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Sample records for epidemiol biomarkers prev

  1. epidemiológica

    Directory of Open Access Journals (Sweden)

    Simón Barquera

    2005-01-01

    Full Text Available Una de las características de la transición epidemiológica y nutricional en México es el importante aumento en la prevalencia de la obesidad, siendo ésta el factor de riesgo modificable más importante para el desarrollo de las enfermedades crónicas no transmisibles que representan el principal problema de salud pública en el país actualmente. Estas enfermedades afectan no sólo a la población de altos ingresos, sino cada vez más a la de ingresos bajos, y no solamente a grupos de población de edad avanzada, sino también a aquéllos en edad productiva. En este documento se realiza un análisis de las principales características de la transición epidemiológica y nutricional en México (magnitud, distribución, determinantes, asociaciones y complicaciones, utilizando para ello encuestas nacionales y haciendo énfasis en las enfermedades crónicas asociadas a la nutrición.

  2. Long-term Diet and Biomarker Changes after a Short-term Intervention among Hispanic Breast Cancer Survivors: The ¡Cocinar Para Su Salud! Randomized Controlled Trial.

    Science.gov (United States)

    Greenlee, Heather; Ogden Gaffney, Ann; Aycinena, A Corina; Koch, Pam; Contento, Isobel; Karmally, Wahida; Richardson, John M; Shi, Zaixing; Lim, Emerson; Tsai, Wei-Yann; Santella, Regina M; Blaner, William S; Clugston, Robin D; Cremers, Serge; Pollak, Susan; Sirosh, Iryna; Crew, Katherine D; Maurer, Matthew; Kalinsky, Kevin; Hershman, Dawn L

    2016-11-01

    Among Hispanic breast cancer survivors, we examined the long-term effects of a short-term culturally based dietary intervention on increasing fruits/vegetables (F/V), decreasing fat, and changing biomarkers associated with breast cancer recurrence risk. Spanish-speaking women (n = 70) with a history of stage 0-III breast cancer who completed treatment were randomized to ¡Cocinar Para Su Salud! (n = 34), a culturally based 9-session program (24 hours over 12 weeks, including nutrition education, cooking classes, and food-shopping field trips), or a control group (n = 36, written dietary recommendations for breast cancer survivors). Diet recalls, fasting blood, and anthropometric measures were collected at baseline, 6, and 12 months. We report changes between groups at 12 months in dietary intake and biomarkers using 2-sample Wilcoxon t tests and generalized estimating equation (GEE) models. At 12 months, the intervention group compared with the control group reported higher increases in mean daily F/V servings (total: +2.0 vs. -0.4; P Salud! program was effective at increasing long-term F/V intake in Hispanic breast cancer survivors and changed biomarkers associated with breast cancer recurrence risk. It is possible for short-term behavioral interventions to have long-term effects on behaviors and biomarkers in minority cancer patient populations. Results can inform future study designs. Cancer Epidemiol Biomarkers Prev; 25(11); 1491-502. ©2016 AACR. ©2016 American Association for Cancer Research.

  3. Optimalizácia monitorovania sieťovej prevádzky

    Directory of Open Access Journals (Sweden)

    František Jakab

    2013-06-01

    Full Text Available Tento príspevok sa zaoberá otvorenými problémami vyskytujúcimi sa pri pasívnom prístupe merania sieťových charakteristík. Opisuje najpoužívanejšie prístupy merania sieťových parametrov ako aj charakteristiky, ktoré sa pri monitorovaní najčastejšie sledujú. Hlavným cieľom tohto príspevku je predstavenie konceptuálneho návrhu riešenia opísaných problémov, ktorý by sa mal docieliť automatizovaným prispôsobením exportu záznamov o tokoch prevádzky k aktuálnemu stavu siete.

  4. Investing in mental health and well-being: findings from the DataPrev project

    Science.gov (United States)

    Mcdaid, David; Park, A-La

    2011-01-01

    A systematic review was conducted to determine the extent to which an economic case has been made in high-income countries for investment in interventions to promote mental health and well-being. We focused on areas of interest to the DataPrev project: early years and parenting interventions, actions set in schools and workplaces and measures targeted at older people. Economic evaluations had to have some focus on promotion of mental health and well-being and/or primary prevention of poor mental health through health-related means. Studies preventing exacerbations in existing mental health problems were excluded, with the exception of support for parents with mental health problems, which might indirectly affect the mental health of their children. Overall 47 studies were identified. There was considerable variability in their quality, with a variety of outcome measures and different perspectives: societal, public purse, employer or health system used, making policy comparisons difficult. Caution must therefore be exercised in interpreting results, but the case for investment in parenting and health visitor-related programmes appears most strong, especially when impacts beyond the health sector are taken into account. In the workplace an economic return on investment in a number of comprehensive workplace health promotion programmes and stress management projects (largely in the USA) was reported, while group-based exercise and psychosocial interventions are of potential benefit to older people. Many gaps remain; a key first step would be to make more use of the existence evidence base on effectiveness and model mid- to long-term costs and benefits of action in different contexts and settings. PMID:22079932

  5. Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study.

    Science.gov (United States)

    Cook, Penny A; Morleo, Michela; Billington, David; Sanderson-Shortt, Kevin; Jones, Colin; Gabbay, Mark; Sheron, Nick; Bellis, Mark A; Phillips-Howard, Penelope A; Gilmore, Ian T

    2015-06-04

    The direct cost of excessive alcohol consumption to health services is substantial but dwarfed by the cost borne by the workplace as a result of lost productivity. The workplace is also a promising setting for health interventions. The Preventing Alcohol Harm in Liverpool and Knowsley (PrevAIL) project aimed to evaluate a mechanism for detecting the prevalence of alcohol related liver disease using fibrosis biomarkers. Secondary aims were to identify the additive effect of obesity as a risk factor for early liver disease; to assess other impacts of alcohol on work, using a cross-sectional survey. Participants (aged 36-55 y) from 13 workplaces participated (March 2011-April 2012). BMI, waist circumference, blood pressure and self-reported alcohol consumption in the previous week was recorded. Those consuming more than the accepted UK threshold (men: >21 units; female: >14 units alcohol) provided a 20 ml venous blood sample for a biomarker test (Southampton Traffic Light Test) and completed an alcohol questionnaire (incorporating the Severity of Alcohol Dependence Questionnaire). The screening mechanism enrolled 363 individuals (52 % women), 39 % of whom drank above the threshold and participated in the liver screen (n = 141, complete data = 124 persons). Workplaces with successful participation were those where employers actively promoted, encouraged and facilitated attendance. Biomarkers detected that 30 % had liver disease (25 %, intermediate; 5 % probable). Liver disease was associated with the frequency of visits to the family physician (P = 0.036) and obesity (P = 0.052). The workplace is an important setting for addressing alcohol harm, but there are barriers to voluntary screening that need to be addressed. Early detection and support of cases in the community could avert deaths and save health and social costs. Alcohol and obesity should be addressed simultaneously, because of their known multiplicative effect on liver disease risk, and because employers

  6. Comparison of Biomarkers of Tobacco Exposure between Premium and Discount Brand Cigarette Smokers in the NHANES 2011-2012 Special Sample.

    Science.gov (United States)

    Wasserman, Emily J; Reilly, Samantha M; Goel, Reema; Foulds, Jonathan; Richie, John P; Muscat, Joshua E

    2018-05-01

    Background: Increased cigarette costs have inadvertently strengthened the appeal of discounted brands to price-sensitive smokers. Although smokers perceive discounted brands as having poorer quality, little is known about their delivery of toxic tobacco smoke constituents compared with premium-branded tobacco products. Methods: We investigated the differences between discount and premium brand smokers using the National Health and Nutrition Examination Survey 2011-2012 Special Smoker Sample. Our analyses focused on demographic differences and 27 biomarkers of harmful and potentially harmful constituents (HPHC) listed by the FDA, including volatile organic compounds, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronide [4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol glucuronide; reported as total NNAL (tNNAL)], metals, and polycyclic aromatic hydrocarbons (PAHs). Data were analyzed using linear regression models adjusting for potential confounders. Results: A total of 976 non-tobacco users and 578 recent cigarette smokers were eligible for analysis, of which 141 (26.0% weighted) smoked discount brand cigarettes and 437 (74.0% weighted) smoked premium. Discount brand smokers were older, predominantly non-Hispanic white, and had higher serum cotinine. Discount brand smokers had significantly higher levels of 13 smoking-related biomarkers, including tNNAL, uranium, styrene, xylene, and biomarkers of exposure to PAHs (naphthalene, fluorene, and phenanthrene), compared with premium brand smokers. Conclusions: These findings suggest that discount cigarette use is associated with higher exposure to several carcinogenic and toxic HPHCs. Impact: These results may have important regulatory implications for product standards, as higher exposures could lead to a greater degree of harm. Cancer Epidemiol Biomarkers Prev; 27(5); 601-9. ©2018 AACR . ©2018 American Association for Cancer Research.

  7. Envelhecimento, depressão e quedas: um estudo com os participantes do Projeto Prev-Quedas

    Directory of Open Access Journals (Sweden)

    Hugo Leonardo Prata

    Full Text Available INTRODUÇÃO: No Brasil a depressão é um problema de saúde pública, tendo 10 milhões de pessoas com esse diagnóstico. A queda de idosos é outro comprometedor da saúde, que muitas vezes apresenta uma combinação com a depressão. OBJETIVOS: Verificar a associação entre estados depressivos e número de quedas. MATERIAIS E MÉTODOS: Estudo seccional em que foi aplicado o GDS-15 e um questionário específico. Os dados foram trabalhados no programa R pelo teste Qui-Quadrado, ao nível de significância de 95%. Foram incluídas idosas que participam do Projeto Prev-Quedas e o critério de exclusão foi apresentar deficiência auditiva não corrigida ou apresentar estágios avançados de distúrbios cognitivos e/ou doenças mentais que impedissem o entendimento das perguntas. DISCUSSÃO E RESULTADOS: Foram entrevistadas 78 idosas, com idade média de 72 anos. O percentual de pessoas com possível quadro de depressão foi de 21,8%. Não foi encontrada associação entre depressão e as variáveis idade, estado civil, morar com alguém (p > 0,05. Foi encontrada associação entre quedas e depressão (p < 0,01. CONCLUSÃO: A tendência a estados depressivos encontrada na amostra foi considerada alta, acima da média nacional observada em 1999. A associação encontrada entre o quadro de depressão e um maior número de quedas sofridas pelos participantes pode indicar a necessidade de maior atenção das políticas públicas ao problema. A ausência de medidas preventivas estaria ligada ao pior padrão de qualidade de vida relacionada à saúde.

  8. Diagnóstico del comportamiento epidemiológico de la diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Gabriel Trujillo

    2001-04-01

    Full Text Available

    La diabetes mellitus es un trastorno metabólico que induce un estado de desequilibrio orgánico, el cual causa serias complicaciones, con un alto grado de discapacidad funcional, no sólo física y personal sino también emocional y familiar. En Colombia figura entre las primeras diez causas de consulta
    ambulatoria y de ingresos hospitalarios en la población mayor de 45 años. También ocupa los primeros diez lugares entre las causas de muerte, y es la primera causa de amputación luego del uso de las minas antipersonales; también es la primera causa de enfermedad renal y de ceguera en el mundo. Estudios realizados entre la población urbana de estratos 1 a 3 indican una prevalencia del 7%, mientras que entre la población rural es sólo del 1,5%, y se han encontrado cifras aún menores entre la población indígena. Se prevé un incremento de la prevalencia para este nuevo siglo, proyectado en el crecimiento industrial y poblacional, además de la inversión de la pirámide poblacional, la cual muestra un aumento del promedio de vida. En Estados Unidos el manejo de las complicaciones y su tratamiento
    ha superado en costos a entidades como el cáncer, las enfermedades del corazón, el SIDA y el alcoholismo.
    Por las razones anteriormente expuestas, el presente estudio estará dirigido a hacer un diagnóstico del comportamiento epidemiológico de la DM, que sirva como base para el diseño de una campaña de prevención para evitar sus complicaciones.

     

  9. Vigilancia epidemiológica del estado de salud bucal

    OpenAIRE

    . Amado Rodríguez Calzadilla; . Carolina Valiente Zaldívar

    1999-01-01

    Se exponen aspectos relacionados con la vigilancia epidemiológica del estado de salud bucal de la población general, con fines metodológicos. Se plantean los objetivos y las premisas para establecer el sistema de vigilancia, así como la caracterización de la comunidad basados en los elementos fundamentales para un sistema de vigilancia. Se pretende evaluar costo y calidad de la atención de la salud bucal para lograr el aprovechamiento eficiente de los recursos. Se realizarán investigaciones r...

  10. Prevención de la adicción a videojuegos: eficacia de las técnicas de control de la impulsividad en el programa PrevTec 3.1

    OpenAIRE

    Marco Puche, Clara

    2013-01-01

    Participaron 1.1106 alumnos de Educación Primaria y Secundaria de 13 centros educativos de la ciudad de Valencia y su área metropolitana. Se aplicó un diseño mixto o de medidas parcialmente repetidas, con una variable intra-sujeto –momento de medida- y una variable entre-sujetos –un grupo recibió las sesiones del programa PrevTec 3.1 (tradicional), otro recibió el programa con técnicas de control de la impulsividad adicionales, y un tercer grupo conformó el grupo en lista de espera-. Las ...

  11. Pharmacogenomic Biomarkers

    Directory of Open Access Journals (Sweden)

    Sandra C. Kirkwood

    2002-01-01

    Full Text Available Pharmacogenomic biomarkers hold great promise for the future of medicine and have been touted as a means to personalize prescriptions. Genetic biomarkers for disease susceptibility including both Mendelian and complex disease promise to result in improved understanding of the pathophysiology of disease, identification of new potential therapeutic targets, and improved molecular classification of disease. However essential to fulfilling the promise of individualized therapeutic intervention is the identification of drug activity biomarkers that stratify individuals based on likely response to a particular therapeutic, both positive response, efficacy, and negative response, development of side effect or toxicity. Prior to the widespread clinical application of a genetic biomarker multiple scientific studies must be completed to identify the genetic variants and delineate their functional significance in the pathophysiology of a carefully defined phenotype. The applicability of the genetic biomarker in the human population must then be verified through both retrospective studies utilizing stored or clinical trial samples, and through clinical trials prospectively stratifying patients based on the biomarker. The risk conferred by the polymorphism and the applicability in the general population must be clearly understood. Thus, the development and widespread application of a pharmacogenomic biomarker is an involved process and for most disease states we are just at the beginning of the journey towards individualized therapy and improved clinical outcome.

  12. Effect of a HIF-1 Alpha Polymorphism on the Incidence and Prostate Cancer

    Science.gov (United States)

    2007-02-01

    factor levels and risk of prostate cancer. Cancer Epidemiol Biomarkers Prev 2005;14(6):1557-1561. 34. Percy MJ, Mooney SM, McMullin MF, Flores A...vascular endothelial growth factor in pathological angiogenesis. Breast Cancer Research & Treatment 1995;36(2):127-137. 37. Jackson MW, Bentel JM, Tilley

  13. Vigilancia epidemiológica del dengue en Antioquia

    Directory of Open Access Journals (Sweden)

    Marta Cecilia Ospina Ospina

    2004-03-01

    Full Text Available

    Antecedentes: los primeros casos de dengue en Antioquia se reportaron en 1975 en el municipio de Puerto Berrío. Entre 1976 y 1977 se presentó una gran epidemia en el Magdalena Medio y en los años 1978-1979 se incrementó el número de casos en el departamento, afectando principalmente las regiones de Urabá, Bajo Cauca, Occidente y Magdalena Medio

    (1; desde entonces Antioquia es considerada como una zona de riesgo para la presentación de la enfermedad. En 1980 se constató la presencia del vector en la zona norte del Valle de Aburrá y en el municipio de Medellín, coincidiendo con la presentación de casos compatibles

    2. Programa de vigilancia epidemiológica epidemiológica: desde 1987 la Dirección Seccional de Salud de Antioquia (DSSA realiza el control de Enfermedades Trasmitidas por Vectores de manera regular en el departamento.

    La vigilancia epidemiológica del dengue en Antioquia está basada en cuatro elementos:

    • Clínico: síntomas y signos compatibles.

    • Entomológico: índices de infestación larvaria y de adultos del vector.

    • Serológico: determinación de anticuerpos IgM en suero del paciente.

    • Virológico: aislamiento viral y determinación del serotipo.

    Los municipios notifican a través del SIVIGILA, los casos sospechosos a la DSSA y env

  14. a fenómenos epidemiológicos

    Directory of Open Access Journals (Sweden)

    Carlos Arturo Castro Castro

    2005-01-01

    Full Text Available En este artículo se presentan avances del proyecto de investigación modelación y simulación computacional usando sistemas de información geográfica (SIG con dinámicas de sistemas aplicados a fenómenos epidemiológicos con el cual se han abordado los principales modelos matemáticos usados en epidemiología (susceptible- infectado-recuperado: SIR, susceptible-infectado-recuperado-susceptible: SIRS, susceptible-infectado-susceptible: SIS, para su integración, espacialización y simulación usando diferentes técnicas computacionales con el fin de modelar factores críticos en la propagación de epidemias. Para correr el modelo, se tomaron los datos de una epidemia de asma en el distrito de Manhattan de Nueva York, del tutotial de ARCGIS® versión 8.3.

  15. Selected Issues of Legislation with regard to Operating Pharmacies in the Slovak Republic / Vybrané problémy právnej úpravy prevádzkovania lekární v podmienkach Slovenskej republiky

    Directory of Open Access Journals (Sweden)

    Capandová Petra

    2015-06-01

    Full Text Available Medzi základné práva a slobody, upravené v druhej hlave Ústavy Slovenskej republiky patrí aj právo na ochranu zdravia, bezplatnú zdravotnú starostlivosť na základe zdravotného poistenia, právo na zdravotnícke pomôcky za zákonom stanovených podmienok. Tieto práva sú garantované v ustanovení Čl. 40 Ústavy Slovenskej republiky v rámci ekonomických, sociálnych a kultúrnych práv a vzťahujú sa na každú fyzickú osobu, t. j. na človeka. Keďže sú tieto práva považované za ľudské práva v zmysle medzinárodného práva, sú garantované aj v mnohostranných medzinárodných zmluvách, ktorých signatárom je aj Slovenská republika, ako napríklad Medzinárodný pakt o hospodárskych, sociálnych a kultúrnych právach. Právna úprava prevádzkovania lekární v Slovenskej republike zahŕňa široké spektrum otázok a je pomerne rozsiahla. Snahou zákonodarcu bolo nastaviť také pravidlá, ktoré by stransparentnili a zjednodušili právne prostredie v tomto sektore. V niektorých oblastiach sú pravidlá dané legislatívou Európskej únie a slovenský právny poriadok ich iba prevzal. Najdôležitejším prvokom v tejto sfére, ktorý nie je priamo upravovaný legislatívou EÚ, je poskytovanie lekárenskej starostlivosti a využívanie systému verejného zdravotného poistenia v tejto oblasti. Hlavným cieľom príspevku je poukázať na vybrané problémy, ktoré sa spájajú s postavením prevádzkovateľa lekárne a jeho povinnosťami, ktoré mu vyplývajú zo zákona o liekoch a s ktorými sa musí ako prevádzkovateľ lekárne vysporiadať. Táto oblasť podnikania je pomerne prísne regulovaná a preto je potrebné byť oboznámený s príslušnými právnymi predpismi. Príspevok z právno-teoretického hľadiska rieši viaceré otázky upravené v zákone o liekoch, či vyhláške o správnej lekárenskej praxi.

  16. Negocio fiduciario de inversión: único vehículo fiduciario que prevé protección para el fideicomitente y el fideicomisario, como inversionistas del mercado de valores

    Directory of Open Access Journals (Sweden)

    David Andrés Aguirre Soriano

    2013-07-01

    Full Text Available El objeto de este artículo es describir la fiducia de inversión como un vehículo fiduciario único dentro de los tipos de negocio fiduciario, debido a la presencia de algunos instrumentos de protección del inversionista que hacen aún más atractiva la fiducia de inversión, toda vez que por tratarse de una operación de intermediación en el mercado de valores, prevé instrumentos tales como la protección del fideicomitente y del fideicomisario, también llamado beneficiario, vía consumidor financiero tradicional de una sociedad de servicios financieros, y vía inversionista del mercado de valores; lo cual resulta muy atractivo para los futuros constituyentes, respecto de la protección que ofrece el ordenamiento jurídico en el resto de vehículos fiduciarios, tales como la fiducia de administración, inmobiliaria, etc., que se reducen solo al consumidor financiero.

  17. Negocio fiduciario de inversión: único vehículo fiduciario que prevé protección para el fideicomitente y el fideicomisario, como inversionistas del mercado de valores

    Directory of Open Access Journals (Sweden)

    David Andrés Aguirre Soriano

    2013-06-01

    Full Text Available El objeto de este artículo es describir la fiducia de inversión como un vehículo fiduciario único dentro de los tipos de negocio fiduciario, debido a la presencia de algunos instrumentos de protección del inversionista que hacen aún más atractiva la fiducia de inversión, toda vez que por tratarse de una operación de intermediación en el mercado de valores, prevé instrumentos tales como la protección del fideicomitente y del fideicomisario, también llamado beneficiario, vía consumidor financiero tradicional de una sociedad de servicios financieros, y vía inversionista del mercado de valores; lo cual resulta muy atractivo para los futuros constituyentes, respecto de la protección que ofrece el ordenamiento jurídico en el resto de vehículos fiduciarios, tales como la fiducia de administración, inmobiliaria, etc., que se reducen solo al consumidor financiero.

  18. Panorama epidemiológico de México, principales causas de morbilidad y mortalidad

    OpenAIRE

    Soto-Estrada, Guadalupe; Moreno-Altamirano, Laura; Pahua Díaz, Daniel

    2016-01-01

    Resumen Introducción: En este trabajo se presenta a grandes rasgos el panorama epidemiológico de México. A través de esta revisión se discute la mortalidad y morbilidad general por grupos específicos, los egresos hospitalarios y recursos humanos disponibles para la atención de la salud. Propósito: Analizar las transformaciones en el panorama epidemiológico actual del país en el marco de algunas variaciones demográficas y acordes al crecimiento económico y la evolución del salario mínimo. ...

  19. Aspectos epidemiológicos da peste no Brasil

    Directory of Open Access Journals (Sweden)

    João de Barros Barreto

    1946-09-01

    Full Text Available Mostram os A. A. que não são rigorosamente comparaveis os dados disponiveis sôbre a incidência da peste no Brasil, dentro de um período largo, uma vez que só ultimamente se vem conhecendo em vida um alto percentual dos casos da doença. Distribuindo por triênios os 2610 casos ocorridos no período 1934-1945, verifica-se o contraste do primeiro (1934-36 com os demais, tendo tocado àquele 47% do total. Coincide esse declínio geral com a ação do Govêrno Federal, que, em 1936, iniciou campanha coordenada contra a peste, intensificada com a criação, em 1941, do S. N. P. Restrita agora a doença ao chamado Nordeste brasileiro, continua Pernambuco sendo o seu principal foco, cabendo-lhe, desde 1934, 40 a 50% dos casos. Examinando os ocorridos no quinquênio 1941-1945, sôbre o qual há informes mais complexos, mostram os A. A. que mais de 50% desses casos se verificaram em pessoas com menos de 20 anos de idade, mais de 50% entre pardos e mais de 50% no sexo masculino. Afora 9 casos de peste pulmonar e 13 de forma septicêmica, os demais 724 foram de peste bubônica, 2/3 dos quais com localização inguino-crural. Em favor da benignidade da peste no nordeste, fala a letalidade, de 26% no quinquênio referido, e que se reduz, aliás, a 12% entre os doentes vistos em vida e medicados pelo Serviço. A letalidade é mais alta a partir dos 50 anos, maior entre as mulheres e entre pardos e negros. O emprêgo das sulfas, em substituição ao sôro, trouxe redução da letalidade. Estudando as técnicas de laboratório usadas para o diagnóstico da peste, graças ás quais se positivaram cêrca de 50% dos casos, examinam o valor da digitotomia em comparação com a viscerotomia e o da pesquisa do germe no suco ganglionar e no sangue. Respeito aos roedores domésticos com responsabilidade epidemiológica, aludem ao papel talvez atribuível ao Mus musculus. Comentam os achados de peste em roedores silvestres. Estudam os índices pulicidianos

  20. Combination of biomarkers

    DEFF Research Database (Denmark)

    Thurfjell, Lennart; Lötjönen, Jyrki; Lundqvist, Roger

    2012-01-01

    The New National Institute on Aging-Alzheimer's Association diagnostic guidelines for Alzheimer's disease (AD) incorporate biomarkers in the diagnostic criteria and suggest division of biomarkers into two categories: Aβ accumulation and neuronal degeneration or injury.......The New National Institute on Aging-Alzheimer's Association diagnostic guidelines for Alzheimer's disease (AD) incorporate biomarkers in the diagnostic criteria and suggest division of biomarkers into two categories: Aβ accumulation and neuronal degeneration or injury....

  1. A New Therapeutic Paradigm for Breast Cancer Exploiting Low Dose Estrogen-Induced Apoptosis

    Science.gov (United States)

    2012-06-01

    transcriptional repressor complex with RUNX3 [50], a known tumor suppressor that has been shown to be involved in apoptosis in gastric and colon cancer [51...A, et al. (2008) Apoptotic pathway induced by transduction of RUNX3 in the human gastric carcinoma cell line MKN-1. Cancer Sci 99: 23–30. 51. Tong DD...lung cancer risk in the cancer prevention study II nutrition cohort. Cancer Epidemiol Biomarkers Prev 2008;17:655-660. 115. Ramnath N, Menezes RJ

  2. Prognosis of Lung Cancer: Heredity or Environment

    Science.gov (United States)

    2015-06-01

    and white patients in an equal access health system. Cancer Epidemiol Biomarkers Prev 2012;21:1841–1847. 19. Hardy D, Xia R, Liu CC, Cormier JN...Nurgalieva Z, Du XL. Racial dis- parities and survival for nonsmall-cell lung cancer in a large cohort of black and white elderly patients. Cancer 2009;115...P. In lung cancer patients, age, race-ethnicity, gender and smoking predict adverse comor- bidity, which in turn predicts treatment and survival. J

  3. Impact of Contextual Factors on Prostate Cancer Risk and Outcomes

    Science.gov (United States)

    2014-04-01

    Description of measure Socioeconomic status US Census 2000 long form data (1) Block-level composite measure for income, education, poverty ...incidence patterns among California Hispanic women : Differences by nativity and residence in an enclave. Cancer Epidemiol Biomarkers Prev 2010; 19(5...Single, never married Married Separated or divorced Widowed Unknown 196 1274 170 82 78 10.9% 70.8% 9.4% 4.6% 4.3% Family history of

  4. The Infectious Pathogenesis Of Prostate Cancer

    Science.gov (United States)

    2011-04-01

    pyrimidine metabolism, and one-carbon folate , while pathways in the low-grade tumors were related to propanoate metabolism. Separating the cohorts...28. Brooks JD, et al.: CG island methylation changes near the GSTP1 gene in prostatic intraepithelial neoplasia. Cancer Epidemiol Biomarkers Prev 7(6...531-6, 1998. 29. Lee WH, et al.: CG island methylation changes near the GSTP1 gene in prostatic carcinoma cells detected using the polymerase chain

  5. Gene-Environment Interaction and Breast Cancer on Long Island, NY

    Science.gov (United States)

    2008-05-01

    Dietary flavonoid intake and breast cancer survival among women on Long Island. Cancer Epidemiol Biomarkers Prev. 2007 Nov;16(11):2285-92...Kuklenyik, Z., Needham, L.L., Calafat, A.M., 2005. Automated on-line column-switching HPLC -MS/MS method with peak focusing for the determination of...action. Environ Health Perspect 110:917–921. Rybak ME, Parker DL, Pfeiffer CM. 2006. Determination of Urinary Phytoestrogens by HPLC -MS/MS: A Comparison

  6. Bases epidemiológicas do Fator Acidentário Previdenciário Epidemiological foundations of the Accident Insurance Factor

    Directory of Open Access Journals (Sweden)

    Vilma Sousa Santana

    2005-12-01

    Full Text Available ANTECEDENTES: O Conselho Nacional de Previdência Social, por meio da Resolução No. 1.236 de 28/4/2004, aprovou uma nova metodologia para definição do valor das alíquotas de contribuição devidas por empresas para o financiamento de benefícios previdenciários relacionados aos riscos do trabalho. Esta metodologia baseia-se em um indicador denominado de Fator Acidentário Previdenciário, FAP, construído a partir do risco epidemiológico, estimado para cada ramo de atividade econômica. Como parte da sua estratégia de validação, o Ministério da Previdência Social decidiu pela avaliação da sua consistência epidemiológica. OBJETIVOS: Nesse estudo analisaram-se os propósitos, as fontes de informação, a natureza das medidas epidemiológicas empregadas e a metodologia da construção desse indicador, identificando-se as suas vantagens e limitações, aplicabilidade e impactos potenciais futuros. MÉTODOS: Análise documental da Resolução No. 1236 e do documento anexo. RESULTADOS: O FAP avança ao se pautar por critérios científicos transparentes que poderão permitir a redução das alíquotas quando houver efetiva melhoria das condições de trabalho, e conseqüentemente, da morbimortalidade entre trabalhadores. Supera as dificuldades relacionadas à definição e registro do nexo causal das doenças do trabalho ao considerá-las em sua totalidade, não se restringido às ocupacionais. Como prevê a redução de alíquotas com a melhoria das condições de saúde dos trabalhadores poderá contribuir para uma mais efetiva atuação dos empregadores na prevenção. CONCLUSÕES: É necessário o acompanhamento contínuo e sistemático da aplicação do FAP, com ampla participação da sociedade, revisando-o e ajustando-o aos diferentes cenários econômicos, sociais e de saúde do País, atentando-se para o seu impacto sobre a arrecadação e contas da Previdência Social.BACKGROUND: The Brazilian National Social Insurance

  7. Cardiac biomarkers in Neonatology

    OpenAIRE

    Vijlbrief, D.C.

    2015-01-01

    In this thesis, the role for cardiac biomarkers in neonatology was investigated. Several clinically relevant results were reported. In term and preterm infants, hypoxia and subsequent adaptation play an important role in cardiac biomarker elevation. The elevated natriuretic peptides are indicative of abnormal function; elevated troponins are suggestive for cardiomyocyte damage. This methodology makes these biomarkers of additional value in the treatment of newborn infants, separate or as a co...

  8. Estudio epidemiológico de salud oral en adultos. Comunidad Valenciana, 2006

    OpenAIRE

    Eustaquio Raga, Mª Vicenta

    2008-01-01

    RESUMEN En las últimas dos décadas se han venido realizando estudios epidemiológicos de salud oral en adultos en las diferentes comunidades autónomas españolas. Así la ausencia de dicho estudio de ámbito autonómico valenciano justifica plenamente su realización. En la realización del presente estudio nos hemos propuesto como objetivo general el evaluar el estado de salud bucodental de la población adulta y mayor de la Comunidad Valenciana. Se ha diseñado un estudio transversal o de p...

  9. Aspectos epidemiológicos del síndrome de Burnout en personal sanitario

    OpenAIRE

    Atance Martínez Juan Carlos

    1997-01-01

    FUNDAMENTOS: El Síndrome Burnout se invoca como probable responsable de la desmotivación que sufren los profesionales sanitarios actualmente. Esto sugiere la posibilidad de que este síndrome esté implicado en las elevadas tasas de absentismo laboral que presentan estos profesionales. El estudio pretende aportar una serie de caracterizaciones de las variables epidemiológicas universales que permitan una aproximación al perfil de riesgo en esta profesión. MÉTODO: Estudiamos una muestra de 294 p...

  10. Situación demográfica y epidemiológica de los adultos mayores. Santander. 1964 – 2011 / Demographic and Epidemiological Situation of Elderly People. Santander. 1964 – 2011 / Situação demográfica e epidemiológica das pessoas idosas. Santander. 1964 – 2011

    Directory of Open Access Journals (Sweden)

    Ana Luz Loaiza-Valencia, MSc.

    2015-07-01

    incapacitantes. Objetivo: Descrever a situação demográfica e epidemiológica das pessoas idosas no departamento de Santander, entre 1964 e 2020, e a informação sobre a morbidade do 2011. Metodologia: São usados os censos e as projeções da população e indicadores demográficos entre 1964 e 2020, mortes não-fetais por lugar de residência, e registros individuais de prestação de serviços de saúde -RIPS- de 2011. Foi realizada análise descritiva com base no sexo, idade, diagnóstico da consulta e causa básica da morte. Resultados: A população Santandereana mostra um aumento constante em seus números, mas a um ritmo mais lento do que nas décadas anteriores. As taxas de fertilidade e as de natalidade têm caído, prevê-se que a taxa de mortalidade vai começar a aumentar novamente, mas a expectativa de vida continua crescendo. Em 2015, haverá 251.136 pessoas com 60 anos ou mais, das quais 44% serão homens e 56% serão mulheres. (Em 2015, havia 251.136 pessoas com 60 anos ou mais, das quais 44% eram homens e 56% mulheres. Conclusões: As taxas de nascimento e de fertilidade projetam-se em declínio. Em contraste, a taxa bruta de mortalidade aumentou a partir de 2010 e sua projeção continua nesta direção, até sua estabilização. A expectativa de vida ao nascer é maior para mulheres do que para os homens, estes dados confirmam o fenômeno da feminização do envelhecimento. A situação da morbidade é geralmente aguda e crônica, com doenças não transmissíveis. [Loaiza Valencia AL. Situação demográfica e epidemiológica dos idosos. Santander. 1964 - 2011. MedUNAB 2015; 18 (1: 58-65].

  11. Características epidemiológicas da febre amarela no Brasil, 2000-2012

    Directory of Open Access Journals (Sweden)

    Karina Ribeiro Leite Jardim Cavalcante

    Full Text Available OBJETIVO: o estudo visa descrever as características epidemiológicas da febre amarela no Brasil no período de 2000 a 2012. MÉTODOS: estudo epidemiológico, ecológico, descritivo, utilizando informações dos bancos de dados do Ministério da Saúde. RESULTADOS: foram confirmados 326 casos de febre amarela no país nesse período, com 156 óbitos e taxa de letalidade média de 47,8%; o grupo de adultos jovens do sexo masculino foi o mais acometido; nas epizootias, foi identificado um total de 2.856 primatas não humanos notificados com suspeita de febre amarela, 31,1% deles confirmados laboratorialmente; no período estudado, foi identificada expansão da área de transmissão silvestre da doença para regiões densamente povoadas, como Sul, Sudeste e Centro-Oeste. CONCLUSÃO: persiste o risco de transmissão urbana da febre amarela, pois a incidência silvestre da doença tem se expandido para regiões onde existe alta infestação do Aedes aegypti, mosquito transmissor do ciclo urbano da doença.

  12. Biomarkers in Autism

    Directory of Open Access Journals (Sweden)

    Robert eHendren

    2014-08-01

    Full Text Available Autism spectrum disorders (ASD are complex, heterogeneous disorders caused by an interaction between genetic vulnerability and environmental factors. In an effort to better target the underlying roots of ASD for diagnosis and treatment, efforts to identify reliable biomarkers in genetics, neuroimaging, gene expression and measures of the body’s metabolism are growing. For this article, we review the published studies of potential biomarkers in autism and conclude that while there is increasing promise of finding biomarkers that can help us target treatment, there are none with enough evidence to support routine clinical use unless medical illness is suspected. Promising biomarkers include those for mitochondrial function, oxidative stress, and immune function. Genetic clusters are also suggesting the potential for useful biomarkers.

  13. Prognostic biomarkers in osteoarthritis

    Science.gov (United States)

    Attur, Mukundan; Krasnokutsky-Samuels, Svetlana; Samuels, Jonathan; Abramson, Steven B.

    2013-01-01

    Purpose of review Identification of patients at risk for incident disease or disease progression in osteoarthritis remains challenging, as radiography is an insensitive reflection of molecular changes that presage cartilage and bone abnormalities. Thus there is a widely appreciated need for biochemical and imaging biomarkers. We describe recent developments with such biomarkers to identify osteoarthritis patients who are at risk for disease progression. Recent findings The biochemical markers currently under evaluation include anabolic, catabolic, and inflammatory molecules representing diverse biological pathways. A few promising cartilage and bone degradation and synthesis biomarkers are in various stages of development, awaiting further validation in larger populations. A number of studies have shown elevated expression levels of inflammatory biomarkers, both locally (synovial fluid) and systemically (serum and plasma). These chemical biomarkers are under evaluation in combination with imaging biomarkers to predict early onset and the burden of disease. Summary Prognostic biomarkers may be used in clinical knee osteoarthritis to identify subgroups in whom the disease progresses at different rates. This could facilitate our understanding of the pathogenesis and allow us to differentiate phenotypes within a heterogeneous knee osteoarthritis population. Ultimately, such findings may help facilitate the development of disease-modifying osteoarthritis drugs (DMOADs). PMID:23169101

  14. Biomarkers in Airway Diseases

    Directory of Open Access Journals (Sweden)

    Janice M Leung

    2013-01-01

    Full Text Available The inherent limitations of spirometry and clinical history have prompted clinicians and scientists to search for surrogate markers of airway diseases. Although few biomarkers have been widely accepted into the clinical armamentarium, the authors explore three sources of biomarkers that have shown promise as indicators of disease severity and treatment response. In asthma, exhaled nitric oxide measurements can predict steroid responsiveness and sputum eosinophil counts have been used to titrate anti-inflammatory therapies. In chronic obstructive pulmonary disease, inflammatory plasma biomarkers, such as fibrinogen, club cell secretory protein-16 and surfactant protein D, can denote greater severity and predict the risk of exacerbations. While the multitude of disease phenotypes in respiratory medicine make biomarker development especially challenging, these three may soon play key roles in the diagnosis and management of airway diseases.

  15. amphibian_biomarker_data

    Data.gov (United States)

    U.S. Environmental Protection Agency — Amphibian metabolite data used in Snyder, M.N., Henderson, W.M., Glinski, D.G., Purucker, S. T., 2017. Biomarker analysis of american toad (Anaxyrus americanus) and...

  16. Validation of New Cancer Biomarkers

    DEFF Research Database (Denmark)

    Duffy, Michael J; Sturgeon, Catherine M; Söletormos, Georg

    2015-01-01

    BACKGROUND: Biomarkers are playing increasingly important roles in the detection and management of patients with cancer. Despite an enormous number of publications on cancer biomarkers, few of these biomarkers are in widespread clinical use. CONTENT: In this review, we discuss the key steps...... in advancing a newly discovered cancer candidate biomarker from pilot studies to clinical application. Four main steps are necessary for a biomarker to reach the clinic: analytical validation of the biomarker assay, clinical validation of the biomarker test, demonstration of clinical value from performance...... of the biomarker test, and regulatory approval. In addition to these 4 steps, all biomarker studies should be reported in a detailed and transparent manner, using previously published checklists and guidelines. Finally, all biomarker studies relating to demonstration of clinical value should be registered before...

  17. Cenário epidemiológico de morbidade no ambiente de trabalho no Brasil

    OpenAIRE

    Graup, Susane

    2012-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia de Produção, Florianópolis, 2012 As doenças do trabalho tem se tornado um problema de saúde pública, devido ao seu impacto socioeconômico, gerado a partir de prevalências que tem tomado proporções epidêmicas em todo o mundo. Diante dessas informações, o objetivo deste estudo foi estabelecer o cenário de ocorrência epidemiológica de morbidades no ambiente de trabalho no Bra...

  18. Contribución al estudio epidemiológico del kala-azar en Colombia

    Directory of Open Access Journals (Sweden)

    Augusto Corredor Arjona

    1971-01-01

    Full Text Available Los autores informan sobre el estudio epidemiológico del kala-azar en un foco situado en el municipio de Melgar, departamento del Tolima. Colombia. Encontraron la modalidad del kala-azar de la zona neotropical descrita en otras partes de América; mayor incidencia en los grupos humanos menores de cinco años, perros frecuentemente infectados, presencia de lutzomyia longipalpis. Hacen una discursión sobre la aparición de nuevos focos de kala-azar relacionándolos con la suspensión del rociado de D.D.T. hecho por la campaña de erradicación de la malaria y suponen la aparición de nuevos casos de kala-azar en zonas ecológicas similares.

  19. Biomarkers of sepsis

    Science.gov (United States)

    2013-01-01

    Sepsis is an unusual systemic reaction to what is sometimes an otherwise ordinary infection, and it probably represents a pattern of response by the immune system to injury. A hyper-inflammatory response is followed by an immunosuppressive phase during which multiple organ dysfunction is present and the patient is susceptible to nosocomial infection. Biomarkers to diagnose sepsis may allow early intervention which, although primarily supportive, can reduce the risk of death. Although lactate is currently the most commonly used biomarker to identify sepsis, other biomarkers may help to enhance lactate’s effectiveness; these include markers of the hyper-inflammatory phase of sepsis, such as pro-inflammatory cytokines and chemokines; proteins such as C-reactive protein and procalcitonin which are synthesized in response to infection and inflammation; and markers of neutrophil and monocyte activation. Recently, markers of the immunosuppressive phase of sepsis, such as anti-inflammatory cytokines, and alterations of the cell surface markers of monocytes and lymphocytes have been examined. Combinations of pro- and anti-inflammatory biomarkers in a multi-marker panel may help identify patients who are developing severe sepsis before organ dysfunction has advanced too far. Combined with innovative approaches to treatment that target the immunosuppressive phase, these biomarkers may help to reduce the mortality rate associated with severe sepsis which, despite advances in supportive measures, remains high. PMID:23480440

  20. Mass spectrometry for biomarker development

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Chaochao; Liu, Tao; Baker, Erin Shammel; Rodland, Karin D.; Smith, Richard D.

    2015-06-19

    Biomarkers potentially play a crucial role in early disease diagnosis, prognosis and targeted therapy. In the past decade, mass spectrometry based proteomics has become increasingly important in biomarker development due to large advances in technology and associated methods. This chapter mainly focuses on the application of broad (e.g. shotgun) proteomics in biomarker discovery and the utility of targeted proteomics in biomarker verification and validation. A range of mass spectrometry methodologies are discussed emphasizing their efficacy in the different stages in biomarker development, with a particular emphasis on blood biomarker development.

  1. Biomarkers of the Dementia

    Directory of Open Access Journals (Sweden)

    Mikio Shoji

    2011-01-01

    Full Text Available Recent advances in biomarker studies on dementia are summarized here. CSF Aβ40, Aβ42, total tau, and phosphorylated tau are the most sensitive biomarkers for diagnosis of Alzheimer's disease (AD and prediction of onset of AD from mild cognitive impairment (MCI. Based on this progress, new diagnostic criteria for AD, MCI, and preclinical AD were proposed by National Institute of Aging (NIA and Alzheimer's Association in August 2010. In these new criteria, progress in biomarker identification and amyloid imaging studies in the past 10 years have added critical information. Huge contributions of basic and clinical studies have established clinical evidence supporting these markers. Based on this progress, essential therapy for cure of AD is urgently expected.

  2. Inflammatory biomarkers and cancer

    DEFF Research Database (Denmark)

    Rasmussen, Line Jee Hartmann; Schultz, Martin; Gaardsting, Anne

    2017-01-01

    and previous cancer diagnoses compared to patients who were not diagnosed with cancer. Previous cancer, C-reactive protein (CRP) and suPAR were significantly associated with newly diagnosed cancer during follow-up in multiple logistic regression analyses adjusted for age, sex and CRP. Neither any of the PRRs......In Denmark, patients with serious nonspecific symptoms and signs of cancer (NSSC) are referred to the diagnostic outpatient clinics (DOCs) where an accelerated cancer diagnostic program is initiated. Various immunological and inflammatory biomarkers have been associated with cancer, including...... soluble urokinase plasminogen activator receptor (suPAR) and the pattern recognition receptors (PRRs) pentraxin-3, mannose-binding lectin, ficolin-1, ficolin-2 and ficolin-3. We aimed to evaluate these biomarkers and compare their diagnostic ability to classical biomarkers for diagnosing cancer...

