xdamp Version 6.100: An IDL(reg sign)-based data and image manipulation program

International Nuclear Information System (INIS)

Ballard, William Parker

2012-01-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA(trademark) (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows(trademark) computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 2

Energy Technology Data Exchange (ETDEWEB)

None

1993-08-01

A thermal analyses for the 10CFR71 normal conditions of . transport and hypothetical accident conditions is presented for the conceptual NUHOMS{reg_sign} Transportation Cask and NUHOMS{reg_sign}-24P DSC system. The purpose of the thermal analyses presented herein is to demonstrate that the conceptual NUHOMS{reg_sign} Transportation Cask with the NUHOMS{reg_sign}-24P DSC provides suitable heat dissipation to maintain the heat removal capacity of the loaded NUHOMS{reg_sign} Transportation Cask. The thermal analyses results show that the maximum temperatures and pressures of the NUHOMS{reg_sign} Transportation Cask and the NUHOMS{reg_sign}-24P DSC are within their allowable material temperature and pressure limits.

Identification of RegIV as a novel GLI1 target gene in human pancreatic cancer.

Directory of Open Access Journals (Sweden)

Feng Wang

2011-04-01

Full Text Available GLI1 is the key transcriptional factor in the Hedgehog signaling pathway in pancreatic cancer. RegIV is associated with regeneration, and cell growth, survival, adhesion and resistance to apoptosis. We aimed to study RegIV expression in pancreatic cancer and its relationship to GLI1.GLI1 and RegIV expression were evaluated in tumor tissue and adjacent normal tissues of pancreatic cancer patients and 5 pancreatic cancer cell lines by qRT-PCR, Western blot, and immunohistochemistry (IHC, and the correlation between them. The GLI1-shRNA lentiviral vector was constructed and transfected into PANC-1, and lentiviral vector containing the GLI1 expression sequence was constructed and transfected into BxPC-3. GLI1 and RegIV expression were evaluated by qRT-PCR and Western blot. Finally we demonstrated RegIV to be the target of GLI1 by chromatin immunoprecipitation (CHIP and electrophoretic mobility shift assays (EMSA.The results of IHC and qRT-PCR showed that RegIV and GLI1 expression was higher in pancreatic cancer tissues versus adjacent normal tissues (p<0.001. RegIV expression correlated with GLI1 expression in these tissues (R = 0.795, p<0.0001. These results were verified for protein (R = 0.939, p = 0.018 and mRNA expression (R = 0.959, p = 0.011 in 5 pancreatic cancer cell lines. RegIV mRNA and protein expression was decreased (94.7±0.3%, 84.1±0.5%; respectively when GLI1 was knocked down (82.1±3.2%, 76.7±2.2%; respectively by the RNAi technique. GLI1 overexpression in mRNA and protein level (924.5±5.3%, 362.1±3.5%; respectively induced RegIV overexpression (729.1±4.3%, 339.0±3.7%; respectively. Moreover, CHIP and EMSA assays showed GLI1 protein bound to RegIV promotor regions (GATCATCCA in pancreatic cancer cells.GLI1 promotes RegIV transcription by binding to the RegIV gene promoter in pancreatic cancer.

75 FR 54226 - Proposed Collection; Comment Request for Notice 98-52 and REG-108639-99

Science.gov (United States)

2010-09-03

... Notice 98-52 and REG- 108639-99 AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and... proposed rulemaking, REG-108639-99, Retirement Plans; Cash or Deferred Arrangements Under Section 401(k.... Regulation Project Number: REG-108639-99. Abstract: This notice provides guidance to plan administrators...

Reg Gene Expression in Periosteum after Fracture and Its In Vitro Induction Triggered by IL-6

Directory of Open Access Journals (Sweden)

Yasuaki Tohma

2017-10-01

Full Text Available The periosteum is a thin membrane that surrounds the outer surface of bones and participates in fracture healing. However, the molecular signals that trigger/initiate the periosteal reaction are not well established. We fractured the rat femoral bone at the diaphysis and fixed it with an intramedullary inserted wire, and the expression of regenerating gene (Reg I, which encodes a tissue regeneration/growth factor, was analyzed. Neither bone/marrow nor muscle showed Reg I gene expression before or after the fracture. By contrast, the periosteum showed an elevated expression after the fracture, thereby confirming the localization of Reg I expression exclusively in the periosteum around the fractured areas. Expression of the Reg family increased after the fracture, followed by a decrease to basal levels by six weeks, when the fracture had almost healed. In vitro cultures of periosteal cells showed no Reg I expression, but the addition of IL-6 significantly induced Reg I gene expression. The addition of IL-6 also increased the cell number and reduced pro-apoptotic gene expression of Bim. The increased cell proliferation and reduction in Bim gene expression were abolished by transfection with Reg I siRNA, indicating that these IL-6-dependent effects require the Reg I gene expression. These results indicate the involvement of the IL-6/Reg pathway in the osteogenic response of the periosteum, which leads to fracture repair.

Reg proteins and their roles in inflammation and cancer of the human digestive system.

Science.gov (United States)

Zhao, Jie; Wang, Jingyu; Wang, Hao; Lai, Maode

2013-01-01

The regenerating gene (Reg) family is a group of small molecules that includes four members found in various species, although only three are found in human tissues. Their expression is stimulated by certain growth factors or cytokines. The Reg family plays different roles in proliferation, migration, and anti-apoptosis through activating different signaling pathways. Their dysexpression is closely associated with a number of human conditions and diseases such as inflammation and cancer, especially in the human digestive system. Clinically, upregulation of Reg proteins is usually demonstrated in histological sections and sera from cancer patients. Therefore, Reg proteins can predict the progression and prognosis of cancers, especially those of the digestive tract, and can also act as diagnostic markers and therapeutic targets.

RegPredict: an integrated system for regulon inference in prokaryotes by comparative genomics approach

Energy Technology Data Exchange (ETDEWEB)

Novichkov, Pavel S.; Rodionov, Dmitry A.; Stavrovskaya, Elena D.; Novichkova, Elena S.; Kazakov, Alexey E.; Gelfand, Mikhail S.; Arkin, Adam P.; Mironov, Andrey A.; Dubchak, Inna

2010-05-26

RegPredict web server is designed to provide comparative genomics tools for reconstruction and analysis of microbial regulons using comparative genomics approach. The server allows the user to rapidly generate reference sets of regulons and regulatory motif profiles in a group of prokaryotic genomes. The new concept of a cluster of co-regulated orthologous operons allows the user to distribute the analysis of large regulons and to perform the comparative analysis of multiple clusters independently. Two major workflows currently implemented in RegPredict are: (i) regulon reconstruction for a known regulatory motif and (ii) ab initio inference of a novel regulon using several scenarios for the generation of starting gene sets. RegPredict provides a comprehensive collection of manually curated positional weight matrices of regulatory motifs. It is based on genomic sequences, ortholog and operon predictions from the MicrobesOnline. An interactive web interface of RegPredict integrates and presents diverse genomic and functional information about the candidate regulon members from several web resources. RegPredict is freely accessible at http://regpredict.lbl.gov.

The labelling of Nanocoll[reg] with [111In] for dual-isotope scanning

International Nuclear Information System (INIS)

Mitterhauser, Markus; Wadsak, Wolfgang; Key Mien, Leonhard-; Eidherr, Harald; Roka, Sebastian; Zettinig, Georg; Angelberger, Peter; Viernstein, Helmut; Kletter, Kurt; Dudczak, Robert

2003-01-01

Visualization and biopsy of sentinel lymph nodes play an important role in planning and controlling the therapy of breast cancer. Hitherto two methods--scintigraphy or gamma probe detection after injection of [ 99m Tc]-nanocolloids and visual detection after injection of patent blue dye--are used routinely. There are no conclusive publications elucidating such important parameters as injection site, injection method and colloidal parameters. The present work aims to label Nanocoll[reg] with [ 111 In] to provide an alternative method, a simultaneous one-compound dual-isotope application. Methods: [ 111 In]-Indiumchloride was buffered with acetate and transferred to the nanocolloid. The colloid labelling reaction was complete after 30 min and filtrated through 100 nm Nuclepore[reg] filters. Results: Incorporation yield of [ 111 In]-Indium into the nanocolloid was nearly quantitative, the step associated with the major loss of activity was the particle sizing with a mean yield of 55%. Conclusion: The presented method allows for the routine supply of [ 111 In]-nanocolloids. Size-filtered [ 111 In]-Nanocoll[reg] shows the same particle size range as [ 99m Tc]-Nanocoll[reg

从FinTech到RegTech

Institute of Scientific and Technical Information of China (English)

孙国峰[1,2

2017-01-01

本文分析FinTech（金融科技）监管的必要性，并介绍了FinTech监管的国际经验，在此基础上提出了我国可以探索将人工智能应用于金融监管，即以RegTech（监管科技）应对FinTech的建议。

Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection.

Directory of Open Access Journals (Sweden)

John David Spencer

Full Text Available Recent evidence indicates that antimicrobial peptides (AMPs serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain.

Expression and Significance of the HIP/PAP and RegIIIγ Antimicrobial Peptides during Mammalian Urinary Tract Infection

Science.gov (United States)

Spencer, John David; Jackson, Ashley R.; Li, Birong; Ching, Christina B.; Vonau, Martin; Easterling, Robert S.; Schwaderer, Andrew L.; McHugh, Kirk M.; Becknell, Brian

2015-01-01

Recent evidence indicates that antimicrobial peptides (AMPs) serve key roles in defending the urinary tract against invading uropathogens. To date, the individual contribution of AMPs to urinary tract host defense is not well defined. In this study, we identified Regenerating islet-derived 3 gamma (RegIIIγ) as the most transcriptionally up-regulated AMP in murine bladder transcriptomes following uropathogenic Escherichia coli (UPEC) infection. We confirmed induction of RegIIIγ mRNA during cystitis and pyelonephritis by quantitative RT-PCR. Immunoblotting demonstrates increased bladder and urinary RegIIIγ protein levels following UPEC infection. Immunostaining localizes RegIIIγ protein to urothelial cells of infected bladders and kidneys. Human patients with UTI have increased urine concentrations of the orthologous Hepatocarcinoma-Intestine-Pancreas / Pancreatitis Associated Protein (HIP/PAP) compared to healthy controls. Recombinant RegIIIγ protein does not demonstrate bactericidal activity toward UPEC in vitro, but does kill Staphylococcus saprophyticus in a dose-dependent manner. Kidney and bladder tissue from RegIIIγ knockout mice and wild-type mice contain comparable bacterial burden following UPEC and Gram-positive UTI. Our results demonstrate that RegIIIγ and HIP/PAP expression is induced during human and murine UTI. However, their specific function in the urinary tract remains uncertain. PMID:26658437

An implementation of SAS reg-sign in an environmental information system

International Nuclear Information System (INIS)

James, T.; Zygmunt, B.C.

1994-01-01

This paper describes a software environmental database information system that uses SAS to process data and ORACLE reg-sign as the relational database management system (RDBMS). The hardware includes a network of UNIX-based servers and workstations. The relational database consists of large tables containing envionmental measurement data, as well as other smaller tables with reference, metadata and internal administrative information. The data come in a variety of formats and must be converted to conform to the system's standards. SAS/ACCESS reg-sign and PROC SQL are used extensively in the data processing

RegTransBase - A Database Of Regulatory Sequences and Interactionsin a Wide Range of Prokaryotic Genomes

Energy Technology Data Exchange (ETDEWEB)

Kazakov, Alexei E.; Cipriano, Michael J.; Novichkov, Pavel S.; Minovitsky, Simon; Vinogradov, Dmitry V.; Arkin, Adam; Mironov, AndreyA.; Gelfand, Mikhail S.; Dubchak, Inna

2006-07-01

RegTransBase, a manually curated database of regulatoryinteractions in prokaryotes, captures the knowledge in publishedscientific literature using a controlled vocabulary. Although a number ofdatabases describing interactions between regulatory proteins and theirbinding sites are currently being maintained, they focus mostly on themodel organisms Escherichia coli and Bacillus subtilis, or are entirelycomputationally derived. RegTransBase describes a large number ofregulatory interactions reported in many organisms and contains varioustypes of experimental data, in particular: the activation or repressionof transcription by an identified direct regulator; determining thetranscriptional regulatory function of a protein (or RNA) directlybinding to DNA (RNA); mapping or prediction of binding site for aregulatory protein; characterization of regulatory mutations. Currently,the RegTransBase content is derived from about 3000 relevant articlesdescribing over 7000 experiments in relation to 128 microbes. It containsdata on the regulation of about 7500 genes and evidence for 6500interactions with 650 regulators. RegTransBase also contains manuallycreated position weight matrices (PWM) that can be used to identifycandidate regulatory sites in over 60 species. RegTransBase is availableat http://regtransbase.lbl.gov.

IMHEX{sup {reg_sign}} fuel cells progress toward commercialization

Energy Technology Data Exchange (ETDEWEB)

Scroppo, J.A.; Laurens, R.M.; Petraglia, V.J.

1995-12-31

The overall goal of M-C Power is the development and subsequent commercialization of Molten Carbonate Fuel Cell (MCFC) stacks. More specifically, MCFC`s Manifolded Heat Exchange (IMHEX{sup {reg_sign}}) plate design created by the Institute of Technology. In order to achieve the aforementioned goal, M-C Power assembled a formidable team of industry leaders. This group, refered to as the (IHMEX{sup {reg_sign}}) Team, has developed a strategy to move decisively through the stages of Technology Development and Product Design and Improvement through commercialization. This paper is to review the status of the overall commercialization program and activities. It will also provide an overview of the market entry product. Furthermore, we will evaluate the opportunities and benefits this product brings to a competitive power industry.

Stage-specific hypermutability of the regA locus of Volvox, a gene regulating the germ-soma dichotomy

International Nuclear Information System (INIS)

Kirk, D.L.; Baran, G.J.; Harper, J.F.; Huskey, R.J.; Huson, K.S.; Zagris, N.

1987-01-01

Mutation at the regA locus confers on somatic cells of Volvox (which otherwise undergo programmed death) ability to redifferentiate as reproductive cells. Stable mutations at the regA locus, but not at other loci, were induced at high frequency when embryos at one particular stage were exposed to either UV irradiation, novobiocin, nalidixic acid, bleomycin, 4-hydroxyaminoquinoline-1-oxide, 5-bromodeoxyuridine, or 5-fluorouracil. All treatments led to some mutations that were not expressed until the second generation after treatment. The sensitive period was after somatic and reproductive cells of the next generation had been set apart, but before they had undergone cytodifferentiation. Hypermutability occurs in presumptive reproductive cells (in which regA is normally not expressed) somewhat before regA normally acts in somatic cells. We postulate that hypermutability of regA in the reproductive cells at this time reflects a change of state that the locus undergoes as it is inactivated

Previsões climáticas sazonais sobre o Brasil: avaliação do RegCM3 aninhado no modelo global CPTEC/COLA Seasonal climatic forecast over Brazil: evaluation of the RegCM3 model nested to the CPTEC/COLA global model

Directory of Open Access Journals (Sweden)

Rubinei Dorneles Machado

2011-03-01

Full Text Available Este trabalho avalia o desempenho de previsões sazonais do modelo climático regional RegCM3, aninhado ao modelo global CPTEC/COLA. As previsões com o RegCM3 utilizaram 60 km de resolução horizontal num domínio que inclui grande parte da América do Sul. As previsões do RegCM3 e CPTEC/COLA foram avaliadas utilizando as análises de chuva e temperatura do ar do Climate Prediction Center (CPC e National Centers for Enviromental Prediction (NCEP, respectivamente. Entre maio de 2005 e julho de 2007, 27 previsões sazonais de chuva e temperatura do ar (exceto a temperatura do CPTEC/COLA, que possui 26 previsões foram avaliadas em três regiões do Brasil: Nordeste (NDE, Sudeste (SDE e Sul (SUL. As previsões do RegCM3 também foram comparadas com as climatologias das análises. De acordo com os índices estatísticos (bias, coeficiente de correlação, raiz quadrada do erro médio quadrático e coeficiente de eficiência, nas três regiões (NDE, SDE e SUL a chuva sazonal prevista pelo RegCM3 é mais próxima da observada do que a prevista pelo CPTEC/COLA. Além disto, o RegCM3 também é melhor previsor da chuva sazonal do que da média das observações nas três regiões. Para temperatura, as previsões do RegCM3 são superiores às do CPTEC/COLA nas áreas NDE e SUL, enquanto o CPTEC/COLA é superior no SDE. Finalmente, as previsões de chuva e temperatura do RegCM3 são mais próximas das observações do que a climatologia observada. Estes resultados indicam o potencial de utilização do RegCM3 para previsão sazonal, que futuramente deverá ser explorado através de previsão por conjunto.This study presents an assessment of seasonal forecasts from the regional climate model RegCM3 nested to the CPTEC/COLA global model. The used RegCM3 version is 60 km horizontal resolution over an area that includes large part of South America. RegCM3 and CPTEC/COLA forecasts were evaluated using the rainfall and air temperature analyses from Climate

Rosebud syncoal partnership SynCoal{sup {reg_sign}} demonstration technology development update

Energy Technology Data Exchange (ETDEWEB)

Sheldon, R.W. [Rosebud SynCoal Company, Billings, MT (United States); Heintz, S.J. [Department of Energy, Pittsburgh, PA (United States)

1995-12-01

Rosebud SynCoal{reg_sign} Partnership`s Advanced Coal Conversion Process (ACCP) is an advanced thermal coal upgrading process coupled with physical cleaning techniques to upgrade high moisture, low-rank coals to produce a high-quality, low-sulfur fuel. The coal is processed through two vibrating fluidized bed reactors where oxygen functional groups are destroyed removing chemically bound water, carboxyl and carbonyl groups, and volatile sulfur compounds. After thermal upgrading, the SynCoal{reg_sign} is cleaned using a deep-bed stratifier process to effectively separate the pyrite rich ash. The SynCoal{reg_sign} process enhances low-rank western coals with moisture contents ranging from 2555%, sulfur contents between 0.5 and 1.5 %, and heating values between 5,500 and 9,000 Btu/lb. The upgraded stable coal product has moisture contents as low as 1 %, sulfur contents as low as 0.3%, and heating values up to 12,000 Btu/lb.

Buscando sentido para a pesquisa e o ensino de regência verbal : uma abordagem funcional-cognitiva

OpenAIRE

Rodrigues, Tiago de Aguiar

2011-01-01

O conteúdo "regência verbal" tem sido trabalhado sistematicamente em sala de aula como uma simples repetição de regras. Para convencer os alunos a estudar regência, o professor os ensina a decorar uma lista infinda de verbos, com o argumento de que isso é necessário para obter sucesso nos concursos e vestibulares. Regência torna-se, então, sinônimo de decoreba, uma vez que, afora concursos e vestibulares, parece não ter outra finalidade. Assim, consolida-se um abismo entre a teoria escolar e ...

RegRNA: an integrated web server for identifying regulatory RNA motifs and elements

OpenAIRE

Huang, Hsi-Yuan; Chien, Chia-Hung; Jen, Kuan-Hua; Huang, Hsien-Da

2006-01-01

Numerous regulatory structural motifs have been identified as playing essential roles in transcriptional and post-transcriptional regulation of gene expression. RegRNA is an integrated web server for identifying the homologs of regulatory RNA motifs and elements against an input mRNA sequence. Both sequence homologs and structural homologs of regulatory RNA motifs can be recognized. The regulatory RNA motifs supported in RegRNA are categorized into several classes: (i) motifs in mRNA 5′-untra...

Feasibility of integrating other federal information systems into the Global Network of Environment and Technology, GNET{reg_sign}

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-05-01

The Global Environment and Technology Enterprise (GETE) of the Global Environment and Technology Foundation (GETF) has been tasked by the US Department of Energy`s (DOE), Federal Energy Technology Center (FETC) to assist in reducing DOE`s cost for the Global Network of Environment and Technology (GNET{reg_sign}). As part of this task, GETE is seeking federal partners to invest in GNET{reg_sign}. The authors are also seeking FETC`s commitment to serve as GNET`s federal agency champion promoting the system to potential agency partners. This report assesses the benefits of partnering with GNET{reg_sign} and provides recommendations for identifying and integrating other federally funded (non-DOE) environmental information management systems into GNET{reg_sign}.

CoryneRegNet 4.0 – A reference database for corynebacterial gene regulatory networks

Directory of Open Access Journals (Sweden)

Baumbach Jan

2007-11-01

Full Text Available Abstract Background Detailed information on DNA-binding transcription factors (the key players in the regulation of gene expression and on transcriptional regulatory interactions of microorganisms deduced from literature-derived knowledge, computer predictions and global DNA microarray hybridization experiments, has opened the way for the genome-wide analysis of transcriptional regulatory networks. The large-scale reconstruction of these networks allows the in silico analysis of cell behavior in response to changing environmental conditions. We previously published CoryneRegNet, an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks. Initially, it was designed to provide methods for the analysis and visualization of the gene regulatory network of Corynebacterium glutamicum. Results Now we introduce CoryneRegNet release 4.0, which integrates data on the gene regulatory networks of 4 corynebacteria, 2 mycobacteria and the model organism Escherichia coli K12. As the previous versions, CoryneRegNet provides a web-based user interface to access the database content, to allow various queries, and to support the reconstruction, analysis and visualization of regulatory networks at different hierarchical levels. In this article, we present the further improved database content of CoryneRegNet along with novel analysis features. The network visualization feature GraphVis now allows the inter-species comparisons of reconstructed gene regulatory networks and the projection of gene expression levels onto that networks. Therefore, we added stimulon data directly into the database, but also provide Web Service access to the DNA microarray analysis platform EMMA. Additionally, CoryneRegNet now provides a SOAP based Web Service server, which can easily be consumed by other bioinformatics software systems. Stimulons (imported from the database, or uploaded by the user can be analyzed in the context of known

RegA, an AraC-Like Protein, Is a Global Transcriptional Regulator That Controls Virulence Gene Expression in Citrobacter rodentium▿

Science.gov (United States)

Hart, Emily; Yang, Ji; Tauschek, Marija; Kelly, Michelle; Wakefield, Matthew J.; Frankel, Gad; Hartland, Elizabeth L.; Robins-Browne, Roy M.

2008-01-01

Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a signature-tagged mutant library of C. rodentium in mice. One noncolonizing mutant had a single transposon insertion in an open reading frame (ORF) which we designated regA because of its homology to genes encoding members of the AraC family of transcriptional regulators. Deletion of regA in C. rodentium resulted in markedly reduced colonization of the mouse intestine. Examination of lacZ transcriptional fusions using promoter regions of known and putative virulence-associated genes of C. rodentium revealed that RegA strongly stimulated transcription of two newly identified genes located close to regA, which we designated adcA and kfcC. The cloned adcA gene conferred autoaggregation and adherence to mammalian cells to E. coli strain DH5α, and a kfc mutation led to a reduction in the duration of intestinal colonization, but the kfc mutant was far less attenuated than the regA mutant. These results indicated that other genes of C. rodentium whose expression required activation by RegA were required for colonization. Microarray analysis revealed a number of RegA-regulated ORFs encoding proteins homologous to known colonization factors. Transcription of these putative virulence determinants was activated by RegA only in the presence of sodium bicarbonate. Taken together, these results show that RegA is a global regulator of virulence in C. rodentium which activates factors that are required for intestinal colonization. PMID:18765720

RegA, an AraC-like protein, is a global transcriptional regulator that controls virulence gene expression in Citrobacter rodentium.

Science.gov (United States)

Hart, Emily; Yang, Ji; Tauschek, Marija; Kelly, Michelle; Wakefield, Matthew J; Frankel, Gad; Hartland, Elizabeth L; Robins-Browne, Roy M

2008-11-01

Citrobacter rodentium is an attaching and effacing pathogen which causes transmissible colonic hyperplasia in mice. Infection with C. rodentium serves as a model for infection of humans with enteropathogenic and enterohemorrhagic Escherichia coli. To identify novel colonization factors of C. rodentium, we screened a signature-tagged mutant library of C. rodentium in mice. One noncolonizing mutant had a single transposon insertion in an open reading frame (ORF) which we designated regA because of its homology to genes encoding members of the AraC family of transcriptional regulators. Deletion of regA in C. rodentium resulted in markedly reduced colonization of the mouse intestine. Examination of lacZ transcriptional fusions using promoter regions of known and putative virulence-associated genes of C. rodentium revealed that RegA strongly stimulated transcription of two newly identified genes located close to regA, which we designated adcA and kfcC. The cloned adcA gene conferred autoaggregation and adherence to mammalian cells to E. coli strain DH5alpha, and a kfc mutation led to a reduction in the duration of intestinal colonization, but the kfc mutant was far less attenuated than the regA mutant. These results indicated that other genes of C. rodentium whose expression required activation by RegA were required for colonization. Microarray analysis revealed a number of RegA-regulated ORFs encoding proteins homologous to known colonization factors. Transcription of these putative virulence determinants was activated by RegA only in the presence of sodium bicarbonate. Taken together, these results show that RegA is a global regulator of virulence in C. rodentium which activates factors that are required for intestinal colonization.

STARPOWER: An IMAX reg-sign Film on Fusion

International Nuclear Information System (INIS)

Kirsch, J.W.

1995-01-01

The Reuben H. Fleet Space Theater and Science Center and Four Square Productions, Inc. are producing STARPOWER, a new IMAX/OMNIMAX reg-sign film about thermonuclear fusion. The film's storyline will link our understanding of fusion as the power source of the stars with our current quest to develop a practical machine that uses fusion to produce electric power. The goal is to reach the world-wide audience of 40,000,000 people who visit IMAX/OMNIMAX reg-sign theaters each year, about half of which are in the United States and Canada. This document is the final report on a project to research and develop the concept. It was supported by grants from the Department of Energy (Museum Science Education Program), the International Space Theater Consortium (ISTC's Film Development Fund), and contributions by the Fleet Center and Four Square Productions. The report describes the development of the film's educational objectives, findings on the current state of fusion research, film treatments and marketing research for the project, preparation of the project prospectus, and planned next steps

Pilot test of Pickliq{reg_sign} process to determine energy and environmental benefits & economic feasibility

Energy Technology Data Exchange (ETDEWEB)

Olsen, D.R.

1997-07-13

Green Technology Group (GTG) was awarded Grant No. DE-FG01-96EE 15657 in the amount of $99,904 for a project to advance GTG`s Pickliq{reg_sign} Process in the Copper and Steel Industries. The use of the Pickliq{reg_sign} Process can significantly reduce the production of waste acids containing metal salts. The Pickliq{reg_sign} Process can save energy and eliminate hazardous waste in a typical copper rod or wire mill or a typical steel wire mill. The objective of this pilot project was to determine the magnitude of the economic, energy and environmental benefits of the Pickliq{reg_sign} Process in two applications within the metal processing industry. The effectiveness of the process has already been demonstrated at facilities cleaning iron and steel with sulfuric acid. 9207 companies are reported to use sulfuric and hydrochloric acid in the USA. The USEPA TRI statistics of acid not recycled in the US is 2.4 x 10{sup 9} lbs (net) for Hydrochloric Acid and 2.0 x 10{sup 9} lbs (net) for Sulfuric Acid. The energy cost of not reclaiming acid is 10.7 x 10{sup 6} BTU/ton for Hydrochloric Acid and 21.6 x 10{sup 6} BTU/Ton for Sulfuric Acid. This means that there is a very large market for the application of the Pickliq{reg_sign} Process and the widespread use of the process will bring significant world wide savings of energy to the environment.

NANoREG framework for the safety assessment of nanomaterials

OpenAIRE

Gottardo, Stefania; Alessandrelli, Maria; Amenta, Valeria; Atluri, Rambabu; Barberio, Grazia; Bekker, Cindy; Bergonzo, Philippe; Bleeker, Eric; Booth, Andy; Borges, Teresa; Buttol, Patrizia; Carlander, David; Castelli, Stefano; Chevillard, Sylvie

2017-01-01

The NANoREG framework addresses the need to ease the nanomaterials safety assessment in the REACH Regulation context. It offers forward-looking strategies: Safe-by-Design, a Nanospecific Prioritisation and Risk Assessment, and Life Cycle Assessment. It is intended for scientific experts, regulatory authorities and industry.

Description and evaluation of the Earth System Regional Climate Model (RegCM-ES)

Science.gov (United States)

Farneti, Riccardo; Sitz, Lina; Di Sante, Fabio; Fuentes-Franco, Ramon; Coppola, Erika; Mariotti, Laura; Reale, Marco; Sannino, Gianmaria; Barreiro, Marcelo; Nogherotto, Rita; Giuliani, Graziano; Graffino, Giorgio; Solidoro, Cosimo; Giorgi, Filippo

2017-04-01

The increasing availability of satellite remote sensing data, of high temporal frequency and spatial resolution, has provided a new and enhanced view of the global ocean and atmosphere, revealing strong air-sea coupling processes throughout the ocean basins. In order to obtain an accurate representation and better understanding of the climate system, its variability and change, the inclusion of all mechanisms of interaction among the different sub-components, at high temporal and spatial resolution, becomes ever more desirable. Recently, global coupled models have been able to progressively refine their horizontal resolution to attempt to resolve smaller-scale processes. However, regional coupled ocean-atmosphere models can achieve even finer resolutions and provide additional information on the mechanisms of air-sea interactions and feedbacks. Here we describe a new, state-of-the-art, Earth System Regional Climate Model (RegCM-ES). RegCM-ES presently includes the coupling between atmosphere, ocean, land surface and sea-ice components, as well as an hydrological and ocean biogeochemistry model. The regional coupled model has been implemented and tested over some of the COordinated Regional climate Downscaling Experiment (CORDEX) domains. RegCM-ES has shown improvements in the representation of precipitation and SST fields over the tested domains, as well as realistic representations of coupled air-sea processes and interactions. The RegCM-ES model, which can be easily implemented over any regional domain of interest, is open source making it suitable for usage by the large scientific community.

CoryneRegNet: an ontology-based data warehouse of corynebacterial transcription factors and regulatory networks.

Science.gov (United States)

Baumbach, Jan; Brinkrolf, Karina; Czaja, Lisa F; Rahmann, Sven; Tauch, Andreas

2006-02-14

The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions. CoryneRegNet was designed to facilitate the genome-wide reconstruction of transcriptional regulatory networks of corynebacteria relevant in biotechnology and human medicine. During the import and integration process of data derived from experimental studies or literature knowledge CoryneRegNet generates links to genome annotations, to identified transcription factors and to the corresponding cis-regulatory elements. CoryneRegNet is based on a multi-layered, hierarchical and modular concept of transcriptional regulation and was implemented by using the relational database management system MySQL and an ontology-based data structure. Reconstructed regulatory networks can be visualized by using the yFiles JAVA graph library. As an application example of CoryneRegNet, we have reconstructed the global transcriptional regulation of a cellular module involved in SOS and stress response of corynebacteria. CoryneRegNet is an ontology-based data warehouse that allows a pertinent data management of regulatory interactions along with the genome-scale reconstruction of transcriptional regulatory networks. These models can further be combined with metabolic networks to build integrated models of cellular function including both metabolism and its transcriptional regulation.

Bicarbonate-mediated transcriptional activation of divergent operons by the virulence regulatory protein, RegA, from Citrobacter rodentium.

Science.gov (United States)

Yang, Ji; Hart, Emily; Tauschek, Marija; Price, G Dean; Hartland, Elizabeth L; Strugnell, Richard A; Robins-Browne, Roy M

2008-04-01

Regulation of virulence gene expression plays a central role in the pathogenesis of enteric bacteria as they encounter diverse environmental conditions in the gastrointestinal tract of their hosts. In this study, we investigated environmental regulation of two putative virulence determinants adcA and kfc by RegA, an AraC/XylS-like regulator, from Citrobacter rodentium, and identified bicarbonate as the environmental signal which induced transcription of adcA and kfc through RegA. Primer extension experiments showed that adcA and kfc were divergently transcribed from sigma(70) promoters. In vivo and in vitro experiments demonstrated that bicarbonate facilitated and stabilized the binding of RegA to an operator located between the two promoters. The interaction of RegA with its DNA target resulted in the formation of a nucleosome-like structure, which evidently displaced the histone-like proteins, H-NS and StpA, from the adcA and kfc promoter regions, leading to transcriptional derepression. In addition, our results indicated that RegA also behaved as a Class I activator by directly stimulating transcription initiation by RNA polymerase. This is the first report to describe the molecular mechanism by which an environmental chemical stimulates transcription of virulence-associated genes of an enteric pathogen through an AraC/XlyS-like activator.

The efficacy of Xialine[reg] in patients with xerostomia resulting from radiotherapy for head and neck cancer: a pilot-study

International Nuclear Information System (INIS)

Jellema, Anke Petra; Langendijk, Hans; Bergenhenegouwen, Lester; Reijden, Willy van der; Leemans, Rene; Smeele, Ludy; Slotman, Berend J.

2001-01-01

Changes in subjective sensations due to xerostomia before and after administration of Xialine [reg] , a xanthan gum-based saliva substitute, were evaluated in 30 patients with radiation-induced xerostomia using the QLQ-H and N35. Xerostomia in general decreased with both Xialine [reg] and placebo to almost the same degree. A trend was seen for Xialine [reg] to improve problems with speech and senses

CoryneRegNet: An ontology-based data warehouse of corynebacterial transcription factors and regulatory networks

Directory of Open Access Journals (Sweden)

Czaja Lisa F

2006-02-01

Full Text Available Abstract Background The application of DNA microarray technology in post-genomic analysis of bacterial genome sequences has allowed the generation of huge amounts of data related to regulatory networks. This data along with literature-derived knowledge on regulation of gene expression has opened the way for genome-wide reconstruction of transcriptional regulatory networks. These large-scale reconstructions can be converted into in silico models of bacterial cells that allow a systematic analysis of network behavior in response to changing environmental conditions. Description CoryneRegNet was designed to facilitate the genome-wide reconstruction of transcriptional regulatory networks of corynebacteria relevant in biotechnology and human medicine. During the import and integration process of data derived from experimental studies or literature knowledge CoryneRegNet generates links to genome annotations, to identified transcription factors and to the corresponding cis-regulatory elements. CoryneRegNet is based on a multi-layered, hierarchical and modular concept of transcriptional regulation and was implemented by using the relational database management system MySQL and an ontology-based data structure. Reconstructed regulatory networks can be visualized by using the yFiles JAVA graph library. As an application example of CoryneRegNet, we have reconstructed the global transcriptional regulation of a cellular module involved in SOS and stress response of corynebacteria. Conclusion CoryneRegNet is an ontology-based data warehouse that allows a pertinent data management of regulatory interactions along with the genome-scale reconstruction of transcriptional regulatory networks. These models can further be combined with metabolic networks to build integrated models of cellular function including both metabolism and its transcriptional regulation.

Spent nuclear fuel application of CORE reg-sign systems engineering software

International Nuclear Information System (INIS)

Grimm, R.J.

1996-01-01

The DOE has adopted a systems engineering approach for the successful completion of the Spent Nuclear Fuel (SNF) Program mission. The DOE has utilized systems engineering principles to develop the SNF program guidance documents and has held several systems engineering workshops to develop the functional hierarchies of both the programmatic and technical side of the SNF program. The sheer size and complexity of the SNF program has led to problems that the Westinghouse Savannah River Company (WSRC) is working to manage through the use of systems engineering software. WSRC began using CORE reg-sign, an off the shelf PC based software package, to assist DOE in management of the SNF program. This paper details the successful use of the CORE reg-sign systems engineering software to date and the proposed future activities

The Reg1-interacting proteins, Bmh1, Bmh2, Ssb1, and Ssb2, have roles in maintaining glucose repression in Saccharomyces cerevisiae.

Science.gov (United States)

Dombek, Kenneth M; Kacherovsky, Nataly; Young, Elton T

2004-09-10

In Saccharomyces cerevisiae, a type 1 protein phosphatase complex composed of the Glc7 catalytic subunit and the Reg1 regulatory subunit represses expression of many glucose-regulated genes. Here we show that the Reg1-interacting proteins Bmh1, Bmh2, Ssb1, and Ssb2 have roles in glucose repression. Deleting both BMH genes causes partially constitutive ADH2 expression without significantly increasing the level of Adr1 protein, the major activator of ADH2 expression. Adr1 and Bcy1, the regulatory subunit of cAMP-dependent protein kinase, are both required for this effect indicating that constitutive expression in Deltabmh1Deltabmh2 cells uses the same activation pathway that operates in Deltareg1 cells. Deletion of both BMH genes and REG1 causes a synergistic relief from repression, suggesting that Bmh proteins also act independently of Reg1 during glucose repression. A two-hybrid interaction with the Bmh proteins was mapped to amino acids 187-232, a region of Reg1 that is conserved in different classes of fungi. Deleting this region partially releases SUC2 from glucose repression. This indicates a role for the Reg1-Bmh interaction in glucose repression and also suggests a broad role for Bmh proteins in this process. An in vivo Reg1-Bmh interaction was confirmed by copurification of Bmh proteins with HA(3)-TAP-tagged Reg1. The nonconventional heat shock proteins Ssb1 and Ssb2 are also copurified with HA(3)-TAP-tagged Reg1. Deletion of both SSB genes modestly decreases repression of ADH2 expression in the presence of glucose, suggesting that Ssb proteins, perhaps through their interaction with Reg1, play a minor role in glucose repression.

The Regional Earth System Model (RegESM) using RegCM4 coupled with the MITgcm ocean model: First assessments over the MED-CORDEX domain

Science.gov (United States)

Mariotti, Laura; Utku Turunçoǧlu, Ufuk; Farneti, Riccardo; Sannino, Gianmaria; Vittoria Struglia, Maria; Carillo, Adriana; Giorgi, Filippo

2016-04-01

In the framework of global climate studies, there is an increasingly growing concern about the vulnerability of the Mediterranean region, where high population density and intense exploitation activities pose severe questions on the sustainability of terrestrial water management, both for the present and the future. Ocean modeling studies suggest that the Mediterranean thermohaline circulation could be weakened in conditions of global greenhouse warming, an event which would undoubtedly affect regional climate, possibly triggering global feedback processes. Experiments with the atmosphere-ocean coupled system confirmed that a good comprehension of Mediterranean processes requires the explicit inclusion of the feedbacks between the atmospheric and the oceanic components, thus achieving a complete, fully coupled description of the Mediterranean hydrological cycle, at the same time gaining new insights in our current ability to reproduce the atmospheric hydrological processes and to close the hydrological balance. These issues are addressed by the upgraded PROTHEUS system which was jointly developed by ENEA and ICTP. Here we present a first evaluation of the performances of the new PROTHEUS system (called PROTHEUS 2.0) composed by the regional climate model RegCM4 (Giorgi et al. 2012) coupled with both the ocean model MITgcm (Marshall J. et al. 1997a,b) and the HD river model (Max-Planck's HD model; Hagemann and Dümenil, 1998) using RegESM (Regional Earth System Model) as a driver. The three-component (atmosphere, ocean and river routing) fully coupled model exchanges sea surface temperature (SST) from the ocean to the atmospheric model, surface wind stress, energy and freshwater fluxes from the atmosphere to the ocean model, surface and sub-surface runoff from the atmospheric component to the river routing model (Max-Planck's HD model; Hagemann and Dümenil, 1998). In order to have water conservation within the system, the river routing component sends the

RegPrecise 3.0--a resource for genome-scale exploration of transcriptional regulation in bacteria.

Science.gov (United States)

Novichkov, Pavel S; Kazakov, Alexey E; Ravcheev, Dmitry A; Leyn, Semen A; Kovaleva, Galina Y; Sutormin, Roman A; Kazanov, Marat D; Riehl, William; Arkin, Adam P; Dubchak, Inna; Rodionov, Dmitry A

2013-11-01

Genome-scale prediction of gene regulation and reconstruction of transcriptional regulatory networks in prokaryotes is one of the critical tasks of modern genomics. Bacteria from different taxonomic groups, whose lifestyles and natural environments are substantially different, possess highly diverged transcriptional regulatory networks. The comparative genomics approaches are useful for in silico reconstruction of bacterial regulons and networks operated by both transcription factors (TFs) and RNA regulatory elements (riboswitches). RegPrecise (http://regprecise.lbl.gov) is a web resource for collection, visualization and analysis of transcriptional regulons reconstructed by comparative genomics. We significantly expanded a reference collection of manually curated regulons we introduced earlier. RegPrecise 3.0 provides access to inferred regulatory interactions organized by phylogenetic, structural and functional properties. Taxonomy-specific collections include 781 TF regulogs inferred in more than 160 genomes representing 14 taxonomic groups of Bacteria. TF-specific collections include regulogs for a selected subset of 40 TFs reconstructed across more than 30 taxonomic lineages. Novel collections of regulons operated by RNA regulatory elements (riboswitches) include near 400 regulogs inferred in 24 bacterial lineages. RegPrecise 3.0 provides four classifications of the reference regulons implemented as controlled vocabularies: 55 TF protein families; 43 RNA motif families; ~150 biological processes or metabolic pathways; and ~200 effectors or environmental signals. Genome-wide visualization of regulatory networks and metabolic pathways covered by the reference regulons are available for all studied genomes. A separate section of RegPrecise 3.0 contains draft regulatory networks in 640 genomes obtained by an conservative propagation of the reference regulons to closely related genomes. RegPrecise 3.0 gives access to the transcriptional regulons reconstructed in

Comparison of plastic and orfit[reg] masks for patient head fixation during radiotherapy: precision and costs

International Nuclear Information System (INIS)

Weltens, Caroline; Kesteloot, Katrien; Vandevelde, Guy; Van den Bogaert, Walter

1995-01-01

Purpose: Two widely used immobilization systems for head fixation during radiotherapy treatment for ear-nose-throat (ENT) tumors are evaluated. Methods and Materials: Masks made of poly vinyl-chloride (plastuc) are compared to thermoplastic masks (Orfit[reg]) with respect to the accuracy of the treatment setup and the costs. For both types of material, a cut-out (windows corresponding to treatment fields) and a full mask (not cut out) are considered. Forty-three patients treated for ENT tumors were randomized into four groups, to be fixed by one of the following modalities: cut-out plastic mask (12 patients), full plastic mask (11 patients), cut-out Orfit[reg] mask (10 patients), and full Orfit[reg] mask (10 patients). Results: Reproducibility of the treatment setup was assessed by calculating the deviations from the mean value for each individual patient and was demonstrated to be identical for all subgroups: no differences were demonstrated between the plastic (s = 2.1 mm) and the Orfit[reg] (s = 2.1 mm) group nor between the cut-out (s = 2.0 mm) and not cut-out (s = 2.1 mm) group. The transfer chain from simulator to treatment unit was checked by comparing portal images to their respective simulation image, and no differences between the four subgroups (s = ±3.5 mm) could be detected. A methodology was described to compare the costs of both types of masks, and illustrated with the data for a department. It was found that Orfit[reg] masks are a cheaper alternative than plastic masks; they require much less investment expenses and the workload and material cost of the first mask for each patient is also lower. Cut-out masks are more expensive than full masks, because of the higher workload and the additional material required for second and third masks that are required in case of field modifications. Conclusions: No substantial difference in patient setup accuracy between both types of masks was detected, and cutting out the masks had no impact on the fixing

Spent nuclear fuel application of CORE reg-sign systems engineering software

International Nuclear Information System (INIS)

Grimm, R.J.

1996-01-01

The Department of Energy (DOE) has adopted a systems engineering approach for the successful completion of the Spent Nuclear Fuel (SNF) Program mission. The DOE has utilized systems engineering principles to develop the SNF Program guidance documents and has held several systems engineering workshops to develop the functional hierarchies of both the programmatic and technical side of the SNF Program. The sheer size and complexity of the SNF Program, however, has led to problems that the Westinghouse Savannah River Company (WSRC) is working to manage through the use of systems engineering software. WSRC began using CORE reg-sign, an off-the-shelf PC based software package, to assist the DOE in management of the SNF program. This paper details the successful use of the CORE reg-sign systems engineering software to date and the proposed future activities

The regional climate model RegCM3 performances over several regions and climate regimes

Science.gov (United States)

Coppola, E.; Rauscher, S.; Gao, X.; Giorgi, F.; Im, E. S.; Mariotti, L.; Seth, A.; Sylla, M. B.

2009-04-01

Regional Climate models are more and more needed to provide high resolution regional climate information in climate impact studies. Water availability in a future scenario is the main request of policy makers for adaptation and mitigation purposes. However precipitation changes are unlikely to be as spatially coherent as temperature changes and they are closely related to the regional model itself. In addition model skill varies regionally. An example of several ICTP regional climate model (RegCM3) simulations is reported over China, Korea, Africa, Central and Southern America, Europe and Australia. Over China, Australia, and Korea the regional model improves the simulation compared to the driving GCM when compared with CRU observations. In China, for example, the higher resolution of the regional model inhibits the penetration of the monsoon precipitation front from the southern slope of the Himalaya onto the Tibetan Plateau. In Korea the nested domain simulation (20 km) shows an encouraging performance with regard to capturing extreme precipitation episodes and the finer spatial distribution reflects the detailed geography of the Korean Peninsula. Over South America, RegCM captures the annual cycle of precipitation over Northeast Brazil and the South American Monsoon region, although the monsoon onset occurs too early in the model. Precipitation over the Amazon is not well captured, with too little precipitation associated with weak easterlies and reduced moisture transport into the interior of the continent. RegCM simulates the annual cycle of precipitation over Central America and the Caribbean fairly well; in particular, the complex spatial distribution of the Mid-Summer Drought, a decrease in precipitation that occurs during the middle of the rainy season in July and August, is better captured by RegCM than by the GCM. In addition, RegCM simulates the strength and position of the Caribbean low level jet, a mesoscale feature related to precipitation anomalies

Rosebud SynCoal Partnership, SynCoal{reg_sign} demonstration technology update

Energy Technology Data Exchange (ETDEWEB)

Sheldon, R.W. [Rosebud SynCoal Partnership, Billings, MT (United States)

1997-12-31

An Advanced Coal Conversion Process (ACCP) technology being demonstrated in eastern Montana (USA) at the heart of one of the world`s largest coal deposits is providing evidence that the molecular structure of low-rank coals can be altered successfully to produce a unique product for a variety of utility and industrial applications. The product is called SynCoal{reg_sign} and the process has been developed by the Rosebud SynCoal Partnership (RSCP) through the US Department of Energy`s multi-million dollar Clean Coal Technology Program. The ACCP demonstration process uses low-pressure, superheated gases to process coal in vibrating fluidized beds. Two vibratory fluidized processing stages are used to heat and convert the coal. This is followed by a water spray quench and a vibratory fluidized stage to cool the coal. Pneumatic separators remove the solid impurities from the dried coal. There are three major steps to the SynCoal{reg_sign} process: (1) thermal treatment of the coal in an inert atmosphere, (2) inert gas cooling of the hot coal, and (3) removal of ash minerals. When operated continuously, the demonstration plant produces over 1,000 tons per day (up to 300,000 tons per year) of SynCoal{reg_sign} with a 2% moisture content, approximately 11,800b Btu/lb and less than 1.0 pound of SO{sub 2} per million Btu. This product is obtained from Rosebud Mine sub-bituminous coal which starts with 25% moisture, 8,600 Btu/lb and approximately 1.6 pounds of SO{sub 2} per million Btu.

Recent development in crystal growth of large-diameter Y-QMG (reg sign) bulk superconductors; Y kei ogata QMG (reg sign) baruku koonchodendotai no kaihatsu jokyo

Energy Technology Data Exchange (ETDEWEB)

Fujimoto, T.; Morita, M. [Nippon Steel Corporation, Tokyo (Japan); Masahashi, N. [Tohoku University, Miyagi (Japan). Institute for Materials Research

1999-11-25

The current status of large-diameter Y-Ba-Cu-O OMG(reg sign) bulk superconductors is described. 75 mm-diameter QMG(reg sign) samples with fairly concentric trapped-magnetic-flux-density distributions have been successfully grown. In addition, a record-high value of the magnetic levitation force, 171 kgf, measured at 77 K using a 90 mm-diameter Nd-Fe-B magnet has been obtained for a 100 mm-diameter sample. The crystal orientation of subgrains in the sample was determined using Electron Back-Scattering Diffraction as well as using a conventional optical apparatus including a He-Ne-laser. For the sample grown under normal process conditions, the maximum value of the [001]-axis misorientation angles at the subgrain-boundaries we obtained in the c-substructure region is 2.9 degree. However, in the a/b-substructure regions, the misorientation angles are larger, and the maximum value obtained is 6.6 degree, exceeding the critical angle at which a significant reduction of the critical current density occurs in Y123 thin films due to the weak-link problem. (author)

CANDU reg-sign -- A Canadian energy system

International Nuclear Information System (INIS)

Sejnoha, R.

1994-01-01

Uranium is one of Canada's important natural resources. It is perhaps not surprising that a country with such an abundance of uranium developed its own inexpensive, safe, and environmentally friendly system of energy generation, based on uranium: CANDU reg-sign (CANada-Deuterium-Uranium, a registered trademark of AECL). The objective of this paper is to describe briefly the main features of the CANDU system and explain methods used to assure the compatibility with the requirements for a clean and safe environment. The paper describes the CANDU reactor, and discusses storage of spent fuel, reactor performance, normal operating conditions, safety under accident conditions, and quality assurance in design, manufacturing, and operation

Topical safety analysis report for the transportation of the NUHOMS reg-sign dry shielded canister

International Nuclear Information System (INIS)

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS reg-sign) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS reg-sign DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS reg-sign Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport

Impact of the reg1 mutation glycocen accumulation and glucose consumption rates in Saccharomyces cerevisiae cells based on a macrokinetic model

Directory of Open Access Journals (Sweden)

Rocha-Leão M.H.M.

2003-01-01

Full Text Available In S. cerevisiae, catabolite repression controls glycogen accumulation and glucose consumption. Glycogen is responsible for stress resistance, and its accumulation in derepression conditions results in a yeast with good quality. In yeast cells, catabolite repression also named glucose effect takes place at the transcriptional levels, decreasing enzyme respiration and causing the cells to enter a fermentative metabolism, low cell mass yield and yeast with poor quality. Since glucose is always present in molasses the glucose effect occurs in industrial media. A quantitative characterization of cell growth, substrate consumption and glycogen formation was undertaken based on an unstructured macrokinetic model for a reg1/hex2 mutant, capable of the respiration while growing on glucose, and its isogenic repressible strain (REG1/HEX2. The results show that the estimated value to maximum specific glycogen accumulation rate (muG,MAX is eight times greater in the reg1/hex2 mutant than its isogenic strain, and the glucose affinity constant (K SS is fifth times greater in reg1/hex2 mutant than in its isogenic strain with less glucose uptake by the former channeling glucose into cell mass growth and glycogen accumulation simultaneously. This approach may be one more tool to improve the glucose removal in yeast production. Thus, disruption of the REG1/HEX2 gene may constitute an important strategy for producing commercial yeast.

On the ability of RegCM4 to simulate surface solar radiation patterns over Europe: An assessment using satellite-based observations

Science.gov (United States)

Alexandri, Georgia; Georgoulias, Aristeidis K.; Zanis, Prodromos; Tsikerdekis, Athanasios; Katragkou, Eleni; Kourtidis, Konstantinos; Meleti, Charikleia

2015-04-01

We assess here the ability of RegCM4 to simulate the surface solar radiation (SSR) patterns over the European domain. For the needs of this work, a decadal (1999-2009) simulation was implemented at a horizontal resolution of 50km using the first year as a spin-up. The model is driven by emissions from CMIP5 while ERA-interim data were used as lateral boundary conditions. The RegCM4 SSR fields were validated against satellite-based SSR observations from Meteosat First Generation (MFG) and Meteosat Second Generation (MSG) sensors (CM SAF SIS product). The RegCM4 simulations slightly overestimate SSR compared to CM SAF over Europe with the bias being +1.54% in case of MFG (2000-2005) and +3.34% in case of MSG (2006-2009). SSR from RegCM4 is much closer to SSR from CM SAF over land (bias of -1.59% for MFG and +0.66% for MSG) than over ocean (bias of +7.20% for MFG and 8.07% for MSG). In order to understand the reasons of this bias, we proceeded to a detailed assessment of various parameters that define the SSR levels (cloud fractional cover - CFC, cloud optical thickness - COT, cloud droplet effective radius - Re, aerosol optical thickness - AOD, asymmetry factor - ASY, single scattering albedo - SSA, water vapor - WV and surface albedo - ALB). We validated the simulated CFC, COT and Re from RegCM4 against satellite-based observations from MSG and we found that RegCM4 significantly underestimates CFC and Re, and overestimates COT over Europe. The aerosol-related parameters from RegCM4 were compared with values from the aerosol climatology taken into account within CM SAF SSR estimates. AOD is significantly underestimated in our simulations which leads to a positive SSR bias. The RegCM4 WV and ALB were compared with WV values from ERA-interim and ALB climatological observations from CERES which are also taken into account within CM SAF SSR estimates. Finally, with the use of a radiative transfer model (SBDART) we manage to quantify the relative contribution of each of

HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease.

Science.gov (United States)

Ward, Lucas D; Kellis, Manolis

2016-01-04

More than 90% of common variants associated with complex traits do not affect proteins directly, but instead the circuits that control gene expression. This has increased the urgency of understanding the regulatory genome as a key component for translating genetic results into mechanistic insights and ultimately therapeutics. To address this challenge, we developed HaploReg (http://compbio.mit.edu/HaploReg) to aid the functional dissection of genome-wide association study (GWAS) results, the prediction of putative causal variants in haplotype blocks, the prediction of likely cell types of action, and the prediction of candidate target genes by systematic mining of comparative, epigenomic and regulatory annotations. Since first launching the website in 2011, we have greatly expanded HaploReg, increasing the number of chromatin state maps to 127 reference epigenomes from ENCODE 2012 and Roadmap Epigenomics, incorporating regulator binding data, expanding regulatory motif disruption annotations, and integrating expression quantitative trait locus (eQTL) variants and their tissue-specific target genes from GTEx, Geuvadis, and other recent studies. We present these updates as HaploReg v4, and illustrate a use case of HaploReg for attention deficit hyperactivity disorder (ADHD)-associated SNPs with putative brain regulatory mechanisms. © The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

Advanced Recyclable Media System reg-sign. Innovative technology summary report

International Nuclear Information System (INIS)

1998-12-01

The objective of the Large-Scale Demonstration Project (LSDP) is to select and demonstrate potentially beneficial technologies at the Argonne National Laboratory East's (ANL) Chicago Pile-5 (CP-5) Research Reactor. The purpose of the LSDP is to demonstrate that using innovative and improved deactivation and decommissioning (D and D) technologies from various sources can result in significant benefits, such as decreased cost and increased health and safety, as compared with baseline D and D technologies. This report describes a demonstration of the Advanced Recyclable Media System reg-sign technology which was employed by Surface Technology Systems, Inc. to remove coatings from a concrete floor. This demonstration is part of the CP-5 LSDP sponsored by the US Department of Energy (DOE) Office of Science and Technology Deactivation and Decommissioning Focus Area (DDFA). The Advanced Recyclable Media System reg-sign (ARMS) technology is an open blast technology which uses a soft recyclable media. The patented ARMS Engineered Blast Media consists of a fiber-reinforced polymer matrix which can be manufactured in various grades of abrasiveness. The fiber media can be remade and/or reused up to 20 times and can clean almost any surface (e.g., metal, wood, concrete, lead) and geometry including corners and the inside of air ducts

Dose area product evaluations with Gafchromic[reg] XR-R films and a flat-bed scanner

International Nuclear Information System (INIS)

Rampado, O; Garelli, E; Deagostini, S; Ropolo, R

2006-01-01

Gafchromic[reg] XR-R films are a useful tool to evaluate entrance skin dose in interventional radiology. Another dosimetric quantity of interest in diagnostic and interventional radiology is the dose area product (DAP). In this study, a method to evaluate DAP using Gafchromic[reg] XR-R films and a flat-bed scanner was developed and tested. Film samples were exposed to an x-ray beam of 80 kVp over a dose range of 0-10 Gy. DAP measurements with films were obtained from the digitalization of a film sample positioned over the x-ray beam window during the exposure. DAP values obtained with this method were compared for 23 cardiological interventional procedures with DAP values displayed by the equipment. The overall one-sigma dose measurement uncertainty depended on the absorbed dose, with values below 6% for doses above 1 Gy. A maximum discrepancy of 16% was found, which is of the order of the differences in the DAP measurements that may occur with different calibration procedures. Based on the results presented, after an accurate calibration procedure and a thorough inspection of the relationship between the actual dose and the direct measured quantity (net optical density or net pixel value variation), Gafchromic[reg] XR-R films can be used to assess the DAP. (note)

Dose area product evaluations with Gafchromic[reg] XR-R films and a flat-bed scanner

Energy Technology Data Exchange (ETDEWEB)

Rampado, O; Garelli, E; Deagostini, S; Ropolo, R [Struttura Complessa Fisica Sanitaria, Azienda Ospedaliera San Giovanni Battista, Corso Bramante 88, 10126 Turin (Italy)

2006-12-07

Gafchromic[reg] XR-R films are a useful tool to evaluate entrance skin dose in interventional radiology. Another dosimetric quantity of interest in diagnostic and interventional radiology is the dose area product (DAP). In this study, a method to evaluate DAP using Gafchromic[reg] XR-R films and a flat-bed scanner was developed and tested. Film samples were exposed to an x-ray beam of 80 kVp over a dose range of 0-10 Gy. DAP measurements with films were obtained from the digitalization of a film sample positioned over the x-ray beam window during the exposure. DAP values obtained with this method were compared for 23 cardiological interventional procedures with DAP values displayed by the equipment. The overall one-sigma dose measurement uncertainty depended on the absorbed dose, with values below 6% for doses above 1 Gy. A maximum discrepancy of 16% was found, which is of the order of the differences in the DAP measurements that may occur with different calibration procedures. Based on the results presented, after an accurate calibration procedure and a thorough inspection of the relationship between the actual dose and the direct measured quantity (net optical density or net pixel value variation), Gafchromic[reg] XR-R films can be used to assess the DAP. (note)

Removal of contaminants from equipment and debris and waste minimization using TechXtract{reg_sign} technology

Energy Technology Data Exchange (ETDEWEB)

Bonem, M.W. [EET, Inc., Bellaire, TX (United States)

1997-10-01

Under this Program Research and Development Agreement (PRDA), EET, Inc., is extending its proprietary TechXtract{reg_sign} chemical decontamination technology into an effective, economical, integrated contaminant removal system. This integrated system will consist of a series of decontamination baths using the TechXtract{reg_sign} chemical formulas, followed by a waste treatment process that will remove the contaminants from the spent chemicals. Sufficient decontamination will result so that materials can be released without restriction after they have been treated, even those materials that have traditionally been considered to be {open_quotes}undecontaminable.{close_quotes} The secondary liquid waste will then be treated to separate any hazardous and radioactive contaminants, so that the spent chemicals and wastewater can be discharged through conventional, permitted outlets. The TechXtract{reg_sign} technology is a unique process that chemically extracts hazardous contaminants from the surface and substrate of concrete, steel, and other solid materials. This technology has been used successfully to remove contaminants as varied as PCBs, radionuclides, heavy metals, and hazardous organics. The process` advantage over other alternatives is its effectiveness in safe and consistent extraction of subsurface contamination. TechXtract{reg_sign} is a proprietary process developed, owned, and provided by EET, Inc. The objective of the PRDA is to demonstrate on a full-scale basis an economical system for decontaminating equipment and debris, with further treatment of secondary waste streams to minimize waste volumes. Contaminants will be removed from the contaminated items to levels where they can be released for unrestricted use. The entire system will be designed with maximum flexibility and automation in mind.

