005, the last of the 25 grid sections was integrated in the cathodic corrosion protection system. This was followed by two years of monitoring, documentation, and measurements. The effectiveness of the cathodic corrosion protection system was proved for the whole low-pressure grid. Cost was reduced and availability enhanced. The project is discussed in detail, including economic efficiency, leak frequency and condition monitoring on the basis of measurements.

  19. Changes in the enchytraeid fauna of a moder soil beech stand after liming. Veraenderungen der Enchytraeidenfauna in einem Sauerhumus-Buchenwald nach Bestandeskalkung

    Energy Technology Data Exchange (ETDEWEB)

    Schoch-Boesken, J. (Duesseldorf Univ. (Germany). 2. Zoologisches Inst.); Greven, H. (Duesseldorf Univ. (Germany). 2. Zoologisches Inst.)

    1989-01-01

    A survey of the enchytraeid fauna before and two years after liming of a beech forest and comparison with an untreated area (Luzulo-Fagetum) reveal changes in the number of individuals/m[sup 2], number of species. Shannon-Weaver-Index and Evenness, particularly when individual soil horizons are considered. These changes obviously are related to the elevated pH of the soil after liming. pH-preferences of enchytraeids, whose dominances are strongly affected by liming, are shown. (orig.)

  20. Pulsed magnetic fields and their assessment according to the accident prevention regulation BGV B11; Gepulste magnetische Felder und Ihre Bewertung nach der Unfallverhuetungsvorschrift BGV B11

    Energy Technology Data Exchange (ETDEWEB)

    Heinrich, H. [2h-engineering, Hausen (Germany)

    2004-07-01

    The accident prevention regulation BGV B11 - Electromagnetic Fields - contains a method for the assessment of pulsed fields. This paper gives valuable hints and background information and presents a new tool for the computer-based assessment of these fields. (orig.)

  1. Restoration of intact ground waters and surface waters in the post-mining landscape; Wiederherstellung intakter Grund- und Oberflaechengewaesser nach dem Braunkohlenbergbau

    Energy Technology Data Exchange (ETDEWEB)

    Merkel, Broder; Schipek, Mandy [Technische Univ. Bergakademie Freiberg (Germany); Scholz, Guenter; Rabe, Wolfgang; Clauss, Denny [MOVAB-D GmbH, Lauta (Germany)

    2011-12-15

    The restoration of the territories of former brown coal mining increasingly requires special efforts for the protection of affected ground waters and surface waters. With newly developed methods (the so-called inlake technology), recently various solutions to neutralize acidic mining lakes could be created. Simultaneously, this improves the water quality of adjacent aquifers at reasonable financial cost.

  2. Long-Wave Radiation Divergence over Water and Land from Measurement and Calculation (Die Langwellige Strahlungsdivergenz ueber Wasser und ueber dem Festen Boden nach Messung und Rechnung),

    Science.gov (United States)

    surface temperature field. If these are eliminated, which is relatively simple over a water surface, the differences between calculated and measured...divergences at these levels is less than 20%, on the average. The relative variation of the divergence with height is somewhat greater over water than over land, due to the different temperature profiles. (Author)

  3. After Fukushima? On the educational and learning theoretical reflection of nuclear disasters. International perspectives; Nach Fukushima? Zur erziehungs- und bildungstheoretischen Reflexion atomarer Katastrophen. Internationale Perspektiven

    Energy Technology Data Exchange (ETDEWEB)

    Wigger, Lothar; Buenger, Carsten (eds.) [Technische Univ. Dortmund (Germany). Bereich Allgemeine Erziehungswissenschaft; Platzer, Barbara [Technische Univ. Dortmund (Germany)

    2017-08-01

    The book on the educational and learning theoretical reflection of nuclear disasters as a consequence of Fukushima includes contributions on the following issues: pedagogical approach: children write on Fukushima, description of the reality as pedagogical challenge; lessons learned on the nuclear technology - perspectives and limits of pedagogical evaluation: moral education - Japanese teaching materials, educational challenges at the universities with respect to nuclear technology and technology impact assessment; education and technology - questions concerning the pedagogical responsibility: considerations on the responsibility of scientists, on the discrepancy between technology and education, disempowerment of the public by structural corruption - nuclear disaster and post-democratic tendencies in Japan.

  4. Obligatory inquiries concerning buried pipelines in case of intended excavations on private ground; Zur Erkundigungspflicht nach erdverlegten Versorgungsanlagen bei Tiefbauarbeiten auf privaten Grundstuecken

    Energy Technology Data Exchange (ETDEWEB)

    Schulze, O.

    2006-09-15

    If inquiries concerning buried pipelines in case of intended excavations on private ground are neglected, this may have dramatic consequences. As an example, at Griselenghein near Ath, Belgium, excavations damaged the gas pipeline on 30 July 2004, and 18 were killed during the subsequent explosion. The contribution outlines cases in which inquiries concerning buried pipelines in case of intended excavations on private ground are obligatory. It points out regulations that come into force in case of neglect, and the potential contributory negligence of the utility if pipelines are not buried deep enough. (orig.)

  5. The prohibition order according to paragraph 5 S. 4 EnWG; Die Untersagungsverfuegung nach paragraph 5 S. 4 EnWG

    Energy Technology Data Exchange (ETDEWEB)

    Rauch, Karsten [WSW Netz GmbH, Wuppertal (Germany)

    2011-02-10

    The introduction of prosecutorial investigation on suspicion of delaying the insolvency proceedings published in the autumn 2010 results to a general question of whether and to what extent a concomitant intervention of the regulatory authorities is indicated. Central to this are the basis for authorization given in paragraph 5 S. 4 Energy Economy Law and the related prohibition authority.

  6. Nuclear industry and nuclear supervision in Japan prior to and after Fukushima; Atomwirtschaft und Atomaufsicht in Japan vor und nach Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Spatz, Philipp

    2012-06-15

    The Japanese nuclear industry owes its rise to the american message 'atoms for piece' of President Eisenhower. The Japanese reactors were built in the United States of America. The Nuclear Supervision was marked by the sponsoring spirit at the expense of security. Therefore, Fukushima was no accident. But Japan now creates a law on renewable energies. It remains unclear whether all 54 nuclear reactors being shut down jet will be connected to the power distribution line. In any case, the power supply of the country did not collapse.

  7. Functional estimation of kidneys after extracorporeal shock wave therapy (ESWL) by clearance. Funktionsbeurteilung der Nieren nach extrakorporaler Stosswellenlithotripsie (ESWL) mittels Nieren-Clearance

    Energy Technology Data Exchange (ETDEWEB)

    Sydow, K.; Kirschner, P.; Brien, G.; Buchali, K.; Frenzel, R. (Humboldt-Universitaet, Berlin (Germany). Medizinische Fakultaet)

    1991-10-01

    35 patients were scintiscanned with 99m-Tc-DTPA to determine the effects of extracorporeal shock waves used to desintegrate renal concrements may have on the patients renal function. The therapy was conducted using a standard Lithostar unit (Siemens) (20 patients) and an additional overtable module (15 patients). Functional scintigraphy was performed using a gamma camera before lithotripsy, and on the first day after it. Further control investigations were performed one or two weeks later and two till six months later. In both groups most of the patients developed temporary restrictions in renal function, some of them irreversible restrictions. Functional losses were found to be less severe with the use of the overtable module than with the standard Lithostar unit. (orig.).

  8. Evaluation and optimization of groundwater protection programs according to EU-Water framework directive; Bewertung und Optimierung von Grundwasserschutz-Massnahmenprogrammen nach der EU-Wasserrahmenrichtlinie

    Energy Technology Data Exchange (ETDEWEB)

    Kuhr, Petra; Kunkel, Ralf; Wendland, Frank [Forschungszentrum Juelich GmbH (DE). Inst. fuer Chemie und Dynamik der Geosphaere (ICG) - Inst. 4: Agrosphaere; Baron, Ute; Voigt, Hans-Juergen [Technische Univ. Cottbus (Germany). Lehrstuhl fuer Umweltgeologie

    2011-03-15

    In order to evaluate and optimize programmes of measures according to EU-Water framework directive a methodology has been developed which consists of three consecutive parts. In the first part the interrelations between matter inputs (contaminations), observed matter concentrations in groundwater and the hydrogeological system are analyzed based on a ''conceptual model''. Based on this a consistent evaluation of the extent of pollutant reduction necessary to reach good status of groundwater is carried out in the second part. The third part is an evaluation of the time gap between the introduction of a measure and its impact on the status of groundwater. The derived methodology is predominately based on digital datasets as input data which are available on the level of Germany's Federal States. Adapted to the sources of contamination of groundwater the methodology was successfully tested for diffuse nitrate sources in two regions in Lower Saxony/Northrhine-Westfalia and Hesse and for point sources in one region in Brandenburg. (orig.)

  9. Die germanische Gießereiwerkstatt in Pasohlávky (Bez. Břeclav). Ein Beitrag zur Frage Fernhandels- und Kulturbeziehungen nach den Markomannenkriegen

    Czech Academy of Sciences Publication Activity Database

    Tejral, Jaroslav

    2006-01-01

    Roč. 97, - (2006), s. 133-170 ISSN 0031-0506 R&D Projects: GA ČR GA404/05/2455 Institutional research plan: CEZ:AV0Z80010507 Keywords : Pasohlávky Moravia * metal casting workshop Subject RIV: AC - Archeology, Anthropology, Ethnology

  10. Compulsory procurement of emission allowances. How will things will continue after the Copenhagen conference?; Emissionszertifikatepflichten fuer Kraftwerke. Wie geht es weiter nach der Kopenhagen-Konferenz?

    Energy Technology Data Exchange (ETDEWEB)

    Telke, Juergen [Kiel Univ. (Germany). Rechtswissenschaftliche Fakultaet

    2010-03-15

    German power plants are obliged to hold emission allowances for their carbon dioxide emissions. This obligation is largely established by the Kyoto Protocol, which was approved in 1997 and entered into force in 2005 and which specifies binding emission reduction goals for 37 industrial states. Because this agreement is only valid until the end of 2012, negotiations were held for a follow-on agreement in Copenhagen in mid-December 2009. This article explains the current legal situation as laid down in the Kyoto Protocol and the EU Emission Trade Directive that followed from it. It goes on to analyse the impact of the Copenhagen conference on the emission allowance trade and gives appropriate recommendations for action for German power plants.

  11. Determination of the biogas and methane yield of selected energy crops. [NAchWAchsende ROhstoffe]; Ermittlung der Biogas- und Methanausbeute ausgewaehlter Nawaro

    Energy Technology Data Exchange (ETDEWEB)

    Ohl, Susanne

    2011-11-15

    The aim of this paper is the characterization of substrate quality and methane yield of different energy crops, which were cultivated in Schleswig-Holstein. The specific methane production of 224 variants was determined in with Hohenheim biogas yield test (HBT), 72 variants were investigated in a common batch test. The specific methane production (HBT) is 359-371 l{sub N}/kg{sub oDM} for wheat, 358-378 l{sub N}/kg{sub oDM} for maize and 341-372 l{sub N}/kg{sub oDM} for perennial ryegrass. The results for the specific methane production are due to a systematic offset in the batch experiment always below those of the HBT. Silages achieve higher gas yields than fresh substrates. The mass losses, which occur during ensiling, were compensated due to the higher gas yields. Maize is compared with other energy crops superior in terms of the yield per hectare. The experimentally determined methane yields showed a good agreement with calculated theoretical methane yields (method of WEIssBACH 2008, 2009).

  12. Principles and concept 1993 of the systemic cancer multistep therapy (sCMT). Extreme whole-body hyperthermia using the infrared-A technique IRATHERM 2000 - selective thermosensitisation by hyperglycemia - circulatory back-up by adapted hyperoxemia

    Energy Technology Data Exchange (ETDEWEB)

    Ardenne, M. von [Von Ardenne Inst. of Applied Medical Research, Dresden (Germany)

    1994-10-01

    The so-called Cancer Multistep Therapy was conceived by the author in 1965. It is a combined modality treatment with 3 process steps: Whole-body hyperthermia, hyperglycemia and hyperoxemia. The original therapy concept was further developed into a systemic Cancer Multistep Therapy (sCMT) of high efficiency and selectivity. An outline follows of this therapy and the actual state of the sCMT concept as per 1993 (new in timing, dosage, technique). Knowledge of the synergetic-additive efficiency of various groups of cytostatics reacting to the effects of the main treatment process steps (WBH+HG+HO) led in 1974 to an extension of the sCMT concept by including chemotherapy. In addition, a radiotherapeutical treatment was included in this concept as cancer cells clearly show a higher sensibility to radiation while under the influence of sCMT. Following the sCMT treatment, the patient remains under observation on an intensive in-patient basis for 24 hours before he or she is discharged for out-patient post-treatment care. The systemic tolerance of sCMT with minimal side-effects has been proven with several 100 patients and results have been published as part of the phase-I study. A first evaluation of the efficacy of sCMT was documented in the same study. (orig.) [Deutsch] 1965 wurde vom Autor die sogenannte Krebs-Mehrschritt-Therapie konzipiert. Es handelt sich hierbei um eine kombinierte Behandlung, bestehend aus Ganzkoerperhyperthermie, Hyperglykaemie und Hyperoxaemie. Die Weiterentwicklung der aelteren Therapiekonzepte bis hin zu einer systemischen Krebs-Mehrschritt-Therapie (sKMT) hoher Effizienz und Selektivitaet wird skizziert und der heutige Stand des sKMT-Konzeptes 1993 dargestellt. Es wurde ein strahlentherapeutischer Schritt in das Konzept aufgenommen, da unter der Wirkung der Hauptschritte eine deutlich erhoehte Strahlensensibilitaet der Krebszellen gegeben ist. Somit besteht das sKMT-Konzept 1993 aus den Hauptschritten Hyperthermie, Hyperglykaemie

  13. Experimental data for insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) in prevention of radiation myelopathy; Experimentelle Daten zum Einsatz von Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) zur Praevention einer Strahlenmyelopathie

    Energy Technology Data Exchange (ETDEWEB)

    Nieder, C. [Technische Univ. Muenchen (Germany). Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie; Price, R.E.; Rivera, B. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Veterinary Medicine and Surgery; Andratschke, N.; Kian Ang, K. [The Univ. of Texas, M. D. Anderson Cancer Center, Houston, TX (United States). Dept. of Experimental Radiation Oncology

    2002-03-01

    Background: Current models of radiation myelopathy provide a rationale for growth factor-based prevention strategies. Thus, we tested whether insulin-like growth factor-1 (IGF-1) and basic fibroblast growth factor (bFGF) alone or in combination modulate radiation tolerance of the rat cervical spinal cord. Materials and Methods: The cervical spinal cord of 68 adult Fisher F344 rats received a total dose of 30-36 Gy, given as a single fraction of 16 Gy followed by a second radiation dose of 14-20 Gy. Continuous intrathecal infusion of bFGF (44 rats) or saline (24 rats) into the cisterna magna was given concomitantly. A further experiment included 14 additional rats which were treated with subcutaneous injection of IGF-1 parallel to irradiation with a total dose of 34 Gy or 36 Gy. 20 rats received combined treatment, i.e. intrathecal infusion of bFGF plus subcutaneous injection of IGF-1, starting 24 hours before irradiation (total dose 33 Gy or 36 Gy) for a total of 4 days. Animals were followed until myelopathy developed or for a maximum of 12 months. Histopathologic examinations were performed post mortem. Results: Treatment with bFGF alone or IGF-1 alone increased the median time to myelopathy significantly. In the 36-Gy group, after combination treatment a comparable prolongation of latency was seen. Moreover, rats treated with 33 Gy and combined bFGF plus IGF-1 showed a significantly reduced risk of myelopathy, too (p = 0.0015). (orig.) [German] Hintergrund: Aktuelle Modelle zur Pathogenese der Strahlenmyelopathie lassen den praeventiven Einsatz von Wachstumsfaktoren sinnvoll erscheinen. Daher sollte ueberprueft werden, ob Insulin-Like Growth Factor-1 (IGF-1) und Basic Fibroblast Growth Factor (bFGF) als Einzelsubstanzen oder in Kombination die Strahlentoleranz des zervikalen Rueckenmarks von Ratten beeinflussen. Material und Methoden: Das Zervikalmark von 68 erwachsenen Fisher-F344-Ratten wurde mit zwei Einzelfraktionen bis insgesamt 30-36 Gy bestrahlt (16 Gy

  14. Radiological diagnostics of pediatric lungs; Radiologische Diagnostik der kindlichen Lunge

    Energy Technology Data Exchange (ETDEWEB)

    Beer, M.; Ammann, B. [Universitaetsklinikum Ulm, Klinik fuer Diagnostische und Interventionelle Radiologie, Ulm (Germany)

    2015-07-15

    wichtige Saeule zur Festlegung der Behandlung. Die besondere Bedeutung des Strahlenschutzes bei Kindern bedingt eine veraenderte Methodenwahl im Vergleich zu Erwachsenen. So haben Sonographie und MRT als ergaenzende und/oder weiterfuehrende Untersuchungsmethoden einen hoeheren Stellenwert als die Computertomographie im Erwachsenenalter. Haeufigste Fragestellung ist der Verdacht/Ausschluss einer Pneumonie. Dazu ist eine Thoraxaufnahme im a.-p.- oder p.-a.-Strahlengang ausreichend, teils flankiert von der Thoraxsonographie, um bei Beschwerdepersistenz letztere als Verlaufsbildgebung einzusetzen. Die Sonographie wird zudem zur Abklaerung auffaelliger Strukturen im Thoraxraum (Thymus, Sequester) eingesetzt und kann zur definitiven Klaerung fuehren. Der Roentgenthorax ist zudem ideal zur Abklaerung typischer Anpassungsstoerungen nach Geburt wie der transitorischen Tachypnoe (''wet lung disease'') oder dem Surfactantmangel. Durchleuchtungsuntersuchungen werden zur Abklaerung bei Aspirations- und/oder Ingestionsverdacht im Kleinkindalter eingesetzt. Die Computertomographie hat Bedeutung im Staging bzw. in der Nachsorge von Tumorerkrankungen. Technische Neuerungen (z. B. iterative Rekonstruktion) haben zu einer signifikanten Minderung der Strahlenexposition der CT gefuehrt. Die MRT wird derzeit nur vereinzelt zur Abklaerung bei Anlagestoerungen (Sequester) oder Tumorerkrankungen eingesetzt, ihr Potenzial zur Darstellung funktioneller Aspekte (Perfusion und Ventilation) laesst aber einen breiteren Einsatz in Zukunft erwarten. (orig.)

  15. Legal boundary conditions for direct marketing of 'green current' according to EEG 2012; Rechtliche Rahmenbedingungen fuer die Direktvermarktung von ''Gruenstrom'' nach dem EEG 2012

    Energy Technology Data Exchange (ETDEWEB)

    Breuer, Daniel [Landgericht Koeln (Germany); Osborne Clarke, Koeln (Germany). Bereich Energierecht

    2012-07-01

    The new direct marketing regime of the EEG 2012 provides incentives for operators of renewables-based systems to leave the fixed reimbursement scheme and integrate their systems in the markets, especially in the context of marketing of regulating power. However, it remains to be seen if this will reduce the cost of regulating energy supply, or at least keep it at the current level. In any case, plant operators should be careful in choosing their direct marketers and other partners and consultants. Simultaneous supply of regulating power is attractive especially for controllable and in some cases also for fluctuating renewable energy sources. This does comply with the priority principle and also with the prohibition of double marketing as is clearly stated in SEction 8 No. 3a.

  16. Langfristige Wiedereingliederung nach der beruflichen Rehabilitation : Ergebnisse einer Langzeituntersuchung der Arbeitsgemeinschaft Deutscher Berufsförderungswerke (Long-term reintegration after occupational rehabilitation : results of a longitudinal study by the working group of German occupational rehabilitation centres)

    OpenAIRE

    Beiderwieden, Kay

    2001-01-01

    "In Germany a complex system of rehabilitation has developed in which the occupational rehabilitation centres (Berufsförderungswerken) are allocated the occupational rehabilitation of the 'more difficult cases'. In order to investigate how many of those undergoing rehabilitation find work after completing the training measure, the occupational rehabilitation centres have been conducting so-called 'follow-up surveys' since the mid-1960s. In addition to short-term and medium-term follow-up surv...

  17. Air pollution abatement after the nuclear phase-out. 50 ideas for a new world. rev. and enl. new ed. 2012; Klimaschutz nach dem Atomausstieg. 50 Ideen fuer eine neue Welt

    Energy Technology Data Exchange (ETDEWEB)

    Ekardt, Felix

    2012-07-01

    The author of the book under consideration reports on how the energy policy turnaround and climate change could succeed politically and economically, as well as on how we personally outwit the overwhelming force of habit, convenience, consumer race and emotional limitations on the here and now.

  18. What comes after the petroleum? The AlkaPolP process as a fundament for a lignocellulose based biorefinery; Was kommt nach dem Erdoel? Der AlkaPoIP-Prozess als Basis fuer eine lignocellulosebasierte Bioraffinerie

    Energy Technology Data Exchange (ETDEWEB)

    Engel, Norman; Hundt, Martin; Schnitzlein, Klaus [Brandenburgische Technische Universitaet Cottbus (Germany). Lehrstuhl Chemische Reaktionstechnik; Schnitzlein, Michael G. [MCI Management Center Innsbruck (Austria)

    2013-04-15

    In times of climate change, scarcity of fossil fuels and a rapidly growing world population, the chemical industry faces great challenges in the 21st century. The raw material base of the organic chemical production in Germany consists of nearly 87 % of fossil resources and only 13 % from renewable resources. An expansion of the material use of starchy and sugary agricultural crops such as corn can not be sustainable due to the competition with food production. With the use of lignocelluloses-containing biomass, the main components cellulose, hemicellulose and lignin being indigestible for human beings, the 'tank- or-plate' conflict can be avoided.

  19. Implementation of a qualitymanagementsystem according to DIN EN ISO 9001 within the Department BG B of DSK; Einfuehrung eines Qualitaetsmanagementsystems nach DIN EN ISO 9001 im Bereich Bautechnik und Bergschaeden (BG B) der DSK

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, P. [Servicebereich Standort- und Geodienste der Deutschen Steinkohle AG, Herne (Germany); Sackel, M.; Pektas, E. [Sackel Ingenieure, Dortmund (Germany)

    2007-06-15

    In accordance to the improvement to the ''New DSK'', the department KG B turns more and more into a competent service partner. This challenge will be enduringly supported by the implementation of a Qualitymanagementsystem according to DIN EN ISO 9001. The implementation of a Qualitymanagementsystem is a multiple process. The integration during the regular business process forces experienced coaching. In this article, the basics of the QM-Standards will be explained and the implementation in department BG B will be introduced by certain examples. (orig.)