  3. La transición demográfico-epidemiológica en Chile, 1960-2001

    OpenAIRE

    Szot Meza Jorge

    2003-01-01

    Fundamento: En Chile se ha modificado de manera significativa la estructura demográfica y las causas de morbilidad y de mortalidad de la población en un período relativamente breve de tiempo. Estas variaciones se enmarcan dentro de los procesos denominados transición demográfica y transición epidemiológica respectivamente. El propósito de este trabajo es evidenciar la transición demográfica y la transición epidemiológica ocurridas en el país entre 1960 y 2001. Método: Se trata de un estudio d...

  4. Aspectos epidemiológicos del síndrome de Burnout en personal sanitario

    Directory of Open Access Journals (Sweden)

    Atance Martínez Juan Carlos

    1997-01-01

    Full Text Available FUNDAMENTOS: El Síndrome Burnout se invoca como probable responsable de la desmotivación que sufren los profesionales sanitarios actualmente. Esto sugiere la posibilidad de que este síndrome esté implicado en las elevadas tasas de absentismo laboral que presentan estos profesionales. El estudio pretende aportar una serie de caracterizaciones de las variables epidemiológicas universales que permitan una aproximación al perfil de riesgo en esta profesión. MÉTODO: Estudiamos una muestra de 294 profesionales de atención primaria y atención especializada aleatoriamente. a los que se les aplicó el instrumento de medida del Síndrome de Burnout (Maslach Burnout Inventory de forma autoadministrada. Se hizo estadística descriptiva con comparación de medias para variables sociodemográficas (P< 0,05 con Epiinfo V.60 y SPSS PC.W. RESULTADOS: Obtuvimos 87,76% de respuestas frente al 12,23% de pérdidas. Esta muestra nos permite una confianza del 95% y un error del 5%. Obtuvimos diferencias significativas en función del sexo, edad, estado civil, antigüedad en la profesión en el centro de trabajo, número de trabajadores en el centro, lugar de trabajo, número de enfermos a cargo, horas de trabajo semanales, tiempo de interacción con los pacientes. La media de presencia del síndrome de Burnout fue 47,16 + 7.93, siendo las mayores proporciones las consignadas para las dimensiones cansancio emocional y falta de realización. CONCLUSIONES: El perfil epidemiológico de riesgo obtenido sería: mujer de más de 44 años sin pareja estable, con más de 19 años de antigüedad en la profesión y más de 11 en el centro, profesional de atención especializada, con más de 21 pacientes diarios a su cargo, a los que dedica más del 70% de la jornada laboral y a ésta entre 36 y 40 horas semanales.

  5. Perfil epidemiológico de la hepatitis B y D en Colombia

    Directory of Open Access Journals (Sweden)

    Carlos A. Espinal

    1998-09-01

    Full Text Available Colombia presenta una gran diversidad epidemiológica en las prevalencias de infección y portadores del virus B (VHB, de acuerdo con las regiones geográficas y sus grupos de población. El virus delta (VHD se encuentra ampliamente distribuido, asociado con epidemias de hepatitis fulminante en áreas de elevada prevalencia del VHB. Los resultados de los estudios realizados por instituciones y servicios de salud en grupos de población por regiones y departamentos, comunidades indígenas y trabajadores de salud, han permitido la configuración del mapa de riesgo para los virus B y D, de acuerdo con los patrones de alta y mediana endemicidad de ambas infecciones en la población. Las elevadas proporciones de infección informadas en comunidades, bancos de sangre y personal de salud, demuestran que Colombia es un país de alto riesgo para el VHB y VHD, con niveles intermedios en algunos departamentos. Las elevadas prevalencias en poblaciones indígenas requieren de un programa intensificado de control mediante la vacunación. Las coberturas de vacunación en la comunidad y en el personal de salud deben incrementarse con el fin de reducir la población susceptible y el riesgo de infección. Colombia presenta tasas de riesgo intermedio para el hepatocarcinoma primario. Estudios en la ciudad de Cali confirman la asociación epidemiológica entre hepatocarcinoma, cirrosis y la prevalencia por comunas del VHB. Estos factores ameritan la intensificación de la vacunación universal de la infancia y el inicio de programas de vacunación en los adolescentes. Adicionalmente, debe incrementarse la vacunación de los adultos a través de las diferentes entidades que desarrollan programas de prevención y promoción de la salud.

  6. Biomarkers for anorexia nervosa

    DEFF Research Database (Denmark)

    Sjøgren, Jan Magnus

    2017-01-01

    Biomarkers for anorexia nervosa (AN) which reflect the pathophysiology and relate to the aetiology of the disease, are warranted and could bring us one step closer to targeted treatment of AN. Some leads may be found in the biochemistry which often is found disturbed in AN, although normalization...

  7. Biomarkers of cancer cachexia.

    Science.gov (United States)

    Loumaye, Audrey; Thissen, Jean-Paul

    2017-12-01

    Cachexia is a complex multifactorial syndrome, characterized by loss of skeletal muscle and fat mass, which affects the majority of advanced cancer patients and is associated with poor prognosis. Interestingly, reversing muscle loss in animal models of cancer cachexia leads to prolong survival. Therefore, detecting cachexia and maintaining muscle mass represent a major goal in the care of cancer patients. However, early diagnosis of cancer cachexia is currently limited for several reasons. Indeed, cachexia development is variable according to tumor and host characteristics. In addition, safe, accessible and non-invasive tools to detect skeletal muscle atrophy are desperately lacking in clinical practice. Finally, the precise molecular mechanisms and the key players involved in cancer cachexia remain poorly characterized. The need for an early diagnosis of cancer cachexia supports therefore the quest for a biomarker that might reflect skeletal muscle atrophy process. Current research offers different promising ways to identify such a biomarker. Initially, the quest for a biomarker of cancer cachexia has mostly focused on mediators of muscle atrophy, produced by both tumor and host, in an attempt to define new therapeutic approaches. In another hand, molecules released by the muscle into the circulation during the atrophy process have been also considered as potential biomarkers. More recently, several "omics" studies are emerging to identify new muscular or circulating markers of cancer cachexia. Some genetic markers could also contribute to identify patients more susceptible to develop cachexia. This article reviews our current knowledge regarding potential biomarkers of cancer cachexia. Copyright © 2017 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  8. Cambios epidemiológicos en una unidad de Gineco- Obstetricia de un hospital chileno

    Directory of Open Access Journals (Sweden)

    Pablo Pérez C.

    2010-01-01

    Full Text Available Objetivo, Describir los cambios en el número de nacimientos, tasa de parto normal (TPN, fórceps (TPF, cesárea (TPC, tasa de embarazo múltiple (TEM y embarazo ectópico (TEE. Diseño, Estudio descriptivo y retrospectivo Lugar, Hospital Naval - Chile. Participantes, 9627 fichas clínicas entre 200-2010. Intervenciones, Formato de registro. Principales medidas de resultados, Frecuencias relativas y absolutas. Resultados, El número de nacimientos se ha reducido en un36,7%. Se vio una disminución de la TPN de un 57.8% a 53.8%, un aumento de la TPC de 32.35% a 42.4%. y una disminución de la TPF de 9.85% a 3,8%, la TEM aumentó de 0.81% a 3.2%, y la TEE de 1,45% a 1,71%. Conclusiones, Se observaron importantes cambios epidemiológicos durante los últimos diez años. Es relevante la evaluación de estos parámetros para establecer causalidades y repercusiones clínicas.

  9. La transición epidemiológica de las y los adolescentes en México

    Directory of Open Access Journals (Sweden)

    Santos-Preciado José Ignacio

    2003-01-01

    Full Text Available OBJETIVO: Identificar los niveles de salud de la adolescencia en México en su demografía, contexto social y económico. MATERIAL Y MÉTODOS: Se efectuó una revisión de la literatura y de estadísticas vitales, así como de encuestas de opinión, con la finalidad de evaluar el impacto de la transición epidemiológica frente a la disponibilidad y prioridades de los servicios de salud para adolescentes. El modelo epidemiológico de Omran se utilizó para clasificar las características demográficas, sociales y económicas de adolescentes mexicanos como un esfuerzo para definir su impacto en la transición epidemiológica de este grupo de edad. RESULTADOS: Los datos demográficos se presentan en una perspectiva de la transición epidemiológica, la cual nos permite realizar inferencias de las condiciones sociales, patrones de desarrollo y de necesidades en salud de este grupo poblacional en México. Los datos se presentan atendiendo a la demanda y disponibilidad de servicios de salud, el impacto de la educación, las oportunidades de empleo, el rol en la familia y el bienestar. Otros aspectos importantes presentados incluyen la educación sexual y la salud reproductiva, y los relacionados con el SIDA/VIH como pandemia en este grupo de edad. CONCLUSIONES: Los hallazgos presentados revelan que la secuencia tradicional de variables, en la explicación de la transición epidemiológica, no puede seguir manejándose como hasta ahora y nos sugieren de manera imperativa la necesidad de perfilar las necesidades de salud de la adolescencia desde un enfoque holístico, con énfasis en la promoción de estilos de vida sana, que favorezcan un desarrollo justo y equitativo y que además ayuden a enfocar la respuesta social organizada.

  10. Biomarkers of Pediatric Brain Tumors

    Directory of Open Access Journals (Sweden)

    Mark D Russell

    2013-03-01

    Full Text Available Background and Need for Novel Biomarkers: Brain tumors are the leading cause of death by solid tumors in children. Although improvements have been made in their radiological detection and treatment, our capacity to promptly diagnose pediatric brain tumors in their early stages remains limited. This contrasts several other cancers where serum biomarkers such as CA 19-9 and CA 125 facilitate early diagnosis and treatment. Aim: The aim of this article is to review the latest literature and highlight biomarkers which may be of clinical use in the common types of primary pediatric brain tumor. Methods: A PubMed search was performed to identify studies reporting biomarkers in the bodily fluids of pediatric patients with brain tumors. Details regarding the sample type (serum, cerebrospinal fluid or urine, biomarkers analyzed, methodology, tumor type and statistical significance were recorded. Results: A total of 12 manuscripts reporting 19 biomarkers in 367 patients vs. 397 controls were identified in the literature. Of the 19 biomarkers identified, 12 were isolated from cerebrospinal fluid, 2 from serum, 3 from urine, and 2 from multiple bodily fluids. All but one study reported statistically significant differences in biomarker expression between patient and control groups.Conclusions: This review identifies a panel of novel biomarkers for pediatric brain tumors. It provides a platform for the further studies necessary to validate these biomarkers and, in addition, highlights several techniques through which new biomarkers can be discovered.

  11. Novel biomarkers for sepsis

    DEFF Research Database (Denmark)

    Larsen, Frederik Fruergaard; Petersen, J Asger

    2017-01-01

    BACKGROUND: Sepsis is a prevalent condition among hospitalized patients that carries a high risk of morbidity and mortality. Rapid recognition of sepsis as the cause of deterioration is desirable, so effective treatment can be initiated rapidly. Traditionally, diagnosis was based on presence of two...... or more positive SIRS criteria due to infection. However, recently published sepsis-3 criteria put more emphasis on organ dysfunction caused by infection in the definition of sepsis. Regardless of this, no gold standard for diagnosis exist, and clinicians still rely on a number of traditional and novel...... biomarkers to discriminate between patients with and without infection, as the cause of deterioration. METHOD: Narrative review of current literature. RESULTS: A number of the most promising biomarkers for diagnoses and prognostication of sepsis are presented. CONCLUSION: Procalcitonin, presepsin, CD64, su...

  12. [Biomarkers of Alzheimer disease].

    Science.gov (United States)

    Rachel, Wojciech; Grela, Agatha; Zyss, Tomasz; Zieba, Andrzej; Piekoszewski, Wojciech

    2014-01-01

    Cognitive impairment is one of the most abundant age-related psychiatric disorders. The outcome of cognitive impairment in Alzheimer's disease has both individual (the patients and their families) and socio-economic effects. The prevalence of Alzheimer's disease doubles after the age of 65 years, every 4.5 years. An etiologically heterogenic group of disorders related to aging as well as genetic and environmental interactions probably underlie the impairment in Alzheimer's disease. Those factors cause the degeneration of brain tissue which leads to significant cognitive dysfunction. There are two main hypotheses that are linked to the process of neurodegeneration: (i) amyloid cascade and (ii) the role of secretases and dysfunction of mitochondria. From the therapeutic standpoint it is crucial to get an early diagnosis and start with an adequate treatment. The undeniable progress in the field of biomarker research should lead to a better understanding of the early stages of the disorder. So far, the best recognised and described biomarkers of Alzheimer's disease, which can be detected in both cerebrospinal fluid and blood, are: beta-amyloid, tau-protein and phosphorylated tau-protein (phospho-tau). The article discusses the usefulness of the known biomarkers of Alzheimer's disease in early diagnosis.

  13. Ingestão alimentar em estudos epidemiológicos Food intake in epidemiological studies

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    Aline Cristine Souza Lopes

    2003-09-01

    Full Text Available A epidemiologia da nutrição dispõe de uma gama de metodologias para avaliar o estado nutricional. Entretanto, os métodos dietéticos são os únicos capazes de detectar a deficiência nutricional em seu estágio inicial, sendo por isso bastante utilizados em estudos epidemiológicos de associação entre exposições e eventos. Atualmente, o método dietético mais indicado para estudos epidemiológicos, principalmente aqueles envolvendo doenças crônico-degenerativas, tem sido o questionário semiquantitativo de freqüência alimentar (QSFA. Este instrumento, não diferente de outros, está sujeito à variabilidade e a erros de medida. Entretanto, estes podem ser identificados e tratados utilizando-se métodos como comparação de médias dietéticas, estudos de confiabilidade, de validação relativa e de calibração. Em estudo realizado em Bambuí-MG, o consumo de nutrientes foi avaliado por três diferentes métodos: QSFA e recordatórios 24 horas (R24 com e sem réplicas de alimentos, tendo suas médias comparadas e calibradas. As médias encontradas pelo QSFA foram consistentemente maiores do que as dos R24. No entanto, quando essas foram ajustadas pelo consumo calórico total não apresentaram diferenças importantes, exceto para fibras; zinco; vitaminas C; B6, e E; e colesterol. E as médias calibradas foram, em geral, menores do que as não calibradas, sendo estatisticamente significantes para ingestão de lipídeos; fibras; zinco; vitaminas C, E e A; ácidos graxos saturados, monoinsaturados e poliinsaturados; e colesterol.There are several approaches aiming to evaluate nutritional status available for epidemiological studies. Dietary methods are some of the most recommended because of their ability to detect nutritional deficiency in its initial stage. Currently, the Semiquantitative Food Frequency Questionnaire (SFFQ has been chosen as the best dietary method, especially when dealing with chronic degenerative diseases. This

  14. Febre amarela. I - Aspectos cíclicos e epidemiológicos

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    M. R. Q. de Kastner

    1976-02-01

    Full Text Available Relata-se um resumo epidemiológico do surto epizoótico de febre amarela ocorrido no ano de 1973. São postas em evidência a sua incidência, a distribuição por idades, a distribuição por sexo e a distribuição geográfica. Em seguida, são apresentados os resultados obtidos pela revisão dos casos de febre amarela, que vêm sendo estudados, recolhidos e arquivados na Coleção do Serviço de Viscerotomia da Seção de Histopatologia da Febre Amarela do Instituto Oswaldo Cruz, desde 1931. O trabalho está documentado com tabelas e gráficos que registram os dados acima indicados. Os autores ressaltam os seguintes pontos: 1 A Febre amarela, urbana e silvestre, apresenta quadros epidemiológicos inteiramente diferentes; 2 A incidência da febre amarela silvestre ocorre principalmente no sexo masculino, de acordo com os dados estatisticamente significativos; 3 A idade mais atingida pela forma silvestre é a entre 20 e 30 anos; 4 A febre amarela silvestre continua em áreas enzoóticas, ao longo dos cursos d'água; 5 Parece existir uma relação entre as condições climáticas e a incidência da febre amarela; 6 Os surtos de febre amarela ocorrem aproximadamente de 7 em 7 anos; 7 É do máximo valor o programa de vacinação e o serviço de viscerotomia da SUCAM.It is presented an epidemiological summary of epizootic yellow fever outbreak happened in 1973. Its incidence, the distribution according to ages, to sex and geographical distribuion are pointed out. The results of the revision of yellow fever cases, which have been studied, collected and archived in viscerotomy Service collection of Histopathology of Yellow section of Oswaldo Cruz Institute, since 1931 are presented. The article is ilustrated with tables and graphics which registrate the data indicated above. The authors emphasize the following items: 1 Urban and jungle yellow fever present epidemiological aspects completely different; 2 Jungle yellow fever incidence occurs mainly

  15. Situación epidemiológica de la obesidad en Argentina

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    Mariana Galante

    2016-04-01

    Full Text Available Introducción: La obesidad puede entenderse como el resultado de personas respondiendo normalmente al contexto obesogénico en el que se encuentran inmersas. Objetivo: describir la situación epidemiológica de la obesidad y sobrepeso en adultos y adolescentes en Argentina. Métodos: Se estimó la prevalencia de obesidad y sobrepeso y factores asociados en adultos y estudiantes de 13 a 15 años a partir de datos de la Encuesta Nacional de Factores de Riesgo de enfermedades no transmisibles (ENFR y de la Encuesta Mundial de Salud Escolar. Resultados: En 2013, la prevalencia de sobrepeso (37,1% y obesidad (20,8% fue mayor a la observada en ediciones previas de la ENFR. Ambos indicadores fueron más frecuentes entre varones y en personas de mayor edad. El nivel educativo y de ingresos se asoció en forma independiente con una mayor prevalencia de obesidad en mujeres. En adolescentes, en el año 2012, la prevalencia de sobrepeso fue de 22,8% y la de obesidad de 5,9%. Esta última fue mayor en estudiantes con madres con primario incompleto (8,9% vs. 4,6% en hijos de madres con secundario completo, p=0,002. Conclusiones: Acciones multisectoriales de gran escala son necesarias para frenar la tendencia en aumento de la epidemia de obesidad. Aunque la evidencia es aún escasa, varias estrategias poblacionales han sido propuestas: campañas de comunicación y educación, regulación del precio de alimentos mediante subsidios o impuestos, etiquetado y advertencias sanitarias, regulación de la publicidad dirigida a niños y adolescentes, mejoras en el entorno alimentario escolar y laboral, reformulación de productos ultraprocesados, entre otros.

  16. Leishmaniasis tegumentaria americana: encuesta epidemiológica en una comunidad indígena

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    Martha Wolff

    1988-01-01

    Full Text Available Se realizó un estudio epidemiológico sobre Leishmaniasis tegumentarla americana (LTA en 809 personas del Resguardo Indígena de San Andrés de Sotavento, Departamento de Córdoba, foco endémico tanto de Leishmaniasis cutánea como de Leishmaniasis visceral. La distribución por sexo de la población encuestada fue de 355 (43,9% hombres y 454 (56, 1% mujeres; sus índices alérgicos fueron de 36,9% y 40,5% respectivamente. La positividad de la Intradermorreacción de Montenegro ascendió en personas de ambos sexos, a medida que aumentó la edad. El índice parasitario fue de 0.37%. La especie de Lutzomyia más frecuente en el intra y peridomicilio fue la Lu. evansi que mostró comportamiento antropofílico. Se encontró una alta exposición de la población general al vector dada la facilidad de penetración de los flebotomineos alintradomicilio, por el tipo de construcción de las viviendas; además, al no existir servicios sanitarios, acueductos ni alcantarillados Intradomiciliarios, todo el núcleo familiar debe desplazarse al peridomicilio para la disposición de excretas y en busca del agua. Otros hallazgos fueron el gran desconocimiento sobre la etiología y tratamiento de la Leishmaniasis y las pésimas condiciones sociales y económicas de la región.

  17. Cáncer de mama, su caracterización epidemiológica

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    Yisel de la Caridad Ramos Águila

    2015-08-01

    Full Text Available Introducción: el cáncer de mama constituye un problema de salud, ocupando la segunda causa de muerte por cáncer en mujeres. Objetivo: describir los aspectos epidemiológicos del cáncer de mama en las mujeres del municipio Pinar del Río en el período 2012-2013. Material y método: se realizó una investigación observacional, descriptiva. El universo de estudio lo constituyeron todas las mujeres del municipio Pinar del Río con diagnóstico clínico y anátomo-patológico de cáncer de mama (N=135, atendidas en el hospital oncológico de la provincia en los años 2012 y 2013. Para la obtención de la información se aplicó una encuesta cuyas variables principales recogían datos demográficos (edad, antecedentes personales de lesiones benignas y malignas y familiares de cáncer de mama, elementos relacionados con el estado nutricional, los estilos de vida de las pacientes, así como sus características endocrino-reproductivas. El procesamiento estadístico de los datos se realizó utilizando medidas de resumen para variables cualitativas (frecuencias absolutas y porcentajes y para variables cuantitativas (promedio. Resultados: predominó la enfermedad entre los 50 y 69 años de edad. Los factores de riesgo más frecuentes fueron menarquía precoz, no ofrecimiento o menos de 4 meses de lactancia materna y uso de anticonceptivos hormonales. Conclusión: en las mujeres estudiadas se identificó, al menos, un factor de riesgo conocido para desarrollar cáncer de mama, aunque la no existencia de estos no excluye la posibilidad de padecerlo.

  18. Injuria renal aguda, perfil epidemiológico intrahospitalario y factores asociados al riesgo de muerte

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    Cristian León

    2014-10-01

    Full Text Available La injuria renal aguda (IRA es un evento mórbido de gran impacto en la vida de las personas. La tasa de letalidad de la IRA ha sido un tema relevante y se han estudiado muchos factores relacionados. Objetivos: Determinar el perfil epidemiológico de los pacientes con IRA en un hospital de Lima y los factores asociados a la mortalidad durante el periodo de hospitalización. Material y métodos: Estudio descriptivo, retrospectivo de una cohorte de pacientes incidentes con diagnóstico de IRA. Se calculó la letalidad bruta y la ajustada a tiempo de permanencia hospitalaria. Se usó la regresión multivariante de Cox, así como el mejor modelo para regresión logística binaria asociada a letalidad. Se aceptó una significancia estadística de p<0,05. Resultados: Se identificaron 90 pacientes con IRA en los años 2002, 2003 y 2004 (incidencia de 30, 39 y 21 pacientes/año, respectivamente. Su permanencia hospitalaria fue 13,44 ± 1,66 (promedio±1ES días, la tasa bruta de letalidad 39% y la tasa ajustada 2,89 fallecidos/100 días de hospitalización. Las variables relacionadas al riesgo de muerte en el tiempo fueron el estado de shock, el diagnóstico de sepsis y la disfunción respiratoria al momento de la admisión. Conclusiones: La gravedad clínica como condición al momento de la admisión al centro hospitalario, el estado séptico y la presencia de disfunción respiratoria, fueron los factores que influenciaron en el pronóstico de supervivencia de pacientes con IRA.

  19. Biomarkers in Diabetic Retinopathy

    Science.gov (United States)

    Jenkins, Alicia J.; Joglekar, Mugdha V.; Hardikar, Anandwardhan A.; Keech, Anthony C.; O'Neal, David N.; Januszewski, Andrzej S.

    2015-01-01

    There is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which is not related to adiposity. Whilst improved diabetes care has substantially improved diabetes outcomes, the disease remains a common cause of working age adult-onset blindness. Diabetic retinopathy is the most frequently occurring complication of diabetes; it is greatly feared by many diabetes patients. There are multiple risk factors and markers for the onset and progression of diabetic retinopathy, yet residual risk remains. Screening for diabetic retinopathy is recommended to facilitate early detection and treatment. Common biomarkers of diabetic retinopathy and its risk in clinical practice today relate to the visualization of the retinal vasculature and measures of glycemia, lipids, blood pressure, body weight, smoking, and pregnancy status. Greater knowledge of novel biomarkers and mediators of diabetic retinopathy, such as those related to inflammation and angiogenesis, has contributed to the development of additional therapeutics, in particular for late-stage retinopathy, including intra-ocular corticosteroids and intravitreal vascular endothelial growth factor inhibitors ('anti-VEGFs') agents. Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics. Therefore, more effective treatments for diabetic retinopathy are necessary. New analytical techniques, in particular those related to molecular markers, are accelerating progress in diabetic retinopathy research. Given the increasing incidence and prevalence of diabetes, and the limited capacity of healthcare systems to screen and treat

  20. Biomarkers in Diabetic Retinopathy.

    Science.gov (United States)

    Jenkins, Alicia J; Joglekar, Mugdha V; Hardikar, Anandwardhan A; Keech, Anthony C; O'Neal, David N; Januszewski, Andrzej S

    2015-01-01

    There is a global diabetes epidemic correlating with an increase in obesity. This coincidence may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained increase in the incidence of type 1 diabetes, which is not related to adiposity. Whilst improved diabetes care has substantially improved diabetes outcomes, the disease remains a common cause of working age adult-onset blindness. Diabetic retinopathy is the most frequently occurring complication of diabetes; it is greatly feared by many diabetes patients. There are multiple risk factors and markers for the onset and progression of diabetic retinopathy, yet residual risk remains. Screening for diabetic retinopathy is recommended to facilitate early detection and treatment. Common biomarkers of diabetic retinopathy and its risk in clinical practice today relate to the visualization of the retinal vasculature and measures of glycemia, lipids, blood pressure, body weight, smoking, and pregnancy status. Greater knowledge of novel biomarkers and mediators of diabetic retinopathy, such as those related to inflammation and angiogenesis, has contributed to the development of additional therapeutics, in particular for late-stage retinopathy, including intra-ocular corticosteroids and intravitreal vascular endothelial growth factor inhibitors ('anti-VEGFs') agents. Unfortunately, in spite of a range of treatments (including laser photocoagulation, intraocular steroids, and anti-VEGF agents, and more recently oral fenofibrate, a PPAR-alpha agonist lipid-lowering drug), many patients with diabetic retinopathy do not respond well to current therapeutics. Therefore, more effective treatments for diabetic retinopathy are necessary. New analytical techniques, in particular those related to molecular markers, are accelerating progress in diabetic retinopathy research. Given the increasing incidence and prevalence of diabetes, and the limited capacity of healthcare systems to screen and treat

  1. Predictive Biomarkers for Asthma Therapy.

    Science.gov (United States)

    Medrek, Sarah K; Parulekar, Amit D; Hanania, Nicola A

    2017-09-19

    Asthma is a heterogeneous disease characterized by multiple phenotypes. Treatment of patients with severe disease can be challenging. Predictive biomarkers are measurable characteristics that reflect the underlying pathophysiology of asthma and can identify patients that are likely to respond to a given therapy. This review discusses current knowledge regarding predictive biomarkers in asthma. Recent trials evaluating biologic therapies targeting IgE, IL-5, IL-13, and IL-4 have utilized predictive biomarkers to identify patients who might benefit from treatment. Other work has suggested that using composite biomarkers may offer enhanced predictive capabilities in tailoring asthma therapy. Multiple biomarkers including sputum eosinophil count, blood eosinophil count, fractional concentration of nitric oxide in exhaled breath (FeNO), and serum periostin have been used to identify which patients will respond to targeted asthma medications. Further work is needed to integrate predictive biomarkers into clinical practice.

  2. Biomarkers in Prostate Cancer Epidemiology

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    Mudit Verma

    2011-09-01

    Full Text Available Understanding the etiology of a disease such as prostate cancer may help in identifying populations at high risk, timely intervention of the disease, and proper treatment. Biomarkers, along with exposure history and clinical data, are useful tools to achieve these goals. Individual risk and population incidence of prostate cancer result from the intervention of genetic susceptibility and exposure. Biochemical, epigenetic, genetic, and imaging biomarkers are used to identify people at high risk for developing prostate cancer. In cancer epidemiology, epigenetic biomarkers offer advantages over other types of biomarkers because they are expressed against a person’s genetic background and environmental exposure, and because abnormal events occur early in cancer development, which includes several epigenetic alterations in cancer cells. This article describes different biomarkers that have potential use in studying the epidemiology of prostate cancer. We also discuss the characteristics of an ideal biomarker for prostate cancer, and technologies utilized for biomarker assays. Among epigenetic biomarkers, most reports indicate GSTP1 hypermethylation as the diagnostic marker for prostate cancer; however, NKX2-5, CLSTN1, SPOCK2, SLC16A12, DPYS, and NSE1 also have been reported to be regulated by methylation mechanisms in prostate cancer. Current challenges in utilization of biomarkers in prostate cancer diagnosis and epidemiologic studies and potential solutions also are discussed.

  3. Biomarker Identification Using Text Mining

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    Hui Li

    2012-01-01

    Full Text Available Identifying molecular biomarkers has become one of the important tasks for scientists to assess the different phenotypic states of cells or organisms correlated to the genotypes of diseases from large-scale biological data. In this paper, we proposed a text-mining-based method to discover biomarkers from PubMed. First, we construct a database based on a dictionary, and then we used a finite state machine to identify the biomarkers. Our method of text mining provides a highly reliable approach to discover the biomarkers in the PubMed database.

  4. Conceitos de asma e instrumentos de levantamentos epidemiológicos de prevalência

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    M.M. Vasconcelos

    2004-07-01

    Full Text Available RESUMO: A asma, doença multifactorial, de alta prevalência, com recorrência frequente, acomete indivíduos independentemente de idade, sexo e área geográfica. Por não haver consenso quanto à sua definição, diversos questionários foram desenvolvidos para padronização dos critérios epidemiológicos de suspeição ou diagnóstico, entre eles o da Comunidade Europeia de Saúde Respiratória (European Community Respiratory Health Survey - ECRHS, ferramenta importante para o estudo da prevalência em adultos com idade entre 20 e 44 anos, conferindo melhoria da qualidade metodológica dos levantamentos epidemiológicos, tornando-os comparáveis em tempo e local. Os objectivos deste artigo são comentar a evolução do conceito de asma e suas repercussões sobre os levantamentos epidemiológicos, historiar os instrumentos utilizados nesses levantamentos, relevando a importância do ECRHS, e apresentar dados epidemiológicos de asma em 351 trabalhadores de hospital-escola, na cidade de Recife – Pernambuco - Brasil.REV PORT PNEUMOL 2004; X (4: 319-329 ABSTRACT: Introduction: Asthma, as a multifatorial disease, with high prevalence and frequent recurrence, attack people, independently of age, sex and geographical area. Because of lack of consensus about the definition of asthma, many questionnaires have been developed to standardize epidemiological criteria of suspicion and diagnosis. Among them, the European Community Respiratory Health Survey (ECRHS is an important tool for prevalence studies on adults aged from 20 to 44 years old, that represented a methodological improvement of epidemiological surveys, turning them comparable about time and place. The objectives of this article are to comment the evolution of asthma concepts and its repercussion on epidemiological surveys, as well as to chronicle the tools used on these surveys, emphasizing the importance of ECRHS and

  5. Associação entre fatores epidemiológicos e neoplasias mamárias em cadelas

    OpenAIRE

    Ramos, Carolina Silva [UNESP

    2011-01-01

    Tumor de mama é a neoplasia mais freqüente em cadelas, entretanto, há controvérsias sobre os fatores que influenciam o seu desenvolvimento. Em estudos epidemiológicos destaca-se que os fatores ambientais são responsáveis por, pelo menos, 80% da incidência do câncer de mama em humanos. Com o objetivo de estabelecer fatores ambientais que possam contribuir para o desenvolvimento das neoplasias mamárias em cadelas, foram avaliadas as cadelas que se atendidas no Hospital Veterinário Governador La...

  6. Caracterización clínico-epidemiológica y de laboratorio del Síndrome de West.

    OpenAIRE

    Marcelino Lizano Rabelo; Noelio Rafael Poza Carmona; Yanisbel Imara Rolo Naranjo

    2009-01-01

    Se describe un grupo de características clínico-epidemiológicas y de laboratorio relacionadas con esta enfermedad. Se realizó un estudio descriptivo de 39 pacientes con diagnóstico definitivo al egreso de Síndrome de West, pertenecientes al Hospital Pediátrico Docente Provincial “José Martí Pérez “ de Sancti Spíritus (enero 1999- diciembre 2008), se emplearon para el diagnóstico los criterios establecidos por la Liga Internacional Contra la Epilepsia (ILAE 2001), las variables del estudio fue...

  7. Chiral Biomarkers in Meteorites

    Science.gov (United States)

    Hoover, Richard B.

    2010-01-01

    The chirality of organic molecules with the asymmetric location of group radicals was discovered in 1848 by Louis Pasteur during his investigations of the rotation of the plane of polarization of light by crystals of sodium ammonium paratartrate. It is well established that the amino acids in proteins are exclusively Levorotary (L-aminos) and the sugars in DNA and RNA are Dextrorotary (D-sugars). This phenomenon of homochirality of biological polymers is a fundamental property of all life known on Earth. Furthermore, abiotic production mechanisms typically yield recemic mixtures (i.e. equal amounts of the two enantiomers). When amino acids were first detected in carbonaceous meteorites, it was concluded that they were racemates. This conclusion was taken as evidence that they were extraterrestrial and produced by abiologically. Subsequent studies by numerous researchers have revealed that many of the amino acids in carbonaceous meteorites exhibit a significant L-excess. The observed chirality is much greater than that produced by any currently known abiotic processes (e.g. Linearly polarized light from neutron stars; Circularly polarized ultraviolet light from faint stars; optically active quartz powders; inclusion polymerization in clay minerals; Vester-Ulbricht hypothesis of parity violations, etc.). This paper compares the measured chirality detected in the amino acids of carbonaceous meteorites with the effect of these diverse abiotic processes. IT is concluded that the levels observed are inconsistent with post-arrival biological contamination or with any of the currently known abiotic production mechanisms. However, they are consistent with ancient biological processes on the meteorite parent body. This paper will consider these chiral biomarkers in view of the detection of possible microfossils found in the Orgueil and Murchison carbonaceous meteorites. Energy dispersive x-ray spectroscopy (EDS) data obtained on these morphological biomarkers will be

  8. Hepcidin- A Burgeoning Biomarker

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    Hemkant Manikrao Deshmukh

    2017-10-01

    Full Text Available The discovery of hepcidin has triggered a virtual ignition of studies on iron metabolism and related disorders. The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism. The synthesis of hepcidin is induced by systemic iron levels and by inflammatory stimuli. Several human diseases are associated with variations in hepcidin concentrations. The evaluation of hepcidin in biological fluids is therefore a promising device in the diagnosis and management of medical situations in which iron metabolism is affected. Thus, it made us to recapitulate role of hepcidin as biomarker.

  9. Towards Improved Biomarker Research

    DEFF Research Database (Denmark)

    Kjeldahl, Karin

    This thesis takes a look at the data analytical challenges associated with the search for biomarkers in large-scale biological data such as transcriptomics, proteomics and metabolomics data. These studies aim to identify genes, proteins or metabolites which can be associated with e.g. a diet...... with very specific competencies. In order to optimize the basis of a sound and fruitful data analysis, suggestions are givenwhich focus on (1) collection of good data, (2) preparation of data for the data analysis and (3) a sound data analysis. If these steps are optimized, PLS is a also a very goodmethod...

  10. Tempos históricos, tempos físicos, tempos epidemiológicos: prováveis contribuições de Fernand Braudel e Ilya Prigogine ao pensamento epidemiológico

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    Sevalho Gil

    1997-01-01

    Full Text Available O texto é uma abordagem acerca do tempo enquanto categoria científica para a epidemiologia. A partir do aforismo tempo-lugar-pessoa, o tempo é apontado como elemento pouco pensado pela epidemiologia, embora esteja presente em vários dos seus conceitos. No entanto, o tema tem sido objeto de reflexão importante na movimentação recente de várias disciplinas, tais como a história, a geografia, a biologia e a física, e deve por isto representar para a epidemiologia um ponto de vista interessante, tanto no que concerne ao diálogo interdisciplinar quanto ao estabelecimento de um olhar crítico voltado para a própria disciplina. Com o objetivo de argumentar a respeito destes aspectos, apresenta-se o tempo histórico de Fernand Braudel e o tempo físico de Ilya Prigogine, construções teóricas que serão comparadas com um provável tempo epidemiológico. Ao final, usando a questão das infecções emergentes como exemplo, faz-se considerações sobre a aparente inadequação epistemológica do tempo epidemiológico para reconhecer e lidar com os aspectos sociais e históricos envolvidos na complexidade do adoecer humano coletivo.

  11. Ethics in epidemiological research A ética na pesquisa epidemiológica

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    Rita Barradas Barata

    2008-04-01

    Full Text Available This text focus, on a series of author's opinions, on the difficulties that the current system of regulation of ethics in research represents for the practice of the epidemiological research, in the Country. It introduces a few understandings concerning the present subject in the international literature, pointing out some of the most relevant themes and problems. It also examines part of the difficulties faced by Brazilian epidemiologists. The main topic developed in the article is the specificity of the science's reasoning that guides acting of the public health and epidemiology with repercussions for the practice of scientific research in this field, plenty different from the science's reasoning that preside medical practice and biomedical research. Hence the inadequacy of the ethical recommendations in force, all of them based on biomedical research, particularly at that with experimental design. It concludes with the indication that procedures adopted by the system of the ethics in research should be reviewed, adapting such procedures to the characteristics of different kinds of research.Este artigo reúne uma série de opiniões do autor sobre as dificuldades que o atual sistema de controle da ética em pesquisa representa para a prática da pesquisa epidemiológica no país. São apresentadas algumas posições referentes ao assunto presentes na literatura internacional, apontados alguns dos temas e problemas mais relevantes e discutidas algumas das dificuldades enfrentadas pelos epidemiologistas brasileiros. O argumento principal desenvolvido no artigo é a especificidade da lógica de atuação da saúde pública e da epidemiologia em seu interior com repercussões para a prática da pesquisa científica nesse campo, bastante diferente da lógica que preside a prática médica e a pesquisa biomédica. Daí a inadequação das recomendações éticas vigentes, todas elas baseadas na pesquisa biomédica, em particular, naquelas com

  12. Jornalismo científico e risco epidemiológico Scientific journalism and epidemiological risk

    Directory of Open Access Journals (Sweden)

    Olinda do Carmo Luiz

    2007-06-01

    Full Text Available A importância dos meios de comunicação na construção simbólica tem sido reconhecida por diversos segmentos. Dentre as inúmeras matérias nos jornais diários sobre saúde, muitas se referem a estudos médicos cujas fontes são publicações científicas tendo como foco um novo risco. A divulgação nos meios de comunicação de massa sobre os estudos de risco também é tema de editoriais e artigos em revistas científicas, enfocando o problema das distorções e a elaboração de notícias contraditórias. O presente artigo tem como objetivo explorar os significados e conteúdos da divulgação científica dos estudos sobre risco nos jornais diários de grande circulação. Foram analisadas as notícias e as respectivas publicações científicas que serviram de fonte durante o ano de 2000. Observou-se que "risco" é apresentado nas pesquisas científicas como uma "caixa preta" na acepção de Latour e que as notícias ocultam as controvérsias científicas e atribuem uma dimensão maior à associação entre hábitos comportamentais e a ocorrência das doenças, ressaltando ainda mais os aspectos individuais da abordagem epidemiológica em detrimento do enfoque coletivo.The importance of the communications media in the construction of symbols has been widely acknowledged. Many of the articles on health published in the daily newspapers mention medical studies, sourced from scientific publications focusing on new risks. The disclosure of risk studies in the mass media is also a topic for editorials and articles in scientific journals, focusing the problem of distortions and the appearance of contradictory news items. The purpose of this paper is to explore the meaning and content of disclosing scientific risk studies in large-circulation daily newspapers, analyzing news items published in Brazil and the scientific publications used as their sources during 2000. The "risk" is presented in the scientific research projects as a "black box

  13. Datos epidemiológicos en incapacidad temporal en el Instituto Nacional de la Seguridad Social

    Directory of Open Access Journals (Sweden)

    Luis Sánchez Galán

    Full Text Available El Instituto Nacional de la Seguridad Social (INSS es la entidad gestora de la seguridad social española, dotada de personalidad jurídica, que tiene encomendada la gestión y administración de las prestaciones económicas del sistema de la seguridad social. La acción protectora del Sistema de Seguridad Social comprende, entre otras, las prestaciones económicas por incapacidad temporal y por incapacidad laboral permanente. Los indicadores clásicos de la prestación de incapacidad temporal de incidencia, prevalencia y duración media de los procesos se ofrecen en la página web de la seguridad social: http://www.seg-social.es/Internet_1/Estadistica/Est/Otras_Prestaciones_de_la_Seguridad_Social/Incapacidad_Temporal/Incapacidadtemporal2015/index.htm. Otros datos epidemiológicos sobre pensiones de incapacidad completan las reseñas que el INSS ha incorporado en la sede electrónica de la seguridad social a través de la aplicación informática denominada ESTADISS, que permite obtener datos de las estadísticas de pensiones del Sistema de Seguridad Social. Conclusiones: Diversos datos de frecuencia en la prestación de incapacidad temporal, permiten analizar los diferentes procesos con mayor incidencia en la incapacidad temporal, pudiéndose afirmar que el lumbago (724.2 CIE 9 es el diagnóstico específico inicial más frecuente en los procesos de incapacidad temporal. Así mismo el grupo diagnóstico más frecuente es el de enfermedades del sistema osteomioarticular y del tejido conectivo. El grupo de diagnósticos de mayor duración media son las neoplasias. Siguiendo la Clasificación Nacional de Ocupaciones y superados los 365 días de duración de incapacidad temporal es el grupo de trabajadores de servicios, restauración, personales, protección y vendedores de comercio, el que acumula mayor número de procesos de incapacidad temporal.

  14. Indicações e perfil epidemiológico dos pacientes submetidos à ceratoplastia

    Directory of Open Access Journals (Sweden)

    Augusto Adam Netto

    2014-06-01

    Full Text Available Objetivo: Avaliar o perfil epidemiológico dos pacientes submetidos à ceratoplastia no estado de Santa Catarina e as principais indicações para este procedimento. Métodos: Foi realizado estudo observacional, descritivo e retrospectivo com dados de 1161 pacientes transplantados entre janeiro de 2008 e dezembro de 2010, de acordo com os prontuários obtidos na Central de Notificação, Captação e Distribuição de Órgãos e Tecidos de Santa Catarina. As variáveis registradas foram: idade, sexo, procedência, data do transplante, indicação e olho operado. Resultados: A média de idade foi de 45,51 anos e o sexo masculino foi mais prevalente (54,05%. O ceratocone foi a doença mais frequente (36,09%, seguido por falência do enxerto (15,89%, leucoma (11,92%, ceratopatia bolhosa (11,06%, distrofias (7,77%, úlcera (5,36%, perfuração corneana (5,27%, descemetocele (4,66%, ceratite herpética (1,12% e ectasia corneana (0,86%. A região do estado com maior número de casos foi a Grande Florianópolis (23,75%, sendo o ceratocone a principal indicação (30,91%. Leucoma e perfuração foram as principais indicações em pacientes com idade inferior a 10 anos, ceratocone nos pacientes entre 11 e 50 anos, falência do enxerto entre 51 e 60 anos e ceratopatia bolhosa nos pacientes acima de 61 anos. Conclusão: O ceratocone é a principal indicação para ceratoplastia no estado de Santa Catarina, com a média de idade de 31 anos. A maioria dos pacientes é do sexo masculino e proveniente da Grande Florianópolis.

  15. Factores epidemiológicos y psicosociales que inciden en los intentos suicidas

    Directory of Open Access Journals (Sweden)

    Wilfredo Guibert Reyes

    2001-04-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal, en el área de salud urbana del Policlínico "Marcio Manduley", del municipio Centro Habana con el propósito de identificar el comportamiento epidemiológico y de los factores psicosociales asociados al intento suicida (IS en el último trienio (1996-1998. La muestra estuvo conformada por 41 personas con intentos suicidas, residentes permanentes del área de salud que fueron reportados por el Departamento de Estadísticas, a los cuales se les aplicó el instrumento: encuesta sobre intento suicida. Las principales conclusiones fueron: la tasa de prevalencia del intento suicida en el área de salud se mantuvo estable; la depresión mayor, los sentimientos de culpa y/o desesperanza y el hogar desorganizado fueron los factores de riesgo principales que antecedieron al acto suicida; y la mayoría de los pacientes no recibieron atención de salud especializada después del intento, y de los que la recibieron, la mayoría la percibió como de regular calidadThe authors conducted a cross-sectional descriptive study in the health urban area of "Marcio Manduley" Polyclinic, in Centro Habana Municipality, in order to identify the epidemiologic behaviour and that of the psychosocial factors related to suicide attempt (SA in the last triennium (1996-1998. The sample consisted of 41 persons with SA that were permanent residents in the health area reported by the Statistics Department, which did a survey on suicide attempts. The main conclusion was that the prevalence rate of suicide attempt in the health area remained stable. A higher depression, guilt and/or hopelesness feelings and a disorganized home were the fundamental risk factors that preceded the suicide act. Most of the patients did not recieve specialized care after the attempt and many of those who had it considered it as ordinary

  16. Biomarkers in Vasculitis

    Science.gov (United States)

    Monach, Paul A.

