Prostaglandin E2 activates the mTORC1 pathway through an EP4/cAMP/PKA- and EP1/Ca2+-mediated mechanism in the human pancreatic carcinoma cell line PANC-1.

Science.gov (United States)

Chang, Hui-Hua; Young, Steven H; Sinnett-Smith, James; Chou, Caroline Ei Ne; Moro, Aune; Hertzer, Kathleen M; Hines, Oscar Joe; Rozengurt, Enrique; Eibl, Guido

2015-11-15

Obesity, a known risk factor for pancreatic cancer, is associated with inflammation and insulin resistance. Proinflammatory prostaglandin E2 (PGE2) and elevated insulin-like growth factor type 1 (IGF-1), related to insulin resistance, are shown to play critical roles in pancreatic cancer progression. We aimed to explore a potential cross talk between PGE2 signaling and the IGF-1/Akt/mammalian target of rapamycin complex 1 (mTORC1) pathway in pancreatic cancer, which may be a key to unraveling the obesity-cancer link. In PANC-1 human pancreatic cancer cells, we showed that PGE2 stimulated mTORC1 activity independently of Akt, as evaluated by downstream signaling events. Subsequently, using pharmacological and genetic approaches, we demonstrated that PGE2-induced mTORC1 activation is mediated by the EP4/cAMP/PKA pathway, as well as an EP1/Ca(2+)-dependent pathway. The cooperative roles of the two pathways were supported by the maximal inhibition achieved with the combined pharmacological blockade, and the coexistence of highly expressed EP1 (mediating the Ca(2+) response) and EP2 or EP4 (mediating the cAMP/PKA pathway) in PANC-1 cells and in the prostate cancer line PC-3, which also robustly exhibited PGE2-induced mTORC1 activation, as identified from a screen in various cancer cell lines. Importantly, we showed a reinforcing interaction between PGE2 and IGF-1 on mTORC1 signaling, with an increase in IL-23 production as a cellular outcome. Our data reveal a previously unrecognized mechanism of PGE2-stimulated mTORC1 activation mediated by EP4/cAMP/PKA and EP1/Ca(2+) signaling, which may be of great importance in elucidating the promoting effects of obesity in pancreatic cancer. Ultimately, a precise understanding of these molecular links may provide novel targets for efficacious interventions devoid of adverse effects. Copyright © 2015 the American Physiological Society.

Small scale earthquake mechanisms induced by fluid injection at the enhanced geothermal system reservoir Soultz (Alsace) in 2003 using alternative source models

Czech Academy of Sciences Publication Activity Database

Šílený, Jan; Jechumtálová, Zuzana; Dorbath, C.

2014-01-01

Roč. 171, č. 10 (2014), s. 2783-2804 ISSN 0033-4553 R&D Projects: GA ČR GAP210/10/1728; GA ČR GAP210/12/2235 Institutional support: RVO:67985530 Keywords : non-shear component * Soultz-sous-Forets Alsace * HDR site * seismic events Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 1.618, year: 2014

Gravestones Speak--but in Which Language? Epitaphs as Mirrors of Language Shifts and Identities in Alsace

Science.gov (United States)

Vajta, Katharina

2018-01-01

This study examines how language choice in epitaphs in Alsatian cemeteries mirrors language shifts in Alsace, a region in Eastern France that changed nationalities between France and Germany four times between 1870 and 1945. Language choice on tombstones was expected to be made according to the language of the ruling power, but the results show…

Scientific results from the deepened Lopra-1 borehole, Faroe Islands: Thermal structure of the deep Lopra-1/1A borehole in the Faroe Islands

Directory of Open Access Journals (Sweden)

Breiner, Niels

2006-07-01

Full Text Available nformation on temperature, temperature gradients, thermal conductivity and heat flow from the c. 3.5 km deep Lopra-1/1A borehole in the Faroe Islands is presented and analysed. The upper 2450 m of the drilled sequence consists of thick tholeiitic basalt flows and the deeper parts of hyaloclastites and thin beds of basalt. Temperature data originate from high precision temperature logging a long time after drilling to a depth of 2175 m (the original Lopra-1 borehole and from commercial temperature logs measured a short time after drilling to a depth of 3430 m (Lopra-1/1A. The high-precision temperature log determines accurately levels of inflow of groundwater to the borehole and significantthermal disturbances to a depth of c. 1250 m. Below 1300 m, no significant disturbances are seen and interval temperature gradients for large depth intervals show only small variations between 28 and 33°C/km. The mean least-squares gradient for the depth interval of 1400–3430 m is 31.4°C/ km. In clear contrast to these overall very homogeneous, large-interval, mean temperature gradients, great local variability, between gradients of 20–25°C/km and 45°C/km, was observed between about 1300 and 2175 m (maximum depth of the high-resolution temperature log. These gradient variations are interpreted to be due to thermal conductivity variations and to reflect varying secondary mineralisation and mineral alterations.A preliminary analysis of the Lopra-1/1A temperature–depth function in terms of long-term palaeoclimatic signals indicates subsurface temperatures below about 1300 m to be in equilibrium with mean surface temperatures significantly below zero during the last glacial period. A subsequent temperature increase of 12–16°C occurred at around the termination of the last glaciation. The measured temperatures (some after correction and the thermal regime below 1300 m seem to represent conductive equilibrium conditions without significant disturbances

Voûtes d’ogives de l’époque romane en Alsace

Directory of Open Access Journals (Sweden)

Jean-Philippe Meyer

2012-05-01

Full Text Available La voûte d’ogives fut introduite dans les églises romanes de l’Alsace à partir de 1140-1150 environ (abbatiale de Murbach, collégiale de Lautenbach. Ce mode de voûtement s’imposa jusque dans de nombreux petits édifices à vaisseau unique. Dans les églises basilicales, les vaisseaux couverts de plafonds firent place, durant la seconde moitié du XIIe siècle, à des espaces rythmés d’abord de façon modérée, puis avec plus de vigueur. Vers 1200, les intérieurs furent dotés d’une puissante membrure ; faiblement éclairés, ils relèvent de recherches formelles qui se situent à l’opposé de celles poursuivies, au même moment, par les architectes d’Ile-de-France.Ribbed vaults appeared in the Romanesque churches of Alsace from about 1140-1150, notably at the abbey church of Murbach and the collegiate church of Lautenbach. This form of vaulting was subsequently found in many small buildings with single naves. In basilical churches, the naves covered with ceilings gave way, during the second half of the twelfth century, to spaces at first marked with discrete rythms, then with more vigour. Towards 1200, the interiors were characterised by strongly stated ribs. These dimly lit spaces suggest formal designs that were very different from the ones being developed at the same time by the architects of the Ile-de-France region.

Study of the renewable energy potential and development in Alsace

International Nuclear Information System (INIS)

2016-01-01

This report is part of a study which aimed at assessing the possibility of a renewable energy production equal to or greater than Alsace energy production between 2020 and 2050. It comprised an analysis of potentials and deadlocks for the development of each renewable energy. After an overview of renewable energy production by the end of 2012, the report addresses the different sectors (solar, biomass fuel, geothermal, heat recovery, aero-thermal, wind, hydroelectricity, methanization, agricultural fuels, transports). For each of them, it proposes assessments for the different specific technical resources and processes. Then, after a synthesis of the obtained maximum theoretical resources, it reports the development of three scenarios (a trend-based one, a maximum one, and a proactive one) while addressing each resource within them

Borehole sealing method and apparatus

International Nuclear Information System (INIS)

Hartley, J.N.; Jansen, G. Jr.

1977-01-01

A method and apparatus is described for sealing boreholes in the earth. The borehole is blocked at the sealing level, and a sealing apparatus capable of melting rock and earth is positioned in the borehole just above seal level. The apparatus is heated to rock-melting temperature and powdered rock or other sealing material is transported down the borehole to the apparatus where it is melted, pooling on the mechanical block and allowed to cool and solidify, sealing the hole. Any length of the borehole can be sealed by slowly raising the apparatus in the borehole while continuously supplying powdered rock to the apparatus to be melted and added to the top of the column of molten and cooling rock, forming a continuous borehole seal. The sealing apparatus consists of a heater capable of melting rock, including means for supplying power to the heater, means for transporting powdered rock down the borehole to the heater, means for cooling the apparatus and means for positioning the apparatus in the borehole. 5 claims, 1 figure

Delimitation of the Earliness per se D1 (Eps-D1) flowering gene to a subtelomeric chromosomal deletion in bread wheat (Triticum aestivum)

Science.gov (United States)

Zikhali, Meluleki; Wingen, Luzie U.; Griffiths, Simon

2016-01-01

Earliness per se (Eps) genes account for the variation in flowering time when vernalization and photoperiod requirements are satisfied. Genomics and bioinformatics approaches were used to describe allelic variation for 40 Triticum aestivum genes predicted, by synteny with Brachypodium distachyon, to be in the 1DL Eps region. Re-sequencing 1DL genes revealed that varieties carrying early heading alleles at this locus, Spark and Cadenza, carry a subtelomeric deletion including several genes. The equivalent region in Rialto and Avalon is intact. A bimodal distribution in the segregating Spark X Rialto single seed descent (SSD) populations enabled the 1DL QTL to be defined as a discrete Mendelian factor, which we named Eps-D1. Near isogenic lines (NILs) and NIL derived key recombinants between markers flanking Eps-D1 suggest that the 1DL deletion contains the gene(s) underlying Eps-D1. The deletion spans the equivalent of the Triticum monoccocum Eps-A m 1 locus, and hence includes MODIFIER OF TRANSCRIPTION 1 (MOT1) and FTSH PROTEASE 4 (FTSH4), the candidates for Eps-A m 1. The deletion also contains T. aestivum EARLY FLOWERING 3-D1 (TaELF3-D1) a homologue of the Arabidopsis thaliana circadian clock gene EARLY FLOWERING 3. Eps-D1 is possibly a homologue of Eps-B1 on chromosome 1BL. NILs carrying the Eps-D1 deletion have significantly reduced total TaELF3 expression and altered TaGIGANTEA (TaGI) expression compared with wild type. Altered TaGI expression is consistent with an ELF3 mutant, hence we propose TaELF3-D1 as the more likely candidate for Eps-D1. This is the first direct fine mapping of Eps effect in bread wheat. PMID:26476691

Delimitation of the Earliness per se D1 (Eps-D1) flowering gene to a subtelomeric chromosomal deletion in bread wheat (Triticum aestivum).

Science.gov (United States)

Zikhali, Meluleki; Wingen, Luzie U; Griffiths, Simon

2016-01-01

Earliness per se (Eps) genes account for the variation in flowering time when vernalization and photoperiod requirements are satisfied. Genomics and bioinformatics approaches were used to describe allelic variation for 40 Triticum aestivum genes predicted, by synteny with Brachypodium distachyon, to be in the 1DL Eps region. Re-sequencing 1DL genes revealed that varieties carrying early heading alleles at this locus, Spark and Cadenza, carry a subtelomeric deletion including several genes. The equivalent region in Rialto and Avalon is intact. A bimodal distribution in the segregating Spark X Rialto single seed descent (SSD) populations enabled the 1DL QTL to be defined as a discrete Mendelian factor, which we named Eps-D1. Near isogenic lines (NILs) and NIL derived key recombinants between markers flanking Eps-D1 suggest that the 1DL deletion contains the gene(s) underlying Eps-D1. The deletion spans the equivalent of the Triticum monoccocum Eps-A (m) 1 locus, and hence includes MODIFIER OF TRANSCRIPTION 1 (MOT1) and FTSH PROTEASE 4 (FTSH4), the candidates for Eps-A (m) 1. The deletion also contains T. aestivum EARLY FLOWERING 3-D1 (TaELF3-D1) a homologue of the Arabidopsis thaliana circadian clock gene EARLY FLOWERING 3. Eps-D1 is possibly a homologue of Eps-B1 on chromosome 1BL. NILs carrying the Eps-D1 deletion have significantly reduced total TaELF3 expression and altered TaGIGANTEA (TaGI) expression compared with wild type. Altered TaGI expression is consistent with an ELF3 mutant, hence we propose TaELF3-D1 as the more likely candidate for Eps-D1. This is the first direct fine mapping of Eps effect in bread wheat. © The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology.

Borehole induction coil transmitter

Science.gov (United States)

Holladay, Gale; Wilt, Michael J.

2002-01-01

A borehole induction coil transmitter which is a part of a cross-borehole electromagnetic field system that is used for underground imaging applications. The transmitter consists of four major parts: 1) a wound ferrite or mu-metal core, 2) an array of tuning capacitors, 3) a current driver circuit board, and 4) a flux monitor. The core is wound with several hundred turns of wire and connected in series with the capacitor array, to produce a tuned coil. This tuned coil uses internal circuitry to generate sinusoidal signals that are transmitted through the earth to a receiver coil in another borehole. The transmitter can operate at frequencies from 1-200 kHz and supplies sufficient power to permit the field system to operate in boreholes separated by up to 400 meters.

Results of hydraulic tests at Gibson Dome No. 1, Elk Ridge No. 1, and E. J. Kubat boreholes, Paradox Basin, Utah

International Nuclear Information System (INIS)

Thackston, J.W.; Preslo, L.M.; Hoexter, D.E.; Donnelly, N.

1984-03-01

Hydraulic testing was conducted in three boreholes in southeastern Utah to provide a portion of the data needed to characterize the hydrogeology of the Elk Ridge and Gibson Dome areas of the western Paradox Basin, Utah. The tests at the E. J. Kubat borehole yielded representative values of transmissivity, hydraulic conductivity, storativity, and potentiometric levels of the Leadville Limestone. Testing at Elk Ridge No. 1 provided values of similar parameters for the combined thickness of the upper Honaker Trail, Elephant Canyon, and Cedar Mesa formations. Composite transmissivities of similar zones from these borehole tests compared closely with the results of testing at borehole GD-1. A comparison of results from lab tests on core with results of extensive borehole testing at GD-1 indicates that short-term drill stem tests in a single well can provide representative estimates of bulk transmissivities and hydraulic conductivities in this field area for test zones that have a hydraulic conductivity of greater than about 1 x 10 -7 cm/sec. However, lab tests produce more representative values of effective porosity and matrix permeability of individual strata. Results of lab tests and long-term borehole tests confirm that the lower Honaker Trail and upper Paradox formations have extremely low conductivities in the vicinity of the GD-1 borehole. The results of these tests were complete as of January 1981. 22 references, 29 figures, 5 tables

Excavation damage and organic growth in a 1.2m diameter borehole

International Nuclear Information System (INIS)

Everitt, R.A.; Gann, P.; Brown, D.A.; Boychuk, D.M.

1994-01-01

A 1.24m diameter borehole was drilled 5m into the floor of a typical drill-and-blast tunnel in unfractured granite, at AECL's Underground Research Laboratory. Three generations of excavation damage, characteristic of what may be encountered in boreholes excavated for in-hole emplacement of used fuel wastes was observed. These include: (1) damage related to the initial excavation of the room, (2) damage caused by the drilling of the borehole itself, and (3) damage due to subsequent stress-induced spalling of the borehole walls. A biofilm containing a variety of microorganisms has developed where seepage issues from the concrete-granite interface. The biota were introduced from surface water used for mining and drilling. Their growth has been stimulated by residues from blasting and drilling, which have concentrated iron and silicon by passive sorption and energy metabolism. Ferrous iron has been oxidized and precipitated as ferrihydrite/hematite to give an orange/brown colouration on the biofilm interface black. These observations, significant to the understanding and monitoring of excavation damage, highlight the importance of thorough, in situ, multi-disciplinary characterization for vault design

200-ZP-1 operable unit borehole summary report for FY 1995 and FY 1996

International Nuclear Information System (INIS)

Darrach, M.E.

1996-10-01

This document details the well construction, sampling, analyses, and geologic character of the Ringold Formation fluvial unit E gravels as encountered in 16 boreholes in the 200-ZP-1 Operable Unit. These boreholes were drilled by Water Development Hanford Corporation during fiscal years 1995 and 1996. Two of the sixteen boreholes were abandoned; the remaining 14 boreholes were completed as functioning production and compliance wells. The borehole logs and well summary sheets included as Appendices A and B of this document, respectively, depict and describe the vadose zone stratigraphic units encountered during the course of drilling. Appendix C contains the results of sieve analyses conducted on samples obtained via resonant sonic coring and standard split-spoon methods. The sieve analyses were the driver behind the majority of the well designs. Also, for completeness, Appendices D and E contain the well design calculations and the well development process

Designing a low-cost effective network for monitoring large scale regional seismicity in a soft-soil region (Alsace, France)

Science.gov (United States)

Bès de Berc, M.; Doubre, C.; Wodling, H.; Jund, H.; Hernandez, A.; Blumentritt, H.

2015-12-01

The Seismological Observatory of the North-East of France (ObSNEF) is developing its monitoring network within the framework of several projects. Among these project, RESIF (Réseau sismologique et géodésique français) allows the instrumentation of broad-band seismic stations, separated by 50-100 km. With the recent and future development of geothermal industrial projects in the Alsace region, the ObSNEF is responsible for designing, building and operating a dense regional seismic network in order to detect and localize earthquakes with both a completeness magnitude of 1.5 and no clipping for M6.0. The realization of the project has to be done prior to the summer 2016Several complex technical and financial constraints constitute such a projet. First, most of the Alsace Région (150x150 km2), particularly the whole Upper Rhine Graben, is a soft-soil plain where seismic signals are dominated by a high frequency noise level. Second, all the signals have to be transmitted in near real-time. And finally, the total cost of the project must not exceed $450,000.Regarding the noise level in Alsace, in order to make a reduction of 40 dB for frequencies above 1Hz, we program to instrument into 50m deep well with post-hole sensor for 5 stations out of 8 plane new stations. The 3 remaining would be located on bedrock along the Vosges piedmont. In order to be sensitive to low-magnitude regional events, we plan to install a low-noise short-period post-hole velocimeter. In order to avoid saturation for high potentiel local events (M6.0 at 10km), this velocimeter will be coupled with a surface strong-motion sensor. Regarding the connectivity, these stations will have no wired network, which reduces linking costs and delays. We will therefore use solar panels and a 3G/GPRS network. The infrastructure will be minimal and reduced to an outdoor box on a secured parcel of land. In addition to the data-logger, we will use a 12V ruggedized computer, hosting a seed-link server for near

The Eps15 C. elegans homologue EHS-1 is implicated in synaptic vesicle recycling

DEFF Research Database (Denmark)

Salcini, A E; Hilliard, M A; Croce, A

2001-01-01

implicated Eps15 in endocytosis, its function in the endocytic machinery remains unclear. Here we show that the Caenorhabditis elegans gene, zk1248.3 (ehs-1), is the orthologue of Eps15 in nematodes, and that its product, EHS-1, localizes to synaptic-rich regions. ehs-1-impaired worms showed temperature...

A novel biosorbent for dye removal: Extracellular polymeric substance (EPS) of Proteus mirabilis TJ-1

Energy Technology Data Exchange (ETDEWEB)

Zhang Zhiqiang [State Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze River Water Environment of Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092 (China); Laboratoire de Sciences Analytiques (UMR CNRS 5180), Universite Claude Bernard Lyon 1, Universite de Lyon, 69622 Villeurbanne Cedex (France); Xia Siqing [State Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze River Water Environment of Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092 (China)], E-mail: siqingxia@mail.tongji.edu.cn; Wang Xuejiang; Yang Aming; Xu Bin; Chen Ling; Zhu Zhiliang; Zhao Jianfu [State Key Laboratory of Pollution Control and Resource Reuse, Key Laboratory of Yangtze River Water Environment of Ministry of Education, College of Environmental Science and Engineering, Tongji University, Shanghai 200092 (China); Jaffrezic-Renault, Nicole; Leonard, Didier [Laboratoire de Sciences Analytiques (UMR CNRS 5180), Universite Claude Bernard Lyon 1, Universite de Lyon, 69622 Villeurbanne Cedex (France)

2009-04-15

This paper deals with the extracellular polymeric substance (EPS) of Proteus mirabilis TJ-1 used as a novel biosorbent to remove dye from aqueous solution in batch systems. As a widely used and hazardous dye, basic blue 54 (BB54) was chosen as the model dye to examine the adsorption performance of the EPS. The effects of pH, initial dye concentration, contact time and temperature on the sorption of BB54 to the EPS were examined. At various initial dye concentrations (50-400 mg/L), the batch sorption equilibrium can be obtained in only 5 min. Kinetic studies suggested that the sorption followed the internal transport mechanism. According to the Langmuir model, the maximum BB54 uptake of 2.005 g/g was obtained. Chemical analysis of the EPS indicated the presence of protein (30.9%, w/w) and acid polysaccharide (63.1%, w/w). Scanning electron microscopy (SEM) images showed that the EPS with a crystal-linear structure was whole enwrapped by adsorbed dye molecules. FTIR spectrum result revealed the presence of adsorbing groups such as carboxyl, hydroxyl and amino groups in the EPS. High-molecular weight of the EPS with more binding-sites and stronger van der Waals forces together with its specific construct leads to the excellent performance of dye adsorption. The EPS shows potential board application as a biosorbent for both environmental protection and dye recovery.

A novel biosorbent for dye removal: Extracellular polymeric substance (EPS) of Proteus mirabilis TJ-1

International Nuclear Information System (INIS)

Zhang Zhiqiang; Xia Siqing; Wang Xuejiang; Yang Aming; Xu Bin; Chen Ling; Zhu Zhiliang; Zhao Jianfu; Jaffrezic-Renault, Nicole; Leonard, Didier

2009-01-01

This paper deals with the extracellular polymeric substance (EPS) of Proteus mirabilis TJ-1 used as a novel biosorbent to remove dye from aqueous solution in batch systems. As a widely used and hazardous dye, basic blue 54 (BB54) was chosen as the model dye to examine the adsorption performance of the EPS. The effects of pH, initial dye concentration, contact time and temperature on the sorption of BB54 to the EPS were examined. At various initial dye concentrations (50-400 mg/L), the batch sorption equilibrium can be obtained in only 5 min. Kinetic studies suggested that the sorption followed the internal transport mechanism. According to the Langmuir model, the maximum BB54 uptake of 2.005 g/g was obtained. Chemical analysis of the EPS indicated the presence of protein (30.9%, w/w) and acid polysaccharide (63.1%, w/w). Scanning electron microscopy (SEM) images showed that the EPS with a crystal-linear structure was whole enwrapped by adsorbed dye molecules. FTIR spectrum result revealed the presence of adsorbing groups such as carboxyl, hydroxyl and amino groups in the EPS. High-molecular weight of the EPS with more binding-sites and stronger van der Waals forces together with its specific construct leads to the excellent performance of dye adsorption. The EPS shows potential board application as a biosorbent for both environmental protection and dye recovery

Deep Borehole Field Test Laboratory and Borehole Testing Strategy

Energy Technology Data Exchange (ETDEWEB)

Kuhlman, Kristopher L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brady, Patrick V. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); MacKinnon, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Heath, Jason E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Herrick, Courtney G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jensen, Richard P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Gardner, W. Payton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bryan, Charles R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jang, Je-Hun [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stein, Emily R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bauer, Stephen J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Daley, Tom [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Freifeld, Barry M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Birkholzer, Jens [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Spane, Frank A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-09-19

Deep Borehole Disposal (DBD) of high-level radioactive wastes has been considered an option for geological isolation for many years (Hess et al. 1957). Recent advances in drilling technology have decreased costs and increased reliability for large-diameter (i.e., ≥50 cm [19.7”]) boreholes to depths of several kilometers (Beswick 2008; Beswick et al. 2014). These advances have therefore also increased the feasibility of the DBD concept (Brady et al. 2009; Cornwall 2015), and the current field test design will demonstrate the DBD concept and these advances. The US Department of Energy (DOE) Strategy for the Management and Disposal of Used Nuclear Fuel and High-Level Radioactive Waste (DOE 2013) specifically recommended developing a research and development plan for DBD. DOE sought input or expression of interest from States, local communities, individuals, private groups, academia, or any other stakeholders willing to host a Deep Borehole Field Test (DBFT). The DBFT includes drilling two boreholes nominally 200m [656’] apart to approximately 5 km [16,400’] total depth, in a region where crystalline basement is expected to begin at less than 2 km depth [6,560’]. The characterization borehole (CB) is the smaller-diameter borehole (i.e., 21.6 cm [8.5”] diameter at total depth), and will be drilled first. The geologic, hydrogeologic, geochemical, geomechanical and thermal testing will take place in the CB. The field test borehole (FTB) is the larger-diameter borehole (i.e., 43.2 cm [17”] diameter at total depth). Surface handling and borehole emplacement of test package will be demonstrated using the FTB to evaluate engineering feasibility and safety of disposal operations (SNL 2016).

Prostaglandin E2 EP2 and EP4 receptor activation mediates cAMP-dependent hyperpolarization and exocytosis of renin in juxtaglomerular cells

DEFF Research Database (Denmark)

Friis, Ulla Glenert; Stubbe, Jane; Uhrenholt, Torben Rene

2005-01-01

/l), AE1-259-01 (1 nmol/l), EP4-selective agonist AE1-329 (1 nmol/l), and IP agonist iloprost (1 micromol/l) significantly increased C(m) mediated by PKA. The EP4 antagonist AE3-208 (10 nmol/l) blocked the effect of EP4 agonist but did not alter the response to PGE(2). Application of both EP4 antagonist....... The membrane potential hyperpolarized significantly after PGE(2), butaprost, AE1-329 and AE1-259 and outward current was augmented in a PKA-dependent fashion. PGE(2)-stimulated outward current, but not C(m) change, was abolished by the BK(Ca) channel inhibitor iberiotoxin (300 nmol/l). EP2 and EP4 m......RNA was detected in sampled JG cells, and the preglomerular and glomerular vasculature was immunopositive for EP4. Thus IP, EP2, and EP4 receptors are associated with JG cells, and their activation leads to rapid PKA-mediated exocytotic fusion and release of renin granules....

EP BICYCLE POOL - VIGNETTES 2002

CERN Multimedia

EP-SMI Help Desk

2002-01-01

The vignettes (insurance certificates) for 2002 become obligatory from 1 June. If you have a bicycle from the EP Pool, please bring it to the EP-SMI Help Desk (Building 124) on any working day up to 31 May between 8h.30 - 12h.00 or 13h.30 - 17h.30. EP-SMI Help Desk

Oman Drilling Project Phase I Borehole Geophysical Survey

Science.gov (United States)

Matter, J. M.; Pezard, P. A.; Henry, G.; Brun, L.; Célérier, B.; Lods, G.; Robert, P.; Benchikh, A. M.; Al Shukaili, M.; Al Qassabi, A.

2017-12-01

The Oman Drilling Project (OmanDP) drilled six holes at six sites in the Samail ophiolite in the southern Samail and Tayin massifs. 1500-m of igneous and metamorphic rocks were recovered at four sites (GT1, GT2, GT3 and BT1) using wireline diamond core drilling and drill cuttings at two sites (BA1, BA2) using air rotary drilling, respectively. OmanDP is an international collaboration supported by the International Continental Scientific Drilling Program, the Deep Carbon Observatory, NSF, NASA, IODP, JAMSTEC, and the European, Japanese, German and Swiss Science Foundations, and with in-kind support in Oman from Ministry of Regional Municipalities and Water Resources, Public Authority of Mining, Sultan Qaboos University and the German University of Technology. A comprehensive borehole geophysical survey was conducted in all the OmanDP Phase I boreholes shortly after drilling in April 2017. Following geophysical wireline logs, using slim-hole borehole logging equipment provided and run by the Centre National De La Recherche Scientifique (CNRS) and the Université de Montpellier/ Géosciences Montpellier, and logging trucks from the Ministry of Regional Municipalities and Water Resources, were collected in most of the holes: electrical resistivity (dual laterolog resistivity, LLd and LLs), spectral gamma ray (K, U, and Th contents), magnetic susceptibility, total natural gamma ray, full waveform sonic (Vp and Vs), acoustic borehole wall imaging, optical borehole wall imaging, borehole fluid parameters (pressure, temperature, electrical conductivity, dissolved oxygen, pH, redox potential, non-polarized spontaneous electrical potential), and caliper (borehole diameter). In addition, spinner flowmeter (downhole fluid flow rate along borehole axis) and heatpulse flow meter logs (dowhole fluid flow rate along borehole axis) were collected in BA1 to characterize downhole fluid flow rates along borehole axis. Unfortuantely, only incomplete wireline logs are available for

An overview of the MIZ-1 borehole investigations during phase I/II. MIZ-1 progress report 03-01

International Nuclear Information System (INIS)

Ota, Kunio; Takeuchi, Shinji; Ikeda, Koki

2004-05-01

Surface-based investigations have now been carried out, in a step-by-step fashion, with the main aims of the development of conceptual models of the geological environment and the enhancement of the understanding of the undisturbed deep geological environment before excavation of the shafts and experimental drifts. The MIZ-1 borehole investigation programme was launched in December 2002, as a step of the field investigations at the MIU Construction Site. The overall goals of the MIZ-1 borehole investigations are to characterise the geological environment from the surface to over 1,000 m depth in the crystalline basement, to establish baseline conditions before excavation of the shafts and experimental drifts, and to provide a deep borehole for observing hydraulic responses during the shaft and drift excavation and experiments in the drifts during the Construction and the Operation Phases. The borehole is planned to be drilled in an overall south-westerly direction from the north-eastern area of the MIU Site. The planned inclination varies from vertical at shallower depths to 12deg from vertical at greater depths down to 1,350 m along the borehole length, which will be achieved by controlled directional drilling. In MIZ-1 Phase I/II (from March to May 2003), the borehole was drilled vertically, through the entire sedimentary formations, down to 123.00 m in the uppermost part of the Toki granite at the MIU Construction Site. The new method of wireline core drilling with a downhole motor was introduced for the drilling. Planned geological, geophysical and hydrochemical investigations and complementary hydraulic and hydrochemical monitoring were performed. In addition, as a complete loss of drilling fluid was encountered at 115.85 m along the borehole length, modified work procedures resulted in the execution of hydraulic tests with groundwater sampling, from necessity, in that section and of further drilling work. The local QC system was applied to all the

Effects of the deviation characteristics of nuclear waste emplacement boreholes on borehole liner stresses

International Nuclear Information System (INIS)

Glowka, D.A.

1990-09-01

This report investigates the effects of borehole deviation on the useability of lined boreholes for the disposal of high-level nuclear waste at the proposed Yucca Mountain Repository in Nevada. Items that lead to constraints on borehole deviation include excessive stresses that could cause liner failure and possible binding of a waste container inside the liner during waste emplacement and retrieval operations. Liner stress models are developed for two general borehole configurations, one for boreholes drilled with a steerable bit and one for boreholes drilled with a non-steerable bit. Procedures are developed for calculating liner stresses that arise both during insertion of the liner into a borehole and during the thermal expansion process that follows waste emplacement. The effects of borehole curvature on the ability of the waste container to pass freely inside the liner without binding are also examined. Based on the results, specifications on borehole deviation allowances are developed for specific vertical and horizontal borehole configurations of current interest. 11 refs., 22 figs., 4 tabs

Obligatory Role of EP1 Receptors in the Increase in Cerebral Blood Flow Produced by Hypercapnia in the Mice.

Directory of Open Access Journals (Sweden)

Ken Uekawa

Full Text Available Hypercapnia induces potent vasodilation in the cerebral circulation. Although it has long been known that prostanoids participate in the cerebrovascular effects of hypercapnia, the role of prostaglandin E2 (PGE2 and PGE2 receptors have not been fully investigated. In this study, we sought to determine whether cyclooxygenase-1 (COX-1-derived PGE2 and EP1 receptors are involved in the cerebrovascular response induced by hypercapnia. Cerebral blood flow (CBF was recorded by laser-Doppler flowmetry in the somatosenasory cortex of anesthetized male EP1-/- mice and wild type (WT littermates. In WT mice, neocortical application of the EP1 receptor antagonist SC-51089 attenuated the increase in CBF elicited by systemic hypercapnia (pCO2 = 50-60 mmHg. SC-51089 also attenuated the increase in CBF produced by neocortical treatment of arachidonic acid or PGE2. These CBF responses were also attenuated in EP1-/- mice. In WT mice, the COX-1 inhibitor SC-560, but not the COX-2 inhibitor NS-398, attenuated the hypercapnic CBF increase. Neocortical application of exogenous PGE2 restored the attenuation in resting CBF and the hypercapnic response induced by SC-560. In contrast, exogenous PGE2 failed to rescue the attenuation both in WT mice induced by SC-51089 and EP1-/- mice, attesting to the obligatory role of EP1 receptors in the response. These findings indicate that the hypercapnic vasodilatation depends on COX-1-derived PGE2 acting on EP1 receptors and highlight the critical role that COX-1-derived PGE2 and EP1 receptors play in the hypercapnic regulation of the cerebral circulation.

The prostaglandin EP1 receptor potentiates kainate receptor activation via a protein kinase C pathway and exacerbates status epilepticus

Science.gov (United States)

Rojas, Asheebo; Gueorguieva, Paoula; Lelutiu, Nadia; Quan, Yi; Shaw, Renee; Dingledine, Raymond

2014-01-01

Prostaglandin E2 (PGE2) regulates membrane excitability, synaptic transmission, plasticity, and neuronal survival. The consequences of PGE2 release following seizures has been the subject of much study. Here we demonstrate that the prostaglandin E2 receptor 1 (EP1, or Ptger1) modulates native kainate receptors, a family of ionotropic glutamate receptors widely expressed throughout the central nervous system. Global ablation of the EP1 gene in mice (EP1-KO) had no effect on seizure threshold after kainate injection but reduced the likelihood to enter status epilepticus. EP1-KO mice that did experience typical status epilepticus had reduced hippocampal neurodegeneration and a blunted inflammatory response. Further studies with native prostanoid and kainate receptors in cultured cortical neurons, as well as with recombinant prostanoid and kainate receptors expressed in Xenopus oocytes, demonstrated that EP1 receptor activation potentiates heteromeric but not homomeric kainate receptors via a second messenger cascade involving phospholipase C, calcium and protein kinase C. Three critical GluK5 C-terminal serines underlie the potentiation of the GluK2/GluK5 receptor by EP1 activation. Taken together, these results indicate that EP1 receptor activation during seizures, through a protein kinase C pathway, increases the probability of kainic acid induced status epilepticus, and independently promotes hippocampal neurodegeneration and a broad inflammatory response. PMID:24952362

Borehole logging

International Nuclear Information System (INIS)

Olsen, H.

1995-01-01

Numerous ground water investigations have been accomplished by means of borehole logging. Borehole logging can be applied to establish new water recovery wells, to control the existing water producing wells and source areas and to estimate ground water quality. (EG)

Borehole disposal of spent radiation sources: 1. Principles

International Nuclear Information System (INIS)

Blerk, J.J. van; Kozak, M.W.

2000-01-01

Large numbers of spent radiation sources from the medical and other technical professions exist in many countries, even countries that do not possess facilities related to the nuclear fuel cycle, that have to be disposed. This is particularly the case in Africa, South America and some members of the Russian Federation. Since these sources need to be handled separately from the other types of radioactive waste, mainly because of their activity to volume ratio, countries (even those with access to operational repositories) find it difficult to manage and dispose this waste. This has led to the use of boreholes as disposal units for these spent sources by some members of the Russian Federation and in South Africa. However, the relatively shallow boreholes used by these countries are not suitable for the disposal of isotopes with long half-lifes, such as 226 Ra and 241 Am. With this in mind the Atomic Energy Corporation of South Africa initiated the development of the BOSS disposal concept - an acronym for Borehole disposal Of Spent Sources - as part of an International Atomic Energy Agency (IAEA) AFRA I-14 Technical Corporation (TC) project. In this paper, the principles of this disposal concept, which is still under development, will be discussed. (author)

Geophysical logs and water-quality data collected for boreholes Kimama-1A and -1B, and a Kimama water supply well near Kimama, southern Idaho

Science.gov (United States)

Twining, Brian V.; Bartholomay, Roy C.

2011-01-01

In September 2010, a research consortium led by scientists from Utah State University began drilling the first of three continuously cored boreholes on the Snake River Plain in southern Idaho. The goals of this effort, the Snake River Scientific Drilling Project, are to study the interaction between the Earth's crust and mantle, to identify potential geothermal energy sources, and to track the evolution of the Yellowstone hotspot on the Snake River Plain. The first borehole, located near Kimama, Idaho, is about 50 miles southwest of the U.S. Department of Energy's Idaho National Laboratory. Because geohydrologic data are scarce for that area of the central Snake River Plain, the Kimama borehole, completed in January 2011, provided a unique opportunity to collect geophysical and water-chemistry data from the eastern Snake River Plain aquifer system, downgradient of the laboratory. Therefore, in conjunction with the Snake River Scientific Drilling Project, scientists from the U.S. Geological Survey's Idaho National Laboratory Project Office conducted geophysical logging and collected water samples at the Kimama site. Wireline geophysical logs were collected for the diverging borehole, Kimama-1A and -1B, from land surface to 976 and 2,498 feet below land surface (BLS), respectively. Water samples were collected from Kimama-1A at depths near 460 and 830 feet BLS, and from the Kimama Water Supply (KWS) well located about 75 feet away. Geophysical log data included a composite of natural gamma, neutron, gamma-gamma dual density, and gyroscopic analysis for boreholes Kimama-1A and -1B. Geophysical logs depicted eight sediment layers (excluding surficial sediment) ranging from 4 to 60 feet in thickness. About 155 individual basalt flows were identified, ranging from less than 3 feet to more than 175 feet in thickness (averaging 15 feet) for borehole Kimama-1B (0 to 2,498 feet BLS). Sediment and basalt contacts were selected based on geophysical traces and were confirmed

Brief Report: Medication Sharing Is Rare Among African HIV-1 Serodiscordant Couples Enrolled in an Efficacy Trial of Oral Pre-exposure Prophylaxis (PrEP) for HIV-1 Prevention.

Science.gov (United States)

Thomson, Kerry A; Haberer, Jessica E; Marzinke, Mark A; Mujugira, Andrew; Hendrix, Craig W; Celum, Connie; Ndase, Patrick; Ronald, Allan; Bangsberg, David R; Baeten, Jared M

2017-06-01

Sharing of pre-exposure prophylaxis (PrEP) medications is a concern for PrEP implementation. For HIV-1 serodiscordant couples, sharing may undermine the HIV-1 prevention benefit and also cause antiretroviral resistance if taken by HIV-1 infected partners. Within a PrEP efficacy trial among HIV-1 serodiscordant couples, we assessed the occurrence of PrEP sharing by self-report and plasma tenofovir concentrations in HIV-1 infected partners. PrEP sharing was self-reported at <0.01% of visits, and 0%-1.6% of randomly selected and 0% of purposively selected specimens from HIV-1 infected participants had detectable tenofovir concentrations (median: 66.5 ng/mL, range: 1.3-292 ng/mL). PrEP sharing within HIV-1 serodiscordant couples was extremely rare.

Borehole radar and BIPS investigations in boreholes at the Boda area

Energy Technology Data Exchange (ETDEWEB)

Carlsten, S.; Straahle, A. [GEOSIGMA AB, Uppsala (Sweden)

2000-12-01

As part of the studies conducted in the Boda area, measurements with borehole radar, borehole TV (BIPS) and deviation measurements were performed during May 2000. The investigations were carried out in four percussion-drilled boreholes with a total length of 514 m. Two boreholes are vertical and two are directed into and below the cave area. The BIPS measurement showed the presence of 14 open fractures. Largest apparent aperture width of open fractures was 133 mm. In the lowest part in boreholes 2, 3, and 4, particles in suspension deteriorated the visibility. BIPS has revealed a dominating subhorizontal fracture set and another striking NW to N-S with a dip close to vertical. Possible but very uncertain is a third fracture set striking NE and dipping steeply towards S. The open and partly open fractures forms an average block size 11 m wide and 6 m high, while the length of the block is uncertain. Of 98 borehole radar reflectors interpreted to intersect within BIPS-mapped sections, 90 were possible to combine with BIPS-mapped structures, i.e. 92% of the radar reflectors. The fractured rock around Boda is a shallow feature, since borehole radar and BIPS measurements shows no evidence of increased fracturing or the presence of caves at larger depth in the Boda area. The result indicates that the formation of the superficial fracture system (with caves included) at Boda in all probability is connected to glacial action, such as banking.

Borehole radar and BIPS investigations in boreholes at the Boda area

International Nuclear Information System (INIS)

Carlsten, S.; Straahle, A.

2000-12-01

As part of the studies conducted in the Boda area, measurements with borehole radar, borehole TV (BIPS) and deviation measurements were performed during May 2000. The investigations were carried out in four percussion-drilled boreholes with a total length of 514 m. Two boreholes are vertical and two are directed into and below the cave area. The BIPS measurement showed the presence of 14 open fractures. Largest apparent aperture width of open fractures was 133 mm. In the lowest part in boreholes 2, 3, and 4, particles in suspension deteriorated the visibility. BIPS has revealed a dominating subhorizontal fracture set and another striking NW to N-S with a dip close to vertical. Possible but very uncertain is a third fracture set striking NE and dipping steeply towards S. The open and partly open fractures forms an average block size 11 m wide and 6 m high, while the length of the block is uncertain. Of 98 borehole radar reflectors interpreted to intersect within BIPS-mapped sections, 90 were possible to combine with BIPS-mapped structures, i.e. 92% of the radar reflectors. The fractured rock around Boda is a shallow feature, since borehole radar and BIPS measurements shows no evidence of increased fracturing or the presence of caves at larger depth in the Boda area. The result indicates that the formation of the superficial fracture system (with caves included) at Boda in all probability is connected to glacial action, such as banking

A maladaptive role for EP4 receptors in mouse mesangial cells.

Directory of Open Access Journals (Sweden)

Guang-xia Yang

Full Text Available Roles of the prostaglandin E2 E-prostanoid 4 receptor (EP4 on extracellular matrix (ECM accumulation induced by TGF-β1 in mouse glomerular mesangial cells (GMCs remain unknown. Previously, we have identified that TGF-β1 stimulates the expression of FN and Col I in mouse GMCs. Here we asked whether stimulation of EP4 receptors would exacerbate renal fibrosis associated with enhanced glomerular ECM accumulation. We generated EP4(Flox/Flox and EP4(+/- mice, cultured primary WT, EP4(Flox/Flox and EP4(+/- GMCs, AD-EP4 transfected WT GMCs (EP4 overexpression and AD-Cre transfected EP4(Flox/Flox GMCs (EP4 deleted. We found that TGF-β1-induced cAMP and PGE2 synthesis decreased in EP4 deleted GMCs and increased in EP4 overexpressed GMCs. Elevated EP4 expression in GMCs augmented the coupling of TGF-β1 to FN, Col I expression and COX2/PGE2 signaling, while TGF-β1 induced FN, Col I expression and COX2/PGE2 signaling were down-regulated in EP4 deficiency GMCs. 8 weeks after 5/6 nephrectomy (Nx, WT and EP4(+/- mice exhibited markedly increased accumulation of ECM compared with sham-operated controls. Albuminuria, blood urea nitrogen and creatinine (BUN and Cr concentrations were significantly increased in WT mice as compared to those of EP4(+/- mice. Urine osmotic pressure was dramatically decreased after 5/6 Nx surgery in WT mice as compared to EP4(+/- mice. The pathological changes in kidney of EP4(+/- mice was markedly alleviated compared with WT mice. Immunohistochemical analysis showed significant reductions of Col I and FN in the kidney of EP4(+/- mice compared with WT mice. Collectively, this investigation established EP4 as a potent mediator of the pro-TGF-β1 activities elicited by COX2/PGE2 in mice GMCs. Our findings suggested that prostaglandin E2, acting via EP4 receptors contributed to accumulation of ECM in GMCs and promoted renal fibrosis.

Nature of the endogenous pyrogen (EP) induced by influenza viruses: lack of correlation between EP levels and content of the known pyrogenic cytokines, interleukin 1, interleukin 6 and tumour necrosis factor.

Science.gov (United States)

Jakeman, K J; Bird, C R; Thorpe, R; Smith, H; Sweet, C

1991-03-01

Fever in influenza results from the release of endogenous pyrogen (EP) following virus-phagocyte interaction and its level correlates with the differing virulence of virus strains. However, the different levels of fever produced in ferrets by intracardial inoculation of EP obtained from the interaction of different virus strains with ferret of human phagocytes did not correlate with the levels of interleukin 1 (IL-1), IL-6 or tumour necrosis factor in the same samples as assayed by conventional in vitro methods. Hence, the EP produced by influenza virus appears to be different to these cytokines.

Site study plan for EDBH [Engineering Design Boreholes] No. 1 and 2: Revision 1

International Nuclear Information System (INIS)

1987-12-01

This site study plan describes the Engineering Design Boreholes 1 and 2 field activities to be conducted during early stages of Site Characterization at the Deaf Smith County site, Texas. The field program has been designed to provide data useful in addressing information/data needs resulting from federal/state/local regulations and repository program requirements. A borehole will be drilled at the centerline of each of the planned exploratory shaft locations. The subsurface rock and fluids will be sampled as the boreholes are advanced to total depth of about 2600 ft. Continuous rock core will be taken below the base of the Dockum Group. Hydrologic testing will occur in units thought to be water bearing and in units of particular interest for shaft seals. Field methods/tests are chosen that provide the best or only means of obtaining the required data. The Salt Repository Project (SRP) Networks specify the schedule under which the program will operate. Drilling will not begin until after site ground-water baseline conditions have been established. The Technical Field Services Contractor is responsible for conducting the field program of drilling and testing. Samples and data will be handled and reported in accordance with established SRP procedures. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that the appropriate documentation is maintained. 28 refs., 10 figs., 4 tabs

Site characterization and validation - drift and borehole fracture data. Stage 1

International Nuclear Information System (INIS)

Gale, J.; Straahle, A.

1988-09-01

This report describes the procedures used in mapping fractures intersecting seven scanlines along the southern and eastern boundaries of the Site Characterization and Validation (SCV) site and the procedures used in logging and orienting the fractures intersecting the core from six 'boundary boreholes' that were drilled as part of the site characterization program for the SCV site at the 360 m level in the Stripa mine. Scanline mapping along the mine drifts provided a detailed description of the fracture geomentry on the boundaries of the SCV site. The cores from the boundary boreholes have been logged, reconstructed and oriented using a borehole Televiewer and a borehole TV camera and the true fracture orientations calcilated. This has provide additional data on the fracture geometry within the SCV site. The fractire data from both the scanlines and the core logging are presented in the appendices. In addition, an initial analysis has been completed of the fracture orientations, trace lengths and spacings. Based on the variation in fracture orientations over the SCV site, there are two strong subvertical fracture sets or or clusters and a poorly represented sub-horizontal fracture set. An empirical approach, based on the 'blind zone' concept has been used to correct for orientation bias and to predict the orientations of the fracture system that will be intersected by the C and D boreholes in stage III. (33 figs., 6 tabl., 19 refs.)

Fission-track dating of apatite from deep borehole ATK-1 at Atikokan, Ontario

International Nuclear Information System (INIS)

Naeser, C.W.; Crowley, K.D.

1990-01-01

Fission-track age and lengths have been determined on apatite separated from core recovered from the ATK-1 deep borehole at Atikokan, Ontario. The apatite ages decrease down the borehole, from 515 ± 72 Ma at the top to 376 ± 46 Ma at a depth of 993 m. The mean confined track length for fossil fission tracks in the apatite is 12.4 μm. Within the limits of the measurement the track lengths are the same for all the samples. The results of this study indicate that the rocks found currently at the surface have never been heated above ∼100C since Upper Cambrian time

An optimization procedure for borehole emplacement in fractured media

International Nuclear Information System (INIS)

Billaux, D.; Guerin, F.

1998-01-01

Specifying the position and orientation of the 'next borehole(s)' in a fractured medium, from prior incomplete knowledge of the fracture field and depending on the objectives assigned to this new borehole(s), is a crucial point in the iterative process of site characterization. The work described here explicitly includes site knowledge and specific objectives in a tractable procedure that checks possible borehole characteristics, and rates all trial boreholes according to their compliance with objectives. The procedure is based on the following ideas : Firstly, the optimization problem is strongly constrained, since feasible borehole head locations and borehole dips are generally limited. Secondly, a borehole is an 'access point' to the fracture network. Finally, when performing a flow or tracer test, the information obtained through the monitoring system will be best if this system detects the largest possible share of the flow induced by the test, and if it cuts the most 'interesting' flow paths. The optimization is carried out in four steps. 1) All possible borehole configurations are defined and stored. Typically, several hundred possible boreholes are created. Existing boreholes are also specified. 2) Stochastic fracture networks reproducing known site characteristics are generated. 3) A purely geometrical rating of all boreholes is used to select the 'geometrically best' boreholes or groups of boreholes. 4) Among the boreholes selected by the geometrical rating, the best one(s) is chosen by simulating the experiment for which it will be used and checking flowrates through possible boreholes. This method is applied to study the emplacement of a set of five monitoring boreholes prior to the sinking of a shaft for a planned underground laboratory in a granite massif in France (Vienne site). Twelve geometrical parameters are considered for each possible borehole. A detailed statistical study helps decide on the shape of a minimization function. This is then used

Waste Isolation Pilot Plant borehole data

International Nuclear Information System (INIS)

1995-04-01

Data pertaining to all the surface boreholes used at the WIPP site for site characterization hydrological testing and resource evaluation exist in numerous source documents. This project was initiated to develop a comprehensive data base that would include the data on all WIPP related surface boreholes from the Atomic Energy Commission, Waste Isolation Pilot Plant Energy Research and Development Administration, Department of Energy, and Hydrologic Test Borehole Programs. The data compiled from each borehole includes: operator, permit number, location, total depth, type of well, driller, drilling record, casing record, plugging schedule, and stratigraphic summary. There are six groups of boreholes contained in this data base, they are as follows: Commercially Drilled Potash Boreholes, Energy Department Wells, Geologic Exploration Boreholes, Hydrologic Test Boreholes, Potash Boreholes, and Subsurface Exploration Boreholes. There were numerous references which contained borehole data. In some cases the data found in one document was inconsistent with data in another document. In order to ensure consistency and accuracy in the data base, the same references were used for as many of the boreholes as possible. For example, all elevations and locations were taken from Compilation and Comparison of Test-Hole Location Surveys in the Vicinity of the WIPP Site. SAND 88-1065, Table 3-5. There are some sections where a data field is left blank. In this case, the information was either not applicable or was unavailable

Waste Isolation Pilot Plant borehole data

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-04-01

Data pertaining to all the surface boreholes used at the WIPP site for site characterization hydrological testing and resource evaluation exist in numerous source documents. This project was initiated to develop a comprehensive data base that would include the data on all WIPP related surface boreholes from the Atomic Energy Commission, Waste Isolation Pilot Plant Energy Research and Development Administration, Department of Energy, and Hydrologic Test Borehole Programs. The data compiled from each borehole includes: operator, permit number, location, total depth, type of well, driller, drilling record, casing record, plugging schedule, and stratigraphic summary. There are six groups of boreholes contained in this data base, they are as follows: Commercially Drilled Potash Boreholes, Energy Department Wells, Geologic Exploration Boreholes, Hydrologic Test Boreholes, Potash Boreholes, and Subsurface Exploration Boreholes. There were numerous references which contained borehole data. In some cases the data found in one document was inconsistent with data in another document. In order to ensure consistency and accuracy in the data base, the same references were used for as many of the boreholes as possible. For example, all elevations and locations were taken from Compilation and Comparison of Test-Hole Location Surveys in the Vicinity of the WIPP Site. SAND 88-1065, Table 3-5. There are some sections where a data field is left blank. In this case, the information was either not applicable or was unavailable.

HIV-negative male couples' attitudes about pre-exposure prophylaxis (PrEP) and using PrEP with a sexual agreement.

Science.gov (United States)

Mitchell, Jason W; Lee, Ji-Young; Woodyatt, Cory; Bauermeister, José; Sullivan, Patrick; Stephenson, Rob

2016-08-01

One efficacious strategy to help prevent HIV is oral pre-exposure prophylaxis (PrEP), a daily regimen of antiretroviral treatment taken by HIV-negative individuals. Two of the recommendations of Centers for Disease Control and Prevention (CDC) guidelines for PrEP pertain to being in a relationship (i.e., male couples). Despite the recognition of how primary partners in male couples' relationships shape HIV risk and CDC's PrEP guidelines, there is a paucity of data that examine HIV-negative male couples' attitudes toward PrEP use and using PrEP with a sexual agreement. A sexual agreement is an explicit agreement made between two individuals about what sex and other related behaviors may occur within and outside of their relationship. In this qualitative study, we examine HIV-negative male couples' attitudes toward PrEP use and whether they thought PrEP could be integrated into a sexual agreement. Data for this study are drawn from couple-level interviews conducted in 2014 with 29 HIV-negative male couples who had a sexual agreement and were from Atlanta or Detroit. Both passive (e.g., flyers) and active (e.g., targeted Facebook advertisements) recruitment methods were used; the sample was stratified by agreement type. Thematic analysis was applied to identify the following themes regarding HIV-negative male couples' attitudes toward PrEP use: (1) PrEP and condom use; (2) concerns about PrEP (e.g., effectiveness, side effects, and promoting sexually risky behavior); and (3) accessibility of PrEP. Some thought PrEP could be a part of couples' agreement because it could help reduce sexual anxiety and sexual risk, and would help keep the couple safe. Others described PrEP use with an agreement as something for "others". Some were also concerned that incorporating PrEP could usurp the need for a sexual agreement in a couples' relationship. These themes highlight the need to improve informational messaging and promotion efforts about PrEP among HIV-negative male couples

30 CFR 75.1322 - Stemming boreholes

Science.gov (United States)

2010-07-01

... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1322 Stemming boreholes (a... deep shall be stemmed for at least half the depth of the borehole. (f) When blasting off the solid in... water stemming bag shall be within 1/4 of an inch of the diameter of the drill bit used to drill the...

Highlights from e-EPS: EPS and EuChems are joining forces

CERN Multimedia

2013-01-01

e-EPS News is an addition to the CERN Bulletin line-up, showcasing articles from e-EPS – the European Physical Society newsletter – as part of a collaboration between the two publications.   On the occasion of the EPS Council 2013 in Strasbourg, a memorandum of understanding was signed between the European Association for Chemical and Molecular Societies (EuCheMS) and the European Physical Society (EPS) by presidents Ulrich Schubert and Luisa Cifarelli. EuCheMS and EPS share many objectives, such as community building, scientific excellence, communication and representation of their respective members to European policy makers. The two societies recognise that issues in many fields such as education, publication, support for basic sciences and frontier research are similar in their respective disciplines. They wish to combine efforts in developing and presenting common standpoints to their mutual benefit as European representatives in chemistry ...

Effects of the deviation characteristics of nuclear waste emplacement boreholes on borehole liner stresses; Yucca Mountain Project

Energy Technology Data Exchange (ETDEWEB)

Glowka, D.A.

1990-09-01

This report investigates the effects of borehole deviation on the useability of lined boreholes for the disposal of high-level nuclear waste at the proposed Yucca Mountain Repository in Nevada. Items that lead to constraints on borehole deviation include excessive stresses that could cause liner failure and possible binding of a waste container inside the liner during waste emplacement and retrieval operations. Liner stress models are developed for two general borehole configurations, one for boreholes drilled with a steerable bit and one for boreholes drilled with a non-steerable bit. Procedures are developed for calculating liner stresses that arise both during insertion of the liner into a borehole and during the thermal expansion process that follows waste emplacement. The effects of borehole curvature on the ability of the waste container to pass freely inside the liner without binding are also examined. Based on the results, specifications on borehole deviation allowances are developed for specific vertical and horizontal borehole configurations of current interest. 11 refs., 22 figs., 4 tabs.

Radiation borehole logging method

International Nuclear Information System (INIS)

Wylie, A.; Mathew, P.J.

1977-01-01

A method of obtaining an indication of the diameter of a borehole is described. The method comprises subjecting the walls of the borehole to monoenergetic gamma radiation and making measurements of the intensity of gamma radiation backscattered from the walls. The energy of the radiation is sufficiently high for the shape to be substantially independent of the density and composition of the borehole walls

Neutron borehole logging correction technique

International Nuclear Information System (INIS)

Goldman, L.H.

1978-01-01

In accordance with an illustrative embodiment of the present invention, a method and apparatus is disclosed for logging earth formations traversed by a borehole in which an earth formation is irradiated with neutrons and gamma radiation produced thereby in the formation and in the borehole is detected. A sleeve or shield for capturing neutrons from the borehole and producing gamma radiation characteristic of that capture is provided to give an indication of the contribution of borehole capture events to the total detected gamma radiation. It is then possible to correct from those borehole effects the total detected gamma radiation and any earth formation parameters determined therefrom

Borehole geophysical and flowmeter data for eight boreholes in the vicinity of Jim Woodruff Lock and Dam, Lake Seminole, Jackson County, Florida

Science.gov (United States)

Clarke, John S.; Hamrick, Michael D.; Holloway, O. Gary

2011-01-01

Borehole geophysical logs and flowmeter data were collected in April 2011 from eight boreholes to identify the depth and orientation of cavernous zones within the Miocene Tampa Limestone in the vicinity of Jim Woodruff Lock and Dam in Jackson County, Florida. These data are used to assess leakage near the dam. Each of the eight boreholes was terminated in limestone at depths ranging from 84 to 104 feet. Large cavernous zones were encountered in most of the borings, with several exceeding 20-inches in diameter. The cavernous zones generally were between 1 and 5 feet in height, but a cavern in one of the borings reached a height of about 6 feet. The resistivity of limestone layers penetrated by the boreholes generally was less than 1,000 ohm-meters. Formation resistivity near the cavernous zones did not show an appreciable contrast from surrounding bedrock, probably because the bedrock is saturated, owing to its primary permeability. Measured flow rates in the eight boreholes determined using an electromagnetic flowmeter were all less than ±0.1 liter per second. These low flow rates suggest that vertical hydraulic gradients in the boreholes are negligible and that hydraulic head in the various cavernous zones shows only minor, if any, variation.

An e-p facility for Europe. Weak interactions in e-p physics

International Nuclear Information System (INIS)

Turlay, R.

1979-01-01

We first present the recent development on an e-p collider in Europe occuring in the last year. Then a review of physics motivations for an e-p ring is discussed and developed with the latest work presented at the meeting on 'Study for an e-p Facility for Europe' held at Hamburg on April 2-3, 1979

Cleaning of boreholes

International Nuclear Information System (INIS)

Rautio, T.; Alaverronen, M.; Lohva, K.; Teivaala, V.

2004-09-01

In terms of long-term safety it is a risk that the boreholes can eventually function as short-circuits between the repository and ground surface. Therefore sealing of investigation boreholes is an important issue for the long- term safety of high-level nuclear waste repositories. In order to seal a borehole properly, the conditions of the borehole have to meet certain predetermined requirements. One of the requirements is that no instruments or materials endangering the plugging operation or the long-term function of the sealing materials, are allowed to be left in the borehole. Sometimes drilling equipment will be left in the hole or it cannot be recovered from the hole with the given constraints of time, cost and resources in spite of attempts. Additionally various measurements may be carried out in the holes after the drilling has been completed and measuring devices may get stuck in holes. Consequently cleaning of the borehole is carried out as an essential activity before sealing can be implemented. There are two common reasons identified for the drill strings to get stuck in holes. First the drill string may get stuck due to acute drilling problems. The second case is where rods are left as casing in a hole either based on the structure of the upper part of the hole or in order to support the hole. To remove the drilling or measuring equipment lost in a borehole, special techniques and professional skill must be applied. Removing measuring equipment from a hole is often demanding and time consuming work. A vital part of the cleaning operation is planning the work in advance. In order to make the plan and to select the suitable methods it is important to know the condition of the stuck material. It is also important to know the exact depth where the equipment are stuck and to have an estimate of the reasons why they have got stuck. It is also very important to know the correct dimensions of the equipment or drill string before commencing the cleaning work

Core drilling of boreholes ONK-KR1, ONK-KR2, ONK-KR3, ONK-KR4 and ONK-PVA1 in ONKALO at Olkiluoto 2005

Energy Technology Data Exchange (ETDEWEB)

Rautio, T. [Suomen Malmi Oy, Espoo (Finland)

2005-11-15

Posiva Oy submitted am application for the Decision in Principle (the final disposal facility for spent nuclear fuel at Olkiluoto, Eurajoki) to the Finnish Government in May 1999. A positive decision was made at the end of 2000 by the Government The Finnish Parliament ratified the Decision in Principle in May 2001. The decision makes it possible for Posiva to focus the confirming bedrock investigations at Olkiluoto, where in the next few years an underground rock characterisation facility, ONKALO, will be constructed. The investigation programme on the influence of grouting in ground-water chemistry will be started by Posiva. The programme consists of long-term and short-term effects of grouting and the influence of grouting at different distances from the tunnel on groundwater conditions. As a part of this Suomen Malmi oy (Smoy) core drilled four boreholes in ONKALO. The identification numbers of thee boreholes are ONK-KR1, ONK-KR2, ONK-KR3 and ONK-KR4. An additional borehole ONK-PVA1 was core drilled for long-term monitoring purposes in a place where no grouting is planned to be done.The diameter of the borehole sis 75.7 mm A set of monitoring measurements and samplings from the drilling and returning water was carried out during the drilling. The volume of the drilling water and the returning water were recorded as well as the pressure of the drilling water. The objective of these measurements was to obtain more information about bedrock and groundwater properties. Sodium fluorescein was used as a label agent in the drilling water. The volume of the used drilling water was about 16 m{sup 3} and the measured volume of the returning water was about 11 dm{sup 3} in boreholes. The deviation of the boreholes was measured with the deviation measuring instrument EMS. The main rock types are migmatitic mica gneiss and granite. Filled fractures are most common type of fractures. The average fracture frequency of the boreholes varies from 0.6 to 3.1 pcs/m. The average RQD

Core drilling of boreholes ONK-KR1, ONK-KR2, ONK-KR3, ONK-KR4 and ONK-PVA1 in ONKALO at Olkiluoto 2005

International Nuclear Information System (INIS)

Rautio, T.