  20. Atomic energy law after the opt-out. Alive and fascinating. Report about the 14{sup th} German atomic energy law symposium 2012; Atomrecht nach dem Ausstieg. Lebendig und spannend. Tagungsbericht 14. Deutsches Atomrechtssymposium 2012

    Energy Technology Data Exchange (ETDEWEB)

    Leidinger, Tobias [Gleiss Lutz Rechtsanwaelte, Duesseldorf (Germany)

    2013-01-15

    Atomic energy law remains a living, fascinating subject matter. Nearly 200 participants were convinced of this impression at the 14{sup th} German Atomic Energy Law Symposium held in Berlin on November 19-20, 2012. Under the scientific chairmanship of Professor Dr. Martin Burgi, Ludwig Maximilian University of Munich, the German Federal Ministry for the Environment, Nature Conservation and Nuclear Safety (BMU), after an interruption of 5 years, again organized a scientific conference about practice-related topics of atomic energy and radiation protection law. Atomic energy law once again proved to be a reference area for sophisticated issues of constitutional law and administrative law above and beyond its technical confines. The agenda of the 14{sup th} German Atomic Energy Law Symposium featured a broad spectrum of topics ranging from backfitting of nuclear power plants to European atomic energy and radiation protection law, to challenges facing national legal systems in the execution of atomic energy law, to legal issues connected with decommissioning and waste management, and on to the topical subject of finding a repository site. The 14{sup th} German Atomic Energy Law Symposium, on the whole, again demonstrated that an open discourse between science and practice is able to furnish important contributions to the implementation of laws in a balanced way rooted in practice. Especially the contributions dealing with the independence of public authorities and their organization, the doctrine of the reservation of functions of the executive branch, and planning by laws contain additional provisions able to influence the continued development of administrative law also above and beyond atomic energy law. The BMU also referred to a decision just heard from Brussels to the effect that a new European Safety Directive would be published as early as in 2013. As a consequence of the nuclear stress tests conducted EU-wide, the Directive is to lay down provisions about transparency, material safety standards, and the separation of regulatory and supervisory authorities. In this way, the Commission opens up a broad field of topics which will ensure, also beyond the 14{sup th} German Atomic Energy Law Symposium, that atomic energy law will remain a living, fascinating subject matter. (orig.)

  1. Energy regulation at EU level. The role of the European Commission and ACER in the context of REMIT; Energieregulierung auf Unionsebene. Die Rolle der Europaeischen Kommission und der ACER nach der REMIT-VO

    Energy Technology Data Exchange (ETDEWEB)

    Konar, Selma [Sozietaet Becker Buettner Held, Muenchen (Germany). Energie- und Infrastrukturrecht

    2015-03-15

    The regulatory act of promulgating REMIT, the Regulation on Wholesale Market Integrity and Transparency, has highlighted the commanding position of both the European Commission and ACER, the Agency for the Cooperation of Energy Regulators, in the regulation of energy affairs in the European Union. Furthermore it has led to major changes in how surveillance is organized at the national level. The first part of this publication is dedicated to the organization of market surveillance following the promulgation of REMIT. It depicts the tasks of the European Commission and ACER in this context. The Regulation has accorded the authorities a central role in managing the European Union's responsibilities with regard to energy wholesale trade. The act of delegating such far-reaching competence to the authorities deserves careful review however. The article shows how, given ACER's lack of practical experience in market surveillance, as well as its lack of human resources, the task of surveilling the European energy wholesale market confronts the agency with a significant challenge. How successfully the EU energy agency will master this challenge will depend on a number of different factors. Stringent requirements will be needed for the data registration offices in order to ensure optimal data processing. National authorities and supervisory bodies should be made to participate in the data monitoring process. ACER's efficiency in surveilling the market will furthermore depend decisively on its IT infrastructure.

  2. Influence of clinical information on the diagnostic validity of MRI in the detection of abacterial sacroiliitis; Einfluss klinischer Informationen auf die diagnostische Wertigkeit der MRT bei der Frage nach einer abakteriellen Sakroiliitis

    Energy Technology Data Exchange (ETDEWEB)

    Remplik, P.; Schukai, O.; Roemer, F.W.; Fischer, W.; Buecklein, W.; Mott, K.; Bohndorf, K. [Klinik fuer Diagnostische Radiologie und Neuroradiologie, Klinikum Augsburg (Germany); Schalm, J. [3. Medizinische Klinik, Funktionsbereich Rheumatologie, Klinikum Augsburg (Germany)

    2005-06-01

    Purpose: to evaluate the influence of clinical information on the diagnostic validity of MRI in the detection of abacterial sacroiliitis. Evaluation of sensitivities, specificities, negative (NPV) and positive predictive values (PPV) for MRI with and without clinical information in comparison to a prior defined standard. Materials and methods: the results of routine MRI reports of 65 patients with the clinical suspicion of abacterial sacroiliitis referred by rheumatologists for MR assessment of the sacroiliac joints were retrospectively reviewed. These results were compared to the results of a blinded reading of the same examinations performed without any clinical information. The MRI protocol included T1-SE, STIR and T1-SE contrast-enhanced sequences with fat saturation. All patients were followed for at least four years. The standard of reference was defined by an experienced rheumatologist and included baseline and follow-up data (clinical, laboratory and imaging). Abacterial sacroiliitis was diagnosed in 19 patients. Results: under routine clinical conditions, MRI revealed a sensitivity of 94.7% and specificity of 97.8%. A PPV of 94.7% and a NPV of 97.8% were achieved. Without clinical information, MRI revealed a sensitivity and specificity of 64 and 80%, and a PPV of 49% and a NPV of 86%, respectively. Conclusion: the additional knowledge of clinical information for the MR diagnosis of abacterial sacroiliitis increases its diagnostic value for the assessment of abacterial sacroiliitis. (orig.)

  3. Delayed somatic effects following extended radiotherapy. Studies of 135 patients with Hodgkin's disease in long-term remission (Freiburg collective, treatment years 1948 to 1974). Untersuchungen ueber somatische Spaetschaeden nach ausgedehnter Strahlentherapie

    Energy Technology Data Exchange (ETDEWEB)

    Slanina, J

    1977-01-01

    A group of 135 patients who suffered from Hodgkin's disease with long-term remission following radiotherapy was investigated. By restricting the investigations to the patient group with long-term remission and correlative examinations, it was tried to differentiate between exclusive or principal delayed radiation effects and delayed effects due to other factors. The study reports about the most significant results obtained in the fields of catamnesis, laboratory diagnostics, hematology, pulmology, cardiology, thyroid function tests, neurology, andrology and dermatology. Due to the numerous detectable delayed effects the group of patients with long-term remission receives a special status. Although those effects are in no proportion to the deletary risks of an untreated Hodgkin's disease and though they are consequently tolerable in the present state of the therapeutic development, they must initiate the completion of the therapeutic concept including performance of radiotherapy and aftercare, because only then the risk for the patient provoked by these effects, which ranges beyond the malignity of this disease can be reduced or prevented.

  4. Is a monitoring of the remuneration of the grid utilization in the range of paragraph 315 BGB subsequent to the regulation possible?; Ist eine Ueberpruefung von Netznutzungsentgelten im Rahmen des paragraph 315 BGB nach der Regulierung noch moeglich?

    Energy Technology Data Exchange (ETDEWEB)

    Grigoleit, Andreas; Goetz, Katharina [Anwaltsbuero Andreas Grigoleit, Hamburg (Germany)

    2009-10-15

    Before the liberalisation of the power market in the year 1998, there were no possibility and necessity to examine the remuneration of grid utilization of the grid operators in an isolated manner for its equity. The aim of the liberalisation of the power market was to prevent the monopolistic position of the local current providers. The final break-through for the examination of the remuneration of grid utilization was obtained at 18th October, 2005. At this day, the Federal High Court (Karlsruhe, Federal Republic of Germany) decided that the grid operator has to determine the payment according to cheaper discretion. The equity has to be a subject to a determination of a judicial verification. The principle of reasonability would concretize the criterion of cheap discretion in the range of application of the regulation paragraph 315 of the German Civil Code (BGB). The paragraph 23a of the Energy Economy Law (EnWG) now requires the permission of the Federal Network Agency or of the national regulation authorities for the definition of the remuneration of grid utilization. Doubts about are partly announced whether these regulated remunerations are a subject of verification after paragraph 315 BGB.

  5. Stabilization of the cleaning of anaerobic waste water with the aid of activated sludge following receipts of hydrogen peroxide; Stabilisierung der anaeroben Abwasserreinigung durch Belebtschlamm nach Eintrag von Wasserstoffperoxid

    Energy Technology Data Exchange (ETDEWEB)

    Stupperich, E. [Ulm Univ. (Germany). Abt. Angewandte Mikrobiologie; Gerstmeir, R. [Ulm Univ. (Germany). Abt. Angewandte Mikrobiologie; Marqua, J. [Ulm Univ. (Germany). Abt. Angewandte Mikrobiologie; Rothfuss, A. [Ulm Univ. (Germany). Abt. Angewandte Mikrobiologie

    1996-12-31

    Some municipal and industrial sewage treatment plants comprise an aerobic and an anaerobic unit. However, discharge conditions may be such as to cause strong oxidants like hydrogen peroxide (H{sub 2}O{sub 2}) to enter the anaerobic unit. As measurements of the reduction-oxidation potential in an acidification stage showed, small concentrations of H{sub 2}O{sub 2}, already, may cause irreversible damage to the anaerobic bacterial strains living there. Adding activated sludge from the aerobic unit to such a system can prevent the damage. Probably, the enzyme catalase protects the anaerobic system against the oxydizing effect of hydrogen peroxide: this enzyme from aerobic bacteria and optionally aerobic bacteria causes the ecologically compatible decomposition of hydrogen peroxide into water and oxygen, which is substantially less reactive. Optionally aerobic bacteria, which are also added, protect the anaerobic system further by consuming this oxygen. (orig.) [Deutsch] Manche kommunalen und industriellen Klaeranlagen bestehen aus einer Aerobie und einer Anaerobie. Verschiedene Einleitungsbedingungen koennen aber dazu fuehren, dass in die Anaerobie starke Oxidationsmittel wie Wasserstoffperoxid (H{sub 2}O{sub 2}) gelangen. Messungen des Redoxpotentials in einer Versaeuerungsstufe zeigen, dass bereits geringe Konzentrationen an H{sub 2}O{sub 2} die dort lebenden anaeroben Bakterienkulturen irreversibel schaedigen. Wird aber einem solchen System Belebtschlamm aus der Aerobie zudosiert, so kann diese Schaedigung verhindert werden. Wahrscheinlich schuetzt das Enzym Katalase die Anaerobie vor der oxidierenden Wirkung des Wasserstoffperoxids. Dieses Enzym aus aeroben und fakultativ aeroben Bakterien zersetzt naemlich Wasserstoffperoxid oekologisch vertraeglich in Wasser und den bedeutend weniger reaktiven Sauerstoff. Zum Schutz der Anaerobie wird auch dieser Sauerstoff durch die zudosierten fakultativ aeroben Bakterien verbraucht. (orig.)

  6. Management of surface water bodies according to the new German Federal Water Act. Management objectives, minimum water-bearing, transmissibility and hydropower utilization; Die Bewirtschaftung der oberirdischen Gewaesser nach dem neuen Wasserrecht. Bewirtschaftungsziele, Mindestwasserfuehrung, Durchgaengigkeit, Wasserkraftnutzung

    Energy Technology Data Exchange (ETDEWEB)

    Kibele, Karlheinz

    2010-07-01

    The new German Federal Water Act came into effect on March 1, 2010. Since the federalism reform in the year 2006, the German Federation has got the opportunity to issue nationwide ordinances for overall water rights. Now, the Federation made use of this opportunity. However, on closer inspection the federal law turns out to be incomplete. The federal states are requested to complete the water rights so that they are ready to be enforced. In this contribution, several scopes will be exemplified. (orig.)

  7. 3D/4D architecture of chromosomal break point regions in the cell nucleus following irradiation of normal cells and tumor cells; 3D/4D Architektur von chromosomalen Bruchpunktregionen im Zellkern nach Bestrahlung von Normalzellen und Tumorzellen

    Energy Technology Data Exchange (ETDEWEB)

    Hausmann, M.; Cremer, C.; Friedl, A.; Dollinger, G.; Loebrich, M.; Friedland, W.

    2015-01-15

    The development of an effective analytical methodology for a correct description of oncogenic chromosomal aberrations is the challenge of medical radiobiology with respect to preventive therapeutic methods. Scope of the project was a better understanding of the behavior of break point regions dependent on the genome loci, the chromatin folding, the involved repair proteins and the beam quality with respect to an improvement and an efficient prognosis of the health consequences following radiation exposure. New microscopic insights in the normal cell nucleus are supposed to allow a better understanding of the spatial interactions on a molecular scale.

  8. Release procedure according to paragraph 29 StrlSchv on example of the nuclear research reactor TRIGA Heidelberg II; Durchfuehrung von Freigabeverfahren nach paragraph 29 am Beispiel des TRIGA Heidelberg II

    Energy Technology Data Exchange (ETDEWEB)

    Cremer, J. [Siempelkamp Nukleartechnik GmbH (SNT) (Germany); Sold, A. [Deutsches Krebsforschungszentrum Heidelberg (DKFZ) (Germany)

    2005-07-01

    The aim of this lecture is to show the schedule of a release procedure according to paragraph 29 StrlSchV on the example of the decommissioning of the nuclear research reactor TRIGA Heidelberg II. It is shown on the effort done by the radiation protection representative of this plant. Considering this example, starting with planning, application, survey and execution, the complex context of the release procedure is becomes apparent. Thereby the new applied measuring techniques that require a certain practice and the responsibility of the radiation protection representative in the radiation protection law play a relevant role. In such small facilities as the TRIGA Heidelberg II, the radiation protection staff are employed according to the plant's size and work is focussed on radiation protection research and laboratories. The decommissioning process with its wide range of radiation protection requirements represents new challenges which have to be coordinated with the present duties of the radiation protection representative. The supervision and the responsibility for the release procedure according to paragraph 29 are the largest and the most sensitive part of decommissioning of the nuclear research reactor TRIGA Heidelberg II. (orig.)

  9. Radioiodine therapy for combined disseminated and nodular thyroid autonomy. Results after using a correction term for the disseminated part; Radioiodtherapie bei kombinierter Schilddruesenautonomie. Ergebnisse nach Korrektur fuer disseminierte Anteile

    Energy Technology Data Exchange (ETDEWEB)

    Vogt, H.; Dorn, R.; Otto, I.; Sciuk, J. [Klinik fuer Nuklearmedizin, Klinikum Augsburg (Germany); Wengenmair, H.; Kopp, J. [Medizinische Physik und Strahlenschutz, Klinikum Augsburg (Germany)

    2006-07-01

    Aim: in combined focal and disseminated thyroid autonomy a variety of concepts in the treatment with radioiodine are used. The difference lies mainly in the calculation of the autonomous volume. This retrospective study shows a new method of calculating the autonomous volume. Patients and methods: in 398 patients with combined thyroid autonomy and good correlation of scintigraphically hot nodules and lesions defined by ultrasound the volume of the nodules is ascertained from scintigraphic and ultrasound parameters and the volume of the disseminated autonomous tissue is assessed with a weighting factor (VF). This factor is the ratio of impulse density in a ROI over the disseminated volume divided by the corresponding impulse density over the nodular volume of the thyroid scintigraphy. The sum of nodular volume and weighted perinodular volume gives the total autonomous volume. A standard radioiodine test gives the maximum iodine-131-uptake and effective half-life to calculate the activity to obtain a treatment dose of 400 Gy. Results: the rate of success with and without thyrostatic medication was 97% with an 18.6% rate of hypothyroidism observed from 4 months post therapy onwards. Conclusion: the use of the weighting factor VF in the treatment of combined autonomy leads to an excellent rate of success in patients with good correlation of functional imaging and ultrasound findings. (orig.)

  10. Search for new ways of production of diesel fuels from fats and oils on the basis of renewable raw materials; Suche nach neuen Wegen zur Gewinnung von Dieselkraftstoffen aus Fetten und Oelen auf der Basis von nachwachsenden Rohstoffen

    Energy Technology Data Exchange (ETDEWEB)

    Paetzold, Eckhard [Leibniz-Institut fuer Katalyse an der Universitaet Rostock e.V., Rostock (Germany); Schuemann, Ulrike [Rostock Univ. (Germany). Lehrstuhl fuer Kolbenmaschinen und Verbrennungsmotoren; Kragl, Udo [Leibniz-Institut fuer Katalyse an der Universitaet Rostock e.V., Rostock (Germany); Rostock Univ. (Germany). Inst. fuer Chemie

    2012-07-01

    Fats and oils are one of the oldest classes of chemical compounds used by humans. Natural fats consist of a hydrocarbon chain with double bonds and carboxylic/ester functions. They can be converted by hydrogenation and decarboxylation using heterogeneous catalysts at high temperature (450 C) and high hydrogen pressure (150 bar). Conversion of fats and oils by hydrogenation and decarboxylation with homogeneous noble metal catalysts at essential milder conditions for different applications as hydrotreated vegetable oil is possible as well. The reactions were studied by model compounds for the hydrogenation of double bonds e.g. linolenic acid and the decarboxylation of stearic acid. It was found that palladium nanoparticles can be used as catalyst in a two phase reaction. (orig.)

  11. Back to the green jewel. After a period of using fossil fuels, Costa Rica is returning to renewable energy sources; Zurueck zum gruenen Juwel. Nach einem Ausflug zu den fossilen Brennstoffen kehrt Costa Rica zurueck zu den erneuerbaren Energien

    Energy Technology Data Exchange (ETDEWEB)

    Bosworth, Melissa

    2010-07-15

    For more than two decades now, Costa Rica has been a Mecca for eco-tourists. Deep rainforests, empty beeches and an incredible variety of species have made the country into one of the forerunners of sustainability. This picture was marred by the fact that fossil fuels were getting more attention by the government recently. Now, however, Costa Rica is returning to renewable energy sources which had already supplied 100 percent of the country's total power. The government is even considering reimbursement tariffs for solar power. (orig.)

  12. Perspectives for the provision of biofuels. Classification of fuel options according to technical, economic and ecological criteria; Perspektiven der Biokraftstoffbereitstellung. Einordnung der Kraftstoffoptionen nach technischen, oekonomischen und oekologischen Kriterien

    Energy Technology Data Exchange (ETDEWEB)

    Scheftelowitz, Mattes; Mueller-Langer, Franziska [DBFZ Deutsches BiomasseForschungsZentrum gemeinnuetzige GmbH, Leipzig (Germany)

    2009-07-01

    Next to the use of more efficient, innovative technologies (including hybrid vehicles, electromobility) another important contribution to reducing greenhouse gas emissions in the traffic sector will have to come from biofuels. A wide variety of conversion pathways, each with numerous process alternatives, is available along the whole length of the ''well-to-wheel'' chain (i.e. starting from biomass cropping or recovery, through its supply and conversion to biofuel, including the necessary infrastructure, and ending with its final use). The present paper presents various biofuel options and compares them on the basis of systematic, economic and ecological criteria.

  13. Radiosynoviorhesis after total knee replacement: effective therapy of ''polythylene disease''; Radiosynoviorthese nach Knieendoprothesen: effektive Therapie bei ''Polyethylene disease''

    Energy Technology Data Exchange (ETDEWEB)

    Moedder, G.; Moedder-Reese, R. [Praxis fuer Nuklearmedizin/Inst. fuer Radiosynoviorthese, Koeln (Germany)

    2001-07-01

    Radiosynoviorthesis is an adequate therapy to remove the effects of polyethylene wear: {beta}-emission reduces growth of the foreign body granulomas and means an overkill for bacterias in penetration depth. This is a report about experience with 107 patients. (orig.) [German] Die Radiosynoviorthese ist eine geeignete Therapie, die Auswirkungen des Polyaethylenabriebs zu reduzieren oder zu beseitigen: Die Betastrahlung des intraartikulaer instillierten [{sup 90}Y] Yttrium bremst die Fremdkoerpergranulombildung und bedeutet einen Overkill fuer Bakterien in Strahlungsreichweite. Ueber Erfahrungen an 107 Patienten wird berichtet. (orig.)

  14. Nuclear war and other catastrophes. Civil and catastrophe protection in the Federal republic of Germany and the United Kingdom after 1945; Atomkrieg und andere Katastrophen. Zivil- und Katastrophenschutz in der Bundesrepublik und Grossbritannien nach 1945

    Energy Technology Data Exchange (ETDEWEB)

    Diebel, Martin [Zentrum fuer Zeithistorische Forschung, Potsdam (Germany)

    2017-07-01

    The book civil and catastrophe protection in the Federal republic of Germany and the United Kingdom after 1945 discusses the following issues: aerial defense and the atomic bomb (1945 - 1968), crises and catastrophes in the shadow of the bomb (1962 - 1978), civil defense and the comeback of the (nuclear) war (1976 - 1979), civil defense and the second ''Cold War'' (1979 - 1986), Chernobyl and the end of the Cold War (1979 - 1990), war, catastrophe and safety in the 20th century - a conclusion.

  15. Process for the fabrication of heat-insulating, especially ceramic solidified fiber bodies and their use. Verfahren zur Herstellung waermeisolierender, insbesondere keramischer, verfestigter Faserkoerper, nach dem Verfahren hergestellte Faserkoerper und deren Verwendung

    Energy Technology Data Exchange (ETDEWEB)

    Eschner, A.; Stein, H.

    1980-12-18

    According to the invention ceramic fibers (e.g. silicate) in the form of mats e.g. are soaked in an aqueous solution of aluminium phosphate. After that, the material is dried, tempered above 400/sup 0/C and heated to 800-1400/sup 0/C. This material can be used as heat insulating material for pipes, furnaces or wear lining for liquid metals.

  16. Timeresolved investigation of atomic order in tetrathiafulvalene-tetracyanoquinodimethane (TTF-TCNQ) monocrystals after excitation with ultrashort light pulses; Zeitaufgeloeste Untersuchung atomarer Ordnung in Tetrathiafulvalen-Tetracyanochinodimethan (TTF-TCNQ)-Einkristallen nach Anregung mit ultrakurzen Lichtpulsen

    Energy Technology Data Exchange (ETDEWEB)

    Sager, Christian

    2011-02-15

    This thesis describes time-resolved investigations of the atomic structure of one-dimensional organic molecular crystals after laser excitation of the photo-induced phase transition. There is a neutral to ionic phase transition in tetrathiafulvalene-chloranil-crystals (TTF-CA-crystals). At this phase transition a Peierls distortion occurs. A new model is introduced, that can explain the photo-induced phase transition in TTF-CY-crystals. This model is called charge density wave model of photo induced structural phase transition. There is a structural phase transition in tetrathiafulvalene-tetracyanochinodimethane-crystals (TTF-TCNQ-crystals). At this phase transition the one-dimensional metal TTF-TCNQ is transformed to an insulator. The phase transition is driven by the Peierls distortion. The charge density wave model is appropriate for description of the processes in TTF-TCNQ-crystals after laser excitation. The results of time-resolved measurements of the structure of TTF-TCNQ-crystals after excitation of the photo-induced phase transition can be anticipated with the charge density wave model. In the basis of these anticipated results, a time-resolved measurement for investigation of the atomic structure of TTF-TCNQ after excitation of the photo-induced phase transition is proposed. The time-resolved measurement should be performed at a beamline of a third generation synchrotron by the optical pump X-ray probe technique. The time-resolved measurement is prepared by an optical characterization and by static X-ray diffraction measurements. The results of the optical characterization and the static X-ray diffraction measurements are presented and analyzed. (orig.)