Removal of contaminants from equipment and debris and waste minimization using TechXtract reg-sign technology

International Nuclear Information System (INIS)

Bonem, M.W.

1997-01-01

Under this Program Research and Development Agreement (PRDA), EET, Inc., is extending its proprietary TechXtract reg-sign chemical decontamination technology into an effective, economical, integrated contaminant removal system. This integrated system will consist of a series of decontamination baths using the TechXtract reg-sign chemical formulas, followed by a waste treatment process that will remove the contaminants from the spent chemicals. Sufficient decontamination will result so that materials can be released without restriction after they have been treated, even those materials that have traditionally been considered to be open-quotes undecontaminable.close quotes The secondary liquid waste will then be treated to separate any hazardous and radioactive contaminants, so that the spent chemicals and wastewater can be discharged through conventional, permitted outlets. The TechXtract reg-sign technology is a unique process that chemically extracts hazardous contaminants from the surface and substrate of concrete, steel, and other solid materials. This technology has been used successfully to remove contaminants as varied as PCBs, radionuclides, heavy metals, and hazardous organics. The process' advantage over other alternatives is its effectiveness in safe and consistent extraction of subsurface contamination. TechXtract reg-sign is a proprietary process developed, owned, and provided by EET, Inc. The objective of the PRDA is to demonstrate on a full-scale basis an economical system for decontaminating equipment and debris, with further treatment of secondary waste streams to minimize waste volumes. Contaminants will be removed from the contaminated items to levels where they can be released for unrestricted use. The entire system will be designed with maximum flexibility and automation in mind

RegA Plays a Key Role in Oxygen-Dependent Establishment of Persistence and in Isocitrate Lyase Activity, a Critical Determinant of In vivo Brucella suis Pathogenicity

Directory of Open Access Journals (Sweden)

Elias Abdou

2017-05-01

Full Text Available For aerobic human pathogens, adaptation to hypoxia is a critical factor for the establishment of persistent infections, as oxygen availability is low inside the host. The two-component system RegB/A of Brucella suis plays a central role in the control of respiratory systems adapted to oxygen deficiency, and in persistence in vivo. Using an original “in vitro model of persistence” consisting in gradual oxygen depletion, we compared transcriptomes and proteomes of wild-type and ΔregA strains to identify the RegA-regulon potentially involved in the set-up of persistence. Consecutive to oxygen consumption resulting in growth arrest, 12% of the genes in B. suis were potentially controlled directly or indirectly by RegA, among which numerous transcriptional regulators were up-regulated. In contrast, genes or proteins involved in envelope biogenesis and in cellular division were repressed, suggesting a possible role for RegA in the set-up of a non-proliferative persistence state. Importantly, the greatest number of the RegA-repressed genes and proteins, including aceA encoding the functional IsoCitrate Lyase (ICL, were involved in energy production. A potential consequence of this RegA impact may be the slowing-down of the central metabolism as B. suis progressively enters into persistence. Moreover, ICL is an essential determinant of pathogenesis and long-term interactions with the host, as demonstrated by the strict dependence of B. suis on ICL activity for multiplication and persistence during in vivo infection. RegA regulates gene or protein expression of all functional groups, which is why RegA is a key regulator of B. suis in adaptation to oxygen depletion. This function may contribute to the constraint of bacterial growth, typical of chronic infection. Oxygen-dependent activation of two-component systems that control persistence regulons, shared by several aerobic human pathogens, has not been studied in Brucella sp. before. This work

Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of Mycobacterium tuberculosis.

Directory of Open Access Journals (Sweden)

Gretta Roberts

Full Text Available Two component regulatory systems are used widely by bacteria to coordinate changes in global gene expression profiles in response to environmental signals. The SenX3-RegX3 two component system of Mycobacterium tuberculosis has previously been shown to play a role in virulence and phosphate-responsive control of gene expression. We demonstrate that expression of SenX3-RegX3 is controlled in response to growth conditions, although the absolute changes are small. Global gene expression profiling of a RegX3 deletion strain and wild-type strain in different culture conditions (static, microaerobic, anaerobic, as well as in an over-expressing strain identified a number of genes with changed expression patterns. Among those were genes previously identified as differentially regulated in aerobic culture, including ald (encoding alanine dehydrogenase cyd,encoding a subunit of the cytochrome D ubiquinol oxidase, and gltA1, encoding a citrate synthase. Promoter activity in the upstream regions of both cydB and gltA1 was altered in the RegX3 deletion strain. DNA-binding assays confirmed that RegX3 binds to the promoter regions of ald, cydB and gltA1 in a phosphorylation-dependent manner. Taken together these data suggest a direct role for the SenX-RegX3 system in modulating expression of aerobic respiration, in addition to its role during phosphate limitation.

Simulation and spatiotemporal pattern of air temperature and precipitation in Eastern Central Asia using RegCM.

Science.gov (United States)

Meng, Xianyong; Long, Aihua; Wu, Yiping; Yin, Gang; Wang, Hao; Ji, Xiaonan

2018-02-26

Central Asia is a region that has a large land mass, yet meteorological stations in this area are relatively scarce. To address this data issues, in this study, we selected two reanalysis datasets (the ERA40 and NCEP/NCAR) and downscaled them to 40 × 40 km using RegCM. Then three gridded datasets (the CRU, APHRO, and WM) that were extrapolated from the observations of Central Asian meteorological stations to evaluate the performance of RegCM and analyze the spatiotemporal distribution of precipitation and air temperature. We found that since the 1960s, the air temperature in Xinjiang shows an increasing trend and the distribution of precipitation in the Tianshan area is quite complex. The precipitation is increasing in the south of the Tianshan Mountains (Southern Xinjiang, SX) and decreasing in the mountainous areas. The CRU and WM data indicate that precipitation in the north of the Tianshan Mountains (Northern Xinjiang, NX) is increasing, while the APHRO data show an opposite trend. The downscaled results from RegCM are generally consistent with the extrapolated gridded datasets in terms of the spatiotemporal patterns. We believe that our results can provide useful information in developing a regional climate model in Central Asia where meteorological stations are scarce.

Topical safety analysis report for the transportation of the NUHOMS{reg_sign} dry shielded canister. Volume 1

Energy Technology Data Exchange (ETDEWEB)

None

1993-08-01

This Topical Safety Analysis Report (SAR) describes the design and the generic transportation licensing basis for utilizing the NUTECH HORIZONTAL MODULAR STORAGE (NUHOMS{reg_sign}) system dry shielded canister (DSC) containing twenty-four pressurized water reactor (PWR) spent fuel assemblies (SFA) in conjunction with a conceptually designed Transportation Cask. This SAR documents the design qualification of the NUHOMS{reg_sign} DSC as an integral part of a 10CFR71 Fissile Material Class III, Type B(M) Transportation Package. The package consists of the canister and a conceptual transportation cask (NUHOMS{reg_sign} Transportation Cask) with impact limiters. Engineering analysis is performed for the canister to confirm that the existing canister design complies with 10CFR71 transportation requirements. Evaluations and/or analyses is performed for criticality safety, shielding, structural, and thermal performance. Detailed engineering analysis for the transportation cask will be submitted in a future SAR requesting 10CFR71 certification of the complete waste package. Transportation operational considerations describe various operational aspects of the canister/transportation cask system. operational sequences are developed for canister transfer from storage to the transportation cask and interfaces with the cask auxiliary equipment for on- and off-site transport.

REG4 Is Highly Expressed in Mucinous Ovarian Cancer: A Potential Novel Serum Biomarker.

Directory of Open Access Journals (Sweden)

Laura Lehtinen

Full Text Available Preoperative diagnostics of ovarian neoplasms rely on ultrasound imaging and the serum biomarkers CA125 and HE4. However, these markers may be elevated in non-neoplastic conditions and may fail to identify most non-serous epithelial cancer subtypes. The objective of this study was to identify histotype-specific serum biomarkers for mucinous ovarian cancer. The candidate genes with mucinous histotype specific expression profile were identified from publicly available gene-expression databases and further in silico data mining was performed utilizing the MediSapiens database. Candidate biomarker validation was done using qRT-PCR, western blotting and immunohistochemical staining of tumor tissue microarrays. The expression level of the candidate gene in serum was compared to the serum CA125 and HE4 levels in a patient cohort of prospectively collected advanced ovarian cancer. Database searches identified REG4 as a potential biomarker with specificity for the mucinous ovarian cancer subtype. The specific expression within epithelial ovarian tumors was further confirmed by mRNA analysis. Immunohistochemical staining of ovarian tumor tissue arrays showed distinctive cytoplasmic expression pattern only in mucinous carcinomas and suggested differential expression between benign and malignant mucinous neoplasms. Finally, an ELISA based serum biomarker assay demonstrated increased expression only in patients with mucinous ovarian cancer. This study identifies REG4 as a potential serum biomarker for histotype-specific detection of mucinous ovarian cancer and suggests serum REG4 measurement as a non-invasive diagnostic tool for postoperative follow-up of patients with mucinous ovarian cancer.

Uma proposta de dicionário de regência verbal português-espanhol para aprendizes brasileiros de espanhol

OpenAIRE

Aline Noimann

2015-01-01

Esta tese apresenta as bases para a elaboração de um protótipo de dicionário de regência verbal para alunos brasileiros estudantes de Espanhol como Língua Estrangeira e se insere na área de Estudos da Linguagem, mais especificamente na linha de pesquisa Lexicografia, Terminologia e Tradução: relações textuais. O objetivo geral desta tese é o de estabelecer os princípios e o protótipo para a elaboração de um dicionário de regência verbal Português-Espanhol para alunos brasileiros estudantes de...

Regional climate projection based on RCP scenarios in the CORDEX East Asia Domain Using RegCM4

Science.gov (United States)

Suh, M. S.; Oh, S. G.; Cha, D. H.; Kang, H. S.

2012-04-01

Regional climate projection data is essential to the adaptation and risk management for the expected climate change. In this stduy, we reproduced regional climate over CORDEX East Asia for 72 years from 1979 to 2050 with 50-km resolution using the latest regional climate model version 4, RegCM4, driven by HadGEM2-AO with about 135-km resolution under Intergovernmental Panel on Climate Change (IPCC) Representative Concentration Pathway (RCP) 8.5/4.5. Simulation skills of RegCM4 for the present climate (1980-2005, spin up time: 1979) over CORDEX East Asia are evaluated with CRU-TS (Climate Research Unit Time-Series) 3.0 and GPCP (Global Precipitation Climatology Project). And KMA ground observation data are also used for the detailed assessment of RegCM4 over South Korea. The evaluation results showed that RegCM4 reasonalbly simulated the spatial distribution, and inter-annual and seasonal variations of surface air temperature. However, it showed a non-negligible systemartic biases in the precipitation. In particular, the rainband accompanied by the seasonal march of East Asian summer monsoon was simulated too southward, below 30° N comparing to the GPCP. As a reulst, summer precipitation over South Korea and Japan island was significantly underestimated. Under RCP8.5 (RCP4.5) scenario, annual mean temperature over the CORDEX East Asia is expected to increase by + 1.6 oC(+1.4oC) above the present level (1980-2005) by the end of the future simulation period. Most of the regions (South-Korea, South-China, North-China, India, Japan, Mongolia) show the increaseing trend of surface air temperature. On the other hand, the future changes of precipitation are not systemaic at the most of regions and seasons. More detailed results including projected regional climate change will be discussed in the presentation.

Comparative Study of a Real-Time PCR Assay Targeting senX3-regX3 versus Other Molecular Strategies Commonly Used in the Diagnosis of Tuberculosis.

Directory of Open Access Journals (Sweden)

Rocio Sanjuan-Jimenez

Full Text Available Nucleic acid amplification tests are increasingly used for the rapid diagnosis of tuberculosis. We undertook a comparative study of the efficiency and diagnostic yield of a real-time PCR senX3-regX3 based assay versus the classical IS6110 target and the new commercial methods.This single-blind prospective comparative study included 145 consecutive samples: 76 from patients with culture-confirmed tuberculosis (86.8% pulmonary and 13.2% extrapulmonary tuberculosis: 48.7% smear-positive and 51.3% smear-negative and 69 control samples (24 from patients diagnosed with non-tuberculous mycobacteria infections and 45 from patients with suspected tuberculosis which was eventually ruled out. All samples were tested by two CE-marked assays (Xpert®MTB/RIF and AnyplexTM plus MTB/NTM and two in-house assays targeting senX3-regX3 and the IS6110 gene.The detection limit ranged from 1.00E+01 fg for Anyplex, senX3-regX3 and IS6110 to 1.00E+04 fg for Xpert. All three Xpert, senX3-regX3 and IS6110 assays detected all 37 smear-positive cases. Conversely, Anyplex was positive in 34 (91.9% smear-positive cases. In patients with smear-negative tuberculosis, differences were observed between the assays; Xpert detected 22 (56.41% of the 39 smear-negative samples, Anyplex 24 (61.53%, senX3-regX3 28 (71.79% and IS6110 35 (89.74%. Xpert and senX3-regX3 were negative in all control samples; however, the false positive rate was 8.7% and 13% for Anyplex and IS6110, respectively. The overall sensitivity was 77.6%, 85.7%, 77.3% and 94.7% and the specificity was 100%, 100%, 90.8% and 87.0% for the Xpert, senX3-regX3, Anyplex and IS6110 assays, respectively.Real-time PCR assays targeting IS6110 lack the desired specificity. The Xpert MTB/RIF and in-house senX3-regX3 assays are both sensitive and specific for the detection of MTBC in both pulmonary and extrapulmonary samples. Therefore, the real time PCR senX3-regX3 based assay could be a useful and complementary tool in the

Remediation of groundwater containing radionuclides and heavy metals using ion exchange and the AlgaSORB reg-sign biosorbent system

International Nuclear Information System (INIS)

Feiler, H.D.; Darnall, D.W.

1991-01-01

Bio-Recovery Systems, Inc. (BRS) studied the application of an immobilized algal biomass, termed AlgaSORB reg-sign, which has high affinity for heavy metal ions to DOE-contaminated groundwaters. The material can be packed into columns similar to commercial ion exchange resins. Dilute solutions containing heavy metals are passed through columns where metals are absorbed by the AlgaSORB reg-sign resins. Once saturated, metal ions can be stripped from the resin biomass in a highly concentrated solution. Groundwaters contaminated with heavy metal ions from three different Department of Energy (DOE) sites: Savannah River, Hanford and the Oak Ridge Y-12 Plant were studied. The objective was to perform bench-scale treatability studies to establish treatment protocols and to optimize an AlgaSORB reg-sign/ion exchange technology system to remove and recover toxic metal ions from these contaminated groundwaters. The specialty ion exchange/AlgaSORB reg-sign resins tested in these studies show promise for selectively removing chromium, mercury and uranium from contaminated groundwater at DOE sites. The data show that effluents which satisfy the allowable metal ion limits are possible and most likely achievable. The use of these highly selective resins also offer advantages in terms of cost/benefit, risk and scheduling. Their high selectivity allows for high capacity and opportunities for recovery of removed constituents due to high pollutant concentration possible (3 to 4 orders of magnitude). Ion exchange is a proven technology which is easily automated and can be cost-effective, depending on the application

Design ampersand operational experience of the NUHOMS reg-sign-24P spent fuel storage system

International Nuclear Information System (INIS)

McConaghy, W.J.; Lehnert, R.A.; Rasmussen, R.W.

1991-01-01

The NUHOMS reg-sign Spent Fuel Storage System provides a safe and economical method for the dry storage of spent fuel assemblies either at an at-reactor Independent Spent Fuel Storage Installation (ISFSI) or at a centralized away-from-reactor (AFR) storage facility. The system consists of three major safety related components: a dry shielded canister (DSC) which provides a high integrity containment boundary and a controlled storage environment for the fuel; a reinforced concrete horizontal storage module (HSM) which houses the stored DSC and provides radiation shielding, protection against natural phenomena, and an efficient means for decay heat removal; and a transfer cask which provides for the safe shielded transfer of the DSC from the plant spent fuel pool to the HSM. The NUHOMS reg-sign system is designed and licensed to the requirements of 10 CFR 72 and ANS/ANSI 57.9 for ISFSIs

Expression of Gast, Cckbr, Reg1α genes in rat duodenal epithelial cells upon long-term gastric hypoacidity and after a multiprobiotic administration

Directory of Open Access Journals (Sweden)

Dranitsina A. S.

2014-11-01

Full Text Available Aim. Determination of the Cckbr, Gast and Reg1α genes expression in rat duodenal epithelial cells upon long- term hypoacidity and with the administration of the multiprobiotic Symbiter. Methods. The experiments were carried out on white non-strain male rats. The hypoacidic state was induced through intraperitoneal injection of omeprazole for 28 days. The level of genes expression was determined by semi-quantitative analysis with RT-PCR Results. The elevation of mRNA levels of the Cckbr and Gast genes in rat duodenal villus and crypt epitheliocytes, the increased expression of the Reg1A gene in crypt epithelial cells were shown as well as the appearance of the Reg1a gene expression in villus epitheliocytes upon hypoacidic conditions were shown. The content of mRNAs of the above mentioned genes decreased or remained at the control level upon the treatment of hypoacidic rats with the multiprobiotic Symbiter. Conclusions. Long-term gastric hypoacidity is accompanied by the changes in expression of the Cckbr, Gast and Reg1a genes in rat duodenum, whereas upon administration of the multiprobiotic Symbiter the pattern of studied gene expression did not changed in the most cases.

DC-transport properties of QMG(reg sign) current-limiting elements; QMG(reg sign) genryusoshi no chokuryutuden tokusei

Energy Technology Data Exchange (ETDEWEB)

Morita, M.; Tokunaga, Y. [Nippon Steel Corporation, Tokyo (Japan); Miura, D.; Ito, D. [Tokyo Metroporitan University, Tokyo (Japan)

1999-11-25

The V-I properties of YBCO bulk superconductor (QMG(reg sign) :YBa{sub 2}Cu{sub 3}O{sub 7-x} single-crystal containing Y{sub 2}BaCuO{sub 5} particles) were measured using a single rectangular pule current at 77 and 87 K to obtain basic data for super-normal transition. Because of its high J{sub c} property, QMG is a promising bulk material for resistive-type HTC-FCL application. I-shaped QMG rods having cross sections of 0.5 x 1.0 mm were prepared to measure voltage due to pule current. The plots of ln V vs ln I yielded a straight line with a gradient ranging from 5 to 7. By changing the amplitude and length of pulses, the time from the start of sending electricity till the occurrence of quenching was obtained for various amplitudes of pulse current. In this experiment, it is considered that quenching did not occur in the whole rod but only in a small part of it. (author)

Clinical experience with the MammoSite[reg] radiation therapy system for brachytherapy of breast cancer: Results from an international phase II trial

International Nuclear Information System (INIS)

Niehoff, Peter; Polgar, Csaba; Ostertag, Horst; Major, Tibor; Sulyok, Zoltan; Kimmig, Bernhard; Kovacs, Gyoergy

2006-01-01

Background and purpose: In a prospective multi-center phase II trial, we investigated the MammoSite[reg] Radiation Therapy System, a new device for delivering intracavitary brachytherapy following breast conserving surgery. The MammoSite[reg] is a dual lumen, closed ended catheter with a small, spherical inflatable balloon and a port for connecting a remote afterloader to the central lumen. We analyzed the surgical procedure and placement of the MammoSite[reg], treatment planning and radiation delivery complications and cosmesis, as well the comfort for the patients. Patients and methods: Between 2002 and 2004 a total of 32 patients (pts) were implanted using the MammoSite[reg]. The reference isodose was defined 1 cm from the balloon surface. We analyzed the post-implant anatomic position of the applicator and the geometric form of the balloon via ultrasound, CT and X-ray, related side effects, cosmetic outcome and patient quality of life. Results: Twenty-three out of 32 patients (72%) were eligible for MammoSite[reg] intracavitary brachytherapy. Twenty-eight percentage had to be excluded because of different reasons. Eleven patients were treated with primary brachytherapy with a total dose of 34 Gy (2x3.4 Gy) and 12 had a boost with a mean dose of 13.3 Gy (range: 7.5-15 Gy; 2x2.5 Gy) combined with EBRT and doses ranged between 46 and 50 Gy. In three cases a balloon rupture occurred. We observed two abscesses within 3 months of implantation and serious seroma development in 10 patients (39%). Skin related side effects were erythema in 21 patients (91%), hyperpigmentation in 13 patients (56%) and teleangiectasia in six patients (26%) after mean follow-up 20 months. Conclusions: The MammoSite[reg] Radiation Therapy System is a feasible treatment modality for intracavitary brachytherapy of breast cancer after breast conserving surgery. The advantage of the system is only one applicator is necessary for the delivery of a fractionated radiotherapy. In addition, patient

BagReg: Protein inference through machine learning.

Science.gov (United States)

Zhao, Can; Liu, Dao; Teng, Ben; He, Zengyou

2015-08-01

Protein inference from the identified peptides is of primary importance in the shotgun proteomics. The target of protein inference is to identify whether each candidate protein is truly present in the sample. To date, many computational methods have been proposed to solve this problem. However, there is still no method that can fully utilize the information hidden in the input data. In this article, we propose a learning-based method named BagReg for protein inference. The method firstly artificially extracts five features from the input data, and then chooses each feature as the class feature to separately build models to predict the presence probabilities of proteins. Finally, the weak results from five prediction models are aggregated to obtain the final result. We test our method on six public available data sets. The experimental results show that our method is superior to the state-of-the-art protein inference algorithms. Copyright © 2015 Elsevier Ltd. All rights reserved.

A Saccharomyces cerevisiae mitochondrial DNA fragment activates Reg1p-dependent glucose-repressible transcription in the nucleus.

Science.gov (United States)

Santangelo, G M; Tornow, J

1997-12-01

As part of an effort to identify random carbon-source-regulated promoters in the Saccharomyces cerevisiae genome, we discovered that a mitochondrial DNA fragment is capable of directing glucose-repressible expression of a reporter gene. This fragment (CR24) originated from the mitochondrial genome adjacent to a transcription initiation site. Mutational analyses identified a GC cluster within the fragment that is required for transcriptional induction. Repression of nuclear CR24-driven transcription required Reg1p, indicating that this mitochondrially derived promoter is a member of a large group of glucose-repressible nuclear promoters that are similarly regulated by Reg1p. In vivo and in vitro binding assays indicated the presence of factors, located within the nucleus and the mitochondria, that bind to the GC cluster. One or more of these factors may provide a regulatory link between the nucleus and mitochondria.

Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG protein in fulminant type 1 diabetes.

Directory of Open Access Journals (Sweden)

Kaoru Aida

Full Text Available BACKGROUND: Pancreatic islet endocrine cell-supporting architectures, including islet encapsulating basement membranes (BMs, extracellular matrix (ECM, and possible cell clusters, are unclear. PROCEDURES: The architectures around islet cell clusters, including BMs, ECM, and pancreatic acinar-like cell clusters, were studied in the non-diabetic state and in the inflamed milieu of fulminant type 1 diabetes in humans. RESULT: Immunohistochemical and electron microscopy analyses demonstrated that human islet cell clusters and acinar-like cell clusters adhere directly to each other with desmosomal structures and coated-pit-like structures between the two cell clusters. The two cell-clusters are encapsulated by a continuous capsule composed of common BMs/ECM. The acinar-like cell clusters have vesicles containing regenerating (REG Iα protein. The vesicles containing REG Iα protein are directly secreted to islet cells. In the inflamed milieu of fulminant type 1 diabetes, the acinar-like cell clusters over-expressed REG Iα protein. Islet endocrine cells, including beta-cells and non-beta cells, which were packed with the acinar-like cell clusters, show self-replication with a markedly increased number of Ki67-positive cells. CONCLUSION: The acinar-like cell clusters touching islet endocrine cells are distinct, because the cell clusters are packed with pancreatic islet clusters and surrounded by common BMs/ECM. Furthermore, the acinar-like cell clusters express REG Iα protein and secrete directly to neighboring islet endocrine cells in the non-diabetic state, and the cell clusters over-express REG Iα in the inflamed milieu of fulminant type 1 diabetes with marked self-replication of islet cells.

Effects of reducing blood pressure on renal outcomes in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.

Science.gov (United States)

Scheen, A J; Delanaye, P

2017-04-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has enabled remarkable reductions in cardiovascular and all-cause mortality as well as in renal outcomes in patients with type 2 diabetes (T2D) and a history of cardiovascular disease in the EMPA-REG OUTCOME. These results have been attributed to haemodynamic rather than metabolic effects, in part due to the osmotic/diuretic action of empagliflozin and the reduction in arterial blood pressure (BP). The present narrative review includes the results of meta-analyses of trials evaluating the effects on renal outcomes of lowering BP in patients with T2D, with a special focus on the influence of baseline and achieved systolic BP, and compares the renal outcome results of the EMPA-REG OUTCOME with those of other major trials with inhibitors of the renin-angiotensin system in patients with T2D and the preliminary findings with other SGLT2 inhibitors, and also evaluates post hoc analyses from the EMPA-REG OUTCOME of special interest as regards the BP-lowering hypothesis and renal function. While systemic BP reduction associated to empagliflozin therapy may have contributed to the renal benefits reported in EMPA-REG OUTCOME, other local mechanisms related to kidney homoeostasis most probably also played a role in the overall protection observed in the trial. Copyright © 2017. Published by Elsevier Masson SAS.

NordREG report on the price peaks in the Nordic wholesale market during winter 2009-2010. Final report

Energy Technology Data Exchange (ETDEWEB)

2011-01-15

In winter 2009-2010, prices peaked on three days. The high prices that were experienced in the majority of the Nord Pool Spot price areas initiated a study on the reasons that led to the price spikes and on the possible measures to develop the Nordic market arrangements to avoid such situations in the future. The analysis of the winter 2009-2010 events revealed that there were a number of primary causes for the occurrence of the price peaks and no single individual cause could be pinpointed to bear the key responsibility. The fact that the weather was cold all over the Nordic area in conjunction with the low availability for the Swedish nuclear generation capacity, however, could be indicated as the key underlying causes. The analysis also showed that the way the Nordic transmission capacity is allocated can be listed as an additional factor complementing to the occurrence of the price peaks. Thus, NordREG concluded that a review of the methods of calculating and allocating transmission capacity for the market should be carried out. As a part of this, an analysis that addresses the delimitation of bidding areas and maintenance planning of the transmission network infrastructure should be prepared as well. The flexibility on the demand side has not been very large in the Nordic region. However, the background study prepared by Gaia Consulting showed that even small degree of increased price elasticity could substantially cut the price peaks. This could be seen as an improvement potential of the trading system reflecting the present inability of the market participants to react on the price signals the market place provides. Therefore, NordREG sees that facilitating the appearance of a real price elastic behaviour of the users of electricity can be regarded as one of the key fixes for the problem. Furthermore, NordREG proposes that a consultancy study on how to promote demand flexibility in the Nordic market in a coherent way should be prepared. A further area for

Projecte d’una instal•lació solar fotovoltaica per a un sistema de bombes de reg

OpenAIRE

Batllori Alvarez, Eduard

2009-01-01

Instal.lació d’una explotació agrícola amb funcionament per energia solar fotovoltaica a Torregrossa (Tarragona). Disseny i definició de les parts necessàries que conformaran la instal•lació solar fotovoltaica que subministrarà energia elèctrica a les bombes de reg

Projecte d’una instal•lació solar fotovoltaica per a un sistema de bombes de reg

OpenAIRE

Batllori Alvarez, Eduard

2010-01-01

Instal.lació d’una explotació agrícola amb funcionament per energia solar fotovoltaica a Torregrossa (Tarragona). Disseny i definició de les parts necessàries que conformaran la instal•lació solar fotovoltaica que subministrarà energia elèctrica a les bombes de reg

Evaluation of Boulder, CO, SmartRegs Ordinance and Better Buildings Program

Energy Technology Data Exchange (ETDEWEB)

Arena, L.; Vijayakumar, G.

2012-04-01

Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE's Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

Evaluation of Boulder, CO,SmartRegs Ordinance and Better Buildings Program

Energy Technology Data Exchange (ETDEWEB)

Arena, L. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States); Vijayakumar, G. [Consortium for Advanced Residential Buildings (CARB), Norwalk, CT (United States)

2012-04-01

Under the SmartRegs ordinance in the city of Boulder, Colorado, all rental properties in the city must achieve an energy efficiency level comparable to a HERS Index of approximately 120 points or lower by the year 2019. The City of Boulder received a $12 million grant from the DOE’s Better Buildings initiative to create and incentivize their EnergySmart Program. In this report, the Consortium for Advanced Residential Buildings (CARB) describes its work with the program, including energy audits of rental properties, developing training programs for insulators and inspectors, and conducting interviews with property owners.

Best convective parameterization scheme within RegCM4 to downscale CMIP5 multi-model data for the CORDEX-MENA/Arab domain

Science.gov (United States)

Almazroui, Mansour; Islam, Md. Nazrul; Al-Khalaf, A. K.; Saeed, Fahad

2016-05-01

A suitable convective parameterization scheme within Regional Climate Model version 4.3.4 (RegCM4) developed by the Abdus Salam International Centre for Theoretical Physics, Trieste, Italy, is investigated through 12 sensitivity runs for the period 2000-2010. RegCM4 is driven with European Centre for Medium-Range Weather Forecasts (ECMWF) ERA-Interim 6-hourly boundary condition fields for the CORDEX-MENA/Arab domain. Besides ERA-Interim lateral boundary conditions data, the Climatic Research Unit (CRU) data is also used to assess the performance of RegCM4. Different statistical measures are taken into consideration in assessing model performance for 11 sub-domains throughout the analysis domain, out of which 7 (4) sub-domains give drier (wetter) conditions for the area of interest. There is no common best option for the simulation of both rainfall and temperature (with lowest bias); however, one option each for temperature and rainfall has been found to be superior among the 12 options investigated in this study. These best options for the two variables vary from region to region as well. Overall, RegCM4 simulates large pressure and water vapor values along with lower wind speeds compared to the driving fields, which are the key sources of bias in simulating rainfall and temperature. Based on the climatic characteristics of most of the Arab countries located within the study domain, the drier sub-domains are given priority in the selection of a suitable convective scheme, albeit with a compromise for both rainfall and temperature simulations. The most suitable option Grell over Land and Emanuel over Ocean in wet (GLEO wet) delivers a rainfall wet bias of 2.96 % and a temperature cold bias of 0.26 °C, compared to CRU data. An ensemble derived from all 12 runs provides unsatisfactory results for rainfall (28.92 %) and temperature (-0.54 °C) bias in the drier region because some options highly overestimate rainfall (reaching up to 200 %) and underestimate

Comparative effects of split Orimulsion reg-sign, fuel oil number-sign 6 and Lago Medio Crude oil over functional variables of an estuarine community

International Nuclear Information System (INIS)

Quilici, A.; Rodriguez-Grau, J.; Vasquez, P.; Infante, C.; Schiazza, J. La; Briceno, H.; Pereira, N.

1995-01-01

This study evaluates the effects, on comparative bases, of three different kinds of hydrocarbon products, on physiological and dynamic parameters of a mangrove community (located East of Venezuela), by experimentally monitoring changes on those parameters using Laguncularia racemosa as a bioindicator mangrove species. Orimulsion reg-sign has been introduced recently in the World market; and it is, in essence, an emulsion produced from bitumen mixed with water and stabilized with a surfactant. Results indicate that litter disappearance rate, a parameter directly related to nutrient cycling and dynamics, is not altered by the split Orimulsion reg-sign, when compared to controls; while the other hydrocarbon products tested, seem to exert an impact over this parameter. In addition, Orimulsion reg-sign, is less retained in mangrove sediments compared with the other two products, as indicated by the remaining percent mean of total hydrocarbon soil content sampled on the same consecutive dates. Nonetheless, the photosynthetic capacity of leaves as well as soil respiratory rates, monitored at treatment and control plots, were not affected by any of the products tested. In conclusion, L. racemosa, in terms of its photosynthetic capacity, is not directly affected by any of the hydrocarbon products tested, nor does there seem to be an effect on soil respiration; however, Orimulsion reg-sign, in contrast to the other products, does not seem to be causing an impact with regard to litter dynamics

The use of dilute calogen[reg] as a fat density oral contrast medium in upper abdominal computed tomography, compared with the use of water and positive oral contrast media

International Nuclear Information System (INIS)

Ramsay, Duncan W.; Markham, Derrian H.; Morgan, Bruno; Rodgers, Peter M.; Liddicoat, Amanda J.

2001-01-01

AIM: Oral contrast media are commonly given prior to computed tomography (CT) examination of the upper abdomen. Although positive oral contrast media are normally used, there is increasing interest in using negative agents such as water and less commonly fat density products. The aim of this study was to compare a positive oral contrast medium, water, and a diluted emulsion of arachis oil (Calogen[reg], a fat density food supplement) for assessment of the upper abdomen. MATERIALS AND METHODS: Seventy-one patients referred for upper abdominal CT were randomized to receive either 500 ml water, 2% sodium diatrizoate or a dilute suspension of Calogen[reg]. The CT images were scored independently by three radiologists. Distension and anatomical identification was assessed for the stomach, duodenum and jejunum; with anatomical identification recorded for the pancreas, retroperitoneum, liver, gallbladder and spleen. RESULTS: Dilute Calogen[reg] produced a significant improvement (P < 0.01) in distension and anatomical visualization of the stomach and proximal duodenum. Only minimal differences were demonstrated between the three contrast media for visualization of more distal small bowel or identification of the other upper abdominal viscera. Significantly more artifacts were caused by positive contrast media than with the Calogen[reg] mixture. CONCLUSION: A dilute suspension of Calogen[reg] as an oral contrast medium is recommended when disease is suspected within the stomach or proximal duodenum. Ramsay, D.W. et al. (2001)

Reappraisal of the diuretic effect of empagliflozin in the EMPA-REG OUTCOME trial: Comparison with classic diuretics.

Science.gov (United States)

Scheen, A J

2016-09-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has been associated with a remarkable reduction in cardiovascular and all-cause mortality in patients with type 2 diabetes and antecedents of cardiovascular disease. This effect was attributed to a diuretic (haemodynamic) rather than metabolic (antiatherogenic) effect. The aim of this review is to offer arguments that either support or challenge this 'diuretic hypothesis'. The literature was scrutinized to: (1) examine the diuretic effects of SGLT2 inhibitors vs. hydrochlorothiazide as the reference diuretic; (2) analyze the effects of classic diuretics on cardiovascular outcomes and mortality in diabetic patients; and (3) reconsider some of the specific analyses of the EMPA-REG OUTCOME trial possibly related to a diuretic effect. The diuretic effect of empagliflozin has so far been poorly investigated, although SGLT2 inhibitors have actions distinct from those of classic diuretics. The effects of thiazide-like diuretics on cardiovascular and overall mortality have been limited in diabetic patients with hypertension, whereas the effects of mineralocorticoid receptor antagonists in subgroups of diabetic patients with heart failure were more impressive, but still largely inferior to those reported in EMPA-REG, where relative reductions in mortality with empagliflozin were observed in diabetic patients with or without heart failure, arterial hypertension, renal impairment or diuretic background therapy. Although the diuretic hypothesis was put forward to explain the remarkable reduction in mortality with empagliflozin in EMPA-REG, the available results do not support a major contribution of this mechanism, unless the specific diuretic effect of SGLT2 inhibitors turns out to be markedly different from those of classic diuretics. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

Effects of reducing blood pressure on cardiovascular outcomes and mortality in patients with type 2 diabetes: Focus on SGLT2 inhibitors and EMPA-REG OUTCOME.

Science.gov (United States)

Scheen, André J

2016-11-01

Empagliflozin, a sodium-glucose cotransporter type 2 (SGLT2) inhibitor, has shown a remarkable reduction in cardiovascular and all-cause mortality in patients with type 2 diabetes (T2D) and antecedents of cardiovascular disease in the EMPA-REG OUTCOME trial. This effect has been attributed to a hemodynamic rather than a metabolic effect, partly due to the osmotic/diuretic effect of empagliflozin and to the reduction in arterial blood pressure. The present review will: (1) summarize the results of specific studies having tested the blood pressure lowering effects of SGLT2 inhibitors; (2) describe the results of meta-analyses of trials having evaluated the effects on mortality and cardiovascular outcomes of lowering blood pressure in patients with T2D, with a special focus on baseline and target blood pressures; (3) compare the cardiovascular outcome results in EMPA-REG OUTCOME versus other major trials with antihypertensive agents in patients with T2D; and (4) evaluate post-hoc analyses from EMPA-REG OUTCOME, especially subgroups of patients of special interest regarding the blood pressure lowering hypothesis. Although BP reduction associated to empagliflozin therapy may partly contribute to the benefits reported in EMPA-REG OUTCOME, other mechanisms most probably play a greater role in the overall CV protection and reduction in mortality observed in this trial. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

Closing the knowledge gap on cardiovascular disease in type 2 diabetes: the EMPA-REG OUTCOME trial and beyond

Directory of Open Access Journals (Sweden)

Elif A Oral

2016-09-01

Full Text Available Type 2 diabetes mellitus (T2DM is associated with marked cardiovascular (CV morbidity and mortality, including heartfailure (HF. Until recently, an oral glucose-lowering agent that improved hyperglycemia as well as provided CV benefits in patients with T2DM and cardiovascular disease (CVD was lacking. The newest class of glucose-lowering agents, sodium glucose cotransporter 2 (SGLT2 inhibitors, includes canagliflozin, dapagliflozin, and empagliflozin. Prior to the release of the LEADER trial results, the recent EMPA-REG OUTCOME study was the only dedicated CV trial to demonstrate a reduction in major adverse cardiac events, CV mortality, and all-cause mortality and a reduction in hospitalization for HF with empagliflozin, given on top of standard-of-care therapy in patients with T2DM and CVD. This paper summarizes the results from EMPA-REG OUTCOME and discusses their significance and clinical implications.

Innovative remote monitoring of plant health for environmental applications: A joint effort between EPCOT{reg_sign} and the DOE

Energy Technology Data Exchange (ETDEWEB)

Robitaille, H. [Walt Disney World Resort, Lake Buena Vista, FL (United States); Capelle, G.; Di Benedetto, J. [Special Technologies Lab., Santa Barbara, CA (United States)] [and others

1996-12-31

In September of 1994, the US Department of Energy (DOE), Environmental Management, Office of Science and Technology for (OST) and Epcot{reg_sign} in the WALT DISNEY WORLD{reg_sign} Resort (Epcot) signed an agreement to cooperate on the research, development, and public communication and display of environmental technologies. Although Epcot and OST have distinctive missions, certain areas of their respective research and development efforts are common, including the integration of remote sensors with robotics platforms, airborne surveys for environmental characterization and monitoring, and ground based measurements of vegetation stress. The first area of cooperative R&D pursued under the agreement is the evaluation of laser-induced fluorescence imaging (LIFI), a technology developed by OST and proven effective for uranium detection. This paper describes the efforts being conducted under the Epcot-OST agreement and presents initial results. An appendix describing LIFI technology is also included.

Image registration of BANG[reg] gel dose maps for quantitative dosimetry verification

International Nuclear Information System (INIS)

Meeks, Sanford L.; Bova, Frank J.; Maryanski, Marek J.; Kendrick, Lance A.; Ranade, Manisha K.; Buatti, John M.; Friedman, William A.

1999-01-01

Background: The BANG[reg] (product symbol SGEL, MGS Research Inc., Guilford, CT) polymer gel has been shown to be a valuable dosimeter for determining three-dimensional (3D) dose distributions. Because the proton relaxation rate (R2) of the gel changes as a function of absorbed dose, MR scans of the irradiated gel can be used to generate 3D dose maps. Previous work with the gel, however, has not relied on precise localization of the measured dose distribution. This has limited its quantitative use, as no precise correlation exists with the planned distribution. This paper reports on a technique for providing this correlation, thus providing a quality assurance tool that includes all of the steps of imaging, treatment planning, dose calculation, and treatment localization. Methods and Materials: The BANG[reg] gel formulation was prepared and poured into spherical flasks (15.3-cm inner diameter). A stereotactic head ring was attached to each flask. Three magnetic resonance imaging (MRI) and computed tomography (CT) compatible fiducial markers were placed on the flask, thus defining the central axial plane. A high-resolution CT scan was obtained of each flask. These images were transferred to a radiosurgery treatment-planning program, where treatment plans were developed. The gels were irradiated using our systems for stereotactic radiosurgery or fractionated stereotactic radiotherapy. The gels were MR imaged, and a relative 3D dose map was created from an R2 map of these images. The dose maps were transferred to an image-correlation program, and then fused to the treatment-planning CT scan through a rigid body match of the MRI/CT-compatible fiducial markers. The fused dose maps were imported into the treatment-planning system for quantitative comparison with the calculated treatment plans. Results: Calculated and measured isodose surfaces agreed to within 2 mm at the worst points within the in-plane dose distributions. This agreement is excellent, considering that

Road map towards a common harmonised Nordic end-user market. NordREG report 5 - 2013

Energy Technology Data Exchange (ETDEWEB)

NONE

2013-07-01

The purpose of this road map is to describe the overall process to harmonise the Nordic electricity end-user markets. The main target groups for the road map are the Nordic governments, legislators and the electricity industry. The road map will continuously be updated as the project progresses, at least once a year. It describes the recommendations already made by NordREG, as well as indicates up-coming recommendations. One important part of the Nordic harmonisation process is the monitoring of the progress of the project. It will be communicated through national implementation monitoring overviews, which will describe the state of play for each recommendation made by NordREG. The road map highlights the importance of national commitment by different stakeholders, authorities and governments in order to successfully harmonise the Nordic end-user markets. This commitment is absolutely essential. The goal for 2015 is to harmonise some of the legislation, rules and processes that constitute barriers for suppliers to establish their business in other Nordic countries. In order to achieve this goal, NordREG is working towards defining responsibilities in the customer interface of the supplier centric model and the way of billing the customers. Another important task is related to development of an efficient way of communication among a large number of Nordic electricity companies. By 2015 the end-user markets should be harmonised to the extent that the most critical prerequisites have been achieved. But it is important to bear in mind that there are still many more steps to be taken also after 2015. The harmonisation process between the Nordic retail markets is a process that will continue for the foreseeable future. Since there is no supranational organisation or institution (like in the EU), it means that any future development of the Nordic retail market will have to be continuously coordinated between the Nordic countries to ensure that the markets maintain the

A prospective randomised controlled trial to determine the early and late reactions after the use of iopamidol 340 (NiopamTM) and iomeprol 350 (Iomeron[reg]) in cardiac catheterisation

International Nuclear Information System (INIS)

Vijayalakshmi, Kunadian; Kunadian, Babu; Wright, Robert A.; Hall, James A.; Stewart, Michael J.; Davies, Adrian; Sutton, Andrew; Belder, Mark A. de

2007-01-01

A new generation of intravascular contrast agents, the non-ionic monomers have safety profiles that are superior to those of older ionic compounds. There are, however, significant differences between these agents. Aim: The aim of this study was to determine the incidence of early ( 24 h to 7 days) reactions to two non-ionic contrast agents currently used during cardiac catheterisation: iopamidol 340 (Niopam TM Bracco UK Ltd.) and iomeprol 350 (Iomeron[reg] Bracco UK Ltd.). Methods: This was a prospective, randomised, double blinded trial. One thousand nine hundred and eighty-five patients undergoing cardiac catheterisation received one of the following contrast agents on a weekly basis: iopamidol 340 (Niopam TM ) and iomeprol 350 (Iomeron[reg]). Reactions that were possibly related to the contrast agents were recorded on predefined data collection forms during the first 24 h of the procedure (early reaction) and after 24 h to 7 days (late reaction) by means of a questionnaire. Results: The baseline characteristics were matched in both the groups. There was no significant difference in the incidence of heat sensation experienced between the two groups (p = 0.1). Early non-heat reactions occurred in 2.7% of patients receiving iopamidol 340 (Niopam TM ) and 4% of those receiving iomeprol 350 (Iomeron[reg]) (p = 0.1). Significant electrocardiographic changes were recorded in 1.7% of patients who received iopamidol 340 (Niopam TM ), and 1% of those who received iomeprol 350 (Iomeron[reg]) (p = 0.2). Bradycardia occurred more frequently in the iopamidol 350 group (0.8%) compared to the iomeprol 350 group (0.1%) p = 0.02. Late reactions occurred in 16.2% of those receiving iopamidol 340 (Niopam TM ) and 21.7% of those receiving iomeprol 350 (Iomeron[reg] (p = 0.02). A total of 23 (3.7%) patients in the iopamidol group and 39 (6.2%) patients in the iomeprol group reported nausea, p = 0.01. Conclusions: The incidence of early adverse reactions was similar with the two non

Simulation of Optical Properties and Direct and Indirect Radiative Effects of Smoke Aerosols Over Marine Stratocumulus Clouds During Summer 2008 in California With the Regional Climate Model RegCM

Science.gov (United States)

Mallet, M.; Solmon, F.; Roblou, L.; Peers, F.; Turquety, S.; Waquet, F.; Jethva, H.; Torres, O.

2017-10-01

The regional climate model RegCM has been modified to better account for the climatic effects of biomass-burning particles. Smoke aerosols are represented by new tracers with consistent radiative and hygroscopic properties to simulate the direct radiative forcing (DRF), and a new parameterization has been integrated for relating the droplet number concentration to the aerosol concentration for marine stratocumulus clouds (Sc). RegCM has been tested during the summer of 2008 over California, when extreme concentration of smoke, together with the presence of Sc, is observed. This work indicates that significant aerosol optical depth (AOD) ( 1-2 at 550 nm) is related to the intense 2008 fires. Compared to Ozone Monitoring Instrument (OMI) and Moderate Resolution Imaging Spectroradiometer, the regional pattern of RegCM AOD is well represented although the magnitude is lower than satellite observations. Comparisons with Polarization and Directionality of Earth Reflectances (POLDER) above-clouds aerosol optical depth (ACAOD) show the ability of RegCM to simulate realistic ACAOD during the transport of smoke above the Pacific Ocean. The simulated single scattering albedo is 0.90 (at 550 nm) near biomass-burning sources, consistent with OMI and POLDER, and smoke leads to shortwave heating rates 1.5-2°K d-1. RegCM is not able to correctly resolve the daily patterns in cloud properties notably due to its coarse horizontal resolutions. However, the changes in the sign of the DRF at top of atmosphere (TOA) (negative to positive) from clear-sky to all-sky conditions is well simulated. Finally, the "aerosol-cloud" parameterization allows simulating an increase of the cloud optical depth for significant concentrations, leading to large perturbations of radiative fluxes at TOA.

Modelo climático de los páramos de la Cordillera Oriental colombiana aplicado a regímenes de temperatura del suelo

Directory of Open Access Journals (Sweden)

Carlos Enrique Castro Méndez

2016-06-01

Full Text Available La aplicación (con criterios consistentes de los regímenes de temperatura del suelo, no había sido necesaria y decisiva, hasta ahora, ya que se consideraba suficiente esta información de carácter descriptivo. La temperatura asignada al suelo provenía de la reclasificación directa del clima ambiental al edáfico con valores medios anuales dados a cada franja altitudinal hace más de 200 años, esto no es acorde con los cambios, que desde la geografía biofísica, se han percibido en el ambiente. Se propone un modelo climático, basado en isotermas del suelo, para determinar los regímenes de temperatura a partir de información bajo coberturas vegetales y del suelo, para cada vertiente montañosa en particular. Se encontraron gradientes de temperatura (ºC/100 m de 0,73 y 0,61 en la vertiente occidental y oriental, respectivamente. La temperatura del suelo fue 1.9 ºC mayor que la del aire y se delimitaron los regímenes térmicos del suelo cryico, isofrígido e isomésico.

Influence of glyphosate and its formulation (Roundup[reg]) on the toxicity and bioavailability of metals to Ceriodaphnia dubia

Energy Technology Data Exchange (ETDEWEB)

Tsui, Martin T.K. [Department of Biology, Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China); Department of Biology, Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong (China); Wang Wenxiong [Department of Biology, The Hong Kong University of Science and Technology (HKUST), Clear Water Bay, Kowloon, Hong Kong (China); Chu, L.M. [Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong (China)]. E-mail: leemanchu@cuhk.edu.hk

2005-11-15

This study examined the toxicological interaction between glyphosate (or its formulation, Roundup[reg]) and several heavy metals to a freshwater cladoceran, Ceriodaphnia dubia. We demonstrated that all binary combinations of Roundup[reg] and metals (Cd, Cu, Cr, Ni, Pb, Se and Zn) exhibited 'less than additive' mixture toxicity, with 48-h LC50 toxic unit>1. Addition of glyphosate alone could significantly reduce the acute toxicity of Ag, Cd, Cr, Cu, Ni, Pb and Zn (but not Hg and Se). The ratio between glyphosate and metal ions was important in determining the mitigation of metal toxicity by glyphosate. A bioaccumulation study showed that in the presence of glyphosate the uptake of some metals (e.g. Ag) was halted but that of others (e.g. Hg) was increased significantly. Therefore, our study strongly suggests that glyphosate and its commercial formulations can control the toxicity as well as the bioavailability of heavy metals in aquatic ecosystems where both groups of chemicals can co-occur. - Glyphosate can control the toxicity and bioavailability of many heavy metals in the aquatic environment.

Influence of glyphosate and its formulation (Roundup[reg]) on the toxicity and bioavailability of metals to Ceriodaphnia dubia

International Nuclear Information System (INIS)

Tsui, Martin T.K.; Wang Wenxiong; Chu, L.M.

2005-01-01

This study examined the toxicological interaction between glyphosate (or its formulation, Roundup[reg]) and several heavy metals to a freshwater cladoceran, Ceriodaphnia dubia. We demonstrated that all binary combinations of Roundup[reg] and metals (Cd, Cu, Cr, Ni, Pb, Se and Zn) exhibited 'less than additive' mixture toxicity, with 48-h LC50 toxic unit>1. Addition of glyphosate alone could significantly reduce the acute toxicity of Ag, Cd, Cr, Cu, Ni, Pb and Zn (but not Hg and Se). The ratio between glyphosate and metal ions was important in determining the mitigation of metal toxicity by glyphosate. A bioaccumulation study showed that in the presence of glyphosate the uptake of some metals (e.g. Ag) was halted but that of others (e.g. Hg) was increased significantly. Therefore, our study strongly suggests that glyphosate and its commercial formulations can control the toxicity as well as the bioavailability of heavy metals in aquatic ecosystems where both groups of chemicals can co-occur. - Glyphosate can control the toxicity and bioavailability of many heavy metals in the aquatic environment

Dicionário multilíngue de regência verbal: equivalentes em francês

OpenAIRE

Sao, Mayara Stringhetta [UNESP

2009-01-01

Este trabalho vincula-se a uma pesquisa maior que está sendo desenvolvida simultaneamente por pesquisadores do GP “Lexicologia e Lexicografia contrastiva”. Tratamos da elaboração de uma obra de referência multilíngüe especial e inédita: o Dicionário Multilíngüe de Regência Verbal: verbos preposicionados, na direção português-alemão / espanhol / francês / inglês / italiano / japonês. Com base no levantamento já realizado dos verbos transitivos indiretos ou transitivos diretos e indiretos mais ...

The establishment and utility of Sweha-Reg: a Swedish population-based registry to understand hereditary angioedema

Directory of Open Access Journals (Sweden)

Werner Sonja

2007-11-01

Full Text Available Abstract Background The importance of acquiring comprehensive epidemiological and clinical data on hereditary angioedema has increasingly caught the attention of physicians and scientists around the world. The development of networks and creation of comprehensive policies to improve care of people suffering from rare diseases, such as hereditary angioedema, is a stated top priority of the European Union. Hereditary angioedema is a rare disease, that it may be life-threatening. Although the exact prevalence is unknown, current estimates suggest that it is 1/10,000–1/150,000 individuals. The low prevalence requires combined efforts to gain accurate epidemiological data on the disease and so give us tools to reduce morbidity and mortality, and improve quality of life of sufferers. Methods Sweha-Reg is a population-based registry of hereditary angioedema in Sweden with the objectives of providing epidemiological data, and so creates a framework for the study of this disease. The registry contains individual-based data on diagnoses, treatments and outcomes. Conclusion The present manuscript seeks to raise awareness of the existence of Sweha-Reg to stimulate the international collaboration of registries. A synthesis of data from similar registries across several countries is required to approach an inclusive course understanding of HAE.

Spatial performance of RegEM climate field reconstruction techniques in a realistic pseudoproxy context

Science.gov (United States)

Wang, J.; Emile-Geay, J.; Guillot, D.

2011-12-01

Several methods of climate field reconstructions (CFRs) have been introduced in the past few years to estimate past climate variability from proxy data over the Common Era. The pseudoproxy framework has become a tool of choice for assessing the relative merits of such methods. Here we compare four variants of the RegEM algorithm [Schneider, 2001], using a pseudoproxy network mimicking the key spatio-temporal characteristics of the network of Mann et al., 2008 (hereinafter M08); the methods are (1) RegEM TTLS (2) RegEM iTTLS (3) GraphEM and (4) RegEM iRIDGE. To ensure continuity with previous work [Smerdon et al. 2011], pseudoproxy series are designed as a white-noise degraded version of the simulated temperature field [Amman et al. 2007] over 850-1980 C.E. colocated with 1138 M08 proxies. We use signal-to-noise ratios (SNRs) of: ∞ (no noise), 1.0, 0.5 and 0.25, to simulate differences in proxy quality. Two novelties in pseudoproxy design are introduced here: (1) the decrease in proxy availability over time follows that found in M08, (2) a realistic case where the SNR is empirically derived from correlations between each M08 proxy and the HadCRUT3v temperature field. It is found that this realistic SNR is clustered around 0.3, but ranges from 0.1 to 0.8. Verification statistics such as RE, CE, r2, bias, standard deviation ratio and RMSE are presented for each method at each SNR level. The results show that all methods perform relatively well at SNR levels higher than 0.5, but display drastically different performances at lower SNR levels. Compared with results using pseudoproxy network of Mann et al., 1998, (hereinafter MBH98), the reconstruction skill of the M08 network is relatively improved, in line with the findings of Smerdon et al., 2011. Overall, we find that GraphEM and iTTLS tend to produce more robust estimates of the temperature field at low SNR levels than other schemes, while preserving a higher amount of variance in the target field. Ammann, C. M., F

Serum levels of pancreatic stone protein (PSP/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY carriers from the third decade of life onward

Directory of Open Access Journals (Sweden)

Bacon Siobhan

2012-07-01

Full Text Available Abstract Background Mutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A result in the commonest type of maturity onset diabetes of the young (MODY. HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein/regenerating (PSP/reg gene in surviving neighbour cells, and that PSP/reg1A protein is subsequently secreted from these cells. The objective of this study was to determine whether serum levels of PSP/reg1A are elevated during disease progression in HNF1A-MODY carriers, and whether it may provide information regarding the onset of beta-cell apoptosis. Methods We analysed serum PSP/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY, and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed. Results PSP/reg1A serum levels were significantly elevated in HNF1A-MODY (n = 37 subjects compared to controls (n = 60 (median = 12.50 ng/ml, IQR = 10.61-17.87 ng/ml versus median = 10.72 ng/ml, IQR = 8.94-12.54 ng/ml, p = 0.0008. PSP/reg1A correlated negatively with insulin levels during OGTT, (rho = −0.40, p = 0.02. Interestingly we noted a significant positive correlation of PSP/reg1A with age of the HNF1A-MODY carriers (rho = 0.40 p = 0.02 with an age of 25 years separating carriers with low and high PSP/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP/reg1A compared to controls, however this was independent of the duration of diabetes. Conclusion Our data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25 years and over

Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward

LENUS (Irish Health Repository)

Bacon, Siobhan

2012-07-18

AbstractBackgroundMutations in the transcription factor hepatocyte nuclear factor-1-alpha (HNF1A) result in the commonest type of maturity onset diabetes of the young (MODY). HNF1A-MODY carriers have reduced pancreatic beta cell mass, partially due to an increased rate of apoptosis. To date, it has not been possible to determine when apoptosis is occurring in HNF1A-MODY.We have recently demonstrated that beta cell apoptosis stimulates the expression of the pancreatic stone protein\\/regenerating (PSP\\/reg) gene in surviving neighbour cells, and that PSP\\/reg1A protein is subsequently secreted from these cells. The objective of this study was to determine whether serum levels of PSP\\/reg1A are elevated during disease progression in HNF1A-MODY carriers, and whether it may provide information regarding the onset of beta-cell apoptosis.MethodsWe analysed serum PSP\\/reg1A levels and correlated with clinical and biochemical parameters in subjects with HNF1A-MODY, glucokinase (GCK-MODY), and type 1 diabetes mellitus. A control group of normoglycaemic subjects was also analysed.ResultsPSP\\/reg1A serum levels were significantly elevated in HNF1A-MODY (n = 37) subjects compared to controls (n = 60) (median = 12.50 ng\\/ml, IQR = 10.61-17.87 ng\\/ml versus median = 10.72 ng\\/ml, IQR = 8.94-12.54 ng\\/ml, p = 0.0008). PSP\\/reg1A correlated negatively with insulin levels during OGTT, (rho = −0.40, p = 0.02). Interestingly we noted a significant positive correlation of PSP\\/reg1A with age of the HNF1A-MODY carriers (rho = 0.40 p = 0.02) with an age of 25 years separating carriers with low and high PSP\\/reg1A levels. Patients with type 1 diabetes mellitus also had elevated serum levels of PSP\\/reg1A compared to controls, however this was independent of the duration of diabetes.ConclusionOur data suggest that beta cell apoptosis contributes increasingly to the pathophysiology of HNF1A-MODY in patients 25 years and

Chemical and radiation stability of SuperLig reg-sign 644, resorcinol-formaldehyde, and CS-100 cesium ion exchange materials

International Nuclear Information System (INIS)

Brown, G.N.; Adami, S.R.; Bray, L.A.