2005-11-01

Posiva Oy submitted am application for the Decision in Principle (the final disposal facility for spent nuclear fuel at Olkiluoto, Eurajoki) to the Finnish Government in May 1999. A positive decision was made at the end of 2000 by the Government The Finnish Parliament ratified the Decision in Principle in May 2001. The decision makes it possible for Posiva to focus the confirming bedrock investigations at Olkiluoto, where in the next few years an underground rock characterisation facility, ONKALO, will be constructed. The investigation programme on the influence of grouting in ground-water chemistry will be started by Posiva. The programme consists of long-term and short-term effects of grouting and the influence of grouting at different distances from the tunnel on groundwater conditions. As a part of this Suomen Malmi oy (Smoy) core drilled four boreholes in ONKALO. The identification numbers of thee boreholes are ONK-KR1, ONK-KR2, ONK-KR3 and ONK-KR4. An additional borehole ONK-PVA1 was core drilled for long-term monitoring purposes in a place where no grouting is planned to be done.The diameter of the borehole sis 75.7 mm A set of monitoring measurements and samplings from the drilling and returning water was carried out during the drilling. The volume of the drilling water and the returning water were recorded as well as the pressure of the drilling water. The objective of these measurements was to obtain more information about bedrock and groundwater properties. Sodium fluorescein was used as a label agent in the drilling water. The volume of the used drilling water was about 16 m 3 and the measured volume of the returning water was about 11 dm 3 in boreholes. The deviation of the boreholes was measured with the deviation measuring instrument EMS. The main rock types are migmatitic mica gneiss and granite. Filled fractures are most common type of fractures. The average fracture frequency of the boreholes varies from 0.6 to 3.1 pcs/m. The average RQD value of

Concentration of trace metals in boreholes in the Ankobra Basin, Ghana

International Nuclear Information System (INIS)

Kortasi, B. K.

2006-01-01

Analysis of trace metals in ground water from the Ankobra basin revealed high levels of iron, manganese and aluminium. Approximately 40% of boreholes had total iron concentration exceeding 1000 μ 1 -1 (maximum WHO permissible limit). Aluminium concentration varied from 0.1 μ to 2510 μ 1 -1 with a median value of 10.0 μ 1 -1 . Approximately 20% of the boreholes had aluminium concentration exceeding the WHO maximum acceptable limit (200 μ 1 -1 ) for drinking water. Manganese concentration was in the range 6-2510 μ 1 -1 with a median of 356 μ 1 -1 . Roughly 25% of the boreholes had manganese concentrations higher that 500 μ 1 -1 , which is the WHO maximum acceptable limit for drinking water. The concentrations of mercury was higher than 1.0 μ 1 -1 (WHO maximum acceptable limit) in 60% of the boreholes during the rainy season but below detection limit in the dry season, suggesting anthropogenic origin for mercury in the groundwater. Other trace metals that occurred, but in insignificant concentration in the boreholes, include lead, arsenic, nickel and selenium. Most of the boreholes with high trace metal concentrations were located in and around the Bawdie-Bogoso-Prestea area. (au)

Product Plan of New Generation System Camera "OLYMPUS PEN E-P1"

Science.gov (United States)

Ogawa, Haruo

"OLYMPUS PEN E-P1", which is new generation system camera, is the first product of Olympus which is new standard "Micro Four-thirds System" for high-resolution mirror-less cameras. It continues good sales by the concept of "small and stylish design, easy operation and SLR image quality" since release on July 3, 2009. On the other hand, the half-size film camera "OLYMPUS PEN" was popular by the concept "small and stylish design and original mechanism" since the first product in 1959 and recorded sale number more than 17 million with 17 models. By the 50th anniversary topic and emotional value of the Olympus pen, Olympus pen E-P1 became big sales. I would like to explain the way of thinking of the product plan that included not only the simple functional value but also emotional value on planning the first product of "Micro Four-thirds System".

Using boreholes as windows into groundwater ecosystems.

Directory of Open Access Journals (Sweden)

James P R Sorensen

Full Text Available Groundwater ecosystems remain poorly understood yet may provide ecosystem services, make a unique contribution to biodiversity and contain useful bio-indicators of water quality. Little is known about ecosystem variability, the distribution of invertebrates within aquifers, or how representative boreholes are of aquifers. We addressed these issues using borehole imaging and single borehole dilution tests to identify three potential aquifer habitats (fractures, fissures or conduits intercepted by two Chalk boreholes at different depths beneath the surface (34 to 98 m. These habitats were characterised by sampling the invertebrates, microbiology and hydrochemistry using a packer system to isolate them. Samples were taken with progressively increasing pumped volume to assess differences between borehole and aquifer communities. The study provides a new conceptual framework to infer the origin of water, invertebrates and microbes sampled from boreholes. It demonstrates that pumping 5 m(3 at 0.4-1.8 l/sec was sufficient to entrain invertebrates from five to tens of metres into the aquifer during these packer tests. Invertebrates and bacteria were more abundant in the boreholes than in the aquifer, with associated water chemistry variations indicating that boreholes act as sites of enhanced biogeochemical cycling. There was some variability in invertebrate abundance and bacterial community structure between habitats, indicating ecological heterogeneity within the aquifer. However, invertebrates were captured in all aquifer samples, and bacterial abundance, major ion chemistry and dissolved oxygen remained similar. Therefore the study demonstrates that in the Chalk, ecosystems comprising bacteria and invertebrates extend from around the water table to 70 m below it. Hydrogeological techniques provide excellent scope for tackling outstanding questions in groundwater ecology, provided an appropriate conceptual hydrogeological understanding is applied.

Exploratory boreholes Juchlistock-Grimsel

International Nuclear Information System (INIS)

Mueller, W.; Keusen, H.R.

1981-11-01

The aim of the investigation was the completion of missing geological, hydrogeological and rock-mechanical data about a suitable site for the intended Nagra rock laboratory at Grimsel. To this aim, 6 horizontal boreholes of 100 m length and 86 mm diameter were drilled. The cores, extracted practically without loss, and mechanical data for the main investigation was an extensive evaluation of the lithographic discontinuities and anisotropies, because they are the main determinant of the hydrogeological conditions of the locality. The area is dominated by granites and granodiorite which are of variable biotite content, lamprophyres and aplites. The largest part of the investigated mountain region consists of compact unclefted rock. 478 of the 600 bore meters, i.e. about 80 % of the drilled mountain, have no open clefts. Only 22 of the 600 bore meters (3.6 %0 contain more than five clefts per meter, at which the open clefts in the boreholes SB1 and SB5 appear more frequently. At the remaining exploratory boreholes in 90 % of the mountain ther are no open clefts. 15 refs., 52 figs., 15 tabs

Borehole television survey

International Nuclear Information System (INIS)

Lau, J.S.O.

1980-01-01

The borehole television survey can provide a measure of the orientation, depth, width and aperture of any planar discontinuity intersected by a borehole and a technique is in an advanced stage of development by the Geological Survey of Canada (GSC) to make such measurements. Much of its practical application to date has been in crystalline rocks (plutons) at research areas pertaining to the Nuclear Waste Disposal Program in Canada. It also has many other engineering applications where bedrock stability is of particular concern. The equipment required to carry out the survey can be readily transported by two panel trucks with trailers. The components consist of a camera probe, control unit, cable storage reel, cable drive, video-tape recorder, TV monitor and two electrical generators. An inclined planar structure intersected by a borehole appears as an elliptical trace on the wall of the borehole. Such an intersection line shows on the TV monitor as a sinusoidal curve with a high point and a low point as the camera rotates through an angle of 360 degrees. The azimuth of the low point, measured by a compass in the camera probe, represents the direction of the dip of the planar structure. The angle of dip is measured midway between the high and low points or is computed from the maximum-to-minimum distance of the sinusoid and the hole diameter. These observations provide the true orientation of the planar structure if the borehole is vertical. However, if the borehole is inclined, direct observations will only provide the apparent orientation. The true orientation must thus be obtained either by means of stereographic projection or spherical trigonometry. A computer program has been written to calculate the true orientation from the apparent orientation. In the field, observation data are recorded directly on a data record sheet for keypunching and input into the computer

Geophysical borehole logging

International Nuclear Information System (INIS)

McCann, D.; Barton, K.J.; Hearn, K.

1981-08-01

Most of the available literature on geophysical borehole logging refers to studies carried out in sedimentary rocks. It is only in recent years that any great interest has been shown in geophysical logging in boreholes in metamorphic and igneous rocks following the development of research programmes associated with geothermal energy and nuclear waste disposal. This report is concerned with the programme of geophysical logging carried out on the three deep boreholes at Altnabreac, Caithness, to examine the effectiveness of these methods in crystalline rock. Of particular importance is the assessment of the performance of the various geophysical sondes run in the boreholes in relation to the rock mass properties. The geophysical data can be used to provide additional in-situ information on the geological, hydrogeological and engineering properties of the rock mass. Fracturing and weathering in the rock mass have a considerable effect on both the design parameters for an engineering structure and the flow of water through the rock mass; hence, the relation between the geophysical properties and the degree of fracturing and weathering is examined in some detail. (author)

Borehole Logging for Uranium by Gamma-Ray Spectrometry

DEFF Research Database (Denmark)

Løvborg, Leif; Nyegaard, P.; Christiansen, E. M.

1980-01-01

The resources in a large syngenetic deposit of low-grade uranium (U) ore with thorium at Kvanefjeld, South Greenland, were evaluated by spectrometric gamma-ray logging of 23 boreholes, 46 mm in diameter and 200 m deep. The borehole probe's detector contained 22 cm3 of sodium-iodide, and the photo......The resources in a large syngenetic deposit of low-grade uranium (U) ore with thorium at Kvanefjeld, South Greenland, were evaluated by spectrometric gamma-ray logging of 23 boreholes, 46 mm in diameter and 200 m deep. The borehole probe's detector contained 22 cm3 of sodium...... of the spectrometer system were determined by calculating the average number of U and thorium (Th) counts per meter of borehole and comparing these with the U-Th concentrations in 1-m sections of analyzed drill core. The sensitivity and the background count rate in the uranium window varied appreciably from one hole...

Core-logs of borehole VI down to 505 m

International Nuclear Information System (INIS)

Carlsson, L.; Olsson, T.; Stejskal, V.

1981-01-01

In the hydrogeological program of the Stripa project the vertical borehole V1 has been drilled 505.5 m. The drillcore has been logged with regard to rock characteristic, fracture frequency, dipping and filling. The results presented as cumulative fracture diagram have formed the base for subdivision of the borehole according to fracture frequency. The variation in the fracture dipping was also taken into account. Chlorite is the most common of the infilling material in the fractures. For the borehole 0-466 m the average fracture frequency is 1.46 fractures/m. Below 466 m the core is highly fractured and crushed indicating that the borehole has entered a crushed zone. Because of this the drilling is temporarily stopped. (Auth.)

Key Factors to Determine the Borehole Spacing in a Deep Borehole Disposal for HLW

International Nuclear Information System (INIS)

Lee, Jongyoul; Choi, Heuijoo; Lee, Minsoo; Kim, Geonyoung; Kim, Kyeongsoo

2015-01-01

Deep fluids also resist vertical movement because they are density stratified and reducing conditions will sharply limit solubility of most dose critical radionuclides at the depth. Finally, high ionic strengths of deep fluids will prevent colloidal transport. Therefore, as an alternative disposal concept, i.e., deep borehole disposal technology is under consideration in number of countries in terms of its outstanding safety and cost effectiveness. In this paper, the general concept for deep borehole disposal of spent fuels or high level radioactive wastes which has been developed by some countries according to the rapid advance in the development of drilling technology, as an alternative method to the deep geological disposal method, was reviewed. After then an analysis on key factors for the distance between boreholes for the disposal of HLW was carried out. In this paper, the general concept for deep borehole disposal of spent fuels or HLW wastes, as an alternative method to the deep geological disposal method, were reviewed. After then an analysis on key factors for the determining the distance between boreholes for the disposal of HLW was carried out. These results can be used for the development of the HLW deep borehole disposal system

Key Factors to Determine the Borehole Spacing in a Deep Borehole Disposal for HLW

Energy Technology Data Exchange (ETDEWEB)

Lee, Jongyoul; Choi, Heuijoo; Lee, Minsoo; Kim, Geonyoung; Kim, Kyeongsoo [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2015-05-15

Deep fluids also resist vertical movement because they are density stratified and reducing conditions will sharply limit solubility of most dose critical radionuclides at the depth. Finally, high ionic strengths of deep fluids will prevent colloidal transport. Therefore, as an alternative disposal concept, i.e., deep borehole disposal technology is under consideration in number of countries in terms of its outstanding safety and cost effectiveness. In this paper, the general concept for deep borehole disposal of spent fuels or high level radioactive wastes which has been developed by some countries according to the rapid advance in the development of drilling technology, as an alternative method to the deep geological disposal method, was reviewed. After then an analysis on key factors for the distance between boreholes for the disposal of HLW was carried out. In this paper, the general concept for deep borehole disposal of spent fuels or HLW wastes, as an alternative method to the deep geological disposal method, were reviewed. After then an analysis on key factors for the determining the distance between boreholes for the disposal of HLW was carried out. These results can be used for the development of the HLW deep borehole disposal system.

BoreholeAR: A mobile tablet application for effective borehole database visualization using an augmented reality technology

Science.gov (United States)

Lee, Sangho; Suh, Jangwon; Park, Hyeong-Dong

2015-03-01

Boring logs are widely used in geological field studies since the data describes various attributes of underground and surface environments. However, it is difficult to manage multiple boring logs in the field as the conventional management and visualization methods are not suitable for integrating and combining large data sets. We developed an iPad application to enable its user to search the boring log rapidly and visualize them using the augmented reality (AR) technique. For the development of the application, a standard borehole database appropriate for a mobile-based borehole database management system was designed. The application consists of three modules: an AR module, a map module, and a database module. The AR module superimposes borehole data on camera imagery as viewed by the user and provides intuitive visualization of borehole locations. The map module shows the locations of corresponding borehole data on a 2D map with additional map layers. The database module provides data management functions for large borehole databases for other modules. Field survey was also carried out using more than 100,000 borehole data.

Analyses of the deep borehole drilling status for a deep borehole disposal system

Energy Technology Data Exchange (ETDEWEB)

Lee, Jong Youl; Choi, Heui Joo; Lee, Min Soo; Kim, Geon Young; Kim, Kyung Su [KAERI, Daejeon (Korea, Republic of)

2016-05-15

The purpose of disposal for radioactive wastes is not only to isolate them from humans, but also to inhibit leakage of any radioactive materials into the accessible environment. Because of the extremely high level and long-time scale radioactivity of HLW(High-level radioactive waste), a mined deep geological disposal concept, the disposal depth is about 500 m below ground, is considered as the safest method to isolate the spent fuels or high-level radioactive waste from the human environment with the best available technology at present time. Therefore, as an alternative disposal concept, i.e., deep borehole disposal technology is under consideration in number of countries in terms of its outstanding safety and cost effectiveness. In this paper, the general status of deep drilling technologies was reviewed for deep borehole disposal of high level radioactive wastes. Based on the results of these review, very preliminary applicability of deep drilling technology for deep borehole disposal analyzed. In this paper, as one of key technologies of deep borehole disposal system, the general status of deep drilling technologies in oil industry, geothermal industry and geo scientific field was reviewed for deep borehole disposal of high level radioactive wastes. Based on the results of these review, the very preliminary applicability of deep drilling technology for deep borehole disposal such as relation between depth and diameter, drilling time and feasibility classification was analyzed.

Prostaglandin E2 Prevents Hyperosmolar-Induced Human Mast Cell Activation through Prostanoid Receptors EP2 and EP4

Science.gov (United States)

Torres-Atencio, Ivonne; Ainsua-Enrich, Erola; de Mora, Fernando; Picado, César; Martín, Margarita

2014-01-01

Background Mast cells play a critical role in allergic and inflammatory diseases, including exercise-induced bronchoconstriction (EIB) in asthma. The mechanism underlying EIB is probably related to increased airway fluid osmolarity that activates mast cells to the release inflammatory mediators. These mediators then act on bronchial smooth muscle to cause bronchoconstriction. In parallel, protective substances such as prostaglandin E2 (PGE2) are probably also released and could explain the refractory period observed in patients with EIB. Objective This study aimed to evaluate the protective effect of PGE2 on osmotically activated mast cells, as a model of exercise-induced bronchoconstriction. Methods We used LAD2, HMC-1, CD34-positive, and human lung mast cell lines. Cells underwent a mannitol challenge, and the effects of PGE2 and prostanoid receptor (EP) antagonists for EP1–4 were assayed on the activated mast cells. Beta-hexosaminidase release, protein phosphorylation, and calcium mobilization were assessed. Results Mannitol both induced mast cell degranulation and activated phosphatidyl inositide 3-kinase and mitogen-activated protein kinase (MAPK) pathways, thereby causing de novo eicosanoid and cytokine synthesis. The addition of PGE2 significantly reduced mannitol-induced degranulation through EP2 and EP4 receptors, as measured by beta-hexosaminidase release, and consequently calcium influx. Extracellular-signal-regulated kinase 1/2, c-Jun N-terminal kinase, and p38 phosphorylation were diminished when compared with mannitol activation alone. Conclusions Our data show a protective role for the PGE2 receptors EP2 and EP4 following osmotic changes, through the reduction of human mast cell activity caused by calcium influx impairment and MAP kinase inhibition. PMID:25329458

Characterization of crystalline rocks in deep boreholes. The Kola, Krivoy Rog and Tyrnauz boreholes

International Nuclear Information System (INIS)

1992-12-01

SKB studies, as one alternative, the feasibility of disposing of spent nuclear fuel in very deep boreholes. As a part of this work NEDRA has compiled geoscientific data from three superdeep boreholes within the former Soviet Union. The holes considered were: the Kola borehole, 12261 m deep and located on the Kola Peninsula, the Krivoy Rog borehole, 5000 m deep and located in Ukraine, and the Tyrnauz borehole, 4001 m deep and located between the Black Sea and the Caspian Sea. These boreholes all penetrate crystalline formations, but major differences are found when their tectonic environments are compared. Excluding the uppermost horizon affected by surface phenomena, data do not indicate any general correlation between depth and the state of rock fracturing, which is instead governed by site specific, lithological and tectonical factors. This applies also to fracture zones, which are found at similar frequencies at all depths. As opposed to the structural data, the hydrogeological and hydrochemical information reveals a vertical zonation, with clear similarities between the three boreholes. An upper zone with active circulation and fresh or slightly mineralized groundwaters reaches down 1000-2000 m. The interval from 1000-2000 m down to 4000-5000 m can be characterized as a transition zone with lower circulation rates and gradually increasing mineralisation. Below 4000-5000 m, strongly mineralized, stagnant, juvenile or metamorphogenic waters are found. Geothermal data verify the existence of this zonation. 28 figs, 30 tabs

PrEP (Pre-Exposure Prophylaxis) 101

Science.gov (United States)

... than 70%. Your risk of getting HIV from sex can be even lower if you combine PrEP with condoms and other prevention methods. Download PrEP 101 Consumer Info Sheet Vital Signs Fact Sheet on Daily Pill Can Prevent HIV (PrEP) Expand All Collapse All Video Introductions to PrEP What is PrEP? A Brief ...

Borehole Stability in High-Temperature Formations

Science.gov (United States)

Yan, Chuanliang; Deng, Jingen; Yu, Baohua; Li, Wenliang; Chen, Zijian; Hu, Lianbo; Li, Yang

2014-11-01

In oil and gas drilling or geothermal well drilling, the temperature difference between the drilling fluid and formation will lead to an apparent temperature change around the borehole, which will influence the stress state around the borehole and tend to cause borehole instability in high geothermal gradient formations. The thermal effect is usually not considered as a factor in most of the conventional borehole stability models. In this research, in order to solve the borehole instability in high-temperature formations, a calculation model of the temperature field around the borehole during drilling is established. The effects of drilling fluid circulation, drilling fluid density, and mud displacement on the temperature field are analyzed. Besides these effects, the effect of temperature change on the stress around the borehole is analyzed based on thermoelasticity theory. In addition, the relationships between temperature and strength of four types of rocks are respectively established based on experimental results, and thermal expansion coefficients are also tested. On this basis, a borehole stability model is established considering thermal effects and the effect of temperature change on borehole stability is also analyzed. The results show that the fracture pressure and collapse pressure will both increase as the temperature of borehole rises, and vice versa. The fracture pressure is more sensitive to temperature. Temperature has different effects on collapse pressures due to different lithological characters; however, the variation of fracture pressure is unrelated to lithology. The research results can provide a reference for the design of drilling fluid density in high-temperature wells.

Borehole camera technology and its application in the Three Gorges Project

Energy Technology Data Exchange (ETDEWEB)

Wang, C.Y.; Sheng, Q.; Ge, X.R. [Chinese Academy of Sciences, Inst. of Rock and Soil Mechanics, Wuhan (China); Law, K.T. [Carleton Univ., Ottawa, ON (Canada)

2002-07-01

The China's Three Gorges Project is the world's largest hydropower project, consisting of a 1,983-meter long and 185-meter high dam and 26 power generating units. Borehole examination has been conducted at the site to ensure stability of the slope of the ship lock used for navigation. This paper describes 2 systems for borehole inspection and viewing. Both methods of camera borehole technology provide a unique way for geologic engineers to observe the condition inside a borehole. The Axial-View Borehole Television (AVBTV) provides real-time frontal view of the borehole ahead of the probe, making it possible to detect where holes are blocked and to see cracks and other distinctive features in the strata. The Digital Panoramic Borehole Camera System (DPBCS) can collect, measure, save, analyze, manage and displace geological information about a borehole. It can also be used to determine the orientation of discontinuity, generate unrolled image and virtual core graph and conduct statistical analysis. Both camera systems have been demonstrated successfully at the Three Gorges Project for qualitative description of the borehole as well as for quantitative analysis of cracks existing in the rock. It has been determined that most of the cracks dip in the same general direction as the northern slope of the permanent ship lock of the Three Gorges Project. 12 refs., 1 tab., 9 figs.

30 CFR 57.22241 - Advance face boreholes (I-C mines).

Science.gov (United States)

2010-07-01

...) Boreholes shall be drilled in such a manner to insure that the advancing face will not accidently break into... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Advance face boreholes (I-C mines). 57.22241... Standards for Methane in Metal and Nonmetal Mines Ventilation § 57.22241 Advance face boreholes (I-C mines...

New experiences in borehole dilution techniques

International Nuclear Information System (INIS)

Umesh Chandra

1977-01-01

A study of filtration rate and direction of groundwater flow was made at various depths in borehole using bromine-82 as groundwater tracer. The filtration rates were found to vary along the depth of borehole. Vertical flow in the borehole was observed in an alluvial aquifer even after sealing the borehole by rubber packers. The filtration rates, obtained without the packer at various depths, were much less than those obtained with packer. Microscopic hydrological information was obtained around the borehole which was useful in planning a drainage system in the area. A depth was located in the borehole where vertical flow was in opposite directions. At another depth a zone of horizontal flow was observed where vertical flow was in opposite directions. The improved instrumentation used rendered the field work extremely easy quick and readily reproducible. (author)

ASSESSMENT OF HEAVY METAL STATUS OF BOREHOLES IN ...

African Journals Online (AJOL)

Osondu

2012-02-13

Feb 13, 2012 ... monitoring and assessment of boreholes mostly the indiscriminate sinking of boreholes in the ... Ethiopian Journal of Environmental Studies and Management Vol. 5 No.1 2012 ... may enter a water supply by industrial and ... issues of present day research on risk .... and pigments for paints, cement, paper,.

Borehole plugging experiment in OL-KR24 at Olkiluoto, Finland

International Nuclear Information System (INIS)

Rautio, T.

2006-04-01

Sealing of investigation boreholes has been studied by Svensk Koernbroenslehantering AB (SKB) and Posiva Oy (Posiva) as a part of final disposal research. The proposed principle is that investigation boreholes drilled at a site must not act as a continuous flow path for groundwater but be sealed to become as tight as the surrounding rock. As a part of the investigations SKB and Posiva started the third phase of the joint project 'Cleaning and sealing of investigation boreholes' in 2005. One of the sub-projects was the plugging experiment in borehole OL-KR24 at Olkiluoto. The aim of the experiment was to test all main procedures of borehole sealing concept in practise in a deep borehole. Borehole KR24 was drilled to the depth of 551.11 metres in 2003 and it was located inside the shaft profile in Onkalo. From the surface to the depth of about 120 m the borehole diameter is 98 mm. The rest of the borehole is 75.7 mm in diameter. The borehole is vertical and the inclination is quite accurately 90 degrees. The plugging experiment in borehole OL-KR24 consisted of four main activities: (1) cleaning of the borehole, (2) characterization of the borehole (3) selective stabilisation of the borehole, and (4) emplacement of plugs. The comprehensive cleaning of the borehole was to be done in the first stage to provide the basis for other activities. The aim of characterization was to study the borehole in order to determine the sections for selective stabilisation and the locations for plugs. The characterization phase consisted of caliper measurements, dummy probing and optical borehole imaging (OBI). The aim of selective stabilisation was to show that selected borehole sections can be stabilised using new techniques and methods. One borehole section was reamed from Ω 76 mm to Ω 98 mm. The reamed borehole section should have been filled with sufficient amount of cement-based material to achieve a stable 'concrete tube' after redrilling, but due to encountered problems and

Borehole Summary Report for Core Hole C4998 – Waste Treatment Plant Seismic Boreholes Project

Energy Technology Data Exchange (ETDEWEB)

Barnett, D. BRENT; Garcia, Benjamin J.

2006-12-15

Seismic borehole C4998 was cored through the upper portion of the Columbia River Basalt Group and Ellensburg Formation to provide detailed lithologic information and intact rock samples that represent the geology at the Waste Treatment Plant. This report describes the drilling of borehole C4998 and documents the geologic data collected during the drilling of the cored portion of the borehole.

30 CFR 75.388 - Boreholes in advance of mining.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Boreholes in advance of mining. 75.388 Section... of mining. (a) Boreholes shall be drilled in each advancing working place when the working place... cannot be examined, and before mining continues, a certified person shall, if possible, determine— (1...

EpsA is an essential gene in exopolysaccharide production in Lactobacillus johnsonii FI9785.

Science.gov (United States)

Dertli, Enes; Mayer, Melinda J; Colquhoun, Ian J; Narbad, Arjan

2016-07-01

Lactobacillus johnsonii FI9785 has an eps gene cluster which is required for the biosynthesis of homopolymeric exopolysaccharides (EPS)-1 and heteropolymeric EPS-2 as a capsular layer. The first gene of the cluster, epsA, is the putative transcriptional regulator. In this study we showed the crucial role of epsA in EPS biosynthesis by demonstrating that deletion of epsA resulted in complete loss of both EPS-1 and EPS-2 on the cell surface. Plasmid complementation of the epsA gene fully restored EPS production, as confirmed by transmission electron microscopy and nuclear magnetic resonance (NMR) analysis. Furthermore, this complementation resulted in a twofold increase in the expression levels of this gene, which almost doubled amounts of EPS production in comparison with the wild-type strain. Analysis of EPS by NMR showed an increased ratio of the heteropolysaccharide to homopolysaccharide in the complemented strain and allowed identification of the acetylated residue in EPS-2 as the (1,4)-linked βGlcp unit, with the acetyl group located at O-6. These findings indicate that epsA is a positive regulator of EPS production and that EPS production can be manipulated by altering its expression. © 2015 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.

Increased Eps15 homology domain 1 and RAB11FIP3 expression regulate breast cancer progression via promoting epithelial growth factor receptor recycling.

Science.gov (United States)

Tong, Dandan; Liang, Ya-Nan; Stepanova, A A; Liu, Yu; Li, Xiaobo; Wang, Letian; Zhang, Fengmin; Vasilyeva, N V

2017-02-01

Recent research indicates that the C-terminal Eps15 homology domain 1 is associated with epithelial growth factor receptor-mediated endocytosis recycling in non-small-cell lung cancer. The aim of this study was to determine the clinical significance of Eps15 homology domain 1 gene expression in relation to phosphorylation of epithelial growth factor receptor expression in patients with breast cancer. Primary breast cancer samples from 306 patients were analyzed for Eps15 homology domain 1, RAB11FIP3, and phosphorylation of epithelial growth factor receptor expression via immunohistochemistry. The clinical significance was assessed via a multivariate Cox regression analysis, Kaplan-Meier curves, and the log-rank test. Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor were upregulated in 60.46% (185/306) and 53.92% (165/306) of tumor tissues, respectively, as assessed by immunohistochemistry. The statistical correlation analysis indicated that Eps15 homology domain 1 overexpression was positively correlated with the increases in phosphorylation of epithelial growth factor receptor ( r = 0.242, p breast cancer for the overall survival in the total, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. However, the use of combined expression of Eps15 homology domain 1 and phosphorylation of epithelial growth factor receptor markers is more effective for the disease-free survival in the overall population, chemotherapy, and human epidermal growth factor receptor 2 (-) groups. Moreover, the combined markers are also significant prognostic markers of breast cancer in the human epidermal growth factor receptor 2 (+), estrogen receptor (+), and estrogen receptor (-) groups. Eps15 homology domain 1 has a tumor suppressor function, and the combined marker of Eps15 homology domain 1/phosphorylation of epithelial growth factor receptor expression was identified as a better prognostic marker in breast cancer diagnosis

Abnormal placental development and early embryonic lethality in EpCAM-null mice.

Directory of Open Access Journals (Sweden)

Keisuke Nagao

Full Text Available BACKGROUND: EpCAM (CD326 is encoded by the tacstd1 gene and expressed by a variety of normal and malignant epithelial cells and some leukocytes. Results of previous in vitro experiments suggested that EpCAM is an intercellular adhesion molecule. EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells. METHODOLOGY/PRINCIPAL FINDINGS: To gain insights into EpCAM function in vivo, we generated EpCAM -/- mice utilizing an embryonic stem cell line with a tacstd1 allele that had been disrupted. Gene trapping resulted in a protein comprised of the N-terminus of EpCAM encoded by 2 exons of the tacstd1 gene fused in frame to betageo. EpCAM +/- mice were viable and fertile and exhibited no obvious abnormalities. Examination of EpCAM +/- embryos revealed that betageo was expressed in several epithelial structures including developing ears (otocysts, eyes, branchial arches, gut, apical ectodermal ridges, lungs, pancreas, hair follicles and others. All EpCAM -/- mice died in utero by E12.5, and were small, developmentally delayed, and displayed prominent placental abnormalities. In developing placentas, EpCAM was expressed throughout the labyrinthine layer and by spongiotrophoblasts as well. Placentas of EpCAM -/- embryos were compact, with thin labyrinthine layers lacking prominent vascularity. Parietal trophoblast giant cells were also dramatically reduced in EpCAM -/- placentas. CONCLUSION: EpCAM was required for differentiation or survival of parietal trophoblast giant cells, normal development of the placental labyrinth and establishment of a competent maternal-fetal circulation. The findings in EpCAM-reporter mice suggest involvement of this molecule in development of vital organs including the gut, kidneys, pancreas, lungs, eyes, and limbs.

Abnormal placental development and early embryonic lethality in EpCAM-null mice.

Science.gov (United States)

Nagao, Keisuke; Zhu, Jianjian; Heneghan, Mallorie B; Hanson, Jeffrey C; Morasso, Maria I; Tessarollo, Lino; Mackem, Susan; Udey, Mark C

2009-12-31

EpCAM (CD326) is encoded by the tacstd1 gene and expressed by a variety of normal and malignant epithelial cells and some leukocytes. Results of previous in vitro experiments suggested that EpCAM is an intercellular adhesion molecule. EpCAM has been extensively studied as a potential tumor marker and immunotherapy target, and more recent studies suggest that EpCAM expression may be characteristic of cancer stem cells. To gain insights into EpCAM function in vivo, we generated EpCAM -/- mice utilizing an embryonic stem cell line with a tacstd1 allele that had been disrupted. Gene trapping resulted in a protein comprised of the N-terminus of EpCAM encoded by 2 exons of the tacstd1 gene fused in frame to betageo. EpCAM +/- mice were viable and fertile and exhibited no obvious abnormalities. Examination of EpCAM +/- embryos revealed that betageo was expressed in several epithelial structures including developing ears (otocysts), eyes, branchial arches, gut, apical ectodermal ridges, lungs, pancreas, hair follicles and others. All EpCAM -/- mice died in utero by E12.5, and were small, developmentally delayed, and displayed prominent placental abnormalities. In developing placentas, EpCAM was expressed throughout the labyrinthine layer and by spongiotrophoblasts as well. Placentas of EpCAM -/- embryos were compact, with thin labyrinthine layers lacking prominent vascularity. Parietal trophoblast giant cells were also dramatically reduced in EpCAM -/- placentas. EpCAM was required for differentiation or survival of parietal trophoblast giant cells, normal development of the placental labyrinth and establishment of a competent maternal-fetal circulation. The findings in EpCAM-reporter mice suggest involvement of this molecule in development of vital organs including the gut, kidneys, pancreas, lungs, eyes, and limbs.

Prostaglandin E2-Induced COX-2 Expressions via EP2 and EP4 Signaling Pathways in Human LoVo Colon Cancer Cells

Directory of Open Access Journals (Sweden)

Hsi-Hsien Hsu

2017-05-01

Full Text Available Metastasis is the most dangerous risk faced by patients with hereditary non-polyposis colon cancer (HNPCC. The expression of matrix metalloproteinases (MMPs has been observed in several types of human cancers and regulates the efficacy of many therapies. Here, we show that treatment with various concentrations of prostaglandin E2 (PGE2; 0, 1, 5 or 10 μM promotes the migration ability of the human LoVo colon cancer cell line. As demonstrated by mRNA and protein expression analyses, EP2 and EP4 are the major PGE2 receptors expressed on the LoVo cell membrane. The Phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K/Akt cell survival pathway was upregulated by EP2 and EP4 activation. Following the activation of the PI3K/Akt pathway, β-catenin translocated into the nucleus and triggered COX2 transcription via LEF-1 and TCF-4 and its subsequent translation. COX2 expression correlated with the elevation in the migration ability of LoVo cells. The experimental evidence shows a possible mechanism by which PGE2 induces cancer cell migration and further suggests PGE2 to be a potential therapeutic target in colon cancer metastasis. On inhibition of PGE2, in order to determine the downstream pathway, the levels of PI3K/Akt pathway were suppressed and the β-catenin expression was also modulated. Inhibition of EP2 and EP4 shows that PGE2 induces protein expression of COX-2 through EP2 and EP4 receptors in LoVo colon cancer cells.

Feasibility study for a deep thermal exchanger at Soultz-sous-Forets (Alsace, France)

International Nuclear Information System (INIS)

Elsass, P.; Aquilina, L.; Beauce, A.; Benderitter, Y.; Fabriol, H.; Genter, A.; Pauwels, H.

1995-01-01

This project is part of the European program on deep geothermics research. It consists in the interpretation of structural, geochemical and geophysical data collected on Soultz site, in the simulation and the experimental validation of rock-fluid interactions in the exchanger, and in the simulation of structural, thermal and hydraulic characteristics of the site. The principal event in this project for 1994 was the starting of the GPK2 drilling for a characterization of the hydraulic connections at a 3000 m depth with the existing GPK1 borehole. The interpretation of borehole images of structures and alterations in GPK1 has led to the construction of a structural model of the granitic massif characterized by large N-S and NW-SE accidents in which hydrothermal alteration has developed. The localisation of micro-earthquakes induced by the hydraulic injections in GPK1 shows a well-structured cloud due to the interference between the stress field and the faulted structures. The geochemical composition of fluids produced by GPK1 after stimulation shows a rapid replacement of the injected fresh water by salty fluids. These fluids are supposed to belong to hydrothermal convection loops installed in fractured zones and connected to the overlying Buntsandstein sandstone reservoir. (J.S.). 4 figs

Development and labeling of EP-00652218 analogues, NK1 receptors antagonist, for PET and SPECT imaging

International Nuclear Information System (INIS)

Bagot-Gueret, C.

2001-12-01

The aim of this work was the synthesis and radiosynthesis of compounds labelled either with a positron emitter (fluorine-18, t 1/2 = 109 minutes) or with a gamma emitter (iodine-123, t 1/2 = 16.2 hours), for Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) studies. EP-00652218 is a novel potent antagonist, with a sub-nano-molar affinity towards the NK 1 receptors. In order to develop ligands that could be used either in PET or SPECT, we undertook the synthesis of poly-halogenated analogues of EP-00652218. Compound 17 was synthesized through two different synthetic pathways. A series of original compounds has been obtained from compound 17 by halogen exchanges on the naphthyridone or the benzene ring. These molecules were tested to determine their in vitro affinity towards NK 1 receptors. Compound 21 was labelled with fluorine-18 in 135 minutes and with a 20% radiochemical yield. Compound 26 was radioiodinated following reaction with Na 125 I (t 1/2 = 60.14 days) in a 18% radiochemical yield. Despite expectation, these analogues of EP-00652218 exhibited an insufficient affinity for NK 1 receptors (IC 50 = 10 -7 M) and thus unlikely usable for in vivo studies with PET and SPECT. (author)

Analysis of borehole-radar reflection logs from selected HC boreholes at the Project Shoal area, Churchill County, Nevada

Science.gov (United States)

Lane, J.W.; Joesten, P.K.; Pohll, G.M.; Mihevic, Todd

2001-01-01

Single-hole borehole-radar reflection logs were collected and interpreted in support of a study to characterize ground-water flow and transport at the Project Shoal Area (PSA) in Churchill County, Nevada. Radar logging was conducted in six boreholes using 60-MHz omni-directional electric-dipole antennas and a 60-MHz magnetic-dipole directional receiving antenna.Radar data from five boreholes were interpreted to identify the location, orientation, estimated length, and spatial continuity of planar reflectors present in the logs. The overall quality of the radar data is marginal and ranges from very poor to good. Twenty-seven reflectors were interpreted from the directional radar reflection logs. Although the range of orientation interpreted for the reflectors is large, a significant number of reflectors strike northeast-southwest and east-west to slightly northwest-southeast. Reflectors are moderate to steeply dipping and reflector length ranged from less than 7 m to more than 133 m.Qualitative scores were assigned to each reflector to provide a sense of the spatial continuity of the reflector and the characteristics of the field data relative to an ideal planar reflector (orientation score). The overall orientation scores are low, which reflects the general data quality, but also indicates that the properties of most reflectors depart from the ideal planar case. The low scores are consistent with reflections from fracture zones that contain numerous, closely spaced, sub-parallel fractures.Interpretation of borehole-radar direct-wave velocity and amplitude logs identified several characteristics of the logged boreholes: (1) low-velocity zones correlate with decreased direct-wave amplitude, indicating the presence of fracture zones; (2) direct-wave amplitude increases with depth in three of the boreholes, suggesting an increase in electrical resistivity with depth resulting from changes in mineral assemblage or from a decrease in the specific conductance of ground

Epstein-Barr Virus Nuclear Antigen Leader Protein Coactivates EP300.

Science.gov (United States)

Wang, Chong; Zhou, Hufeng; Xue, Yong; Liang, Jun; Narita, Yohei; Gerdt, Catherine; Zheng, Amy Y; Jiang, Runsheng; Trudeau, Stephen; Peng, Chih-Wen; Gewurz, Benjamin E; Zhao, Bo

2018-05-01

Epstein-Barr virus nuclear antigen (EBNA) leader protein (EBNALP) is one of the first viral genes expressed upon B-cell infection. EBNALP is essential for EBV-mediated B-cell immortalization. EBNALP is thought to function primarily by coactivating EBNA2-mediated transcription. Chromatin immune precipitation followed by deep sequencing (ChIP-seq) studies highlight that EBNALP frequently cooccupies DNA sites with host cell transcription factors (TFs), in particular, EP300, implicating a broader role in transcription regulation. In this study, we investigated the mechanisms of EBNALP transcription coactivation through EP300. EBNALP greatly enhanced EP300 transcription activation when EP300 was tethered to a promoter. EBNALP coimmunoprecipitated endogenous EP300 from lymphoblastoid cell lines (LCLs). EBNALP W repeat serine residues 34, 36, and 63 were required for EP300 association and coactivation. Deletion of the EP300 histone acetyltransferase (HAT) domain greatly reduced EBNALP coactivation and abolished the EBNALP association. An EP300 bromodomain inhibitor also abolished EBNALP coactivation and blocked the EP300 association with EBNALP. EBNALP sites cooccupied by EP300 had significantly higher ChIP-seq signals for sequence-specific TFs, including SPI1, RelA, EBF1, IRF4, BATF, and PAX5. EBNALP- and EP300-cooccurring sites also had much higher H3K4me1 and H3K27ac signals, indicative of activated enhancers. EBNALP-only sites had much higher signals for DNA looping factors, including CTCF and RAD21. EBNALP coactivated reporters under the control of NF-κB or SPI1. EP300 inhibition abolished EBNALP coactivation of these reporters. Clustered regularly interspaced short palindromic repeat interference targeting of EBNALP enhancer sites significantly reduced target gene expression, including that of EP300 itself. These data suggest a previously unrecognized mechanism by which EBNALP coactivates transcription through subverting of EP300 and thus affects the expression of

Deep Borehole Field Test Research Activities at LBNL

Energy Technology Data Exchange (ETDEWEB)

Dobson, Patrick [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Tsang, Chin-Fu [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kneafsey, Timothy [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Borglin, Sharon [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Piceno, Yvette [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Andersen, Gary [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Nakagawa, Seiji [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Nihei, Kurt [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rutqvist, Jonny [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Doughty, Christine [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Reagan, Matthew [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2016-08-19

The goal of the U.S. Department of Energy Used Fuel Disposition’s (UFD) Deep Borehole Field Test is to drill two 5 km large-diameter boreholes: a characterization borehole with a bottom-hole diameter of 8.5 inches and a field test borehole with a bottom-hole diameter of 17 inches. These boreholes will be used to demonstrate the ability to drill such holes in crystalline rocks, effectively characterize the bedrock repository system using geophysical, geochemical, and hydrological techniques, and emplace and retrieve test waste packages. These studies will be used to test the deep borehole disposal concept, which requires a hydrologically isolated environment characterized by low permeability, stable fluid density, reducing fluid chemistry conditions, and an effective borehole seal. During FY16, Lawrence Berkeley National Laboratory scientists conducted a number of research studies to support the UFD Deep Borehole Field Test effort. This work included providing supporting data for the Los Alamos National Laboratory geologic framework model for the proposed deep borehole site, conducting an analog study using an extensive suite of geoscience data and samples from a deep (2.5 km) research borehole in Sweden, conducting laboratory experiments and coupled process modeling related to borehole seals, and developing a suite of potential techniques that could be applied to the characterization and monitoring of the deep borehole environment. The results of these studies are presented in this report.

Deep Borehole Field Test Research Activities at LBNL

International Nuclear Information System (INIS)

Dobson, Patrick; Tsang, Chin-Fu; Kneafsey, Timothy; Borglin, Sharon; Piceno, Yvette; Andersen, Gary; Nakagawa, Seiji; Nihei, Kurt; Rutqvist, Jonny; Doughty, Christine; Reagan, Matthew

2016-01-01

The goal of the U.S. Department of Energy Used Fuel Disposition's (UFD) Deep Borehole Field Test is to drill two 5 km large-diameter boreholes: a characterization borehole with a bottom-hole diameter of 8.5 inches and a field test borehole with a bottom-hole diameter of 17 inches. These boreholes will be used to demonstrate the ability to drill such holes in crystalline rocks, effectively characterize the bedrock repository system using geophysical, geochemical, and hydrological techniques, and emplace and retrieve test waste packages. These studies will be used to test the deep borehole disposal concept, which requires a hydrologically isolated environment characterized by low permeability, stable fluid density, reducing fluid chemistry conditions, and an effective borehole seal. During FY16, Lawrence Berkeley National Laboratory scientists conducted a number of research studies to support the UFD Deep Borehole Field Test effort. This work included providing supporting data for the Los Alamos National Laboratory geologic framework model for the proposed deep borehole site, conducting an analog study using an extensive suite of geoscience data and samples from a deep (2.5 km) research borehole in Sweden, conducting laboratory experiments and coupled process modeling related to borehole seals, and developing a suite of potential techniques that could be applied to the characterization and monitoring of the deep borehole environment. The results of these studies are presented in this report.

Cement thickness measurements in cased boreholes

International Nuclear Information System (INIS)

Wahl, J.S.; Schuster, N.A.

1978-01-01

Methods and apparatus are provided for logging a borehole having solid matter along at least a portion of the wall thereof. Gamma radiation is emitted from the borehole into the surrounding media, and the amount of radiation which returns to the borehole is measured by three detectors located at different distances from the source of radiation, so as to be primarily sensitive to radiation which has respectively penetrated to three different depths in the surrounding media. The thickness of the solid matter on the borehole wall is then determined from the three gamma radiation measurements

Pesticides analysed in rainwater in Alsace region (Eastern France): Comparison between urban and rural sites

Science.gov (United States)

Scheyer, Anne; Morville, Stéphane; Mirabel, Philippe; Millet, Maurice

Current-used pesticides commonly applied in Alsace region (Eastern France) on diverse crops (maize, vineyard, vegetables, etc.) were analysed, together with Lindane, in rainwater between January 2002 and June 2003 simultaneously on two sites situated in a typical rural (Erstein, France) and urban area (Strasbourg, France). Rainwater samples were collected on a weekly basis by using two automatic wet only collectors associated with an open collector for the measurement of rainwater height. Pesticides were analysed by GC-MSMS and extracted from rainwater by SPME. Two runs were performed. The first one was performed by using a PDMS (100 μm) fibre for pesticides where direct injection into GC is possible (alachlor, atrazine, azinphos-ethyl, azinphos-methyl, captan, chlorfenvinphos, dichlorvos, diflufenican, α- and β-endosulfan, iprodione, lindane, metolachlor, mevinphos, parathion-methyl, phosalone, phosmet, tebuconazole, triadimefon and trifluralin). The second run was performed by using PDMS/DVB fibre and this run concerns pesticides where a preliminary derivatisation step with pentafluorobenzylbromide (PFBBr) is required for very low volatiles (bromoxynil,2,4-MCPA, MCPP and 2,4-D) or thermo labiles (chlorotoluron, diuron and isoproturon) pesticides. Results showed that the more concentrated pesticides detected were those used as herbicides in large quantities in Alsace region for maize crops (alachlor, metolachlor and atrazine). Maximum concentrations for these herbicides have been measured during intensive applications periods on maize crops following by rapid decrease immediately after use. For Alachlor, most important peaks have been observed between 21 and 28 April 2003 (3327 ng L -1 at Erstein and 5590 ng L -1 at Strasbourg). This is also the case for Metolachlor where most important peak was observed during the same week. Concentrations of pesticides measured out of application periods were very low for many pesticides and some others where never detected

Borehole logging in uranium exploration

International Nuclear Information System (INIS)

Kulkarni, N.H.

1992-01-01

The ultimate objective of exploration by drilling as far as Atomic Minerals Division is concerned is to locate the ore zone in the subsurface, draw samples and analyze them for their metal content. The presence of the ore zone is also indicated by gamma-ray logging of the borehole. A gamma-ray detector is lowered in the borehole and precise depth and grade of the ore zone is established. This helps the geologist in correlating the ore horizon with the surface outcrop or the ore zone intercepted in adjoining boreholes and in deciding about further drilling and location of boreholes. Most commonly, total gamma measurements are made although some units capable of measuring the gamma-ray spectrum are also in use. It is possible to know if the mineralization is due to uranium without waiting for the laboratory results. The present write up gives a brief account of the principles, equipment and methods of borehole gamma-ray logging including density and self-potential logging. (author). 8 refs., 5 figs

Biodistribution studies of epithelial cell adhesion molecule (EpCAM)-directed monoclonal antibodies in the EpCAM-transgenic mouse tumor model

NARCIS (Netherlands)

Kosterink, Jos G. W.; McLaughlin, Pamela M. J.; Lub-de Hooge, Marjolijn N.; Hendrikse, Harry H.; Van Zanten, Jacoba; Van Garderen, Evert; Harmsen, Martin C.; De Leij, Lou F. M. H.

2007-01-01

The human pancarcinoma-associated epithelial cell adhesion molecule (EpCAM) (EGP-2, CO17-1A) is a well-known target for carcinoma-directed immunotherapy. Mouse-derived mAbs directed to EpCAM have been used to treat colon carcinoma patients showing well-tolerable toxic side effects but limited

Validation of a 1DL earliness per se (eps) flowering QTL in bread wheat (Triticum aestivum).

Science.gov (United States)

Zikhali, Meluleki; Leverington-Waite, Michelle; Fish, Lesley; Simmonds, James; Orford, Simon; Wingen, Luzie U; Goram, Richard; Gosman, Nick; Bentley, Alison; Griffiths, Simon

2014-01-01

Vernalization, photoperiod and the relatively poorly defined earliness per se ( eps ) genes regulate flowering in plants. We report here the validation of a major eps quantitative trait locus (QTL) located on wheat 1DL using near isogenic lines (NILs). We used four independent pairs of NILs derived from a cross between Spark and Rialto winter wheat varieties, grown in both the field and controlled environments. NILs carrying the Spark allele, defined by QTL flanking markers Xgdm111 and Xbarc62 , consistently flowered 3-5 days earlier when fully vernalized relative to those with the Rialto. The effect was independent of photoperiod under field conditions, short days (10-h light), long days (16-h light) and very long days (20-h light). These results validate our original QTL identified using doubled haploid (DH) populations. This QTL represents variation maintained in elite north-western European winter wheat germplasm. The two DH lines used to develop the NILs, SR9 and SR23 enabled us to define the location of the 1DL QTL downstream of marker Xgdm111 . SR9 has the Spark 1DL arm while SR23 has a recombinant 1DL arm with the Spark allele from Xgdm111 to the distal end. Our work suggests that marker assisted selection of eps effects is feasible and useful even before the genes are cloned. This means eps genes can be defined and positionally cloned in the same way as the photoperiod and vernalization genes have been. This validation study is a first step towards fine mapping and eventually cloning the gene directly in hexaploid wheat.

Difference flow measurements in borehole KOV01 at Oskarshamn

International Nuclear Information System (INIS)

Poellaenen, J.; Rouhiainen, P.

2001-09-01

Posiva Flow Log/Difference Flow method can be used for relatively fast determination of hydraulic conductivity and hydraulic head in fractures or fractured zones in cored boreholes. This report presents the principles of the method as well as the results of the measurements carried out in borehole KOV01 at Oskarshamn in February and March 2001. The aim of the measurements presented in this report was to determine the depth and flow rate of flowing fractures in borehole KOV01 prior to groundwater sampling. The measurements in borehole KOV01 were carried out between 100-1000 m depth using the so called detailed flow logging mode; the flow rate into a 5 m long test section was measured. Detailed flow logging was repeated at the location of the detected flow anomalies using 0.5 m section length and 0.1 m point intervals. The borehole was pumped during these measurements. The occurrence of saline water in the borehole was studied by electric conductivity measurements. The flow guide encloses also an electrode for measuring of single point resistance of the bedrock. It was measured with 0.01 m point intervals during the detailed flow logging. Depth calibration was made on the basis of the known depth marks in the borehole. The depth marks were detected by caliper measurements and by single point resistance measurements

Logs of wells and boreholes drilled during hydrogeologic studies at Lawrence Livermore National Laboratory Site 300, January 1, 1991--September 1, 1992

International Nuclear Information System (INIS)

Crow, N.B.; McConihe, W.L.

1992-01-01

Lawrence Livermore National Laboratory (LLNL) Site 300 is located in the Altamont Hills between Livermore and Tracy, about 18 road miles southeast of Livermore, California. The site is used as a test facility to support national defense research carried out by LLNL. This Addendum 2 to the Logs of Wells and Boreholes Drilled During Hydrogeologic Studies at Lawrence Livermore National Laboratory Site 300 presents hydrogeologic logs for monitor wells and boreholes drilled primarily between January 1, 1991 and September 1, 1992. Some logs drilled earlier and not incorporated in earlier volumes of this document are also included here. A small number of logs drilled before September 1, 1992, are not available at the time of closing the report for publication of this volume (Addendum 2), but will be included in subsequent documents. By September 1, 1992, a total of 495 monitor wells and 285 exploratory boreholes had been drilled at Site 300 since the beginning of hydrogeologic studies in 1982. The primary purpose of these logs is to document lithologic and hydrogeologic conditions together with well completion information. For this reason, not all chemical analytical data are presented. These logs report concentrations of only the most commonly encountered volatile organic compounds, trace metals, and radionuclides detected in ground water and soil samples collected during drilling

The 1.1-Ga Midcontinent Rift System, central North America: sedimentology of two deep boreholes, Lake Superior region

Science.gov (United States)

Ojakangas, Richard W.; Dickas, Albert B.

2002-03-01

The Midcontinent Rift System (MRS) of central North America is a 1.1-Ga, 2500-km long structural feature that has been interpreted as a triple-junction rift developed over a mantle plume. As much as 20 km of subaerial lava flows, mainly flood basalts, are overlain by as much as 10 km of sedimentary rocks that are mostly continental fluvial red beds. This rock sequence, known as the Keweenawan Supergroup, has been penetrated by a few deep boreholes in the search for petroleum. In this paper, two deep boreholes in the Upper Peninsula of Michigan are described in detail for the first time. Both the Amoco Production #1-29R test, herein referred to as the St. Amour well, and the nearby Hickey Creek well drilled by Cleveland Cliffs Mining Services, were 100% cored. The former is 7238 ft (2410 m) deep and the latter is 5345 ft (1780 m) deep. The entirety of the stratigraphic succession of the Hickey Creek core correlates very well with the upper portion of the St. Amour core, as determined by core description and point-counting of 43 thin sections selected out of 100 studied thin sections. Two Lower Paleozoic units and two Keweenawan red bed units—the Jacobsville Sandstone and the underlying Freda Sandstone—are described. The Jacobsville is largely a feldspatholithic sandstone and the Freda is largely a lithofeldspathic sandstone. Below the Freda, the remaining footage of the St. Amour core consists of a thick quartzose sandstone unit that overlies a heterogenous unit of intercalated red bed units of conglomerate, sandstone, siltstone, and shale; black shale; individual basalt flows; and a basal ignimbritic rhyolite. This lower portion of the St. Amour core presents an enigma, as it correlates very poorly with other key boreholes located to the west and southwest. While a black shale sequence is similar to the petroleum-bearing Nonesuch Formation farther west, there is no conglomerate unit to correlate with the Copper Harbor Conglomerate. Other key boreholes are

Deep Drilling Into the Chicxulub Impact Crater: Pemex Oil Exploration Boreholes Revisited

Science.gov (United States)

Fucugauchi, J. U.; Perez-Cruz, L.

2007-05-01

The Chicxulub structure was recognized in the 1940´s from gravity anomalies in oil exploration surveys by Pemex. Geophysical anomalies occur over the carbonate platform in NW Yucatan, where density and magnetic susceptibility contrasts with the carbonates suggested a buried igneous complex or basement uplift. The exploration program developed afterwards included several boreholes, starting with the Chicxulub-1 in 1952 and eventually comprising eight deep boreholes completed through the 1970s. The investigations showing Chicxulub as a large impact crater formed at the K/T boundary have relayed on the Pemex decades-long exploration program. Despite frequent reference to Pemex information, original data have not been openly available for detailed evaluation and incorporation with results from recent efforts. Logging data and core samples remain to be analyzed, reevaluated and integrated in the context of recent marine, aerial and terrestrial geophysical surveys and the drilling/coring projects of UNAM and ICDP. In this presentation we discuss the paleontological data, stratigraphic columns and geophysical logs for the Chicxulub-1 (1582m), Sacapuc-1 (1530m), Yucatan-6 (1631m) and Ticul-1 (3575m) boreholes. These boreholes remain the deepest ones drilled in Chicxulub and the only ones providing samples of the melt-rich breccias and melt sheet. Other boreholes include the Y1 (3221m), Y2 (3474m), Y4 (2398m) and Y5A (3003m), which give information on pre-impact stratigraphy and crystalline basement. We concentrate on log and microfossil data, stratigraphic columns, lateral correlation, integration with UNAM and ICDP borehole data, and analyses of sections of melt, impact breccias and basal Paleocene carbonates. Current plans for deep drilling in Chicxulub crater focus in the peak ring zone and central sector, with proposed marine and on-land boreholes to the IODP and ICDP programs. Future ICDP borehole will be located close to Chicxulub-1 and Sacapuc-1, which intersected

Analysis of borehole-radar reflection logs from selected HC boreholes at the Project Shoal area, Churchill County, Nevada; TOPICAL

International Nuclear Information System (INIS)

Lane, J.W. Jr.; Joesten, P.K.; Pohll, Greg; Mihevic, Todd

2001-01-01

Single-hole borehole-radar reflection logs were collected and interpreted in support of a study to characterize ground-water flow and transport at the Project Shoal Area (PSA) in Churchill County, Nevada. Radar logging was conducted in six boreholes using 60-MHz omni-directional electric-dipole antennas and a 60-MHz magnetic-dipole directional receiving antenna. Radar data from five boreholes were interpreted to identify the location, orientation, estimated length, and spatial continuity of planar reflectors present in the logs. The overall quality of the radar data is marginal and ranges from very poor to good. Twenty-seven reflectors were interpreted from the directional radar reflection logs. Although the range of orientation interpreted for the reflectors is large, a significant number of reflectors strike northeast-southwest and east-west to slightly northwest-southeast. Reflectors are moderate to steeply dipping and reflector length ranged from less than 7 m to more than 133 m. Qualitative scores were assigned to each reflector to provide a sense of the spatial continuity of the reflector and the characteristics of the field data relative to an ideal planar reflector (orientation score). The overall orientation scores are low, which reflects the general data quality, but also indicates that the properties of most reflectors depart from the ideal planar case. The low scores are consistent with reflections from fracture zones that contain numerous, closely spaced, sub-parallel fractures. Interpretation of borehole-radar direct-wave velocity and amplitude logs identified several characteristics of the logged boreholes: (1) low-velocity zones correlate with decreased direct-wave amplitude, indicating the presence of fracture zones; (2) direct-wave amplitude increases with depth in three of the boreholes, suggesting an increase in electrical resistivity with depth resulting from changes in mineral assemblage or from a decrease in the specific conductance of ground

Druhý Čep

Czech Academy of Sciences Publication Activity Database

Kubíček, Tomáš

2014-01-01

Roč. 62, č. 1 (2014), s. 35-45 ISSN 0009-0468 R&D Projects: GA ČR GAP406/11/1421 Institutional support: RVO:68378068 Keywords : Czech literature * modern prose * Čep, Jan * narrative analysis Subject RIV: AJ - Letters, Mass-media, Audiovision

Borehole DC-12 hydrostratigraphic chart

International Nuclear Information System (INIS)

Gephart, R.E.

1981-09-01

This hydrostratigraphic chart identifies the basic stratigraphy and preliminary hydrologic testing results for Borehole DC-12. This borehole was cored through the Saddle Mountains and Wanapum basalt formations and into the Grande Ronde. Selected zones were hydrologically tested during coring

Borehole DC-14 hydrostratigraphic chart

International Nuclear Information System (INIS)

Gephart, R.E.

1981-09-01

This hydrostratigraphic chart identifies the basic stratigraphy and preliminary hydrologic testing results for Borehole DC-14. This borehole was cored through the Saddle Mountains and Wanapum basalt formations and into the Grande Ronde. Selected zones were hydrologically tested during coring

Borehole DC-15 hydrostratigraphic chart

International Nuclear Information System (INIS)

Gephart, R.E.

1981-09-01

This hydrostratigraphic chart identifies the basic stratigraphy and preliminary hydrologic testing results for Borehole DC-15. This borehole was cored through the Saddle Mountains and Wanapum basalt formations and into the Grande Ronde. Selected zones were hydrologically tested during coring

High-Intensity Laser Diagnostics for OMEGA EP

International Nuclear Information System (INIS)

Bromage, J.; Zuegel, J.D.; Bahk, S.-W.; Vickery, D.S.; Waxer, L.J.; Irwin, D.; Bagnoud, V.; Boni, R.; Moore, M.D.; Junquist, R.; Stoeckl, C.

2006-01-01

OMEGA EP is a new high-energy petawatt laser system under construction at the University of Rochester's Laboratory for Laser Energetics. This paper describes our designs for two diagnostics critical to OMEGA EP's mission. The focal-spot diagnostic (FSD) is responsible for characterizing the focal spot of OMEGA EP's off-axis parabolic mirror at full energy. The ultrafast temporal diagnostic (UTD) is responsible for characterizing pulse shapes of full-energy target shots ranging in width from <1 to 100 ps as well as setting the desired pulse width before the shot. These diagnostics will enable, for the first time, complete spatial and temporal characterization of the focus of a high-energy petawatt laser at full energy

Prostaglandin E1 and Its Analog Misoprostol Inhibit Human CML Stem Cell Self-Renewal via EP4 Receptor Activation and Repression of AP-1.

Science.gov (United States)

Li, Fengyin; He, Bing; Ma, Xiaoke; Yu, Shuyang; Bhave, Rupali R; Lentz, Steven R; Tan, Kai; Guzman, Monica L; Zhao, Chen; Xue, Hai-Hui

2017-09-07

Effective treatment of chronic myelogenous leukemia (CML) largely depends on the eradication of CML leukemic stem cells (LSCs). We recently showed that CML LSCs depend on Tcf1 and Lef1 factors for self-renewal. Using a connectivity map, we identified prostaglandin E1 (PGE1) as a small molecule that partly elicited the gene expression changes in LSCs caused by Tcf1/Lef1 deficiency. Although it has little impact on normal hematopoiesis, we found that PGE1 treatment impaired the persistence and activity of LSCs in a pre-clinical murine CML model and a xenograft model of transplanted CML patient CD34 + stem/progenitor cells. Mechanistically, PGE1 acted on the EP4 receptor and repressed Fosb and Fos AP-1 factors in a β-catenin-independent manner. Misoprostol, an FDA-approved EP4 agonist, conferred similar protection against CML. These findings suggest that activation of this PGE1-EP4 pathway specifically targets CML LSCs and that the combination of PGE1/misoprostol with conventional tyrosine-kinase inhibitors could provide effective therapy for CML. Copyright © 2017 Elsevier Inc. All rights reserved.

Active Control of 2/1 Magnetic Islands in the HBT-EP Tokamak

International Nuclear Information System (INIS)

Navratil, G.A.; Cates, C.; Mauel, M.E.; Maurer, D.; Nadle, D.; Taylor, E.; Xiao, Q.; Wurden, G.A.; Reass, W.A.