  17. Cancer incidence rate after diagnostic X-ray exposure in 1976-2003 among patients of a university children's hospital; Inzidenz von Kinderkrebs nach Roentgendiagnostik im Patientenkollektiv der Jahre 1976-2003 einer Universitaets-Kinderklinik

    Energy Technology Data Exchange (ETDEWEB)

    Hammer, G.P.; Zeeb, H.; Blettner, M. [Mainz Univ. (DE). Inst. fuer Medizinische Biometrie, Epidemiologie und Informatik (IMBEI); Seidenbusch, M.C.; Schneider, K. [Klinikum der Univ. Muenchen, Dr. von Haunersches Kinderspital (Germany). Abt. Radiologie; Regulla, D. [Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Neuherberg (Germany). Inst. fuer Strahlenschutz; Spix, C. [Mainz Univ. (Germany). Deutsches Kinderkrebsregister

    2010-05-15

    Purpose: Although the carcinogenic effect of ionizing radiation is well known, knowledge gaps persist on the health effects of low-dose radiation, especially in children. The cancer incidence rate in a cohort of 92,957 children diagnosed using X-rays in the years 1976-2003 in the radiology department of a large university clinic was studied. Materials and Methods: Individual radiation doses per examination were reconstructed using an algorithm taking into account the dose area product and other exposure parameters together with conversion factors computed specifically for the equipment and protocols used in the radiology department. Incident cancer cases in the period 1980-2006 were identified via record linkage to the German Childhood Cancer Registry using pseudonymized data. Results: A total of 87 cancers occurred in the cohort between 1980 and 2006: 33 leukemia, 13 lymphoma, 10 brain tumors, and 31 other tumors. The standardized incidence ratio (SIR) for all cancers was 0.99 (95 % CI: 0.79 1.22). A dose-response relationship was not observed for all cancers, leukemia and lymphoma or solid tumors. The cancer risks for boys and girls did not differ. Conclusion: No increase in the cancer incidence risk in relation to very low doses of diagnostic ionizing radiation was observed in this study. However, the results are compatible with a broad range of risk estimates. (orig.)

  18. Zur Materialfrage in der Implantatchirurgie des Deszensus: Vergleich zwischen Polypropylenvlies und dermaler porciner azellulärer Kollagenmatrix unter Berücksichtigung der Erfahrungen nach 7 Jahren Anwendung von Implantaten

    Directory of Open Access Journals (Sweden)

    Fischer A

    2004-01-01

    Full Text Available Ziel der Studie: Die Studie beschreibt Verwendung, Effektivität und Nebenwirkungen zwei verschiedener Implantate, die in der Senkungschirurgie verwendet werden und stellen die Ergebnisse in einen Zusammenhang mit den Erfahrungen mit anderen Implantaten seitens der Autoren und in der Literatur. Material und Methode: 180 Patientinnen mit verschiedenen Formen von Genitalprolaps werden mit Biomesh(R behandelt, 185 Patientinnen mit Pelvicol(R in der Zeit von Juli 2000 bis Dezember 2002. Die Ergebnisse werden verglichen. Ergebnisse: Die Verwendung von Implantaten ist häufig erforderlich, vor allen Dingen in Fällen eines stark zerstörten Beckenbodensystems oder bei Rezidiven. Die Verwendung von Netz-Implantaten in der Senkungschirurgie ist sicher, solange eine vernünftige Implantatstruktur zugrunde liegt. Beide in dieser Studie untersuchten Implantate erfüllen dies zufriedenstellend. Rezidiv- und Senkungszustände der benachbarten Kompartimente müssen getrennt ausgewertet werden, um eine Verwechslung zwischen einem schlechten Therapieergebnis (obwohl es eigentlich gut ist und Strukturschwächen in den (noch nicht behandelten Kompartimenten nicht in einem Topf zu werfen. Die Notwendigkeit einer Explantation, das Ausbilden von Abszessen oder die Abstoßungsreaktion wurden nur gesehen, wenn multifilamente mikroporöse Bänder oder entsprechend strukturiertes Nahtmaterial zur gleichen Zeit eingesetzt worden sind, oder wenn Blutergußbildung nicht durch subtile Hämostase während des Eingriffs unterdrückt werden konnte. Schlußfolgerung: Beide Materialien (Biomesh(R und Pelvicol(R liefern in der Verwendung bei implantatunterstützter Deszensus-Chirurgie gute Ergebnisse, gleich, wo sie auch eingesetzt werden. Es gibt keine signifikanten Unterschiede in der Effektivität oder in der Nebenwirkungsrate. Es bedarf nun der größer angelegten multizentrischen Studien, um alloplastisch unterstützte rekonstruktive Beckenbodenchirurgie nicht nur in den französischsprachigen Ländern zu etablieren.

  19. Visualization of pulmonary vein stenosis after radio frequency ablation for treatment of atrial fibrillation using multidetector computed tomography with retrospective gating; Darstellung von Pulmonalvenenstenosen nach Radiofrequenzablation zur Behandlung von Vorhofflimmern unter Verwendung der Multidetektor Computertomographie mit retrospektivem Gating

    Energy Technology Data Exchange (ETDEWEB)

    Trabold, T.; Kuettner, A.; Heuschmid, M.; Kopp, A.F.; Claussen, C.D. [Radiologische Klinik, Abt. fuer Radiologische Diagnostik, Univ. Tuebingen (Germany); Burgstahler, C.; Mewis, C.; Schroeder, S.; Kuehlkamp, V. [Medizinische Klinik III, Abt. fuer Kardiologie, Univ. Tuebingen (Germany)

    2003-01-01

    Purpose: With the number of radio frequency ablations (RFA) for treatment of chronic atrial fibrillation increasing, the diagnostic evaluation for RFA associated pulmonary vein stenosis is getting more important. This study investigates the feasibility of the visualization of pulmonary vein stenosis using non-invasive multidetector computed tomography. Materials and Methods: Twenty-eight patients were examined following RFA-treatment. A 4-slice (20 patients) and a 16-slice (8 patients) multidetector CT scanner (SOMATOM Volume Zoom and Sensation 16, Siemens, Forchheim, Germany) with retrospective gating was used to assess the pulmonary veins. Lesion severity was determined on a semi-quantitative scale (< 30%, 30 - 50%, > 50%). Results: CT was performed without any complications in all patients. Diagnostic image quality could be obtained in all examinations. The pulmonary veins showed lesions < 30% in four patients, lesions of 30 - 50% in five patients and a stenosis > 50% in one patient. Eighteen patients showed no lesions. Conclusion: Multidetector CT of the pulmonary veins seems to be able to visualize high-grade and low-grade lesions, but larger catheter-controlled studies are needed for further assessment of the diagnostic accuracy and clinical reliability of this noninvasive method. (orig.) [German] Ziel: Mit steigender Anzahl von Radiofrequenzablationen (RFA) zur Behandlung des chronischen Vorhofflimmerns wird die Diagnostik von RFA assoziierten Pulmonalvenenstenosen zunehmend wichtiger. Ziel dieser Studie war es, die Moeglichkeit der Darstellung von Pulmonalvenenstenosen mittels der nichtinvasiven Multidetektor-Computertomographie zu untersuchen. Material und Methoden: 28 Patienten wurden im Anschluss an eine RFA-Behandlung untersucht. Die Untersuchung wurde an einem 4-Zeilen- (20 Patienten) bzw. 16-Zeilen- (8 Patienten) Multidetektor-CT (SOMATOM Volume Zoom bzw. Sensation 16, Siemens, Forchheim, Germany) mit retrospektivem Gating durchgefuehrt. Der Schweregrad der Laesion wurde mittels einer semiquantitativen Skala eingeordnet (< 30%, 30 - 50%, > 50%). Ergebnisse: Die Multidetektor-CT konnte bei allen Patienten komplikationslos durchgefuehrt werden. Diagnostische Bildqualitaet wurde in allen Untersuchungen erzielt. 4 Patienten zeigten Laesionen der Pulmonalvenen < 30%, 5 Patienten Laesionen 30 - 50% und 1 Patient zeigte eine hoehergradige Stenose > 50%. Die uebrigen 18 Patienten zeigten keine Laesionen. Schlussfolgerungen: Mit der Multidetektor-CT der Pulmonalvenen scheint es moeglich zu sein, neben hoehergradigen Laesionen auch geringgradige Laesionen zu visualisieren. Groessere prospektive, katheterkorrelierte Studien sollten durchgefuehrt werden, um die diagnostische Genauigkeit und den klinischen Stellenwert dieser nichtinvasiven Methode zu evaluieren. (orig.)

  20. Good times end for the solar industry after the cut on reimbursement: A problem of constitutional law?; Das Ende der sonnigen Zeiten fuer die Solarindustrie nach der Kuerzung der Verguetungsansprueche. Ein (verfassungsrechtlicher) Vertrauensbruch?

    Energy Technology Data Exchange (ETDEWEB)

    Kment, Martin [EBS Univ. fuer Wirtschaft und Recht Wiesbaden (Germany). HEUSSEN-Stiftungslehrstuhl fuer Oeffentliches Recht und Europarecht, Recht der erneuerbaren Energien sowie Umwelt- und Planungsrecht

    2012-04-15

    As long as solar energy was funded by the state, the solar industry experienced a period of booming growth. The German government considered the cost too high and decided on drastic cuts. According to the contribution, the investor's faith in solar funding should be considered, and transition periods in the legal regulations should be decided. (orig.)

  1. The German energy policy as a consequence of Fukushima. The scientific discussion between nuclear phase-out and economic growth; Die deutsche ''Energiewende'' nach Fukushima. Der wissenschaftliche Diskurs zwischen Atomausstieg und Wachstumsdebatte

    Energy Technology Data Exchange (ETDEWEB)

    Radtke, Joerg [Bremen Univ. (Germany). Arbeitsgruppe fuer Energie und Infrastruktur; Hennig, Bettina (ed.) [Forschungsstelle Nachhaltigkeit und Klimapolitik, Leipzig (Germany)

    2013-07-01

    The book on the German energy policy as a consequence includes the following contributions: The German energy turnaround - scientific contributions. The energy turnaround in Germany - issue of interdisciplinary science. The transformation of the energy systems as social and technical challenge, - on the need of integrating energy research. Transformations and transformation blockades in the German energy system. The German energy turnaround in the context of international best practice. Energy turnaround also in Japan? - The chances of a nuclear phase-out. Possibilities and limits of public participation for the realization of an energy turnaround. Public energy in Germany - a model for participation? A plea for a comprehensive analysis of the energy turnaround in relation to the omnipresent crisis. Challenges and development in the German energy industry - consequences of the increasing percentage of renewable energies on the costs and the security of supply. Research funding and innovation promotion in the area of selected renewable energies. The economic chances of an energy turnaround. The need of appropriate monetary boundary conditions for the energy turnaround and the possibilities of an organization. The human factor in the context of the energy turnaround - environmental-psychological research approaches. The legal contribution to the energy turnaround. Vulnerability and resilience of energy systems. Geography of renewable energies -spatial constraints of a sustainable energy system. Critics and alternatives: The German energy turnaround that is no turnaround.

  2. „Die Schiffsreise war für mich eine Mischung aus Nostalgie, Melancholie, Unsicherheit“ - Die Überfahrt österreichischer Jüdinnen und Juden nach Südamerika

    Directory of Open Access Journals (Sweden)

    Philipp Mettauer

    2015-09-01

    Full Text Available Between 1938 and 1945, approximately 2.200 Austrians could flee from nationalsocialist persecution to Argentina. This article presents and analyses testimonies acquired through an oral history research project in Buenos Aires, with a focus on role and meaning of the passage and the sea voyage in these life stories. After time-consuming preparations, economic and bureaucratic struggles, violent persecution and nearly complete deprivation, the departure from Vienna and the separation from their former “Heimat” confirmed for these Austrian Jews a definite breach with their previous lives and the beginning of a stage of uncertainty and insecurity, in anxiety for the relatives they left behind. The transatlantic journey itself symbolizes a world in-between. On the one hand all emigrants had to pass through this transition under similar circumstances, but on the other hand the testimonies show a wide variety of experiences, depending on the individual situation, on the experiences made since the “Anschluss”, on the moment of escape and on the accommodation on board. The prospect of having to start from zero in a new country, without knowledge of the language, without housing and income, characterises the atmosphere of the testimonies, torn between the relief of escape from state repression and the uncertainty of the future. The “leisure time” during the journey which lasted three to four weeks offered an opportunity to look ahead and make plans for the future, but also to look back to the past and to consider the memoirs of a former existence. At the same time, some felt the need to enjoy the voyage and to try and forget their sorrows in this short period between departure and arrival. The interviewed persons were children, teenagers, or young adults when they were expelled. In order to give an insight into the experiences of the elder generations as well, I will quote from a private correspondence between family members written on the ship between Hamburg and Santa Fé. This essay also considers the Argentinian policies regarding immigration during the 1930s and 1940s, the different routes and embarking ports of escape, and finally reports about the arrival and the first impressions of the city of Buenos Aires.

  3. The competitive concession assignment according to paragraph 46 EnWG. Procedure without rules and arbitrators; Die wettbewerbliche Vergabe von Konzessionen nach paragraph 46 EnWG. Verfahren ohne Regeln und Schiedsrichter?

    Energy Technology Data Exchange (ETDEWEB)

    Schau, Goetz-Friedrich [Niedersaechsisches Ministerium fuer Wirtschaft, Arbeit und Verkehr, Hannover (Germany). Landeskartellbehoerde

    2011-01-15

    Presently, the concession assignment regarding to paragraph 46 EnWG (Energy Economy Law) has a great practical significance. For the first time, the concession assignment proceeds in the background of the liberalized and regulated electricity and natural gas markets. The half-hearted legal obligation to the competition of concession as well as the so far dormant supervisory authorities result in a substantial juridical insecurity in the process at the expense of the competitor.

  4. Use of residual fuels and biowaste of low calorific value for syngas production by the Noell conversion process; Der Einsatz niederkaloriger Energietraeger aus Reststoffen und Bioabfaellen zur Synthesegaserzeugung nach dem Noell-Konversionsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Schingnitz, M.; Goehler, P. [Noell-KRC Energie- und Umwelttechnik GmbH, Freiberg (Germany)

    1996-12-31

    By gasification with oxygen, municipal waste can be converted into a pure, burnable gas. The gas can be used like natural gas, e.g. in boilers and industrial furnaces, gas engines and gas turbines for heat and electric power generation, but also in chemical synthesis processes, e.g. methanol synthesis. If the right gasification technology is selected, the mineral constitutents of the waste materials can be melted down at the same time, e.g. into a granulate with a glass-like structure that can be used as constructional material. (orig) [Deutsch] Durch Vergasung mit Sauerstoff lassen sich kommunale Abfaelle in ein brennbares Gas umwandeln. Dieses Gas kann mit einfachen und bewaehrten verfahren von Schadstoffen wie Schwefelverbindungen befreit werden. Es laesst sich wie sauberes Erdgas umweltfreundlich in Kesseln und Industrieoefen einsetzen, in Gasmotoren oder Gasturbinen zur Erzeugung von Elektroenergie und Heizwaerme nutzen, aber auch zu chemischen Synthesen, beispielsweise von Methanol, verwenden. Bei geeigneter Wahl der Vergasungstechnologie gelingt es ausserdem, die mineralischen Bestandteile der Abfallstoffe prozessintern aufzuschmelzen und in ein beispielsweise als Baustoff verwertbares Schmelzgranulat mit glasartiger Struktur zu ueberfuehren. (orig)

  5. Socio-political Turmoil in Mali: The Public Debate Following the Coup d’État on 22 March 2012 Sozio-politische Turbulenzen in Mali: Die öffentliche Debatte nach dem Staatsstreich vom 22. März 2012

    Directory of Open Access Journals (Sweden)

    Sten Hagberg

    2012-01-01

    Full Text Available During the night between 21 and 22 March 2012, a group of young military officers overthrew Mali’s president, Amadou Toumani Touré. The group justified the coup by citing the inability of the regime to both deal with the crisis in the North and provide the army with the appropriate material and manpower to defend the national territory. The coup plunged Mali into violence, and caused a de facto partition of the country. The socio-political turmoil pitting different political and armed factions against each other has continued unabated and has been accompanied by intense mass media debates. In this report we focus on the Malian public debate. By looking at the political class, the international community, and the partition of the country, we analyse representations and stereotypes prevailing in this debate.In der Nacht vom 21. zum 22. März 2012 wurde der Präsident Malis, Amadou Toumani Touré, durch eine Gruppe junger Offiziere gestürzt. Die Gruppe rechtfertigte den Putsch, indem sie auf die Unfähigkeit des Regimes verwies, die Krise im Norden zu bewältigen und die Armee personell und materiell angemessen auszustatten, um die Grenzen das Landes verteidigen zu können. Der Staatsstreich stürzte Mali in eine gewaltsame Auseinandersetzung und führte zu einer faktischen Teilung des Landes. Die sozio-politischen Turbulenzen, in denen verschiedene politische und bewaffnete Gruppierungen gegeneinander antraten, haben seither unvermindert angehalten und wurden von intensiven Debatten in den Massenmedien begleitet. Der vorliegende Bericht konzentriert sich auf die öffentliche Debatte in Mali. Vor dem Hintergrund der politischen Entwicklung des Landes, der Positionen der internationalen Gemeinschaft und der Ursachen für die Teilung des Landes stellen die Autoren die Darstellungsweisen und Stereotypen dar, die in dieser Debatte Verwendung finden.

  6. Legal protection in the course and after the completion of procedures for awarding concessions in the energy management and water management; Rechtsschutz im Laufe und nach Beendigung des Konzessionsvergabeverfahrens in der Energie- und Wasserwirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Byok, Jan [Kanzlei Dr. Jan Byok, Duesseldorf (Germany); Dierkes, Mathias [Gelsenwasser AG, Recklinghausen (Germany)

    2012-07-15

    Water management concessions as well as energy management concessions are classified as service concessions or are treated in accordance to the principles of service concessions. The concessions are excluded from the regime of European procurement law and German antitrust law. Companies with an interest in a concession to be awarded are not situation without rights. Companies can review certain decisions judicially in connection with the awarding of concessions. The procedural question raises which legal process can be pursued in order to achieve an effective legal protection by the relevant interested party.

  7. Paul Ricœurs Suche nach einer Neubegründung der Menschenrechte und der Würde durch die Fähigkeiten und die Anwendung der phronèsis

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    Yvanka B. Raynova

    2016-12-01

    The aim of the following article is to reconstruct Paul Ricoeur's concepts of human rights and human dignity by exploring some little-known texts, and to exemplify how these concepts are connected to a specific philosophical conception of human being, which is grounded in a Dialectics between transcendence and incarnation, freedom and dependence, identity and difference, capability and fallibility (fragility. In doing so, I will argue that Ricœur interprets human dignity, which he has never explicitly defined, through the prism of human capabilities, especially of the capability of being responsible. This interpretation allows him to take a differentiated position in the current bioethical debates on the rights of "potential persons" (Embrio and to illustrate how the Aristotelian phronèsis can be used in (bioethical cases where decisions are difficult to take.

  8. What is the right way to run a transport route infrastructure?; Wie betreibt man Verkehrswegeinfrastruktur richtig? Behoerde oder Gesellschaft nach Handelsrecht: Welche Organisation garantiert in Zeiten knapper Kassen der oeffentlichen Hand hoehere Effizienz bei gleicher Qualitaet?

    Energy Technology Data Exchange (ETDEWEB)

    Scherz, Wolfgang [Hessische Landesbahn GmbH (HLB), Kassel (Germany). Infrastruktur-Agentur Hessen; Averkamp, Michael

    2010-07-01

    From the perspective of owners of publicly accessible transport route infrastructure - especially at a time when budgets are tight - there are two major questions that need to be posed and a rapid answer demanded: does a maintenance organisation established in the form of a public agency or a commercial enterprise yield better results, that is, higher and better output with declining input (agency versus company); and should an agency or transport infrastructure firm outsource all or part of its maintenance organisation (make-or-buy)? The authors, based on their experience gained in a variety of management functions in corporations and agencies as well as in executive coaching, provide quite different perspectives on these issues. (orig.)

  9. The large questions after Chernobyl. What are Becquerels and what are the hazards?; Die grosse Frage nach Tschernobyl. Was sind und wie misst man Bequerels, und wie gefaehrlich sind sie?

    Energy Technology Data Exchange (ETDEWEB)

    Maushart, Rupprecht

    2016-05-01

    In consequence of Chernobyl private persons and public officers wanted or had to measure radioactivity without any knowledge on the issue. Experiences form this situation are summarized and discussed with respect to the production of appropriate measuring instruments and reasonable descriptions.

  10. Monument protection and energy conservation. Status quo five years after the EnEV 2007; Denkmalschutz und Energieeinsparung. Stand der Dinge fuenf Jahre nach der EnEV 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-11-01

    The meeting ''Monument conservation and energy conservation'' at 9th February 2012 in Wiesbaden (Federal Republic of Germany) focuses on the status quo five years after the revised version of the Energy Saving Ordinance (EnEV) in the year 2007. Within this meeting the following lectures were held: (1) Monument conservation and energy conservation - Status Quo five years after the EnEV 2007 (Roswitha Kaiser); (2) Interior insulation with exterior hydrophic treatment - material appropriate and monument appropriate? (Anatol Worch, Michael Auras); (3) Hints regarding to planning, execution and quality assurance of a subsequent core insulation (Heinrich Wigger, Kerstin Stoelken, Britta Schreiber); (4) Comparison of different interior insulation materials (Rudolf Platte); (5) Urban structural energy study Winterthur (Reto Bieli); (6) Remodelling of an industrial plant protected as a historical monument - Historical window systems, exposed masonry and modern installations (Andr Kramm, Marcel Kremer); (7) Model project - Facade insulation with VIP panels at a Ernst-May building protected as a historical building in Frankfurt (Main) (Juergen Werner); (8) The former tax office Wiesbaden - Energetic strengthening (Klaus Daniels); (9) House of the Evangelical Church in Wiesbaden - Energetic strengthening of the facades (Dominik Loh); (10) Conservation versus comfort and energy demand - Potentials of optimization by means of a targeting controlled operation of plant-technical systems in a historical monument (Harald Garrecht); (11) Energy efficient construction - Compound insulation materials as a disposal problem for dismantling and renovation (Ulrich Langer, Thomas Egloffstein).

  11. Does man end up as a final disposal site for radioactive substances. Analyses, facts, background information. Life after the Chernobyl accident - and the consequences with regard to food. Endlagerstaette Mensch. Analysen, Tatsachen, Hintergruende. Nach Tschernobyl - Konsequenzen fuer unsere Ernaehrung

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, H

    1986-01-01

    The fire in the Russian reactor that spread sparks of fear and panic into millions of homes also is a challenge: We have to cope with the reality of life after the Chernobyl disaster, and what we first need is sound and proper information. What is to be learnt from the disaster. From the embarassing quarrel between our Government and Land governments about dose limits. Will politicians draw consequences. How good and efficient are current food quality controls. What do the consumers' associations say. What will anti-nuclear power groups do. The book in hand critically reviews the events and activities that followed the Chernobyl accident. It denounces the scandalous behaviour of authorities who created confusion rather than confidence, and the behaviour of those people who are playing a foul game with the people's fear. The author presents information in order to make the complex mechanisms of radioactivity and its effects comprehensible to the general public. He also discusses the problem of 'legally' irradiated food imported from other countries.