1995-09-01

At the request of the Initial Pretreatment Module Project within Westinghouse Hanford Company, Pacific Northwest Laboratory (PNL) conducted this study for the Efficient Separations and Processing Crosscutting Program (ESP) under the task ''Develop and Test Sorbents.'' The purpose of the study was to assess and compare the chemical and radiolytic stability of several cesium-selective ion exchange materials in simulated alkaline Hanford tank waste matrices. Pretreatment of nuclear process wastes to remove of cesium and other radionuclides by ion exchange was proposed previously as one method of minimizing the amount of high-level radioactive waste at Hanford. In this study, PNL evaluated three cesium-selective materials SuperLig reg-sign 644, resorcinol-formaldehyde (R-F), and CS-100 for chemical and radiation stability in 1 M NaOH and a simulated neutralized current acid waste (NCAW). The objective of the study is to investigate the stability of the newly produced SuperLig reg-sign 644 under a variety of conditions in an attempt to simulate and predict the degradation process. The following specific conclusions and recommendations resulted from the study

Chemical and radiation stability of SuperLig{reg_sign}644, resorcinol-formaldehyde, and CS-100 cesium ion exchange materials

Energy Technology Data Exchange (ETDEWEB)

Brown, G.N.; Adami, S.R.; Bray, L.A. [and others

1995-09-01

At the request of the Initial Pretreatment Module Project within Westinghouse Hanford Company, Pacific Northwest Laboratory (PNL) conducted this study for the Efficient Separations and Processing Crosscutting Program (ESP) under the task ``Develop and Test Sorbents.`` The purpose of the study was to assess and compare the chemical and radiolytic stability of several cesium-selective ion exchange materials in simulated alkaline Hanford tank waste matrices. Pretreatment of nuclear process wastes to remove of cesium and other radionuclides by ion exchange was proposed previously as one method of minimizing the amount of high-level radioactive waste at Hanford. In this study, PNL evaluated three cesium-selective materials SuperLig{reg_sign}644, resorcinol-formaldehyde (R-F), and CS-100 for chemical and radiation stability in 1 M NaOH and a simulated neutralized current acid waste (NCAW). The objective of the study is to investigate the stability of the newly produced SuperLig{reg_sign}644 under a variety of conditions in an attempt to simulate and predict the degradation process. The following specific conclusions and recommendations resulted from the study.

Vascular legacy: HOPE ADVANCEs to EMPA-REG and LEADER: A Surprising similarity

Directory of Open Access Journals (Sweden)

Sanjay Kalra

2017-01-01

Full Text Available Recently reported cardiovascular outcome studies on empagliflozin (EMPA-REG and liraglutide (LEADER have spurred interest in this field of diabetology. This commentary compares and contrasts these studies with two equally important outcome trials conducted using blood pressure lowering agents. A comparison with MICROHOPE (using ramipril and ADVANCE (using perindopril + indapamide blood pressure arms throws up interesting facts. The degree of blood pressure lowering, dissociation between cardiovascular and cerebrovascular benefits, and discordance between renal and retinal outcomes are surprisingly similar in these trials, conducted using disparate molecules. The time taken to achieve such benefits is similar for all drugs except empagliflozin. Such discussion helps inform rational and evidence-based choice of therapy and forms the framework for future research.

Precipitação sazonal sobre a Amazônia oriental no período chuvoso: observações e simulações regionais com o RegCM3 Seasonal precipitation in eastern Amazon during rainy season: regional observations and RegCM3 simulations

Directory of Open Access Journals (Sweden)

Everaldo B. de Souza

2009-06-01

Full Text Available O presente trabalho apresenta uma contribuição aos estudos de modelagem climática com ênfase na variabilidade pluviométrica sazonal da Amazônia oriental, durante as estações de verão e outono (DJF e MAM. Baseado nos resultados das simulações regionais do RegCM3 para um período de 26 anos (1982/83 a 2007/08 e usando domínio em alta resolução espacial (30 Km e dois diferentes esquemas de convecção (Grell e MIT, foi investigado o desempenho do modelo em simular a distribuição regional de precipitação sazonal na Amazônia oriental, com referência a um novo conjunto de dados observacional compilado com informações de uma ampla rede integrada de estações pluviométricas. As análises quantitativas evidenciaram que o RegCM3 apresenta erros sistemáticos, sobretudo aqueles relacionados com viés seco no Amapá e norte/nordeste do Pará usando ambos os esquemas Grell e MIT, os quais apontam que o modelo não reproduz as características da ZCIT sobre o Atlântico equatorial. As simulações usando MIT, também apresentaram viés úmido no sudoeste/sul/sudeste do Pará e norte do Tocantins. Além disso, através da técnica de composições, também foi investigado o desempenho do RegCM3 em reproduzir os padrões espaciais anômalos de precipitação sazonal em associação aos episódios ENOS, e as fases do gradiente térmico sobre o Atlântico intertropical. Os resultados demonstraram que o modelo conseguiu representar realisticamente bem o padrão espacial das anomalias pluviométricas acima (abaixo do normal em grande parte da Amazônia oriental, durante os conhecidos cenários favoráveis, i.e., condições de La Niña e gradiente de aTSM para o Atlântico sul (desfavoráveis, i.e., El Niño e gradiente de aTSM para o Atlântico norte.This paper presents a contribution on the climate modelling studies with emphasis on seasonal rainfall variability in eastern Amazonia, during the austral summer and autumn seasons (DJF and MAM

Impact assessment of WHO TobReg proposals for mandated lowering of selected mainstream cigarette smoke toxicants.

Science.gov (United States)

Eldridge, Alison C; McAdam, Kevin G; Betson, Tatiana R; Gama, Marcos V; Proctor, Christopher J

2017-06-01

The WHO Tobacco Product Regulation Study Group (TobReg) has proposed three regulatory models for cigarettes, each creating mandatory limits for emissions of nine smoke toxicants. One approach proposes country-specific limits, using median or 1.25× median toxicant/nicotine emission ratios. A second model provides fixed toxicant-ratio limits. The third model limits were three times the lowest toxicant emission on a market. Currently, the practical implications of these models are largely unknown. An impact assessment was conducted using cigarette data from 79 countries to identify four diverse test markets. We sampled all products from each market but limited product availability led to incomplete (80-97%) sourcing. Analysis showed that the country-specific model led to diverse (up to threefold) toxicant limits across the four markets. 70%-80% of products were non-compliant, rising to 100% in some countries with the second and the third models. With each regulatory model the main drivers of non-compliance were the tobacco-specific nitrosamines, the simultaneous application of limits for nine poorly correlated smoke toxicants, and analytical variability. Use of nicotine ratios led to compliance of some high toxicant emission products due to high nicotine emissions. Our findings suggest that these proposals would have greater impact on global markets than TobReg's stated aims. Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.

Demonstration of criticality safety for the modified TN-REG and TN-BRP transport/storage casks

International Nuclear Information System (INIS)

Parks, C.V.; Fox, P.B.

1989-01-01

An inability to model the structural performance of borated steel baskets under accident conditions forced the specially designed TN-BRP and TN-REG casks to be modified for half-loaded shipments. This paper discusses the approach used to demonstrate that the half-loaded casks would remain safely subcritical even if no credit were taken for the borated basket. Normal and accident configurations were analyzed with the KENO V.a code. The strategy conceived and the analyses performed to demonstrate an acceptable margin of safety are discussed. 5 refs., 3 figs., 2 tabs

Simulation of Relationship between ENSO and winter precipitation over Western Himalayas: Application of Regional climate model (RegT-Band)

Science.gov (United States)

Tiwari, P. R.; Mohanty, U. C.; Dey, S.; Acharaya, N.; Sinha, P.

2012-12-01

Precipitation over the Western Himalayas region during winter is mainly associated with the passage of midlatitude synoptic systems known as western disturbances (WDs). Recently, many observational and modeling studies reported that the relationship of the Indian southwest monsoon rainfall with El Niño- Southern Oscillation (ENSO) has weakened since around 1980. But, in contrast, only very few observational studies are reported so far to examine the relationship between ENSO and the winter precipitation over the Western Himalayas region from December to February (DJF). But there is a huge gap of modeling this phenomenon. So keeping in view of the absence of modeling studies, an attempt is made to simulate the relationship between wintertime precipitations associated with large scale global forcing of ENSO over the Western Himalayas. In the present study, RegT-Band, a tropical band version of the regional climate model RegCM4 is integrated for a set of 5 El Niño (1986-87, 1991-92, 1997-98, 2002-03, 2009-10) and 4 La Niña (1984-85, 1988-89, 1999-2000, 2007-08) years with the observed sea-surface temperature and lateral boundary condition. The domain extends from 50° S to 50° N and covers the entire tropics at a grid spacing of about 45 km, i.e. it includes lateral boundary forcing only at the southern and northern boundaries. The performance evaluation of the model in capturing the large scale fields followed by ENSO response with wintertime precipitation over the Western Himalayas region has been carried out by using National Center for Environmental Prediction (NCEP)-Department of Energy (DOE) reanalysis 2 (NNRP2) data (2.5° x 2.5°) and Aphrodite precipitation data (0.25° x 0.25°). The model is able to delineate the mean circulation associated with ENSO over the region during DJF reasonably well and shows strong southwesterly to northwesterly wind flow, which is there in verification analysis also. The vertical structure of the low as well as upper level

Assessing the effectiveness of RegCM4 regional climate model in simulating the aerosol optical depth patterns over the region of Eastern Mediterranean

Science.gov (United States)

Georgoulias, Aristeidis K.; Tsikerdekis, Athanasios; Ntogras, Christos; Zanis, Prodromos

2014-05-01

In this work, the ability of the regional climate model RegCM4 to simulate the aerosol optical depth (AOD) patterns over the region of Eastern Mediterranean is assessed. Three separate runs were implemented within the framework of the QUADIEEMS project for the time period 2000-2010 at a horizontal resolution of 50km covering the region of Europe. ERA-interim data were used as lateral boundary conditions while the model was driven by emissions from CMIP5. In the first case, the total of the aerosol types that RegCM4 accounts for were included (sulfate, black carbon, sea salt, dust), while in the other two cases only anthropogenic and dust particles were taken into account, respectively. The total AOD patterns were compared against level-2 satellite observations from MODIS TERRA and AQUA and ground-based measurements from 12 AERONET sites located in the region. In addition, the RegCM4 anthropogenic and dust AOD patterns were compared against the anthropogenic and dust component of MODIS AOD which was calculated using a combination of various satellite, model and reanalysis products. Our results indicate a significant underestimation of the anthropogenic AOD, while, on the contrary, the dust AOD fields are simulated in a more efficient way. The QUADIEEMS project is co-financed by the European Social Fund (ESF) and national resources under the operational programme Education and Lifelong Learning (EdLL) within the framework of the Action "Supporting Postdoctoral Researchers".

ROTO PEEN Scalar and VAC-PAC reg-sign system

International Nuclear Information System (INIS)

1998-02-01

The Pentek, Inc., milling technology, comprising the ROTO PEEN Scaler and the VAC-PAC reg-sign waste collection system, is a fully developed and commercialized technology used to remove hazardous coatings from concrete and steel floors, walls, ceilings, and structural components. This report describes a demonstration of the Pentek, Inc., milling system to remove the paint coating from 650 ft 2 of concrete flooring on the service floor of the Chicago Pile-5 (CP-5) Research Reactor. CP-5 is a heavy-water moderated and cooled, highly enriched, uranium-fueled thermal reactor designed to supply neutrons for research. The reactor had a thermal-power rating of 5 megawatts and was operated continuously for 25 years until its final shutdown in 1979. These 25 years of operation produced activation and contamination characteristics representative of other nuclear facilities within the Department of Energy (DOE) complex and the commercial nuclear sector. CP-5 contains many of the essential features of other DOE and commercial nuclear facilities and can be used safely as a demonstration facility for the evaluation of innovative technologies for the future D and D of much larger, more highly contaminated facilities

Bio-normalyzer[reg]: An anti-cancer drug for neuroblastoma?

International Nuclear Information System (INIS)

Gouget, B.; Sergeant, C.; Llabador, Y.; Simonoff, M.

2001-01-01

Iron is an essential micronutrient required for cell division and growth. Incorporation of iron into cells is achieved by endocytosis of transferrin. Then, iron may be stored in ferritin and hemosiderin. Increased intracellular iron concentrations may promote malignant cell growth. Patients with advanced-stage neuroblastoma (NB) show abnormally high levels of serum ferritin, very likely synthesized and secreted by the tumor in vivo and consistent with a frequent accumulation of iron in ferritin in NB tumor tissues. In a previous study, we showed that there is no iron accumulation in cultured neuroblasts, and intracellular iron concentrations proved to be especially low. Bio-Normalizer[reg] (BioN) is a nutritional supplement sold to be an anti-oxidant and metal-chelator. In the present study, we tested cell viability and measured iron concentrations in neuroblasts treated or not with BioN. We found that BioN, probably thanks to papain, presents an anti-proliferative effect on NB cultured cells. Besides, preliminary results tend to prove that this natural anti-oxidant and iron-chelator could present interesting effects on trace metal concentrations in neuroblasts. Such a compound may be useful in treatment of this pathology

La política de la protesta en regímenes autoritarios: síntesis crítica

Directory of Open Access Journals (Sweden)

Felipe Sánchez Barría

Full Text Available RESUMEN Introducción A través de una revisión crítica de la literatura reciente, el ensayo explora la relación entre protesta contenciosa y regímenes autoritarios, y examina las dinámicas y consecuencias que emergen durante el conflicto político. Métodos Para lo anterior se discuten tres elementos que los especialistas han identificado como los principales en esta relación: oportunidades y amenazas políticas; ciclos de protesta y sostenibilidad de los movimientos sociales; y la relación entre violencia estatal y acción colectiva. Resultados La recurrencia de la protesta en regímenes represivos muestra la capacidad de la sociedad civil para articular este tipo de acciones contenciosas. Discusión No obstante, las trayectorias y resultados dependen, por una parte, de las características políticas del régimen y la competencia del gobierno para responder a los desafíos colectivos; y, por otra parte, de la capacidad de los oponentes de montar ciclos de protestas densos en participación durante un periodo significativo, del tipo de tácticas adoptadas, y de la capacidad de adaptación y resiliencia a la violencia estatal.

Application of NUHOMS reg-sign to an integrated MRS/transportation system

International Nuclear Information System (INIS)

Rosa, J.M.; Lehnert, R.A.; Quinn, R.D.

1992-01-01

Storage of spent fuel at reactor sites in weld sealed canisters has been increasing steadily since 1989, with three facilities now having ISFSIs which employ the NUHOMS reg-sign technology. Expansion of existing Independent Spent Fuel Storage Installations (ISFSIs) and implementation of new ones will result in a substantial fraction of the at-reactor spent fuel inventory in dry storage canisters by 1998 and beyond. Since this same technology is readily applicable to the MRS, it is advantageous to transfer canisters directly from the ISFSI to the MRS for storage there without the need to reopen the canisters or rehandle the fuel. A store-only MRS offers the possibility of a simple, economical facility which can more easily be demonstrated to be temporary and environmentally benign. Transportation of an intact canister is feasible in a shipping cask of conventional design that is compatible with existing railcars and railroad interchange rules. The use of canisterized fuel also has advantages for eventual shipment and disposal at the federal repository

La insurgencia reprimida. Regímenes de Seguridad Nacional contra la revolución

Directory of Open Access Journals (Sweden)

Pedro Rivas Nieto

2010-01-01

Full Text Available En este artículo se estudia tanto el concepto que los regímenes de Seguridad Nacional tenían de la llamada guerra revolucionaria como la respuesta que le dieron. Allá en donde implantaron su dominio -especialmente en el Cono Sur de América- pensaban que las guerras revolucionarias eran nuevas técnicas de lucha más que un tipo definido de guerra, que todas respondían al mismo modelo revolucionario y que eran la estrategia del comunismo internacional para adueñarse del mundo. Por eso atacaron con especial dureza a los movimientos de izquierda, pensando que eran la avanzadilla moscovita para acabar con las democracias latinoamericanas.

Implementation of the NANoREG Safe-by-Design approach for different nanomaterial applications

International Nuclear Information System (INIS)

Micheletti, C; Roman, M; Tedesco, E; Olivato, I; Benetti, F

2017-01-01

The Safe-by-Design (SbD) concept is already in use in different industrial sectors as an integral part of the innovation process management. However, the adopted approach is often limited to design solutions aiming at hazard reduction. Safety is not always considered during the innovation process, mainly due to the lack of knowledge (e.g. in small and medium companies, SMEs) and the lack of dialogue between actors along the innovation chain. The net result is that safety is considered only at the end of the innovation process at the market authorization phase, with potential loss of time and money. This is especially valid for manufactured nanomaterials (MNM) for which the regulatory context is not completely developed, and the safety knowledge is not readily available. In order to contribute to a sustainable innovation process in the nanotechnology field by maximising both benefits and safety, the NANoREG project developed a Safe Innovation approach, based on two elements: the Safe-by-Design approach which aims at including risk assessment into all innovation stages; and the Regulatory Preparedness, focused on the dialogue with stakeholders along the innovation chain. In this work we present some examples about the implementation in our Laboratory of this approach for different MNM applications, covering different steps of the innovation chain. The case studies include: the feasibility study of a medical device including substances, for topical application; the testing of two potential nanotech solutions for the consolidation of cultural heritage artifacts; the testing of coatings already on the market for other uses, which was tested as food contact materials (FCM) to evaluate the conformity to food applications. These three examples represent a good opportunity to show the importance of NANoREG SbD and Safe Innovation Approach in general, for developing new nanotechnology-based products, also highlighting the crucial role of EU ProSafe project in promoting this

Implementation of the NANoREG Safe-by-Design approach for different nanomaterial applications

Science.gov (United States)

Micheletti, C.; Roman, M.; Tedesco, E.; Olivato, I.; Benetti, F.

2017-06-01

The Safe-by-Design (SbD) concept is already in use in different industrial sectors as an integral part of the innovation process management. However, the adopted approach is often limited to design solutions aiming at hazard reduction. Safety is not always considered during the innovation process, mainly due to the lack of knowledge (e.g. in small and medium companies, SMEs) and the lack of dialogue between actors along the innovation chain. The net result is that safety is considered only at the end of the innovation process at the market authorization phase, with potential loss of time and money. This is especially valid for manufactured nanomaterials (MNM) for which the regulatory context is not completely developed, and the safety knowledge is not readily available. In order to contribute to a sustainable innovation process in the nanotechnology field by maximising both benefits and safety, the NANoREG project developed a Safe Innovation approach, based on two elements: the Safe-by-Design approach which aims at including risk assessment into all innovation stages; and the Regulatory Preparedness, focused on the dialogue with stakeholders along the innovation chain. In this work we present some examples about the implementation in our Laboratory of this approach for different MNM applications, covering different steps of the innovation chain. The case studies include: the feasibility study of a medical device including substances, for topical application; the testing of two potential nanotech solutions for the consolidation of cultural heritage artifacts; the testing of coatings already on the market for other uses, which was tested as food contact materials (FCM) to evaluate the conformity to food applications. These three examples represent a good opportunity to show the importance of NANoREG SbD and Safe Innovation Approach in general, for developing new nanotechnology-based products, also highlighting the crucial role of EU ProSafe project in promoting this

A sensitive pressure sensor for diamond anvil cell experiments up to 2 GPa: FluoSpheres[reg

International Nuclear Information System (INIS)

Picard, Aude; Oger, Phil M.; Daniel, Isabelle; Cardon, Herve; Montagnac, Gilles; Chervin, Jean-Claude

2006-01-01

We present an optical pressure sensor suitable for experiments in diamond anvil cell in the 0.1 MPa-2 GPa pressure range, for temperatures between ambient and 323 K. It is based on the pressure-dependent fluorescence spectrum of FluoSpheres[reg], which are commercially available fluorescent microspheres commonly used to measure blood flow in experimental biology. The fluorescence of microspheres is excited by the 514.5 nm line of an Ar + laser, and the resulting spectrum displays three very intense broad bands at 534, 558, and 598 nm, respectively. The reference wavelength and pressure gauge is that of the first inflection point of the spectrum, located at 525.6±0.2 nm at ambient pressure. It is characterized by an instantaneous and large linear pressure shift of 9.93(±0.08) nm/GPa. The fluorescence of the FluoSpheres[reg] has been investigated as a function of pressure (0.1-4 GPa), temperature (295-343 K), pH (3-12), salinity, and pressure transmitting medium. These measurements show that, for pressures comprised between 0.1 MPa and 2 GPa, at temperatures not exceeding 323 K, at any pH, in aqueous pressure transmitting media, pressure can be calculated from the wavelength shift of two to three beads, according to the relation P=0.100 (±0.001) Δλ i (P) with Δλ i (P)=λ i (P)-λ i (0) and λ i (P) as the wavelength of the first inflection point of the spectrum at the pressure P. This pressure sensor is approximately thirty times more sensitive than the ruby scale and responds instantaneously to pressure variations

Efecto de diferentes regímenes de fertilización sobre la relación fitoplancton-bacteríoplancton en mesocosmos

OpenAIRE

Monserrate Vite, Marita Elizabeth

2003-01-01

Efecto de diferentes regímenes de fertilización sobre la relación fitoplancton-bacterioplancton en mesocosmos Se estudió el efecto de la adición de fertilizantes inorgánicos y orgánicos sobre la relación bacterioplancton – fitoplancton en mesocosmos (24 tanques de una tonelada de capacidad), llenados con agua del canal reservorio de la camaronera COFIMAR (Palmar, Ecuador).

Thermal expansion studies on Inconel-600[reg] by high temperature X-ray diffraction

International Nuclear Information System (INIS)

Raju, S.; Sivasubramanian, K.; Divakar, R.; Panneerselvam, G.; Banerjee, A.; Mohandas, E.; Antony, M.P.

2004-01-01

The lattice thermal expansion characteristics of Inconel-600[reg] have been studied by high temperature X-ray diffraction (HT-XRD) technique in the temperature range 298-1200 K. Altogether four experimental runs were conducted on thin foils of about 75-100 μm thickness. The diffraction profiles have been accurately calibrated to offset the shift in 2θ values introduced by sample buckling at elevated temperatures. The corrected lattice parameter data have been used to estimate the instantaneous and mean linear thermal expansion coefficients as a function of temperature. The thermal expansion values estimated in the present study show a fair degree of agreement with other existing dilatometer based bulk thermal expansion estimates. The lattice parameter for this alloy at 300 K is found to be 0.3549(1) nm. The mean linear thermal expansivity is found to be 11.4 x 10 -6 K -1

The effect of flurprimidol on Allium rosenbachianum Reg. forced in pots

Directory of Open Access Journals (Sweden)

Halina Laskowska

2013-04-01

Full Text Available The effect of flurprimidol on Allium rosenbachianum (Reg. flowering and forcing period was studied. Bulbs of 18-20 cm circumference were used in the experiment. Two methods of retardant application were used: bulbs soaking before planting and triple spraying of plants during the vegetation period (in the stage of leaf rosette, open leaves and in the phase of green, ‘sitting’ bud. Flurprimidol was used in the following doses: 15 mg ∙dm -3 , 30 mg ∙dm -3 , 45 mg ∙dm -3 and control (plants treated with distilled water. Bulbs were planted into pots on the 20 th of October and ‘wet cooled’ for 14 weeks in the temperature of 9°C. During forcing in a greenhouse, morphological features of plants were observed. It was noted that flurprimidol may be effectively used for suppressing A. rosenbachianum forced in a greenhouse as a pot plant. Flurprimidol used in concentration of 45 mg ∙dm -3 significantly inhibited growth of shoots and length of flower pedicels and leaves and increased number of flowers in inflorescences at the same time. Soaking bulbs of A. rosenbachianumin flurprimidol solution before planting shortened forcing period by 4 days.

Establishment of the National Nuclear Regulatory Portal (NNRP) as the key element of the Global Nuclear Safety and Security Network and Regulatory Network (GNSSN/RegNet) for sharing of nuclear safety information and knowledge among the Global Expert Community

International Nuclear Information System (INIS)

Kuvshinnikov, A.V.

2011-01-01

The Global Nuclear Safety and Security Network (GNSSN) implements the concept of the Global Nuclear Safety and Security Framework (GNSSF) as outlined in INSAG 21. This is the framework of instruments and resources for achieving and maintaining worldwide a high level of safety and security at nuclear facilities and activities as stated in SF-1 and supporting safety standards or recommendations such as INSAG-12. National efforts are and should be augmented by the activities of a variety of international enterprises that facilitate safety and security. The IAEA standard GS-R-3 requires that information and knowledge is managed as a resource. Further strengthening of GNSSN in particular regulatory networking as intended by GNSSN/RegNet has to be based on current national priorities, on existing regional and thematic networks and on the established mechanisms of international co-operation as presented for example on the websites of the IAEA or the OECD-NEA. Current design and operation of RegNet are flexible enough to accommodate differences in national and international approaches and practices and to facilitate exchange and cooperation on regulatory matters. The main role of GNSSN/RegNet is sharing knowledge and bringing people together to enhance and promote nuclear safety and security. The objectives of GNSSN/RegNet: enhancing safety and security by international cooperation, sharing information and best practices, enabling adequate access to relevant safety and security information and promoting the dissemination of this information, implementing active collaboration in the relevant areas related to safety and security, such as joint projects, peer reviews, enabling synergies among existing networks and initiatives, informing the public on the relevant safety and security areas and the related international collaboration. In the RegNet part of the GNSSN exist the National Nuclear Regulatory Portal (NNRP) which is on one hand a part of the global RegNet and on the

Creating field management information systems using microsoft{reg_sign} software

Energy Technology Data Exchange (ETDEWEB)

Handsel-Johnson, P.L.; Schroeder, C.Y.

1995-12-31

A Field management information system (FMIS) was created for the Trinidad Resource Development teams in Amoco`s Intemational Operations Group. This application uses Microsoft Access {reg_sign}2.0 and the other Microsoft Office 4.2 software products. The purpose of this information system is to assist these teams in the management of their producing oil and gas fields. This is accomplished by providing: (1) centralized data storage for a variety of data, such as well, production, engineering and geologic in various forms, including raw, interpreted and derived, (2) customized analysis, planning and reporting tools, such as reservoir performance summaries and dynamic field management plans, and (3) the capability to easily exchange data with a variety of engineering and geoscience analytical software. Additional benefits provided to the Resource Development teams by this approach are: (1) improved data accuracy and accessibility from a centralized, relational database, (2) enhanced efficiency as a result of the application being tailored to the teams` operating environment and work processes, and (3) access to an expanded knowledge base by consolidating information from several fields into one database. In short, this product was developed in response to the Trinidad Resource Development teams` need to improve their data integrity, efficiency and analysis and planning capability. The resultant application is not just a database, but rather, a field management information system.

Projected effects of vegetation feedbacks on drought characteristics with SPEI over West Africa using the RegCM-CLM-CN-DV

Science.gov (United States)

Jaehyeong, L.; Kim, Y.; Erfanian, A.; Wang, G.; Um, M. J.

2017-12-01

This study utilizes the Standardized Precipitation-Evapotranspiration Index (SPEI) to investigate the projected effect of vegetation feedbacks on drought in West Africa using the Regional Climate Model coupled to the NCAR Community Land Model with both the Carbon and Nitrogen module (CN) and Dynamic Vegetation module (DV) activated (RegCM-CLM-CN-DV). The role of vegetation feedbacks is examined based on simulations with and without dynamic vegetation. The four different future climate scenarios from CCSM, GFDL, MIROC and MPI are used as the boundary conditions of RegCM for two historical and future periods, i.e., for 1981 to 2000 and for 2081 to 2100, respectively. Using SPEI, the duration, frequency, severity and spatial extents are quantified over West Africa and analyzed for two regions of the Sahel and the Gulf of Guinea. In this study, we find that the estimated annual SPEIs clearly indicate that the projected future droughts over the Sahel are enhanced and prolonged when DV is activated. The opposite is shown over the Gulf of Guinea in general. AcknowledgementsThis work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (2015R1C1A2A01054800), by the Korea Meteorological Administration R&D Program under Grant KMIPA 2015-6180 and by the Yonsei University Future-leading Research Initiative of 2015(2016-22-0061).

Die reg op lewe

Directory of Open Access Journals (Sweden)

J.M. Vorster

2002-08-01

Full Text Available The right to life This article deals with the practical application of the fundamental right to life with special focus on abortion, capital punishment and euthanasia. From a Christian ethical perspective and the biblical principle of life it is argued that the practice of abortion, capital punishment and euthanasia cannot be justified for various reasons. Christians should therefore consider other ways to deal with issues like unwanted pregnancies and suffering. Regarding serious crime, punitive measures other than capital punishment ought to be considered because the practice of capital punishment can be misused by the state and can lead to the abuse of power. Capital punishment is also detrimental to the development of a culture of respect for life in society at large.

Anti-IL-2 treatment impairs the expansion of T(reg cell population during acute malaria and enhances the Th1 cell response at the chronic disease.

Directory of Open Access Journals (Sweden)

Cláudia A Zago

Full Text Available Plasmodium chabaudi infection induces a rapid and intense splenic CD4(+ T cell response that contributes to both disease pathogenesis and the control of acute parasitemia. The subsequent development of clinical immunity to disease occurs concomitantly with the persistence of low levels of chronic parasitemia. The suppressive activity of regulatory T (T(reg cells has been implicated in both development of clinical immunity and parasite persistence. To evaluate whether IL-2 is required to induce and to sustain the suppressive activity of T(reg cells in malaria, we examined in detail the effects of anti-IL-2 treatment with JES6-1 monoclonal antibody (mAb on the splenic CD4(+ T cell response during acute and chronic P. chabaudi AS infection in C57BL/6 mice. JES6-1 treatment on days 0, 2 and 4 of infection partially inhibits the expansion of the CD4(+CD25(+Foxp3(+ cell population during acute malaria. Despite the concomitant secretion of IL-2 and expression of high affinity IL-2 receptor by large CD4(+ T cells, JES6-1 treatment does not impair effector CD4(+ T cell activation and IFN-γ production. However, at the chronic phase of the disease, an enhancement of cellular and humoral responses occurs in JES6-1-treated mice, with increased production of TNF-α and parasite-specific IgG2a antibodies. Furthermore, JES6-1 mAb completely blocked the in vitro proliferation of CD4(+ T cells from non-treated chronic mice, while it further increased the response of CD4(+ T cells from JES6-1-treated chronic mice. We conclude that JES6-1 treatment impairs the expansion of T(reg cell population during early P. chabaudi malaria and enhances the Th1 cell response in the late phase of the disease.

A comparative evaluation of IONSIV reg-sign IE-911 and chabazite zeolite for the removal of radiostrontium and cesium from wastewater

International Nuclear Information System (INIS)

Bostick, D.T.; DePaoli, S.M.; Guo, B.

1998-01-01

Natural chabazite zeolite was selected as the baseline treatment technology for the removal of fission products, namely 90 Sr and 137 Cs, from near-neutral-pH process wastewater and groundwater. The sorbent IONSIV reg-sign IE-911, a crystalline silicotitanate manufactured by UOP, was recently tested in this capacity and found to compare extremely well against the baseline material. This paper presents and compares the results of similar batch and column tests performed using both materials, and summarizes the physical and chemical characteristics of the sorbents

Regional climate modeling over the Maritime Continent: Assessment of RegCM3-BATS1e and RegCM3-IBIS

Science.gov (United States)

Gianotti, R. L.; Zhang, D.; Eltahir, E. A.

2010-12-01

Despite its importance to global rainfall and circulation processes, the Maritime Continent remains a region that is poorly simulated by climate models. Relatively few studies have been undertaken using a model with fine enough resolution to capture the small-scale spatial heterogeneity of this region and associated land-atmosphere interactions. These studies have shown that even regional climate models (RCMs) struggle to reproduce the climate of this region, particularly the diurnal cycle of rainfall. This study builds on previous work by undertaking a more thorough evaluation of RCM performance in simulating the timing and intensity of rainfall over the Maritime Continent, with identification of major sources of error. An assessment was conducted of the Regional Climate Model Version 3 (RegCM3) used in a coupled system with two land surface schemes: Biosphere Atmosphere Transfer System Version 1e (BATS1e) and Integrated Biosphere Simulator (IBIS). The model’s performance in simulating precipitation was evaluated against the 3-hourly TRMM 3B42 product, with some validation provided of this TRMM product against ground station meteorological data. It is found that the model suffers from three major errors in the rainfall histogram: underestimation of the frequency of dry periods, overestimation of the frequency of low intensity rainfall, and underestimation of the frequency of high intensity rainfall. Additionally, the model shows error in the timing of the diurnal rainfall peak, particularly over land surfaces. These four errors were largely insensitive to the choice of boundary conditions, convective parameterization scheme or land surface scheme. The presence of a wet or dry bias in the simulated volumes of rainfall was, however, dependent on the choice of convection scheme and boundary conditions. This study also showed that the coupled model system has significant error in overestimation of latent heat flux and evapotranspiration from the land surface, and

The Fluorine Gauche Effect Explained by Electrostatic Polarization Instead of Hyperconjugation: An Interacting Quantum Atoms (IQA) and Relative Energy Gradient (REG) Study

OpenAIRE

Thacker, Joseph; Popelier, Paul

2018-01-01

We present an interacting quantum atoms (IQA) study of the gauche effect by comparing 1,2-difluoroethane, 1,2-dichloroethane, and three conformers of 1,2,3,4,5,6-hexafluorocyclohexane. In the 1,2-difluoroethane, the gauche effect is observed in that the gauche conformation is more stable than the anti, whereas in 1,2-dichloroethane the opposite is true. The analysis performed here is exhaustive and unbiased thanks to using the recently introduced relative energy gradient (REG) method [Thacker...

Assessment of TEES{reg_sign} applications for Wet Industrial Wastes: Energy benefit and economic analysis report

Energy Technology Data Exchange (ETDEWEB)

Elliott, D.C.; Scheer, T.H.

1992-02-01

Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg_sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

Assessment of TEES reg sign applications for Wet Industrial Wastes: Energy benefit and economic analysis report

Energy Technology Data Exchange (ETDEWEB)

Elliott, D.C.; Scheer, T.H.

1992-02-01

Fundamental work is catalyzed biomass pyrolysis/gasification led to the Thermochemical Environmental Energy System (TEES{reg sign}) concept, a means of converting moist biomass feedstocks to high-value fuel gases such as methane. A low-temperature (350{degrees}C), pressurized (3100 psig) reaction environment and a nickel catalyst are used to reduce volumes of very high-moisture wastes such as food processing byproducts while producing useful quantities of energy. A study was conducted to assess the economic viability of a range of potential applications of the process. Cases examined included feedstocks of cheese whey, grape pomace, spent grain, and an organic chemical waste stream. The analysis indicated that only the organic chemical waste process is economically attractive in the existing energy/economic environment. However, food processing cases will become attractive as alternative disposal practices are curtailed and energy prices rise.

Applicability of 1994-1995 USRADS reg-sign surveys of Bear Creek Valley flood plain and Operable Unit 1 to the radiological characterization of Y-12 grassy/wooded areas

International Nuclear Information System (INIS)

Bogard, J.S.; Hamm, R.N.; Brown, K.S.

1997-03-01

This document, provided in support of the Y-12 Site Radiological Characterization Study, analyzes the utility of data from two reports by Chemrad Tennessee Corporation in identifying radiological contamination in excess of contamination control guidelines at the surface of soils in the Bear Creek Valley Flood Plain (BCVFP) and in Y-12 Operable Unit 1 (OU1). The Chemrad reports were developed under subcontract to Science Applications International Corporation for their remedial investigation of these sites for Martin Marietta Energy Systems Environmental Restoration Division. Surveys were performed by Chemrad using the UltraSonic Ranging and Data System (USRADS reg-sign), which utilizes ultrasonic triangulation to determine the location of a survey technician at the same time that radiological monitoring data are telemetered from his instruments to a remote receiving station. Floor monitor and Geiger-Mueller pancake meter results from the USRADS reg-sign surveys are shown to be sufficiently precise to reliably detect contamination in excess of the limiting radioactivity value of 1,000 dpm/100 cm 2 for removable uranium contamination specified in 10 CFR 835 Appendix D. MicroRem meter survey results, also included as part of the USRADS reg-sign surveys, indicate that the derived limiting value of 56.8 μrem/h for penetrating dose at 1 m (corresponding to 100 mrem/γ) was not exceeded. However, both the pancake meter and floor monitor results suggest that surface contamination exceeding 1,000 dpm/100 cm 2 is not uncommon. Sites in OU1 and BCVFP were visited, and independent surveys made with hand-held instruments, to confirm conclusions about the USRADS close-quote survey results and to verify that these results are from contamination uniformly distributed on the soil surface, and not from discrete sources which are not likely transferred to shoes, vehicles, or clothing

Measurement and modeling of residual stress in a welded Haynes[reg] 25 cylinder

International Nuclear Information System (INIS)

Larsson, C.; Holden, T.M.; Bourke, M.A.M.; Stout, M.; Teague, J.; Lindgren, L.-E.

2005-01-01

An experimental and simulation study of residual stresses was made in the vicinity of a gas tungsten arc weld, used to join a hemispherical end cap to a cylinder. The capped cylinder is used in a satellite application and was fabricated from a Co-based Haynes[reg] 25 alloy. The cylinder was 34.7 mm in outer diameter and 3.3 mm in thickness. The experimental measurements were made by neutron diffraction and the simulation used the implicit Marc finite element code. The experimental resolution was limited to approximately 3 mm parallel to the axis of the cylinder (the weld was 6 mm in the same direction) and comparison over the same volume of the finite element prediction showed general agreement. Subject to the limited spatial resolution, the largest experimentally measured tensile residual stress was 180 MPa, located at the middle of the weld. However, the predictions suggest that there are regions in the weld where average tensile residual stresses as much as 400 MPa exist. One qualitative disparity between the model and the experiments was that the measurement included a larger degree of asymmetry on either side of the weld than predicted by the model

Measurement and modeling of residual stress in a welded Haynes[reg] 25 cylinder

Energy Technology Data Exchange (ETDEWEB)

Larsson, C. [Div. of Eng. Mat., Department of Mech. Eng., Linkoeping University, 58183 Linkoeping (Sweden)]. E-mail: clarsson@cfl.rr.com; Holden, T.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Bourke, M.A.M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Stout, M. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Teague, J. [Los Alamos National Laboratory, Los Alamos, NM 87545 (United States); Lindgren, L.-E. [Div. Comp. Aided Design, Lulea University of Technology and Dalarna University, 97187 Lulea (Sweden)

2005-06-15

An experimental and simulation study of residual stresses was made in the vicinity of a gas tungsten arc weld, used to join a hemispherical end cap to a cylinder. The capped cylinder is used in a satellite application and was fabricated from a Co-based Haynes[reg] 25 alloy. The cylinder was 34.7 mm in outer diameter and 3.3 mm in thickness. The experimental measurements were made by neutron diffraction and the simulation used the implicit Marc finite element code. The experimental resolution was limited to approximately 3 mm parallel to the axis of the cylinder (the weld was 6 mm in the same direction) and comparison over the same volume of the finite element prediction showed general agreement. Subject to the limited spatial resolution, the largest experimentally measured tensile residual stress was 180 MPa, located at the middle of the weld. However, the predictions suggest that there are regions in the weld where average tensile residual stresses as much as 400 MPa exist. One qualitative disparity between the model and the experiments was that the measurement included a larger degree of asymmetry on either side of the weld than predicted by the model.

Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

Science.gov (United States)

Colorado SIP: 5 CCR 1001-13, Reg 11, Motor Vehicle Emissions Inspection Program—Part A, General Provisions, Area of Applicability, Schedules for Obtaining Certification of Emissions Control, Definitions, Exemptions, and Clean Screening/Remote Sensing

Cuestión social y regímenes militares. Argentina y Chile durante los años setenta

Directory of Open Access Journals (Sweden)

Gabriela Gomes

2015-01-01

Full Text Available En este artículo se analizan las políticas sociales destinadas a la búsqueda del consenso que llevaron adelante la Secretaría de Estado de Promoción y Asistencia a la Comunidad del Ministerio de Bienestar Social durante la “Revolución Argentina” (1966-1973 y la Dirección de Organizaciones Civiles y el Ministerio del Interior durante la dictadura chilena (1973-1988. El abordaje propuesto apunta a complejizar la noción de Estado burocrático autoritario, puesto que se considera como hipótesis que ambos regímenes no solo se dedicaron a reprimir las actividades políticas de los sectores populares, sino que buscaron reorganizarlos bajo nuevas coordenadas sociales.

La marea autoritaria: nacimiento, desarrollo y consolidación de regímenes parafascistas en Austria y España

Directory of Open Access Journals (Sweden)

Miguel Ángel del Arco Blanco

2009-12-01

Full Text Available En el presente trabajo se explica el nacimiento y propagación de los movimientos fascistas a partir de las secuelas de la I Guerra Mundial y del escenario político y social que le siguió. Los casos que analizamos en el presente trabajo, Austria y España, encajan perfectamente en ese contexto; y de ello deriva el interés de su estudio para la comprensión de la llegada e implantación del fascismo en Europa, así como del parafascismo (regímenes que, aunque no fueron plenamente fascistas, sí compartieron algunas características y fueron fuertemente influenciados por el fascismo en su nacimiento, implantación y consolidación. El análisis y comparación de regímenes como el Ständestaat y el franquista quizá pongan de manifiesto que el parafascismo pudo ser más la norma que la excepción a la alternativa plenamente fascista en la Europa de entreguerras.______________________ABSTRACT:The present work tries to explain the birth and the spread of facist movements from the consequences of theFirst World War and the political and social scene that followed it. The cases that we analyzed in this work, Austria and Spain, fit perfectly in that context; this kind of analysis facilitates the understanding of the coming and implantation of fascism in Europe, as well as of parafascism phenomenon (a kind of regime that, although is not totally facist, it shares some characteristics and is strongly influenced by the fascism in its birth, implantation and consolidation. The analysis and comparison of regimes just as the Ständestaat and the Franquista's one can show that the parafascism could be the norm in lieu of the exception to the totally facist alternative in the inter-war Europe.

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Science.gov (United States)

Rocklin, Delphine; Tomasini, Jean-Antoine; Culioli, Jean-Michel; Pelletier, Dominique; Mouillot, David

2011-01-01

The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA) and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR), a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE) increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1) in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Spearfishing regulation benefits artisanal fisheries: the ReGS indicator and its application to a multiple-use Mediterranean marine protected area.

Directory of Open Access Journals (Sweden)

Delphine Rocklin

Full Text Available The development of fishing efficiency coupled with an increase of fishing effort led to the overexploitation of numerous natural marine resources. In addition to this commercial pressure, the impact of recreational activities on fish assemblages remains barely known. Here we examined the impact of spearfishing limitation on resources in a marine protected area (MPA and the benefit it provides for the local artisanal fishery through the use of a novel indicator. We analysed trends in the fish assemblage composition using artisanal fisheries data collected in the Bonifacio Strait Natural Reserve (BSNR, a Mediterranean MPA where the spearfishing activity has been forbidden over 15% of its area. Fish species were pooled into three response groups according to their target level by spearfishing. We developed the new flexible ReGS indicator reflecting shifts in species assemblages according to the relative abundance of each response group facing external pressure. The catch per unit effort (CPUE increased by ca. 60% in the BSNR between 2000 and 2007, while the MPA was established in 1999. The gain of CPUE strongly depended on the considered response group: for the highly targeted group, the CPUE doubled while the CPUE of the untargeted group increased by only 15.5%. The ReGS value significantly increased from 0.31 to 0.45 (on a scale between 0 and 1 in the general perimeter of this MPA while it has reached a threshold of 0.43, considered as a reference point, in the area protected from spearfishing since 1982. Our results demonstrated that limiting recreational fishing by appropriate zoning in multiple-use MPAs represents a real benefit for artisanal fisheries. More generally we showed how our new indicator may reveal a wide range of impacts on coastal ecosystems such as global change or habitat degradation.

Regulatory T cells predict the time to initial treatment in early stage chronic lymphocytic leukemia.

Science.gov (United States)

Weiss, Lukas; Melchardt, Thomas; Egle, Alexander; Grabmer, Christoph; Greil, Richard; Tinhofer, Inge

2011-05-15

Early stage chronic lymphocytic leukemia is characterized by a highly variable course of disease. Because it is believed that regulatory T cells (T(regs) ) are potent suppressors of antitumor immunity, the authors hypothesized that increased T(regs) may favor disease progression. T(reg) levels (cluster of differentiation 3 [CD3]-positive, [CD4]-positive, CD25-positive, and CD127-negative) in peripheral blood from 102 patients were analyzed by flow cytometry. Statistical analysis was used to evaluate correlations with clinical data. The relative T(reg) numbers in CD4-positive T cells were significantly greater in patients with chronic lymphocytic leukemia compared with the numbers in a control group of 170 healthy individuals (P = .001). Patients were divided into 2 groups using a median T(reg) value of 9.7% (the percentage of CD4-positive T cells). Patients with higher T(reg) levels had a significantly shorter time to initial treatment (median, 5.9 years) compared with patients who had lower T(reg) levels (median, 11.7 years; log-rank P = .019). Furthermore, T(reg) levels (the percentage of CD4-positive T cells) had significant prognostic power to predict the time to initial treatment in univariate analysis (P = .023) and in multivariate Cox regression analysis that included the variables Rai stage, immunoglobulin heavy-chain variable region gene mutational status, chromosomal aberrations, and CD38 expression (P = .028). Higher T(reg) levels had significant and independent prognostic power for predicting the time to initial treatment in patients with low to intermediate stage chronic lymphocytic leukemia. 2010 American Cancer Society.

Electron spin resonance characterization of trapping centers in Unibond reg-sign buried oxides

International Nuclear Information System (INIS)

Conley, J.F. Jr.; Lenahan, P.M.; Wallace, B.D.

1996-01-01

Electron spin resonance and capacitance vs. voltage measurements are used to evaluate the radiation response of Unibond buried oxides. When damaged by hole injection, it is found that Unibond reg-sign buried oxides exhibit a rough correspondence between E' centers and positive charge as well as generation of P b centers at the Unibond buried oxide/Si interface. In these respects, Unibond buried oxides qualitatively resemble thermal SiO 2 . However, a hydrogen complexed E' center known as the 74 G doublet is also detected in the Unibond buried oxides. This defect is not detectable in thermal SiO 2 under similar circumstances. Since the presence of 74 G doublet center is generally indicative of very high hydrogen content and since hydrogen is clearly a significant participant in radiation damage, this result suggests a qualitative difference between the radiation response of Unibond and thermal SiO 2 . Unibond results are also compared and contrasted with similar investigations on separation-by-implanted-oxygen (SIMOX) buried oxides. Although the charge trapping response of Unibond buried oxides may be inferior to that of radiation hardened thermal SiO 2 , it appears to be more simple and superior to that of SIMOX buried oxides

Regímenes estacionales de precipitación en la vertiente mediterránea de la Península Ibérica

OpenAIRE

Luis Arrillaga, Martín de; González Hidalgo, José Carlos; Longares, Luis Alberto; Stepanek, Petr

2008-01-01

Ponencia presentada en: VI Congreso Internacional de la Asociación Española de Climatología celebrado en Tarragona del 8 al 11 de octubre de 2008. [ES]En este trabajo analizamos los regímenes estacionales de precipitación de la fachada Mediterránea de la Península Ibérica empleando la base de datos de precipitaciones mensuales MOPREDAMES (1113 series mensuales; periodo 1951-2000). En cada observatorio se estimó el régimen de precipitación promedio y anualmente se calculó el régime...

Assessment of ethanol-fueled IMHEX{reg_sign} fuel cell power plants in distributed generation

Energy Technology Data Exchange (ETDEWEB)

Woods, R. [M-C Power Corp., Burr Ridge, IL (United States); Lefeld, J. [PSI Energy, Plainfield, IN (United States)

1993-12-31

Ethanol-fueled cell power plants presents several significant opportunities for the power generation industry. The potential exists to reduce pollution, help the nation shift from its dependence on imported fuels, reduce global warming, and strengthen the economy. Two important developments can be merged to create a clean, high-technology, bio-based energy system: the production of ethanol fuels and the application of fuel cell power plants. Utilization of ethanol will be in dual-fueled applications initially, and evolve toward the primary fuel as the need for renewable energy sources increase and the economic competitiveness improves. This assessment addresses the major issues of this proposed concept and outlines the benefits anticipated to the environment, US agriculture, energy supplies, and electric power customers. Economic and technical aspects of the concept are also reviewed. One of PSI Energy`s primary interests is the utilization of renewable fuels supplied by their customer base. The IMHEX{reg_sign} fuel cell is an advanced electric power generation technology currently under development by M-C Power. Commercial applications within the power generation industry are scheduled to begin during the late 1990s.

Exacerbation of spontaneous autoimmune nephritis following regulatory T cell depletion in B cell lymphoma 2-interacting mediator knock-out mice.

Science.gov (United States)

Wang, Y M; Zhang, G Y; Wang, Y; Hu, M; Zhou, J J; Sawyer, A; Cao, Q; Wang, Y; Zheng, G; Lee, V W S; Harris, D C H; Alexander, S I

2017-05-01

Regulatory T cells (T regs ) have been recognized as central mediators for maintaining peripheral tolerance and limiting autoimmune diseases. The loss of T regs or their function has been associated with exacerbation of autoimmune disease. However, the temporary loss of T regs in the chronic spontaneous disease model has not been investigated. In this study, we evaluated the role of T regs in a novel chronic spontaneous glomerulonephritis model of B cell lymphoma 2-interacting mediator (Bim) knock-out mice by transient depleting T regs . Bim is a pro-apoptotic member of the B cell lymphoma 2 (Bcl-2) family. Bim knock-out (Bim -/- ) mice fail to delete autoreactive T cells in thymus, leading to chronic spontaneous autoimmune kidney disease. We found that T reg depletion in Bim -/- mice exacerbated the kidney injury with increased proteinuria, impaired kidney function, weight loss and greater histological injury compared with wild-type mice. There was a significant increase in interstitial infiltrate of inflammatory cells, antibody deposition and tubular damage. Furthermore, the serum levels of cytokines interleukin (IL)-2, IL-4, IL-6, IL-10, IL-17α, interferon (IFN)-γ and tumour necrosis factor (TNF)-α were increased significantly after T reg depletion in Bim -/- mice. This study demonstrates that transient depletion of T regs leads to enhanced self-reactive T effector cell function followed by exacerbation of kidney disease in the chronic spontaneous kidney disease model of Bim-deficient mice. © 2017 British Society for Immunology.

In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

Directory of Open Access Journals (Sweden)

Che-Ming Liu

Full Text Available Cancer cells respond to stress by activating a variety of survival signaling pathways. A disintegrin and metalloproteinase (ADAM 9 is upregulated during cancer progression and hormone therapy, functioning in part through an increase in reactive oxygen species. Here, we present in vitro and in vivo evidence that therapeutic targeting of ADAM9 gene expression by lentivirus-delivered small hairpin RNA (shRNA significantly inhibited proliferation of human prostate cancer cell lines and blocked tumor growth in a murine model of prostate cancer bone metastasis. Cell cycle studies confirmed an increase in the G1-phase and decrease in the S-phase population of cancer cells under starvation stress conditions, which correlated with elevated intracellular superoxide levels. Microarray data showed significantly decreased levels of regenerating islet-derived family member 4 (REG4 expression in prostate cancer cells with knockdown of ADAM9 gene expression. This REG4 downregulation also resulted in induction of expression of p21(Cip1/WAF1, which negatively regulates cyclin D1 and blocks the G1/S transition. Our data reveal a novel molecular mechanism of ADAM9 in the regulation of prostate cancer cell proliferation, and suggests a combined modality of ADAM9 shRNA gene therapy and cytotoxic agents for hormone refractory and bone metastatic prostate cancer.

A rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals using a small HPLC Rocket[reg] column

Energy Technology Data Exchange (ETDEWEB)

Katsifis, Andrew [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)]. E-mail: akx@ansto.gov.au; Papazian, Vahan [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Jackson, Timothy [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia); Loc' h, Christian [Radiopharmaceuticals Division R and D, Australian Nuclear Science and Technology, Organisation, Menai, NSW 2234, Sydney (Australia)

2006-01-01

A simplified method for the rapid and efficient preparation of [{sup 123}I]radiopharmaceuticals is described. Three radiopharmaceuticals, [{sup 123}I]{beta}-CIT, [{sup 123}I]MIBG and [{sup 123}I]clioquinol, were synthesised and purified as model compounds. The radiotracers were labelled with iodine-123 using electrophilic oxidative conditions and purified by a compact semi-preparative reverse phase column (C-18, 3 {mu}m, 7x53 mm, Alltima Rocket[reg, Alltech] using aqueous-ethanol as HPLC solvents that were directly used for radiopharmaceutical formulation. The radiochemical purity of the radioiodinated tracers as assessed by analytical HPLC was higher than 99% with specific activity higher than 3 GBq/nmol. The total preparation time of a radiotracer ranged from 40 to 60 min and, starting from 3.7 GBq of iodine-123, more than 2.5 GBq of formulated radiopharmaceuticals were available for clinical investigations.

Linde Rectiscol{reg_sign} process. The most economic and experienced wash process for removal of sulfur compounds and CO{sub 2} from gasification gases

Energy Technology Data Exchange (ETDEWEB)

Kaballo, H.-P.; Kerestceciogly, U. [Linde AG, Hoellriegelskreuth (Germany). Linde Engineering Division

2006-07-01

The Recitsol{reg_sign} wash process is a well-proven process for the removal of H{sub 2}S/COS and CO{sub 2} from coal, asphalt, pitch or oil derived synthesis gas. It is a physical gas wash system using methanol as solvent at operating temperatures below water freezing point, to produce a synthesis gas with less than 0.1 vppm of total sulfur. The CO{sub 2} content can be adjusted in a range from several mol-percent down to a few ppm, as is required by the specified application. Its main advantages are the use of cheap and readily available methanol as solvent, the very flexible process configuration, and rather low utility consumption figures compared with other wash processes, like PEGE based process or chemical washes. A modern concept of a Rectisol{reg_sign} unit is described, to treat shifted and un-shifted gases in just one plant: shifted gas was used for hydrotreating in a refinery. Unshifted gas was used as fuel gas for power generation in an IGCC. CO{sub 2} of the unshifted feed gas was removed only partly, because the remaining CO{sub 2} was fed as inert gas together with the fuel gas to an IGCC. All sulfur compounds of both feed gases were concentrated in one single stream with a high H{sub 2}S concentration. Impurities like NH{sub 3}, HCN or metal carbonyls were eliminated nearly quantitatively. 4 refs., 4 figs., 3 tabs.

Radical, reformist and aborted liberalism: origins of national regimes in Central America Liberalismo radical, reformista y frustrado: orígenes de los regímenes nacionales en América central

Directory of Open Access Journals (Sweden)

James MAHONEY

2011-06-01

Full Text Available During the twentieth century, the countries of Central America were characterized by remarkably different political regimes: military-authoritarianism in Guatemala and El Salvador, progressive democracy in Costa Rica and traditional-authoritarianism in Honduras and Nicaragua. This article explains these contrasting regime outcomes by exploring the agrarian and state-building reforms pursued by political leaders during the nineteenth– and early twentieth century liberal reform period. Based on differences in the transformation of state and class structures, three types of liberalism are identified: radical liberalism in Guatemala and El Salvador, reformist liberalism in Costa Rica and aborted liberalism in Honduras and Nicaragua. It is argued that these types of liberalism set the Central American countries on contrasting paths of political development, culminating in diverse regime outcomes.Durante el siglo XX, los países de América Central se caracterizaron por tener regímenes políticos muy diferentes: el autoritarismo militar en Guatemala y El Salvador; la democracia progresista en Costa Rica y el autoritarismo tradicional en Honduras y Nicaragua. Este artículo explica los resultados de estos distintos regímenes mediante la exploración de las reformas agrarias y de la construcción del Estado llevadas a cabo por los líderes políticos durante el siglo XIX y principios del periodo de reformas liberales del siglo XX. Basándose en las diferencias de la transformación del Estado y de las estructuras de clases, se pueden identificar tres tipos de liberalismo: liberalismo radical en Guatemala y El Salvador; liberalismo reformista en Costa Rica y liberalismo frustrado en Honduras y Nicaragua. Se argumenta que estos tipos de liberalismo condujeron a los países de América Central a caminos contrarios al desarrollo político, culminando así en regímenes con resultados diversos.