    2014-01-01

    Purpose of review Better biomarkers are needed for guiding management of patients with vasculitis. Large cohorts and technological advances had led to an increase in pre-clinical studies of potential biomarkers. Recent findings The most interesting markers described recently include a gene expression signature in CD8+ T cells that predicts tendency to relapse or remain relapse-free in ANCA-associated vasculitis, and a pair of urinary proteins that are elevated in Kawasaki disease but not other febrile illnesses. Both of these studies used “omics” technologies to generate and then test hypotheses. More conventional hypothesis-based studies have indicated that the following circulating proteins have potential to improve upon clinically available tests: pentraxin-3 in giant cell arteritis and Takayasu’s arteritis; von Willebrand factor antigen in childhood central nervous system vasculitis; eotaxin-3 and other markers related to eosinophils or Th2 immune responses in eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome); and MMP-3, TIMP-1, and CXCL13 in ANCA-associated vasculitis. Summary New markers testable in blood and urine have the potential to assist with diagnosis, staging, assessment of current disease activity, and prognosis. However, the standards for clinical usefulness, in particular the demonstration of either very high sensitivity or very high specificity, have yet to be met for clinically relevant outcomes. PMID:24257367

  17. Estudio clínico-epidemiológico y molecular de Metapneumovirus Humano en pacientes con Infecciones Respiratorias Agudas (IRA) en Venezuela

    OpenAIRE

    Tovar H, Cerraf E; Moncho S, Alessandra; Fernandez S, David; Aguilar M, Marwan S; Morón, Dulce

    2014-01-01

    El Metapneumovirus Humano (MPVh) ha sido asociado con Infecciones Respiratorias Agudas (IRA) en pacientes de todas las edades. Estudios epidemiológicos indican la prevalencia del MPVh alrededor del mundo, sin embargo, en Venezuela poco se conoce sobre su comportamiento en la población. Este estudio pretende describir el comportamiento epidemiológico de la infección por MPVh en pacientes venezolanos. Se evaluaron por RT-PCR multiplex 1812 hisopados nasales (HN) provenientes de pacientes con di...

  18. ¿Cuál es el perfil epidemiológico de padecer burnout en profesores no universitarios de la Región de Murcia?

    OpenAIRE

    Isabel LATORRE REVIRIEGO; Juan SAEZ CARRERAS

    2009-01-01

    El burnout es un estado de pérdida emocional y mental que se desarrolla en profesiones con interacciones humanas. Un grupo de alto riesgo es el de los profesores. El objetivo de este estudio es analizar las características epidemiológicas del síndrome entre los docentes. Para ello diseñamos un estudio transversal mediante la cumplimentación de un cuestionario en una población de 200 profesores de niveles no universitarios de Murcia. Como variables se han medido: datos epidemiológicos, el nive...

  19. Atuação do enfermeiro no controle epidemiológico da hanseníase

    Directory of Open Access Journals (Sweden)

    Sara Augusta dos Santos

    1992-09-01

    Full Text Available Analisou-se seníase, na Seção de Dermatologia Sanitária do Hospital Universitário Pedro Ernesto, UERJ. Pretendeu-se alcançar três objetivos entre eles comparar a qualidade do controle epidemiológico dos casos novos de hanseníase em registro ativo de 1986, com os mesmos casos relativos ao período de 1987. Aplicou-se o método descritivo e análise de documentos dos prontuários desses clientes. Utilizou-se um formulário com questões de múltipla escolha e preenchimento de claros, totalizando 27 itens. Constatou-se que o enfermeiro interfere nas variáveis: exames para firmar diagnóstico, exames de contatos e educação para saúde, contribuindo para a melhoria da qualidade assistencial do hanseniano. Conclui-se que há diferença significativa na qualidade do controle epidemiológico da hanseníase entre os grupos constituídos.

  20. The epidemiologic transition in Peru La transición epidemiológica en el Perú

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    Maud M. T. E. Huynen

    2005-01-01

    Full Text Available En el presente trabajo se examina la transición epidemiológica en el Perú y se demuestra que los cambios observados en la situación de salud del país constituyen un buen ejemplo del modelo de transición no occidental que describe los cambios epidemiológicos producidos a lo largo del tiempo en países en desarrollo en función de tres etapas. Actualmente el Perú se encuentra en la tercera etapa de este modelo y tiene una carga de morbilidad que abarca tres componentes. Tiene, en primer lugar, problemas antiguos que aún no se han resuelto, como el de las enfermedades infecciosas "tradicionales" (por ej., las infecciones respiratorias agudas y el de las elevadas tasas de mortalidad materna. También tiene, en segundo lugar, algunos problemas que apenas empiezan a aflorar: las enfermedades cardiovasculares y las neoplasias malignas se están incrementando, el paludismo y otras enfermedades más antiguas están reapareciendo, y la infección por VIH y el sida, más algunas otras enfermedades, han surgido por primera vez. En tercer lugar, el Perú adolece de una poca disponibilidad de buenos servicios de salud. En este contexto, el presente trabajo examina la gran falta de equidad en el Perú en lo concerniente a algunos indicadores de salud importantes (por ej., la esperanza de vida, la tasa de mortalidad, la tasa de fecundidad, y el acceso a seguro médico y a servicios de salud, a la luz del concepto de "polarización epidemiológica". Este último es un proceso según el cual la distribución desigual de la riqueza, de los riesgos de salud, y de los servicios de atención sanitaria redunda en diferencias cada vez mayores en el estado de salud de una población, y en una "brecha de salud" que se ensancha progresivamente entre pobres y ricos. Demostramos que la situación de salud del Perú ilustra todas las características del modelo de transición polarizada y prolongada, que es una variante del modelo de transición no occidental y que

  1. [Autoantibodies as biomarkers].

    Science.gov (United States)

    Tron, François

    2014-01-01

    Activation and differentiation of autoreactive B-lymphocytes lead to the production of autoantibodies, which are thus the direct consequence of the autoimmune process. They often constitute biomarkers of autoimmune diseases and are measured by tests displaying various diagnosis sensitivity and specificity. Autoantibody titers can be correlated to the disease activity and certain autoantibody populations associated with particular clinical manifestations or tissue lesions. The demonstration that autoantibodies appear years before the onset of autoimmune diseases indicates that their presence in healthy individuals may be a predictive marker of the occurrence of disease. Certain autoantibodies could also be predictive markers of a therapeutic response to biologics and of the occurrence of side effects as well. Thus, autoantibodies are useful tools in the diagnosis and the management of patients with organ specific or non-organ specific autoimmune diseases at different steps of the autoimmune process. Copyright © 2013. Published by Elsevier Masson SAS.

  2. Biomarkers of adverse drug reactions.

    Science.gov (United States)

    Carr, Daniel F; Pirmohamed, Munir

    2018-02-01

    Adverse drug reactions can be caused by a wide range of therapeutics. Adverse drug reactions affect many bodily organ systems and vary widely in severity. Milder adverse drug reactions often resolve quickly following withdrawal of the casual drug or sometimes after dose reduction. Some adverse drug reactions are severe and lead to significant organ/tissue injury which can be fatal. Adverse drug reactions also represent a financial burden to both healthcare providers and the pharmaceutical industry. Thus, a number of stakeholders would benefit from development of new, robust biomarkers for the prediction, diagnosis, and prognostication of adverse drug reactions. There has been significant recent progress in identifying predictive genomic biomarkers with the potential to be used in clinical settings to reduce the burden of adverse drug reactions. These have included biomarkers that can be used to alter drug dose (for example, Thiopurine methyltransferase (TPMT) and azathioprine dose) and drug choice. The latter have in particular included human leukocyte antigen (HLA) biomarkers which identify susceptibility to immune-mediated injuries to major organs such as skin, liver, and bone marrow from a variety of drugs. This review covers both the current state of the art with regard to genomic adverse drug reaction biomarkers. We also review circulating biomarkers that have the potential to be used for both diagnosis and prognosis, and have the added advantage of providing mechanistic information. In the future, we will not be relying on single biomarkers (genomic/non-genomic), but on multiple biomarker panels, integrated through the application of different omics technologies, which will provide information on predisposition, early diagnosis, prognosis, and mechanisms. Impact statement • Genetic and circulating biomarkers present significant opportunities to personalize patient therapy to minimize the risk of adverse drug reactions. ADRs are a significant heath issue

  3. New biomarkers for sepsis

    Directory of Open Access Journals (Sweden)

    Li-xin XIE

    2013-01-01

    Full Text Available There is a higher sepsis rate in the intensive care unit (ICU patients, which is one of the most important causes for patient death, but the sepsis lacks specific clinical manifestations. Exploring sensitive and specific molecular markers for infection that accurately reflect infection severity and prognosis is very clinically important. In this article, based on our previous study, we introduce some new biomarkers with high sensitivity and specificity for the diagnosis and predicting the prognosis and severity of sepsis. Increase of serum soluble(s triggering receptor expressed on myeloid cells-1 (sTREM-1 suggests a poor prognosis of septic patients, and changes of locus rs2234237 of sTREM-1 may be the one of important mechanisms. Additionally, urine sTREM-1 can provide an early warning of possible secondary acute kidney injury (AKI in sepsis patients. Serum sCD163 level was found to be a more important factor than procalcitonin (PCT and C-reactive protein (CRP in prognosis of sepsis, especially severe sepsis. Moreover, urine sCD163 also shows excellent performance in the diagnosis of sepsis and sepsis-associated AKI. Circulating microRNAs, such as miR-150, miR-297, miR-574-5p, miR -146a , miR-223, miR -15a and miR-16, also play important roles in the evaluation of status of septic patients. In the foreseeable future, newly-emerging technologies, including proteomics, metabonomics and trans-omics, may exert profound effects on the discovery of valuable biomarkers for sepsis.

  4. Multiple Sclerosis Cerebrospinal Fluid Biomarkers

    Directory of Open Access Journals (Sweden)

    Gavin Giovannoni

    2006-01-01

    Full Text Available Cerebrospinal fluid (CSF is the body fluid closest to the pathology of multiple sclerosis (MS. For many candidate biomarkers CSF is the only fluid that can be investigated. Several factors need to be standardized when sampling CSF for biomarker research: time/volume of CSF collection, sample processing/storage, and the temporal relationship of sampling to clinical or MRI markers of disease activity. Assays used for biomarker detection must be validated so as to optimize the power of the studies. A formal method for establishing whether or not a particular biomarker can be used as a surrogate end-point needs to be adopted. This process is similar to that used in clinical trials, where the reporting of studies has to be done in a standardized way with sufficient detail to permit a critical review of the study and to enable others to reproduce the study design. A commitment must be made to report negative studies so as to prevent publication bias. Pre-defined consensus criteria need to be developed for MS-related prognostic biomarkers. Currently no candidate biomarker is suitable as a surrogate end-point. Bulk biomarkers of the neurodegenerative process such as glial fibrillary acidic protein (GFAP and neurofilaments (NF have advantages over intermittent inflammatory markers.

  5. Biomarkers for Detecting Mitochondrial Disorders

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    Josef Finsterer

    2018-01-01

    Full Text Available (1 Objectives: Mitochondrial disorders (MIDs are a genetically and phenotypically heterogeneous group of slowly or rapidly progressive disorders with onset from birth to senescence. Because of their variegated clinical presentation, MIDs are difficult to diagnose and are frequently missed in their early and late stages. This is why there is a need to provide biomarkers, which can be easily obtained in the case of suspecting a MID to initiate the further diagnostic work-up. (2 Methods: Literature review. (3 Results: Biomarkers for diagnostic purposes are used to confirm a suspected diagnosis and to facilitate and speed up the diagnostic work-up. For diagnosing MIDs, a number of dry and wet biomarkers have been proposed. Dry biomarkers for MIDs include the history and clinical neurological exam and structural and functional imaging studies of the brain, muscle, or myocardium by ultrasound, computed tomography (CT, magnetic resonance imaging (MRI, MR-spectroscopy (MRS, positron emission tomography (PET, or functional MRI. Wet biomarkers from blood, urine, saliva, or cerebrospinal fluid (CSF for diagnosing MIDs include lactate, creatine-kinase, pyruvate, organic acids, amino acids, carnitines, oxidative stress markers, and circulating cytokines. The role of microRNAs, cutaneous respirometry, biopsy, exercise tests, and small molecule reporters as possible biomarkers is unsolved. (4 Conclusions: The disadvantages of most putative biomarkers for MIDs are that they hardly meet the criteria for being acceptable as a biomarker (missing longitudinal studies, not validated, not easily feasible, not cheap, not ubiquitously available and that not all MIDs manifest in the brain, muscle, or myocardium. There is currently a lack of validated biomarkers for diagnosing MIDs.

  6. Evaluación epidemiológica de plaguicidas inhibidores de acetilcolinesterasa en Colombia, 1996-1997

    Directory of Open Access Journals (Sweden)

    Elizabeth Silva

    2000-09-01

    Full Text Available El programa de vigilancia epidemiológica de plaguicidas organofosforados y carbamatos (VEO fue creado mediante el establecimiento de convenios de cooperación y asistencia técnicocientífica entre el Laboratorio de Salud Ambiental del lnstituto Nacional de Salud y las seccionales de salud del país. El programa tiene como finalidad detectar precozmente los casos de absorción elevada de plaguicidas e impulsar el desarrollo de acciones de promoción, prevención y control, que disminuyan la incidencia de intoxicaciones agudas y los efectos crónicos producidos por los plaguicidas inhibidores de la acetilcolinesterasa (ACHE. Durante 1996 y 1997, participaron en el estudio 17 entidades territoriales de salud y 21.454 personas que presentaban riesgo de exposición a plaguicidas organofosforados y carbamatos. A estas personas se les realizaron 24.167 análisis de ACHE, mediante el método de Limperos y Ranta, utilizando el equipo de Lovibond. La prevalencia de valores anormales de ACHE fue de 6,1%, muy similar a las encontradas de 1993 a 1995. Las entidades territoriales de salud encontradas con mayores prevalencias después de realizar la estandarización directa fueron Bolívar (20,3% en 1996 y Córdoba (17,7% en 1997. Las variables asociadas con mayores prevalencias de anormalidad para ACHE fueron las aplicaciones aérea y terrestre en actividades económicas; el de banderero y mezclador-tanqueador-formulador en oficios y los grupos de edad de 18 a 25 años y de 6 a 11 años. Solamente 36,1% de los participantes en el estudio estaban afiliados al sistema general de seguridad social en salud (SGSSS; 63,9% no estaban cubiertos por el sistema y, de éstos, 7,1% tenia valores anormales de ACHE. La evaluación epidemiológica para 1996-1997 se comparó con la de los años anteriores y se determinó la población con mayor riesgo; se cuantificaron los niveles de intoxicación y se aportaron las conclusiones para fortalecer la vigilancia epidemiol

  7. La transición demográfico-epidemiológica en Chile, 1960-2001

    Directory of Open Access Journals (Sweden)

    Szot Meza Jorge

    2003-01-01

    Full Text Available Fundamento: En Chile se ha modificado de manera significativa la estructura demográfica y las causas de morbilidad y de mortalidad de la población en un período relativamente breve de tiempo. Estas variaciones se enmarcan dentro de los procesos denominados transición demográfica y transición epidemiológica respectivamente. El propósito de este trabajo es evidenciar la transición demográfica y la transición epidemiológica ocurridas en el país entre 1960 y 2001. Método: Se trata de un estudio de series temporales que recoge información demográfica y de mortalidad de Chile entre los años 1960 y 2001. Los datos fueron obtenidos de los Anuarios de Demografía del Instituto Nacional de Estadísticas (INE, de información producida por el Departamento de Estudios Prospectivos del Ministerio de Planificación y Cooperación y del Ministerio de Salud de Chile. Resultados: En 1960 un 39,6% de la población tenía menos de 14 años, la tasa de natalidad era de 36,3 por 1000, la tasa de mortalidad general de 12,3 por 1.000 y la tasa de mortalidad infantil de 120 por 1.000. El 44% de la mortalidad general se generaba en causas infecciosas y perinatales. En el año 2001 un 28% de la población tiene menos de 14 años, la tasa de natalidad es de 18,3 por 1.000, la tasa de mortalidad general de 5,4 por 1.000 y la tasa de mortalidad infantil de 8,9 por 1000. El 68% de la mortalidad general se produce por enfermedades crónicas. Conclusiones: En base a los resultados, es posible afirmar que Chile se encuentra en una fase tardía tanto de transición demográfica como de transición epidemiológica. Conocer la realidad de Chile aportará información a aquellos países de América Latina que se encuentren en fases más tempranas de este tipo de transiciones.

  8. Urinary Biomarkers of Brain Diseases

    Directory of Open Access Journals (Sweden)

    Manxia An

    2015-12-01

    Full Text Available Biomarkers are the measurable changes associated with a physiological or pathophysiological process. Unlike blood, urine is not subject to homeostatic mechanisms. Therefore, greater fluctuations could occur in urine than in blood, better reflecting the changes in human body. The roadmap of urine biomarker era was proposed. Although urine analysis has been attempted for clinical diagnosis, and urine has been monitored during the progression of many diseases, particularly urinary system diseases, whether urine can reflect brain disease status remains uncertain. As some biomarkers of brain diseases can be detected in the body fluids such as cerebrospinal fluid and blood, there is a possibility that urine also contain biomarkers of brain diseases. This review summarizes the clues of brain diseases reflected in the urine proteome and metabolome.

  9. Biomarkers of latent TB infection

    DEFF Research Database (Denmark)

    Ruhwald, Morten; Ravn, Pernille

    2009-01-01

    For the last 100 years, the tuberculin skin test (TST) has been the only diagnostic tool available for latent TB infection (LTBI) and no biomarker per se is available to diagnose the presence of LTBI. With the introduction of M. tuberculosis-specific IFN-gamma release assays (IGRAs), a new area...... of in vitro immunodiagnostic tests for LTBI based on biomarker readout has become a reality. In this review, we discuss existing evidence on the clinical usefulness of IGRAs and the indefinite number of potential new biomarkers that can be used to improve diagnosis of latent TB infection. We also present...... early data suggesting that the monocyte-derived chemokine inducible protein-10 may be useful as a novel biomarker for the immunodiagnosis of latent TB infection....

  10. Aspectos epidemiológicos dateníase-cisticercose na área endêmica de Lagamar, MG

    OpenAIRE

    Silva-Vergara, Mario León; Prata, Aluízio; Vieira, Cláudio de Oliveira; Castro, João Henrique; Micheletti, Luciane Giroto; Otaño, Arturo Santana; Franquini Júnior, João

    1995-01-01

    Um inquérito epidemiológico sobre teníase-cisticercose foi realizado em Lagamar- MG em 1992. Cadastradas 1109 casas com 3344 habitantes. O inquérito abrangeu 875 (86%) famílias e foi respondido por um informante que, em 80% dos casos, foi o pai. Na cidade havia 100 chiqueiros em 100 (11,4%) casas que albergavam 406 suínos, em condições extremamente precárias. Em 300 (34,2%) casas havia o antecedente de teníase em algum membro da família. O antecedente de convulsão foi relatado por 125 (14,2%)...

  11. Breath biomarkers in toxicology.

    Science.gov (United States)

    Pleil, Joachim D

    2016-11-01

    Exhaled breath has joined blood and urine as a valuable resource for sampling and analyzing biomarkers in human media for assessing exposure, uptake metabolism, and elimination of toxic chemicals. This article focuses current use of exhaled gas, aerosols, and vapor in human breath, the methods for collection, and ultimately the use of the resulting data. Some advantages of breath are the noninvasive and self-administered nature of collection, the essentially inexhaustible supply, and that breath sampling does not produce potentially infectious waste such as needles, wipes, bandages, and glassware. In contrast to blood and urine, breath samples can be collected on demand in rapid succession and so allow toxicokinetic observations of uptake and elimination in any time frame. Furthermore, new technologies now allow capturing condensed breath vapor directly, or just the aerosol fraction alone, to gain access to inorganic species, lung pH, proteins and protein fragments, cellular DNA, and whole microorganisms from the pulmonary microbiome. Future applications are discussed, especially the use of isotopically labeled probes, non-targeted (discovery) analysis, cellular level toxicity testing, and ultimately assessing "crowd breath" of groups of people and the relation to dose of airborne and other environmental chemicals at the population level.

  12. Analysis of biomarker data a practical guide

    CERN Document Server

    Looney, Stephen W

    2015-01-01

    A "how to" guide for applying statistical methods to biomarker data analysis Presenting a solid foundation for the statistical methods that are used to analyze biomarker data, Analysis of Biomarker Data: A Practical Guide features preferred techniques for biomarker validation. The authors provide descriptions of select elementary statistical methods that are traditionally used to analyze biomarker data with a focus on the proper application of each method, including necessary assumptions, software recommendations, and proper interpretation of computer output. In addition, the book discusses

  13. Estudo epidemiológico de pacientes com queimaduras por eletricidade atendidos em unidade de queimados em Recife – PE

    Directory of Open Access Journals (Sweden)

    Ana Claudia Siqueira Torquato

    2015-09-01

    Full Text Available Objetivo: verificar a frequência das queimaduras por eletricidade e perfil clínico-epidemiológico de pacientes atendidos na Unidade de Queimados em Recife-PE. Métodos: estudo retrospectivo, transversal e descritivo de pacientes com queimaduras por eletricidade atendidos na Unidade de Queimados do Hospital da Restauração (HR em Recife-PE, no período de janeiro 2007 a dezembro de 2008. Resultados: foram atendidos 115 pacientes com queimaduras por eletricidade no período de realização do estudo (média de 57,5 pacientes/ano, correspondendo a quase 8% de todas as queimaduras atendidas no serviço. Quanto ao sexo, 83,5% eram do sexo masculino e 16,5% eram do sexo feminino. A idade média foi de 27 anos. Ocorreu predominância do Médio queimado (70%. O acidente doméstico foi mais encontrado. Quanto ao tempo de hospitalização, aproximadamente 90% dos pacientes receberam alta com menos de dois meses de internação. Durante a evolução, 42,6% dos pacientes necessitaram de enxerto e 13% sofreram amputação. Nenhum óbito foi notificado no período de realização do estudo. Conclusões: a frequência de queimaduras por eletricidade em nosso estudo foi maior que as relatadas em outras séries. O perfil clínico- epidemiológico encontrado no presente estudo foi similar ao descrito na literatura.

  14. Perfil epidemiológico del accidente ofídico en las tierras bajas de Guatemala

    Directory of Open Access Journals (Sweden)

    Dennis Guerra-Centeno

    2017-03-01

    Full Text Available Se describe el perfil epidemiológico del accidente ofídico en las tierras bajas de Guatemala a partir del análisis de 305 expedientes de casos atendidos en los hospitales regionales de Escuintla y San Benito, Petén, entre 2008 y 2013. De los 305 casos, 169 correspondieron al Hospital Regional de Escuintla y 136 al Hospital Regional de San Benito Petén. Los casos del Hospital Regional de Escuintla correspondieron a pacientes provenientes de los departamentos de Escuintla, Santa Rosa, Chimaltenango, Retalhuleu, Suchitepéquez, Sacatepéquez, Sololá y Guatemala. Los casos del Hospital Regional de San Benito Petén correspondieron a pacientes provenientes del área centro y norte de Petén, y algunos referidos del área sur. La edad media de la víctima fue 25.2 años. La enfermedad afectó más a hombres (61.3% que a mujeres (38.7%. La mayoría de los afectados (28.3% eran agricultores. Las especies de serpiente que se consignaron en los expedientes con mayor frecuencia fueron Bothrops asper (serpiente barba amarilla en la región norte y Crotalus simus (serpiente cascabel en la región sur. La mayoría de las mordeduras ocurrieron en los miembros inferiores. Los eventos de mordedura ocurrieron durante el día y durante la noche en proporciones similares. El tiempo medio que tarda la víctima en llegar al hospital fue de 5.6 horas. Se describen también otros aspectos epidemiológicos y se discuten las implicaciones ecológicas y sociales de los datos generados.

  15. Perfil epidemiológico de dezesseis anos de uma unidade de terapia intensiva pediátrica

    Directory of Open Access Journals (Sweden)

    Paulo Roberto Einloft

    2002-12-01

    Full Text Available OBJETIVO: Revisar e descrever os dados epidemiológicos dos pacientes admitidos em uma unidade de terapia pediátrica brasileira (UTIP e compará-los aos aspectos clínicos associados aos índices de gravidade e mortalidade. Descrever as características desses pacientes, incluindo os dados demográficos, prevalência de doenças, índices de mortalidade e fatores associados. MÉTODOS: Os dados foram coletados retrospectivamente de todos os pacientes admitidos na UTIP de um hospital universitário entre 1978 e 1994. Os dados foram expressos em percentagens e comparados pelo teste qui-quadrado, calculando-se o risco relativo (RR com um intervalo de confiança de 95%, considerando-se um p<0,05. RESULTADOS: Foram selecionados 13.101 pacientes - em sua maioria meninos (58,4% - com doença clínica (73,1%, menores de 12 meses de idade (40,4% e eutróficos (69,5%. O índice geral de mortalidade foi de 7,4%. Os pacientes menores de 12 meses de idade mostraram um RR de 1,86 (CI 1,65-2,10; p<0,0001, enquanto que a desnutrição mostrou um RR de 2,98 (IC 2,64-3,36; p<0,0001. CONCLUSÕES: O levantamento epidemiológico mostrou que a mortalidade é maior entre desnutridos e menores de 12 meses de idade. A sepse foi a principal causa de morte.

  16. Biomarkers in acute heart failure.

    Science.gov (United States)

    Mallick, Aditi; Januzzi, James L

    2015-06-01

    The care of patients with acutely decompensated heart failure is being reshaped by the availability and understanding of several novel and emerging heart failure biomarkers. The gold standard biomarkers in heart failure are B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide, which play an important role in the diagnosis, prognosis, and management of acute decompensated heart failure. Novel biomarkers that are increasingly involved in the processes of myocardial injury, neurohormonal activation, and ventricular remodeling are showing promise in improving diagnosis and prognosis among patients with acute decompensated heart failure. These include midregional proatrial natriuretic peptide, soluble ST2, galectin-3, highly-sensitive troponin, and midregional proadrenomedullin. There has also been an emergence of biomarkers for evaluation of acute decompensated heart failure that assist in the differential diagnosis of dyspnea, such as procalcitonin (for identification of acute pneumonia), as well as markers that predict complications of acute decompensated heart failure, such as renal injury markers. In this article, we will review the pathophysiology and usefulness of established and emerging biomarkers for the clinical diagnosis, prognosis, and management of acute decompensated heart failure. Copyright © 2015 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

  17. Biomarkers in inflammatory bowel diseases

    DEFF Research Database (Denmark)

    Bennike, Tue; Birkelund, Svend; Stensballe, Allan

    2014-01-01

    Unambiguous diagnosis of the two main forms of inflammatory bowel diseases (IBD): Ulcerative colitis (UC) and Crohn's disease (CD), represents a challenge in the early stages of the diseases. The diagnosis may be established several years after the debut of symptoms. Hence, protein biomarkers...... for early and accurate diagnostic could help clinicians improve treatment of the individual patients. Moreover, the biomarkers could aid physicians to predict disease courses and in this way, identify patients in need of intensive treatment. Patients with low risk of disease flares may avoid treatment...... with medications with the concomitant risk of adverse events. In addition, identification of disease and course specific biomarker profiles can be used to identify biological pathways involved in the disease development and treatment. Knowledge of disease mechanisms in general can lead to improved future...

  18. Biomarkers of replicative senescence revisited

    DEFF Research Database (Denmark)

    Nehlin, Jan

    2016-01-01

    Biomarkers of replicative senescence can be defined as those ultrastructural and physiological variations as well as molecules whose changes in expression, activity or function correlate with aging, as a result of the gradual exhaustion of replicative potential and a state of permanent cell cycle...... arrest. The biomarkers that characterize the path to an irreversible state of cell cycle arrest due to proliferative exhaustion may also be shared by other forms of senescence-inducing mechanisms. Validation of senescence markers is crucial in circumstances where quiescence or temporary growth arrest may...... be triggered or is thought to be induced. Pre-senescence biomarkers are also important to consider as their presence indicate that induction of aging processes is taking place. The bona fide pathway leading to replicative senescence that has been extensively characterized is a consequence of gradual reduction...

  19. LABORATORY BIOMARKERS FOR ANKYLOSING SPONDYLITIS

    Directory of Open Access Journals (Sweden)

    E. N. Aleksandrova

    2017-01-01

    Full Text Available Ankylosing spondylitis (AS is a chronic inflammatory disease from a group of spondyloarthritis (SpA, which is characterized by lesions of the sacroiliac joints and spine with the common involvement of entheses and peripheral joints in the pathological process. Advances in modern laboratory medicine have contributed to a substantial expansion of the range of pathogenetic, diagnostic, and prognostic biomarkers of AS. As of now, there are key pathogenetic biomarkers of AS (therapeutic targets, which include tumor necrosis factor-α (TNF-α, interleukin 17 (IL-17, and IL-23. Among the laboratory diagnostic and prognostic biomarkers, HLA-B27 and C-reactive protein are of the greatest value in clinical practice; the former for the early diagnosis of the disease and the latter for the assessment of disease activity, the risk of radiographic progression and the efficiency of therapy. Anti-CD74 antibodies are a new biomarker that has high sensitivity and specificity values in diagnosing axial SpA at an early stage. A number of laboratory biomarkers, including calprotectin, matrix metalloproteinase-3 (MMP-3, vascular endothelial growth factor, Dickkopf-1 (Dkk-1, and C-terminal telopeptide of type II collagen (CTX II do not well reflect disease activity, but may predict progressive structural changes in the spine and sacroiliac joints in AS. Blood calprotectin level monitoring allows the effective prediction of a response to therapy with TNF inhibitors and anti-IL-17А monoclonal antibodies. The prospects for the laboratory diagnosis of AS are associated with the clinical validation of candidate biomarkers during large-scale prospective cohort studies and with a search for new proteomic, transcriptomic and genomic markers, by using innovative molecular and cellular technologies.

  20. Biomarkers in scleroderma: Current status

    Directory of Open Access Journals (Sweden)

    Latika Gupta

    2017-01-01

    Full Text Available Scleroderma is an autoimmune disease characterized by indolent obliterative vasculopathy and widespread fibrosis. The two main morphological manifestations of the disease overlap and may make it difficult to separate activity from damage. Many patients, especially those with the limited subset of the disease, have an indolent course without clear-cut inflammatory manifestations. There is a felt need for validated biomarkers, which can differentiate activity from damage, and yet be sensitive to change with therapy. Multiplex arrays of biomarkers have ushered an era of targeted or personalized medicine based on phenotypic characteristics in an individual.

  1. Investigación cualitativa e imaginación epidemiológica, una relación vital

    Directory of Open Access Journals (Sweden)

    Popay J.

    2003-01-01

    Full Text Available Este artículo presume que la «imaginación epidemiológica» tiene un papel relevante en el futuro desarrollo e implementación de políticas cuya finalidad sea mejorar la salud de la población y reducir las desigualdades de salud entre países y dentro de ellos. Sin embargo, si obviamos la contribución de la investigación cualitativa a la epidemiología fracasaremos en el desarrollo de ese potencial. Este artículo brevemente describe qué es la investigación cualitativa desde un punto de vista epidemiológico -qué tipo de «conocimiento» genera- y aborda cuestiones metodológicas (aproximaciones sobre recogida de datos, análisis e interpretación de resultados. Se presentan dos modelos diferentes sobre la relación entre la investigación cualitativa y cuantitativa. El primer modelo, denominado de intensificación, asume que los resultados de la investigación cualitativa enriquecen los resultados obtenidos mediante investigación cuantitativa y sugiere 3 roles para la investigación cualitativa: generar hipótesis que se podrán probar en la investigación cuantitativa, ayudar a construir medidas más sofisticadas de fenómenos sociales y explicar resultados sorprendentes obtenidos mediante una aproximación cuantitativa. Por el contrario, el modelo epistemológico sugiere que la investigación cualitativa es diferente de la cuantitativa en el sentido de que realiza una contribución única: estudia aspectos que otras aproximaciones no pueden analizar; mejora y amplía el conocimiento al profundizar en aspectos conceptuales y teóricos; cambia el equilibrio de poder entre los investigadores y el objeto de investigación, y por último desafía los métodos que utiliza la epidemiología tradicional para conocer el mundo social. Este artículo ilustra los diferentes tipos de contribuciones con ejemplos de la investigación cualitativa y finalmente discute cómo la investigación cualitativa "digna de confianza" puede evaluarse.

  2. Resultados de la vigilancia epidemiológica de diabetes mellitus en hospitales notificantes del Perú, 2012

    Directory of Open Access Journals (Sweden)

    Willy Ramos

    Full Text Available Objetivos: Describir los hallazgos de un año de la vigilancia epidemiológica de diabetes mellitus en hospitales piloto pertenecientes al sistema de vigilancia de diabetes (VD. Materiales y métodos. Estudio transversal que incluyó a los pacientes diabéticos notificados durante el 2012 en 18 hospitales piloto del Perú. Se revisó la base de datos de la VD, obteniéndose variables epidemiológicas y de laboratorio como edad, sexo, tipo de diabetes, complicaciones, comorbilidad, microalbuminuria, glucosa en ayunas y hemoglobina glucosilada (HbA1c al momento de captación por la VD y en el último control. Resultados. Se encontraron 2959 casos. Al momento de captación por la VD, 91,2% contaba con glicemia en ayunas de los cuales, 65,4% presentaba valor ≥ 130 mg/dL. El 8,9% contaba con estudio de microalbuminuria, el 20,5% de ellos presentaba microalbuminuria y el 6,5% proteinuria. En total, 1025 pacientes tuvieron consulta de control; 93,1% contaba con glicemia en ayunas y 22,3% con HbA1c. El 63,5% tenía glicemia en ayunas ≥ 130 mg/dL y 73,4% HbA1c ≥ 7,0%. La complicación más frecuente fue la neuropatía (21,4% y la comorbilidad más frecuente la hipertensión arterial (10,5%. Se observó casos de tuberculosis y cáncer, de los cánceres, el más frecuente fue el de mama, principalmente en mujeres posmenopáusicas. Conclusiones. La VD muestra que en los diabéticos de los hospitales piloto en los que se cuenta con resultados de laboratorio existe una alta frecuencia control glicémico inadecuado y pobre adherencia al tratamiento. La alta frecuencia de complicaciones encontrada evidencia la necesidad de fortalecer el diagnóstico temprano

  3. Resultados de la vigilancia epidemiológica de diabetes mellitus en hospitales notificantes del Perú, 2012

    Directory of Open Access Journals (Sweden)

    Willy Ramos

    Full Text Available Objetivos: Describir los hallazgos de un año de la vigilancia epidemiológica de diabetes mellitus en hospitales piloto pertenecientes al sistema de vigilancia de diabetes (VD. Materiales y métodos. Estudio transversal que incluyó a los pacientes diabéticos notificados durante el 2012 en 18 hospitales piloto del Perú. Se revisó la base de datos de la VD, obteniéndose variables epidemiológicas y de laboratorio como edad, sexo, tipo de diabetes, complicaciones, comorbilidad, microalbuminuria, glucosa en ayunas y hemoglobina glucosilada (HbA1c al momento de captación por la VD y en el último control. Resultados. Se encontraron 2959 casos. Al momento de captación por la VD, 91,2% contaba con glicemia en ayunas de los cuales, 65,4% presentaba valor 130 mg/dL. El 8,9% contaba con estudio de microalbuminuria, el 20,5% de ellos presentaba microalbuminuria y el 6,5% proteinuria. En total, 1025 pacientes tuvieron consulta de control; 93,1% contaba con glicemia en ayunas y 22,3% con HbA1c. El 63,5% tenía glicemia en ayunas 130 mg/dL y 73,4% HbA1c 7,0%. La complicación más frecuente fue la neuropatía (21,4% y la comorbilidad más frecuente la hipertensión arterial (10,5%. Se observó casos de tuberculosis y cáncer, de los cánceres, el más frecuente fue el de mama, principalmente en mujeres posmenopáusicas. Conclusiones. La VD muestra que en los diabéticos de los hospitales piloto en los que se cuenta con resultados de laboratorio existe una alta frecuencia control glicémico inadecuado y pobre adherencia al tratamiento. La alta frecuencia de complicaciones encontrada evidencia la necesidad de fortalecer el diagnóstico temprano

  4. Características epidemiológicas de la mortalidad neonatal en el Perú, 2011-2012

    Directory of Open Access Journals (Sweden)

    Jeannette Ávila

    Full Text Available Objetivos. Describir las características epidemiológicas de las defunciones neonatales en el Perú. Materiales y métodos. Estudio descriptivo basado en notificaciones al Subsistema Nacional de Vigilancia Epidemiológica Perinatal y Neonatal (SNVEPN realizadas en los años 2011-2012. Se aplicó el método de captura y recaptura para calcular el subregistro de la notificación y estimar la tasa de mortalidad neonatal (TMN nacional y por departamentos. Se respondieron las preguntas dónde, cuándo, quiénes y por qué fallecen los recién nacidos (RN. Resultados. Se notificaron al SNVEPN 6748 defunciones neonatales, subregistro 52,9%. Se estimó una TMN nacional de 12,8 muertes/1000 nacidos vivos. Se encontró que 16% de las defunciones ocurrieron en domicilio y de estas 74,2% fueron en la región sierra, con predominio de zonas rurales y distritos pobres. El 30% falleció en las primeras 24 horas y el 42% entre los días 1 y 7 de vida. El 60,6% fueron RN prematuros y un 39,4% fueron RN de término. El 37% tuvieron peso normal, el 29,4% bajo peso y un 33,6%, muy bajo peso. La mortalidad neonatal evitable fue 33% siendo mayor en la zona urbana y sierra. El 25,1% falleció por causas relacionadas con la prematuridad-inmaturidad; 23,5% por infecciones; 14,1% por asfixia y causas relacionadas con la atención del parto y 11% por malformación congénita letal. Conclusiones. La mortalidad neonatal en el Perú es diferenciado por escenarios; mientras en la costa predominan los daños relacionados con prematuridad- inmaturidad, la sierra y selva registran mayor mortalidad neonatal evitable con predominancia de asfixia e infecciones

  5. Early-Phase Studies of Biomarkers

    DEFF Research Database (Denmark)

    Pepe, Margaret S.; Janes, Holly; Li, Christopher I.

    2016-01-01

    of a positive biomarker test in cases (true positive) to cost associated with a positive biomarker test in controls (false positive). Guidance is offered on soliciting the cost/benefit ratio. The calculations are based on the longstanding decision theory concept of providing a net benefit on average...... impact on patient outcomes of using the biomarker to make clinical decisions....

  6. Rostrocaudal Dynamics of CSF Biomarkers

    NARCIS (Netherlands)

    Tarnaris, A.; Toma, A.K.; Chapman, M.D.; Petzold, A.F.S.; Keir, G.; Kitchen, N.D.; Watkins, L.D.

    2011-01-01

    The rostrocaudal gradient (RCG) of markers present in cerebrospinal fluid (CSF) has not been studied adequately due to lack of appropriate control populations and ethical restrictions. The aim of this study is to understand the rostrocaudal gradient of CSF biomarkers. We contacted a study comparing

  7. Imaging Biomarkers for Adult Medulloblastomas

    DEFF Research Database (Denmark)

    Keil, V C; Warmuth-Metz, M; Reh, C

    2017-01-01

    BACKGROUND AND PURPOSE: The occurrence of medulloblastomas in adults is rare; nevertheless, these tumors can be subdivided into genetic and histologic entities each having distinct prognoses. This study aimed to identify MR imaging biomarkers to classify these entities and to uncover differences ...

  8. Biomarkers of satiation and satiety

    NARCIS (Netherlands)

    Graaf, de C.; Blom, W.A.M.; Smeets, P.A.M.; Stafleu, A.; Hendriks, H.F.J.

    2004-01-01

    This review's objective is to give a critical summary of studies that focused on physiologic measures relating to subjectively rated appetite, actual food intake, or both. Biomarkers of satiation and satiety may be used as a tool for assessing the satiating efficiency of foods and for understanding

  9. Bias in Peripheral Depression Biomarkers

    DEFF Research Database (Denmark)

    Carvalho, André F; Köhler, Cristiano A; Brunoni, André R

    2016-01-01

    BACKGROUND: To aid in the differentiation of individuals with major depressive disorder (MDD) from healthy controls, numerous peripheral biomarkers have been proposed. To date, no comprehensive evaluation of the existence of bias favoring the publication of significant results or inflating effect...

  10. Biomarkers of spontaneous preterm birth

    DEFF Research Database (Denmark)

    Polettini, Jossimara; Cobo, Teresa; Kacerovsky, Marian

    2017-01-01

    biomarkers associated with PTB published from January 2005 to March 2014. Retrieved citations (3631) were screened, and relevant studies (33) were selected for full-text reading. Ten studies were included in the review. Forty-two PTB-related proteins were reported, and RANTES and IL-10 (three studies...

  11. Investigações epidemiológicas sobre demência nos países em desenvolvimento

    Directory of Open Access Journals (Sweden)

    M Scazufca

    2002-12-01

    Full Text Available Na medida em que a população mundial está envelhecendo, a demência está se constituindo em importante problema de saúde pública, particularmente nos países em desenvolvimento. Investigações epidemiológicas nestes países são escassas e apresentam dificuldades metodológicas adicionais, principalmente no que se refere à adequação sociocultural dos instrumentos utilizados para a definição de casos. Tendo em vista estas preocupações, foi fundado o "Grupo de Pesquisa em Demência 10/66", que é constituído por uma rede internacional de pesquisadores, predominantemente de países em desenvolvimento. O nome do grupo tem como referência o paradoxo de que menos de 10% dos estudos populacionais sobre demência são dirigidos aos 2/3 ou mais de casos de pessoas com demência que vivem em países em desenvolvimento. O objetivo do artigo é atualizar informações da literatura sobre as diferenças de prevalência e incidência de demência encontradas em países desenvolvidos e em desenvolvimento.

  12. Investigações epidemiológicas sobre demência nos países em desenvolvimento

    Directory of Open Access Journals (Sweden)

    Scazufca M

    2002-01-01

    Full Text Available Na medida em que a população mundial está envelhecendo, a demência está se constituindo em importante problema de saúde pública, particularmente nos países em desenvolvimento. Investigações epidemiológicas nestes países são escassas e apresentam dificuldades metodológicas adicionais, principalmente no que se refere à adequação sociocultural dos instrumentos utilizados para a definição de casos. Tendo em vista estas preocupações, foi fundado o "Grupo de Pesquisa em Demência 10/66", que é constituído por uma rede internacional de pesquisadores, predominantemente de países em desenvolvimento. O nome do grupo tem como referência o paradoxo de que menos de 10% dos estudos populacionais sobre demência são dirigidos aos 2/3 ou mais de casos de pessoas com demência que vivem em países em desenvolvimento. O objetivo do artigo é atualizar informações da literatura sobre as diferenças de prevalência e incidência de demência encontradas em países desenvolvidos e em desenvolvimento.

  13. Subsistencia ocasional del patrón epidemiológico clásico de la uta (Leishmaniasis tegumentaria

    Directory of Open Access Journals (Sweden)

    Arístides Herrer

    2004-01-01

    Full Text Available En una pequeña comunidad indígena de los Andes peruanos se ha observado la subsistencia endémica de la "uta" conservando el patrón epidemiológico clásico para esta forma de la leishmaniasis tegumentaria: aparte de la benignidad de la infección, elevada prevalencia de la enfermedad en la población infantil y sin diferencia alguna en cuanto al sexo, como acontecía con anterioridad al advenimiento de los modernos insecticidas de contacto. Se supone que se trate de una situación especial, debida al aislamiento en que ha permanecido la comunidad mencionada, la altitud sobre el nivel del mar de la localidad donde se ha establecido, y al ambiente rural que aún predomina en ella. Se informa también sobre la presencia de Lutzomyia verrucarum, Lu. peruensis y del resultado que se ha obtenido en la búsqueda de leishmaniasis natural en perros y algunos mamíferos silvestres.