1997-01-01

Closed and open loop control techniques were applied to growing m/n=2/1 rotating islands in wall stabilized plasmas in the HBT-EP tokamak. The approach taken by HBT-EP combines an adjustable segmented conducting wall (which slows the growth or stabilizes ideal external kinks) with a number of small (6degree wide) saddle coils located between the gaps of the conducting wall. In this paper we report demonstration of 2-phase island rotation control from 5 kHz to 15 kHz and observation of the phase instability which are well modeled by the single-helicity, predictions of nonlinear Rutherford island dynamics for 2/1 tearing modes including important effects of ion inertia and FLR which appears as a damping term in the model equations. The closed loop response of active feedback control of the 2/1 mode at moderate gain was observed to be in good agreement with the theory. We have also demonstrated suppression of the 2/1 island growth using an asynchronous frequency modulation drive which maintains the flow damping of the island by application of rotating control fields with frequencies alternating above and below the natural mode frequency. This frequency modulation control technique was also able to prevent disruptions normally observed to follow giant sawtooth crashes in the plasma core

PrEP Whores and HIV Prevention: The Queer Communication of HIV Pre-Exposure Prophylaxis (PrEP).

Science.gov (United States)

Spieldenner, Andrew

2016-12-01

HIV pre-exposure prophylaxis (PrEP) has been introduced as another biomedical tool in HIV prevention. Whereas other such tools-including post-exposure prophylaxis (PEP) and interruption of perinatal transmission-have been embraced by those impacted by HIV, PrEP has been met with more conflict, especially within the gay community and HIV organizations. The "PrEP whore" has come to designate the social value and personal practices of those taking PrEP. This study examines the "PrEP whore" discourse by using queer theory and quare theory. Within these theoretical vantage points, the study explicates four discursive areas: slut shaming, dirty/clean binaries, mourning the loss of condoms, and reclaiming the inner whore. The study illuminates possible discursive strategies that lie outside of the domains of public health and within the individual and community.

Deep Borehole Field Test Requirements and Controlled Assumptions.

Energy Technology Data Exchange (ETDEWEB)

Hardin, Ernest [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-07-01

This document presents design requirements and controlled assumptions intended for use in the engineering development and testing of: 1) prototype packages for radioactive waste disposal in deep boreholes; 2) a waste package surface handling system; and 3) a subsurface system for emplacing and retrieving packages in deep boreholes. Engineering development and testing is being performed as part of the Deep Borehole Field Test (DBFT; SNL 2014a). This document presents parallel sets of requirements for a waste disposal system and for the DBFT, showing the close relationship. In addition to design, it will also inform planning for drilling, construction, and scientific characterization activities for the DBFT. The information presented here follows typical preparations for engineering design. It includes functional and operating requirements for handling and emplacement/retrieval equipment, waste package design and emplacement requirements, borehole construction requirements, sealing requirements, and performance criteria. Assumptions are included where they could impact engineering design. Design solutions are avoided in the requirements discussion. Deep Borehole Field Test Requirements and Controlled Assumptions July 21, 2015 iv ACKNOWLEDGEMENTS This set of requirements and assumptions has benefited greatly from reviews by Gordon Appel, Geoff Freeze, Kris Kuhlman, Bob MacKinnon, Steve Pye, David Sassani, Dave Sevougian, and Jiann Su.

Performance of MarSite Multi parameter Borehole Instrumentation

Science.gov (United States)

Guralp, Cansun; Tunc, Suleyman; Ozel, Oguz; Meral Ozel, Nurcan; Necmioglu, Ocal

2017-04-01

In this paper we present two year results obtained from the integrated multiparameter borehole system at Marsite. The very broad band (VBB) system have been operating since installation in November 2014; one year in a water filled borehole and one year in a dry Borehole. from January 2016. The real time data has been available to the community. The two Borehole environments are compared showing the superior performance of dry borehole environ- ment compared to water filled for a very broad band (VBB) seismometer. The practical considerations applied in both borehole installations are compared and the best borehole practical installation techniques are presented and discussed. The data is also compared with a surface 120 second broad band sensor and the seismic arrays with in MarSite region. The very long term performance, (one year data in a dry hole) of the VBB Borehole seismometer and the Dilatometer will be presented The high frequency performance of the VBB seismometer which extends to 150 Hz and the dilatometer are compared characterizing the results from the dilatometer.

Geomechanical Considerations for the Deep Borehole Field Test

Science.gov (United States)

Park, B. Y.

2015-12-01

Deep borehole disposal of high-level radioactive waste is under consideration as a potential alternative to shallower mined repositories. The disposal concept consists of drilling a borehole into crystalline basement rocks to a depth of 5 km, emplacement of canisters containing solid waste in the lower 2 km, and plugging and sealing the upper 3 km of the borehole. Crystalline rocks such as granites are particularly attractive for borehole emplacement because of their low permeability and porosity at depth, and high mechanical strength to resist borehole deformation. In addition, high overburden pressures contribute to sealing of some of the fractures that provide transport pathways. We present geomechanical considerations during construction (e.g., borehole breakouts, disturbed rock zone development, and creep closure), relevant to both the smaller-diameter characterization borehole (8.5") and the larger-diameter field test borehole (17"). Sandia National Laboratories is a multi-program laboratory managed and operated by Sandia Corporation, a wholly owned subsidiary of Lockheed Martin Corporation, for the U.S. Department of Energy's National Nuclear Security Administration under contract DE-AC04-94AL85000.

Borehole Seismology: Fundamentals and Applications

International Nuclear Information System (INIS)

Bohnhoff, Marco

2014-01-01

Because boring in itself is very expensive and instrumentation is required to endure high temperatures and pressures, deep borehole observation was accompanied by an economic risk. However, it has great advantages with respect to micro-earthquake observation, which is enriched with a short period vibration signal, because deep borehole observation greatly reduces short period noise. These kind advantages were explained by referring to the relationship between earthquake size and frequency range. Examples of seismic observation in a borehole in a geothermal field in El Salvador and a CO 2 confinement project in the western part of Canada were introduced. (authors)

Characterisation of the exopolysaccharide (EPS)-producing Lactobacillus paraplantarum BGCG11 and its non-EPS producing derivative strains as potential probiotics.

Science.gov (United States)

Nikolic, Milica; López, Patricia; Strahinic, Ivana; Suárez, Ana; Kojic, Milan; Fernández-García, María; Topisirovic, Ljubisa; Golic, Natasa; Ruas-Madiedo, Patricia

2012-08-17

Traditional fermented foods are the best source for the isolation of strains with specific traits to act as functional starters and to keep the biodiversity of the culture collections. Besides, these strains could be used in the formulation of foods claimed to promote health benefits, i.e. those containing probiotic microorganisms. For the rational selection of strains acting as probiotics, several in vitro tests have been proposed. In the current study, we have characterized the probiotic potential of the strain Lactobacillus paraplantarum BGCG11, isolated from a Serbian soft, white, homemade cheese, which is able to produce a "ropy" exopolysaccharide (EPS). Three novobiocin derivative strains, which have lost the ropy phenotype, were characterized as well in order to determine the putative role of the EPS in the probiotic potential. Under chemically gastrointestinal conditions, all strains were able to survive around 1-2% (10(6)-10(7)cfu/ml cultivable bacteria) only when they were included in a food matrix (1% skimmed milk). The strains were more resistant to acid conditions than to bile salts and gastric or pancreatic enzymes, which could be due to a pre-adaptation of the parental strain to acidic conditions in the cheese habitat. The ropy EPS did not improve the survival of the producing strain. On the contrary, the presence of an EPS layer surrounding the strain BGCG11 hindered its adhesion to the three epithelial intestinal cell lines tested, since the adhesion of the three non-ropy derivatives was higher than the parental one and also than that of the reference strain Lactobacillus rhamnosus GG. Aiming to propose a potential target application of these strains as probiotics, the cytokine production of peripheral blood mononuclear cells (PBMC) was analyzed. The EPS-producing L. paraplantarum BGCG11 strain showed an anti-inflammatory or immunosuppressor profile whereas the non-ropy derivative strains induced higher pro-inflammatory response. In addition, when

Borehole imaging tool detects well bore fractures

International Nuclear Information System (INIS)

Ma, T.A.; Bigelow, E.L.

1993-01-01

This paper reports on borehole imaging data which can provide high quality geological and petrophysical information to improve fracture identification, dip computations, and lithology determinations in a well bore. The ability to visually quantify the area of a borehole wall occupied by fractures and vugs enhances reservoir characterization and well completion operations. The circumferential borehole imaging log (CBIL) instrument is an acoustic logging device designed to produce a map of the entire borehole wall. The visual images can confirm computed dips and the geological features related to dip. Borehole geometry, including breakout, are accurately described by complete circumferential caliper measurements, which is important information for drilling and completion engineers. In may reservoirs, the images can identify porosity type, bedding characteristics, and petrophysical parameters

Borehole DC-6 hydrostratigraphic chart

International Nuclear Information System (INIS)

Gephart, R.E.

1981-09-01

This hydrostratigraphic chart for Borehole DC-6 identifies the basic stratigraphy and preliminary hydrologic test results. This borehole was cored for obtaining stratigraphic data and only that portion within the Grande Ronde formation remains open for hydrologic testing. The upper two formations were cased and cemented off

The Fessenheim nuclear power plant, at the service of a safe, competitive and CO2-free power generation in the heart of the Alsace region

International Nuclear Information System (INIS)

2010-01-01

In less than 20 years, Electricite de France (EDF) has built up a competitive park of 58 nuclear power plants, with no equivalent elsewhere, which represents an installed power of 63.1 GW (85% of EDF's power generation). Inside this nuclear park, the national power generation centre of Fessenheim comprises two production units of 900 MW each (1800 MW as a whole). The facility generated 8.7 billion kWh in 2009, i.e. 70% of the energy consumed in the Alsace region. This brochure presents the life of the power plant under various aspects: power generation, safety priority and culture, maintenance investments, respect of the environment, long-term fuel and wastes management, local economical involvement, transparency and public information, key figures and dates. (J.S.)

High-intensity laser diagnostics for OMEGA EP

Energy Technology Data Exchange (ETDEWEB)

Bromage, J.; Zuegel, J.D.; Bahk, S.W.; Vickery, D.S.; Waxer, L.J.; Irwin, D.; Bagnoud, V.; Boni, R.; Moore, M.D.; Jungquist, R.; Stoeckl, C. [Rochester Univ., Lab. for Laser Energetics, NY (United States)

2006-06-15

OMEGA EP (Extended Performance) is a new high-energy peta-watt laser system under construction at the University of Rochester's Laboratory for Laser Energetics. This paper describes our designs for two diagnostics critical to OMEGA EP's mission. The focal-spot diagnostic (FSD) is responsible for characterizing the focal spot of OMEGA EP's off-axis parabolic mirror at full energy. The ultrafast temporal diagnostic (UTD) is responsible for characterizing pulse shapes of full-energy target shots ranging in width from < 1 to 100 ps as well as setting the desired pulse width before the shot. These diagnostics will enable, for the first time, complete spatial and temporal characterization of the focus of a high-energy peta-watt laser at full energy. (authors)

High-intensity laser diagnostics for OMEGA EP

International Nuclear Information System (INIS)

Bromage, J.; Zuegel, J.D.; Bahk, S.W.; Vickery, D.S.; Waxer, L.J.; Irwin, D.; Bagnoud, V.; Boni, R.; Moore, M.D.; Jungquist, R.; Stoeckl, C.

2006-01-01

OMEGA EP (Extended Performance) is a new high-energy peta-watt laser system under construction at the University of Rochester's Laboratory for Laser Energetics. This paper describes our designs for two diagnostics critical to OMEGA EP's mission. The focal-spot diagnostic (FSD) is responsible for characterizing the focal spot of OMEGA EP's off-axis parabolic mirror at full energy. The ultrafast temporal diagnostic (UTD) is responsible for characterizing pulse shapes of full-energy target shots ranging in width from < 1 to 100 ps as well as setting the desired pulse width before the shot. These diagnostics will enable, for the first time, complete spatial and temporal characterization of the focus of a high-energy peta-watt laser at full energy. (authors)

Concentration of trace metals in boreholes in the Ankobra Basin, Ghan

African Journals Online (AJOL)

Roughly 25% of the boreholes had manganese concentration higher than 500 mg l-1, which is the WHO maximum acceptable limit for drinking water. The concentration of mercury was higher than 1.0 mg l-1 (WHO maximum acceptable limit) in 60% of the boreholes during the rainy season but below detection limit in the dry ...

Polarimetric borehole radar measurement near Nojima fault and its application to subsurface crack characterization; Polarimetric borehole radar ni yoru Nojima danso shuhen no chika kiretsu keisoku jikken

Energy Technology Data Exchange (ETDEWEB)

Sato, M.; Taniguchi, Y.; Miwa, T.; Niitsuma, H. [Tohoku University, Sendai (Japan); Ikeda, R. [National Research Institute for Disaster Prevention, Tsukuba (Japan); Makino, K. [Geophysical Surveying and Consulting Co. Ltd., Tokyo (Japan)

1997-05-27

Practical application of subsurface crack characterization by the borehole radar measurement to which the radar polarimetric method was introduced was attempted to measuring objects for which the borehole radar has not been much used, for example, the inside of low loss rock mass or fracture zone where cracks tightly exist. A system was trially manufactured which makes the radar polarimetric measurement possible in the borehole at a 1000m depth and with a about 10cm diameter, and a field experiment was conducted for realizing the subsurface crack characterization near the Nojima fault. For the measuring experiment by the polarimetric borehole radar, used were Iwaya borehole and Hirabayashi borehole drilled in the north of Awaji-shima, Hyogo-ken. In a comparison of both polarization systems of Hirabayashi borehole, reflected waves at depths of 1038m and 1047m are relatively stronger in both polarization systems than those with the same polarization form and at different depths, whereas reflected waves around a 1017m depth are strong only as to the parallel polarization system. Characteristics of the polarization in this experiment indirectly reflect crack structures. 6 refs., 6 figs., 1 tab.

Borehole Data

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Records of past temperature derived from boreholes drilled into the Earth crust. Parameter keywords describe what was measured in this data set. Additional summary...

Evaluation of geophysical borehole studies

International Nuclear Information System (INIS)

Brotzen, O.; Duran, O.; Magnusson, K.Aa.

Four studies concerning geophysical investigations and TV inspection in boreholes in connection with KBS studies at Finnsjoe, Karlshamn, Kraakemaala and Stripa and PRAV's studies at Studsvik have been evaluated. This has led to proposals concerning the choice of instruments and methods for future studies and a review of future work required. The evaluation has shown that the following borehole measurements are of primary interest in the continued work: Determinations of temperature and resistivity of the borehole liquid, resistance and resistivity measurements, SP, Sonic, Caliper and VLF. TV inspection, IP and gamma-gamma should also be included in the arsenal of available test methods.(author)

Borehole project - Final report of phase 3

International Nuclear Information System (INIS)

Pusch, R.; Ramqvist, G.

2008-03-01

The report describes borehole plugging techniques for use in deep boreholes extending from the ground surface, and construction and placement of plugs in holes of different lengths and orientations bored from the repository rooms. The principle employed is the one proposed in earlier phases of the project, i.e. to tightly seal those parts of boreholes where the rock has few fractures and a low hydraulic conductivity, and filling of those parts that intersect water-bearing fracture zones with physically stable material that does not need to be low-permeable. Four methods for tight plugging have been identified and tested and a technique has been found for filling boreholes that are intersected by fracture zones. The upper end of boreholes extending from the ground surface needs a 'mechanical' seal for which copper metal and concrete work well. The experience from plugging of a 550 m deep borehole at Olkiluoto (OL-KR24) has been compiled and plans worked out for sampling and testing of contacting clay and concrete in this hole and in short holes in the Aespoe URL. (orig.)

Borehole disposal design concept in Madagascar

International Nuclear Information System (INIS)

Randriamarolahy, J.N.; Randriantseheno, H.F.; Andriambololona, Raoelina

2008-01-01

Full text: In Madagascar, sealed radioactive sources are used in several socio-economic sectors such as medicine, industry, research and agriculture. At the end of their useful lives, these radioactive sources become ionizing radiations waste and can be still dangerous because they can cause harmful effects to the public and the environment. 'Borehole disposal design concept' is needed for sitting up a safe site for storage of radioactive waste, in particular, sealed radioactive sources. Borehole disposal is an option for long-term management of small quantities of radioactive waste in compliance with the internationally accepted principles for radioactive waste management. Several technical aspects must be respected to carry out such a site like the geological, geomorphologic, hydrogeology, geochemical, meteorological and demographic conditions. Two sites are most acceptable in Madagascar such as Ankazobe and Fanjakana. A Borehole will be drilled and constructed using standard techniques developed for water abstraction, oil exploration. At the Borehole, the sealed radioactive sources are encapsulated. The capsule is inserted in a container. This type of storage is benefit for the developing countries because it is technologically simple and economic. The construction cost depends on the volume of waste to store and the Borehole depth. The borehole disposal concept provides a good level of safety to avoid human intrusion. The future protection of the generations against the propagation of the ionizing radiations is then assured. (author)

Acoustic and Optical Televiewer Borehole Logging

International Nuclear Information System (INIS)

Ahmad Hasnulhadi Che Kamaruddin; Nik Marzukee Nik Ibrahim; Zaidi Ibrahim; Nurul Wahida Ahmad Khairuddin; Azmi Ibrahim

2016-01-01

This review paper is focused on Borehole Televiewer. Borehole Televiewer or (BHTV) was used to obtain high-resolution acoustical images from the borehole wall. A probe with a high resolution downward looking camera is used. The camera has specific optics (a conical mirror with a ring of bulbs) with just one shot needed to capture the entire borehole circumference as a 360 panoramic view. Settings similar to traditional cameras (exposure, quality, light, frame rate and resolution) make it effective in almost any type of borehole fluid. After each shot, a series of horizontal pixel strings are acquired, giving a rasterized RGB picture in real-time which is transmitted to the console and finally to a monitor. The orientation device embedded in the tool, which is made of 3 inclinometers and 3 magnetometers, allows the inclination and azimuth of the probe to be computed in real-time, correctly orienting the borehole images. Besides, Acoustic and Optical Televiewer has been introduced as its advanced in technological research. Its logging has been successfully applied to geotechnical investigations and mineral exploration (Schepers et al., 2001) due to advances in beam focusing, increased dynamic range, digital recording techniques, and digital data processing (Schepers, 1991). Thus, this paper will go through to the basic principle of (BHTV) as one type of data collection today. (author)

Characterization of Cell Surface and EPS Remodeling of Azospirillum brasilense Chemotaxis-like 1 Signal Transduction Pathway mutants by Atomic Force Microscopy

Energy Technology Data Exchange (ETDEWEB)

Billings, Amanda N [ORNL; Siuti, Piro [ORNL; Bible, Amber [University of Tennessee, Knoxville (UTK); Alexandre, Gladys [University of Tennessee, Knoxville (UTK); Retterer, Scott T [ORNL; Doktycz, Mitchel John [ORNL; Morrell-Falvey, Jennifer L [ORNL

2011-01-01

To compete in complex microbial communities, bacteria must quickly sense environmental changes and adjust cellular functions for optimal growth. Chemotaxis-like signal transduction pathways are implicated in the modulation of multiple cellular responses, including motility, EPS production, and cell-to-cell interactions. Recently, the Che1 chemotaxis-like pathway from Azospirillum brasilense was shown to modulate flocculation. In A. brasilense, cell surface properties, including EPS production, are thought to play a direct role in promoting flocculation. Using atomic force microscopy (AFM), we have detected distinct changes in the surface morphology of flocculating A. brasilense Che1 mutant strains that are absent in the wild type strain. Whereas the wild type strain produces a smooth mucosal extracellular matrix, the flocculating Che1 mutant strains produce distinctive extracellular fibril structures. Further analyses using flocculation inhibition and lectin-binding assays suggest that the composition of EPS components in the extracellular matrix differs between the cheA1 and cheY1 mutants, despite an apparent similarity in the macroscopic floc structures. Collectively, these data indicate that mutations in the Che1 pathway that result in increased flocculation are correlated with distinctive changes in the extracellular matrix structure produced by the mutants, including likely changes in the EPS structure and/or composition.

Thermal modelling of borehole heat exchangers and borehole thermal energy stores; Zur thermischen Modellierung von Erdwaermesonden und Erdsonden-Waermespeichern

Energy Technology Data Exchange (ETDEWEB)

Bauer, Dan

2011-07-15

The thermal use of the underground for heating and cooling applications can be done with borehole heat exchangers. This work deals with the further development of the modelling of thermal transport processes inside and outside the borehole as well as with the application of the further developed models. The combination of high accuracy and short computation time is achieved by the development of three-dimensional thermal resistance and capacity models for borehole heat exchangers. Short transient transport processes can be calculated by the developed model with a considerable higher dynamic and accuracy than with known models from literature. The model is used to evaluate measurement data of a thermal response test by parameter estimation technique with a transient three-dimensional model for the first time. Clear advantages like shortening of the test duration are shown. The developed borehole heat exchanger model is combined with a three-dimensional description of the underground in the Finite-Element-Program FEFLOW. The influence of moving groundwater on borehole heat exchangers and borehole thermal energy stores is then quantified.

Deep borehole disposal of high-level radioactive waste.

Energy Technology Data Exchange (ETDEWEB)

Stein, Joshua S.; Freeze, Geoffrey A.; Brady, Patrick Vane; Swift, Peter N.; Rechard, Robert Paul; Arnold, Bill Walter; Kanney, Joseph F.; Bauer, Stephen J.

2009-07-01

Preliminary evaluation of deep borehole disposal of high-level radioactive waste and spent nuclear fuel indicates the potential for excellent long-term safety performance at costs competitive with mined repositories. Significant fluid flow through basement rock is prevented, in part, by low permeabilities, poorly connected transport pathways, and overburden self-sealing. Deep fluids also resist vertical movement because they are density stratified. Thermal hydrologic calculations estimate the thermal pulse from emplaced waste to be small (less than 20 C at 10 meters from the borehole, for less than a few hundred years), and to result in maximum total vertical fluid movement of {approx}100 m. Reducing conditions will sharply limit solubilities of most dose-critical radionuclides at depth, and high ionic strengths of deep fluids will prevent colloidal transport. For the bounding analysis of this report, waste is envisioned to be emplaced as fuel assemblies stacked inside drill casing that are lowered, and emplaced using off-the-shelf oilfield and geothermal drilling techniques, into the lower 1-2 km portion of a vertical borehole {approx}45 cm in diameter and 3-5 km deep, followed by borehole sealing. Deep borehole disposal of radioactive waste in the United States would require modifications to the Nuclear Waste Policy Act and to applicable regulatory standards for long-term performance set by the US Environmental Protection Agency (40 CFR part 191) and US Nuclear Regulatory Commission (10 CFR part 60). The performance analysis described here is based on the assumption that long-term standards for deep borehole disposal would be identical in the key regards to those prescribed for existing repositories (40 CFR part 197 and 10 CFR part 63).

Research borehole drilling activity for boreholes DH-18, DH-19, DC-12, DC-13, DC-14, DC-15, and deepening of existing borehole DC-7

International Nuclear Information System (INIS)

1979-09-01

This report is an environmental evaluation of the impacts of proposed borehole drilling activities at the Hanford Site, northwest of Richland, Washington. The proposed action is to drill six research boreholes ranging in depth from 137 to 1372 meters (m) [250 to 4500 +- feet (ft)]. In addition, an existing borehole (DC-7) will be extended from 1249 to 1524 m (4099 to 5000 +- ft). The purpose of the US Department of Energy's (DOE) borehole drilling activities is to collect data on in situ rock formations that are considered potentialy suitable for nuclear waste repositories. The technical program efforts necessary to identify and qualify specific underground waste facility sites in candidate rock formations include geologic and hydrologic studies (seismicity and tectonics, rock structure and stratigraphy, lithology, etc.). Borehole drilling is an integral part of the geological studies and is essential to a thorough understanding of potentially suitable geologic formations. The purpose of the proposed drilling activities is to obtain data for evaluating Columbia River basalts that are being evaluated by the National Waste Terminal Storage (NWTS) Program to determine their suitability potential for nuclear waste repositories. Unavoidable impact to the environment is limited primarily to the clearing of land needed for access and drilling operations. Considerations exercised during site preparation, drilling, and subsequent site restoration will limit modification of the natural environment to the minimum required for accomplishment of test objectives

Fosforihapon epäpuhtauksien uuttaminen

OpenAIRE

Sengström, Heli

2012-01-01

Fosforihappoa tuotetaan yleisesti sekä märkäprosessilla että termisellä prosessilla. Märkäprosessilla tuotettuun fosforihappoon jää erilaisia epäpuhtauksia, joita ei happoa käytettäessä saisi olla. Yleisimmät epäpuhtaudet ovat erilaiset fluoridit, kloridit ja metallit. Tämän opinnäytetyön tavoitteena oli selvittää, kuinka hyvin nämä epäpuhtaudet saadaan poistettua uuttamalla happoa liuottimella, jossa on 80 % tributyylifosfaattia (TBP) ja 20 % ExxsolTM D80 -laimenninta. Työn kokeellisessa ...

EpCAM-Independent Enrichment of Circulating Tumor Cells in Metastatic Breast Cancer

Science.gov (United States)

Schneck, Helen; Gierke, Berthold; Uppenkamp, Frauke; Behrens, Bianca; Niederacher, Dieter; Stoecklein, Nikolas H.; Templin, Markus F.; Pawlak, Michael; Fehm, Tanja; Neubauer, Hans

2015-01-01

Circulating tumor cells (CTCs) are the potential precursors of metastatic disease. Most assays established for the enumeration of CTCs so far–including the gold standard CellSearch—rely on the expression of the cell surface marker epithelial cell adhesion molecule (EpCAM). But, these approaches may not detect CTCs that express no/low levels of EpCAM, e.g. by undergoing epithelial-to-mesenchymal transition (EMT). Here we present an enrichment strategy combining different antibodies specific for surface proteins and extracellular matrix (ECM) components to capture an EpCAMlow/neg cell line and EpCAMneg CTCs from blood samples of breast cancer patients depleted for EpCAM-positive cells. The expression of respective proteins (Trop2, CD49f, c-Met, CK8, CD44, ADAM8, CD146, TEM8, CD47) was verified by immunofluorescence on EpCAMpos (e.g. MCF7, SKBR3) and EpCAMlow/neg (MDA-MB-231) breast cancer cell lines. To test antibodies and ECM proteins (e.g. hyaluronic acid (HA), collagen I, laminin) for capturing EpCAMneg cells, the capture molecules were first spotted in a single- and multi-array format onto aldehyde-coated glass slides. Tumor cell adhesion of EpCAMpos/neg cell lines was then determined and visualized by Coomassie/MitoTracker staining. In consequence, marginal binding of EpCAMlow/neg MDA-MB-231 cells to EpCAM-antibodies could be observed. However, efficient adhesion/capturing of EpCAMlow/neg cells could be achieved via HA and immobilized antibodies against CD49f and Trop2. Optimal capture conditions were then applied to immunomagnetic beads to detect EpCAMneg CTCs from clinical samples. Captured CTCs were verified/quantified by immunofluorescence staining for anti-pan-Cytokeratin (CK)-FITC/anti-CD45 AF647/DAPI. In total, in 20 out of 29 EpCAM-depleted fractions (69%) from 25 metastatic breast cancer patients additional EpCAMneg CTCs could be identified [range of 1–24 CTCs per sample] applying Trop2, CD49f, c-Met, CK8 and/or HA magnetic enrichment. Ep

A strategy to seal exploratory boreholes in unsaturated tuff

International Nuclear Information System (INIS)

Fernandez, J.A.; Case, J.B.; Givens, C.A.; Carney, B.C.

1994-04-01

This report presents a strategy for sealing exploratory boreholes associated with the Yucca Mountain Site Characterization Project. Over 500 existing and proposed boreholes have been considered in the development of this strategy, ranging from shallow (penetrating into alluvium only) to deep (penetrating into the groundwater table). Among the comprehensive list of recommendations are the following: Those boreholes within the potential repository boundary and penetrating through the potential repository horizon are the most significant boreholes from a performance standpoint and should be sealed. Shallow boreholes are comparatively insignificant and require only nominal sealing. The primary areas in which to place seals are away from high-temperature zones at a distance from the potential repository horizon in the Paintbrush nonwelded tuff and the upper portion of the Topopah Spring Member and in the tuffaceous beds of the Calico Hills Unit. Seals should be placed prior to waste emplacement. Performance goals for borehole seals both above and below the potential repository are proposed. Detailed construction information on the boreholes that could be used for future design specifications is provided along with a description of the environmental setting, i.e., the geology, hydrology, and the in situ and thermal stress states. A borehole classification scheme based on the condition of the borehole wall in different tuffaceous units is also proposed. In addition, calculations are presented to assess the significance of the boreholes acting as preferential pathways for the release of radionuclides. Design calculations are presented to answer the concerns of when, where, and how to seal. As part of the strategy development, available technologies to seal exploratory boreholes (including casing removal, borehole wall reconditioning, and seal emplacement) are reviewed

Single-borehole techniques

International Nuclear Information System (INIS)

Klotz, D.; Moser, H.; Trimborn, P.

1978-01-01

Proceeding on the theoretical considerations and on the experience and practice derived from laboratory and field testing, a system consisting of tracer injection units, detector units, measuring probe units and packers is presented, from which the different borehole probes required can be combined. A couple of examples of recent applications shows the position of the Single-Borehole Techniques with respect to the traditional methods used for the measurement of the ground-water flow. A confrontation of the permeabilities of different aquifers consents, both on the basis of the Single-Borehole Techniques as by pumping experiments, the determination of the reliability of the Point-Dilution-Method. The Point-Dilution-Method is giving information about the vertical and horizontal distribution of the permeabilities in an aquifer. By measuring the vertical current in two karst wells, the tributary horizons of a well have been determined, which gave valuable information for the subsequent well construction. Local leakages could be detected by measuring the vertical flow rate through observation wells arranged along a grout curtain erected on both sides of the retaining barrage of the Keban dam. (orig.) [de

Borehole stability in densely welded tuffs

International Nuclear Information System (INIS)

Fuenkajorn, K.; Daemen, J.J.K.

1992-07-01

The stability of boreholes, or more generally of underground openings (i.e. including shafts, ramps, drifts, tunnels, etc.) at locations where seals or plugs are to be placed is an important consideration in seal design for a repository (Juhlin and Sandstedt, 1989). Borehole instability or borehole breakouts induced by stress redistribution could negate the effectiveness of seals or plugs. Breakout fractures along the wall of repository excavations or exploratory holes could provide a preferential flowpath for groundwater or gaseous radionuclides to bypass the plugs. After plug installation, swelling pressures exerted by a plug could induce radial cracks or could open or widen preexisting cracks in the rock at the bottom of the breakouts where the tangential compressive stresses have been released by the breakout process. The purpose of the work reported here is to determine experimentally the stability of a circular hole in a welded tuff sample subjected to various external boundary loads. Triaxial and biaxial borehole stability tests have been performed on densely welded Apache Leap tuff samples and Topopah Spring tuff samples. The nominal diameter of the test hole is 13.3 or 14.4 mm for triaxial testing, and 25.4 mm for biaxial testing. The borehole axis is parallel to one of the principal stress axes. The boreholes are drilled through the samples prior to applying external boundary loads. The boundary loads are progressively increased until breakouts occur or until the maximum load capacity of the loading system has been reached. 74 refs

Excess plutonium disposition: The deep borehole option

International Nuclear Information System (INIS)

Ferguson, K.L.

1994-01-01

This report reviews the current status of technologies required for the disposition of plutonium in Very Deep Holes (VDH). It is in response to a recent National Academy of Sciences (NAS) report which addressed the management of excess weapons plutonium and recommended three approaches to the ultimate disposition of excess plutonium: (1) fabrication and use as a fuel in existing or modified reactors in a once-through cycle, (2) vitrification with high-level radioactive waste for repository disposition, (3) burial in deep boreholes. As indicated in the NAS report, substantial effort would be required to address the broad range of issues related to deep bore-hole emplacement. Subjects reviewed in this report include geology and hydrology, design and engineering, safety and licensing, policy decisions that can impact the viability of the concept, and applicable international programs. Key technical areas that would require attention should decisions be made to further develop the borehole emplacement option are identified

Experiments on stress dependent borehole acoustic waves.

Science.gov (United States)

Hsu, Chaur-Jian; Kane, Michael R; Winkler, Kenneth; Wang, Canyun; Johnson, David Linton

2011-10-01

In the laboratory setup, a borehole traverses a dry sandstone formation, which is subjected to a controlled uniaxial stress in the direction perpendicular to the borehole axis. Measurements are made in a single loading-unloading stress cycle from zero to 10 MPa and then back down to zero stress. The applied stress and the presence of the borehole induce anisotropy in the bulk of the material and stress concentration around the borehole, both azimuthally and radially. Acoustic waves are generated and detected in the water-filled borehole, including compressional and shear headwaves, as well as modes of monopole, dipole, quadrupole, and higher order azimuthal symmetries. The linear and non-linear elastic parameters of the formation material are independently quantified, and utilized in conjunction with elastic theories to predict the characteristics of various borehole waves at zero and finite stress conditions. For example, an analytic theory is developed which is successfully used to estimate the changes of monopole tube mode at low frequency resulted from uniaxial stress, utilizing the measured material third order elasticity parameters. Comparisons between various measurements as well as that between experiments and theories are also presented. © 2011 Acoustical Society of America

Geology of the Waste Treatment Plant Seismic Boreholes

Energy Technology Data Exchange (ETDEWEB)

Barnett, D. Brent; Fecht, Karl R.; Reidel, Stephen P.; Bjornstad, Bruce N.; Lanigan, David C.; Rust, Colleen F.

2007-05-11

In 2006, the U.S. Department of Energy initiated the Seismic Boreholes Project (SBP) to emplace boreholes at the Waste Treatment Plant (WTP) site in order to obtain direct shear wave velocity (Vs) measurements and other physical property measurements in Columbia River basalt and interbedded sediments of the Ellensburg Formation. The goal was to reduce the uncertainty in the response spectra and seismic design basis, and potentially recover design margin for the WTP. The characterization effort within the deep boreholes included 1) downhole measurements of the velocity properties of the suprabasalt, basalt, and sedimentary interbed sequences, 2) downhole measurements of the density of the subsurface basalt and sediments, and 3) geologic studies to confirm the geometry of the contact between the various basalt and interbedded sediments through examination of retrieved core from the core hole and data collected through geophysical logging of each borehole. This report describes the results of the geologic studies from three mud-rotary boreholes and one cored borehole at the WTP. All four boreholes penetrated the entire Saddle Mountains Basalt and the upper part of the Wanapum Basalt where thick sedimentary interbeds occur between the lava flows. The basalt flows penetrated in Saddle Mountains Basalt included the Umatilla Member, Esquatzel Member, Pomona Member, and the Elephant Mountain Member. The underlying Priest Rapids Member of the Wanapum Basalt also was penetrated. The Ellensburg Formation sediments consist of the Mabton Interbed, the Cold Creek Interbed, the Selah Interbed, and the Rattlesnake Ridge Interbed; the Byron Interbed occurs between two flows of the Priest Rapids Member. The Mabton Interbed marks the contact between the Wanapum and Saddle Mountains Basalts. The thicknesses of the basalts and interbedded sediments were within expected limits. However, a small reverse fault was found in the Pomona Member flow top. This fault has three periods of

Geology of the Waste Treatment Plant Seismic Boreholes

Energy Technology Data Exchange (ETDEWEB)

Barnett, D. BRENT; Bjornstad, Bruce N.; Fecht, Karl R.; Lanigan, David C.; Reidel, Steve; Rust, Colleen F.

2007-02-28

In 2006, DOE-ORP initiated the Seismic Boreholes Project (SBP) to emplace boreholes at the Waste Treatment Plant (WTP) site in order to obtain direct Vs measurements and other physical property measurements in Columbia River basalt and interbedded sediments of the Ellensburg Formation. The goal was to reduce the uncertainty in the response spectra and seismic design basis, and potentially recover design margin for the WTP. The characterization effort within the deep boreholes included 1) downhole measurements of the velocity properties of the suprabasalt, basalt, and sedimentary interbed sequences, 2) downhole measurements of the density of the subsurface basalt and sediments, and 3) confirmation of the geometry of the contact between the various basalt and interbedded sediments through examination of retrieved core from the corehole and data collected through geophysical logging of each borehole. This report describes the results of the geologic studies from three mud-rotary boreholes and one cored borehole at the WTP. All four boreholes penetrated the entire Saddle Mountains Basalt and the upper part of the Wanapum Basalt where thick sedimentary interbeds occur between the lava flows. The basalt flows penetrated in Saddle Mountains Basalt included the Umatilla Member, Esquatzel Member, Pomona Member and the Elephant Mountain Member. The underlying Priest Rapids Member of the Wanapum Basalt was also penetrated. The Ellensburg Formation sediments consist of the Mabton Interbed, the Cold Creek Interbed, the Selah Interbed and the Rattlesnake Ridge Interbed; the Byron Interbed occurs between two flows of the Priest Rapids Member. The Mabton Interbed marks the contact between the Wanapum and Saddle Mountains Basalts. The thicknesses of the basalts and interbedded sediments were within expected limits. However, a small reverse fault was found in the Pomona Member flow top. This fault has three periods of movement and less than 15 feet of repeated section. Most of the

Multi-year monitoring of radon in boreholes at the Modra geophysical observatory, Slovakia

International Nuclear Information System (INIS)

Smetanova, I.; Steinitz, G.; Holy, K.

2017-01-01

Long-term radon monitoring was performed in two boreholes, at a depth of 13 m in the 40 m deep V-2 borehole (August 2003 September 2005), and at 3 m depth in the 10 m deep V-3 borehole (August 2003 April 2008). Diurnal, multi-day and annual variations in radon time-series were observed. Daily average of radon activity in V-2 borehole was significantly higher and ranged from 6.5 to 383.7 kBq/m 3 , while in V-3 borehole only between 1.2 and 139.4 kBq/m 3 . The seasonal pattern was more pronounced in V-3 time series, with the maximum occurring from October to March. Multi-day variations (2-10 days) were registered in V-2 and V-3 mostly simultaneously, with higher discrepancy in spring and summer periods, when radon activity in V-3 borehole was low. Diurnal radon variations with two maxima and two minima per day were registered in both boreholes. The influence of meteorological parameters on radon concentrations was investigated. The overall impression is that seasonal variation in radon in V-3 borehole seems to be connected with the temperature variation. Multi-day variations of radon in both boreholes coincided with the atmospheric pressure changes. An increase in radon activity was observed in V-3 borehole after the rainfall in spring and summer seasons. (authors)

Structural features of subtype-selective EP receptor modulators.

Science.gov (United States)

Markovič, Tijana; Jakopin, Žiga; Dolenc, Marija Sollner; Mlinarič-Raščan, Irena

2017-01-01

Prostaglandin E2 is a potent endogenous molecule that binds to four different G-protein-coupled receptors: EP1-4. Each of these receptors is a valuable drug target, with distinct tissue localisation and signalling pathways. We review the structural features of EP modulators required for subtype-selective activity, as well as the structural requirements for improved pharmacokinetic parameters. Novel EP receptor subtype selective agonists and antagonists appear to be valuable drug candidates in the therapy of many pathophysiological states, including ulcerative colitis, glaucoma, bone healing, B cell lymphoma, neurological diseases, among others, which have been studied in vitro, in vivo and in early phase clinical trials. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

Selective inhibition of prostaglandin E2 receptors EP2 and EP4 induces apoptosis of human endometriotic cells through suppression of ERK1/2, AKT, NFkappaB, and beta-catenin pathways and activation of intrinsic apoptotic mechanisms.

Science.gov (United States)

Banu, Sakhila K; Lee, JeHoon; Speights, V O; Starzinski-Powitz, Anna; Arosh, Joe A

2009-08-01

Endometriosis is a benign chronic gynecological disease of reproductive-age women characterized by the presence of functional endometrial tissues outside the uterine cavity. It is an estrogen-dependent disease. Current treatment modalities to inhibit biosynthesis and actions of estrogen compromise menstruation, pregnancy, and the reproductive health of women and fail to prevent reoccurrence of disease. There is a critical need to identify new specific signaling modules for non-estrogen-targeted therapies for endometriosis. In our previous study, we reported that selective inhibition of cyclooxygenase-2 prevented survival, migration, and invasion of human endometriotic epithelial and stromal cells, which was due to decreased prostaglandin E(2) (PGE(2)) production. In this study, we determined mechanisms through which PGE(2) promoted survival of human endometriotic cells. Results of the present study indicate that 1) PGE(2) promotes survival of human endometriotic cells through EP2 and EP4 receptors by activating ERK1/2, AKT, nuclear factor-kappaB, and beta-catenin signaling pathways; 2) selective inhibition of EP2 and EP4 suppresses these cell survival pathways and augments interactions between proapoptotic proteins (Bax and Bad) and antiapoptotic proteins (Bcl-2/Bcl-XL), facilitates the release of cytochrome c, and thus activates caspase-3/poly (ADP-ribose) polymerase-mediated intrinsic apoptotic pathways; and 3) these PGE(2) signaling components are more abundantly expressed in ectopic endometriosis tissues compared with eutopic endometrial tissues during the menstrual cycle in women. These novel findings may provide an important molecular framework for further evaluation of selective inhibition of EP2 and EP4 as potential therapy, including nonestrogen target, to expand the spectrum of currently available treatment options for endometriosis in women.

The assessment of the geophysical investigations of boreholes

International Nuclear Information System (INIS)

Brotzen, O.; Duran, O.; Magnusson, K.-Aa.

1980-02-01

Four geophysical investigations and a televiewer inspection of boreholes have been evaluated in connection with the examinations at Finnsjoen, Karlshamn, Kraakemaala, Stripa and Studsvik. A cooperative assessment of the systems for the measurement of boreholes by Lawrence Berkeley Laboratories and the Geological Survey of Sweden has been made at Stripa. The following methods should be selected for future measurements: determination of the resistivity and temperature of the fluid in the borehole, determination of the resistivity and temperature of the fluid in the borehole, determination of the self-potential, resistivity and resistance of the rock as well as the measurement of sonar waves, the diameter of the borehole and the very low frequency effects. (G.B.)

A Precision Measurement of the Inclusive ep Scattering Cross Section at HERA

CERN Document Server

Aaron, F.D.; Alimujiang, K.; Andreev, V.; Antunovic, B.; Asmone, A.; Backovic, S.; Baghdasaryan, A.; Barrelet, E.; Bartel, W.; Begzsuren, K.; Belousov, A.; Bizot, J.C.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J.G.; Coughlan, J.A.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Daum, K.; Deak, M.; de Boer, Y.; Delcourt, B.; Del Degan, M.; Delvax, J.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eliseev, A.; Elsen, E.; Falkiewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Fischer, D.-J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, Samvel; Glazov, A.; Glushkov, I.; Goerlich, L.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Grell, B.R.; Grindhammer, G.; Habib, S.; Haidt, D.; Helebrant, C.; Henderson, R.C.W.; Hennekemper, E.; Henschel, H.; Herbst, M.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hreus, T.; Jacquet, M.; Janssen, M.E.; Janssen, X.; Jemanov, V.; Jonsson, L.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I.R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Kluge, T.; Knutsson, A.; Kogler, R.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kutak, K.; Landon, M.P.J.; Lange, W.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Li, G.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martyn, H.-U.; Maxfield, S.J.; Mehta, A.; Meyer, A.B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Mudrinic, M.; Muller, K.; Murin, P.; Naroska, B.; Naumann, Th.; Newman, P.R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G.D.; Pejchal, O.; Perez, E.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Placakyte, R.; Pokorny, B.; Polifka, R.; Povh, B.; Preda, T.; Radescu, V.; Rahmat, A.J.; Raicevic, N.; Raspiareza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Ruiz Tabasco, J.E.; Rurikova, Z.; Rusakov, S.; Salek, D.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Shushkevich, S.; Sloan, T.; Smiljanic, Ivan; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, Arnd E.; Staykova, Z.; Steder, M.; Stella, B.; Stoicea, G.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P.D.; Toll, T.; Tomasz, F.; Tran, T.H.; Traynor, D.; Trinh, T.N.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Turnau, J.; Urban, K.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; von den Driesch, M.; Wegener, D.; Wallny, R.; Wissing, Ch.; Wunsch, E.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhokin, A.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.; Zus, R.

2009-01-01

A measurement of the inclusive deep-inelastic neutral current e+p scattering cross section is reported in the region of four-momentum transfer squared, 12<=Q^2<=150 GeV^2, and Bjorken x, 2x10^-4<=x<=0.1. The results are based on data collected by the H1 Collaboration at the ep collider HERA at positron and proton beam energies of E_e=27.6 GeV and E_p=920 GeV, respectively. The data are combined with previously published data, taken at E_p=820 GeV. The accuracy of the combined measurement is typically in the range of 1.3-2%. A QCD analysis at next-to-leading order is performed to determine the parton distributions in the proton based on H1 data.

Geological data summary for a borehole drilled between 1991 September 16 and 1991 October 1 for the Transport Properties in Highly Fractured Rock Experiment at the Underground Research Laboratory

Energy Technology Data Exchange (ETDEWEB)

Woodcock, D. R.; Everitt, R. A.

1992-08-01

Borehole 101-013-HG4 was drilled between 1991 September 16 and October 1 from the 130 Level station, as part of the Transport Properties in Highly Fractured Rock Experiment, to explore the geological, hydrogeological and geochemical conditions of the rock mass in an area northwest of the Underground Research Laboratory (URL) shaft. The borehole was drilled to provide information at an intersection with Fracture Zone 2.0, 100 m to the west of boreholes collared from Room 211 of the 240 Level for future solute transport experiments within Fracture Zone 2.0, and to further our understanding of the rock mass in the area. Fracture Zones 2.5, 2.0, 1.9 and a subvertical joint zone in the footwall were all intersected in the borehole. Preliminary results from detailed core logging show that the lithostructural domains intersected in the borehole correlate with those previously identified in the URL shaft, and in nearby exploration boreholes drilled from the 130 Level. The domains are shallow-dipping toward the southeast and are parallel to the three main fracture zones intersected in the borehole.

Borehole disposal design concept

International Nuclear Information System (INIS)

RANDRIAMAROLAHY, J.N.

2007-01-01

In Madagascar, the sealed radioactive sources are used in several socioeconomic sectors such as medicine, industry, research and agriculture. At the end of their useful lives, these radioactive sources become radioactive waste and can be still dangerous because they can cause harmful effects to the public and the environment. This work entitled 'Borehole disposal design concept' consists in putting in place a site of sure storage of the radioactive waste, in particular, sealed radioactive sources. Several technical aspects must be respected to carry out such a site like the geological, geomorphologic, hydrogeologic, geochemical, meteorological and demographic conditions. This type of storage is favorable for the developing countries because it is technologically simple and economic. The cost of construction depends on the volume of waste to store and the depth of the Borehole. The Borehole disposal concept provides a good level of safety to avoid the human intrusion. The future protection of the generations against the propagation of the radiations ionizing is then assured. [fr

Ion beam analysis and AMS dating of the silver coin hoard of Preuschdorf (Alsace, France)

Science.gov (United States)

Beck, Lucile; Alloin, Elise; Vigneron, Anaïs; Caffy, Ingrid; Klein, Ulrich

2017-09-01

The hoard of Preuschdorf is a monetary deposit discovered in Alsace (France) in 2005. This find was composed of 7327 silver-copper coins. They seem to have been struck over more than one century, between the end of the 15th and the beginning of the 17th century. This hoard is an exceptional find composed of a large quantity of coins from various periods, areas and contexts. It is also remarkable by the presence of counterfeit coins. IBA was used to analyze the silver content of the official coins by combining PIXE and RBS. The fineness was found to be between 20 and 42% according to the mint place and an unexpected subdivision of the values has been revealed. For the counterfeit coins, the analyses were able to bring to light different elaboration processes: amalgam silvering with two various contents of mercury and application of a thin layer of pure silver. Finally, linen fibers attached to the coins have been dated by AMS radiocarbon dating. The radiocarbon calibrated dates perfectly match with the chronological range given by the coins.

Elastic waves along a cylindrical borehole in a poroelastic medium ...

Indian Academy of Sciences (India)

In the oil industry, acoustic borehole logging is commonly practiced. A borehole is drilled in a potential hydro-carbon reservoir and then probed with an acoustic ...... The non-dimensional phase velocity c/Vmin, Vmin = min(V1,V2,V3,V4) is computed at different values of non-dimensional wavenumber ka varying from 0 to 85.

ep possibility for ISABELLE

International Nuclear Information System (INIS)

Wilson, R.

1977-01-01

The feasibility of adding an electron ring to ISABELLE is discussed in terms of cost, physics goals, count rate estimates, the detector requirements, and the possibility of producing intermediate bosons. The purpose of adding an electron ring to ISABELLE must be considered to be the study of e + p → e + x, e - p → νx, and e + p → anti νx. Other processes, such as W production, are less interesting for an ep ring than for a pp ring. However, there may be other new particles--such as leptonic quarks--that only turn up here. These processes are, however, exciting. In a 30 day run at L = 10 32 cm -2 sec -1 300 neutrino events are expected at q 2 > 5000 GeV 2 where the propagator is expected to be less than 1 / 4 . Thus the value of the mass in the propagator can be measured to 5%. The ep cross section would be measured over the momentum transfer range 1 2 2 ). This range is large enough that a logarithmic deviation from scaling can be distinguished easily from a power law approach to scaling

Geophysical borehole logging, dummy-sonding and optical imaging of the borehole OL-KR24 at Olkiluoto 2005

International Nuclear Information System (INIS)

Majapuro, J.

2006-03-01

Suomen Malmi Oy conducted geophysical borehole logging, dummy-sonding and optical imaging surveys of the borehole OL-KR24 at the Olkiluoto site in Eurajoki during 1.10.2005 - 4.10.2005. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The methods applied are caliper survey and optical imaging. The assignment included the field work of surveys, interpretation and processing of the data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Application of borehole radar to South Africa’s Ultra-Deep gold mining environment

CSIR Research Space (South Africa)

Trickett, JC

2000-05-01

Full Text Available ), the collar of which is located at a depth of 3.3 km below datum1. LIB boreholes are used to probe totally undeveloped blocks of ground and, being semi-parallel to reef, are ideal for the application of Borehole Radar. By applying Borehole Radar from... the target reef; viz. 1 For the Witwatersrand Basin Gold Mines, the datum is ? 1829 m above sea level. Ventersdorp Contact Reef (VCR), twice. It was drilled at 45? downwards into the hangingwall...

Purification and properties of extracellular polysaccharide (EPS) antigens produced by different mould species.

Science.gov (United States)

Notermans, S; Wieten, G; Engel, H W; Rombouts, F M; Hoogerhout, P; van Boom, J H

1987-02-01

Extracellular polysaccharide (EPS) antigens produced by different mould species were purified and partially characterized. Purification included (NH4)2SO4 treatment, Sepharose CL-4B column chromatography and Con A-sepharose chromatography. The EPS of Penicillium digitatum, Mucor racemosus and Cladosporium cladosporioides showed high antigenic capacities. Immunologically the EPS were partially genus-specific, but cross-reactivity was observed. The EPS antigens produced by species of Penicillium, Aspergillus repens and Geotrichum candidum lost their immunological activity upon heating (100 degrees C) at pH 1.8, while the EPS antigen of M. racemosus, Rhizopus oligosporus and C. cladosporioides were stable under the same conditions. The dominant monosaccharides present in the EPS antigen were mannose, galactose and glucose. The EPS obtained from cultures of M. racemosus and R. oligosporus also contained rhamnose. In the EPS produced by Penicillium spp. and A. repens the galactose residues were determined to be immunodominant.

Deep boreholes; Tiefe Bohrloecher

Energy Technology Data Exchange (ETDEWEB)

Bracke, Guido [Gesellschaft fuer Anlagen- und Reaktorsicherheit gGmbH Koeln (Germany); Charlier, Frank [NSE international nuclear safety engineering gmbh, Aachen (Germany); Geckeis, Horst [Karlsruher Institut fuer Technologie (Germany). Inst. fuer Nukleare Entsorgung; and others

2016-02-15

The report on deep boreholes covers the following subject areas: methods for safe enclosure of radioactive wastes, requirements concerning the geological conditions of possible boreholes, reversibility of decisions and retrievability, status of drilling technology. The introduction covers national and international activities. Further chapters deal with the following issues: basic concept of the storage in deep bore holes, status of the drilling technology, safe enclosure, geomechanics and stability, reversibility of decisions, risk scenarios, compliancy with safe4ty requirements and site selection criteria, research and development demand.

Proneoplastic effects of PGE2 mediated by EP4 receptor in colorectal cancer.

LENUS (Irish Health Repository)

Doherty, Glen A

2009-01-01

BACKGROUND: Prostaglandin E2 (PGE2) is the major product of Cyclooxygenase-2 (COX-2) in colorectal cancer (CRC). We aimed to assess PGE2 cell surface receptors (EP 1-4) to examine the mechanisms by which PGE2 regulates tumour progression. METHODS: Gene expression studies were performed by quantitative RT-PCR. Cell cycle was analysed by flow cytometry with cell proliferation quantified by BrdU incorporation measured by enzyme immunoassay. Immunohistochemistry was employed for expression studies on formalin fixed paraffin embedded tumour tissue. RESULTS: EP4 was the most abundant subtype of PGE2 receptor in HT-29 and HCA7 cells (which show COX-2 dependent PGE2 generation) and was consistently the most abundant transcript in human colorectal tumours (n = 8) by qRT-PCR (ANOVA, p = 0.01). G0\\/G1 cell cycle arrest was observed in HT-29 cells treated with SC-236 5 microM (selective COX-2 inhibitor) for 24 hours (p = 0.02), an effect abrogated by co-incubation with PGE2 (1 microM). G0\\/G1 arrest was also seen with a specific EP4 receptor antagonist (EP4A, L-161982) (p = 0.01). Treatment of HT-29 cells with either SC-236 or EP4A caused reduction in intracellular cAMP (ANOVA, p = 0.01). Early induction in p21WAF1\\/CIP1 expression (by qRT-PCR) was seen with EP4A treatment (mean fold increase 4.4, p = 0.04) while other genes remained unchanged. Similar induction in p21WAF1\\/CIP1 was also seen with PD153025 (1 microM), an EGFR tyrosine kinase inhibitor, suggesting EGFR transactivation by EP4 as a potential mechanism. Additive inhibition of HCA7 proliferation was observed with the combination of SC-236 and neutralising antibody to amphiregulin (AR), a soluble EGFR ligand. Concordance in COX-2 and AR localisation in human colorectal tumours was noted. CONCLUSION: COX-2 regulates cell cycle transition via EP4 receptor and altered p21WAF1\\/CIP1 expression. EGFR pathways appear important. Specific targeting of the EP4 receptor or downstream targets may offer a safer alternative

Exopolysaccharide (EPS synthesis by Oenococcus oeni: from genes to phenotypes.

Directory of Open Access Journals (Sweden)

Maria Dimopoulou

Full Text Available Oenococcus oeni is the bacterial species which drives malolactic fermentation in wine. The analysis of 50 genomic sequences of O. oeni (14 already available and 36 newly sequenced ones provided an inventory of the genes potentially involved in exopolysaccharide (EPS biosynthesis. The loci identified are: two gene clusters named eps1 and eps2, three isolated glycoside-hydrolase genes named dsrO, dsrV and levO, and three isolated glycosyltransferase genes named gtf, it3, it4. The isolated genes were present or absent depending on the strain and the eps gene clusters composition diverged from one strain to another. The soluble and capsular EPS production capacity of several strains was examined after growth in different culture media and the EPS structure was determined. Genotype to phenotype correlations showed that several EPS biosynthetic pathways were active and complementary in O. oeni. Can be distinguished: (i a Wzy-dependent synthetic pathway, allowing the production of heteropolysaccharides made of glucose, galactose and rhamnose, mainly in a capsular form, (ii a glucan synthase pathway (Gtf, involved in β-glucan synthesis in a free and a cell-associated form, giving a ropy phenotype to growth media and (iii homopolysaccharide synthesis from sucrose (α-glucan or β-fructan by glycoside-hydrolases of the GH70 and GH68 families. The eps gene distribution on the phylogenetic tree was examined. Fifty out of 50 studied genomes possessed several genes dedicated to EPS metabolism. This suggests that these polymers are important for the adaptation of O. oeni to its specific ecological niche, wine and possibly contribute to the technological performance of malolactic starters.

Home-based pre-exposure prophylaxis (PrEP services for gay and bisexual men: An opportunity to address barriers to PrEP uptake and persistence.

Directory of Open Access Journals (Sweden)

Steven A John

Full Text Available Gay, bisexual, and other men who have sex with men (GBM are disproportionately affected by the HIV epidemic. Despite the promise of pre-exposure prophylaxis (PrEP in reducing HIV transmission risk, barriers for uptake and persistence exist. We sought to identify whether GBM in a nationwide cohort who have not yet initiated PrEP (n = 906 would prefer to get PrEP-related care from a primary care provider (PCP compared to a specialist clinic or provider. We then sought to identify their level of interest and factors associated with preference for using home-based PrEP services (i.e., HB-PrEP, defined to participants as conducting HIV/STI self-testing from home with PrEP prescription mailing after an initial in-person clinic visit. We examined the associations of demographics, sexual HIV transmission risk, concern about frequent medical checkups associated with PrEP, health care access, and PrEP intentions with preferences for healthcare provider type and HB-PrEP. Concern about frequent medical checkups were associated with preferring a PCP for PrEP-related care, but men who perceived a barrier to bringing up the topic of PrEP with a doctor preferred a specialist clinic or provider more than a PCP. HB-PrEP was more appealing for younger men and those engaged in sexual HIV transmission risk, suggesting HB-PrEP could help reach GBM most vulnerable to HIV and in need of PrEP. HB-PrEP expansion has potential to increase PrEP uptake and persistence among GBM, particularly for men with barriers to clinic-based care and higher intentions to initiate PrEP. Clinical guidelines regarding HB-PrEP are needed to expand its use.

Long-term pumping test in borehole KR24 flow measurements

Energy Technology Data Exchange (ETDEWEB)

Rouhiainen, P.; Poellaenen, J. [PRG-Tec Oy, Espoo (Finland)

2005-09-15

The Difference Flow method can be used for the relatively fast determination of transmissivity and hydraulic head in fractures or fractured zones in cored boreholes. In this study, the Difference Flow method was used for hydraulic crosshole interference tests. The tests were performed in boreholes KR24 (pumped borehole) KR4, KR7, KR8, KRlO, KR14, KR22, KR22B, KR26, KR27, KR27B, KR28 and KR28B at Olkiluoto during the first and second quarters of 2004. The distance between the boreholes varies from approximately tens of meters to hundreds of meters. All the measurements were carried out in open boreholes, i.e. no packers were used. For interpretation, a normal single hole test was first performed in each borehole. Flow rates and drawdown were first measured both without pumping and with pumping the borehole under test. For practical reasons, the data set is neither complete nor similar in all tested boreholes. Connected flow to borehole KR24 was detected in all these boreholes. These flow responses were concentrated on a few zones. (orig.)

Microarray evaluation of EP4 receptor-mediated prostaglandin E2 suppression of 3T3-L1 adipocyte differentiation

International Nuclear Information System (INIS)

Sugimoto, Yukihiko; Tsuboi, Hiroaki; Okuno, Yasushi; Tamba, Shigero; Tsuchiya, Soken; Tsujimoto, Gozo; Ichikawa, Atsushi

2004-01-01

Prostaglandin E 2 (PGE 2 ) has been shown to negatively regulate adipogenesis. To explore to what extent PGE 2 inhibits the differentiation of cells to adipocytes and to examine whether its effect could be due to EP4 receptor signaling, we used microarrays to analyze the gene expression profiles of 3T3-L1 cells exposed to a differentiation cocktail supplemented with PGE 2 , AE1-329 (an EP4 agonist), or vehicle. The differentiation-associated responses in genes such as adipocytokines and enzymes related to lipid metabolism were largely weakened upon PGE 2 treatment. In particular, the expression of peroxisome proliferator activated receptor-γ and CCAAT/enhancer binding protein-α, genes playing a central role in adipogenesis, was greatly suppressed. PGE 2 appears to be ineffective to a subclass of insulin target genes such as hexokinase 2 and phosphofructokinase. Similar responses were produced in the differentiation-associated genes upon AE1-329 treatment. These results suggest that PGE 2 inhibits a crucial step of the adipocyte differentiation process by acting on the EP4 receptor in 3T3-L1 cells

A Proposed Borehole Scientific Laboratory in Quay County, New Mexico, USA

Science.gov (United States)

Nielson, Dennis; Eckels, Marc; Mast, Peter; Zellman, Mark; Creed, Robert

2017-04-01

Our team has received funding from the US Department of Energy to initiate a Deep Borehole Field Test that will develop a subsurface test site to evaluate the drilling and scientific aspects of deep borehole disposal of nuclear waste in crystalline rock. Phase 1 of the project will focus on Public Outreach and land acquisition whereas Phase 2 will generate a drilling and testing plan and secure regulatory approvals. Phase 3 will complete the Drilling and Testing Plan and Phase 4 will include the drilling and testing. Phase 5 will be devoted to borehole science and experiments with emplacement technology. Although we are specifically considering issues associated with the disposal of waste, this project is a proof of concept, and no waste will be emplaced at our site. In brief, the concept envisions an 8-1/2 inch open-hole completion at a depth of 5000 m in crystalline rock. There will be an extensive program of sample collection (including core) and analysis as well as geophysical logging and borehole testing. Critical issues will be low permeability in the crystalline rock as well as the ability to manage borehole quality. Our team has proposed a site in Quay County, New Mexico that has an 850 meter thick Paleozoic section overlying homogeneous Precambrian granite. A subsequent phase of the project may drill a second hole with a 17-1/2 inch completion located about 200 m from the first. Our long-term plan is that this site will be managed as a deep scientific observatory that also provides a facility for scientific experiments and testing of borehole infrastructure and drilling equipment.