Future Projections of Air Temperature and Precipitation for the CORDEX-MENA Domain by Using RegCM4.3.5

Science.gov (United States)

Ozturk, Tugba; Turp, M. Tufan; Türkeş, Murat; Kurnaz, M. Levent

2015-04-01

In this study, the projected changes for the periods of 2016 - 2035, 2046 - 2065, and 2081 - 2100 in the seasonal averages of air temperature and precipitation variables with respect to the reference period of 1981 - 2000 were examined for the Middle East and North Africa region. In this context, Regional Climate Model (RegCM4.3.5) of ICTP (International Centre for Theoretical Physics) was run by using two different global climate models. MPI-ESM-MR global climate model of the Max Planck Institute for Meteorology and HadGEM2 of the Met Office Hadley Centre were dynamically downscaled to 50 km for the CORDEX-MENA domain. The projections were realized according to the RCP4.5 and the RCP8.5 emission scenarios of the IPCC (Intergovernmental Panel of Climate Change).

Chemical and radiation stability of a proprietary cesium ion exchange material manufactured from WWL membrane and SuperLig reg-sign 644

International Nuclear Information System (INIS)

Brown, G.N.; Carson, K.J.; DesChane, J.R.; Elovich, R.J.; Berry, P.K.

1996-09-01

Pretreatment of nuclear process wastes for ion exchange removal of Cs and other radionuclides is one way to minimize amount of high-level radioactive waste at Hanford. This study evaluated Cs-selective SuperLig reg-sign 644 (IBC Advanced Technologies, American Fork UT) entrapped in a proprietary WWL web membrane (3M) for chemical/radiation stability in simulated caustic neutralized current acid waste (NCAW), 0.5M HNO 3 , water, and air. After exposure up to 2.0E+09 rad, the material was evaluated for Cs uptake in 5M sodium NCAW simulants with varying Cs contents. Radiolytic stability appears to be sufficient for ion exchange pretreatment of radioactive Cs: essentially no decrease in Cs selectivity or loading (Kd) was observed during 60 Cs gamma irradiation in water or 0.5M HNO 3 up to 1.0E+09 rad. Cs Kd decreased by a factor of 2 after 2.0E+09 rad exposure. Cs Kd did not change during irradiation in 5M NCAW or ambient air up to 1.0E+08 rad, but decreased by more than an order of magnitude between 1.0E+08 and 2.0E+09 rad (not typical of process conditions). Chemical stability under caustic conditions is lower than in air or under neutral/acidic conditions. Results indicate that this material is less stable in caustic solution irrespective of radiation exposure. Samples of the membrane retained their physical form throughout the entire experiment and were only slightly brittle after exposure to 2.0E+09 rad. (The material evaluated was a finely ground (400 mesh) particulate engineered to form a polymeric fiber (WWL), not the macroscopic form of SuperLig reg-sign 644 resin (20 to 50 mesh).)

A passive emergency heat sink for water cooled reactors with particular application to CANDU reg-sign reactors

International Nuclear Information System (INIS)

Spinks, N.J.

1996-01-01

Water in an overhead pool can serve as a general-purpose passive emergency heat sink for water-cooled reactors. It can be used for containment cooling, for emergency depressurization of the heat transport-system, or to receive any other emergency heat, such as that from the CANDU reg-sign moderator. The passive emergency water system provides in-containment depressurization of steam generators and no other provision is needed for supply of low-pressure emergency water to the steam generators. For containment cooling, the pool supplies water to the tube side of elevated tube banks inside containment. The elevation with respect to the reactor heat source maximizes heat transport, by natural convection, of hot containment gases. This effective heat transport combines with the large heat-transfer coefficients of tube banks, to reduce containment overpressure during accidents. Cooled air from the tube banks is directed past the break in the heat-transport system, to facilitate removal of hydrogen using passive catalytic recombiners

Changes in seasonal and diurnal precipitation types during summer over South Korea in the late twenty-first century (2081-2100) projected by the RegCM4.0 based on four RCP scenarios

Science.gov (United States)

Oh, Seok-Geun; Suh, Myoung-Seok

2018-01-01

Changes in seasonal and diurnal precipitation types over South Korea during summer in the late twenty-first century (2081-2100) were projected under four RCP scenarios using the Regional Climate Model (RegCM4.0) with a horizontal resolution of 12.5 km. Two boundary conditions, ERA-Interim and HadGEM2-AO, were used to drive the RegCM4.0 (jointly named RG4_ERA and RG4_HG2, respectively). In general, the RegCM4.0 reproduces the spatial distribution of summer precipitation over Northeast Asia for the current climate (1989-2008) reasonably well. The RG4_HG2 shows larger dry biases over South Korea, when compared with observations, than does the RG4_ERA. These strong dry biases result from the underestimation of convective precipitation (CPR) and are particularly noticeable in late afternoons during July and August. It is related to the performance of HadGEM2-AO which simulated southwesterly winds weakly in that time. However, interestingly, the RG4_HG2 simulates similar increases in the contribution of CPR to total precipitation after mid-July, resulting in comparable performance in the reproduction of heavy precipitation. In the late twenty-first century, a significant increase (decrease) in CPR (NCPR) is generally projected over South Korea, and particularly under the RCP8.5. During June, the total precipitation is affected primarily by changes in NCPR under RCP2.6 and RCP6.0. After mid-July, increasing total precipitation is primarily caused by the distinct increases in CPR in the late afternoons; this pattern is particularly noticeable under RCP8.5, which is associated with more destabilized atmospheric conditions during July and August. Light and heavy precipitation are projected to decrease and increase, respectively, under RCP8.5.

Impact of Dust on Air Quality and Radiative Forcing : AN Episodic Study for the Megacity Istanbul Using RegCM4.1

Science.gov (United States)

Agacayak, T.; Kindap, T.; Unal, A.; Mallet, M.; Pozzoli, L.; Karaca, M.; Solmon, F.

2012-04-01

Istanbul is a megacity (with population over 15 million) that has significant levels of Particulate Matter concentrations. It is suspected that long-range transport of Saharan dust is one of the main contributors. The purpose of this study is to investigate the relationship between high PM concentrations and dust transport using atmospheric modeling, satellite data as well as in-situ observations. Measurements of PM10 concentrations at 10 different stations in Istanbul for the period 2004-2010 were provided by the Turkish Ministry of Environment. Daily mean PM10 concentrations exceeding the European standard of 50 µg/m3 were found to be, on average, 49 days for the Spring period, 45 days for the Winter period, and 41 days for the Fall period. DREAM model output (Nickovic et al. 2001; Perez et al. 2006) suggests that high PM10 concentrations correlate highly with mineral dust transport episodes from Saharan desert (i.e., 23% for winter and 58% for spring). In this study, we have utilized RegCM4.1 model to further investigate the Saharan dust transport in the selected episodes. During the period between March 21st and 24th, 2008, observed daily mean of PM10 concentrations reach up to 140 µg/m3 in Istanbul. Simulations conducted by RegCM4.1 provides AOD (350-640 nm model band) values ranging between 0.04 and 0.98during this episode. Central Anatolia is affected from the dust transport on 21 and 22 March 2008, with a daily mean AOD of 0.9. On 23th March 2008, the dust plume reaches the Marmara Sea and AOD increases about 1.0 over the region according to both DREAM and RegCM4.1 model outputs. On the fourth day of the episode, the dust event stops and AOD decreases to 0.5 over the region. Asymmetry parameters can be seen as 0.62 during the dust episode, while single scattering albedo is about 0.93 during the entire dust episode over Istanbul. The effect of the dust episode on the regional radiative budget over Istanbul was also estimated. Model results indicate a daily

Analizando los regímenes de violación en la intersección entre la guerra y la paz en el Perú

OpenAIRE

Boesten, Jelke

2011-01-01

Utilizando el conflicto político en el Perú (1980-2000) como estudio de caso, en este trabajo sostengo que el hecho de entender la violación como arma de guerra oculta otros regímenes de violación que tuvieron lugar durante el conflicto armado interno y que no encajan necesariamente con esta definición.Estas prácticas incluyen la violación como consumo, la violación oportunista, la violación perpetrada por vecinos o miembros de la familia, la prostitución forzada y la violación en el periodo ...

Actinide extraction from ICPP sodium bearing waste with 0.75 M DHDECMP/TBP in Isopar L reg-sign

International Nuclear Information System (INIS)

Herbst, R.S.; Brewer, K.N.; Garn, T.G.; Law, J.D.; Rodriguez, A.M.; Tillotson, R.T.

1996-01-01

Recent process development efforts at the Idaho Chemical Processing Plant include examination of solvent extraction technologies for actinide partitioning from sodium bearing waste (SBW) solutions. The use of 0.75 M dihexyl-N, N-diethylcarbamoylmethylphosphonate (DHDECMP or simply CMP) and 1.0 M tri-n-butyl phosphate (TBP) diluted in Isopar L reg-sign was explored for actinide removal from simulated SBW solutions. Experimental evaluations included batch contacts in radiotracer tests with simulated sodium bearing waste solution to measure the extraction and recovery efficiency of the organic solvent. The radioactive isotopes utilized for this study included Pu-238, Pu-239, Am-241, U-233, Np-239, Zr-95, Tc-99m, and Hg-203. Extraction contacts of the organic solvent with the traced SBW stimulant, strip (back-extraction) contacts of the loaded organic solvent with either a 1-hydroxyethane-1, 1-diphosphonic acid (HEDPA) in nitric acid solution or an oxalic acid in nitric acid solution, and solvent wash contacts with sodium carbonate were performed

A regência dos verbos falar, sonhar, agradecer, pensar, colaborar e protestar do português e do francês sob a ótica da linguística contrastiva

OpenAIRE

Edson José Gomes

2004-01-01

A presente pesquisa contrasta a regência verbal do Português Língua Materna (PLM) e o ?complément d?object indirect (COI)? do Francês Língua Estrangeiro (FLE) a fim de identificar o tipo de transferência, negativa ou positiva, que a primeira exerce sob a segunda. Para tal, foram escolhidos os verbos ?falar?, ?sonhar?, ?agradecer?, ?pensar? ?colaborar? e ?protestar? (?parler?, ?rêver?, ?remercier?, ?penser?, ?collaborer? e ?protester?, respectivamente). A escolha dos verbos acima deveu-se por ...

Exposing the impact of opp(reg)ressive policies on teacher development and on student learning

Science.gov (United States)

Rodriguez, Alberto J.

2010-12-01

This case study draws attention to Pedro's story, a Grade 6 Latino teacher who, along with other grade 4-6 teachers, participated in a three-year professional development research project. By using data analyzed from multiple ethnographic interviews with teachers and students, and by drawing from the quantitative analyzes of concept map unit tests, we illustrate how Pedro's significant professional growth and his students' learning were truncated by top-down school district policies. These policies were implemented because of the punitive nature of the No Child Left Behind Act. Simply put, this case study exposes the impact of opp(reg)ressive policies on learning, that is, policies simultaneously oppressive and regressive. The critical perspective of the project, and its emphasis on assisting teachers to make their pedagogy and curriculum more culturally and socially relevant, was informed by sociotransformative constructivism (sTc). This is a theoretical framework that affords equal importance to cross-cultural education (learning about and acting on socially/culturally relevant issues) and social constructivism (learning to critically produce and consume knowledge). We hope that this case study will provide additional insights into the slow progress we continue to make in science teacher professional development and in closing the achievement gap.

Naturally occurring CD4+ CD25+ FOXP3+ T-regulatory cells are increased in chronic myeloid leukemia patients not in complete cytogenetic remission and can be immunosuppressive.

Science.gov (United States)

Rojas, Jose M; Wang, Lihui; Owen, Sally; Knight, Katy; Watmough, Sarah J; Clark, Richard E

2010-12-01

Clinical presentation of chronic myeloid leukemia (CML) requires not only the deregulated tyrosine kinase BCR-ABL, but also the failure of an immune response against BCR-ABL-expressing cells. T-cell responses against BCR-ABL and other antigens are well-described, but their relevance to the in vivo control of CML is unclear. The suppressive role of naturally occurring T regulatory (T-reg) cells in antitumor immunity is well-established, although little is known about their role in modulating the T-cell response to BCR-ABL. Naturally occurring T-reg cells were characterized and quantified by flow cytometry in 39 CML patients and 10 healthy donors. Their function was studied by observing their effect on responses to purified protein derivative, a recall antigen, and on the response of an autologous T-cell line recognizing BCR-ABL. T-reg cells were CD4(+), CD25(+), FOXP3(+), CD127(low), and CD62L(high). T-reg numbers in patients in complete cytogenetic remission were significantly lower than in patients not in complete cytogenetic remission (p T-reg cell depletion using anti-CD25 selection enhanced proliferative responses to purified protein derivative. Furthermore, the interferon-γ and/or granzyme-B production of effector cells specific for viral peptides or a BCR-ABL HLA-A3-restricted peptide was inhibited when autologous T-reg cells were present. Taken together, these data suggest a role for T-reg cells in limiting immune responses in CML patients and this may include immune responses to BCR-ABL. The increased frequency of T-reg cells in patients with high levels of BCR-ABL transcripts indicates that an immune mechanism may be important in the control of CML. Copyright © 2010 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

Aspectos comparativos da regência verbal em Português e Inglês para a elaboração de um dicionário bilíngue

OpenAIRE

Mendes, Raphael [UNESP

2013-01-01

Muitas vezes as gramáticas tradicionais e os dicionários existentes não são suficientes para resolver as dúvidas de estudantes e consulentes relativas a problemas linguísticos específicos. Com base nisso, propusemos um estudo de cunho contrastivo sobre uma temática pouco explorada, mas de grande relevância para a gramática e para a lexicografia: a regência verbal. Nos dicionários, esse tipo de informação gramatical é, em geral, tratado de forma imprecisa ou sequer aparece, o que pode dificult...

Mass Society

DEFF Research Database (Denmark)

Borch, Christian

2017-01-01

the negative features usually ascribed by late nineteenth-century crowd psychology to spontaneous crowds, and attributes these to the entire social fabric. However, in contrast to crowd psychology, theorists of mass society often place greater emphasis on how capitalism, technological advances, or demographic......Mass society is a societal diagnosis that emphasizes – usually in a pejorative, modernity critical manner – a series of traits allegedly associated with modern society, such as the leveling of individuality, moral decay, alienation, and isolation. As such, the notion of mass society generalizes...... developments condition such negative features, and some theorists argue that mass society produces a propensity to totalitarianism. Discussions of mass society culminated in the early and mid-twentieth century....

Digital Denmark: From Information Society to Network Society

DEFF Research Database (Denmark)

Henten, Anders; Falch, Morten

2000-01-01

for a welfare society. However, globalisation and the spreading use of new information and communication technologies and services challenge this position. This article examines Denmark's performance in implementing its IS 2000 plans, the background to the Digital Denmark report, and its implications......The Danish Government recently issued a new policy report, Digital Denmark, on the "conversion to a network society", as a successor to its Information Society 2000 report (1994). This is part of a new round of information society policy vision statements that are, or will be forthcoming from...... national governments everywhere. Denmark provides an interesting case study because it ranks high in the benchmark indicators of information network society developments. This position has been obtained largely by public sector initiatives and without erosion of the highly reputed Scandinavian model...

The Politics of Subnational Undemocratic Regime Reproduction in Argentina and Mexico La política de reproducción de los regímenes subnacionales no democráticos en Argentina y México

Directory of Open Access Journals (Sweden)

Agustina Giraudy

2010-01-01

Full Text Available This article studies the continued existence of subnational undemocraticregimes in Argentina and Mexico, two countries that have recently experiencednational democratization. The first part of the article offers a conceptualizationof subnational democracy and measures its territorial extension across all subnational units. The second part explores a common, albeit not systematically tested explanation about subnational undemocratic regime continuity, namely, that these regimes persist because they meet national incumbents’ strategic political needs. This claim is tested using statistical analyses to contrast patterns of spending across undemocratic subnational units during the presidencies of Menem (1989-1999, De la Rúa (2000-2001, Duhalde (2002, and Kirchner (2003-2007 in Argentina, and Fox (2000-2006 in Mexico. Contradicting conventional wisdom, the results show that presidents only reproduce a handful of subnational undemocratic regimes, as not all of them can meet presidential needs. In addition, the results reveal that the strategic calculation of presidents regarding this  reproduction is dictated by factors that have been largely overlooked by the literature. Este artículo estudia la existencia de regímenes subnacionales no-democráticos en Argentina y México, dos pa��ses que recientemente han experimentado procesos de democratización a nivel nacional. La primera parte del artículo conceptualiza y define la democracia subnacional y mide su extensión territorial en la totalidad de los distritos subnacionales. La segunda parte explora la validez de una de las explicaciones más habituales en esta área de estudio según la cual los regímenes subnacionales no-democráticos permanecen en el poder debido a que son útiles para satisfacer las necesidades políticas de los funcionarios nacionales. La validez de esta explicación se testea con análisis estadísticos que determinan los patrones de distribución territorial de

Bioabsorbable poly-L/D-lactide (96/4) scaffold arthroplasty (RegJoint™) for trapeziometacarpal osteoarthritis: a 3-year follow-up study.

Science.gov (United States)

Mattila, Simo; Ainola, Mari; Waris, Eero

2018-05-01

The poly-L/D-lactide joint scaffold (RegJoint™) has recently been associated with adverse tissue reactions and osteolysis after partial trapeziectomy for trapeziometacarpal osteoarthritis. Twenty-two of 23 patients previously operated on with this scaffold were re-examined at a mean follow-up of 3.3 years (range 36-53 months). Overall, the results showed an unacceptably high rate of adverse tissue reactions related to the degradation process of the implant, resulting in a revision procedure in three patients. At final follow-up, at which point the implant had completely degraded, there were no signs of ongoing adverse tissue reactions. There was a significant decrease in pain, increase in strength and subjective improvement in function at final follow-up compared with the pre-operative results in patients who had not undergone revision surgery. However, owing to the high incidence of adverse tissue reactions, the use of the implant has been discontinued in the treatment of trapeziometacarpal osteoarthritis. IV.

PowerGuard{reg_sign} Advanced Manufacturing; PVMaT Phase 1 Final Technical Report: June 1, 1998 to September 30, 1999

Energy Technology Data Exchange (ETDEWEB)

Marshall, M. C.; Dinwoodie, T. L.; O' Brian, C.; Botkin, J.; Ansley, J.

2000-06-14

During Phase 1 of PowerGuard{reg_sign} Advanced Manufacturing, PowerLight Corporation accomplished the following advancements: (1) Decreased system cost by 15%; (2) Increased PowerGuard tile production capacity from 5 MW/year to 8 MW/yr; (3) Established a manufacturing layout master plan for sequential integration of semi-automated and automated component workstations; (4) Defined semi-automation or automation of selected stages of the existing tile fabrication sequence, including PV module preparation, XPS processing, and coating; (5) Completed the advancement of several design improvements to the grid-tied inverter control board, including controller redesign, integrated data acquisition system (DAS), and communications for audit-worthy verification of PV system performance; (6) Conformed to NEPA, OSHA, and other federal and state regulations applicable to the proposed production process and mitigated potential for waste streams; (7) Initiated Underwriters Laboratories listings and international certifications on PowerGuard improvements; (8) Developed finance packages and integrated warranties; (9) Evaluated commercial demonstrations that incorporated the new design features and manufacturing process.

Regorafenib-induced hypothyroidism and cancer-related fatigue: is there a potential link?

Science.gov (United States)

Pani, Fabiana; Massidda, Matteo; Pusceddu, Valeria; Puzzoni, Marco; Massa, Elena; Madeddu, Clelia; Scartozzi, Mario; Mariotti, Stefano

2017-07-01

Thyroid dysfunction has been reported during Regorafenib (Reg) administration, but no detailed study is presently available. Prospective, observational cohort study. Patients with documented metastatic colorectal cancer and progression of disease during or within 3 months after the last standard therapy, with no evidence and history of previous thyroid disease were enrolled. Twenty-five consecutive patients were evaluated before and 8-50 weeks after initiating Reg therapy by monthly clinical, ultrasound and laboratory (thyrotropin (TSH), free thyroxine (fT4), antithyroglobulin (TgAb) and antithyroid peroxidase (TPOAb)) evaluation. Thirteen/25 patients (52%) became hypothyroid (TSH: 12.5 ± 4.01 IU/L, range: 4.6-22.0) within 5 months of therapy. TPOAb became detectable (99-155 IU/mL) in 2/25 (8%) patients. Thyroid volume progressively decreased (from 8.6  ±  2.2 mL to 4.9 ± 2.4 mL after 5 months of Reg therapy, P  hypothyroidism (43 weeks) than in those remaining euthyroid (17 weeks, P  hypothyroidism severity and reversed after levothyroxine therapy (L-T4). Reg rapidly causes hypothyroidism in about 50% of patients and in a minority of them also triggers thyroid autoimmunity. Reg-induced hypothyroidism was strictly related to fatigue, easily reversed by L-T4 administration and associated to longer survival. These results suggest that prompt recognition of hypothyroidism in patients with severe fatigue may prevent unnecessary Reg dose reduction or withdrawal. © 2017 European Society of Endocrinology.

Development of internal manifold heat exchanger (IMHEX reg sign ) molten carbonate fuel cell stacks

Energy Technology Data Exchange (ETDEWEB)

Marianowski, L.G.; Ong, E.T.; Petri, R.J.; Remick, R.J.

1991-01-01

The Institute of Gas Technology (IGT) has been in the forefront of molten carbonate fuel cell (MCFC) development for over 25 years. Numerous cell designs have been tested and extensive tests have been performed on a variety of gas manifolding alternatives for cells and stacks. Based upon the results of these performance tests, IGT's development efforts started focusing on an internal gas manifolding concept. This work, initiated in 1988, is known today as the IMHEX{reg sign} concept. MCP has developed a comprehensive commercialization program loading to the sale of commercial units in 1996. MCP's role is in the manufacture of stack components, stack assembly, MCFC subsystem testing, and the design, marketing and construction of MCFC power plants. Numerous subscale (1 ft{sup 2}) stacks have been operated containing between 3 and 70 cells. These tests verified and demonstrated the viability of internal manifolding from technical (no carbonate pumping), engineering (relaxed part dimensional tolerance requirements), and operational (good gas sealing) aspects. Simplified fabrication, ease of assembly, the elimination of external manifolds and all associated clamping requirements has significantly lowered anticipated stack costs. Ongoing 1 ft{sup 2} stack testing is generating performance and endurance characteristics as a function of system specified operating conditions. Commercial-sized, full-area stacks (10 ft{sup 2}) are in the process of being assembled and will be tested in November. This paper will review the recent developments the MCFC scale-up and manufacture work of MCP, and the research and development efforts of IGT which support those efforts. 17 figs.

Development of internal manifold heat exchanger (IMHEX reg-sign) molten carbonate fuel cell stacks

International Nuclear Information System (INIS)

Marianowski, L.G.; Ong, E.T.; Petri, R.J.; Remick, R.J.

1991-01-01

The Institute of Gas Technology (IGT) has been in the forefront of molten carbonate fuel cell (MCFC) development for over 25 years. Numerous cell designs have been tested and extensive tests have been performed on a variety of gas manifolding alternatives for cells and stacks. Based upon the results of these performance tests, IGT's development efforts started focusing on an internal gas manifolding concept. This work, initiated in 1988, is known today as the IMHEX reg-sign concept. MCP has developed a comprehensive commercialization program loading to the sale of commercial units in 1996. MCP's role is in the manufacture of stack components, stack assembly, MCFC subsystem testing, and the design, marketing and construction of MCFC power plants. Numerous subscale (1 ft 2 ) stacks have been operated containing between 3 and 70 cells. These tests verified and demonstrated the viability of internal manifolding from technical (no carbonate pumping), engineering (relaxed part dimensional tolerance requirements), and operational (good gas sealing) aspects. Simplified fabrication, ease of assembly, the elimination of external manifolds and all associated clamping requirements has significantly lowered anticipated stack costs. Ongoing 1 ft 2 stack testing is generating performance and endurance characteristics as a function of system specified operating conditions. Commercial-sized, full-area stacks (10 ft 2 ) are in the process of being assembled and will be tested in November. This paper will review the recent developments the MCFC scale-up and manufacture work of MCP, and the research and development efforts of IGT which support those efforts. 17 figs

Effects of climate changes on dust aerosol over East Asia from RegCM3

Directory of Open Access Journals (Sweden)

Dong-Feng Zhang

2016-09-01

Full Text Available In order to understand impacts of global warming on dust aerosol over East Asia, a regional climate model (RegCM3 coupled with a dust model is employed to simulate the present (1991–2000, following the observed concentration of the greenhouse gases and future (2091–2100, following the A1B scenario dust aerosol. Three experiments are performed over East Asia at a horizontal resolution of 50 km, driven by the outputs from a global model of the Model for Interdisciplinary Research on Climate (MIROC3.2_hires, two without (Exp.1 for the present and Exp.2 for the future and one with (Exp.3 for the future the radiative effects of dust aerosols. Effects of climate changes on dust aerosols and the feedback of radiative effects in the future are investigated by comparing differences of Exp.2 and Exp.1, Exp.3 and Exp.2, respectively. Results show that global warming will lead to the increases of dust emissions and column burden by 2% and 14% over East Asia, characterized by the increase in December–January–February–March (DJFM and the decrease in April–May (AM. Similar variations are also seen in the projected frequencies of high dust emission events, showing an advanced active season of dust in the future. The net top-of-atmosphere (TOA radiative forcing is positive over the desert source regions and negative over downwind regions, while the surface radiative forcing is negative over the domain, which will lead to a reduction of dust emissions and column burden.

Association between discordant immunological response to highly active anti-retroviral therapy, regulatory T cell percentage, immune cell activation and very low-level viraemia in HIV-infected patients.

Science.gov (United States)

Saison, J; Ferry, T; Demaret, J; Maucort Boulch, D; Venet, F; Perpoint, T; Ader, F; Icard, V; Chidiac, C; Monneret, G

2014-06-01

The mechanisms sustaining the absence of complete immune recovery in HIV-infected patients upon long-term effective highly active anti-retroviral therapy (HAART) remain elusive. Immune activation, regulatory T cells (T(regs)) or very low-level viraemia (VLLV) have been alternatively suspected, but rarely investigated simultaneously. We performed a cross-sectional study in HIV-infected aviraemic subjects (mean duration of HAART: 12 years) to concomitantly assess parameters associated independently with inadequate immunological response. Patients were classified as complete immunological responders (cIR, n = 48) and inadequate immunological responders (iIR, n = 39), depending on the CD4(+) T cell count (> or response to long-term HAART, activation of CD4(+) and CD8(+) T cells, T(reg) percentages and very low-level viraemia. Causative interactions between T(regs) and CD4(+) T cells should now be explored prospectively in a large patients cohort. © 2014 British Society for Immunology.

Planetary Society

Science.gov (United States)

Murdin, P.

2000-11-01

Carl Sagan, Bruce Murray and Louis Friedman founded the non-profit Planetary Society in 1979 to advance the exploration of the solar system and to continue the search for extraterrestrial life. The Society has its headquarters in Pasadena, California, but is international in scope, with 100 000 members worldwide, making it the largest space interest group in the world. The Society funds a var...

Society Catalog Information - Society Catalog | LSDB Archive [Life Science Database Archive metadata

Lifescience Database Archive (English)

Full Text Available n DOI 10.18908/lsdba.nbdc00963-001 Description of data contents Information of the academic societies in Jap...tion URL Website URL for the society Name Society name Abbreviation Abbreviation for the societ...y name Class Classification for the society Membership fee Membership fee Academy remarks Acad...me for the academic journal published by the society Academic journal: Language of text Language of text for

The Information Society

Directory of Open Access Journals (Sweden)

Hiranya Nath

2017-03-01

Full Text Available This article briefly discusses various definitions and concepts of the so-called information society. The term information society has been proposed to refer to the post-industrial society in which information plays a pivotal role. The definitions that have been proposed over the years highlight five underlying characterisations of an information society: technological, economic, sociological, spatial, and cultural. This article discusses those characteristics. While the emergence of an information society may be just a figment of one’s imagination, the concept could be a good organising principle to describe and analyse the changes of the past 50 years and of the future in the 21st century.

Autism Society

Science.gov (United States)

... Español Improving the lives of all affected by autism. The Autism Society is the nation's leading grassroots ... more Improving the lives of all affected by autism. The Autism Society is the nation's leading grassroots ...

Citizenship in civil society?

NARCIS (Netherlands)

Ossewaarde, Marinus R.R.

2007-01-01

This article seeks to provide a conceptual framework to complement and guide the empirical analysis of civil society. The core argument is that civil society must be understood, not as a category of (post)industrialized society, but as one of individualized society. Civil society is characterized by

Reclaiming Society Publishing

Directory of Open Access Journals (Sweden)

Philip E. Steinberg

2015-07-01

Full Text Available Learned societies have become aligned with commercial publishers, who have increasingly taken over the latter’s function as independent providers of scholarly information. Using the example of geographical societies, the advantages and disadvantages of this trend are examined. It is argued that in an era of digital publication, learned societies can offer leadership with a new model of open access that can guarantee high quality scholarly material whose publication costs are supported by society membership dues.

Indian Vacuum Society: The Indian Vacuum Society

Science.gov (United States)

Saha, T. K.

2008-03-01

The Indian Vacuum Society (IVS) was established in 1970. It has over 800 members including many from Industry and R & D Institutions spread throughout India. The society has an active chapter at Kolkata. The society was formed with the main aim to promote, encourage and develop the growth of Vacuum Science, Techniques and Applications in India. In order to achieve this aim it has conducted a number of short term courses at graduate and technician levels on vacuum science and technology on topics ranging from low vacuum to ultrahigh vacuum So far it has conducted 39 such courses at different parts of the country and imparted training to more than 1200 persons in the field. Some of these courses were in-plant training courses conducted on the premises of the establishment and designed to take care of the special needs of the establishment. IVS also regularly conducts national and international seminars and symposia on vacuum science and technology with special emphasis on some theme related to applications of vacuum. A large number of delegates from all over India take part in the deliberations of such seminars and symposia and present their work. IVS also arranges technical visits to different industries and research institutes. The society also helped in the UNESCO sponsored post-graduate level courses in vacuum science, technology and applications conducted by Mumbai University. The society has also designed a certificate and diploma course for graduate level students studying vacuum science and technology and has submitted a syllabus to the academic council of the University of Mumbai for their approval, we hope that some colleges affiliated to the university will start this course from the coming academic year. IVS extended its support in standardizing many of the vacuum instruments and played a vital role in helping to set up a Regional Testing Centre along with BARC. As part of the development of vacuum education, the society arranges the participation of

Information exchange of the Atomic Energy Society of Japan with nuclear societies worldwide

International Nuclear Information System (INIS)

Hori, Masao; Tomita, Yasushi

2000-01-01

The Atomic Energy Society of Japan (AESJ) exchanges information with nuclear societies worldwide by intersocietal communication through international councils of nuclear societies and through bilateral agreements between foreign societies and by such media as international meetings, publications, and Internet applications

Transforming Society

DEFF Research Database (Denmark)

Enemark, Stig; Dahl Højgaard, Pia

2017-01-01

, was a result of transforming society from a feudal system to a capitalistic and market based economy. This story is interesting in itself - but it also provides a key to understanding the cadastral system of today. The system has evolved over time and now serves a whole range of functions in society. The paper...

Main Dynamics of the Transition from Industrial Society to Information Society

Directory of Open Access Journals (Sweden)

Yaşar Tonta

2005-12-01

Full Text Available Industrial Society is based on mass production and mass distribution of standardized goods and services. The objective of companies is to reduce the unit cost by producing and distributing the same goods in large quantities cheaper than their competitors. Mass production and mass distribution requires an economic model based on centralization; mechanistical, rigid/hierarchical organizational structures; and traditional education. Companies act on the basis of the logic of “produce, store, and sell”. Information Society on the other hand is an indication of a more complex and richer social structure. The objective of companies is to produce mass customized and personalized goods and services for their customers. The customer can buy a personalized good or service with the best price from anywhere in the world. Called “The Age of Terrific Deal” by Robert B. Reich, Information Society requires an economic model based on personalization; dynamic and flat organizational structures; and customer focused education. Companies must act on the basis of the logic of “sell, produce, and deliver”. This paper discusses the major changes that take place during the transition from Industrial Society to Information Society along with basic dynamics of the Information Society.

The National Cardiac Societies of the European Society of Cardiology.

Science.gov (United States)

Atar, Dan

2015-06-01

The National Cardiac Societies are one of the Constituent Bodies of the European Society of Cardiology (ESC). They are the backbone of the ESC and together form the "Cardiology of Europe" in 56 European and Mediterranean countries.

The performance of RegCM4 over the Central America and Caribbean region using different cumulus parameterizations

Science.gov (United States)

Martínez-Castro, Daniel; Vichot-Llano, Alejandro; Bezanilla-Morlot, Arnoldo; Centella-Artola, Abel; Campbell, Jayaka; Giorgi, Filippo; Viloria-Holguin, Cecilia C.

2018-06-01

A sensitivity study of the performance of the RegCM4 regional climate model driven by the ERA Interim reanalysis is conducted for the Central America and Caribbean region. A set of numerical experiments are completed using four configurations of the model, with a horizontal grid spacing of 25 km for a period of 6 years (1998-2003), using three of the convective parameterization schemes implemented in the model, the Emanuel scheme, the Grell over land-Emanuel over ocean scheme and two configurations of the Tiedtke scheme. The objective of the study is to investigate the ability of each configuration to reproduce different characteristics of the temperature, circulation and precipitation fields for the dry and rainy seasons. All schemes simulate the general temperature and precipitation patterns over land reasonably well, with relatively high correlations compared to observation datasets, though in specific regions there are positive or negative biases, greater in the rainy season. We also focus on some circulation features relevant for the region, such as the Caribbean low level jet and sea breeze circulations over islands, which are simulated by the model with varied performance across the different configurations. We find that no model configuration assessed is best performing for all the analysis criteria selected, but the Tiedtke configurations, which include the capability of tuning in particular the exchanges between cloud and environment air, provide the most balanced range of biases across variables, with no outstanding systematic bias emerging.

A PC Program to Calculate the One-Sided Lower Tolerance Limit for Total Ionizing Dose Radiation Data

Science.gov (United States)

1991-08-01

include <graphics .h> #define VEDIO OxlO #define ESC 27 1* Decelerations * FILE *pfile; FILE *outf; FILE *inf; mnt n; mnt un; float max scale...regs.h.ah=2; regs .h.dh=y; regs .h.dl=x; regs .h.bh=O; int86( VEDIO , &regs, &regs); char attribute(char blink, char back-color,char intensity, char...set lint mode) union REGS regs; regs.h.ah=O; regs h a l-mode; int86( VEDIO , &regs, &regs); void str-color (char x, char y, char *str, char blink, char

FZUImageReg: A toolbox for medical image registration and dose fusion in cervical cancer radiotherapy.

Directory of Open Access Journals (Sweden)

Qinquan Gao

Full Text Available The combination external-beam radiotherapy and high-dose-rate brachytherapy is a standard form of treatment for patients with locally advanced uterine cervical cancer. Personalized radiotherapy in cervical cancer requires efficient and accurate dose planning and assessment across these types of treatment. To achieve radiation dose assessment, accurate mapping of the dose distribution from HDR-BT onto EBRT is extremely important. However, few systems can achieve robust dose fusion and determine the accumulated dose distribution during the entire course of treatment. We have therefore developed a toolbox (FZUImageReg, which is a user-friendly dose fusion system based on hybrid image registration for radiation dose assessment in cervical cancer radiotherapy. The main part of the software consists of a collection of medical image registration algorithms and a modular design with a user-friendly interface, which allows users to quickly configure, test, monitor, and compare different registration methods for a specific application. Owing to the large deformation, the direct application of conventional state-of-the-art image registration methods is not sufficient for the accurate alignment of EBRT and HDR-BT images. To solve this problem, a multi-phase non-rigid registration method using local landmark-based free-form deformation is proposed for locally large deformation between EBRT and HDR-BT images, followed by intensity-based free-form deformation. With the transformation, the software also provides a dose mapping function according to the deformation field. The total dose distribution during the entire course of treatment can then be presented. Experimental results clearly show that the proposed system can achieve accurate registration between EBRT and HDR-BT images and provide radiation dose warping and fusion results for dose assessment in cervical cancer radiotherapy in terms of high accuracy and efficiency.

The Society for Scandinavian Art

DEFF Research Database (Denmark)

Grand, Karina Lykke

2016-01-01

The Society for Nordic Art & the Scandinavian Society [Selskabet for Nordisk Kunst & Skandinavisk Selskab]......The Society for Nordic Art & the Scandinavian Society [Selskabet for Nordisk Kunst & Skandinavisk Selskab]...

Consumption in the Information Society

Science.gov (United States)

Zherebin, V. M.; Ermakova, N. A.; Makhrova, O. N.

2010-01-01

The current state of the economy in the developed countries make it possible to characterize them using concepts and terms such as the postindustrial society, the new economy, the service economy, the creative economy, the posteconomic society, the information society, the knowledge society, and the consumer society. Among these terms and…

Society-ethics-risk

International Nuclear Information System (INIS)

Ruh, H.; Seiler, H.

1993-01-01

The aim of the workshops which was reported in this volume, was the interpretation and evaluation of catastrophic risks for society in an interdisciplinary dialogue between representation of society, ethics, as well as natural science and technology. (author) figs., tabs., refs

New light on R.E.G. Pichi Sermolli’s plants from the Lake Tana expedition in 1937 – an important collection from Ethiopia at the Centro Studi Erbario Tropicale (FT)

DEFF Research Database (Denmark)

Friis, Ib

2015-01-01

At the age of 24, R.E.G. Pichi Sermolli (1912–2005) travelled to Ethiopia as botanist on the Missione di Studio al Lago Tana, staying in Eritrea and Ethiopia from early January to late April 1937. The expedition was organized by the Centro Studi per l’Africa Orientale Italiana under the Reale...... Accademia d’Italia and resulted in 2649 collections of flowering plants. During the subsequent years of war, Pichi Sermolli had no time for his Ethiopian collections, but in 1947 he was able to identify them on visits to Geneva, Paris, Kew and London. Erbario Tropicale (FT) received the first set...

Information society studies

CERN Document Server

Duff, Alistair S

2013-01-01

We are often told that we are ""living in an information society"" or that we are ""information workers."" But what exactly do these claims mean, and how might they be verified? In this important methodological study, Alistair S. Duff cuts through the rhetoric to get to the bottom of the ""information society thesis."" Wide-ranging in coverage, this study will be of interest to scholars in information science, communication and media studies and social theory. It is a key text for the newly-unified specialism of information society studies, and an indispensable guide to the future of this disc

Nuclear power and modern society

International Nuclear Information System (INIS)

Komarek, A.

1999-01-01

A treatise consisting of the following sections: Development of modern society (Origin of modern society; Industrial society; The year 1968; Post-industrial society; Worldwide civic society); Historic breaks in the development of the stationary power sector (Stationary thermal power; Historic breaks in the development of nuclear power); Czech nuclear power engineering in the globalization era (Major causes of success of Czech nuclear power engineering; Future of Czech nuclear power engineering). (P.A.)

Mexican Society of Bioelectromagnetism

International Nuclear Information System (INIS)

Canedo, Luis

2008-01-01

In July 2007 physicians, biologists and physicists that have collaborated in previous meetings of the medical branch of the Mexican Physical Society constituted the Mexican Society of Bioelectromagnetism with the purpose of promote scientific study of the interaction of electromagnetic energy (at frequencies ranging from zero Hertz through those of visible light) and acoustic energy with biological systems. A second goal was to increase the contribution of medical and biological professionals in the meetings of the medical branch of the Mexican Physical Society. The following paragraphs summarize some objectives of the Mexican Society of Bioelectromagnetism for the next two years

Participation of women in neurochemistry societies.

Science.gov (United States)

Lees, Marjorie B

2002-11-01

Women have made important scientific contributions to the field of neurochemistry, and they have also been leaders in neurochemical societies throughout the world. Here I discuss women's involvement and leadership in six neurochemistry societies: American Society for Neurochemistry, Argentine Society for Neurochemistry, International Society for Neurochemistry, European Society for Neurochemistry, Japanese Society for Neurochemistry, and Asian-Pacific Society for Neurochemistry. The number of women who have been active in these societies and the level of their activity vary considerably. Neurochemical societies in the Western hemisphere, i.e., the American and the Argentine Society for Neurochemistry, have much greater numbers of women who have held office, been on council, or engaged in other leadership activities than in the rest of the world. The limited participation of women in the Japanese Neurochemistry Society relates to Japanese cultural views and was not unexpected. However, the relatively few women leaders in the International Society for Neurochemistry was a surprise. The European Society had a somewhat better record of female participation than did the International Society. The reasons for these differences are partly cultural, but factors related to when each society was formed, how it is organized, and how elections are structured undoubtedly play a role. Further analysis of these observations would be of interest from a sociological and a women's studies point of view.

Nuclear technology and society

International Nuclear Information System (INIS)

Suzuki, Tatsujiro; Tanaka, Yutaka; Taniguchi, Taketoshi; Oyama, Kosuke

1999-01-01

This special issue of Journal of the Atomic Energy Society of Japan deals with the relation between nuclear technology and society, and is composed of four papers: (1) Nuclear energy and international politics - sociotechnics around plutonium utilization; (2) Risk recognition and benefit recognition of nuclear facilities and social acceptance; (3) Environmental risk management and radioactive waste problem; and, (4) Public administration around the relation between nuclear energy and society. (1) describes the historical development of nuclear energy since its birth, focusing on how the leading countries tried to control nuclear proliferation. Peaceful utilization of nuclear energy is closely connected with the Non-proliferation problem. (1) also discusses the relation of plutonium utilization of Japan with international society. (2) discusses how nuclear facilities can be accepted by society, analyzing the background of risk recognition, in particular, of psychological character of mass society. (3) introduces an new approach (risk-based or risk-informed regulation) of environmental risk management for radioactive waste disposal problem, focusing on HLW (high-level waste). (4) explains the approach from public administration to nuclear energy and general energy policy and introduces PPA (participatory policy analysis) as a means for policy making. (M.M.)

CERN & Society launches donation portal

CERN Multimedia

Cian O'Luanaigh

2014-01-01

The CERN & Society programme brings together projects in the areas of education and outreach, innovation and knowledge exchange, and culture and arts, that spread the CERN spirit of scientific curiosity for the inspiration and benefit of society. Today, CERN & Society is launching its "giving" website – a portal to allow donors to contribute to various projects and forge new relationships with CERN.   "The CERN & Society initiative in its embryonic form began almost three years ago, with the feeling that the laboratory could play a bigger role for the benefit of society," says Matteo Castoldi, Head of the CERN Development Office, who, with his team, is seeking supporters and ambassadors for the CERN & Society initiative. "The concept is not completely new – in some sense it is embedded in CERN’s DNA, as the laboratory helps society by creating knowledge and new technologies – but we would like to d...

Exploratory of society

Science.gov (United States)

Cederman, L.-E.; Conte, R.; Helbing, D.; Nowak, A.; Schweitzer, F.; Vespignani, A.

2012-11-01

A huge flow of quantitative social, demographic and behavioral data is becoming available that traces the activities and interactions of individuals, social patterns, transportation infrastructures and travel fluxes. This has caused, together with innovative computational techniques and methods for modeling social actions in hybrid (natural and artificial) societies, a qualitative change in the ways we model socio-technical systems. For the first time, society can be studied in a comprehensive fashion that addresses social and behavioral complexity. In other words we are in the position to envision the development of large data and computational cyber infrastructure defining an exploratory of society that provides quantitative anticipatory, explanatory and scenario analysis capabilities ranging from emerging infectious disease to conflict and crime surges. The goal of the exploratory of society is to provide the basic infrastructure embedding the framework of tools and knowledge needed for the design of forecast/anticipatory/crisis management approaches to socio technical systems, supporting future decision making procedures by accelerating the scientific cycle that goes from data generation to predictions.

Religion, civil society and conflict: What is it that religion does for and to society?

Directory of Open Access Journals (Sweden)

Jaco Beyers

2011-08-01

Full Text Available Human consciousness instinctively tries to make sense of reality. Different human interpretations of reality lead to a world consisting of multiple realities. Conflict occurs when differing realities (worldviews encounter one another. Worldviews are socially created and determine human behaviour and, as such, most often find expression in religion. The discussion of conflict and the role of religion in civil society take place within the discourse of the sociology of religion. Religion is socially determined. Peter Berger’s insight into the sociology of religion therefore plays an important role in establishing the relationship between religion and civil society as one that takes on different forms. Thus, a clear definition of both civil society and religion was needed to understand the nature of these relationships. The role of religion in civil society with regard to the presence of conflict in society was further investigated in this article. The conditions under which conflict in society occurs were discussed, as were the conditions for tolerance in society, for religion ultimately becomes the provider of moral discernment when conflict occurs in civil society.

Civil society sphericules

DEFF Research Database (Denmark)

Tufte, Thomas

2014-01-01

the organization strategizes about and seeks to articulate amongst Tanzanian youth. Situated in the ‘perverse confluence’ (Dagnino, 2011) between neoliberal and radical democratic agendas in the communicative practices of civil society-driven media platforms, Femina navigates between identities as an NGO, a social...... movement and a media initiative. In the context of the growing literature on social networking sites and their affordances, dynamics and structures, the case of Femina illustrates how a civil society sphericule emerges within the dynamic co-evolution of new and old media platforms. The study is furthermore...... an example of the difficult shift in civil society practice, from service provision to an agenda of public service monitoring, social accountability and community engagement....

Society and education

DEFF Research Database (Denmark)

Moutsios, Stavros

in Europe. Elaborating on the Castoriadian ontology, the book delves into the magma of social imaginary significations that characterise and associate pivotal epochs of the continent’s history, Classical Greece and Modernity, and exemplifies their incarnation in educational systems and in the formation...... countries. Nevertheless, as Moutsios suggests, the European tradition, notwithstanding its ideological usage by much of social sciences, contains an indissoluble critical and self-reflective dimension, which needs to be sustained and advanced in education and its cross-cultural comparison, perhaps, more......'Society and Education: An Outline of Comparison' explores the relation of society to education in Europe, as well as its comparative perspective towards overseas societies and their institutions. It is an enquiry into the social-historical institution of education and cross-cultural studies...

Important considerations for radiochromic film dosimetry with flatbed CCD scanners and EBT GAFCHROMIC[reg] film

International Nuclear Information System (INIS)

Lynch, Bart D.; Kozelka, Jakub; Ranade, Manisha K.; Li, Jonathan G.; Simon, William E.; Dempsey, James F.

2006-01-01

In this study, we present three significant artifacts that have the potential to negatively impact the accuracy and precision of film dosimetry measurements made using GAFCHROMIC[reg] EBT radiochromic film when read out with CCD flatbed scanners. Films were scanned using three commonly employed instruments: a Macbeth TD932 spot densitometer, an Epson Expression 1680 CCD array scanner, and a Microtek ScanMaker i900 CCD array scanner. For the two scanners we assessed the variation in optical density (OD) of GAFCHROMIC EBT film with scanning bed position, angular rotation of the film with respect to the scan line direction, and temperature inside the scanner due to repeated scanning. Scanning uniform radiochromic films demonstrated a distinct bowing effect in profiles in the direction of the CCD array with a nonuniformity of up to 17%. Profiles along a direction orthogonal to the CCD array demonstrated a 7% variation. A strong angular dependence was found in measurements made with the flatbed scanners; the effect could not be reproduced with the spot densitometer. An IMRT quality assurance film was scanned twice rotating the film 90 deg. between the scans. For films scanned on the Epson scanner, up to 12% variation was observed in unirradiated EBT films rotated between 0 deg. and 90 deg. , which decreased to approximately 8% for EBT films irradiated to 300 cGy. Variations of up to 80% were observed for films scanned with the Microtek scanner. The scanners were found to significantly increase the film temperature with repeated scanning. Film temperature between 18 and 33 deg. C caused OD changes of approximately 7%. Considering these effects, we recommend adherence to a strict scanning protocol that includes: maintaining the orientation of films scanned on flatbed scanners, limiting scanning to the central portion of the scanner bed, and limiting the number of consecutive scans to minimize changes in OD caused by film heating

Seasonal prediction for Southern Africa: Maximising the skill from forecast systems

CSIR Research Space (South Africa)

Landman, WA

2012-06-01

Full Text Available /system development started in early 1990s ? SAWS, UCT, UP, Wits (statistical forecast systems) ? South African Long-Lead Forecast Forum ? SARCOF started in 1997 ? consensus through discussions ? Late 1990s ? started to use AGCMs and post-processing ? At SAWS... Reg1 Reg2 Reg3 Reg4 Reg5 Reg6 Reg7 Reg8 Regions RO C ar ea s Below-Normal Near-Normal Above-Normal Operational Forecast Skill From CONSENSUS discussions Verification over 7 years of consensus forecast production New objective multi...

Information Exchange of the Atomic Energy Society of Japan with Nuclear Societies Worldwide

International Nuclear Information System (INIS)

Masao Hori; Yasushi Tomita

2000-01-01

This paper describes committees of the Atomic Energy Society of Japan (AESJ) related to information exchange, AESJ publications, AESJ Internet applications, and means for future information exchange between nuclear societies

Civil Society and Governance

DEFF Research Database (Denmark)

Hulgård, Lars

An illustration of how important the relationship is between civil society anbd governance. A short historic journey with four snapshots of times and situations that have provided interesting evidence about the connection between civil society and governance. My goal for the short historic journey...... is to make clear and hopefully even verify that providing knowledge about the impact of civil society and citizens’ participation on governance is one of the most urgent research tasks in the current period of time....

Indicators of Information Society Measurement :

Directory of Open Access Journals (Sweden)

Hind Elwy

2006-09-01

Full Text Available The indicator of information society describe the infrastructure of information and communication technology ; as well as it’s use and it’s production in different estate of society. The importance economic and social of tic is crescent in modern society. and the presentation of tendency inform above the situation of information society . in this article we want to describe the indicator of tic in Algeria according to librarian’s vision in Mentouri university

Regadenoson pharmacologic stress for myocardial perfusion imaging: a three-way comparison between regadenoson administered at peak exercise, during walk recovery, or no-exercise.

Science.gov (United States)

Thompson, Randall C; Patil, Harshal; Thompson, Elaine C; Thomas, Gregory S; Al-Amoodi, Mohammed; Kennedy, Kevin F; Bybee, Kevin A; Iain McGhie, A; O'Keefe, James H; Oakes, Lisa; Bateman, Timothy M

2013-04-01

Regadenoson (Reg) is being administered with increasing frequency either at peak exercise (ExPeak-Reg) or during a slow-down/walking recovery state (ExRec-Reg) rather than at rest (Rest-Reg). The aim of this study was to compare the clinical response of ExPeak-Reg, ExRec-Reg, and Rest-Reg. We compared 531 patients divided equally between Rest-Reg, ExPeak-Reg, and ExRec-Reg matched for age, sex, and BMI. The average systolic blood pressure (SBP) rise following Reg was modest, but there was considerable heterogeneity and the ExPeak-Reg group had a higher percentage of patients who had a SBP rise of 40 mm Hg or a fall of 20 mm Hg than either the ExRec-Reg or the Rest-Reg groups (≥40 mm Hg rise 6.8%, 1.7%, and 1.7%, respectively) (P < .02) (≥20 mm Hg fall 15.8%, 13.0%, and 7.3%, respectively) (P < .05). Chest discomfort, nausea, dizziness, and interfering abdominal radiotracer activity were less common in both exercise Reg groups compared to Rest-Reg (P < .05). Regadenoson injected at peak of symptom-limited exercise was generally well tolerated, but some patients had a significant rise or drop in SBP. There is no apparent advantage of administering regadenoson at peak exercise rather than during walk recovery, and the latter approach may have a greater safety margin.

The Society for Translational Medicine

DEFF Research Database (Denmark)

Gao, Shugeng; Zhang, Zhongheng; Aragón, Javier

2017-01-01

The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy. Recommendati......The Society for Translational Medicine and The Chinese Society for Thoracic and Cardiovascular Surgery conducted a systematic review of the literature in an attempt to improve our understanding in the postoperative management of chest tubes of patients undergoing pulmonary lobectomy...

American Society of Echocardiography

Science.gov (United States)

American Society of Echocardiography Join Ase Renew Member Portal Log In Membership Member Portal Log In Join ASE Renew Benefits Rates FASE – Fellow of the American Society of Echocardiography Member Referral Program FAQs Initiatives Advocacy Awards, Grants, ...

Climate and Ancient Societies

DEFF Research Database (Denmark)

Climate, and human responses to it, have a strongly interconnected relationship. This when climate change occurs, the result of either natural or human causes, societies should react and adapt to these. But do they? If so, what is the nature of that change, and are the responses positive...... or negative for the long-term survival of social groups? In this volume, scholars from diverse disciplines including archaeology, geology and climate sciences explore scientific and material evidence for climate changes in the past, their causes, their effects on ancient societies and how those societies...

Did Educational Expansion Trigger the Development of an Education Society? Chances and Risks of a New Model of Society

Science.gov (United States)

Haunberger, Sigrid

2010-01-01

This article focuses on the question of whether educational expansion leads to a new type of society, the education society. Taking into consideration the combined elements of three models of society (the post-industrial society, the knowledge society and the information society)--the chances and risks of an educational society will be elicited…

American Vacuum Society: A multidisciplinary organization

International Nuclear Information System (INIS)

Beavis, L.C.

1979-01-01

This presentation is based upon that which was to be given by the Society President at the 25th National Symposium of the American Vacuum Society, 29 November 1978, in San Francisco, California. The talk to the Society by its President was an innovation of the 1979 Program Committee. The intention is that such a presentation be given each year at the awards acceptance plenary session along with those of the Welch and, when appropriate, Gaede--Langmuir awards. To be discussed are the recent highlights of Society activity, the direction the Society is taking, and an example of the multidisciplinary activities of Society members

Refractions of Civil Society

DEFF Research Database (Denmark)

Kuzmanovic, Daniella

The thesis investigates various perceptions of civil society among civic activists in Turkey, and how these perceptions are produced and shaped. The thesis is an anthropological contribution to studies of civil society in general, as well as to studies on political culture in Turkey....

European Respiratory Society statement

DEFF Research Database (Denmark)

Miravitlles, Marc; Dirksen, Asger; Ferrarotti, Ilaria

2017-01-01

lung disease. A large proportion of individuals affected remain undiagnosed and therefore without access to appropriate care and treatment.The most recent international statement on AATD was published by the American Thoracic Society and the European Respiratory Society in 2003. Since then there has...

Registration of six grain sorghum pollinator (R) lines

Science.gov (United States)

Six sorghum [Sorghum bicolor (L.) Moench] pollinators [KS142R (Reg. No. PI XXXX), KS143R (Reg. No. PI XXXX), KS144R (Reg.No. PI XXXX), KS145R (Reg. No. PI XXXX), KS146R (Reg. No. PI XXXX) and KS147R (Reg. No. PI XXXX) were developed from random mating using a recurrent selection followed by pedigree...

Die reg op basiese onderwys in Suid-Afrika

Directory of Open Access Journals (Sweden)

I.J. Oosthuizen

2001-08-01

Full Text Available The right to basic education in South Africa Education is most effective within a culture of human rights. The right to education is one of the internationally recognised fundamental rights of a child. In this article the right to education is discussed against the background of the development of children’s rights since 1924. Special attention is given to the 1989 Convention on the Rights of the Child, consisting of internationally acceptable principles and minimum standards for education and the general welfare of children. In this article “basic education” is first defined, followed by a clarification of the international principle of “free education”. Although free education is not guaranteed by the South African Constitution, everyone has the constitutional right (as well as the obligation to receive basic education. Another prominent aspect of the article is a discussion of the provision of basic education in the learner’s mother tongue, as well as the extent of limitations to the freedom of choice of the language of instruction. This right of all people in the diverse South African society is weighed up against other constitutional principles such as reasonableness, practicability and affirmative action. What must be kept in mind as well, is that the understanding of the Bill of Rights is still in a developmental phase and subject to much interpretation, especially by the Constitutional Court.

American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline.

Science.gov (United States)

Runowicz, Carolyn D; Leach, Corinne R; Henry, N Lynn; Henry, Karen S; Mackey, Heather T; Cowens-Alvarado, Rebecca L; Cannady, Rachel S; Pratt-Chapman, Mandi L; Edge, Stephen B; Jacobs, Linda A; Hurria, Arti; Marks, Lawrence B; LaMonte, Samuel J; Warner, Ellen; Lyman, Gary H; Ganz, Patricia A

2016-02-20

The purpose of the American Cancer Society/American Society of Clinical Oncology Breast Cancer Survivorship Care Guideline is to provide recommendations to assist primary care and other clinicians in the care of female adult survivors of breast cancer. A systematic review of the literature was conducted using PubMed through April 2015. A multidisciplinary expert workgroup with expertise in primary care, gynecology, surgical oncology, medical oncology, radiation oncology, and nursing was formed and tasked with drafting the Breast Cancer Survivorship Care Guideline. A total of 1,073 articles met inclusion criteria; and, after full text review, 237 were included as the evidence base. Patients should undergo regular surveillance for breast cancer recurrence, including evaluation with a cancer-related history and physical examination, and should be screened for new primary breast cancer. Data do not support performing routine laboratory tests or imaging tests in asymptomatic patients to evaluate for breast cancer recurrence. Primary care clinicians should counsel patients about the importance of maintaining a healthy lifestyle, monitor for post-treatment symptoms that can adversely affect quality of life, and monitor for adherence to endocrine therapy. Recommendations provided in this guideline are based on current evidence in the literature and expert consensus opinion. Most of the evidence is not sufficient to warrant a strong evidence-based recommendation. Recommendations on surveillance for breast cancer recurrence, screening for second primary cancers, assessment and management of physical and psychosocial long-term and late effects of breast cancer and its treatment, health promotion, and care coordination/practice implications are made.This guideline was developed through a collaboration between the American Cancer Society and the American Society of Clinical Oncology and has been published jointly by invitation and consent in both CA: A Cancer Journal for

Privacy and the Connected Society

DEFF Research Database (Denmark)

Sørensen, Lene Tolstrup; Khajuria, Samant; Skouby, Knud Erik

The Vision of the 5G enabled connected society is highly based on the evolution and implementation of Internet of Things. This involves, amongst others, a significant raise in devices, sensors and communication in pervasive interconnections as well as cooperation amongst devices and entities across...... the society. Enabling the vision of the connected society, researchers point in the direction of security and privacy as areas to challenge the vision. By use of the Internet of Things reference model as well as the vision of the connected society, this paper identifies privacy of the individual with respect...... to three selected areas: Shopping, connected cars and online gaming. The paper concludes that privacy is a complexity within the connected society vision and that thee is a need for more privacy use cases to shed light on the challenge....