  12. Striking a balance of abberations and confusion. Information, reports and arguments in view of the changed situation after the Chernobyl reactor accident. Bilanz einer Ver(w)irrung. Informationen, Berichte und Argumente zum Umdenken nach Tschernobyl

    Energy Technology Data Exchange (ETDEWEB)

    Vester, F

    1986-01-01

    The author is striking a balance of abberations and confusion. While throwing light on the general disinformedness, the neglect of urgent measures and non-observance of existing laws he also explains why nuclear energy cannot be considered an economic energy source, why alternative energy sources are cheaper and that the nuclear power industry is to be made responsible for social conflicts which are threatening to seriously affect the basic political consensus.

  13. Search for solar axions with the X-ray telescope of the CAST experiment (phase II); Suche nach solaren Axionen mit dem Roentgenteleskop des CAST-Experiments (Phase II)

    Energy Technology Data Exchange (ETDEWEB)

    Nordt, Annika

    2009-10-14

    The CAST (CERN Solar Axion Telescope) experiment is searching for solar axions by their conversion into photons inside a transverse magnetic field. So far, no solar axionsignal has been detected, but a new upper limit could be given (CAST Phase I). Since 2005, CAST entered in its second phase where it operates with a buffer gas ({sup 4}He) in the conversion region to extend the sensitivity of the experiment to higher axionmasses. For the first time it is possible to enter the theoretically favored axion massrange and to give an upper limit for this solar axion mass-range (>0.02 eV). This thesis is about the analysis of the X-ray telescope data Phase II with {sup 4}He inside the magnet. The result for the coupling constant of axions to photons is: g{sub {alpha}}{sub {gamma}}{sub {gamma}}<1.6-6.0 x 10{sup -10} GeV{sup -1} (95%C.L.) for m{sub a}=0.02-0.4 eV. (2) This result is better than any result that has been given before in this mass range for solar axions. (orig.)

  14. Quantitatively evaluated dynamic MRT in rheumatoid arthritis of the knee joint. Follow-up after intraarticular steroid therapy. Quantitativ evaluierte dynamische Magnetresonanztomographie bei chronischer Polyarthritis des Kniegelenkes. Therapiekontrolle nach intraartikulaerer Kortisonapplikation

    Energy Technology Data Exchange (ETDEWEB)

    Koenig, H.; Bolze, X.; Wolf, K.J. (Klinikum Steglitz, FU Berlin, Radiologische Klinik und Poliklinik, Abt. fuer Radiologische Diagnostik und Nuklearmedizin (Germany)); Sieper, J. (Klinikum Steglitz, FU Berlin, Medizinische Klinik und Poliklinik, Abt. fuer Allgemeine Innere Medizin und Nephrologie (Germany))

    1992-08-01

    32 patients with chronic polyarthritis were examined by MRT. Following intra-articular application of 25 mg prednisolon, 18 patients were reexamined after two of three weeks and 7 out of 18 patients were re-examined after 8 to 16 weeks, both by MRT and clinically. After an initial double echo sequence, we carried out a dynamic series of FLASH measurements (TR 30, TE 10 ms, 70deg) following an intravenous bolus of 0.1 mmol gadolinium-DTPA. Single intensity-time curves were treated quantitatively in relation to the pannus, muscles and effusions. Two or three weeks after treatment the curve parameters showed a reduction in pannus vascularisation which remained constant for the 8 to 16 weeks of further observation. Contrast diffusion in the pannus is initially reduced but approaches the early measurements at the time of the second examination. (orig.).

  15. Adaptation of the pressure test for borehole heat exchangers in accordance with DIN V 4279-7; Anpassen der Druckpruefung nach DIN V 4279-7 fuer Erdwaermesonden aus Polyethylen

    Energy Technology Data Exchange (ETDEWEB)

    Rohner, E.

    2005-07-01

    The goal of this project was to develop a pressure test in accordance with DIN V 4279-7 to identify possible leakages of borehole heat exchanger systems. The presented pressure test serves predominantly as quality assurance. The test shall prevent that leaking borehole heat exchangers are put into operation. Since January 1{sup st}, 2005 the test, based on this report, is integral part of the seal of approval 'Erdwaermesonde' delivered by the Association for the Promotion of Heat Pumps in Switzerland ('Foerdergemeinschaft Waermepumpen Schweiz'). The presented methodology allows accurate and fast measurements of the tightness of borehole heat exchanger systems (test duration: about 1.5 h). A measuring apparatus was developed which allows to proceed easily with the pressure test. Pressure test and measuring apparatus have been already successfully used. (author)

  16. Efficient document management by introduction of a new, dynamic quality manual application according to DIN EN ISO 9001:2000; Effiziente Qualitaetsmanagementdokumentation durch Einfuehrung eines neuen, dynamischen Qualitaetsmanagementhandbuchs nach DIN EN ISO 9001:2000

    Energy Technology Data Exchange (ETDEWEB)

    Pache, G.; Saueressig, U.; Baumann, T.; Langer, M.; Kotter, E. [Universitaetsklinikum Freiburg (Germany). Abt. Roentgendiagnostik; Duerselen, L. [DxD Consulting, Degern (Germany)

    2008-06-15

    Purpose: Evaluation of the impact of a new, dynamic computer-aided quality manual application (QMA) regarding the acceptance and efficiency of a quality management system (QMS) according to DIN EN ISO 9001:2000. Materials and Method: The QMA combines static pages of HTML with active content generated from an underlying database. Through user access rights, a hierarchy is defined to create and administer quality documents. Document workflow, feedback management and employee survey were analyzed to compare the performance of the new QMH with the formerly used static versions. Results: Integration of a document editor and automated document re-approval accelerated the document process by an average of 10 min. In spite of an increase of the yearly document changes of 60%, the administration effort was reduced by approximately 160 h. Integration of the feedback management system into the QMA decreased handling time from an average of 16.5 to 3.4 days. Simultaneously the number of feedback messages increased from 160 in 2005 to 306 in 2006. Employee satisfaction was raised (old: 3.19{+-}1.02, new: 1.91{+-}0.8). The number of users who partook in the QMA more than once a week also increased from 29.5% to 60%. Conclusion: The computer-aided quality manual application constitutes the basis for the success of our QMS. The possibility to actively participate in the quality management process has led to broad acceptance and usage by the employees. The administration effort was able to be tremendously decreased as compared to conventional QMS. (orig.)

  17. Use of residual fuels and biowaste of low calorific value for syngas production by the Noell conversion process; Der Einsatz niederkaloriger Energietraeger aus Reststoffen und Bioabfaellen zur Synthesegaserzeugung nach dem Noell-Konversionsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Schingnitz, M; Goehler, P [Noell-KRC Energie- und Umwelttechnik GmbH, Freiberg (Germany)

    1997-12-31

    By gasification with oxygen, municipal waste can be converted into a pure, burnable gas. The gas can be used like natural gas, e.g. in boilers and industrial furnaces, gas engines and gas turbines for heat and electric power generation, but also in chemical synthesis processes, e.g. methanol synthesis. If the right gasification technology is selected, the mineral constitutents of the waste materials can be melted down at the same time, e.g. into a granulate with a glass-like structure that can be used as constructional material. (orig) [Deutsch] Durch Vergasung mit Sauerstoff lassen sich kommunale Abfaelle in ein brennbares Gas umwandeln. Dieses Gas kann mit einfachen und bewaehrten verfahren von Schadstoffen wie Schwefelverbindungen befreit werden. Es laesst sich wie sauberes Erdgas umweltfreundlich in Kesseln und Industrieoefen einsetzen, in Gasmotoren oder Gasturbinen zur Erzeugung von Elektroenergie und Heizwaerme nutzen, aber auch zu chemischen Synthesen, beispielsweise von Methanol, verwenden. Bei geeigneter Wahl der Vergasungstechnologie gelingt es ausserdem, die mineralischen Bestandteile der Abfallstoffe prozessintern aufzuschmelzen und in ein beispielsweise als Baustoff verwertbares Schmelzgranulat mit glasartiger Struktur zu ueberfuehren. (orig)

  18. New certification process starts. Pt. 2. Application of Building Information Modeling (BIM) for the certification according to DGNB; Zertifizierungsprozess auf ''neuen Beinen''. T. 2. Anwendung von Building Informationen (BIM) zur Zertifizierung nach DGNB

    Energy Technology Data Exchange (ETDEWEB)

    Essig, Bernd [SCHOLZE Consulting GmbH, Leinfelden-Echterdingen (Germany). Geschaeftsbereich Ingenieur-Beratungsleistungen in Facility-, Informations-, Qualitaets-, Nachhaltigkeitsmanagement und Energieberatung; Ernst, Tatjana [SCHOLZE Consulting GmbH, Leinfelden-Echterdingen (Germany)

    2013-04-01

    The overall life cycle plays a significant role in the certification by German Sustainable Building Council (Stuttgart, Federal Republic of Germany). In order that certification becomes much more than only a documentation, comprehensive data are requested already in an early phase of planning. Early investigations of alternatives may have a significant influence on the life cycle of a building. But, from where do the auditors achieve these amounts of data without overcharging the partners involved in the planning process with questions. The Building Information Modelling contributes to the development of the future enhancement of process quality by an innovative information management.

  19. Abusive behaviour of grid operators within concession procedures and grid acquisitions with respect to paragraph paragraph 30, 32 EnWG; Missbraeuchliches Verhalten von Netzbetreibern bei Konzessionierungsverfahren und Netzuebernahmen nach paragraph paragraph 30, 32 EnWG

    Energy Technology Data Exchange (ETDEWEB)

    Becker, Peter [ZNER (Germany); Humboldt-Univ. zu Berlin (Germany). Energierecht; Becker Buettner Held, Berlin (Germany); Templin, Wolf [Kanzlei Boos Hummel und Wegerich, Berlin (Germany)

    2013-02-15

    The competition for the power distribution systems has inflamed all over in the Federal Republic of Germany due to the fact that concession contracts have a running time of only twenty years and end not later than 31st December, 1994. Those concession contracts will end currently. Thus the old affiliated companies have to fear for their market position. Under this aspect, the authors of the contribution under consideration report on the abusive behaviour of grid operators at licensing procedures and grid acquisitions with respect to paragraph paragraph 30, 32 Energy Economy Law. The authors report on the unilateral monopole consideration of the authorities and court as well as on the abusive behaviour of the old concessionaires from the standpoint of energy law and cartel law.

  20. Role of Hypoxia-inducible factor-1 and its target genes in human lung adenocarcinoma cells after photon- versus carbon ion irradiation; Expression HIF-1-abhaengiger Gene in humanen Lungenadenokarzinom (A549)-Zellen und deren Regulation nach Photonen- und Schwerionenbestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Bill, Verena Maria

    2013-11-26

    Exposed to hypoxia tumor cells are notably resistant to photon irradiation. The hypoxiainducible transcription factor 1α (HIF-1α) seems to play a fundamental role in this resistance, while its role after heavy-ion beam remains unknown. The intention of this study was to determine how A549-cells (non-small-cell lung carcinoma) react in different oxygenation states after irradiation with photons or heavy ions, particularly in regards to their expression of HIF-1 target genes. Resistance of hypoxic A549 cells after photon irradiation was documented by cellular and clonogenic survival. In contrast, cellular survival after heavy-ion irradiation in hypoxic cells was not elevated to normoxic cells. Among the oxygen dependent regulation of HIF-1 target genes, gene expression analyses showed an increased expression of GLUT-1, LDH-A, PDK-1 and VEGF after photon irradiation but not after heavy-ion irradiation after 48 hours in normoxic cells. As expected, CDKN1A as inhibitor of cell cycle progression showed higher expression after both radiation forms; interestingly CDKN1A was also in an oxygen dependent manner lightly upregulated. In western blot analyses we demonstrated a significant increase of HIF-1 and GLUT-1 caused by hypoxia, but only a tendency of increased protein level in hypoxia after photon irradiation and no changes after heavy-ion irradiation. Significantly higher protein level of secreted VEGF-A could be measured 72 hours after photon irradiation in normoxic cells by ELISA analyses. Controversially discussed, I could not detect an association between HIF-1 and SCF or Trx-1 in A549-cells in this study. Whereas Trx-1-expression was neither influenced by changed oxygen partial pressure nor irradiation, I could show increased SCF mRNA by quantitative Real Time-PCR and secreted protein level by ELISA after photon irradiation independent of oxygen state. In summary, this study showed that HIF-1 and its target genes (GLUT-1, LDHA; PDK, VEGF) and also SCF was increased after photon irradiation and therefore could take part in radioresistance of photon irradiation therapy in contrast to heavy ions. These results suggest a further benefit of the radiotherapy using heavy ions for non-small cell lung cancer.

  1. Vom Sprechen des Unsagbaren und vom Sehen des Unsichtbaren oder die essayistische Suche nach der verlorenen Ganzheit On Speaking about the Unspeakable and Seeing the Invisible or: The Search for Lost Entirety

    Directory of Open Access Journals (Sweden)

    Maria Marchetta

    2002-03-01

    Full Text Available Christina Scherer weist in ihrer Dissertation die strukturelle Äquivalenz zwischen einer essayistischen Filmästhetik und dem Prozess des Erinnerns auf. Ivens, Marker, Godard und Jarman thematisieren in und mit ihren Filmen die Unverfügbarkeit der Erinnerung und halten trotz ihres Zweifels an der Abbildbarkeit von Welt und ihrer Einsicht in die Uneinholbarkeit der Vergangenheit den Horizont der Möglichkeit von Erinnerung offen. In Essayfilmen sind es vor allem die selbstreflexive Selbstvergewisserung, die Einsicht in das unausweichliche Verfehlen der Vergangenheit und der melancholische Rückblick auf eine verloren gegangene Ganzheit, die einen fühlenden Verstand und ein denkendes Herz generieren.Christina Scherer’s dissertation points to the structural equivalence between the aesthetics of the essay film and the process of remembering. Ivens, Marker, Godard and Jarman make the unavailability of memory their central theme. Despite the filmmakers’ doubts about the possibility of replicating a true image of the world and their knowledge of the irretrievability of the past they nonetheless insist on the possibility of memory. Reflectively positioning oneself, acknowledging inevitable errors of the past, and looking back in melancholy on a lost entirety are some of the strategies in essay films which generate a sympathetic mind and a thinking heart.

  2. Investigations on pretreatment of waste prior to fermentation by percolation using the ISKA {sup registered} process; Untersuchungen zur Vorbehandlung von Abfaellen vor der Vergaerung mittels Perkolation nach dem ISKA {sup registered} -Verfahren

    Energy Technology Data Exchange (ETDEWEB)

    Santen, H. [Technische Univ. Braunschweig (Germany). FG Abfallwirtschaft; Fricke, K. [Technische Univ. Braunschweig (Germany). Lehrstuhl Abfallwirtschaft; Engelhard, T.; Widmer, C. [ISKA GmbH, Ettlingen (Germany)

    2004-07-01

    Waste treatment prior to fermentation is a key aspect in achieving economic efficiency. One process is presented here in particular: percolation, in which waste is hydrolyzed aerobically, treated mechanically, and washed out with the aid of process water. The process involves a percolation stage followed by a fermentation stage. The process water burdened with organic matter is passed into a fermentation reactor in which the organic components are reacted anaerobically into biogas and bacterial mass, and the process water is recirculated into the percolation reactor. (orig.) [German] Vergaerungstechnologien zaehlen zu den etablierten Verfahren zur Gewinnung regenerativer Energien aus Biomasse. Fuer die Energieeffizienz dieser Verfahren sind die Leistung der Vergaerungsstufe, die Hoehe der Verfuegbarkeit der anaerob abzubauenden organischen Substanzen und der spezifische Energiebedarf des Behandlungsverfahrens massgeblich. Eine Schluesselstellung fuer die Optimierung beider Faktoren nimmt die Abfallaufbereitung vor der Vergaerung ein. Eine Technoloie zur Aufbereitung vor der Vergaerung basiert auf dem Verfahren der Perkolation, in der der Abfall aerob hydrolysiert,mechanisch aufgeschlossen und durch Zugabe von Prozesswasser ausgewaschen wird. Das Verfahren besteht aus einer Aufbereitung - der Perkolation - sowie einer nachgeschalteten Vergaerung. Das mit vergaerbarer Organik beladene Prozesswasser wird einem Vergaerungsreaktor zugefuehrt, in dem die organischen Komponenten anaerob zu Biogas und Bakterienmasse umgesetzt werden. Das aufbereitete Prozesswasser wird anschliessend wieder dem Perkolationsreaktor zugefuehrt. (orig.)

  3. Experimental investigation of a non-equilibrium expansion flow after hydrogen/air combustion in hypersonic ramjet engines; Experimentelle Untersuchungen zur Nichtgleichgewichtsexpansionsstroemung nach Wasserstoff/Luft-Verbrennung in Hyperschall-Staustrahltriebwerken

    Energy Technology Data Exchange (ETDEWEB)

    Weisgerber, H.

    2002-03-01

    The exhaust gas flow in the model thrust nozzle under investigation is characterized by chemical and thermal (vibrational) non-equilibrium which is experimentally detected by differing rotational and vibrational temperatures in the supersonic region of the nozzle. An analytical method to determine the vibrational relaxation time from expansion experiments is presented and validated using literature data. The nitrogen vibrational temperature at the nozzle exit strongly depends on the relaxation time of collisions with water molecules; for this process a correlation from the literature is selected. The measurements are completed by an experimental and numerical analysis of velocimetry tracer particle motion in flows with strong velocity gradients and an experimental investigation of the causes and effects of laser beam distortions occurring in high enthalpy flows. So a reliable database is presented for a reacting flow in a model nozzle of rectangular cross-section which was already used to validate a CFD code including the model of thermal non-equilibrium effects. (orig.) [German] Die Stroemung eines Abgases in der untersuchten Modellschubduese ist charakterisiert durch chemisches und thermisches (vibratorisches) Nichtgleichgewicht, das durch die Abweichung der Vibrations- von der Rotationstemperatur des Stickstoffmolekuels im Ueberschallteil der Duese experimentell belegt wird. Eine Methode zur analytischen Ermittlung der Vibrationsrelaxationszeit aus Expansionsexperimenten wird vorgestellt und anhand von Literaturdaten validiert. Die entscheidende Groesse fuer die Vibrationstemperatur des Stickstoffs am Duesenaustritt ist die Relaxationszeit beim Stoss mit einem Wassermolekuel; aus den fuer diesen Vorgang vorliegenden Literaturangaben wird eine Korrelation ausgewaehlt. Zur Absicherung der Messungen wird zum einen das Folgeverhalten von zur Geschwindigkeitsmessung zugefuegten Partikeln in Stroemungen mit starken Geschwindigkeitsgradienten experimentell und numerisch analysiert; zum anderen werden die in Hochenthalpiestroemungen zum Teil beobachteten optischen Signalstoerungen bezueglich ihrer Ursachen und Auswirkungen experimentell untersucht. Es resultiert ein belastbarer Datensatz zur reagierenden Stroemung in einer Rechteckduese, an dem bereits ein numerisches Verfahren hinsichtlich der Modellierung thermischer Nichtgleichgewichtseffekte erfolgreich validiert werden konnte. (orig.)

  4. After swimming one goes on the ice. Multifunctional complex of sports and leisure uses energetic synergies; Nach dem Schwimmen geht's aufs Eis. Multifunktionaler Sport- und Freizeitkomplex nutzt energetische Synergien

    Energy Technology Data Exchange (ETDEWEB)

    Jaeger, Frank Peter [Redaktionbuero Archikontext, Berlin (Germany); Vonseelen, Tanja

    2012-11-01

    In Lentpark (Cologne, Federal Republic of Germany) skating and swimming are combined in one building - an unusual combination of use with tradition in Cologne. Recently the bureau Schulitz Architecture + Technology (Braunschweig, Federal Republic of Germany) designed the completed new building of the ice ring and swimming hall. The new building develops the energetic synergies of the coexistence of ice preparation and water heating. The new building was commissioned by KoelnBaeder GmbH (Cologne, Federal Republic of Germany) and is a unique of modern skating arena with spectacular ice overhead way, swimming pool and sauna in Europe.

  5. Der Umgang mit den beschlagnahmten Kunstwerken aus Schlössern des ehemaligen Herrscherhauses Habsburg-Lothringen. Ein Dilemma für die junge Tschechoslowakische Republik nach 1918

    Czech Academy of Sciences Publication Activity Database

    Uhlíková, Kristina

    2016-01-01

    Roč. 70, 1/2 (2016), s. 232-245 ISSN 0029-9626 Institutional support: RVO:68378033 Keywords : Archduke Franz Ferdinand d´Este * history of monument preservation * castles Subject RIV: AL - Art, Architecture, Cultural Heritage

  6. 1:0 for Spain. After the soccer World Championship, Spain won an important solar contest in South Africa; 1:0 fuer Spanien. Nach der Fussball-WM hat Spanien in Suedafrika nun einen wichtigen Solarwettbewerb gewonnen

    Energy Technology Data Exchange (ETDEWEB)

    Rosell, Alejandro Diego; Mattke, Sascha

    2012-03-15

    Spanish manufacturers acquired more orders for construction of industrial-scale PV systems in South Africa than their competitors from other countries. German manufacturers managed to get contracts as partners in several projects.

  7. Pulmonary radio-responses to surface field radiotherapy of Morbus Hodgkin using a 4 MeV linear accelerator. Die pulmonale Strahlenreaktion nach Mantelfeldbestrahlung mit einem 4 MeV-Linearbeschleuniger bei Morbus Hodgkin

    Energy Technology Data Exchange (ETDEWEB)

    Krueger, H.U.

    1982-05-05

    In 119 patients suffering from Morbus Hodgkin who were treated between 1974 and 1979, the pulmonary radio-response was retroperspectively investigated. Besides incidence and degree of severity, the course over the time of the individual stages of radio-response were also investigated. 14 patients showed no paramediastinal irradiation fibrosis as lasting stationary change, 52 showed a light one, 34 a medium-sized and 19 a severe one. Each fibrosis had been preceded by the radiomorphologic sign of pneumonitis of always the same degree of severity. The course over the time of the radiomorphologically subdivided stages determined that on the average the signs of a beginning pneumonitis occurred 11.6 weeks after onset of radiotherapy. An active pneumonitis was detectable after 14.8 weeks (on the average) and 20.4 weeks after radiotherapy had been started, a still florid pneumonitis with beginning shrinkage of the paramediastinal regions was found. The stage of stationary pulmonary fibrosis was reached 34.1 weeks (averaged value) after surface field irradiation had been started. Correlative relations to different individual disease-dependent and radiotherapeutic factors were detected, which are considered to be responsible for the intensity and character of the floride radio-response and the remaining pulmonary fibrosis. Considered from the radiomorphologic course of pulmonary irradiation reaction and its intensity and character, no significant advantage of tumor-reducing chemotherapy compared to irradiation or of split-course-technique compared to continuous fractioning was found. The introduction of individually adjustable shields helped to reduce the degree of severity of radio-response.