Development and Test of a 1,000 Level 3C Fiber Optic Borehole Seismic Receiver Array Applied to Carbon Sequestration

Energy Technology Data Exchange (ETDEWEB)

Paulsson, Bjorn N.P. [Paulsson, Inc., Van Nuys, CA (United States)

2015-02-28

To address the critical site characterization and monitoring needs for CCS programs, US Department of Energy (DOE) awarded Paulsson, Inc. in 2010 a contract to design, build and test a fiber optic based ultra-large bandwidth clamped borehole seismic vector array capable of deploying up to one thousand 3C sensor pods suitable for deployment into high temperature and high pressure boreholes. Paulsson, Inc. has completed a design or a unique borehole seismic system consisting of a novel drill pipe based deployment system that includes a hydraulic clamping mechanism for the sensor pods, a new sensor pod design and most important – a unique fiber optic seismic vector sensor with technical specifications and capabilities that far exceed the state of the art seismic sensor technologies. These novel technologies were all applied to the new borehole seismic system. In combination these technologies will allow for the deployment of up to 1,000 3C sensor pods in vertical, deviated or horizontal wells. Laboratory tests of the fiber optic seismic vector sensors developed during this project have shown that the new borehole seismic sensor technology is capable of generating outstanding high vector fidelity data with extremely large bandwidth: 0.01 – 6,000 Hz. Field tests have shown that the system can record events at magnitudes much smaller than M-2.3 at frequencies up to 2,000 Hz. The sensors have also proved to be about 100 times more sensitive than the regular coil geophones that are used in borehole seismic systems today. The fiber optic seismic sensors have furthermore been qualified to operate at temperatures over 300°C (572°F). The fibers used for the seismic sensors in the system are used to record Distributed Temperature Sensor (DTS) data allowing additional value added data to be recorded simultaneously with the seismic vector sensor data.

Development of the nuclear weapons complex EP architecture

Energy Technology Data Exchange (ETDEWEB)

Murray, C.; Halbleib, L.

1996-07-01

The Nuclear Weapons Guidance Team is an interagency committee led by Earl Whiteman, DOE that chartered the generation of EP40100, Concurrent Qualification and its successor EP401099, Concurrent Engineering and Qualification. As this new philosophy of concurrent operations has evolved and as implementation has been initiated, conflicts and insufficiencies in the remaining Engineering Procedures (EPs) have become more apparent. At the Guidance Team meeting in November 1995, this issue was explored and several approaches were considered. It was concluded at this meeting, that a smaller set of interagency EPs described in a hierarchical system could provide the necessary interagency direction to support complex-wide implementation. This set consolidates many existing EP processes where consistency and commonality are critical to success of the extended enterprise. The Guidance Team subsequently chartered an interagency team to initiate development activity associated with the envisioned new EP set. This team had participation from seven Nuclear Weapons Complex (NWC) sites as well as DOE/AL and DP-14 (team members are acknowledged later in this report). Per the Guidance Team, this team, referred to as the Architecture Subcommittee, was to map out and define an EP Architecture for the interagency EPs, make recommendations regarding a more agile process for EP approval and suggest an aggressive timeline to develop the combined EPs. The Architecture Subcommittee was asked to brief their output at the February Guidance Team meeting. This SAND report documents the results of the Architecture Subcommittee`s recommendations.

Laboratory studies of fluid flow through borehole seals

International Nuclear Information System (INIS)

South, D.L.

1983-01-01

Boreholes in the vicinity of a nuclear waste repository must be reliably sealed to prevent rapid migration of radionuclide contaminated water from the vicinity of the repository to the accessible environment. Few data currently exist regarding the effectiveness of borehole sealing. The objective of this research was to assess the performance of borehole seals under laboratory conditions, particularly with regard to varying stress fields. The approach used to evaluate borehole seals was to compare flow through a sealed borehole with flow through intact rock. Granite, basalt, and tuff were tested, using either cement or bentonite as the seal material. The main conclusions reached as a result of the experiments is that currently existing materials are capable of forming high quality seals when placed under laboratory conditions. Variation of triaxial stress state about a borehole does not significantly affect seal performance if the rock is stiffer than the seal material. Temperature/moisture variations (drying) degraded the quality of cement seals significantly. Performance partially recovered upon resaturation. Significant remaining questions include field emplacement techniques; field vertification of plug quality; plug performance over long time periods, particularly with respect to temperature/moisture variations and chemical stability; and radionuclide sorption capabilities. Scale effects are also important, as shafts and drifts must be sealed as well as larger diameter boreholes

Stratigraphy of the Harwell boreholes

International Nuclear Information System (INIS)

Gallois, R.W.; Worssam, B.C.

1983-12-01

Seven boreholes, five of them partially cored, were drilled at the Atomic Energy Research Establishment at Harwell as part of a general investigation to assess the feasibility of storing low- and intermediate-level radioactive waste in underground cavities. Two of the deeper boreholes were almost wholly cored to provide samples for hydrogeological, hydrochemical, mineralogical, geochemical, geotechnical, sedimentological and stratigraphical studies to enable variations in lithology and rock properties to be assessed, both vertically and laterally, and related to their regional geological setting. This report describes the lithologies, main faunal elements and stratigraphy of the Cretaceous, Jurassic, Triassic and Carboniferous sequences proved in the boreholes. More detailed stratigraphical accounts of the late Jurassic and Cretaceous sequences will be prepared when current studies of the faunal assemblages are complete. (author)

Hydrological and hydrogeochemical investigations in boreholes

International Nuclear Information System (INIS)

Carlsson, L.; Olsson, T.

1985-07-01

Underground investigations in boreholes are presumed to be an important investigation technique for the detailed design of a final repository for nuclear waste. The siting of the repository will be based on surface investigations, but for detailed investigations when the access shafts are sunk, investigations in underground boreholes from the initial shafts and tunnels will be of importance. The hydrogeological investigations in boreholes aimed at testing and developing of hydrogeological techniques and instruments for use in an underground environment in order to reflect actual working and testing conditions. This report is the final report from the hydrogeological investigations in boreholes, and it summarizes the different activities carried out during the course of the program. Most of the included activities are reported in separate internal reports, and therefore only the most important results are included, together with the experiences and conclusions gained during the investigations. The hydrogeochemical part of the program is in a separate final report, consequently no hydrogeochemical information is in the current report. (Author)

Geophysical borehole logging in Lavia borehole - results and interpretation of sonic and tube wave measurements

International Nuclear Information System (INIS)

Andersson, P.; Stenberg, L.

1985-02-01

Swedish Nuclear Fuel and Waste Management Co, SKB has been contracted by Industrial Power Company LTD, TVO to perform geophysical logging in a borehole at Lavia in Western Finland. The logging has been conducted by Swedish Geological Co, SGAB in accordance with an agreement for cooperation with SKB. The depth of the borehole is 1001 m, diameter 56 mm and inclination 10-20 degrees to the vertical. The aim of the logging was to determine the various geophysical parameters in the borehole in order to interpret and understand the rock mass properties in the vicinity of the borehole. According to the contract the report covers the following main objectives: a technical description of the field work and the equipment used; a review of the theoretical base for the sonic and tube wave methods; an interpretation and presentation of the results obtained by sonic and tube wave mesurements. The evaluation of the sonic and tube wave measurements shows good correlation. On a qualitative basis there seems to be a correlation between tube wave generating points, the relative tube wave amplitudes and the hydraulic conductivity measurements performed as hydraulical tests between packers in the borehole. The low velocity anamalies in the sonic log are mainly caused by tectonic features like fractures and fracture zones but to some extent also by contacts between granite and diorite. The estimation of elastic properties of the rock mass from observation of tube wave velocity are in accordance with laboratory determinations made on core samples. (author)

Tidal modulation of temperature oscillations monitored in borehole Yaxcopoil-1 (Yucatán, Mexico)

Czech Academy of Sciences Publication Activity Database

Čermák, Vladimír; Bodri, L.; Šafanda, Jan

2009-01-01

Roč. 282, č. 1-4 (2009), s. 131-139 ISSN 0012-821X R&D Projects: GA AV ČR(CZ) IAA300120603; GA ČR(CZ) GA205/06/1181 Institutional research plan: CEZ:AV0Z30120515 Keywords : temperature monitoring * borehole convection * tidal forcing * recurrence quantification interval * (RQI) analysis * histograms cumulation technique Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 4.062, year: 2009

Working program for deep borehole investigations. HDB-6,7,8, borehole

International Nuclear Information System (INIS)

Hama, Katsuhiro; Takahashi, Kazuharu; Ishii, Eiichi; Takeuchi, Ryuji; Sasaki, Manabu; Kunimaru, Takanori; Eki, Nobuhiro; Matsui, Hiroya

2003-08-01

In the Horonobe Underground Research Laboratory project, a wide range of geoscientific research and development activities are planned to be performed in three phases, Surface-based Investigations (Phase I), Construction (Phase II) and Operations (Phase III), over period of 20 years. Surface-based investigations have been conducted since 2000. Main goals of the Horonobe project are; To establish comprehensive techniques for investigating the geological environment, and To develop a range of engineering techniques for deep underground applications. The specific goals of the surface-based investigations are, To construct geological models of the geological environment based on the surface-based investigations and develop an understanding of the deep geological environment (undisturbed, initial conditions) before excavation of the shaft and experimental drifts To formulate detailed design and plans for the construction of the shaft and experimental drifts, and To plan scientific investigations during the construction phase. Field investigations during the surface-based investigations phase are planned for completion by the end of 2005, with excavation of the main shaft, Phase 2 construction, planned to start in 2005. The diameter of the main shafts has provisionally been set at 6.5 meters and the proposed depth is 500 meters. Details of the geometry and depth of specific underground facilities, including the main shaft, the ventilation shaft and the drifts, will be defined using data on the geological environment obtained during the surface-based investigation phase. As part of the surface-based investigations, geological, geophysical, hydrogeological, hydrochemical and rock mechanical investigations were carried out. Deep borehole investigations started in 2000 in order to characterize the sedimentary rocks. Taking into account the status of the investigations as of April 2003 and the remaining time (i.e., three year) for the surface-based investigations, an

Hydrogeological investigations in two boreholes in the Stripa test station

International Nuclear Information System (INIS)

Hansson, K.; Almen, K.-E.; Ekman, L.

1978-01-01

The investigations included the following: water injection tests in a horizontal core-borehole, Dbh 2; hydrostatic pressure tests in Dbh2; determination of permeability in a vertical core-borehole, Dbh VI. The results of the water injection tests gave very little information due to the fact, that an air cushion was trapped in the borehole. The hydrostatic pressure tests in Dbh 2 were made in that part of the borehole, which is situated beyond the drift (45 - 97 m). Most of the pressure curves were difficult to interpret. The hydrostatic pressure in the section 89 - 97 m (end of the hole) was calculated to 1,67 Mpa. Near the end of the drift (46.00 - 49.71 m) the pressure was 0.22 Mpa. The permeability tests in Dbh VI were performed by measuring the water-flow and hydrostatic pressure in different levels. The calculated average permeability was 6.5x10 -10 m/s

Prostaglandin receptor EP3 regulates cell proliferation and migration with impact on survival of endometrial cancer patients.

Science.gov (United States)

Zhu, Junyan; Trillsch, Fabian; Mayr, Doris; Kuhn, Christina; Rahmeh, Martina; Hofmann, Simone; Vogel, Marianne; Mahner, Sven; Jeschke, Udo; von Schönfeldt, Viktoria

2018-01-02

Prostaglandin E2 (PGE2) receptor 3 (EP3) regulates tumor cell proliferation, migration, and invasion in numerous cancers. The role of EP3 as a prognostic biomarker in endometrial cancer remains unclear. The primary aim of this study was to analyze the prognostic significance of EP3 expression in endometrial cancer. We analyzed the EP3 expression of 140 endometrial carcinoma patients by immunohistochemistry. RL95-2 endometrial cancer cell line was chosen from four endometrial cancer cell lines (RL95-2, Ishikawa, HEC-1-A, and HEC-1-B) according to EP3 expression level. Treated with PGE2 and EP3 antagonist, RL95-2 cells were investigated by MTT, BrdU, and wound healing assay for functional assessment of EP3. EP3 staining differed significantly according to WHO tumor grading in both whole cohort (p = 0.01) and the subgroup of endometrioid carcinoma (p = 0.01). Patients with high EP3 expression in their respective tumors had impaired progression-free survival as well as overall survival in both cohorts above. EP3 expression in the overall cohort was identified as an independent prognostic marker for progression-free survival (HR 1.014, 95%CI 1.003-1.024, p = 0.01) when adjusted for age, stage, grading, and recurrence. Treatment with EP3 antagonists induced upregulation of estrogen receptor β and decreased activity of Ras and led to attenuated proliferation and migration of RL95-2 cells. EP3 seems to play a crucial role in endometrial cancer progression. In the context of limited systemic treatment options for endometrial cancer, this explorative analysis identifies EP3 as a potential target for diagnostic workup and therapy.

Immunohistochemical analysis based Ep-ICD subcellular localization index (ESLI) is a novel marker for metastatic papillary thyroid microcarcinoma

International Nuclear Information System (INIS)

Kunavisarut, Tada; Kak, Ipshita; MacMillan, Christina; Ralhan, Ranju; Walfish, Paul G

2012-01-01

Thyroid cancer is among the fastest growing malignancies; almost fifty-percent of these rapidly increasing incidence tumors are less than or equal to 1cm in size, termed papillary thyroid microcarcinoma (PTMC). The management of PTMC remains a controversy due to differing natural history of these patients. Epithelial cell adhesion molecule (EpCAM) is comprised of an extracellular domain (EpEx), a single transmembrane domain and an intracellular domain (Ep-ICD). Our group reported nuclear Ep-ICD correlated with poor prognosis in thyroid cancer (Ralhan et al., BMC Cancer 2010,10:331). Here in, we hypothesized nuclear and cytoplasmic accumulation of Ep-ICD and loss of membranous EpEx may aid in distinguishing metastatic from non-metastatic PTMC, which is an important current clinical challenge. To test our hypothesis, Ep-ICD and EpEx expression levels were analyzed in PTMC and the staining was correlated with metastatic potential of these carcinomas. Thirty-six PTMC patients (tumor size 0.5 - 1cm; metastatic 8 cases and non-metastatic 28 cases) who underwent total thyroidectomy were selected. The metastatic group consisted of patients who developed lymph node or distant metastasis at diagnosis or during follow up. The patients’ tissues were stained for Ep-ICD and EpEx using domain specific antibodies by immunohistochemistry and evaluated. PTMC patients with metastasis had higher scores for nuclear and cytoplasmic Ep-ICD immunostaining than the patients without metastasis (1.96 ± 0.86 vs. 1.22 ± 0.45; p = 0.007 and 5.37 ± 0.33 vs. 4.72 ± 1.07; p = 0.016, respectively). Concomitantly, the former had lower scores for membrane EpEx than the non-metastatic group (4.64 ± 1.08 vs. 5.64 ± 1.51; p = 0.026). An index of aggressiveness, Ep-ICD subcellular localization index (ESLI), was defined as sum of the IHC scores for accumulation of nuclear and cytoplasmic Ep-ICD and loss of membranous EpEx; ESLI = [Ep − ICD nuc + Ep − ICD cyt + loss of membranous EpEx]. Notably

Cost-effectiveness of Pre-Exposure Prophylaxis (PrEP) in preventing HIV-1 infections in rural Zambia: a modeling study

NARCIS (Netherlands)

Nichols, B.E.; Boucher, C.A.B.; van Dijk, J.H.; Thuma, P.E.; Nouwen, J.L.; Baltussen, R.; van de Wijgert, J.; Sloot, P.M.A.; van de Vijver, D.A.M.C.

2013-01-01

Background: Pre-exposure prophylaxis (PrEP) with tenofovir and emtricitabine effectively prevents new HIV infections. The optimal scenario for implementing PrEP where most infections are averted at the lowest cost is unknown. We determined the impact of different PrEP strategies on averting new

Borehole temperature variability at Hoher Sonnblick, Austria

Science.gov (United States)

Heinrich, Georg; Schöner, Wolfgang; Prinz, Rainer; Pfeiler, Stefan; Reisenhofer, Stefan; Riedl, Claudia

2016-04-01

The overarching aim of the project 'Atmosphere - permafrost relationship in the Austrian Alps - atmospheric extreme events and their relevance for the mean state of the active layer (ATMOperm)' is to improve the understanding of the impacts of atmospheric extreme events on the thermal state of the active layer using a combined measurement and modeling approach as the basis for a long-term monitoring strategy. For this purpose, the Sonnblick Observatory at the summit of Hoher Sonnblick (3106 m.a.s.l) is particularly well-suited due to its comprehensive long-term atmospheric and permafrost monitoring network (i.a. three 20 m deep boreholes since 2007). In ATMOperm, a robust and accurate permanent monitoring of active layer thickness at Hoher Sonnblick will be set up using innovative monitoring approaches by automated electrical resistivity tomography (ERT). The ERT monitoring is further supplemented by additional geophysical measurements such as ground penetrating radar, refraction seismic, electromagnetic induction and transient electromagnetics in order to optimally complement the gained ERT information. On the other hand, atmospheric energy fluxes over permafrost ground and their impact on the thermal state of permafrost and active layer thickness with a particular focus on atmospheric extreme events will be investigated based on physically-based permafrost modeling. For model evaluation, the borehole temperature records will play a key role and, therefore, an in-depth quality control of the borehole temperatures is an important prerequisite. In this study we will show preliminary results regarding the borehole temperature variability at Hoher Sonnblick with focus on the active layer. The borehole temperatures will be related to specific atmospheric conditions using the rich data set of atmospheric measurements of the site in order to detect potential errors in the borehole temperature measurements. Furthermore, we will evaluate the potential of filling gaps in

Final storage of radioactive waste in deep boreholes

International Nuclear Information System (INIS)

Eichmeyer, H.; Wolff, H.

1985-01-01

The plans of the Danish Atomic Energy Authority expect the storage of 4500 containers with high activity waste each weighing 15 tonnes in deep boreholes in rock salt over a period of 30 years. The Danish plans are concerned with the storage medium salt in one of the many salt mines in North Germany and Denmark with a depth of 1200 metres, because of the high plasticity, good thermal conductivity and non-permeability to liquids and gases. Eight deep boreholes with a diameter of 750 mm are provided in a circle of radius r=250 metres. With a deviation of 0 , the boreholes will be piped down to 1000 metres and after completion, will be filled with clay slurry and barium sulphate. At the start of storage of the waste in containers 6.8 metres long, the clay slurry is replaced by cement slurry with saturated NaCl solution. Another possibility is to fill the borehole volume with saturated NaCl solution, in order to let the convergence act on the annular space between the container and the borehole wall. After filling the borehole, the open borehole should be sealed over a distance of 200 metres with rock salt and over 50 metres with a concrete stopper. It is planned to provide a dense and corrosion-proof seal with bitumen above the concrete. (orig./GB) [de

Crosshole investigations - results from borehole radar investigations

International Nuclear Information System (INIS)

Olsson, O.; Falk, L.; Sandberg, E.; Forslund, O.; Lundmark, L.

1987-05-01

A new borehole radar system has been designed, built and tested. The system consists of borehole transmitter and receiver probes, a signal control unit for communication with the borehole probes, and a computer unit for storage and display of data. The system can be used both in singlehole and crosshole modes and probing ranges of 115 m and 300 m, respectively, have been obtained at Stripa. The borehole radar is a short pulse system which uses center frequencies in the range 20 to 60 MHz. Single hole reflection measurements have been used to identify fracture zones and to determine their position and orientation. The travel time and amplitude of the first arrival measured in a crosshole experiment can be used as input data in a tomographic analysis. (orig./DG)

30 CFR 75.1318 - Loading boreholes.

Science.gov (United States)

2010-07-01

... protect persons shall be done in the working place or other area where blasting is to be performed. (c) When loading boreholes drilled at an angle of 45 degrees or greater from the horizontal in solid rock... MANDATORY SAFETY STANDARDS-UNDERGROUND COAL MINES Explosives and Blasting § 75.1318 Loading boreholes. (a...

Dynamic Mechanical Properties of PMN/CNFs/EP Composites

International Nuclear Information System (INIS)

Shi Minxian; Huang Zhixiong; Qin Yan

2011-01-01

In this research, piezoelectric ceramic PMN(lead magnesium niobate-lead zirconate-lead titanate)/carbon nano-fibers(CNFs)/epoxy resin(EP) ccomposites were prepared and the dynamic mechanical properties and damping mechanism of PMN/CNFs/EP composites were investigated. The addition of CNFs into PMN/EP composite results in decrease of volume resistivity of the composite. When the concentration of CNFs is 0.6% weight of epoxy resin the volume resistivity of PMN/CNFs/EP composite is about 10 8 Ω·m. Dynamic mechanical analysis indicates that the loss factor, loss area, and damping temperature range of PMN/CNFs/EP composites increase with the CNFs content increasing till to 0.6% of weight of epoxy resin. When the CNFs content is more than 0.6% the damping properties of composites decrease oppositely. In PMN/CNFs/EP composites, the CNFs content 0.6% and the volume resistivity of PMN/CNFs/EP composites about 10 8 Ω·m just satisfy the practicing condition of piezo-damping, so the composites show optimal damping property.

Geophysical borehole logging and optical imaging of the boreholes KR34, KR35 and KR36, at Olkiluoto 2005

International Nuclear Information System (INIS)

Majapuro, J.

2005-09-01

Suomen Malmi Oy conducted geophysical borehole logging and optical imaging surveys of the boreholes KR34, KR35 and KR36 at the Olkiluoto site in Eurajoki during May - June 2005. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The methods applied are magnetic susceptibility, natural gamma radiation, gamma-gamma density, single point resistance, Wenner-resistivity, borehole radar, full waveform sonic and optical imaging. The assignment included the field work of all surveys, interpretation and processing of the acoustic and borehole radar data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Geophysical borehole logging and optical imaging of the boreholes KR34, KR35 and KR36, at Olkiluoto 2005

Energy Technology Data Exchange (ETDEWEB)

Majapuro, J. [Suomen Malmi Oy, Espoo (Finland)

2005-09-15

Suomen Malmi Oy conducted geophysical borehole logging and optical imaging surveys of the boreholes KR34, KR35 and KR36 at the Olkiluoto site in Eurajoki during May - June 2005. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The methods applied are magnetic susceptibility, natural gamma radiation, gamma-gamma density, single point resistance, Wenner-resistivity, borehole radar, full waveform sonic and optical imaging. The assignment included the field work of all surveys, interpretation and processing of the acoustic and borehole radar data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Utilization of test boreholes in prospecting and mining operations

International Nuclear Information System (INIS)

Sierak, J.P.

1987-01-01

Test boreholes are of fundamental importance for mining and prospecting operations. The drilling techniques are suited to the geological conditions and to the nature of the information desired. At Cogema, non-coring test boreholes, mainly drilled by a rotary percussive method, represent over 90% of the footage drilled; they achieve impressive performances at a cost which is by far less than that of coring test boreholes. The geological exploitation of these test boreholes is effected by a combined investigation of well logging and of cuttings. These investigations lead to an assessment for certain substances like uranium or coal or they mark the limits for favourable zones which alone will form the object of coring boreholes. In mining operations, boreholes indicate the definition for workable panels; they ensure at less cost the distribution of fluids, the forwarding of stowing material and the mine ventilation [fr

Core-logs of the vertical borehole V2

International Nuclear Information System (INIS)

Carlsson, L.; Egerth, T.; Westlund, B.; Olsson, T.

1982-08-01

In the hydrogeological programme of the Stripa Project, borehole V2 was prolonged to a final depth of 822 m. The previous core from 0-471.4 m was relogged. The drill core was logged with regard to rock characteristics, fracture frequency, dipping and filling. The results are presented as core-logs and fracture diagrams. Borehole V2 shows similar characteristics as found in other drillings in the Stripa Mine. It penetrates Stripa granite to its full depth. recorded fractures shows a clear predominance of medium-steep fractures, while flat-lying fractures are more sparsly occuring, a fact which is even more pronounced below 400 m depth. Due to the vertical direction of the borehole, steeply dipping fractures are underestimated in the core. The mean fracture frequency, related to the total length of the core, is 2.1 fractures/m. Chlorite, calcite and epidote are the dominating coating minerals in the fractures, each making up about 25-30 percent of all coated fractures. (Authors)

Hydraulic effects of unsealed boreholes. Numerical groundwater flow modelling of the Forsmark and Laxemar sites

International Nuclear Information System (INIS)

Bockgaard, Niclas

2011-06-01

The objective of the work was to investigate hydraulic effects of open and poorly sealed boreholes on groundwater flow conditions through simulations using a numerical groundwater model. Specifically, the boreholes KFM07A, KFM09A, and KFM09B in Forsmark and the boreholes KLX04, KLX06, and KLX10 in Laxemar were studied. The criteria for the selection of these boreholes were that the boreholes should represent typical conditions of the site, the borehole length should exceed 500 m, and that several major fractured zones should be intersected. The boreholes KFM07A and KLX06, respectively, were selected as reference boreholes for more detailed studies of different sealing schemes. The model setup of the Forsmark model followed the Forsmark 2.2 regional-scale conceptual hydrogeological model. The model domain was approximately 15 km (north-south) x 10 km (west- east) x 1.2 km (depth). The 131 deformation zones and three layers of superficial horizontal sheet joint were modelled deterministically. A stochastic discrete fracture network (DFN) representing fractures and minor deformation zones were also generated between the deterministic deformation zones inside central model volume. The side lengths of the square fractures were from 1,000 m down to 10 m. In order to resolve the details of flow in to and out from the borehole, a more detailed DFN was generated in a zone around the borehole KFM07A, where fractures down to a side length of 0.5 m were considered. The model setup of the Laxemar model followed the SDM-Site Laxemar (Laxemar 2.3) regional scale conceptual hydrogeological model. The model domain was approximately 12 km (north-south) x 20 km (west-east) x 2.1 km (depth). A number of 71 deformation zones were modelled deterministically, and one realization of a stochastic DFN, the so-called hydrogeological DFN model base case, was imported to the model. Similar to the Forsmark case, a more detailed DFN was also generated around the reference borehole KLX06. The

Hydraulic effects of unsealed boreholes. Numerical groundwater flow modelling of the Forsmark and Laxemar sites

Energy Technology Data Exchange (ETDEWEB)

Bockgaard, Niclas [Golder Associates AB, Stockholm (Sweden)

2011-06-15

The objective of the work was to investigate hydraulic effects of open and poorly sealed boreholes on groundwater flow conditions through simulations using a numerical groundwater model. Specifically, the boreholes KFM07A, KFM09A, and KFM09B in Forsmark and the boreholes KLX04, KLX06, and KLX10 in Laxemar were studied. The criteria for the selection of these boreholes were that the boreholes should represent typical conditions of the site, the borehole length should exceed 500 m, and that several major fractured zones should be intersected. The boreholes KFM07A and KLX06, respectively, were selected as reference boreholes for more detailed studies of different sealing schemes. The model setup of the Forsmark model followed the Forsmark 2.2 regional-scale conceptual hydrogeological model. The model domain was approximately 15 km (north-south) x 10 km (west- east) x 1.2 km (depth). The 131 deformation zones and three layers of superficial horizontal sheet joint were modelled deterministically. A stochastic discrete fracture network (DFN) representing fractures and minor deformation zones were also generated between the deterministic deformation zones inside central model volume. The side lengths of the square fractures were from 1,000 m down to 10 m. In order to resolve the details of flow in to and out from the borehole, a more detailed DFN was generated in a zone around the borehole KFM07A, where fractures down to a side length of 0.5 m were considered. The model setup of the Laxemar model followed the SDM-Site Laxemar (Laxemar 2.3) regional scale conceptual hydrogeological model. The model domain was approximately 12 km (north-south) x 20 km (west-east) x 2.1 km (depth). A number of 71 deformation zones were modelled deterministically, and one realization of a stochastic DFN, the so-called hydrogeological DFN model base case, was imported to the model. Similar to the Forsmark case, a more detailed DFN was also generated around the reference borehole KLX06. The

Optimal experimental design for placement of boreholes

Science.gov (United States)

Padalkina, Kateryna; Bücker, H. Martin; Seidler, Ralf; Rath, Volker; Marquart, Gabriele; Niederau, Jan; Herty, Michael

2014-05-01

Drilling for deep resources is an expensive endeavor. Among the many problems finding the optimal drilling location for boreholes is one of the challenging questions. We contribute to this discussion by using a simulation based assessment of possible future borehole locations. We study the problem of finding a new borehole location in a given geothermal reservoir in terms of a numerical optimization problem. In a geothermal reservoir the temporal and spatial distribution of temperature and hydraulic pressure may be simulated using the coupled differential equations for heat transport and mass and momentum conservation for Darcy flow. Within this model the permeability and thermal conductivity are dependent on the geological layers present in the subsurface model of the reservoir. In general, those values involve some uncertainty making it difficult to predict actual heat source in the ground. Within optimal experimental the question is which location and to which depth to drill the borehole in order to estimate conductivity and permeability with minimal uncertainty. We introduce a measure for computing the uncertainty based on simulations of the coupled differential equations. The measure is based on the Fisher information matrix of temperature data obtained through the simulations. We assume that the temperature data is available within the full borehole. A minimization of the measure representing the uncertainty in the unknown permeability and conductivity parameters is performed to determine the optimal borehole location. We present the theoretical framework as well as numerical results for several 2d subsurface models including up to six geological layers. Also, the effect of unknown layers on the introduced measure is studied. Finally, to obtain a more realistic estimate of optimal borehole locations, we couple the optimization to a cost model for deep drilling problems.

Geophysical borehole logging test procedure: Final draft

International Nuclear Information System (INIS)

1986-09-01

The purpose of geophysical borehole logging from the At-Depth Facility (ADF) is to provide information which will assist in characterizing the site geologic conditions and in classifying the engineering characteristics of the rock mass in the vicinity of the ADF. The direct goals of borehole logging include identification of lithologic units and their correlation from hole to hole, identification of fractured or otherwise porous or permeable zones, quantitative or semi-quantitative estimation of various formation properties, and evaluation of factors such as the borehole diameter and orientation. 11 figs., 4 tabs

Selected engineering properties and applications of EPS geofoam

Science.gov (United States)

Elragi, Ahmed Fouad

Expanded polystyrene (EPS) geofoam is a lightweight material that has been used in engineering applications since at least the 1950s. Its density is about a hundredth of that of soil. It has good thermal insulation properties with stiffness and compression strength comparable to medium clay. It is utilized in reducing settlement below embankments, sound and vibration damping, reducing lateral pressure on substructures, reducing stresses on rigid buried conduits and related applications. This study starts with an overview on EPS geofoam. EPS manufacturing processes are described followed by a review of engineering properties found in previous research work done so far. Standards and design manuals applicable to EPS are presented. Selected EPS geofoam-engineering applications are discussed with examples. State-of-the-art of experimental work is done on different sizes of EPS specimens under different loading rates for better understanding of the behavior of the material. The effects of creep, sample size, strain rate and cyclic loading on the stress strain response are studied. Equations for the initial modulus and the strength of the material under compression for different strain rates are presented. The initial modulus and Poisson's ratio are discussed in detail. Sample size effect on creep behavior is examined. Three EPS projects are shown in this study. The creep behavior of the largest EPS geofoam embankment fill is shown. Results from laboratory tests, mathematical modeling and field records are compared to each other. Field records of a geofoam-stabilized slope are compared to finite difference analysis results. Lateral stress reduction on an EPS backfill retaining structure is analyzed. The study ends with a discussion on two promising properties of EPS geofoam. These are the damping ability and the compressibility of this material. Finite element analysis, finite difference analysis and lab results are included in this discussion. The discussion with the

Study of borehole probing methods to improve the ground characterization

Science.gov (United States)

Naeimipour, Ali

Collecting geological information allows for optimizing ground control measures in underground structures. This includes understanding of the joints and discontinuities and rock strength to develop rock mass classifications. An ideal approach to collect such information is through correlating the drilling data from the roofbolters to assess rock strength and void location and properties. The current instrumented roofbolters are capable of providing some information on these properties but not fully developed for accurate ground characterization. To enhance existing systems additional instrumentation and testing was conducted in laboratory and field conditions. However, to define the geology along the boreholes, the use of probing was deemed to be most efficient approach for locating joints and structures in the ground and evaluation of rock strength. Therefore, this research focuses on selection and evaluation of proper borehole probes that can offer a reliable assessment of rock mass structure and rock strength. In particular, attention was paid to borehole televiewer to characterize rock mass structures and joints and development of mechanical rock scratcher for determination of rock strength. Rock bolt boreholes are commonly drilled in the ribs and the roof of underground environments. They are often small (about 1.5 inches) and short (mostly 2-3 meter). Most of them are oriented upward and thus, mostly dry or perhaps wet but not filled with water. No suitable system is available for probing in such conditions to identify the voids/joints and specifically to measure rock strength for evaluation of rock mass and related optimization of ground support design. A preliminary scan of available borehole probes proved that the best options for evaluation of rock structure is through analysis of borehole images, captured by optical televiewers. Laboratory and field trials with showed that these systems can be used to facilitate measurement of the location, frequency and

Borehole MET-1/04 near Metlika, between the External and Internal Dinarides (SE Slovenia

Directory of Open Access Journals (Sweden)

Marijan Poljak

2005-06-01

Full Text Available In the year 2004, a deep borehole MET/04 east of Metlika in Bela Krajina was drilled. It reached the depth of 841 meters. The aim of drilling was to catch thermal water that would be used for touristical purposes. The area where the borehole is located belongsto the transitional zone of the External to the Internal Dinarides. The first ones are characterized mainly by shallow water carbonate rocks of Mesozoic age, while the other ones are composed mainly of deep water clastic rocks also of Mesozoic age. Structurally,this zone consists of a series of the Dinaric, NW-SE oriented, thrusts along which the Internal Dinarides are thrusted over the External ones. The bore hole itself is located in the flysch sequence of Upper Cretaceous age that is deposed transgressivelly onto theUpper Jurassic limestone. The flysch, that is composed of conglomerate, breccia, calcarenite and marl, is drilled to 182,5 m of depth. Further, to the 275 of depth, there follow Lower Cretaceous limestones, that belong either to large olistolitic blocks in the base of the flysch series or to a tectonic block of the imbricated structure. To the bottom of the borehole, there follow mainly ref and perireefal limestones of Upper Jurassic age. The upper part of these is determined to be of Upper Malmian age, since the lower part couldbelong to Lower Malmian. In the borehole, two water bearing zones were determined. The first one is in the interval from 92,5 to 184, and the second one in the interval from 220 to 355 meters at the depth.

Basic data report for borehole Cabin Baby-1 deepening and hydrologic testing. Waste Isolation Pilot Plant (WIPP) project, southeastern New Mexico

International Nuclear Information System (INIS)

Beauheim, R.L.; Hassinger, B.W.; Klaiber, J.A.

1983-12-01

Borehole Cabin Baby-1 was originally drilled to a depth of 4159.0 feet below kelly bushing (8.0 feet above ground surface) in 1974 and 1975 as a ''wildcat'' hydrocarbon exploratory well. Control of the borehole was given to the US Department of Energy (DOE) after it was found to be a ''dry hole''. Cabin Baby-1 was reentered, deepened, and hydrologically tested in August and September 1983. The well is located in Section 5, T23S, R31E, just outside the limit of WIPP Zone III, approximately 2.5 miles south of the WIPP exploratory shaft. The deepening and testing of Cabin Baby-1 was undertaken for several reasons: to provide data on the hydrologic properties, including hydrostatic head potential of selected permeable zones in the Bell Canyon Formation; to provide representative fluid samples from selected permeable zones in the Bell Canyon Formation for determination of fluid composition and density; and to define further the stratigraphy of the upper Bell Canyon Formation at the Cabin Baby-1 location. The borehole was deepened from the previous total depth to a new depth of 4298.6 feet below kelly bushing by continuous coring. Field operations related to deepening and logging of the borehole began August 12, 1983 and were completed August 30, 1983. Hydrologic testing activities began August 30, 1983 and were completed September 29, 1983. Drill-stem tests were conducted in four zones in the Bell Canyon Formation, and one test of the Salado Formation was performed. Fluid samples were collected from the Hays and Olds sandstones of the Bell Canyon Formation

Decrease in zinc adsorption onto soil in the presence of EPS-rich and EPS-poor Pseudomonas aureofaciens.

Science.gov (United States)

Drozdova, O Yu; Pokrovsky, O S; Lapitskiy, S A; Shirokova, L S; González, A G; Demin, V V

2014-12-01

The adsorption of Zn onto the humic and illuvial horizons of the podzol soil in the presence of soil bacteria was studied using a batch-reactor technique as a function of the pH (from 2 to 9) and the Zn concentration in solution (from 0.076mM to 0.760mM). Exopolysaccharides-forming aerobic heterotrophs Pseudomonas aureofaciens were added at 0.1 and 1.0gwetL(-1) concentrations to two different soil horizons, and Zn adsorption was monitored as a function of the pH and the dissolved-Zn concentration. The pH-dependent adsorption edge demonstrated more efficient Zn adsorption by the humic horizon than the mineral horizon at otherwise similar soil concentrations. The Zn adsorption onto the EPS-poor strain was on slightly lower than that onto EPS-rich bacteria. Similar differences in the adsorption capacities between the soil and bacteria were also detected by "langmuirian" constant-pH experiments conducted in soil-Zn and bacteria-Zn binary systems. The addition of 0.1gwetL(-1)P. aureofaciens to a soil-bacteria system (4gdryL(-1)soil) resulted in statistically significant decrease in the adsorption yield, which was detectable from both the pH-dependent adsorption edge and the constant-pH isotherm experiments. Increasing the amount of added bacteria to 1gwetL(-1) further decreased the overall adsorption in the full range of the pH. This decrease was maximal for the EPS-rich bacteria and minimal for the EPS-poor bacteria (a factor of 2.8 and 2.2 at pH=6.9, respectively). These observations in binary and ternary systems were further rationalized by linear-programming modeling of surface equilibria that revealed the systematic differences in the number of binding sites and the surface-adsorption constant of zinc onto the two soil horizons with and without bacteria. The main finding of this work is that the adsorption of Zn onto the humic soil-bacteria system is lower than that in pure, bacteria-free soil systems. This difference is statistically significant (psoil particles

Highlights from e-EPS: Jean-Michel Raimond wins EPS Edison-Volta Prize 2014

CERN Multimedia

Martina Knoop, e-EPS News

2014-01-01

e-EPS News is a monthly addition to the CERN Bulletin line-up, showcasing articles from e-EPS – the European Physical Society newsletter – as part of a collaboration between the two publications.   The European Physical Society has the pleasure to announce that the 2014 EPS Edison-Volta Prize is awarded to Jean-Michel Raimond for “seminal contribution to physics (that) have paved the way for novel explorations of quantum mechanics and have opened new routes in quantum information processing”. J.-M. Raimond’s PhD thesis was supervised by Serge Haroche at the École Normale Supérieure in Paris, France, in the early 1980′s, and together S. Haroche, M. Brune and J.-M. Raimond have built an extremely successful research group since then. J.-M. Raimond has made seminal contributions to the development of cavity QED experiments, in particular involving circular Rydberg atoms interacting with very high-Q superc...

BASIMO - Borehole Heat Exchanger Array Simulation and Optimization Tool

Science.gov (United States)

Schulte, Daniel O.; Bastian, Welsch; Wolfram, Rühaak; Kristian, Bär; Ingo, Sass

2017-04-01

Arrays of borehole heat exchangers are an increasingly popular source for renewable energy. Furthermore, they can serve as borehole thermal energy storage (BTES) systems for seasonally fluctuating heat sources like solar thermal energy or district heating grids. The high temperature level of these heat sources prohibits the use of the shallow subsurface for environmental reasons. Therefore, deeper reservoirs have to be accessed instead. The increased depth of the systems results in high investment costs and has hindered the implementation of this technology until now. Therefore, research of medium deep BTES systems relies on numerical simulation models. Current simulation tools cannot - or only to some extent - describe key features like partly insulated boreholes unless they run fully discretized models of the borehole heat exchangers. However, fully discretized models often come at a high computational cost, especially for large arrays of borehole heat exchangers. We give an update on the development of BASIMO: a tool, which uses one dimensional thermal resistance and capacity models for the borehole heat exchangers coupled with a numerical finite element model for the subsurface heat transport in a dual-continuum approach. An unstructured tetrahedral mesh bypasses the limitations of structured grids for borehole path geometries, while the thermal resistance and capacity model is improved to account for borehole heat exchanger properties changing with depth. Thereby, partly insulated boreholes can be considered in the model. Furthermore, BASIMO can be used to improve the design of BTES systems: the tool allows for automated parameter variations and is readily coupled to other code like mathematical optimization algorithms. Optimization can be used to determine the required minimum system size or to increase the system performance.

EpCAM aptamer-functionalized polydopamine-coated mesoporous silica nanoparticles loaded with DM1 for targeted therapy in colorectal cancer

Directory of Open Access Journals (Sweden)

Li Y

2017-08-01

Full Text Available Yang Li,1,* Yanhong Duo,2,3,* Shiyun Bao,1 Lisheng He,4 Kai Ling,5 Jinfeng Luo,4 Yue Zhang,1 Hao Huang,2 Han Zhang,2 Xiaofang Yu1 1Department of Hepatobiliary and Pancreas Surgery, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, 2Shenzhen Engineering Laboratory of Phosphorene and Optoelectronics, Collaborative Innovation Center for Optoelectronic Science and Technology, Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, 3Key Laboratory of Plant Cell Activities and Stress Adaptation, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou, 4Department of Pathology, 5Institute of Respiratory Diseases, Second Clinical Medical College of Jinan University, Shenzhen People’s Hospital, Shenzhen, China *These authors contributed equally to this work Abstract: DM1, a maytansine derivative, is a highly potential cytotoxic agent but with severe side effects; therefore, its application in clinical cancer therapy is limited. Here, in order to mitigate this intrinsic drawback of DM1, we developed mesoporous silica nanoparticles (MSNs loaded with DM1 and surface-decorated with hydrochloride dopamine (PDA, polyethylene glycol (PEG, and epithelial cell adhesion molecule (EpCAM aptamer (APt for the targeted treatment of colorectal cancer (CRC. In this system, the PDA coating could be used as pH-sensitive gatekeepers to control the release of DM1 from MSNs in response to the pH stimulus and EpCAM APt-guided active targeting enables the increased delivery of DM1 to CRC as well as a reduction in toxicity and side effects by minimizing the exposure of normal tissues to DM1. Results demonstrated that DM1 inhibited the formation of microtubules and induced apoptosis in tumor cells via caspase signaling. In comparison with the control groups, the MSNs-DM1@PDA-PEG-APt bioconjugates exhibited

Conceptual Design and Requirements for Characterization and Field Test Boreholes: Deep Borehole Field Test

Energy Technology Data Exchange (ETDEWEB)

Kuhlman, Kristopher L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Brady, Patrick Vane [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); MacKinnon, Robert J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Heath, Jason E. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Herrick, Courtney G. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Jensen, Richard P. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hadgu, Teklu [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Birkholzer, Jens [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Freifeld, Barry M. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Daley, Tom [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2015-09-24

Deep Borehole Disposal (DBD) of high-level radioactive wastes has been considered an option for geological isolation for many years (Hess et al. 1957). Recent advances in drilling technology have decreased costs and increased reliability for large-diameter (i.e., ≥50 cm [19.7”]) boreholes to depths of several kilometers (Beswick 2008; Beswick et al. 2014). These advances have therefore also increased the feasibility of the DBD concept (Brady et al. 2009; Cornwall 2015), and the current field test, introduced herein, is a demonstration of the DBD concept and these advances.

Radiometric calipers for borehole logging

International Nuclear Information System (INIS)

Charbucinski, J.; Wylie, A.W.; Jarrett, R.G.

1976-01-01

Two versions of a radiometric-type caliper for measuring borehole diameter are described. One, based on the bow-spring principle, is suitable for percussion (exploration) drill holes. The other, which utilizes hemispherical wall contactors actuated by springs, is suitable for blast holes. Both utilize low-power radioactive sources and employ a scintillation detector to measure the 'inverse-square law' response of the device to changes in borehole radius. The performance of the device is examined and examples of its use are illustrated. (author)

Measuring depth in boreholes

International Nuclear Information System (INIS)

Hodson, G.M.

1979-01-01

This invention relates to a method of determining the depth of rock strata and other features of a borehole. It may be employed with particular advantage when access to the top of the borehole is difficult, for example in underwater operations. A radioactive marker, such as a source of gamma rays, is positioned near the top of the riser of a sub-sea wellhead structure. A radiation detector is lowered between the marker and a radioactive stratum and the length of line supplied is measured on the floating platform. This enables the depth of the stratum to be measured irrespective of tidal variations of the height of the platform. (U.K.)

Sealing of investigation boreholes, Phase 4 - Final report

Energy Technology Data Exchange (ETDEWEB)

Pusch, Roland [Drawrite AB, Luleaa Technical University, Luleaa (Sweden); Ramqvist, Gunnar [El-Tekno AB, Figeholm (Sweden); Bockgaard, Niclas [Golder Associates, Goeteborg (Sweden); Ekman, Lennart [LE Geokonsult AB, Baelinge (Sweden)

2011-09-15

The report describes the outcome of Phase 4 of the project 'Sealing of investigation boreholes', which deals with 1) characterization and planning of borehole sealing, 2) performance and quality assessment, 3) sealing of large diameter holes, and 4) interaction of clay and concrete plugs. A specific goal was to find ways to characterize, plan and seal of boreholes so that their impact on the overall hydraulic performance of the repository rock can predicted and controlled. The work comprised selection of representative 'reference holes' at the Laxemar and Forsmark sites for development of a general programme for planning and simulating implementation of borehole plugging campaigns, considering also cost issues. A second aim was to define and quantify the role of seals in the reference holes for finding out how important sealing really is. A third was to test a practical way to seal large diameter boreholes and a fourth to find out how concrete matures and performs in contact with smectite clay. The study demonstrated, in conclusion, the need for developing techniques for preparing deep boreholes before lasting seals are installed in them, since poor sealing can short-circuit hydraulically important fracture zones intersected by the holes. The practically oriented sealing activities showed that the technique developed for tight sealing of large-diameter boreholes is practical and feasible. The issue of chemical stability was investigated by testing the performance and constitution of a plug consisting of CBI concrete in contact with smectite-rich seals for almost three years. This study showed that none of them underwent substantial degradation in this period of time, but chemical reactions and thereby generated changes in physical behaviour of the plug components had taken place, particularly in the clay. The rate of degradation is, however, not yet known. It was concluded from this study that it is suitable to carry out a corresponding

Sealing of investigation boreholes, Phase 4 - Final report

International Nuclear Information System (INIS)

Pusch, Roland; Ramqvist, Gunnar; Bockgaard, Niclas; Ekman, Lennart

2011-09-01

The report describes the outcome of Phase 4 of the project 'Sealing of investigation boreholes', which deals with 1) characterization and planning of borehole sealing, 2) performance and quality assessment, 3) sealing of large diameter holes, and 4) interaction of clay and concrete plugs. A specific goal was to find ways to characterize, plan and seal of boreholes so that their impact on the overall hydraulic performance of the repository rock can predicted and controlled. The work comprised selection of representative 'reference holes' at the Laxemar and Forsmark sites for development of a general programme for planning and simulating implementation of borehole plugging campaigns, considering also cost issues. A second aim was to define and quantify the role of seals in the reference holes for finding out how important sealing really is. A third was to test a practical way to seal large diameter boreholes and a fourth to find out how concrete matures and performs in contact with smectite clay. The study demonstrated, in conclusion, the need for developing techniques for preparing deep boreholes before lasting seals are installed in them, since poor sealing can short-circuit hydraulically important fracture zones intersected by the holes. The practically oriented sealing activities showed that the technique developed for tight sealing of large-diameter boreholes is practical and feasible. The issue of chemical stability was investigated by testing the performance and constitution of a plug consisting of CBI concrete in contact with smectite-rich seals for almost three years. This study showed that none of them underwent substantial degradation in this period of time, but chemical reactions and thereby generated changes in physical behaviour of the plug components had taken place, particularly in the clay. The rate of degradation is, however, not yet known. It was concluded from this study that it is suitable to carry out a corresponding investigation of the plugs

EP 1000 -The European Passive Plant

International Nuclear Information System (INIS)

Cummins, Ed; Oyarzabal, Mariano; Saiu, Gianfranco

1998-01-01

A group of European utilities, along with Westinghouse and its industrial partner GENESI (an Italian consortium including ANSALDO and FIAT) initiated a program to evaluate Westinghouse passive nuclear plant technology for application in Europe. The European utility group consisted of: Agrupacion electrica para al Desarrollo Technologico Nuclear (DTN), Spain; Electricite de France; ENEL, SpA., Italy; IVO Power Engineering, Ltd., Finland; Scottish Nuclear Limited (acting for itself on behalf of Nuclear Electric plc, U.K.; Tractebel Energy Engineering, Belgium; UAK (represented by NOK-Beznau), Switzerland; and Vattenfall AB, Ringhals, Sweden. The European Passive Plant (EPP) program, which began in 1994, is an evaluation of the Westinghouse 600 MWe AP 600 and 1000 MWe Simplified Pressurized Water Reactor (SPWR) designs in meeting the European Utility Requirements (EUR), and where necessary, modifying the design to achieve compliance. Phase 1 or the EPP program was completed and included the two major tasks of evaluating the effect of the EUR on the Westinghouse nuclear island and developing the EP 1000, a 1000 MWe passive plant reference design that conforms to the EUR and would be licensable in Europe. The EP 1000 closely follows the Westinghouse SPWR design for safety systems and containment and the AP 600 design for auxiliary systems. It also includes features that where required to meet the EUR and key European licensing requirements. The primary circuit of the EP 1000 retains most of the general features of the current-day designs, but some evolutionary features to enhance reliability, simplicity of operation, ease of maintenance, and plant safety have been incorporated into the design. The core, reactor vessel, and reactor internals of the EP 1000 are similar to those of currently operating Westinghouse PWR plants, but several new features are included to enhance the performance characteristics. The basic EP 1000 safety philosophy is based on use of inherent

Extracellular polymeric substances (EPS) producing bacterial strains of municipal wastewater sludge: isolation, molecular identification, EPS characterization and performance for sludge settling and dewatering.

Science.gov (United States)

Bala Subramanian, S; Yan, S; Tyagi, R D; Surampalli, R Y

2010-04-01

Wastewater treatment plants often face the problems of sludge settling mainly due to sludge bulking. Generally, synthetic organic polymer and/or inorganic coagulants (ferric chloride, alum and quick lime) are used for sludge settling. These chemicals are very expensive and further pollute the environment. Whereas, the bioflocculants are environment friendly and may be used to flocculate the sludge. Extracellular polymeric substances (EPS) produced by sludge microorganisms play a definite role in sludge flocculation. In this study, 25 EPS producing strains were isolated from municipal wastewater treatment plant. Microorganisms were selected based on EPS production properties on solid agar medium. Three types of EPS (slime, capsular and bacterial broth mixture of both slime and capsular) were harvested and their characteristics were studied. EPS concentration (dry weight), viscosity and their charge (using a Zetaphoremeter) were also measured. Bioflocculability of obtained EPS was evaluated by measuring the kaolin clay flocculation activity. Six bacterial strains (BS2, BS8, BS9, BS11, BS15 and BS25) were selected based on the kaolin clay flocculation. The slime EPS was better for bioflocculation than capsular EPS and bacterial broth. Therefore, extracted slime EPS (partially purified) from six bacterial strains was studied in terms of sludge settling [sludge volume index (SVI)] and dewatering [capillary suction time (CST)]. Biopolymers produced by individual strains substantially improved dewaterability. The extracted slime EPS from six different strains were partially characterized. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

Classification of lithological units based on geophysical borehole logging - data from the Stripa mine

International Nuclear Information System (INIS)

Triumf, C.A.

1992-06-01

At the Crosshole site, located at the 360 m level in the Stripa mine, six boreholes F1-F6 have been drilled in a fanlike fashion. To achieve further knowledge of the geological conditions in the rock volumes outside the major tectonized zones, a classification of the pseudo-lithology has been carried out using data from boreholes F3-F6. The analysis has been supported by determination of density and magnetic susceptibility on core samples from boreholes F1-F5. This study demonstrates that the bulk of the tectonically less disturbed rock, forming the matrix in a network of dominant tectonical features, can be considered as homogeneous according to the silicate density. Three volumes with deviating lithology have however been identified in more than one borehole. Furthermore narrow sections are encountered, showing mineralogical, and probably also, micro-structural deviations from the normal granite. These narrow sections are irregularly spread along the boreholes. Their irregular distribution and narrowness, prevents correlation between boreholes. The result of the lithology identification is displayed using a modified Briggs cube. The method used in this project is applicable in many stages of an investigation programme where different disciplines are co-operating and partly complex information must be passed between individuals. (au)

Family planning providers' role in offering PrEP to women.

Science.gov (United States)

Seidman, Dominika; Weber, Shannon; Carlson, Kimberly; Witt, Jacki

2018-03-09

Pre-exposure prophylaxis (PrEP) provides a radically different HIV prevention option for women. Not only is PrEP the first discrete, woman-controlled method that is taken in advance of exposure, but it is both safe and highly effective, offering over 90% protection if taken daily. While multiple modalities of PrEP are in development ranging from vaginal rings to injectables and implants, only PrEP with oral tenofovir/emtricitabine is currently FDA-approved. Family planning clinics provide key access points for many women to learn about and obtain PrEP. By incorporating PrEP services into family planning care, family planning providers have the opportunity to meet women's expectations, ensure women are aware of and offered comprehensive HIV prevention options, and reverse emerging disparities in PrEP access. Despite real and perceived barriers to integrating PrEP into family planning care, providing PrEP services, ranging from education to onsite provision, is not only possible but an important component of providing high-quality sexual and reproductive healthcare to women. Lessons learned from early adopters will help guide those in family planning settings initiating or enhancing PrEP services. Copyright © 2018. Published by Elsevier Inc.

Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design.

Energy Technology Data Exchange (ETDEWEB)

Cochran, John R. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Hardin, Ernest [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-07-01

This report presents conceptual design information for a system to handle and emplace packages containing radioactive waste, in boreholes 16,400 ft deep or possibly deeper. Its intended use is for a design selection study that compares the costs and risks associated with two emplacement methods: drill-string and wireline emplacement. The deep borehole disposal (DBD) concept calls for siting a borehole (or array of boreholes) that penetrate crystalline basement rock to a depth below surface of about 16,400 ft (5 km). Waste packages would be emplaced in the lower 6,560 ft (2 km) of the borehole, with sealing of appropriate portions of the upper 9,840 ft (3 km). A deep borehole field test (DBFT) is planned to test and refine the DBD concept. The DBFT is a scientific and engineering experiment, conducted at full-scale, in-situ, without radioactive waste. Waste handling operations are conceptualized to begin with the onsite receipt of a purpose-built Type B shipping cask, that contains a waste package. Emplacement operations begin when the cask is upended over the borehole, locked to a receiving flange or collar. The scope of emplacement includes activities to lower waste packages to total depth, and to retrieve them back to the surface when necessary for any reason. This report describes three concepts for the handling and emplacement of the waste packages: 1) a concept proposed by Woodward-Clyde Consultants in 1983; 2) an updated version of the 1983 concept developed for the DBFT; and 3) a new concept in which individual waste packages would be lowered to depth using a wireline. The systems described here could be adapted to different waste forms, but for design of waste packaging, handling, and emplacement systems the reference waste forms are DOE-owned high- level waste including Cs/Sr capsules and bulk granular HLW from fuel processing. Handling and Emplacement Options for Deep Borehole Disposal Conceptual Design July 23, 2015 iv ACKNOWLEDGEMENTS This report has

Sorption of ferrous iron by EPS from the acidophilic bacterium Acidiphilium Sp.: A mechanism proposal

Energy Technology Data Exchange (ETDEWEB)

Tapia, J.M.; MuNoz, J.; Gonzlez, F.; Blazquez, M.L.; Ballester, A.

2016-07-01

The aim of this work was to assess the uptake of Fe(II) by extracellular polymeric substances (EPS) from the acidophilic bacterium Acidiphillium 3.2Sup(5). These EPS were extracted using EDTA. EPS of A. 3.2Sup(5) loaded in sorption tests with Fe(II), were characterized using the following experimental techniques: scanning electron microscopy (SEM) with energy dispersive X-ray microanalysis (EDX), X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The experimental results indicate that EPS adsorb ferrous iron according to Freundlich model with a metal sorption uptake of K = 1.14 mg1−1/n L1/n g−1 and a sorption intensity of 1/n = 1.26. In addition, ferrous iron sorption by EPS took place by preferential interaction with the carboxyl group which promotes the formation of ferrous iron oxalates (FeC2O4). Since the interaction reaction was reversible (Log K = 0.77 ± 0.33), that means that the cation sorption can be reversed at convenience. (Author)

Detection of buried pipes by polarimetric borehole radar; Polarimetric borehole radar ni yoru maisetsukan no kenshutsu jikken

Energy Technology Data Exchange (ETDEWEB)

Sato, M.; Niitsuma, H. [Tohoku University, Sendai (Japan); Nakauchi, T. [Osaka Gas Co. Ltd., Osaka (Japan)

1997-05-27

If the borehole radar is utilized for detection of buried pipes, the underground radar measurement becomes possible even in the situation where the mesurement on the earth surface is difficult, for example, such a place as under the road where there is much traffic. However, since buried pipes are horizontally installed and the existing borehole radar can send/receive only vertical polarization, the measurement conducted comes to be poor in efficiency from a viewpoint of the polarization utilization. Therefore, by introducing the polarimetric borehole radar to the detection of buried pipes, a basic experiment was conducted for the effective detection of horizontal buried pipes. Proposing the use of a slot antenna which can send/receive horizontal polarization in borehole in addition to a dipole antenna which sends/receives vertical polarization, developed was a step frequency type continuous wave radar of a network analyzer basis. As a result of the experiment, it was confirmed that reflection from buried pipes is largely dependent on polarization. Especially, it was found that in the slot dipole cross polarization mesurement, reflection from buried pipes can be emphasized. 4 refs., 5 figs.

Directional borehole antenna - Theory

International Nuclear Information System (INIS)

Falk, L.

1992-02-01

A directional antenna has been developed for the borehole radar constructed during phase 2 of the Stripa project. The new antenna can determine the azimuth of a strong reflector with an accuracy of about 3 degrees as confirmed during experiments in Stripa, although the ratio of borehole diameter to wavelength is small, about 0.03. The antenna synthesizes the effect of a loop antenna rotating in the borehole from four signals measured in turn by a stationary antenna. These signals are also used to calculate an electric dipole signal and a check sum which is used to examine the function of the system. The theory of directional antennas is reviewed and used to design an antenna consisting of four parallel wires. The radiation pattern of this antenna is calculated using transmission line theory with due regard to polarization, which is of fundamental importance for the analysis of directional data. In particular the multipole expansion of the field is calculated to describe the antenna radiation pattern. Various sources of error, e.g. the effect of the borehole, are discussed and the methods of calibrating the antenna are reviewed. The ambiguity inherent in a loop antenna can be removed by taking the phase of the signal into account. Typical reflectors in rock, e.g. fracture zones an tunnels, may be modelled as simple geometrical structures. The corresponding analysis is described and exemplified on measurements from Stripa. Radar data is nowadays usually analyzed directly on the computer screen using the program RADINTER developed within the Stripa project. An algorithm for automatic estimation of the parameters of a reflector have been tested with some success. The relation between measured radar data and external coordinates as determined by rotational indicators is finally expressed in terms of Euler angles. (au)

Heavy quark physics in ep collisions at LEP+LHC

International Nuclear Information System (INIS)

Ali, A.; Barreiro, F.; Troconiz, J.F. de; Schuler, G.A.; Bij, J.J. van der

1990-12-01

We study electroweak production of heavy quarks - charm, beauty, and top - in deep inelastic electron-proton collisions at the proposed LEP+LHC collider at CERN. The assumed energy for the collisions is E e =50 GeV, E p =8000 GeV, providing an ep center of mass energy, √s≅1.26 TeV. We invoke the boson-gluon fusion model to estimate theoretical cross sections and distributions for the heavy quarks. Higher order QCD corrections are only approximately taken into account, by assuming a (normalization) K-factor of 2 for the charm and beauty quark production rates and incorporating the parton shower cascades. With these assumptions and the parameterization of Eichten et al. for the structure functions (EHLQ, set 1), we find the following cross sections: σ(ep→c+X)≅O(3 μb), σ(ep→b+X)≅O(40 nb), and σ(ep→t+X)≅4 pb for m t =120 GeV, decreasing to 0.5 pb for m t =250 GeV. These cross sections would provide O(6x10 9 ) charmed hadrons, O(8x10 7 ) beauty hadrons, and O(10 3 ) top hadrons, for an integrated ep luminosity of 1000 pb -1 . The heavy quark rates in ep collisions are considerably smaller than the corresponding rates in pp collisions at LHC, with √s=16 TeV. This gives a clear advantage to pp collisions for top searches. However, for the charmed and beauty quarks only a tiny fraction of the cross sections in p+p→Q+X can be triggered in comparison to the corresponding cross sections in e+p→Q+X, resulting in comparable number of measured heavy quark events in the ep and pp mode. We sketch the energy-momentum profile of heavy quark events in ep collisions and illustrate the kind of analyses that experiments at the LEP+LHC collider would undertake to quantitatively study heavy quark physics. In particular, prospects of measuring the particle-antiparticle mixing parameter x s =ΔM/Γ for the B s 0 -anti B s 0 meson system are evaluated, and search strategies for the top quark in ep collisions are presented. (orig.)

Analysis and interpretation of borehole hydraulic tests in deep boreholes: principles, model development, and applications

International Nuclear Information System (INIS)

Pickens, J.F.; Grisak, G.E.; Avis, J.D.; Belanger, D.W.