Advancement of Marketing Developing Biotechnology-Based Business

OpenAIRE

Vilmantas, Vaidas; Melnikas, Borisas

2014-01-01

The article, in a complex way, analyzes the needs of marketing improvement in developing biotechnology-based business and highlights its role in the context of modern society and globalization challenges. The article distinguishes between the existing problems of biotechnology business, the present perspectives and specific characteristics of developing the marketing of biotechnological business. The paper represents the possibility of the substantial modernization of marketing tools with reg...

Fluorine Gauche Effect Explained by Electrostatic Polarization Instead of Hyperconjugation: An Interacting Quantum Atoms (IQA) and Relative Energy Gradient (REG) Study.

Science.gov (United States)

Thacker, Joseph C R; Popelier, Paul L A

2018-02-08

We present an interacting quantum atoms (IQA) study of the gauche effect by comparing 1,2-difluoroethane, 1,2-dichloroethane, and three conformers of 1,2,3,4,5,6-hexafluorocyclohexane. In the 1,2-difluoroethane, the gauche effect is observed in that the gauche conformation is more stable than the anti, whereas in 1,2-dichloroethane the opposite is true. The analysis performed here is exhaustive and unbiased thanks to using the recently introduced relative energy gradient (REG) method [ Thacker , J. C. R. ; Popelier , P. L. A. Theor. Chem. Acc . 2017 , 136 , 86 ], as implemented in the in-house program ANANKE. We challenge the common explanation that hyperconjugation is responsible for the gauche stability in 1,2-difluoroethane and instead present electrostatics as the cause of gauche stability. Our explanation of the gauche effect is also is seen in other molecules displaying local gauche conformations, such as the recently synthesized "all-cis" hexafluorocyclohexane and its conformers where all the fluorine atoms are in the equatorial positions. Using our extension of the traditional IQA methodology that allows for the partitioning of electrostatic terms into polarization and charge transfer, we propose that the cause of gauche stability is 1,3 C···F electrostatic polarization interactions. In other words, if a number of fluorine atoms are aligned, then the stability due to polarization of nearby carbon atoms is increased.

World Society and Globalisation

Science.gov (United States)

Wittmann, Veronika

2014-01-01

Purpose: The purpose of this paper is to illustrate discourses on globalisation and world society and to disclose the commonalities and differences of both scientific debates. In particular, it draws attention to theoretical concepts of globalisation and world society. This is considered fruitful for comprehending the complex mechanisms of…

Finnish Society of Soil Sciences

Science.gov (United States)

Rankinen, Katri; Hänninen, Pekka; Soinne, Helena; Leppälammi-Kujansuu, Jaana; Salo, Tapio; Pennanen, Taina

2017-04-01

In 1998 the organization of the International Union of Soil Sciences (IUSS) was renewed to better support national activities. That was also the new start in the operation of the Finnish Society of Soil Sciences, which became affiliated to the IUSS. The society was originally established in 1971 but it remained relatively inactive. Currently, there are around 200 members in the Finnish Society of Soil Sciences. The members of the executive board cover different fields of soil science from geology to microbiology. Mission statement of the society is to promote the soil sciences and their application in Finland, to act as a forum for creation of better links between soil scientists, interested end users and the public, and to promote distribution and appreciation of general and Finnish research findings in soil science. Every second year the society organizes a national two-day long conference. In 2017 the theme 'circular economy' collected all together 57 presentations. The members of the incoming student division carried responsibility in practical co-ordination committee, acting also as session chairs. In the intervening years the society organizes a weekend excursion to neighboring areas. Lately we have explored the use of biochar in landscaping of Stockholm.

Producing Civil Society

DEFF Research Database (Denmark)

Feldt, Liv Egholm; Hein Jessen, Mathias

Since the beginning of the 1990’s, civil society has attracted both scholarly and political interest as the ‘third sphere’ outside the state and the market not only a normatively privileged site of communication and ‘the public sphere’, but also as a resource for democratization processes...... and social cohesion, as well as a provider of welfare services from a welfare state in dire straits. However, such a view upholds a sharp distinction between the three sectors and their distinct logic. This article claims that the separation of spheres is a fundamental part of our ‘social imaginary......’ and as such dominates our way of thinking about civil society. Yet, this view hinders the understanding of how civil society is not a pre-existing or given sphere, but a sphere which is constantly produced both discursively, conceptually and practically. Through two examples; 1,the case of philanthropy in the beginning...

Transformation of Neolithic Societies

DEFF Research Database (Denmark)

Iversen, Rune

and prepared the way for the appearance of Bronze Age societies. The great era of megalithic architecture came to an end as the production and exchange of gold, copper and bronze objects became the driving force in the development of Copper and Bronze Age societies. This development also had a great influence...

Nursing in a postemotional society.

Science.gov (United States)

Herdman, Elizabeth A

2004-07-01

Globalization is often seen as the final stage in the transition towards a market economy. It is argued that a side-effect of globalization is cultural homogeneity and loss of life world, or 'McDonaldization'. McDonaldization represents the rationalization of society in the quest for extreme efficiency. More recently, Mestrović has argued that the rationalization of emotions has also occurred and that Western societies are entering a postemotional phase. In postemotional societies there has been a separation of emotion from action. The result is synthetic, manufactured emotions manipulated and standardized for mass consumption. In this paper I explore what it means to nurse in a 'postemotional society' and what impact this dulling of the emotions has had on a profession that locates 'care' as its central defining concept. My aim is to generate critical discussion of the shape and direction of contemporary society and the role of nursing within it.

What is the Knowledge Society?

Directory of Open Access Journals (Sweden)

Marin Dinu

2008-02-01

Full Text Available This study sets out to establish conceptual delimitations, more concordant to the theoretical acquisitions with regard to the knowledge society. The author considers it opportune to situate in the center of the definition of the concept of knowledge society the problem of prevalence in the typology of resources. Thus, the knowledge society appears as a form of organization in which scientific knowledge predominates, be that informatics as well. The concordances of essence are discovered through the discerning of the functional relationship knowledge society – global society. In the spectrum of meanings specific to this highway of post-postmodernist configuration of the world, the priorities of the project of the second modernity – the paradigmatic matrix of globalization – are approached. In fact, the study argues in favor of refocusing globalization on the humane, on its distinctive values which substantiate and lend sense to the evolutions of the world. Postreferentiality is the rational expression of humanity coming back to itself.

The Knowledge Society: A Sustainability Paradigm

Directory of Open Access Journals (Sweden)

Naim Hamdija Afgan

2010-10-01

Full Text Available This paper defines the knowledge society as a human structured organisation based on contemporary developed knowledge and representing new quality of life support systems. It implies the need for a full understanding of distribution of knowledge, access to information and the capability to transfer information into a knowledge. The understanding of knowledge is the central challenge when defining a knowledge society. From our present perception of knowledge society, it is of interest to emphasize the role of the knowledge society in future development of human society. The life support systems are essential pillars of human society development. In this respect knowledge society represents a new paradigm for future development and it is strongly correlated to sustainable development. For this reason the sustainability paradigm of knowledge society is a potential frame for human society development leading to social cohesion, economic competitiveness and stability, use of resources and economic development, safeguarding biodiversity and the ecosystem.In order to verify the mutual relation between knowledge society and sustainability, we have to introduce the difference between these two terms. The knowledge society is based on the agglomeration of eco-knowledge, env-knowledge and soc-knowledge, it may be evaluated as the complex knowledge of quality of life support systems. We have to introduce metrics which will allow us to present knowledge as the paradigm of the number of indicators for verifying progress made.Sustainability metrics are designed to consolidate measures of economic, environmental and social performance of any system. It can be understood as a pattern for evaluation of the available knowledge about systems and their performance. In particular the decision-making process for the selection of the system under consideration must be based on the available knowledge. The link between knowledge and sustainability makes it possible for

Formation of a collaborative society

OpenAIRE

Buřita, Ladislav; Ondryhal, Vojtěch

2014-01-01

The MilUNI knowledge portal, based on the knowledge base developed in ATOM software has been created at the authors' workplace with the aim to form a collaborative society of military universities. The analysis of the collaborative society concept is presented. The description of the MilUNI project is included. Some areas for university cooperation are proposed, as well as the measures facilitating the formation and development of the collaborative society.

Risk society and amoral morality

Directory of Open Access Journals (Sweden)

Nedeljković Radica M.

2017-01-01

Full Text Available The modern world is the world of change. Modernity changed all aspects of life in width and depth. The changes are so fast and so many people have impression that they are trapped in a multitude of events that they cannot understand nor control. Instead of society as a system, we are talking about society as a network of different relationships of individuals and social groups. Instead of a harmonious society as a space in which the man resides, developing their potential and needs, we are talking about society as a threatening force that destroys everything in its way as 'Moloch' (Giddens, the 'risk society' (Beck in which the doctrine produced in equal measure the conditions for prosperity, but also the risks and destruction; the simulation of society (Baudrillard which glorifies lies and deceit. Instead of society as a community, we are talking about the disappearance of society (Popper. Can we, therefore, rationally understand and express the world, the world of modernity; this world of profound change resembles the maze in which we are lost and wandering without meaning? Starting with Ulrich Beck and his theory of the risk society, the author points out that the way in which the western civilization started, which is imposed as a mandatory form for the rest of the world, leads to amoral morality. The ideology of progress, which is irrational and without a clear vision and clearly defined values, pushes us into an uncertain future of numerous risks and ever growing individualism. Thus we come to the conviction that without common values, collective values, we are lost in this world of risk. Solidarity and trust are the key values for the stable community, but they are non-existent in the risk society dominated by individualism. In the period of uncertainty in the risk society, only religion provides a healthy basis for communal living. Therefore, the way out of the crisis is not in politics, which is placed at the service of the economy, but

Residential landscapes and house societies of the late prehistoric Society Islands

International Nuclear Information System (INIS)

Kahn, J.G.; Kirch, P.V.

2013-01-01

We extend the 'house society' perspective to one of the most complex Eastern Polynesian chiefdoms, the Society Islands. Employing a landscape approach, we argue that competing elites used the flexibility of the 'house society' structure and its landed estates to promulgate and manipulate status differences. Our study documents how the social hierarchy and its ideological underpinnings were materialised in archaeologically visible ways, including investments in residential landscapes, site proxemics, and construction sequences. While communal investments in the landed material estate were staged over a few centuries, investments in the house's ideology and corporate identity were established early on. Differences in house rank afforded some houses greater access to essential resources and facilitated their abilities to maintain and extend their corporate group, while affording them greater access to labor and continued wealth production over time. Our case study exemplifies the significant role that small-scale relations - quotidian interactions within neighborhoods - played as sources of social power. (author). 105 refs., 9 figs., 3 tabs.

Marketing - tool transformation of traditional societies

Directory of Open Access Journals (Sweden)

V. D. Shinkarenko

2013-12-01

Full Text Available The article considers the influence of marketing on the TRANS­formation of a traditional society with its traditional values in a society of consumption. The de­velopment of capitalism inevitably leads to changes in the socio­political order of the whole modern world. This leads to the fact that the disappearance of the traditional elements of culture, crafts, songs and dances, rites, destroyed traditional norms and values, beliefs, moral and ethical values. Instead of the traditional culture is formed by the mass culture, society develops consumption goods and becoming all that you can sell. Marketing is one tool for the formation of a society of consumption, but it also performs other less prominent function transforms the traditional society into a consumer society with its values, mythology, norms and moral principles.

Science communication at scientific societies.

Science.gov (United States)

Braha, Jeanne

2017-10-01

Scientific societies can play a key role in bridging the research and practice of scientists' engagement of public audiences. Societies are beginning to support translation of science communication research, connections between scientists and audiences, and the creation of opportunities for scientists to engage publics without extensive customization. This article suggests roles, strategies, and mechanisms for scientific societies to promote and enhance their member's engagement of public audiences. Copyright © 2017 Elsevier Ltd. All rights reserved.

Evolving society and mental health

Directory of Open Access Journals (Sweden)

Dipesh Bhagabati

2016-07-01

Full Text Available Numerous issues related to culture, occupation, gender, caste, and health, to name a few, have faced harshness of society from time immemorial. Reasons are debatable, ranging from somewhat understandable to completely unacceptable. There is no doubt that society is dynamic and it has changed its view on many of the issues with passing time. Mental health is one such issue which society has neglected for quite a long time. Even today, mental health and mentally ill people face stigma and discrimination in their family, society, and at their workplace. People do not feel comfortable talking about mental health, even if they know that there cannot be any health without a healthy mind. But, as Albert Einstein has said “learn from yesterday, live for today, and hope for tomorrow”, everything is not lost. The mentally ill patients who were once abandoned and left on their own have now started to get humane care and attention. This article discusses this very pertinent topic of changing society and mental health.

Civil Society

Science.gov (United States)

Social Media Facebook @oasofficial Facebook Twitter @oas_official Twitter Newsletters Documents OAS Technology Social Development Summits of the Americas Sustainable Development T Telecommunications Terrorism Tourism Trade Treaties and Agreements W Women Y Youth Strategic Partners Permanent Observers Civil Society

Manipulating the Circadian and Sleep Cycles to Protect Against Metabolic Disease

OpenAIRE

Nohara, Kazunari; Yoo, Seung-Hee; Chen, Zheng (Jake)

2015-01-01

Modernization of human society parallels an epidemic of metabolic disorders including obesity. Apart from excess caloric intake, a 24/7 lifestyle poses another important challenge to our metabolic health. Recent research under both laboratory and epidemiological settings has indicated that abnormal temporal organization of sleep and wakeful activities including food intake is a significant risk factor for metabolic disease. The circadian clock system is our intrinsic biological timer that reg...

The residual and direct effects of reduced-risk and conventional miticides on twospotted spider mites, Tetranychus urticae (Acari: Tetranychidae) and predatory mites (Acari: Phytoseiidae)

International Nuclear Information System (INIS)

Liburd, O.E.; White, J.C.; Rhodes, E.M.; Browdy, A.A.

2007-01-01

The residual effects of several reduced-risk and conventional miticides were evaluated in strawberries (Fragaria × ananassa Duchesne) on the twospotted spider mite (TSSM), Tetranychus urticae Koch (Acari: Tetranychidae) and on 2 predatory mites, Neoseiulus californicus McGregor and Phytoseiulus persimilis Athias-Henriot (Acari: Phytoseiidae). Experiments were conducted in the laboratory and greenhouse. The greenhouse experiments also tested the direct effects of the miticides on TSSM. The efficacy of conventional and reduced-risk miticides was evaluated on strawberry leaf discs and on whole plants for control of TSSM. Furthermore, the residual effects of these miticides were evaluated on whole strawberry plants against selective predatory mites. For TSSM, 5 treatments were evaluated: a conventional miticide; fenbutatin-oxide (Vendex[reg]) and 3 reduced-risk miticides; binfenazate (Acramite 50WP[reg]), activated garlic extract (Repel[reg]), sesame seed and castor oil (Wipeout[reg]), and a water-treated control. For predatory mites, the residual effects of only Acramite[reg] and Vendex[reg] were evaluated. Acramite[reg] was the most effective acaricide in reducing TSSM populations in both the laboratory and greenhouse experiments. Vendex[reg] and Wipeout[reg] were also effective in the laboratory, but did not cause significant reduction of TSSM in the greenhouse. Repel[reg] was the least effective of the 4 pesticides evaluated. Neither Acramite[reg] nor Vendex[reg] had a significant effect on either predatory mite species. However, there appeared to be more predatory mites on the Vendex[reg]-treated plants than on the Acramite[reg]-treated plants. There were significantly more predatory mites of both species on the cue plants, which were inoculated with TSSM versus the non-cue plants, which were not inoculated. (author) [es

Science in Society in Europe

DEFF Research Database (Denmark)

Mejlgaard, Niels; Bloch, Carter Walter

2012-01-01

This paper introduces a special section of Science and Public Policy on science in society in Europe. Based on extensive data collected for the Monitoring Policy and Research Activities on Science in Society in Europe (MASIS) project, contributions to this special section explore pertinent issues...... related to the location, role and responsibility of science across EU member states and associated countries. By developing analytical typologies and classifying countries, the collection of papers provides a novel and detailed picture of Europe. It reveals considerable variation regarding...... the interactions of science and society at the national level, and it offers a platform for international learning. The identification of patterns and trends concerning the place of science in society may also feed into emerging European discussions about ‘responsible research and innovation’....

Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK rats.

Directory of Open Access Journals (Sweden)

Sophie Calderari

Full Text Available Regenerating (REG proteins are associated with islet development, β-cell damage, diabetes and pancreatitis. Particularly, REG-1 and REG-3-beta are involved in cell growth/survival and/or inflammation and the Reg1 promoter contains interleukin-6 (IL-6-responsive elements. We showed by transcriptome analysis that islets of Goto-Kakizaki (GK rats, a model of spontaneous type 2 diabetes, overexpress Reg1, 3α, 3β and 3γ, vs Wistar islets. Goto-Kakizaki rat islets also exhibit increased cytokine/chemokine expression/release, particularly IL-6. Here we analyzed Reg1 and Reg3β expression and REG-1 immuno-localization in the GK rat pancreas in relationship with inflammation. Isolated pancreatic islets and acinar tissue from male adult Wistar and diabetic GK rats were used for quantitative RT-PCR analysis. REG-1 immunohistochemistry was performed on paraffin sections with a monoclonal anti-rat REG-1 antibody. Islet cytokine/chemokine release was measured after 48 h-culture. Islet macrophage-positive area was quantified on cryostat sections using anti-CD68 and major histocompatibility complex (MHC class II antibodies. Pancreatic exocrine-to-endocrine Reg1 and Reg3β mRNA ratios were markedly increased in Wistar vs GK rats. Conversely, both genes were upregulated in isolated GK rat islets. These findings were unexpected, because Reg genes are expressed in the pancreatic acinar tissue. However, we observed REG-1 protein labeling in acinar peri-ductal tissue close to islets and around large, often disorganized, GK rat islets, which may retain acinar cells due to their irregular shape. These large islets also showed peri-islet macrophage infiltration and increased release of various cytokines/chemokines, particularly IL-6. Thus, IL-6 might potentially trigger acinar REG-1 expression and secretion in the vicinity of large diabetic GK rat islets. This increased acinar REG-1 expression might reflect an adaptive though unsuccessful response to deleterious

Network Society

DEFF Research Database (Denmark)

Clausen, Lars; Tække, Jesper

2017-01-01

the five strands of theory on the network society. Each theoretical position has its specific implications for acting toward strategic goals. In its entirety, the five perspectives give a thorough understanding of the conditions for successful strategic communication in the 21st century....

Network Society

DEFF Research Database (Denmark)

Clausen, Lars; Tække, Jesper

2018-01-01

the five strands of theory on the network society. Each theoretical position has its specific implications for acting toward strategic goals. In its entirety, the five perspectives give a thorough understanding of the conditions for successful strategic communication in the 21st century....

Abortion in a just society.

Science.gov (United States)

Hunt, M E

1993-01-01

A female Catholic theologian imagines a just society that does not judge women who decide to undergo an abortion. The Church, practitioners, and the courts must trust that women do make person-enhancing choices about the quality of life. In the last 15 years most progress in securing a woman's right to abortion has been limited to white, well-educated, and middle or upper middle class women. A just society would consider reproductive options a human right. Abortion providers are examples of a move to a just society; they are committed to women's well-being. There are some facts that make one pessimistic about achieving abortion in a just society. The US Supreme Court plans to review important decisions establishing abortion as a civil right. Further, some men insist on suing women who want to make their own reproductive decisions--an anti-choice tactic to wear away women's right to reproductive choice. Bombings of abortion clinics and harassment campaigns by anti-choice groups are common. These behaviors strain pro-choice proponents emotionally, psychically, and spiritually. Their tactics often lead to theologians practicing self-censorship because they fear backlash. Abortion providers also do this. Further, the reaction to AIDS is that sex is bad. Anti-abortion groups use AIDS to further their campaigns, claiming that AIDS is a punishment for sex. Strategies working towards abortion in a just society should be education and persuasion of policymakers and citizens about women's right to choose, since they are the ones most affected by abortion. Moreover, only women can secure their rights to abortion. In a just society, every health maintenance organization, insurance company, and group practice would consider abortion a normal service. A just society provides for the survival needs of the most marginalized.

A FUTURE APPROACHES, SOCIAL ORGANIZATION AND THEIR ECONOMIC CONSEQUENCES OF THE INFORMATIONAL SOCIETY – KNOWLEDGE SOCIETY

Directory of Open Access Journals (Sweden)

NICULAE DAVIDESCU

2011-04-01

Full Text Available The paper is the result of scientific study under doctoral thesis “Information Society and its Economic Effects” and contains seven sections: -section 1: “Globalization, Development and Information Society”; -section 2: “The Impact of the “Digital Divide” and “Digital Inequality” Phenomena” ; -section 3: “Information Society –Knowledge Society, Definition, Objectives and Strategies” ; -section 4: “Social Structures and New Life Patterns in Information Society” ; -section 5: “Virtual Organizations, Activities and Businesses” ; -section 6: “Strategies, Programmes and Courses of the Information Society Approach” ; -section 7: “The Economic Effects Foreseeable through the Implementation of Information Society–Knowledge Society”.

Dios, Patria, Autoridad: la Iglesia Católica y la fascistización de los regímenes ibéricos, 1933-1945

Directory of Open Access Journals (Sweden)

Manuel Loff

2013-12-01

Full Text Available La crisis de los sistemas liberales ibéricos en la Europa de entreguerras es especialmente interesante por el papel específico que ocupa en ella el componente católico de laidentidad y de las coaliciones que sostuvieron los dos regímenes autoritarios. El catolicismo político tuvo un papel muy relevante en el proceso de modernización de las derechas españolas y portuguesas de la primera posguerra. Salazar y Franco presentaron los regímenes que ellosmismos construyeron y sobre los que gobernaron como siendo intrínsicamente católicos, y los católicos fueron actoresprincipales de las coaliciones políticas y sociales que sostuvieron ambos dictadores. En su lucha contra la Primera República Portuguesa (1910-26 y la Segunda República Española (1931-39, las fuerzas políticas conservadoras y de extrema derecha concedieron un papel estratégico a los católicos politicamente organizados en lo que se refiere a la movilización de las masas y en la constitución de un amplia coalición que pudiese crear una alternativa sólida a la democracia liberal y a un movimento obrero cada día más fuerte. En los años centrales de la «Era del Fascismo», las derechas católicas ibéricas y la jerarquía de la Iglesia sancionaron un giro muy notorio hacia una lectura crecientemente fascistizada del contexto político europeo posterior a la Revolución Soviética.The crisis of the Iberian liberal systems in inter-war Europe is especially interesting to study because of the specific role ofthe Catholic component of both the sustaining political coalition and the identity of these two of the European 20th century authoritarian regimes. Political Catholicism was a major actor in the modernisation process of Spanish and Portuguese post-World War I rightwing movements. Salazar and Franco presented the regimes they built up and ruled upon as being intrinsically catholic, and Catholics were major partners in the political and

Programa para el cálculo de los regímenes de operación de la red soterrada

Directory of Open Access Journals (Sweden)

Manuel Barroso Baeza

2011-03-01

Full Text Available Este trabajo tiene como objetivo el desarrollo de software para el análisis de los regímenes de trabajo normalesde la red soterrada; específicamente abarca el desarrollo y adecuación de algoritmos para flujo de carga,elaborando el producto informático propuesto empleando las técnicas de la programación visual. El programaobtenido permite analizar estudios completos del comportamiento de la red soterrada, nunca antes posible,pues se carecía de la herramienta adecuada para realizar tales estudios, o bien por falta de capacidadsuficiente en cuanto a memoria requerida para modelar la red completa , lo cual sucedió en las décadasanteriores o porque los programas que existían entonces eran desarrollados para la transmisión.  This work has as objectives the software development for the analysis of the normal load flow of the undergroundsecondary network, specifically sandal the development and adaptation of algorithms for load flow, elaborating theproposed computer product using the techniques of the visual programming. The obtained program allows toanalyze complete studies of the net behavior it was never before possible, because you lacked the appropriatetool to carry out such studies, or for lack of enough capacity as for memory required to model the complete net,that which happened in the previous decades or because the programs that existed then were developed for thetransmission. As a result final of this project a software will be reached that using a base data common to othertechnical studies, facilitate to make any of the mentioned analysis, responding to the particularities of the undergroundsecondary network.

Health Physics Society: origins and development

International Nuclear Information System (INIS)

Kathren, R.L.

1978-08-01

Events leading up to the birth of the Health Physics Society in June, 1955, are reviewed. Membership requirements, chapters, and sections are discussed. An international organization, International Radiation Protection Association (IRPA), founded in 1963, was the outgrowth of the Health Physics Society. Other events in the history of the organization, such as the initiation of publishing of a society journal in 1957, the employment of the first Executive Secretary in 1965, and the establishment of awards, are reviewed. The two appendixes include lists of the officers of the society and award recipients

Nationalistic Education in a Global Society.

Science.gov (United States)

Nelson, Jack L.

The appropriateness of nationalistic education in the modern global society is questioned since nation-states may be superceded by supra-national or global structures. Schools provide a place for society to prepare younger generations to cherish and protect the interests of that society. Human history reflects this trend as it moves from parental…

The use of HANDIDET reg-sign non-electric detonator assemblies to reduce blast-induced overpressure at AECL's Underground Research Laboratory

International Nuclear Information System (INIS)

Onagi, D.P.; Keith, S.G.; Kuzyk, G.W.

1996-01-01

A number of aspects of the Canadian concept for nuclear fuel waste disposal are being assessed by Atomic Energy of Canada Limited (AECL) in a series of experiments at its Underground Research Laboratory (URL) near Lac du Bonnet, Manitoba, Canada. One of the major objectives of the work being carried out at the URL is to develop and evaluate the methods and technology to ensure safe, permanent disposal of Canada's nuclear fuel waste. In 1994, AECL excavated access tunnels and a laboratory room for the Quarried Block Fracture Migration Experiment (QBFME) at the 240 Level of the URL. This facility will be used to study the transport of radionuclides in natural fractures in quarried blocks of granite under in-situ groundwater conditions. The experiment is being carried out under a cooperative agreement with the Japan Atomic Energy Research Institute. The excavation of the QBFME access tunnels and laboratory was carried out using controlled blasting techniques that minimized blast-induced overpressure which could have damaged or interrupted other ongoing experiments in the vicinity. The majority of the blasts used conventional long delay non-electric detonators but a number of blasts were carried out using HANDIDET 250/6000 non-electric long delay detonator assemblies and HTD reg-sign non-electric short delay trunkline detonator assemblies. The tunnel and laboratory excavation was monitored to determine the levels of blast-induced overpressure. This paper describes the blasting and monitoring results of the blasts using HANDIDET non-electric detonator assemblies and the effectiveness of these detonators in reducing blast-induced overpressure

Changing of the social structure and lifelong education –\tFrom the industrial society to the knowledge society

Directory of Open Access Journals (Sweden)

Ana Krajnc

2010-07-01

Full Text Available Social structures are changing. The industrial society is a hierarchical pyramid with separate social classes and the law of limited social mobility. The social status tended to be stable and was transmitted from parents to children. The information society, the knowledge society, the society in change and the risk society, is a turmoil of centripetal and centrifugal social forces. The social status of each individual, ranging from the highest ­ with their place in the very heart of the society­ to the lowest, is temporary. The main production resource in the accelerated economy of the information society is knowledge. Renewing competences is essential in order to preserve one’s social status in the social spiral; lagging behind in knowledge and in personal growth , on the other hand, shoves one off to the margins of society. The way back up to a more prestigious position can be achieved through education. Education systems differ from state to state. Some are losing their legitimacy since they fail to train young people for new methods of work and survival; they are an obstacle to the development of the most immanent properties in the new society, as e.g., innovativeness, independence, decision­making ability, creativity. If young people drop out from school too early, before they complete a four­year secondary school, they are surrendered to the street and crime. Manual workers are being discarded on a large scale to find themselves on the margins of society, among the "service proletariat" depending on the handouts of the welfare state. Whereas the GNP is increasing, the wealth redistribution stick to the old formulas and are widening the gap between the poor and the rich. The information society is opening up countless new opportunities, but it is also bringing new responsibilities. Work is becoming more humane, with the "brain" winning over "brawn".

Searching for Women in Korean Scientific Societies

Indian Academy of Sciences (India)

ranjeetha

III. Female Participation in S&E Societies. 16. ▫ the Committee for Women in KOFST (the Korean Federation of Science and Technology Societies) in 2012. Size of Responding Societies. ▫. Monitored gender ratio of committee members of its member societies in. Science and engineering. 52. 60. 80. 100. 120. Total Number.

A former Romanian scientific society: The Society of Physical sciences (1890-1910

Directory of Open Access Journals (Sweden)

IAVORENCIUC GEORGE ANDREI

2015-12-01

Full Text Available The Society of Physical sciences (phisycs, chemistry and mineralogy has been an important Romanian scientific society since its establishment, in 1890 until the middle of the twentieth century. This paper seeks to provide an analysis of its activity in the first two decades of existence, a less studied period, namely how its enterprises contributed to the dissemination and spread of the latest scientific ideas within Romania’s culture. The society was founded at the initiative of some of the most proeminent Romanian scientists of that period and, until the end of the nineteenth century, it expanded its sphere of activity by including sections on mathemathics and natural history. Therefore, its activity, exemplified by public conferences, presentation of members’ personal scientific endeavors, intellectual debates or scientific missions, reflected the general development of physical sciences in Romania in that epoch. This research is based mostly on a close scrutiny of society’s scientific journal.

Civil Society Participation at CONFINTEA VI

Science.gov (United States)

Haddad, Sergio

2012-01-01

This article analyzes the participation of civil society in the Sixth International Conference on Adult Education held in Belem do Para, Brazil, 1-4 December 2009. As a foundation, the discussion first illuminates the important role that civil society in general plays in democratic issues and the relation between the state and society followed by…

Assessment of two versions of regional climate model in simulating the Indian Summer Monsoon over South Asia CORDEX domain

Science.gov (United States)

Pattnayak, K. C.; Panda, S. K.; Saraswat, Vaishali; Dash, S. K.

2018-04-01

This study assess the performance of two versions of Regional Climate Model (RegCM) in simulating the Indian summer monsoon over South Asia for the period 1998 to 2003 with an aim of conducting future climate change simulations. Two sets of experiments were carried out with two different versions of RegCM (viz. RegCM4.2 and RegCM4.3) with the lateral boundary forcings provided from European Center for Medium Range Weather Forecast Reanalysis (ERA-interim) at 50 km horizontal resolution. The major updates in RegCM4.3 in comparison to the older version RegCM4.2 are the inclusion of measured solar irradiance in place of hardcoded solar constant and additional layers in the stratosphere. The analysis shows that the Indian summer monsoon rainfall, moisture flux and surface net downward shortwave flux are better represented in RegCM4.3 than that in the RegCM4.2 simulations. Excessive moisture flux in the RegCM4.2 simulation over the northern Arabian Sea and Peninsular India resulted in an overestimation of rainfall over the Western Ghats, Peninsular region as a result of which the all India rainfall has been overestimated. RegCM4.3 has performed well over India as a whole as well as its four rainfall homogenous zones in reproducing the mean monsoon rainfall and inter-annual variation of rainfall. Further, the monsoon onset, low-level Somali Jet and the upper level tropical easterly jet are better represented in the RegCM4.3 than RegCM4.2. Thus, RegCM4.3 has performed better in simulating the mean summer monsoon circulation over the South Asia. Hence, RegCM4.3 may be used to study the future climate change over the South Asia.

European Society of Gastrointestinal Endoscopy, European Society of Gastroenterology and Endoscopy Nurses and Associates, and the European Society of Anaesthesiology Guideline: Non-anaesthesiologist administration of propofol for GI endoscopy

DEFF Research Database (Denmark)

Dumonceau, J.M.; Riphaus, A.; Aparicio, J.R.

2010-01-01

), the European Society of Gastroenterology and Endoscopy Nurses and Associates (ESGENA) and the European Society of Anaesthesiology (ESA). These three societies have endorsed the present guideline.The guideline is published simultaneously in the Journals Endoscopy and European Journal of Anaesthesiology....

Information Era. Conscience Society. Creativity

Directory of Open Access Journals (Sweden)

Dumitru TODOROI

2011-01-01

Full Text Available ttendees will learn about the research and development which will be effected by scientists in the branch of Conscience Society creation in next decades of XXI century. Conscience is usually seen as linked to a morality inherent in all humans, to a beneficent universe and/or to divinity. It is increasingly conceived of as applying to the world as a whole and as a main feature of conscience society. It has motivated its numerous models, characteristics and functions of Conscience for creation the societal intelligent adaptable information systems in Conscience Society. The moral life is a vital part for the world to maintain a Conscience (civilized Society, so always keep in mind to: accept differences in others; respond promptly to others; leave some "free" time; care about others as if they were you; treat everyone similarly; never engage in violent acts; have an inner sense of thankfulness; have a sense of commitment. Creativity is a result of brain activity which differentiates individuals and could ensure an important competitive advantage for persons, for companies, for Society in general, and for Conscience Society in special. Very innovative branches – like software industry, computer industry, car industry – consider creativity as the key of business success. Natural Intelligence’ Creativity can develop basic creative activities, but Artificial Intelligence’ Creativity, and, especially, Conscience Intelligence’ Creativity should be developed and they could be enhanced over the level of Natural Intelligence. The basic idea for present communication represent the research results communicated at the last two annual AESM conferences [1] [2].

Experts in science and society

CERN Document Server

Gigerenzer, Gerd

2004-01-01

In today's complex world, we have come to rely increasingly on those who have expertise in specific areas and can bring their knowledge to bear on crucial social, political and scientific questions. Taking the viewpoint that experts are consulted when there is something important at stake for an individual, a group, or society at large, Experts in Science and Society explores expertise as a relational concept. How do experts balance their commitment to science with that to society? How does a society actually determine that a person has expertise? What personal traits are valued in an expert? From where does the expert derive authority? What makes new forms of expertise emerge? These and related questions are addressed from a wide range of areas in order to be inclusive, as well as to demonstrate similarities across areas. Likewise, in order to be culturally comparative, this volume includes examples and discussions of experts in different countries and even in different time periods. The topics include the r...

Role of regulatory T cells in acute myeloid leukemia patients undergoing relapse-preventive immunotherapy.

Science.gov (United States)

Sander, Frida Ewald; Nilsson, Malin; Rydström, Anna; Aurelius, Johan; Riise, Rebecca E; Movitz, Charlotta; Bernson, Elin; Kiffin, Roberta; Ståhlberg, Anders; Brune, Mats; Foà, Robin; Hellstrand, Kristoffer; Thorén, Fredrik B; Martner, Anna

2017-11-01

Regulatory T cells (T regs ) have been proposed to dampen functions of anti-neoplastic immune cells and thus promote cancer progression. In a phase IV trial (Re:Mission Trial, NCT01347996, http://www.clinicaltrials.gov ) 84 patients (age 18-79) with acute myeloid leukemia (AML) in first complete remission (CR) received ten consecutive 3-week cycles of immunotherapy with histamine dihydrochloride (HDC) and low-dose interleukin-2 (IL-2) to prevent relapse of leukemia in the post-consolidation phase. This study aimed at defining the features, function and dynamics of Foxp3 + CD25 high CD4 + T regs during immunotherapy and to determine the potential impact of T regs on relapse risk and survival. We observed a pronounced increase in T reg counts in peripheral blood during initial cycles of HDC/IL-2. The accumulating T regs resembled thymic-derived natural T regs (nT regs ), showed augmented expression of CTLA-4 and suppressed the cell cycle proliferation of conventional T cells ex vivo. Relapse of AML was not prognosticated by T reg counts at onset of treatment or after the first cycle of immunotherapy. However, the magnitude of T reg induction was diminished in subsequent treatment cycles. Exploratory analyses implied that a reduced expansion of T regs in later treatment cycles and a short T reg telomere length were significantly associated with a favorable clinical outcome. Our results suggest that immunotherapy with HDC/IL-2 in AML entails induction of immunosuppressive T regs that may be targeted for improved anti-leukemic efficiency.

Public Libraries in postindustrial societies

DEFF Research Database (Denmark)

Elbeshausen, Hans

2015-01-01

The article’s focus is on how public libraries are affected by structural changes in the wake of the transition to the knowledge society. Their attempts to match the knowledge society are illustrated by processes of sensemaking and sensegiving made in public libraries in Canada, the UK and Denmark....

ROMANIAN KNOWLEDGE SOCIETY DEVELOPMENT. A PROPOSAL

Directory of Open Access Journals (Sweden)

Mirela CERKEZ

2016-06-01

Full Text Available This article is an argument for the applicability of the Finnish model of knowledge society oriented public policy-making and not a detailed recommendation on the specific steps Romania should make in order to become a knowledge society. The article is elaborated as a synthesis of the Finnish knowledge society oriented public policies and an analysis of the adequacy of policy transfers from Finland to Romania. Data on Romania are not rich as the task of the article is not to make a diagnosis on Romania’s stage of development. Its main contribution consists of the identification of Finnish public measures meant to foster knowledge society that may be a best practice example for Romania. The introductory part briefly introduces the reader into the theoretical understanding of the concept of knowledge society. Then, I argue that there are several types of knowledge societies and Romania should look for European examples given the resemblance of the starting conditions. The main part of the paper presents the Finnish knowledge society development as an experience modeled by public intervention and I mirror these developments with the Romanian case. In the end, I explore the differences between the two countries that may interfere with the application of the Finnish model. Still, my conclusion is that those differences do not make the Finnish model less applicable. The efforts might need to be more intense and the results might show up later.

Joint Annual Meeting of the Austrian Physical Society and the Swiss Physical Society together with the Austrian and Swiss Societies for Astronomy and Astrophysics

International Nuclear Information System (INIS)

2013-01-01

The Joint Annual Meeting of the Austrian Physical Society and the Swiss Physical Society was organized together with both national societies of Astronomy and Astrophysics (SSAA and ÖGAA) at the Johannes Kepler University Linz, Altenberger Straße 69, 4040 Linz, Austria. The plenary sessions gave an overview of the present status of research in quantum mechanics, particle, atomic and molecular physics. The topical sessions were dedicated to: nuclear, particle- and astro particle physics; physics teachers; acoustics; atoms, molecules, quantum optics and plasmas; solid state physics and research with neutron and synchrotron radiation; history of physics; medical, bio and environmental physics; surfaces, interfaces and thin films; careers in physics. There were special sessions on thermoelectrics and photovoltaics. In addition to the regular program, an Energy Day (Energietag) with several parallel sessions on recent topics of energy generation, -transport and -storage was jointly organized by the Energy and Industry Subdivisions of the Austrian Physical Society and by the Johannes Kepler Universität Linz. Those contributions which are in the INIS subject scope are indexed individually

The governance of cooperative societies

Directory of Open Access Journals (Sweden)

Yaiza Juanes Sobradillo

2005-12-01

Full Text Available The present work aims to expose the appropriate legislation for cooperative societies to which Article 129 of the Spanish Constitution refers, deepen the analysis of the organs of management and control based on the Spanish and Basque Laws on Cooperatives and the Statute for the European Cooperative Societies.

Beyond strong and weak: rethinking postdictatorship civil societies.

Science.gov (United States)

Riley, Dylan; Fernández, Juan J

2014-09-01

What is the impact of dictatorships on postdictatorial civil societies? Bottom-up theories suggest that totalitarian dictatorships destroy civil society while authoritarian ones allow for its development. Top-down theories of civil society suggest that totalitarianism can create civil societies while authoritarianism is unlikely to. This article argues that both these perspectives suffer from a one-dimensional understanding of civil society that conflates strength and autonomy. Accordingly we distinguish these two dimensions and argue that totalitarian dictatorships tend to create organizationally strong but heteronomous civil societies, while authoritarian ones tend to create relatively autonomous but organizationally weak civil societies. We then test this conceptualization by closely examining the historical connection between dictatorship and civil society development in Italy (a posttotalitarian case) and Spain (a postauthoritarian one). Our article concludes by reflecting on the implications of our argument for democratic theory, civil society theory, and theories of regime variation.

Kosovar Society through Secularism and Religion

Directory of Open Access Journals (Sweden)

MSc. Dritero Arifi

2013-12-01

Full Text Available This paper will analyze the importance and the effects of religion, in Kosovar society. A great part of the paper, will analyze the social and the political relations in Post-War Kosovo. Initially it will elaborate religion and secularism, especially in theoreticall aspect, what impact have these definitions in modern societies. In order to explain what the importance of the religion in Kosovo is, we will focus on analyzing ethnical, social and political relations within Kosovo society. A considerable component of the paper is also, the elaboration of secularism in Kosovo conditions. This implies that the formulation of the problem and the objective of this research, are the substance of the paper’s theme, which is, religion in Kosovo; its definition and the outlook of the Kosovar society on religion. Is Kosovo post-war society more or less religious? That means the elements of Religions and Secularism will be part of the analysis of developments in post-war Kosovo.

Does gender bias influence awards given by societies?

Science.gov (United States)

Holmes, Mary Anne; Asher, Pranoti; Farrington, John; Fine, Rana; Leinen, Margaret S.; LeBoy, Phoebe

2011-11-01

AGU is a participant in a U.S. National Science Foundation (NSF)-funded project called Advancing Ways of Awarding Recognition in Disciplinary Societies (AWARDS), which seeks to examine whether gender bias affects selection of recipients of society awards. AGU is interested in learning why there is a higher proportion of female recipients of service and education awards over the past 2 decades. Combined with a lower rate of receipt of research awards, these results suggest that implicit (subconscious) bias in favor of male candidates still influences awardee selection. Six other professional societies (American Chemical Society, American Mathematical Society, American Society of Anesthesiologists, Mathematical Association of America, Society for Neuroscience, and Society for Industrial and Applied Mathematics) are participating in the project. Volunteers from each participant society attended an Association for Women in Science (AWIS)-sponsored workshop in May 2010 to examine data and review literature on best practices for fair selection of society awardees. A draft proposal for implementing these practices will be brought before the AGU Council and the Honors and Recognition Committee at their upcoming meetings.

75 FR 76282 - Domestic Shipping Services Pricing and Mailing Standards Changes

Science.gov (United States)

2010-12-08

... United States Postal Service, Domestic Mail Manual (DMM[reg]), to reflect changes to prices and mailing standards for the following Shipping Services: Express Mail[reg], Priority Mail[reg], Parcel Select[reg... following changes to Mailing Standards of the United States Postal Service, Domestic Mail Manual (DMM...

[Gender equality activity in the Bioimaging Society].

Science.gov (United States)

Suzaki, Etsuko

2013-09-01

Gender equality activity in the Bioimaging Society was initiated in 2005 when it joined the Japan Inter-Society Liaison Association Committee for Promoting Equal Participation of Men and Women in Science and Engineering (EPMEWSE). The Gender Equality Committee of the Bioimaging Society is acting on this issue by following the policy of the EPMEWSE, and has also been planning and conducting lectures at annual meetings of the society to gain the understanding, consents, and cooperation of the members of the society to become conscious of gender equality. Women's participation in the society has been promoted through the activities of the Gender Equality Committee, and the number of women officers in the society has since increased from two women out of 40 members in 2005 to five out of 44 in 2013. The activities of the Gender Equality Committee of the Japanese Association of Anatomists (JAA) have just started. There are more than 400 women belonging to the JAA. When these women members join together and collaborate, women's participation in the JAA will increase.

Sustainable Society Formed by Unselfish Agents

Science.gov (United States)

Kikuchi, Toshiko

It has been pointed out that if the social configuration of the three relations (market, communal and obligatory relations) is not balanced, a market based society as a total system fails. Using multi-agent simulations, this paper shows that a sustainable society is formed when all three relations are integrated and function respectively. When agent trades are based on the market mechanism (i.e., agents act in their own interest and thus only market relations exist), weak agents who cannot perform transactions die. If a compulsory tax is imposed to enable all weak agents to survive (i.e., obligatory relations exist), then the fiscal deficit increases. On the other hand, if agents who have excess income undertake the unselfish action of distributing their surplus to the weak agents (i.e., communal relations exist), then trade volume increases. It is shown that the existence of unselfish agents is necessary for the realization of a sustainable society. However, the survival of all agents is difficult in a communal society. In an artificial society, for all agents survive and fiscal balance to be maintained, all three social relations need to be fully integrated. These results show that adjusting the balance of the three social relations well lead to the realization of a sustainable society.

An official American thoracic society/European respiratory society statement: Key concepts and advances in pulmonary rehabilitation

NARCIS (Netherlands)

M.A. Spruit (Martijn); S.J. Singh (Sally); C. Garvey (Chris); R. Zu Wallack (Richard); L. Nici (Linda); C. Rochester (Carolyn); K. Hill (Kylie); A.E. Holland (Anne); S.C. Lareau (Suzanne); W.D.-C. Man (William); F. Pitta (Fabio); L. Sewell (Louise); J. Raskin (Jonathan); J. Bourbeau (Jean); R. Crouch (Rebecca); F.M.E. Franssen (Frits); R. Casaburi (Richard); J.H. Vercoulen (Jan); I. Vogiatzis (Ioannis); R.A.A.M. Gosselink (Rik); E.M. Clini (Enrico); T.W. Effing (Tanja); F. Maltais (François); J. van der Palen (Job); T. Troosters; D.J.A. Janssen (Daisy); E. Collins (Eileen); J. Garcia-Aymerich (Judith); D. Brooks (Dina); B.F. Fahy (Bonnie); M.A. Puhan (Milo); M. Hoogendoorn (Martine); R. Garrod (Rachel); A.M.W.J. Schols (Annemie); B. Carlin (Brian); R. Benzo (Roberto); P. Meek (Paula); M. Morgan (Mike); M.P.M.H. Rutten-van Mölken (Maureen); A.L. Ries (Andrew); B. Make (Barry); R.S. Goldstein (Roger); C.A. Dowson (Claire); J.L. Brozek (Jan); C.F. Donner (Claudio); E.F.M. Wouters (Emiel)

2013-01-01

textabstractBackground: Pulmonary rehabilitation is recognized as a core component of themanagement of individuals with chronic respiratory disease. Since the 2006 American Thoracic Society (ATS)/European Respiratory Society (ERS) Statement on Pulmonary Rehabilitation, there has been considerable

Education for a Learning Society.

Science.gov (United States)

Tempero, Howard E., Ed.

The essays contained in this booklet are 1) "Education for a 'Learning Society': The Challenge" by Ernest Bayles in which he calls for focus on learning to live, developing skills of reflection and judgment applicable to vital issues, and reflective teaching; 2) "Teacher Education in a Learning Society" in which David Turney demands teacher…

Science in the Information Society

CERN Document Server

2003-01-01

CERN will host the Role of Science in the Information Society (RSIS) conference on Monday and Tuesday, focusing on how science-driven information and communication technologies can help close the digital divide. There will be an army of bodyguards at CERN at the beginning of December. CERN will not only host the official visits, but also around 500 scientists, politicians, and members of civil society who will descend on the Main Auditorium for the Role of Science in the Information Society (RSIS) conference on 8-9 December. The RSIS conference hosted by CERN is a high-profile event focusing on how to make information technologies work for the greatest human benefit - a marked change from keeping a relatively low profile so far, making its discoveries available to all with little input in how they are applied. The RSIS, held 8-9 December at CERN, will be a Summit Event of the World Summit on the Information Society taking place at Palexpo on 9-13 December. RSIS participants will apply a scientific point of...

The use of HANDIDET{reg_sign} non-electric detonator assemblies to reduce blast-induced overpressure at AECL`s Underground Research Laboratory

Energy Technology Data Exchange (ETDEWEB)

Onagi, D.P.; Keith, S.G.; Kuzyk, G.W. [AECL, Pinawa, Manitoba (Canada). Underground Research Lab.; Proudfoot, D.F. [ICI Explosives Canada, North Delta, British Columbia (Canada)

1996-12-01

A number of aspects of the Canadian concept for nuclear fuel waste disposal are being assessed by Atomic Energy of Canada Limited (AECL) in a series of experiments at its Underground Research Laboratory (URL) near Lac du Bonnet, Manitoba, Canada. One of the major objectives of the work being carried out at the URL is to develop and evaluate the methods and technology to ensure safe, permanent disposal of Canada`s nuclear fuel waste. In 1994, AECL excavated access tunnels and a laboratory room for the Quarried Block Fracture Migration Experiment (QBFME) at the 240 Level of the URL. This facility will be used to study the transport of radionuclides in natural fractures in quarried blocks of granite under in-situ groundwater conditions. The experiment is being carried out under a cooperative agreement with the Japan Atomic Energy Research Institute. The excavation of the QBFME access tunnels and laboratory was carried out using controlled blasting techniques that minimized blast-induced overpressure which could have damaged or interrupted other ongoing experiments in the vicinity. The majority of the blasts used conventional long delay non-electric detonators but a number of blasts were carried out using HANDIDET 250/6000 non-electric long delay detonator assemblies and HTD{reg_sign} non-electric short delay trunkline detonator assemblies. The tunnel and laboratory excavation was monitored to determine the levels of blast-induced overpressure. This paper describes the blasting and monitoring results of the blasts using HANDIDET non-electric detonator assemblies and the effectiveness of these detonators in reducing blast-induced overpressure.

European Planning for an Information Society

DEFF Research Database (Denmark)

Henten, Anders; Skouby, Knud Erik; Falch, Morten

1996-01-01

Article analysing the different programmes and plans for the development of information societies in Europe.......Article analysing the different programmes and plans for the development of information societies in Europe....

The internationalization of the Korean radiological society

International Nuclear Information System (INIS)

Choi, Byung Ihn; Kim, Seung Hyup; Han, Man Chung; Kim, Young Goo; Kim, Kun Sang

1995-01-01

Toward the beginning of the twenty-first century, the world experiences the dramatic changes in politics, economics and culture, and it is evident that the Korean medical field will not be able to survive provided it doesn't prepare ourselves to adapt to those changes. The Korean Medical Society held a forum for the active operation of the medical society, inviting several leading affiliated societies, to meet the needs of the times. This review describes the summary of the presentation that the authors made on behalf of the Korean Radiological Society in the forum, including the organization, current status of academic activity, current status of international communication, and problems encountered in the internationalization of the Korean Radiological Society

Kosovar Society through Secularism and Religion

OpenAIRE

MSc. Dritero Arifi; Dr.Sc. Ylber Sela

2013-01-01

This paper will analyze the importance and the effects of religion, in Kosovar society. A great part of the paper, will analyze the social and the political relations in Post-War Kosovo. Initially it will elaborate religion and secularism, especially in theoreticall aspect, what impact have these definitions in modern societies. In order to explain what the importance of the religion in Kosovo is, we will focus on analyzing ethnical, social and political relations within Kosovo society. A...

The Kurdish Resurrection Society (1942-1945)

OpenAIRE

Sohrab Yazdani; Amir Sajjadi

2017-01-01

The Kurdish Resurrection Society (known as Komeley Jiyanewey Kurd) was the first political society that was founded after August and September 1941 and following the Anglo-Soviet Invasion of Iran. This society arose from traditional and modern strata of urban Kurdish petty bourgeois in Mahabad. The present study aims at discussing the following questions applying a descriptive-analytical approach and using the historical resources and studies: 1. What is the role of the new social and histori...

An Official American Thoracic Society/European Respiratory Society Statement: Key Concepts and Advances in Pulmonary Rehabilitation

NARCIS (Netherlands)

Spruit, Martijn A.; Singh, Sally J.; Garvey, Chris; ZuWallack, Richard; Nici, Linda; Rochester, Carolyn; Hill, Kylie; Holland, Anne E.; Lareau, Suzanne C.; Man, W.D.C.; Pitta, Fabio; Sewell, Louise; Raskin, Jonathan; Bourbeau, Jean; Crouch, Rebecca; Franssen, Frits M.E.; Casaburi, Richard; Vercoulen, Jan H.; Vogiatzit, Ioannis; Gosselink, Rik; Clini, Enrico M.; Effing, T.W.; Maltais, Francois; van der Palen, Jacobus Adrianus Maria; Troosters, Thierry; Janssen, Daisy J.A.; Collins, Eileen; Garcia-Aymerich, Judith; Brooks, Dina; Fahy, Bonnie F.; Puhan, Milo A.; Hoogendoorn, Martine; Garrod, Rachel; Schols, Annemie M.W.J.; Carlin, Brian; Benzo, Roberto; Meek, Paula; Morgan, Mike; Rutten-van Mölken, Maureen P.M.H.; Ries, Andrew L.; Make, Barry; Goldstein, Roger S.; Dowson, Claire A.; Brozek, Jan L.; Donner, Claudio F.; Wouters, Emiel F.M.

2013-01-01

Background: Pulmonary rehabilitation is recognized as a core component of the management of individuals with chronic respiratory disease. Since the 2006 American Thoracic Society (ATS)/European Respiratory Society (ERS) Statement on Pulmonary Rehabilitation, there has been considerable growth in our

Management of hemodynamically unstable pelvic trauma: results of the first Italian consensus conference (cooperative guidelines of the Italian Society of Surgery, the Italian Association of Hospital Surgeons, the Multi-specialist Italian Society of Young Surgeons, the Italian Society of Emergency Surgery and Trauma, the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care, the Italian Society of Orthopaedics and Traumatology, the Italian Society of Emergency Medicine, the Italian Society of Medical Radiology -Section of Vascular and Interventional Radiology- and the World Society of Emergency Surgery)

Science.gov (United States)

2014-01-01

Hemodynamically Unstable Pelvic Trauma is a major problem in blunt traumatic injury. No cosensus has been reached in literature on the optimal treatment of this condition. We present the results of the First Italian Consensus Conference on Pelvic Trauma which took place in Bergamo on April 13 2013. An extensive review of the literature has been undertaken by the Organizing Committee (OC) and forwarded to the Scientific Committee (SC) and the Panel (JP). Members of them were appointed by surgery, critical care, radiology, emergency medicine and orthopedics Italian and International societies: the Italian Society of Surgery, the Italian Association of Hospital Surgeons, the Multi-specialist Italian Society of Young Surgeons, the Italian Society of Emergency Surgery and Trauma, the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care, the Italian Society of Orthopaedics and Traumatology, the Italian Society of Emergency Medicine, the Italian Society of Medical Radiology, Section of Vascular and Interventional Radiology and the World Society of Emergency Surgery. From November 2012 to January 2013 the SC undertook the critical revision and prepared the presentation to the audience and the Panel on the day of the Conference. Then 3 recommendations were presented according to the 3 submitted questions. The Panel voted the recommendations after discussion and amendments with the audience. Later on a email debate took place until December 2013 to reach a unanimous consent. We present results on the 3 following questions: which hemodynamically unstable patient needs an extraperitoneal pelvic packing? Which hemodynamically unstable patient needs an external fixation? Which hemodynamically unstable patient needs emergent angiography? No longer angiography is considered the first therapeutic maneuver in such a patient. Preperitoneal pelvic packing and external fixation, preceded by pelvic binder have a pivotal role in the management of these patients

Images and society (or Images, Society and its Decoding

Directory of Open Access Journals (Sweden)

Juan Soto Ramírez

2012-11-01

Full Text Available Common sense, the thinking of the people par excellence, asserts that: a picture is worth a thousand words. This is a big mistake. The images are not carriers of meanings. The images always go through three basic processes are: production, circulation and reception. These processes are always determined in the time and social space. They are always the result of multiple relationships (social, ideological, political, moral, religious, etc., established with them. Always there are so many elements beyond the image, which determines its meaning. The meaning of an image always depends on the relationships established with it in a historical time and space, socially and culturally determined. The images are never alone. To decrypt their meanings, you must first know the symbolic life of the societies in which they appear. Images do not have a single meaning because it depends on the historical and cultural geography which presents. The images always have a close relationship with the society they were born. The Muhammad cartoons not offend everyone equally.

Politicized Civil Society in Bangladesh: Case Study Analyses

Directory of Open Access Journals (Sweden)

Farhat Tasnim

2017-03-01

Full Text Available Although civil society in Bangladesh is recognized for its vibrant performance in social development, it is often criticized for its inability to ensure good governance and democracy. The aim of this paper is to point out the reasons for this failure of civil society. Through performing case studies upon five civil society organizations representing different sector and level of the civil society, the paper concludes that civil society organizations in Bangladesh are often politicized and co-opted by different political parties. In a typical scenario, civil society can provide a counterbalance or even monitor the state both at the national and local level. However, in Bangladesh, often the civil society organizations have compromised their autonomy and politicized themselves to certain political parties or political block. In such a vulnerable position, civil society can hardly play its expected role to ensure good governance and strengthen democracy.

Social Value Orientation and Capitalism in Societies.

Science.gov (United States)

Shahrier, Shibly; Kotani, Koji; Kakinaka, Makoto

2016-01-01

Cooperation and competition are core issues in various fields, since they are claimed to affect the evolution of human societies and ecological organizations. A long-standing debate has existed on how social behaviors and preferences are shaped with culture. Considering the economic environment as part of culture, this study examines whether the ongoing modernization of competitive societies, called "capitalism," affects the evolution of people's social preferences and behaviors. To test this argument, we implemented field experiments of social value orientation and surveys with 1002 respondents for three different areas of Bangladesh: (i) rural, (ii) transitional and (iii) capitalistic societies. The main result reveals that with the evolution from rural to capitalistic societies, people are likely to be less prosocial and more likely to be competitive. In a transitional society, there is a considerable proportion of "unidentified" people, neither proself nor prosocial, implying the potential existence of unstable states during a transformation period from rural to capitalistic societies. We also find that people become more proself with increasing age, education and number of children. These results suggest that important environmental, climate change or sustainability problems, which require cooperation rather than competition, will pose more danger as societies become capitalistic.

American Geriatrics Society

Science.gov (United States)

... Learn More Social Media Facebook Twitter LinkedIn Instagram Social Media Bar Right Menu Annual Meeting Donate to our Foundation Contact Us American Geriatrics Society 40 Fulton St., 18th Floor New York, NY ...