  14. Comportamiento epidemiológico del Programa de Detección del Cáncer Bucal en Puerto Padre

    Directory of Open Access Journals (Sweden)

    Elva Zayas Sánchez

    2014-10-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal en el municipio de Puerto Padre, provincia de Las Tunas, Cuba, en el período comprendido desde febrero de 2011 a febrero de 2012, con el objetivo de describir el comportamiento epidemiológico del programa de detección del cáncer bucal. De un universo de 105 pacientes remitidos se seleccionó una muestra de 99 pacientes. Se estudiaron variables cuantitativas y cualitativas, la información se obtuvo de fuentes secundarias, como las historias clínicas, los registros de las unidades y los indicadores de los servicios. Se encontró que predominó dentro de los pacientes remitidos el grupo de adultos mayores (mayores de 60 años y el sexo masculino. El servicio estomatológico del área de salud de Vázquez remitió el mayor número de pacientes, fue bajo el porciento de pacientes remitidos con relación al total de examinados. El factor de riesgo de mayor prevalencia fue el tabaquismo, la exposición solar superó al alcoholismo. La lesión más frecuente fue la leucoplasia y la zona de la cavidad bucal más afectada el labio inferior. Fue alto el porciento de pacientes remitidos con neoplasias malignas

  15. Distribución actual e importancia epidemiológica de las especies de triatominos (Reduviidae: Triatominae en Colombia

    Directory of Open Access Journals (Sweden)

    Jorge A. Molina

    2000-12-01

    Full Text Available Se presenta la distribución geográfica y la importancia epidemiológica en la transmisión de la enfermedad de Chagas de las 23 especies de triatominos presentes en Colombia, tomando como base los registros bibliográficos existentes en el pais y las colecciones de referencia del Laboratorio de Entomologia del Instituto Nacional de Salud y del Centro de Investigaciones en Microbiologia y Parasitologia Tropical de la Universidad de los Andes; además, se realiza un análisis de las condiciones ecológicas en las cuales han sido registrados triatominos en los paises con fronteras con Colombia para poder establecer la presencia de posibles especies que aún no se han registrado en nuestro pais. De esta manera. existe la posibilidad de tener en Colombia especies con hábitos silvestres como: Alberprosenia malheiroi. Belminus laportei y Cavernicola lenti, preentes todas ellas en los departamentos amazónicos; Triatoma nigromaculata en la Cordillera Oriental y con hábitos intradomiciliarios; Panstrongylus chinai con posibilidad de encontrarse en hábitats selváticos o en las viviendas de los colonos de la Amazonia debido a su atracción por la luz y Alberprosenia goyovargasien hábitats silvestres de la frontera con Venezuela. Se resalta la importancia de la vigilancia entomológica a nivel nacional como estrategia para reforzar los estudios de triatominos silvestres en Colombia.

  16. Aspectos clínicos e epidemiológicos de pacientes queimados internados em um Hospital de Ensino

    Directory of Open Access Journals (Sweden)

    Samanta Flor Montes

    2011-04-01

    Full Text Available Os objetivos foram: caracterizar os pacientes queimados segundo as variáveis epidemiológicas e clínicas e identificar os tratamentos, procedimentos invasivos e as complicações. Trata-se de um estudo retrospectivo, descritivo e quantitativo. A amostra constituiu-se de 138 pacientes queimados internados em um hospital de ensino, no período de janeiro de 2003 a dezembro de 2007, de Uberaba-MG. Dos 138 pacientes internados, 98 (71,0% eram do gênero masculino e a média de idade foi de 26,1 anos. O tempo médio de internação foi de 16,2 dias; 93 (67,4% eram de natureza acidental e a principal causa 68 (49,3% foi a chama aberta. A superfície corporal queimada média foi de 20,8% e a maioria 122 (88,4% apresentou queimadura de 2° grau. A terapia tópica mais utilizada 93 (67,4% foi a sulfadiazina de prata. A sondagem vesical de demora foi instalada em 47 (34,0% pacientes; 30 (21,7% foram submetidos à enxertia e 28 (20,3% ao desbridamento; 14 (10,1% apresentaram infecção da lesão.

  17. Aspectos epidemiológicos dateníase-cisticercose na área endêmica de Lagamar, MG

    Directory of Open Access Journals (Sweden)

    Mario León Silva-Vergara

    1995-12-01

    Full Text Available Um inquérito epidemiológico sobre teníase-cisticercose foi realizado em Lagamar- MG em 1992. Cadastradas 1109 casas com 3344 habitantes. O inquérito abrangeu 875 (86% famílias e foi respondido por um informante que, em 80% dos casos, foi o pai. Na cidade havia 100 chiqueiros em 100 (11,4% casas que albergavam 406 suínos, em condições extremamente precárias. Em 300 (34,2% casas havia o antecedente de teníase em algum membro da família. O antecedente de convulsão foi relatado por 125 (14,2% famílias. O início das convulsões na idade adulta foi caracterizado em 39 (3 7,8% famílias e o antecedente de doenças mentais foi relatado em 53 (6% casas. Os exames parasitológicos de fezes mostraram ovos de Taenia spp em 24 (1,3% das 1850 amostras examinadas.

  18. Violência sexual contra meninos: dados epidemiológicos, características e consequências

    Directory of Open Access Journals (Sweden)

    Jean Von Hohendorff

    2012-06-01

    Full Text Available O objetivo desse ensaio teórico é contribuir para a produção de conhecimento sobre a violência sexual masculina no Brasil, tendo em vista a escassez de estudos nacionais. A carência de conhecimento teórico-prático torna a atuação profissional um desafio. Buscaram-se trabalhos científicos em bases de dados nacionais, porém apenas um estudo foi encontrado. Diante disso, recorreu-se a publicações internacionais. Dados epidemiológicos da violência sexual masculina no Brasil, bem como as características das vítimas, dos autores e das situações de violência sexual, além das possíveis consequências deste tipo de violência, foram conteúdos abordados nesse estudo. A dificuldade dos meninos em relatar suas experiências de violência sexual e as dúvidas quanto à orientação sexual são aspectos frequentes na discussão da literatura encontrada. Conclui-se que, embora em menor prevalência, a violência sexual masculina ocorre e necessita de estratégias preventivas e terapêuticas. Além disso, é necessário o incremento de estudos nacionais sobre a temática.

  19. Malária no Brasil: panorama epidemiológico na última década

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    Barata Rita de Cássia B.

    1995-01-01

    Full Text Available Este artigo apresenta, de maneira resumida, as principais alterações que marcaram a ocorrência de malária, no Brasil, nesta última década. Chama-se a atenção para o processo de focalização da doença, com a concentração da transmissão em áreas, relativamente restritas, da região amazônica. A mudança na situação epidemiológica acarreta a revisãoconceitual, levando ao abandono da concepção de "doença de massa" e à elaboração da teoria focal. Do mesmo modo, as ações de controle sofrem os impactos das transformações ocorridas e as tentativas de erradicação são abandonadas e substituídas por medidas de controle diversificadas e adaptadas a cada localidade. As novas propostas, oriundas da Conferência Ministerial de Amsterdam, são apresentadas e comentadas.

  20. Systems biology and biomarker discovery

    Energy Technology Data Exchange (ETDEWEB)

    Rodland, Karin D.

    2010-12-01

    Medical practitioners have always relied on surrogate markers of inaccessible biological processes to make their diagnosis, whether it was the pallor of shock, the flush of inflammation, or the jaundice of liver failure. Obviously, the current implementation of biomarkers for disease is far more sophisticated, relying on highly reproducible, quantitative measurements of molecules that are often mechanistically associated with the disease in question, as in glycated hemoglobin for the diagnosis of diabetes [1] or the presence of cardiac troponins in the blood for confirmation of myocardial infarcts [2]. In cancer, where the initial symptoms are often subtle and the consequences of delayed diagnosis often drastic for disease management, the impetus to discover readily accessible, reliable, and accurate biomarkers for early detection is compelling. Yet despite years of intense activity, the stable of clinically validated, cost-effective biomarkers for early detection of cancer is pathetically small and still dominated by a handful of markers (CA-125, CEA, PSA) first discovered decades ago. It is time, one could argue, for a fresh approach to the discovery and validation of disease biomarkers, one that takes full advantage of the revolution in genomic technologies and in the development of computational tools for the analysis of large complex datasets. This issue of Disease Markers is dedicated to one such new approach, loosely termed the 'Systems Biology of Biomarkers'. What sets the Systems Biology approach apart from other, more traditional approaches, is both the types of data used, and the tools used for data analysis - and both reflect the revolution in high throughput analytical methods and high throughput computing that has characterized the start of the twenty first century.

  1. Implementation of proteomic biomarkers: making it work.

    Science.gov (United States)

    Mischak, Harald; Ioannidis, John P A; Argiles, Angel; Attwood, Teresa K; Bongcam-Rudloff, Erik; Broenstrup, Mark; Charonis, Aristidis; Chrousos, George P; Delles, Christian; Dominiczak, Anna; Dylag, Tomasz; Ehrich, Jochen; Egido, Jesus; Findeisen, Peter; Jankowski, Joachim; Johnson, Robert W; Julien, Bruce A; Lankisch, Tim; Leung, Hing Y; Maahs, David; Magni, Fulvio; Manns, Michael P; Manolis, Efthymios; Mayer, Gert; Navis, Gerjan; Novak, Jan; Ortiz, Alberto; Persson, Frederik; Peter, Karlheinz; Riese, Hans H; Rossing, Peter; Sattar, Naveed; Spasovski, Goce; Thongboonkerd, Visith; Vanholder, Raymond; Schanstra, Joost P; Vlahou, Antonia

    2012-09-01

    While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implementation. Some of the problems lie in suboptimal biomarker discovery and validation, especially lack of validated platforms with well-described performance characteristics to support biomarker qualification. These issues have been acknowledged and are being addressed, raising the hope that valid biomarkers may start accumulating in the foreseeable future. However, successful biomarker discovery and qualification alone does not suffice for successful implementation. Additional challenges include, among others, limited access to appropriate specimens and insufficient funding, the need to validate new biomarker utility in interventional trials, and large communication gaps between the parties involved in implementation. To address this problem, we propose an implementation roadmap. The implementation effort needs to involve a wide variety of stakeholders (clinicians, statisticians, health economists, and representatives of patient groups, health insurance, pharmaceutical companies, biobanks, and regulatory agencies). Knowledgeable panels with adequate representation of all these stakeholders may facilitate biomarker evaluation and guide implementation for the specific context of use. This approach may avoid unwarranted delays or failure to implement potentially useful biomarkers, and may expedite meaningful contributions of the biomarker community to healthcare. © 2012 The Authors. European Journal of Clinical Investigation © 2012 Stichting European Society for Clinical Investigation Journal Foundation.

  2. Biomarkers of PTSD: military applications and considerations

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    Amy Lehrner

    2014-08-01

    Full Text Available Background: Although there are no established biomarkers for posttraumatic stress disorder (PTSD as yet, biological investigations of PTSD have made progress identifying the pathophysiology of PTSD. Given the biological and clinical complexity of PTSD, it is increasingly unlikely that a single biomarker of disease will be identified. Rather, investigations will more likely identify different biomarkers that indicate the presence of clinically significant PTSD symptoms, associate with risk for PTSD following trauma exposure, and predict or identify recovery. While there has been much interest in PTSD biomarkers, there has been less discussion of their potential clinical applications, and of the social, legal, and ethical implications of such biomarkers. Objective: This article will discuss possible applications of PTSD biomarkers, including the social, legal, and ethical implications of such biomarkers, with an emphasis on military applications. Method: Literature on applications of PTSD biomarkers and on potential ethical and legal implications will be reviewed. Results: Biologically informed research findings hold promise for prevention, assessment, treatment planning, and the development of prophylactic and treatment interventions. As with any biological indicator of disorder, there are potentially positive and negative clinical, social, legal, and ethical consequences of using such biomarkers. Conclusions: Potential clinical applications of PTSD biomarkers hold promise for clinicians, patients, and employers. The search for biomarkers of PTSD should occur in tandem with an interdisciplinary discussion regarding the potential implications of applying biological findings in clinical and employment settings.

  3. Biomarkers of PTSD: military applications and considerations.

    Science.gov (United States)

    Lehrner, Amy; Yehuda, Rachel

    2014-01-01

    Although there are no established biomarkers for posttraumatic stress disorder (PTSD) as yet, biological investigations of PTSD have made progress identifying the pathophysiology of PTSD. Given the biological and clinical complexity of PTSD, it is increasingly unlikely that a single biomarker of disease will be identified. Rather, investigations will more likely identify different biomarkers that indicate the presence of clinically significant PTSD symptoms, associate with risk for PTSD following trauma exposure, and predict or identify recovery. While there has been much interest in PTSD biomarkers, there has been less discussion of their potential clinical applications, and of the social, legal, and ethical implications of such biomarkers. This article will discuss possible applications of PTSD biomarkers, including the social, legal, and ethical implications of such biomarkers, with an emphasis on military applications. Literature on applications of PTSD biomarkers and on potential ethical and legal implications will be reviewed. Biologically informed research findings hold promise for prevention, assessment, treatment planning, and the development of prophylactic and treatment interventions. As with any biological indicator of disorder, there are potentially positive and negative clinical, social, legal, and ethical consequences of using such biomarkers. Potential clinical applications of PTSD biomarkers hold promise for clinicians, patients, and employers. The search for biomarkers of PTSD should occur in tandem with an interdisciplinary discussion regarding the potential implications of applying biological findings in clinical and employment settings.

  4. Implementation of proteomic biomarkers: making it work

    Science.gov (United States)

    Mischak, Harald; Ioannidis, John PA; Argiles, Angel; Attwood, Teresa K; Bongcam-Rudloff, Erik; Broenstrup, Mark; Charonis, Aristidis; Chrousos, George P; Delles, Christian; Dominiczak, Anna; Dylag, Tomasz; Ehrich, Jochen; Egido, Jesus; Findeisen, Peter; Jankowski, Joachim; Johnson, Robert W; Julien, Bruce A; Lankisch, Tim; Leung, Hing Y; Maahs, David; Magni, Fulvio; Manns, Michael P; Manolis, Efthymios; Mayer, Gert; Navis, Gerjan; Novak, Jan; Ortiz, Alberto; Persson, Frederik; Peter, Karlheinz; Riese, Hans H; Rossing, Peter; Sattar, Naveed; Spasovski, Goce; Thongboonkerd, Visith; Vanholder, Raymond; Schanstra, Joost P; Vlahou, Antonia

    2012-01-01

    While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe major obstacles and possible solutions to ease valid biomarker implementation. Some of the problems lie in suboptimal biomarker discovery and validation, especially lack of validated platforms with well-described performance characteristics to support biomarker qualification. These issues have been acknowledged and are being addressed, raising the hope that valid biomarkers may start accumulating in the foreseeable future. However, successful biomarker discovery and qualification alone does not suffice for successful implementation. Additional challenges include, among others, limited access to appropriate specimens and insufficient funding, the need to validate new biomarker utility in interventional trials, and large communication gaps between the parties involved in implementation. To address this problem, we propose an implementation roadmap. The implementation effort needs to involve a wide variety of stakeholders (clinicians, statisticians, health economists, and representatives of patient groups, health insurance, pharmaceutical companies, biobanks, and regulatory agencies). Knowledgeable panels with adequate representation of all these stakeholders may facilitate biomarker evaluation and guide implementation for the specific context of use. This approach may avoid unwarranted delays or failure to implement potentially useful biomarkers, and may expedite meaningful contributions of the biomarker community to healthcare. PMID:22519700

  5. Proteomic and metabolomic approaches to biomarker discovery

    CERN Document Server

    Issaq, Haleem J

    2013-01-01

    Proteomic and Metabolomic Approaches to Biomarker Discovery demonstrates how to leverage biomarkers to improve accuracy and reduce errors in research. Disease biomarker discovery is one of the most vibrant and important areas of research today, as the identification of reliable biomarkers has an enormous impact on disease diagnosis, selection of treatment regimens, and therapeutic monitoring. Various techniques are used in the biomarker discovery process, including techniques used in proteomics, the study of the proteins that make up an organism, and metabolomics, the study of chemical fingerprints created from cellular processes. Proteomic and Metabolomic Approaches to Biomarker Discovery is the only publication that covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution.  The book describes methods, and presents a standard operating procedure for sample selection, preparation, and storage, as well as data analysis...

  6. Meeting Report--NASA Radiation Biomarker Workshop

    Energy Technology Data Exchange (ETDEWEB)

    Straume, Tore; Amundson, Sally A,; Blakely, William F.; Burns, Frederic J.; Chen, Allen; Dainiak, Nicholas; Franklin, Stephen; Leary, Julie A.; Loftus, David J.; Morgan, William F.; Pellmar, Terry C.; Stolc, Viktor; Turteltaub, Kenneth W.; Vaughan, Andrew T.; Vijayakumar, Srinivasan; Wyrobek, Andrew J.

    2008-05-01

    A summary is provided of presentations and discussions from the NASA Radiation Biomarker Workshop held September 27-28, 2007, at NASA Ames Research Center in Mountain View, California. Invited speakers were distinguished scientists representing key sectors of the radiation research community. Speakers addressed recent developments in the biomarker and biotechnology fields that may provide new opportunities for health-related assessment of radiation-exposed individuals, including for long-duration space travel. Topics discussed include the space radiation environment, biomarkers of radiation sensitivity and individual susceptibility, molecular signatures of low-dose responses, multivariate analysis of gene expression, biomarkers in biodefense, biomarkers in radiation oncology, biomarkers and triage following large-scale radiological incidents, integrated and multiple biomarker approaches, advances in whole-genome tiling arrays, advances in mass-spectrometry proteomics, radiation biodosimetry for estimation of cancer risk in a rat skin model, and confounding factors. Summary conclusions are provided at the end of the report.

  7. Suicídio, lesões e envenenamento em adolescentes: um estudo epidemiológico Suicidio, lesiones y envenemiento de adolescentes: un estudio epidemiológico Suicide, lesions and poisoning of adolescents: an epidemiological study

    Directory of Open Access Journals (Sweden)

    Ana Maria Fortaleza Teixeira

    1997-05-01

    Full Text Available Trata-se de um estudo epidemiológico dos casos de Suicídio e Lesões auto-infligidas (E950 a E959 e Lesões em que se ignora se foram acidental ou intencionalmente infligidas (E980 a E989 em adolescentes atendidos no setor de urgências psiquiátricas de um hospital-escola de Ribeirão Preto (S.P., durante o período de 1988 a 1991. Os diagnósticos foram agrupados segundo o CID-9. Os dados foram obtidos a partir do Serviço de Estatística do Hospital. O sexo feminino predominou nos 4 anos nos dois grupos diagnósticos. Observou-se um aumento dos casos de E950 a E959 no decorrer do período; enquanto houve uma diminuição de E980 a E989; em adolescentes.La presente investigación consta de un estudio epidemiológico de los casos de suicidio y lesiones auto-inflingidas (E950 a E959 y lesiones en que se ignora si fueron acidentales o intencionales (E980 a E989. La población fue adolescentes asistidos en el Sector de Urgencias Psiquiátricas, de un hospital universitário de la ciudad de Ribeirão Preto (S.P., durante el período de 1988 a 1991. Los datos fueron obtenidos en el Servicio de Estadística del Hospital; se agruparon los casos según diagnósticos (CID-9 y datos demográficos relevantes. Los resultados han evidenciado: el predominio del sexo femenino en los dos grupos diagnósticos y un aumento de los casos de E950 a E959, en cuanto hubo una disminución de los E980 a E989 entre los adolescentes, en el periodo estudiado.This is an epidemiological study on Self-Inflicted Suicide and Lesions (E950 to E959 that we do not know if they are accidentally or intentionally inflicted (E980 to E989 among adolescents attended in a Psychiatric Ward at an Emergency Service in Ribeirão Preto, S.P., Brazil, from 1988 to 1991. The diagnoses were grouped according to CID-9. Data were obtained from the Hospital Statistics Service. The feminine sex predominated in the 4 years and in both diagnoses. It was observed that the occurrence of E950 to E959

  8. Chronic Obstructive Pulmonary Disease Biomarkers

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    Tatsiana Beiko

    2016-04-01

    Full Text Available Despite significant decreases in morbidity and mortality of cardiovascular diseases (CVD and cancers, morbidity and cost associated with chronic obstructive pulmonary disease (COPD continue to be increasing. Failure to improve disease outcomes has been related to the paucity of interventions improving survival. Insidious onset and slow progression halter research successes in developing disease-modifying therapies. In part, the difficulty in finding new therapies is because of the extreme heterogeneity within recognized COPD phenotypes. Novel biomarkers are necessary to help understand the natural history and pathogenesis of the different COPD subtypes. A more accurate phenotyping and the ability to assess the therapeutic response to new interventions and pharmaceutical agents may improve the statistical power of longitudinal clinical studies. In this study, we will review known candidate biomarkers for COPD, proposed pathways of pathogenesis, and future directions in the field.

  9. Glycoscience aids in biomarker discovery

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    Serenus Hua1,2 & Hyun Joo An1,2,*

    2012-06-01

    Full Text Available The glycome consists of all glycans (or carbohydrates within abiological system, and modulates a wide range of important biologicalactivities, from protein folding to cellular communications.The mining of the glycome for disease markers representsa new paradigm for biomarker discovery; however, this effortis severely complicated by the vast complexity and structuraldiversity of glycans. This review summarizes recent developmentsin analytical technology and methodology as applied tothe fields of glycomics and glycoproteomics. Mass spectrometricstrategies for glycan compositional profiling are described, as arepotential refinements which allow structure-specific profiling.Analytical methods that can discern protein glycosylation at aspecific site of modification are also discussed in detail.Biomarker discovery applications are shown at each level ofanalysis, highlighting the key role that glycoscience can play inhelping scientists understand disease biology.

  10. Candidate immune biomarkers for radioimmunotherapy.

    Science.gov (United States)

    Levy, Antonin; Nigro, Giulia; Sansonetti, Philippe J; Deutsch, Eric

    2017-08-01

    Newly available immune checkpoint blockers (ICBs), capable to revert tumor immune tolerance, are revolutionizing the anticancer armamentarium. Recent evidence also established that ionizing radiation (IR) could produce antitumor immune responses, and may as well synergize with ICBs. Multiple radioimmunotherapy combinations are thenceforth currently assessed in early clinical trials. Past examples have highlighted the need for treatment personalization, and there is an unmet need to decipher immunological biomarkers that could allow selecting patients who could benefit from these promising but expensive associations. Recent studies have identified potential predictive and prognostic immune assays at the cellular (tumor microenvironment composition), genomic (mutational/neoantigen load), and peripheral blood levels. Within this review, we collected the available evidence regarding potential personalized immune biomarker-directed radiation therapy strategies that might be used for patient selection in the era of radioimmunotherapy. Copyright © 2017. Published by Elsevier B.V.

  11. El perfil epidemiológico del sobrepeso y la obesidad y sus principales comorbilidades en la ciudad de Cartagena de Indias Epidemiological profile of overweight and obesity and its main comorbidities in the city of Cartagena de Indias

    Directory of Open Access Journals (Sweden)

    Fernando Manzur

    2009-10-01

    Full Text Available Introducción: la obesidad es una condición compleja multifactorial, que tiene componentes genéticos y ambientales, y dispara diversas anormalidades, según la predisposición de los individuos y de las poblaciones. Las repercusiones más frecuentes del sobrepeso y la obesidad se asocian con la aparición de diferentes enfermedades crónicas, entre las que se encuentran la enfermedad cardiovascular, la diabetes y las enfermedades del aparato locomotor. Se ha comprobado que el riesgo de que aparezcan estas enfermedades crónicas en la población, aumenta de manera progresiva a partir de un índice de masa corporal de 21. Según cálculos recientes de la Organización Mundial de la Salud, en los últimos años se ha producido un aumento de la incidencia mundial de sobrepeso que llega a 1.600 millones y de obesidad que alcanzó 400 millones en 2005. Además, se prevé que estas cifras se eleven más y lleguen hasta 2.300 millones y 700 millones, respectivamente en 2015. Objetivo: conocer el perfil epidemiológico del sobrepeso y la obesidad, y evaluar la relación con sus principales comorbilidades como la hipertensión arterial, la diabetes mellitus y algunas dislipidemias en la población adulta de Cartagena de Indias. Métodos: estudio transversal analítico, en el que se evaluaron 749 personas por muestreo aleatorio estratificado de las diferentes zonas de Cartagena, aplicando un formato de encuesta estructurada, con el fin de obtener las variables sociodemográficas y antropométricas. Para las variables bioquímicas se determinó glucemia en ayunas, colesterol total, colesterol HDL y triglicéridos. Resultados: se evidencia una prevalencia alta de sobrepeso y obesidad, que sumados constituyen 62% de la población (41% de sobrepeso y 21% de obesidad. Se determinó la prevalencia de obesidad abdominal según los criterios del ATP III, encontrándose que 41,8% de la población presentó obesidad abdominal, de éstos 39,3% mostraba hipertensi

  12. Biomarkers in adult posthemorrhagic hydrocephalus.

    Science.gov (United States)

    Hua, Cong; Zhao, Gang

    2017-08-01

    Posthemorrhagic hydrocephalus is a severe complication following intracranial hemorrhage. Posthemorrhagic hydrocephalus is often associated with high morbidity and mortality and serves as an important clinical predictor of adverse outcomes after intracranial hemorrhage. Currently, no effective medical intervention exists to improve functional outcomes in posthemorrhagic hydrocephalus patients because little is still known about the mechanisms of posthemorrhagic hydrocephalus pathogenesis. Because a better understanding of the posthemorrhagic hydrocephalus pathogenesis would facilitate development of clinical treatments, this is an active research area. The purpose of this review is to describe recent progress in elucidation of molecular mechanisms that cause posthemorrhagic hydrocephalus. What we are certain of is that the entry of blood into the ventricular system and subarachnoid space results in release of lytic blood products which cause a series of physiological and pathological changes in the brain. Blood components that can be linked to pathology would serve as disease biomarkers. From studies of posthemorrhagic hydrocephalus, such biomarkers are known to mutually synergize to initiate and promote posthemorrhagic hydrocephalus progression. These findings suggest that modulation of biomarker expression or function may benefit posthemorrhagic hydrocephalus patients.

  13. La paradoja de la transición epidemiológicaThe paradox of epidemiological transition

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    José Manuel Arriaga López

    2014-10-01

    Full Text Available En el año dos mil se celebró en la ciudad de Nueva York la Cumbre del Milenio, en donde se aprobó la Declaración del milenio. En esta, tomando como base la problemática existente a nivel global, se establecieron los Objetivos del Milenio. Estos constituyen un plan convenido entre todas las naciones del mundo y las instituciones de desarrollo más importantes a nivel mundial, y en los cuales se proponen: (1 Erradicar la pobreza extrema y el hambre. (2 Lograr la enseñanza primaria universal. (3 Promover la igualdad entre los géneros y la autonomía de la mujer; (4 reducir la mortalidad infantil. (5 Mejorar la salud materna. (6 Combatir el VIH/SIDA, el paludismo y otras enfermedades. (7 Garantizar la sostenibilidad del medio ambiente. (8 Fomentar una asociación mundial para el desarrollo. De estos objetivos, al menos cuatro involucran de manera directa al sector salud y de ellos todos incluyen al perfil epidemiológico clásico de nuestro país. Sin embargo, hacia el 2010, cuando se presenta el Tercer informe de avances en el cumplimiento de los objetivos de desarrollo del milenio, se evidenció que aún se está lejos de cumplir alguno de los objetivos. Además, mientras no es posible resolver los temas prioritarios para el sistema de salud, empieza a ser evidente el aumento de casos de enfermedades como diabetes mellitus, hipertensión arterial, dislipidemias y otras, que tienen como consecuencia complicaciones como infartos de miocardio, falla cardíaca, eventos cerebrovasculares y otras complicaciones que saturan los servicios de salud, dando como resultado objetivos prioritarios no cumplidos y el surgimiento de problemas de salud que eran considerados poco prevalentes en Guatemala.

  14. Valoración epidemiológica de las actividades de atención primaria de salud

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    Silvia Martínez Calvo

    2003-02-01

    Full Text Available Se analiza el concepto de atención primaria de salud (APS y se describen sus actividades básicas explícitas en la clásica Declaración de Alma-Atá, conjuntamente con una sintética valoración epidemiológica de esas actividades y su aplicación por el equipo de salud del consultorio, cuyo quehacer en los últimos 10 años se ha afianzado, prioritaria y paradójicamente, en la ejecución acrítica de programas de control, lo que tiende a tergiversar su encargo social. En las actuales circunstancias en que se debate el sistema nacional de salud, el tema pretende estimular alternativas que definitivamente lo reformen, como las dirigidas a reorientar el desempeño del Médico y la Enfermera de Familia, esencialmente sustentado en la APS.The concept of Primary Health Care is analyzed and its basic activities explained in the classical Alma-Atá Declaration are described together with the presentation of a summarized epidemiological assessment of these activities and their carrying out by the health team of the doctor´s office, whose work in the last 10 years has focused, in a prioritized and paradoxical way, on the non-critical implementation of control programs and this tends to distort its social mission. Under the present circumstances in which the national health care system is under discussion, the topic of this paper attempts to encourage alternatives that will finally reform it like those aimed at re-orient the performance of the family physician and nurse that is essentially based on the Primary Health Care.

  15. Estudo epidemiológico das fraturas mandibulares em hospital público da cidade de São Paulo

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    Antonio Augusto Ferreirinha Leporace

    Full Text Available OBJETIVO: Analisar a frequência epidemiológica de fraturas mandibulares correlacionando gênero, faixa etária, fatores etiológicos, localização anatômica, e tipos de traços de fratura. MÉTODOS: Estudo retrospectivo nos prontuários de 883 pacientes portadores de fraturas faciais, atendidos no Pronto Socorro do Hospital Geral de Vila Penteado, pelo Serviço de Cirurgia e Traumatologia Buco Maxilo Facial (São Paulo - Brasil, num período de três anos (janeiro de 2004 a dezembro de 2006. RESULTADOS: Dos 883 pacientes avaliados, 270 apresentaram fraturas mandibulares (30,5 %. O gênero masculino foi o mais acometido (76,7% na faixa etária de 20 a 29 anos (33,0%, o fator etiológico de maior freqüência foi acidente com veículos automotores (35,2%, o corpo da mandíbula foi a localização anatômica mais atingida (47,4% e os traços únicos prevaleceram (76,7%. CONCLUSÃO: As fraturas, em sua maioria, foram simples (traço único, localizadas em corpo mandibular, e destacadas no sexo masculino, na faixa etária de 20 a 29 anos, além do que o fator etiológico mais comum foi acidente com veículos automotores.

  16. Algunas variables clínico-epidemiológicas de la tuberculosis pulmonar. Puerto Padre, 2008-2012

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    Yoenny Peña García

    2015-12-01

    Full Text Available La tuberculosis es tan antigua como la humanidad, a pesar de existir desde tiempos remotos no puede ser considerada como una enfermedad del pasado. Se realizó un estudio descriptivo retrospectivo, para determinar algunas variables clínico epidemiológicas de la tuberculosis en el municipio de Puerto Padre, en el quinquenio 2008-2012. Se obtuvieron los siguientes resultados: la tendencia de la tuberculosis fue estacionaria en ese período, pero a partir del año 2009 ha tenido un ligero incremento, con una tendencia ascendente en los últimos cuatro años. El sexo más afectado fue el masculino, para un 82,6%, y el 43,5% fue del grupo de edad de 45-64 años; la forma clínica pulmonar es la de mayor frecuencia, con un 95,7% y los de baciloscopia positiva un 65,2%. Los factores de riesgo que más se presentaron fueron el albergamiento prolongado en instituciones cerradas, con un 34,8%, el alcoholismo, con un 26,1% y la edad mayor de 65 años, con un 21,7%. Los reclusos tuvieron la mayor incidencia, un 26,1%, seguidos de los desocupados, con cuatro casos (17,4% y de las amas de casa y jubilados, con tres casos cada uno, para un 13%. Hubo deficiencias en el diagnóstico, ya que un 52,2% se diagnosticó en la atención secundaria y el 48,8% de los casos fueron diagnosticados con más de dos meses de haber comenzado los síntomas.

  17. Conocimientos sobre la enfermedad de Chagas y factores de riesgo en comunidades epidemiológicamente diferentes de Argentina

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    Sanmartino Mariana

    2000-01-01

    Full Text Available Actualmente, el control de la enfermedad de Chagas se basa en acciones químicas contra la vinchuca. Sin embargo, existen factores de riesgo como la falta de higiene y el desorden que serían responsables de la persistencia de focos de triatominos. Teniendo en cuenta que las comunidades expuestas al riesgo de contraer la enfermedad poseen escasos conocimientos sobre ella, se definió el nivel óptimo de conocimientos y se determinó el nivel medio de conocimientos de los habitantes de dos zonas epidemiológicamente diferentes de Argentina y se identificaron los factores de riesgo presentes en ambas. El nivel óptimo de conocimientos se definió por 25 "nociones elementales" sobre la enfermedad, a partir de las cuales se elaboraron los cuestionarios para evaluar el nivel medio de conocimientos. Los resultados obtenidos reflejaron un predominio de los factores de riesgo relacionados con la construcción de las viviendas y el desorden y un limitado nivel de conocimientos sobre la enfermedad. Resultó deficiente el conocimiento de información básica sobre la enfermedad, relacionada, por ejemplo, con el reconocimiento de las ninfas y el mecanismo de transmisión. Un mejor conocimiento del tema supondría un importante avance en la lucha contra la enfermedad de Chagas, conduciendo a los habitantes de áreas endémicas a una mejor comprensión de su realidad y a la adquisición de hábitos que les permitan ser los protagonistas de su propio bienestar.

  18. Mapeamento Epidemiológico das Parasitoses Intestinais em Seis Bairros do Município de Araraquara/SP

    Directory of Open Access Journals (Sweden)

    Viviane Ferre de Souza

    2015-12-01

    Full Text Available No Brasil, grandes inquéritos coproparasitológicos foram realizados até a década de 70. Nos últimos anos, contamos apenas com trabalhos isolados, que nem sempre podem ser comparados. Entretanto, nas regiões com infra-estrutura urbana deficiente, os inquéritos mostram que grande parte da população residente encontra-se parasitada (Gross et al., 1994: Santana et al., 1994. O estudo epidemiológico de quaisquer parasitas intestinais proporciona diversas informações, especialmente quanto à insalubridade do meio, nível e extensão do saneamento básico de uma região e também quanto aos hábitos higiênicos da população em estudo. Desta forma, neste estudo tivemos como objetivo caracterizar a incidência de parasitoses intestinais em moradores de seis bairros do município de Araraquara/SP. Nossos resultados demonstraram a grande incidência de parasitas intestinais. A Endolimax nana foi o parasita intestinal mais encontrado. Embora não sendo patogênico, sua existência revela a exposição destas pessoas a contaminantes fecais. A Giardia lamblia foi o parasita intestinal patogênico mais encontrado. Houve similaridade de acometimento das parasitoses tanto no sexo feminino quanto no masculino. O bairro Selmi Dei obteve o maior índice dessas parasitoses, caracterizando-se como o bairro de maior preocupação para saúde pública do município de Araraquara/SP.

  19. Epidemiological studies are like cherries, one draws another Los estudios epidemiológicos son como las cerezas, van una detrás de la otra

    Directory of Open Access Journals (Sweden)

    Nuno Lunet

    2009-10-01

    Full Text Available The proverb "Words are like cherries", meaning that when you start talking subjects pop up and you end up with long conversations, just like cherries coming out of the plate in chains when you pick one, may also be applied to epidemiological research. A sequence of epidemiological studies, each being drawn from the previous, is presented as an example of how each investigation may raise new questions to be addressed in following studies. This description stresses the need for appropriate planning and the usefulness of pilot testing to depict inadequacies that can hardly be anticipated without field work. I intend to illustrate how epidemiological research can provide a deep approach to research questions, as long as findings are properly interpreted and suboptimal methodological options are taken into account in future investigations.El proverbio "Las palabras son como las cerezas" que expresa cómo cuando empezamos a hablar los asuntos van surgiendo de manera encadenada y terminamos con largas conversaciones, del mismo modo en que las cerezas que salen del plato encadenadas cuando cogemos una, puede también puede ser aplicado a la investigación epidemiológica. Una secuencia de estudios epidemiológicos, cada uno derivado del anterior, se presenta como un ejemplo de cómo cada investigación puede derivar en nuevas cuestiones en los estudios siguientes. Esta descripción subraya la necesidad de una planificación adecuada así como la utilidad de los estudios piloto para describir las deficiencias que difícilmente podrían haber sido anticipadas sin trabajo de campo. Se pretende ilustrar como la investigación epidemiológica puede proporcionar un enfoque profundo a cuestiones de investigación, siempre y cuando los resultados sean interpretados correctamente y las opciones metodológicas subóptimas sean tenidas en cuenta en futuras investigaciones.

  20. ¿Cuál es el perfil epidemiológico de padecer burnout en profesores no universitarios de la Región de Murcia?

    Directory of Open Access Journals (Sweden)

    Isabel LATORRE REVIRIEGO

    2009-01-01

    Full Text Available El burnout es un estado de pérdida emocional y mental que se desarrolla en profesiones con interacciones humanas. Un grupo de alto riesgo es el de los profesores. El objetivo de este estudio es analizar las características epidemiológicas del síndrome entre los docentes. Para ello diseñamos un estudio transversal mediante la cumplimentación de un cuestionario en una población de 200 profesores de niveles no universitarios de Murcia. Como variables se han medido: datos epidemiológicos, el nivel de estrés y sus consecuencias y el burnout mediante el Maslach Burnout Inventory. Los resultados han demostrado una relación significativa entre el nivel de estrés/burnout y las consecuencias, la edad y la antigüedad laboral, y no en función del sexo. Además, encontramos un menor nivel de agotamiento y despersonalización, y una menor realización personal que la muestra de referencia, siendo la dimensión que mejor se ha relacionado con el quemado de los docentes la del cansancio emocional (p<0.0001 seguida de la realización personal (p<0.003 y finalmente la despersonalización (p<0.01. Nuestro perfil epidemiológico de mayor riesgo ha resultado ser el de una mujer de 43 años de edad, soltera, sin hijos y con una antigüedad menor a 19 años.

  1. Biomarker Qualification: Toward a Multiple Stakeholder Framework for Biomarker Development, Regulatory Acceptance, and Utilization.

    Science.gov (United States)

    Amur, S; LaVange, L; Zineh, I; Buckman-Garner, S; Woodcock, J

    2015-07-01

    The discovery, development, and use of biomarkers for a variety of drug development purposes are areas of tremendous interest and need. Biomarkers can become accepted for use through submission of biomarker data during the drug approval process. Another emerging pathway for acceptance of biomarkers is via the biomarker qualification program developed by the Center for Drug Evaluation and Research (CDER, US Food and Drug Administration). Evidentiary standards are needed to develop and evaluate various types of biomarkers for their intended use and multiple stakeholders, including academia, industry, government, and consortia must work together to help develop this evidence. The article describes various types of biomarkers that can be useful in drug development and evidentiary considerations that are important for qualification. A path forward for coordinating efforts to identify and explore needed biomarkers is proposed for consideration. © 2015 American Society for Clinical Pharmacology and Therapeutics.

  2. Biomarkers of carcinogen exposure and early effects.

    OpenAIRE

    2006-01-01

    The purpose of this review is to summarise the current situation regarding the types and uses of biomarkers of exposure and effect for the main classes of food-derived genotoxic carcinogens, and to consider some aspects of the intercomparison between these biomarkers. The biomarkers of exposure and early effects of carcinogens that have been most extensively developed are those for genotoxic agents and for compounds that generate hydroxyl radicals and other reactive radical species, and it is...

  3. Biomarkers of HIV-associated Cancer

    OpenAIRE

    Flepisi, Brian Thabile; Bouic, Patrick; Sissolak, Gerhard; Rosenkranz, Bernd

    2014-01-01

    Cancer biomarkers have provided great opportunities for improving the management of cancer patients by enhancing the efficiency of early detection, diagnosis, and efficacy of treatment. Every cell type has a unique molecular signature, referred to as biomarkers, which are identifiable characteristics such as levels or activities of a myriad of genes, proteins, or other molecular features. Biomarkers can facilitate the molecular definition of cancer, provide information about the course of can...

  4. Biomarkers of PTSD: military applications and considerations

    OpenAIRE

    Amy Lehrner; Rachel Yehuda

    2014-01-01

    Background: Although there are no established biomarkers for posttraumatic stress disorder (PTSD) as yet, biological investigations of PTSD have made progress identifying the pathophysiology of PTSD. Given the biological and clinical complexity of PTSD, it is increasingly unlikely that a single biomarker of disease will be identified. Rather, investigations will more likely identify different biomarkers that indicate the presence of clinically significant PTSD symptoms, associate with risk fo...

  5. Cardiovascular biomarkers in clinical studies of type 2 diabetes

    DEFF Research Database (Denmark)

    Baldassarre, M P A; Andersen, A; Consoli, A

    2018-01-01

    biomarkers and 3) novel biomarkers (oxidative stress and endothelial dysfunction biomarkers). Within each category we present the currently best validated biomarkers with special focus on the population of interest (type 2 diabetes). For each individual biomarker, the physiological role, the validation...

  6. Caracterización clínico epidemiológica del parasitismo intestinal en pacientes jóvenes

    OpenAIRE

    Ayrelis Perovani Argüelles; Junior Vega Jiménez; Sandy Rodríguez Reyes; Yailín Cabrera Hernández

    2017-01-01

    Introducción: entre las enfermedades infecciosas, las producidas por parásitos intestinales constituyen un importante problema de salud para el hombre. Objetivo: caracterizar clínica y epidemiológicamente el parasitismo intestinal en pacientes jóvenes. Métodos: se realizó un estudio observacional, descriptivo y transversal en la consulta externa del Hospital Militar Docente "Dr. Mario Muñoz Monroy"; el universo de estudio estuvo representado por todos los pacientes jóvenesa tendidos dur...

  7. Sistema automatizado para la vigilancia epidemiológica de la tuberculosis en la atención primaria en Cuba

    OpenAIRE

    Machín Gelabert, Anabel; González Ochoa, Edilberto; Armas Pérez, Luisa

    1995-01-01

    Se describe un paquete de programas para microcomputadoras con el objetivo de automatizar el Sistema de Vigilancia Epidemiológica de la Tuberculosis el cual permite almacenar, validar y procesar información para llevar un control más exacto de la Notificación y el Registro de Casos, así como del Control de Focos. Brinda facilidades para la actualización y búsqueda de la información y permite la edición de un conjunto de salidas para su posterior análisis y toma de decisiones.

  8. Adicción a internet: Perfil clínico y epidemiológico de pacientes hospitalizados en un instituto nacional de salud mental

    OpenAIRE

    Lizardo CRUZADO DÍAZ; Luis MATOS RETAMOZO; Rommy KENDALL FOLMER

    2006-01-01

    Objetivo: Conocer las características clínicas y epidemiológicas de los pacientes hospitalizados con diagnóstico de "adicción a internet" en el Instituto Nacional de Salud Mental Honorio Delgado - Hideyo Noguchi desde la apertura del servicio de hospitalización el año 2001 hasta febrero del 2006. Material y Métodos: Estudio descriptivo, retrospectivo y trasversal: se revisaron las historias clínicas de 30 pacientes con el diagnóstico de "adicción a internet" y se les sometió a una breve encue...

  9. Panorama epidemiológico de exposición a plaguicidas inhibidores de colinesterasa en 17 departamentos del país

    OpenAIRE

    Marcela Varona; Ligia Morales; Jaime Ortíz; José F. Sánchez; Omayda Cárdenas; Fernando de la Hoz

    1998-01-01

    Los organofosforados y carbamatos son los responsables de la mayor parte de intoxicaciones por plaguicidas que se presentan en el país; son potentes inhibidores de la enzima acetilcolinesterasa, causando graves intoxicaciones agudas de tipo laboral como también efectos a largo plazo. Ante esta problemática, en 1982, el lnstituto Nacional de Salud (INS), a través del Laboratorio de Salud Ambiental creó el Programa de Vigilancia Epidemiológica de plaguicidas organofosforados y carbamatos (VEO),...