  8. Ergebnissse nach arthroskopisch assistiert durchgeführter vorderer Kreuzbandplastik mit Semitendinosussehne als Triple-Implantat in Single-Incision-Technik und femoraler Endobutton-Fixation : Nachuntersuchungen über einen Zeitraum von 1 Jahr

    OpenAIRE

    Seel, Matthias

    2004-01-01

    Das Ziel dieser Arbeit ist die Überprüfung des Stabilitätsgewinnes infolge einer operativen Therapie des rupturierten vorderen Kreuzbandes mit einer ipsilateralen autogenen, femoral mit einem Endobutton fixierten, Semitendinosussehne als Dreifachschlinge bei 103 Patienten, die in der Zeit vom Juli 1993 bis zum Januar 1995 an der Orthopädischen Klinik der Justus-Liebig-Universität in Gießen operiert wurden. Des weiteren sollten im Rahmen dieser Arbeit geschlechtsspezifische Unterschiede, Unter...

  9. Whole-body MR imaging in children with suspected osteonecrosis after intensive chemotherapy: preliminary results; Ganzkoerper-MRT bei Kindern mit Verdacht auf Osteonekrose nach intensiver Chemotherapie: Erste Ergebnisse

    Energy Technology Data Exchange (ETDEWEB)

    Beer, M.; Stenzel, M.; Darge, K. [Universitaetsklinikum Wuerzburg (Germany). Inst. fuer Roentgendiagnostik; Girschick, H.; Schlegel, P.G. [Universitaetsklinikum Wuerzburg (Germany). Kinderklinik

    2008-03-15

    Purpose: use of multidrug chemotherapy poses the risk of avascular osseous necroses in children. Depiction of the whole body, including clinically non-apparent sites is mandatory for starting early and proper treatment, including surgical approaches in lesions near the joints. We analyzed the value of whole-body MRI in the detection of osteonecrosis, (1) in relation to conventional X-ray imaging and clinical symptoms, (2) using different MRI sequences, (3) with follow-up examinations. Materials and methods: 5 patients suffering from an oncological disease, 13 to 16 years old (3 x ALL, 1 x medulloblastoma, 1 x CML), and recently developing bone pain were examined with X-ray imaging of the particular region and a whole-body MRI (T2w TIRM, T1w TSE sequences, pre- and post-contrast GD-DTPA, including fat suppression techniques). Neck/thorax/abdomen/pelvis, and upper and lower extremities were acquired in the coronal plane, and the feet in sagittal orientation. 4 of 5 patients had at least one follow-up examination (in the mean after 10 {+-} 4 months). Results: none of the initial X-ray images revealed an abnormal finding. The whole-body MRI showed in 4 of 5 children bone marrow lesions compatible with osteonecrosis. The locations were around the knee joints (n = 3) and the tibiae/ankle joints (n = 4). In addition to the symptomatic sites, MRI revealed additional lesions at the following sites: humerus (n = 5), hip joints (n = 4), knee joints (n = 6), ankle joints (n = 4). The size varied from small focal lesions to lesions measuring 90% of the whole transverse diameter of the bone. The lesions were able to be detected most easily with heavily T2-weighted (TIRM) sequences, and the diagnosis was most easily established using the non-enhanced TSE T1-weighted sequences. As a consequence of the results of the whole-body MRI, all patients with lesions compatible with osteonecrosis received symptomatic (n = 2) or specific (n = 2) therapy. In the follow-up examinations, a higher number of patients showed no changes in the lesions as to size and distribution. 2 patients showed partial resolution of the osteonecroses. (orig.)

  10. Exemption procedure for large-scale site rehabilitation projects as laid down in the administrative agreement on the financing of site rehabilitation in the New Laender; Altlastengrossprojekte im Freistellungsverfahren nach dem Verwaltungsabkommen zur Finanzierung der Altlastensanierung in den neuen Bundeslaendern

    Energy Technology Data Exchange (ETDEWEB)

    Hohenlohe, A zu; Kosinowski, M; Radtke, H

    1994-12-31

    The present article describes the legal groundwork of the Administrative Agreement on the Financing of Site Rehabilitation in the new Laender. It then lists 19 large-scale projects and depicts the organisational structure adopted for their implementation. Finally it presents various site rehabilitation concepts and financial schemes. (SR) [Deutsch] Der Artikel beschreibt die gesetzlichen Grundlagen des Verwaltungsabkommens zur Finanzierung der Altlastensanierung in den neuen Bundeslaendern. Anschliessend werden 19 Grossprojekte aufgelistet und die Organisationsstruktur zur Umsetzung der Sanierungsarbeiten dargestellt. Abschliessend werden Altlatensanierungskonzepte und Finanzrahmen dargestellt. (SR)

  11. Internet-Pranger auf Verdacht: Zur Bedeutung der Unschuldsvermutung für die Information der Öffentlichkeit über lebensmittelrechtliche Verstöße nach § 40 Abs. 1a Nr. 2 LFGB / Christoph Dannecker

    Index Scriptorium Estoniae

    Dannecker, Christoph

    2013-01-01

    Avalikkuse teavitamisest toiduainetega seotud seaduserikkumistest toiduaineteseaduse (Lebensmittel-, Bedarfsgegenstände- und Futtermittelgesetzbuch) § 40 lõige 1a tähenduses, mis sätestab, et avalikkust teavitab pädev asutus

  12. Die Macht des geografischen Raums – Auch nach gut hundert Jahren sind Halford J. Mackinders Aussagen zum „geografischen Drehpunkt der Geschichte“ von überraschend politischer Relevanz

    Directory of Open Access Journals (Sweden)

    Maresch, Rudolf

    2010-12-01

    Full Text Available The English geographer Sir Halford Mackinder ended his famous 1904 article, “The Geographical Pivot of History,” with a disturbing reference to China. He posited that the Chinese, should they expand their power well beyond their borders, “might constitute the yellow peril to the world’s freedom.” Leaving aside the sentiment’s racism, which was common for the era, nearly a hundred years ago Mackinder’s statement gives us a surprising view of enormous political actuality in geopolitics, which was denied for a couple of decades in Western Europe, especially in Germany.

  13. Textkritische Edition der Übersetzung des Psalters in die Litauische Sprache von Johannes Bretke, Pastor zu Labiau und Königsberg i. Pr., nach der Handschrift aus dem Jahre 1580 [...

    OpenAIRE

    Gelumbeckaitė, Jolanta

    2003-01-01

    The review discusses the historical critical edition of the Psalm Book translated into Lithuanian by Jonas Bretkūnas in 1580 prepared by Friedrich Scholz, Professor Emeritus at Münster University. This is the first textologically diplomatically in corpore published volume of the Bible manuscript by Bretkūnas (1579–1590) and the first critical edition of the 16th c. Lithuanian manuscript text. The critical edition of the Psalm Book is part of a large Bretkūnas’ Bible publishing project, consis...

  14. Fluorescence microscopical studies on chitin distribution in the cell wall of giant cells of Saccharomyces uvarum, grown following X-radiaiton treatment. Fluoreszenzmikroskopische Untersuchungen zur Chitinverteilung in der Zellwand von Riesenzellen von Saccharomyces uvarum, gewachsen nach Roentgenbestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Hoschka, L

    1982-01-01

    Teast cells are synchronized and modiated with X-rays (1.0 kGy) in the Cr, phase. Their growth behaviour is observed in suspension cultures and the formation of giant cells noted. The chitin structures are selectively stained with the fluorescent dye Calcofluor white. In the unradiated cells the chitin is deposited at the bud constriction site in the form of rings in the mother cell wall, whereas for irradiated cells only one chitin ring of normal appearance is formed between the mother cell and first bud equivalent. Between further bud equivalents an intensification of fluorescence is occasionally noted, however the organisation of the chitin into a regular ring arrangement is disturbed. In giant cells the facility for primary and secondary septa formation is missing and these are essential for successful cell division. By further experiments it was possible to identify the cause of disturbance in the cell cycle of irradiated cells. Giant cells only form one chitin ring because its DNA is replicated one time only. The major cause triggering the actual formation of giant cells must be considered the missing distribution of the once-rephicated DNA. All processes in the cell cycle dependent on this step are therefore stopped and only bud formation which occurs independently continues along its rhytmical path.

  15. Fluorescence microscopical studies on chitin distribution in the cell wall of giant cells of Saccharomyces uvarum, grown following X-radiation treatment. Fluoreszenzmikroskopische Untersuchungen zur Chitinverteilung in der Zellwand von Riesenzellen von Saccharomyces uvarum, gewachsen nach Roentgenbestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Hoschka, L

    1982-01-01

    Yeast cells are synchronized and modiated with X-rays (1.0 kGy) in the Cr, phase. Their growth behaviour is observed in suspension cultures and the formation of giant cells noted. The chitin structures are selectively stained with the fluorescent dye Calcofluor white. In the unradiated cells the chitin is deposited at the bud constriction site in the form of rings in the mother cell wall, whereas for irradiated cells only one chitin ring of normal appearance is formed between the mother cell and first bud equivalent. Between further bud equivalents an intensification of fluorescence is occasionally noted, however the organisation of the chitin into a regular ring arrangement is disturbed. In giant cells the facility for primary and secondary septa formation is missing and these are essential for successful cell division. By further experiments it was possible to identify the cause of disturbance in the cell cycle of irradiated cells. Giant cells only form one chitin ring because its DNA is replicated one time only. The major cause triggering the actual formation of giant cells must be considered the missing distribution of the once-rephicated DNA. All processes in the cell cycle dependent on this step are therefore stopped and only bud formation which occurs independently continues along its rhythmical path.

  16. Good neighborhood in a crisis? Germans and French in search of a common energy policy (1973 - 1980); Stoerfall fuer die gute Nachbarschaft? Deutsche und Franzosen auf der Suche nach einer gemeinsamen Energiepolitik (1973-1980)

    Energy Technology Data Exchange (ETDEWEB)

    Tauer, Sandra

    2012-11-01

    The oil crisis of autumn 1973 was a turning point of the seventies. Citizens of industrialized countries were brought to realize their dependence on Arab imported oil the hard way. Using the example of German-French relations, the author investigates if there were instances of cooperation in energy policy, and in what concrete manner. Using historical primary energy sources, she starts by investigating the actions and political strategies of the German and French governments and also describes the search for multilateral solutions. Examples are presented to show how civil society is affected. This first systematic analysis of German-French relations shows that energy policy had great importance for the bilateral relation even though results of German-French cooperation were few and far between.

  17. Ventilation components according to DIN 1946-6. Messages from the C.A.T.S. Academy; Lueftungskomponenten nach DIN 1946-6. Mitteilungen aus der C.A.T.S.-Academy

    Energy Technology Data Exchange (ETDEWEB)

    Nadler, Norbert [CSE Nadler, Oranienburg (Germany)

    2011-07-01

    On the one hand, the buildings are performed tightly according to the building regulations, on the other hand a minimum of air change is to be ensured. The former demand for air change by manual opening of the windows is no longer accepted. The calculation method of the regulation DIN 1946-6 enables both the establishment of a ventilation concept as well as an interpretation of the ventilation components. A critical evaluation of the regulation and the demands of practice result in necessary amendments which result in requirements of the appropriate software. The implementation of these requirements exemplary is demonstrated on the basis od the new C.A.T.S. ventilation.

  18. Cuts in energy and operating cost with the Swiss system 'Energie in ARA' - practical experience in Germany; Energie- und Betriebskosteneinsparungen nach dem schweizerischen System ''Energie in ARA'' - Praxiserfahrungen in Deutschland

    Energy Technology Data Exchange (ETDEWEB)

    Christmann, B. [UmBAUwelt Partnerschaft Architekten und Ingenieure, Riedstadt (Germany)

    1999-07-01

    German sewage treatment plants, too, have potential for saving energy cost and cutting down on their operating expenditure. Following the systematy developed by the 'Energie in ARA' concept, this potential can be harnessed. (orig.) [German] Potential fuer Energiekosteneinsparungen und dadurch initiierte Betriebskosteneinsparungen ist auch bei deutschen Klaeranlagen vorhanden. Die Systematik 'Energie in ARA' kann fuer die Erschliessung der Einsparpotentiale verwendet werden. (orig.)

  19. Acute and chronic gastric emptying disorders in rats after localized X-irradiation, and the therapy of these disorders. Akute und chronische Stoerungen in der Magenentleerung nach Roentgenbestrahlung des Rattenmagens und deren therapeutische Beeinflussbarkeit

    Energy Technology Data Exchange (ETDEWEB)

    Breiter, N.; Sassy, T. (GSF, Inst. fuer Strahlenbiologie, Neuherberg (Germany) Muenchen Univ. (Germany). Strahlenbiologisches Inst.); Trott, K.R. (St. Bartholomew' s Medical Coll., Dept. of Radiation Biology, London (United Kingdom))

    1992-07-01

    After localized 300 kV X-irradiation of the rat stomach the stomach emptying time of a liquid and a solid test meal was examined with a non-invasive radiological method. In the acute period one to three weeks after irradiation with single doses between 10.7 and 21.3 Gy we observed a faster emptying of the liquid and a delayed emptying of the solid test meal. The faster emptying of the liquid test meal was treated successfully with atropin. In the chromic period we observed a delayed emptying of the liquid and of the solid test meal. These emptying disorders were treated partially successfully with the parasympathomimeticum carbachol and they were treated completeley successfully with the dopamine antagonist metoclopramide. (orig.).

  20. Monitoring of dams according to German standard DIN 19 700 on the basis of a GIS based expert system; Stauanlagenueberwachung nach DIN 19 700 in Verbindung mit Expertensystemen auf GIS-Basis

    Energy Technology Data Exchange (ETDEWEB)

    Kast, Karl; Saucke, Ulrich; Elsaesser, Ralph [Dr.-Ing. Karl Kast + Partner (GbR) Ingenieurgemeinschaft fuer Umwelt- und Geotechnik, Ettlingen (Germany)

    2010-07-01

    The German standard DIN 19 700 stipulates regular safety reports assessing dams and their operation as part of the continuous dam monitoring scheme. Experience has shown that a GIS based dam monitoring system exhibits evident advantages regarding a continuous assessment. Besides and easy access to all relevant information grouped by themes, it offers a graphic analysis of measuring data and their display in the GIS system. In addition, concerning relevant failure mechanism, individual modules of a GIS based expert system are designed for the purpose of assessing the safety of the dam in the event of uncommon incidents. (orig.)

  1. Owners responsibility of refrigeration equipment according F-Gas-regulation 'EC 842/2006' and answers; Betreiberpflichten nach 'F-Gas-Verordnung' EG 842/2006 und Antworten darauf

    Energy Technology Data Exchange (ETDEWEB)

    Beermann, Karsten [IKKE gGmbH, Duisburg (Germany)

    2012-08-15

    The results of the F-Gas-regulation EC 842/2006 are some responsibilities for owners of refrigeration equipment. To fulfill these duties exist e-learning training modules and different tools which are the result of a European LEONARDO- project. Particularly the awareness of the equipment owner and the certified person (refrigeration technician) according the regulation will be the main background of a safe handling of refrigerants for an effective environmental protection. Interested persons and companies will find helpful information to learn good practice. (orig.)

  2. Energy policy in Germany upon Fukushima. The impact of the nuclear accident on the German energy policy; Energiepolitik in Deutschland nach Fukushima. Der Einfluss des Atomungluecks auf die deutsche Energiepolitik

    Energy Technology Data Exchange (ETDEWEB)

    Wellnhofer, Martin

    2012-11-01

    The author of the book under consideration analyzes the media reports of the daily newspapers ''Frankfurter Allgemeine Zeitung'', ''Sueddeutsche Zeitung'' and ''Die Zeit'' with respect to the influence of the nuclear accident in Fukushima on the German energy policy. The author examines the background to the current energy policy debate. A holistic approach is used to understand the political decisions. The holistic approach describes the energy policy discourse since the beginning of the planned nuclear phase-out in the year 1998. Thus, the holistic approach is a prerequisite for a comparative analysis of the discourses.

  3. Hemangiosarcoma after breast-conserving therapy of breast cancer. Report of four cases with molecular genetic diagnosis and literature review; Haemangiosarkom nach brusterhaltender Therapie beim Mammakarzinom. Vier Fallbeispiele mit molekulargenetischer Diagnostik und Literaturuebersicht

    Energy Technology Data Exchange (ETDEWEB)

    Nestle-Kraemling, Carolin [Universitaetsklinikum, Duesseldorf (Germany). Frauenklinik; Boelke, Edwin; Budach, Wilfried [Universitaetsklinikum Duesseldorf (DE). Klinik und Poliklinik fuer Strahlentherapie und radiologische Onkologie] (and others)

    2011-10-15

    Hemangiosarcomas of the breast represent a rare disease of the breast mainly occurring as secondary neoplasias with a latency of 5-10 years after primary treatment of breast cancer and are associated with an unfavourable prognosis. Radiation therapy, which is integrated within the concept of breast conserving therapy ranks as the main risk factor. In this report we describe the clinical course of 4 patients including their molecular genetic pattern and give a summary of the actual literature. Hemangiosarcomas occur as a secondary neoplasm with a latency of 5-10 years after primary treatment of breast cancer and have an unfavorable prognosis. A genetic predisposition is assumed, but we could not find a significant role of tumor suppressor genes BRCA1, BRCA2 or p53 in our patients. Due to limited data available for these tumors, recommendations for therapy include radical tumor resection achieving wide free margins and inconsistent regimens of chemo- and/or immunetherapy modalities. In the majority these are based on systemic therapy regimens for other cutaneous sarcomas, such as Kaposi's sarcoma. Efforts should be taken for a nation-wide systematic registration of all cases of post-irradiation hemangiosarcomas.

  4. Retinoic Acid for High-risk Neuroblastoma Patients after Autologous Stem Cell Transplantation - Cochrane Review Retinsäure nach erfolgter autologer Stammzelltransplantation bei Hochrisiko-Patienten mit Neuroblastom - Cochrane Review

    NARCIS (Netherlands)

    Peinemann, F.; van Dalen, E. C.; Berthold, F.

    2016-01-01

    Neuroblastoma is a rare malignant disease and patients with high-risk neuroblastoma have a poor prognosis. Retinoic acid has been shown to inhibit growth of human neuroblastoma cells and has been considered as a potential candidate for improving the outcome. The objective was to evaluate effects of

  5. Implementation of standards at a research institute. Storage and keeping of radioactive materials following DIN 25422; Umsetzung von Normen in einem Forschungsinstitut. Sichere Aufbewahrung und Lagerung radioaktiver Stoffe nach DIN 25422

    Energy Technology Data Exchange (ETDEWEB)

    Koeble, T.; Weinand, U. [Fraunhofer-INT, Euskirchen (Germany)

    2016-07-01

    The secure storage and keeping of radioactive materials is increasingly important especially in times of a growing threat by terrorists. Authorities and users are jointly recommended to adapt the storage and keeping of radioactive materials to increasing security requirements. Here the different possibilities to fulfil the requirements regarding fire prevention and theft prevention which in Germany are set by DIN 25422 were determined for the radioactive materials and their storage and keeping places present in a research institute. The required measures were than agreed about with the relevant authority. Difficulties which are occurring due to the demanding combination of requirements out of the areas of radiation protection, fire prevention, and theft prevention are discussed. The storage and keeping of radioactive materials especially such of high activity requires a high level of security which must be continuously adapted to rising requirements.

  6. Cathodic corrosion protection in jacket tube steel pipes. Practical experience after five years of operation, a summary; Kathodischer Korrosionsschutz von Stahlrohrleitungen in Mantelrohren. Praxishinweise nach 5 Jahren - eine Zusammenfassung

    Energy Technology Data Exchange (ETDEWEB)

    Lemkemeyer, Marc [RWE Westfalen-Weser-Ems Netz-service GmbH, Dortmund (Germany)

    2011-07-01

    In november 2006, the completely revised AfK recommendation No. 1 came into force. It was the first of its kind to contain concrete calculation methods for calculating the effects of cathodic corrosion protection in jacket tubes. In the five years that followed, a large number of jacket tubes was investigated by this method. It was found that some input parameters that are only estimated still require further specification. Further, some further calculation algorithms have been defined. Some of the specifications are described in more detail in this article.

  7. Hunger for carbon dioxide. Foundation of the 'Task Force Biomass' for the development of new energy sources; Hunger nach Kohlendioxid. 'Task Force Biomasse' zur Erschliessung neuer Energiequellen gegruendet

    Energy Technology Data Exchange (ETDEWEB)

    Schlaefer, Susanne; Bayer, Thomas [Infraserv GmbH und Co. Hoechst KG, Frankfurt am Main (Germany)

    2009-10-15

    At the industrial park Hoechst (Frankfurt / Main, Federal Republic of Germany), Infraserv GmbH and Co. Hoechst KG pursues the disposal conception ''Waste to Energy'' in order to supply electricity and steam for the approximately 90 producing companies at the location. The company now looks for possibilities in order to develop new energy sources. The keyword is ''innovative biomass''. Among other things the possibility of power generation from algae belongs to this.

  8. Contribution to the U$_2$C$_3$ formation by the synthetic reaction and by the decomposition of UC$_2$; Beitrag zur U$_2$C$_3$-bildung nach der synthetischen reaktion und durch zerfall von UC$_2$

    Energy Technology Data Exchange (ETDEWEB)

    Buschinelli, A. J.A.

    1974-06-01

    This work is a contribution to the study of the mechanism and of the kinetics of the U$_2$C$_3$ formation by the synthetic reaction. The influences of a mechanical and a thermical pre-treatment of the samples on the reaction kinetics were investigated and discussed taking into account other information from the literature. The relative increasing of the U$_2$C$_3$ nucleation rate due to the pulverization corresponds approximately to the surface enlargement of the pulverized material. The activation energy for the synthetic reaction in powder was found to be 94 +- 7 kcal/mol. The negative influence of nitrogen, oxygen and tungsten on the U$_2$C$_3$ formation was reported. In the decomposition of UC$_2$ to U$_2$C$_3$ and graphite, the influences of the morphology of the graphite precipitate and the fast neutron irradiation on the beginning of the U$_2$C$_3$ formation were also investigated.

  9. Disposal of residues according paragraph 97 StrlSchV - Efficient self control and handling of applications for release from regulatory control; Entsorgung von Rueckstaenden nach paragraph 97 StrlSchV - effektive Selbstueberwachung und Bearbeitung von Entlassungsverfahren

    Energy Technology Data Exchange (ETDEWEB)

    Gellermann, R. [HGN Hydrogeologie GmbH, Braunschweig (Germany)

    2005-07-01

    To control residues according to paragraph 97 of the German Radiation Protection Ordinance (StrlSchV), the ordinance earmarks a self - control of involved companies in the case of very low specific activities, an authorisation of release from regulatory control to disposal in the case of higher specific activities and a balancing of disposed activities in the case of large amounts. The realisation of this regulation requires the exchange of information between owners of residues, disposing companies and authorities. In order to make this information available and controllable in an efficient way, a well structured system of documents was developed analogue to an existing system in waste management. Practical experiences with this system are discussed. (orig.)