High energy physics in our society

International Nuclear Information System (INIS)

Crozon, M.

1984-09-01

General survey of interactions between elementary particle physics and our society. The problem is studied for different aspects of our society: men and education, economics, technics, politics, international affairs, honours, myths.. [fr

Radiation protection and society

International Nuclear Information System (INIS)

Skryabin, A.M.

1997-01-01

The radiological protection of population, living on the contaminated territories, is actual 10 years after the Chernobyl accident. Eventually, the whole system of countermeasures application is aimed to protect society as a complex community of individuals . The variety of levels of society, i.e. family, settlement on the whole, can be considered as certain harmonic systems differing in their public consciousness levels and lifestyles, this explain the difference in their 'behaviour' in terms of radiation protection and attitude to the information obtained. Each level of society possesses a certain degree of liberty of choice, that finally influence the magnitude and the character of dose distribution within certain population groups. In general, the dose distribution in the settlement can be explained only on the bases of 'family' analysis. This concerns the rural settlement as a society too. All rural settlement can be divided into two or three classes: with low, high and intermediate social features. Small settlements (< 100 persons), where the advanced in age persons with low material income and high degree of natural economy are applied to the first class. This results in higher doses (2-3 fold), than in the settlements with higher social level. The analysis shows that in socially 'waning' settlements the countermeasures are less efficient and the term of their action is shorter. (this class is the largest, About 50% among all the rural settlements). Due to the deterioration of the economic situation in the Republic of Belarus after 1991-1992 resulted in the increase of doses mainly in the habitants first of all of this class of settlements. It seems problematic to increase countermeasures efficiency in this class of settlements without the refuse of the accustomed lifestyle and radical improvement of social-demographic and economic conditions. The present material shows the necessity of the differential approach based on 'society-analysis' in the

A Nineteenth Century Statistical Society that Abandoned Statistics

NARCIS (Netherlands)

Stamhuis, I.H.

2007-01-01

In 1857, a Statistical Society was founded in the Netherlands. Within this society, statistics was considered a systematic, quantitative, and qualitative description of society. In the course of time, the society attracted a wide and diverse membership, although the number of physicians on its rolls

American Epilepsy Society

Science.gov (United States)

... for the AES Annual Meeting. More info here . Epilepsy Currents American Epilepsy Society Journal Impact Factor More ... P450 enzyme overexpression during spontaneous recurrent seizures More Epilepsy Professional News AES Status Epilepticus guideline for treatment ...

Being, doing and leading in the project society

DEFF Research Database (Denmark)

Jensen, Anders; Geraldi, Joana; Thuesen, Christian

2017-01-01

explores strategies for living in the project society. Guided by the philosophical concepts of activity, time, space and relations, we explore the project society as an ideal type, in opposition to the disciplinary society. We discuss implications of being, doing and leading in a project society. Taken...

Education in the Information Society

Directory of Open Access Journals (Sweden)

Octavia-Luciana Porumbeanu

2007-01-01

Full Text Available This article approaches the fundamental role which education has in the information society. The continuous evolution of information and communication technologies requires that all citizens have the necessary skills have to use these technologies and to access information for efficient individual functioning in the information society. In this context, the information literacy programmes have a growing importance.

In vivo expansion of naïve CD4+ CD25(high FOXP3+ regulatory T cells in patients with colorectal carcinoma after IL-2 administration.

Directory of Open Access Journals (Sweden)

Marc Beyer

Full Text Available Regulatory T cells (T(reg cells are increased in context of malignancies and their expansion can be correlated with higher disease burden and decreased survival. Initially, interleukin 2 (IL-2 has been used as T-cell growth factor in clinical vaccination trials. In murine models, however, a role of IL-2 in development, differentiation, homeostasis, and function of T(reg cells was established. In IL-2 treated cancer patients a further T(reg-cell expansion was described, yet, the mechanism of expansion is still elusive. Here we report that functional T(reg cells of a naïve phenotype--as determined by CCR7 and CD45RA expression--are significantly expanded in colorectal cancer patients. Treatment of 15 UICC stage IV colorectal cancer patients with IL-2 in a phase I/II peptide vaccination trial further enlarges the already increased naïve T(reg-cell pool. Higher frequencies of T-cell receptor excision circles in naïve T(reg cells indicate IL-2 dependent thymic generation of naïve T(reg cells as a mechanism leading to increased frequencies of T(reg cells post IL-2 treatment in cancer patients. This finding could be confirmed in naïve murine T(reg cells after IL-2 administration. These results point to a more complex regulation of T(reg cells in context of IL-2 administration. Future strategies therefore might aim at combining IL-2 therapy with novel strategies to circumvent expansion and differentiation of naïve T(reg cells.

TRANSFORMATION OF FAMILY IN MODERN RUSSIAN SOCIETY

Directory of Open Access Journals (Sweden)

Olga Anatolevna Otradnova

2014-09-01

Full Text Available The article examines concept of family in Russian society, changes in interpretation of family, connected with modern tendencies and processes in different sociocultural spheres.   The article is structured and has accurate limits of introduction, main part and conclusion. The relevance of the research is caused by present-day crisis tendencies connected with suicide actions, atomization and hedonization of society, value depreciation of family.  The object of the research is to analyze the conception of family and its transformation in condition of modern Russian society. The tasks are to determine the term family, to analyze approaches to understanding of the family and its genesis, detect some peculiarities of modern Russian society, research the transformation of interpretation of family in modern society; the matter of investigation is modern Russian society, the subject is the transformation of family structures; the following methods of research are used: historical and cultural approach, typological method, existential method, common logic procedures. The research contains author’s definition of the term family, historical and cultural analysis and typological explication of the approaches to interpretation of the problem, classification of family structures - which have been formed in Russian society- on the base of statistic and sociological data.   Some interweaving of concept family with the most important existential values (love, freedom, responsibility were investigated and some tendencies for further development of family relationship in Russian society were revealed, its problems and prospect were emphasized. The results of the investigation testify that modern types of matrimonial relationship differ in limitation of functionality, mutual responsibility, thereby it is possible to state that interpretation of family in modern Russian society has transformed.

The new totalitarian society

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Vlajki Emil

2011-01-01

Full Text Available The new totalitarian society is a euphemized expression denoting the New World Order, which in itself denotes the American globalization. The underpinning of this mindset is rationality, which is characteristic of Western civilization. Christianity engendered rationality by introducing it through St. Thomas Aquinas, Aristotle, and especially formal logic. Since it is obvious that religion and logic cannot ultimately be harmonized, this combination has proven lethal in many cases throughout history. For instance, the Inquisition, which, contrary to what happened at scholastic universities, severely berated rational thinking in practice. Catholicism helped carry out genocide against the Jews, and Orthodoxy is in a certain manner tied in with Stalinism. The new totalitarian society is anchored in American Protestantism. On the whole, Christian rationalism is a sphere of science, techniques and technologies efficiently employed to promote the West to the status of a society of plenty and the conception of human rights, which turn into their opposite and irrational behavior of the worst kind. An example of such inhumanity is the attack against Yugoslavia/Serbia in 1999.

Consumers, Nanotechnology and Responsibilities Operationalizing the Risk Society.

NARCIS (Netherlands)

Throne-Holst, H.

2012-01-01

Risks are high on the agenda in our society, to the extent that we might refer to the society as a risk society. Our society experiences emerging technologies, like nanotechnology. Different actors respond to this in a variety of ways. Among these are the consumers, an important, but neglected

The Impact of Civil Society Organizations on Sustainable ...

African Journals Online (AJOL)

Civil society groups are agents of development in any nation. Civil society organizations appear to play important role in social, political and economic development activities. The transformation of any society or system, particularly the developing societies like Nigeria depend on the effectiveness and efficiency of its civil ...

Registration of four post-flowering drought tolerant grain sorghum lines with early season cold tolerance

Science.gov (United States)

Four sorghum (Sorghum bicolor L.) germplasm lines— PSLS-SGCTB01 (Reg. No.), PSLS-SGCTR02 (Reg. No.), PSLS-SGCTB03 (Reg. No.) and PSLS-SGCTB04 (Reg. No.) — were developed by the USDA-ARS in Lubbock TX, in 2017. The primary purpose for the release of these lines is to provide an alternative germplasm ...

DOES CIVIL SOCIETY CREATE SOCIAL ENTREPRENEURS?

OpenAIRE

Gauca Oana; Hadad Shahrazad

2013-01-01

The purpose of this paper is to analyze whether civil society itself can enhance or stimulate the creation of social entrepreneurs, by studying the traits of the civil society and the various definitions attributed to it. The main question that the paper wants to answer to is and the main approach used in this research paper is the theoretical one. By studying existing articles and books on the topic, the paper tries to emphasize the various dimensions that civil society can embrace, as pictu...

Social Value Orientation and Capitalism in Societies

Science.gov (United States)

Shahrier, Shibly; Kakinaka, Makoto

2016-01-01

Cooperation and competition are core issues in various fields, since they are claimed to affect the evolution of human societies and ecological organizations. A long-standing debate has existed on how social behaviors and preferences are shaped with culture. Considering the economic environment as part of culture, this study examines whether the ongoing modernization of competitive societies, called “capitalism,” affects the evolution of people’s social preferences and behaviors. To test this argument, we implemented field experiments of social value orientation and surveys with 1002 respondents for three different areas of Bangladesh: (i) rural, (ii) transitional and (iii) capitalistic societies. The main result reveals that with the evolution from rural to capitalistic societies, people are likely to be less prosocial and more likely to be competitive. In a transitional society, there is a considerable proportion of “unidentified” people, neither proself nor prosocial, implying the potential existence of unstable states during a transformation period from rural to capitalistic societies. We also find that people become more proself with increasing age, education and number of children. These results suggest that important environmental, climate change or sustainability problems, which require cooperation rather than competition, will pose more danger as societies become capitalistic. PMID:27792756

Social Value Orientation and Capitalism in Societies.

Directory of Open Access Journals (Sweden)

Shibly Shahrier

Full Text Available Cooperation and competition are core issues in various fields, since they are claimed to affect the evolution of human societies and ecological organizations. A long-standing debate has existed on how social behaviors and preferences are shaped with culture. Considering the economic environment as part of culture, this study examines whether the ongoing modernization of competitive societies, called "capitalism," affects the evolution of people's social preferences and behaviors. To test this argument, we implemented field experiments of social value orientation and surveys with 1002 respondents for three different areas of Bangladesh: (i rural, (ii transitional and (iii capitalistic societies. The main result reveals that with the evolution from rural to capitalistic societies, people are likely to be less prosocial and more likely to be competitive. In a transitional society, there is a considerable proportion of "unidentified" people, neither proself nor prosocial, implying the potential existence of unstable states during a transformation period from rural to capitalistic societies. We also find that people become more proself with increasing age, education and number of children. These results suggest that important environmental, climate change or sustainability problems, which require cooperation rather than competition, will pose more danger as societies become capitalistic.

Simulation of bulk aerosol direct radiative effects and its climatic feedbacks in South Africa using RegCM4

Science.gov (United States)

Tesfaye, M.; Botai, J.; Sivakumar, V.; Mengistu Tsidu, G.; Rautenbach, C. J. deW.; Moja, Shadung J.

2016-05-01

In this study, 12 year runs of the Regional Climate Model (RegCM4) have been used to analyze the bulk aerosol radiative effects and its climatic feedbacks in South Africa. Due to the geographical locations where the aerosol potential source regions are situated and the regional dynamics, the South African aerosol spatial-distribution has a unique feature. Across the west and southwest areas, desert dust particles are dominant. However, sulfate and carbonaceous aerosols are primarily distributed over the east and northern regions of the country. Analysis of the Radiative Effects (RE) shows that in South Africa the bulk aerosols play a role in reducing the net radiation absorbed by the surface via enhancing the net radiative heating in the atmosphere. Hence, across all seasons, the bulk aerosol-radiation-climate interaction induced statistically significant positive feedback on the net atmospheric heating rate. Over the western and central parts of South Africa, the overall radiative feedbacks of bulk aerosol predominantly induces statistically significant Cloud Cover (CC) enhancements. Whereas, over the east and southeast coastal areas, it induces minimum reductions in CC. The CC enhancement and RE of aerosols jointly induce radiative cooling at the surface which in turn results in the reduction of Surface Temperature (ST: up to -1 K) and Surface Sensible Heat Flux (SSHF: up to -24 W/m2). The ST and SSHF decreases cause a weakening of the convectively driven turbulences and surface buoyancy fluxes which lead to the reduction of the boundary layer height, surface pressure enhancement and dynamical changes. Throughout the year, the maximum values of direct and semi-direct effects of bulk aerosol were found in areas of South Africa which are dominated by desert dust particles. This signals the need for a strategic regional plan on how to reduce the dust production and monitoring of the dust dispersion as well as it initiate the need of further research on different

The Dialectic of the Nature-Society-System

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Christian Fuchs

2008-07-01

Full Text Available There are four logical possibilities for conceiving the relationship of nature and society: the reduction of society to nature, the projection of nature into society, dualism, and a nature-society-dialectic. This differentiation results in four different approaches. Nature is a self-organizing system that produces an evolutionary hierarchy of interconnected systems with specific qualities. Society is a product of nature where humans produce and reproduce structures that enable and constrain human practices in dynamic processes. Parts of nature are observed and appropriated by humans from within society, these parts are socially constructed and form a subsystem of society. The self-organization cycle of nature and the self-organization cycle of the socio-sphere are mutually connected in a productive cycle of society where natural self-organization serves as the material foundation that enables and constrains social self-organization and human production processes transform natural structures and incorporate these very structures into society as means of production (technologies, raw materials. The economy is that part of the socio-sphere where the relationship between nature and the socio-sphere is established, the mediation is achieved by human labour processes. Nature enters the economic process as material input in the form of means of production (constant capital: machines, raw materials, auxiliary materials. Organized nature that is part of the production process in the form of technology increases the productivity of labour and hence reduces the costs of variable capital (total amount of wages and increases the speed of the production of surplus value. The production system of modern society is oriented on economic profit and productivity, ecological depletion and pollution are by-products of modernization. The Fordist production model that originated in the West and was copied by the Soviet Union is one of the major causes of the global

Signal peptide cleavage is essential for surface expression of a regulatory T cell surface protein, leucine rich repeat containing 32 (LRRC32).

Science.gov (United States)

Chan, Derek V; Somani, Ally-Khan; Young, Andrew B; Massari, Jessica V; Ohtola, Jennifer; Sugiyama, Hideaki; Garaczi, Edina; Babineau, Denise; Cooper, Kevin D; McCormick, Thomas S

2011-05-26

Elevated numbers of regulatory T cells (T(regs)) have been implicated in certain cancers. Depletion of T(regs) has been shown to increase anti-tumor immunity. T(regs) also play a critical role in the suppression of autoimmune responses. The study of T(regs) has been hampered by a lack of adequate surface markers. Leucine Rich Repeat Containing 32 (LRRC32), also known as Glycoprotein A Repetitions Predominant (GARP), has been postulated as a novel surface marker of activated T(regs). However, there is limited information regarding the processing of LRRC32 or the regulatory phenotype and functional activity of T(regs) expressing LRRC32. Using naturally-occurring freshly isolated T(regs), we demonstrate that low levels of LRRC32 are present intracellularly prior to activation and that freshly isolated LRRC32+ T(regs) are distinct from LRRC32- T(regs) with respect to the expression of surface CD62L. Using LRRC32 transfectants of HEK cells, we demonstrate that the N-terminus of LRRC32 is cleaved prior to expression of the protein at the cell surface. Furthermore, we demonstrate using a construct containing a deleted putative signal peptide region that the presence of a signal peptide region is critical to cell surface expression of LRRC32. Finally, mixed lymphocyte assays demonstrate that LRRC32+ T(regs) are more potent suppressors than LRRC32- T(regs). A cleaved signal peptide site in LRRC32 is necessary for surface localization of native LRRC32 following activation of naturally-occurring freshly-isolated regulatory T cells. LRRC32 expression appears to alter the surface expression of activation markers of T cells such as CD62L. LRRC32 surface expression may be useful as a marker that selects for more potent T(reg) populations. In summary, understanding the processing and expression of LRRC32 may provide insight into the mechanism of action of T(regs) and the refinement of immunotherapeutic strategies aimed at targeting these cells.

50-year-old history of the Korean physical society

International Nuclear Information System (INIS)

2002-12-01

This book introduces the root of Korean physics, the dawning of Korean physics, foundation and childhood of Korean physics society, growth of Korean physics society, revival of Korean physics society, corporation Korean physics society, leap of Korean physics society and challenges towards future. It also deals with 50-year-old history of the Korean physical society according to committees, special interest groups, branches in cities and provinces, branches in universities, laboratories, society bureau, and commemoration business to celebrate 50th anniversary.

Older people in the information society

Directory of Open Access Journals (Sweden)

Aleksandra Marcinkiewicz-Wilk

2016-06-01

Full Text Available This paper focuses on the situation of older people in the information society. In the theoretical part of article phenomena of aging population and information society were described. This paper includes results of research conducted in qualitative strategy. The method of collecting data was biographical method. The method for data processing was qualitative content analysis. In the research 2 older, educationally active people took part. Results of research shows how older people understand the information society and what risk and opportunities they notice in this new reality. Narratives of the respondents indicated that education is of crucial importance for participation in the information society. Older people who take part in lifelong learning cope better with the new reality than people who do not learn. Based on the research results we can point out areas of education which should be development. Moreover, it is visible that educational activity of older people is very important in adaptation to the information society. Narratives of seniors indicate reasons for the lack of educational activity of other seniors. According to this, it can be specified what action should be undertaken to prevent the exclusion of older people in this new reality

Two faces of global open society

Directory of Open Access Journals (Sweden)

Cvetićanin Neven

2008-01-01

Full Text Available The Essay considers 'the rule' of the so called post-civil political centre that corresponds to the familiar concept of open society, questioning the good as well as the bad sides of such 'rule'. The research is in the first place about global open society stability and attention is addressed to its present enemies - from terrorism, over organized crime, all the way to the so called local legitimates that are confronting the universal and global legitimates represented by the followers of the open society from the post civil political centre area. The Essay presents the debate with Fukuyama's thesis about the 'end of history' considering that open society, i.e. global post civil political centre has visible enemies who do not allow for dialectics of history to stand still as Fukuyama believed. Instead of Fukuyama's 'end of history' the Essay comes to the conclusion that present global situation is marked by post-modern opposition of liberal-democratic post civil centre and extreme anti civil margins, with reference to the opposition of open society and its enemies, which will put under limits further steps of history towards new socio-historical forms.

Joint annual meeting of the Swiss Physical and the Society Austrian Physical Society

CERN Document Server

2017-01-01

The next annual meeting, hosted by CERN, will take place from 21 - 25 August 2017 in Genève at two different locations. Starting at CERN on 21st with internal meetings of some of the participating societies, the 22nd will be dedicated to plenary and invited talks and more (see below). We will then move to the Centre International de Conférences de Genève (CICG) on 23 - 25 August where further plenary talks and all topical sessions will take place. The meeting is organised - as every two years - as a joint meeting with the Austrian Physical Society (ÖPG) and the Swiss Society for Astrophysics and Astronomy (SSAA). The Swiss Institute of Particle Physics (CHIPP) will participate additionally to their usual 2-year rhythm. We also welcome for the first time the NCCR MARVEL (Computational Design and Discovery of Novel Materials). They all together guarantee an exciting conference covering physics at its best. Many thanks go to CERN for their generous help and support with the organisation.

THE COPYRIGHT IN THE INFORMATION SOCIETY

Directory of Open Access Journals (Sweden)

Cristinel Ioan MURZEA

2016-06-01

Full Text Available The contemporary society has imposed new demands in the development and application of copyright as a result of structural changes which occur as a result of developments in science, technology and especially communication technologies and of informatics. Legal doctrine highlights axiomatic truth according to which the “environment created by technological developments” brings forward the profound informational dimension of human being in the contemporary society. In this context the integration and the harmonization of legislation of the Member States of the European Union leads to a complex and dynamic process by which the copyright called to legally protect intellectual creation in contemporary society, acquires a universal vocation in the contemporary society, because there are no barriers or impediments in its spreading especially due to the phenomenon of multiplication and improvement of means of information and communication

Facebook: Networking the Community of Society

DEFF Research Database (Denmark)

Tække, Jesper

The article examines the significance of new "social media" like Facebook for the way we socialize, develop social identity, and shape society. Based on the work of Luhmann, the article proposes that community communication is fundamental to the selfregulation of our society and that this type...... but that also may pose certain risks for modern society and for the development and maintenance of social identity. The article argues that communication through and about status updates on Facebook may be categorized as network communication, and finally it discusses whether and to what extent this kind...... of communication also provides the basis for the formation and maintenance of people’s social identity, so that they and society are in harmony. In contrast to community communication, the article explores the notion of network communication, which is classified as communication that may have some positive effects...

Registration of cytoplasmic male-sterile oilseed sunflower genetic stocks CMS GIG2 and CMS GIG2-RV, and fertility restoration lines RF GIG2-MAX 1631 and RF GIG2-MAX 1631-RV

Science.gov (United States)

Two cytoplasmic male-sterile (CMS) oilseed sunflower (Helianthus annuus L.) genetic stocks, CMS GIG2 (Reg. No. xxx, PI xxxx), and CMS GIG2-RV (Reg. No. xxx, PI xxxx), and corresponding fertility restoration lines RF GIG2-MAX 1631 (Reg. No. xxx, PI xxxx) and RF GIG2-MAX 1631-RV (Reg. No. xxx, PI xxx...

Grondwetlike waardes, openbare administrasie en die reg op toegang tot omgewingsinligting

Directory of Open Access Journals (Sweden)

A. Ferreira-Snyman

2002-08-01

Full Text Available Constitutional values, public administration and the right of access to environmental information During the previous constitutional dispensation in South Africa the management of information tended to be excessively secretive. This position was changed by section 32 of the Constitution of the Republic of South Africa, 1996. According to the 1996 Constitution South Africa is a sovereign, democratic state founded on certain values such as human dignity, freedom and equality. The public administration is governed by democratic values and principles such as transparency. In this article the constitutional values and principles that underlie an open and democratic society are discussed. Thereafter the right of access to information and the legislation that gives content to this right are analysed. It is concluded that the right of access to information can provide opportunities to the public sector, the private sector and the general public to form partnerships in sharing environmental information in order to fulfil their constitutional obligations.

2010 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Training Standards and Maintenance of Competency in Adult Clinical Cardiac Electrophysiology.

Science.gov (United States)

Green, Martin S; Guerra, Peter G; Krahn, Andrew D

2011-01-01

The last guidelines on training for adult cardiac electrophysiology (EP) were published by the Canadian Cardiovascular Society in 1996. Since then, substantial changes in the knowledge and practice of EP have mandated a review of the previous guidelines by the Canadian Heart Rhythm Society, an affiliate of the Canadian Cardiovascular Society. Novel tools and techniques also now allow electrophysiologists to map and ablate increasingly complex arrhythmias previously managed with pharmacologic or device therapy. Furthermore, no formal attempt had previously been made to standardize EP training across the country. The 2010 Canadian Cardiovascular Society/Canadian Heart Rhythm Society Training Standards and Maintenance of Competency in Adult Clinical Cardiac Electrophysiology represent a consensus arrived at by panel members from both societies, as well as EP program directors across Canada and other select contributors. In describing program requirements, the technical and cognitive skills that must be acquired to meet training standards, as well as the minimum number of procedures needed in order to acquire these skills, the new guidelines provide EP program directors and committee members with a template to develop an appropriate curriculum for EP training for cardiology fellows here in Canada. Copyright © 2011 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

Features of social modernization of Kazakhstan society

OpenAIRE

Southbaeva S.

2017-01-01

The analysis of social modernization of the Kazakhstan society is carried out. The article provides information on sociological analysis, analysis of normative legal acts aimed at improving the social modernization of Kazakhstan society. The level of legal culture and spiritual and moral values of the Kazakh society are singled out. Further development prospects for improving social modernization are given.

Civil Society, Democratic Space, and Social Work

Directory of Open Access Journals (Sweden)

Neelmani Jaysawal

2013-10-01

Full Text Available Civil Society envisages the growth of civilization in a way that the society is in “civilized form.” It has been prominent in Social science since time immemorial. Till 18th century, it was synonymous with the state or political society. It was more or less direct translation of Cicero’s Societas’ Civilis and Aristotle’s Koinonia politike. According to Karl Marx, “Civil Society embraces the whole material intercourse of individuals within a definite stage of development of productive forces.” Civil Society is an arena where modern man legitimately gratifies his self-interest and develops his individuality, but also learns the value of group action, social solidarity which educates him for citizenship and equips him to participate in the political sphere of the state. It provides “networks of civic engagement” within which reciprocity is learned and enforced, trust is generated. An active and diverse civil society plays a valuable role in advancement of democracy. It seeks to ensure that citizen’s interests are taken seriously. The social work intervention may not be democratically envisaged until it is promulgated by civic engagement through Civil Society. Methodology: This is a descriptive study which consists of secondary source of data collection based on reports, books, periodic journals, web-based articles. There have been utilized three case studies for reaching the findings of study. This article will highlight on role of civil society in providing democratic space and assisting social workers to ensure inclusive growth through conglomeration of state and individuals.

MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis

International Nuclear Information System (INIS)

Mirlekar, Bhalchandra; Patil, Sachin; Bopanna, Ramanamurthy; Chattopadhyay, Samit

2015-01-01

T reg cells are not only crucial for controlling immune responses to autoantigens but also prevent those directed towards commensal pathogens. Control of effector immune responses by T reg cells depend on their capacity to accumulate at inflammatory site and accordingly accommodate to inflammatory environment. Till date, the factors associated with maintaining these aspects of T reg phenotype is not understood properly. Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic T reg cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. Elimination of anti-inflammatory subsets revealed a protective role for IL-10 producing T reg cells in SMAR1 −/− mice. Moreover, a combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic T reg cells that controls acute colitis. This data highlights a critical role of SMAR1 in maintaining T reg physiology during inflammatory disorders. - Highlights: • SMAR1 is essential to sustain high level of Foxp3 and IL-10 in T reg cells. • SMAR1 −/− T reg cells produce pro-inflammatory cytokine IL-17 leads to inflammation. • IL-10 administration can control the inflammation in SMAR1 −/− mice. • Both Foxp3 and SMAR1 maintain T reg phenotype that controls colitis

[History of the Strasbourg Society of Biology].

Science.gov (United States)

Antony, Pierre; Romier, Christophe; Mantz, Jean-Marie

2017-01-01

The Society of Biology of Strasbourg (SBS) is a learned society that was created in 1919 based on the model of the Society of Biology of which it is a subsidiary. Like its Parisian colleague, SBS aims at diffusing and promoting scientific knowledge in biology. To achieve this goal, SBS initiated since its creation a dialogue interface between researchers in biology and physicians, and more recently with other scientific disciplines, industry and the civil society. At the dawn of its first century, the Society of Biology of Strasbourg must continue to reinvent itself to pursue its development and to fulfil its mission of sharing scientific knowledge. This work continues in strong collaboration with our partners that share with SBS the willingness to foster excellence in biological research in Strasbourg, its region and beyond. © Société de Biologie, 2017.

Civil Society, Health, and Social Exclusion in Bangladesh

Science.gov (United States)

Mahmud, Simeen

2009-01-01

Civil society has the potential to have a positive impact on social exclusion and health equity through active monitoring and increased accountability. This paper examines the role of civil society in Bangladesh to understand why this potential has not been realized. Looking at two models of civil society action—participation in decentralized public-sector service provision and academic think-tank data analysis—this analysis examines the barriers to positive civil society input into public policy decision-making. The role of non-governmental organizations, political, cultural and economic factors, and the influence of foreign bilateral and multilateral donors are considered. The paper concludes that, with a few exceptions, civil society in Bangladesh replicates the structural inequalities of society at large. PMID:19761087

Change of values in the consumer society

Directory of Open Access Journals (Sweden)

Austruma S.

2012-10-01

Full Text Available A common feature of our age is orientation of young people towards transitional values. Economic partnership of consumer society has a direct impact on values of society and even if the process of change of values can be affected by formers of education politics, economists and politicians, young people still choose values, which conform with their own lifestyle. Content of educational subjects is connected with study, succession of cultural values, study of classified knowledge and skills, which is also a prerequisite of formation of personality. Societies of all ages has formed according to the specific mechanism, accumulating and integrating general, notable at that time ideas, preserving and transforming their own social experience to the next generations. Each culture declares itself from its scale of values and norms. Priority of change of post material and material values changes together with conditions of cultural, historical and social-political life. Change of paradigms is change of viewpoint of the world, therefore conditions of value choice relate not only to separate groups, but to whole cultures. Young people, similar to other members of society, are forced to construct their own identity and to form their own life insurance strategies offered by the consumer society. Consumer society forms its values and it is creator of its own significance, but young people as social agents are reproducers of values of consumer society. Research results of World Value Surveys (WVS from six continents discovered big differences in value priorities between younger and older generations, which indicates not only inter-generation value change, but also changes in the whole society. The research “Value choice of young people in consumer society” in our country shows, that although the lifestyle of young people is pragmatic, traditional value – family is also one of the most often mentioned and important values in consumer society. But

Rationality in Society

NARCIS (Netherlands)

Flache, Andreas; Dijkstra, Jacob; Wright, James D.

2015-01-01

Contemporary theories of rational behavior in human society augment the orthodox model of rationality both by adding various forms of bounded rationality and relaxing the assumptions of self-interest and materialistic preferences. This entry discusses how these extensions of the theory of rational

History of Japanese Society of Toxicology.

Science.gov (United States)

Satoh, Tetsuo

2016-01-01

Founded in 1981, the Japanese Society of Toxicology (JSOT) has grown into an organization of nearly 3,000 members working together to advance the nation's scientific knowledge and understanding of toxicology through the implementation of planning that ensures a systematic and efficient expenditure of energies and resources, and is closely aligned with a strategy for accomplishing the Society's long-range plans. To promote public education in toxicology, the Society organizes public lectures during each year's annual meeting. Other activities include hosting scientific conferences, promoting continuing education, and facilitating international collaboration. Internally, the JSOT operates five standing committees: General Affairs, Educational, Editorial, Finance, and Science and Publicity to handle its necessary relationships. To bestow official recognition, the Society established its Toxicologist Certification Program in 1997, and has certified 536 members as Diplomat Toxicologists (DJSOT) as of May 1, 2016. Furthermore, on the same date, 43 JSOT members were certified as Emeritus Diplomats of the JSOT (EDJSOT). The Society has launched two official journals, the "Journal of Toxicological Sciences (JTS)" in 1981 and "Fundamental Toxicological Sciences (Fundam. Toxicol. Sci.)" in 2014. As for participation in the international organizations, the JSOT (then known as the Toxicological Research Group) joined the International Union of Toxicology as a charter member in 1980, and became a founding member of the Asian Society of Toxicology at its inauguration in 1994. Into the future, the JSOT will continue working diligently to advance knowledge and understanding of toxicology and secure its place among the interdisciplinary fields of science, humane studies, and ethics.

Internal Conflicts in Muslim Societies

Directory of Open Access Journals (Sweden)

Ashiq Ali Shah

2001-12-01

Full Text Available An analysis of psychological theories and the social dynamics of the society help identify salient attributes and processes relevant to conflict among Muslims. The psychodynamic concept of personality and frustration-aggression hypothesis account for the socialization practices in the Muslim societies, emotional instability, unfavorable evaluation of those holding a different viewpoint and venting out one's aggression on the weaker. The tendency of the Muslims to praise their sect/tribe/religious group leads to a groupthink situation that polarizes intergroup relationships. The acts of categorization in group and out group, as postulated by the social identity theory, contribute towards the distorted perception of each other. The Islamic notions of brotherhood, unity and ethnic identity as means of personal identification and social interaction seems to have been forgotten by the Muslims. Though the Western social-psychological constructs are helpful in understanding the causes of conflict among Muslims, they are not germane to Muslim societies. The group belongingness and group favouritism is not necessarily a tool of discrimination and conflict but is an essential component of one's survival in a collectivist society. The Western theories also do not address the economic and political circumstances responsible for the multitude of conflicts among Muslims.

Civil society in a divided society: Linking legitimacy and ethnicness of civil society organizations in Bosnia-Herzegovina.

Science.gov (United States)

Puljek-Shank, Randall; Verkoren, Willemijn

2017-06-01

Civil society (CS) strengthening is central to peacebuilding policies for divided, post-war societies. However, it has been criticized for creating internationalized organizations without local backing, unable to represent citizens' interests. Based on in-depth empirical research in Bosnia-Herzegovina, this article focuses on the legitimacy of CS organizations (CSOs). It explores why legitimacy for donors rarely accompanies legitimacy for local actors. We hypothesized that whilst donors avoid supporting mono-ethnic organizations, seen as problematic for peacebuilding, 'ethnicness' may provide local legitimacy. However, our analysis of CSOs' ethnicness nuances research characterizing organizations as either inclusive or divisive. Moreover, local legitimacy is not based on ethnicness per se, but CSOs' ability to skilfully interact with ethnically divided constituencies and political structures. In addition, we offer novel explanations why few organizations enjoy both donor and local legitimacy, including local mistrust of donors' normative frameworks and perceived lack of results. However, we also show that a combination of local and donor legitimacy is possible, and explore this rare but interesting category of organizations.

The School, The Scholar, And Society.

Science.gov (United States)

Wilson, O. Meredith

Traditionally, universities have independently sought and preserved knowledge and prepared students for professional careers, although society has influenced and supported their objectives. Today's universities, challenged by the increasingly complex needs of society, are responding with educational innovations that are usually profitable to both.…

Science and Society Colloquium

CERN Multimedia

Randi, J

1991-01-01

Mr. Randi will give an update of his lecture to the American Physical Society on the occasion of his award of the 1989 Forum Prize. The citation said: "for his unique defense of Science and the scientific method in many disciplines, including physics, against pseudoscience, frauds and charlatans. His use of scientific techniques has contributed to refuting suspicious and fraudulent claims of paranormal results. He has contributed significantly to public understanding of important issues where science and society interact". He is a professional magician and author of many books. He worked with John Maddox, the Editor of Nature to investigate the claims of "water with memory".

Advanced information society(7)

Science.gov (United States)

Chiba, Toshihiro

Various threats are hiding in advanced informationalized society. As we see car accident problems in motorization society light aspects necessarily accompy shady ones. Under the changing circumstances of advanced informationalization added values of information has become much higher. It causes computer crime, hacker, computer virus to come to the surface. In addition it can be said that infringement of intellectual property and privacy are threats brought by advanced information. Against these threats legal, institutional and insurance measures have been progressed, and newly security industry has been established. However, they are not adequate individually or totally. The future vision should be clarified, and countermeasures according to the visions have to be considered.

Following the results of the EMPA-REG OUTCOME trial with empagliflozin, is it possible to speak of a class effect?

Directory of Open Access Journals (Sweden)

Ampudia-Blasco FJ

2017-01-01

Full Text Available Francisco Javier Ampudia‑Blasco,1 Irene Romera,2 Bernat Ariño,3 Ramón Gomis4 1Endocrinology and Nutrition Department, Clinic University Hospital Valencia, Valencia, Spain; 2Eli Lilly and Company España, Madrid, Spain; 3Boehringer Ingelheim España, Barcelona, Spain; 4Endocrinology Department, Hospital Clinic Barcelona, Barcelona, Spain Background: The recently published cardiovascular outcomes data for the first sodium–glucose cotransporter 2 (SGLT2 inhibitor, empagliflozin, have shown cardiovascular safety and additional benefits in patients with type 2 diabetes and established cardiovascular disease. Empagliflozin showed lower rates of death from cardiovascular causes or from any causes and lower hospitalization rates from heart failure compared with placebo, both in addition to standard care. This commentary discusses the existence of a possible class effect considering the available evidence described for other SGLT2 inhibitors. Main text: Empagliflozin, dapagliflozin and canagliflozin share the same mechanism of action, and it is a plausible hypothesis that some of the benefits of empagliflozin treatment could also be expected from other SGLT2 inhibitors. However, the rapid and persistent occurrence of cardiovascular benefits observed with empagliflozin and the different results shown by the three inhibitors in meta-analyses of some of their respective Phase II and III trials might suggest another possible mechanism of action, perhaps related to the different selectivity to inhibit SGLT-2 and other SGLT family members that these compounds present. Conclusion: There is still lack of evidence to answer whether the cardiovascular benefits observed with empagliflozin in the EMPA-REG OUTCOME study could be seen as a “class effect”, which is also attributable to dapagliflozin and canagliflozin. Keywords: cardiovascular, outcome studies, SGLT2 inhibitors, empagliflozin, dapagliflozin, canagliflozin

Nuclear Society and non-proliferation problems

International Nuclear Information System (INIS)

Gagarinskij, A.Ya.; Kushnarev, S.V.; Ponomarev-Stepnoj, N.N.; Sukhoruchkin, V.K.; Khromov, V.V.; Shmelev, V.M.

1997-01-01

In the USSR Nuclear Society in 1991 the special working group on the problems of nuclear weapons non-proliferation and nuclear materials control, uniting the experts of different types (nuclear physicists, lawyers, teachers), was created. This group became the mechanism of the practical Nuclear Society activity realization in this sphere. Three milestones of the innovative activity can be specified. First Milestone. In January 1992 the Central Nuclear Society Board (of the International Public Nuclear Society Association) published a special appeal to the First Leaders of all countries - former USSR republics. This address paid a special attention to the unity of the USSR power-industrial complex, and numerous problems arisen while separating this complex, including nuclear weapons non-proliferation problems, were indicated as well. Second Milestone. In 1992 and 1993 the Nuclear Society experts issued two selection 'Nuclear Non-proliferation and Control Problems' including reviewing basic papers. In addition, materials on non-proliferation and control are published regularly in the organs. Third Milestone.In 1993 - 1997 some special scientific and technical events (conferences, workshops, meetings) allowing to analyze the joint international projects and contracts outcomes, and establish new contacts between the specialists of NIS, Baltic states and others, have been hold

Empowering the society through companies CSR agenda

Directory of Open Access Journals (Sweden)

Sulaiman Noor Adwa

2017-01-01

Full Text Available Topic of socioeconomic issue is one of the most widely discussed globally as it gives effects to occupation, education, income, wealth, and place of residence of individuals. These social challenges should be addressed and resolved because to enhance individuals’ contribution to economic and social life of their society and reduce social tensions and conflicts that negatively affects country’s economic development. For this reason, in the Eleventh Malaysia Plan (2016-2020, the Malaysian Government stresses on the importance of participation of companies in empowering society to improve socioeconomic that could support equitable society. The empowerment programs aim to improve the education, quality of life and wellbeing of individuals and groups in society through reducing wealth gap, racial imbalance and promoting employment equity. One way to initiate greater involvement of the companies in socioeconomic development of the society is through CSR agenda. Specifically, the CSR agenda through empowerment activities (such as trainings programs, educational sponsorship mentorship program and learning and development programs is believed to have a positive implication on society by way of improving wealth, education and skills of the individuals. Hence, this paper aims to develop measurement of empowerment in companies CSR agenda.

Maintaining Life-saving Testing for Patients With Infectious Diseases: Infectious Diseases Society of America, American Society for Microbiology, and Pan American Society for Clinical Virology Recommendations on the Regulation of Laboratory-developed Tests.

Science.gov (United States)

Caliendo, Angela M; Couturier, Marc R; Ginocchio, Christine C; Hanson, Kimberly E; Miller, Melissa B; Walker, Kimberly E; Frank, Gregory M

2016-07-15

In 2014, the US Food and Drug Administration (FDA) proposed to regulate laboratory-developed tests (LDTs)-diagnostics designed, manufactured, and used within a single laboratory. The Infectious Diseases Society of America, the American Society for Microbiology, and the Pan American Society for Clinical Virology recognize that the FDA is committed to protecting patients. However, our societies are concerned that the proposed regulations will limit access to testing and negatively impact infectious diseases (ID) LDTs. In this joint commentary, our societies discuss why LDTs are critical for ID patient care, hospital infection control, and public health responses. We also highlight how the FDA's proposed regulation of LDTs could impair patient access to life-saving tests and stifle innovation in ID diagnostics. Finally, our societies make specific recommendations for the FDA's consideration to reduce the burden of the proposed new rules on clinical laboratories and protect patients' access to state-of-the art, quality LDTs. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

Philosophical Reflection Smart-Society as a New Model of the Information Society and its Impact on the Education of the 21st Century

Directory of Open Access Journals (Sweden)

Valentina Voronkova

2017-07-01

Full Text Available This article presents philosophical and educational reflection of smart-society as a new model of the information society and presents its impact on human (intellectual capital. It reveals timeliness of this topic, which is innovative and hardly developed. It analyses international experience in establishment and growth of smart-society and dimensions of axiological field of smart-society, which is based on axiological matrix of information and knowledge, which are considered and being civilized dimensions of modern society. The main idea is to prove the evolution of the information society to smart-society and the possibility of establishment of smart-society in Ukraine. The analysis of smart-society formation was made and its characteristics were defined, which claims priority role in the world information space formation and contribute to the competitiveness of Ukraine in the international information space.

Mast cell degranulation breaks peripheral tolerance.

Science.gov (United States)

de Vries, V C; Wasiuk, A; Bennett, K A; Benson, M J; Elgueta, R; Waldschmidt, T J; Noelle, R J

2009-10-01

Mast cells (MC) have been shown to mediate regulatory T-cell (T(reg))-dependent, peripheral allograft tolerance in both skin and cardiac transplants. Furthermore, T(reg) have been implicated in mitigating IgE-mediated MC degranulation, establishing a dynamic, reciprocal relationship between MC and T(reg) in controlling inflammation. In an allograft tolerance model, it is now shown that intragraft or systemic MC degranulation results in the transient loss of T(reg) suppressor activities with the acute, T-cell dependent rejection of established, tolerant allografts. Upon degranulation, MC mediators can be found in the skin, T(reg) rapidly leave the graft, MC accumulate in the regional lymph node and the T(reg) are impaired in the expression of suppressor molecules. Such a dramatic reversal of T(reg) function and tissue distribution by MC degranulation underscores how allergy may causes the transient breakdown of peripheral tolerance and episodes of acute T-cell inflammation.

T cell suppression by naturally occurring HLA-G-expressing regulatory CD4+ T cells is IL-10-dependent and reversible.

Science.gov (United States)

Huang, Yu-Hwa; Zozulya, Alla L; Weidenfeller, Christian; Schwab, Nicholas; Wiendl, Heinz

2009-08-01

CD4(+) T cells constitutively expressing the immune-tolerogenic HLA-G have been described recently as a new type of nT(reg) (HLA-G(pos) T(reg)) in humans. HLA-G(pos) T(reg) accumulate at sites of inflammation and are potent suppressors of T cell proliferation in vitro, suggesting their role in immune regulation. We here characterize the mechanism of how CD4(+) HLA-G(pos) T(reg) influence autologous HLA-G(neg) T(resp) function. Using a suppression system free of APC, we demonstrate a T-T cell interaction, resulting in suppression of HLA-G(neg) T(resp), which is facilitated by TCR engagement on HLA-G(pos) T(reg). Suppression is independent of cell-cell contact and is reversible, as the removal of HLA-G(pos) T(reg) from the established coculture restored the proliferative capability of responder cells. Further, HLA-G(pos) T(reg)-mediated suppression critically depends on the secretion of IL-10 but not TGF-beta.

Participation in a post-socialist society

DEFF Research Database (Denmark)

Eskemose Andersen, Jørgen

2004-01-01

Urban development and urban planning in a society like the Mozambican under transformation from a centrally planned society to a market oriented democracy. The transition from a one party state to a multiparty state involving participation of the population is a lengthy process with many obstacles...

Body image in non-western societies

NARCIS (Netherlands)

Edmonds, A.; Cash, T.

2012-01-01

This article discusses a range of body modification and conceptions of the body in non-Western societies. It also analyzes difficulties in applying the primarily Western psychological notion of body image to different societies. Body modification is a near human universal, but has many meanings and

November 2017 Arizona thoracic society notes

Directory of Open Access Journals (Sweden)

Robbins RA

2017-11-01

Full Text Available No abstract available. Article truncated after 150 words. The November 2017 Arizona Thoracic Society meeting was held on Wednesday, November 15, 2017 at the HonorHealth Rehabilitation Hospital beginning at 6:30 PM. This was a dinner meeting with a lecture followed by case presentations. There were 15 in attendance representing the pulmonary, critical care, sleep, allergy, infectious disease and radiology communities. At the beginning of the meeting several issues were discussed: 1. CME offered by the Southwest Journal of Pulmonary and Critical Care Medicine (SWJPCC is currently offered to only the Southwest state thoracic societies and the Mayo Clinic. After discussion it was felt that this restriction of access was no longer appropriate and CME credits should be available to all. 2. Efforts continue to obtain CME for the Arizona Thoracic Society meetings. Our Chapter Representative, Dr. Gerry Schwartzberg, is approaching this with the American Thoracic Society. Locally, HonorHealth sent out a survey on CME needs. Members were encouraged …

April 2014 Arizona thoracic society notes

Directory of Open Access Journals (Sweden)

Robbins RA

2014-04-01

Full Text Available No abstract available. Article truncated at 150 words. The April 2014 Arizona Thoracic Society meeting was held on Wednesday, 4/23/2014 at Scottsdale Shea Hospital beginning at 6:30 PM. There were 15 in attendance representing the pulmonary, critical care, sleep, pathology and radiology communities. It was announced that there will be a wine tasting with the California, New Mexico and Colorado Thoracic Societies at the American Thoracic Society International Meeting. The tasting will be led by Peter Wagner and is scheduled for the Cobalt Room in the Hilton San Diego Bayfront on Tuesday, May 20, from 4-8 PM. Guideline development was again discussed. The consensus was to await publication of the IDSA Cocci Guidelines and respond appropriately. George Parides, Arizona Chapter Representative, gave a presentation on Hill Day. Representatives of the Arizona, New Mexico and Washington Thoracic Societies met with their Congressional delegations, including Rep. David Schweikert, to discuss the Cigar Bill, NIH funding, and the Medicare Sustainable Growth ...

CERN hosts Physics and Society Forum

CERN Multimedia

Katarina Anthony

2012-01-01

On 28-29 March, CERN hosted the fifth edition of the European Physical Society's “Physics and Society” forum. The forum addresses the role of physicists in general society – be they in education, politics, industry or communication. This year, attendees looked at how physicists have adapted - and can continue to adapt - to work in the economic marketplace.   “The forums began back in 2006, as a special closing event for the 2005 World Year of Physics,” explains Martial Ducloy, former President of the French Physical Society and Chair of the EPS Forum Physics and Society. “We decided to keep the sessions going, as they gave physicists a venue to discuss the non-scientific issues that influence their daily work. As the world's largest international physics laboratory – and the venue for this year's EPS Council – CERN seemed the ideal place to host this year's forum.” The forum ...

The judiciary in a free society

Directory of Open Access Journals (Sweden)

Miguel Morgado

2006-04-01

Full Text Available There is increasing debate about the “crisis of the judiciary”, although in modern societies this expression (independent from its concrete content specifically designates the crises of liberal democratic justice, or, it could be said, the crises of the judiciary in liberal and democratic society. Thus, any discussion about the “crisis of the judiciary” appears to demand a contextual framing that helps to clarify the place occupied by the judicial branch in societies such as ours. This article seeks to elucidate this context, from the political and constitutional point of view. The perspective of the History of Political Thinking is considered the most useful, to the degree to which it points to the origin of the intellectual foundation not only of modern judicial power, but of modern society as a whole. In this article, John Locke and Montesquieu are presented as two essential authors because they have made an indelible contribution to this dual structure.

Strong adhesion by regulatory T cells induces dendritic cell cytoskeletal polarization and contact-dependent lethargy.

Science.gov (United States)

Chen, Jiahuan; Ganguly, Anutosh; Mucsi, Ashley D; Meng, Junchen; Yan, Jiacong; Detampel, Pascal; Munro, Fay; Zhang, Zongde; Wu, Mei; Hari, Aswin; Stenner, Melanie D; Zheng, Wencheng; Kubes, Paul; Xia, Tie; Amrein, Matthias W; Qi, Hai; Shi, Yan

2017-02-01

Dendritic cells are targeted by regulatory T (T reg) cells, in a manner that operates as an indirect mode of T cell suppression. In this study, using a combination of single-cell force spectroscopy and structured illumination microscopy, we analyze individual T reg cell-DC interaction events and show that T reg cells exhibit strong intrinsic adhesiveness to DCs. This increased DC adhesion reduces the ability of contacted DCs to engage other antigen-specific cells. We show that this unusually strong LFA-1-dependent adhesiveness of T reg cells is caused in part by their low calpain activities, which normally release integrin-cytoskeleton linkage, and thereby reduce adhesion. Super resolution imaging reveals that such T reg cell adhesion causes sequestration of Fascin-1, an actin-bundling protein essential for immunological synapse formation, and skews Fascin-1-dependent actin polarization in DCs toward the T reg cell adhesion zone. Although it is reversible upon T reg cell disengagement, this sequestration of essential cytoskeletal components causes a lethargic state of DCs, leading to reduced T cell priming. Our results reveal a dynamic cytoskeletal component underlying T reg cell-mediated DC suppression in a contact-dependent manner. © 2017 Chen et al.

The History of the Soil Science Society of Nigeria

Science.gov (United States)

Okechukwu Chude, Victor

2013-04-01

The Soil Science Society of Nigeria (SSSN) founded in 1968, is a registered member of the African Soil Science Association, International Union of Soil Science and the Global Soil Partnership. The Society aims at promoting and fostering better understanding of basic and applied Soil Science in Nigeria. The society also strives to enhance the dissemination of knowledge in all aspects of Soil science and shares ideas with National and International Societies through conferences, symposium, lectures, seminars and journal publications. The numerical strength of the society is 600 members (student, ordinary ,life and corporate). The soil science society of Nigeria has provided invaluable services in the formulation of agricultural land and fertilizer use strategies and policies of the country. The existing reconnaissance soil map of Nigeria typifies one of the major professional services rendered to the country by the society and its members. Despite the numerous contributions the society has made to the advancement of soil science in the country, the larger society is not aware of the its existence. This is largely because of our limited soil extension activities to land users due to lack of funds. If the society can attract donor funds, this will go a long way in enhancing the capacity and capability of the society.

[From the French Society of Plastic and Reconstructive Surgery to the French Society of Plastic Reconstructive and Aesthetic Surgery].

Science.gov (United States)

Glicenstein, J

2004-04-01

(The) 3rd December 1952, 11 surgeons and other specialists found the French Society of Plastic and Reconstructive Surgery (SFCPR) which was officially published on (the) 28 September 1953. The first congress was during October 1953 and the first president as Maurice Aubry. The first secretary was Daniel Morel Fatio. The symposiums were after about three of four times each year and the thematic subjects were initially according the reconstructive surgery. The review "Annales de chirurgie plastique" was free in 1956. The members of the Society were about 30 initially, but their plastic surgery in the big hospitals at Paris and other big towns in France. The "specialty" of plastic surgery was created in 1971. On "syndicate", one French board of plastic reconstructive and aesthetic surgery, the increasing of departments of plastic surgery were the front of increasing of the plastic surgery in French and of the number of the French Society of Plastic Reconstructive surgery (580 in 2003). The French Society organized the International Congress of Plastic Surgery in 1975. The society SFCPR became the French Society of plastic reconstruction and Aesthetic Surgery (SFCPRE) in 1983 and the "logo" (front view) was in the 1994 SOF.CPRE.

Some Questions for the Information Society.

Science.gov (United States)

Marien, Michael

1983-01-01

Though frequently forecasted and referred to, the so-called information society is likely but not necessarily inevitable. Questions are raised about such a society, including its impact on work, commerce, health, education, entertainment, politics, intergroup relations, families, and the impact of anticipated changes on the quality of life.…

Information Assurance and the Information Society

NARCIS (Netherlands)

Luiijf, H.A.M.

1998-01-01

Society is on the verge of a new era: the information age. Economical changes, a new way of looking at services and new types of conflict are forecasted. Some glimpses of these changes were noticed during the Persian Gulf War. Government decision units, organisations, society and critical industries

Information Assurance and the Information Society

NARCIS (Netherlands)

Luiijf, H.A.M.

1999-01-01

Society is on the verge of a new era: the information age. Economical changes, a new way of looking at services and new types of conflict are forecasted. Some glimpses of these changes were noticed during the Persian Gulf War. Government decision units, organisations, society and critical industries

MAR binding protein SMAR1 favors IL-10 mediated regulatory T cell function in acute colitis

Energy Technology Data Exchange (ETDEWEB)

Mirlekar, Bhalchandra; Patil, Sachin [Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India); Bopanna, Ramanamurthy [Experimental Animal Facility, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India); Chattopadhyay, Samit, E-mail: samit@nccs.res.in [Chromatin and Disease Biology Laboratory, National Centre for Cell Science, Ganeshkhind, Pune 411007 (India)

2015-08-21

T{sub reg} cells are not only crucial for controlling immune responses to autoantigens but also prevent those directed towards commensal pathogens. Control of effector immune responses by T{sub reg} cells depend on their capacity to accumulate at inflammatory site and accordingly accommodate to inflammatory environment. Till date, the factors associated with maintaining these aspects of T{sub reg} phenotype is not understood properly. Here we have shown that a known nuclear matrix binding protein SMAR1 is selectively expressed more in colonic T{sub reg} cells and is required for their ability to accumulate at inflammatory site and to sustain high levels of Foxp3 and IL-10 expression during acute colitis. Elimination of anti-inflammatory subsets revealed a protective role for IL-10 producing T{sub reg} cells in SMAR1{sup −/−} mice. Moreover, a combined action of Foxp3 and SMAR1 restricts effector cytokine production and enhance the production of IL-10 by colonic T{sub reg} cells that controls acute colitis. This data highlights a critical role of SMAR1 in maintaining T{sub reg} physiology during inflammatory disorders. - Highlights: • SMAR1 is essential to sustain high level of Foxp3 and IL-10 in T{sub reg} cells. • SMAR1{sup −/−} T{sub reg} cells produce pro-inflammatory cytokine IL-17 leads to inflammation. • IL-10 administration can control the inflammation in SMAR1{sup −/−} mice. • Both Foxp3 and SMAR1 maintain T{sub reg} phenotype that controls colitis.

40 CFR 52.170 - Identification of plan.

Science.gov (United States)

2010-07-01

...) Chapter 14—CAIR NO X Ozone Season Trading Program General Provisions Reg. 19.1401 Adoption of Regulations 07/15/07 09/26/07 (72 FR 54556) Reg. 19.1402 State Trading Budget 07/15/07 09/26/07 (72 FR 54556) Reg... Offsets 07/03/06 04/12/07 (72 FR 18394) Reg. 31.305 Zones Targeted for Economic Development 07/03/06 04/12...

Development process of subjects society

Directory of Open Access Journals (Sweden)

A. V. Reshetnichenko

2014-08-01

Full Text Available Background due to defining the role of people in the development of society and the almost complete absence of scientific management processes capable of progressive development of both individuals and social communities, and nations, and civilization in general. In order to overcome inherent subjectivist methodology of knowledge, psyholohizatorskyh, hiperpolityzovanyh and utilitarian approach, the authors proposed a three-tier system of business processes of society. The conceptual core of the approach consists in the detection task as logical - mathematical laws of subjects of primary, secondary and higher levels of development, and on the mechanisms of their formation and practice. The solution of the tasks allowed the authors to reveal the structure of both the ascending and descending processes of economic society. Thus, the analysis of individual carriers upward changes as «individual», «individuality», «person» and «personality» showed conditionality determination of their activities with «anthropometric», «ethnic», «demographic» and «ideological» mechanisms. Nature as common carriers downstream changes revealed using correlative related «groups», «group «, «groups» and «communities» whose activity is due to «vitalistic», «education», «professional» and «stratification» mechanisms. To disclose the nature and organization of secondary and higher levels of economic society by the authors introduced the category of «citizen», «heneralista», «human space», «human galactic» ‘formation and development is causing «status», «Persona logical», «humanocentric», «institutional», «cluster», «kontaminatsiyni» and other mechanisms. One of the main achievements of the work, the authors consider the possibility of further development and practical implementation of new quality management processes of economic society based multimodal dialectical logic.

Society and Social Power

Directory of Open Access Journals (Sweden)

Janani Harish

2014-10-01

Full Text Available Society is the source of immense power. Over the past few centuries humanity has record­ed phenomenal growth in its collective capacity for accomplishment, as reflected in the 12-fold growth in global per capita income since 1800. The remarkable achievements in living standards, longevity, science, technology, industry, education, democracy, human rights, peace and global governance are the result of the exponential development of the capacity of society to harness human energies and convert them into social power for productive purposes. Today, humanity possesses the power and capabilities needed to fully meet the multi-dimensional challenges confronting global society. The source of this energy is people. Human energy is transformed into social power by the increasing reach, frequency and complexity of human relationships. Society is a complex living network of organized relationships between people. Its power issues from channelizing our collective energies in productive ways by means of organizing principles such as coordination, systems, specialization of function, hierarchy of authority, and integration. This immense social power remains largely underutilized. Social science needs to evolve a comprehensive, trans-disciplinary understanding of the roots of social power and the process by which it is generated, distributed and applied. This knowledge is the essential foundation for formulating effective social policies capable of eradicating forever persistent poverty, unemployment and social inequality. This article is based on a series of lectures delivered by the author in the WAAS-WUC course on “Toward a Trans-disciplinary Science of Society” at Dubrovnik on September 1-3, 2014. It traces the development of social power in different fields to show that human and social capital are inexhaustible in potential. The more we harness them, the more they grow. Unleashing, directing, channeling and converting human potential into social

Representation of monsoon intraseasonal oscillations in regional climate model: sensitivity to convective physics

KAUST Repository

Umakanth, U.