1987-01-01

A review of the literature on hydraulic testing and interpretive methods, particularly in low-permeability media, indicates a need for a comprehensive hydraulic testing interpretive capability. Physical limitations on boreholes, such as caving and erosion during continued drilling, as well as the high costs associated with deep-hole rigs and testing equipment, often necessitate testing under nonideal conditions with respect to antecedent pressures and temperatures. In these situations, which are common in the high-level nuclear waste programs throughout the world, the interpretive requirements include the ability to quantitatively account for thermally induced pressure responses and borehole pressure history (resulting in a time-dependent pressure profile around the borehole) as well as equipment compliance effects in low-permeability intervals. A numerical model was developed to provide the capability to handle these antecedent conditions. Sensitivity studies and practical applications are provided to illustrate the importance of thermal effects and antecedent pressure history. It is demonstrated theoretically and with examples from the Swiss (National Genossenschaft fuer die Lagerung radioaktiver Abfaelle) regional hydrogeologic characterization program that pressure changes (expressed as hydraulic head) of the order of tens to hundreds of meters can results from 1 0 to 2 0 C temperature variations during shut-in (packer isolated) tests in low-permeability formations. Misinterpreted formation pressures and hydraulic conductivity can also result from inaccurate antecedent pressure history. Interpretation of representative formation properties and pressures requires that antecedent pressure information and test period temperature data be included as an integral part of the hydraulic test analyses

Site response assessment using borehole seismic records

Energy Technology Data Exchange (ETDEWEB)

Park, Donghee; Chang, Chunjoong; Choi, Weonhack [KHNP Central Research Institute, Daejeon (Korea, Republic of)

2014-05-15

In regions with high seismic activity, such as Japan, the Western United States and Taiwan, borehole seismometers installed deep underground are used to monitor seismic activity during the course of seismic wave propagation at various depths and to study the stress changes due to earthquakes and analyze the connection to fault movements. The Korea Meteorological Administration (KMA) and the Korea Institute of Geology and Mining (KIGAM) have installed and are operating borehole seismometers at a depth of 70∼100 meters for the precise determination of epicenters. Also, Korea Hydro and Nuclear Power Co., Ltd. (KHNP) has installed and is operating 2 borehole seismic stations near Weolseong area to observe at a depth of 140 meters seismic activities connected to fault activity. KHNP plans to operate in the second half of 2014 a borehole seismic station for depths less than 300 and 600 meters in order to study the seismic response characteristics in deep strata. As a basic study for analyzing ground motion response characteristics at depths of about 300 to 600 meters in connection with the deep geological disposal of spent nuclear fuel, the present study examined the background noise response characteristics of the borehole seismic station operated by KHNP. In order to analyze the depth-dependent impact of seismic waves at deeper depths than in Korea, seismic data collected by Japan's KIK-net seismic stations were used and the seismic wave characteristics analyzed by size and depth. In order to analyze the borehole seismic observation data from the seismic station operated by KHNP, this study analyzed the background noise characteristics by using a probability density function.

Site response assessment using borehole seismic records

International Nuclear Information System (INIS)

Park, Donghee; Chang, Chunjoong; Choi, Weonhack

2014-01-01

In regions with high seismic activity, such as Japan, the Western United States and Taiwan, borehole seismometers installed deep underground are used to monitor seismic activity during the course of seismic wave propagation at various depths and to study the stress changes due to earthquakes and analyze the connection to fault movements. The Korea Meteorological Administration (KMA) and the Korea Institute of Geology and Mining (KIGAM) have installed and are operating borehole seismometers at a depth of 70∼100 meters for the precise determination of epicenters. Also, Korea Hydro and Nuclear Power Co., Ltd. (KHNP) has installed and is operating 2 borehole seismic stations near Weolseong area to observe at a depth of 140 meters seismic activities connected to fault activity. KHNP plans to operate in the second half of 2014 a borehole seismic station for depths less than 300 and 600 meters in order to study the seismic response characteristics in deep strata. As a basic study for analyzing ground motion response characteristics at depths of about 300 to 600 meters in connection with the deep geological disposal of spent nuclear fuel, the present study examined the background noise response characteristics of the borehole seismic station operated by KHNP. In order to analyze the depth-dependent impact of seismic waves at deeper depths than in Korea, seismic data collected by Japan's KIK-net seismic stations were used and the seismic wave characteristics analyzed by size and depth. In order to analyze the borehole seismic observation data from the seismic station operated by KHNP, this study analyzed the background noise characteristics by using a probability density function

Borehole sealing. Final report, March 1, 1973--October 31, 1973

Energy Technology Data Exchange (ETDEWEB)

Eilers, L.H.

1977-01-01

A program to evaluate existing materials and techniques to permanently plug boreholes penetrating salt strata near prospective radioactive waste depository sites is described. A new subcontract No. 78X-33542C has been issued to seal a borehole near Lyons, Kansas, using the materials and techniques recommended in this report. It is recommended that the well be thoroughly cleaned including removing any casing penetrating the critical salt strata. Following this, any fluid-bearing zones should be grouted using the best grout available. Silica gel was recommended for porous zones backed up by Portland cement to seal fractures and vugs. Recommendations were made to use sulfate resistant Chem Comp or sulfate resistant regular Portland (Type V) as the primary sealing material in the areas where anhydrite strata are present such as the existing wells at Lyons, Kansas, or the prospective wells near Carlsbad, New Mexico. This would be modified to meet existing conditions such as salt saturated slurry through the salt strata or added powdered silica in the zones which might exceed 230/sup 0/F at any time. A short epoxy plug was recommended at the top and bottom of the salt strata and a short Seal Ring plug at the base of any extensive water zones. Extensive water zones are not expected in the New Mexico area, however.

Sedimentary and faunal sequence of the Wadhurst clay Wealden in boreholes at Wadhurst Park, Sussex

Energy Technology Data Exchange (ETDEWEB)

Anderson, F W; Bazley, R A.B.; Shephard-Thorn, E R

1967-01-01

Three boreholes sunk at Wadhurst Park, Sussex, provide a virtually complete section through the Wadhurst Clay (Wealden, Lower Cretaceous) in its type area. Full lithological logs of the boreholes with discussions of rock types, sedimentary features and depositional environments are given. It is suggested the sediments were deposited under shallow-water lagoonal conditions which varied from fresh-water to brackish and possibly marine. The succession of ostracod assemblages as found in the boreholes is recorded and compared with that found in the Warlingham (Surrey), Chilcombe Down No. 1 (Hampshire) and Kingsclere No. 1 (Hampshire) boreholes. Ostracods including a number of new species and subspecies, all belonging to the genus Cypridea, are described together with notes on the morphology of that genus. (22 refs.)

Search for Lepton Flavour Violation in ep Collisions at HERA

CERN Document Server

Aktas, A.; Andreev, V.; Anthonis, T.; Antunovic, B.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Backovic, S.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Beckingham, M.; Begzsuren, K.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, N.; Bizot, J.C.; Boenig, M.-O.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Busser, F.W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J.G.; Coughlan, J.A.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Daum, K.; de Boer, Y.; Delcourt, B.; Del Degan, M.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, Guenter; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eliseev, A.; Elsen, E.; Essenov, S.; Falkewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Finke, L.; Fleischer, M.; Fomenko, A.; Franke, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Ghazaryan, Samvel; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Gregori, M.; Grell, B.R.; Grindhammer, G.; Habib, S.; Haidt, D.; Hansson, M.; Heinzelmann, G.; Helebrant, C.; Henderson, R.C.W.; Henschel, H.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Hussain, S.; Jacquet, M.; Janssen, M.E.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I.R.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Landon, M.P.J.; Lange, W.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martisikova, M.; Martyn, H.-U.; Maxfield, S.J.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Mladenov, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Muller, K.; Murin, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G.D.; Peng, H.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Placakyte, R.; Povh, B.; Preda, T.; Prideaux, P.; Rahmat, A.J.; Raicevic, N.; Ravdandorj, T.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Sloan, T.; Smiljanic, Ivan; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, Arnd E.; Steder, M.; Stella, B.; Stiewe, J.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P.D.; Toll, T.; Tomasz, F.; Traynor, D.; Trinh, T.N.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, K.; Usik, A.; Utkin, D.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Trevino, A.Vargas; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; Wacker, K.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Wessels, M.; Wissing, Ch.; Wolf, R.; Wunsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y.C.; Zimmermann, J.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2007-01-01

A search for the lepton flavour violating processes ep->mu X and ep -> tau X is performed with the H1 experiment at HERA. Final states with a muon or tau and a hadronic jet are searched for in a data sample corresponding to an integrated luminosity of 66.5 pb-1 for e^+ p collisions and 13.7 pb^-1 for e^- p collisions at a centre-of-mass energy of 319 GeV. No evidence for lepton flavour violation is found. Limits are derived on the mass and the couplings of leptoquarks inducing lepton flavour violation in an extension of the Buchm"uller-R"uckl-Wyler effective model. Leptoquarks produced in ep collisions with a coupling strength of lambda=0.3 and decaying with the same coupling strength to a muon-quark pair or a tau-quark pair are excluded at 95% confidence level up to masses of 459 GeV and 379 GeV, respectively.

Search for lepton flavour violation in ep collisions at HERA

Energy Technology Data Exchange (ETDEWEB)

Aktas, A. [DESY, Hamburg (Germany); Alexa, C. [DESY, Hamburg (Germany)]|[National Institute for Physics and Nuclear Engineering, Magurele, Bucharest (Romania); Andreev, V. [Lebedev Physical Institute, Moscow (RU)] (and others)

2007-02-15

A search for the lepton flavour violating processes ep{yields}{mu}X and ep{yields}{tau}X is performed with the H1 experiment at HERA. Final states with a muon or tau and a hadronic jet are searched for in a data sample corresponding to an integrated luminosity of 66.5 pb{sup -1} for e{sup +}p collisions and 13.7 pb{sup -1} for e{sup -}p collisions at a centre-of-mass energy of 319 GeV. No evidence for lepton flavour violation is found. Limits are derived on the mass and the couplings of leptoquarks inducing lepton flavour violation in an extension of the Buchmueller-Rueckl-Wyler effective model. Leptoquarks produced in ep collisions with a coupling strength of {lambda}=0.3 and decaying with the same coupling strength to a muon-quark pair or a tau-quark pair are excluded at 95% confidence level up to masses of 459 GeV and 379 GeV, respectively. (orig.)

Search for lepton flavour violation in ep collisions at HERA

Science.gov (United States)

Aktas, A.; Alexa, C.; Andreev, V.; Anthonis, T.; Antunovic, B.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Beckingham, M.; Begzsuren, K.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Büsser, F. W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Cantun Avila, K. B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J. G.; Coughlan, J. A.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Daum, K.; de Boer, Y.; Delcourt, B.; Del Degan, M.; de Roeck, A.; de Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Eliseev, A.; Elsen, E.; Essenov, S.; Falkewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Finke, L.; Fleischer, M.; Fomenko, A.; Franke, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Ghazaryan, S.; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Gregori, M.; Grell, B. R.; Grindhammer, G.; Habib, S.; Haidt, D.; Hansson, M.; Heinzelmann, G.; Helebrant, C.; Henderson, R. C. W.; Henschel, H.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Hussain, S.; Jacquet, M.; Janssen, M. E.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, A. W.; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Landon, M. P. J.; Lange, W.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, L.; Martisikova, M.; Martyn, H.-U.; Maxfield, S. J.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Mladenov, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, T.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, T.; Pascaud, C.; Patel, G. D.; Peng, H.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Plačakytė, R.; Povh, B.; Preda, T.; Prideaux, P.; Rahmat, A. J.; Raicevic, N.; Ravdandorj, T.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D. P. C.; Sauter, M.; Sauvan, E.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R. N.; Sheviakov, I.; Shtarkov, L. N.; Sloan, T.; Smiljanic, I.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, A.; Steder, M.; Stella, B.; Stiewe, J.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Toll, T.; Tomasz, F.; Traynor, D.; Trinh, T. N.; Truöl, P.; Tsakov, I.; Tseepeldorj, B.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, K.; Usik, A.; Utkin, D.; Valkárová, A.; Vallée, C.; van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; Wacker, K.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Wessels, M.; Wissing, C.; Wolf, R.; Wünsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y. C.; Zimmermann, J.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2007-12-01

A search for the lepton flavour violating processes ep→μX and ep→τX is performed with the H1 experiment at HERA. Final states with a muon or tau and a hadronic jet are searched for in a data sample corresponding to an integrated luminosity of 66.5 pb-1 for e+p collisions and 13.7 pb-1 for e-p collisions at a centre-of-mass energy of 319 GeV. No evidence for lepton flavour violation is found. Limits are derived on the mass and the couplings of leptoquarks inducing lepton flavour violation in an extension of the Buchmüller Rückl Wyler effective model. Leptoquarks produced in ep collisions with a coupling strength of λ=0.3 and decaying with the same coupling strength to a muon quark pair or a tau quark pair are excluded at 95% confidence level up to masses of 459 GeV and 379 GeV, respectively.

Geophysical logging of the Harwell boreholes

International Nuclear Information System (INIS)

Brightman, M.A.

1983-08-01

A comprehensive geophysical borehole logging survey was carried out on each of three deep boreholes drilled at the Harwell research site. KOALA and PETRA computer programs were used to analyse and interpret the logs to obtain continuous quantitative estimates of the geological and hydrogeological properties of the sequences penetrated at the Harwell site. Quantitative estimates of the mineral composition and porosity of the cores samples were made. (UK)

The Influence of Ice Properties on Borehole Deformation at the West Antarctic Ice Sheet Divide

Science.gov (United States)

Sinkler, E.; Pettit, E. C.; Obbard, R. W.

2017-12-01

It is widely known that ice flow is affected by many properties, including crystal fabric and impurities, though these relationships are not fully understood. This study uses data from the West Antarctic Ice Sheet (WAIS) Divide borehole to better determine the influence of such properties on ice flow. The WAIS Divide borehole, the byproduct of the 2006-2012 coring project, offers a unique opportunity to study deep Antarctic Ice. Thanks to the work of many researchers, extensive data on ice properties are available from both coring and borehole logging at this site. The borehole, kept open with a density-approximating fluid, closes and tilts due to ice flow. We have tracked this deformation over two years using a set of repeat measurements with an Acoustic Televiewer. This tool acts as an acoustic caliper allowing us to view cross-sections of the borehole shape and size with up to 1.25 degree azimuthal resolution and a depth resolution as high as 1.4 mm. In addition, the tool collects tilt and azimuth data. These measurements are compared to a 1D Glen's Flow Law model for borehole closure that uses density differences between the ice and borehole fluid as its driving force and incorporates temperature effects. This is then compared to ice properties like crystal fabric and impurities in order to determine the influence of these properties on ice deformation at this site. Crystal fabric has appeared as an important factor in this study.This work builds on that of others who have studied in-situ deep ice through borehole deformation (e.g. Paterson, 1977 and Dahl-Jensen and Gundestrup, 1987). Our results have implications for ice flow modeling and therefore interpretation of depth-age relationships in deep ice cores.

Structures and Logic of EP Implementation and Administration in China

Directory of Open Access Journals (Sweden)

Dieter Grunow

2011-01-01

Full Text Available This paper describes empirical observations gathered during a research project on the implementation of environmental protection (EP policies in China. The project focused on local EP in both urban and rural areas. Policy field analysis was used as a conceptual framework for structuring the observations. The paper develops in three main steps discussing the following topics: 1 Collective problems within the policy field of EP show that EP issues in general are unlike those of other policy fields. Official EP policies in China today resemble those of other countries – but they are separating issues and responsibilities, making local implementation very demanding. 2 China lags behind in its willingness and ability to implement these policies – leading to implementation gaps. To explore the causes and consequences, specific sites in China are described in an extended look at local implementation structures. It was found that although policies in China are basically the same everywhere, the structures for implementing them and the quality of their implementation vary widely with regard to resources, organization, coordination, staff qualifications, personnel placement, and other aspects. 3 Not all of the challenges hampering local implementation of environmental policies were China-specific; however, some of those which are can be described as the macro-context: an ineffective rule of law, insufficient involvement of civil society, and complicated macro-structures of public administration prevent a generally high level of successful EP implementation in China.

Drilling, logging, and testing information from borehole UE-25 UZ number-sign 16, Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Thamir, F.; Thordarson, W.; Kume, J.; Rousseau, J.; Cunningham, D.M. Jr.

1998-01-01

Borehole UE-25 UZ number-sign 16 is the first of two boreholes that may be used to determine the subsurface structure at Yucca Mountain by using vertical seismic profiling. This report contains information collected while this borehole was being drilled, logged, and tested from May 27, 1992, to April 22, 1994. It does not contain the vertical seismic profiling data. This report is intended to be used as: (1) a reference for drilling similar boreholes in the same area, (2) a data source on this borehole, and (3) a reference for other information that is available from this borehole. The reference information includes drilling chronology, equipment, parameters, coring methods, penetration rates, completion information, drilling problems, and corrective actions. The data sources include lithology, fracture logs, a list of available borehole logs, and depths at which water was recorded. Other information is listed in an appendix that includes studies done after April 22, 1994

Knowledge, Practices, and Barriers to HIV Pre-Exposure Prophylaxis (PrEP) Prescribing Among Washington State Medical Providers.

Science.gov (United States)

Wood, Brian R; McMahan, Vanessa M; Naismith, Kelly; Stockton, Jonathan B; Delaney, Lori A; Stekler, Joanne D

2018-01-04

We aimed to assess HIV pre-exposure prophylaxis (PrEP) awareness and prescribing practices among Washington State medical providers from diverse professional disciplines and practice types. In May 2016, we administered an anonymous online survey to licensed medical practitioners who provide primary, longitudinal, walk-in, emergency, obstetric, gynecologic, sexually transmitted infection (STI), or family planning care. Of 735 eligible providers, 64.8% had heard of PrEP. Younger providers and providers with a Doctor of Medicine (MD) degree were more likely to be aware of PrEP compared to older providers (p=0.0001) and providers of other training backgrounds (Advanced Registered Nurse Practitioner [ARNP], Doctor of Osteopathic Medicine [DO], or Physician Assistant [PA]) (p=0.04). Among providers aware of PrEP, most frequent reported concerns about prescribing were adherence (46.0%) and costs (42.9%). Providers felt very (20.1%) or somewhat (33.8%) comfortable discussing PrEP overall, but very (26.8%) or somewhat (44.7%) uncomfortable discussing cost and insurance issues. The 124 PrEP prescribers reported a median of 2 (range 1-175, total 1,142) patients prescribed PrEP. Prior authorizations and insurance denials had prevented prescriptions for 28.7% and 12.1% of prescribers, respectively. Interventions to improve PrEP access should include education to inform medical providers about PrEP, with particular attention to provider types less likely to be aware. Continued efforts to eliminate cost and insurance barriers and educate providers regarding financial resources would help improve PrEP access.

comparison of performance of public and private boreholes

African Journals Online (AJOL)

User

comparison of the performance of three categories of boreholes namely: public operated boreholes ... Port Harcourt in River State of Nigeria is a fast developing state. ..... World. Bank. Dujam, Consultants (1988). Nation-wide water. Supply and.

Core drilling of deep borehole OL-KR46 at Olkiluoto in Eurajoki 2007

International Nuclear Information System (INIS)

Toropainen, V.

2007-09-01

granite. The average fracture frequency is 1.2 pcs/m in borehole OL-KR46 and 3.6 pcs/m in borehole OL-KR46B. The average RQD values were 98.3 % and 93.1 %. In borehole OL-KR46 eight fractured zones and in borehole OL-KR46B three fractured zones were penetrated during drilling work. (orig.)

Highlights from e-EPS: Hetland to receive EPS-PED Award for Secondary School Teaching

CERN Multimedia

Urbaan Titulaer

2013-01-01

e-EPS News is an addition to the CERN Bulletin line-up, showcasing articles from e-EPS – the European Physical Society newsletter – as part of a collaboration between the two publications.   The EPS Physics Education Division selected Karl Thorstein Hetland, West Telemark Secondary School, Norway, as this year’s recipient of its Secondary School Teaching Award. K.T. Hetland developed the Energy Network, which aims to make students energy conscious and focus on renewable energy. The Energy Network, created in 2005, consists of 15 local networks, each involving an upper secondary school and several lower secondary schools, 55 schools in all. Material from the Network is used in physics classes in a large number of schools at national level and plays a major role in recruiting university physics students. K.T. Hetland will receive his award at the International Physics Education Conference, held together with the European Physics Educati...

Repeated temperature logs from Czech, Slovenian and Portuguese borehole climate observatories

Czech Academy of Sciences Publication Activity Database

Šafanda, Jan; Rajver, D.; Correia, A.; Dědeček, Petr

2007-01-01

Roč. 3, č. 3 (2007), s. 453-462 ISSN 1814-9324 R&D Projects: GA AV ČR(CZ) IAA300120603 Grant - others:NATO(US) PDD(CP)-(EST.CLG 980 152) Institutional research plan: CEZ:AV0Z30120515 Source of funding: V - iné verejné zdroje Keywords : borehole temperatures * temperature logs * borehole climate observatories Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 1.450, year: 2007

An ep collider with Ecm = 1 TeV in a VLHC booster tunnel

International Nuclear Information System (INIS)

Barber, D. P.; Chojnacki, E.; Derrick, M.; Friedsam, H.; Gorski, A.; Hanuska, S.; Jagger, J.; Krakauer, D.; Norem, J.; Rotela, E.; Sen, T.; Sharma, S.; Teng, L.; Thompson, K.

1999-01-01

The low field option for the VLHC includes a 3 TeV proton booster with a circumference of 34 km. The authors are studying the option of an electron ring to fit in this tunnel which can produce ep collisions with a luminosity of 1 fb -1 /yr with a center of mass energy of 1 TeV. The machine would utilize superconducting rf and small low field magnets for the approximately 80 GeV electron beam. They describe the vacuum chamber/magnet system, rf power supply requirements, vacuum chamber cooling, interaction regions and installation of the facility in the tunnel, as well as provide preliminary estimates of beam stability and lifetimes

Immobilized low-activity waste site borehole 299-E17-21

International Nuclear Information System (INIS)

Reidel, S.P.; Reynolds, K.D.; Horton, D.G.

1998-08-01

The Tank Waste Remediation System (TWRS) is the group at the Hanford Site responsible for the safe underground storage of liquid waste from previous Hanford Site operations, the storage and disposal of immobilized tank waste, and closure of underground tanks. The current plan is to dispose of immobilized low-activity tank waste (ILAW) in new facilities in the southcentral part of 200-East Area and in four existing vaults along the east side of 200-East Area. Boreholes 299-E17-21, B8501, and B8502 were drilled at the southwest corner of the ILAW site in support of the Performance Assessment activities for the disposal options. This report summarizes the initial geologic findings, field tests conducted on those boreholes, and ongoing studies. One deep (480 feet) borehole and two shallow (50 feet) boreholes were drilled at the southwest corner of the ILAW site. The primary factor dictating the location of the boreholes was their characterization function with respect to developing the geohydrologic model for the site and satisfying associated Data Quality Objectives. The deep borehole was drilled to characterize subsurface conditions beneath the ILAW site, and two shallow boreholes were drilled to support an ongoing environmental tracer study. The tracer study will supply information to the Performance Assessment. All the boreholes provide data on the vadose zone and saturated zone in a previously uncharacterized area

Site Characterization Data from the U3ax/bl Exploratory Boreholes at the Nevada Test Site

International Nuclear Information System (INIS)

2005-01-01

This report provides qualitative analyses and preliminary interpretations of hydrogeologic data obtained from two 45-degree, slanted exploratory boreholes drilled within the Area 3 Radioactive Waste Management Site (RWMS) at the Nevada Test Site. Borehole UE-3bl-D1 was drilled beneath the U3ax/bl mixed waste disposal unit, and Borehole UE-3bl-U1 was drilled in undisturbed alluvium adjacent to the disposal unit. The U3ax/bl disposal unit is located within two conjoined subsidence craters, U3ax and U3bl, which were created by underground nuclear testing. Data from these boreholes were collected to support site characterization activities for the U3ax/bl disposal unit and the entire Area 3 RWMS. Site characterization at disposal units within the Area 3 RWMS must address the possibility that subsidence craters and associated disturbed alluvium of the chimneys beneath the craters might serve as pathways for contaminant migration. The two boreholes were drilled and sampled to compare hydrogeologic properties of alluvium below the waste disposal unit with those of adjacent undisturbed alluvium. Whether Borehole UE-3bl-D1 actually penetrated the chimney of the U3bl crater is uncertain. Analyses of core samples showed little difference in hydrogeologic properties between the two boreholes. Important findings of this study include the following: No hazardous or radioactive constituents of waste disposal concern were found in the samples obtained from either borehole. No significant differences in physical and hydrogeologic properties between boreholes is evident, and no evidence of significant trends with depth for any of these properties was observed. The values observed are typical of sandy materials. The alluvium is dry, with volumetric water content ranging from 5.6 to 16.2 percent. Both boreholes exhibit a slight increase in water content with depth, the only such trend observed. Water potential measurements on core samples from both boreholes show a large positive

Site Characterization Data from the U3ax/bl Exploratory Boreholes at the Nevada Test Site

Energy Technology Data Exchange (ETDEWEB)

Bechtel Nevada; U.S. Department of Energy, National Nuclear Security Administration Nevada Site Office

2005-08-01

This report provides qualitative analyses and preliminary interpretations of hydrogeologic data obtained from two 45-degree, slanted exploratory boreholes drilled within the Area 3 Radioactive Waste Management Site (RWMS) at the Nevada Test Site. Borehole UE-3bl-D1 was drilled beneath the U3ax/bl mixed waste disposal unit, and Borehole UE-3bl-U1 was drilled in undisturbed alluvium adjacent to the disposal unit. The U3ax/bl disposal unit is located within two conjoined subsidence craters, U3ax and U3bl, which were created by underground nuclear testing. Data from these boreholes were collected to support site characterization activities for the U3ax/bl disposal unit and the entire Area 3 RWMS. Site characterization at disposal units within the Area 3 RWMS must address the possibility that subsidence craters and associated disturbed alluvium of the chimneys beneath the craters might serve as pathways for contaminant migration. The two boreholes were drilled and sampled to compare hydrogeologic properties of alluvium below the waste disposal unit with those of adjacent undisturbed alluvium. Whether Borehole UE-3bl-D1 actually penetrated the chimney of the U3bl crater is uncertain. Analyses of core samples showed little difference in hydrogeologic properties between the two boreholes. Important findings of this study include the following: No hazardous or radioactive constituents of waste disposal concern were found in the samples obtained from either borehole. No significant differences in physical and hydrogeologic properties between boreholes is evident, and no evidence of significant trends with depth for any of these properties was observed. The values observed are typical of sandy materials. The alluvium is dry, with volumetric water content ranging from 5.6 to 16.2 percent. Both boreholes exhibit a slight increase in water content with depth, the only such trend observed. Water potential measurements on core samples from both boreholes show a large positive

Phase correction of electromagnetic coupling effects in cross-borehole EIT measurements

International Nuclear Information System (INIS)

Zhao, Y; Zimmermann, E; Wolters, B; Van Waasen, S; Huisman, J A; Treichel, A; Kemna, A

2015-01-01

Borehole EIT measurements in a broad frequency range (mHz to kHz) are used to study subsurface geophysical properties. However, accurate measurements have long been difficult because the required long electric cables introduce undesired inductive and capacitive coupling effects. Recently, it has been shown that such effects can successfully be corrected in the case of single-borehole measurements. The aim of this paper is to extend the previously developed correction procedure for inductive coupling during EIT measurements in a single borehole to cross-borehole EIT measurements with multiple borehole electrode chains. In order to accelerate and simplify the previously developed correction procedure for inductive coupling, a pole–pole matrix of mutual inductances is defined. This consists of the inductances of each individual chain obtained from calibration measurements and the inductances between two chains calculated from the known cable positions using numerical modelling. The new correction procedure is successfully verified with measurements in a water-filled pool under controlled conditions where the errors introduced by capacitive coupling were well-defined and could be estimated by FEM forward modelling. In addition, EIT field measurements demonstrate that the correction methods increase the phase accuracy considerably. Overall, the phase accuracy of cross-hole EIT measurements after correction of inductive and capacitive coupling is improved to better than 1 mrad up to a frequency of 1 kHz, which substantially improves our ability to characterize the frequency-dependent complex electrical resistivity of weakly polarizable soils and sediments in situ. (paper)

Scientific results from the deepened Lopra-1 borehole, Faroe Islands: Borehole seismic studies of a volcanic succession from the Lopra-1/1A borehole in the Faroe Islands, northern North Atlantic

Directory of Open Access Journals (Sweden)

Cowper, David

2006-07-01

Full Text Available Extruded basalt flows overlying sedimentary sequences present a challenge to hydrocarbon exploration using reflection seismic techniques. The Lopra-1/1A re-entry well on the Faroese island of Suðuroy allowed us to study the seismic characteristics of a thick sequence of basalt flows from well logs and borehole seismic recordings. Data acquired during the deepening operation in 1996 are presented here.The re-entry well found that the seismic event at 2340 m, prognosed from the pre-drill Vertical Seismic Profile (VSP as a decrease in impedance, was not base basalt and the deepened well remainedwithin the lower series basalts. Nonetheless, compressional and shear sonic logs and a density log were recorded over the full open hole interval. These allowed a firm tie to be made with the reflectedwavefield from a new VSP. The sonic logs show a compressional to shear wavespeed ratio of 1.84 which is almost constant with depth. Sonic compressional wavespeeds are 3% higher than seismicvelocities, suggesting dispersion in the basalt flows. Azimuthal anisotropy was weakly indicated by the shear sonic log but its orientation is consistent with the directions of mapped master joints in the vicinity of the well.The VSP downgoing compressional wavelet shows good persistence, retaining a dominant period of 28 ms at 3510 m depth. Average vertical velocity is 5248 m/s, higher than previously reported.Attenuation can largely be modelled by geometrical spreading and scattering loss, consistent with other studies. Within the piled flows, the effective Q from scattering is about 35. Elastic layeredmedium modelling shows some hope that a mode-converted shear wave may be observed at moderate offsets. Like its predecessor, the 1996 VSP indicates a decrease in impedance below the final depth ofthe well. However, it is unlikely to be basement or sediment and is probably an event within the volcanic sequence.

A newly developed borehole flowmeter technology for heterogeneous aquifers

International Nuclear Information System (INIS)

Young, S.C.

1990-01-01

Extensive borehole flowmeter tests were performed at 37 fully-screened wells on a one-hectare test site to characterize the three-dimensional hydraulic conductivity field of an alluvial aquifer with a σ lnK of 4.7. During the site investigations, several major advancements with respect to borehole flowmeter technology were developed. The milestones included: (1) the development of a field-durable electromagnetic borehole flowmeter with a lower detection limit of 0.1 l/min; (2) the realization of the importance of the pumping rate with respect to the calculated value for the depth-averaged hydraulic conductivity; and (3) an evaluation of alternative methods for calculating the depth-averaged hydraulic conductivity. The predicted three-dimensional hydraulic conductivity field was compared to the results of 10 small-scale (3 to 7 m) tracer tests, information about the depositional history of the aquifer, and the results of three large-scale aquifer tests. The hydraulic conductivity data predict the major features of the tracer breakthrough curves, maps the outline of a former river meander in an aerial photograph, and leads to a geometric mean consistent with the average hydraulic conductivity of the aquifer. (Author) (14 refs., 15 figs., 2 tabs.)

Deep Borehole Field Test Conceptual Design Report

Energy Technology Data Exchange (ETDEWEB)

Hardin, Ernest L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2016-09-30

This report documents conceptual design development for the Deep Borehole Field Test (DBFT), including test packages (simulated waste packages, not containing waste) and a system for demonstrating emplacement and retrieval of those packages in the planned Field Test Borehole (FTB). For the DBFT to have demonstration value, it must be based on conceptualization of a deep borehole disposal (DBD) system. This document therefore identifies key options for a DBD system, describes an updated reference DBD concept, and derives a recommended concept for the DBFT demonstration. The objective of the DBFT is to confirm the safety and feasibility of the DBD concept for long-term isolation of radioactive waste. The conceptual design described in this report will demonstrate equipment and operations for safe waste handling and downhole emplacement of test packages, while contributing to an evaluation of the overall safety and practicality of the DBD concept. The DBFT also includes drilling and downhole characterization investigations that are described elsewhere (see Section 1). Importantly, no radioactive waste will be used in the DBFT, nor will the DBFT site be used for disposal of any type of waste. The foremost performance objective for conduct of the DBFT is to demonstrate safe operations in all aspects of the test.

Adhesion strength and spreading characteristics of EPS on membrane surfaces during lateral and central growth.

Science.gov (United States)

Tansel, Berrin; Tansel, Derya Z

2013-11-01

Deposition of extracellular polymeric substances (EPS) on membrane surfaces is a precursor step for bacterial attachment. The purpose of this study was to analyze the morphological changes on a clean polysulfone ultrafilration membrane after exposure to effluent from a membrane bioreactor. The effluent was filtered to remove bacteria before exposing the membrane. The morphological characterization was performed by atomic force microscopy (AFM). The lateral (2D) and central growth characteristics (3D) of the EPS deposits were evaluated by section and topographical analyses of the height images. The contact angle of single EPS units was 9.07 ± 0.50° which increased to 24.41 ± 1.00° for large clusters (over 10 units) and decreased to 18.68 ± 1.00° for the multilayered clusters. The surface tension of the single EPS units was 49.34 ± 1.70 mNm(-1). The surface tension of single layered small and large EPS clusters were 51.26 ± 2.05 and 53.48 ± 2.01 mNm(-1), respectively. For the multilayered clusters, the surface tension was 51.43 ± 2.05 mNm(-1). The spreading values were negative for all deposits on the polysulfone membrane indicating that the EPS clusters did not have tendency to spread but preferred to retain their shapes. Copyright © 2013 Elsevier B.V. All rights reserved.

Site Characterization Of Borehole Disposal Facility (BOSS)

International Nuclear Information System (INIS)

Kamarudin Samuding; Mohd Abd Wahab Yusof; Mohd Muzamil; Nazran Harun; Nurul Fairuz Diyana Bahrudin; Ismail, C. Mohamad; Kalam

2014-01-01

Site characterization study is one of the major components in assessing the potential site for borehole disposal facility. The main objectives of this study are to obtain the geology, geomorphology, hydrogeology and geochemistry information in order to understand the regional geological setting, its past evolution and likely future natural evolution over the assessment time frame. This study was focused on the geological information, borehole log and hydrogeological information. Geological information involve general geology, lineament, topography, structure geology, geological terrain. Whereas Borehole log information consists of lithology, soil and rock formation, gamma logging data and physical properties of soil and rock. Hydrogeological information was emphasized on the groundwater flow, physical parameter as well as geochemical data. Geological mapping shows the study area is underlain by metamorphic rock of the Kenny Hill Formation. Lithologically, it composed of psammitic schist of sandstone origin and phyllite. Based on the borehole log profile, the study area is covered by thick layer of residual soil and estimated not less than 10 m. Those foliated rocks tend to break or split along the foliation planes. The foliation or schistosity may also serve as conduit for groundwater migration. Main structural geology features in the study area trend predominantly in North to Northeast directions. Major fault, the UKM Fault trends in NE-SW direction about 0.5 km located to the east of the proposed borehole site. The groundwater flow direction is influenced by the structure and bedding of the rock formation. Whereas the groundwater flow velocity in the borehole ranges 2.15 - 5.24 x 10 -4 m/ sec. All the data that are obtained in this study is used to support the Safety Assessment and Safety Case report. (author)

76 FR 52952 - Student Services Contract EP-11-D-000403 Yin Gu; Transfer of Data

Science.gov (United States)

2011-08-24

... will enable Student Services Contract EP-11-D-000403 Yin Gu to fulfill the obligations of the contract... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OPP-2011-0038; FRL-8884-1] Student Services Contract EP-11... Business Information (CBI) by the submitter, will be transferred to Student Services Contract EP- 11-D...

Developments of borehole strain observation outside China

Institute of Scientific and Technical Information of China (English)

邱泽华; 石耀霖

2004-01-01

Borehole strain observation is playing an increasingly important role in the study on the crustal movements. It hasbeen used by many countries such as China, USA, Japan, Peru, Australia, South Africa, Iceland and Italy, in research fields of plate tectonics, earthquake, volcanic eruption, dam safety, oil field subsidence, mining collapse andso on. Borehole strainmeter has been improved rapidly and tends to get more and more components included inone probe. Based on observations by this kind of instruments, studies on seismic strain step, slow earthquake,earthquake precursor and volcanic eruption forecasting have made remarkable achievements. In the coming years,borehole strain observation is going to become one major geodetic means, together with GPS and InSAR.

Search for Leptoquark Bosons in ep Collisions at HERA

CERN Document Server

Aktas, A.; Anthonis, T.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Bahr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J.C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D.P.; Bruncko, D.; Busser, F.W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Contreras, J.G.; Coughlan, J.A.; Cox, B.E.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Dau, W.D.; Daum, K.; de Boer, Y.; Delcourt, B.; De Roeck, A.; Desch, K.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, Guenter; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Falkewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y.H.; Flucke, G.; Fomenko, A.; Foresti, I.; Franke, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerlich, C.; Ghazaryan, Samvel; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grell, B.R.; Grindhammer, Guenter; Gwilliam, C.; Haidt, D.; Hajduk, L.; Hansson, M.; Heinzelmann, G.; Henderson, R.C.W.; Henschel, H.; Henshaw, O.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Keller, N.; Kenyon, I.R.; Kiesling, Christian M.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kuckens, J.; Landon, M.P.J.; Lange, W.; Lastovicka, T.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Leiner, B.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; Liptaj, A.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Luke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxeld, S.J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mladenov, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Muller, K.; Murin, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Papadopoulou, T.; Pascaud, C.; Patel, G.D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Placakyte, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D.P.C.; Sauvan, E.; Schatzel, S.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schroder, V.; Schultz-Coulon, H.-C.; Sedlak, K.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, Arnd E.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, Graham; Thompson, P.D.; Tomasz, F.; Traynor, D.; Truoel, Peter; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, Marcel; Usik, A.; Utkin, D.; Valkar, S.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Wissing, Ch.; Wolf, R.; Wunsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y.C.; Zimmermann, J.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2005-01-01

A search for scalar and vector leptoquarks coupling to first generation fermions is performed using the e^+p and e^-p scattering data collected by the H1 experiment between 1994 and 2000. The data correspond to a total integrated luminosity of 117 pb^{-1}. No evidence for the direct or indirect production of such particles is found in data samples with a large transverse momentum final state electron or with large missing transverse momentum. Constraints on leptoquark models are established. For leptoquark couplings of electromagnetic strength, leptoquarks with masses up to 275-325 GeV are ruled out. These limits improve and supercede earlier H1 limits based on subsamples of the data used here.

A study of identified hadron fragmentation on eP collisions at HERA using the H1 detector

Energy Technology Data Exchange (ETDEWEB)

Turney, Jonathan Edward

2002-07-01

Deep inelastic scattering events from ep collisions, recorded in 1996 and 1997 by the H1 detector at HERA, are used to study the fragmentation properties of identified hadrons in the Breit frame of reference. A review of the theory relevant to this analysis is also presented, together with a description of the H1 detector. Using dE/dx information and neutral secondary particle invariant mass spectra, it is possible to identify samples of {pi}{sup {+-}}, K{sup {+-}}, protons and antiprotons, K{sub S}{sup 0}, and {lambda} hadrons in the Breit frame current hemisphere and measure corresponding exclusive fragmentation functions. The evolution of the fragmentation function peak position and width are studied as a function of hadronic mass and four-momentum transfer, Q. Comparison is made to published results from e{sup +}e{sup -} experiments, models of the hadronic final state, and to predictions from MLLA/LPHD theory. The fragmentation properties of identified hadrons in ep data compare well with those in e{sup +}e{sup -} data, giving further evidence for the universality of quark fragmentation. By applying a MLLA/LPHD calculation using parameters derived from fitting H1 data, it is possible to describe the peak evolution in e{sup +}e{sup -} data as a function of energy, hadronic mass, and the parton shower cut-off parameter, Q{sub 0}{sup h}. However, the MLLA/LPHD calculation is unable to describe the data fully, particularly the e{sup +}e{sup -} -derived width evolution. Furthermore, the Monte Carlo models of the hadronic final state are shown to be incompatible with the detailed parameterisation of MLLA/LPHD, but follow the observed trends in ep data well. (author)

A study of identified hadron fragmentation on eP collisions at HERA using the H1 detector

International Nuclear Information System (INIS)

Turney, Jonathan Edward

2002-01-01

Deep inelastic scattering events from ep collisions, recorded in 1996 and 1997 by the H1 detector at HERA, are used to study the fragmentation properties of identified hadrons in the Breit frame of reference. A review of the theory relevant to this analysis is also presented, together with a description of the H1 detector. Using dE/dx information and neutral secondary particle invariant mass spectra, it is possible to identify samples of π ± , K ± , protons and antiprotons, K S 0 , and Λ hadrons in the Breit frame current hemisphere and measure corresponding exclusive fragmentation functions. The evolution of the fragmentation function peak position and width are studied as a function of hadronic mass and four-momentum transfer, Q. Comparison is made to published results from e + e - experiments, models of the hadronic final state, and to predictions from MLLA/LPHD theory. The fragmentation properties of identified hadrons in ep data compare well with those in e + e - data, giving further evidence for the universality of quark fragmentation. By applying a MLLA/LPHD calculation using parameters derived from fitting H1 data, it is possible to describe the peak evolution in e + e - data as a function of energy, hadronic mass, and the parton shower cut-off parameter, Q 0 h . However, the MLLA/LPHD calculation is unable to describe the data fully, particularly the e + e - -derived width evolution. Furthermore, the Monte Carlo models of the hadronic final state are shown to be incompatible with the detailed parameterisation of MLLA/LPHD, but follow the observed trends in ep data well. (author)

Amplification Factors for Spectral Acceleration Using Borehole Seismic Array in Taiwan

Science.gov (United States)

Lai, T. S.; Yih-Min, W.; Chao, W. A.; Chang, C. H.

2017-12-01

In order to reduce the noise from surface to get the high-quality seismic recordings, there are 54 borehole seismic arrays have been installed in Taiwan deployed by Central Weather Bureau (CWB) until the end of 2016. Each array includes two force balance accelerometers, one at the surface and other inside the borehole, as well as one broadband seismometer inside the borehole. The downhole instruments are placed at a depth between 120 and 400 m. The background noise level are lower at the borehole stations, but the amplitudes recorded by borehole stations are smaller than surface stations for the same earthquake due to the different geology conditions. Therefore, the earthquake magnitude estimated by borehole station is smaller than surface station. So far, CWB only use the surface stations in the magnitude determination due to this situation. In this study, we investigate the site effects between surface and downhole for borehole seismic arrays. Using the spectral ratio derived by the two-station spectral method as the transfer function, simulated the waveform recorded by borehole stations to the surface stations. In the future, through the transfer function, the borehole stations will be included in the estimation of earthquake magnitude and the results of amplification factors can provide the information of near-surface site effects for the ground motion simulation applications.

The Device for Communication in the Tool for Measurement in Boreholes

Directory of Open Access Journals (Sweden)

Miloš Slankamenac

2005-10-01

Full Text Available In this paper an implementation and test of the device for communication between Telemetry system and Surface unit with the tool for measurement of pipe diameter, fluid velocity and direction of flow in the borehole (Calliper-Fullbore Flowmeter - CFF are presented. This communication is done according to SIPLOS (Simultaneous Production Logging String protocol and it is used by Hotwell company [1] as a part of a larger system for borehole investigations.

Bond strength of cementitious borehole plugs in welded tuff

International Nuclear Information System (INIS)

Akgun, H.; Daemen, J.J.K.

1991-02-01

Axial loads on plugs or seals in an underground repository due to gas, water pressures and temperature changes induced subsequent to waste and plug emplacement lead to shear stresses at the plug/rock contact. Therefore, the bond between the plug and rock is a critical element for the design and effectiveness of plugs in boreholes, shafts or tunnels. This study includes a systematic investigation of the bond strength of cementitious borehole plugs in welded tuff. Analytical and numerical analysis of borehole plug-rock stress transfer mechanics is performed. The interface strength and deformation are studied as a function of Young's modulus ratio of plug and rock, plug length and rock cylinder outside-to-inside radius ratio. The tensile stresses in and near an axially loaded plug are analyzed. The frictional interface strength of an axially loaded borehole plug, the effect of axial stress and lateral external stress, and thermal effects are also analyzed. Implications for plug design are discussed. The main conclusion is a strong recommendation to design friction plugs in shafts, drifts, tunnels or boreholes with a minimum length to diameter ratio of four. Such a geometrical design will reduce tensile stresses in the plug and in the host rock to a level which should minimize the risk of long-term deterioration caused by excessive tensile stresses. Push-out tests have been used to determine the bond strength by applying an axial load to cement plugs emplaced in boreholes in welded tuff cylinders. A total of 130 push-out tests have been performed as a function of borehole size, plug length, temperature, and degree of saturation of the host tuff. The use of four different borehole radii enables evaluation of size effects. 119 refs., 42 figs., 20 tabs

Utility service entrance in boreholes

International Nuclear Information System (INIS)

1987-08-01

This study evaluates alternatives for utility service entrances to the repository. We determined the requirements for a repository utility supply. These requirements were defined as safety, maintainability, flexibility, reliability, cost efficiency, voltage regulation, and simplicity of operation. The study showed that repository shafts can best satisfy all requirements for location of the utility supply without the use of borehole penetrations into the repository. It is recommended that the shafts be utilized for utility distribution to the repository, and that the current NWTS program position to minimize the number of boreholes penetrating the repository horizon be maintained. 42 refs., 2 figs., 3 tabs

Borehole sealing literature review of performance requirements and materials

International Nuclear Information System (INIS)

Piccinin, D.; Hooton, R.D.

1985-02-01

To ensure the safe disposal of nuclear wastes, all potential pathways for radionuclide release to the biosphere must be effectively sealed. This report presents a summary of the literature up to August 1982 and outlines the placement, mechanical property and durability-stability requirements for borehole sealing. An outline of the materials that have been considered for possible use in borehole sealing is also included. Cement grouts are recommended for further study since it is indicated in the literature that cement grouts offer the best opportunity of effectively sealing boreholes employing present technology. However, new and less well known materials should also be researched to ensure that the best possible borehole plugging system is developed. 78 refs

Rock stress orientation measurements using induced thermal spalling in slim boreholes

International Nuclear Information System (INIS)

Hakami, Eva

2011-05-01

In the planning and design of a future underground storage for nuclear waste based on the KBS-3 method, one of the aims is to optimize the layout of deposition tunnels such that the rock stresses on the boundaries of deposition holes are minimized. Previous experiences from heating of larger scale boreholes at the Aespoe Hard Rock Laboratory (AHRL) gave rise to the idea that induced borehole breakouts using thermal loading in smaller diameter boreholes, could be a possible way of determining the stress orientation. Two pilot experiments were performed, one at the Aespoe Hard Rock Laboratory and one at ONKALO research site in Finland. An acoustic televiewer logger was used to measure the detailed geometrical condition of the borehole before and after heating periods. The acoustic televiewer gives a value for each 0.7 mm large pixel size around the borehole periphery. The results from the loggers are presented as images of the borehole wall, and as curves for the maximum, mean and minimum values at each depth. Any changes in the borehole wall geometry may thus be easily detected by comparisons of the logging result images. In addition, using an optical borehole televiewer a good and detailed realistic colour picture of the borehole wall is obtained. From these images the character of the spalls identified may be evaluated further. The heating was performed in a 4 m long section, using a heating cable centred in an 8 m deep vertical borehole, drilled from the floor of the tunnels. For the borehole in the Q-tunnel of AHRL the results from the loggings of the borehole before the heating revealed that breakouts existed even before this pilot test due to previous heating experiments at the site (CAPS). Quite consistent orientation and the typical shape of small breakouts were observed. After the heating the spalling increased slightly at the same locations and a new spalling location also developed at a deeper location in the borehole. At ONKALO three very small changes

Rock stress orientation measurements using induced thermal spalling in slim boreholes

Energy Technology Data Exchange (ETDEWEB)

Hakami, Eva [Geosigma AB, Uppsala (Sweden)

2011-05-15

In the planning and design of a future underground storage for nuclear waste based on the KBS-3 method, one of the aims is to optimize the layout of deposition tunnels such that the rock stresses on the boundaries of deposition holes are minimized. Previous experiences from heating of larger scale boreholes at the Aespoe Hard Rock Laboratory (AHRL) gave rise to the idea that induced borehole breakouts using thermal loading in smaller diameter boreholes, could be a possible way of determining the stress orientation. Two pilot experiments were performed, one at the Aespoe Hard Rock Laboratory and one at ONKALO research site in Finland. An acoustic televiewer logger was used to measure the detailed geometrical condition of the borehole before and after heating periods. The acoustic televiewer gives a value for each 0.7 mm large pixel size around the borehole periphery. The results from the loggers are presented as images of the borehole wall, and as curves for the maximum, mean and minimum values at each depth. Any changes in the borehole wall geometry may thus be easily detected by comparisons of the logging result images. In addition, using an optical borehole televiewer a good and detailed realistic colour picture of the borehole wall is obtained. From these images the character of the spalls identified may be evaluated further. The heating was performed in a 4 m long section, using a heating cable centred in an 8 m deep vertical borehole, drilled from the floor of the tunnels. For the borehole in the Q-tunnel of AHRL the results from the loggings of the borehole before the heating revealed that breakouts existed even before this pilot test due to previous heating experiments at the site (CAPS). Quite consistent orientation and the typical shape of small breakouts were observed. After the heating the spalling increased slightly at the same locations and a new spalling location also developed at a deeper location in the borehole. At ONKALO three very small changes

Systemic EP4 Inhibition Increases Adhesion Formation in a Murine Model of Flexor Tendon Repair.

Directory of Open Access Journals (Sweden)

Michael B Geary

Full Text Available Flexor tendon injuries are a common clinical problem, and repairs are frequently complicated by post-operative adhesions forming between the tendon and surrounding soft tissue. Prostaglandin E2 and the EP4 receptor have been implicated in this process following tendon injury; thus, we hypothesized that inhibiting EP4 after tendon injury would attenuate adhesion formation. A model of flexor tendon laceration and repair was utilized in C57BL/6J female mice to evaluate the effects of EP4 inhibition on adhesion formation and matrix deposition during flexor tendon repair. Systemic EP4 antagonist or vehicle control was given by intraperitoneal injection during the late proliferative phase of healing, and outcomes were analyzed for range of motion, biomechanics, histology, and genetic changes. Repairs treated with an EP4 antagonist demonstrated significant decreases in range of motion with increased resistance to gliding within the first three weeks after injury, suggesting greater adhesion formation. Histologic analysis of the repair site revealed a more robust granulation zone in the EP4 antagonist treated repairs, with early polarization for type III collagen by picrosirius red staining, findings consistent with functional outcomes. RT-PCR analysis demonstrated accelerated peaks in F4/80 and type III collagen (Col3a1 expression in the antagonist group, along with decreases in type I collagen (Col1a1. Mmp9 expression was significantly increased after discontinuing the antagonist, consistent with its role in mediating adhesion formation. Mmp2, which contributes to repair site remodeling, increases steadily between 10 and 28 days post-repair in the EP4 antagonist group, consistent with the increased matrix and granulation zones requiring remodeling in these repairs. These findings suggest that systemic EP4 antagonism leads to increased adhesion formation and matrix deposition during flexor tendon healing. Counter to our hypothesis that EP4 antagonism

A Closer Look at Racism and Heterosexism in Medical Students' Clinical Decision-Making Related to HIV Pre-Exposure Prophylaxis (PrEP): Implications for PrEP Education.

Science.gov (United States)

Calabrese, Sarah K; Earnshaw, Valerie A; Krakower, Douglas S; Underhill, Kristen; Vincent, Wilson; Magnus, Manya; Hansen, Nathan B; Kershaw, Trace S; Mayer, Kenneth H; Betancourt, Joseph R; Dovidio, John F

2018-04-01

Social biases among healthcare providers could limit PrEP access. In this survey study of 115 US medical students, we examined associations between biases (racism and heterosexism) and PrEP clinical decision-making and explored prior PrEP education as a potential buffer. After viewing a vignette about a PrEP-seeking MSM patient, participants reported anticipated patient behavior (condomless sex, extra-relational sex, and adherence), intention to prescribe PrEP to the patient, biases, and background characteristics. Minimal evidence for racism affecting clinical decision-making emerged. In unadjusted analyses, heterosexism indirectly affected prescribing intention via all anticipated behaviors, tested as parallel mediators. Participants expressing greater heterosexism more strongly anticipated increased risk behavior and adherence problems, which were associated with lower prescribing intention. The indirect effect via condomless sex remained significant adjusting for background characteristics. Prior PrEP education did not buffer any indirect effects. Heterosexism may compromise PrEP provision to MSM and should be addressed in PrEP-related medical education.

Method for orienting a borehole core

International Nuclear Information System (INIS)

Henry, W.

1980-01-01

A method is described for longitudinally orienting a borehold core with respect to the longitudinal axis of the drill string which drilled said borehold core in such a manner that the original longitudinal attitude of said borehold core within the earth may be determined. At least a portion of said borehold core is partialy demagnetized in steps to thereby at least partially remove in steps the artificial remanent magnetism imparted to said borehole core by said drill string. The artifical remanent magnetism is oriented substantially parallel to the longitudinal axis of said drill string. The direction and intensity of the total magnetism of said borehold core is measured at desired intervals during the partial demagnetizing procedure. An artificial remanent magnetism vector is established which extends from the final measurement of the direction and intensity of the total magnetism of said borehole core taken during said partial demagnetizing procedure towards the initial measurement of the direction and intensity of the total magnetism of said borehold core taken during said partial demagnetizing procedure. The borehold core is oriented in such a manner that said artificial remanent magnetism vector points at least substantially downwardly towards the bottom of said borehold core for a borehold in the northern hemisphere and points at least substantailly upwardly towards the top of said borehole core for a borehole in the southern hemisphere

Optimization of Deep Borehole Systems for HLW Disposal

International Nuclear Information System (INIS)

Driscoll, Michael; Baglietto, Emilio; Buongiorno, Jacopo; Lester, Richard; Brady, Patrick; Arnold, B. W.

2015-01-01

This is the final report on a project to update and improve the conceptual design of deep boreholes for high level nuclear waste disposal. The effort was concentrated on application to intact US legacy LWR fuel assemblies, but conducted in a way in which straightforward extension to other waste forms, host rock types and countries was preserved. The reference fuel design version consists of a vertical borehole drilled into granitic bedrock, with the uppermost kilometer serving as a caprock zone containing a diverse and redundant series of plugs. There follows a one to two kilometer waste canister emplacement zone having a hole diameter of approximately 40-50 cm. Individual holes are spaced 200-300 m apart to form a repository field. The choice of verticality and the use of a graphite based mud as filler between the waste canisters and the borehole wall liner was strongly influenced by the expectation that retrievability would continue to be emphasized in US and worldwide repository regulatory criteria. An advanced version was scoped out using zinc alloy cast in place to fill void space inside a disposal canister and its encapsulated fuel assembly. This excludes water and greatly improves both crush resistance and thermal conductivity. However the simpler option of using a sand fill was found adequate and is recommended for near-term use. Thermal-hydraulic modeling of the low permeability and porosity host rock and its small (@@@ 1%) saline water content showed that vertical convection induced by the waste's decay heat should not transport nuclides from the emplacement zone up to the biosphere atop the caprock. First order economic analysis indicated that borehole repositories should be cost-competitive with shallower mined repositories. It is concluded that proceeding with plans to drill a demonstration borehole to confirm expectations, and to carry out priority experiments, such as retention and replenishment of in-hole water is in order.

Optimization of Deep Borehole Systems for HLW Disposal

Energy Technology Data Exchange (ETDEWEB)

Driscoll, Michael [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Baglietto, Emilio [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Buongiorno, Jacopo [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Lester, Richard [Massachusetts Inst. of Technology (MIT), Cambridge, MA (United States); Brady, Patrick [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Arnold, B. W. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-09-09

This is the final report on a project to update and improve the conceptual design of deep boreholes for high level nuclear waste disposal. The effort was concentrated on application to intact US legacy LWR fuel assemblies, but conducted in a way in which straightforward extension to other waste forms, host rock types and countries was preserved. The reference fuel design version consists of a vertical borehole drilled into granitic bedrock, with the uppermost kilometer serving as a caprock zone containing a diverse and redundant series of plugs. There follows a one to two kilometer waste canister emplacement zone having a hole diameter of approximately 40-50 cm. Individual holes are spaced 200-300 m apart to form a repository field. The choice of verticality and the use of a graphite based mud as filler between the waste canisters and the borehole wall liner was strongly influenced by the expectation that retrievability would continue to be emphasized in US and worldwide repository regulatory criteria. An advanced version was scoped out using zinc alloy cast in place to fill void space inside a disposal canister and its encapsulated fuel assembly. This excludes water and greatly improves both crush resistance and thermal conductivity. However the simpler option of using a sand fill was found adequate and is recommended for near-term use. Thermal-hydraulic modeling of the low permeability and porosity host rock and its small (≤ 1%) saline water content showed that vertical convection induced by the waste’s decay heat should not transport nuclides from the emplacement zone up to the biosphere atop the caprock. First order economic analysis indicated that borehole repositories should be cost-competitive with shallower mined repositories. It is concluded that proceeding with plans to drill a demonstration borehole to confirm expectations, and to carry out priority experiments, such as retention and replenishment of in-hole water is in order.

Core drilling of deep borehole OL-KR43 at Olkiluoto in Eurajoki 2006

Energy Technology Data Exchange (ETDEWEB)

Niinimaeki, R. [Suomen Malmi Oy, Espoo (Finland)

2006-12-15

, tonalitic-granodioritic- granitic gneiss and pegmatite granite. The average fracture frequency is 1.6 pes/m in borehole OL-KR43 and 1.5 pes/m in borehole OL-KR43B. The average RQD values were 96.2 % and 97.7 %. In borehole OL-KR43 24 fractured zones and in borehole OL-KR43B one fractured zone were penetrated during drilling work. (orig.)

EP4 as a Therapeutic Target for Aggressive Human Breast Cancer

Directory of Open Access Journals (Sweden)

Mousumi Majumder

2018-03-01

selective EP4 antagonists (EP4A could mitigate all of these events tested with cells in vitro as well as in vivo in syngeneic COX-2 expressing mammary cancer bearing mice or immune-deficient mice bearing COX-2 over-expressing human breast cancer xenografts. We suggest that EP4A can avoid thrombo-embolic side effects of long term use of COX-2 inhibitors by sparing cardio-protective roles of PGI2 via IP receptor activation or PGE2 via EP3 receptor activation. Furthermore, we identified two COX-2/EP4 induced oncogenic and SLC-stimulating microRNAs—miR526b and miR655, one of which (miR655 appears to be a potential blood biomarker in breast cancer patients for monitoring SLC-ablative therapies, such as with EP4A. We suggest that EP4A will likely produce the highest benefit in aggressive breast cancers, such as COX-2 expressing triple-negative breast cancers, when combined with other newer agents, such as inhibitors of programmed cell death (PD-1 or PD-L1.

PrEP implementation research in Africa: what is new?

Science.gov (United States)

Cowan, Frances M; Delany-Moretlwe, Sinead; Sanders, Eduard J; Mugo, Nelly R; Guedou, Fernand A; Alary, Michel; Behanzin, Luc; Mugurungi, Owen; Bekker, Linda-Gail

2016-01-01

Of the two million new HIV infections in adults in 2014, 70% occurred in sub-Saharan Africa. Several African countries have already approved guidelines for pre-exposure prophylaxis (PrEP) for individuals at substantial risk of HIV as part of combination HIV prevention but key questions remain about how to identify and deliver PrEP to those at greatest need. Throughout the continent, individuals in sero-discordant relationships, and members of key populations (sex workers, men who have sex with men (MSM), transgender women and injection drug users) are likely to benefit from the availability of PrEP. In addition, adolescent girls and young women (AGYW) are at substantial risk in some parts of the continent. It has been estimated that at least three million individuals in Africa are likely to be eligible for PrEP according to WHO's criteria. Tens of demonstration projects are planned or underway across the continent among a range of countries, populations and delivery settings. In each of the target populations, there are overarching issues related to (i) creating demand for PrEP, (ii) addressing supply-side issues and (iii) providing appropriate and tailored adherence support. Critical for creating demand for PrEP is the normalization of HIV prevention. Community-level interventions which engage opinion leaders as well as empowerment interventions for those at highest risk will be key. Critical to supply of PrEP is that services are accessible for all, including for stigmatized populations. Establishing accessible integrated services provides the opportunity to address other public health priorities including the unmet need for HIV testing, contraception and sexually transmitted infections treatment. National policies need to include minimum standards for training and quality assurance for PrEP implementation and to address supply chain issues. Adherence support needs to recognize that social and structural factors are likely to have an important influence

Borehole stoneley waves and permeability: Laboratory results

International Nuclear Information System (INIS)

Winkler, K.W.; Plona, T.J.; Froelich, B.; Liu, H.L.

1987-01-01

Recent interest in full waveform sonic logging has created the need for full waveform laboratory experiments on model boreholes. Of particular interest is the investigation of Stoneley waves and their interaction with permeable formations. The authors describe experimental results that show how Stoneley wave slowness and attenuation are affected by formation permeability. Both slowness and attenuation (1/Q) are observed to increase with formation permeability. This increase is frequency dependent, being greatest at low frequencies. The presence of simulated mudcakes on the borehole wall reduces the permeability effect on Stoneley waves, but does not eliminate it. The mudcake effect is frequency dependent, being greatest at low frequencies. In our experiments on rocks, the laboratory data is in qualitative agreement with theoretical predictions. In a very well characterized synthetic porous material, theory and experiment are in good quantitative agreement

Poppers and PrEP: Use of Pre-exposure Prophylaxis Among Men Who Have Sex with Men Who Use Inhaled Nitrites.

Science.gov (United States)

Hambrick, H Rhodes; Park, Su Hyun; Schneider, John A; Mayer, Kenneth H; Carrico, Adam W; Sherman, Scott E; Duncan, Dustin T

2018-05-09

Men who have sex with men (MSM) commonly use inhaled nitrites, or poppers, though their use is a risk factor HIV seroconversion. Pre-exposure prophylaxis, or PrEP, is effective for HIV prevention, but is not widely used, and little is known regarding PrEP use and acceptability among MSM who use inhaled nitrites. We surveyed 580 MSM in Paris, France in 2016 about popper use, sexual behaviors including condomless anal intercourse (CAI), serosorting, and sexual positioning, PrEP use, PrEP candidacy, and interest in alternate PrEP delivery modalities. We included 444 HIV negative participants for the current study. 46.2% reported popper use in the prior 3 months. Using multivariate adjusted logistic regression, we found that popper users were more likely than non-users to consider themselves candidates for PrEP [adjusted relative risk ratio (aRRR) = 2.73; 95% CI 1.54-4.83], but they were not more likely to be current (aRRR = 1.54; 95% CI 0.71-3.33) or past (aRRR = 1.37; 95% CI 0.44-4.28) PrEP users. Mediation analyses indicated that increased CAI and serosorting partly explained the relationship between popper use and PrEP candidacy. There was considerable interest in alternate proposed PrEP delivery modalities, particularly long-acting injectable PrEP [adjusted risk ratio (aRR) = 1.43; 95% CI 1.15-1.79].