  10. Pressão arterial e discriminação interpessoal: revisão sistemática de estudos epidemiológicos

    OpenAIRE

    Couto,Paulo Francisco; Goto,Janaina Brugnera; Bastos,João Luiz

    2012-01-01

    A relação entre pressão arterial e discriminação tem sido investigada recentemente, havendo intensos debates na literatura sobre o tema. Este trabalho objetivou atualizar as revisões de literatura sobre discriminação e pressão arterial ou hipertensão. Foi conduzida pesquisa no PubMed, entre janeiro/2000 e dezembro/2010, incluindo estudos epidemiológicos, que avaliaram a discriminação interpessoal e sua relação com pressão arterial/hipertensão. Os 22 estudos identificados originaram-se dos Est...

  11. Impacto de la Globalización Neoliberal en Sudamérica desde la perspectiva de la Transición Epidemiológica

    OpenAIRE

    Justich Zabala, Pablo Ricardo

    2010-01-01

    Esta tesis estudia la relación experimentada entre la Globalización Neoliberal en Sudamérica y la mortalidad por grupos de edad y causa, clasificados según la teoría de la transición epidemiológica. Se han estudiado 4 países sudamericanos (Argentina, Brasil, Chile y Venezuela). Se demuestra que la Globalización Neoliberal no experimenta las mejoras esperables en términos de reducción de mortalidad por causas prevenibles, presentando en muchos casos efectos negativos sobre la reducción de las ...

  12. Toxoplasmosis congénita: aspectos clínicos y epidemiológicos de la infección durante el embarazo

    OpenAIRE

    Fernando Rosso; Alejandro Agudelo; Ángela Isaza; José Gilberto Montoya

    2007-01-01

    Se presenta una revisión actualizada sobre la toxoplasmosis durante el embarazo y de su consecuencia la toxoplasmosis congénita. Se pretende ilustrar a los profesionales de la salud con los diferentes aspectos tanto epidemiológicos como clínicos concernientes a esta enfermedad. Se revisan conceptos actuales de la parasitología y de la epidemiología de la transmisión materno-fetal, así como la presentación clínica de la infección perinatal. Se discuten nuevos adelantos en el diagnóstico y su i...

  13. Estudo clínico epidemiológico de quistos e tumores odontogénicos numa população hospitalar

    OpenAIRE

    Santiago, Ana Catarina de Almeida

    2014-01-01

    Os quistos e tumores maxilares, em particular os odontogénicos, representam um conjunto de patologias que surgem na cavidade oral sob variadas manifestações clinicas e imagiológicas. Podem conduzir a graves sequelas, desde deformações faciais até transformação maligna. O estudo retrospetivo realizado estudou as características clinico epidemiológicas dos Quistos e Tumores Odontogénicos e o impacto dos queratoquistos nos Tumores Odontogénicos, segundo a classificação da OMS de 2005. Selecionar...

  14. Transición epidemiológica-nutricional y cambios demográficos en la España contemporánea

    OpenAIRE

    Trescastro-López, Eva María; Galiana-Sánchez, María Eugenia; Bernabeu-Mestre, Josep

    2016-01-01

    Durante la segunda mitad del siglo XX la sociedad española completaba su transición demográfica, epidemiológica y sanitaria, y se alcanzaban los mejores indicadores de salud y bienestar de su historia. Sin embargo, este proceso ha venido acompañado de nuevos retos como el envejecimiento poblacional y la elevada prevalencia de patologías crónicas no transmisibles. En este artículo se analiza la relación entre alimentación, nutrición y salud, y se reflexiona sobre el papel que puede jugar la me...

  15. Aspectos entomológicos e epidemiológicos das epidemias de dengue em Fortaleza, Ceará, 2001-2012

    OpenAIRE

    Oliveira, Rhaquel de Morais Alves Barbosa; Araújo, Fernanda Montenegro de Carvalho; Cavalcanti, Luciano Pamplona de Góes

    2018-01-01

    Resumo Objetivo: descrever os aspectos entomológicos e epidemiológicos das epidemias de dengue ocorridas em Fortaleza, Ceará, Brasil, de 2001 a 2012. Métodos: estudo descritivo com dados dos Sistemas de Informação de Agravos de Notificação (Sinan), de Informações Hospitalares (SIH), do Programa de Febre Amarela e Dengue (2001-2009), do Programa Nacional de Controle da Dengue (2010-2012) e Levantamento Rápido do Índice de Infestação de Aedes aegypti, referentes aos anos quando a incidência...

  16. Evaluación de los factores epidemiológicos como predictores de los resultados postquirúrgicos en patología lumbar degenerativa

    OpenAIRE

    Lozano Álvarez, Carlos

    2011-01-01

    Els resultats del tractament quirúrgic per dolor lumbar crònic i patologia degenerativa lumbar, patologies d'elevada prevalença i despesa sanitària, estan afectats per múltiples factors. En aquest treball hem estudiat com les característiques epidemiològiques dels pacients de la nostra població influeixen sobre el canvi de la qualitat de vida, la discapacitat i el dolor després de cirurgies per patologia lumbar degenerativa. Del nostre estudi, d'acord amb la revisió realitzada de la literatur...

  17. Características clínico-epidemiológicas de pacientes con cólera en la ciudad de México

    OpenAIRE

    Vilchis-Guizar Agustina Elena; Uribe-Márquez Samuel; Pérez-Sánchez Patricia Leonor

    1999-01-01

    OBJETIVO: Comparar las características clínico-epidemiológicas de enfermos de cólera (casos) con las de pacientes con diarrea por otra causa (no casos), atendidos en las unidades médicas de la Delegación 2 Noreste del Distrito Federal, del Instituto Mexicano del Seguro Social (IMSS). MATERIAL Y MÉTODOS: Se realizó un estudio transversal analítico y se utilizaron datos de 4 952 notificaciones reunidas entre 1995 y 1998 a través del formato oficial "Hoja de notificación inmediata de casos de có...

  18. Biomarker Development for TLR4 Agonists

    National Research Council Canada - National Science Library

    Persing, David H

    2004-01-01

    .... To monitor the effectiveness of immunoprophylaxis in human trials, it may become necessary to develop surrogate biomarkers of protection since experimental challenge endpoints are not readily available...

  19. Serum Antibody Biomarkers for ASD

    Science.gov (United States)

    2015-10-01

    typically developing control. US, unaffected sibling control. 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF PAGES 19a...typically developing (TD) children (e.g., Warren et al., 1990; Singh, 2009). The goal of this study is to identify a serum antibody biomarker for ASD using...50% less IgG1 antibody in ASD boys vs . TD boys (p=0.0096). The level of ASD1 binding to the AM group was the same as to the ASD boys. These data

  20. Perfil epidemiológico de pacientes com traumatismo raquimedular atendidos em hospital terciário

    Directory of Open Access Journals (Sweden)

    Dionei Freitas Morais

    2013-01-01

    Full Text Available OBJETIVO: Avaliar o perfil epidemiológico de pacientes com traumatismo raquimedular atendidos em hospital terciário. MÉTODOS: Estudo descritivo, transversal, prospectivo, com 321 pacientes vítimas de traumatismo raquimedular, realizado de janeiro de 2008 a junho de 2012. Foram estudadas as variáveis: sexo; idade; estado civil; profissão; escolaridade; religião; procedência; etiologia, morfologia e região da lesão; condição neurológica pela escala da ASIA e lesões associadas. RESULTADOS: Amostra constituída por 72% pacientes do sexo masculino e 28% do feminino, prevalência da faixa etária de 21 a 30 anos. Os estados civis mais frequentes foram união estável (46,8% e solteiros (41,7%. O nível de escolaridade foi ensino fundamental incompleto (57% e completo (17,8%. As causas mais frequentes foram acidentes automobilísticos (38,9% e queda (27,4%. A lesão mais presente foi fratura explosão (23,7%, as regiões mais afetadas foram cervical subaxial (41,7% e transição toracolombar (30,5%. A lesão associada mais frequente foi traumatismo cranioencefálico (TCE (28,2%. O estado neurológico mais observado na internação/alta foi ASIA-E. Ocorreram 25 óbitos (7,8%, sendo que 76% com lesão na região cervical foram estratificados com ASIA-A, e 68% tiveram complicações respiratórias. CONCLUSÃO: O trauma raquimedular acometeu mais adultos jovens do sexo masculino com união estável e baixo nível de escolaridade. A causa mais frequente foi acidente automobilístico, o tipo de lesão foi fratura explosão e a região cervical a mais acometida. A condição neurológica mais presente foi ASIA-E, o TCE foi a lesão associada mais frequente e a maior gravidade pela classificação da ASIA nos casos de envolvimento cervical aumentou o risco de complicações respiratórias e morbidade e mortalidade.

  1. Aspectos epidemiológicos relacionados con la lactancia materna durante el primer año de vida

    Directory of Open Access Journals (Sweden)

    Orlando Díaz Tabares

    2002-06-01

    Full Text Available Se realizó un estudio transversal para determinar el comportamiento de algunas variables epidemiológicas relacionadas con la lactancia materna durante el primer año de vida, y se tomaron como muestra las 24 madres que viven en el área del Consejo Popular número 2 de San Cristóbal, que parieron en los meses de enero, febrero y marzo del año 2000, las cuales fueron encuestadas al cumplir el año de parida. Se encontró una duración media de la lactancia materna exclusiva equivalente a 77 días, y de la lactancia materna en general de 137. Se comprobó riesgo relativo para el destete antes del cuarto mes de parida los casos de uso de tetes y biberones y exposición al estrés. Predominó la infección del tracto urinario, seguida por la enfermedad diarreica aguda (EDA entre los niños que enfermaron, y la mayor protección de la lactancia materna exclusiva se observó para la EDA.A crosswise study was carried out to determine the performance of some epidemiological variables related to breast feeding during the first year of life of the newborn and the sample was composed by 24 mothers who live in an area of People´s council No. 2 of San Cristobal, gave birth in January, February and March, 2000 and were surveyed one year after their deliveries. . The average length of exclusive breast-feeding was 77 days and of general breast feeding was 137 days. Relative risks were demonstrated for weaning before the fourth month of life in cases using pacifiers and feeding bottles and exposed to stress. Urinary tract infection prevailed, followed by acute diarrhea among sick infants and the greatest protection of the exclusive breast feeding was provided for acute diarrhea.

  2. Abortamento na adolescência: um estudo epidemiológico Abortion and miscarriage in adolescence: an epidemiological study

    Directory of Open Access Journals (Sweden)

    Leila Maria Vieira

    2007-10-01

    Full Text Available O presente trabalho foi desenvolvido no Hospital Maternidade Santa Izabel da cidade de Bauru, São Paulo, Brasil, e teve como objetivo investigar o abortamento na adolescência e compará-lo com o das mulheres adultas. Os indicadores buscaram traçar o perfil epidemiológico das mulheres internadas, por meio de dados coletados em prontuários, entre aquelas com diagnóstico de aborto, independente da forma clínica, entre os anos de 2000 a 2003. O total de abortamentos registrados foi de 2.286, sendo 459 (20,08% na faixa etária da adolescência e a forma completa foi significativamente maior nas adolescentes quando comparada às das mulheres adultas; segundo o ano de análise, constatou-se decréscimo de ocorrência entre as adolescentes, com maior incidência em 2000 (30,50%, seguida dos anos de 2001 (25,05%, 2002 (23,53% e 2003 (20,92%, sendo que as adolescentes apresentaram tendência a permanecer dois ou mais dias hospitalizadas. Enfatiza-se a implementação de políticas e programas direcionados à saúde sexual e reprodutiva e suas co-morbidades.This study was conducted at the Santa Izabel Maternity Hospital in the town of Bauru, São Paulo State, Brazil, in order to investigate abortions and miscarriages in adolescence, comparing them to terminations among adult women. The indicators are used to draw up an epidemiological profile of hospitalized women through data collected from documents on women with diagnoses of abortion or miscarriage from 2000 to 2003, regardless of their clinical form. The total number of registered early terminations of pregnancy reached 2,286, with 459 (20.08% during adolescence, with the complete form being significantly higher among teenagers than adults; a decrease in the occurrence among adolescents was noted, dropping from 30.5% in 2000 to 25.05% in 2001, 23.53% in 2002 and 20.92% in 2003; with adolescents tending to remain in hospital for two or more days. The implementation is stressed of policies and

  3. Desempenho do programa BABSIM no estudo epidemiológico de Boophilus microplus (Canestrini, 1889 (Acari: Ixodidae

    Directory of Open Access Journals (Sweden)

    Fonseca A.H.

    2000-01-01

    Full Text Available Os modelos de simulação são ferramentas úteis na análise das inter-relações bioecológicas dos carrapatos. Partindo dessa premissa, objetivou-se avaliar o desempenho do programa BABSIM como auxiliar no estudo epidemiológico de B. microplus para o Estado de Minas Gerais, validando-se os ajustes no programa pela análise comparativa das curvas populacionais observadas e simuladas em Pedro Leopoldo e São Miguel do Anta, MG. As simulações foram realizadas com o programa BABSIM utilizando-se os parâmetros biológicos originais do programa e com ajustes nas temperaturas mínimas para oviposição e incubação dos ovos, no índice de encontro do hospedeiro pelas larvas, e no índice de sobrevivência dos estádios de vida livre. Os ajustes nos parâmetros biológicos propiciaram aumento na intensidade da carga parasitária, porém não foram suficientes para representar com maior precisão a dinâmica populacional no ecossistema em São Miguel do Anta. As simulações procedidas com os parâmetros biológicos originais e ajustados apresentaram comportamento variável para os diferentes anos em relação aos observados no estudo experimental de Pedro Leopoldo. Apesar de os resultados das simulações terem contribuído para a análise do conjunto de variáveis que interagem para determinar as variações do tamanho das populações de carrapatos nos ecossistemas estudados, eles indicaram, também, a necessidade de introduzir modificações nos submodelos que representam as inter-relações parasito-ambiente antrópico, assim como a necessidade de modificar o programa para permitir alterações de manejo dos animais, dentro de um mesmo ano de simulação, e, dessa maneira, justificar com maior precisão a dinâmica populacional em diferentes tipos de ecossistemas.

  4. La uveítis, comportamiento clínico epidemiológico en Pinar del Río

    Directory of Open Access Journals (Sweden)

    Barbara Taysel Naranjo Valladares

    2015-04-01

    Full Text Available Introducción: la uveítis es la forma principal de inflamación ocular y puede estar asociada a diferentes etiologías. Constituyen una causa de deterioro visual y de ceguera. Objetivos: determinar el comportamiento clínico-epidemiológico de la uveítis en Pinar del Río. Material y método: se realizó una investigación longitudinal, prospectiva, aplicada y descriptiva en los pacientes, que acudieron a consulta de Uveítis del Hospital General Abel Santamaría Cuadrado, de la Provincia Pinar del Río, durante el período de abril-septiembre de 2014. El universo estuvo constituido por la totalidad de pacientes que acudieron a consulta, a los que se les diagnóstico uveítis (58, coincidiendo esta con la muestra. Para el análisis y elaboración de los datos obtenidos, se resumieron en cuadros estadísticos. El procesamiento estadístico fue mediante técnicas de estadística descriptiva, utilizando el sistema Epi Info y los resultados se muestran en tablas y figuras, utilizando el método porcentual. Resultados: predominaron los pacientes en las edades comprendidas entre los 31 y 50 años de edad, con ligero predominio del sexo masculino, color de la piel blanca, en la población rural. Fue más frecuente la uveítis anterior, de forma aguda, con resolución del cuadro en menos de 3 meses. Predominó la forma no granulomatosa, unilateral, idiopática. Las principales complicaciones asociadas al proceso inflamatorio fueron: la hipertensión ocular y las sinequias posteriores. Conclusiones: valorar adecuadamente las manifestaciones clínicas y complicaciones que acompañan la uveítis permiten realizar un diagnóstico y tratamiento correcto de esta peculiar enfermedad ocular.

  5. Aspectos epidemiológicos relacionados con el tipo de lactancia durante el primer año de vida

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    Orlando Díaz Tabares

    2001-08-01

    Full Text Available Resumen Se realizó un estudio descriptivo con 101 niños nacidos en 1998, para determinar la relación de algunas variables epidemiológicas, con el tipo de lactancia que reciben hasta el año de edad en el área de salud de San Cristóbal. Las variables se precisaron entrevistando a las madres cuando cumplieron el año de parida. Se comprobó que la práctica de la lactancia materna exclusiva y complementada es baja. Las desviaciones en el estado nutricional estuvieron relacionadas con el abandono de la lactancia materna de manera significativa. La infección respiratoria alta aguda (IRAA fue la entidad más padecida por los lactantes, presentándose incluso cuando el niño recibía lactancia materna exclusiva. La hipogalactia o la agalactia fue el motivo predominante para destetar. El 32,6 % de las madres dijo no haber sido informada sobre el tema, y entre las que sí lo fueron, refirieron al consultorio como el lugar de mayor participación.Summary A descriptive study was conducted with 101 children that were born in 1998 to determine the relation of some epidemiological variables with the type of breast feeding they receive up to the first year of life in the health area of San Cristóbal. The variables were determined by interviewing their mothers a year after delivery. It was proved that the practice of exclusive and complemented breast feeding is low. The deviations in the nutritional state were related to the significant abandonment of breast feeding. The acute upper respiratory infection (AURI was the most common entity among infants. It was observed even when the child recieved exclusive breast feeding. Hypogalactia or agalactia were the main causes of weaning. 32.6 % of the mothers said that they had not been informed about the topic and, among those who had, they referred to the family physician’s office as the place of highest participation.

  6. Caracterización clínico-epidemiológica y de laboratorio del Síndrome de West.

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    Marcelino Lizano Rabelo

    2009-06-01

    Full Text Available Se describe un grupo de características clínico-epidemiológicas y de laboratorio relacionadas con esta enfermedad. Se realizó un estudio descriptivo de 39 pacientes con diagnóstico definitivo al egreso de Síndrome de West, pertenecientes al Hospital Pediátrico Docente Provincial “José Martí Pérez “ de Sancti Spíritus (enero 1999- diciembre 2008, se emplearon para el diagnóstico los criterios establecidos por la Liga Internacional Contra la Epilepsia (ILAE 2001, las variables del estudio fueron: Edad de debut, sexo, etiología, manifestaciones clínicas, resultados de los complementarios realizados. El dato primario se tomó mediante un cuestionario que fue aplicado a las historias clínicas de estos pacientes. Los resultados fueron expresados en tablas y analizados de forma porcentual. La edad de debut de dicho Síndrome fue más frecuente a los 5 meses con 14 pacientes para un 35.90 % y el sexo masculino con 27 pacientes (69.23%. La etiología predominante fue la sintomática en 29 casos (74.35 %.Como sintomatología epiléptica los espasmos infantiles se presentaron en la totalidad de los niños estudiados, prevaleciendo el flexo-extensor encontrado en el 46.15% de los pacientes y como síntomas no epilépticos, el retardo en el desarrollo de las habilidades motoras en 36 casos (92.30 %. En el Electroencefalograma interictal de vigilia predominó la hipsarritmia típica con 30 casos (76.92 %. El comportamiento del Síndrome de West en nuestro medio es similar a lo descrito en la literatura, predominó el sexo masculino y la etiología sintomática, todos los casos presentaron hipsarritmia en el Electroencefalograma (EEG interictal.

  7. Estudio epidemiológico de la dermatitis atópica desde la farmacia comunitaria: Estudio DAFAC

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    Moreno P.

    2014-03-01

    Full Text Available Objetivos: Diseñar y evaluar la utilidad de un protocolo de actuación del farmacéutico comunitario ante las consultas realizadas sobre dermatitis atópica en la farmacia comunitaria, acordando con dermatólogos los criterios de derivación. Conocer los motivos de consulta más habituales y determinar en qué casos constituyen motivo de derivación al médico. Métodos: Estudio epidemiológico realizado en farmacias comunitarias españolas entre febrero del 2011 y enero del 2012. Se incluyeron en el estudio todos los usuarios de las farmacias que consultan un problema de salud dermatológico. Los farmacéuticos participantes, tras recibir formación específica online, aplicaron el protocolo de actuación consensuado. Se registraron los motivos de consulta, los casos de derivación al médico, la existencia de sobreinfecciones, el uso de productos adecuados para el cuidado de la piel. Resultados/Discusión: Participaron 259 farmacéuticos de 15 comunidades autónomas que registraron 688 intervenciones válidas. La distribución por sexo de los pacientes corresponde a 354 (51,5 % de sexo masculino y 334 (48,5 % del femenino, con mayor incidencia de la patología en menores de 14 años. En el 70% de los casos no se requirió la derivación al dermatólogo. Motivos de consulta: prurito, irritación, dificultad para dormir, ansiedad y estrés, y sobreinfección (35%, principal causa de derivación. La elaboración y difusión del protocolo y criterios de derivación, así como los resultados del estudio a los socios de SEFAC (Sociedad Española de Farmacia Comunitaria y al resto de farmacéuticos comunitarios permitirán la resolución de muchos de los casos de dermatitis atópica, contribuyendo así a la mejora de la calidad de vida del paciente.

  8. Mumps meningoencephalitis: an epidemiological approach Meningoencefalite pelo vírus da caxumba: abordagem epidemiológica

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    Alfredo Leboreiro-Fernandez

    1997-01-01

    Full Text Available The aim of this study was to analyse distribution of meningoencefalitis caused by mumps viras in children related to sex, age and seasonal influences. Thirty seven children were evaluated, ages ranging from 2 to 14 years. They were seen at Emergency Unit of Faculdade de Medicina do Triângulo Mineiro and at Hospital da Criança, in Uberaba-MG, Brazil, from March 1st 1991 to February 1st 1993 and they were hospitalized for about 5 days. Through a protocol findings were studied during hospitalization and clinical course stressing epidemiology, symptomatology, cerebrospinal fluid studies, electroencephalogram and cortical function analysis. Only epidemiological data were considered in the present study. Data analysis revealed male predominance, at a range from 5 to 9 years and great number of occurrences at the last quarter of the year.O presente trabalho tem por objetivo, estudar a distribuição quanto ao sexo, idade e sazonalidade, em crianças com meningencefalite pelo vírus da caxumba. Foram avaliadas 37 crianças, com idades variando de 2 a 14 anos, atendidas no Pronto-Socorro do Hospital Escola da FMTM e do Hospital da Criança, MG, no período de 1-março-1991 a 1-fevereiro-1993 e hospitalizadas por período médio de 5 dias. Através de protocolo pré-elaborado foram estudados os achados obtidos por ocasião da internação e evolução, enfatizando-se a epidemiologia, sintomatologia, líquido cefalorraqueano, eletrencefalograma e função cortical. São considerados apenas os dados epidemiológicos, no presente estudo. A análise das informações pertinentes revela predomínio no sexo masculino, na faixa etária dos 5 aos 9 anos e maior número de casos no último trimestre do ano, correspondente à estação da primavera.

  9. Comportamiento de la vigilancia epidemiológica de la leptospirosis humana en Colombia, 2007-2011

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    Solmara Bello

    2013-08-01

    Full Text Available Introducción. La leptospirosis es una zoonosis reemergente de distribución mundial causada por una espiroqueta del género Leptospira. Durante los últimos años en Colombia aumentó el número de casos en humanos y animales. Objetivo. Caracterizar epidemiológicamente los casos de leptospirosis notificados al Sistema Nacional de Vigilancia en Salud Pública de Colombia y hacer una aproximación para conocer los serogrupos que circulan en el país. Materiales y métodos. Se diseñó un estudio observacional de corte retrospectivo, con registros del proceso de vigilancia de los casos reportados por el software Sivigila y muestras enviadas al Grupo de Microbiología de la Red Nacional de Laboratorios, durante el periodo 2007 a 2011. Se registraron variables de tipo sociodemográficas y se analizaron 17 serogrupos de Leptospira. En el análisis seutilizaron medidas de frecuencia, tendencia central y dispersión. Resultados. Se procesaron 11.786 registros, confirmándose 4.621 casos de leptospirosis. Las entidades territoriales con mayor registro fueron Valle del Cauca, Antioquia, Risaralda, Atlántico y Barranquilla; y las de incidencia más alta fueron Guaviare, Risaralda, San Andrés, Santa Marta y Barranquilla. El mayor número de casos reportados perteneció al área urbana, con mayor frecuencia de hombres (77 %, estudiantes (19,4 % y amas de casas (13,6 %, con una mediana por edad de 29 años (rango intercuartílico: 45-19. Se evidenció la circulación de 17 serogrupos en el país; los más frecuentes fueron Australis (24,89 %, Hebdomadis (9,33 % y Sejroe (8,0 %. Conclusión. En Colombia se ha mejorado la notificación y clasificación final de los casos, lo que ha permitido identificar al serogrupo Australis como el de mayor circulación.   doi: http://dx.doi.org/10.7705/biomedica.v33i0.1608

  10. Aspectos epidemiológicos da tuberculose em crianças e adolescentes no Rio de Janeiro

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    Thaise Pereira Matos

    2012-08-01

    Full Text Available OBJETIVO: Descrever os aspectos epidemiológicos da tuberculose infantil (TB em hospital de referência. MÉTODOS: Estudo retrospectivo (1999-2008 de 473 indivíduos (0-14 anos com TB confirmada, ou com melhora clínica até o quarto mês de tratamento sob os cuidados da unidade, incluindo a revisão dos prontuários médicos, fichas de acompanhamento clínico de TB e fichas de notificação da unidade de TB do hospital. RESULTADOS: Dentre os 473 casos de TB incluídos no estudo, 52% apresentou reatividade à prova tuberculínica, 66% história de contato com paciente com tuberculose pulmonar, principalmente intradomiciliar, sendo o pai/padrasto o familiar mais envolvido; TB disseminada em 22%. O resultado do teste de HIV foi obtido em 265 casos (56%, sendo positivo em 45 (17%. O diagnóstico de TB foi confirmado em 31% dos casos, mais frequentemente em crianças com idade acima de 5 anos, com prova tuberculínica negativa, e nas formas disseminadas. Das 65 culturas positivas para a TB realizadas no estudo, o teste da sensibilidade às drogas anti-TB foi obtido em 30 casos (46%, entre os quais 10 (33% eram resistentes a um ou mais fármacos anti-TB, e 2 (0,8% eram multirresistentes. Entre os pacientes com tuberculose pulmonar confirmada, 31% não preencheram os critérios para iniciar o tratamento com anti-TB de acordo com pontuação do Ministério da Saúde (< 25 pontos. CONCLUSÃO: A elevada percentagem de TB resistente à fármacos e a co-infecção com HIV identificados neste estudo enfatiza a necessidade de realizar estudos adicionais para avaliar tal impacto nas atividades de controle da TB infantil.

  11. Caracterización epidemiológica de la descompensación aguda del asma bronquial

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    Yanin Arteaga Prado

    2013-08-01

    Full Text Available Introducción: el asma bronquial tiene una compleja fisiopatología que involucra la presencia en el paciente de factores genéticos de atopia, mecanismos inmunológicos disfuncionales. Objetivo: caracterizar la asociación de diversos aspectos epidemiológicos con la aparición de descompensaciones agudas del asma bronquial. Material y método: se realizó un estudio descriptivo y transversal a 118 pacientes del área de dos consultorios médicos del Policlínico Universitario "Hermanos Cruz" de la Ciudad de Pinar del Río durante el primer trimestre del 2012. Se comparó el grupo de pacientes que presentaron descompensaciones de la enfermedad con el grupo de pacientes que no se descompensó. Se aplicó un cuestionario para explorar las variables de interés. Para verificar la asociación entre variables se utilizó el estadígrafo ji cuadrado para un valor de significación estadística á=0.05. Resultados: las descompensaciones agudas fueron casi dos veces más frecuentes en el sexo femenino. De manera muy significativa (Z=3,26 p<0,01 una tercera parte de los asmáticos de su enfermedad; las amas de casa y los estudiantes fueron los más afectados. Solo el 38,1 % de los asmáticos tuvo un adecuado seguimiento por un especialista (clínico, pediatra, alergólogo o inmunólogo y de estos solo el 11,1 % presentaron descompensaciones agudas, en tanto se descompensó un 39,7 % de los que no tienen seguimiento especializado. Conclusiones: la degradación de las condiciones de la vivienda favoreció la aparición de descompensaciones agudas del asma. En tres cuartas partes de las casas había animales domésticos, existiendo una fuerte asociación entre esta condición y la aparición de descompensaciones agudas del paciente asmático.

  12. Aspectos epidemiológicos dateníase-cisticercose na área endêmica de Lagamar, MG

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    Mario León Silva-Vergara

    1995-12-01

    Full Text Available Um inquérito epidemiológico sobre teníase-cisticercose foi realizado em Lagamar- MG em 1992. Cadastradas 1109 casas com 3344 habitantes. O inquérito abrangeu 875 (86% famílias e foi respondido por um informante que, em 80% dos casos, foi o pai. Na cidade havia 100 chiqueiros em 100 (11,4% casas que albergavam 406 suínos, em condições extremamente precárias. Em 300 (34,2% casas havia o antecedente de teníase em algum membro da família. O antecedente de convulsão foi relatado por 125 (14,2% famílias. O início das convulsões na idade adulta foi caracterizado em 39 (3 7,8% famílias e o antecedente de doenças mentais foi relatado em 53 (6% casas. Os exames parasitológicos de fezes mostraram ovos de Taenia spp em 24 (1,3% das 1850 amostras examinadas.An epidemiological inquiry of human- cysticercosis due to Taenia solium was carried out in Lagamar, Minas Gerais State, Brazil, in 1992. A survey of 1109 houses with 3344. inhabitants was made. The inquiry included 875 (86% families and the questionaire was answered by an informer, who was the father in 80% of the cases. One hmidred pigsties, sheltering 406 swines in extremely precarious conditions, were found in 100 (11.4% houses. A history on taeniasis in some member of the family was verified in 300 (34.2% houses. A histoiy of seizures was referred to by 125 (14.2% of families. The outset of convulsion in adult age was characterized in 39 (37.8% families. A history of mental disorder was reported in 53 (6.0% of houses. Stool examinations were positive for Taenia spp in 24 (1.3% of samples examined.

  13. Proteomic Biomarkers for Spontaneous Preterm Birth

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    Kacerovsky, Marian; Lenco, Juraj; Musilova, Ivana

    2014-01-01

    This review aimed to identify, synthesize, and analyze the findings of studies on proteomic biomarkers for spontaneous preterm birth (PTB). Three electronic databases (Medline, Embase, and Scopus) were searched for studies in any language reporting the use of proteomic biomarkers for PTB published...

  14. Biomarkers of Renal Function : Towards Clinical Actionability

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    Binnenmars, S Heleen; Hijmans, R S; Navis, G; de Borst, M H

    This review provides an overview of the clinical value of themost relevant renal biomarkers, focusing on two main clinical conditions: acute kidney injury and chronic kidney disease. We categorize biomarkers according to their actionability, in terms of a documented response to treatment in relation

  15. MicroRNA biomarkers in glioblastoma

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    Hermansen, Simon Kjær; Kristensen, Bjarne Winther

    2013-01-01

    tissues. Understanding these alterations is key to developing new biomarkers and intelligent treatment strategies. This review presents an overview of current knowledge about miRNA alterations in glioblastoma while focusing on the clinical future of miRNAs as biomarkers and discussing the strengths...

  16. Stable isotopes and biomarkers in microbial ecology

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    Boschker, H.T.S.; Middelburg, J.J.

    2002-01-01

    The use of biomarkers in combination with stable isotope analysis is a new approach in microbial ecology and a number of papers on a variety of subjects have appeared. We will first discuss the techniques for analysing stable isotopes in biomarkers, primarily gas chromatography-combustion-isotope

  17. DNA Methylation Biomarkers: Cancer and Beyond

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    Thomas Mikeska

    2014-09-01

    Full Text Available Biomarkers are naturally-occurring characteristics by which a particular pathological process or disease can be identified or monitored. They can reflect past environmental exposures, predict disease onset or course, or determine a patient’s response to therapy. Epigenetic changes are such characteristics, with most epigenetic biomarkers discovered to date based on the epigenetic mark of DNA methylation. Many tissue types are suitable for the discovery of DNA methylation biomarkers including cell-based samples such as blood and tumor material and cell-free DNA samples such as plasma. DNA methylation biomarkers with diagnostic, prognostic and predictive power are already in clinical trials or in a clinical setting for cancer. Outside cancer, strong evidence that complex disease originates in early life is opening up exciting new avenues for the detection of DNA methylation biomarkers for adverse early life environment and for estimation of future disease risk. However, there are a number of limitations to overcome before such biomarkers reach the clinic. Nevertheless, DNA methylation biomarkers have great potential to contribute to personalized medicine throughout life. We review the current state of play for DNA methylation biomarkers, discuss the barriers that must be crossed on the way to implementation in a clinical setting, and predict their future use for human disease.

  18. Bias in emerging biomarkers for bipolar disorder

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    Carvalho, A F; Köhler, C A; Fernandes, B S

    2016-01-01

    BACKGROUND: To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. METHOD: The Pubmed/Medline, E...

  19. Imaging biomarker roadmap for cancer studies

    NARCIS (Netherlands)

    O'Connor, James P. B.; Aboagye, Eric O.; Adams, Judith E.; Aerts, Hugo J. W. L.; Barrington, Sally F.; Beer, Ambros J.; Boellaard, Ronald; Bohndiek, Sarah E.; Brady, Michael; Brown, Gina; Buckley, David L.; Chenevert, Thomas L.; Clarke, Laurence P.; Collette, Sandra; Cook, Gary J.; Desouza, Nandita M.; Dickson, John C.; Dive, Caroline; Evelhoch, Jeffrey L.; Faivre-Finn, Corinne; Gallagher, Ferdia A.; Gilbert, Fiona J.; Gillies, Robert J.; Goh, Vicky; Griffiths, J. R.; Groves, Ashley M.; Halligan, Steve; Harris, Adrian L.; Hawkes, David J.; Hoekstra, Otto S.; Huang, Erich P.; Hutton, Brian F.; Jackson, Edward F.; Jayson, Gordon C.; Jones, Andrew; Koh, Dow-Mu; Lacombe, Denis; Lambin, Philippe; Lassau, Nathalie; Leach, Martin O.; Lee, Ting-Yim; Leen, Edward L.; Lewis, Jason S.; Liu, Yan; Lythgoe, Mark F.; Manoharan, Prakash; Maxwell, Ross J.; Miles, Kenneth A.; Morgan, Bruno; Morris, Steve; Ng, Tony; Padhani, Anwar R.; Parker, Geoff J. M.; Partridge, Mike; Pathak, Arvind P.; Peet, Andrew C.; Punwani, Shonit; Reynolds, Andrew R.; Robinson, Simon P.; Shankar, Lalitha K.; Sharma, Ricky A.; Soloviev, Dmitry; Stroobants, Sigrid G.; Sullivan, Daniel C.; Taylor, Stuart A.; Tofts, Paul S.; Tozer, Gillian M.; van Herk, Marcel B.; Walker-Samuel, Simon; Wason, James; Williams, Kaye J.; Workman, Paul; Yankeelov, Thomas E.; Brindle, Kevin M.; McShane, Lisa M.; Jackson, Alan; Waterton, John C.

    Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and

  20. Implementation of proteomic biomarkers : Making it work

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    Mischak, Harald; Ioannidis, John P. A.; Argiles, Angel; Attwood, Teresa K.; Bongcam-Rudloff, Erik; Broenstrup, Mark; Charonis, Aristidis; Chrousos, George P.; Delles, Christian; Dominiczak, Anna; Dylag, Tomasz; Ehrich, Jochen; Egido, Jesus; Findeisen, Peter; Jankowski, Joachim; Johnson, Robert W.; Julien, Bruce A.; Lankisch, Tim; Leung, Hing Y.; Maahs, David; Magni, Fulvio; Manns, Michael P.; Manolis, Efthymios; Mayer, Gert; Navis, Gerarda; Novak, Jan; Ortiz, Alberto; Persson, Frederik; Peter, Karlheinz; Riese, Hans H.; Rossing, Peter; Sattar, Naveed; Spasovski, Goce; Thongboonkerd, Visith; Vanholder, Raymond; Schanstra, Joost P.; Vlahou, Antonia

    Eur J Clin Invest 2012; 42 (9): 10271036 Abstract While large numbers of proteomic biomarkers have been described, they are generally not implemented in medical practice. We have investigated the reasons for this shortcoming, focusing on hurdles downstream of biomarker verification, and describe

  1. Variables epidemiológicas y clínicas de la sífilis reciente en el Policlínico "Héroes del Moncada"

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    Rubén José Larrondo Muguercia

    1997-06-01

    Full Text Available Se realizó un estudio descriptivo que incluyó características clínicas y variables epidemiológicas de todos los pacientes con diagnóstico de sífilis reciente en el Policlínico Comunitario Docente "Héroes del Moncada", en el quinquenio de 1990 a 1994. La forma clínica de presentación más frecuente fue la de sífilis reciente adquirida sintomática (58,93 %. Se encontró significación estadística entre el hecho de padecer sífilis reciente adquirida sintomática y el grupo de edad comprendido entre 20 y 24 años. Los índices de productividad de la entrevista epidemiológica se comportaron de forma satisfactoria.A descriptive study including clinical characteristics and epidemiological variables of all patients with recent diagnosis of syphilis at the "Heroes del Moncada" Community Teaching Polyclinic between 1990 and 1994 was conducted. The most frequent clinical form of presentation was that of recently acquired symptomatic syphilis.(58.93%. A statistical signification was found between the fact of suffering from recently acquired symptomatic syphilis and the age group from 20 to 24 years. The productivity indexes of the epidemiological interview were satisfactory.

  2. Modelos alternativos para el análisis epidemiológico de la obesidad como problema de salud pública

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    Parra-Cabrera Socorro

    1999-01-01

    Full Text Available Los problemas de salud pública han sido estudiados desde muy diversas perspectivas y utilizando diferentes modelos teóricos y metodológicos. Dos modelos que han sido frecuentemente utilizados son el modelo epidemiológico clásico y el modelo epidemiológico social. Estos modelos emplean distintos criterios conceptuales, metodológicos e ideológicos. Se objetivó hacer una contrastación entre estos modelos de acuerdo a los criterios mencionados, utilizando el estudio de la obesidad como ejemplo de la utilización de estos modelos. Esta contrastación muestra que el conocimiento generado por cada modelo es muy distinto. Se discuten posibles áreas de complementariedad entre ambos modelos y la utilización de las ciencias sociales como estrategia para ampliar nuestro conocimiento sobre problemas de salud pública, en especial el problema de la obesidad.

  3. Lente de contato em crianças: aspectos epidemiológicos Contact lens in children: epidemiological aspects

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    André Luiz Alves Salame

    2008-06-01

    Full Text Available OBJETIVO: Traçar o perfil epidemiológico de crianças encaminhadas para adaptação de lente de contato. MÉTODOS: Foi realizado estudo retrospectivo de pacientes registrados no Setor de lente de contato da Universidade Federal de São Paulo. Os pacientes com até 12 anos de idade foram avaliados quanto ao sexo, idade, diagnóstico, indicação e tipo de lente de contato testada na primeira consulta. RESULTADOS: Dos 73 prontuários avaliados, 34 (46,6% pertenciam a crianças do sexo masculino e 39 (53,4% a crianças do sexo feminino. A idade variou de 2 a 12 com média de 10,2 e desvio-padrão de 2,42 anos. O diagnóstico mais encontrado foi afacia em 16 (21,9% crianças, seguido de ceratocone em 14 (19,1%, leucoma em 11 (15%, anisometropia em 10 (13,7%, ametropia em 9 (12,3%, astigmatismo irregular em 7 (9,5% e ectopia lentis em 4 (5,4%. Uma criança era alta míope (1,3% e outra emétrope (1,3% que possuía desejo de usar lente de contato estética. Em relação às indicações, 52 (71,2% pacientes tinham indicação médica, 9 (12,3% indicação óptica e 12 (16,4% indicação cosmética. Foram testadas lentes em 103 olhos sendo as mais testadas a rígida gás permeável esférica em 43 (41,7%, a gelatinosa esférica em 41 (39,8% e a gelatinosa cosmética em 11 (10,6%. CONCLUSÃO: O perfil epidemiológico dos usuários de lente de contato nessa faixa etária tem como diagnóstico mais prevalente a afacia, a indicação mais freqüente a de ordem médica e a lente mais testada a rígida gás permeável esférica.PURPOSE: To describe the epidemiology of children submitted to contact lens fit. METHODS: Retrospective study of 73 children that had been submitted to contact lens fit at the "Universidade Federal de São Paulo". This study analyzed sex distribution, age, diagnosis, indications and contact lens fitted at first examination. RESULTS: 34 children (46.6% were male and 39 (53.4% female, aged between 2 and 12 years with mean of 10.2 and

  4. Características epidemiológicas dos acidentes na infância Epidemiological characteristics of childhood accidents

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    Carmen Vieira de Sousa Unglert

    1987-06-01

    Full Text Available Foram estudadas as características epidemiológicas dos acidentes na infância, através da aplicação de questionário. Foram levantados os acidentes ocorridos num período de 2 anos em crianças de famílias que freqüentavam dois postos de assistência médica de bairros situados na periferia da cidade de São Paulo, SP, Brasil. Foram entrevistadas 388 famílias, com um total de 1.036 crianças de 0 a 12 anos. Das famílias, 289 não referiram qualquer acidente nas crianças nos dois anos anteriores. Em 99 famílias foi referido pelo menos 1 acidente, sendo registrado um total de 122. Os tipos de acidentes mais freqüentes foram as quedas (54,1%, ferimentos causados por objetos cortantes ou penetrantes (13,1% e mordeduras por animais (9,8%. As lesões mais freqüentes foram os cortes (26,2%, contusões (24,6% e escoriações (17,2%. A maior incidência de acidentes ocorreu em meninos de 5 a 9 anos seguido de meninos de 10 a 12 anos. A recuperação foi total em 88,5% dos casos, havendo 9,8% de casos com recuperação parcial, com sinais, 1 caso de recuperação parcial, com limitações, e um óbito. Em 91% dos casos não houve necessidade de internação, mas em 32,0% dos casos foram necessários 15 dias ou mais para que a recuperação se desse. O coeficiente de mortalidade encontrado foi de 114,9 óbitos para cem mil crianças menores de 12 anos por ano e a letalidade foi de 8,2 óbitos por mil acidentes. O estudo permitiu acrescentar série de dados complementares que facilitam a caracterização epidemiológica dos acidentes na infância.The epidemiological characteristics of those accidents which had happened to children in the previous 2 years were studied by means of interviews with the families of children less than 12 years of age, who had been assisted in two Health Centres in an outlying area of S. Paulo City, Brazil. A total of 388 families were interviewed, with a total of 1036 children less than 12 years old. Of these

  5. Fluid biomarkers in multiple system atrophy

    DEFF Research Database (Denmark)

    Laurens, Brice; Constantinescu, Radu; Freeman, Roy

    2015-01-01

    Despite growing research efforts, no reliable biomarker currently exists for the diagnosis and prognosis of multiple system atrophy (MSA). Such biomarkers are urgently needed to improve diagnostic accuracy, prognostic guidance and also to serve as efficacy measures or surrogates of target...... engagement for future clinical trials. We here review candidate fluid biomarkers for MSA and provide considerations for further developments and harmonization of standard operating procedures. A PubMed search was performed until April 24, 2015 to review the literature with regard to candidate blood...... and cerebrospinal fluid (CSF) biomarkers for MSA. Abstracts of 1760 studies were retrieved and screened for eligibility. The final list included 60 studies assessing fluid biomarkers in patients with MSA. Most studies have focused on alpha-synuclein, markers of axonal degeneration or catecholamines. Their results...

  6. RECENT ADVANCES IN BIOMARKERS IN SEVERE BURNS.

    Science.gov (United States)

    Ruiz-Castilla, Mireia; Roca, Oriol; Masclans, Joan R; Barret, Joan P

    2016-02-01

    The pathophysiology of burn injuries is tremendously complex. A thorough understanding is essential for correct treatment of the burned area and also to limit the appearance of organ dysfunction, which, in fact, is a key determinant of morbidity and mortality. In this context, research into biomarkers may play a major role. Biomarkers have traditionally been considered an important area of medical research: the measurement of certain biomarkers has led to a better understanding of pathophysiology, while others have been used either to assess the effectiveness of specific treatments or for prognostic purposes. Research into biomarkers may help to improve the prognosis of patients with severe burn injury. The aim of the present clinical review is to discuss new evidence of the value of biomarkers in this setting.