  10. Modeling of DNA damage-cluster, cell-cycle and repair pathway dependent radiosensitivity after low- and high-LET irradiation; Modellierung der DNA-Schadenscluster-, Zellzyklus- und Reparaturweg-abhaengigen Strahlenempfindlichkeit nach niedrig- und hoch-LET-Bestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Guenther, Paul

    2017-07-17

    This work focuses on modeling of the effects of ionizing radiation on cells, primarily on, the influence of the DNA repair pathway availability and the radiation quality on the cell-survival probability. The availability of DNA repair pathways depends on the replication state and defects of the DNA repair pathways. The radiation quality manifests itself in the microscopic ionization pattern. The Giant LOop Binary LEsion (GLOBLE) model and the Local Effect Model (LEM) describe the cell-survival after photon and ion irradiation, respectively. Both models assume that cell survival can be modeled based on the spatial distribution of Double-Strand Breaks (DSB) of the DNA (damage pattern), within a higher order chromatin structure. Single DSB are referred to as isolated DSB (iDSB) and two or more DSB in close proximity (within 540 nm) are called complex DSB (cDSB). In order to predict the cell-survival, the GLOBLE-Model considers different iDSB repair-pathways and their availability. One central assumption of the LEM is that the same damage patterns imply same effects, regardless of the radiation quality. In order to predict the damage pattern the microscopic local dose distribution of ions, described by the amorphous track structure, is evaluated. The cell survival after ion irradiation is predicted from a comparison with corresponding damage patterns after photon irradiation. The cell-survival curves after high dose photon irradiation cannot be predicted from the Linear Quadratic (LQ) Model due to their transition towards a linear dose dependence. This work uses the GLOBLE-Model to introduce a novel mechanistic approach, which allows the threshold dose to be predicted for the transition from a linear quadratic dose dependence, of survival curves at low doses, to a linear dose dependence at high doses. Furthermore, a method is presented, which allows LEM to predict the survival of synchronous cells after ion irradiation based on the cell survival after photon irradiation. This method is able to qualitatively predict the influence of the cell-cycle and the radiation quality on radiosensitivity. Based on this, two approaches for the LEM prediction of the Relative Biological Effectiveness (RBE) are compared. The first approach predicts the RBE based on the survival of asynchronous cells. The second approach predicts the RBE from the sum of survival curves of the subpopulations, which contribute to the asynchronous cell population. Both approaches lead to qualitatively similar results. In the context of describing the microscopic dose deposition of ion irradiation by the amorphous track structure, two questions are addressed: 1. Is it possible to improve the prediction of cell survival after ion irradiation by a more sophisticated composition of the direct and indirect effect? 2. is the amorphous track structure an appropriate model of the dose deposition regarding the DNA damage clustering on the nm-scale or is it necessary to evaluate single ionizations on the molecular level? Regarding the first question, it is shown that a more detailed evaluation of the direct and indirect effect improves the agreement of the LEM predictions to data. Concerning the second question, it is shown that the amorphous track structure can be used for the prediction of DNA damage induction on the nm-scale similar to an ab initio Monte Carlo simulation. In the context of cell-survival modeling, the relevant length scale for DNA damage-clustering is often discussed. The iDSBs und cDSBs used in the GLOBLE and LEM are referring to DNA damage clustering on the μm-scale. There are also models which predict the cell survival after ion irradiation based on complex DNA-damage-clusters on the nm-scale. This work shows, that complex DNA damage-clusters on the μm-scale are correlated to damage clusters on the nm-scale. Therefore, it is possible to predict the cell survival after ion irradiation based on both scales. However, the cell survival after photon irradiation cannot be predicted based on damage-clusters on the nm-scale.

  11. 15 years return transport of vitrified high-level waste from France. The long way from La Hague to Gorleben; 15 Jahre Rueckfuehrung von verglasten hochaktiven Abfaellen aus Frankreich. Der lange Weg von La Hague nach Gorleben

    Energy Technology Data Exchange (ETDEWEB)

    Horn, Thomas [GNS Gesellschaft fuer Nuklear Service mbH, Essen (Germany)

    2012-11-01

    The operators of German nuclear power plants have contracts since 1977 with the French company AREVA NC (former COGEMA) and since 1980 with the British company NDA (former BNFL) for reprocessing of spent nuclear fuel. Since July 2005 the delivery of irradiated fuel element into a reprocessing plant is prohibited. Until 2005 fuel elements with about 6.080 tSM were shipped abroad, about 5.309 tSM to France. The contribution deals with the history of the transports from La Hague to Gorleben, including the contamination problems in 1988 that caused restrictions by the German authorities. A catalogue of safety requirements had to be fulfilled for the allowance of further return transports. The development of appropriate transport casks to cope with changing heat generation of the high-level waste is described. During the complete transport cycle extensive radiological measurements were performed. By the end of 2011 the HAW (high-level waste) glass coquilles were completely returned to Gorleben.

  12. Processes for exhaust purification of biomass combustion systems, dust removal, heat recovery, technologies and practical experience; Verfahren zur Abgasreinigung nach Biomasseverbrennung, Abgasentstaubung, Abgasreinigung Moeglichkeiten zur Waermerueckgewinnung; Technologien und Praxiserfahrungen

    Energy Technology Data Exchange (ETDEWEB)

    Jirkowsky, C.; Pretzl, R.; Sihorsch, K.

    2003-07-01

    The authors report on air pollution control systems of biomass burners: dedusting, centrifugal filtration, cyclone separators, electric filters (wet and dry), fabric filters, wet scrubbers. Technical specifications and methods of heat recovery are given. (uke)

  13. Recognized and new problems of power generation from waste wood according to the new EEG of 2004; Alte und neue Probleme der Altholzverstromung nach der EEG-Novelle 2004

    Energy Technology Data Exchange (ETDEWEB)

    Anger, C. [Avocado Rechtsanwaelte, Koeln (Germany)

    2005-10-01

    Power generation from waste wood according to the EEG (Renewables Act), even in the modified version of 2004, raises complex legal problems under EU law. The contribution discusses these problems and presents important information on the legal boundary conditions of power generation from waste wood. (orig.)

  14. If science does create more than knowledge. A congress is asking for 'education by science'; Wenn Wissenschaft mehr als Wissen schafft. Ein Kongress fragt nach 'Bildung durch Wissenschaft'

    Energy Technology Data Exchange (ETDEWEB)

    Nuissl, E. (ed.)

    2002-07-01

    The role of science in the development of the so-called 'knowledge society' was investigated at this interdisciplinary congress. Three problem areas were identified: 1. Science itself must constantly review its own ethical fundamentals and investigate and extend its ability to keep a dialogue running. 2. Society is asked to provide an ethical and moral orientation for dealing with newly acquired knowledge and to define the social standing of science. 3. Each and every individual must work on maintaining and extending his or her level of knowledge in order to cope with everyday life and perform social functions. [German] Ziel des Kongresses ''Bildung durch Wissenschaft'' war es, im interdisziplinaeren Austausch die Rolle der Wissenschaft bei der Entwicklung der so genannten ''Wissensgesellschaft'' zu eroertern. Der enorme Wissenszuwachs des vergangenen Jahrhunderts bedeutet eine Zunahme des ''Machbaren'', von dessen positiven wie negativen Folgen die Gesellschaft und der Einzelne gleichermassen betroffen ist. Das gilt gerade fuer diejenigen Technologien und Wissensbestaende, die im Alltag von Bedeutung sind. Der Kongress beschaeftigte sich mit diesen Entwicklungen und mit den Problemen, die sich daraus ergeben. Der erste Problemkreis betrifft die Wissenschaft selbst: Sie muss sich ihrer eigenen ethischen Grundlagen wieder neu vergewissern, ihre Dialogfaehigkeit ueberpruefen und erweitern. Ein zweiter Problemkreis ist auf Seiten der Oeffentlichkeit auszumachen: Die Gesellschaft wird ethische und moralische Orientierungen fuer den Umgang mit dem neu erworbenen Wissen schaffen und grundsaetzlich den gesellschaftlichen Stellenwert der Wissenschaft bestimmen muessen. Der dritte Problemkreis stellt sich dem Einzelnen: Jeder ist gefordert, kontinuierlich sein Wissensniveau zu erhalten und zu erweitern, um den Alltag bewaeltigen und gesellschaftliche Aufgaben wahrnehmen zu koennen. (orig.)

  15. A new subsidy regulation for coal after 2002 on the basis of the EC treaty; Eine neue Beihilferegelung fuer die Steinkohle nach dem Jahr 2002 auf der Basis des EG-Vertrags

    Energy Technology Data Exchange (ETDEWEB)

    Reichel, W. [Gesamtverband des Deutschen Steinkohlenbergbaus, Essen (Germany)

    2000-08-10

    Coal is and will remain the most important indigenous energy resource in Europe. Hence, an appropriate ECSC regulation must be drawn up for coal subsidies in the EC Treaty after 2002 to enable a core mining industry based on the long-term safeguarding of supply. This is primarily not a legal, but a political question. Neither Kyoto nor the expansion of natural gas or image problems militate against coal. Its future contribution to the energy mix requires above all advances in technology. (orig.) [German] Die Kohle ist und bleibt die wichtigste heimische Energieressource Europas. Fuer die Kohlenbeihilfen muss daher ab dem Jahr 2002 eine adaequate EGKS-Nachfolgeregelung im Rahmen des EG-Vertrags getroffen werden, um einen mit der langfristigen Versorgungssicherung begruendeten Kernbergbau zu ermoeglichen. Dies ist primaer keine rechtliche, sondern eine politische Frage. Weder Kyoto noch die Erdgasexpansion oder Imageprobleme sprechen grundsaetzlich gegen die Kohle. Ihr zukuenftiger Beitrag zum Energiemix erfordert vor allem eine Technikoffensive. (orig.)

  16. Risk of somatic late effects in man following incorporation of /sup 224/Ra(thorium X). Risiko somatischer Strahlenspaetschaeden des Menschen nach Inkorporation von /sup 224/Ra(Thorium X)

    Energy Technology Data Exchange (ETDEWEB)

    Wick, R.R.; Chmelevsky, D.

    1986-03-01

    1568 ankylosing spondylitis patients, injected with repeated injections of /sup 224/Ra for treatment of their disease, have been observed in the GSF (study II). By the end of 1985 3 cases of malignant tumours in the skeleton had been observed, compared to 0 cases in a control group. According to the cancer mortality statistics for the FRG the age-corrected number of spontaneous bone tumours expected would be 0.4-0.7. In contrast, a recent risk estimate from the data of the patient group of study I (SPIESS/MAYS) who were treated with considerably higher doses, suggests an expected number of 5.8 radiation induced bone tumours for the present follow-up tine. Latest observations from that group show that bone tumours may occur up to 33 yr after treatment with /sup 224/Ra. Thus, the possibility of additional cases of bone tumours occurring in study II cannot be excluded. One striking observation was that 2 of the 3 skeletal tumours observed in study II were tumours of the bone marrow; there has been only 1 bone marrow tumour in the high dose group (study I) among 56 bone tumours. In addition there have been 6 and 5 leukaemias in the exposure and control group respectively. Of the 6 leukaemias in the exposure group 3 were chronic myeloid leukaemias (CML), whereas among the 5 leukaemias in the control group there was no CML.

  17. Long-term investigation of the risk of malignant diseases following intravenous radium-224 treatment for ankylosing spondylitis; Langzeituntersuchung zum Risiko maligner Erkrankungen nach intravenoeser Behandlung des Morbus Bechterew mit Radium-224

    Energy Technology Data Exchange (ETDEWEB)

    Schulte, Tobias L. [Klinik und Poliklinik fuer Allgemeine Orthopaedie und Tumororthopaedie, Universitaetsklinikum Muenster (Germany); Nekolla, Elke A. [Bundesamt fuer Strahlenschutz (BfS), Neuherberg (Germany); Wick, Roland R. [Inst. fuer Strahlenbiologie, Helmholtz-Zentrum Muenchen, Deutsches Forschungszentrum fuer Gesundheit und Umwelt, Neuherberg (Germany)

    2009-09-15

    Background and purpose: in German-speaking countries, the intravenous treatment of ankylosing spondylitis (AS) with radium-224 ({sup 224}Ra) was common between the late 1940s and 2005. In this long-term investigation, the risk of malignant diseases following intravenous {sup 224}Ra treatment for AS was assessed. Patients and methods: in a prospective long-term study, 1,471 patients with AS who were treated with {sup 224}Ra between 1948 and 1975 have been followed together with a control group of 1,324 AS patients treated neither with radioactive drugs nor with X-rays. Standardized questionnaires to evaluate the patients' health status were used. Observed numbers of malignant diseases were compared with those of the control group as well as with expected numbers for a normal population. Results: After 26 years of follow-up, causes of death have been certified for 1,006 patients of the exposure group (control group: 1,072 patients). Significantly increased rates of myeloid leukemia (12 cases observed vs. 2.9 expected; p < 0.001), kidney cancer (18 vs. 9.1; p < 0.01), thyroid cancer (4 vs. 1.2; p = 0.03) and borderline significantly increased rates of cancer of female genital organs (10 vs. 5.6; p = 0.06) were found in the exposure group in contrast to no significant increases of these diseases in the control group. Rates of pulmonary and gastrointestinal malignancies were not increased. Lymphatic leukemia (exposure group: 8 vs. 2.7; p < 0.01; control group: 7 vs. 3; p = 0.03) was significantly elevated due to a high rate of chronic lymphatic leukemia in both, the exposure as well as the control group. Conclusion: treatment of AS with {sup 224}Ra led to increased incidences of myeloid leukemia and malignancies of kidneys, thyroid and female genital organs. Although this kind of therapy is now abandoned, there is a need for close follow-up of patients who received it. (orig.)

  18. Atmospheric transport modelling for the CTBT radionuclide network in routine operation and after the Fukushima releases; Atmosphaerische Transportmodellierung fuer das Radionuklidmessnetz zur Ueberwachung des Kernwaffenteststoppvertrages im Regelbetrieb und nach den Freisetzungen in Fukushima

    Energy Technology Data Exchange (ETDEWEB)

    Ross, J.O.; Ceranna, L.; Boennemann, C. [Bundesanstalt fuer Geowissenschaften und Rohstoffe (BGR), Hannover (Germany). B4.3; Schlosser, C. [Bundesamt fuer Strahlenschutz (BfS), Freiburg (Germany). SW2.5

    2014-01-20

    The Comprehensive Nuclear-Test-Ban Treaty (CTBT) bans all types of nuclear explosions. For verification of compliance with Treaty the International Monitoring System (IMS) is being built up by the Provisional Technical Secretariat (PTS) of the CTBT-Organisation in Vienna. The IMS observes waveform signals (seismic, infrasound, hydroacoustic) of explosions and traces of radionuclides in the atmosphere to proof the nuclear character of an event. The International Data Centre (IDC) provides analysis products for the IMS data such as various event bulletins, radionuclide reports, and atmospheric transport modeling (ATM) results confining the possible source region of detected radionuclides. The judgment on the character of a suspicious event remains with the member states. The German National Data Centre for verification of CTBT is hosted by the Federal Institute for Geosciences and Natural Resources (BGR) in Hannover. The BGR operates four IMS stations (IS26, IS27, PS19, and AS35) and cooperates closely with the Federal Office for Radiation Protection (BfS) who operates the radionuclide station RN33 at mount Schauinsland and supports the NDC with radionuclide expertise. In response to the Fukushima accident caused by the large magnitude 9.0 Tohuku Earthquake and Tsunami the HSYSPLIT model driven by 0.5 degree NCEP data was used at the German NDC to simulate the primary transport pathways of potentially emitted radioisotopes. The analysis focuses on arrival times and dilution ratios at the radionuclide stations of the IMS. The arrival times were predicted correctly at most stations for ten days after the accident. Traces of the Fukushima emissions were detected at all IMS radionuclide stations on the Northern Hemisphere end of March. In April also some stations on the Southern Hemisphere detected some traces which passed the ITCZ. In respect to the CTBT context the influence of the Tohoku earthquake and the Fukushima emissions on the network capability to detect a clandestine nuclear test of the DPRK in March 2011 was investigated. Furthermore detections which are possibly connected with the recent nuclear test of the DPRK on 12 February 2013 are discussed. The potential range for radioxenon emissions is assessed by atmospheric transport modeling. It is found that the gaseous fission products were contained better than 99.9% in the first weeks after the explosion.

  19. Boilers after 30 years. State of the art. Pt. 1. From the use of calorific value to the boiler; Brennwertkessel nach 30 Jahren. Stand der Technik. T. 1. Von der Brennwertnutzung zum Brennwertkessel

    Energy Technology Data Exchange (ETDEWEB)

    Kremer, Robert [Deutscher Verein des Gas- und Wasserfaches e.V. (DVGW) (Germany). Fachausschuss Trinkwasserhygiene in Gebaeuden; Selbach, Juergen

    2009-01-15

    The economical extent with raw materials and other materials as well as the effective utilization of materials in production processes compellingly is necessary for economy reasons in all industrial industries and handicraft industries. In the case of the consumption of thermal energy, also today still amazing possibilities of energy conservation result. Boilers with which the upper calorific value of fuels can be used are well-known for 30 years but not yet sufficiently spread. One of the calorific value pioneers had to announce insolvency in the year 2000. Today one endeavoured with modern boilers to realize the technically possible and economically necessary annual consumption index of approximately 100 % in practice.

  20. The Commitment decision according to paragraph 29 EnWG - a standardizing regulation under the supervision of the courts; Die Festlegungsentscheidung nach paragraph 29 EnWG - normierende Regulierung unter den Augen der Gerichte

    Energy Technology Data Exchange (ETDEWEB)

    Attendorn, Thorsten [Bezirksregierung Arnsberg (Germany)

    2009-03-15

    With the commitment decision according to paragraph 29 Energy Economy Act, the regulation authority has an effective instrument, which enables a one-sided determination of the entrance conditions and entrance methods as well as tariffs. This is an application of the standardizing regulation. The desired result is not caused ex post, but ex-ante. This is due to a uniform decision instead of a multiplicity of abuse decisions. The first commitment decisions passed the court instances. In the meantime, there are several decisions of the higher regional court and the Federal High Court. That gives cause to a stock-taking. The author of the contribution under consideration reports on this stock-tacking.

  1. Monte Carlo simulations to calculate energy doses in a cow after continuous ingestion of CS 137 and K 40; Monte-Carlo-Simulationen zur Berechnung der Energiedosis in einem Rind nach kontinuierlicher Aufnahme von CS 137 und K 40

    Energy Technology Data Exchange (ETDEWEB)

    Pichl, E. [Technische Univ. Graz (Austria). Inst. fuer Medizintechnik; Rabitsch, H. [Technische Univ. Graz (Austria). Arbeitsgebiet Strahlenphysik

    2009-07-01

    Currently ICRP (International Commission on Radiological Protection) develops a new recommendation to estimate the natural radiation exposure of an agreed set of animals and reference plants. For estimating effective dose in humans and animals, the incorporated activities of natural and artificial radionuclides in body tissues and contents of the digestive system have to be known. It was the aim of this investigation to calculate energy doses caused by Cs 137 and K 40 in the reproductive organs (uterus, ovaries) of a cow. During its whole lifetime from 1986 to 1992, the cow incorporated continuously Cs 137 which was due to the fallout following the Chernobyl accident. K 40 occurs naturally in the cow's fodder. The cow was born in a highly contaminated region of Styria, Austria, and was infertile since 1990. The activities of Cs 137 and K 40 in the cow's fodder and in tissues, organs and contents of the digestive system of the carcass were measured simultaneously with the help of semiconductor detectors. To calculate the specific absorbed fractions by means of the Monte Carlo code MCNP, an appropriate simulation model for the reproductive organs and their surrounding tissues was developed. The contents of rectum and urinary bladder account for the main part of the energy dose in the reproductive organs. Comparison of our results with data from other investigations showed, that lifetime accumulation of Cs 137 and K 40 was too low to cause radiation inferred infertility. (orig.)

  2. My Good, what have we done. From Hiroshima to Chernobyl - our way into nuclear disaster. Mein Gott, was haben wir getan. Von Hiroshima nach Tschernobyl - der Weg in das atomare Verhaengnis

    Energy Technology Data Exchange (ETDEWEB)

    Jaenecke, H

    1987-01-01

    The atomic energy debate has become the life-and-death question of ouer times. But there is great uncertainty, and confusion is increasing. This book leads the reader back to the origin of the atomic age. It describes the progression from a scientific discovery, nuclear fission, to the dropping of the atom bomb - and from the bomb to the supposed blessing of 'peaceful' utilisation of atomic energy. But the bomb and the reactor pose the same threat. After Chernobyl, we know that the apocalypse can happen even without a war. The book is to be read as a narrative in which human personalities play the major roles: Madame Curie, who discovered radioactivity, Edward Teller, the inventor of the hydrogen bomb, the nameless engineers in the control rooms of nuclear power stations who now hold the fate of all of us in their hands. The Appendix contains an interview with Carl Friedrich von Weizsaecker.

  3. Musikalische Vorlieben von Grundschulkindern für Klassik, Neue Musik und Popmusik

    OpenAIRE

    Schellberg, Gabriele; Gembris, Heiner

    2004-01-01

    Musikalische Präferenzen sind in hohem Maße altersabhängig. Im Unterschied zu Erwachsenen und Jugendlichen sind Präferenzen bei Kindern weitaus weniger festgelegt. Die bisherige Forschung zeigt, dass die „Offenohrigkeit“ („openearedness“) jüngerer Kinder bereits im Laufe des Grundschulalters, spätestens mit Beginn der Adoleszenz deutlich abnimmt. Welche musikalischen Vorlieben haben Grundschulkinder? Dazu gibt es in Deutschland keine aktuellen Erhebungen. Das Ziel der vorliegenden Untersuchun...

  4. Übergewicht und Adipositas, Gesundheit und Krankheit : Diskussionsbeiträge aus philosophischer Sicht

    OpenAIRE

    Gottschalk-Mazouz, Niels; Ertelt, Susanne; Radinkovic, Zeljko

    2010-01-01

    Der vorliegende Band vereint Studien, die im Rahmen des Philosophie-Teilprojekts des Forschungsverbunds "Übergewicht und Adipositas bei Kindern, Jugendlichen und jungen Erwachsenen als systemisches Risiko" entstanden sind. Dieser Verbund wurde vom BMBF von 2006-2009 im Rahmen der sozial-ökologischen Forschung im Themenbereich: Strategien zum Umgang mit systemischen Risiken gefördert. In diesem Verbund wurden unter der Leitung des Risikosoziologen Ortwin Renn die Perspektiven von Epidemiologie...

  5. Effect of Ascorbic Acid on Lipoprotein Lipase Activity

    African Journals Online (AJOL)

    1974-03-13

    Mar 13, 1974 ... tone euthanasia and immediate autopsy. The apex of the heart muscle was excised and rinsed in Krebs-Ringer bi- carbonate buffer, blotted on filter paper, weighed, and three times its mass of Krebs-Ringer bicarbonate buffer added. It was then minced with scissors and homogenised for 1 minute with Ultra ...