2015-11-07

The aim of the study is to evaluate the performance of regional climate model (RegCM) version 4.4 over south Asian CORDEX domain to simulate seasonal mean and monsoon intraseasonal oscillations (MISOs) during Indian summer monsoon. Three combinations of Grell (G) and Emanuel (E) cumulus schemes namely, RegCM-EG, RegCM-EE and RegCM-GE have been used. The model is initialized at 1st January, 2000 for a 13-year continuous simulation at a spatial resolution of 50 km. The models reasonably simulate the seasonal mean low level wind pattern though they differ in simulating mean precipitation pattern. All models produce dry bias in precipitation over Indian land region except in RegCM-EG where relatively low value of dry bias is observed. On seasonal scale, the performance of RegCM-EG is more close to observation though it fails at intraseasonal time scales. In wave number-frequency spectrum, the observed peak in zonal wind (850 hPa) at 40–50 day scale is captured by all models with a slight change in amplitude, however, the 40–50 day peak in precipitation is completely absent in RegCM-EG. The space–time characteristics of MISOs are well captured by RegCM-EE over RegCM-GE, however it fails to show the eastward propagation of the convection across the Maritime Continent. Except RegCM-EE all other models completely underestimates the moisture advection from Equatorial Indian Ocean onto Indian land region during life-cycle of MISOs. The characteristics of MISOs are studied for strong (SM) and weak (WM) monsoon years and the differences in model performances are analyzed. The wavelet spectrum of rainfall over central India denotes that, the SM years are dominated by high frequency oscillations (period <20 days) whereas little higher periods (>30 days) along with dominated low periods (<20 days) observed during WM years. During SM, RegCM-EE is dominated with high frequency oscillations (period <20 days) whereas in WM, RegCM-EE is dominated with periods >20�

Quality-of-life in technological society

NARCIS (Netherlands)

R. Veenhoven (Ruut)

2012-01-01

textabstractABSTRACT Effects of technology on the quality of human life can be assessed by comparing quality of life in more and in less modern societies. The quality of life in a society can be measured by how long and happy its inhabitants live. Using these indicators I start with a

Network-Based Community Brings forth Sustainable Society

Science.gov (United States)

Kikuchi, Toshiko

It has already been shown that an artificial society based on the three relations of social configuration (market, communal, and obligatory relations) functioning in balance with each other formed a sustainable society which the social reproduction is possible. In this artificial society model, communal relations exist in a network-based community with alternating members rather than a conventional community with cooperative mutual assistance practiced in some agricultural communities. In this paper, using the comparison between network-based communities with alternating members and conventional communities with fixed members, the significance of a network-based community is considered. In concrete terms, the difference in appearance rate for sustainable society, economic activity and asset inequality between network-based communities and conventional communities is analyzed. The appearance rate for a sustainable society of network-based community is higher than that of conventional community. Moreover, most of network-based communities had a larger total number of trade volume than conventional communities. But, the value of Gini coefficient in conventional community is smaller than that of network-based community. These results show that communal relations based on a network-based community is significant for the social reproduction and economic efficiency. However, in such an artificial society, the inequality is sacrificed.

Space and commodity-based society

Directory of Open Access Journals (Sweden)

Gvozden Vladimir

2015-01-01

Full Text Available The space is privileged in the commodity-based society. It is well known that the economic space in the 19th and 20th centuries rapidly managed to subordinate all other areas 'conveying and instilling in them their own meanings and goals' (G. Milatović. A new form of space that qualifies commodity society was created, marked by dualities: openness-closeness, private-public, sameness-difference. This paper is an attempt to criticize the usual analysis of the categories of commodity-space, linked to the ambivalent role of the state as a guarantor of the functioning of the commodity-based society, as well as its controlling instance. The increasing delocalisation of the political changes the nature of the space in the commodity-based society. Privileged areas are produced that create an illusion of protection of consumers (shopping malls, gated communities, theme parks, video surveillance, while at the same time social differentiation and identification are produced through the symbolic order of commodities and a sense of inclusion or exclusion from that order. At the same time, the examples of tourism and selling places demonstrate that such a commodity-space unusually easy reconciles sameness and difference. It entails uniformity to help achieve the fluctuation of goods, while insisting on the local as different, especially in terms of the role of particularity in the global trade.

Leukemia & Lymphoma Society

Science.gov (United States)

... be the exclusive property of The Leukemia & Lymphoma Society which in its sole discretion may use this material as it sees fit. I agree to the terms of the Standard Photography Release.* Submit * This field is required * Please fix the validation error messages in the Form Your story was ...

On the Present State of Information Society Studies.

Science.gov (United States)

Duff, Alistair S.

2001-01-01

Assesses the present condition of the emerging specialism of information society studies. Topics include the information economy; information technology; the information explosion; the Japanese version of information society; information society as social democracy; sociology and information science; scholarly journals; and the need for…

Development of Social Building Societies in Poland

OpenAIRE

Anna Białek-Jaworska

2004-01-01

The article describes a genesis of Social Building Societies in Poland starting from National Housing Fund through Workers Housing Estates Society in 1934.1939, announcement of cheap building system in New Housing Order in 1993 to Barbara Blida's and Irena Herbst's legislative initiative leading to establish Social Building Societies in 1995. According to International Permanent Social Building Committee social housing consists in supply houses with fixed minimum standard of comfort and equip...

Sexuality and Sexual Rights in Muslim Societies

OpenAIRE

Liz Ercevik Amado

2009-01-01

In August 2008, the Coalition for Sexual and Bodily Rights in Muslim Societies (CSBR) organized the CSBR Sexuality Institute, the first international Institute on sexuality and sexual rights in Muslim societies in Malaysia. Liz Amado presents how the Institute expanded the discourse, knowledge and thinking around sexuality in Muslim societies, as well as providing a unique space for the much needed exchange of information and experience among sexual rights advocates. Development (2009) 52, 59...

DEVELOPING STUDENTS’ SKILLS FOR THE KNOWLEDGE SOCIETY

OpenAIRE

Andreea ZAMFIR

2010-01-01

This study explores the manner in which students’ skills for the knowledge society could be developed. Our conclusion justifies the effort invested in designing new methods of developing students’ skills needed within the knowledge society. It has been concluded that information and communication technology creates a vast opportunity to improve the skills and competences needed within the knowledge society. The study was conducted using the knowledge base built up through research of literatu...

Information Society Visions in the Nordic Countries

DEFF Research Database (Denmark)

Henten, Anders; Kristensen, Thomas Myrup

2000-01-01

This paper analyses the information society visions put forward by the governments/administrations of the Nordic countries and compares them to the visions advanced at the EU-level. The paper suggests that the information society visions constitute a kind of common ideology for almost the whole...... political spectrum although it is characterised by a high degree of neo-liberal thinking. It is further argued that there is no distinctly Nordic model for an information society....

KNOWLEDGE SOCIETY, GENERAL FRAMEWORK FOR KNOWLEDGE BASED ECONOMY

Directory of Open Access Journals (Sweden)

Dragos CRISTEA

2011-03-01

Full Text Available This paper tries to present the existent relation between knowledge society and knowledge based economy. We will identify the main pillars of knowledge society and present their importance for the development of knowledge societies. Further, we will present two perspectives over knowledge societies, respectively science and learning perspectives, that directly affects knowledge based economies. At the end, we will conclude by identifying some important questions that must be answered regarding this new social paradigm.

Babad Banyumas Wirjaatmadjan: Magical-Religious Values in Banyumas Society

Directory of Open Access Journals (Sweden)

Ali Ma'ruf

2018-04-01

Full Text Available This research explains the describing of magical-religious values in Banyumas society that contain in Babad Banyumas Wirjaatmajan. Banyumas society as one part of Javanese has trust to something that magical. A Belief system or religion in Javanese has a connection that related to the ancestors. Trust to Magical power in the Banyumas society that grows until now. Words or ancestral discourse are claimed important by Java and Banyumas society that still uphold the traditional values.  Traditional values in Java and Banyumas society always identified with something magical. This research tries to give the knowledge about custom, habit, and the mindset of Banyumas and Javanese society to the magical-religious values that grow in the society through Babad Banyumas Wirjaatmadjan. Magical-Religious values in the research are taken from an ancestral discourse of Banyumas are Raden Baribin, Adipati Wargautama I, and Joko Kaiman that written in Babad Banyumas Wirjaatmadjan. Magical-Religious in Banyumas society, they are pepali of Sabtu Pahing, pepali of eat white cucumber, pepali persecute partridge that all of that is the command of Banyumas society ancestors.

Geoethics and the Role of Professional Geoscience Societies

Science.gov (United States)

Kieffer, S. W.; Palka, J. M.; Geissman, J. W.; Mogk, D. W.

2014-12-01

Codes of Ethics (Conduct) for geoscientists are formulated primarily by professional societies and the codes must be viewed in the context of the Goals (Missions, Values) of the societies. Our survey of the codes of approximately twenty-five societies reveals that most codes enumerate principles centered on practical issues regarding professional conduct of individuals such as plagiarism, fabrication, and falsification, and the obligation of individuals to the profession and society at large. With the exception of statements regarding the ethics of peer review, there is relatively little regarding the ethical obligations of the societies themselves. In essence, the codes call for traditionally honorable behavior of individual members. It is striking, given that the geosciences are largely relevant to the future of Earth, most current codes of societies fail to address our immediate obligations to the environment and Earth itself. We challenge professional organizations to consider the ethical obligations to Earth in both their statements of goals and in their codes of ethics. Actions by societies could enhance the efforts of individual geoscientists to serve society, especially in matters related to hazards, resources and planetary stewardship. Actions we suggest to be considered include: (1) Issue timely position statements on topics in which there is expertise and consensus (some professional societies such as AGU, GSA, AAAS, and the AMS, do this regularly, yet others not at all.); (2) Build databases of case studies regarding geoethics that can be used in university classes; (3) Hold interdisciplinary panel discussions with ethicists, scientists, and policy makers at annual meetings; (4) Foster publication in society journals of contributions relating to ethical questions; and (5) Aggressively pursue the incorporation of geoethical issues in undergraduate and graduate curricula and in continuing professional development.

Society of Thoracic Surgeons

Science.gov (United States)

... Apply for Membership Membership Directory Pay Your Dues Industry Mailing List License & eBlast Communications Programs Advertise on ... Hotel Discount Copyright © 2017 The Society of Thoracic Surgeons. ...

Towards E-Society Policy Interoperability

Science.gov (United States)

Iannella, Renato

The move towards the Policy-Oriented Web is destined to provide support for policy expression and management in the core web layers. One of the most promising areas that can drive this new technology adoption is e-Society communities. With so much user-generated content being shared by these social networks, there is the real danger that the implicit sharing rules that communities have developed over time will be lost in translation in the new digital communities. This will lead to a corresponding loss in confidence in e-Society sites. The Policy-Oriented Web attempts to turn the implicit into the explicit with a common framework for policy language interoperability and awareness. This paper reports on the policy driving factors from the Social Networks experiences using real-world use cases and scenarios. In particular, the key functions of policy-awareness - for privacy, rights, and identity - will be the driving force that enables the e-Society to appreciate new interoperable policy regimes.

DOES CIVIL SOCIETY CREATE SOCIAL ENTREPRENEURS?

Directory of Open Access Journals (Sweden)

Gauca Oana

2013-07-01

Full Text Available The purpose of this paper is to analyze whether civil society itself can enhance or stimulate the creation of social entrepreneurs, by studying the traits of the civil society and the various definitions attributed to it. The main question that the paper wants to answer to is Does civil society create social entrepreneurs and the main approach used in this research paper is the theoretical one. By studying existing articles and books on the topic, the paper tries to emphasize the various dimensions that civil society can embrace, as pictured by various authors, as well as how these dimensions can relate to social entrepreneurs and the emergence of social businesses. The paper is not meant to be a breakthrough in the field, but rather to launch a question that is related to very important topics these days, social entrepreneurship, social innovation, social businesses and their connection to a very much debated topic-civil society. The paper is work-in progress and wants to stimulate research regarding the search of the sources of social entrepreneurship, in order to analyze them and better establish them as incubators for the future. It wants to be of use to whoever is researching the concepts illustrated above, as well as for those who want to get in touch with the new buzz words of the academic and entrepreneurial fields. The hereby paper stands, as previously stated, in a theoretical framework and the findings represent a mere analysis of the cause-effect relationship between the characteristics of civil society and those of social entrepreneurs. However, we are of the opinion that it can be a very good starting point for the ones interested in the domain, to analyze more sources of social entrepreneurship or further refine the answer to the question addressed in this article.

Remaking Public Spaces for Civil Society

Science.gov (United States)

Ranson, Stewart

2012-01-01

The collective action predicaments of the time require citizens to participate in remaking the governance of civil society so that they can become engaged and cooperate together. Can citizens become makers of civil society? This article draws upon Hannah Arendt's "On Revolution" to provide a theory of remaking in which citizens come together to…

The Duplex Society.

Science.gov (United States)

Schorr, Alvin L.

1984-01-01

The duplex society, in which the poor live in close proximity to others but in a separate compartment, is already with us. Unless something deeply changes about family income, more than one-third of future generations will come to adulthood having spent a portion of their childhood in official poverty. (RM)

Consumers, Nanotechnology and Responsibilities Operationalizing the Risk Society.

OpenAIRE

Throne-Holst, H.

2012-01-01

Risks are high on the agenda in our society, to the extent that we might refer to the society as a risk society. Our society experiences emerging technologies, like nanotechnology. Different actors respond to this in a variety of ways. Among these are the consumers, an important, but neglected category of actors in this context. Arguably it is in our role as consumers we first encountered nanotechnology, in the form of nano-enabled products at the consumers market. What consumers think and do...

Big Society? Disabled people with the label of learning disabilities and the queer(y)ing of civil society

OpenAIRE

Goodley, Dan; Runswick-Cole, Katherine

2014-01-01

This paper explores the shifting landscape of civil society alongside the emergence of ‘Big Society’ in the UK. We do so as we begin a research project Big Society? Disabled people with learning disabilities and Civil Society [Economic and Social Research Council (ES/K004883/1)]; we consider what ‘Big Society’ might mean for the lives of disabled people labelled with learning disabilities (LDs). In the paper, we explore the ways in which the disabled body/mind might be thought of as a locus o...

Helping CERN give back to society

CERN Multimedia

2014-01-01

The CERN & Society mission: ‘To spread the CERN spirit of scientific curiosity for the inspiration and benefit of society.’   Digital library schools in Africa, Arts@CERN, a beam line for schools competition and perhaps soon a dedicated biomedical research facility: CERN infrastructure and expertise have a great influence on society, and we have the potential to do much more. For that, however, we need help, and that’s why we have launched the CERN & Society initiative, which this week sees the publication of a new website for those who want to understand more about how our research touches everyday life, as well as for those who wish to help CERN in this new endeavour. Fundamental research fulfils a very human need. The quest to understand the universe we live in is as old as humanity itself, and CERN is in the vanguard of that effort today. For our scientists and engineers, pushing technology to the limit is part of their day job, and in doing so they ...

Korean society of mechanical engineers 60 years

International Nuclear Information System (INIS)

2005-12-01

This book introduces 60 years of Korean society of mechanical engineers with birth, foundation, development process, change of enforcement regulation and articles of association, important data of this association, 60 years of parts, committee and branch, business of association like academic event, publication, technical development business, supporting research centers, bond Korean society of mechanical engineers and mechanical industry and development of related organizations, development for industrial fields and development direction of Korean society of mechanical engineers.

Roles of libraries in information society | Awojobi | Information ...

African Journals Online (AJOL)

Through the revi ew of relevant literature, the paper examined the roles of libraries in information society. The information society is characterised by proliferation of information through the use of Information and Communication Technology (ICT). One major principle of an information society is accessibility to information ...

46 CFR 188.10-59 - Recognized classification society.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Recognized classification society. 188.10-59 Section 188... VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 188.10-59 Recognized classification society. This term means the American Bureau of Shipping or other classification society...

Society in Manfaluti Innovative Literature (Arabic

Directory of Open Access Journals (Sweden)

Farman Ullah Khan

2016-07-01

Full Text Available This article describes the social problems face by the Egyptian people in the late nineteenth and beginning of twentieth century which are tackled by the writer Mustafā Lutfī Manfalūtī in his articles and parables. In the mentioned period the Egyptian society was prone to immoralities carved by the English regime. Bad governance, deprivation of the Egyptian society from their basic rights, and negligence towards Islam were the major shortcomings on the part of the ruling elite. While poverty, problems of women, immorality, offence and other social evils were the main troubles on the part of Egyptian society. This article deals with the way the writer tackled those problems in his writings

Japanese women in the contemporary society

Directory of Open Access Journals (Sweden)

Dinca Violeta Mihaela

2017-07-01

Full Text Available The purpose of this paper is to examine Japanese society and present contemporary issues with emphasis on the changes in the role, status and preferences of Japanese women within the Japanese society, through the years. The first part of the paper makes an overview on the evolution of the role of women in Japanese society during Shogunate until now, focusing mainly on increasing Japanese women's status within the enterprise. In the second part of the paper, the author exposes the results of several studies on the effects on the marketing of luxury for Japanese women, highlighting the correlation between increased interest to be as competitive in the workplace and enhancing concern for luxury brands.

Major Risk Factors for Heart Disease: Diabetes

Science.gov (United States)

... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Tests That Can Help Protect Your Heart Health

Science.gov (United States)

... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Medications

Science.gov (United States)

... Red Dress &reg , and Red Dress &reg are registered trademarks of U.S. Department of Health and Human Services. National Wear Red Day &reg is a registered trademark of the U.S. Department of Health and Human ...

Some health aspects of high-energy society

International Nuclear Information System (INIS)

Cook, E.

1975-01-01

The intensive use of inanimate energy in industrialized or high-energy society has subsidized research, development, and higher education and has brought about changes in nutrition and life-style that have led to great advances in public health and medicine. The emergence of high-energy society, however, has brought with it a new set of health problems, within which the direct effects of measurable pollution may turn out to be more easily dealt with than some of the indirect and hard-to-calculate consequences of high energy use. High-energy society is critically dependent on energy-intensive transport systems, and these systems in turn are dependent upon a continual supply of petroleum products. In the short-term, the aorta of any industrialized nation is its petroleum-supply network. In the longer run, high-energy society faces the depletion and exhaustion of all the nonrenewable resources on which it has fed. Even if technology provides adequate substitute energy systems, high-energy society may deteriorate socially from inability to cope with affluence

Pittsburgh Science Technology Society Project: Instruction Modules. Interrelationships Science--Technology--Society.

Science.gov (United States)

O'Brien, George, Ed.

This collection of instruction modules studies the interactions of science, technology, and society (STS) using five activity sets. The introduction module includes activities which show students the STS relationships in their world, develop good organizational skills, develop an understanding of who and what a scientist is, develop graphing…

Challenges and opportunities for informational societies from the present to become reliable learning and knowledge societies

Directory of Open Access Journals (Sweden)

Eduardo ROMERO SÁNCHEZ

2013-12-01

Full Text Available This article pretend to describe the principal social trends and cultural features that prevail today, too look the philosophical foundation of thinking, feel , living and to give an educative  response and accepted to the axiological reality  and cultural present. In modern western societies great paradoxes and contradictions coexist: economical growth, technological development and greater dimensions of freedom, but also great consumption, cultural deterioration, technological dependence and unique thought. Given this we talk about the great possibilities and at the same time of the terrible threats that exist in that modern information societies. In order to become acquainted with this reality, we have focused the analysis in 3 key aspects: the impact of digital devolution, the condition of culture in contemporary society, and the need of a “new education”.

The Black Man in American Society.

Science.gov (United States)

Framingham Public Schools, MA.

GRADE OR AGES: Junior high school. SUBJECT MATTER: The black man in American society. ORGANIZATION AND PHYSICAL APPEARANCE: There are four major parts each with an overview. The four parts concern a) the African heritage of the black man, b) the American exploitation of the black man, c) the black man's contribution to American society, d) the…

State or Society? We Need Both

Science.gov (United States)

Taylor, Jane; Appleton, Victoria

2011-01-01

The concept of Big Society provides inspiration--working "bottom up" to promote "collective action, reciprocity and a new, more engaged relationship between local people and public services". With so much written about the theory of the Big Society, this seems like an ideal time to put a little more practical detail into the mix. The authors argue…

46 CFR 42.05-60 - Recognized classification society.

Science.gov (United States)

2010-10-01

... 46 Shipping 2 2010-10-01 2010-10-01 false Recognized classification society. 42.05-60 Section 42... FOREIGN VOYAGES BY SEA Definition of Terms Used in This Subchapter § 42.05-60 Recognized classification society. The term recognized classification society means the American Bureau of Shipping or other...

46 CFR 90.10-35 - Recognized classification society.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Recognized classification society. 90.10-35 Section 90... VESSELS GENERAL PROVISIONS Definition of Terms Used in This Subchapter § 90.10-35 Recognized classification society. The term recognized classification society means the American Bureau of Shipping or other...

Phenotypic complexity of T regulatory subsets in patients with B-chronic lymphocytic leukemia.

Science.gov (United States)

Biancotto, Angélique; Dagur, Pradeep K; Fuchs, John C; Wiestner, Adrian; Bagwell, C Bruce; McCoy, J Philip

2012-02-01

Increased numbers of T regulatory (T(reg)) cells are found in B-chronic lymphocytic leukemia, but the nature and function of these T(regs) remains unclear. Detailed characterization of the T(regs) in chronic lymphocytic leukemia has not been performed and the degree of heterogeneity of among these cells has not been studied to date. Using 15-color flow cytometry we show that T(reg) cells, defined using CD4, CD25, and forkhead box P3 (FOXP3), can be divided into multiple complex subsets based on markers used for naïve, memory, and effector delineation as well as markers of T(reg) activation. Furthermore FOXP3(+) cells can be identified among CD4(+)CD25(-) as well as CD8(+)CD4(-) populations in increased proportions in patients with chronic lymphocytic leukemia compared with healthy donors. Significantly different frequencies of naïve and effector T(regs) populations are found in healthy donor controls compared with donors with chronic lymphocytic leukemia. A population of CCR7(+)CD39(+) T(regs) was significantly associated with chronic lymphocytic leukemia. This population demonstrated slightly reduced suppressive activity compared with total T(regs) or T(regs) of healthy donors. These data suggest that FOXP3-expressing cells, particularly in patients with chronic lymphocytic leukemia are much more complex for T(reg) sub-populations and transitions than previously reported. These findings demonstrate the complexity of regulation of T-cell responses in chronic lymphocytic leukemia and illustrate the use of high-dimensional analysis of cellular phenotypes in facilitating understanding of the intricacies of cellular immune responses and their dysregulation in cancer.

Nuclear energy and society

International Nuclear Information System (INIS)

Sobajima, Makoto; Shimooka, Hiroshi; Tanaka, Yasumasa; Fujii, Yasuhiko; Misima, Tsuyoshi

2004-01-01

Nuclear energy has a strong relation to a society. However, due to accidents and scandals having occurred in recent years, people's reliability to nuclear energy has significantly swayed and is becoming existence of a worry. Analyzing such a situation and grasping the problem contained are serious problems for people engaging in nuclear field. In order that nuclear energy is properly used in society, communication with general public and in nuclear power plant site area are increasingly getting important as well as grasping the situation and surveying measures for overcoming the problems. On the basis of such an analysis, various activities for betterment of public acceptance of nuclear energy by nuclear industry workers, researchers and the government are proposed. (J.P.N.)

Branding Cities, Changing Societies

DEFF Research Database (Denmark)

Ooi, Can-Seng

Societal changes are seldom discussed in the literature on city branding. The time element is important because it highlights the fluctuating reality of society. The city brand message freezes the place but in fact, the city branding exercise is a continuous process. Society emerges too. City...... brands are supposed to accentuate the uniqueness of the city, be built from the bottom-up and reflect the city's identity. This paper highlights three paradoxes, pointing out that city branding processes can also make cities more alike, bring about societal changes and forge new city identities. A city...... branding campaign does not just present the city, it may change the city. The relationships between the branding exercise and the city are intertwined in the evolution of the place....

How Global is Global Civil Society?

Directory of Open Access Journals (Sweden)

Neera Chandhoke

2015-08-01

Full Text Available In recent times the concept of global civil society has made its appearance on national and international intellectual, as well as political agendas, in a major way. It is of some interest that two other concepts, both of which call for transcendence of national boundaries in precisely the same way as global civil society does, have also made their appearance on the scene of intellectual debates at roughly the same time: the concept of cosmopolitanism and that of transnational justice. All three concepts have dramatically expanded the notion of commitment to one’s fellow beings beyond the nation state. And all three concepts have extended critiques of policies that violate the dignity of human beings from national governments to the practices of inter-national institutions such as the World Bank, the International Monetary Fund, and the World Trade Forum. In sum the inter-related concepts of global civil society, cosmopolitanism, and transnational justice have greatly enlarged the traditional domain of political theory. And yet for any political theorist who is acutely conscious of the phenomenon of power, these concepts are not unproblematic. For the practices of global civil society may just reinforce the intellectual and the moral power of the West over the postcolonial world. This is particularly true of say global human rights organizations. This paper will attempt to raise some questions of the concept and the practices of global civil society from the perspective of the countries of the South.

A history of the Teratology Society.

Science.gov (United States)

Shepard, T H; Barr, M; Brent, R L; Hendrickx, A; Kochhar, D; Oakley, G; Scott, W J

2000-11-01

The 39-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, along with listings of the Warkany Lectures, the postgraduate courses, and officers of the Society. A year-by-year description of the events, including the scientific and social content of the annual meetings and changes in the business of the Society, is given, in many cases using comments from the past presidents. The valuable and unique diversity of the members is discussed and illustrated, presenting the disciplines and main research area of the presidents. The number of submitted abstracts and the various categories are tabulated, averaging the number and type over four periods. Within the past 10 years, a significant increase in the number of abstracts dealing with epidemiology and developmental biology is evident. The Society's development is compared with that of a human, and the question is asked: Have we reached the maturational stage of old age or senescence, or is the Society still maturing gracefully? This question needs further discussion by all the members. During the past 40 years, we have developed the scientific basis to prevent birth defects caused by rubella, alcoholism, and folate deficiency, as well as many other prenatal exposures. We must now engage in the political battles to obtain the resources needed to conduct further research and to implement the prevention programs, as well as to provide care and rehabilitation for persons with birth defects. Copyright 2000 Wiley-Liss, Inc.

Digital Literacy: Tools and Methodologies for Information Society

Science.gov (United States)

Rivoltella, Pier Cesare, Ed.

2008-01-01

Currently in a state of cultural transition, global society is moving from a literary society to digital one, adopting widespread use of advanced technologies such as the Internet and mobile devices. Digital media has an extraordinary impact on society's formative processes, forcing a pragmatic shift in their management and organization. This…

Knowledge production and transmission in a changing society ...

African Journals Online (AJOL)

Knowledge production and transmission in a changing society: challenges facing law lecturers in a distance education environment in South Africa. S Scott. Abstract. In this article I highlight the challenges facing a law lecturer in a multicultural society in transformation where the student is being prepared to serve society in ...

American Cancer Society: the world's wealthiest "nonprofit" institution.

Science.gov (United States)

Epstein, S S

1999-01-01

The American Cancer Society is fixated on damage control--diagnosis and treatment--and basic molecular biology, with indifference or even hostility to cancer prevention. This myopic mindset is compounded by interlocking conflicts of interest with the cancer drug, mammography, and other industries. The "nonprofit" status of the Society is in sharp conflict with its high overhead and expenses, excessive reserves of assets and contributions to political parties. All attempts to reform the Society over the past two decades have failed; a national economic boycott of the Society is long overdue.

Valie EXPORT Society. Overlok

Index Scriptorium Estoniae

2001-01-01

Valie EXPORT Society asutasid 23. okt. 1999. a. Frankfurdis Kadi Estland, Killu Sukmit ja Mari Laanemets, kui olid külastanud austria naiskunstniku Valie Exporti näitust. Rühmituse aktsioonide kirjeldus

Risk and society

International Nuclear Information System (INIS)

Tubiana, M.; Vrousos, C.; Pages, J.P.; Carde, C.

1999-01-01

This book brings together the communications presented at the colloquium 'risk and society' held in Paris (France) on November 1998. During this colloquium, the various aspects of risk and of its management were discussed by medical specialists, historians, industrialists, engineers, philosophers, lawyers, politicians and administration representatives. The first theme concerns the controversies generated by the development of some activities (genetics, bio-technologies, nuclear and radiations use). The second theme concerns the management of risks and the way to conciliate the point of view of authorities and citizens (confidence of the public with respect to experts, scientists, industrialists, government and administrative representatives, role played by the media). The debates that took place during the colloquium have shown that the public opinion concerning the nuclear activities or the new technologies greatly depends on the ideological attitudes and on the public's likes and dislikes with respect to some categories of actors (distrust with respect to public decisions, fears with respect to changes and future, nostalgia of the past). The following aspects are reviewed: Notions of risk and hazard (risk and health, risk in today's society, medicine and society, the point of view of the industrialists and of the scientific and technical specialists); from the psychological aspects of the risk to its social aspects (survey of the risk assessment battlefield, social attenuation and amplification of risk, the feeling of risks in Europe, insecurity and delinquency, controversies around radioactivity and health); the negotiation and communication about risks (risk and public health, negotiation around risks, risks and information dissemination about the public debate, communication and crisis, evolution of risk communication, comparison between American and European approaches, the Seveso directive); the public debate and the evolution of risks management (the

Testing the Teacher's Report Form Syndromes in 20 Societies

Science.gov (United States)

Ivanova, Masha Y.; Achenbach, Thomas M.; Rescorla, Leslie A.; Dumenci, Levent; Almqvist, Fredrik; Bathiche, Marie; Bilenberg, Niels; Bird, Hector; Domuta, Anca; Erol, Nese; Fombonne, Eric; Fonseca, Antonio; Frigerio, Alessandra; Kanbayashi, Yasuko; Lambert, Michael C.; Leung, Patrick; Liu, Xianchen; Minaei, Asghar; Roussos, Alexandra; Simsek, Zeynep; Weintraub, Sheila; Wolanczyk, Tomasz; Zubrick, Stephen; Zukauskiene, Rita; Verhulst, Frank C.

2007-01-01

Standardized assessment instruments developed in one society are often used in other societies. However, it is important to determine empirically how assessment instruments developed in one society function in others. The present study tested the fit of the Teacher's Report Form syndrome structures in 20 diverse societies using data for 30,030 6-…

Global civil society: between nation states and transnational corporations

Directory of Open Access Journals (Sweden)

S. A. Kvitka

2017-06-01

Full Text Available Global civil society is the subject of the formation of a new world order and the modern humanitarian outlook, which is based on the primacy of justice and human rights. One of the actors head of global civil society is an international non-governmental organizations. But wrong to equate global civil society with the activities of these organizations only. Mostly they influence governments and their humanitarian and international politics. Meanwhile, the role of global civil and its society various institutions is much greater and significant. The article discusses the various aspects of the civil society from the position that it took place between transnational companies (TNCs and nation-states. The role of the latter is gradually reduced - economic regulation take on multinationals and public administration is a field of activity of various institutions and structures that scientists considered it as a manifestation of global civil society. In Ukraine, which is also involved in the process of globalization, global civil society is one of the main factors of its national civil society.

Radiation Sensitivity of Societies

International Nuclear Information System (INIS)

Uray, I.; Hille, R.; Rohloff, F.

1998-01-01

Investigating the mean dose values as well as dose distributions of the inhabitants in a large number of settlements maybe set down, that the generally calculated mean exposure is a good measure to estimate the collective dose for a settlement or for a large region. Its uncertainty is however too high, and the dose distribution is very broad (250-300%) to estimate the external exposure of any single person. However, models may take into account more details of influencing factors. First of all the surveying of the local contamination density distribution could be more detailed and more accurate. Measure and distribution of the internal exposure (is not the subject of the present work, but it is similarly problematic. In this situation it is very difficult to search the dose-effect relationships exactly, and is also difficult to satisfy the people that their fears are unjustified. Society pays the costs of the nuclear industry and of the possible consequences as well. But society can neither control the nuclear industry nor the possible consequences at all. Both science and single people are waiting for more and detailed information. If we can not decrease the r adiation sensitivity of societies , then the consequences of Chernobyl will be growing unnecessarily, and it can strongly retard the justified development of the nuclear industry as well. (author)

Inter-Society Research Committee

International Nuclear Information System (INIS)

Akiyama, Mamoru; Higuchi, Masahisa.

1996-01-01

World-wide tendencies and circumstances for nuclear power cannot be said to be moving full of sail with a favorable wind, due to nuclear power plant accidents and comparatively little economical benefit. The present Nuclear Power Plant situation is that some personnel understand a need for the development from the viewpoint of efficient energy usage in the world and environmental problems like global warming. At the same time others oppose future nuclear development from the viewpoint of safety problems and economic cost. These issues may end nuclear development worldwide. Nuclear development must be considered from an international viewpoint and other various aspects. Therefore, all countries concerned should cooperative in the adjustment of research carried out by each country. Nuclear power's future must be efficient in the utilization of limited resources (money, manpower and facilities). It is concluded that the ISRC should only discuss technical matters on nuclear engineering, independent from political influence. Societies agreeing to this idea, provide the ISRC with money and/or manpower and/or facilities. The ISRC will consist of a research program committee and research task forces. Members of the Research Program Committee are the chairmen of the research task forces who are also society representatives. The Committee will discuss research programs and resources. The research task forces will consist of one society representative chairman and specialists on the program

impact of cooperative societies in national development

African Journals Online (AJOL)

PROF EKWUEME

affected all the facets and segments of the. Nigerian society and .... They take decisions and make policies ... purchase, supply, marketing and hulling of such goods and ..... formation and promotion of cooperative societies. It undertook to ...

Adaptables in the post-industrial society

DEFF Research Database (Denmark)

Stylsvig Madsen, Ulrik

2006-01-01

How can contemporary industrialized production meet the requirements of a growing complexity and dynamism in a global society? In a society affected by globalization and the never-ending flow of information, the need for artefacts to reinforce the identity of organizations and individuals...... is growing. The mission of architecture is then to form a framework of identity for the particular function or individual, a framework capable of distinguishing the function / the individual from one another and from the surrounding society. Industrial production within the construction business is therefore...... met with increasing demands for individual solutions. The question then is how this challenge is met in the best way by industrialized production, technologically (products/solutions) as well as theoretically (conceptual approach)...

A Brief History of Manchester Astronomical Society

Science.gov (United States)

Kilburn, K. J.

Manchester Astronomical Society celebrated its centenary in September 2003. But that centenary was of a hundred years as the MAS: the history of the society goes back much further, and can be traced directly to that great era of.public awareness of astronomy and amateur interest in Victorian England in the last half of the nineteenth century. Allan Chapman has discussed this period in detail, so the present paper concentrates on the MAS's particular influence on Manchester astronomers and recent work on the history of the society.

A Learned Society's Perspective on Publishing.

Science.gov (United States)

Suzuki, Kunihiko; Edelson, Alan; Iversen, Leslie L; Hausmann, Laura; Schulz, Jörg B; Turner, Anthony J

2016-10-01

Scientific journals that are owned by a learned society, like the Journal of Neurochemistry (JNC), which is owned by the International Society for Neurochemistry (ISN), benefit the scientific community in that a large proportion of the income is returned to support the scientific mission of the Society. The income generated by the JNC enables the ISN to organize conferences as a platform for members and non-members alike to share their research, supporting researchers particularly in developing countries by travel grants and other funds, and promoting education in student schools. These direct benefits and initiatives for ISN members and non-members distinguish a society journal from pure commerce. However, the world of scholarly publishing is changing rapidly. Open access models have challenged the business model of traditional journal subscription and hence provided free access to publicly funded scientific research. In these models, the manuscript authors pay a publication cost after peer review and acceptance of the manuscript. Over the last decade, numerous new open access journals have been launched and traditional subscription journals have started to offer open access (hybrid journals). However, open access journals follow the general scheme that, of all participating parties, the publisher receives the highest financial benefit. The income is generated by researchers whose positions and research are mostly financed by taxpayers' or funders' money, and by reviewers and editors, who frequently are not reimbursed. Last but not least, the authors pay for the publication of their work after a rigorous and sometimes painful review process. JNC itself has an open access option, at a significantly reduced cost for Society members as an additional benefit. This article provides first-hand insights from two former Editors-in-Chief, Kunihiko Suzuki and Leslie Iversen, about the history of JNC's ownership and about the difficulties and battles fought along the way to

Heart failure outcomes with empagliflozin in patients with type 2 diabetes at high cardiovascular risk: results of the EMPA-REG OUTCOME® trial

Science.gov (United States)

Fitchett, David; Zinman, Bernard; Wanner, Christoph; Lachin, John M.; Hantel, Stefan; Salsali, Afshin; Johansen, Odd Erik; Woerle, Hans J.; Broedl, Uli C.; Inzucchi, Silvio E.

2016-01-01

Abstract Aims We previously reported that in the EMPA-REG OUTCOME® trial, empagliflozin added to standard of care reduced the risk of 3-point major adverse cardiovascular events, cardiovascular and all-cause death, and hospitalization for heart failure in patients with type 2 diabetes and high cardiovascular risk. We have now further investigated heart failure outcomes in all patients and in subgroups, including patients with or without baseline heart failure. Methods and results Patients were randomized to receive empagliflozin 10 mg, empagliflozin 25 mg, or placebo. Seven thousand and twenty patients were treated; 706 (10.1%) had heart failure at baseline. Heart failure hospitalization or cardiovascular death occurred in a significantly lower percentage of patients treated with empagliflozin [265/4687 patients (5.7%)] than with placebo [198/2333 patients (8.5%)] [hazard ratio, HR: 0.66 (95% confidence interval: 0.55–0.79); P heart failure hospitalization or cardiovascular death of 35 over 3 years. Consistent effects of empagliflozin were observed across subgroups defined by baseline characteristics, including patients with vs. without heart failure, and across categories of medications to treat diabetes and/or heart failure. Empagliflozin improved other heart failure outcomes, including hospitalization for or death from heart failure [2.8 vs. 4.5%; HR: 0.61 (0.47–0.79); P heart failure at baseline in both treatment groups, but were no more common with empagliflozin than with placebo. Conclusion In patients with type 2 diabetes and high cardiovascular risk, empagliflozin reduced heart failure hospitalization and cardiovascular death, with a consistent benefit in patients with and without baseline heart failure. PMID:26819227

Is Society Capable of Learning? Beyond a Metaphysical Foundation

Science.gov (United States)

Su, Ya-hui

2016-01-01

There is an assumption that any contemporary society should become a learning society to maintain stability in the face of change. Although proponents and policymakers take for granted that a society has the ability to learn, can this idea be defended? There is a problem in determining exactly what is meant by a learning society that learns. One…

Society 3.0: How Technology Is Reshaping Education, Work and Society

Science.gov (United States)

Wilen-Daugenti, Tracey

2012-01-01

Higher education in the U.S. has traditionally prepared students for work and social success, but with families, work, and society itself undergoing revolutionary change, is this preparation sufficient to develop the 21st-century workforce? This book explores how evolving family structures, new ways of balancing work and personal lives, and rapid…

CERN announces major conference on the information society

CERN Multimedia

2003-01-01

"A side event to the World Summit on the Information Society (Geneva, December 2003) will explore the past and future contributions of science to the information society. Hosted by CERN , the Role of Science in the Information Society (RSIS) conference will bring together scientists and representatives of funding agencies and governments worldwide" (1 page).

ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease : A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.

Science.gov (United States)

Doherty, John U; Kort, Smadar; Mehran, Roxana; Schoenhagen, Paul; Soman, Prem

2017-12-01

This document is 1 of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. This document addresses the evaluation and use of multimodality imaging in the diagnosis and management of valvular heart disease, whereas the second, companion document addresses this topic with regard to structural heart disease. Although there is clinical overlap, the documents addressing valvular and structural heart disease are published separately, albeit with a common structure. The goal of the companion AUC documents is to provide a comprehensive resource for multimodality imaging in the context of valvular and structural heart disease, encompassing multiple imaging modalities.Using standardized methodology, the clinical scenarios (indications) were developed by a diverse writing group to represent patient presentations encountered in everyday practice and included common applications and anticipated uses. Where appropriate, the scenarios were developed on the basis of the most current American College of Cardiology/American Heart Association guidelines.A separate, independent rating panel scored the 92 clinical scenarios in this document on a scale of 1 to 9. Scores of 7 to 9 indicate that a modality is considered appropriate for the clinical scenario presented. Midrange scores of 4 to 6 indicate that a modality may be appropriate for the clinical scenario, and scores of 1 to 3 indicate that a modality is considered rarely appropriate for the clinical scenario.The primary objective of the AUC is to provide a framework for the assessment of these scenarios by practices that will

An updated history of the Teratology Society.

Science.gov (United States)

Shepard, Thomas H; Barr, Mason; Brent, Robert L; Hendrickx, Andrew; Kochhar, Devendra; Oakley, Godfrey; Scott, William J; Rogers, John M

2010-05-01

The 49-year history of the Teratology Society is reviewed. An abbreviated history is outlined in table form, with listings of the Warkany Lectures, the Continuing Education Courses, and officers of the society. The original article was updated to include the years 2000 to 2010. A year-by-year description of the events is given, including the scientific and social content of the annual meetings and changes in the business of the society, in many cases using comments from the past presidents. The valuable and unique diversity of the members is discussed and illustrated, presenting the disciplines and main research areas of the presidents. The number of submitted abstracts and the various categories are tabulated, averaging the number and type over successive periods. A significant increase in the number of abstracts dealing with epidemiology and developmental biology is evident. The society's development is compared to that of a human, and the question was asked by Shephard et al. (2000): Have we reached the maturational stage of old age or senescence, or is the society still maturing gracefully? This question needs further discussion by all the members. By 2010, many positive changes are happening to revitalize the society. During the past 50 years, we have developed the scientific basis to prevent birth defects caused by rubella, alcoholism, and folate deficiency, as well as other prenatal exposures. We are now taking advantage of advances in many fields to begin shaping the Teratology Society of the 21st century. We must now engage in political battles to obtain the resources needed to conduct further research and to implement prevention programs, as well as to provide care and rehabilitation for persons with birth defects. 2010 Wiley-Liss, Inc.

Crime-social risk in contemporary society

Directory of Open Access Journals (Sweden)

Vilić Dragana

2017-01-01

Full Text Available Crime, as a form of violation of law (A. Giddens, is one of the social risks. One of the negative consequences of the development of a modern, global society is the globalization of criminality (M. Kostić & F. Mirić. Criminality can only be discussed with the development and elaboration of the legal system in the modern sense of the word (including criminal law, but in societies there have always been certain types of norms and beliefs that have influenced human behavior and against which (in correctness (M. Ivanović. Unlike a positive right that cannot fully follow the dynamics of change in society that influence the definition of a crime, sociology should constantly seek new elements that extend this notion (new, unpredictable, unlimited. The paper analyzes the causes of criminality, its distribution, types (violent, property, etc., relation to other notions (deviance, delinquency and crime and its consequences in contemporary society, in order to look at the risk of crime, to seek an adequate social response to This negative phenomenon, and provides an analysis of the penal policy and the role of a prison institution for the offender's conversion (M. Foucault.

CERN to host conference on information society

CERN Multimedia

CERN will host a conference on the Role of Science in the Information Society (RSIS) in December. This conference will focus on ensuring that the information society benefits people to the greatest extent possible, especially in developing regions.

Society for Ambulatory Anesthesia

Science.gov (United States)

... SAMBA Link Digital Newsletter Educational Bibliography Research IARS/Anesthesia & Analgesia SCOR About SCOR Sponsor SAMBA Meetings Affinity Sponsor Program We Represent Ambulatory and Office-Based Anesthesia The Society for Ambulatory Anesthesia provides educational opportunities, ...

Society of Interventional Radiology

Science.gov (United States)

... Picture yourself in L.A. Register now SIR Essentials Purchase/register Search SIR's entire catalog for educational ... Quality Improvement Clinical practice MACRA Matters Health Policy, Economics, Coding Toolkits Society of Interventional Radiology 3975 Fair ...

Valie EXPORT Society Rooseumis

Index Scriptorium Estoniae

2002-01-01

Malmös Rooseumi Kaasaegse Kunsti Keskuses näitus "Baltic Babel". Projekt koosneb Läänemeremaade linnades tegutsevate innovatiivsete gruppide aktsioonidest. Kuraator Charles Esche. Esinejatest (Eestist Valie Export Society: Kadi Estland, Killu Sukmit)

Teaching the Intersection of Climate and Society

Science.gov (United States)

Thomson, C.; Ting, M.; Orlove, B. S.

2014-12-01

As the first program of its kind, the M.A. in Climate and Society at Columbia University educates students on how climate affects society and vice versa. The 12-month interdisciplinary Master's program is designed to allow students from a wide variety of backgrounds to gain knowledge in climate science and a deep understanding of social sciences and how they related to climate. There are currently more than 250 alumni applying their skills in fields including energy, economics, disaster mitigation, journalism and climate research in more than a dozen countries worldwide. The presentation will highlight three key components of the program that have contributed to its growth and helped alumni become brokers that can effectively put climate science in the hands of the public and policymakers for the benefit of society. Those components include working with other academic departments at Columbia to successfully integrate social science classes into the curriculum; the development of the course Applications in Climate and Society to help students make an overt link between climate and its impacts on society; and providing students with hands-on activities with practitioners in climate-related fields.

Coevolution of nutrigenomics and society: ethical considerations.

Science.gov (United States)

Korthals, Michiel

2011-12-01

To optimize the coevolution of nutrigenomics and society (ie, the reciprocal stimulation of both developments), I analyzed chances for a fruitful match between normative concepts and strategies of both developments. Nutrigenomics embodies ≥ 3 normative concepts. First, food is exclusively interpreted in terms of disease prevention. Second, striving for health is interpreted as the quantification of risks and prevention of diseases through positive food-gene interactions. The third normative idea is that disease prevention by the minimization of risks is an individual's task. My thesis was that these concepts of nutrigenomics would not easily match with concepts of food and health of various food styles in Western societies, which, for instance, parents in the case of metabolic programming endorse and with a philosophical view of the relation between food, health, and the meaning of life. Next, I reflected on the nonsynchronized coevolution of nutrigenomics and society because of this mismatch and introduced the concept of the fair representation of food styles in nutrigenomic developments. To synchronize and optimize the coevolution of nutrigenomics and society, I propose that the research policy of nutrigenomics should change to a research partnership with society on the basis of fair representation.

Architecture for the silvering society

DEFF Research Database (Denmark)

Andersson, Jonas E; Rönn, Magnus

Abstract In the context of the universal ageing process that is currently taking place in western society, the organization of architecture competitions that deals with space for dependent ageing comes of relevance. Based on the welfare regime theory, it could be argued that this type of architec......Abstract In the context of the universal ageing process that is currently taking place in western society, the organization of architecture competitions that deals with space for dependent ageing comes of relevance. Based on the welfare regime theory, it could be argued that this type...... by the Swedish Institute of Assistive Technology (SIAT), which administered the governmental allocation of 50 million SEK. The research material was accumulated by use of internet searches, interviews and questionnaires. The analysis applied pattern seeking and involved close reading, document analysis...... on ageing, eldercare and space. Consequently, architecture competitions that focus on the emerging ageing society could be seen as a restrained type of space for architects to digress. National welfare goals and existing means to achieve these goals act as inhibitors for an innovative spatial preparation...

ICT for society through society: Application of code-sprints as entrepreneurial enabler

CSIR Research Space (South Africa)

Coetzee, L

2010-08-31

Full Text Available Information and Communications Technology for Development (ICT4D) is faced with the challenge of creating sustainable and innovative success stories which speak to the creation of an inclusive digital society. Initial attempts at ICT4D had limited...

1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis.

Science.gov (United States)

Wei, Chunyan; Mei, Jie; Tang, Lingli; Liu, Yukai; Li, Dajin; Li, Mingqing; Zhu, Xiaoyong

2016-12-01

Foxp3 + regulatory T (T reg ) cells contribute to the local dysfunctional immune environment in endometriosis, an estrogen-dependent gynecological disease, which affects the function of ectopic endometrial tissue clearance by the immune system. The reason for the high percentage of peritoneal T reg in endometriosis patients is unknown. Here, we show that the proportion of peritoneal T reg cells increases as endometriosis progresses. To determine the probable mechanism, we established a naive T cell-macrophage-endometrial stromal cell (ESC) co-culture system to mimic the peritoneal cavity microenvironment. After adding 1-methyl-tryptophan (1-MT), a specific inhibitor of indoleamine 2,3-dioxygenase-1 (IDO1), to the co-culture system, we found that the differentiation of T reg cells, mainly IL-10 + T reg cells, decreased. Therefore, 1-MT-pretreated ESCs-educated T reg cells performed impaired suppressive function. Moreover, estrogen promoted the differentiation of T reg cells by elevating IDO1 expression in the ectopic lesion. Subsequently, we examined mannose receptor C, type 2 (MRC2), which is an up-stream molecule of IL-10, by bioinformatics analysis and real-time PCR validation. MRC2 expression in ectopic ESCs was notably lower than that in normal ESCs, which further negatively regulated the expression of IDO1 and Ki-67 in ESCs. Furthermore, MRC2 is required for T reg differentiation in the ectopic lesion, especially that for CD4 high T reg . Therefore, MRC2-silenced ESCs-educated T reg manifested a stronger suppressive function in vitro. Consistently, the percentage of T reg increased when MRC2-shRNA was administered in the peritoneal cavity of endometriosis-disease mice model. Besides, 1-MT improved the condition of endometriosis, in terms of reducing the number and weight of total ectopic lesions in vivo. These results indicate that the estrogen-IDO1-MRC2 axis participates in the differentiation and function of T reg and is involved in the development of

Civil society and the ‘commanding heights’:

DEFF Research Database (Denmark)

Spear, Roger; Paton, Rob

Civil society associations, including voluntary and community groups, trade unions, faithbased organisations, co-operatives and mutuals, have long influenced the economy. Civil society associations can run businesses and they can run organisations that aim to influence businesses. Together, these...

The Kurdish Resurrection Society (1942-1945

Directory of Open Access Journals (Sweden)

Sohrab Yazdani

2017-12-01

Full Text Available The Kurdish Resurrection Society (known as Komeley Jiyanewey Kurd was the first political society that was founded after August and September 1941 and following the Anglo-Soviet Invasion of Iran. This society arose from traditional and modern strata of urban Kurdish petty bourgeois in Mahabad. The present study aims at discussing the following questions applying a descriptive-analytical approach and using the historical resources and studies: 1. What is the role of the new social and historical structure of the Iranian Kurdistan in forming the Kurdish Resurrection Society? 2. How did the nationalism discourses of the modern absolutist Pahlavi state result in evolving the ideology of Kurdish Resurrection Society (KRS? The evolution of KRS among the traditional and modern strata was the result of the changes and developments occurred in the structure of social forces in Iranian Kurdistan. These changes took place in the aftermath of modernization-related plans of the modern absolutist Pahlavi state in renewing the social structure and cultural assimilation of this era. This policy provoked a new form of collectivism based upon linguistic and ethnic minorities. In other words, while weakening and isolating the forces of the previous order, modernization paved the social and political ways needed for the emergence of new urban Kurdish forces. The Kurdish leaders and elites, affected by the nationalistic discourse of the modern absolutist Pahlavi state, attempted to provide a new definition of their ethnic identity. Thus, the nationalism discourse of the modern absolutist state led to the emergence of a particularistic nationalism discourse of KRS among the Kurds.

Language Contact in Nigerian Multilingual Society

Directory of Open Access Journals (Sweden)

C.A. Adetuyi

2017-12-01

Full Text Available Multilingual society, being a society that has more than one significant lan-guage group is a sociolinguistic phenomenon that arises as a result of language contact but the fundamental problem in this type of society is that to enthrone one of the languages can be accepted conveniently as the National language. Any attempt to enthrone one of the languages at the expense of the other has proven a failure due to the fact that it appears as distinct, which is inherent and regrettably discriminating and domineering on the other languages and this dies in the mine of ethnic bickering. In Nigeria, like many other African nations, multilingualism is a rule, rather than an exemption, the problem of 'forging ahead' is of crucial importance. Among the competing languages that scramble for national recognition or official status, whether indigenous or for-eign, one must emerge as the official language (the language of administration and education at some levels, the language of relevance, from the competition for the purpose of uniting the nation. Fortunately, English has emerged as that privileged language of its kind. The Nigerian society is irretrievably heterogeneous. Students from diverse ethno-linguistic, cultural and economic groups are exposed quite early to several languages, including their mother tongues and English. Nigerian scholars have variously, as have others examined the connection between multilingualism and interference; we avail ourselves of such studies in situating our reflections. This paper thus looks into the importance of language, most especially English language in the multilingual society.

The beginnings of the Southern Child/Pediatric Neurology Society.

Science.gov (United States)

Dyken, Paul Richard; Bodensteiner, John B

2015-04-01

The founding and early development of the Southern Pediatric Neurology Society was in many ways parallel to that of the Child Neurology Society. The organization started out as the Southern Child Neurology Society but the name was changed at the time of incorporation so as to avoid confusion of identity and purpose with the larger Child Neurology Society. Although there are archives of early days and the later development of the Southern Pediatric Neurology Society, the details have never been set down in a narrative explaining the events that led to the development of the organization. In this paper, we try to produce a written record of the history of the founding and early development of the Southern Pediatric Neurology Society. © The Author(s) 2014.

Pediatric Endocrinology Nurses Society

Science.gov (United States)

... Join Now International Welcome to PENS The Pediatric Endocrinology Nursing Society (PENS) is committed to the development ... nurses in the art and science of pediatric endocrinology nursing. Learn More Text1 2018 PENS Call for ...

Neurosurgery certification in member societies of the World Federation of Neurosurgical Societies: Asia.

Science.gov (United States)

Gasco, Jaime; Braun, Jonathan D; McCutcheon, Ian E; Black, Peter M

2011-01-01

To objectively compare the complexity and diversity of the certification process in neurological surgery in member societies of the World Federation of Neurosurgical Societies. This study centers in continental Asia. We provide here an analysis based on the responses provided to a 13-item survey. The data received were analyzed, and three Regional Complexity Scores (RCS) were designed. To compare national board experience, eligibility requirements for access to the certification process, and the obligatory nature of the examinations, an RCS-Organizational score was created (20 points maximum). To analyze the complexity of the examination, an RCS-Components score was designed (20 points maximum). The sum of both is presented in a Global RCS score. Only those countries that responded to the survey and presented nationwide homogeneity in the conduction of neurosurgery examinations could be included within the scoring system. In addition, a descriptive summary of the certification process per responding society is also provided. On the basis of the data provided by our RCS system, the highest global RCS was achieved by South Korea and Malaysia (21/40 points) followed by the joint examination of Singapore and Hong-Kong (FRCS-Ed) (20/40 points), Japan (17/40 points), the Philippines (15/40 points), and Taiwan (13 points). The experience from these leading countries should be of value to all countries within Asia. Copyright © 2011 Elsevier Inc. All rights reserved.

Science and society: the impact of computing at CERN on society

CERN Multimedia

CERN. Geneva

2014-01-01

Lecture in English, with simultaneous interpreting into French CERN is often referred to as the place “where the web was born”. The world-wide-web has fundamentally changed society and launched a wave of new global industries. The world-wide-web happened because there was a specific problem that was seen as an Information Technology (IT) challenge by its inventors. As the scientific programme of CERN has progressed, new IT challenges have been faced such as how to handle the mind-boggling amount of data that is produced by the Large Hadron Collider (LHC). Being able to face those challenges has contributed to the success of the LHC and the discovery of the Higgs particle. This public lecture will explore some of those challenges, how they have been tackled and what impact they are having beyond physics and ultimately on society as a whole. ------ Conférence en anglais – traduction simultanée en français On parle souvent du CERN comme le « berceau du web ». Le web a changé notre société en p...

FOXP3+ regulatory T cells in normal prostate tissue, postatrophic hyperplasia, prostatic intraepithelial neoplasia, and tumor histological lesions in men with and without prostate cancer.

Science.gov (United States)

Davidsson, Sabina; Andren, Ove; Ohlson, Anna-Lena; Carlsson, Jessica; Andersson, Swen-Olof; Giunchi, Francesca; Rider, Jennifer R; Fiorentino, Michelangelo

2018-01-01

The tumor promoting or counteracting effects of the immune response to cancer development are thought to be mediated to some extent by the infiltration of regulatory T cells (T regs ). In the present study we evaluated the prevalence of T reg populations in stromal and epithelial compartments of normal, post atrophic hyperplasia (PAH), prostatic intraepithelial neoplasia (PIN), and tumor lesions in men with and without prostate cancer. Study subjects were 102 men consecutively diagnosed with localized prostate cancer undergoing radical prostatectomy and 38 men diagnosed with bladder cancer undergoing cystoprostatectomy without prostate cancer at the pathological examination. Whole mount sections from all patients were evaluated for the epithelial and stromal expression of CD4 + T regs and CD8 + T regs in normal, PAH, PIN, and tumor lesions. A Friedmańs test was used to investigate differences in the mean number of T regs across histological lesions. Logistic regression was used to estimate crude and adjusted odds ratios (OR) for prostate cancer for each histological area. In men with prostate cancer, similarly high numbers of stromal CD4 + T regs were identified in PAH and tumor, but CD4 + T regs were less common in PIN. Greater numbers of epithelial CD4+ T regs in normal prostatic tissue were positively associated with both Gleason score and pT-stage. We observed a fourfold increased risk of prostate cancer in men with epithelial CD4 + T regs in the normal prostatic tissue counterpart. Our results may suggest a possible pathway through which PAH develops directly into prostate cancer in the presence of CD4 + T regs and indicate that transformation of the anti-tumor immune response may be initiated even before the primary tumor is established. © 2017 The Authors. The Prostate Published by Wiley Periodicals Inc.

The focus of women in The American Fertility Society.

Science.gov (United States)

Haseltine, F P; Wentz, A C

1984-09-01

This article reports survey responses from 71 female members of the American Fertility Society during the Society's 1984 annual meeting. Survey questions concern 1) demographic factors such as rank, degree, title, address, and number of children, 2) field of specialization and research interests, and 3) what the Society can do for its meeting participants. The typical respondent is a physician living in the Eastern United States and employed as an assistant professor in an academic setting. In vitro fertilization is the greatest area of interest, followed by general practice, endocrine and male infertility, contraception, and fertility surgery. Survey responses show that women are interested in 1) networking, 2) increased visibility at professional meetings, 3) information about research possibilities and grants, 4) child care provision at Society meetings, and 5) more basic science and physiology oriented presentions in the program. In response to networking interests, the Society will make available information from the surveyed members. Since 16% of respondents have a PH.D., and 77% are employed in academics, the Society should consider more basic presentations. The need for day care indicates changes in Society membership. The Society plans to conduct similar surveys on a regular basis.