Comparative study of coliform contamination of public boreholes ...

African Journals Online (AJOL)

This study was carried out to determine the coliform contamination of public boreholes and pipe borne water supplies within Bosso town. Twenty (20) water samples comprising of 10 each of borehole and pipe borne samples were aseptically collected from Bosso Town and analyzed using membrane filtration technique.

VTT test borehole for bedrock investigations

International Nuclear Information System (INIS)

Okko, O.; Hassinen, P.; Front, K.

1994-02-01

A borehole of depth 150 m and diameter 56 mm has been drilled in the area adjacent to the premises of the Technical Research Centre of Finland (VTT) at Otaniemi, Espoo, for the purposes of calibrating geophysical measurements devices. This report presents the test results obtained so far and illustrates the processing of these, in which the various measurements are plotted as curves and combinations of curves. The interpretations provided so far consists of analyses of lithological variations, bedrock fracturing, the nature and occurrence of fracture zones and groundwater flow patterns. Samples were taken from those parts of the core shown by the borehole measurements to be homogenous and thin sections made from these for mineralogical determinations. The rock mechanical and petrophysical properties of the same points were examined. The core is in the possession of VTT, and the hole itself is available to outsiders for the calibration and testing of borehole measurement equipment. (orig.). (21 refs., 13 figs., 5 tabs.)

Site study plan for borehole search and characterization, Deaf Smith County Site, Texas: Revision 1

International Nuclear Information System (INIS)

1987-01-01

This site study plan describes the Borehole Search and Characterization field activities to be conducted during the early stages of Site Characterization at the Deaf Smith County site, Texas. The field program has been designed to provide data useful in addressing information/data needs resulting from Federal/State/Local regulatory requirements and repository program requirements. Air and ground surveys, an extensive literature search, and landowner interviews will be conducted to locate wells within and adjacent to the proposed nuclear waste repository site in Deaf Smith County. Initially, the study will center around the planned Exploratory Shaft Facilities location and will expand outward from that location. Findings from this study may lead to preparation of a new site study plan to search suspected borehole locations, and excavate or reenter known boreholes for additional characterization or remedial action. The Salt Repository Project (SRP) Networks specify the schedule under which the program will operate. The Technical Field Services Contractor (TFSC) is responsible for conducting the field program. Data will be handled and reported in accordance with established SRP procedures. A quality assurance program will be utilized to assure that activities affecting quality are performed correctly and that appropriate documentation is maintained. 13 refs., 6 figs., 3 tabs

Novel Emplacement Device for a Very Deep Borehole Disposal

Energy Technology Data Exchange (ETDEWEB)

Lee, Min Soo; Choi, Heui-joo; Lee, Jong Yul [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

There is a worldwide attempt of HLW disposal into a very deep borehole of around 3-5 km depth with the advancement of an underground excavation technology recently. As it goes into deeper underground, the rock becomes more uniform and flawless. And then the underground water circulation system at 3-5 km depth is almost disconnected with near groundwater circulation system. The canister integrity is less important in this very deep borehole disposal system unlike a general geologic disposal system at 500 m. In the deep borehole disposal procedures, one SNF (Spent Nuclear Fuel) assembly is stored in one disposal canister (D30-40cm, H4.7-5.0m), and approximately 10-40 disposal canisters are connected axially, which parade length can leach to around 200m in maximum. The connected canister parade is lowered through a very deep borehole (D40-50cm) by emplacement devices. Therefore the connections between canisters and canister to lowering joint are very important for the safe operation of it. The well-known connection method between canisters is Threaded Coupled Connection method, in which releasing of the connection is almost impossible after thread fastening in the borehole. The novel joint device suggested in this paper can accommodate a canister emplacement and retrieval in the borehole disposal process. The joint can be lowered by bound to a drilling pipe, or high tension cable along 3-5 km distance. This novel device can cope with an accidental event easily without any joint head change. When canisters are damaged or stuck on the borehole wall during their descending, the canisters in trouble can be retrieved simply by the control of a lifting speed.

Deep Borehole Disposal Concept: Development of Universal Canister Concept of Operations

Energy Technology Data Exchange (ETDEWEB)

Rigali, Mark J. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Applied Systems Analysis and Research; Price, Laura L. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Applied Systems Analysis and Research

2016-08-01

This report documents key elements of the conceptual design for deep borehole disposal of radioactive waste to support the development of a universal canister concept of operations. A universal canister is a canister that is designed to be able to store, transport, and dispose of radioactive waste without the canister having to be reopened to treat or repackage the waste. This report focuses on the conceptual design for disposal of radioactive waste contained in a universal canister in a deep borehole. The general deep borehole disposal concept consists of drilling a borehole into crystalline basement rock to a depth of about 5 km, emplacing WPs in the lower 2 km of the borehole, and sealing and plugging the upper 3 km. Research and development programs for deep borehole disposal have been ongoing for several years in the United States and the United Kingdom; these studies have shown that deep borehole disposal of radioactive waste could be safe, cost effective, and technically feasible. The design concepts described in this report are workable solutions based on expert judgment, and are intended to guide follow-on design activities. Both preclosure and postclosure safety were considered in the development of the reference design concept. The requirements and assumptions that form the basis for the deep borehole disposal concept include WP performance requirements, radiological protection requirements, surface handling and transport requirements, and emplacement requirements. The key features of the reference disposal concept include borehole drilling and construction concepts, WP designs, and waste handling and emplacement concepts. These features are supported by engineering analyses.

Clinical Applications for EPs in the ICU.

Science.gov (United States)

Koenig, Matthew A; Kaplan, Peter W

2015-12-01

In critically ill patients, evoked potential (EP) testing is an important tool for measuring neurologic function, signal transmission, and secondary processing of sensory information in real time. Evoked potential measures conduction along the peripheral and central sensory pathways with longer-latency potentials representing more complex thalamocortical and intracortical processing. In critically ill patients with limited neurologic exams, EP provides a window into brain function and the potential for recovery of consciousness. The most common EP modalities in clinical use in the intensive care unit include somatosensory evoked potentials, brainstem auditory EPs, and cortical event-related potentials. The primary indications for EP in critically ill patients are prognostication in anoxic-ischemic or traumatic coma, monitoring for neurologic improvement or decline, and confirmation of brain death. Somatosensory evoked potentials had become an important prognostic tool for coma recovery, especially in comatose survivors of cardiac arrest. In this population, the bilateral absence of cortical somatosensory evoked potentials has nearly 100% specificity for death or persistent vegetative state. Historically, EP has been regarded as a negative prognostic test, that is, the absence of cortical potentials is associated with poor outcomes while the presence cortical potentials are prognostically indeterminate. In recent studies, the presence of middle-latency and long-latency potentials as well as the amplitude of cortical potentials is more specific for good outcomes. Event-related potentials, particularly mismatch negativity of complex auditory patterns, is emerging as an important positive prognostic test in patients under comatose. Multimodality predictive algorithms that combine somatosensory evoked potentials, event-related potentials, and clinical and radiographic factors are gaining favor for coma prognostication.

Search for leptoquark bosons in ep collisions at HERA

Science.gov (United States)

H1 Collaboration; Aktas, A.; Andreev, V.; Anthonis, T.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Babaev, A.; Backovic, S.; Bähr, J.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Baudrand, S.; Baumgartner, S.; Becker, J.; Beckingham, M.; Behnke, O.; Behrendt, O.; Belousov, A.; Berger, Ch.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bracinik, J.; Brandt, G.; Brisson, V.; Brown, D. P.; Bruncko, D.; Büsser, F. W.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Caron, S.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Contreras, J. G.; Coughlan, J. A.; Cox, B. E.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Dau, W. D.; Daum, K.; de Boer, Y.; Delcourt, B.; de Roeck, A.; Desch, K.; de Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eichler, R.; Eisele, F.; Ellerbrock, M.; Elsen, E.; Erdmann, W.; Essenov, S.; Falkewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Ferencei, J.; Finke, L.; Fleischer, M.; Fleischmann, P.; Fleming, Y. H.; Flucke, G.; Fomenko, A.; Foresti, I.; Franke, G.; Frisson, T.; Gabathuler, E.; Garutti, E.; Gayler, J.; Gerlich, C.; Ghazaryan, S.; Ginzburgskaya, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gorbounov, S.; Goyon, C.; Grab, C.; Greenshaw, T.; Gregori, M.; Grell, B. R.; Grindhammer, G.; Gwilliam, C.; Haidt, D.; Hajduk, L.; Hansson, M.; Heinzelmann, G.; Henderson, R. C. W.; Henschel, H.; Henshaw, O.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Ibbotson, M.; Ismail, M.; Jacquet, M.; Janauschek, L.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, A. W.; Jung, H.; Kapichine, M.; Katzy, J.; Keller, N.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knies, G.; Knutsson, A.; Korbel, V.; Kostka, P.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Kückens, J.; Landon, M. P. J.; Lange, W.; Laštovička, T.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Leißner, B.; Lendermann, V.; Levonian, S.; Lindfeld, L.; Lipka, K.; Liptaj, A.; List, B.; Lobodzinska, E.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lueders, H.; Lüke, D.; Lux, T.; Lytkin, L.; Makankine, A.; Malden, N.; Malinovski, E.; Mangano, S.; Marage, P.; Marshall, R.; Martisikova, M.; Martyn, H.-U.; Maxfield, S. J.; Meer, D.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, J.; Mikocki, S.; Milcewicz-Mika, I.; Milstead, D.; Mladenov, D.; Mohamed, A.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nikitin, D.; Nowak, G.; Nozicka, M.; Oganezov, R.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Papadopoulou, T.; Pascaud, C.; Patel, G. D.; Peez, M.; Perez, E.; Perez-Astudillo, D.; Perieanu, A.; Petrukhin, A.; Pitzl, D.; Plačakytė, R.; Portheault, B.; Povh, B.; Prideaux, P.; Raicevic, N.; Reimer, P.; Rimmer, A.; Risler, C.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rurikova, Z.; Rusakov, S.; Salvaire, F.; Sankey, D. P. C.; Sauvan, E.; Schätzel, S.; Schilling, F.-P.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schröder, V.; Schultz-Coulon, H.-C.; Sedlák, K.; Sefkow, F.; Shaw-West, R. N.; Sheviakov, I.; Shtarkov, L. N.; Sirois, Y.; Sloan, T.; Smirnov, P.; Soloviev, Y.; South, D.; Spaskov, V.; Specka, A.; Stella, B.; Stiewe, J.; Strauch, I.; Straumann, U.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Tomasz, F.; Traynor, D.; Truöl, P.; Tsakov, I.; Tsipolitis, G.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, M.; Usik, A.; Utkin, D.; Valkár, S.; Valkárová, A.; Vallée, C.; van Mechelen, P.; van Remortel, N.; Vargas Trevino, A.; Vazdik, Y.; Veelken, C.; Vest, A.; Vinokurova, S.; Volchinski, V.; Vujicic, B.; Wacker, K.; Wagner, J.; Weber, G.; Weber, R.; Wegener, D.; Werner, C.; Werner, N.; Wessels, M.; Wessling, B.; Wigmore, C.; Wissing, Ch.; Wolf, R.; Wünsch, E.; Xella, S.; Yan, W.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y. C.; Zimmermann, J.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2005-11-01

A search for scalar and vector leptoquarks coupling to first generation fermions is performed using the ep and ep scattering data collected by the H1 experiment between 1994 and 2000. The data correspond to a total integrated luminosity of 117 pb. No evidence for the direct or indirect production of such particles is found in data samples with a large transverse momentum final state electron or with large missing transverse momentum. Constraints on leptoquark models are established. For leptoquark couplings of electromagnetic strength, leptoquarks with masses up to 275 325 GeV are ruled out at 95% confidence level. These limits improve and supercede earlier H1 limits based on subsamples of the data used here.

Drilling, construction, geophysical log data, and lithologic log for boreholes USGS 142 and USGS 142A, Idaho National Laboratory, Idaho

Science.gov (United States)

Twining, Brian V.; Hodges, Mary K.V.; Schusler, Kyle; Mudge, Christopher

2017-07-27

Starting in 2014, the U.S. Geological Survey in cooperation with the U.S. Department of Energy, drilled and constructed boreholes USGS 142 and USGS 142A for stratigraphic framework analyses and long-term groundwater monitoring of the eastern Snake River Plain aquifer at the Idaho National Laboratory in southeast Idaho. Borehole USGS 142 initially was cored to collect rock and sediment core, then re-drilled to complete construction as a screened water-level monitoring well. Borehole USGS 142A was drilled and constructed as a monitoring well after construction problems with borehole USGS 142 prevented access to upper 100 feet (ft) of the aquifer. Boreholes USGS 142 and USGS 142A are separated by about 30 ft and have similar geology and hydrologic characteristics. Groundwater was first measured near 530 feet below land surface (ft BLS) at both borehole locations. Water levels measured through piezometers, separated by almost 1,200 ft, in borehole USGS 142 indicate upward hydraulic gradients at this location. Following construction and data collection, screened water-level access lines were placed in boreholes USGS 142 and USGS 142A to allow for recurring water level measurements.Borehole USGS 142 was cored continuously, starting at the first basalt contact (about 4.9 ft BLS) to a depth of 1,880 ft BLS. Excluding surface sediment, recovery of basalt, rhyolite, and sediment core at borehole USGS 142 was approximately 89 percent or 1,666 ft of total core recovered. Based on visual inspection of core and geophysical data, material examined from 4.9 to 1,880 ft BLS in borehole USGS 142 consists of approximately 45 basalt flows, 16 significant sediment and (or) sedimentary rock layers, and rhyolite welded tuff. Rhyolite was encountered at approximately 1,396 ft BLS. Sediment layers comprise a large percentage of the borehole between 739 and 1,396 ft BLS with grain sizes ranging from clay and silt to cobble size. Sedimentary rock layers had calcite cement. Basalt flows

Comparison between results of detailed tectonic studies on borehole core vs microresistivity images of borehole wall from gas-bearing shale complexes, Baltic Basin, Poland.

Science.gov (United States)

Bobek, Kinga; Jarosiński, Marek; Pachytel, Radomir

2017-04-01

Structural analysis of borehole core and microresistivity images yield an information about geometry of natural fracture network and their potential importance for reservoir stimulation. Density of natural fractures and their orientation in respect to the maximum horizontal stress has crucial meaning for hydraulic fractures propagation in unconventional reservoirs. We have investigated several hundred meters of continuous borehole core and corresponding microresistivity images (mostly XRMI) from six boreholes in the Pomeranian part of the Early Paleozoic Baltic Basin. In general, our results challenge the question about representatives of statistics based on structural analyses on a small shale volume represented by borehole core or borehole wall images and credibility of different sets of data. Most frequently, fractures observed in both XRMI and cores are steep, small strata-bound fractures and veins with minor mechanical aperture (0,1 mm in average). These veins create an orthogonal joint system, locally disturbed by fractures associated with normal or by gently dipping thrust faults. Mean fractures' height keeps in a range between 30-50 cm. Fracture density differs significantly among boreholes and Consistent Lithological Units (CLUs) but the most frequent means falls in a range 2-4 m-1. We have also payed an attention to bedding planes due to their expected coupling with natural fractures and their role as structural barriers for vertical fracture propagation. We aimed in construction for each CLU the so-called "mean brick", which size is limited by an average distance between two principal joint sets and between bedding fractures. In our study we have found out a discrepancy between structural profiles based on XRMI and core interpretation. For some CLUs joint fractures densities, are higher in cores than in XRMI. In this case, numerous small fractures were not recorded due to the limits of XRMI resolution. However, the most veins with aperture 0,1 mm

Virtual Compton scattering off the proton at Jefferson Lab (experiment E93050): preliminary results of the cross-sections of the reaction (ep{yields}ep{gamma}) in order to find out the generalized polarizabilities (GPs) of the proton at Q{sup 2} = 1.9 GeV{sup 2}; Diffusion compton virtuelle a jefferson lab (experience E93050): resultat preliminaire des sections efficaces (ep{yields}ep{gamma}) en vue d'extraire les polarisabilites generalisees du proton a Q{sup 2} = 1.9 GEV{sup 2}

Energy Technology Data Exchange (ETDEWEB)

Jaminion, St

2000-12-01

Virtual Compton Scattering off the proton ({gamma}{sup *}p {yields} {gamma}p) at low energy is accessible via the reaction (ep {yields} ep{gamma}), and contains 6 new observables: Generalized Polarizabilities (GPs). Their extraction needs the measurement of absolute five fold differential cross sections for photon electroproduction off the proton. The determination of GPs will put new constraints on models of nucleon structure in the non-perturbative Quantum Chromodynamics region. Following the Mainz experiment realized at four momentum transfer Q{sup 2} = 0.33 GeV{sup 2}, the E93050 experiment which was performed in the Hall A of Jefferson Lab during march-april 1998, will allow the measurement of combinations of generalized polarizabilities at Q{sup 2}=1 and 1.9 GeV{sup 2}. The final electron and proton were detected in coincidence in the Hall A high resolution spectrometers. The final photon is reconstructed like a missing particle, and all its variables can be determined. We had to optimize optics tensor of each spectrometer in order to have the best reconstruction at vertex point. We created an acceptance function, which is included in the software simulating solid angle. We determined different cuts to substract our background dominating (ep {yields} ep{gamma}) reaction. This work allows to carry out our first photon electro-production cross section measurement at Q{sup 2}=1.9 GeV{sup 2}. The results seem to indicate a measurable effect of generalized polarizabilities, which remains however to be confirmed. (author)

PrEP implementation in the Asia-Pacific region: opportunities, implementation and barriers

Science.gov (United States)

Zablotska, Iryna; Grulich, Andrew E; Phanuphak, Nittaya; Anand, Tarandeep; Janyam, Surang; Poonkasetwattana, Midnight; Baggaley, Rachel; van Griensven, Frits; Lo, Ying-Ru

2016-01-01

Introduction HIV epidemics in the Asia-Pacific region are concentrated among men who have sex with men (MSM) and other key populations. Pre-exposure prophylaxis (PrEP) is an effective HIV prevention intervention and could be a potential game changer in the region. We discuss the progress towards PrEP implementation in the Asia-Pacific region, including opportunities and barriers. Discussion Awareness about PrEP in the Asia-Pacific is still low and so are its levels of use. A high proportion of MSM who are aware of PrEP are willing to use it. Key PrEP implementation barriers include poor knowledge about PrEP, limited access to PrEP, weak or non-existent HIV prevention programmes for MSM and other key populations, high cost of PrEP, stigma and discrimination against key populations and restrictive laws in some countries. Only several clinical trials, demonstration projects and a few larger-scale implementation studies have been implemented so far in Thailand and Australia. However, novel approaches to PrEP implementation have emerged: researcher-, facility- and community-led models of care, with PrEP services for fee and for free. The WHO consolidated guidelines on HIV testing, treatment and prevention call for an expanded access to PrEP worldwide and have provided guidance on PrEP implementation in the region. Some countries like Australia have released national PrEP guidelines. There are growing community leadership and consultation processes to initiate PrEP implementation in Asia and the Pacific. Conclusions Countries of the Asia-Pacific region will benefit from adding PrEP to their HIV prevention packages, but for many this is a critical step that requires resourcing. Having an impact on the HIV epidemic requires investment. The next years should see the region transitioning from limited PrEP implementation projects to growing access to PrEP and expansion of HIV prevention programmes. PMID:27760688

The experimental results and analysis of a borehole radar prototype

International Nuclear Information System (INIS)

Liu, Sixin; Wu, Junjun; Dong, Hang; Fu, Lei; Wang, Fei

2012-01-01

A prototype of borehole radar has been successfully tested in three sites for different purposes under a field condition. The objective of the prototype is providing an effective down-hole tool for detecting targets in deep boreholes situated in a relatively high conductivity area such as the metal ores. The first testing site is at a geothermal field. The fractures extending more than 20 m from the borehole are delineated by the borehole radar in the single-hole reflection mode. The second testing site is located in a jade mine for basement evaluation. The cross-hole measurement mode was used to detect the cavities made by previous unorganized mining activities. Several high-velocity anomalies were found in the velocity profile and presumably the targets of the mine shafts and tunnels. The third test site is located in a mineralized belt characterized by low resistivity less than 1000 Ohm m, the surface-borehole measurement was carried out and the data were processed with velocity tomography. The low-velocity zone corresponds to a mineralized zone from geological records. The three testing results proved the readiness of this borehole radar prototype for further deployment in more complicated and realistic field situations. (paper)

Cement technology for plugging boreholes in radioactive-waste-repository sites. Progress report, October 1, 1978-September 30, 1979

International Nuclear Information System (INIS)

Moore, J.G.; Morgan, M.T.; McDaniel, E.W.; Greene, H.B.; West, G.A.

1980-08-01

Laboratory evaluations were made of several borehole plug formulations proposed for the Bell Canyon field test. Measurements included compressive strength, permeability, density, and thermal conductivity. A few preliminary tests with saltcrete formulations showed no significant difference in physical properties of the solid as a function of fly ash or cement composition. The saltcrete proposed for the field test gave acceptable pushout strength and permeability values using miniature borehole plugs in anhydrite. Similar laboratory tests made with a freshwater formulation indicated high permeability. Electron micrographs showed dissolution cavities or cracks at the plug-wall interface. These studies showed that the reactions occurring between the borehole plug and the adjacent rock wall are an important factor in obtaining a good seal and that laboratory tests are useful to indicate the possibility of success or failure of field tests

Palynological characterization of Givetian-Frasnian deposits in the reference Borehole section 1-Balneologicheskaya (Southern Timan)

Science.gov (United States)

Tel'Nova, O. P.

2008-04-01

A succession of seven palynological assemblages characterizing the Yuzhnyi Timan, Taman, Ust-Yarega, Domanik, and Vetlosyan formations of the southern Timan is established in the Givetian-Frasnian deposits recovered by Borehole 1-Balneologicheskaya and studied in detail. Five individual zones, which are distinguished within stratigraphic range of the optivus-krestovnicovii miospore zone, can be of basic importance for a high-resolution stratigraphic subdivision of the sedimentation stage under consideration. Phytostratigraphic boundary corresponding to the Frasnian Stage base in the East European platform is substantiated in palynological aspect.

Expression, purification, crystallization and preliminary X-ray studies of Vibrio cholerae pseudopilin EpsH

International Nuclear Information System (INIS)

Raghunathan, Kannan; Vago, Frank S.; Ball, Terry; Yakubova, Nafissa; Grindem, David; Wedemeyer, William J.; Arvidson, Dennis N.

2009-01-01

Recombinant V. cholerae EpsH has been expressed, purified and crystallized. The crystals diffracted to 1.71 Å resolution. EpsH is a minor pseudopilin protein of the Vibrio cholerae type II secretion system. A truncated form of EpsH with a C-terminal noncleavable His tag was constructed and expressed in Escherichia coli, purified and crystallized by sitting-drop vapor diffusion. A complete data set was collected to 1.71 Å resolution. The crystals belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 53.39, b = 71.11, c = 84.64 Å. There were two protein molecules in the asymmetric unit, which gave a Matthews coefficient V M of 2.1 Å 3 Da −1 , corresponding to 41.5% solvent content

DISTRIBUTION OF BOREHOLES IN RESIDENTIAL LAYOUTS AND ...

African Journals Online (AJOL)

IPPIS NAU

2017-07-01

Jul 1, 2017 ... Lack of adequate public water supply to the inhabitants of Awka urban area since the urban water supply scheme at Imo ... investigate the distribution pattern of boreholes in some new settlements within the urban area to see whether their ..... The urban sprawl has resulted in the conversion of hitherto rural ...

EP-DNN: A Deep Neural Network-Based Global Enhancer Prediction Algorithm.

Science.gov (United States)

Kim, Seong Gon; Harwani, Mrudul; Grama, Ananth; Chaterji, Somali

2016-12-08

We present EP-DNN, a protocol for predicting enhancers based on chromatin features, in different cell types. Specifically, we use a deep neural network (DNN)-based architecture to extract enhancer signatures in a representative human embryonic stem cell type (H1) and a differentiated lung cell type (IMR90). We train EP-DNN using p300 binding sites, as enhancers, and TSS and random non-DHS sites, as non-enhancers. We perform same-cell and cross-cell predictions to quantify the validation rate and compare against two state-of-the-art methods, DEEP-ENCODE and RFECS. We find that EP-DNN has superior accuracy with a validation rate of 91.6%, relative to 85.3% for DEEP-ENCODE and 85.5% for RFECS, for a given number of enhancer predictions and also scales better for a larger number of enhancer predictions. Moreover, our H1 → IMR90 predictions turn out to be more accurate than IMR90 → IMR90, potentially because H1 exhibits a richer signature set and our EP-DNN model is expressive enough to extract these subtleties. Our work shows how to leverage the full expressivity of deep learning models, using multiple hidden layers, while avoiding overfitting on the training data. We also lay the foundation for exploration of cross-cell enhancer predictions, potentially reducing the need for expensive experimentation.

EP-DNN: A Deep Neural Network-Based Global Enhancer Prediction Algorithm

Science.gov (United States)

Kim, Seong Gon; Harwani, Mrudul; Grama, Ananth; Chaterji, Somali

2016-12-01

We present EP-DNN, a protocol for predicting enhancers based on chromatin features, in different cell types. Specifically, we use a deep neural network (DNN)-based architecture to extract enhancer signatures in a representative human embryonic stem cell type (H1) and a differentiated lung cell type (IMR90). We train EP-DNN using p300 binding sites, as enhancers, and TSS and random non-DHS sites, as non-enhancers. We perform same-cell and cross-cell predictions to quantify the validation rate and compare against two state-of-the-art methods, DEEP-ENCODE and RFECS. We find that EP-DNN has superior accuracy with a validation rate of 91.6%, relative to 85.3% for DEEP-ENCODE and 85.5% for RFECS, for a given number of enhancer predictions and also scales better for a larger number of enhancer predictions. Moreover, our H1 → IMR90 predictions turn out to be more accurate than IMR90 → IMR90, potentially because H1 exhibits a richer signature set and our EP-DNN model is expressive enough to extract these subtleties. Our work shows how to leverage the full expressivity of deep learning models, using multiple hidden layers, while avoiding overfitting on the training data. We also lay the foundation for exploration of cross-cell enhancer predictions, potentially reducing the need for expensive experimentation.

Implications of HIV PrEP Trials Results

Science.gov (United States)

Anton, Peter; Fletcher, Courtney V.; DeGruttola, Victor; McGowan, Ian; Becker, Stephen; Zwerski, Sheryl; Burns, David

2011-01-01

Abstract Six randomized clinical trials have been implemented to examine the efficacy of tenofovir disoproxil fumarate (TDF) and/or TDF/emtricitabine (TDF/FTC) as preexposure prophylaxis for HIV-1 infection (PrEP). Although largely complementary, the six trials have many similar features. As the earliest results become available, an urgent question may arise regarding whether changes should be made in the conduct of the other trials. To consider this in advance, a Consultation on the Implications of HIV Pre-Exposure Prophylaxis (PrEP) Trials Results sponsored by the Division of AIDS (DAIDS) of the National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), and the Bill and Melinda Gates Foundation (BMGF) was held on January 29, 2010, at the Natcher Conference Center, NIH, Bethesda, MD. Participants included basic scientists, clinical researchers (including investigators performing the current PrEP trials), and representatives from the U.S. Food and Drug Administration (FDA) and the agencies sponsoring the trials: the U.S. Centers for Disease Control and Prevention (CDC), the U.S. Agency for International Development (USAID), the BMGF, and the U.S. NIH. We report here a summary of the presentations and highlights of salient discussion topics from this workshop. PMID:20969483

COX-2 and Prostaglandin EP3/EP4 Signaling Regulate the Tumor Stromal Proangiogenic Microenvironment via CXCL12-CXCR4 Chemokine Systems

Science.gov (United States)

Katoh, Hiroshi; Hosono, Kanako; Ito, Yoshiya; Suzuki, Tatsunori; Ogawa, Yasufumi; Kubo, Hidefumi; Kamata, Hiroki; Mishima, Toshiaki; Tamaki, Hideaki; Sakagami, Hiroyuki; Sugimoto, Yukihiko; Narumiya, Shuh; Watanabe, Masahiko; Majima, Masataka

2010-01-01

Bone marrow (BM)–derived hematopoietic cells, which are major components of tumor stroma, determine the tumor microenvironment and regulate tumor phenotypes. Cyclooxygenase (COX)−2 and endogenous prostaglandins are important determinants for tumor growth and tumor-associated angiogenesis; however, their contributions to stromal formation and angiogenesis remain unclear. In this study, we observed that Lewis lung carcinoma cells implanted in wild-type mice formed a tumor mass with extensive stromal formation that was markedly suppressed by COX-2 inhibition, which reduced the recruitment of BM cells. Notably, COX-2 inhibition attenuated CXCL12/CXCR4 expression as well as expression of several other chemokines. Indeed, in a Matrigel model, prostaglandin (PG) E2 enhanced stromal formation and CXCL12/CXCR4 expression. In addition, a COX-2 inhibitor suppressed stromal formation and reduced expression of CXCL12/CXCR4 and a fibroblast marker (S100A4) in a micropore chamber model. Moreover, stromal formation after tumor implantation was suppressed in EP3−/− mice and EP4−/− mice, in which stromal expression of CXCL12/CXCR4 and S100A4 was reduced. The EP3 or EP4 knockout suppressed S100A4+ fibroblasts, CXCL12+, and/or CXCR4+ stromal cells as well. Immunofluorescent analyses revealed that CXCL12+CXCR4+S100A4+ fibroblasts mainly comprised stromal cells and most of these were recruited from the BM. Additionally, either EP3- or EP4-specific agonists stimulated CXCL12 expression by fibroblasts in vitro. The present results address the novel activities of COX-2/PGE2-EP3/EP4 signaling that modulate tumor biology and show that CXCL12/CXCR4 axis may play a crucial role in tumor stromal formation and angiogenesis under the control of prostaglandins. PMID:20110411

Comparison of Performance of Public and Private Boreholes ...

African Journals Online (AJOL)

In the last fifteen years, a remarkable increase in the number of privately owned. There has been an increase in the individually owned and operated boreholes within the state because it is claimed that government owned boreholes breakdown too often. Hence, this study is aimed at comparison of the performance of three ...

Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure

Science.gov (United States)

Roth, Caleb C.; Barnes Jr., Ronald A.; Ibey, Bennett L.; Beier, Hope T.; Christopher Mimun, L.; Maswadi, Saher M.; Shadaram, Mehdi; Glickman, Randolph D.

2015-01-01

The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. However, the delivery of a high-voltage nsEP to cells by tungsten electrodes creates a multitude of biophysical phenomena, including electrohydraulic cavitation, electrochemical interactions, thermoelastic expansion, and others. To date, very limited research has investigated non-electric phenomena occurring during nsEP exposures and their potential effect on cell nanoporation. Of primary interest is the production of acoustic shock waves during nsEP exposure, as it is known that acoustic shock waves can cause membrane poration (sonoporation). Based on these observations, our group characterized the acoustic pressure transients generated by nsEP and determined if such transients played any role in nanoporation. In this paper, we show that nsEP exposures, equivalent to those used in cellular studies, are capable of generating high-frequency (2.5 MHz), high-intensity (>13 kPa) pressure transients. Using confocal microscopy to measure cell uptake of YO-PRO®-1 (indicator of nanoporation of the plasma membrane) and changing the electrode geometry, we determined that acoustic waves alone are not responsible for poration of the membrane. PMID:26450165

Characterization of Pressure Transients Generated by Nanosecond Electrical Pulse (nsEP) Exposure.

Science.gov (United States)

Roth, Caleb C; Barnes, Ronald A; Ibey, Bennett L; Beier, Hope T; Christopher Mimun, L; Maswadi, Saher M; Shadaram, Mehdi; Glickman, Randolph D

2015-10-09

The mechanism(s) responsible for the breakdown (nanoporation) of cell plasma membranes after nanosecond pulse (nsEP) exposure remains poorly understood. Current theories focus exclusively on the electrical field, citing electrostriction, water dipole alignment and/or electrodeformation as the primary mechanisms for pore formation. However, the delivery of a high-voltage nsEP to cells by tungsten electrodes creates a multitude of biophysical phenomena, including electrohydraulic cavitation, electrochemical interactions, thermoelastic expansion, and others. To date, very limited research has investigated non-electric phenomena occurring during nsEP exposures and their potential effect on cell nanoporation. Of primary interest is the production of acoustic shock waves during nsEP exposure, as it is known that acoustic shock waves can cause membrane poration (sonoporation). Based on these observations, our group characterized the acoustic pressure transients generated by nsEP and determined if such transients played any role in nanoporation. In this paper, we show that nsEP exposures, equivalent to those used in cellular studies, are capable of generating high-frequency (2.5 MHz), high-intensity (>13 kPa) pressure transients. Using confocal microscopy to measure cell uptake of YO-PRO®-1 (indicator of nanoporation of the plasma membrane) and changing the electrode geometry, we determined that acoustic waves alone are not responsible for poration of the membrane.

Site characterization and validation - monitoring of saline tracer transport by borehole radar measurements

International Nuclear Information System (INIS)

Olsson, O.; Andersson, P.; Gustafsson, E.

1991-08-01

The objective of this experiment was to map tracer transport in fractured crystalline rock through a combination of radar difference tomography and measurements of tracer concentration in boreholes and the validation drift. The experiment was performed twice, first the D-boreholes were used as a sink and then they were replaced by the validation drift and the experiment repeated. In both experiments saline tracer (200 ml/min, 2% salinity) was injected into fracture zone H about 25 m from the validation drift. The experiment revealed an inhomogeneous transmissivity distribution in Zone H. A significant portion of the tracer is transported upwards along Zone H and towards boreholes T1, T2, and W1. The breakthrough data from both experiments indicate that there are two major transport paths from borehole C2 to the D-boreholes/validation drift. One slow and diluted path to the bottom of the drift which carries the bulk of the mass and one fast path to the crown of the drift with high tracer concentration. The radar difference tomograms show that some tracer is lost through Zone S which intersects Zone H and is nearly perpendicular to it. The intersection between the two zones seems to constitute a preferred flow path. The breakthrough data and the radar difference tomograms have also been used to estimate flow porosity. The estimate obtained area of the same order approximately 10 -4 . (au) (28 refs.)

Borehole logging system

International Nuclear Information System (INIS)

Allen, L.S.

1988-01-01

A radioactive borehole logging tool employs an epithermal neutron detector having a neutron counter surrounded by an inner thermal neutron filter and an outer thermal neutron filter. Located between the inner and outer filters is a neutron moderating material for extending the lifetime of epithermal neutrons to enhance the counting rate of such epithermal neutrons by the neutron counter

200-UP-1 Operable Unit borehole summary report for FY 1995

International Nuclear Information System (INIS)

Darrach, M.E.

1996-07-01

This report details the well construction, sampling, analyses, and geologic character of the Ringold Formation as it was encountered in five wells drilled in the 200-UP-1 Operable Unit during fiscal year (FY) 1995. The 200-UP-1 Interim Remedial Measure Drilling Description of Work was prepared to support the FY 95 field work and presented the specific field activities and procedural requirements to be implemented. The geology of the vadose zone is not described in the text of this report. Vadose zone geology in the immediate area is characterized in sufficient detail in existing documents. However, the borehole logs and well summary sheets provided in the appendices depict the vadose zone stratigraphy and well construction details. Sieve analyses conducted on sediments from the saturated zone were used to design the well completions; these analyses are included. Where applicable, inferences are made concerning the geologic character of the saturated interval. In addition, a synopsis of the preliminary well development process is outlined. Other related information is included with this report as supplemental data

R&D for the Post-EP Processes of Superconducting RF Cavity

Energy Technology Data Exchange (ETDEWEB)

Saeki, Takayuki [KEK; Funahashi, Y. [KEK; Hayano, H. [KEK; Kato, Seigo [KEK; Nishiwaki, Michiru [KEK; Sawabe, Motoaki [KEK; Ueno, Kenji [KEK; Watanabe, K. [KEK; Antoine, Claire [CEA, Gif-sur-Yvette; Berry, Stefurn [CEA, Gif-sur-Yvette; Eozenou, F. [CEA, Gif-sur-Yvette; Gasser, Y. [CEA, Gif-sur-Yvette; Visentin, B. [CEA, Gif-sur-Yvette; Clemens, William A. [JLAB; Geng, Rongli [JLAB; Manus, Robert [JLAB; Tyagi, Puneet [GUAS/AS, Ibaraki

2009-11-01

The Electro-Polishing (EP) process is the best candidate of final surface treatment for the production of ILC cavities. Nevertheless, the broad distribution of the gradient caused by field emitters in cavities is sitll a serious problem for the EP process. A candidate source of field emitter is the sulfur component which is produced in the EP process and remains the inner-surface of cavities. We studied the effect of Ethanole- and degreaser-rinse processes after the EP process by a unique method. Moreover, we tried to test the sponge cleaning as the post-EP process to remove the field emitter inside the cavcity. This article describe the results of series tests of the post-EP process at KEK.

Determination of Groundwater Velocity and Dispersion Parameters by Borehole Wall Multielectrode Geoelectrics

Science.gov (United States)

Kessels, W.; Wuttke, M. W.

2007-05-01

A single well technique to determine groundwater flow values and transport parameters is presented. Multielectrode arrays are placed at the filtered casing depth by an inflatable packer or are installed on the borehole wall behind the casing.Tracer water with a higher or lower specific electrical conductivity (salinity) which is injected between the electrodes. This tracer plume then moves into the natural groundwater flow field. The observation of this movement by geoelectric logging enables the determination of the groundwater velocity and salinity. The transport parameters "effective porosity" and "dispersion length" can also be derived. The geoelectric logging uses n borehole electrodes and two grounding electrodes. Thus, either n independent two point measurements or n*(n-1)/2 pole-to-pole measurements can be conducted to obtain a full set of geoelectric measurements. This set is used to derive all electrode combinations by applying the law of superposition and reciprocity. The tracer distribution around the borehole during and after injection depends on the hydraulic and transport parameters of the aquifer and the filter sand. The transport parameter "porosity" plus the total injected tracer volume determines the tracer distribution around the borehole. The transport parameter "dispersivity" determines the abruptness of the tracer front. The method was tested by undertaking measurements in a lab aquifer filled with sand. The results are discussed and the limitations of the method are shown. Multielectrode installations behind casing were tested in situ in the two scientific boreholes CAT-LUD-1 and CAT- LUD-1A drilled in the northern part of Germany. A multielectrode packer system was designed, built and tested in these boreholes. The results are compared with colloid observations in the borehole and hydraulic triangulation in surrounded observation wells. Here, the interpretation of these in situ measurements is mainly restricted to two point geoelectric

Aespoe Hard Rock Laboratory. BIPS logging in borehole KAS09

Energy Technology Data Exchange (ETDEWEB)

Gustafsson, Jaana; Gustafsson, Christer (Malaa Geoscience AB (Sweden))

2010-01-15

This report includes the data gained in BIPS logging performed at the Aespoe Hard Rock Laboratory. The logging operation presented here includes BIPS logging in the core drilled borehole KAS09. The objective for the BIPS logging was to observe the condition of KAS09 in order to restore the borehole in the hydrogeological monitoring programme.All measurements were conducted by Malaa Geoscience AB on October 9th 2009. The objective of the BIPS logging is to achieve information of the borehole including occurrence of rock types as well as determination of fracture distribution and orientation. This report describes the equipment used as well as the measurement procedures and data gained. For the BIPS survey, the result is presented as images. The basic conditions of the BIPS logging for geological mapping and orientation of structures are satisfying for borehole KAS09, although induced affects from the drilling on the borehole walls limit the visibility

Geostatistical Borehole Image-Based Mapping of Karst-Carbonate Aquifer Pores.

Science.gov (United States)

Sukop, Michael C; Cunningham, Kevin J

2016-03-01

Quantification of the character and spatial distribution of porosity in carbonate aquifers is important as input into computer models used in the calculation of intrinsic permeability and for next-generation, high-resolution groundwater flow simulations. Digital, optical, borehole-wall image data from three closely spaced boreholes in the karst-carbonate Biscayne aquifer in southeastern Florida are used in geostatistical experiments to assess the capabilities of various methods to create realistic two-dimensional models of vuggy megaporosity and matrix-porosity distribution in the limestone that composes the aquifer. When the borehole image data alone were used as the model training image, multiple-point geostatistics failed to detect the known spatial autocorrelation of vuggy megaporosity and matrix porosity among the three boreholes, which were only 10 m apart. Variogram analysis and subsequent Gaussian simulation produced results that showed a realistic conceptualization of horizontal continuity of strata dominated by vuggy megaporosity and matrix porosity among the three boreholes. © 2015, National Ground Water Association.

Aespoe Hard Rock Laboratory. BIPS logging in borehole KAS09

International Nuclear Information System (INIS)

Gustafsson, Jaana; Gustafsson, Christer

2010-01-01

This report includes the data gained in BIPS logging performed at the Aespoe Hard Rock Laboratory. The logging operation presented here includes BIPS logging in the core drilled borehole KAS09. The objective for the BIPS logging was to observe the condition of KAS09 in order to restore the borehole in the hydrogeological monitoring programme.All measurements were conducted by Malaa Geoscience AB on October 9th 2009. The objective of the BIPS logging is to achieve information of the borehole including occurrence of rock types as well as determination of fracture distribution and orientation. This report describes the equipment used as well as the measurement procedures and data gained. For the BIPS survey, the result is presented as images. The basic conditions of the BIPS logging for geological mapping and orientation of structures are satisfying for borehole KAS09, although induced affects from the drilling on the borehole walls limit the visibility

Initial Borehole Accelerometer Array Observations Near the North Portal of the ESF

International Nuclear Information System (INIS)

David von Seggern

2005-01-01

This report addresses observed ground motions at the site of the proposed surface facilities associated with the designated repository for high-level nuclear waste at Yucca Mountain, Nevada. In 2003 an accelerometer array was installed at three boreholes on the pad of the north portal of the ESF (Exploratory Studies Facility) at Yucca Mountain, Nevada, by the Nevada Seismological Laboratory (NSL). These boreholes, roughly 150 m apart and initially used for extensive geological and geophysical surveys, were ideal locations to measure the subsurface ground motions at the proposed site of surface facilities such as the Waste Handling Building. Such measurements will impact the design of the facilities. Accelerometer emplacement depths of approximately 15 m from the surface and then at the bottom of the boreholes, roughly 100 m, were chosen. Accelerometers were also placed at the surface next to the boreholes, for a total of nine accelerometers, all three-component. Data recording was accomplished with onsite recorders, with the onsite data transmitted to a central computer at a trailer on the pad. All requirements were met to qualify these data as ''Q''. Due to the lack of significant recordings during 2003, several low signal-to-noise (S/N) quality events were chosen for processing. The maximum horizontal peak ground acceleration (PGA) recorded at the pad was approximately 1 cm/s2 in 2003; the corresponding peak ground velocity (PGV) was approximately 0.01 cm/s. PGA and PGV were obtained at all nine accelerometers for most of these events, and spectra were computed. Ground motion amplitudes varied significantly across the boreholes. Higher ground amplifications were observed at the surface for the two boreholes that penetrated a thick amount (∼ 30 m) of fill and Quaternary alluvium compared to the one that had less than 2 m of such. Additionally, surface-to-deep recordings showed as much as a factor of five amplification at these two boreholes. Signal correlation

Relation between EPS adherence, viscoelastic properties, and MBR operation: Biofouling study with QCM-D.

Science.gov (United States)

Sweity, Amer; Ying, Wang; Ali-Shtayeh, Mohammed S; Yang, Fei; Bick, Amos; Oron, Gideon; Herzberg, Moshe

2011-12-01

Membrane fouling is one of the main constraints of the wide use of membrane bioreactor (MBR) technology. The biomass in MBR systems includes extracellular polymeric substances (EPS), metabolic products of active microbial secretion that adversely affect the membrane performance. Solids retention time (SRT) in the MBR is one of the most important parameters affecting membrane fouling in MBR systems, where fouling is minimized at optimal SRT. Among the operating parameters in MBR systems, SRT is known to strongly influence the ratio of proteins to polysaccharides in the EPS matrix. In this study, we have direct evidence for changes in EPS adherence and viscoelastic properties due to changes in the sludge removal rate that strongly correlate with the membrane fouling rate and EPS composition. EPS were extracted from a UF membrane in a hybrid growth MBR operated at sludge removal rates of 59, 35.4, 17.7, and 5.9 L day(-1) (corresponding SRT of 3, 5, 10, and 30 days, respectively). The EPS adherence and adsorption kinetics were carried out in a quartz crystal microbalance with dissipation monitoring (QCM-D) technology in several adsorption measurements to a gold sensor coated with Polyvinylidene Fluoride (PVDF). EPS adsorption to the sensor surface is characterized by a decrease of the oscillation frequency and an increase in the dissipation energy of the sensor during parallel flow of aqueous media, supplemented with EPS, above the sensor surface. The results from these experiments were further modeled using the Voigt based model, in which the thickness, shear modulus, and shear viscosity values of the adsorbed EPS layers on the PVDF crystal were calculated. The observations in the QCM-D suggested that the elevated fouling of the UF membrane is due to higher adherence of the EPS as well as reduction in viscosity and elasticity of the EPS adsorbed layer and elevation of the EPS fluidity. These results corroborate with confocal laser scanning microscopy (CLSM) image

Summary of the Lavia borehole investications in 1984

International Nuclear Information System (INIS)

Aeikaes, T.; Oehberg, A.; Ryhaenen, V.

1985-02-01

Industrial Power Company Ltd (TVO) drilled in the spring 1984 a 1001 m deep borehole, diameter 56 mm, in Lavia. The borehole is used during the years 1984-85 for developing and testing research methods and equipment needed in site investigations of spent fuel final disposal in the future. In 1984 hydraulical and geophysical tests were made and groundwater samples were taken. The drilling site is a wide outcropped area in the northern part of the porphyritic granite formation of Lavia. Geological and fracture mapping as well as geophysical measurements on the surface were made in the area surrounding the drilling site. The bedrock consists of homonous porphyritic granite, in which quartzdiorite occurs in thin incalations. Magnetic or electric anomalies were not observed. Fracture frequency is low and the fractures appear mainly in two sets. The rock types vary in the borehole from porphyritic granite to diorite. Due to slight mineralogical variations, the diorite is either granodiorite, quartzdiorite or tonalite. Granite occurs as veins. Hydraulic conductivity was measured systematically with a packer separation of 30 m between the depths 73-973 m. Hydraulic conductivity is generally 10 -10 -10 -11 m/s. Electric, radiometric, magnetic and acoustic measurements were made in the borehole. In addition, the caliper and the temperature of the borehole were measured. The results of these geophysical measurements indicate the properties of rock types and fracturing in the borehole. On the basis of the results e.g. fracture porosity was interpreted. The results of acoustic tube wave measurement correlate well with hydraulic conductivity. Water samples were taken from four depths. The deepest level was 910 m. The samples were taken with a packer separation of 5 m. In the water analyses it was observed that at several depths remarkable amounts of flushing water from drilling were still remaining in the rock

Aespoe Hard Rock Laboratory. Backfill and Plug test. Hydraulic testing of core drilled boreholes in the ZEDEX drift

Energy Technology Data Exchange (ETDEWEB)

Ludvigson, Jan-Erik; Nordqvist, Rune; Ekman, Lennart; Hansson, Kent (GEOSIGMA AB, Uppsala (Sweden))

2009-07-01

The present report documents the performance and results of hydraulic testing in selected core boreholes in the Zedex drift. The holes will be used as rock instrumentation boreholes during the Backfill and Plug Test at Aespoe HRL. The testing involves both 1 m long boreholes with 56 mm diameter as well as longer boreholes c. 5 m, 8 m and 25 m long with 56 mm or 76 mm diameter. Only single-hole tests were performed. The tests were carried out as short-time constant head injection tests since all boreholes tested (except one) were non-flowing before tests. The injection phase was followed by a pressure recovery phase. Furthermore, the tests were carried out as single-packer tests. A specially designed test system was used for the tests. The main evaluation of the tests was performed on data from the recovery phase by a new approach based on a non-linear regression technique combined with a flow simulation model (SUTRA). The tests in the 1 m-holes (testing the interval c. 0.3-0.7 m in the rock perpendicular to the tunnel face) show that the hydraulic conductivity of the superficial rock around the Zedex drift in general is low. However, during testing in some boreholes, visible leakage in the rock occurred through superficial fractures into the tunnel. These fractures were mainly located in the floor of the Zedex drift and are probably blast-induced. These fractures have a high hydraulic conductivity. The tests in the longer boreholes show that the hydraulic conductivity further into the rock in general is below c. 1x10-10 m/s. Increased hydraulic conductivity (c.1.5x10-8 m/s) was only observed in the flowing borehole KXZSD8HL.

Nuclear borehole logging for oil exploration

International Nuclear Information System (INIS)

Oelgaard, P.L.

1989-01-01

Reactor physics can be applied to the logging of boreholes for the exploration of oil and gas and the results obtained can be interpreted more correctly by use of reactor physics models, e.g. one-dimensional multi-group diffusion theory adapted for gamma quanta. The standard nuclear logging tools are: natural gamma, gamma density, neutron porosity and the pulsed-neutron tool. The models and interpretation procedures are discussed. 1 fig

Development of controlled drilling technology and measurement method in the borehole (Phase 1)

International Nuclear Information System (INIS)

Kiho, Kenzo; Shin, Koichi; Suzuki, Koichi; Miyakawa, Kimio; Okada, Tetsuji; Masuhara, Yasunobu; Igeta, Noriyuki; Kobayakawa, Hiroaki; Yamamoto, Shinya

2006-01-01

In Japan, the soft sedimentary rock of the Neogene tertiary is being focused as a host rock for High Level Waste (HLW) disposal. Especially, the soft sedimentary rock at the coastal area is thought to be one of the best candidates, since there is little driving force of the underground water. The measurement and logging of the bore hole in order to investigate the hydro-geological and geo-mechanical conditions of the host rock is a very important way to examine the potential of the disposal candidates. Central Research Institute of Electric Power Industry (CRIEPI) has been conducting the project on controlled drilling and the logging/measurement technologies in its boreholes. The key technologies of the project were defined as follows; (1) Drilling technology to bent the hole as intend. (2) Locality detection technology of the drill bit (MWD). (3) Core sampling technology to obtain the undisturbed rock core. (4) Logging and measurement technology during drilling. The drilling system and measuring system were integrated and systemized after each apparatus was manufactured and its performance was checked. The performance of the drilling system was checked to drill the artificial rock mass to the depth of 80 m before conducting in-situ drilling. The performance of the drilling and measurement systems were investigated to drill the mudstone of the Neogene Tertiary to the length of 547 m and to conduct the downhole measurement and logging in its borehole at the Horonobe site. Considering these performance testing, the flow diagram of the controlled drilling and measurement system was established. (author)

Pretest 3D finite element analysis of the WIPP Intermediate Scale Borehole Test

International Nuclear Information System (INIS)

Arguello, J.G.

1991-11-01

A three dimensional pretest finite element analysis of the Intermediate Scale Borehole Test has been performed. In the analysis, the 7.7 years simulation period includes the mining of Rooms C1 and C2, and the N1420 cross drift, at time zero; drilling of the borehole between the two rooms at 5.7 years; and 2 years of post-drilling response. An all salt configuration was used in the calculation. The 1984 Waste Isolation Pilot Plant (WIPP) reference elastic-secondary creep law, with reduced elastic moduli, was used to model the creeping response of the salt. Results show that after mining of the rooms and cross drift a relatively high von Mises stress state exists around the perimeter of the pillar. However, by 5.7 years, or immediately prior to drilling of the borehole, the pillar has relaxed to an almost uniform von Mises stress of about 7--8 MPa. After the borehole is drilled, a relatively high von Mises stress field is once again set up in the immediate vicinity of the hole. This drives the creep closure of the borehole. The hole closes more in the vertical direction than in the horizontal direction, resulting in ovalling of the hole. At the end of the simulation, the von Mises stress around the borehole is still higher than that in the remained of the pillar. Thus, the closure rates are relatively high at the end of the simulation time

Overexpression, purification, crystallization and preliminary X-ray studies of Vibrio cholerae EpsG

International Nuclear Information System (INIS)

Jens, Jason; Raghunathan, Kannan; Vago, Frank; Arvidson, Dennis

2009-01-01

Recombinant V. cholerae EpsG has been expressed, purified and crystallized. The crystals diffracted to 2.26 Å resolution. EpsG is the major pseudopilin protein of the Vibrio cholerae type II secretion system. An expression plasmid that encodes an N-terminally truncated form of EpsG with a C-terminal noncleavable His tag was constructed. Recombinant EpsG was expressed in Escherichia coli; the truncated protein was purified and crystallized by hanging-drop vapor diffusion against a reservoir containing 6 mM zinc sulfate, 60 mM MES pH 6.5, 15% PEG MME 550. The crystals diffracted X-rays to a resolution of 2.26 Å and belonged to space group P2 1 , with unit-cell parameters a = 88.61, b = 70.02, c = 131.54 Å

Epidermal growth factor pathway substrate 15, Eps15

DEFF Research Database (Denmark)

Salcini, A E; Chen, H; Iannolo, G

1999-01-01

Eps15 was originally identified as a substrate for the kinase activity of the epidermal growth factor receptor (EGFR). Eps15 has a tripartite structure comprising a NH2-terminal portion, which contains three EH domains, a central putative coiled-coil region, and a COOH-terminal domain containing...... multiple copies of the amino acid triplet Aspartate-Proline-Phenylalanine. A pool of Eps15 is localized at clathrin coated pits where it interacts with the clathrin assembly complex AP-2 and a novel AP-2 binding protein, Epsin. Perturbation of Eps15 and Epsin function inhibits receptor-mediated endocytosis...... of EGF and transferrin, demonstrating that both proteins are components of the endocytic machinery. Since the family of EH-containing proteins is implicated in various aspects of intracellular sorting, biomolecular strategies aimed at interfering with these processes can now be envisioned...

Key developments of the EP1000 design

International Nuclear Information System (INIS)

Noviello, L.

1999-01-01

In 1994, a group of European utilities initiated, together with Westinghouse and its industrial partner GENESI (an Italian consortium including ANSALDO and FIAT), a program designated EPP (European Passive Plant) to evaluate Westinghouse passive nuclear plant technology for application in Europe. The Phase I of the European Passive Plant program involved the evaluation of the Westinghouse 600 MWe AP600 and 1000 MWe Simplified Pressurized Water Reactor (SPWR) designs against the European Utility Requirements (EUR), and when necessary, the investigation of possible modifications to achieve compliance with the EUR. In Phase 1 of the program, which has been completed in 1996, the following major tasks were accomplished: The impacts of the European Utility Requirements (EUR) on the Westinghouse nuclear island design were evaluated. A 1000 MWe passive plant reference design (EP1000) was developed which conforms to the EUR and is expected to be licensable in Europe. With respect to the NSSS and containment, the EP1000 reference design closely follows those of the Westinghouse SPWR design, while the AP600 design has been taken as the basis for the design of the auxiliary systems. Extensive design and testing efforts have been made for the AP600 and SPWR during the respective multi-year programs. While the results of these programs have been and will continue to be utilised, at the maximum extent, to minimise the work to be performed on the EP1000 design, the compliance with EUR is a key design requirement for the EP1000 The ultimate objective of Phase 2 of the program is to develop design details and perform supporting analyses to produce a Safety Case Report (SCR) for submittal to European Safety Authorities. The first part of Phase 2, hereafter referred as Phase 2A, started at the beginning of 1997 and will be completed at the end of 1998. Scope of this phase of the program is to develop the design modifications of important systems and structures so to comply with the

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Science.gov (United States)

Seiler, Christoph; Gebhart, Nichole; Zhang, Yong; Shinton, Susan A; Li, Yue-sheng; Ross, Nicola L; Liu, Xingjun; Li, Qin; Bilbee, Alison N; Varshney, Gaurav K; LaFave, Matthew C; Burgess, Shawn M; Balciuniene, Jorune; Balciunas, Darius; Hardy, Richard R; Kappes, Dietmar J; Wiest, David L; Rhodes, Jennifer

2015-01-01

Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability of zebrafish make this a powerful model system for this purpose. We used a Tol2-based gene-breaking transposon to induce mutations in the zebrafish (Danio rerio, AB strain) genome, which served the dual purpose of fluorescently tagging cells and tissues that express the disrupted gene and provided a means of identifying the disrupted gene. We identified 12 lines in which hematopoietic tissues expressed green fluorescent protein (GFP) during embryonic development, as detected by microscopy. Subsequent analysis of young adult fish, using a novel approach in which single cell suspensions of whole fish were analyzed by flow cytometry, revealed that 8 of these lines also exhibited GFP expression in young adult cells. An additional 15 lines that did not have embryonic GFP+ hematopoietic tissue by microscopy, nevertheless exhibited GFP+ cells in young adults. RT-PCR analysis of purified GFP+ populations for expression of T and B cell-specific markers identified 18 lines in which T and/or B cells were fluorescently tagged at 6 weeks of age. As transposon insertion is expected to cause gene disruption, these lines can be used to assess the requirement for the disrupted genes in immune cell development. Focusing on the lines with embryonic GFP+ hematopoietic tissue, we identified three lines in which homozygous mutants exhibited impaired T cell development at 6 days of age. In two of the lines we identified the disrupted genes, agtpbp1 and eps15L1. Morpholino-mediated knockdown of these genes mimicked the T cell defects in the corresponding mutant embryos, demonstrating the previously unrecognized, essential roles of agtpbp1 and eps15L1 in T cell development.

Mutagenesis Screen Identifies agtpbp1 and eps15L1 as Essential for T lymphocyte Development in Zebrafish.

Directory of Open Access Journals (Sweden)

Christoph Seiler

Full Text Available Genetic screens are a powerful tool to discover genes that are important in immune cell development and function. The evolutionarily conserved development of lymphoid cells paired with the genetic tractability of zebrafish make this a powerful model system for this purpose. We used a Tol2-based gene-breaking transposon to induce mutations in the zebrafish (Danio rerio, AB strain genome, which served the dual purpose of fluorescently tagging cells and tissues that express the disrupted gene and provided a means of identifying the disrupted gene. We identified 12 lines in which hematopoietic tissues expressed green fluorescent protein (GFP during embryonic development, as detected by microscopy. Subsequent analysis of young adult fish, using a novel approach in which single cell suspensions of whole fish were analyzed by flow cytometry, revealed that 8 of these lines also exhibited GFP expression in young adult cells. An additional 15 lines that did not have embryonic GFP+ hematopoietic tissue by microscopy, nevertheless exhibited GFP+ cells in young adults. RT-PCR analysis of purified GFP+ populations for expression of T and B cell-specific markers identified 18 lines in which T and/or B cells were fluorescently tagged at 6 weeks of age. As transposon insertion is expected to cause gene disruption, these lines can be used to assess the requirement for the disrupted genes in immune cell development. Focusing on the lines with embryonic GFP+ hematopoietic tissue, we identified three lines in which homozygous mutants exhibited impaired T cell development at 6 days of age. In two of the lines we identified the disrupted genes, agtpbp1 and eps15L1. Morpholino-mediated knockdown of these genes mimicked the T cell defects in the corresponding mutant embryos, demonstrating the previously unrecognized, essential roles of agtpbp1 and eps15L1 in T cell development.

Search for excited electrons in ep collisions at HERA

Science.gov (United States)

H1 Collaboration; Aaron, F. D.; Alexa, C.; Andreev, V.; Antunovic, B.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Bacchetta, A.; Backovic, S.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Beckingham, M.; Begzsuren, K.; Behnke, O.; Belousov, A.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Cantun Avila, K. B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J. G.; Coughlan, J. A.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Daum, K.; Deák, M.; de Boer, Y.; Delcourt, B.; Del Degan, M.; Delvax, J.; de Roeck, A.; de Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eliseev, A.; Elsen, E.; Essenov, S.; Falkiewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Finke, L.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Grell, B. R.; Grindhammer, G.; Habib, S.; Haidt, D.; Hansson, M.; Helebrant, C.; Henderson, R. C. W.; Henschel, H.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Jacquet, M.; Janssen, M. E.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, A. W.; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knutsson, A.; Kogler, R.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Kutak, K.; Landon, M. P. J.; Lange, W.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Li, G.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martyn, H.-U.; Maxfield, S. J.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Mudrinic, M.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G. D.; Pejchal, O.; Peng, H.; Perez, E.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Plačakytė, R.; Polifka, R.; Povh, B.; Preda, T.; Radescu, V.; Rahmat, A. J.; Raicevic, N.; Raspiareza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Ruiz Tabasco, J. E.; Rurikova, Z.; Rusakov, S.; Salek, D.; Salvaire, F.; Sankey, D. P. C.; Sauter, M.; Sauvan, E.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R. N.; Sheviakov, I.; Shtarkov, L. N.; Shushkevich, S.; Sloan, T.; Smiljanic, I.; Smirnov, P.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Staykova, Z.; Steder, M.; Stella, B.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Toll, T.; Tomasz, F.; Tran, T. H.; Traynor, D.; Trinh, T. N.; Truöl, P.; Tsakov, I.; Tseepeldorj, B.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, K.; Valkárová, A.; Vallée, C.; van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; Wegener, D.; Wessels, M.; Wissing, Ch.; Wünsch, E.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y. C.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2008-08-01

A search for excited electrons is performed using the full ep data sample collected by the H1 experiment at HERA, corresponding to a total luminosity of 475 pb-1. The electroweak decays of excited electrons e→eγ, e→eZ and e→νW with subsequent hadronic or leptonic decays of the W and Z bosons are considered. No evidence for excited electron production is found. Mass dependent exclusion limits on e production cross sections and on the ratio f/Λ of the coupling to the compositeness scale are derived within gauge mediated models. These limits extend the excluded region compared to previous excited electron searches. The e production via contact interactions is also addressed for the first time in ep collisions.

Site characterization and validation - Borehole radar investigations stage 3

International Nuclear Information System (INIS)

Sandberg, E.; Olsson, O.; Falk, L.