  7. Diagnostic and prognostic epigenetic biomarkers in cancer.

    Science.gov (United States)

    Costa-Pinheiro, Pedro; Montezuma, Diana; Henrique, Rui; Jerónimo, Carmen

    2015-01-01

    Growing cancer incidence and mortality worldwide demands development of accurate biomarkers to perfect detection, diagnosis, prognostication and monitoring. Urologic (prostate, bladder, kidney), lung, breast and colorectal cancers are the most common and despite major advances in their characterization, this has seldom translated into biomarkers amenable for clinical practice. Epigenetic alterations are innovative cancer biomarkers owing to stability, frequency, reversibility and accessibility in body fluids, entailing great potential of assay development to assist in patient management. Several studies identified putative epigenetic cancer biomarkers, some of which have been commercialized. However, large multicenter validation studies are required to foster translation to the clinics. Herein we review the most promising epigenetic detection, diagnostic, prognostic and predictive biomarkers for the most common cancers.

  8. The Indian Consensus Document on cardiac biomarker

    Directory of Open Access Journals (Sweden)

    I. Satyamurthy

    2014-01-01

    Full Text Available Despite recent advances, the diagnosis and management of heart failure evades the clinicians. The etiology of congestive heart failure (CHF in the Indian scenario comprises of coronary artery disease, diabetes mellitus and hypertension. With better insights into the pathophysiology of CHF, biomarkers have evolved rapidly and received diagnostic and prognostic value. In CHF biomarkers prove as measures of the extent of pathophysiological derangement; examples include biomarkers of myocyte necrosis, myocardial remodeling, neurohormonal activation, etc. In CHF biomarkers act as indicators for the presence, degree of severity and prognosis of the disease, they may be employed in combination with the present conventional clinical assessments. These make the biomarkers feasible options against the present expensive measurements and may provide clinical benefits.

  9. La transición epidemiológica de las y los adolescentes en México The epidemiologic transition among adolescents in Mexico

    Directory of Open Access Journals (Sweden)

    José Ignacio Santos-Preciado

    2003-01-01

    Full Text Available OBJETIVO: Identificar los niveles de salud de la adolescencia en México en su demografía, contexto social y económico. MATERIAL Y MÉTODOS: Se efectuó una revisión de la literatura y de estadísticas vitales, así como de encuestas de opinión, con la finalidad de evaluar el impacto de la transición epidemiológica frente a la disponibilidad y prioridades de los servicios de salud para adolescentes. El modelo epidemiológico de Omran se utilizó para clasificar las características demográficas, sociales y económicas de adolescentes mexicanos como un esfuerzo para definir su impacto en la transición epidemiológica de este grupo de edad. RESULTADOS: Los datos demográficos se presentan en una perspectiva de la transición epidemiológica, la cual nos permite realizar inferencias de las condiciones sociales, patrones de desarrollo y de necesidades en salud de este grupo poblacional en México. Los datos se presentan atendiendo a la demanda y disponibilidad de servicios de salud, el impacto de la educación, las oportunidades de empleo, el rol en la familia y el bienestar. Otros aspectos importantes presentados incluyen la educación sexual y la salud reproductiva, y los relacionados con el SIDA/VIH como pandemia en este grupo de edad. CONCLUSIONES: Los hallazgos presentados revelan que la secuencia tradicional de variables, en la explicación de la transición epidemiológica, no puede seguir manejándose como hasta ahora y nos sugieren de manera imperativa la necesidad de perfilar las necesidades de salud de la adolescencia desde un enfoque holístico, con énfasis en la promoción de estilos de vida sana, que favorezcan un desarrollo justo y equitativo y que además ayuden a enfocar la respuesta social organizada.ABSTRACT OBJECTIVE: To identify the health status of adolescents in Mexico in their demographic, social and economic context. MATERIAL AND METHODS: A literature search and review of vital statistics, and opinion surveys were

  10. Biomarkers: in medicine, drug discovery, and environmental health

    National Research Council Canada - National Science Library

    Vaidya, Vishal S; Bonventre, Joseph V

    2010-01-01

    ... Identification Using Mass Spectrometry Sample Preparation Protein Quantitation Examples of Biomarker Discovery and Evaluation Challenges in Proteomic Biomarker Discovery The Road Forward: Targeted ...

  11. PET Metabolic Biomarkers for Cancer

    Directory of Open Access Journals (Sweden)

    Etienne Croteau

    2016-01-01

    Full Text Available The body's main fuel sources are fats, carbohydrates (glucose, proteins, and ketone bodies. It is well known that an important hallmark of cancer cells is the overconsumption of glucose. Positron emission tomography (PET imaging using the glucose analog 18 F-fluorodeoxyglucose ( 18 F-FDG has been a powerful cancer diagnostic tool for many decades. Apart from surgery, chemotherapy and radiotherapy represent the two main domains for cancer therapy, targeting tumor proliferation, cell division, and DNA replication–-all processes that require a large amount of energy. Currently, in vivo clinical imaging of metabolism is performed almost exclusively using PET radiotracers that assess oxygen consumption and mechanisms of energy substrate consumption. This paper reviews the utility of PET imaging biomarkers for the detection of cancer proliferation, vascularization, metabolism, treatment response, and follow-up after radiation therapy, chemotherapy, and chemotherapy-related side effects.

  12. Caracterización clínico epidemiológica del síndrome depresivo

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    Andrés Vázquez Machado

    2001-06-01

    Full Text Available Se estudiaron 94 pacientes que acudieron a la consulta de psiquiatría de Cauto Cristo, Granma, Cuba, por un síndrome depresivo, con el objetivo de describir algunas de sus características clínico epidemiológicas. A todos los sujetos se les realizó una entrevista estructurada para conocer datos demográficos, características clínicas, eventos vitales, conducta suicida en el individuo y sus familiares y diagnóstico nosológico; éste último según los criterios del DSM IV. Predominaron las mujeres, el grupo de 35 a 54 años y los que tenían pareja. Los diagnósticos más frecuentes fueron trastorno distímico, trastorno adaptativo con estado de ánimo depresivo y trastorno depresivo mayor. La edad de inicio de los cuadros depresivos se sitúa en la tercera y cuarta década de la vida. El 28,5 % de los deprimidos ha tenido un intento suicida actual o anterior, y fue frecuente esa conducta en sus familiares. Las mujeres tuvieron más eventos vitales que los hombres, y los más frecuentes fueron los conflictos con la pareja y otros miembros de la familia, presentándose los síntomas de forma similar en ambos sexos. El humor depresivo, la falta de interés y disfrute en las actividades y la sensación de pérdida de energía o fatiga fueron los síntomas más frecuentemente referidos por los enfermos94 patients that visited the psychiatrist's office in Cauto Cristo, Granma, Cuba, due to a depressive syndrome were studied in order to describe some of their clinical and epidemiological characteristics. All the subjects participated in an interview structured to know demographic data, clinical characteristics, vital events, suicidal behavior in the individual and his relatives and nosological diagnosis; this latter according to the criteria of DSM IV. There was a predominance of women, of the group aged 35-54 and of those having a partner. The most frequent diagnoses were dysthymic disorder, adaptational disturbance with depressive mood and

  13. Epidemiological findings of ocular trauma in childhood Achados epidemiológicos do trauma ocular na infância

    Directory of Open Access Journals (Sweden)

    Angelino Julio Cariello

    2007-03-01

    Full Text Available PURPOSE: To describe epidemiological findings of ocular trauma in childhood in an emergency unit. METHODS: A retrospective study was carried out including patients under 16 years old who were treated for ocular trauma at the emergency unit of the Federal University of São Paulo from September 2001 to September 2004. Age, sex, involved eye, place, circumstance and mechanism of injury, initial visual acuity and immediate management were recorded. RESULTS: A total of 273 patients were included in the study. The age group comprising most cases was 7 to 10 years (39.9%. The most frequent cause of ocular injury was traumatism by external agents like stone, iron and wood objects (27.9%. The commonest place was the home (53.1%. Initial visual acuity was over 20/40 in 63.4% of cases. Closed globe injury occurred in 201 (73.6% accidents. Seventy-six children (27. 8% were treated with medicines and in forty-eight (17.6% cases surgery was necessary. CONCLUSION: Ocular trauma in childhood was more frequent in the male schoolchild and was due mostly to traumatism with agents like stone, wood and iron pieces, domestic utensils and leisure objects. The injuries occurred most frequently at home. Closed globe injuries predominated. Programs of education and prevention for ocular trauma in childhood are necessary.OBJETIVO: Descrever os achados epidemiológicos do trauma ocular na infância em uma unidade de emergência. MÉTODOS: Em estudo retrospectivo, foram analisados prontuários de pacientes menores que 16 anos que foram atendidos por trauma ocular no Pronto-Socorro de Oftalmologia da Universidade Federal de São Paulo de setembro de 2001 a setembro de 2004. Foram coletadas informações a respeito da idade, sexo, olho envolvido, local, circunstância e mecanismo do trauma, acuidade visual inicial e conduta imediata. RESULTADOS: Um total de 273 pacientes foi incluído no estudo. A faixa etária com maior número de casos foi a de 7 a 10 anos (39,9%. A causa

  14. CBD: a biomarker database for colorectal cancer.

    Science.gov (United States)

    Zhang, Xueli; Sun, Xiao-Feng; Cao, Yang; Ye, Benchen; Peng, Qiliang; Liu, Xingyun; Shen, Bairong; Zhang, Hong

    2018-01-01

    Colorectal cancer (CRC) biomarker database (CBD) was established based on 870 identified CRC biomarkers and their relevant information from 1115 original articles in PubMed published from 1986 to 2017. In this version of the CBD, CRC biomarker data were collected, sorted, displayed and analysed. The CBD with the credible contents as a powerful and time-saving tool provide more comprehensive and accurate information for further CRC biomarker research. The CBD was constructed under MySQL server. HTML, PHP and JavaScript languages have been used to implement the web interface. The Apache was selected as HTTP server. All of these web operations were implemented under the Windows system. The CBD could provide to users the multiple individual biomarker information and categorized into the biological category, source and application of biomarkers; the experiment methods, results, authors and publication resources; the research region, the average age of cohort, gender, race, the number of tumours, tumour location and stage. We only collect data from the articles with clear and credible results to prove the biomarkers are useful in the diagnosis, treatment or prognosis of CRC. The CBD can also provide a professional platform to researchers who are interested in CRC research to communicate, exchange their research ideas and further design high-quality research in CRC. They can submit their new findings to our database via the submission page and communicate with us in the CBD.Database URL: http://sysbio.suda.edu.cn/CBD/.

  15. Biomarkers in DILI: one more step forward

    Directory of Open Access Journals (Sweden)

    Mercedes Robles-Díaz

    2016-08-01

    Full Text Available Despite being relatively rare, drug-induced liver injury (DILI is a serious condition, both for the individual patient due to the risk of acute liver failure, and for the drug development industry and regulatory agencies due to associations with drug development attritions, black box warnings and postmarketing withdrawals. A major limitation in DILI diagnosis and prediction is the current lack of specific biomarkers. Despite refined usage of traditional liver biomarkers in DILI, reliable disease outcome predictions are still difficult to make. These limitations have driven the growing interest in developing new more sensitive and specific DILI biomarkers, which can improve early DILI prediction, diagnosis and course of action. Several promising DILI biomarker candidates have been discovered to date, including mechanistic-based biomarker candidates such as glutamate dehydrogenase, high-mobility group box 1 protein and keratin-18, which can also provide information on the injury mechanism of different causative agents. Furthermore, microRNAs have received much attention lately as potential non-invasive DILI biomarker candidates, in particular miR-122. Advances in omics technologies offer a new approach for biomarker exploration studies. The ability to screen a large number of molecules (for example metabolites, proteins or DNA simultaneously enables the identification of ‘toxicity signatures’, which may be used to enhance preclinical safety assessments and disease diagnostics. Omics-based studies can also provide information on the underlying mechanisms of distinct forms of DILI that may further facilitate the identification of early diagnostic biomarkers and safer implementation of personalized medicine. In this review we summarize recent advances in the area of DILI biomarker studies.

  16. Biomarkers for equine joint injury and osteoarthritis.

    Science.gov (United States)

    McIlwraith, C Wayne; Kawcak, Christopher E; Frisbie, David D; Little, Christopher B; Clegg, Peter D; Peffers, Mandy J; Karsdal, Morten A; Ekman, Stina; Laverty, Sheila; Slayden, Richard A; Sandell, Linda J; Lohmander, L S; Kraus, Virginia B

    2018-03-01

    We report the results of a symposium aimed at identifying validated biomarkers that can be used to complement clinical observations for diagnosis and prognosis of joint injury leading to equine osteoarthritis (OA). Biomarkers might also predict pre-fracture change that could lead to catastrophic bone failure in equine athletes. The workshop was attended by leading scientists in the fields of equine and human musculoskeletal biomarkers to enable cross-disciplinary exchange and improve knowledge in both. Detailed proceedings with strategic planning was written, added to, edited and referenced to develop this manuscript. The most recent information from work in equine and human osteoarthritic biomarkers was accumulated, including the use of personalized healthcare to stratify OA phenotypes, transcriptome analysis of anterior cruciate ligament (ACL) and meniscal injuries in the human knee. The spectrum of "wet" biomarker assays that are antibody based that have achieved usefulness in both humans and horses, imaging biomarkers and the role they can play in equine and human OA was discussed. Prediction of musculoskeletal injury in the horse remains a challenge, and the potential usefulness of spectroscopy, metabolomics, proteomics, and development of biobanks to classify biomarkers in different stages of equine and human OA were reviewed. The participants concluded that new information and studies in equine musculoskeletal biomarkers have potential translational value for humans and vice versa. OA is equally important in humans and horses, and the welfare issues associated with catastrophic musculoskeletal injury in horses add further emphasis to the need for good validated biomarkers in the horse. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 36:823-831, 2018. © 2017 Orthopaedic Research Society. Published by Wiley Periodicals, Inc.

  17. Cardiac Biomarkers and Cycling Race

    Directory of Open Access Journals (Sweden)

    Caroline Le Goff, Jean-François Kaux, Sébastien Goffaux, Etienne Cavalier

    2015-06-01

    Full Text Available In cycling as in other types of strenuous exercise, there exists a risk of sudden death. It is important both to understand its causes and to see if the behavior of certain biomarkers might highlight athletes at risk. Many reports describe changes in biomarkers after strenuous exercise (Nie et al., 2011, but interpreting these changes, and notably distinguishing normal physiological responses from pathological changes, is not easy. Here we have focused on the kinetics of different cardiac biomarkers: creatin kinase (CK, creating kinase midbrain (CK-MB, myoglobin (MYO, highly sensitive troponin T (hs-TnT and N-terminal brain natriuretic peptide (NT-proBNP. The population studied was a group of young trained cyclists participating in a 177-km cycling race. The group of individuals was selected for maximal homogeneity. Their annual training volume was between 10,000 and 16,000 kilometers. The rhythm of races is comparable and averages 35 km/h, depending on the race’s difficulty. The cardiac frequency was recorded via a heart rate monitor. Three blood tests were taken. The first blood test, T0, was taken approximately 2 hours before the start of the race and was intended to gather values which would act as references for the following tests. The second blood test, T1, was realized within 5 minutes of their arrival. The third and final blood test, T3, was taken 3 hours following their arrival. The CK, CK-MB, MYO, hs-TnT and NT-proBNP were measured on the Roche Diagnostic modular E (Manhein, Germany. For the statistical analysis, an ANOVA and post hoc test of Scheffé were calculated with the Statistica Software version 9.1. We noticed an important significant variation in the cardiac frequency between T0 and T1 (p < 0.0001, T0 and T3 (p < 0.0001, and T1 and T3 (p < 0.01. Table 1 shows the results obtained for the different biomarkers. CK and CK-MB showed significant variation between T0-T1 and T0-T3 (p < 0.0001. Myoglobin increased significantly

  18. Mining biomarker information in biomedical literature

    Directory of Open Access Journals (Sweden)

    Younesi Erfan

    2012-12-01

    Full Text Available Abstract Background For selection and evaluation of potential biomarkers, inclusion of already published information is of utmost importance. In spite of significant advancements in text- and data-mining techniques, the vast knowledge space of biomarkers in biomedical text has remained unexplored. Existing named entity recognition approaches are not sufficiently selective for the retrieval of biomarker information from the literature. The purpose of this study was to identify textual features that enhance the effectiveness of biomarker information retrieval for different indication areas and diverse end user perspectives. Methods A biomarker terminology was created and further organized into six concept classes. Performance of this terminology was optimized towards balanced selectivity and specificity. The information retrieval performance using the biomarker terminology was evaluated based on various combinations of the terminology's six classes. Further validation of these results was performed on two independent corpora representing two different neurodegenerative diseases. Results The current state of the biomarker terminology contains 119 entity classes supported by 1890 different synonyms. The result of information retrieval shows improved retrieval rate of informative abstracts, which is achieved by including clinical management terms and evidence of gene/protein alterations (e.g. gene/protein expression status or certain polymorphisms in combination with disease and gene name recognition. When additional filtering through other classes (e.g. diagnostic or prognostic methods is applied, the typical high number of unspecific search results is significantly reduced. The evaluation results suggest that this approach enables the automated identification of biomarker information in the literature. A demo version of the search engine SCAIView, including the biomarker retrieval, is made available to the public through http

  19. Desenvolvimento da Vigilância Epidemiológica de Fronteira no contexto da Globalização: conceitos e marcos teóricos.

    Directory of Open Access Journals (Sweden)

    Robson BRUNIERA-OLIVEIRA

    2014-12-01

    Full Text Available Objetivo. Apresentar e analisar as ações desenvolvidas para a implementação e desenvolvimento de Vigilância Epidemiológica de Fronteiras, nos Blocos Econômicos Multinacionais, particularmente na América do Sul e Brasil. Metodologia. Foi realizado um estudo de revisão narrativa incluindo artigos científicos, documentos técnicos, diretrizes, normas, manuais, pautas de reuniões ou qualquer outro documento que fosse relacionado ao desenvolvimento e implementação de ações e programas de Vigilância Epidemiológica em Fronteiras. O estudo foi baseado nos sites das instituições/organizações multinacionais e nas bases MedLine, PubMed, Scielo e Scopus. Resultados. Foram identificados a criação de órgãos e ações no intuito de implementar e desenvolver a vigilância epidemiológica de fronteiras para os seguintes blocos: União Europeia (Health Security Committee, European Center for Disease Prevention and Control, Sistema de alerta rápido e resposta, General Rapid Alert System e Rede de Monitoramento Ad Hoc; Tratado Norte-Americano de Livre Comércio (Border Infectious Disease Surveillance, “Projeto de Vigilância e Alerta Rápido de Doenças Infeciosas” ; Mercado Comum do Sul ( Reunião de Ministros da Saúde do Mercosul, Subgrupo de Trabalho 11 Saúde e Subcomissão Controle Sanitário de Portos, Aeroportos, Terminais e Passos Fronteiriços Terrestres; e União de Nações Sul-Americanas. Conclusões. Os programas e politicas desenvolvidos até o momento refletem o reconhecimento da importância do assunto por parte dos Estados Membros da OMS. Uma maior integração, com troca de informações, incluindo fluxos, frameworks, planos de preparação e o fortalecimento de áreas estratégicas como de energia e transporte deve ser incentivada intra e inter blocos.

  20. Vigilancia epidemiológica de la tuberculosis pulmonar atendida en el nivel especializado a partir de dos fuentes de información: Valladolid

    Directory of Open Access Journals (Sweden)

    Tejero Encinas Silvia

    2003-01-01

    Full Text Available Fundamento: La tuberculosis pulmonar en España tiene una frecuencia superior a la que le correspondería, dado su desarrollo social y sanitario. Aparte de algunos estudios puntuales, la incidencia se conoce a partir del Sistema de Notificación como Enfermedad de Declaración Obligatoria (EDO, en el que se ha detectado algún grado de infradeclaración. Se ha planteado si se puede mejorar esta información empleando además otro registro, concretamente el Conjunto Mínimo Básico de Datos (CMBD. Métodos: Se trata de un estudio retrospectivo del periodo 1996-2000, llevado a cabo en la población de un área de salud de 220.572 habitantes. Se han utilizado los datos del registro EDO en el nivel de asistencia especializada y los del registro CMBD con el diagnóstico de tuberculosis pulmonar. Se calcularon las tasas de incidencia para cada fuente y según el método captura-recaptura. Se analizaron características epidemiológicas de las personas como: edad, género, lugar de residencia, condición de bacilífero, y datos asistenciales de los casos ingresados como, estancia media, tipo de ingreso, tipo de alta, servicio clínico. Resultados: La incidencia media anual registrada en el nivel de atención especializada fue de 16,6 por 10(5 habitantes en el registro EDO, 20,4 casos por 10(5 habitantes en el CMBD y de 23,1 por 10(5 habitantes combinando ambas fuentes. La incidencia estimada con el método captura-recaptura fue de 24,4 por 10(5 hab. (IC95%: 23,5-25,3. Conclusiones: Cualquier sistema de información que aporte datos fiables sirve para mejorar la vigilancia epidemiológica aunque haya sido diseñado con otro fin. Se trata de conocer sus limitaciones y peculiaridades. El CMBD proporciona información de interés epidemiológico no contenida en los partes de EDO. La aplicación del método captura-recaptura es una alternativa para estimar tasas más reales de tuberculosis pulmonar.

  1. Cólera en Apartadó, Antioquia: aspectos clínicos y epidemiológicos Cholera in Apartadó, Colombia: clinical and epidemiological aspects

    Directory of Open Access Journals (Sweden)

    Gustavo A. Uribe Miller

    1994-04-01

    Full Text Available Este trabajo fue realizado en el Hospital Regional de Apartadó, Antioquia, motivado por la falta de experiencia con cólera en la región y por la similitud clínica y epidemiológica que esta enfermedad presenta con otras enteritis agudas, endémicas en la zona. Los objetivos fueron: analizar algunas variables epidemiológicas y clínicas, verificar la eficacia del tratamiento y comparar el comportamiento del cólera con el de la Enfermedad Diarreica Aguda (EDA sin cólera. Se revisaron las historias clínicas y epidemiológicas de 181 pacientes atendidos entre agosto 11 y octubre 11 de 1991. Se configuró un estudio retrospectivo con las siguientes variables: coprocultivo para Vibrio cholerae, edad, sexo, ocupación, procedencia, estado de hidratación al consultar, duración de la estadía hospitalaria, equilibrio hídrico, asociación epidemio16gica y condiciones sanitarias. Se confirmó cólera por coprocultivo en 87 casos (48%. Al comparar el cólera con la EDA sin cólera, sólo se encontró diferencia significativa en cuanto al grupo de edad afectado (p=O.042 ya la duración de la hospitalización (p=O.O16. El tratamiento recomendado por la OMS fue eficaz según el criterio clínico. No hubo complicaciones ni reingresos; ningún paciente falleció.

    One hundred and eighty one patients with acute diarrhea disease (ADD were analyzed from the clinical and epidemiological points of view; 87 of them (48.1% had confirmed cholera while the remaining 94 (51.9% were classified as non-cholera ADD; the only significant differences between these two groups were observed in age and days of hospital stay: cholera predominated In patients older than 5 years (p=O.O42 and the frequency of a hospital stay longer than 2 days was higher in cholera patients (p=O.O16. WHO recommended treatment was effective according to clinical criteria; neither complications nor deaths were found.

  2. Dietary and health biomarkers-time for an update

    NARCIS (Netherlands)

    Dragsted, L.O.; Gao Qizian,; Praticò, G.; Manach, Claudine; Wishart, D.S.; Scalbert, A.; Feskens, E.J.M.

    2017-01-01

    In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health.

  3. Quantitative imaging as cancer biomarker

    Science.gov (United States)

    Mankoff, David A.

    2015-03-01

    The ability to assay tumor biologic features and the impact of drugs on tumor biology is fundamental to drug development. Advances in our ability to measure genomics, gene expression, protein expression, and cellular biology have led to a host of new targets for anticancer drug therapy. In translating new drugs into clinical trials and clinical practice, these same assays serve to identify patients most likely to benefit from specific anticancer treatments. As cancer therapy becomes more individualized and targeted, there is an increasing need to characterize tumors and identify therapeutic targets to select therapy most likely to be successful in treating the individual patient's cancer. Thus far assays to identify cancer therapeutic targets or anticancer drug pharmacodynamics have been based upon in vitro assay of tissue or blood samples. Advances in molecular imaging, particularly PET, have led to the ability to perform quantitative non-invasive molecular assays. Imaging has traditionally relied on structural and anatomic features to detect cancer and determine its extent. More recently, imaging has expanded to include the ability to image regional biochemistry and molecular biology, often termed molecular imaging. Molecular imaging can be considered an in vivo assay technique, capable of measuring regional tumor biology without perturbing it. This makes molecular imaging a unique tool for cancer drug development, complementary to traditional assay methods, and a potentially powerful method for guiding targeted therapy in clinical trials and clinical practice. The ability to quantify, in absolute measures, regional in vivo biologic parameters strongly supports the use of molecular imaging as a tool to guide therapy. This review summarizes current and future applications of quantitative molecular imaging as a biomarker for cancer therapy, including the use of imaging to (1) identify patients whose tumors express a specific therapeutic target; (2) determine

  4. Biomarker monitoring in sports doping control.

    Science.gov (United States)

    Pottgiesser, Torben; Schumacher, Yorck Olaf

    2012-06-01

    Biomarker monitoring can be considered a new era in the effort against doping. Opposed to the old concept in doping control of direct detection of a prohibited substance in a biological sample such as urine or blood, the new paradigm allows a personalized longitudinal monitoring of biomarkers that indicate non-physiological responses independently of the used doping technique or substance, and may cause sanctioning of illicit practices. This review presents the development of biomarker monitoring in sports doping control and focuses on the implementation of the Athlete Biological Passport as the current concept of the World Anti Doping Agency for the detection of blood doping (hematological module). The scope of the article extends to the description of novel biomarkers and future concepts of application.

  5. Cellular Models for Environmental Toxicant Biomarker Discovery

    National Research Council Canada - National Science Library

    Halverson, Kelly M; Lewsis, John A; Jackson, David A; Dennis, William; Brennan, Linda; Krakaner, Teresa

    2006-01-01

    ...) is the development of biomarkers of exposure, effect, and susceptibility. As exposure monitoring using environmental sampling equipment can be impractical and doesn't account for differences in individual responses, new methodologies must be sought...

  6. Radiation Biomarker Research Using Mass Spectrometry

    National Research Council Canada - National Science Library

    Bach, Stephan B; Hubert, Walter

    2007-01-01

    .... This review is intended to give an overview of mass spectrometry and its application to biological systems and biomarker discovery and how that might relate to relevant radiation dosimetry studies...

  7. The development and applications of biomarkers

    International Nuclear Information System (INIS)

    Normandy, J.; Peeters, J.

    1994-01-01

    This report is a compilation of submitted abstracts of scientific papers presented at the second Department of Energy-supported workshop on the use and applications of biomarkers held in Santa Fe, New Mexico, from April 26--29, 1994. The abstracts present a synopsis of the latest scientific developments in biomarker research and how these developments meet with the practical needs of the occupational physician as well as the industrial hygienist and the health physicist. In addition to considering the practical applications and potential benefits of this promising technology, the potential ethical and legal ramifications of using biomarkers to monitor workers are discussed. The abstracts further present insights on the present benefits that can be derived from using biomarkers as well as a perspective on what further research is required to fully meet the needs of the medical community

  8. International Team Identifies Biomarker for Scleroderma

    Science.gov (United States)

    ... Spotlight on Research International Team Identifies Biomarker for Scleroderma By Kirstie Saltsman, Ph.D. | May 5, 2014 ... molecule correlates with a more severe form of scleroderma, a chronic autoimmune disorder that involves the abnormal ...

  9. Biomarkers in psoriasis and psoriatic arthritis.

    Science.gov (United States)

    Villanova, Federica; Di Meglio, Paola; Nestle, Frank O

    2013-04-01

    Psoriasis is a common immune-mediated disease of the skin, which associates in 20-30% of patients with psoriatic arthritis (PsA). The immunopathogenesis of both conditions is not fully understood as it is the result of a complex interaction between genetic, environmental and immunological factors. At present there is no cure for psoriasis and there are no specific markers that can accurately predict disease progression and therapeutic response. Therefore, biomarkers for disease prognosis and response to treatment are urgently needed to help clinicians with objective indications to improve patient management and outcomes. Although many efforts have been made to identify psoriasis/PsA biomarkers none of them has yet been translated into routine clinical practice. In this review we summarise the different classes of possible biomarkers explored in psoriasis and PsA so far and discuss novel strategies for biomarker discovery.

  10. Novel Biomarker for Prognosis, Treatment Response

    Science.gov (United States)

    An NCI Cancer Currents blog about a study of a new type of cancer biomarker that measures the extent of chromosomal instability as a way to potentially predict patient prognosis and help guide cancer treatment choices.

  11. The development and applications of biomarkers

    Energy Technology Data Exchange (ETDEWEB)

    Normandy, J.; Peeters, J. [eds.

    1994-04-15

    This report is a compilation of submitted abstracts of scientific papers presented at the second Department of Energy-supported workshop on the use and applications of biomarkers held in Santa Fe, New Mexico, from April 26--29, 1994. The abstracts present a synopsis of the latest scientific developments in biomarker research and how these developments meet with the practical needs of the occupational physician as well as the industrial hygienist and the health physicist. In addition to considering the practical applications and potential benefits of this promising technology, the potential ethical and legal ramifications of using biomarkers to monitor workers are discussed. The abstracts further present insights on the present benefits that can be derived from using biomarkers as well as a perspective on what further research is required to fully meet the needs of the medical community.

  12. Have biomarkers made their mark? A brief review of dental biomarkers

    Directory of Open Access Journals (Sweden)

    Mohammed Kaleem Sultan

    2014-01-01

    Full Text Available Biomarkers are substances that are released into the human body by tumor cells or by other cells in response to tumor. A high level of a tumor marker is considered a sign of certain cancer, which makes biomarker the subject of many testing methods for the diagnosis of cancers. In recent times, these biomarkers have been successfully isolated to diagnose dental-related tumors, benign and malignant conditions. This article is a brief review of literature for various biomarkers used in the field of dentistry.

  13. Estudio clínico-epidemiológico de enterobiasis en preescolares y escolares de Taratara, Estado Falcón, Venezuela

    OpenAIRE

    CAZORLA, DALMIRO J; ACOSTA, MARÍA E; ZÁRRAGA, ANAVELÍN; MORALES, PEDRO

    2006-01-01

    Durante Julio y Noviembre 2004, se realizó un estudio para determinar los perfiles clínicos y epidemiológicos de enterobiasis en 100 preescolares (2-5 años) y escolares (6-12 años) de Taratara, Estado Falcón, Venezuela. Se hizo evaluación clínica y anamnesis para la búsqueda de signos y síntomas y conductas antihigiénicas de los niños que usualmente se encuentran asociados a enterobiasis. La detección de la infección por E. vermicularis se realizó mediante la aplicación de la técnica de la ci...

  14. Vigilância epidemiológica da transmissão vertical da sífilis: dados de seis unidades federativas no Brasil

    OpenAIRE

    Valeria Saraceni; Gerson Fernando Mendes Pereira; Mariangela Freitas da Silveira; Maria Alix Leite Araujo; Angelica Espinosa Miranda

    2017-01-01

    RESUMO Objetivo Descrever o perfil epidemiológico dos casos notificados de sífilis em gestantes e sífilis congênita nos estados brasileiros do Amazonas, Ceará, Espírito Santo, Rio de Janeiro e Rio Grande do Sul e no Distrito Federal a partir de dados do Sistema Nacional de Agravos de Notificação (SINAN). Métodos Estudo descritivo incluindo avaliação ecológica e transversal. Foram utilizados dados do SINAN Net. Foram calculadas a taxa de detecção de sífilis em gestantes e a taxa de incidênci...

  15. Impacto da necropsia na definição da infecção fúngica e avaliação epidemiológica

    OpenAIRE

    Elisabeth Pereira Lopes, Nadja

    2010-01-01

    O resultado de óbitos mal-definidos torna indispensável à necropsia para que seja elucidada a causa morte. Dessa forma, este estudo visou verificar infecções fúngicas isoladas ou em associação com outras doenças relacionadas ao óbito, bem como dados epidemiológicos que possam ter contribuído. Durante a necropsia, foram realizados exames micológicos e histopatológicos. Os órgãos acometidos por fungos foram pulmões, cérebro, rim, meninges, fígado e coração, sendo diagnosticadas p...

  16. Indicadores epidemiológicos aplicáveis a estudos sobre a associação entre saneamento e saúde de base municipal

    OpenAIRE

    Costa,Silvano Silvério da; Heller,Léo; Brandão,Cristina Celia Silveira; Colosimo,Enrico Antônio

    2005-01-01

    É relativamente recente no país a prática da vigilância ambiental em saúde, sendo que a vigilância da qualidade da água para consumo humano, parte integrante da vigilância ambiental em saúde, ressente-se de estudos e pesquisas que forneçam suporte científico à formulação de instrumentos para a prática de tal vigilância. Nesse campo, a formulação e seleção de indicadores epidemiológicos constituem atividade essencial para representar os efeitos da insuficiência das ações de saneamento sobre a ...

  17. Boletim Epidemiológico Observações: Vol. 5 (2016), Número Especial 8, Alimentação e Nutrição

    OpenAIRE

    Instituto Nacional de Saúde Doutor Ricardo Jorge

    2016-01-01

    Ficha técnica: Diretor: Fernando de Almeida; Editores:Carlos Matias Dias, Elvira Silvestre; Conselho Editorial Científico: Carlos Matias Dias, Manuela Cano, Jorge Machado, Manuela Caniça, Peter Jordan, Sílvia Viegas, Luciana Costa. Número Especial dedicado à Alimentação e Nutrição do Boletim Epidemiológico Observações. Observações é uma publicação científica do INSA, IP, que visa contribuir para o conhecimento da saúde da população, os fatores que a influenciam, a decisão e a intervenção e...

  18. Boletim Epidemiológico Observações: Vol. 6 (2017), Número Especial 9, Doenças Não Transmissíveis

    OpenAIRE

    Instituto Nacional de Saúde Doutor Ricardo Jorge, IP

    2017-01-01

    Retificações nas referências em 17/8/2017 Número Especial dedicado às Doenças Não Transmissíveis do Boletim Epidemiológico Observações. Observações é uma publicação científica do INSA, IP, que visa contribuir para o conhecimento da saúde da população, os fatores que a influenciam, a decisão e a intervenção em Saúde Pública, assim como a avaliação do seu impacte na população portuguesa. Através do acesso público e gratuito a resultados científicos gerados por atividades de observação em...

  19. Perfil epidemiológico do trauma ocular penetrante antes e após o novo código de trânsito

    OpenAIRE

    Silber,Paulo Caldas; Souza,Luciene Barbosa de; Tongu,Maira Tiyomi Sacata

    2002-01-01

    Objetivo: Comparar o perfil epidemiológico dos pacientes com trauma ocular penetrante (TOP) antes e após a regulamentação do novo código de trânsito. Métodos: Estudo retrospectivo de 253 pacientes com TOP examinados na Seção de Trauma Ocular (UNIFESP) de janeiro de 1997 a abril de 1999. Os pacientes foram divididos em dois grupos: Grupo I, pacientes com trauma ocular antes da implantação do novo código; Grupo II, história de trauma após sua implantação. Os pacientes foram avaliados em relação...

  20. Salivary pH: A diagnostic biomarker

    OpenAIRE

    Baliga, Sharmila; Muglikar, Sangeeta; Kale, Rahul

    2013-01-01

    Objectives: Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. Study D...

  1. Descentralização das ações de vigilância epidemiológica em Pernambuco, Brasil

    Directory of Open Access Journals (Sweden)

    Ana Coelho de Albuquerque

    2015-04-01

    Full Text Available O objetivo do estudo foi analisar a relação entre o processo de descentralização da gestão do Sistema Único de Saúde (SUS e o desenvolvimento das ações de vigilância epidemiológica em municípios de Pernambuco, Brasil. A estratégia de trabalho consistiu num estudo descritivo e exploratório qualitativo/quantitativo, com a realização de uma pesquisa de caráter documental e entrevistas semiestruturadas com informantes-chave, como também um estudo ecológico espacial e de série temporal, no qual foi traçada uma série histórica de dez anos (2001-2010, utilizando-se indicadores selecionados. O estudo evidenciou que o processo de descentralização em Pernambuco obteve adesão e evoluiu, porém com a existência de desigualdades e fragilidades no seu desenvolvimento, também apontadas pela oscilação nos resultados da série histórica dos indicadores selecionados. Assim, mesmo que o processo de descentralização das ações de vigilância epidemiológica ainda seja incipiente em alguns municípios, sabe-se que o papel de executor das ações promove o empoderamento do nível municipal, quando o mesmo passa a produzir as informações necessárias à tomada de decisão

  2. Perfil epidemiológico dos pacientes com ptose congênita no hospital regional de São José

    Directory of Open Access Journals (Sweden)

    Astor Grumann Júnior

    2011-12-01

    Full Text Available OBJETIVO: Traçar um perfil epidemiológico dos pacientes com ptose congênita no Hospital Regional de São José (HRSJ, descrevendo as características gerais das ptoses congênitas, incluindo a coexistência de estrabismo e a prevalência de ambliopia. MÉTODOS: Foi realizado um estudo epidemiológico com delineamento transversal, baseado na análise dos prontuários de pacientes com ptose congênita atendidos no Departamento de Plástica Ocular e Órbita do HRSJ, no período de julho de 1998 a julho de 2008. RESULTADOS: Foram analisados 42 pacientes (56 olhos. A idade média foi de 7,2 anos e o gênero mais prevalente foi o masculino (66,7%. Foi encontrado unilateralidade da ptose em 66,7% dos casos, associação com estrabismo em 19% e fenômeno de Marcus Gunn em 9,5%. Ambliopia foi encontrada em 17% dos olhos afetados. Na classificação, 38,5% dos olhos tinham ptose severa e 63% tinham excursão do elevador fraca ou ausente. A conduta foi cirúrgica para 57,2% dos casos e a técnica mais prevalente foi elevação ao Frontal (75%. CONCLUSÃO: No presente estudo, a prevalência de ambliopia nos pacientes com ptose congênita foi maior que da população geral, reforçando a importância de uma avaliação oftalmológica precoce destes pacientes.

  3. Estudio epidemiológico de los niveles de actividad física en los estudiantes de Educación Secundaria Obligatoria

    Directory of Open Access Journals (Sweden)

    José Ramón Serra Puyal

    2006-03-01

    Full Text Available Las descripciones epidemiológicas nos indican la situación en la que se encuentra una población respecto a los aspectos de salud, y en este caso concreto su relación con la actividad física. El conocimiento de estas investigaciones podrá ser utilizado para fomentar la prevención y el control de algunas enfermedades, así como para la promoción de la salud. En esta investigación pretendemos realizar una descripción epidemiológica de la Actividad Física entre una muestra del alumnado de Educación Secundaria Obligatoria del I.E.S. San Alberto Magno de Sabiñánigo, en Huesca. Utilizamos el cuestionario “Four by one-day Physical Activity Questionaire” recogiendo la estimación de actividad física total, dentro y fuera ámbito escolar, mediante cuatro registros Concluimos que se detectaron altos niveles de inactividad, más acusados en la población femenina y que aumenta con la edad. Es muy interesante expresar el gasto energético dividiéndolo en actividades laborales, deportivas y cotidianas. Por otra parte no se reflejaron relaciones significativas entre el gasto energético y otras variables como tabaco, televisión o estudio, pero aportan información sobre los hábitos de los adolescentes. Por los datos obtenidos se deduce que es factible el uso de la percepción del alumno sobre su nivel de realización de actividad física.

  4. Caracterización clínico epidemiológica de pacientes afectados por pie diabético

    Directory of Open Access Journals (Sweden)

    Dania Núñez Álvarez

    2018-01-01

    Full Text Available Introducción: el pie diabético constituye un problema de salud en los pacientes portadores de diabetes mellitus y se registra como la primera causa de amputación no traumática de los miembros. El conocimiento de sus particularidades clínico-epidemiológicas resulta de sumo interés. Objetivo: caracterizar clínica y epidemiológicamente a los pacientes con pie diabético neuroinfeccioso en el Hospital "Dr. Joaquín Castillo Duany" de Santiago de Cuba. Método: se realizó un estudio descriptivo retrospectivo. El universo estuvo constituido por 96 pacientes diagnosticados con pie diabético durante el periodo comprendido entre el 2011 y el 2015. Se emplearon variables demográficas y relacionadas con factores de riesgo generales y específicos del pie diabético. Resultados: el pie diabético predominó entre la cuarta y sexta décadas de vida (24,7 % y en pacientes del sexo femenino (59,7 %. La diabetes mellitus tipo 2 estuvo representada en el 52,5 %. Mientras el factor de riesgo general de pie diabético más frecuente fue la obesidad (56,7 %, la neuropatía diabética, como factor de riesgo específico se presentó en el 98,9 % de los enfermos estudiados. Conclusiones: el pie diabético predominó en la cuarta y sexta décadas de la vida y en el sexo femenino. El mayor porcentaje de los pacientes era portador de diabetes mellitus tipo 2. La obesidad, la neuropatía diabética periférica, el sobrepeso, y la hiperglucemia constituyeron los factores de riesgo prevalecientes.

  5. Perfil clínico-epidemiológico da hanseníase em menores de 15 anos no município de Juazeiro-BA

    Directory of Open Access Journals (Sweden)

    Igara Cavalcanti Feitosa Luna

    2013-06-01

    Full Text Available Objetivo: Descrever o perfil epidemiológico e clínico dos casos novos de hanseníase em menores de 15 anos notificados à Secretaria Municipal de Saúde (SMS de Juazeiro-BA, no período de 2001 a 2010. Métodos: Trata-se de um estudo quantitativo, de natureza exploratória e descritiva, realizado a partir da análise dos dados contidos no Sistema de Informação de Agravos de Notificação (SINAN municipal. Resultados: Os resultados mostraram que145 (7,94% casos novos de hanseníase ocorreram em menores de 15 anos. Verificaram-se taxas de detecção altas para essa faixa etária, com predominância no sexo feminino (n=81; 55,86% e maior acometimento na faixa etária entre 10 e 14 anos (n=85; 58,62%. As formas paucibacilares (n=107; 74,48% da doença predominaram sobre as formas multibacilares (n=37; 25,52%, sendo a forma clínica tuberculoide (n=80; 55,17% a mais prevalente. As incapacidades atingiram 18 (12,41% dos pacientes avaliados no diagnóstico e 15 (10,34% na alta. Uma grande parte de casos (n=58; 40,07% deixou de ser avaliada ou foi ignorada. Conclusão: O perfil epidemiológico e clínico da ocorrência de casos novos de hanseníase no município de Juazeiro-BA evidenciou que os coeficientes de detecção geral de hanseníase e em menores de 15 anos se mantiveram em nível hiperendêmico no período avaliado.

  6. Quality assurance in biomarker measurement.

    Science.gov (United States)

    Aitio, A; Apostoli, P

    1995-05-01

    Quality assurance (QA) concerns the validity of all the analytical processes (from collection of the samples to interpretation of the results). It is not an abstract concept but must be adapted to the different situations such as the different exposure levels, the different analytical methods, and the context of use (risk assessment procedures, research, routine determinations). The main requirements in QA programmes regard the control of all the known sources of preanalytical and analytical variations, while the instruments with which adequate QA can be implemented are the certified materials and the quality control programmes (quality manual, internal and external quality controls). Another important concept in QA is that measurements must be placed a different metrological levels: at the highest there are the methods (definitive, reference) to be used for assessing accuracy of routine methods. QA programmes should enable a grading of biomarkers (from experimental only to full evaluated) and of the laboratories in order to identify the significance of the test and to assess the level at which a laboratory could operate.