  6. Toward an improved definition of the genetic and tumor spectrum associated with SDH germ-line mutations

    NARCIS (Netherlands)

    Evenepoel, Lucie; Papathomas, Thomas G.; Krol, Niels; Korpershoek, Esther; De Krijger, Ronald R.; Persu, Alexandre; Dinjens, Winand N M

    2015-01-01

    The tricarboxylic acid, or Krebs, cycle is central to the cellular metabolism of sugars, lipids, and amino acids; it fuels the mitochondrial respiratory chain for energy generation. In the past decade, mutations in the Krebs-cycle enzymes succinate dehydrogenase, fumarate hydratase, and isocitrate

  7. Biological effect and tumor risk of diagnostic x-rays. The ''war of the theories''; Biologische Wirkung und Tumorrisiko diagnostischer Roentgenstrahlen. Der ''Krieg der Modelle''

    Energy Technology Data Exchange (ETDEWEB)

    Selzer, E.; Hebar, A. [Medizinische Universitaet Wien, Abteilung fuer Strahlenbiologie, Klinik fuer Strahlentherapie, Wien (Austria)

    2012-10-15

    Since the introduction of ionizing radiation as a treatment and diagnostic tool in humans, scientists have been trying to estimate its side effects and potential health risks. There is now ample evidence for the principal existence of a direct relationship between higher doses and the risks of side effects. Most of the uncertainties lie in the field of low-dose effects especially with respect to the risk of cancer induction. Low-dose effects are usually of relevance in diagnostic medicine while high-dose radiation effects are typically observed after radiotherapeutic treatment for cancer or after nuclear accidents. The current state of the ''war of theories'' may be summarized as follows: one group of scientists and health regulatory officials favors the hypothesis that there is no threshold dose, i.e. the linear-no-threshold hypothesis (LNT) of radiation which can be regarded as safe. On the contrary, the critics of this hypothesis suggest that the risks of doses below 50 mSv are not measurable or even of clinical relevance and are not adequately described by a linear dose-response relationship. The aim of this article is to summarize the major unresolved issues in this field. Arguments are presented why the validity of the LNT model in the low-dose range should be regarded as at least inconsistent and is thus questionable. (orig.) [German] Seit der Einfuehrung ionisierender Strahlen als ein Mittel zur Behandlung und Diagnose beim Menschen haben Wissenschaftler versucht, ihre Nebenwirkungen und potenziellen Risiken fuer die Gesundheit einzuschaetzen. Es gibt nun ausreichende Evidenz fuer das grundsaetzliche Vorliegen einer direkten Beziehung zwischen hoeheren Dosen und Nebenwirkungsrisiken. Die meisten Unsicherheiten liegen auf dem Gebiet der Niedrigdosisforschung v. a. im Hinblick auf das Risiko der Induktion von Krebs. Niedrigdosiseffekte sind ueblicherweise von Bedeutung in der diagnostischen Medizin, waehrend Hochdosisbestrahlungseffekte

  8. Pediatric brain tumors; Kindliche Hirntumoren

    Energy Technology Data Exchange (ETDEWEB)

    Reith, W.; Bodea, S. [Universitaetsklinikum des Saarlandes, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Homburg/Saar (Germany); Muehl-Benninghaus, R.

    2017-09-15

    Brain tumors differ between children and adults both in histology and localization. Malignant gliomas and meningiomas predominate in adults while medulloblastomas and low-grade astrocytomas are the most frequent brain tumors in children. More than one half (50-70%) of pediatric brain tumors have an infratentorial location but only approximately 30% in adults. Brain tumors can be recognized in sonography, cranial computed tomography (CCT) and magnetic resonance imaging (MRI) by their space-consuming character and by their divergent density and intensity in comparison to normal brain parenchyma. They can grow extrusively, even infiltrate the parenchyma or originate from it. Besides clinical symptoms and diagnostics this article describes the most common pediatric brain tumors, i.e. astrocytoma, medulloblastoma, brainstem glioma, craniopharyngioma, neurofibromatosis and ganglioglioma. The most important imaging criteria are outlined. (orig.) [German] Sowohl Histologie als auch Lokalisation von Hirntumoren unterscheiden sich bei Kindern und Erwachsenen. Waehrend maligne Gliome und Meningeome bei Erwachsenen vorherrschen, kommen bei Kindern ueberwiegend Medulloblastome und niedriggradige Astrozytome vor. Mehr als die Haelfte (50-70 %) aller kindlichen Hirntumoren sind infratentoriell lokalisiert, dagegen sind es bei Erwachsenen nur etwa 30 %. Im Ultraschall, in der kranialen CT (CCT) oder MRT koennen Hirntumoren durch ihren raumfordernden Charakter und ihrer zum normalen Parenchym abweichenden Dichte oder Signalintensitaet erkannt werden. Sie koennen verdraengend wachsen, z. T. auch das Parenchym infiltrieren oder von diesem ausgehen. Neben der klinischen Symptomatik und Diagnostik werden im vorliegenden Artikel die haeufigsten kindlichen Hirntumoren, das Astrozytom, Medulloblastom, Hirnstammgliom, Kraniopharyngeom, die Neurofibromatose und das Gangliogliom beschrieben. Die wichtigsten bildgebende Kriterien werden dargestellt. (orig.)

  9. Untersuchung geschlechtsspezifischer Differenzen in der Melodieentwicklung des Säuglingsschreis zwischen der vierten und achten Lebenswoche unter Berücksichtigung eines möglichen Einflusses von Sexualhormonen auf die Melodiestruktur

    OpenAIRE

    Magsaam, Annika Theresa

    2010-01-01

    Seit den klinischen Beobachtungen Brocas und Wernickes wissen wir, dass die für Sprach-produktion und Sprachperzeption verantwortlichen neuronalen Netzwerke überwiegend in der linken Hemisphäre repräsentiert sind. Allerdings zeigen Männer und Frauen im Erwachsenen-alter eine ungleich starke Ausprägung der sprachfunktionellen Hemisphärendominanz, wobei man annimmt, dass im weiblichen Gehirn verbale Informationen eher bilateral verarbeitet werden, wohingegen im männlichen Geschlecht ein linkshe...

  10. Von Systemkritik zur Anpassung : Wie ein Buch in der Übersetzung die Farbe wechselt / Marianne Vogel

    Index Scriptorium Estoniae

    Vogel, Marianne

    2002-01-01

    Arvustus: Vetemaa, Enn. Die Nixen von Estland : ein Bestimmungsbuch / frei nach E. Vetemaa ; bearbeitet und illustriert von Kat Menschik ; nach dem russischen Übersetzungsmanuskript ins Deutsche übertragen von Günter Jäniche. Frankfurt/M : Eichborn Verlag, 2002.

  11. Gearless. An advanced scanning procedure enables multiturn speed regulators with low wear; Getriebelos. Neues Abtastverfahren ermoeglicht verschleissbare Multiturn-Absolutdrehgeber

    Energy Technology Data Exchange (ETDEWEB)

    Heilmann, J. [IVO GmbH und Co., Villingen-Schwenningen (Germany)

    2002-04-02

    Multiturn encoders for industrial application work without mechanical gears prone to wear and an electronic circuit counts speed consuming lower energy. [German] - Multiturn-Absolutdrehgeber arbeiten je nach Schwerpunkt nach unterschiedlichen physikalischen Prinzipien. - Die fuer den industriellen Einsatz ausgelegten Geber arbeiten ohne verschleissanfaelliges mechanisches Getriebe. - Ein elektronischer Schaltkreis zaehlt die Umdrehungen. (orig.)

  12. Die Mathematik und andere Kurzsprachen : Über John von Neumann, The Computer and the Brain

    NARCIS (Netherlands)

    Leydesdorff, L.; Baecker, D.

    2016-01-01

    Das Buch The Computer and the Brain (1958, dt. 1991; im Folgenden wird nach der deutschen Übersetzung zitiert) ist die gedruckte Version der Silliman Lectures, die zu halten John von Neumann 1956 nach Yale eingeladen worden war. Obwohl sie bis zum März 1956 vorbereitet waren, wurden sie nie

  13. Beiträge zu einer kognitiv ausgerichteten lexikographie | Figge ...

    African Journals Online (AJOL)

    Nach einer "kognitiven Wende" in der Psychologie in der zweiten Hälfte der sechziger Jahre haben auch Teile der Linguistik und der Psycholinguistik begonnen, sich kognitiv zu orientieren. Hier wird ein Modell zugrunde gelegt, nach dem sprachliche Einheiten auf Einheiten des Gedächtnisses referieren. Einheiten des ...

  14. Die Abfallwirtschaft braucht keine Regulierungsbehörde

    OpenAIRE

    Heistermann, Franz; Müller, Martina

    2005-01-01

    In der Folge von stark gestiegenen Preisen für die Abfallentsorgung nach dem Inkrafttreten von abfallrechtlichen Vorschriften am 1. Juni 2005 wurde der Ruf nach einer Regulierungsbehörde für Abfallwirtschaft laut. Besteht Regulierungsbedarf in der Abfallwirtschaft?

  15. Substanzbegriff und systematik

    NARCIS (Netherlands)

    Lütjeharms, W.J.

    1934-01-01

    Bei der Einteilung der Organismen, welche in dieser Arbeit mir von botanischem Gesichtspunkt betrachtet wird, ist die Frage nach „wesentlichen” Merkmalen oder Einteilungsgründen von grosser Wichtigkeit. Es ist die Frage nach der Substanz (Essenz) und den akzidentellen Merkmalen. Der Substanzbegriff

  16. Geschworenengerichte - unbegründete Sorge?

    Directory of Open Access Journals (Sweden)

    Thomas Mühlbacher

    2015-10-01

    Full Text Available Das Fehlen der Begründung des Wahrspruches der Geschworenen ist zunehmender Kritik ausgesetzt und Hauptargument für die Forderung nach der Abschaffung der Geschworenengerichte. Die Abhandlung beschäftigt sich mit dem gegenwärtigen Diskussionsstand und der Suche nach Möglichkeiten, diesen systembedingten und daher nicht sanierbaren rechtsstaatlichen Mangel wenigstens zu mildern.

  17. Tumors of the posterior cranial fossa; Tumoren der hinteren Schaedelgrube

    Energy Technology Data Exchange (ETDEWEB)

    Papanagiotou, P.; Politi, M. [Klinikum Bremen-Mitte/Bremen-Ost, Klinik fuer Diagnostische und Interventionelle Neuroradiologie, Bremen (Germany)

    2016-11-15

    Various types of brain tumor can occur in the region of the posterior fossa. Brain metastases in adults are the most common malignancies at this localization. Ependymomas, medulloblastomas and pilocytic astrocytomas occur mostly in children and only rarely in adults. Other tumors that occur in the posterior fossa are meningiomas, schwannomas, hemangioblastomas, brain stem gliomas and epidermoid tumors. Due to the fact that the various tumors of the posterior fossa have different treatment approaches and prognoses, an accurate and specific diagnosis is mandatory. This review discusses the imaging aspects by computed tomography (CT) and magnetic resonance imaging (MRI) of the most frequent tumors of the posterior fossa. (orig.) [German] Im Bereich der hinteren Schaedelgrube treten verschiedene Typen von Hirntumoren auf, wobei Hirnmetastasen bei Erwachsenen die haeufigsten Malignitaeten in dieser Region darstellen. Ependymome, Medulloblastome und pilozytische Astrozytome kommen meistens bei Kindern und nur selten bei Erwachsenen vor. Weitere Tumoren der hinteren Schaedelgrube sind Meningeome, Schwannome, Haemangioblastome, Hirnstammgliome und Epidermoide. Da die verschiedenen Tumoren der hinteren Schaedelgrube unterschiedliche Behandlungsansaetze sowie Prognosen haben, ist eine genaue und spezifische Diagnose obligatorisch. Dieser Review diskutiert die bildgebenden CT- und MRT-Aspekte der haeufigsten Tumoren der hinteren Schaedelgrube. (orig.)

  18. On the effect of small radiation doses: Desoxyribonucleic acid (DNA) synthesis and DNA repair of thymus, spleen, and bone marrow cells in the rat after fractionated total body X-ray irradiation. Zur Wirkung kleiner Strahlendosen: Desoxyribonukleinsaeure-(DNA-)Synthese und DNA-Reparatur von Thymus-, Milz- und Knochenmarkszellen der Ratte nach fraktionierter Ganzkoerperroentgenbestrahlung

    Energy Technology Data Exchange (ETDEWEB)

    Tempel, K.; Ehling, G. (Muenchen Univ. (Germany, F.R.). Inst. fuer Pharmakologie, Toxikologie und Pharmazie)

    1989-09-01

    After three to seven days following to fractionated total body X-ray irradiation (TBI) (four expositions with doses of 0.3 to 5.0 cGy per fraction at intervals of 24 hours), a maximum 50 percent stimulation of the semiconservative DNA synthesis (SDS) of spleen cells was measured in vitro. This was not dependent of the fact if an acute high-dose (400 and/or 800 cGy) unique irradiation was applied after the fractionated TBI at the moment of stimulation. A significant increase of {sup 3}H-thymidine incorporation into the DNA of bone marrow and thymus cells was only found when doses of 1.25 cGy per fraction had been used. After fractionated TBI with doses of {ge}5 cGy per fraction, an increase of DNA synthesis resistant to hydroxyurea ('unprogrammed' DNA synthesis, UDS) was demonstrated in spleen cells. The UV-simulated UDS decreased proportionately. The sedimentation of thymus, spleen, and bone marrow nucleoids in a neutral saccharose gradient gave no evidence of an increased DNA repair capacity after fractionated TBI. Whereas the SDS stimulation by fractionated TBI with small doses can be explained by a modified proliferation behavior of exposed cells, the UDS behavior of spleen cells after considerably higher radiation doses suggests regenerative processes correlated with an increased number of cells resistant to hydroxyurea and cells presenting an UV repair deficiency. These findings can be considered to be a further proof of the assumed immune-stimulating effect of small radiation doses. (orig.).

  19. Measurement of Kr-85 and Xe-133 as undisturbed tracers for the representing of atmospheric transport after disposal of radioactivity from nuclear facilities; Messungen von Kr-85 und Xe-133 als ungestoerte Tracer zur Darstellung atmosphaerischer Transportvorgaenge nach Freisetzung von Radioaktivitaet aus kerntechnischen Anlagen

    Energy Technology Data Exchange (ETDEWEB)

    Frank, G.; Steinkopff, T. [Deutscher Wetterdienst (Germany); Salvamoser, J. [Institut fuer Angewandte Isotopen-, Gas- und Umweltuntersuchungen (IGU), Woerthsee (Germany)

    2016-07-01

    The Deutscher Wetterdienst (DWD, German Meteorological Service) operates since 1996 a sampling and measurement device for the radioactive rare gases Kr-85 and Xe-133 in Offenbach. These measurements are embedded in the German Measurement and Information System for Monitoring Environmental Radioactivity (Integriertes Mess- und Informationssystem zur Ueberwachung der Radioaktivitaet in der Umwelt, IMIS) [1]. In addition to these measurements the DWD is sampling rare gases in Potsdam and since 2014 in Trier in cooperation with the Bundesamt fuer Strahlenschutz (Federal Office for Radiation Protection, BfS). In the frame of the Global Atmosphere Watch (GAW)-program of the WMO the DWD operated a sampling station at the Zugspitze (Schneefernerhaus) from 1999 to 2005. This location at the Zugspitze is well suited for the observation of long distance transport of Kr-85 in the higher atmosphere. The DWD in Offenbach operates a complex analytical system for the measurement of Kr-85 and Xe-133 since 1998. This system consists of sampling with first enrichment, second enrichment, gas chromatographic separation and preparation of Krypton and Xenon and measurement of Kr-85 and Xe-133. Using the example Fukushima, it is shown, that the radioactive rare gases Kr-85 and Xe-133 are well undisturbed tracers for atmospheric transport in case of a nuclear accident or routine nuclear reprocessing plants. Measurements of Xe-133, I-131, Cs-137 and Kr-85 are correlated with source and atmospheric transport to the sampling sites at Offenbach and Potsdam.

  20. Search for a final repository. Final repository commission and the public. Questions concerning cooperation and progress of the process at half time of the commission; Endlagersuche. Endlager-Kommission und Oeffentlichkeit(en). Fragen nach Zusammenarbeit und Fortschritten im Prozess zur Halbzeit der Kommission

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, Monika C.M. (ed.) [Evangelische Akademie Loccum (Germany). Arbeitsbereich Naturwissenschaften, Oekologie und Umweltpolitik

    2016-08-01

    The volume includes the following contributions: Presumptions and success of public participation. Refusal as legitimate and necessary mean. Experiences form the participation process in Switzerland. Cooperation of the final repository commission and the public. Regional participation: the view of a process attendant in the Swiss procedure. Synergies or friction losses? Who is coordinating the institutions/activities and is bringing them together? Players in the nuclear waste conflict - rights and duties in the frame of the search for waste storage as safe as possible. Transparency and Participation - what is the role of online media in the site search process?.

  1. Handbook of quality management according to the regulation DIN EN ISO/IEC 17025 for the national EU reference laboratory or air quality at the Federal Office for Environmental Protection. State of the art: September 2009; Qualitaetsmanagement-Handbuch nach DIN EN ISO/IEC 17025 fuer das Nationale EU-Referenzlabor fuer Luftqualitaet im Umweltbundesamt. Stand September 2009

    Energy Technology Data Exchange (ETDEWEB)

    Medem, Anneliese (comp.)

    2010-01-15

    The past quality management manual of the national EU reference laboratory for air quality completely was revised. The new quality management manual under consideration contains a determination of the following aspects: Organisation of construction processing, fundamental regulations of the management system concerning to quality, statements to the quality politics, paramount goals. The presented quality management system is regarded to all elements of the regulation DIN EN ISO/IEC 17025:2005 with consideration of the special requirements of the national European Union reference laboratory for air quality in the Federal Office for Environment Protection (Dessau-Rosslau, Federal Republic of Germany).

  2. New EN standards for flanges and weld-on fittings now in force. Tricky in the detail, but design of a pipeline entirely in conformity to European codes and standards is possible; Neue EN-Normen fuer Flansche und Schweissfittings in Kraft. Tuecken im Detail, aber die Konstruktion einer Rohrleitung komplett nach Europaeischem Regelwerk wird moeglich

    Energy Technology Data Exchange (ETDEWEB)

    Willauschus, A. [BUHLMANN Rohr-Fittings-Stahlhandel GmbH und Co. KG, Hilden (Germany)

    2008-07-15

    The second edition of EN 1092, Part 1, 'Circular steel flanges', with date of issue November, 2007, the calculation rules of which are now based on the Woelfel-formulae, is now in force. This new edition had become necessary because the June 2002 edition was, indeed, based on EN 1591 as a calculation tool, but only flanges up to DN 600 had been calculated. Rapid establishment of the new EN 1092, Part 1, on the market can be anticipated following this new edition, since the new pipe classes of the chemicals industry, published in PAS 1057, are based on the new EN 1092, Part 1, and BASF has now also become the first major chemicals corporation to convert its flange ordering to this EN standard, starting in early 2008. From 2009 onward, all other major chemicals companies, which drafted PAS 1057 jointly in the 'Pipelines Working Committee' within the 'Process-Engineering Corporation of BDI', will successively follow. The 'Specialist Confederation for Steel Flanges' is also already working on a new flange catalogue based on EN 1092, Part 1. (orig.)

  3. Double-strand break induction and DNA damage response after {sup 12}C ion and photon radiation in U87 glioblastoma cells; Doppelstrangbruch-Induktion und DNA-Schadensantwort nach {sup 12}C-Ionen- und Photonenstrahlung in U87 Glioblastomzellen

    Energy Technology Data Exchange (ETDEWEB)

    Lopez Perez, Ramon

    2015-04-22

    Heavy ion radiation has greater biological effectiveness than the same physical dose of photon radiation. In this work the underlying reasons in the DNA damage response were analyzed in U87 glioblastoma cells. DNA double-strand breaks (DSBs) are the decicive lesions for the effectiveness of ionizing radiation. Their induction and repair was measured in the context of the cell cycle based on the DSB marker γH2AX (the phosphorylated form of the histone variant H2AX). Further, radiation-specific differences in choice of the DSB repair pathway was analyzed, as well as the consequences of repair failure. The results showed that in contrast to photons, {sup 12}C ion radiation produces more severe DSBs that are repaired delayed and with slower kinetics. Accordingly, stronger and longer lasting cell cycle delays, predominantly at the G2/M border, and a higher rate of apoptosis was detected for {sup 12}C ion radiation. Autophagy, an alternative mechanism of programmed cell death, was not relevant for neither of the two types of radiation. The effect of {sup 12}C ion radiation was less dependent on the cell cycle stage than for photon radiation. This became particularly evident in the DSB repair velocities during S- and G2-phase. After {sup 12}C ion radiation, cells were more dependent on homologous recombination repair (HRR) compared to photon radiation. The reason therefore that in contrast to photons, {sup 12}C ion radiation induced graver DSBs that were repaired slower and more dependent on HRR, was most probably enhanced clustering of DSBs due to the higher ionization density of {sup 12}C ion radiation. Microscopic inspection of immunofluorently stained γH2AX revealed that {sup 12}C ion radiation induced bigger DSB repair foci containing more γH2AX molecules (higher fluorescence intensity), although their initial number was smaller. Besides the foci, a weaker pan-nuclear γH2AX staining was observed that increased in a dose-dependent manner and was more pronounced for {sup 12}C ion compared to photon radiation. Pan-nuclear γH2AX caused by ionizing radiation can be linked to the induction of small DNA fragments. These results indicated that the clustering of DSBs, rather than their sheer number, is decicive for the high relative biological effectiveness of {sup 12}C ion radiation. Further hints for clustered DSBs after {sup 12}C ion radiation were found by application of superresolution microscopy to analyze repair foci after immunofluorescent staining of γH2AX and the HRR enzyme pBRCA1. Therefore, cells were irradiated with individual or only few {sup 12}C ions under a flat angle. With the help of structured illumination microscopy (SIM), the foci and their colocalization could be measured with high accuracy beyond the classical resolution limit in 3D. Besides primary foci induced along the ion trajectory, new secondary foci appeared after 26h. They were scattered offside the ion track and were presumably caused by unrepaired non-DSB lesions in the course of DNA replication. In accordance with the dependency of such secondary DSBs on repair by break-induced replication, a HRR subpathway, colocalization between γH2AX and pBRCA1 was particularly high in the secondary foci. The inner structure of γH2AX foci was further analyzed with SPDM{sub Phymod}, another superresolution microscopy technique. This revealed that the foci, that can reach sizes up to more than 1,5 μm{sup 3}, possess a fine substructure rather than being homogenous. The results indicated that the foci are composed of several subfoci in the range of 100 nm with partially elongated shape. In accordance with the organization of chromatin in densely packed loops with interchromatin spaces, different structures and distances between the subfoci could be observed.

  4. Good luck. Rural district. The black coal mining since 1945. The first special exhibition in the new building of the German mining industry museum Bochum; Glueck auf. Ruhrgebiet. Der Steinkohlenbergbau nach 1945. Erste Sonderausstellung im Neubau des Deutschen Bergbau-Museums Bochum

    Energy Technology Data Exchange (ETDEWEB)

    Farrenkopf, Michael [Montanhistorisches Dokumentationszentrum, Bochum (Germany); Deutsches Bergbau-Museum Bochum (Germany). Forschungsgebiet Juengere Bergbaugeschichte

    2010-03-15

    As one of the eight large research museums in the Federal Republic of Germany and as a member of the Leibniz Society (Bonn, Federal Republic of Germany), the German mining industry museum Bochum understands its special exhibitions as a result of a large-scale research project. Contrary to other institutions for science, the research museums use the chance to publish their research results in the sense of 'Public Understanding of Science' to the broad public. To this extent, research museums have an important educational function for our modern society.