1989-11-01

The borehole radar investigation program Stage 3 of the SCV-site has comprised single hole reflection measurements with centre frequencies of 22 and 60 MHz. Single hole reflection measurement with both omni-directional and directional antennas have been performed in the boreholes C1, C2, C3 and the D-holes. Crosshole tomographic measurements as well as cross- hole reflection measurement have been made between the bore- holes C1-C2, W1-C1 and W1-C2. The range obtained in the single hole reflection measurements was approximately 100 m for the lower frequency and about 60-70 m for the centre frequency 60 MHz. In the crosshole measurements transmitter-receiver separations from 20 to 120 m have been used. The Stage 3 radar investigations have essentially confirmed the three dimensional description of the structures at the SCV-site. The conceptual model of the site which was produced based on the Stage 1 data included three major zones, two minor zones and a circular feature. The major features are considered to be the most significant at the site and are all observed in the Stage 3 boreholes close to their predicted locations. The circular feature has also been found in two of the additional tomograms at the predicted location. The results indicate that the zones are not homogeneous but rather that they are highly irregular containing parts of considerably increased fracturing and parts where their contrast to the background rock is quite small. The zones appear to be approximately planar at least at the scale of the site. At a smaller scale the zones can appear quite irregular

Knowledge of Pre-exposure Prophylaxis (PrEP) for HIV Prevention Among Men Who Have Sex with Men in Denver, Colorado

Science.gov (United States)

Al-Tayyib, Alia A.; Thrun, Mark W.; Haukoos, Jason S.; Walls, N. Eugene

2014-01-01

As part of the National HIV Behavioral Surveillance System among men who have sex with men (MSM) in Denver, Colorado, we assessed knowledge of pre-exposure prophylaxis (PrEP); willingness to use PrEP; and potential changes in risk behaviors among HIV-negative participants reporting sexual activity with a male partner in the preceding 12 months. We examined knowledge of PrEP before (2008) and after (2011) results of the iPrEx trial were available. Of the 425 participants in the 2008 sample, 91 (21 %) were aware of PrEP compared to 131 (28 %) of the 461 participants in the 2011 sample (adjusted prevalence ratio: 1.43, 95 % confidence interval: 1.18, 1.72). Despite the increase in 2011, few MSM in Denver were aware of PrEP. Educating high-risk MSM about the potential utility of PrEP as an adjunct to other effective prevention methods is needed when considering the addition of PrEP to the HIV prevention arsenal. PMID:23824227

Drilling-induced borehole-wall damage at spent fuel test-climax

International Nuclear Information System (INIS)

Weed, H.C.; Durham, W.B.

1982-12-01

Microcracks in a sample of quartz monzonite from the Spent Fuel Test-Climax were measured by means of a scanning electron microscope in order to estimate the background level of damage near the borehole-wall. It appears that the hammer-drilling operation used to create the borehole has caused some microfracturing in a region 10 to 30 mm wide around the borehole. Beyond 30 mm, the level of microfracturing cannot be distinguished from background

Preliminary hydrogeologic assessment of boreholes UE-25c No. 1, UE-25c No. 2, and UE-25c No. 3, Yucca Mountain, Nye County, Nevada

International Nuclear Information System (INIS)

Geldon, A.L.

1993-01-01

The purpose of this report is to characterize the hydrogeology of saturated tuffaceous rocks penetrated by boreholes UE-25c No. 1, UE-25c No.2, and UE-25c No. 3. These boreholes are referred to collectively in this report as the C-holes. The C-holes were drilled to perform multiwell aquifer tests and tracer tests; they comprise the only complex of closely spaced boreholes completed in the saturated zone at Yucca Mountain. Results of lithologic and geophysical logging, fracture analyses, water-level monitoring, temperature and tracejector surveys, aquifer tests, and hydrochemical sampling completed at the C-hole complex as of 1986 are assessed with respect to the regional geologic and hydrologic setting. A conceptual hydrogeological model of the Yucca Mountain area is presented to provide a context for quantitatively evaluating hydrologic tests performed at the C-hole complex as of 1985, for planning and interpreting additional hydrologic tests at the C-hole complex, and for possibly re-evaluating hydrologic tests in boreholes other than the C-holes

Preliminary hydrogeologic assessment of boreholes UE-25c No. 1, UE-25c No. 2, and UE-25c No. 3, Yucca Mountain, Nye County, Nevada

International Nuclear Information System (INIS)

Geldon, A.L.

1993-01-01

The purpose of this report is to characterize-the hydrogeology of saturated tuffaceous rocks penetrated by boreholes UE-25c number-sign 1, UE-25c number-sign 2, and UE-25c number-sign 3. These boreholes are referred to collectively in this report as the C-holes. The C-holes were drilled to perform multiwell aquifer tests and tracer tests; they comprise the only complex of closely spaced boreholes completed in the saturated zone at Yucca Mountain. Results of lithologic and geophysical logging, fracture analyses, water-level monitoring, temperature and tracejector surveys aquifer tests, and hydrochemical sampling completed at the C-hole complex as of 1986 are assessed with respect to the regional geologic and hydrologic setting. A conceptual hydrogeological model of the Yucca Mountain area is presented to provide a context for quantitatively evaluating hydrologic tests performed at the C-hole complex as of 1985, for planning and interpreting additional hydrologic tests at the C-hole complex, and for possibly re-evaluating hydrologic tests in boreholes other than the C-holes

Prostaglandin E2 stimulates Fas ligand expression via the EP1 receptor in colon cancer cells.

LENUS (Irish Health Repository)

O'Callaghan, G

2012-02-03

Fas ligand (FasL\\/CD95L) is a member of the tumour necrosis factor superfamily that triggers apoptosis following crosslinking of the Fas receptor. Despite studies strongly implicating tumour-expressed FasL as a major inhibitor of the anti-tumour immune response, little is known about the mechanisms that regulate FasL expression in tumours. In this study, we show that the cyclooxygenase (COX) signalling pathway, and in particular prostaglandin E(2) (PGE(2)), plays a role in the upregulation of FasL expression in colon cancer. Suppression of either COX-2 or COX-1 by RNA interference in HCA-7 and HT29 colon tumour cells reduced FasL expression at both the mRNA and protein level. Conversely, stimulation with PGE(2) increased FasL expression and these cells showed increased cytotoxicity against Fas-sensitive Jurkat T cells. Prostaglandin E(2)-induced FasL expression was mediated by signalling via the EP1 receptor. Moreover, immunohistochemical analysis using serial sections of human colon adenocarcinomas revealed a strong positive correlation between COX-2 and FasL (r=0.722; P<0.0001) expression, and between EP1 receptor and FasL (r=0.740; P<0.0001) expression, in the tumour cells. Thus, these findings indicate that PGE(2) positively regulates FasL expression in colon tumour cells, adding another pro-neoplastic activity to PGE(2).

Influence of extracellular polymeric substances (EPS) on Cd adsorption by bacteria

Energy Technology Data Exchange (ETDEWEB)

Wei Xing [State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070 (China); Fang Linchuan [Key Laboratory of Subtropical Agricultural Resources and Environment, Ministry of Agriculture, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070 (China); Cai Peng, E-mail: cp@mail.hzau.edu.cn [State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070 (China); Key Laboratory of Subtropical Agricultural Resources and Environment, Ministry of Agriculture, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070 (China); Huang Qiaoyun [State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070 (China); Key Laboratory of Subtropical Agricultural Resources and Environment, Ministry of Agriculture, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070 (China); Chen Hao [College of Science, Huazhong Agricultural University, Wuhan 430070 (China); Liang Wei; Rong, Xinming [Key Laboratory of Subtropical Agricultural Resources and Environment, Ministry of Agriculture, College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070 (China)

2011-05-15

The role of extracellular polymeric substances (EPS) in Cd adsorption by Bacillus subtilis and Pseudomonas putida was investigated using a combination of batch adsorption experiments, potentiometric titrations, Fourier transform infrared spectroscopy (FTIR). An increased adsorption capacity of Cd was observed for untreated bacteria relative to that for EPS-free bacteria. Surface complexation modeling of titration data showed the similar pK{sub a} values of functional groups (carboxyl, phosphate and hydroxyl) between untreated and EPS-free bacteria. However, site concentrations on the untreated bacteria were found to be higher than those on the EPS-free bacteria. FTIR spectra also showed that no significant difference in peak positions was observed between untreated and EPS-free bacteria and carboxyl and phosphate groups were responsible for Cd adsorption on bacterial cells. The information obtained in this study is of fundamental significance for understanding the interaction mechanisms between heavy metals and biofilms in natural environments. - Highlights: > The presence of EPS on bacterial surfaces facilitates the adsorption of Cd. > The promoting effects on Cd adsorption are more remarkable on Gram-positive B. subtilis cells than that on Gram-negative P. putida cells. > Carboxyl and phosphate groups are mostly responsible for Cd binding on untreated and EPS-free cells. > Intact bacterial cells and EPS-free cells have similar binding mechanisms for Cd. - Intact bacterial cells and EPS-free cells have similar binding mechanisms for Cd.

EpCAM as multi-tumour target for near-infrared fluorescence guided surgery

International Nuclear Information System (INIS)

Driel, P. B. A. A. van; Boonstra, M. C.; Prevoo, H. A. J. M.; Giessen, M. van de; Snoeks, T. J. A.; Tummers, Q. R. J. G.; Keereweer, S.; Cordfunke, R. A.; Fish, A.; Eendenburg, J. D. H. van; Lelieveldt, B. P. F.; Dijkstra, J.; Velde, C. J. H. van de; Kuppen, P. J. K.; Vahrmeijer, A. L.; Löwik, C. W. G. M.; Sier, C. F. M.

2016-01-01

Evaluation of resection margins during cancer surgery can be challenging, often resulting in incomplete tumour removal. Fluorescence-guided surgery (FGS) aims to aid the surgeon to visualize tumours and resection margins during surgery. FGS relies on a clinically applicable imaging system in combination with a specific tumour-targeting contrast agent. In this study EpCAM (epithelial cell adhesion molecule) is evaluated as target for FGS in combination with the novel Artemis imaging system. The NIR fluorophore IRDye800CW was conjugated to the well-established EpCAM specific monoclonal antibody 323/A3 and an isotype IgG1 as control. The anti-EpCAM/800CW conjugate was stable in serum and showed preserved binding capacity as evaluated on EpCAM positive and negative cell lines, using flow cytometry and cell-based plate assays. Four clinically relevant orthotopic tumour models, i.e. colorectal cancer, breast cancer, head and neck cancer, and peritonitis carcinomatosa, were used to evaluate the performance of the anti-EpCAM agent with the clinically validated Artemis imaging system. The Pearl Impulse small animal imaging system was used as reference. The specificity of the NIRF signal was confirmed using bioluminescence imaging and green-fluorescent protein. All tumour types could clearly be delineated and resected 72 h after injection of the imaging agent. Using NIRF imaging millimetre sized tumour nodules were detected that were invisible for the naked eye. Fluorescence microscopy demonstrated the distribution and tumour specificity of the anti-EpCAM agent. This study shows the potential of an EpCAM specific NIR-fluorescent agent in combination with a clinically validated intraoperative imaging system to visualize various tumours during surgery

Dimensioning of Boreholes for Geothermal Heat Pumps

Directory of Open Access Journals (Sweden)

Ryška Jiøí

2004-09-01

Full Text Available The paper deals with determination of borehole depths for geothermal heat pumps. Basic formulae are stated for heat convection in rocks. Software EED 2.0 was used for calculation of borehole depth depending on different entering parameters. The crucial parameter is thermal conductivity of rocks. The thermal conductivity could be very variable for the same kind of rock. Therefore its in-situ determination by means of formation thermal conductivity testing is briefly described.

Digital signal processing of data from borehole creep closure

International Nuclear Information System (INIS)

Chakrabarti, S.; Patrick, W.C.; Duplancic, N.

1987-01-01

Digital signal processing, a technique commonly used in the fields of electrical engineering and communication technology, has been successfully used to analyze creep closure data obtained from a 0.91 m diameter by 5.13 deep borehole in bedded salt. By filtering the ''noise'' component of the closure data from a test borehole, important data trends were made more evident and average creep closure rates were able to be calculated. This process provided accurate estimates of closure rates that are used in the design of lined boreholes in which heat-generating transuranic nuclear wastes are emplaced at the Waste Isolation Pilot Plant

Exopolysaccharides (EPS) as anti-corrosive additives for coatings

NARCIS (Netherlands)

Scheerder, J.; Breur, R.; Slaghek, T.; Holtman, W.; Vennik, M.; Ferrari, G.

2012-01-01

Exopolysaccharides (EPS) are a class of renewable polymers that show interesting anti-corrosive properties and could potentially be used as an alternative for zinc phosphates. When combined with a waterborne styrene-acrylic polymer dispersion (SA-1), exopolysaccharides were shown to give an

Geophysical borehole logging of the boreholes KR37, KR37B and KR38, at Olkiluoto 2005

International Nuclear Information System (INIS)

Majapuro, J.

2006-03-01

Suomen Malmi Oy conducted geophysical borehole logging of the boreholes KR37, KR37b and KR38 at the Olkiluoto site in Eurajoki during September and October 2005. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and processing of the acoustic data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Heavy Quark Production in ep Collisions at HERA

International Nuclear Information System (INIS)

Bloch, I.

2006-01-01

Collisions of electrons with protons at a centre-of-mass energy of 318 GeV are being recorded by the two experiments H1 and ZEUS at the ep accelerator HERA at DESY, Hamburg (Germany). Measurements involving beauty and charm quarks, performed by these experiments, provide a good environment to test perturbative QCD predictions as the large quark mass supplies a hard scale. Recent measurements of beauty and charm production in ep collisions are presented here. QCD predictions at next-to-leading order are found to generally agree with the measurements. Beauty measurements however are sometimes slightly higher than the predicted cross sections. Beauty and charm contributions to the proton structure were also measured and are well described by QCD predictions

The Pre-Exposure Prophylaxis-Stigma Paradox: Learning from Canada's First Wave of PrEP Users.

Science.gov (United States)

Grace, Daniel; Jollimore, Jody; MacPherson, Paul; Strang, Matthew J P; Tan, Darrell H S

2018-01-01

With the emergence of daily oral tenofovir disoproxil fumarate and emtricitabine-based pre-exposure prophylaxis (PrEP) use in Canada, questions have emerged concerning the impacts of this HIV prevention tool on gay men's social and sexual lives. We conducted small focus groups and individual qualitative interviews with 16 gay men in Toronto who were part of the 'first wave' of Canadian PrEP users. Participants were on PrEP for at least one year as part of a demonstration project (November 2014-June 2016). These participants accessed PrEP before regulatory approval by Health Canada in February 2016. The mean age of participants was 37.6 years (SD 11.02); 94% completed secondary education, and 69% were white. Sex-stigma emerged as a complex theme in men's accounts of PrEP use across three overlapping domains: (1) PrEP-related stigma, including discussions of concealment and stigma from friends, family, and sexual partners, (2) PrEP as a perceived tool for combating HIV-related stigma, where some men said that they no longer discussed HIV status with sexual partners, and (3) PrEP as illuminating structural stigma, where it was attributed to unmasking stigma related to sex and sexuality. For some participants, PrEP has allowed for liberating sex and a self-described return to normalcy-normal, exciting, pleasurable sex that was no longer reliant on condom use. Paradoxically, some men said that PrEP use both led them to experience stigmatizing reactions within their social and sexual networks, while also helping to remove stigma, shame, and fear related to HIV, sexuality, and sex with gay men living with HIV.

OMEGA EP: High-Energy Petawatt Capability for the OMEGA Laser Facility

International Nuclear Information System (INIS)

Kelly, J.H.; Waxer, L.J.; Bagnoud, V.; Begishev, I.A.; Bromage, J.; Kruschwitz, B.E.; Kessler, T.J.; Loucks, S.J.; Maywar, D.N.; McCrory, R.L.; Meyerhofer, D.D.; Morse, S.F.B.; Oliver, J.B.; Rigatti, A.L.; Schmid, A.W.; Stoeckl, C.; Dalton, S.; Folnsbee, L.; Guardalben, M.J.; Jungquist, R.; Puth, J.; Shoup III, M.J.; Weiner, D.; Zuegel, J.D.

2006-01-01

OMEGA EP (Extended Performance) is a petawatt-class addition to the existing 30-kJ, 60-beam OMEGA Laser Facility at the University of Rochester. When completed, it will consist of four beamlines, each capable of producing up to 6.5 kJ at 351 nm in a 1 to 10 ns pulse. Two of the beamlines will produce up to 2.6 kJ in a pulse-width range of 1 to 100 ps at 1053 nm using chirped-pulse amplification (CPA). This paper reviews both the OMEGA EP performance objectives and the enabling technologies required to meet these goals

e-EPS News: Light for Development

CERN Multimedia

e-EPS

2011-01-01

e-EPS News is a monthly addition to the CERN Bulletin line-up, showcasing articles by the e-EPS – the European Physical Society newsletter – as part of a collaboration between the two publications.   A central goal of the EPS International Year of Light project will be to promote optical technologies and optics education to improve the quality of life in the developing world – under the theme of ‘Light for Development’. Light plays a central role in human activities in science, technology and culture. On a fundamental scientific level, light is necessary for the existence of life itself, whilst on a more technical level, light-based technologies will underpin the future development of human society. The systematic study of the physics of light and electromagnetic waves has been central to the evolution of modern science and – in the 20th century alone – there have been many fundamental ...

Re-sampling of the KLX02 deep borehole at Laxemar

International Nuclear Information System (INIS)

Laaksoharju, M.; Andersson, Cecilia; Tullborg, E.L.; Wallin, B.; Ekwall, K.; Pedersen, K.

1999-01-01

The project focuses on the origin and changes of deep groundwaters, which are important for understanding the stability of the groundwater surrounding the final repository. The results from the sampling campaign in 1997 down to a depth of 1500m are compared with the results from 1993 sampled in the same borehole. The analytical results and some preliminary calculations are presented. The changes since the last sampling campaign 4 years ago indicate a high degree of mixing and dynamics in the system. The following conclusions are drawn: More changes in the water composition than expected compared with the results from the sampling campaign in 1993; Larger portions of meteoric water in the upper part of the borehole; Less glacial water in the intermediate part of the borehole; More brine water in the lower part of the borehole. The conclusion is that there has been a relatively large change in the groundwater system during the last 4 years in the Laxemar deep borehole. The disturbance removed the effect from the last glaciation and pulled in groundwater, which resulted in a mixture mainly consisting of meteoric and brine waters. The most probable reason is that the annual fluctuation and flow in the open borehole play an important role as a modificator especially for the isotopes. The results show the sensitivity of deep groundwater to changes in the prevailing hydrogeological situation

Numerical Borehole Breakdown Investigations using XFEM

Science.gov (United States)

Beckhuis, Sven; Leonhart, Dirk; Meschke, Günther

2016-04-01

During pressurization of a wellbore a typical downhole pressure record shows the following regimes: first the applied wellbore pressure balances the reservoir pressure, then after the compressive circumferential hole stresses are overcome, tensile stresses are induced on the inside surface of the hole. When the magnitude of these stresses reach the tensile failure stress of the surrounding rock medium, a fracture is initiated and propagates into the reservoir. [1] In standard theories this pressure, the so called breakdown pressure, is the peak pressure in the down-hole pressure record. However experimental investigations [2] show that the breakdown did not occur even if a fracture was initiated at the borehole wall. Drilling muds had the tendency to seal and stabilize fractures and prevent fracture propagation. Also fracture mechanics analysis of breakdown process in mini-frac or leak off tests [3] show that the breakdown pressure could be either equal or larger than the fracture initiation pressure. In order to gain a deeper understanding of the breakdown process in reservoir rock, numerical investigations using the extended finite element method (XFEM) for hydraulic fracturing of porous materials [4] are discussed. The reservoir rock is assumed to be pre-fractured. During pressurization of the borehole, the injection pressure, the pressure distribution and the position of the highest flux along the fracture for different fracturing fluid viscosities are recorded and the influence of the aforementioned values on the stability of fracture propagation is discussed. [1] YEW, C. H. (1997), "Mechanics of Hydraulic Fracturing", Gulf Publishing Company [2] MORITA, N.; BLACK, A. D.; FUH, G.-F. (1996), "Borehole Breakdown Pressure with Drilling Fluids". International Journal of Rock Mechanics and Mining Sciences 33, pp. 39-51 [3] DETOURNAY, E.; CARBONELL, R. (1996), "Fracture Mechanics Analysis of the Breakdown Process in Minifrac or Leakoff Test", Society of Petroleum

Determination of subsurface geological structure with borehole gravimetry

International Nuclear Information System (INIS)

Clark, S.R.; Hearst, J.R.

1983-07-01

Conventional gamma-gamma and gravimetric density measurements are routinely gathered for most holes used for underground nuclear tests. The logs serve to determine the subsurface structural geology near the borehole. The gamma-gamma density log measures density of the rock within about 15 cm of the borehole wall. The difference in gravity measured at two depths in a borehole can be interpreted in terms of the density of an infinite, homogeneous, horizontal bed between those depths. When the gravimetric density matches the gamma-gamma density over a given interval it is assumed that the bed actualy exists, and that rocks far from the hole must be the same as those encountered adjacent to the borehole. Conversely, when the gravimetric density differs from the gamma-gamma density it is apparent that the gravimeter is being influenced by a rock mass of different density than that at the hole wall. This mismatch can be a powerful tool to deduce the local structural geology. The geology deduced from gravity mesurements in emplacement hole, U4al, and the associated exploratory hole, UE4al, is an excellent example of the power of the method

Electromagnetic fields in cased borehole

International Nuclear Information System (INIS)

Lee, Ki Ha; Kim, Hee Joon; Uchida, Toshihiro

2001-01-01

Borehole electromagnetic (EM) measurements, using fiberglass-cased boreholes, have proven useful in oil field reservoir characterization and process monitoring (Wilt et al., 1995). It has been presumed that these measurements would be impossible in steel-cased wells due to the very large EM attenuation and phase shifts. Recent laboratory and field studies have indicated that detection of EM signals through steel casing should be possible at low frequencies, and that these data provide a reasonable conductivity image at a useful scale. Thus, we see an increased application of this technique to mature oilfields, and an immediate extension to geothermal industry as well. Along with the field experiments numerical model studies have been carried out for analyzing the effect of steel casing to the EM fields. The model used to be an infinitely long uniform casing embedded in a homogeneous whole space. Nevertheless, the results indicated that the formation signal could be accurately recovered if the casing characteristics were independently known (Becker et al., 1998; Lee el al., 1998). Real steel-cased wells are much more complex than the simple laboratory models used in work to date. The purpose of this study is to develop efficient numerical methods for analyzing EM fields in realistic settings, and to evaluate the potential application of EM technologies to cross-borehole and single-hole environment for reservoir characterization and monitoring

Preparing for the Rollout of Pre-Exposure Prophylaxis (PrEP: A Vignette Survey to Identify Intended Sexual Behaviors among Women in Kenya and South Africa if Using PrEP.

Directory of Open Access Journals (Sweden)

Amy Corneli

Full Text Available Several clinical trials have demonstrated the efficacy of pre-exposure prophylaxis (PrEP in reducing HIV risk. One concern with introducing PrEP is whether users will engage in riskier sexual behaviors.We assessed the effect that PrEP may have on sexual risk behaviors by administering a survey to 799 women in Bondo, Kenya, and Pretoria, South Africa. Participants were asked about their sexual behavior intentions twice--once as if they were taking PrEP and once as if they were not taking PrEP--within four risk situations (vignettes. They responded using a 5-point ordinal scale. We used a series of linear mixed effects models with an unstructured residual covariance matrix to estimate the between- and within-subject differences in the mean likelihood of engaging in risky sexual behavior across the PrEP and non-PrEP contexts. We also calculated the total percentage of participants who reported a greater likelihood of engaging in risky sexual behavior if taking PrEP than if not taking PrEP, by vignette.We found statistically significant differences in the mean likelihood of engaging in risky sexual behavior with the between-subject comparison (-0.17, p < 0.01 and with the within-subject comparison (-0.31, p < 0.001. Depending on the vignette, 27% to 40% of participants reported a greater likelihood of engaging in risky sexual behavior if taking PrEP than if not taking PrEP.Our findings indicate that modest increases in risky sexual behavior could occur with PrEP. Although responses from the majority of participants suggest they would not be more likely to engage in risky sexual behavior if they took PrEP, a substantial proportion might. Programs rolling out PrEP should be prepared to assist similar women in making informed choices about reducing their risk of HIV and about their sexual health beyond HIV prevention.

NREL- and Sandia-Developed HyStEP Device Receives Far West FLC Award | News

Science.gov (United States)

| NREL NREL- and Sandia-Developed HyStEP Device Receives Far West FLC Award NREL- and Sandia -Developed HyStEP Device Receives Far West FLC Award September 1, 2016 The National Renewable Energy technologies and boost the regional economy. As FLC awards are granted for outstanding achievements in

Method and apparatus for logging a borehole employing dual radiation detectors

International Nuclear Information System (INIS)

Arnold, D.M.

1986-01-01

An apparatus is described for logging a characteristic of a borehole in an earth formation employing nuclear count rate data selectively compensated for non-standard borehole conditions, comprising: a sonde, movable in a borehole, having: a radiation source for emitting radiation into earth formations adjacent the wellbore; first detector, spaced longitudinally from the radiation source, for detecting radiation scattered back to the detector and generating a first signal representative of a first count rate value, C/sub SS/; and second detector spaced a different longitudinal distance from the radiation source, for detecting radiation scattered back to the detector and generating a second signal representative of a count rate value, C/sub LS/; memory means for storing a predetermined threshold value, first predetermined relationships between the borehole characteristic and count rate values C/sub LS/, C/sub SS/; and second predetermined relationships between the borehole characteristic and ratios of C/sub LS/ to C/sub SS/; electronic means for producing a signal related in value to the borehole characteristic, which electronic means compares at least one of the first and second count rate value signals with the predetermined threshold value; means for recording the signal generated by the electronic means

Methane oxidation and formation of EPS in compost: effect of oxygen concentration

International Nuclear Information System (INIS)

Wilshusen, J.H.; Hettiaratchi, J.P.A.; Visscher, A. de; Saint-Fort, R.

2004-01-01

Oxygen concentration plays an important role in the regulation of methane oxidation and the microbial ecology of methanotrophs. However, this effect is still poorly quantified in soil and compost ecosystems. The effect of oxygen on the formation of exopolymeric substances (EPS) is as yet unknown. We studied the effect of oxygen on the evolution of methanotrophic activity. At both high and low oxygen concentrations, peak activity was observed twice within a period of 6 months. Phospholipid fatty acid analysis showed that there was a shift from type I to type II methanotrophs during this period. At high oxygen concentration, EPS production was about 250% of the amount at low oxygen concentration. It is hypothesized that EPS serves as a carbon cycling mechanism for type I methanotrophs when inorganic nitrogen is limiting. Simultaneously, EPS stimulates nitrogenase activity in type II methanotrophs by creating oxygen-depleted zones. The kinetic results were incorporated in a simulation model for gas transport and methane oxidation in a passively aerated biofilter. Comparison between the model and experimental data showed that, besides acting as a micro-scale diffusion barrier, EPS can act as a barrier to macro-scale diffusion, reducing the performance of such biofilters. - 1.5% oxygen resulted in a slightly higher and more stable methane oxidation activity

Methods for use in detecting seismic waves in a borehole

Science.gov (United States)

West, Phillip B.; Fincke, James R.; Reed, Teddy R.

2007-02-20

The invention provides methods and apparatus for detecting seismic waves propagating through a subterranean formation surrounding a borehole. In a first embodiment, a sensor module uses the rotation of bogey wheels to extend and retract a sensor package for selective contact and magnetic coupling to casing lining the borehole. In a second embodiment, a sensor module is magnetically coupled to the casing wall during its travel and dragged therealong while maintaining contact therewith. In a third embodiment, a sensor module is interfaced with the borehole environment to detect seismic waves using coupling through liquid in the borehole. Two or more of the above embodiments may be combined within a single sensor array to provide a resulting seismic survey combining the optimum of the outputs of each embodiment into a single data set.

Prospects of the future ep colliders

International Nuclear Information System (INIS)

Alekhin, S.I.; Boos, Eh.Eh.; Borodulin, V.I.; Dzhikiya, G.V.; Slabospitskij, S.R.; Smirnov, A.Yu.; Sultanov, S.F.

1987-01-01

The possibilities of ep colliders with √=1.1 and 2.4 TeV to investigate new physics at the l∼10 -17 cm have been considered. UNK with linear electron accelerator enables to investigate the mechanism of spontaneous symmetry breaking in the standard model, interactions conditioned by new gauge bosons, the properties if excited leptons and quarks of the first family, the structure of contact interactions, predicted by preon models, the properties of SUSY-partners of electrons and light quarks

Slepton and squark production and decay in ep collision at the LHC

International Nuclear Information System (INIS)

Bartl, A.; Majerotto, W.; Oshimo, N.; Moesslacher, B.

1991-06-01

We present a detailed study of e+p → e+q+X and e+p → v+q+X and the subsequent decays of e,v, and q at the LHC (√s = 1.4 TeV). We explore the relevant supersymmetry parameter range. We calculate the cross section as well as the rates for interesting signatures such as the production of one or two leptons on the lepton side. (authors)

Long term monitoring of water production flow rates in boreholes in the Callovo-Oxfordian argillaceous rock

International Nuclear Information System (INIS)

Vinsot, A.; Delay, J.; La Vaissiere, R. de; Cruchaudet, M.

2010-01-01

Document available in extended abstract form only. Water production was observed in several boreholes in the Callovo-Oxfordian argillaceous rock (COx). These boreholes were implemented in 2005 in the Andra's Underground Research Laboratory (URL) at more than 400 m in depth. Despite the low COx permeability: close to 10-13 m/s, two original experimental setups made it possible to monitor water production flow rates ranging from 0.5 to 50 mL/day during 3 to 4 years in 4 boreholes. This contribution describes the water flow rate evaluation methods and the results obtained from several experimental phases which may be considered as a series of constant pressure production tests. The first experimental concept was based on seepage water collection. It consisted in filling with gas the interval of an ascending borehole at a pressure close to 1 bar and closing it. The hydraulic pressure in the rock surrounding the sealed interval was higher than 30 bars. Due to the hydraulic pressure difference between the interval and the surrounding rock, the interstitial water of the formation flowed into the interval, accumulated at its base by gravity and was pumped out at a controlled flow rate. The pumping rate was adjusted so that the water level would not exceed 40 cm inside the 5-meter-long interval. The water level was deduced from the difference between two absolute pressure measurements: one above the water surface in the gas phase and the other at the bottom of the water column. The total volume of the daily produced formation water was obtained by adding the water volume pumped out during the day and the water volume difference inside the interval between the beginning and the end of the day. This kind of experiment was performed in two boreholes. The second experimental concept was based on water circulation. It consisted in filling with water the interval of a descending borehole. Two water circulation lines and one pressure control line linked the test interval to

Characterization of earthquake fault by borehole experiments; Koseinai sokutei ni yoru jishin danso no kenshutsu

Energy Technology Data Exchange (ETDEWEB)

Ito, H; Miyazaki, T; Nishizawa, O; Kuwahara, Y; Kiguchi, T [Geological Survey of Japan, Tsukuba (Japan)

1996-05-01

A borehole was excavated to penetrate the Nojima fault at the Hirabayashi area, to investigate the underground structures of the fault by observation of the cores and well logging. The borehole was excavated from 74.6m east of the fault surface. Soil is of granodiorite from the surface, and fault clay at a depth in a range from 624.1 to 625.1m. Observation of the cores, collected almost continuously, indicates that the fault fracture zone expands in a depth range from 557 to 713.05m. The well logging experiments are natural potential, resistivity, density, gamma ray, neutron, borehole diameter, microresistivity and temperature. They are also for DSI- and FMI-observation, after expansion of the borehole. The well logging results indicate that resistivity, density and elastic wave velocity decrease as distance from fault clay increases, which well corresponds to the soil conditions. The BHTV and FMI analyses clearly detect the fault clay demarcations, and show that elastic wave velocity and BHTV results differ at above and below the fault. 3 refs., 3 figs.

Permeameter studies of water flow through cement and clay borehole seals in granite, basalt and tuff

International Nuclear Information System (INIS)

South, D.L.; Daemen, J.J.K.

1986-10-01

Boreholes near a repository must be sealed to prevent rapid migration of radionuclide-contaminated water to the accessible environment. The objective of this research is to assess the performance of borehole seals under laboratory conditions, particularly with regard to varying stress fields. Flow through a sealed borehole is compared with flow through intact rock. Cement or bentonite seals have been tested in granite, basalt, and welded tuff. The main conclusion is that under laboratory conditions, existing commercial materials can form high quality seals. Triaxial stress changes about a borehole do not significantly affect seal performance if the rock is stiffer than the seal. Temperature but especially moisture variations (drying) significantly degrade the quality of cement seals. Performance partially recovers upon resaturation. A skillfully sealed borehole may be as impermeable as the host rock. Analysis of the influence of relative seal-rock permeabilities shows that a plug with permeability one order of magnitude greater than that of the rock results in a flow increase through the hole and surrounding rock of only 1-1/2 times compared to the undisturbed rock. Since a borehole is only a small part of the total rock mass, the total effect is even less pronounced. The simplest and most effective way to decrease flow through a rock-seal system is to increase the seal length, assuming it can be guaranteed that no dominant by-pass flowpath through the rock exists

Permeameter studies of water flow through cement and clay borehole seals in granite, basalt and tuff

Energy Technology Data Exchange (ETDEWEB)

South, D.L.; Daemen, J.J.K.

1986-10-01

Boreholes near a repository must be sealed to prevent rapid migration of radionuclide-contaminated water to the accessible environment. The objective of this research is to assess the performance of borehole seals under laboratory conditions, particularly with regard to varying stress fields. Flow through a sealed borehole is compared with flow through intact rock. Cement or bentonite seals have been tested in granite, basalt, and welded tuff. The main conclusion is that under laboratory conditions, existing commercial materials can form high quality seals. Triaxial stress changes about a borehole do not significantly affect seal performance if the rock is stiffer than the seal. Temperature but especially moisture variations (drying) significantly degrade the quality of cement seals. Performance partially recovers upon resaturation. A skillfully sealed borehole may be as impermeable as the host rock. Analysis of the influence of relative seal-rock permeabilities shows that a plug with permeability one order of magnitude greater than that of the rock results in a flow increase through the hole and surrounding rock of only 1-1/2 times compared to the undisturbed rock. Since a borehole is only a small part of the total rock mass, the total effect is even less pronounced. The simplest and most effective way to decrease flow through a rock-seal system is to increase the seal length, assuming it can be guaranteed that no dominant by-pass flowpath through the rock exists.

Automated borehole gravity meter system

International Nuclear Information System (INIS)

Lautzenhiser, Th.V.; Wirtz, J.D.

1984-01-01

An automated borehole gravity meter system for measuring gravity within a wellbore. The gravity meter includes leveling devices for leveling the borehole gravity meter, displacement devices for applying forces to a gravity sensing device within the gravity meter to bring the gravity sensing device to a predetermined or null position. Electronic sensing and control devices are provided for (i) activating the displacement devices, (ii) sensing the forces applied to the gravity sensing device, (iii) electronically converting the values of the forces into a representation of the gravity at the location in the wellbore, and (iv) outputting such representation. The system further includes electronic control devices with the capability of correcting the representation of gravity for tidal effects, as well as, calculating and outputting the formation bulk density and/or porosity

Borehole instrument for scintillation gamma spectrometer

International Nuclear Information System (INIS)

Sinitsyn, A.Ya.; Gabitov, R.M.

1979-01-01

Described are a schematic diagram and main specifications of a borehole instrument with autostabilization of energy scale measure by gamma bench-mark of 137 Cs, intended for the application in a logging gamma spectrometer to determine separately the concentrations of nature radioactive elements. The instrument may be connected to the KOBDFM-2 cable of 600 m length. It contains a scintillation counter for gamma quanta consisting of 30x70 mm NaI(Tl) crystal and a FEU-85 photoamplifier, an input conforming stage, a diagram of threshold pulse formation and regulating high-voltage generator. The borehole instrument has been proved under laboratory and field conditions at 10-40 deg C

Geophysical borehole logging. Final disposal of spent fuel

International Nuclear Information System (INIS)

Rouhiainen, P.

1984-01-01

Teollisuuden Voima Oy (Industrial Power Company Ltd.) will take precautions for final disposal of spent fuel in the Finnish bedrock. The first stage of the site selection studies includes drilling of a deep borehole down to approximately 1000 meters in the year 1984. The report deals with geophysical borehole logging methods, which could be used for the studies. The aim of geophysical borehole logging methods is to descripe specially hydrogeological and structural features. Only the most essential methods are dealt with in this report. Attention is paid to the information produced with the methods, derscription of the methods, interpretation and limitations. The feasibility and possibilities for the aims are evaluated. The evaluations are based mainly on the results from Sweden, England, Canada and USA as well as experiencies gained in Finland

Design of a slimline directional borehole radar antenna using FDTD

CSIR Research Space (South Africa)

Vogt, D

2008-06-01

Full Text Available , dielectric. I. INTRODUCTION Borehole radar is the application of Ground Penetrating Radar (GPR) within a borehole [11]. GPR is a technique used to delineate structures and features of a subsurface. The borehole radar technique has been used successfully..., the direction of the incoming EM wave can be determined [6]. III. FILLER MATERIAL INSIDE ANTENNA ARRAY Ideally, there is no material between the antenna body and the rock surrounding it. In that case, the filler material would be matched to the dielectric...

EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

International Nuclear Information System (INIS)

Ralhan, Ranju; Cao, Jun; Lim, Terence; MacMillan, Christina; Freeman, Jeremy L; Walfish, Paul G

2010-01-01

Proteolytic cleavage of the extracellular domain (EpEx) of Epithelial cell adhesion molecule (EpCAM) and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased proliferation of cancer cells. The clinical significance of Ep-ICD in human tumors remains an enigma. EpEx, Ep-ICD and β-catenin immunohistochemistry using specific antibodies was conducted on 58 archived thyroid cancer (TC) tissue blocks from 34 patients and correlated with survival analysis of these patients for up to 17 years. The anaplastic (ATC) and aggressive thyroid cancers showed loss of EpEx and increased nuclear and cytoplasmic accumulation of Ep-ICD. In contrast, the low grade papillary thyroid cancers (PTC) showed membranous EpEx and no detectable nuclear Ep-ICD. The ATC also showed concomitant nuclear expression of Ep-ICD and β-catenin. Kaplan-Meier Survival analysis revealed reduced overall survival (OS) for TC patients showing nuclear Ep-ICD expression or loss of membranous EpEx (p < 0.0004), median OS = 5 months as compared to 198 months for patients who did not show nuclear Ep-ICD or demonstrated only membranous EpE. We report reciprocal loss of membrane EpEx but increased nuclear and cytoplasmic accumulation of Ep-ICD in aggressive TC; nuclear Ep-ICD correlated with poor OS of TC patients. Thus nuclear Ep-ICD localization may serve as a useful biomarker for aggressive TC and may represent a novel diagnostic, prognostic and therapeutic target for aggressive TC

Thermal analyses for a nuclear-waste repository in tuff using USW-G1 borehole data

International Nuclear Information System (INIS)

Johnson, R.L.

1982-10-01

Thermal calculations using properties of tuffs obtained from the USW-G1 borehole, located near the SW margin of the Nevada Test Site (NTS), have been completed for a nuclear waste repository sited in welded tuff below the water table. The analyses considered two wasteforms, high level waste and spent fuel, emplaced at two different, gross thermal loadings, 50 and 75 kW/Acre (20.24 and 30.36 kW/ha). Calculations were made assuming that no boiling of the groundwater occurs; i.e., that the hydrostatic head potential was reestablished soon after waste emplacement. 23 figures, 2 tables

Site investigation SFR. Boremap mapping of percussion drilled borehole HFR106

Energy Technology Data Exchange (ETDEWEB)

Winell, Sofia (Geosigma AB (Sweden))

2010-06-15

This report presents the result from the Boremap mapping of the percussion drilled borehole HFR106, which is drilled from an islet located ca 220 m southeast of the pier above SFR. The purpose of the location and orientation of the borehole is to investigate the possible occurrence of gently dipping, water-bearing structures in the area. HFR106 has a length of 190.4 m and oriented 269.4 deg/-60.9 deg. The mapping is based on the borehole image (BIPS), investigation of drill cuttings and generalized, as well as more detailed geophysical logs. The dominating rock type, which occupies 68% of HFR106, is fine- to medium-grained, pinkish grey metagranite-granodiorite (rock code 101057) mapped as foliated with a medium to strong intensity. Pegmatite to pegmatitic granite (rock code 101061) occupies 29% of the borehole. Subordinate rock types are felsic to intermediate meta volcanic rock (rock code 103076) and fine- to medium-grained granite (rock code 111058). Rock occurrences (rock types < 1 m in length) occupy about 16% of the mapped interval, of which half is veins, dykes and unspecified occurrences of pegmatite and pegmatitic granite. Only 5.5% of HFR106 is inferred to be altered, mainly oxidation in two intervals with an increased fracture frequency. A total number of 845 fractures are registered in HFR106. Of these are 64 interpreted as open with a certain aperture, 230 open with a possible aperture, and 551 sealed. This result in the following fracture frequencies: 1.6 open fractures/m and 3.0 sealed fractures/m. Three fracture sets of open and sealed fractures with the orientations 290 deg/70 deg, 150 deg/85 deg and 200 deg/85 deg can be distinguished in HFR106. The fracture frequency is generally higher in the second half of the borehole, and particularly in the interval 176-187.4 m.

Site investigation SFR. Boremap mapping of percussion drilled borehole HFR106

International Nuclear Information System (INIS)

Winell, Sofia

2010-06-01

This report presents the result from the Boremap mapping of the percussion drilled borehole HFR106, which is drilled from an islet located ca 220 m southeast of the pier above SFR. The purpose of the location and orientation of the borehole is to investigate the possible occurrence of gently dipping, water-bearing structures in the area. HFR106 has a length of 190.4 m and oriented 269.4 deg/-60.9 deg. The mapping is based on the borehole image (BIPS), investigation of drill cuttings and generalized, as well as more detailed geophysical logs. The dominating rock type, which occupies 68% of HFR106, is fine- to medium-grained, pinkish grey metagranite-granodiorite (rock code 101057) mapped as foliated with a medium to strong intensity. Pegmatite to pegmatitic granite (rock code 101061) occupies 29% of the borehole. Subordinate rock types are felsic to intermediate meta volcanic rock (rock code 103076) and fine- to medium-grained granite (rock code 111058). Rock occurrences (rock types < 1 m in length) occupy about 16% of the mapped interval, of which half is veins, dykes and unspecified occurrences of pegmatite and pegmatitic granite. Only 5.5% of HFR106 is inferred to be altered, mainly oxidation in two intervals with an increased fracture frequency. A total number of 845 fractures are registered in HFR106. Of these are 64 interpreted as open with a certain aperture, 230 open with a possible aperture, and 551 sealed. This result in the following fracture frequencies: 1.6 open fractures/m and 3.0 sealed fractures/m. Three fracture sets of open and sealed fractures with the orientations 290 deg/70 deg, 150 deg/85 deg and 200 deg/85 deg can be distinguished in HFR106. The fracture frequency is generally higher in the second half of the borehole, and particularly in the interval 176-187.4 m

A strategy to seal exploratory boreholes in unsaturated tuff; Yucca Mountain Site Characterization Project

Energy Technology Data Exchange (ETDEWEB)

Fernandez, J.A. [Sandia National Labs., Albuquerque, NM (United States); Case, J.B.; Givens, C.A.; Carney, B.C. [IT Corp., Albuquerque, NM (United States)

1994-04-01

This report presents a strategy for sealing exploratory boreholes associated with the Yucca Mountain Site Characterization Project. Over 500 existing and proposed boreholes have been considered in the development of this strategy, ranging from shallow (penetrating into alluvium only) to deep (penetrating into the groundwater table). Among the comprehensive list of recommendations are the following: Those boreholes within the potential repository boundary and penetrating through the potential repository horizon are the most significant boreholes from a performance standpoint and should be sealed. Shallow boreholes are comparatively insignificant and require only nominal sealing. The primary areas in which to place seals are away from high-temperature zones at a distance from the potential repository horizon in the Paintbrush nonwelded tuff and the upper portion of the Topopah Spring Member and in the tuffaceous beds of the Calico Hills Unit. Seals should be placed prior to waste emplacement. Performance goals for borehole seals both above and below the potential repository are proposed. Detailed construction information on the boreholes that could be used for future design specifications is provided along with a description of the environmental setting, i.e., the geology, hydrology, and the in situ and thermal stress states. A borehole classification scheme based on the condition of the borehole wall in different tuffaceous units is also proposed. In addition, calculations are presented to assess the significance of the boreholes acting as preferential pathways for the release of radionuclides. Design calculations are presented to answer the concerns of when, where, and how to seal. As part of the strategy development, available technologies to seal exploratory boreholes (including casing removal, borehole wall reconditioning, and seal emplacement) are reviewed.

FE-study for lithostatic pressure measurement in the 600 m borehole experiment

International Nuclear Information System (INIS)

Hamilton, L.F.M.; Benneker, P.B.J.M.

1990-05-01

In the Asse-2 salt mine an experiment is set up by ECN in the 600 m borehole to perform in-situ convergence measurements which can be used to validate or to determine the constitutive relations between stresses and deformations of the rocksalt. An experiment is planned in which the convergence of the borehole can be measured with different pressures created in the borehole. For this experiment a device has been developed at ECN which also will be used to measure the in-situ elasticity of the salt. This measuring device is designed in such a way that a pressure can be realized in the borehole and the deformation of the hole can be measured at the same time. In this report analyses are presented that are used to adjust the design of the pressure unit to the specific needs induced by the fact that the depth of the borehole is only 300 m due to drilling problems instead of the intended 600 m. Since the lithostatic pressure at this depth is smaller the convergence rate of the borehole is reduced. From the results presented in this report it can be concluded that it is not necessary to change the basic concept of the measurement as it was planned in the 600 m deep borehole. After the device has been placed into the borehole at a distance of 3 m from the bottom the empty space must be filled up with salt concrete up to 3 m above the pressure unit. In this way the interaction with the borehole bottom and the transition between the open and the filled borehole can be neglected. Some changes in the design are necessary to be able to measure the deformations of the borehole with enough accuracy. Based on these changes a measuring program has been defined in such a way that the experimental period is optimally used and the expected evolution of the volume change and pressure can be measured with enough accuracy. For three different constitutive models a prediction is made for the evolution of the pressure and the volume change resulting from the defined measuring program

Impact of postglacial warming on borehole reconstructions of last millennium temperatures

Directory of Open Access Journals (Sweden)

V. Rath

2012-06-01

Full Text Available The investigation of observed borehole temperatures has proved to be a valuable tool for the reconstruction of ground surface temperature histories. However, there are still many open questions concerning the significance and accuracy of the reconstructions from these data. In particular, the temperature signal of the warming after the Last Glacial Maximum is still present in borehole temperature profiles. It is shown here that this signal also influences the relatively shallow boreholes used in current paleoclimate inversions to estimate temperature changes in the last centuries by producing errors in the determination of the steady state geothermal gradient. However, the impact on estimates of past temperature changes is weaker. For deeper boreholes, the curvature of the long-term signal is significant. A correction based on simple assumptions about glacial–interglacial temperature changes shows promising results, improving the extraction of millennial scale signals. The same procedure may help when comparing observed borehole temperature profiles with the results from numerical climate models.

Highlights from e-EPS: the 2015 EPS High Energy Physics Prize winners

CERN Multimedia

Thomas Lohse, e-EPS News

2015-01-01

The EPS High Energy Physics Division announces the winners of its 2015 prizes, which will be awarded at the Europhysics Conference on High-Energy Physics (EPS-HEP 2015), Vienna (Austria) 22−29 July. Many people from CERN were among the winners.   The 2015 High Energy and Particle Physics Prize, for an outstanding contribution to High Energy Physics, is awarded to James D. Bjorken “for his prediction of scaling behaviour in the structure of the proton that led to a new understanding of the b interaction”, and to Guido Altarelli, Yuri L. Dokshitzer, Lev Lipatov, and Giorgio Parisi “for developing a probabilistic field theory framework for the dynamics of quarks and gluons, enabling a quantitative understanding of high-energy collisions involving hadrons”. The 2015 Giuseppe and Vanna Cocconi Prize, for an outstanding contribution to Particle Astrophysics and Cosmology in the past 15 years, is awarded to Francis Halzen “for his visiona...

Geophysical borehole logging in the unsaturated zone, Yucca Mountain, Nevada

International Nuclear Information System (INIS)

Schimschal, U.; Nelson, P.H.

1991-01-01

Borehole geophysical logging for site characterization in the volcanic rocks at the proposed nuclear waste repository at Yucca Mountain, Nevada, requires data collection under rather unusual conditions. Logging tools must operate in rugose, dry holes above the water table in the unsaturated zone. Not all logging tools will operate in this environment, therefore; careful consideration must be given to selection and calibration. A sample suite of logs is presented that demonstrates correlation of geological formations from borehole to borehole, the definition of zones of altered mineralogy, and the quantitative estimates of rock properties. The authors show the results of an exploratory calculation of porosity and water saturation based upon density and epithermal neutron logs. Comparison of the results with a few core samples is encouraging, particularly because the logs can provide continuous data in boreholes where core samples are not available

EpCAM nuclear localization identifies aggressive Thyroid Cancer and is a marker for poor prognosis

Directory of Open Access Journals (Sweden)

MacMillan Christina

2010-06-01

Full Text Available Abstract Background Proteolytic cleavage of the extracellular domain (EpEx of Epithelial cell adhesion molecule (EpCAM and nuclear signaling by its intracellular oncogenic domain Ep-ICD has recently been implicated in increased proliferation of cancer cells. The clinical significance of Ep-ICD in human tumors remains an enigma. Methods EpEx, Ep-ICD and β-catenin immunohistochemistry using specific antibodies was conducted on 58 archived thyroid cancer (TC tissue blocks from 34 patients and correlated with survival analysis of these patients for up to 17 years. Results The anaplastic (ATC and aggressive thyroid cancers showed loss of EpEx and increased nuclear and cytoplasmic accumulation of Ep-ICD. In contrast, the low grade papillary thyroid cancers (PTC showed membranous EpEx and no detectable nuclear Ep-ICD. The ATC also showed concomitant nuclear expression of Ep-ICD and β-catenin. Kaplan-Meier Survival analysis revealed reduced overall survival (OS for TC patients showing nuclear Ep-ICD expression or loss of membranous EpEx (p Conclusion We report reciprocal loss of membrane EpEx but increased nuclear and cytoplasmic accumulation of Ep-ICD in aggressive TC; nuclear Ep-ICD correlated with poor OS of TC patients. Thus nuclear Ep-ICD localization may serve as a useful biomarker for aggressive TC and may represent a novel diagnostic, prognostic and therapeutic target for aggressive TC.

Method for simultaneous measurement of borehole and formation neutron decay-times

International Nuclear Information System (INIS)

Smith, H.D.; Arnold, D.M.

1982-01-01

A method is described of making in situ measurements of the thermal neutron decay time of earth formations in the vicinity of a wellbore. The borehole and earth formations are irradiated, with pulsed fast neutrons and, during the interval between neutron pulses, capture gamma radiation is measured in at least four, non-overlapping, contiguous time intervals. Count-rates representative of thermal neutron populations in the borehole and the formations are made during each of the time intervals. A background radiation measurement for correcting the count-rates is preferably also periodically made. The count-rates are combined to derive simultaneously the formation and borehole neutron lifetime components which are recorded as a function of borehole depth. (author)

A Hydraulic Stress Measurement System for Deep Borehole Investigations

Science.gov (United States)

Ask, Maria; Ask, Daniel; Cornet, Francois; Nilsson, Tommy

2017-04-01

Luleå University of Technology (LTU) is developing and building a wire-line system for hydraulic rock stress measurements, with funding from the Swedish Research Council and Luleå University of Technology. In this project, LTU is collaborating with University of Strasbourg and Geosigma AB. The stress state influences drilling and drillability, as well as rock mass stability and permeability. Therefore, knowledge about the state of in-situ stress (stress magnitudes, and orientations) and its spatial variation with depth is essential for many underground rock engineering projects, for example for underground storage of hazardous material (e.g. nuclear waste, carbon dioxide), deep geothermal exploration, and underground infrastructure (e.g. tunneling, hydropower dams). The system is designed to conduct hydraulic stress testing in slim boreholes. There are three types of test methods: (1) hydraulic fracturing, (2) sleeve fracturing and (3) hydraulic testing of pre-existing fractures. These are robust methods for determining in situ stresses from boreholes. Integration of the three methods allows determination of the three-dimensional stress tensor and its spatial variation with depth in a scientific unambiguously way. The stress system is composed of a downhole and a surface unit. The downhole unit consists of hydraulic fracturing equipment (straddle packers and downhole imaging tool) and their associated data acquisition systems. The testing system is state of the art in several aspects including: (1) Large depth range (3 km), (2) Ability to test three borehole dimensions (N=76 mm, H=96 mm, and P=122 mm), (3) Resistivity imager maps the orientation of tested fracture; (4) Highly stiff and resistive to corrosion downhole testing equipment; and (5) Very detailed control on the injection flow rate and cumulative volume is obtained by a hydraulic injection pump with variable piston rate, and a highly sensitive flow-meter. At EGU General Assembly 2017, we would like to

Comparative study of geological, hydrological, and geophysical borehole investigations

International Nuclear Information System (INIS)

Magnusson, K.A.; Duran, O.

1984-09-01

The understanding of the permeability of the bedrock can be improved by supplementing the results of the water injection tests with information from core mapping, TB-inspection and borehole geophysics. The comparison between different borehole investigations encompasses core mapping, TV-inspection and various geophysical bore hole measurements. The study includes data from two different study areas, namely Kraakemaala and Finnsjoen. In these two areas, extensive geological, hydrological and geophysical investigation have been carried out. The fractures and microfractures in crystalline rock constitute the main transport paths for both groundwater and electric currents. They will therefore govern both the permeability and the resistivity of the rock. In order to get a better understanding of the influence of fractures on permeability and resistivity, a detailed comparison has been made between the hydraulic conductivity, respectively, and the character of fractures in the core and the borehole wall. The fractures show very large variations in hydraulic conductivity. Microfractures and most of the thin fractures have no measurable hydraulic conductivity (in this case -9 m s -1 ), while test sections which contain a single isloated fracture can have no measurable, to rather high hydraulic conductivities (> 10 -7 m s -1 ). Wide fracture zones often have hydraulic conductivities which vary from very low (less than 2 x 10 -9 m s -1 ) to high values (10 -5 m s -1 ). This indicates that the hydraulic conductivity is governed by a few discrete fractures. The resistivity shows a continous variation in the range 1,000- 100,000 ohm-m and a relatively poor correlation with hydraulic conductivities. The observed difference is considered to the effect of restriction of water flow on a few channels, while electric surface condition, i.e. current transport through thin water films, makes current transport possible through fractures with very small aperatures. (Author)

Core drilling of deep borehole OL-KR3B at Olkiluoto in Eurajoki 2005

Energy Technology Data Exchange (ETDEWEB)

Rautio, T. [Suomen Malmi Oy, Espoo (Finland)

2005-10-15

Posiva Oy submitted an application for the Decision in Principle to the Finnish Government in May 1999. A positive decision was made at the end of 2000 by the Government. The Finnish Parliament ratified the Decision in Principle on the final disposal facility for spent nuclear fuel at Olkiluoto, Eurajoki in May 2001. The decision makes it possible for Posiva to focus the confirming bedrock investigations at Olkiluoto, where in the next few years an underground rock characterisation facility, ONKALO, will be constructed. As a part of the investigations Suomen Malmi Oy (Smoy) core drilled 530.60 m deep borehole with a diameter of 75.7 mm at Olkiluoto in summer 2005. This borehole was aimed to get additional information of the quality of bedrock in the area, where a new shaft with a diameter of 3 m is planned to be located. The identification number of the borehole is OL-KR38. A set of monitoring measurements and samplings from the drilling and returning water was carried out during the drilling. Both the volume and the electric conductivity of the drilling water and the returning water were recorded. The drill rig was computer controlled and during drilling the computer recorded information about drilling parameters. The objective of these measurements was to obtain more information about bedrock and groundwater properties. Sodium fluorescein was used as a label agent in the drilling water. The volume of the used drilling water was about 473m{sup 3} and the measured volume of the returning water was about 38m{sup 3} in borehole OL-KR38. The deviation of the borehole was measured with the deviation measuring instruments EMS and Devitool Peewee. The results of the EMS measurements indicate that borehole OL-KR38 deviates 1.02 m south and 0.58 m west from the target point at the borehole depth of 525 m. Uniaxial compressive strength, Young's Modulus and Poisson's ratio were measured from the core samples. The average uniaxial compressive strength is about 106

Numerical Simulation of Hydraulic Fracture Propagation Guided by Single Radial Boreholes

Directory of Open Access Journals (Sweden)

Tiankui Guo

2017-10-01

Full Text Available Conventional hydraulic fracturing is not effective in target oil development zones with available wellbores located in the azimuth of the non-maximum horizontal in-situ stress. To some extent, we think that the radial hydraulic jet drilling has the function of guiding hydraulic fracture propagation direction and promoting deep penetration, but this notion currently lacks an effective theoretical support for fracture propagation. In order to verify the technology, a 3D extended finite element numerical model of hydraulic fracturing promoted by the single radial borehole was established, and the influences of nine factors on propagation of hydraulic fracture guided by the single radial borehole were comprehensively analyzed. Moreover, the term ‘Guidance factor (Gf’ was introduced for the first time to effectively quantify the radial borehole guidance. The guidance of nine factors was evaluated through gray correlation analysis. The experimental results were consistent with the numerical simulation results to a certain extent. The study provides theoretical evidence for the artificial control technology of directional propagation of hydraulic fracture promoted by the single radial borehole, and it predicts the guidance effect of a single radial borehole on hydraulic fracture to a certain extent, which is helpful for planning well-completion and fracturing operation parameters in radial borehole-promoted hydraulic fracturing technology.

Production of Z0 bosons in elastic and quasi-elastic ep collisions at HERA

International Nuclear Information System (INIS)

Abramowicz, H.; Abt, I.; Adamczyk, L.

2012-10-01

The production of Z 0 bosons in the reaction ep → eZ 0 p (*) , where p (*) stands for a proton or a low-mass nucleon resonance, has been studied in ep collisions at HERA using the ZEUS detector. The analysis is based on a data sample collected between 1996 and 2007, amounting to 496 pb -1 of integrated luminosity. The Z 0 was measured in the hadronic decay mode. The elasticity of the events was ensured by a cut on η max max is the maximum pseudorapidity of energy deposits in the calorimeter defined with respect to the proton beam direction. A signal was observed at the Z 0 mass. The cross section of the reaction ep → eZ 0 p (*) was measured to be σ (ep → eZ 0 p (*) ) = 0.13 ± 0.06 (stat.) ± 0.01 (syst.) pb, in agreement with the Standard Model prediction of 0.16 pb. This is the first measurement of Z 0 production in ep collisions.

HIV-1 Env DNA vaccine plus protein boost delivered by EP expands B- and T-cell responses and neutralizing phenotype in vivo.

Directory of Open Access Journals (Sweden)

Kar Muthumani

Full Text Available An effective HIV vaccine will most likely require the induction of strong T-cell responses, broadly neutralizing antibodies (bNAbs, and the elicitation of antibody-dependent cellular cytotoxicity (ADCC. Previously, we demonstrated the induction of strong HIV/SIV cellular immune responses in macaques and humans using synthetic consensus DNA immunogens delivered via adaptive electroporation (EP. However, the ability of this improved DNA approach to prime for relevant antibody responses has not been previously studied. Here, we investigate the immunogenicity of consensus DNA constructs encoding gp140 sequences from HIV-1 subtypes A, B, C and D in a DNA prime-protein boost vaccine regimen. Mice and guinea pigs were primed with single- and multi-clade DNA via EP and boosted with recombinant gp120 protein. Sera were analyzed for gp120 binding and induction of neutralizing antibody activity. Immunization with recombinant Env protein alone induced low-titer binding antibodies with limited neutralization breath. In contrast, the synthetic DNA prime-protein boost protocol induced significantly higher antibody binding titers. Furthermore, sera from DNA prime-protein boost groups were able to neutralize a broader range of viruses in a panel of tier 1 clade B viruses as well as multiple tier 1 clade A and clade C viruses. Further investigation of synthetic DNA prime plus adaptive EP plus protein boost appears warranted.

Preferences for Long-Acting Pre-exposure Prophylaxis (PrEP), Daily Oral PrEP, or Condoms for HIV Prevention Among U.S. Men Who Have Sex with Men.

Science.gov (United States)

Greene, George J; Swann, Greg; Fought, Angela J; Carballo-Diéguez, Alex; Hope, Thomas J; Kiser, Patrick F; Mustanski, Brian; D'Aquila, Richard T

2017-05-01

HIV prevention method preferences were evaluated among 512 U.S. men who have sex with men (MSM; median age: 22 years). Approximately 90 % consistently preferred one option across pairwise comparisons of condoms, daily oral pre-exposure prophylaxis (PrEP), and long-acting PrEP delivered via either an injectable or one of two types of PrEP implants differing in visibility. Condoms were most frequently preferred (33.8 %), followed by non-visible implants (21.5 %), and oral PrEP (17.0 %); HIV risk was reported by more choosing implants. In a follow-up question comparing the four PrEP options only, daily oral pills and non-visible implants were most frequently preferred (35.5 and 34.3 %, respectively), followed by injections (25.2 %) and visible implants (4.3 %). An inductive, open-coding approach determined that convenience, duration of protection, and privacy were the most commonly cited reasons for a PrEP method choice, and associated with self-report of HIV risk. Tailoring PrEP product development to privacy and other concerns important to those at highest HIV risk may improve HIV prevention.