  7. Shotgun Proteomics and Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    W. Hayes McDonald

    2002-01-01

    Full Text Available Coupling large-scale sequencing projects with the amino acid sequence information that can be gleaned from tandem mass spectrometry (MS/MS has made it much easier to analyze complex mixtures of proteins. The limits of this “shotgun” approach, in which the protein mixture is proteolytically digested before separation, can be further expanded by separating the resulting mixture of peptides prior to MS/MS analysis. Both single dimensional high pressure liquid chromatography (LC and multidimensional LC (LC/LC can be directly interfaced with the mass spectrometer to allow for automated collection of tremendous quantities of data. While there is no single technique that addresses all proteomic challenges, the shotgun approaches, especially LC/LC-MS/MS-based techniques such as MudPIT (multidimensional protein identification technology, show advantages over gel-based techniques in speed, sensitivity, scope of analysis, and dynamic range. Advances in the ability to quantitate differences between samples and to detect for an array of post-translational modifications allow for the discovery of classes of protein biomarkers that were previously unassailable.

  8. Crevicular fluid biomarkers and periodontal disease progression.

    Science.gov (United States)

    Kinney, Janet S; Morelli, Thiago; Oh, Min; Braun, Thomas M; Ramseier, Christoph A; Sugai, Jim V; Giannobile, William V

    2014-02-01

    Assess the ability of a panel of gingival crevicular fluid (GCF) biomarkers as predictors of periodontal disease progression (PDP). In this study, 100 individuals participated in a 12-month longitudinal investigation and were categorized into four groups according to their periodontal status. GCF, clinical parameters and saliva were collected bi-monthly. Subgingival plaque and serum were collected bi-annually. For 6 months, no periodontal treatment was provided. At 6 months, patients received periodontal therapy and continued participation from 6 to 12 months. GCF samples were analysed by ELISA for MMP-8, MMP-9, Osteoprotegerin, C-reactive Protein and IL-1β. Differences in median levels of GCF biomarkers were compared between stable and progressing participants using Wilcoxon Rank Sum test (p = 0.05). Clustering algorithm was used to evaluate the ability of oral biomarkers to classify patients as either stable or progressing. Eighty-three individuals completed the 6-month monitoring phase. With the exception of GCF C-reactive protein, all biomarkers were significantly higher in the PDP group compared to stable patients. Clustering analysis showed highest sensitivity levels when biofilm pathogens and GCF biomarkers were combined with clinical measures, 74% (95% CI = 61, 86). Signature of GCF fluid-derived biomarkers combined with pathogens and clinical measures provides a sensitive measure for discrimination of PDP (ClinicalTrials.gov NCT00277745). © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

  9. Allergic asthma biomarkers using systems approaches

    Directory of Open Access Journals (Sweden)

    Gaurab eSircar

    2014-01-01

    Full Text Available Asthma is characterized by lung inflammation caused by complex interaction between the immune system and environmental factors such as allergens and inorganic pollutants. Recent research in this field is focused on discovering new biomarkers associated with asthma pathogenesis. This review illustrates updated research associating biomarkers of allergic asthma and their potential use in systems biology of the disease. We focus on biomolecules with altered expression, which may serve as inflammatory, diagnostic and therapeutic biomarkers of asthma discovered in human or experimental asthma model using genomic, proteomic and epigenomic approaches for gene and protein expression profiling. These include high-throughput technologies such as state of the art microarray and proteomics Mass Spectrometry (MS platforms. Emerging concepts of molecular interactions and pathways may provide new insights in searching potential clinical biomarkers. We summarized certain pathways with significant linkage to asthma pathophysiology by analyzing the compiled biomarkers. Systems approaches with this data can identify the regulating networks, which will eventually identify the key biomarkers to be used for diagnostics and drug discovery.

  10. Biomarkers in T cell therapy clinical trials

    Directory of Open Access Journals (Sweden)

    Kalos Michael

    2011-08-01

    Full Text Available Abstract T cell therapy represents an emerging and promising modality for the treatment of both infectious disease and cancer. Data from recent clinical trials have highlighted the potential for this therapeutic modality to effect potent anti-tumor activity. Biomarkers, operationally defined as biological parameters measured from patients that provide information about treatment impact, play a central role in the development of novel therapeutic agents. In the absence of information about primary clinical endpoints, biomarkers can provide critical insights that allow investigators to guide the clinical development of the candidate product. In the context of cell therapy trials, the definition of biomarkers can be extended to include a description of parameters of the cell product that are important for product bioactivity. This review will focus on biomarker studies as they relate to T cell therapy trials, and more specifically: i. An overview and description of categories and classes of biomarkers that are specifically relevant to T cell therapy trials, and ii. Insights into future directions and challenges for the appropriate development of biomarkers to evaluate both product bioactivity and treatment efficacy of T cell therapy trials.

  11. Biomarkers, Natural Course and Prognosis.

    Science.gov (United States)

    Arenillas, Juan F; López-Cancio, Elena; Wong, Ka Sing

    2016-01-01

    Increasing our knowledge about intracranial atherosclerosis (ICAS) natural history and prognostic factors is essential to improve its preventive therapy and thus reduce the dramatic clinical consequences caused by this entity. ICAS is characterized by a chronic and progressive course until it becomes symptomatic, mostly through complication of an unstable intracranial atherosclerotic plaque. Population-based studies in healthy subjects have shown that the prevalence of asymptomatic ICAS is higher in Asian than in Caucasian populations. In both settings, asymptomatic ICAS is associated with classical vascular risk factors and with the metabolic syndrome, and it is burdened with an increasing risk of having incident stroke and cognitive impairment. When it reaches its symptomatic stage, ICAS is a dynamic and aggressive condition, and affected patients are at high risk of having recurrent stroke and other major vascular events. The Stenting versus Aggressive Medical Therapy for Intracranial Arterial Stenosis (SAMMPRIS) trial has recently shown a robust impact of intensive medical therapy reducing the risk of clinical recurrence of symptomatic ICAS. However, even under best medical therapy and degree of risk factor control, symptomatic ICAS-related recurrence risk continues to be the highest among all stroke etiologic subtypes. The second part of the chapter reviews the current understanding of prognostic factors that may help discriminate the high-risk ICAS patients, divided into local factors (vulnerable ICAS plaque) and systemic factors (vulnerable ICAS patient). Regarding research on local factors, high-resolution magnetic resonance imaging (HRMRI) is an emerging technique that allows in vivo evaluation of intracranial arterial wall, which is displacing our research focus from intracranial stenosis degree towards intracranial atherosclerotic plaque composition and activity. Characterization of the vulnerable ICAS patient may be improved with biomarker research. The

  12. Protein biomarker enrichment by biomarker antibody complex elution for immunoassay biosensing

    NARCIS (Netherlands)

    Sabatté, G.S.; Feitsma, H.; Evers, T.H.; Prins, M.W.J.

    2011-01-01

    It is very challenging to perform sample enrichment for protein biomarkers because proteins can easily change conformation and denature. In this paper we demonstrate protein enrichment suited for high-sensitivity integrated immuno-biosensing. The method enhances the concentration of the biomarkers

  13. Validation of biomarkers of food intake − critical assessment of candidate biomarkers

    DEFF Research Database (Denmark)

    Dragsted, Lars Ove; Gao, Qian; Scalbert, Augustin

    2018-01-01

    Biomarkers of food intake (BFIs) are a promising tool for limiting misclassification in nutrition research where more subjective dietary assessment instruments are used. They may also be used to assess compliance to dietary guidelines or to a dietary intervention. Biomarkers therefore hold promis...

  14. Biology and Biomarkers for Wound Healing

    Science.gov (United States)

    Lindley, Linsey E.; Stojadinovic, Olivera; Pastar, Irena; Tomic-Canic, Marjana

    2016-01-01

    Background As the population grows older, the incidence and prevalence of conditions which lead to a predisposition for poor wound healing also increases. Ultimately, this increase in non-healing wounds has led to significant morbidity and mortality with subsequent huge economic ramifications. Therefore, understanding specific molecular mechanisms underlying aberrant wound healing is of great importance. It has, and will continue to be the leading pathway to the discovery of therapeutic targets as well as diagnostic molecular biomarkers. Biomarkers may help identify and stratify subsets of non-healing patients for whom biomarker-guided approaches may aid in healing. Methods A series of literature searches were performed using Medline, PubMed, Cochrane Library, and Internet searches. Results Currently, biomarkers are being identified using biomaterials sourced locally, from human wounds and/or systemically using systematic high-throughput “omics” modalities (genomic, proteomic, lipidomic, metabolomic analysis). In this review we highlight the current status of clinically applicable biomarkers and propose multiple steps in validation and implementation spectrum including those measured in tissue specimens e.g. β-catenin and c-myc, wound fluid e.g. MMP’s and interleukins, swabs e.g. wound microbiota and serum e.g. procalcitonin and MMP’s. Conclusions Identification of numerous potential biomarkers utilizing different avenues of sample collection and molecular approaches is currently underway. A focus on simplicity, and consistent implementation of these biomarkers as well as an emphasis on efficacious follow-up therapeutics is necessary for transition of this technology to clinically feasible point-of-care applications. PMID:27556760

  15. Male reproduction and environmental and occupational exposures: a review of epidemiologic methods Reproducción masculina y exposiciones ambientales u ocupacionales: una revisión de métodos epidemiológicos

    Directory of Open Access Journals (Sweden)

    Anne L. Golden

    1999-11-01

    Full Text Available Concerns that chemical exposures in the environment have been detrimental to male sexual development and fertility have been heightened by reports of declining sperm counts over the past 50 years. Marked geographic variation has been found in semen quality and in the incidence of testicular cancer and certain urogenital defects. Debate continues over the existence, magnitude and significance of these trends, and how best to evaluate the hypothesis that in utero and childhood exposures to estrogenic compounds may be to blame. Epidemiologic methods for assessing the impact of hazardous substances on male reproductive health have been developed mainly in the area of occupational medicine, and this paper will review the currently recommended methods. These include questionnaires to determine reproductive history and sexual function; reproductive hormone profiles; and semen analyses such as sperm concentration, motility, and morphology. New research tools that show significant promise from the fields of clinical reproductive medicine and reproductive toxicology are discussed as possible additions to epidemiologic studies, including assays of sperm function and genetic integrity, and biomarkers of DNA damage. For population-based studies involving occupational groups or communities with environmental exposures, issues related to the cost, validity, precision and utility of these methods must be carefully considered.Varios artículos publicados informan acerca de una declinación en la concentración de espermatozoides durante los últimos 50 años; lo anterior ha motivado una preocupación creciente en el sentido de que las exposiciones ambientales a diversos químicos actúen en detrimento del desarrollo sexual y de la fertilidad masculina. Se ha observado una marcada variación geográfica en la calidad del semen y en la incidencia del cáncer testicular y diversas malformaciones urogenitales. Persiste un debate acerca de la existencia, magnitud y

  16. Dietary and health biomarkers - time for an update

    DEFF Research Database (Denmark)

    Dragsted, Lars Ove; Gao, Qian; Pratico, Giulia

    2017-01-01

    for these biomarker classes, and no recent systematic review of all proposed biomarkers for food intake. While advanced databases exist for the human and food metabolomes, additional tools are needed to curate and evaluate current data on dietary and health biomarkers. The Food Biomarkers Alliance (FoodBAll) under......In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects of specific dietary components, and biomarkers to assess the effects of diet on health...... much mechanistic insight into the effects of food components and diets. Although hundreds of papers in nutrition are published annually, there is no current ontology for the area, no generally accepted classification terminology for biomarkers in nutrition and health, no systematic validation scheme...

  17. Nanomaterials based biosensors for cancer biomarker detection

    International Nuclear Information System (INIS)

    Malhotra, Bansi D; Kumar, Saurabh; Pandey, Chandra Mouli

    2016-01-01

    Biosensors have enormous potential to contribute to the evolution of new molecular diagnostic techniques for patients suffering with cancerous diseases. A major obstacle preventing faster development of biosensors pertains to the fact that cancer is a highly complex set of diseases. The oncologists currently rely on a few biomarkers and histological characterization of tumors. Some of the signatures include epigenetic and genetic markers, protein profiles, changes in gene expression, and post-translational modifications of proteins. These molecular signatures offer new opportunities for development of biosensors for cancer detection. In this context, conducting paper has recently been found to play an important role towards the fabrication of a biosensor for cancer biomarker detection. In this paper we will focus on results of some of the recent studies obtained in our laboratories relating to fabrication and application of nanomaterial modified paper based biosensors for cancer biomarker detection. (paper)

  18. Using Aptamers for Cancer Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    Yun Min Chang

    2013-01-01

    Full Text Available Aptamers are single-stranded synthetic DNA- or RNA-based oligonucleotides that fold into various shapes to bind to a specific target, which includes proteins, metals, and molecules. Aptamers have high affinity and high specificity that are comparable to that of antibodies. They are obtained using iterative method, called (Systematic Evolution of Ligands by Exponential Enrichment SELEX and cell-based SELEX (cell-SELEX. Aptamers can be paired with recent advances in nanotechnology, microarray, microfluidics, and other technologies for applications in clinical medicine. One particular area that aptamers can shed a light on is biomarker discovery. Biomarkers are important in diagnosis and treatment of cancer. In this paper, we will describe ways in which aptamers can be used to discover biomarkers for cancer diagnosis and therapeutics.

  19. Biomarkers in pancreatic adenocarcinoma: current perspectives.

    Science.gov (United States)

    Swords, Douglas S; Firpo, Matthew A; Scaife, Courtney L; Mulvihill, Sean J

    2016-01-01

    Pancreatic ductal adenocarcinoma (PDAC) has a poor prognosis, with a 5-year survival rate of 7.7%. Most patients are diagnosed at an advanced stage not amenable to potentially curative resection. A substantial portion of this review is dedicated to reviewing the current literature on carbohydrate antigen (CA 19-9), which is currently the only guideline-recommended biomarker for PDAC. It provides valuable prognostic information, can predict resectability, and is useful in decision making about neoadjuvant therapy. We also discuss carcinoembryonic antigen (CEA), CA 125, serum biomarker panels, circulating tumor cells, and cell-free nucleic acids. Although many biomarkers have now been studied in relation to PDAC, significant work still needs to be done to validate their usefulness in the early detection of PDAC and management of patients with PDAC.

  20. Oral Metagenomic Biomarkers in Rheumatoid Arthritis

    Science.gov (United States)

    2017-09-01

    individuals with rheumatoid arthritis (RA). The goal is to test the  hypothesis that oral microbiome and metagenomic analyses will allow  us  to identify new...biomarkers  that are  useful  for the diagnosis of early RA and/or biomarkers that help to predict the efficacy of  specific therapeutic interventions... RNA  microbiome analysis as well as whole genome shotgun sequencing.  Upon completion of these aims, any identified bacterial biomarkers may be

  1. Biomarkers in the evolution of multiple sclerosis.

    Science.gov (United States)

    Berger, Thomas

    2017-11-01

    Nonimaging biomarkers can be applied in differential diagnosis, evaluation of disease progression and therapy monitoring of multiple sclerosis (MS). Presence of oligoclonal IgG bands in cerebrospinal fluid is a diagnostic element and a negative predictor of MS evolution. AQP4 antibodies are pathogenic and diagnostic for neuromyelitis optica spectrum disorder. Antibodies to myelin oligodendrocyte glycoprotein develop in about 50% of predominantly pediatric patients with acute disseminated encephalomyelitis, but their possible role in pathogenesis is unknown. Currently, there are no individualized biomarkers suitable to track disease progression. Neutralizing antibodies against IFN-β, natalizumab and daclizumab arise with variable frequency and reduce treatment efficacy. The anti-John Cunningham virus antibody index has potential as a biomarker for risk of progressive multifocal leukoencephalopathy.

  2. Other biomarkers for detecting prostate cancer.

    Science.gov (United States)

    Nogueira, Lucas; Corradi, Renato; Eastham, James A

    2010-01-01

    Prostate-specific antigen (PSA) has been used for detecting prostate cancer since 1994. Although it is the best cancer biomarker available, PSA is not perfect. It lacks both the sensitivity and specificity to accurately detect the presence of prostate cancer. None of the PSA thresholds currently in use consistently identify patients with prostate cancer and exclude patients without cancer. Novel approaches to improve our ability to detect prostate cancer and predict the course of the disease are needed. Additional methods for detecting prostate cancer have been evaluated. Despite the discovery of many new biomarkers, only a few have shown some clinical value. These markers include human kallikrein 2, urokinase-type plasminogen activator receptor, prostate-specific membrane antigen, early prostate cancer antigen, PCA3, alpha-methylacyl-CoA racemase and glutathione S-transferase pi hypermethylation. We review the reports on biomarkers for prostate cancer detection, and their possible role in the clinical practice.

  3. Molecular biomarkers in idiopathic pulmonary fibrosis

    Science.gov (United States)

    Ley, Brett; Brown, Kevin K.

    2014-01-01

    Molecular biomarkers are highly desired in idiopathic pulmonary fibrosis (IPF), where they hold the potential to elucidate underlying disease mechanisms, accelerated drug development, and advance clinical management. Currently, there are no molecular biomarkers in widespread clinical use for IPF, and the search for potential markers remains in its infancy. Proposed core mechanisms in the pathogenesis of IPF for which candidate markers have been offered include alveolar epithelial cell dysfunction, immune dysregulation, and fibrogenesis. Useful markers reflect important pathological pathways, are practically and accurately measured, have undergone extensive validation, and are an improvement upon the current approach for their intended use. The successful development of useful molecular biomarkers is a central challenge for the future of translational research in IPF and will require collaborative efforts among those parties invested in advancing the care of patients with IPF. PMID:25260757

  4. Biomarkers for CNS involvement in pediatric lupus

    Science.gov (United States)

    Rubinstein, Tamar B; Putterman, Chaim; Goilav, Beatrice

    2015-01-01

    CNS disease, or central neuropsychiatric lupus erythematosus (cNPSLE), occurs frequently in pediatric lupus, leading to significant morbidity and poor long-term outcomes. Diagnosing cNPSLE is especially difficult in pediatrics; many current diagnostic tools are invasive and/or costly, and there are no current accepted screening mechanisms. The most complicated aspect of diagnosis is differentiating primary disease from other etiologies; research to discover new biomarkers is attempting to address this dilemma. With many mechanisms involved in the pathogenesis of cNPSLE, biomarker profiles across several modalities (molecular, psychometric and neuroimaging) will need to be used. For the care of children with lupus, the challenge will be to develop biomarkers that are accessible by noninvasive measures and reliable in a pediatric population. PMID:26079959

  5. Emerging biomarkers for cancer immunotherapy in melanoma.

    Science.gov (United States)

    Axelrod, Margaret L; Johnson, Douglas B; Balko, Justin M

    2017-09-14

    The treatment and prognosis of metastatic melanoma has changed substantially since the advent of novel immune checkpoint inhibitors (ICI), agents that enhance the anti-tumor immune response. Despite the success of these agents, clinically actionable biomarkers to aid patient and regimen selection are lacking. Herein, we summarize and review the evidence for candidate biomarkers of response to ICIs in melanoma. Many of these candidates can be examined as parts of a known molecular pathway of immune response, while others are clinical in nature. Due to the ability of ICIs to illicit dramatic and durable responses, well-validated biomarkers that can be effectively implemented in the clinic will require strong negative predictive values that do not limit patients with who may benefit from ICI therapy. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Estratificación epidemiológica en el control de los factores de riesgo de la tuberculosis Epidemiological stratification to control the risk factors of tuberculosis

    Directory of Open Access Journals (Sweden)

    Elba Nieves Moreno Díaz

    2011-12-01

    Full Text Available Se realizó un estudio descriptivo longitudinal, con el objetivo de implementar la estratificación epidemiológica en el control de los factores de riesgo de la tuberculosis, provincia Pinar del Río, 2008-2010. El universo de estudio lo constituyó, los habitantes de la provincia en cada uno de los años estudiados. Se revisó el registro de dispensarización y las encuestas epidemiológicas; de ellos se obtuvieron los factores de riesgo: alcoholismo, hábito de fumar, diabetes mellitus, ancianos solos, desnutrición, inmunodeprimidos y casos viviendo con VIH/Sida. Para el procesamiento de la información se trabajó con Microsoft Excel y MapInfo Professional. Se utilizó la metodología estratificación epidemiológica de riesgo hasta nivel municipal; los estratos para los factores de riesgo como para la enfermedad, se clasificaron en: muy alto, alto, mediano y bajo riesgo. Para determinar la significación de cambios se utilizó la prueba Mc Nemar. Los resultados mostraron que en el 2009, el 50% de los municipios que en la estratificación del 2008 estaban en el estrato de muy alto y alto riesgo, el 85,7% cambiaran de estratos, lo que indica un mejor control de los factores de riesgo. El proceso de estratificación en el 2010, no logró cambios favorables en los municipios con mayor riesgo en el 2008, estando el 65% clasificado en estratos de muy alto y alto riesgo, pues el plan de acción previsto, no fue ejecutado con efectividad y seriedad por los jefes de programa, debido a inestabilidad y ausencia de los mismos en los municipios de mayor riesgo.A descriptive, longitudinal study aimed at implementing epidemiological stratification to control the risk factors of tuberculosis in Pinar del Rio province was carried out form 2008 to 2010. The target group was comprised of the inhabitants of the province for each of the years under study. Records and epidemiological survey were revised; taking into account the risk factors of alcoholism

  7. Biomarkers and Targeted Therapy in Pancreatic Cancer

    Directory of Open Access Journals (Sweden)

    Fataneh Karandish

    2016-01-01

    Full Text Available Pancreatic ductal adenocarcinoma (PDAC constitutes 90% of pancreatic cancers. PDAC is a complex and devastating disease with only 1%–3% survival rate in five years after the second stage. Treatment of PDAC is complicated due to the tumor microenvironment, changing cell behaviors to the mesenchymal type, altered drug delivery, and drug resistance. Considering that pancreatic cancer shows early invasion and metastasis, critical research is needed to explore different aspects of the disease, such as elaboration of biomarkers, specific signaling pathways, and gene aberration. In this review, we highlight the biomarkers, the fundamental signaling pathways, and their importance in targeted drug delivery for pancreatic cancers.

  8. Biomarkers and Targeted Therapy in Pancreatic Cancer.

    Science.gov (United States)

    Karandish, Fataneh; Mallik, Sanku

    2016-01-01

    Pancreatic ductal adenocarcinoma (PDAC) constitutes 90% of pancreatic cancers. PDAC is a complex and devastating disease with only 1%-3% survival rate in five years after the second stage. Treatment of PDAC is complicated due to the tumor microenvironment, changing cell behaviors to the mesenchymal type, altered drug delivery, and drug resistance. Considering that pancreatic cancer shows early invasion and metastasis, critical research is needed to explore different aspects of the disease, such as elaboration of biomarkers, specific signaling pathways, and gene aberration. In this review, we highlight the biomarkers, the fundamental signaling pathways, and their importance in targeted drug delivery for pancreatic cancers.

  9. Biomarkers of multiorgan injury in neonatal encephalopathy.

    Science.gov (United States)

    Aslam, Saima; Molloy, Eleanor J

    2015-01-01

    Neonatal encephalopathy (NE) is a major contributor to neurodevelopmental deficits including cerebral palsy in term and near-term infants. The long-term neurodevelopmental outcome is difficult to predict with certainty in first few days of life. Multiorgan involvement is common but not part of the diagnostic criteria for NE. The most frequently involved organs are the heart, liver, kidneys and hematological system. Cerebral and organ involvement is associated with the release of organ specific biomarkers in cerebrospinal fluid, urine and blood. These biomarkers may have a role in the assessment of the severity of asphyxia and long-term outcome in neonates with NE.

  10. Biomarkers of necrotising soft tissue infections

    DEFF Research Database (Denmark)

    Hansen, Marco Bo; Simonsen, Ulf; Garred, Peter

    2015-01-01

    INTRODUCTION: The mortality and amputation rates are still high in patients with necrotising soft tissue infections (NSTIs). It would be ideal to have a set of biomarkers that enables the clinician to identify high-risk patients with NSTI on admission. The objectives of this study are to evaluate...... and mortality in patients with NSTI and that HBOT reduces the inflammatory response. METHODS AND ANALYSIS: This is a prospective, observational study being conducted in a tertiary referral centre. Biomarkers will be measured in 114 patients who have been operatively diagnosed with NSTI. On admission, baseline...

  11. Perfil epidemiológico de los eventos atendidos en prácticas asistenciales de fisioterapia de una institución universitaria en el año 2013

    OpenAIRE

    Sandoval-Cuellar, Carolina; Cobo-Mejía, Elisa Andrea

    2016-01-01

    Introducción: La epidemiología busca reconocer los eventos de salud-enfermedad en un grupo humano, así permite a través de perfiles epidemiológicos caracterizar poblaciones objeto de atención desde tipologías sociodemográficas, de atención y condiciones de salud. Objetivo: Describir el perfil epidemiológico de los eventos que se atienden en las prácticas asistenciales de 8 y 9 semestres de Fisioterapia de una Institución de Educación Superior en el año 2013. Metodología: Estudio observacional...

  12. Características clínicas y epidemiológicas de pacientes que consultan por acné

    Directory of Open Access Journals (Sweden)

    Fatima Agüero de Zaputovich

    2015-04-01

    Full Text Available El acné es una enfermedad multifactorial que afecta a más de 40 millones de personas a nivel mundial. A pesar de ser uno de los motivos más frecuente de consulta dermatológica, se carece a nivel nacional de estudios epidemiológicos sobre esta afección. El objetivo del estudio fue describir las características clínico-epidemiológicas de los pacientes que consultaron por acné en la Cátedra de Dermatología del Hospital de Clínicas de marzo a julio de 2013. En este estudio observacional, descriptivo de corte transversal se incluyeron en forma consecutiva 130 pacientes con acné, edad media: 20,3±5,5 años, 62,3% de sexo femenino, y >90% era procedente de Asunción o Departamento Central. El 65,3% reportó antecedentes familiares de acné y la edad de inicio fue más temprana en hombres. La ingesta de grasas fue el factor desencadenante más citado por los hombres, mientras que en las mujeres fue el periodo menstrual. El 63,15% de las mujeres que ingería anticonceptivos refirieron mejoría del acné. Un alto porcentaje (60% de mujeres presentó acné leve a moderado mientras que el acné severo a muy severo fue más frecuente (65% en los hombres. Los pacientes con acné leve tuvieron en promedio edades mayores (23±7,4 años que aquellos con acné severo (18±3,7 años. No se encontró asociación entre la presencia de antecedentes familiares, tabaquismo, irregularidades menstruales, fototipo cutáneo, índice de masa corporal y severidad del acné. Estos resultados pueden servir de base para futuras investigaciones y el establecimiento de protocolos diagnósticos y terapéuticos en el país.

  13. Perfil epidemiológico da tuberculose no município de São Paulo de 2006 a 2013

    Directory of Open Access Journals (Sweden)

    Priscila Fernanda Porto Scaff Pinto

    Full Text Available RESUMO: Introdução: A tuberculose é um grave problema de saúde que ainda persiste no mundo e no Brasil. O município de São Paulo é considerado prioritário para o controle da doença. Objetivo: Descrever o perfil epidemiológico de todos os casos novos de tuberculose no município de São Paulo notificados entre os anos de 2006 e 2013. Métodos: As variáveis selecionadas para o estudo foram as socioeconômicas, demográficas e as clínico-epidemiológicas obtidas através do sistema de informação online TB-WEB. Foi realizada uma análise descritiva dos dados e feita a comparação entre os anos. Para estudo da série histórica realizou-se análise de tendência linear. Um mapa temático foi confeccionado para visualizar a distribuição da doença no espaço urbano da cidade. Resultados e discussão: Houve um aumento da taxa de incidência-ano da tuberculose em menores de 15 anos e em moradores de rua. A taxa de cura melhorou, bem como a proporção de realização do tratamento supervisionado e a proporção dos diagnósticos feitos pela Atenção Básica. A doença está desigualmente distribuída no espaço do município, sendo que há distritos administrativos que não estão conseguindo progredir com relação ao seu controle. Conclusão: O programa municipal de controle da tuberculose necessita envidar esforços para os grupos vulneráveis para a tuberculose identificados e para as regiões da cidade com maior taxa de incidência-ano da doença.

  14. Panorama epidemiológico de exposición a plaguicidas inhibidores de colinesterasa en 17 departamentos del país

    Directory of Open Access Journals (Sweden)

    Marcela Varona

    1998-03-01

    Full Text Available Los organofosforados y carbamatos son los responsables de la mayor parte de intoxicaciones por plaguicidas que se presentan en el país; son potentes inhibidores de la enzima acetilcolinesterasa, causando graves intoxicaciones agudas de tipo laboral como también efectos a largo plazo. Ante esta problemática, en 1982, el lnstituto Nacional de Salud (INS, a través del Laboratorio de Salud Ambiental creó el Programa de Vigilancia Epidemiológica de plaguicidas organofosforados y carbamatos (VEO, empleando el método Lovibond para la determinación de la acetilcolinesterasa (ACHE como indicador, con el fin de detectar precozmente los casos de absorción elevada de plaguicidas. A partir de 1993, se cuenta con información de 17 departamentos del país, datos que se analizaron La totalidad de las personas que participó en el estudio de 1993 a 1995 fueron 41.899, las cuales tenían antecedentes de exposición a plaguicidas organofosforados o carbamatos. El 80% de los trabajadores que ingresaron al estudio pertenecían al género masculino, siendo el grupo de edad más afectado el de 18 a 40 años. Las mayores prevalencias de anormalidad para ACHE, según actividad económica, fue para la aplicación urbana y en relación a los oficios, para mezclador-tanqueador-formulador. Con relación a la seguridad social de 23.917 trabajadores, tan sólo 31,7% se encontraba afiliada a entidades de este tipo. Los datos obtenidos permitieron establecer el panorama epidemiológico de la intoxicación por plaguicidas inhibidores de colinesterasa, determinando la población de mayor riesgo, lo que conllevará a plantear nuevos estudios de investigación en esta población.

  15. Pressão arterial e discriminação interpessoal: revisão sistemática de estudos epidemiológicos

    Directory of Open Access Journals (Sweden)

    Paulo Francisco Couto

    2012-10-01

    Full Text Available A relação entre pressão arterial e discriminação tem sido investigada recentemente, havendo intensos debates na literatura sobre o tema. Este trabalho objetivou atualizar as revisões de literatura sobre discriminação e pressão arterial ou hipertensão. Foi conduzida pesquisa no PubMed, entre janeiro/2000 e dezembro/2010, incluindo estudos epidemiológicos, que avaliaram a discriminação interpessoal e sua relação com pressão arterial/hipertensão. Os 22 estudos identificados originaram-se dos Estados Unidos; 96% deles empregaram o delineamento transversal, com amostras de conveniência e compostas, em 59% dos casos, exclusivamente por negros. Os instrumentos mais utilizados para aferir discriminação foram Everyday Discrimination Scale e Perceived Racism Scale, enfatizando a discriminação étnico-racial, ocorrida ao longo da vida ou cotidianamente. Nos 22 estudos avaliados, a relação entre discriminação e os desfechos foi analisada 50 vezes. Em 20 (40% resultados, não foi encontrada qualquer associação e, em apenas 15 (30%, observaram-se associações positivas globais, sendo 67% destas estatisticamente significativas. Foram também observadas oito associações inversas, sugerindo que maior exposição à discriminação estaria associada com menor pressão arterial/hipertensão. Os estudos não permitiram apoiar consistentemente a hipótese de que a discriminação está associada à maior pressão arterial. Isto pode ser atribuído, em parte, às limitações dos estudos, relacionadas à mensuração da discriminação e de eventos que podem modificar sua associação com os desfechos. Para consolidar a discriminação como um fator de risco epidemiológico, é necessário utilizar estratégias metodológicas mais rigorosas e revisar os marcos teóricos que propõem relações de causa e efeito entre discriminação e pressão arterial.

  16. Dermatitis de contacto profesional, estudio clínico-epidemiológico entre los años 2011 y 2015

    Directory of Open Access Journals (Sweden)

    Daniela Subiabre-Ferrer

    Full Text Available Introducción: Las dermatitis de contacto son una de las formas más frecuentes de enfermedades profesionales en Europa, representado una importante carga económica para el empleador y el Estado. Objetivos: El objetivo de nuestro trabajo es describir las características clínico-epidemiológicas de los pacientes con dermatitis de contacto profesional (DCP, con el fin de identificar las diferentes poblaciones afectas, los productos mayormente relacionados y su evolución en el tiempo. Material y método: Se realizó un estudio clínico-epidemiológico retrospectivo en el que se analizaron 1213 pacientes estudiados con pruebas epicutáneas en la unidad de alergia cutánea del servicio de Dermatología del Hospital General Universitario de Valencia, entre los años 2011 y 2015. Todos los pacientes fueron estudiados con la serie estándar española del GEIDAC, con el que se realizaron lecturas en los días D2 y D4. Las respuestas se valoraron de acuerdo con la escala internacional de ICDRG. Resultados: Se observó una incidencia media de DCP del 10,1%. El 73,2% de los pacientes presentaban una Dermatitis alérgica de contacto (DAC. El 100% presentaron clínica de eccema, con un 91,9% en manos. El 60,2% de los pacientes eran trabajadores de los servicios de restauración y comercio, servicio de salud y cuidados. Los conservantes fueron los alérgenos más frecuentes (37,8%, entre los que destacan las isotiazolinonas (91,2%. Los principales agentes irritantes han sido el agua y los detergentes, así como guantes y antisépticos. Discusión: Se ha observado un predominio femenino y en población joven. Las profesiones afectadas más frecuentemente son las esteticistas, peluqueras, personal de hostelería y limpieza, en las que el diagnóstico más corriente es el de DAC. En los profesionales sanitarios predomina la dermatitis de contacto irritativa y la manipulación de alimentos es el principal factor de riesgo de la dermatitis de contacto proteínica.

  17. Método de captura e recaptura: nova metodologia para pesquisas epidemiológicas Capture-recapture: a new methodology for epidemiological research

    Directory of Open Access Journals (Sweden)

    John Dunn

    1994-12-01

    Full Text Available O método de captura e recaptura, embora não seja novo, tem sido pouco usado em estudos epidemiológicos. Trata-se de método bem adaptável e adequado para estudar populações incomuns ou esquivas, como usuários de drogas endovenosas. Tem sido usado para estudar populações diversas como prostitutas que trabalham na rua ou volume de células vermelhas no homem. Permite ainda estimar a incidência e a prevalência de doenças de forma mais precisa do que os métodos tradicionais e com uma melhor relação custo-benefício. Devido à sua relevância dentro do campo da epidemiologia, decidiu-se realizar uma revisão sobre esse método, enfocando a história, as principais aplicações e apontando as suposições teóricas que o fundamentam. Seu potencial para futuras pesquisas epidemiológicas é promissor.Although capture-recapture method is not new, their use in epidemiological studies has so far been limited. The method was developed by animal ecologists to estimate the size of various species populations, but in recent years it has been used to measure the incidence and prevalence of a variety of non-communicable diseases. Capture-recapture allows more accurate estimates to be made than is the case with traditional methods and is more cost-effective. The method is ideally suited to studying rare or elusive populations, such as intravenous drug misusers; but they are highly adaptable and have been used to study populations as diverse as street working prostitutes and the human red-cell volume. The objectives of this review are to explain the mathematical theory behind capture-recapture, give examples of its use and application in clinical epidemiology and out line some of the modifications that have been made to the theory, which take into account the complex nature of samples used in clinical research. An increasing number of medical epidemoilogists have started to use the method, and its potencial for future epidemiological research is

  18. Tratamiento estadístico de la falta de respuesta en estudios epidemiológicos transversales Statistical processing of non-response in transversal epidemiological studies

    Directory of Open Access Journals (Sweden)

    Eduardo Carracedo-Martínez

    2006-08-01

    Full Text Available En los estudios epidemiológicos, la falta de respuestas constituye una gran limitación por la pérdida de validez y el poder estadístico que implica, sea que se produzca en forma de participación parcial (el sujeto deja alguna pregunta sin contestar o como ausencia de participación (el individuo no contesta ninguna pregunta. En este trabajo se realiza una revisión de la bibliografía científica sobre los distintos métodos para realizar un tratamiento estadístico de los datos cuando no se obtienen respuestas; la finalidad es contrarrestar las limitaciones de la información, siempre en el caso de estudios epidemiológicos no longitudinales. La mayor parte de los métodos estadísticos se centra en el tratamiento de la participación parcial (datos faltantes y puede clasificarse en dos grandes grupos: de asignación y de datos completos. La elección correcta del método para un estudio requiere un análisis previo de la matriz de los datos, en relación con el mecanismo de generación de datos faltantes y el porcentaje del total de los datos que representa.In epidemiological surveys, non-response constitutes a great limitation due to the loss of validity and statistical power it represents, whether such a loss occurs due to partial participation (the individual fails to answer certain variables or due to total lack of participation (the individual does not answer any variable. This paper reviews the scientific literature on the different methods to process statistic data when non-response has occurred in non-longitudinal studies, so as to counteract their effect in such studies. Most statistical methods focus on dealing with partial participation (missing data. These methods, of which there is a great variety, can be classified into two large groups: imputation and complete data. For accurate selection of the study method, it is necessary to study the data matrix beforehand, observing the missing data generation mechanism, as well as the

  19. Características clínico-epidemiológicas de pacientes con cólera en la ciudad de México

    Directory of Open Access Journals (Sweden)

    Vilchis-Guizar Agustina Elena

    1999-01-01

    Full Text Available OBJETIVO: Comparar las características clínico-epidemiológicas de enfermos de cólera (casos con las de pacientes con diarrea por otra causa (no casos, atendidos en las unidades médicas de la Delegación 2 Noreste del Distrito Federal, del Instituto Mexicano del Seguro Social (IMSS. MATERIAL Y MÉTODOS: Se realizó un estudio transversal analítico y se utilizaron datos de 4 952 notificaciones reunidas entre 1995 y 1998 a través del formato oficial "Hoja de notificación inmediata de casos de cólera", que cada unidad médica envía a la Coordinación de Salud Comunitaria del IMSS. Mediante estadística analítica se compararon medias y proporciones para ambos grupos. RESULTADOS: Se identificaron 588 pacientes con cólera y 4 364 con diarrea por otra causa. En el primer grupo, la edad promedio varió entre los 39 y los 51 años, y predominó el sexo femenino (54%. Durante 1995 y 1997 (años en los que se presentó un número más elevado de casos, los pacientes de cólera, en relación con el grupo de comparación, presentaron una mayor frecuencia de evacuaciones líquidas (97 vs. 73%, con aspecto de "agua de arroz" (31 vs. 13%, vómitos (72 vs. 63%, espasmos musculares (49 vs. 26%, deshidratación (83 vs. 71%, choque hipovolémico (10 vs. 1% y defunciones (0.85% vs. 0.25%, con diferencias estadísticamente significativas. CONCLUSIONES: El cólera muestra un comportamiento cíclico bianual; a mayor frecuencia mayor gravedad de la enfermedad. Se requiere incrementar la vigilancia epidemiológica y el esfuerzo médico para un diagnóstico y tratamiento oportuno.

  20. De Novo Identification of Biomarker Proteins Using Tandem Mass Spectrometry

    Science.gov (United States)

    Many studies have shown that biological fluids contain an important number of biomarkers associated with various pathologies. For instance, there has been extensive research to identify effective biomarkers as prognostic indicators of breast cancer. An effective approach for biom...

  1. Immune biomarkers in the spectrum of childhood noncommunicable diseases

    NARCIS (Netherlands)

    Skevaki, Chrysanthi; Van Den Berg, Jolice; Jones, Nicholas; Garssen, Johan; Vuillermin, Peter; Levin, Michael; Landay, Alan; Renz, Harald; Calder, Philip C.; Thornton, Catherine A.

    2016-01-01

    A biomarker is an accurately and reproducibly quantifiable biological characteristic that provides an objective measure of health status or disease. Benefits of biomarkers include identification of therapeutic targets, monitoring of clinical interventions, and development of personalized (or

  2. Biomarker Detection using PS2-Thioaptamers, Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — AM Biotechnologies (AM) will develop a system to detect and quantify bone demineralization biomarkers as outlined in SBIR Topic "Technologies to Detect Biomarkers"....

  3. Molecular Biomarkers: Their significance and application in marine pollution monitoring

    Digital Repository Service at National Institute of Oceanography (India)

    Sarkar, A.; Ray, D.; Shrivastava, A.N.; Sarkar, S.

    worldwide. Among the various types of biomarkers, the following have received special attention: cytochrome P4501A induction, DNA integrity, acetylcholinesterase activity and metallothionein induction. These biomarkers are being used to evaluate exposure...

  4. Identificação de áreas de estratificação epidemiológica no foco de oncocercose na região Yanomami, Roraima, Brasil

    Directory of Open Access Journals (Sweden)

    Giovanini Evelim Coelho

    1998-07-01

    Full Text Available No presente trabalho, visando a um adequado planejamento, análise e acompanhamento do Programa de Tratamento, Controle e Eliminação da Oncocercose Humana no Brasil, foram estudadas 27 áreas geográficas e examinados 3.974 indivíduos. Assim, foram identificadas e estratificadas quatro áreas epidemiológicas, tendo por base as prevalências diferenciadas em cada uma delas.

  5. Identificação de áreas de estratificação epidemiológica no foco de oncocercose na região Yanomami, Roraima, Brasil

    Directory of Open Access Journals (Sweden)

    Coelho Giovanini Evelim

    1998-01-01

    Full Text Available No presente trabalho, visando a um adequado planejamento, análise e acompanhamento do Programa de Tratamento, Controle e Eliminação da Oncocercose Humana no Brasil, foram estudadas 27 áreas geográficas e examinados 3.974 indivíduos. Assim, foram identificadas e estratificadas quatro áreas epidemiológicas, tendo por base as prevalências diferenciadas em cada uma delas.

  6. Challenging homeostasis to define biomarkers for nutrition related health

    NARCIS (Netherlands)

    Ommen, van B.; Keijer, J.; Heil, S.G.; Kaput, J.

    2009-01-01

    A primary goal of nutrition research is to optimize health and prevent or delay disease. Biomarkers to quantify health optimization are needed since many if not most biomarkers are developed for diseases. Quantifying normal homeostasis and developing validated biomarkers are formidable tasks because

  7. Biomarkers: Delivering on the expectation of molecularly driven, quantitative health.

    Science.gov (United States)

    Wilson, Jennifer L; Altman, Russ B

    2018-02-01

    Biomarkers are the pillars of precision medicine and are delivering on expectations of molecular, quantitative health. These features have made clinical decisions more precise and personalized, but require a high bar for validation. Biomarkers have improved health outcomes in a few areas such as cancer, pharmacogenetics, and safety. Burgeoning big data research infrastructure, the internet of things, and increased patient participation will accelerate discovery in the many areas that have not yet realized the full potential of biomarkers for precision health. Here we review themes of biomarker discovery, current implementations of biomarkers for precision health, and future opportunities and challenges for biomarker discovery. Impact statement Precision medicine evolved because of the understanding that human disease is molecularly driven and is highly variable across patients. This understanding has made biomarkers, a diverse class of biological measurements, more relevant for disease diagnosis, monitoring, and selection of treatment strategy. Biomarkers' impact on precision medicine can be seen in cancer, pharmacogenomics, and safety. The successes in these cases suggest many more applications for biomarkers and a greater impact for precision medicine across the spectrum of human disease. The authors assess the status of biomarker-guided medical practice by analyzing themes for biomarker discovery, reviewing the impact of these markers in the clinic, and highlight future and ongoing challenges for biomarker discovery. This work is timely and relevant, as the molecular, quantitative approach of precision medicine is spreading to many disease indications.

  8. Biomarkører for anorexia nervosa

    DEFF Research Database (Denmark)

    Sjögren, Magnus

    2017-01-01

    Biomarkers for anorexia nervosa (AN) which reflect the pathophysiology and relate to the aetiology of the disease, are warranted and could bring us one step closer to targeted treatment of AN. Some leads may be found in the biochemistry which often is found disturbed in AN, although normalization...

  9. Plasma inflammatory biomarkers response to aerobic versus ...

    African Journals Online (AJOL)

    Plasma inflammatory biomarkers response to aerobic versus resisted exercise training for chronic obstructive pulmonary disease patients. ... Recent studies proved that morbidity and mortality of COPD is related to systemic inflammation as it contributes to the pathogenesis of atherosclerosis and cardiovascular disease.