The role of risk in society

International Nuclear Information System (INIS)

Whipple, G.H.

The effects on human health caused by production of energy are best understood in terms of mortality. The term risk is used to mean the years of productive life lost as the result of premature death. As a society becomes more energy intensive, the risks to that society from energy production should increase in direct proportion, yet, the advent of the industrial revolution, and subsequent increase in production and use of energy, has resulted in doubled life expectancy at birth. The relation between risk reduction and cost appears to resemble a rectangular hyperbola. Institutionalized efforts at risk reduction may be reaching a point of diminishing returns, whereas individual efforts offer large gains in life expectancy for little effort and expense. A society that strives to reduce all risks will go bankrupt. (J.T.A.)

Locating Science in Society across Europe

DEFF Research Database (Denmark)

Mejlgaard, Niels; Bloch, Carter Walter; Degn, Lise

2012-01-01

-level and individual-level data, we further show a connection between national differences and the public’s satisfaction with their own role as participants in science and technology. In countries where science communication culture is weak, where science plays a minor role in policy-making, and where institutions......In search of differences and similarities in relation to the role and location of science in European societies, we use empirical information from 37 countries as a platform for developing typologies concerning dimensions of science in society. These capture clusters of countries and reveal...... significant heterogeneity across Europe, providing a point of departure for international learning, while also demonstrating the challenges that the European institutions face in their promotion of a European Research Area, shared priorities and a common model of science in society. Combining national...

Women in European Culture and Society

DEFF Research Database (Denmark)

Simonton, Deborah Leigh

A new and major contribution to the field, Women in European Culture and Society is a transnational history of women in Europe from the beginning of the eighteenth century that pushes women’s history beyond national studies to create an integrated view of three hundred years of women in Europe...... as exploring cultural perceptions of women and the ways in which women have been have been represented by these discourses. It explicitly engages with how women contributed as practitioners to shaping the culture and society of western Europe. The geographical range and generational breadth of this study...... provides a cohesive vision of women’s lives up to the present day. Women in European Culture and Society is an invaluable and essential guide to the conditions, circumstances and understandings of how women lived throughout Europe....

Changing Anthropology, Changing Society

Science.gov (United States)

Varughese, Heather

2009-01-01

Fifty years after the founding of the field of medical anthropology, the Society for Medical Anthropology of the American Anthropological Association held its first independent meeting on September 24-27, 2009, at Yale University. PMID:20027281

A Study of Marketing Strategy in the Information Society

OpenAIRE

高谷, 和夫; Kazuo, Takaya; 人間社会学部社会情報学科

2007-01-01

Most theories of marketing strategy had been studied and advocated in the industrial society. In this article, you can find the background of best-selling products based on the theory where the marketing strategy in the information society is totally different from the industrial society. Considering consumer needs and competitive advantage, attention, positioning and designing strategies have been found to be most effective in the information society.

Cryptozoology Society

Science.gov (United States)

Richman, Barbara T.

Reports of Loch Ness monsters, Bigfoot, and the Yeti spring u p from time to time, sparking scientific controversy about the veracity of these observations. Now an organization has been established to help cull, analyze, and disseminate information on the alleged creatures. The International Society of Cryptozoology, formed at a January meeting at the U.S. National Museum of Natural History of the Smithsonian Institution, will serve as the focal point for the investigation, analysis, publication, and discussion of animals of unexpected form or size or of unexpected occurrences in time or space.

Governing Civil Society Organisations and Constructing the Common Good

DEFF Research Database (Denmark)

Hein Jessen, Mathias

This paper argues that civil society is something that must be produced and constructed in order to come into existence. This construction entails a specific production of what civil society is, which values are (and should be) present in it, what the common good is and how civil society and civil...... with specific (good) values, but is at the same time instrumentalised to provide welfare services the state can and will no longer provide. Civil society, civil society organisations and the common good are not given entities, but constantly produced and mobilised in different political conjunctures....

The CERN & Society programme launches its newsletter

CERN Multimedia

Matteo Castoldi

2016-01-01

The newsletter will be issued quarterly. Sign up to remain informed about the latest initiatives of the CERN & Society programme!    The CERN & Society programme encompasses projects in the areas of education and outreach, innovation and knowledge exchange, and culture and creativity that spread the CERN spirit of scientific curiosity for the inspiration and benefit of society. The programme is funded primarily by the CERN & Society Foundation, a charitable foundation established by CERN and supported by individuals, trusts, organisations and commercial companies. The projects are inspired or enabled by CERN but lie outside of the Laboratory’s specific research mandate. We especially want to help young talent from around the world to flourish in the future. The programme is now launching its newsletter, which will be issued quarterly. Everybody who wants to be informed about CERN & Society’s activities, stay up-to-date with its latest in...

Innovation Habitat: Sustainable possibilities for the society

Directory of Open Access Journals (Sweden)

Andreia de Bem Machado

2015-12-01

Full Text Available Contemporary society is moving in the core of a reality in which sustainability needs to be thought out and inserted through practices carried out in different dimensions of society, such as organizations, public and private institutions. This paper aims to identify the contribution of innovation habitats (IH for sustainability in society. The methodology used was systematic review of scientific literature in one online database. As a result, it was identified: 47 scientific papers publicated since 2000, but more frequently in the last year, 2014, with 10 publications, without providing a reference author in the area. There was also a high number of papers about management and social sciences. It was noticed a short number of publications, empirical and theoretical, about practices to promote sustainable actions in the society, so this indicates the need of research on this kind of practices, with innovation environment as the driver.

Neuropilin 1 deficiency on CD4+Foxp3+ regulatory T cells impairs mouse melanoma growth

Science.gov (United States)

Hutzler, Marina; Abel, Simone; Alter, Christina; Stockmann, Christian; Kliche, Stefanie; Albert, Juliane; Sparwasser, Tim; Sakaguchi, Shimon; Westendorf, Astrid M.; Schadendorf, Dirk; Buer, Jan; Helfrich, Iris

2012-01-01

Infiltration of Foxp3+ regulatory T (T reg) cells is considered to be a critical step during tumor development and progression. T reg cells supposedly suppress locally an effective anti-tumor immune response within tumor tissues, although the precise mechanism by which T reg cells infiltrate the tumor is still unclear. We provide evidence that Neuropilin 1 (Nrp-1), highly expressed by Foxp3+ T reg cells, regulates the immunological anti-tumor control by guiding T reg cells into the tumor in response to tumor-derived vascular endothelial growth factor (VEGF). We demonstrate for the first time that T cell–specific ablation of Nrp-1 expression results in a significant breakdown in tumor immune escape in various transplantation models and in a spontaneous, endogenously driven melanoma model associated with strongly reduced tumor growth and prolonged tumor-free survival. Strikingly, numbers of tumor-infiltrating Foxp3+ T reg cells were significantly reduced accompanied by enhanced activation of CD8+ T cells within tumors of T cell–specific Nrp-1–deficient mice. This phenotype can be reversed by adoptive transfer of Nrp-1+ T reg cells from wild-type mice. Thus, our data strongly suggest that Nrp-1 acts as a key mediator of Foxp3+ T reg cell infiltration into the tumor site resulting in a dampened anti-tumor immune response and enhanced tumor progression. PMID:23045606

xdamp Version 6 : an IDL-based data and image manipulation program.

Energy Technology Data Exchange (ETDEWEB)

Ballard, William Parker

2012-04-01

The original DAMP (DAta Manipulation Program) was written by Mark Hedemann of Sandia National Laboratories and used the CA-DISSPLA{trademark} (available from Computer Associates International, Inc., Garden City, NY) graphics package as its engine. It was used to plot, modify, and otherwise manipulate the one-dimensional data waveforms (data vs. time) from a wide variety of accelerators. With the waning of CA-DISSPLA and the increasing popularity of Unix(reg sign)-based workstations, a replacement was needed. This package uses the IDL(reg sign) software, available from Research Systems Incorporated, a Xerox company, in Boulder, Colorado, as the engine, and creates a set of widgets to manipulate the data in a manner similar to the original DAMP and earlier versions of xdamp. IDL is currently supported on a wide variety of Unix platforms such as IBM(reg sign) workstations, Hewlett Packard workstations, SUN(reg sign) workstations, Microsoft(reg sign) Windows{trademark} computers, Macintosh(reg sign) computers and Digital Equipment Corporation VMS(reg sign) and Alpha(reg sign) systems. Thus, xdamp is portable across many platforms. We have verified operation, albeit with some minor IDL bugs, on personal computers using Windows 7 and Windows Vista; Unix platforms; and Macintosh computers. Version 6 is an update that uses the IDL Virtual Machine to resolve the need for licensing IDL.

Man in Society

Institute of Scientific and Technical Information of China (English)

单祝堂

1994-01-01

Men usually want to have their own way.They want to thinkand act as they like.No one,however,can have his own way all thetime.A man cannot live in society without considering the interestsof others as well as his own interests.’Society’ means a groupof people with the same laws and the same way of life.People in

Support Science by Publishing in Scientific Society Journals.

Science.gov (United States)

Schloss, Patrick D; Johnston, Mark; Casadevall, Arturo

2017-09-26

Scientific societies provide numerous services to the scientific enterprise, including convening meetings, publishing journals, developing scientific programs, advocating for science, promoting education, providing cohesion and direction for the discipline, and more. For most scientific societies, publishing provides revenues that support these important activities. In recent decades, the proportion of papers on microbiology published in scientific society journals has declined. This is largely due to two competing pressures: authors' drive to publish in "glam journals"-those with high journal impact factors-and the availability of "mega journals," which offer speedy publication of articles regardless of their potential impact. The decline in submissions to scientific society journals and the lack of enthusiasm on the part of many scientists to publish in them should be matters of serious concern to all scientists because they impact the service that scientific societies can provide to their members and to science. Copyright © 2017 Schloss et al.

NAHDLATUL ULAMA (NU SEBAGAI CIVIL SOCIETY DI INDONESIA

Directory of Open Access Journals (Sweden)

Esty Ekawati

2016-12-01

Full Text Available Civil Society is non-government organization or an autonomous group which is faced with state and has a function for check and balance for the government policy. Civil society also has a function to social control. Lary Diamond said that civil society establish on cultural organization such as religion or ethnic or organization which keep the truth and believe. Nahdhatul Ulama is a religion organization in Indonesia which has function to social control for the government. Beside that, the activities of NU in education, democracy development and other social activities made NU still exist in social and political society in Indonesia.

The 30 Years of the Korean Society for Nondestructive Testing

International Nuclear Information System (INIS)

2010-05-01

The contents of this book are development of nondestructive testings; the origin of nondestructive testing, history of Korea on nondestructive testing and present condition of nondestructive testing in Korea, history of society, activity of society; structure and activity of society, publication of society academic project, educational work, international exchange, and the future and direction of development of the Korean society for nondestructive testing.

Michel Foucault and the Forces of Civil Society

DEFF Research Database (Denmark)

Villadsen, Kaspar

2016-01-01

, presenting civil society as a ‘reality that does not exist’ but still has real effects. This new reality holds contradictory potentials. When articulated by political eschatology, civil society supports prophecies of the end of politics in a final accord where contradictions dissolve and the community...... absorbs the state. Neoliberal notions of civil society promise, on Foucault’s account, a more open-ended milieu of subject formation....

Technological sciences society of the twenty-first century

International Nuclear Information System (INIS)

1999-04-01

This book introduces information-oriented society of the twenty-first century connected to computer network for example memory of dream : F-ram, information-oriented society : New media, communications network for next generation ; ISDN on what is IDSN?, development of information service industry, from office automation to an intelligent building in the future, home shopping and home banking and rock that hinders information-oriented society.

Is Soviet society fit for the nuclear age

International Nuclear Information System (INIS)

Kemeny, L.G.

1986-01-01

The author argues that the Kremlin's handling of the Chernobyl crisis is a far greater indictment of Soviet ethos, society and ideology than their technology. The Soviet nuclear plan is seen to be to press on regardless of safety standards. Australia's government and society, through poor education, foreign disinformation and media orchestration, are unable to participate effectively in the responsibilities of a global nuclear society

CD4+ CD25+ CD127low Regulatory T Cells as Indicator of Rheumatoid Arthritis Disease Activity.

Science.gov (United States)

Khattab, Sahar S; El-Saied, Amany M; Mohammed, Rehab A; Mohamed, Eman E

2016-06-01

Rheumatoid arthritis (RA) is an autoimmune disease characterized by disturbed immune regulation, inducing a progressive cartilage and bone destruction. Despite enrichment of T regulatory cell (T-regs) in synovial fluid, conflicting results are reported concerning T-regs in peripheral blood (PB) of RA patients. To determine possible correlation between the frequency of PB CD4+ CD25+CD127low (T-regs) with RA disease activity. Forty females with RA, classified according to the Disease Activity Score 28 (DAS-28), as highly active, mild-moderate or low disease activity; and 20 age and sex matched healthy controls, were enrolled to study CD4+ CD25+ CD127low T- regs in PB by flow cytometry. Active RA patients had lower frequency of the CD4+ CD25+ CD127low T- regs compared to those with mild-moderate or low disease activity (P <0.001). The frequencies of the T- regs showed negative correlation with the DAS-28 (P<0.01). In conclusion, CD4+ CD25+ CD127low T-regs is significantly lower in highly active RA patients compared to patients with lower activity or controls. Copyright© by the Egyptian Association of Immunologists.

Who's making global civil society: philanthropy and US empire in world society.

Science.gov (United States)

Vogel, Ann

2006-12-01

Theories of US hegemony commonly ignore the role of American philanthropy in the contemporary transformations of world society and the globalization of capitalism. In this essay, I suggest that the philanthropic foundation, and with it the institution of philanthropy, is being invigorated by the expansion of its domestic role to foreign activities and to globally framed activities within the USA. I propose that US philanthropy exports American understandings of democracy and simultaneously organizes global reflexivity through citizenship education for the US populace. I offer a preliminary theoretical interpretation of the empirical patterns of international grant-making activities by US foundations, considering John W. Meyer's concept of 'instrumental culture' and some arguments made by Foucauldian 'governmentality' scholars. I emphasize the need to conceptualize the cultural-symbolic and organizational dimensions of hegemony and suggest further sociological analysis of philanthropic activities as integral to current politically and economically led transformations of societies around the globe.

Management of patients with refractory angina: Canadian Cardiovascular Society/Canadian Pain Society joint guidelines.

Science.gov (United States)

McGillion, Michael; Arthur, Heather M; Cook, Allison; Carroll, Sandra L; Victor, J Charles; L'allier, Philippe L; Jolicoeur, E Marc; Svorkdal, Nelson; Niznick, Joel; Teoh, Kevin; Cosman, Tammy; Sessle, Barry; Watt-Watson, Judy; Clark, Alexander; Taenzer, Paul; Coyte, Peter; Malysh, Louise; Galte, Carol; Stone, James

2012-01-01

Refractory angina (RFA) is a debilitating disease characterized by cardiac pain resistant to conventional treatments for coronary artery disease including nitrates, calcium-channel and β-adrenoceptor blockade, vasculoprotective agents, percutaneous coronary interventions, and coronary artery bypass grafting. The mortality rate of patients living with RFA is not known but is thought to be in the range of approximately 3%. These individuals suffer severely impaired health-related quality of life with recurrent and sustained pain, poor general health status, psychological distress, impaired role functioning, and activity restriction. Effective care for RFA sufferers in Canada is critically underdeveloped. These guidelines are predicated upon a 2009 Canadian Cardiovascular Society (CCS) Position Statement which identified that underlying the problem of RFA management is the lack of a formalized, coordinated, interprofessional strategy between the cardiovascular and pain science/clinical communities. The guidelines are therefore a joint initiative of the CCS and the Canadian Pain Society (CPS) and make practice recommendations about treatment options for RFA that are based on the best available evidence. Concluding summary recommendations are also made, giving direction to future clinical practice and research on RFA management in Canada. Copyright © 2012 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved.

The open society and its enemies

CERN Document Server

Popper, Karl Raimund

2003-01-01

Written in political exile during the Second World War and first published in 1945, Karl Popper's The Open Society and Its Enemies is one of the most influential books of the twentieth century. Hailed by Bertrand Russell as a 'vigorous and profound defence of democracy', its now legendary attack on the philosophies of Plato, Hegel and Marx exposed the dangers inherent in centrally planned political systems. Popper's highly accessible style, his erudite and lucid explanations of the thought of great philosophers and the recent resurgence of totalitarian regimes around the world are just three of the reasons for the enduring popularity of The Open Society and Its Enemies, and for why it demands to be read both today and in years to come. This is the second of two volumes of The Open Society and Its Enemies.

Sir Ronald A. Fisher and the International Biometric Society.

Science.gov (United States)

Billard, Lynne

2014-06-01

The year 2012 marks the 50th anniversary of the death of Sir Ronald A. Fisher, one of the two Fathers of Statistics and a Founder of the International Biometric Society (the "Society"). To celebrate the extraordinary genius of Fisher and the far-sighted vision of Fisher and Chester Bliss in organizing and promoting the formation of the Society, this article looks at the origins and growth of the Society, some of the key players and events, and especially the roles played by Fisher himself as the First President. A fresh look at Fisher, the man rather than the scientific genius is also presented. © 2014, The International Biometric Society.

Health and social research in multiethnic societies

National Research Council Canada - National Science Library

Nazroo, James Y

2006-01-01

... in Multiethnic Societies provides essential and clear guidance on appropriate methods. Topics covered include: * * * * * * approaches to conceptualising ethnicity and understanding the context of ethnicity in modern societies ethical issues and the political context within which conducted how researchers could engage with communities and with service u...

Financing Agricultural Enterprises By Cooperative Societies In ...

African Journals Online (AJOL)

The study was on cooperative societies financing of agricultural enterprises in Mbaise Area of Imo State, Nigeria. The objectives includes, identification of sources of finance for the cooperative societies and types of agricultural enterprises financed, profitability of the enterprises and the members or loan beneficiaries ...

Technology and society building our sociotechnical future

CERN Document Server

Wetmore, Jameson M

2009-01-01

Technological change does not happen in a vacuum; decisions about which technologies to develop, fund, market, and use engage ideas about values as well as calculations of costs and benefits. This anthology focuses on the interconnections of technology, society, and values. It offers writings by authorities as varied as Freeman Dyson, Laurence Lessig, Bruno Latour, and Judy Wajcman that will introduce readers to recent thinking about technology and provide them with conceptual tools, a theoretical framework, and knowledge to help understand how technology shapes society and how society shapes technology. It offers readers a new perspective on such current issues as globalization, the balance between security and privacy, environmental justice, and poverty in the developing world. The careful ordering of the selections and the editors' introductions give Technology and Society a coherence and flow that is unusual in anthologies. The book is suitable for use in undergraduate courses in STS and other disciplines...

5th Physics and Society Forum - EPS

CERN Multimedia

2012-01-01

The Fifth Physics and Society Forum, organized by the European Physical Society, will take place at CERN from 28 to 29 March 2012. 
The purpose of the meeting is to explore the challenges experienced by physicists who leave their field of study to pursue alternative careers in the market place outside of teaching and university-based research. 
     It is widely recognized that a knowledgeable society is a prerequisite for growth. Value is only created if knowledge can be transformed into know-how and "know-how-to-do". Today it is widely recognized that a society is unable to grow and sustain an advanced science system unless equally advanced production is present. Today production is off-shored to emerging economies in Asia and elsewhere where labour costs are more favourable. European physicists therefore have the choice of being smarter, working harder and working cheaper or moving into other fields. 

 Registration is open until 1st March 2012. Please ...

The Society of Thoracic Surgeons, The Society of Cardiovascular Anesthesiologists, and The American Society of ExtraCorporeal Technology: Clinical Practice Guidelines-Anticoagulation During Cardiopulmonary Bypass.

Science.gov (United States)

Shore-Lesserson, Linda; Baker, Robert A; Ferraris, Victor A; Greilich, Philip E; Fitzgerald, David; Roman, Philip; Hammon, John W

2018-02-01

Despite more than a half century of "safe" cardiopulmonary bypass (CPB), the evidence base surrounding the conduct of anticoagulation therapy for CPB has not been organized into a succinct guideline. For this and other reasons, there is enormous practice variability relating to the use and dosing of heparin, monitoring heparin anticoagulation, reversal of anticoagulation, and the use of alternative anticoagulants. To address this and other gaps, The Society of Thoracic Surgeons, the Society of Cardiovascular Anesthesiologists, and the American Society of Extracorporeal Technology developed an Evidence Based Workgroup. This was a group of interdisciplinary professionals gathered to summarize the evidence and create practice recommendations for various aspects of CPB. To date, anticoagulation practices in CPB have not been standardized in accordance with the evidence base. This clinical practice guideline was written with the intent to fill the evidence gap and to establish best practices in anticoagulation therapy for CPB using the available evidence. To identify relevant evidence, a systematic review was outlined and literature searches were conducted in PubMed using standardized medical subject heading (MeSH) terms from the National Library of Medicine list of search terms. Search dates were inclusive of January 2000 to December 2015. The search yielded 833 abstracts, which were reviewed by two independent reviewers. Once accepted into the full manuscript review stage, two members of the writing group evaluated each of 286 full papers for inclusion eligibility into the guideline document. Ninety-six manuscripts were included in the final review. In addition, 17 manuscripts published before 2000 were included to provide method, context, or additional supporting evidence for the recommendations as these papers were considered sentinel publications. Members of the writing group wrote and developed recommendations based on review of the articles obtained and achieved

The Mediated Transparent Society

DEFF Research Database (Denmark)

Backer, Lise

2001-01-01

in the mediated transparent society. The paper concludes that, based on these analyses, the mediated panopticism working on the business segment is not an effective disciplinary apparatus, which can guarantee that business corporations are carrying out important ecological or ethical improvements....

Expression and localization of regenerating gene I in a rat liver regeneration model

International Nuclear Information System (INIS)

Wang Jingshu; Koyota, Souichi; Zhou, Xiaoping; Ueno, Yasuharu; Ma Li; Kawagoe, Masami; Koizumi, Yukio; Okamoto, Hiroshi; Sugiyama, Toshihiro

2009-01-01

Regenerating gene (Reg) I has been identified as a regenerative/proliferative factor for pancreatic islet cells. We examined Reg I expression in the regenerating liver of a rat model that had been administered 2-acetylaminofluorene and treated with 70% partial hepatectomy (2-AAF/PH model), where hepatocyte and cholangiocyte proliferation was suppressed and the hepatic stem cells and/or hepatic progenitor cells were activated. In a detailed time course study of activation of hepatic stem cells in the 2-AAF/PH model, utilizing immunofluorescence staining with antibodies of Reg I and other cell-type-specific markers, we found that Reg I-expressing cells are present in the bile ductules and increased during regeneration. Reg I-expressing cells were colocalized with CK19, OV6, and AFP. These results demonstrate that Reg I is significantly upregulated in the liver of the 2-AAF/PH rat model, accompanied by the formation of bile ductules during liver regeneration.

Open source, collectivism, and Japanese society

OpenAIRE

Iitaka, Toshikazu

2010-01-01

This paper is about collectivism in the Network Society. Many researches about the Network Society evaluate collectivism, citing Japanese culture and Hacker culture as good models of such collectivism. However, some researchers, such as K. Abe in his analysis of “Seken,” criticize Japanese collectivism. Abe’s study pointed out the negative effect of Japanese collectivism on scientific progress. This paper will criticize Abe’s study and offer a new model for evaluating collec...

Science-Technology-Society or Technology-Society-Science? Insights from an Ancient Technology

Science.gov (United States)

Lee, Yeung Chung

2010-01-01

Current approaches to science-technology-society (STS) education focus primarily on the controversial socio-scientific issues that arise from the application of science in modern technology. This paper argues for an interdisciplinary approach to STS education that embraces science, technology, history, and social and cultural studies. By employing…

The first joint congress of the South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology at the University of the Witwatersrand, 29 June-4 July 1986

International Nuclear Information System (INIS)

1986-01-01

The South African Biochemical Society, South African Genetics Society and the South African Society for Microbiology held a joint congress at the University of the Witwatersrand from 29 June - 4 July 1986. The papers delivered cover subjects such as Molecular biology, Genetics, Biochemistry, Medical biochemistry, Physiology, Zoology and Isotope and radiation sciences. Different isotopes are used in labelling studies of enzymes, nutrition, metabolism, viruses, bacteria and other biological assays done in the fields of Biochenmistry, Genetics and Microbiology. This work contains only the abstracts of these papers

Emerging Information Societies in an Interdependent World.

Science.gov (United States)

Bernasconi, F. A.

Commenting on the trends toward the interlocking of emerging information societies and the growing interdependence of countries, this paper suggests the role that "informatics" (the rational and systematic use of information for planning and decision making) may play in the transition of societies into the information age. Two paradoxes…

Myth and Other Norms in World Society

DEFF Research Database (Denmark)

Petersen, Hanne

2016-01-01

This article uses the Thule Case at the Danish Supreme Court as an example of normativity in world society. Here norms, which may turn out to be important in world society could be myths of several kinds such as 'narrative normativity'. One myth may be that of (exclusive) sovereignty...

Politics, Society and Communication in the Constitution of Modern Society: Early Modern England

Directory of Open Access Journals (Sweden)

Devrim ÖZKAN

2014-12-01

Full Text Available The inception of Modern England comprises a hundred and fifty years between sixteenth and mid eighteenth centuries. The structural qualities of modern societies of this day occur in this era. The political and economic changes and transformations that England experienced in this period of time are in enormous scale. In this period all social structure and institutions experienced structural change in terms of cultural, economic and political processes. In addition to this in this period the framework of the international system regarding economy and politics is established too. Important qualities of current modern societies are the speed of communication and interaction between its elements, its transformational capacity and the extent of its scope. In this, it is possible to apprehend the basic cornerstones of today’s information and communication age by analyzing the early modern period of England

Applying consensus standards to cask development

International Nuclear Information System (INIS)

Leatham, J.; Abbott, D.G.; Warrant, M.M.

1987-01-01

The Department of Energy's (DOE's) Office of Civilian Radioactive Waste Management is procuring cask systems for transporting commercial spent nuclear fuel and is encouraging development of innovative cask designs and materials to improve system efficiency. New designs and innovative materials require that consensus standards be established so that cask designers and regulators have criteria for determining acceptability. Recent DOE experience in certifying three spent fuel shipping casks, NUPAC-125B, TN-BRP, and TN-REG, is discussed. Certification of the NUPAC-125B was expedited because it was made of conventional American Society for Testing and Materials (ASTM) materials and complied with the American Society of Mechanical Engineers (ASME) Code and Nuclear Regulatory Commission Regulatory Guides. The TN-BRP and TN-REG cask designs are still being reviewed because baskets included in the casks are made of borated stainless steel, which has no ASTM Specification or ASME Code approval. The process of developing and approving consensus standards is discussed, including the role of ANSI and ANSI N14. Specific procedures for ASTM and ASME are described. A draft specification or standard must be prepared and then approved by the appropriate body. For new material applications to the ASME Code, an existing ASTM Specification is needed. These processes may require several years. The status of activities currently in progress to develop consensus standards for spent fuel casks is discussed, including (1) ASME NUPAC, and (2) ASTM Specifications for ductile cast iron and borated stainless steel

The Good Society: Lessons for Integrated Governance

Directory of Open Access Journals (Sweden)

Neesham C.

2009-12-01

Full Text Available In this paper I argue that philosophies of the good society can inform theories of integrated governance in two significant ways. Firstly, they can provide a reasonable foundation for legitimating forms of authority to govern a society across the government, corporate and civil sector. Secondly, they promote value systems that can be constitutive of a normative theory of integrated governance. In developing this argument, I explore conceptions of the good society put forward by Marquis de Condorcet, Adam Smith and Karl Marx, and evaluate the modalities in which the social projects proposed by these authors involve issues of integrated governance. For this purpose, I examine the three theories in relation to three questions: (1 What goals (or objectives should social action be directed to? (2 What should be the scope and limits of social responsibility lying behind the social authority of each sector (government, market or civil society? (3 How is social authority to be exercised beyond legislation? What source(s of legitimacy should one appeal to? Although Condorcet’s idea of the natural social order, Smith’s system of natural liberty and Marx’s political economy of human value have all received their fair share of criticism from empirical theories of society, I suggest that these conceptions are still useful to us today as radical normative experiments. These experiments can have guiding value in formulating models of integrated governance. However, the fundamental differences displayed by these three conceptions reveal the importance of determining whether one can develop models of integrated governance that would accommodate plural, incompatible, or unknown conceptions of the good society.

Institutions of Civil Society Participating in Public Relations

Directory of Open Access Journals (Sweden)

Olga S. Belokrylova

2016-12-01

Full Text Available The degree of maturity of the civil society of a country is now seen as an important indicator of the development of a socially oriented market economy. The authors explore two forms of state and civil society relations - qualitative, characterized by the diffusion of a relationship of trust in society, and quantitative, in the system of public procurement corruption identifiable pace of localization. Institutional capacity development of civil society in public relations is the simultaneous modernization of the qualitative and quantitative scope of its relationship with the state. The paper presents the mechanism of transition to a partnership model relations between the state and civil society, the most important form of which is the realization of public control, rapid formal institutionalization which has provided detection and elimination of large-scale irregularities in public procurement. Its swift formal institutionalization provided by representatives of civil society to identify and eliminate large-scale irregularities in public procurement. The experience of NGO Fund "Sodeistvie - XXI vek" to identify "blind" purchases, is offered as a tool to improve the efficiency of public control conduct free training of potential public controlles by institutions engaged in training of civil officials for the course "Management of state and municipal procurement".

America's Scholarly Societies Raise Their Flags Abroad.

Science.gov (United States)

McMurtrie, Beth

2000-01-01

Reports that greater numbers of scholarly societies, though American in name, are increasingly international in membership and outlook. Suggests that this trend has been driven by the expanding global outlook of scholars, the collapse of communism, and growth of the Internet. Efforts to encourage local professional societies, fears of American…

Autonomy and Liberalism in a Multicultural Society

Science.gov (United States)

Jewell, Paul

2005-01-01

That children should be educated to be ideal citizens, capable of making rational and informed decisions, has been proposed in cultures ranging from Ancient Greece to current societies. In particular, societies that favour liberalism preach the primacy of the individual autonomous citizen and a concomitant tolerance for others. In modern…

The Resilient Society: On volunteering, civil society and corporate community involvement in transition

NARCIS (Netherlands)

L.C.P.M. Meijs (Lucas)

2004-01-01

textabstractChanges in the Dutch non-profit regime necessitate the direct participation of citizens and businesses in non-profit organisations. Dutch society must re-invent the commitment of citizens, businesses, foundations, universities and various other organisations by increasing both ‘community

Mineral resources of Peru's ancient societies

Science.gov (United States)

Brooks, W.E.

2003-01-01

Northern Peru has an exceptionally rich archaeological heritage that includes metalwork, ceramics and textiles. The success of at least a half-dozen pre-Columbian societies dating back 3,000 years and subsequent Spanish colonization in the 1400s has rested on the effective use of northern Peru's abundant resources. In the summer of 2000, my son Matt and I learned about that connection firsthand by volunteering at the Santa Rita B archaeological site in the Chao Valley near Trujillo in northern Peru. Riding donkey-back through the Andes and talking with local people, we got our hands dirty in the rich archaeology and geology of the area. We were able to correlate mineral occurrences to their various roles in society - opening a window into the region's fascinating past. From construction to metallurgy, pre-Columbian societies flourished and advanced because of their understanding and use of the available mineral resources.

Masa depan civil society di Indonesia: prospek dan tantangan

Directory of Open Access Journals (Sweden)

Halili Halili

2015-10-01

Full Text Available This paper aims to discuss on civil society, its prospects and challenges. It is urgent because civil society is a determining factor of lndonesia democratization. Civil society is a society within state which containing social association which has ability to fill public spaces between state and citizen, and interactwith state independt1y, wether indivual or collective. Prospect qf civil societyfarming is determined by establishment ofsome components: 1 existence cf societal autonomy, 2 access ofpublic to state agencies, 3 independent public arena; 4 arena publik yang mandiri, dan keempat arena publik yang terbuka. Prospect of ciuil society deuelopmentis influenced by optimalization ofsome factors: 1 establishment of, demo­cratic families, 2 growth of roles of non government organization toward both state and citizen, 3 increase of intellectual middle class, especially students, and 4 implementation of political education formally (e.g. civic or citizenship education and informally. The challenges of future of civil society are: 1 high of social fragmentation among people, 2 limited distribution of development results infold ofeconomy, social, and education, and also 4 paternalistic culture which is stiO strong among society.

American Nuclear Society exchanges of information

International Nuclear Information System (INIS)

Du Temple, O.J.

2000-01-01

Many are familiar with the technical journals and other publications that American Nuclear Society (ANS) members receive. However, there is a whole series of documents that is helpful to any nuclear society group for a modest fee or no fee. The author is referring to documents such as the ANS Bylaws and Rules, which have been made available to almost every existing nuclear society in the world. He remembers working with groups from Russia, Europe, China, Japan, Brazil, France, Germany, and others when they sought the experience of ANS in establishing a society. Financial planning guides are available for meetings, international conferences, technical expositions, and teacher workshops. Periodically, the ANS publishes position papers on the uses and handling of fuel materials and other publications helpful to public relations and teacher training courses. A few have had distributions in the hundreds of thousands, and one went as high as 750,000. Some of these have been translated in part into Spanish, French, Portuguese, and Japanese. Nuclear Standards are developed by a series of ANS committees consisting of about 1000 experts--the largest technical operation of ANS. Buyers guides and directories are very helpful in promoting the commerce in the nuclear industry. The Utility Directory covers utilities all over the globe. Radwaste Solutions, the new name for the former Radwaste Magazine, covers the efforts made by all sectors--private, government, and utility--to deal with radioactive waste. In the author's opinion, the one area in which all societies are weak is in interfacing with the International Atomic Energy Agency (IAEA). Since his retirement 9 yr ago, he has become much more aware of the IAEA as a news and technical information source. The ANS is trying to be more aware of what the IAEA is doing for everyone

ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease: A Report of the American College of Cardiology Appropriate Use Criteria Task Force, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons.

Science.gov (United States)

Doherty, John U; Kort, Smadar; Mehran, Roxana; Schoenhagen, Paul; Soman, Prem; Dehmer, Greg J; Doherty, John U; Schoenhagen, Paul; Amin, Zahid; Bashore, Thomas M; Boyle, Andrew; Calnon, Dennis A; Carabello, Blase; Cerqueira, Manuel D; Conte, John; Desai, Milind; Edmundowicz, Daniel; Ferrari, Victor A; Ghoshhajra, Brian; Mehrotra, Praveen; Nazarian, Saman; Reece, T Brett; Tamarappoo, Balaji; Tzou, Wendy S; Wong, John B; Doherty, John U; Dehmer, Gregory J; Bailey, Steven R; Bhave, Nicole M; Brown, Alan S; Daugherty, Stacie L; Dean, Larry S; Desai, Milind Y; Duvernoy, Claire S; Gillam, Linda D; Hendel, Robert C; Kramer, Christopher M; Lindsay, Bruce D; Manning, Warren J; Mehrotra, Praveen; Patel, Manesh R; Sachdeva, Ritu; Wann, L Samuel; Winchester, David E; Wolk, Michael J; Allen, Joseph M

2018-04-01

This document is 1 of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. This document addresses the evaluation and use of multimodality imaging in the diagnosis and management of valvular heart disease, whereas the second, companion document addresses this topic with regard to structural heart disease. Although there is clinical overlap, the documents addressing valvular and structural heart disease are published separately, albeit with a common structure. The goal of the companion AUC documents is to provide a comprehensive resource for multimodality imaging in the context of valvular and structural heart disease, encompassing multiple imaging modalities. Using standardized methodology, the clinical scenarios (indications) were developed by a diverse writing group to represent patient presentations encountered in everyday practice and included common applications and anticipated uses. Where appropriate, the scenarios were developed on the basis of the most current American College of Cardiology/American Heart Association guidelines. A separate, independent rating panel scored the 92 clinical scenarios in this document on a scale of 1 to 9. Scores of 7 to 9 indicate that a modality is considered appropriate for the clinical scenario presented. Midrange scores of 4 to 6 indicate that a modality may be appropriate for the clinical scenario, and scores of 1 to 3 indicate that a modality is considered rarely appropriate for the clinical scenario. The primary objective of the AUC is to provide a framework for the assessment of these scenarios by practices that will

Science, Society and Policy

Science.gov (United States)

White, K. S.; Teich, A. H.

2010-12-01

Apart from the journals they produce, scientific societies play an important role in communicating scientific findings and norms to the broader society. The American Association for the Advancement of Science (AAAS) includes among its goals to promote and defend the integrity of science and its use; provide a voice for science on societal issues; promote the responsible use of science in public policy; and increase public engagement with science and technology. AAAS websites and programs, including Communicating Science (www.aaas.org/communicatingscience), Working with Congress (http://www.aaas.org/spp/cstc/wwc/book.htm) and ScienceCareers.org (http://sciencecareers.sciencemag.org), provide tools for scientists to become more directly engaged in effectively communicating their findings and involved in the policy process. Education programs work to build the next generation of scientists and a science-literate public. To bridge the current communication gap between scientists, the public and policymakers, AAAS, like other scientific societies, maintains policy and outreach programs with limited budgets and staff. AAAS works to engage policymakers and provide scientific underpinning to key issues through congressional briefings, meetings, policy briefs, and media outreach. AAAS responds to challenges to accepted scientific findings and processes through op-eds, letters to government officials, resolutions, and Board statements. Some of these initiatives occur on a local level in partnership with local civic leaders, whose endorsement makes them more powerful. On a national scale, they assure that the voice of science is included in the debate. The changing media landscape presents opportunities and challenges for future AAAS endeavors.

Representation of monsoon intraseasonal oscillations in regional climate model: sensitivity to convective physics

KAUST Repository

Umakanth, U.; Kesarkar, Amit P.; Attada, Raju; Vijaya Bhaskar Rao, S.

2015-01-01

combinations of Grell (G) and Emanuel (E) cumulus schemes namely, RegCM-EG, RegCM-EE and RegCM-GE have been used. The model is initialized at 1st January, 2000 for a 13-year continuous simulation at a spatial resolution of 50 km. The models reasonably simulate

Methods of Conflict Resolution in African Traditional Society | Ajayi ...

African Journals Online (AJOL)

This study examined the patterns or mechanism for conflict resolution in traditional African societies with particular reference to Yoruba and Igbo societies in Nigeria and Pondo tribe in South Africa. The paper notes that conflict resolution in traditional African societies provides opportunity to interact with the parties ...

Association of peripheral NK cell counts with Helios+ IFN-γ- Tregs in patients with good long-term renal allograft function.

Science.gov (United States)

Trojan, K; Zhu, L; Aly, M; Weimer, R; Bulut, N; Morath, C; Opelz, G; Daniel, V

2017-06-01

Little is known about a possible interaction of natural killer (NK) cells with regulatory T cells (T reg ) in long-term stable kidney transplant recipients. Absolute counts of lymphocyte and T reg subsets were studied in whole blood samples of 136 long-term stable renal transplant recipients and 52 healthy controls using eight-colour fluorescence flow cytometry. Patients were 1946 ± 2201 days (153-10 268 days) post-transplant and showed a serum creatinine of 1·7 ± 0·7 mg/dl. Renal transplant recipients investigated > 1·5 years post-transplant showed higher total NK cell counts than recipients studied express the phenotype Helios + interferon (IFN)-γ - and appear to have stable FoxP3 expression and originate from the thymus. Furthermore, high total NK cells were associated with T reg that co-express the phenotypes interleukin (IL)-10 - transforming growth factor (TGF)-β + (P = 0·013), CD183 + CD62L - (P = 0·003), CD183 + CD62 + (P = 0·001), CD183 - CD62L + (P = 0·002), CD252 - CD152 + (P term good allograft function and the statistical association of these two lymphocyte subsets with each other suggest a direct or indirect (via DC) interaction of these cell subpopulations that contributes to good long-term allograft acceptance. Moreover, we speculate that regulatory NK cells are formed late post-transplant that are able to inhibit graft-reactive effector cells. © 2017 British Society for Immunology.

Eosinophils from eosinophilic oesophagitis patients have T cell suppressive capacity and express FOXP3.

Science.gov (United States)

Lingblom, C; Wallander, J; Ingelsten, M; Bergquist, H; Bove, M; Saalman, R; Welin, A; Wennerås, C

2017-03-01

Eosinophilic esophagitis (EoE) is an antigen-driven T cell-mediated chronic inflammatory disease where food and environmental antigens are thought to have a role. Human eosinophils express the immunoregulatory protein galectin-10 and have T cell suppressive capacity similar to regulatory T cells (T regs ). We hypothesized that one function of eosinophils in EoE might be to regulate the T cell-driven inflammation in the oesophagus. This was tested by evaluating the suppressive capacity of eosinophils isolated from the blood of adult EoE patients in a mixed lymphocyte reaction. In addition, eosinophilic expression of forkhead box protein 3 (FOXP3), the canonical transcription factor of T regs , was determined by conventional and imaging flow cytometry, quantitative polymerase chain reaction (qPCR), confocal microscopy and immunoblotting. It was found that blood eosinophils from EoE patients had T cell suppressive capacity, and that a fraction of the eosinophils expressed FOXP3. A comparison of EoE eosinophils with healthy control eosinophils indicated that the patients' eosinophils had inferior suppressive capacity. Furthermore, a higher percentage of the EoE eosinophils expressed FOXP3 protein compared with the healthy eosinophils, and they also had higher FOXP3 protein and mRNA levels. FOXP3 was found in the cytosol and nucleus of the eosinophils from both the patients and healthy individuals, contrasting with the strict nuclear localization of FOXP3 in T regs . To conclude, these findings suggest that the immunoregulatory function of eosinophils may be impaired in EoE. © 2016 British Society for Immunology.

Data science and digital society

Directory of Open Access Journals (Sweden)

Chen Cathy Yi-Hsuan

2017-07-01

Full Text Available Data Science looks at raw numbers and informational objects created by different disciplines. The Digital Society creates information and numbers from many scientific disciplines. The amassment of data though makes is hard to find structures and requires a skill full analysis of this massive raw material. The thoughts presented here on DS2 - Data Science & Digital Society analyze these challenges and offers ways to handle the questions arising in this evolving context. We propose three levels of analysis and lay out how one can react to the challenges that come about. Concrete examples concern Credit default swaps, Dynamic Topic modeling, Crypto currencies and above all the quantitative analysis of real data in a DS2 context.

Information Society for the South | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

Recognizing that ICTs and the information society have far-reaching ... Researchers will examine the information society with respect to three key domains: social ... Reflections about media, violence, identity and representation through an ...

MARX EMBRYOLOGY OF SOCIETY

NARCIS (Netherlands)

WOUTERS, A

This article presents a new interpretation of Marx's dialectical method. Marx conceived dialectics as a method for constructing a model of society. The way this model is developed is analogous to the way organisms develop according to the German embryologist Karl Ernst von Baer, and, indeed, Marx's

Afghanistan, state and society

DEFF Research Database (Denmark)

Kværnø, Ole

In June 2007, the RAND Corporation and the Royal Danish Defence College hosted a conference titled “Afghanistan: State and Society, Great Power Politics, and the Way Ahead”. The two-day event, held in Copenhagen, was attended by more than 100 politicians, scholars, academics, and representative...

October 2012 Arizona thoracic society notes

Directory of Open Access Journals (Sweden)

Robbins RA

2012-10-01

Full Text Available No abstract available. Article truncated at 150 words. A dinner meeting was held on 10/24/2012 at Scottsdale Shea beginning at 6:30 PM. There were 23 in attendance representing the pulmonary, critical care, sleep, infectious disease, pathology, and radiology communities. An announcement was made that the Colorado Thoracic Society has accepted an invitation to partner with the Arizona and New Mexico Thoracic Societies in the Southwest Journal of Pulmonary and Critical Care Medicine. Discussions continue to be held regarding a combined Arizona Thoracic Society meeting with Tucson either in Casa Grande or electronically. Six cases were presented: Dr. Tim Kuberski, chief of Infectious Disease at Maricopa Medical Center, presented a 48 year old female who had been ill for 2 weeks. A CT of the chest revealed a left lower lobe nodule and a CT of the abdomen showed hydronephrosis and a pelvic mass. Carcinoembryonic antigen (CEA was elevated. All turned out to be coccidioidomycosis on biopsy. CEA decreased …

Information Technology: A challenge to the Human Factors Society?

DEFF Research Database (Denmark)

Rasmussen, Jens

1988-01-01

In his presidential address at the annual meeting of the Human Factors Society, Julian Christensen urged the members of the society to spread the gospel and to persuade the members of other professional societies such as psychologists,sociologists and engineers to join the Human Factors Society......, the argument being that advanced technology requires a cross-disciplinary approach to human factors problems. In the present note, I would like to support this presidential effort. In fact, I will go further in that direction and argue that the present fast pace of information technology threatens to overrun...

21 CFR 184.1257 - Clove and its derivatives.

Science.gov (United States)

2010-04-01

... Eugenia caryophyllata Thunberg, native to tropical Asia. Their derivatives include essential oils (cloves, CAS Reg. No. 8000-34-8; buds; leaves, CAS Reg. No. 8015-97-2; stems, CAS Reg. No. 8015-98-3; and... stems. (b) Clove bud oil, clove leaf oil, clove stem oil, and eugenol meet the specifications of the...

Technological hazards in the understanding of society

International Nuclear Information System (INIS)

Diepold, W.

1977-01-01

This is a discussion of how employees of industry, an important part of society, and how the consumers and hence the whole volume of society express their attitude with respect to technological hazards in their practical activities and how the conclusions can be drawn from this that the population is thoroughly familiar in dealing with potential hazards. (orig.) [de

Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline.

Science.gov (United States)

Gordon, Catherine M; Ackerman, Kathryn E; Berga, Sarah L; Kaplan, Jay R; Mastorakos, George; Misra, Madhusmita; Murad, M Hassan; Santoro, Nanette F; Warren, Michelle P

2017-05-01

The American Society for Reproductive Medicine, the European Society of Endocrinology, and the Pediatric Endocrine Society. This guideline was funded by the Endocrine Society. To formulate clinical practice guidelines for the diagnosis and treatment of functional hypothalamic amenorrhea (FHA). The participants include an Endocrine Society-appointed task force of eight experts, a methodologist, and a medical writer. This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation approach to describe the strength of recommendations and the quality of evidence. The task force commissioned two systematic reviews and used the best available evidence from other published systematic reviews and individual studies. One group meeting, several conference calls, and e-mail communications enabled consensus. Endocrine Society committees and members and cosponsoring organizations reviewed and commented on preliminary drafts of this guideline. FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies, as FHA is a diagnosis of exclusion. A multidisciplinary treatment approach is necessary, including medical, dietary, and mental health support. Medical complications include, among others, bone loss and infertility, and appropriate therapies are under debate and investigation. Copyright © 2017 Endocrine Society

The Impact of Civil Society Organizations on Sustainable ...

African Journals Online (AJOL)

Toshiba

society organizations appear to play important role in social, political and economic ... depend on the effectiveness and efficiency of its civil societies. This ..... media provided a strong leadership and organized protests against unpopular ...

ON ANTHROPOLOGICAL PROBLEMS OF INFORMATION SOCIETY

Directory of Open Access Journals (Sweden)

Nikita Leonidovich Karavaev

2013-10-01

Full Text Available In article, the author envisages the anthropological problems of the modern information society. There is a new definition of information society, the main factor of which is the automatization of information processes. Different types of information technology impacts (informational and technological impacts on human being are considered. In addition, the author shows the primary transformation of human being due to modern information technologies, based on computer and telecommunication technique.DOI: http://dx.doi.org/10.12731/2218-7405-2013-7-17

The Digital Society and Provision of Welfare Services

DEFF Research Database (Denmark)

Pedersen, John Storm; Wilkinson, Adrian

2018-01-01

The digital society has been announced and subconsequently, the digital welfare state. The digital society and the digital welfare state changes the provision of welfare services to the citizens as end-users. The article analyses how....

Civil Society and Distributional Conflicts in Southeast Asia

DEFF Research Database (Denmark)

Schmidt, Johannes Dragsbæk

2010-01-01

focuses on the competing theoretical definitions and assumptions about civil society, democratization and social change; the second part explores the attempts by civil society actors to impact conflicts over resources and distribution of welfare in Southeast Asia; the third section focuses...... on the conflictual relationship between civil society organizations (CSOs) and the state and various types of social and labour market regulations, laws and contractual relationships, and finally the need for progressive social reform is emphasized as one important type of social resistance against the downsizing...

Reduction of regulatory T cells in skin lesions but not in peripheral blood of patients with systemic scleroderma.

Science.gov (United States)

Klein, S; Kretz, C C; Ruland, V; Stumpf, C; Haust, M; Hartschuh, W; Hartmann, M; Enk, A; Suri-Payer, E; Oberle, N; Krammer, P H; Kuhn, A

2011-08-01

To determine the frequency and suppressive capacity of regulatory T cells (T(reg)) and their association with clinical parameters in patients with systemic scleroderma (SSc). Peripheral blood from 25 patients with SSc, 15 patients with localised scleroderma (LS) and 29 healthy controls (HC) was studied. Analysis of CD4(+) forkhead box P3 (Foxp3)(+) and CD4(+)CD25(++)Foxp3(+) T(reg) subpopulations was carried out by flow cytometry and cell proliferation was quantified by (3)H-thymidine incorporation. Quantitative analysis of T(reg) was further performed in skin biopsies from 17 patients with SSc and 21 patients with LS using anti-CD4 and anti-Foxp3 monoclonal antibodies for immunohistochemistry. The frequency of CD4(+)Foxp3(+) and CD4(+)CD25(++)Foxp3(+) T(reg) in peripheral blood from patients with SSc was not significantly different from that of patients with LS or HC. The suppressive capacity of CD4(+)CD25(++) T(reg) in SSc was also found to be similar to that of HC. Phenotypic and functional data revealed no significant difference between the limited or diffuse form of SSc. Moreover, therapy with bosentan showed no significant effect on the frequency of T(reg) during the course of the disease. However, the frequency of T(reg) in skin lesions from patients with SSc or LS, determined as the percentage of CD4(+) cells expressing Foxp3 in the inflammatory infiltrate, was significantly reduced compared with other inflammatory skin diseases. These results indicate that although the authors found no defect in the frequency or function of peripheral T(reg) subpopulations, the reduction of CD4(+)Foxp3(+) T(reg) in the skin of patients with SSc may be important in the pathogenesis of the disease.

Specific central nervous system recruitment of HLA-G(+) regulatory T cells in multiple sclerosis.

Science.gov (United States)

Huang, Yu-Hwa; Zozulya, Alla L; Weidenfeller, Christian; Metz, Imke; Buck, Dorothea; Toyka, Klaus V; Brück, Wolfgang; Wiendl, Heinz

2009-08-01

We have recently described a novel population of natural regulatory T cells (T(reg)) that are characterized by the expression of HLA-G and may be found at sites of tissue inflammation (HLA-G(pos) T(reg)). Here we studied the role of these cells in multiple sclerosis (MS), a prototypic autoimmune inflammatory disorder of the central nervous system (CNS). Sixty-four patients with different types of MS, 9 patients with other neurological diseases, and 20 healthy donors were included in this study. Inflamed brain lesions from 5 additional untreated MS patients were examined. HLA-G(pos) T(reg) were analyzed in the cerebrospinal fluid (CSF) by flow cytometry and in inflammatory demyelinating lesions of MS brain specimens by immunohistochemistry. Functional capacity was accessed and transmigration was determined using an in vitro model of the human blood-brain barrier (BBB). HLA-G(pos) T(reg) were found enriched in the inflamed CSF of MS patients and in inflammatory demyelinating lesions of MS brain specimens. HLA-G(pos) T(reg) showed a strong propensity to transmigrate across BBB, which was vigorously driven by inflammatory chemokines, and associated with a gain of suppressive capacity upon transmigration. CSF-derived HLA-G(pos) T(reg) of MS patients represented a population of activated central memory activated T cells with an upregulated expression of inflammatory chemokine receptors and exhibiting full suppressive capacity. Unlike natural FoxP3-expressing T(reg), HLA-G(pos) T(reg) derived from peripheral blood were functionally unimpaired in MS. In MS, HLA-G(pos) T(reg) may serve to control potentially destructive immune responses directly at the sites of CNS inflammation and to counterbalance inflammation once specifically recruited to the CNS.

40 CFR 52.120 - Identification of plan.

Science.gov (United States)

2010-07-01

... Devices) 12-3-6(Penalty for Violation) 12-4-1(Shade, Density, or Opacity of Emissions) 12-4-2(Dust Control...) Sec. 2, Reg. 1(Shade, Density or Opacity of Emissions) Sec. 2, Reg. 2(Particulate Matter) Sec. 2, Reg...(Particulate Emissions: Portland Cement Plants) R9-3-308 (Particulate Emissions: Heater-Planers) Submitted on...

Perspectives on Regulatory T Cell Therapies.

Science.gov (United States)

Probst-Kepper, Michael; Kröger, Andrea; Garritsen, Henk S P; Buer, Jan

2009-01-01

Adoptive transfer in animal models clearly indicate an essential role of CD4+ CD25+ FOXP3+ regulatory T (T(reg)) cells in prevention and treatment of autoimmune and graft-versus-host disease. Thus, T(reg) cell therapies and development of drugs that specifically enhance T(reg) cell function and development represent promising tools to establish dominant tolerance. So far, lack of specific markers to differentiate human T(reg) cells from activated CD4+ CD25+ effector T cells, which also express FOXP3 at different levels, hampered such an approach. Recent identification of the orphan receptor glycoprotein-A repetitions predominant (GARP or LRRC32) as T(reg) cell-specific key molecule that dominantly controls FOXP3 via a positive feedback loop opens up new perspectives for molecular and cellular therapies. This brief review focuses on the role of GARP as a safeguard of a complex regulatory network of human T(reg) cells and its implications for regulatory T cell therapies in autoimmunity and graft-versus-host disease.

ABOUT THE ROMANIAN SOCIETY FOR ENGINEERING GRAPHICS

Directory of Open Access Journals (Sweden)

SIMION Ionel

2015-06-01

Full Text Available SORGING is a non-profit, non-governmental society, opened to all professionals interested in Engineering Graphics and Design. It aims to promote the research, development and innovation activities, together with the dissemination of best practices and assistance for educational purposes. In this paper the research and educational activities of the Romanian Society for Engineering Graphics will be briefly reviewed.

Ethics in the Relationship Between Science and Society

Science.gov (United States)

Wigner, Eugene P.

1972-01-01

Expresses views on relationships which should exist between scientists and society. A scientist has special obligations to inform the public of new knowledge correctly, but this does not give him any special rights over others in society. (PS)

School in the knowledge society

DEFF Research Database (Denmark)

Sørensen, Birgitte Holm; Levinsen, Karin

2011-01-01

  Implementation of ICT in Danish and Nordic schools gradually moves from an industrial towards an emerging knowledge society school paradigm. Simultaneously it, digital literacy and the school's physical and social organization are constantly negotiated. In schools that proactively meet the chal......  Implementation of ICT in Danish and Nordic schools gradually moves from an industrial towards an emerging knowledge society school paradigm. Simultaneously it, digital literacy and the school's physical and social organization are constantly negotiated. In schools that proactively meet...... the challenges new designs for teaching and learning emerge while teacher-student relations transform and the children and young people's competencies are resources in the processes of learning. The chapter present research based on the proactive schools and exemplifies possible outlines of the school...

The challenges of risk society for impact assessment

DEFF Research Database (Denmark)

Larsen, Sanne Vammen

2017-01-01

, the challenge of delivering assessments and predictions and the challenge of handling differences of opinion and debate. Through a case example of integration of climate change in strategic environmental assessment, the paper uses empirical evidence from a survey and a series of interviews to carry out......This paper takes its point of departure in Ulrich Beck’s theory of risk society and the aspects that characterise this society. The paper puts forward a hypothe- sis, on which theoretical challenges the characteristics of risk society pose to impact assessment as a decision support tool; namely...... a preliminary discussion of how the theoretical challenges are reflected in practice. The case study results show that the challenge of delivering assessments and predictions in a risk society is reflected in the current state of practice, while the challenge of handling differences of opinion and debate...

Nanotechnology and society

International Nuclear Information System (INIS)

Keller, Kenneth H.

2007-01-01

Past experience has shown that the successful introduction of a new technology requires careful attention to the interactions between the technology and society. These interactions are bi-directional: on the one hand, technology changes and challenges social patterns and, on the other hand, the governance structures and values of the society affect progress in developing the technology. Nanotechnology is likely to be particularly affected by these kinds of interactions because of its great promise and the unusually early public attention it has received. Moreover, it represents a new kind of experiment in packaging a rather wide range of fundamental research activities under a single 'mission-like' umbrella. Although this gives it more impetus as a field, it sets a higher bar for showing successful applications early on and because it links disparate fields, regulatory regimes reasonable for one kind of nanotechnology development may be inappropriately extended to others. There are a number of lessons to be gleaned from experience with the introduction of other technologies, which offer guidance with respect to what pitfalls to avoid and what issues to be sensitive to as we move forward with the development of nanotechnology applications. The problems encountered by nuclear power point out the dangers of over-promising and the role the need for the technology plays in ameliorating fears of risk. The public reaction to biomedical engineering and biotechnology highlights, in addition, the cultural factors that come into play when technologies raise questions about what is 'natural' and what is 'foreign' and what conceptions are involved in defining 'personhood'. In all cases, it has been clear that a main task for those introducing new technology is building public trust-in the safety of the technologies and the integrity of those introducing it. The advocates of nanotechnology have already shown that they are generally aware of the need to consider the public