  5. Durchführung der universitären Prüfungen im klinischen Abschnitt des Medizinstudiums nach den Leitlinien des GMA-Ausschusses Prüfungen: Eine Bestandsaufnahme der medizinischen Fakultäten in Baden-Württemberg [Implementation of assessments according to the guidelines of the GMA: A survey of the medical faculties in Baden-Württemberg

    Directory of Open Access Journals (Sweden)

    Jünger, Jana

    2010-08-01

    Full Text Available [english] With the introduction of the new medical licensing regulation [1] in 2002, a reform process was initiated nationwide that aimed to redesign medical degree programs at universities to make them more practice-oriented and to establish quality assurance in teaching. Five centers of excellence were set up at the medical schools in Baden-Württemberg that merged to form the Network for Excellence in Medical Education.The Network for Excellence in Medical Education carried out a survey among the five medical schools in Baden-Württemberg on the implementation of the requirements set down in the GMA guidelines for university-specific, high-quality assessments during the clinical phase of medical studies. The network’s next steps for improving the quality of assessments at medical schools were prioritized in order to determine the urgency of support to be given to Baden-Württemberg’s faculties of medicine in implementing the GMA requirements.It became apparent that essential parts of the requirements formulated in the guidelines had already been fulfilled or at least could be fulfilled in the near future. It was observed that establishing structured review processes during assessment preparation and in particular the follow-up presented considerable difficulties. A focus group analysis identified the following objectives for the network: supporting medical schools in their review processes; compiling a comprehensive assessment program and assessment reports with statistical analysis. Training the people responsible for assessment is another priority.The results largely correspond to those from a similar survey carried out among medical schools in Bavaria and show that organizational structures, such as those that have been established in the centers of excellence in education and assessment in Baden-Württemberg and Bavaria, can offer essential support in the quality assurance of assessment.[german] Mit der Einführung der novellierten Ärztlichen Approbationsordnung im Jahr 2002 wurde bundesweit ein Reformprozess in Gang gesetzt, mit dem Ziel, das Medizinstudium an den Universitäten praxisorientierter zu gestalten und eine Qualitätssicherung im Bereich der Lehre zu etablieren. Um hierbei die medizinischen Fakultäten Baden-Württembergs zu unterstützen, wurden fünf Kompetenzzentren an den medizinischen Fakultäten des Landes gegründet, die sich zum Kompetenznetz Lehre Baden-Württemberg zusammengeschlossen haben.Das Kompetenznetz Lehre hat an den fünf medizinischen Fakultäten Baden-Württembergs eine Befragung zum Umsetzungsstatus der in der GMA-Leitlinie für fakultätsinterne Leistungsnachweise dargelegten Anforderungen an qualitativ hochwertige Prüfungen im klinischen Abschnitt des Medizinstudiums durchgeführt. Um den vordringlichen Bedarf für die Unterstützung der medizinischen Fakultäten des Landes Baden-Württemberg bei der Umsetzung der Leitlinien durch das Kompetenznetz Lehre zu ermitteln, wurde eine Priorisierung der nächsten Aufgaben bei der Verbesserung der Qualität der universitären medizinischen Prüfungen vorgenommen.Es zeigte sich, dass wesentliche Teile des in den Leitlinien formulierten Anforderungskatalogs bereits erfüllt wurden oder wenigstens mittelfristig an den Fakultäten umsetzbar sind. Festgestellt wurde aber, dass die Etablierung strukturierter Reviewprozesse bei der Prüfungsvorbereitung und insbesondere der Nachbereitung noch auf deutliche Schwierigkeiten stößt. Im Rahmen einer Fokusgruppenanalyse wurden als vorrangige Arbeitsziele für das Kompetenznetz Lehre die Unterstützung der medizinischen Fakultäten für den Begutachtungsprozess der Prüfungsaufgaben („Review“, die Erstellung eines Gesamtprüfungsprogramms und von Prüfungsberichten mit statistischer Auswertung definiert. Einen weiteren Schwerpunkt bildet die Qualifizierung von Prüfungsverantwortlichen zum Thema Prüfungen.Die Ergebnisse decken sich im Wesentlichen mit einer ähnlichen Befragung der medizinischen Fakultäten in Bayern und zeigen, dass organisatorische Strukturen, wie sie mit den Kompetenzzentren für Lehre und Prüfungen in Baden-Württemberg und Bayern geschaffen wurden, eine wesentliche Hilfestellung bei der Qualitätssicherung von Prüfungen bieten können.

  6. Consequences of the feed-in management for the marketing of electric power from renewable energies. Are limited generators financially shut-down according to paragraph 13 par. 4 EnWG; Folgen des Einspeisemanagements fuer die Vermarktung von Strom aus Erneuerbaren Energien. Werden zwangsweise abgeregelte Erzeuger nach paragraph 13 Abs. 4 EnWG bilanziell glattgestellt?

    Energy Technology Data Exchange (ETDEWEB)

    Soetebier, Jan [Bundesnetzagentur, Bonn (Germany)

    2012-09-15

    With the expansion of renewable energies, the network capacities on windy and sunny days are becoming scarce. If the capacities are not sufficient in order to accommodate all the electricity, conventional power plants and subordinately plants for the power generation from renewable plants have to be closed. What are the consequences of a compulsory curtailment for the marketing of the electric power? This question basically raised for conventional power plants as well as supply remunerated and directly exploited renewable energy plants. From this perspective, the author of this contribution reports on the impact on the stock marketing of the supply remunerated electric power from renewable energy sources according to the balancing mechanism of the Renewable Energy Law.

  7. Protection of the climate in Germany. Second report presented by the Government of the Federal Republic of Germany according to the United Nations Agreement on Climatic Changes; Klimaschutz in Deutschland. Zweiter Bericht der Regierung der Bundesrepublik Deutschland nach dem Rahmenuebereinkommen der Vereinten Nationen ueber Klimaaenderungen

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-11-01

    This report is the second government report after the climate convention. It contains an inventory of emissions of relevance for the greenhouse effect and the states where they are stored (forest) plus a description of the government`s preventive measures to protect the climate. You can find emission scenarios and the projection to the years 2000, 2005, 2010 and 2020 and an assessment of the effects of the measures. (orig./SR)

  8. Change of supplier in the power industry: the problem of network takeover paying for present market value, seen against the background of the institution of price control in compliance with paragraph 12 of the Federal electricity rate system. Versorgerwechsel in der Stromwirtschaft: Die Problematik der Netzuebernahme zum Sachzeitwert vor dem Hintergrund der Preisaufsicht nach Paragraph 12 Bundestarifordnung Elektrizitaet

    Energy Technology Data Exchange (ETDEWEB)

    Schaefer, G.

    1993-01-01

    There are three arguments put forward in favour of a takeover paying for the present market value: - There would be no effect on consumer prices. - It is a fair compromise that can be accepted by both utilities. - The law on franchise agreements requires takeovers to be based on the present value principle. None of these arguments will bear closer scrutiny in the light of the law on pricing schemes, franchise agreements, or the specific conditions governing the electricity market. The author shows that takeover contracts on the basis of present value payment would involve double counting of costs and thus would create considerable price increasing effects. The other side of the coin is: Since the price supervisory authority will not allow double counting, the utility taking over a network at present value would have to bear all economic disadvantages. (orig.)

  9. Radiation protection primer. What everybody should know, observe, avoid, or do for his own personal protection in an environment affected by the Chernobyl accident. Die Strahlenschutz-Fibel. Was der Buerger nach der Katastrophe von Tschernobyl wissen, beachten, vermeiden, tun sollte

    Energy Technology Data Exchange (ETDEWEB)

    Aigner, R; Melzer, E; Seissler, H

    1986-01-01

    This 'radiation protection primer' does not pretend to give absolute, final answers to the many questions that have been arising after the Chernobyl accident. What it is intended to supply, as a schematic overview of problems resulting from nuclear accidents, and a likewise systematic outline of possible solutions and sensible reactions to such an event. The book takes up questions such as: What has happened to the soil. Will future harvests be 'clean' again. What does radioactivity to our drinking water and other waters. What are the effects of a radioactive fallout on food. What may we eat or drink. What happens to the human body after intake of radioactive air, or - even only slightly - contaminated food or water. What can we do to protect our health, and the health of our children. Is there anything else we can do in order to avoid such a disaster in future, except from shutting-off all reactors. The book itself presents some answers and advice, along with a list of terms and explanations, and addresses to apply to for further advice and information.

  10. The accident in Fukushima. Preliminary report on the accident progress in the nuclear power plants as a consequence of the earth quake on 11th March 2011; Der Unfall in Fukushima. Zwischenbericht zu den Ablaeufen in den Kernkraftwerken nach dem Erdbeben vom 11. Maerz 2011

    Energy Technology Data Exchange (ETDEWEB)

    Borghoff, Stefan; Brueck, Benjamin; Kilian-Huelsmeyer, Yvonne; Maqua, Michael; Mildenberger, Oliver; Quester, Claudia; Stahl, Thorsten; Thuma, Gernot; Wetzel, Norbert; Wild, Volker

    2011-08-15

    The preliminary report on the accident progress in the nuclear power plants as a consequence of the earth quake on 11th March 2011 describes the chronologic sequence of the accident in the different units of the power plant. The measures for mitigation of the accident impact at the site of Fukushima Daiichi and Fukushima Daini included the efforts to reach and maintain stable plant conditions. The issue radiological situation includes an estimation of the air-borne radionuclide release, the contamination of the environment and the sea water, measures for protection of the public. The lessons learned following the NISA and IAEA fact finding missions and the open questions are summarized.

  11. Valuation of electricity transmission systems in case of transfer to successor upon termination of a franchise agreement. OLG Celle (Celle Higher Regional Court), decision of 6 Nov. 1996 - Az. 13 U (Kart) 275/95; Wertbemessung bei Uebergang von Versorgungsanlagen nach Auslaufen eines Konzessionsvertrages. OLG Celle, Urteil vom 6.11.1996 - Az. 13 U (Kart) 275/95

    Energy Technology Data Exchange (ETDEWEB)

    Anon.

    1997-08-01

    (Appealable) head note: A termination clause in franchise agreements containing a mutually agreed title to transfer of ownership of power distribution systems against payment of the replacement value are legally effective. On the definition of the term ``replacement value``. (orig.) [Deutsch] Leitsatz (nicht amtlich): Eine Endschaftsklausel in Konzessionsvertraegen, in der ein Anspruch auf Uebertragung der Versorgungsanlagen zum sog. Sachzeitwert vereinbart wird, ist wirksam. Zur Inhaltsbestimmung des Sachzeitwertbegriffs. (orig.)

  12. MRI based volumetric assessment of knee cartilage after ACL-reconstruction, correlated with qualitative morphologic changes in the joint and with clinical outcome. Is there evidence for early posttraumatic degeneration?; MRT-basierte Knorpelvolumetrie nach Kreuzbandersatzplastik in Korrelation mit qualitativen Gelenkveraenderungen und dem klinischen Outcome. Gibt es Hinweise auf fruehzeitige posttraumatische degenerative Veraenderungen?

    Energy Technology Data Exchange (ETDEWEB)

    Arnoldi, A.P.; Weckbach, S.; Horng, A.; Reiser, M. [Ludwig-Maximilians-Univ. Muenchen (Germany). Dept. of Clinical Radiology; Nussbickel, C. [Klinikum Garmisch-Partenkirchen (Germany). Dept. of Internal Medicine; Noebauer, I. [Medizinische Universitaet Wien (Austria). Klinik fuer Radiodiagnostik; Zysk, S. [Orthopaedie Zentrum Groebenzell (Germany). Center of Orthopaedics; Glaser, C. [NYU Medical Center, New York, NY (United States). Dept. of Radiology

    2011-12-15

    Purpose: The purpose of this study was to analyze potential quantitative and qualitative changes of the knee cartilage and joint indicative of early posttraumatic OA 4 years after ACL-reconstruction and to correlate the MRI-findings with the clinical outcome (CO). Materials and Methods: 1.5 T MRI-scans were performed on 9 patients post-op and 4 years later. Using a high-resolution T 1-w-fs-FLASH-3D-sequence cartilage volume (cVol) and thickness (mTh) were quantified. Using standard PD-w fs and T 1-w sequences qualitative changes of the joint structures were analyzed based on the WORMS-score. CO was rated by an orthopaedic surgeon using Lysholm-score, OAK-score, Tegner-activity-score (TAS), and Arthrometer KT-1000 testing. Results: Mean changes of cVol were -1.8 % (range: -5.9 %; + 0.7 %) and of mTh -0.8 % (range: -3.0 %; + 1.1 %). No significant change (95 %-CI) could be identified for any compartment. Three patients developed new peripatellar ostheophytes, acute trauma related changes mostly decreased. Mean outcome of Lysholm-score and OAK-score were 90 pts and 86 pts, mean TAS was 4.3 pts. Average maximum tibial translation reached 5.2 mm comparing to 6.7 mm on the healthy contralateral side. Conclusion: Despite a tendency towards decreased cVol and mTh 4 years after ACL-reconstruction qMRI revealed no significant cartilage loss. Newly developing osteophytes did not match with the observed good CO. This small pilot study motivates future quantitative and qualitative-structural MRI-based assessment of articular cartilage and other joint structures in order to improve diagnostic tools for the detection of early OA. (orig.)

  13. Determination of limestone balance from statistical data of the German Federal Institute for Geosciences and Natural Resources. Emissions reporting in accordance with the Framework Convention on Climate Change and the Kyoto Protocol (Category CRF 2.A.3); Ableitung der Kalksteinbilanz aus den statistischen Daten der Bundesanstalt fuer Geowissenschaften und Rohstoffe. Emissionsberichterstattung nach Klimarahmenkonvention und Kyoto-Protokoll (Kategorie CRF 2.A.3)

    Energy Technology Data Exchange (ETDEWEB)

    Roehling, Simone [Bundesanstalt fuer Geowissenschaften und Rohstoffe, Hannover (Germany); Kludt, Robert [Umweltbundesamt, Dessau (Germany)

    2010-11-15

    Balances are possible on the basis of statistical data or on the basis of indicators. The indicator-based approach in combination with the irreplaceable statistical balance items would seem to be more appropriate from a technical point of view. The balance calculations should however only be used to provide an overview of limestone use, i.e. they should only be used to verify the activity data8. The emission calculations should always be made in the source groups in which limestone is used. This also makes it possible to take account of all emissionrelevant carbonates in the source groups, which results in much more accurate calculations. (orig.)

  14. The quest for narrow e{sup +}e{sup -} cumulative energy distributions heavy ion collisions. The GSI e{sup +}e{sup -} puzzle; Die Suche nach schmalen e{sup +}e{sup -} Summenenergieverteilungen in Schwerionenkollisionen. Das GSI e{sup +}e{sup -}-Puzzle

    Energy Technology Data Exchange (ETDEWEB)

    Ganz, R.

    1995-12-01

    The examination of electron-positron pairs which are emitted in heavy-ion collisions at the Coulomb barrier was continued with the newly designed EPoS II spectrometer at the UNILAC accelerator. The objective of the experiments was to further analyse the narrow line structures in the positron-electron cumulative energy distributions, which were observed in preceding measurements examining the collision systems U 238 + Th 232 and U 238 + Ta181 with the EPOS I spectrometer. By means of a reproduction experiment, the existence of the lines was statistically verified relying on a large data pool. [Deutsch] Die Untersuchung von Elektron- Positron Paaren, die bei Schwerionenkol lisionen an der Coulombbarriere emittiert werden, wurde mit dem neu kon zipierten EPoS II Spektrometer am UNILAC- Beschleuniger fortgesetzt. D ie Motivation der Experimente war die weitere Untersuchung der schmale n Linienstrukturen in den Positron- Elektron- Summenenergieverteilunge n, die in vorangegangenen Messungen der Stosssysteme U 238+ Th 232 un d U 238+ Ta 181 mit dem EPOS I Spektrometer beobachtet wurden. Durch ei ne Reproduktion wurde die Existenz der Linien anhand einer grossen Date nmenge statistisch sicher geprueft.

  15. Influence of a pre-treatment with lithium, anabolic agents and hypertransfusion on the regeneration of the hematopoiesis in mice after radiation damage. Einfluss einer Vorbehandlung mit Lithium, Anabolikum und Hypertransfusion auf die Regeneration der Haematopoese bei der Maus nach Strahlenschaden

    Energy Technology Data Exchange (ETDEWEB)

    Bartenstein, P.

    1985-08-27

    In this work it was investigated, whether a week-long pre-treatment with Lithium carbonate, the anabolic agent Deca-Durabolin and syngeneic blood transfusions effected a stimulation, especially of the granulopoiesis, in mice and whether with these measures an increase in the number of pluripotent and myeloically determined stem cells CFUs and CFUc was attained. Further, the question was followed, to what extent these measures have a positive affect on the regeneration of hematopoiesis after radiation damage. Because these therapeutic interventions influence the hematopoiesis through various mechanisms, the detection of eventually present, additive effects should be done using a combination of these types of treatment.

  16. Energy policy turnaround and network stability. The new legal general conditions for operators of transmission networks and distribution networks according to paragraph paragraph 13, 14 EnWG; Energiewende und Netzstabilitaet. Die neuen rechtlichen Rahmenbedingungen fuer Uebertragungs- und Verteilernetzbetreiber nach paragraph paragraph 13, 14 EnWG

    Energy Technology Data Exchange (ETDEWEB)

    Weise, Michael; Hartmann, Thies Christian [Becker Buettner Held, Berlin (Germany); Woeldeke, Frank [Braunschweiger Netz GmbH, Braunschweig (Germany)

    2012-06-15

    Network operators have a legal obligation to operate a safe, reliable and efficient energy supply system. The energy policy turnaround in summer 2011 make this order to a special challenge. The further increase in decentralized power supply and the loss of power generation capacity due to the nuclear phase-out are significant factors influencing the safety and reliability of energy supply. The legislator has already changed the central regulations of the Energy Economy Act. The authors of the contribution under consideration present an overview of the current legal framework for network operators. Subsequently, individual measures are presented.

  17. Scintigraphy by sup 99m Tc-in vivo labeled red blood cells. Detection of gastrointestinal bleeding following duodenum-preserving resection of the head of the pancreas. Die Szintigraphie mit sup 99m Tc-in-vivo-markierten Erythrozyten. Nachweis einer intestinalen Blutung nach duodenumerhaltender Pankreaskopfresektion

    Energy Technology Data Exchange (ETDEWEB)

    Brecht-Krauss, D. (Ulm Univ. (Germany, F.R.). Abt. Nuklearmedizin); Schnarkowski, P.; Friedrich, J.M. (Ulm Univ. (Germany, F.R.). Abt. Roentgendiagnostik)

    1990-09-01

    Following resection of the head of the pancreas while preserving the duodenum a gastrointestinal haemorrhage was localised by red blood cells labeled in vivo with technetium-99m. The previously performed endoscopy and angiography were normal. The haemorrhage in the region of the pancreaticojejunal anastomosis was confirmed intraoperatively. If intermittent bleedings are suspected, scintigraphy should be performed as a routine measure besides endoscopy and angiography. (orig.).

  18. Transmission contracts and procurement law. Applicability of the instructions of the procurement law to the selection procedure in the connection with the conclusion of transmission contracts according to paragraph 46 EnWG?; Konzessionsvertraege und Vergaberecht. Anwendbarkeit der Vorschriften ueber das Vergaberecht auf das Auswahlverfahren beim Abschluss von Wegenutzungsvertraegen nach paragraph 46 EnWG?

    Energy Technology Data Exchange (ETDEWEB)

    Niehof, Roland

    2011-01-15

    The conclusion of transmission contracts between the municipalities and the operators of supply lines (electricity, natural gas) is regulated by law. paragraph 46 of the Energy Economy Law (EnWG) describes the requirements concerning the selection a power supply company and concerning the procedure to be followed. The contribution under consideration examines whether the regulations of the procurement right can be applied directly or similarly beside paragraph 46 EnWG to the conclusion of transmission contracts. The author of the contribution under consideration deals with the newer jurisdiction of the European Court of Justice.

  19. Legal requirements on the arrangement of the selection procedure for the authorisation of power concession and natural gas concession according to paragraph 46 EnWG; Rechtliche Anforderungen an die Ausgestaltung der Auswahlverfahren zur Vergabe von Strom- und Gaskonzessionen nach paragraph 46 EnWG

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, Henning; Embacher, Patrick [Roedl und Partner GbR, Koeln (Germany); Wolf, Thomas [Roedl und Partner GbR, Nuernberg (Germany)

    2012-08-15

    By the Act on Redefining the energy industry regulations, on 26th July, 2011 the Federal Legislature has made extensive changes and amendments to the Energy Economy Law (EnWG). The aim of the paragraph 1 section 1 EnWG is the requirement that the power supply must be safe, affordable, user-friendly, efficient and environmentally safe for the general public. From paragraph 2 arise the objectives of ensuring effective and undistorted competition in the energy supply and the long-term performance and reliable operation of power distribution systems. The economic interests of local communities are not explicitly mentioned.

  20. Exercise ''contact point for persons from the neighborhood of a nuclear power station after a severe accident''; Uebung ''Kontaktstelle fuer Personen aus der Umgebung eines Kernkraftwerkes nach einem schweren Unfall''

    Energy Technology Data Exchange (ETDEWEB)

    Stuerm, R.P. [SafPro AG, Ausbildung und Beratung in Strahlenschutz, Basel (Switzerland); Schubiger, V.; Voegtli, M. [Abt. Militaer und Bevoelkerungsschutz des Kantons Aargau (Switzerland)

    2001-07-01

    After a severe nuclear power station accident with release of radioactivity, some few persons in the neighbourhood of the station may accumulate a dose of more than 1 Sv. A lot of other people may be in doubt, whether they have received a radiation dose. Hospitals and practitioners may break down under the run on them by terrified persons, who have no or only small doses. In order to prevent this, 'assembly centers' should be run at the outer limit of the irradiated area. About 1'000 persons per day from the INNER, MIDDEL and OUTER irradiated regions should be informed and psychologically attended. A concept for such a 'assembly center' has been elaborated by members of the National Commission for AC-Protection, the Office for Protection of the Population, the National Alarm Center, the Swiss Inspectorate for the Safety of Nuclear Power Stations as well as public health officers. The concept has been tested in an exercise with 185 persons. (orig.) [German] Wenn bei einem schweren KKW-Unfall mit Austritt von Radioaktivitaet die alarmierte Bevoelkerung die angeordneten Schutzmassnahmen nicht ergreifen wuerde, koennten in der allernaechsten Umgebung des KKW einige wenige Personen Strahlendosen von mehr als 1 Sv akkumulieren und in der weiteren Umgebung viele Personen mittlere und kleine Dosen erhalten. Um eine moegliche Strahlendosis bei diesen Personen (aber auch bei solchen, die im Zweifel sind) zu ermitteln, sollen am Rande der betroffenen Region Informationsstellen mit orts-