Interpretation and mathematical modeling of temporal changes of temperature observed in borehole Yaxcopoil-1 within the Chicxulub impact structure, Mexico

Czech Academy of Sciences Publication Activity Database

Šafanda, Jan; Wilhelm, H.; Heidinger, P.; Čermák, Vladimír

2009-01-01

Roč. 372, č. 1-4 (2009), s. 9-16 ISSN 0022-1694 R&D Projects: GA ČR(CZ) GA205/06/1181 Grant - others:Deutsche Forschungsgemeinschaft(DE) W1 687/17-1,2,3 Institutional research plan: CEZ:AV0Z30120515 Keywords : repeated borehole temperature logging * karstic environment * Yucatan * groundwater convection * heat transport numerical simulation * fluid dynamics Subject RIV: DC - Siesmology, Volcanology, Earth Structure Impact factor: 2.433, year: 2009

Geophysical borehole logging of the boreholes KR23 extension, KR29 and KR29b at Olkiluoto 2004

International Nuclear Information System (INIS)

Lahti, M.; Heikkinen, E.

2005-04-01

Suomen Malmi Oy conducted geophysical borehole logging of the boreholes KR23 extension, KR25b, KR29 and KR29b at the Olkiluoto site in Eurajoki during October 2004. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and processing of the acoustic data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Geophysical borehole logging of the boreholes KR23 extension, KR29 and KR29b at Olkiluoto 2004

Energy Technology Data Exchange (ETDEWEB)

Lahti, M. [Suomen Malmi Oy, Espoo (Finland); Heikkinen, E. [JP-Fintact Oy, Vantaa (Finland)

2005-04-15

Suomen Malmi Oy conducted geophysical borehole logging of the boreholes KR23 extension, KR25b, KR29 and KR29b at the Olkiluoto site in Eurajoki during October 2004. The survey is a part of Posiva Oy's detailed investigation program for the final disposal of spent nuclear fuel. The assignment included the field work and processing of the acoustic data. The report describes the field operation, equipment as well as processing procedures and shows the obtained results and their quality in the appendices. The raw and processed data are delivered digitally in WellCAD and Excel format. (orig.)

Additional borehole geophysical logging at Waste Area Grouping 1 at Oak Ridge National Laboratory, Oak Ridge, Tennessee

International Nuclear Information System (INIS)

1994-07-01

This technical memorandum describes the borehole geophysical logging performed at selected coreholes at Waste Area Grouping 1 between March and November 1991 in support of the remedial investigation. The primary objectives of the borehole geophysical logging program were to (1) identify fractured bedrock zones and identify those fractured bedrock zones participating in active groundwater flow, (2) correlate the fractured intervals with the regional stratigraphy described, and (3) further characterize local bedrock geology and hydrogeology and gain insight about the bedrock aquifer flow system. A secondary objective was to provide stratigraphic correlations with existing logs for coreholes CH001 through CH005. Fractured bedrock zones and active or open fractures were identified in all coreholes logged. The fracture identification and analysis process was intended to distinguish between open or active fractures participating in active groundwater flow and closed or inactive fractures that are partially or completely filled (such as with calcite mineralization) and do not support groundwater circulation. Most of the fractures identified are bedding plane. Fracture occurrence varies with the different units of the Chickamauga Group; the greatest density of fractures and active fractures occurs in the upper 150 ft of stratum cored. Fractures actively contributing to groundwater flow were also identified, and direction of fluid movement within fractures was identified for those coreholes with flowmeter data

Multi-Lepton Production at High Transverse Momenta in ep Collisions at HERA

CERN Document Server

Aaron, F.D.; Andreev, V.; Antunovic, B.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Bacchetta, A.; Backovic, S.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Beckingham, M.; Begzsuren, K.; Behnke, O.; Belousov, A.; Berger, N.; Bizot, J.C.; Boenig, M.-O.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A.J.; Cantun Avila, K.B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J.G.; Coughlan, J.A.; Cozzika, G.; Cvach, J.; Dainton, J.B.; Daum, K.; Deak, M.; de Boer, Y.; Delcourt, B.; Del Degan, M.; Delvax, J.; De Roeck, A.; De Wolf, E.A.; Diaconu, C.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eliseev, A.; Elsen, E.; Essenov, S.; Falkiewicz, A.; Faulkner, P.J.W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, Samvel; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Grell, B.R.; Grindhammer, G.; Habib, S.; Haidt, D.; Hansson, M.; Helebrant, C.; Henderson, R.C.W.; Hennekemper, E.; Henschel, H.; Herrera, G.; Hildebrandt, M.; Hiller, K.H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Jacquet, M.; Janssen, M.E.; Janssen, X.; Jemanov, V.; Jonsson, L.; Johnson, D.P.; Jung, Andreas Werner; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I.R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knutsson, A.; Kogler, R.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Kruger, K.; Kutak, K.; Landon, M.P.J.; Lange, W.; Lastovicka-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Li, G.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martyn, H.-U.; Maxfield, S.J.; Mehta, A.; Meier, K.; Meyer, A.B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Moreau, F.; Morozov, A.; Morris, J.V.; Mozer, Matthias Ulrich; Mudrinic, M.; Muller, K.; Murin, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, Paul R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Olivier, B.; Olsson, J.E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G.D.; Pejchal, O.; Peng, H.; Perez, E.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Placakyte, R.; Polifka, R.; Povh, B.; Preda, T.; Radescu, V.; Rahmat, A.J.; Raicevic, N.; Raspiareza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Ruiz Tabasco, J.E.; Rurikova, Z.; Rusakov, S.; Salek, D.; Salvaire, F.; Sankey, D.P.C.; Sauter, M.; Sauvan, E.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schoning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R.N.; Sheviakov, I.; Shtarkov, L.N.; Shushkevich, S.; Sloan, T.; Smiljanic, Ivan; Smirnov, P.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, Arnd E.; Staykova, Z.; Steder, M.; Stella, B.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P.D.; Toll, T.; Tomasz, F.; Tran, T.H.; Traynor, D.; Trinh, T.N.; Truol, P.; Tsakov, I.; Tseepeldorj, B.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, K.; Valkarova, A.; Vallee, C.; Van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; Wegener, D.; Wessels, M.; Wissing, Ch.; Wunsch, E.; Yeganov, V.; Zacek, J.; Zalesak, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y.C.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2008-01-01

Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full ep data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb-1. Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of e+e- and mu+mu- pairs are derived in a restricted phase space dominated by photon-photon collisions. In general, good agreement is found with Standard Model predictions. Events are observed with a total scalar sum of lepton transverse momenta above 100 GeV where the Standard Model expectation is low. In this region, combining di-lepton and tri-lepton classes, five events are observed in e+p collisions, compared to a Standard Model expectation of 0.96+-0.12, while no such event is observed in e-p data for 0.64+-0.09 expected.

Multi-lepton production at high transverse momenta in ep collisions at HERA

Science.gov (United States)

H1 Collaboration; Aaron, F. D.; Alexa, C.; Andreev, V.; Antunovic, B.; Aplin, S.; Asmone, A.; Astvatsatourov, A.; Bacchetta, A.; Backovic, S.; Baghdasaryan, A.; Baranov, P.; Barrelet, E.; Bartel, W.; Beckingham, M.; Begzsuren, K.; Behnke, O.; Belousov, A.; Berger, N.; Bizot, J. C.; Boenig, M.-O.; Boudry, V.; Bozovic-Jelisavcic, I.; Bracinik, J.; Brandt, G.; Brinkmann, M.; Brisson, V.; Bruncko, D.; Bunyatyan, A.; Buschhorn, G.; Bystritskaya, L.; Campbell, A. J.; Cantun Avila, K. B.; Cassol-Brunner, F.; Cerny, K.; Cerny, V.; Chekelian, V.; Cholewa, A.; Contreras, J. G.; Coughlan, J. A.; Cozzika, G.; Cvach, J.; Dainton, J. B.; Daum, K.; Deák, M.; de Boer, Y.; Delcourt, B.; Del Degan, M.; Delvax, J.; de Roeck, A.; de Wolf, E. A.; Diaconu, C.; Dodonov, V.; Dossanov, A.; Dubak, A.; Eckerlin, G.; Efremenko, V.; Egli, S.; Eliseev, A.; Elsen, E.; Essenov, S.; Falkiewicz, A.; Faulkner, P. J. W.; Favart, L.; Fedotov, A.; Felst, R.; Feltesse, J.; Ferencei, J.; Fleischer, M.; Fomenko, A.; Gabathuler, E.; Gayler, J.; Ghazaryan, S.; Glazov, A.; Glushkov, I.; Goerlich, L.; Goettlich, M.; Gogitidze, N.; Gouzevitch, M.; Grab, C.; Greenshaw, T.; Grell, B. R.; Grindhammer, G.; Habib, S.; Haidt, D.; Hansson, M.; Helebrant, C.; Henderson, R. C. W.; Hennekemper, E.; Henschel, H.; Herrera, G.; Hildebrandt, M.; Hiller, K. H.; Hoffmann, D.; Horisberger, R.; Hovhannisyan, A.; Hreus, T.; Jacquet, M.; Janssen, M. E.; Janssen, X.; Jemanov, V.; Jönsson, L.; Johnson, D. P.; Jung, A. W.; Jung, H.; Kapichine, M.; Katzy, J.; Kenyon, I. R.; Kiesling, C.; Klein, M.; Kleinwort, C.; Klimkovich, T.; Kluge, T.; Knutsson, A.; Kogler, R.; Korbel, V.; Kostka, P.; Kraemer, M.; Krastev, K.; Kretzschmar, J.; Kropivnitskaya, A.; Krüger, K.; Kutak, K.; Landon, M. P. J.; Lange, W.; Laštovička-Medin, G.; Laycock, P.; Lebedev, A.; Leibenguth, G.; Lendermann, V.; Levonian, S.; Li, G.; Lipka, K.; Liptaj, A.; List, B.; List, J.; Loktionova, N.; Lopez-Fernandez, R.; Lubimov, V.; Lucaci-Timoce, A.-I.; Lytkin, L.; Makankine, A.; Malinovski, E.; Marage, P.; Marti, Ll.; Martyn, H.-U.; Maxfield, S. J.; Mehta, A.; Meier, K.; Meyer, A. B.; Meyer, H.; Meyer, H.; Meyer, J.; Michels, V.; Mikocki, S.; Milcewicz-Mika, I.; Moreau, F.; Morozov, A.; Morris, J. V.; Mozer, M. U.; Mudrinic, M.; Müller, K.; Murín, P.; Nankov, K.; Naroska, B.; Naumann, Th.; Newman, P. R.; Niebuhr, C.; Nikiforov, A.; Nowak, G.; Nowak, K.; Nozicka, M.; Olivier, B.; Olsson, J. E.; Osman, S.; Ozerov, D.; Palichik, V.; Panagoulias, I.; Pandurovic, M.; Papadopoulou, Th.; Pascaud, C.; Patel, G. D.; Pejchal, O.; Peng, H.; Perez, E.; Petrukhin, A.; Picuric, I.; Piec, S.; Pitzl, D.; Plačakytė, R.; Polifka, R.; Povh, B.; Preda, T.; Radescu, V.; Rahmat, A. J.; Raicevic, N.; Raspiareza, A.; Ravdandorj, T.; Reimer, P.; Rizvi, E.; Robmann, P.; Roland, B.; Roosen, R.; Rostovtsev, A.; Rotaru, M.; Ruiz Tabasco, J. E.; Rurikova, Z.; Rusakov, S.; Salek, D.; Salvaire, F.; Sankey, D. P. C.; Sauter, M.; Sauvan, E.; Schmidt, S.; Schmitt, S.; Schmitz, C.; Schoeffel, L.; Schöning, A.; Schultz-Coulon, H.-C.; Sefkow, F.; Shaw-West, R. N.; Sheviakov, I.; Shtarkov, L. N.; Shushkevich, S.; Sloan, T.; Smiljanic, I.; Smirnov, P.; Soloviev, Y.; Sopicki, P.; South, D.; Spaskov, V.; Specka, A.; Staykova, Z.; Steder, M.; Stella, B.; Straumann, U.; Sunar, D.; Sykora, T.; Tchoulakov, V.; Thompson, G.; Thompson, P. D.; Toll, T.; Tomasz, F.; Tran, T. H.; Traynor, D.; Trinh, T. N.; Truöl, P.; Tsakov, I.; Tseepeldorj, B.; Tsurin, I.; Turnau, J.; Tzamariudaki, E.; Urban, K.; Valkárová, A.; Vallée, C.; van Mechelen, P.; Vargas Trevino, A.; Vazdik, Y.; Vinokurova, S.; Volchinski, V.; Wegener, D.; Wessels, M.; Wissing, Ch.; Wünsch, E.; Yeganov, V.; Žáček, J.; Zálešák, J.; Zhang, Z.; Zhelezov, A.; Zhokin, A.; Zhu, Y. C.; Zimmermann, T.; Zohrabyan, H.; Zomer, F.

2008-10-01

Processes leading to a final state with at least two high transverse momentum leptons (electrons or muons) are studied using the full ep data sample collected by the H1 experiment at HERA. The data correspond to an integrated luminosity of 463 pb-1. Di-lepton and tri-lepton event classes are investigated. Cross sections of the production of ee and μμ pairs are derived in a restricted phase space dominated by photon photon collisions. In general, good agreement is found with Standard Model predictions. Events are observed with a total scalar sum of lepton transverse momenta above 100 GeV where the Standard Model expectation is low. In this region, combining di-lepton and tri-lepton classes, five events are observed in ep collisions, compared to a Standard Model expectation of 0.96±0.12, while no such event is observed in ep data for 0.64±0.09 expected.

Biosorption of Cadmium by Non-Toxic Extracellular Polymeric Substances (EPS Synthesized by Bacteria from Marine Intertidal Biofilms

Directory of Open Access Journals (Sweden)

Juan Carlos Camacho-Chab

2018-02-01

Full Text Available Cadmium is a major heavy metal found in polluted aquatic environments, mainly derived from industrial production processes. We evaluated the biosorption of solubilized Cd2+ using the extracellular polymeric substances (EPS produced by Bacillus sp. MC3B-22 and Microbacterium sp. MC3B-10 (Microbactan; these bacteria were originally isolated from intertidal biofilms off the coast of Campeche, Mexico. EPS were incubated with different concentrations of cadmium in ultrapure water. Residual Cd2+ concentrations were determined by Inductive Coupled Plasma-Optic Emission Spectrometry and the maximum sorption capacity (Qmax was calculated according to the Langmuir model. EPS were characterized by X-ray photoelectron spectroscopy (XPS before and after sorption. The Qmax of Cd2+ was 97 mg g−1 for Microbactan and 141 mg g−1 for MC3B-22 EPS, these adsorption levels being significantly higher than previously reported for other microbial EPS. In addition, XPS analysis revealed changes in structure of EPS after biosorption and showed that amino functional groups contributed to the binding of Cd2+, unlike other studies that show the carbohydrate fraction is responsible for this activity. This work expands the current view of bacterial species capable of synthesizing EPS with biosorbent potential for cadmium and provides evidence that different chemical moieties, other than carbohydrates, participate in this process.

Deep Borehole Disposal as an Alternative Concept to Deep Geological Disposal

Energy Technology Data Exchange (ETDEWEB)

Lee, Jongyoul; Lee, Minsoo; Choi, Heuijoo; Kim, Kyungsu [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

2016-10-15

In this paper, the general concept and key technologies for deep borehole disposal of spent fuels or HLW, as an alternative method to the mined geological disposal method, were reviewed. After then an analysis on the distance between boreholes for the disposal of HLW was carried out. Based on the results, a disposal area were calculated approximately and compared with that of mined geological disposal. These results will be used as an input for the analyses of applicability for DBD in Korea. The disposal safety of this system has been demonstrated with underground research laboratory and some advanced countries such as Finland and Sweden are implementing their disposal project on commercial stage. However, if the spent fuels or the high-level radioactive wastes can be disposed of in the depth of 3-5 km and more stable rock formation, it has several advantages. Therefore, as an alternative disposal concept to the mined deep geological disposal concept (DGD), very deep borehole disposal (DBD) technology is under consideration in number of countries in terms of its outstanding safety and cost effectiveness. In this paper, the general concept of deep borehole disposal for spent fuels or high level radioactive wastes was reviewed. And the key technologies, such as drilling technology of large diameter borehole, packaging and emplacement technology, sealing technology and performance/safety analyses technologies, and their challenges in development of deep borehole disposal system were analyzed. Also, very preliminary deep borehole disposal concept including disposal canister concept was developed according to the nuclear environment in Korea.

Deep Borehole Disposal as an Alternative Concept to Deep Geological Disposal

International Nuclear Information System (INIS)

Lee, Jongyoul; Lee, Minsoo; Choi, Heuijoo; Kim, Kyungsu

2016-01-01

In this paper, the general concept and key technologies for deep borehole disposal of spent fuels or HLW, as an alternative method to the mined geological disposal method, were reviewed. After then an analysis on the distance between boreholes for the disposal of HLW was carried out. Based on the results, a disposal area were calculated approximately and compared with that of mined geological disposal. These results will be used as an input for the analyses of applicability for DBD in Korea. The disposal safety of this system has been demonstrated with underground research laboratory and some advanced countries such as Finland and Sweden are implementing their disposal project on commercial stage. However, if the spent fuels or the high-level radioactive wastes can be disposed of in the depth of 3-5 km and more stable rock formation, it has several advantages. Therefore, as an alternative disposal concept to the mined deep geological disposal concept (DGD), very deep borehole disposal (DBD) technology is under consideration in number of countries in terms of its outstanding safety and cost effectiveness. In this paper, the general concept of deep borehole disposal for spent fuels or high level radioactive wastes was reviewed. And the key technologies, such as drilling technology of large diameter borehole, packaging and emplacement technology, sealing technology and performance/safety analyses technologies, and their challenges in development of deep borehole disposal system were analyzed. Also, very preliminary deep borehole disposal concept including disposal canister concept was developed according to the nuclear environment in Korea

Drilling a borehole for LEP

CERN Multimedia

1981-01-01

Boreholes were drilled along the earlier proposed line of the LEP tunnel under the Jura to find out the conditions likely to be encountered during the construction of the LEP tunnel (Annual Report 1981 p. 106, Fig. 10).

Moving to Google Cloud: Renovation of Global Borehole Temperature Database for Climate Research

Science.gov (United States)

Xiong, Y.; Huang, S.

2013-12-01

Borehole temperature comprises an independent archive of information on climate change which is complementary to the instrumental and other proxy climate records. With support from the international geothermal community, a global database of borehole temperatures has been constructed for the specific purpose of the study on climate change. Although this database has become an important data source in climate research, there are certain limitations partially because the framework of the existing borehole temperature database was hand-coded some twenty years ago. A database renovation work is now underway to take the advantages of the contemporary online database technologies. The major intended improvements include 1) dynamically linking a borehole site to Google Earth to allow for inspection of site specific geographical information; 2) dynamically linking an original key reference of a given borehole site to Google Scholar to allow for a complete list of related publications; and 3) enabling site selection and data download based on country, coordinate range, and contributor. There appears to be a good match between the enhancement requirements for this database and the functionalities of the newly released Google Fusion Tables application. Google Fusion Tables is a cloud-based service for data management, integration, and visualization. This experimental application can consolidate related online resources such as Google Earth, Google Scholar, and Google Drive for sharing and enriching an online database. It is user friendly, allowing users to apply filters and to further explore the internet for additional information regarding the selected data. The users also have ways to map, to chart, and to calculate on the selected data, and to download just the subset needed. The figure below is a snapshot of the database currently under Google Fusion Tables renovation. We invite contribution and feedback from the geothermal and climate research community to make the

Analysis of aquifer tests conducted in boreholes USW WT-10, UE-25 WT No. 12, and USW SD-7, 1995-96, Yucca Mountain, Nevada

International Nuclear Information System (INIS)

O'Brien, G.M.

1997-01-01

Single-borehole aquifer tests were conducted in three boreholes in the Yucca Mountain area between March 1995 and January 1996 to obtain estimates of borehole specific capacity and aquifer transmissivity. Analysis of aquifer testing in borehole USW SD-7 also resulted in an estimate of reservoir volume. Aquifer-test data were analyzed with the Cooper and Jacob straight-line method, two modified Theis nonequilibrium equation solutions, and a modified reservoir-limit solution. The highest estimates of transmissivity were in borehole USW WT-10, completed in the Topopah Spring Tuff. Mean transmissivity, based on the results of three drawdown tests, was 1,600 meters squared per day. Mean specific capacity in borehole USW WT-10 after 5 hours of pumping was 1,100 meters squared per day, and was estimated to be 740 meters squared per day after 24 hours of pumping. Aquifer testing in borehole UE-25 WT No. 12 appeared to be significantly affected by well losses. A mean transmissivity of 7 meters squared per day was obtained on the basis of analysis of three drawdown tests in borehole UE-25 WT No. 12. Mean specific capacity in borehole UE-25 WT No. 12, after 24 hours of pumping, was 7 meters squared per day. Borehole UE-25 WT No. 12 seemed to be producing water from fractures that could provide only a limited amount of water to the borehole

Occurrence of a Severe Acute Livestock Poisoning by Borehole ...

African Journals Online (AJOL)

This article reports on an outbreak of acute livestock poisoning by borehole water that occurred at Kargi in Marsabit District, Kenya in 2000. The borehole had been out of use for 3 years and after its rehabilitation, 7,000 animals died within a day after drinking the water. The most affected were shoats, cattle, camels and dogs ...

Observations of joint persistence and connectivity across boreholes

Energy Technology Data Exchange (ETDEWEB)

Thapa, B.B.; Karasaki, K.

1996-01-01

Observations of joint persistence and connectivity are made by comparison of digital borehole wall images of fractures, fluid conductivity logs and hydraulic injections test results. The fractures were found to be generally impersistent across vertical boreholes about 8 m apart. Many hydraulic connections were found in the same volume of rock. Direct connections through single fractures seem to be rare and connectivity appears to be controlled by fracture networks, even over small volumes.

Pre-Exposure Prophylaxis: A Narrative Review of Provider Behavior and Interventions to Increase PrEP Implementation in Primary Care.

Science.gov (United States)

Silapaswan, Andrew; Krakower, Douglas; Mayer, Kenneth H

2017-02-01

Since FDA approval of HIV pre-exposure prophylaxis (PrEP) for HIV prevention, attention has been focused on PrEP implementation. The CDC estimates that 1.2 million U.S. adults might benefit from PrEP, but only a minority are using PrEP, so there is a significant unmet need to increase access for those at risk for HIV. Given the large numbers of individuals who have indications for PrEP, there are not enough practicing specialists to meet the growing need for providers trained in providing PrEP. Moreover, since PrEP is a preventive intervention for otherwise healthy individuals, primary care providers (PCPs) should be primary prescribers of PrEP. There are important clinical considerations that providers should take into account when planning to prescribe PrEP, which are highlighted in the clinical case discussed. A growing body of research also suggests that some providers may be cautious about prescribing PrEP because of concerns regarding its "real-world" effectiveness, anticipated unintended consequences associated with its use, and ambiguity as to who should prescribe it. This review summarizes findings from studies that have assessed prescriber behavior regarding provision of PrEP, and offers recommendations on how to optimize PrEP implementation in primary care settings. Development and dissemination of educational interventions for PCPs and potential PrEP users are needed, including improved methods to assist clinicians in identifying appropriate PrEP candidates, and programs to promote medication adherence and access to social and behavioral health services. PCPs are well-positioned to prescribe PrEP and coordinate health-related services to improve the sexual health of their patients, but tailored educational programs are needed.

Ep-CAM expression in squamous cell carcinoma of the esophagus: a potential therapeutic target and prognostic marker

Directory of Open Access Journals (Sweden)

Peiper Matthias

2006-06-01

Full Text Available Abstract Background To evaluate the expression and test the clinical significance of the epithelial cellular adhesion molecule (Ep-CAM in esophageal squamous cell carcinoma (SCC to check the suitability of esophageal SCC patients for Ep-CAM directed targeted therapies. Methods The Ep-CAM expression was immunohistochemically investigated in 70 primary esophageal SCCs using the monoclonal antibody Ber-EP4. For the interpretation of the staining results, we used a standardized scoring system ranging from 0 to 3+. The survival analysis was calculated from 53 patients without distant metastasis, with R0 resection and at least 2 months of clinical follow-up. Results Ep-CAM neo-expression was observed in 79% of the tumors with three expression levels, 1+ (26%, 2+ (11% and 3+ (41%. Heterogeneous expression was observed at all expression levels. Interestingly, tumors with 3+ Ep-CAM expression conferred a significantly decreased median relapse-free survival period (log rank, p = 0.0001 and median overall survival (log rank, p = 0.0003. Multivariate survival analysis disclosed Ep-CAM 3+ expression as independent prognostic factor. Conclusion Our results suggest Ep-CAM as an attractive molecule for targeted therapy in esophageal SCC. Considering the discontenting results of the current adjuvant concepts for esophageal SCC patients, Ep-CAM might provide a promising target for an adjuvant immunotherapeutic intervention.

Radiological consequences of accidents during disposal of spent nuclear fuel in a deep borehole

Energy Technology Data Exchange (ETDEWEB)

Grundfelt, Bertil [Kemakta Konsult AB, Stockholm (Sweden)

2013-07-15

. The estimated maximum annual effective dose from one canister containing one PWR element that leaks due to damages created in conjunction with the accident is 5 mSv, primarily from {sup 137}Cs and {sup 107m}Ag. For one canister containing two BWR elements, the corresponding dose will be slightly less than 4 mSv. These doses are higher than the average background exposure of the Swedish population that amounts to about 3 mSv/year. Damage of multiple canisters will increase dose proportionally. The Swedish Radiation Safety Authority has issued regulations stipulating that the risk for harmful effects in conjunction with radioactive waste disposal should be less than 10{sup -6} per year. This corresponds to an annual effective dose of 1. 10{sup -5} Sv. In order for a facility for disposal in deep boreholes to meet this criterion, the probability of an accident in which one canister containing one PWR element is damaged at the time of the accident must be lower than 0.26 %, corresponding to 3{Chi} 10{sup -5} per disposal hole. In accidents involving damaging of a canister, a need to handle contaminated borehole mud may arise. Calculations in the current study indicate that such contaminated mud should be handled in tanks with extra shielding. It is concluded that necessary preparedness for accidents of the type described above is an obvious point of concern in any future planning of a facility for disposal of spent nuclear fuel in deep boreholes.

Radiological consequences of accidents during disposal of spent nuclear fuel in a deep borehole

International Nuclear Information System (INIS)

Grundfelt, Bertil

2013-07-01

estimated maximum annual effective dose from one canister containing one PWR element that leaks due to damages created in conjunction with the accident is 5 mSv, primarily from 137 Cs and 107m Ag. For one canister containing two BWR elements, the corresponding dose will be slightly less than 4 mSv. These doses are higher than the average background exposure of the Swedish population that amounts to about 3 mSv/year. Damage of multiple canisters will increase dose proportionally. The Swedish Radiation Safety Authority has issued regulations stipulating that the risk for harmful effects in conjunction with radioactive waste disposal should be less than 10 -6 per year. This corresponds to an annual effective dose of 1. 10 -5 Sv. In order for a facility for disposal in deep boreholes to meet this criterion, the probability of an accident in which one canister containing one PWR element is damaged at the time of the accident must be lower than 0.26 %, corresponding to 3Χ 10 -5 per disposal hole. In accidents involving damaging of a canister, a need to handle contaminated borehole mud may arise. Calculations in the current study indicate that such contaminated mud should be handled in tanks with extra shielding. It is concluded that necessary preparedness for accidents of the type described above is an obvious point of concern in any future planning of a facility for disposal of spent nuclear fuel in deep boreholes

QCD studies in ep collisions

International Nuclear Information System (INIS)

Smith, W.H.

1997-01-01

These lectures describe QCD physics studies over the period 1992--1996 from data taken with collisions of 27 GeV electrons and positrons with 820 GeV protons at the HERA collider at DESY by the two general-purpose detectors H1 and ZEUS. The focus of these lectures is on structure functions and jet production in deep inelastic scattering, photoproduction, and diffraction. The topics covered start with a general introduction to HERA and ep scattering. Structure functions are discussed. This includes the parton model, scaling violation, and the extraction of F 2 , which is used to determine the gluon momentum distribution. Both low and high Q 2 regimes are discussed. The low Q 2 transition from perturbative QCD to soft hadronic physics is examined. Jet production in deep inelastic scattering to measure α s , and in photoproduction to study resolved and direct photoproduction, is also presented. This is followed by a discussion of diffraction that begins with a general introduction to diffraction in hadronic collisions and its relation to ep collisions, and moves on to deep inelastic scattering, where the structure of diffractive exchange is studied, and in photoproduction, where dijet production provides insights into the structure of the Pomeron. 95 refs., 39 figs

QCD studies in ep collisions

Energy Technology Data Exchange (ETDEWEB)

Smith, W.H. [Univ. of Wisconsin, Madison, WI (United States). Physics Dept.

1997-06-01

These lectures describe QCD physics studies over the period 1992--1996 from data taken with collisions of 27 GeV electrons and positrons with 820 GeV protons at the HERA collider at DESY by the two general-purpose detectors H1 and ZEUS. The focus of these lectures is on structure functions and jet production in deep inelastic scattering, photoproduction, and diffraction. The topics covered start with a general introduction to HERA and ep scattering. Structure functions are discussed. This includes the parton model, scaling violation, and the extraction of F{sub 2}, which is used to determine the gluon momentum distribution. Both low and high Q{sup 2} regimes are discussed. The low Q{sup 2} transition from perturbative QCD to soft hadronic physics is examined. Jet production in deep inelastic scattering to measure {alpha}{sub s}, and in photoproduction to study resolved and direct photoproduction, is also presented. This is followed by a discussion of diffraction that begins with a general introduction to diffraction in hadronic collisions and its relation to ep collisions, and moves on to deep inelastic scattering, where the structure of diffractive exchange is studied, and in photoproduction, where dijet production provides insights into the structure of the Pomeron. 95 refs., 39 figs.

Numerical simulation on reasonable hole-sealing depth of boreholes for gas extraction

Science.gov (United States)

Zhao, Dan; Pan, Jingtao

2018-04-01

the fluid wall-type hole-sealing technology based on solid-liquid coupling to increase the hole-sealing length to 12 m were compared. The comparison results revealed that the pure extraction amount of gas from a single borehole in the No. 2 coal reservoir of Wangjialing Coalmine was improved by 4˜6 times. In addition, the concentration of extracted gas increased from less than 1% under the traditional hole-sealing mode to 20%˜25%, with an increase of more than 20 times. The extraction effect of the No. 2 coal reservoir of the coal mine was significantly enhanced by employing the fluid-wall-type hole-sealing technology based on solid-liquid coupling.

Numerical simulation on reasonable hole-sealing depth of boreholes for gas extraction

Directory of Open Access Journals (Sweden)

Dan Zhao

2018-04-01

before and after using the fluid wall-type hole-sealing technology based on solid-liquid coupling to increase the hole-sealing length to 12 m were compared. The comparison results revealed that the pure extraction amount of gas from a single borehole in the No. 2 coal reservoir of Wangjialing Coalmine was improved by 4∼6 times. In addition, the concentration of extracted gas increased from less than 1% under the traditional hole-sealing mode to 20%∼25%, with an increase of more than 20 times. The extraction effect of the No. 2 coal reservoir of the coal mine was significantly enhanced by employing the fluid-wall-type hole-sealing technology based on solid-liquid coupling.

Biometric analysis of the Arkhangelskiella group in the upper Campanian-Maastrichtian of the stevns-1 borehole, Denmark

DEFF Research Database (Denmark)

Thibault, Nicolas Rudolph

2010-01-01

The taxonomy of the calcareous nannofossil Arkhangelskiella is revised using the results of a biometric analysis performed on 599 specimens from various stratigraphic levels throughout the upper Campanian-Maastrichtian of the Stevns-1 borehole, Denmark. Combined qualitative labelling and biometric...... in the coccolith length and in the rim width, and that the central opening is an important additional parameter allowing distinction between the different morphogroups. Biometric analysis shows, however, that the morphogroups are strongly overlapping on all measured parameters. Therefore, the three distinct...

[Randomized clinical trial of IEP and EP regimens in the treatment of patients with small cell lung cancer].

Science.gov (United States)

Zhou, Hui; Wang, Anlan; Huang, Zhihua; Zhou, Wenwei

2004-06-20

To observe and compare the efficacy and safety of IEP and EP regimens for small cell lung cancer (SCLC). Sixty-four patients with SCLC pathologically proved were randomly divided into IEP group ( n =32) and EP group ( n =32). All the 64 patients were evaluable for response and toxicity. In IEP group, the total responsive rate, responsive rates of limited-stage patients and extensive-stage patients were 84.4%(27/32), 100.0%(15/15) and 70.6%(12/17) respectively; while in EP group, those were 75.0%(24/32), 85.7%(12/14) and 66.7% (12/18) respectively. The median duration of remission was 6 months and 1-year survival rate was 62.5% in IEP group, and 5 months and 56.2% in EP group. There was no significant difference in response rate, median duration of remission and 1-year survival between the two groups ( P > 0.05). The main toxicity was myelosuppression. Incidences of leukopenia at grade III-IV, nausea, vomiting and alopecia were significantly higher in the IEP arm than those in the EP arm ( P IEP and EP. IEP regimen shows a similar response rate compared with EP regimen. They might be considered as relevant regimens in initial patients with small cell lung cancer.

Does deep borehole disposal of HLRW has a chance in Germany?

Energy Technology Data Exchange (ETDEWEB)

Bracke, Guido [GRS gGmbH, Koeln (Germany); Charlier, Frank [RWTH Aachen (Germany). Nukleare Entsorgung und Techniktransfer; Liebscher, Axel [Helmholtz Centre Potsdam (Germany). GFZ German Research Centre for Geosciences; Schilling, Frank [KIT - Technical Univ. Karlsruhe (Germany). Inst. for Applied Geosciences; Roeckel, Thomas [Piewak und Partner, Bayreuth (Germany)

2017-01-15

Using deep boreholes for disposal of high-level radioactive waste (HLRW) can take advantage of multiple geologic barriers as safety features. The great depth efficiently prolongs or hinders radionuclide transport and also impedes proliferation. The number of boreholes could be less than 100 for the volume of HLRW in Germany. Using a simplified, generic safety concept minimum requirements for the diameter of boreholes and containers are derived. Furthermore the operational safety of emplacement, retrieval of waste and sealing of the boreholes is considered. This concept is assessed for its compliance with the safety requirements of the BMUB and the requirements and criteria for site selection defined by the commission ''Storage of high-level radio active waste''.

Cost-Effective Reciprocating Engine Emissions Control and Monitoring for E&P Field and Gathering Engines

Energy Technology Data Exchange (ETDEWEB)

Kirby S. Chapman; Sarah R. Nuss-Warren

2007-02-01

The objective of this project is to identify, develop, test, and commercialize emissions control and monitoring technologies that can be implemented by exploration and production (E&P) operators to significantly lower the cost of environmental compliance and expedite project permitting. The project team takes considerable advantage of the emissions control research and development efforts and practices that have been underway in the gas pipeline industry for the last 12 years. These efforts and practices are expected to closely interface with the E&P industry to develop cost-effective options that apply to widely-used field and gathering engines, and which can be readily commercialized. The project is separated into two phases. Phase 1 work establishes an E&P industry liaison group, develops a frequency distribution of installed E&P field engines, and identifies and assesses commercially available and emerging engine emissions control and monitoring technologies. Current and expected E&P engine emissions and monitoring requirements are reviewed, and priority technologies are identified for further development. The identified promising technologies are tested on a laboratory engine to confirm their generic viability. In addition, a full-scale field test of prototype emissions controls will be conducted on at least ten representative field engine models with challenging emissions profiles. Emissions monitoring systems that are integrated with existing controls packages will be developed. Technology transfer/commercialization is expected to be implemented through compressor fleet leasing operators, engine component suppliers, the industry liaison group, and the Petroleum Technology Transfer Council. This topical report discusses work completed during Phase 1 of the project Cost Effective Reciprocating Engine Emissions Control and Monitoring for E&P Field and Gathering Engines. In this report information, data, and results are compiled and summarized from quarterly

the use of statistical grain-size method in analysing borehole

African Journals Online (AJOL)

of medium-coarse grained sandstones, sub-angular to sub-rounded ... rainy season. Figure 1: Nsukka section of the Nsukka-Okigwe Cuesta. 6 0. 8 0. 100. 120. 140 ...... and also to improve the quality of drinking water, several boreholes were ...

Who Will Use Pre-Exposure Prophylaxis (PrEP) and Why?: Understanding PrEP Awareness and Acceptability amongst Men Who Have Sex with Men in the UK--A Mixed Methods Study.

Science.gov (United States)

Frankis, Jamie; Young, Ingrid; Flowers, Paul; McDaid, Lisa

2016-01-01

Recent clinical trials suggest that pre-exposure prophylaxis (PrEP) may reduce HIV transmission by up to 86% for men who have sex with men (MSM), whilst relatively high levels of PrEP acceptability have been reported to date. This study examines PrEP awareness amongst sub-groups of MSM communities and acceptability amongst MSM in a low prevalence region (Scotland, UK), using a mixed methods design. Quantitative surveys of n = 690 MSM recruited online via social and sociosexual media were analysed using descriptive statistics and multivariate logistic regression. In addition, n = 10 in-depth qualitative interviews with MSM were analysed thematically. Under one third (29.7%) of MSM had heard of PrEP, with awareness related to living in large cities, degree level education, commercial gay scene use and reporting an HIV test in the last year. Just under half of participants (47.8%) were likely to use PrEP if it were available but there was no relationship between PrEP acceptability and previous PrEP awareness. Younger men (18-25 years) and those who report higher risk UAI were significantly more likely to say they would use PrEP. Qualitative data described specific PrEP scenarios, illustrating how risk, patterns of sexual practice and social relationships could affect motivation for and nature of PrEP use. These findings suggest substantial interest PrEP amongst MSM reporting HIV risk behaviours in Scotland. Given the Proud results, there is a strong case to investigate PrEP implementation within the UK. However, it appears that disparities in awareness have already emerged along traditional indicators of inequality. Our research identifies the need for comprehensive support when PrEP is introduced, including a key online component, to ensure equity of awareness across diverse MSM communities (e.g. by geography, education, gay scene use and HIV proximity), as well as to responding to the diverse informational and sexual health needs of all MSM communities.

Who Will Use Pre-Exposure Prophylaxis (PrEP and Why?: Understanding PrEP Awareness and Acceptability amongst Men Who Have Sex with Men in the UK--A Mixed Methods Study.

Directory of Open Access Journals (Sweden)

Jamie Frankis

Full Text Available Recent clinical trials suggest that pre-exposure prophylaxis (PrEP may reduce HIV transmission by up to 86% for men who have sex with men (MSM, whilst relatively high levels of PrEP acceptability have been reported to date. This study examines PrEP awareness amongst sub-groups of MSM communities and acceptability amongst MSM in a low prevalence region (Scotland, UK, using a mixed methods design.Quantitative surveys of n = 690 MSM recruited online via social and sociosexual media were analysed using descriptive statistics and multivariate logistic regression. In addition, n = 10 in-depth qualitative interviews with MSM were analysed thematically.Under one third (29.7% of MSM had heard of PrEP, with awareness related to living in large cities, degree level education, commercial gay scene use and reporting an HIV test in the last year. Just under half of participants (47.8% were likely to use PrEP if it were available but there was no relationship between PrEP acceptability and previous PrEP awareness. Younger men (18-25 years and those who report higher risk UAI were significantly more likely to say they would use PrEP. Qualitative data described specific PrEP scenarios, illustrating how risk, patterns of sexual practice and social relationships could affect motivation for and nature of PrEP use.These findings suggest substantial interest PrEP amongst MSM reporting HIV risk behaviours in Scotland. Given the Proud results, there is a strong case to investigate PrEP implementation within the UK. However, it appears that disparities in awareness have already emerged along traditional indicators of inequality. Our research identifies the need for comprehensive support when PrEP is introduced, including a key online component, to ensure equity of awareness across diverse MSM communities (e.g. by geography, education, gay scene use and HIV proximity, as well as to responding to the diverse informational and sexual health needs of all MSM communities.

Living with encapsulating peritoneal sclerosis (EPS): the patient's perspective.

Science.gov (United States)

Hurst, Helen; Summers, Angela; Beaver, Kinta; Caress, Ann-Louise

2014-01-01

Although relatively rare, encapsulating peritoneal sclerosis (EPS) is nonetheless a major concern within the renal community. Risk of developing EPS is associated with long-term peritoneal dialysis (PD). High mortality was previously reported, although surgery has since improved outcomes. Research into EPS focuses on imaging and early detection methods, genetics, biomarkers and preventive strategies. No previous studies have examined patients' experiences of EPS. The aim of the present study was to explore the experience of patients who have undergone surgery for EPS in one center in the North of England. A qualitative phenomenological approach, involving in-depth interviews, was adopted. Nine participants were recruited out of a total of 18 eligible. Most participants were interviewed twice over a 12-month period (October 2009 to October 2010). Interpretive data analysis was conducted, following the philosophical tradition of hermeneutics, to draw out themes from the data. Data collection and analysis took place concurrently and participants were sent a summary of their first interview to allow a period of reflection prior to the subsequent interview. EPS presented the most serious challenge participants had faced since developing chronic kidney disease (CKD). Three major themes were identified, each with subcategories. The key issues for patients were related to identification of early symptoms and lack of understanding. The patients' sense of 'not being heard' by health care professionals led to a loss of trust and enhanced their feelings of uncertainty. The enormity of the surgery, the suffering, and what they had to endure had an enormous impact, but an overriding aspect of this experience was also the loss they felt for their independence and for the PD therapy over which they had control. The findings of this study highlight a number of important issues relevant to clinical practice, including lack of information and understanding of EPS, particularly its

Room Q data report: Test borehole data from April 1989 through November 1991

International Nuclear Information System (INIS)

Jensen, A.L.; Howard, C.L.; Jones, R.L.; Peterson, T.P.

1993-03-01

Pore-pressure and fluid-flow tests were performed in 15 boreholes drilled into the bedded evaporites of the Salado Formation from within the Waste Isolation Pilot Plant (WIPP). The tests measured fluid flow and pore pressure within the Salado. The boreholes were drilled into the previously undisturbed host rock around a proposed cylindrical test room, Room Q, located on the west side of the facility about 655 m below ground surface. The boreholes were about 23 m deep and ranged over 27.5 m of stratigraphy. They were completed and instrumented before excavation of Room Q. Tests were conducted in isolated zones at the end of each borehole. Three groups of 5 isolated zones extend above, below, and to the north of Room Q at increasing distances from the room axis. Measurements recorded before, during, and after the mining of the circular test room provided data about borehole closure, pressure, temperature, and brine seepage into the isolated zones. The effects of the circular excavation were recorded. This data report presents the data collected from the borehole test zones between April 25, 1989 and November 25, 1991. The report also describes test development, test equipment, and borehole drilling operations

OMEGA EP: High-energy peta-watt capability for the OMEGA laser facility

Energy Technology Data Exchange (ETDEWEB)

Kelly, J.H.; Waxer, L.J.; Bagnoud, V.; Begishev, I.A.; Bromage, J.; Kruschwitz, B.E.; Kessler, T.J.; Loucks, S.J.; Maywar, D.N.; McCrory, R.L.; Meyerhofer, D.D.; Morse, S.F.B.; Oliver, J.B.; Rigatti, A.L.; Schmid, A.W.; Stoeckl, C.; Dalton, S.; Folnsbee, L.; Guardalben, M.J.; Jungquist, R.; Puth, J.; Shoup III, M.J.; Weiner, D.; Zuegel, J.D. [Rochester Univ., Lab. for Laser Energetics, NY (United States)

2006-06-15

OMEGA EP (Extended Performance) is a peta-watt-class addition to the existing 30-kJ, 60-beam OMEGA Laser Facility at the University of Rochester. When completed, it will consist of four beamlines, each capable of producing up to 6.5 kJ at 351 nm in a 1 to 10 ns pulse. Two of the beamlines will produce up to 2.6 kJ in a pulse-width range of 1 to 100 ps at 1053 nm using chirped-pulse amplification (CPA). This paper reviews both the OMEGA EP performance objectives and the enabling technologies required to meet these goals. (authors)

OMEGA EP: High-energy peta-watt capability for the OMEGA laser facility

International Nuclear Information System (INIS)

Kelly, J.H.; Waxer, L.J.; Bagnoud, V.; Begishev, I.A.; Bromage, J.; Kruschwitz, B.E.; Kessler, T.J.; Loucks, S.J.; Maywar, D.N.; McCrory, R.L.; Meyerhofer, D.D.; Morse, S.F.B.; Oliver, J.B.; Rigatti, A.L.; Schmid, A.W.; Stoeckl, C.; Dalton, S.; Folnsbee, L.; Guardalben, M.J.; Jungquist, R.; Puth, J.; Shoup III, M.J.; Weiner, D.; Zuegel, J.D.

2006-01-01

OMEGA EP (Extended Performance) is a peta-watt-class addition to the existing 30-kJ, 60-beam OMEGA Laser Facility at the University of Rochester. When completed, it will consist of four beamlines, each capable of producing up to 6.5 kJ at 351 nm in a 1 to 10 ns pulse. Two of the beamlines will produce up to 2.6 kJ in a pulse-width range of 1 to 100 ps at 1053 nm using chirped-pulse amplification (CPA). This paper reviews both the OMEGA EP performance objectives and the enabling technologies required to meet these goals. (authors)

An isotopic and fluid inclusion study of fracture calcite from borehole OL-KR1 at the Olkiluoto site, Finland

International Nuclear Information System (INIS)

Blyth, A.; Frape, S.; Blomqvist, R.; Nissinen, P.; McNutt, R.

1998-04-01

A study of the geochemistry of fracture filling calcite in borehole OL-KR1 at the radioactive waste disposal investigation site Olkiluoto (in Finland) was undertaken in 1998. The purpose of the present study is to characterize the fracture calcite using mineralogy, oxygen, carbon and strontium isotopes, and fluid inclusions in order to determine past and present chemical and isotopic condition at the site

An isotopic and fluid inclusion study of fracture calcite from borehole OL-KR1 at the Olkiluoto site, Finland

Energy Technology Data Exchange (ETDEWEB)

Blyth, A.; Frape, S. [Univ. of Waterloo, ON (Canada); Blomqvist, R.; Nissinen, P. [Geological Survey of Finland, Espoo (Finland); McNutt, R. [McMaster Univ. of Hamilton, ON (Canada)

1998-04-01

A study of the geochemistry of fracture filling calcite in borehole OL-KR1 at the radioactive waste disposal investigation site Olkiluoto (in Finland) was undertaken in 1998. The purpose of the present study is to characterize the fracture calcite using mineralogy, oxygen, carbon and strontium isotopes, and fluid inclusions in order to determine past and present chemical and isotopic condition at the site 39 refs.

Investigation of sulphide in core drilled boreholes KLX06, KAS03 and KAS09 at Laxemar and Aespoe Chemical-, microbiological- and dissolved gas data from groundwater in four borehole sections

Energy Technology Data Exchange (ETDEWEB)

Rosdahl, Anette (Geosigma AB (Sweden)); Pedersen, Karsten; Hallbeck, Lotta (Microbial Analytics Sweden AB (Sweden)); Wallin, Bill (Geokema AB (Sweden))

2011-01-15

This report describes a study performed during 2009 which focused on the production of sulphide (microbial sulphate reduction) in deep groundwater that was implemented in the core drilled boreholes KLX06, -475 to 482 meter above sea level, m a s l, KAS03,-97 to 241 and -613 to 984 m a s l, and KAS09, -96 to -125 m a s l, at Laxemar and Aspo. The study aimed to increase knowledge of background groundwater levels of sulphide and its variations in time and space through the analysis of sulphide and parameters related to sulphide production. Sampling of groundwater was conducted in three core drilled boreholes of varying age as time series with continuous pumping and as single samples. The analysis program covered chemical parameters (pH, chloride, sulphate, iron, and organic carbon), dissolved gas composition, stable isotopes in groundwater (delta2H, delta18O, delta34S, delta13C), stable isotopes of gaseous compounds (delta2H, delta13C, delta18O), microbiological parameters (sulphate- and iron reducing bacteria, SRB and IRB), phthalates and low molecular mass organic acids (LMMOA). The sampling in KLX06 was carried out as time series with a 9 week pause in pumping. When the water volume discharged was about 150 times that of the packer-isolated borehole section, sulphides decreased from 7 mg L-1 to 0.05 mg L-1 and the salinity increased from 740 to 1,480 mg L-1. After a 9 weeks pause in pumping, the sulphide concentration and salinity again approached the original values, i.e. 7 mg L-1 of sulphide and 450 mg L-1 of chloride. The SRB and IRB showed high concentrations that were reduced during pumping in the borehole. The water in the standpipe which has a different water composition than the groundwater, also showed similar high concentrations of sulphide and SRB. The standpipe is a plastic pipe in the wider upper part of the borehole; connected with the tube from the packer of the borehole section and used to accommodate a filter and a groundwater pump when collecting

Investigation of sulphide in core drilled boreholes KLX06, KAS03 and KAS09 at Laxemar and Aespoe: Chemical-, microbiological- and dissolved gas data from groundwater in four borehole sections

International Nuclear Information System (INIS)

Rosdahl, Anette; Pedersen, Karsten; Hallbeck, Lotta; Wallin, Bill

2011-01-01

This report describes a study performed during 2009 which focused on the production of sulphide (microbial sulphate reduction) in deep groundwater that was implemented in the core drilled boreholes KLX06, -475 to 482 meter above sea level, m a s l, KAS03,-97 to 241 and -613 to 984 m a s l, and KAS09, -96 to -125 m a s l, at Laxemar and Aspo. The study aimed to increase knowledge of background groundwater levels of sulphide and its variations in time and space through the analysis of sulphide and parameters related to sulphide production. Sampling of groundwater was conducted in three core drilled boreholes of varying age as time series with continuous pumping and as single samples. The analysis program covered chemical parameters (pH, chloride, sulphate, iron, and organic carbon), dissolved gas composition, stable isotopes in groundwater (δ 2 H, δ 18 O, δ 34 S, δ 13 C), stable isotopes of gaseous compounds (δ 2 H, δ 13 C, δ 18 O), microbiological parameters (sulphate- and iron reducing bacteria, SRB and IRB), phthalates and low molecular mass organic acids (LMMOA). The sampling in KLX06 was carried out as time series with a 9 week pause in pumping. When the water volume discharged was about 150 times that of the packer-isolated borehole section, sulphides decreased from 7 mg L -1 to 0.05 mg L -1 and the salinity increased from 740 to 1,480 mg L -1 . After a 9 weeks pause in pumping, the sulphide concentration and salinity again approached the original values, i.e. 7 mg L -1 of sulphide and 450 mg L -1 of chloride. The SRB and IRB showed high concentrations that were reduced during pumping in the borehole. The water in the standpipe which has a different water composition than the groundwater, also showed similar high concentrations of sulphide and SRB. The standpipe is a plastic pipe in the wider upper part of the borehole; connected with the tube from the packer of the borehole section and used to accommodate a filter and a groundwater pump when collecting

Functional and bioinformatics analysis of an exopolysaccharide-related gene (epsN) from Lactobacillus kefiranofaciens ZW3.

Science.gov (United States)

Wang, Jingrui; Tang, Wei; Zheng, Yongna; Xing, Zhuqing; Wang, Yanping

2016-09-01

A novel lactic acid bacteria strain Lactobacillus kefiranofaciens ZW3 exhibited the characteristics of high production of exopolysaccharide (EPS). The epsN gene, located in the eps gene cluster of this strain, is associated with EPS biosynthesis. Bioinformatics analysis of this gene was performed. The conserved domain analysis showed that the EpsN protein contained MATE-Wzx-like domains. Then the epsN gene was amplified to construct the recombinant expression vector pMG36e-epsN. The results showed that the EPS yields of the recombinants were significantly improved. By determining the yields of EPS and intracellular polysaccharide, it was considered that epsN gene could play its Wzx flippase role in the EPS biosynthesis. This is the first time to prove the effect of EpsN on L. kefiranofaciens EPS biosynthesis and further prove its functional property.

[Detection and clinical value of epithelial cellular adhesion molecule (EpCAM) mRNA positive circulating tumor cells in metastatic breast cancer].

Science.gov (United States)

Yan, Ying; Cheng, Jian-ping; Di, Li-jun; Song, Guo-hong; Ren, Jun

2012-04-18

To test for circulating tumor cells (CTCs) relying on epithelial cellular adhesion molecule (EpCAM) expression in metastatic breast cancer by quantitative real-time reverse transcription-PCR. In the study,47 metastatic breast cancer patients were evaluated by quantitative real-time PCR for detecting EpCAM mRNA. In addition, analyses were carried out for their correlation with patients' clinicopathologic features, response, and the time to progression (TTP). The sensitivity of EpCAM mRNA in the metastatic breast cancer patients was about 40%. However, the specificity of EpCAM mRNA for 20 healthy controls was 100%. TTP was calculated, and compared with that between EpCAM mRNA-positive and EpCAM mRNA-negative groups. For the retrospective study, the median TTP was 7.1 months and 11.1 months (P=0.013) for patients with EpCAM mRNA-positive and EpCAM mRNA-negative, respectively, after the first cycle chemotherapy. Moreover, a statistically significant correlation was demonstrated between EpCAM mRNA and TTP in patients who underwent the first or the second-line chemotherapy (P=0.018), but there was no significance in the patients pretreated with two or more previous chemotherapy lines (P=0.471). This study provides evidence of the presence of EpCAM mRNA in approximately 40% of patients with metastatic breast cancer. There is a strong correlation between EpCAM mRNA results after the first cycle therapy and TTP in metastatic breast cancer patients, and EpCAM mRNA positive after chemotherapy may predict shorter TTP.

Effect of fluid-filled boreholes on resistivity tomography; Hiteiko tomography ni okeru konaisui no eikyo

Energy Technology Data Exchange (ETDEWEB)

Sugimoto, Y [DIA Consultants Co. Ltd., Tokyo (Japan)

1997-10-22

Theoretical discussions were given on the effect of fluid-filled boreholes on resistivity tomography. The discussions performed incorporation of earth resistance as a method to consider borehole diameters in an FEM calculation using wire elements. The numerical experiment conducted a simulation on the following two objects: resistivity tomography in a horizontal multi-layer structure consisted of layers with resistivity ranging from 10 to 10000 ohm-m, and a model with a slanted low resistivity band existing in a background of 5000 ohm-m. As a result of the discussions, it was made clear that the effect of the boreholes can be corrected by giving earth resistance between the wire elements and natural ground. An improved potential calculating program indicated that the effect of the fluid-filled boreholes in the resistivity tomography generates false images with high resistivity along the bores if the resistivity has high contrast. Incorporating the wire elements into an inverse analysis model reduces the false images and improves the accuracy. 1 ref., 12 figs.

Method and apparatus for logging inclined earth boreholes

International Nuclear Information System (INIS)

Youmans, A.H.

1981-01-01

An improved technique is provided for comparing the velocity of an elongated well logging instrument traversing an inclined earth borehole with the playout velocity of the well logging cable at the earth's surface to control both the cable hoist drum rotation and the rate of movement of the subsurface instrument and thus insure cable playout is in equilibrium with the logging instrument movement. Method and apparatus are described for detecting any reduction in movement of the logging instrument through the borehole and for reducing the velocity of the logging cable playout in response thereto by reducing drum rotation. Further, when the velocity of cable playout slows to a preselected value, a monitoring circuit generates control signals which actuate a means of power attached to or integral with the logging instrument which, upon initiation, apply a force to move the logging instrument upward or downward within the borehole

Damping the e-p instability in the SNS accumulator ring

Science.gov (United States)

Evans, N. J.; Deibele, C.; Aleksandrov, A.; Xie, Z.

2018-03-01

A broadband, digital damper system for both transverse planes developed for the SNS accumulator ring has recently damped the first indications of the broadband 50-150 MHz e-p instability in a 1.2 MW neutron production beam. This paper presents details of the design and operation of the SNS damper system as well as results of active damping of the e-p instability in the SNS ring showing a reduction in power of betatron oscillation over the 10-300 MHz band of up to 70%. The spectral content of the beam during operation, with and without the damper system is presented and performance of the damper system is evaluated.

Deep Borehole Emplacement Mode Hazard Analysis Revision 0

Energy Technology Data Exchange (ETDEWEB)

Sevougian, S. David [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2015-08-07

This letter report outlines a methodology and provides resource information for the Deep Borehole Emplacement Mode Hazard Analysis (DBEMHA). The main purpose is identify the accident hazards and accident event sequences associated with the two emplacement mode options (wireline or drillstring), to outline a methodology for computing accident probabilities and frequencies, and to point to available databases on the nature and frequency of accidents typically associated with standard borehole drilling and nuclear handling operations. Risk mitigation and prevention measures, which have been incorporated into the two emplacement designs (see Cochran and Hardin 2015), are also discussed. A key intent of this report is to provide background information to brief subject matter experts involved in the Emplacement Mode Design Study. [Note: Revision 0 of this report is concentrated more on the wireline emplacement mode. It is expected that Revision 1 will contain further development of the preliminary fault and event trees for the drill string emplacement mode.

Subseafloor seawater-basalt-microbe reactions: Continuous sampling of borehole fluids in a ridge flank environment

Science.gov (United States)

Wheat, C. Geoffrey; Jannasch, Hans W.; Fisher, Andrew T.; Becker, Keir; Sharkey, Jessica; Hulme, Samuel

2010-07-01

Integrated Ocean Drilling Program (IODP) Hole 1301A was drilled, cased, and instrumented with a long-term, subseafloor observatory (CORK) on the eastern flank of the Juan de Fuca Ridge in summer 2004. This borehole is located 1 km south of ODP Hole 1026B and 5 km north of Baby Bare outcrop. Hole 1301A penetrates 262 m of sediment and 108 m of the uppermost 3.5 Ma basaltic basement in an area of warm (64°C) hydrothermal circulation. The borehole was instrumented, and those instruments were recovered 4 years later. Here we report chemical data from two continuous fluid samplers (OsmoSamplers) and temperature recording tools that monitored changes in the state of borehole (formation) fluids. These changes document the effects of drilling, fluid overpressure and flow, seawater-basalt interactions, and microbial metababolic activity. Initially, bottom seawater flowed into the borehole through a leak between concentric CORK casing strings. Eventually, the direction of flow reversed, and warm, altered formation fluid flowed into the borehole and discharged at the seafloor. This reversal occurred during 1 week in September 2007, 3 years after drilling operations ceased. The composition of the formation fluid around Hole 1301A generally lies within bounds defined by springs on Baby Bare outcrop (to the south) and fluids that discharged from Hole 1026B (to the north); deviations likely result from reactions with drilling products. Simple conservative mixing of two end-member fluids reveals reactions occurring within the crust, including nitrate reduction presumably by denitrifying microbes. The observed changes in borehole fluid composition provide the foundation for a conceptual model of chemical and microbial change during recharge of a warm ridge-flank hydrothermal system. This model can be tested through future scientific ocean drilling experiments.

Predicting Seawater Intrusion in Coastal Groundwater Boreholes Using Self-Potential Data

Science.gov (United States)

Graham, M.; MacAllister, D. J.; Jackson, M.; Vinogradov, J.; Butler, A. P.

2017-12-01

Many coastal groundwater abstraction wells are under threat from seawater intrusion: this is exacerbated in summer by low water tables and increased abstraction. Existing hydrochemistry or geophysical techniques often fail to predict the timing of intrusion events. We investigate whether the presence and transport of seawater can influence self-potentials (SPs) measured within groundwater boreholes, with the aim of using SP monitoring to provide early warning of saline intrusion. SP data collection: SP data were collected from a coastal groundwater borehole and an inland borehole (> 60 km from the coast) in the Seaford Chalk of southern England. The SP gradient in the inland borehole was approximately 0.05 mV/m, while that in the coastal borehole varied from 0.16-0.26 mV/m throughout the monitoring period. Spectral analysis showed that semi-diurnal fluctuations in the SP gradient were several orders of magnitude higher at the coast than inland, indicating a strong influence from oceanic tides. A characteristic decrease in the gradient, or precursor, was observed in the coastal borehole several days prior to seawater intrusion. Modelling results: Hydrodynamic transport and geoelectric modelling suggest that observed pressure changes (associated with the streaming potential) are insufficient to explain either the magnitude of the coastal SP gradient or the semi-diurnal SP fluctuations. By contrast, a model of the exclusion-diffusion potential closely matches these observations and produces a precursor similar to that observed in the field. Sensitivity analysis suggests that both a sharp saline front and spatial variations in the exclusion efficiency arising from aquifer heterogeneities are necessary to explain the SP gradient observed in the coastal borehole. The presence of the precursor in the model depends also on the presence and depth of fractures near the base of the borehole. Conclusions: Our results indicate that SP monitoring, combined with hydrodynamic

Borehole tool outrigger arm displacement control mechanism

International Nuclear Information System (INIS)

Lee, A.G.

1985-01-01

As the outrigger arms of a borehole logging tool are flexed inwardly and outwardly according to the diameter of the borehole opening through which they pass, the corresponding axial displacements of the ends of the arms are controlled to determine the axial positions of the arms relative to the tool. Specifically, as the arm ends move, they are caused to rotate by a cam mechanism. The stiffness of the arms causes the arm ends to rotate in unison, and the exact positions of the arms on the tool are then controlled by the differential movements of the arm ends in the cams

Clinical significance of determination of levels of several cytokines (IL-1β, IL-2, IL-10 and TNF) in expressed prostatic fluid (EPS) from patients with various types of chronic prostatitis

International Nuclear Information System (INIS)

Gao Juxing; Zhang Jiyun

2006-01-01

Objective: To investigate the levels of several cytokines in EPS from patients with different types of chronic prostatitis. Methods: The EPS levels of IL-1β, IL-2, IL-10 and TNF were determined with RIA in 86 patients with various types of chronic prostatitis as well as in 30 controls. Results: The EPS levels of IL-1β, IL-2 and TNF in all the 86 patients with various types of chronic prostatitis were significantly higher than those in the controls (P 10/HP, lecithin body < + +) (n=31) were significantly higher than those in patients with CPPS IIIB (WRC < 10/HP, lecithin body normal, n=29)(P<0.05 or P<0.01 ), while the IL-10 levels were significantly lower (P<0.01). Conclusion: EPS levels of the cytokines IL-β, IL-2, TNF and IL-10 might be of value for diagnosis and classification of chronic prostatitis. (authors)

Safety and adherence to intermittent pre-exposure prophylaxis (PrEP) for HIV-1 in African men who have sex with men and female sex workers.

Science.gov (United States)