  10. Stratum corneum biomarkers for inflammatory skin diseases

    NARCIS (Netherlands)

    Koppes, S.A.

    2017-01-01

    This thesis focusses on development of biomarkers, obtained by a non-invasive sampling method, for skin inflammatory diseases relevant for occupational settings; irritant contact dermatitis (ICD), allergic contact dermatitis (ACD) and atopic dermatitis (AD). In various studies, in which different

  11. Cerebrospinal fluid biomarkers for Parkinson's disease

    DEFF Research Database (Denmark)

    Dammann Andersen, Andreas; Binzer, Michael; Stenager, Egon

    2017-01-01

    Diagnosticering af Parkinson's sygdom (PD) er baseret på den kliniske udvikling af sygdommen samt en fysisk undersøgelse af patienten, men fejldiagnosticering sker hyppigt; specielt i tidlige stadier. Biomarkører for PD kan muliggøre en tidligere og mere præcis diagnosticering samt monitorering a...

  12. Biomarkers of problem drinking in homeless patients

    DEFF Research Database (Denmark)

    Hesse, Morten; Thiesen, Henrik

    2010-01-01

    Objective. In the search for optimal biomarkers of excessive drinking, a central limitation has been the lack of sensitivity of measures. Many patients have apparently normal values of liver markers despite a considerable alcohol intake. This study aimed to test a novel combined indicator...

  13. Biomarkers in pancreatic adenocarcinoma: current perspectives

    Directory of Open Access Journals (Sweden)

    Swords DS

    2016-12-01

    Full Text Available Douglas S Swords, Matthew A Firpo, Courtney L Scaife, Sean J Mulvihill Department of Surgery, University of Utah Health Sciences, Salt Lake City, UT, USA Abstract: Pancreatic ductal adenocarcinoma (PDAC has a poor prognosis, with a 5-year survival rate of 7.7%. Most patients are diagnosed at an advanced stage not amenable to potentially curative resection. A substantial portion of this review is dedicated to reviewing the current literature on carbohydrate antigen (CA 19-9, which is currently the only guideline-recommended biomarker for PDAC. It provides valuable prognostic information, can predict resectability, and is useful in decision making about neoadjuvant therapy. We also discuss carcinoembryonic antigen (CEA, CA 125, serum biomarker panels, circulating tumor cells, and cell-free nucleic acids. Although many biomarkers have now been studied in relation to PDAC, significant work still needs to be done to validate their usefulness in the early detection of PDAC and management of patients with PDAC. Keywords: pancreatic cancer, biomarkers, screening, CA 19-9, CEA

  14. Quantitative multiplex detection of pathogen biomarkers

    Energy Technology Data Exchange (ETDEWEB)

    Mukundan, Harshini; Xie, Hongzhi; Swanson, Basil I.; Martinez, Jennifer; Grace, Wynne K.

    2016-02-09

    The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.

  15. Quantitative multiplex detection of pathogen biomarkers

    Science.gov (United States)

    Mukundan, Harshini; Xie, Hongzhi; Swanson, Basil I; Martinez, Jennifer; Grace, Wynne K

    2014-10-14

    The present invention addresses the simultaneous detection and quantitative measurement of multiple biomolecules, e.g., pathogen biomarkers through either a sandwich assay approach or a lipid insertion approach. The invention can further employ a multichannel, structure with multi-sensor elements per channel.

  16. BLOOD BIOMARKERS FOR EVALUATION OF PERINATAL ENCEPHALOPATHY

    Directory of Open Access Journals (Sweden)

    Ernest Marshall Graham

    2016-07-01

    Full Text Available Recent research in identification of brain injury after trauma shows many possible blood biomarkers that may help identify the fetus and neonate with encephalopathy. Traumatic brain injury shares many common features with perinatal hypoxic-ischemic encephalopathy. Trauma has a hypoxic component, and one of the 1st physiologic consequences of moderate-severe traumatic brain injury is apnea. Trauma and hypoxia-ischemia initiate an excitotoxic cascade and free radical injury followed by the inflammatory cascade, producing injury in neurons, glial cells and white matter. Increased excitatory amino acids, lipid peroxidation products and alteration in microRNAs and inflammatory markers are common to both traumatic brain injury and perinatal encephalopathy. The blood-brain barrier is disrupted in both leading to egress of substances normally only found in the central nervous system. Brain exosomes may represent ideal biomarker containers, as RNA and protein transported within the vesicles are protected from enzymatic degradation. Evaluation of fetal or neonatal brain derived exosomes that cross the blood-brain barrier and circulate peripherally has been referred to as the liquid brain biopsy. A multiplex of serum biomarkers could improve upon the current imprecise methods of identifying fetal and neonatal brain injury such as fetal heart rate abnormalities, meconium, cord gases at delivery, and Apgar scores. Quantitative biomarker measurements of perinatal brain injury and recovery could lead to operative delivery only in the presence of significant fetal risk, triage to appropriate therapy after birth and measure the effectiveness of treatment.

  17. Biomarker Guided Therapy in Chronic Heart Failure

    Science.gov (United States)

    Bektas, Sema

    2015-01-01

    This review article addresses the question of whether biomarker-guided therapy is ready for clinical implementation in chronic heart failure. The most well-known biomarkers in heart failure are natriuretic peptides, namely B-type natriuretic peptide (BNP) and N-terminal pro-BNP. They are well-established in the diagnostic process of acute heart failure and prediction of disease prognosis. They may also be helpful in screening patients at risk of developing heart failure. Although studied by 11 small- to medium-scale trials resulting in several positive meta-analyses, it is less well-established whether natriuretic peptides are also helpful for guiding chronic heart failure therapy. This uncertainty is expressed by differences in European and American guideline recommendations. In addition to reviewing the evidence surrounding the use of natriuretic peptides to guide chronic heart failure therapy, this article gives an overview of the shortcomings of the trials, how the results may be interpreted and the future directions necessary to fill the current gaps in knowledge. Therapy guidance in chronic heart failure using other biomarkers has not been prospectively tested to date. Emerging biomarkers, such as galectin-3 and soluble ST2, might be useful in this regard, as suggested by several post-hoc analyses. PMID:28785440

  18. Biomarkers of Hypoxic Ischemic Encephalopathy in Newborns

    Directory of Open Access Journals (Sweden)

    Martha V. Douglas-Escobar

    2012-11-01

    Full Text Available As neonatal intensive care has evolved, the focus has shifted from improving mortality alone to an effort to improve both mortality and morbidity. The most frequent source of neonatal brain injury occurs as a result of hypoxic-ischemic injury. Hypoxic-ischemic injury occurs in about 2 of 1,000 full-term infants and severe injured infants will have lifetime disabilities and neurodevelopmental delays. Most recently, remarkable efforts toward neuroprotection have been started with the advent of therapeutic hypothermia and a key step in the evolution of neonatal neuroprotection is the discovery of biomarkers that enable the clinician-scientist to screen infants for brain injury, monitor progression of disease, identify injured brain regions, and assess efficacy of neuroprotective clinical trials. Lastly, biomarkers offer great hope identifying when an injury occurred shedding light on the potential pathophysiology and the most effective therapy. In this article, we will review biomarkers of HIE including S100b, neuron specific enolase, umbilical cord IL-6, CK-BB, GFAP, myelin basic protein, UCHL-1, and pNF-H. We hope to contribute to the awareness, validation and clinical use of established as well as novel neonatal brain injury biomarkers.

  19. Imaging biomarkers in primary brain tumours

    Energy Technology Data Exchange (ETDEWEB)

    Lopci, Egesta; Chiti, Arturo [Humanitas Clinical and Research Center, Nuclear Medicine Department, Rozzano, MI (Italy); Franzese, Ciro; Navarria, Pierina; Scorsetti, Marta [Humanitas Clinical and Research Center, Radiosurgery and Radiotherapy, Rozzano, MI (Italy); Grimaldi, Marco [Humanitas Clinical and Research Center, Radiology, Rozzano, MI (Italy); Zucali, Paolo Andrea; Simonelli, Matteo [Humanitas Clinical and Research Center, Medical Oncology, Rozzano, MI (Italy); Bello, Lorenzo [Humanitas Clinical and Research Center, Neurosurgery, Rozzano, MI (Italy)

    2015-04-01

    We are getting used to referring to instrumentally detectable biological features in medical language as ''imaging biomarkers''. These two terms combined reflect the evolution of medical imaging during recent decades, and conceptually comprise the principle of noninvasive detection of internal processes that can become targets for supplementary therapeutic strategies. These targets in oncology include those biological pathways that are associated with several tumour features including independence from growth and growth-inhibitory signals, avoidance of apoptosis and immune system control, unlimited potential for replication, self-sufficiency in vascular supply and neoangiogenesis, acquired tissue invasiveness and metastatic diffusion. Concerning brain tumours, there have been major improvements in neurosurgical techniques and radiotherapy planning, and developments of novel target drugs, thus increasing the need for reproducible, noninvasive, quantitative imaging biomarkers. However, in this context, conventional radiological criteria may be inappropriate to determine the best therapeutic option and subsequently to assess response to therapy. Integration of molecular imaging for the evaluation of brain tumours has for this reason become necessary, and an important role in this setting is played by imaging biomarkers in PET and MRI. In the current review, we describe most relevant techniques and biomarkers used for imaging primary brain tumours in clinical practice, and discuss potential future developments from the experimental context. (orig.)

  20. Biomarkers and Genetics in Peripheral Artery Disease.

    Science.gov (United States)

    Hazarika, Surovi; Annex, Brian H

    2017-01-01

    Peripheral artery disease (PAD) is highly prevalent and there is considerable diversity in the initial clinical manifestation and disease progression among individuals. Currently, there is no ideal biomarker to screen for PAD, to risk stratify patients with PAD, or to monitor therapeutic response to revascularization procedures. Advances in human genetics have markedly enhanced the ability to develop novel diagnostic and therapeutic approaches across a host of human diseases, but such developments in the field of PAD are lagging. In this article, we will discuss the epidemiology, traditional risk factors for, and clinical presentations of PAD. We will discuss the possible role of genetic factors and gene-environment interactions in the development and/or progression of PAD. We will further explore future avenues through which genetic advances can be used to better our understanding of the pathophysiology of PAD and potentially find newer therapeutic targets. We will discuss the potential role of biomarkers in identifying patients at risk for PAD and for risk stratifying patients with PAD, and novel approaches to identification of reliable biomarkers in PAD. The exponential growth of genetic tools and newer technologies provides opportunities to investigate and identify newer pathways in the development and progression of PAD, and thereby in the identification of newer biomarkers and therapies. © 2016 American Association for Clinical Chemistry.

  1. Phospholipids as Biomarkers for Excessive Alcohol Use

    Science.gov (United States)

    2013-10-01

    NUMBER Phospholipids as Biomarkers for Excessive Alcohol Use 5b. GRANT NUMBER W81XWH-12-1-0497 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...suspected of alcohol abuse. Toxicol Lett, 151(1), 235-241. Graham, D. P., Cardon , A. L., & Uhl, G. R. (2008). An update on substance use and treatment

  2. Blood Biomarkers in Idiopathic Pulmonary Fibrosis.

    Science.gov (United States)

    Guiot, Julien; Moermans, Catherine; Henket, Monique; Corhay, Jean-Louis; Louis, Renaud

    2017-06-01

    Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal lung disease of unknown origin whose incidence has been increasing over the latest decade partly as a consequence of population ageing. New anti-fibrotic therapy including pirfenidone and nintedanib have now proven efficacy in slowing down the disease. Nevertheless, diagnosis and follow-up of IPF remain challenging. This review examines the recent literature on potentially useful blood molecular and cellular biomarkers in IPF. Most of the proposed biomarkers belong to chemokines (IL-8, CCL18), proteases (MMP-1 and MMP-7), and growth factors (IGBPs) families. Circulating T cells and fibrocytes have also gained recent interest in that respect. Up to now, though several interesting candidates are profiling there has not been a single biomarker, which proved to be specific of the disease and predictive of the evolution (decline of pulmonary function test values, risk of acute exacerbation or mortality). Large scale multicentric studies are eagerly needed to confirm the utility of these biomarkers.

  3. Plasma biomarker of dietary phytosterol intake.

    Directory of Open Access Journals (Sweden)

    Xiaobo Lin

    Full Text Available Dietary phytosterols, plant sterols structurally similar to cholesterol, reduce intestinal cholesterol absorption and have many other potentially beneficial biological effects in humans. Due to limited information on phytosterol levels in foods, however, it is difficult to quantify habitual dietary phytosterol intake (DPI. Therefore, we sought to identify a plasma biomarker of DPI.Data were analyzed from two feeding studies with a total of 38 subjects during 94 dietary periods. DPI was carefully controlled at low, intermediate, and high levels. Plasma levels of phytosterols and cholesterol metabolites were assessed at the end of each diet period. Based on simple ordinary least squares regression analysis, the best biomarker for DPI was the ratio of plasma campesterol to the endogenous cholesterol metabolite 5-α-cholestanol (R2 = 0.785, P 0.600; P < 0.01.The ratio of plasma campesterol to the coordinately regulated endogenous cholesterol metabolite 5-α-cholestanol is a biomarker of dietary phytosterol intake. Conversely, plasma phytosterol levels alone are not ideal biomarkers of DPI because they are confounded by large inter-individual variation in absorption and turnover of non-cholesterol sterols. Further work is needed to assess the relation between non-cholesterol sterol metabolism and associated cholesterol transport in the genesis of coronary heart disease.

  4. Functional MRI and CT biomarkers in oncology

    Energy Technology Data Exchange (ETDEWEB)

    Winfield, J.M. [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK Imaging Centre at the Institute of Cancer Research, Sutton (United Kingdom); Institute of Cancer Research and Royal Marsden Hospital, MRI Unit, Sutton (United Kingdom); Payne, G.S.; DeSouza, N.M. [Institute of Cancer Research and Royal Marsden NHS Foundation Trust, CRUK Imaging Centre at the Institute of Cancer Research, Sutton (United Kingdom)

    2015-04-01

    Imaging biomarkers derived from MRI or CT describe functional properties of tumours and normal tissues. They are finding increasing numbers of applications in diagnosis, monitoring of response to treatment and assessment of progression or recurrence. Imaging biomarkers also provide scope for assessment of heterogeneity within and between lesions. A wide variety of functional parameters have been investigated for use as biomarkers in oncology. Some imaging techniques are used routinely in clinical applications while others are currently restricted to clinical trials or preclinical studies. Apparent diffusion coefficient, magnetization transfer ratio and native T{sub 1} relaxation time provide information about structure and organization of tissues. Vascular properties may be described using parameters derived from dynamic contrast-enhanced MRI, dynamic contrast-enhanced CT, transverse relaxation rate (R{sub 2}*), vessel size index and relative blood volume, while magnetic resonance spectroscopy may be used to probe the metabolic profile of tumours. This review describes the mechanisms of contrast underpinning each technique and the technical requirements for robust and reproducible imaging. The current status of each biomarker is described in terms of its validation, qualification and clinical applications, followed by a discussion of the current limitations and future perspectives. (orig.)

  5. Cellular biomarker responses of bagrid catfish, Chrysichthys ...

    African Journals Online (AJOL)

    An assessment of the pollution status of Agboyi creek, a water body associated with various anthropogenic activities was carried out in order to determine responses induced in Catfishes, Chrysichthys nigrodigitatus inhabiting it. Cellular biomarkers of stress including the antioxidative stress enzyme, catalase (CAT), lipid ...

  6. Biomarkers of drug-induced vascular injury

    International Nuclear Information System (INIS)

    Brott, D.; Gould, S.; Jones, H.; Schofield, J.; Prior, H.; Valentin, J.P; Bjurstrom, S.; Kenne, K.; Schuppe-Koistinen, I.; Katein, A.; Foster-Brown, L.; Betton, G.; Richardson, R.; Evans, G.; Louden, C.

    2005-01-01

    In pre-clinical safety studies, drug-induced vascular injury is an issue of concern because there are no obvious diagnostic markers for pre-clinical or clinical monitoring and there is an intellectual gap in our understanding of the pathogenesis of this lesion. While vasodilatation and increased shear stress appear to play a role, the exact mechanism(s) of injury to the primary targets, smooth muscle and endothelial cells are unknown. However, evaluation of novel markers for potential clinical monitoring with a mechanistic underpinning would add value in risk assessment and management. This mini review focuses on the progress to identify diagnostic markers of drug-induced vascular injury. Von Willebrand factor (vWF), released upon perturbation of endothelial cells, is transiently increased in plasma prior to morphological evidence of damage in dogs or rats treated with vascular toxicants. Therefore, vWF might be a predictive biomarker of vascular injury. However, vWF is not an appropriate biomarker of lesion progression or severity since levels return to baseline values when there is morphological evidence of injury. A potential mechanistically linked biomarker of vascular injury is caveolin-1. Expression of this protein, localized primarily to smooth muscle and endothelial cells, decreases with the onset of vascular damage. Since vascular injury involves multiple mediators and cell types, evaluation of a panel rather than a single biomarker may be more useful in monitoring early and severe progressive vascular injury

  7. Pulmonary biomarkers in chronic obstructive pulmonary disease

    NARCIS (Netherlands)

    Barnes, Peter J.; Chowdhury, Badrul; Kharitonov, Sergei A.; Magnussen, Helgo; Page, Clive P.; Postma, Dirkje; Saetta, Marina

    2006-01-01

    There has been increasing interest in using pulmonary biomarkers to understand and monitor the inflammation in the respiratory tract of patients with chronic obstructive pulmonary disease (COPD). In this Pulmonary Perspective we discuss the merits of the various approaches by reviewing the current

  8. Biomarkers and Prognosis in Malignant Lymphomas

    NARCIS (Netherlands)

    Hagenbeek, Anton; Gascoyne, Randy D.; Dreyling, Martin; Kluin, Philip; Engert, Andreas; Salles, Gilles

    2009-01-01

    Approximately 100 hematologists and pathologists from Europe, the United States, and Canada participated in the workshop Biomarkers and Prognosis in Malignant Lymphomas, held in Mandelieu, France,April 11-13, 2008, under the leadership of Anton Hagenbeek, Randy Gascoyne, and Gilles Salles.

  9. Comportamiento de variables clínico-epidemiológicas en pacientes asmáticos. Consultorio Médico de Familia 14, Puerto Padre

    Directory of Open Access Journals (Sweden)

    José Ramón Martínez Pérez

    2015-12-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal en 40 pacientes asmáticos de todas las edades, pertenecientes al Consultorio 14 del área de salud de Puerto Padre, provincia de Las Tunas, durante los meses de enero a junio de 2008; con el objetivo de determinar el comportamiento de variables clínico-epidemiológicas en dichos pacientes. Para cumplimentar los objetivos se diseñó una encuesta que recogió las variables de interés. El análisis se hizo a través del sistema Statistix, permitiendo  obtener  la distribución de frecuencia y los porcientos. El test de Chi-Cuadrado se empleó en la comparación de variables cualitativas. Los resultados fueron descritos, interpretados y comparados con otros estudios. Se concluye que los pacientes grado I según Kraeppelin son los mas representados en nuestra población de pacientes asmáticos;  los broncodilatadores son los medicamentos mas utilizados por la población asmática estudiada; el incumplimiento del tratamiento medicamentoso no se relacionó con la severidad de la enfermedad en la población estudiada;  las malas condiciones de la vivienda y  el tabaquismo influyeron de forma negativa en la evolución del paciente asmático.

  10. Uso de la inmunohistoquímica como herramienta epidemiológica para el diagnóstico de rabia bovina a partir de casos no conclusivos

    Directory of Open Access Journals (Sweden)

    Gloria Jurado G.

    2012-08-01

    Full Text Available Objetivo. Identificar el virus de la rabia en casos de encefalitis bovina a partir de muestras archivadas en el laboratorio sin diagnóstico conclusivo. Materiales y métodos. Doce muestras de cerebro bovino sospechosas de rabia, fueron procesadas por la técnica de inmunoperoxidasa indirecta, usando anticuerpos policlonales contra el agente viral. Resultados. Se demostró la presencia de antígenos virales en tres casos en forma de agregados pequeños en el citoplasma de las neuronas, con un patrón de forma redonda u oval y un número variable de corpúsculos de inclusión viral. Se discute sobre la importancia de los resultados en Colombia, la utilidad de la técnica en las difíciles condiciones de envío de muestras al laboratorio, además la posible relación de los casos negativos con herpesvirus bovino 5. Conclusiones. La utilización de la técnica de inmunohistoquímica para demostrar antígenos del virus rábico en encéfalos bovinos fijados en formol, puede ayudar en el perfeccionamiento del mapa epidemiológico de la enfermedad de la rabia en Colombia y puede disminuir el alto subdiagnóstico de otras enfermedades que afectan el sistema nervioso de los bovinos.

  11. Aspectos entomológicos e epidemiológicos das epidemias de dengue em Fortaleza, Ceará, 2001-2012

    Directory of Open Access Journals (Sweden)

    Rhaquel de Morais Alves Barbosa Oliveira

    2018-02-01

    Full Text Available Resumo Objetivo: descrever os aspectos entomológicos e epidemiológicos das epidemias de dengue ocorridas em Fortaleza, Ceará, Brasil, de 2001 a 2012. Métodos: estudo descritivo com dados dos Sistemas de Informação de Agravos de Notificação (Sinan, de Informações Hospitalares (SIH, do Programa de Febre Amarela e Dengue (2001-2009, do Programa Nacional de Controle da Dengue (2010-2012 e Levantamento Rápido do Índice de Infestação de Aedes aegypti, referentes aos anos quando a incidência da doença superou o percentil 75%. Resultados: De 2001 a 2012 foram notificados 194.446 casos suspeitos de dengue. Os anos epidêmicos foram: 2001, 2006, 2008, 2011 e 2012. Houve aumento progressivo da incidência (587,0/100 mil hab. [2001] e 1.561,1/100 mil hab [2012], com cocirculação de até três sorotipos e elevada infestação vetorial, principalmente em depósitos para armazenar água. Conclusão: após longo período de circulação do vírus em Fortaleza, a dengue permanece como importante problema de saúde, com casos graves e alta letalidade.

  12. Caracterización clínico epidemiológica del bruxismo en pacientes mayores de 15 años

    Directory of Open Access Journals (Sweden)

    Antonio Leyva Ponce de León

    2015-11-01

    Full Text Available Se realizó un estudio descriptivo de corte transversal, con el objetivo de caracterizar clínica y epidemiológicamente el bruxismo en pacientes mayores de 15 años, en el consultorio No. 6, perteneciente al Área de Salud del Policlínico “Romárico Oro Peña”, municipio de Puerto Padre. Se interrogó y se examinó a toda la población incluida en el estudio para determinar las características de esta afección. El grupo más afectado fue el de 25 a 34 años. Se observó un ligero predominio de pacientes del sexo femenino. Referido a la ocupación los más afectados fueron los intelectuales, seguidos de los trabajadores. Según forma de bruxismo y el horario en el que practican este hábito, se aprecia que el rechinamiento estuvo presente en la totalidad de los pacientes, en el horario nocturno, seguido del apretamiento durante el día. En cuanto a los síntomas prevaleció el dolor y cansancio muscular, seguido de los que presentaron fracturas de dientes y restauraciones. El signo más frecuente fue la existencia de patrones no funcionales de desgaste oclusal, seguido de la fractura de dientes y restauraciones.

  13. Tuberculosis en trabajadores de salud: Estudio epidemiológico y clínico en el Hospital Nacional Hipólito Unanue

    Directory of Open Access Journals (Sweden)

    Mayron Nakandakari

    2014-07-01

    Full Text Available Objetivo: Describir las características epidemiológicas y clínicas de los trabajadores de salud del Hospital Nacional Hipólito Unanue (HNHU con diagnóstico de Tuberculosis (TBC entre el 2006 y 2013. Material y métodos: Estudio observacional, descriptivo, longitudinal, retrospectivo, realizado en el HNHU de categoría III-1. La población estudiada estuvo constituida por los trabajadores de salud con diagnóstico de Tuberculosis entre el 2006 y el 2013. La muestra fue todo el universo. La técnica fue de documentación. Se utilizó estadística descriptiva y los programas Microsoft Excel 2010 y SPSS v 19. Resultados: Se identificaron 56 trabajadores de Salud con diagnóstico de TBC, 4 fueron BK (+++ y uno falleció. La frecuencia de los casos tuvo una tendencia a disminuir desde el 2008, con su valor más bajo en el 2012. Conclusiones: La mayoría fueron diagnosticados en el 2007 y 2013, médicos residentes, BK negativo, con TBC pulmonar sensible y del Servicio de Hospitalización de Especialidades

  14. Identificação de casos psiquiátricos em estudos epidemiológicos multifásicos: métodos, problemas e aplicabilidade

    Directory of Open Access Journals (Sweden)

    Andreoli Sérgio B

    2000-01-01

    Full Text Available OBJETIVO: Discutir aspectos metodológicos da estratégia de identificação de casos psiquiátricos, em duas etapas, em estudos epidemiológicos. MÉTODOS: Analisa-se a metodologia utilizada no Estudo Multicêntrico de Morbidade Psiquiátrica do Adulto realizado em três cidades brasileiras, entre 1990-1991. Na primeira etapa do citado estudo, uma amostra aleatória (6.740 indivíduos da população foi selecionada e submetida a um rastreamento com o Questionário de Morbidade Psiquiátrica do Adulto -- QMPA. Na segunda etapa, uma subamostra (775 indivíduos foi selecionada e submetida ao Inventário de Sintomas do DSM-III (Diagnostic and Statistical Manual of Mental Disorders, aplicado por psiquiatras e psicólogos treinados, para confirmação-diagnóstica. RESULTADOS: São descritos os procedimentos empregados para a estimativa das prevalências, mostrando que o fraco desempenho da escala de rastreamento não compromete o método. CONCLUSÃO: A vantagem da metodologia é a de corrigir as distorções apresentadas pelos instrumentos atuais de identificação de casos psiquiátricos.

  15. Raíces históricas, sociales y epidemiológicas de la tuberculosis en Bogotá, Colombia.

    Directory of Open Access Journals (Sweden)

    Alvaro Javier Idrovo

    2004-12-01

    Full Text Available El entendimiento completo de la dinámica epidemiológica actual de la tuberculosis en una sociedad requiere una aproximación holística. En este artículo se resume el comportamiento de la tuberculosis en Bogotá, Colombia, a través del tiempo. En periodos prehispánicos, la frecuencia de la enfermedad fue baja. Durante la Conquista y la Colonia se observó un incremento moderado de la tuberculosis pulmonar y abdominal. Hacia 1870 se inició un acentuado incremento de los casos de tuberculosis pulmonar, asociado con el proceso acelerado de la urbanización de la ciudad. Desde la segunda década del siglo XX, la tuberculosis pulmonar se convirtió en una enfermedad endémica. Después de 1920, la frecuencia fue relativamente estable hasta la década del 70, cuando se presentó un descenso; sin embargo, en los últimos años volvió a aparecer un aumento en el número de casos. La presencia de la tuberculosis en cada periodo se asocia con eventos sociales y ambientales.

  16. Dilema ético y epidemiológico sobre el tratamiento de perros para la leishmaniasis visceral en América Latina

    Directory of Open Access Journals (Sweden)

    Bruno L. Travi

    2014-03-01

    Full Text Available En las Américas hay entre 4.500 y 6.800 casos anuales de leishmaniasis visceral grave y se estima que la mortalidad varía entre 7 y 10 %. Sin embargo, el subregistro y las infecciones subclínicas enmascaran la importancia epidemiológica real de la leishmaniasis visceral. Los esfuerzos de control que típicamente se han enfocado en la aspersión de insecticidas contra los flebotomíneos vectores y el sacrificio de perros, han arrojado resultados dispares. No obstante, miles de perros se sacrifican cada año en países endémicos para leishmaniasis visceral. Además, los lineamientos actuales de los programas de control de la leishmaniasis han prohibido el tratamiento de perros con medicamentos de uso humano, mientras que otras drogas resultan en altas tasas de recaída. La sociedad requiere que los programas de control tengan un manejo más humanitario enfocado a limitar el sacrificio canino. Hay una necesidad urgente de promover la tenencia responsable de los perros y apoyar la investigación en: a terapias veterinarias novedosas, b diagnósticos moleculares de bajo costo y c determinación de los umbrales de capacidad infecciosa canina para el manejo adecuado del reservorio.

  17. O enfermeiro na vigilância epidemiológica no município de Ribeirão Preto 1988-1996 El enfermero en la vigilancia epidemiológica en Ribeirão Preto (1988-1996 Nursing profession in epidemiologic surveillance (ES at Ribeirão Preto (1988-1996

    Directory of Open Access Journals (Sweden)

    Cesar Eduardo Pedersoli

    1998-12-01

    Full Text Available O enfermeiro é inserido nas equipes de Vigilância Epidemiológica (VE da Secretaria Municipal de Saúde de Ribeirão Preto no processo de municipalização da saúde de 1988 a 1996. A abordagem qualitativa é utilizada sendo os dados obtidos através de fontes documentais e bibliográficas e entrevistas semi-estruturadas. O profissional que predomina na equipe da VE é o enfermeiro, fundamentando sua prática na epidemiologia e na gerência, e suas ações se voltam para o controle representado pelas notificações e visitas e para a prevenção, representada pela imunização.El enfermero es considerado en los equipos de vigilancia epidemiológica de la Secretaría Municipal de Salud de Ribeirão Preto en el proceso de municipalización de salud. Con un abordaje cualitativo se obtienen los datos a través de fuentes documentales, bibliográficas y 8 entrevistas semi-estructuradas. El profesional que predomina en el equipo de trabajo es el enfermero, el mismo fundamenta su práctica en la epidemiología y en la gerencia, orientado para el control representado por las notificaciones y visitas y para la prevención representada por la inmunización.The insertion of the nursing profession in Epidemiologic Surveillance (ES at Ribeirão Preto from 1988 to 1996 has been identified in the process of health care decentralization. The qualitative methodology is used based in bibliographic and documentation sources and by 8 semi-structured interviews. Nurses are in greater number than all other health profissionals and their practice are based on the Epidemiology and management of control side, represented by notifications and visits, and the prevention side, represented by immunization.

  18. Phase II cancer clinical trials for biomarker-guided treatments.

    Science.gov (United States)

    Jung, Sin-Ho

    2018-01-01

    The design and analysis of cancer clinical trials with biomarker depend on various factors, such as the phase of trials, the type of biomarker, whether the used biomarker is validated or not, and the study objectives. In this article, we demonstrate the design and analysis of two Phase II cancer clinical trials, one with a predictive biomarker and the other with an imaging prognostic biomarker. Statistical testing methods and their sample size calculation methods are presented for each trial. We assume that the primary endpoint of these trials is a time to event variable, but this concept can be used for any type of endpoint.

  19. Overview of Biomarkers and Surrogate Endpoints in Drug Development

    Directory of Open Access Journals (Sweden)

    John A. Wagner

    2002-01-01

    Full Text Available There are numerous factors that recommend the use of biomarkers in drug development including the ability to provide a rational basis for selection of lead compounds, as an aid in determining or refining mechanism of action or pathophysiology, and the ability to work towards qualification and use of a biomarker as a surrogate endpoint. Examples of biomarkers come from many different means of clinical and laboratory measurement. Total cholesterol is an example of a clinically useful biomarker that was successfully qualified for use as a surrogate endpoint. Biomarkers require validation in most circumstances. Validation of biomarker assays is a necessary component to delivery of high-quality research data necessary for effective use of biomarkers. Qualification is necessary for use of a biomarker as a surrogate endpoint. Putative biomarkers are typically identified because of a relationship to known or hypothetical steps in a pathophysiologic cascade. Biomarker discovery can also be effected by expression profiling experiment using a variety of array technologies and related methods. For example, expression profiling experiments enabled the discovery of adipocyte related complement protein of 30 kD (Acrp30 or adiponectin as a biomarker for in vivo activation of peroxisome proliferator-activated receptors (PPAR γ activity.

  20. More Accurate Oral Cancer Screening with Fewer Salivary Biomarkers

    Directory of Open Access Journals (Sweden)

    James Michael Menke

    2017-10-01

    Full Text Available Signal detection and Bayesian inferential tools were applied to salivary biomarkers to improve screening accuracy and efficiency in detecting oral squamous cell carcinoma (OSCC. Potential cancer biomarkers are identified by significant differences in assay concentrations, receiver operating characteristic areas under the curve (AUCs, sensitivity, and specificity. However, the end goal is to report to individual patients their risk of having disease given positive or negative test results. Likelihood ratios (LRs and Bayes factors (BFs estimate evidential support and compile biomarker information to optimize screening accuracy. In total, 26 of 77 biomarkers were mentioned as having been tested at least twice in 137 studies and published in 16 summary papers through 2014. Studies represented 10 212 OSCC and 25 645 healthy patients. The measure of biomarker and panel information value was number of biomarkers needed to approximate 100% positive predictive value (PPV. As few as 5 biomarkers could achieve nearly 100% PPV for a disease prevalence of 0.2% when biomarkers were ordered from highest to lowest LR. When sequentially interpreting biomarker tests, high specificity was more important than test sensitivity in achieving rapid convergence toward a high PPV. Biomarkers ranked from highest to lowest LR were more informative and easier to interpret than AUC or Youden index. The proposed method should be applied to more recently published biomarker data to test its screening value.

  1. The path from biomarker discovery to regulatory qualification

    CERN Document Server

    Goodsaid, Federico

    2013-01-01

    The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. For complimentary access to chapter 13, 'Classic' Biomarkers of Liver Injury, by John R. Senior, Associate Director for Science, Food and Drug Administration, Silver Spring, Maryland, USA, please visit the following site:  http://tinyurl.com/ClassicBiomarkers Contains a collection of experiences of different...

  2. Biomarkers of intermediate endpoints in environmental and occupational health

    DEFF Research Database (Denmark)

    Knudsen, Lisbeth E; Hansen, Ase M

    2007-01-01

    The use of biomarkers in environmental and occupational health is increasing due to increasing demands on information about health risks from unfavourable exposures. Biomarkers provide information about individual loads. Biomarkers of intermediate endpoints benefit in comparison with biomarkers...... of exposure from the fact that they are closer to the adverse outcome in the pathway from exposure to health effects and may provide powerful information for intervention. Some biomarkers are specific, e.g., DNA and protein adducts, while others are unspecific like the cytogenetic biomarkers of chromosomal...... health effect from the result of the measurement has been performed for the cytogenetic biomarkers showing a predictive value of high levels of CA and increased risk of cancer. The use of CA in future studies is, however, limited by the laborious and sensitive procedure of the test and lack of trained...

  3. Molecular alterations and biomarkers in colorectal cancer

    Science.gov (United States)

    Grady, William M.; Pritchard, Colin C.

    2013-01-01

    The promise of precision medicine is now a clinical reality. Advances in our understanding of the molecular genetics of colorectal cancer genetics is leading to the development of a variety of biomarkers that are being used as early detection markers, prognostic markers, and markers for predicting treatment responses. This is no more evident than in the recent advances in testing colorectal cancers for specific molecular alterations in order to guide treatment with the monoclonal antibody therapies cetuximab and panitumumab, which target the epidermal growth factor receptor (EGFR). In this review, we update a prior review published in 2010 and describe our current understanding of the molecular pathogenesis of colorectal cancer and how these alterations relate to emerging biomarkers for early detection and risk stratification (diagnostic markers), prognosis (prognostic markers), and the prediction of treatment responses (predictive markers). PMID:24178577

  4. Flavonoids as fruit and vegetable intake biomarkers

    DEFF Research Database (Denmark)

    Krogholm, Kirstine Suszkiewicz

    of fruit and vegetable intakes. In Paper I, the urinary recovery of the 7 flavonoids in morning spot urine (i.e. all urine voids from midnight including the first morning void) was also found to respond to moderate increases in the intake of fruits and vegetables. However, the association was somewhat...... weaker than in 24h urine samples, indicating that the 24h urinary recovery of the 7 flavonoids is a stronger biomarker of the intake of fruit and vegetables than the urinary recovery of the 7 flavonoids in morning spot urine. In Paper II, the biokinetic profiles of some of the most important dietary......-individual variation in the absorption and urinary recovery of the flavonoids, and this makes it very difficult to separate individuals according to intake by use of the flavonoid biomarker in urine. The intra-individual variation was on the contrary low, and Paper II therefore supports the assumption, that 24h...

  5. Mass Spectrometry-Based Biomarker Discovery.

    Science.gov (United States)

    Zhou, Weidong; Petricoin, Emanuel F; Longo, Caterina

    2017-01-01

    The discovery of candidate biomarkers within the entire proteome is one of the most important and challenging goals in proteomic research. Mass spectrometry-based proteomics is a modern and promising technology for semiquantitative and qualitative assessment of proteins, enabling protein sequencing and identification with exquisite accuracy and sensitivity. For mass spectrometry analysis, protein extractions from tissues or body fluids and subsequent protein fractionation represent an important and unavoidable step in the workflow for biomarker discovery. Following extraction of proteins, the protein mixture must be digested, reduced, alkylated, and cleaned up prior to mass spectrometry. The aim of our chapter is to provide comprehensible and practical lab procedures for sample digestion, protein fractionation, and subsequent mass spectrometry analysis.

  6. Methylated genes as new cancer biomarkers.

    LENUS (Irish Health Repository)

    Duffy, M J

    2012-02-01

    Aberrant hypermethylation of promoter regions in specific genes is a key event in the formation and progression of cancer. In at least some situations, these aberrant alterations occur early in the formation of malignancy and appear to be tumour specific. Multiple reports have suggested that measurement of the methylation status of the promoter regions of specific genes can aid early detection of cancer, determine prognosis and predict therapy responses. Promising DNA methylation biomarkers include the use of methylated GSTP1 for aiding the early diagnosis of prostate cancer, methylated PITX2 for predicting outcome in lymph node-negative breast cancer patients and methylated MGMT in predicting benefit from alkylating agents in patients with glioblastomas. However, prior to clinical utilisation, these findings require validation in prospective clinical studies. Furthermore, assays for measuring gene methylation need to be standardised, simplified and evaluated in external quality assurance programmes. It is concluded that methylated genes have the potential to provide a new generation of cancer biomarkers.

  7. Models of Hepatocellular Carcinoma and Biomarker Strategy

    Energy Technology Data Exchange (ETDEWEB)

    Bagi, Cedo M., E-mail: cedo.bagi@pfizer.com; Andresen, Catharine J. [Global Science & Technology, PGRD, Pfizer Inc, Groton, CT 06340 (United States)

    2010-07-07

    The overwhelming need to improve preclinical models in oncology has stimulated research efforts to refine and validate robust orthotopic models that closely mimic the disease population and therefore have the potential to better predict clinical outcome with novel therapies. Sophisticated technologies including bioluminescence, contrast enhanced ultrasound imaging, positron emission tomography, computed tomography and magnetic resonance imaging have been added to existing serum- and histology-based biomarkers to assist with patient selection and the design of clinical trials. The rationale for the use of human hepatocellular carcinoma (HCC) cell lines, implementation of xenograft and orthotopic animal models and utilization of available biomarkers have been discussed, providing guidelines to facilitate preclinical research for the development of treatments for HCC patients.

  8. Flavonoids as fruit and vegetable intake biomarkers

    DEFF Research Database (Denmark)

    Krogholm, Kirstine Suszkiewicz

    calculation of the bivariate correlation coefficients is the common approach when using only one reference method. Back in 2002, a strictly controlled dietary intervention study indicated that the sum of 7 different flavonoid aglycones excreted in 24h urine samples potentially could be used as a biomarker...... and cohort studies. The Ph.D. thesis contains four scientific papers. Paper I provides evidence that the sum of 7 flavonoids in 24h urine respond in a linear and sensitive manner to moderate increases in the intake of fruits and vegetables, and thus consolidates that the flavonoids are a valid biomarker...... of fruit and vegetable intakes. In Paper I, the urinary recovery of the 7 flavonoids in morning spot urine (i.e. all urine voids from midnight including the first morning void) was also found to respond to moderate increases in the intake of fruits and vegetables. However, the association was somewhat...

  9. Microparticles as Potential Biomarkers of Cardiovascular Disease

    International Nuclear Information System (INIS)

    França, Carolina Nunes; Izar, Maria Cristina de Oliveira; Amaral, Jônatas Bussador do; Tegani, Daniela Melo; Fonseca, Francisco Antonio Helfenstein

    2015-01-01

    Primary prevention of cardiovascular disease is a choice of great relevance because of its impact on health. Some biomarkers, such as microparticles derived from different cell populations, have been considered useful in the assessment of cardiovascular disease. Microparticles are released by the membrane structures of different cell types upon activation or apoptosis, and are present in the plasma of healthy individuals (in levels considered physiological) and in patients with different pathologies. Many studies have suggested an association between microparticles and different pathological conditions, mainly the relationship with the development of cardiovascular diseases. Moreover, the effects of different lipid-lowering therapies have been described in regard to measurement of microparticles. The studies are still controversial regarding the levels of microparticles that can be considered pathological. In addition, the methodologies used still vary, suggesting the need for standardization of the different protocols applied, aiming at using microparticles as biomarkers in clinical practice

  10. Biomarkers for sepsis: past, present and future

    Directory of Open Access Journals (Sweden)

    Giuseppe Chesi

    2016-12-01

    Full Text Available Sepsis is a complication of severe infection associated with high mortality and open diagnostic issues. Treatment strategies are currently limited and essentially based on prompt recognition, aggressive supportive care and early antibiotic treatment. In the last years, extensive antibiotic use has led to selection, propagation and maintenance of drug-resistant microorganisms. In this context, several biomarkers have been proposed for early identification, etiological definition, risk stratification and improving antibiotic stewardship in septic patient care. Among these molecules, only a few have been translated into clinical practice. In this review, we provided an updated overview of established and developing biomarkers for sepsis, focusing our attention on their pathophysiological profile, advantages, limitations, and appropriate evidence-based use in the management of septic patients.

  11. Biomarkers for Lupus Nephritis: A Critical Appraisal

    Directory of Open Access Journals (Sweden)

    Chi Chiu Mok

    2010-01-01

    Full Text Available Kidney disease is one of the most serious manifestations of systemic lupus erythematosus (SLE. Despite the improvement in the medical care of SLE in the past two decades, the prognosis of lupus nephritis remains unsatisfactory. Besides exploring more effective but less toxic treatment modalities that will further improve the remission rate, early detection and treatment of renal activity may spare patients from intensive immunosuppressive therapies and reduce renal damage. Conventional clinical parameters such as creatinine clearance, proteinuria, urine sediments, anti-dsDNA, and complement levels are not sensitive or specific enough for detecting ongoing disease activity in the lupus kidneys and early relapse of nephritis. Thus, novel biomarkers are necessary to enhance the diagnostic accuracy and sensitivity of lupus renal disease, prognostic stratification, monitoring of treatment response, and detection of early renal flares. This paper reviews promising biomarkers that have recently been evaluated in longitudinal studies of lupus nephritis.

  12. HCC Biomarkers in China and Taiwan

    Directory of Open Access Journals (Sweden)

    Regina M. Santella

    2007-02-01

    Full Text Available

    A number of different types of biomarkers have been used to understand the etiology and progression of hepatocellular cancer (HCC. Perhaps the most well known are the serum/ plasma markers of HBV or HCV infection. These markers include analysis of viral DNA or proteins or antibodies produced against the viral proteins. HBV surface antigen (HBsAg is most frequently used to determine chronic infection with high or low viral replication, while HBeAg is a measure of chronic infection with high viral replication. Analysis of antibodies includes measurement of anti-HBV core antigen, anti-HBV e antigen and anti-HBsAg. The response to immunization can be monitored by analysis of anti-HBsAg. The other major classes of biomarkers used in studies of HCC are biomarkers of exposure to environmental, lifestyle or dietary carcinogens, biomarkers of oxidative stress and early biologic response. In addition, studies of genetic susceptibility have studied polymorphisms in a number of pathways and their role in HCC risk. The biomarkers of exposure include the measurement of carcinogens in urine and carcinogen-DNA and protein adducts. Examples are measurement of aflatoxin and polycyclic aromatic hydrocarbon metabolites, and DNA and protein adducts.

    Biomarkers of oxidative stress include urinary isoprostanes and 8-oxodeoxyguanosine and oxidized plasma proteins. Most of these assays are immunologic although the use of high performance liquid chromatograph (HPLC as well as gas chromatography/mass spectroscopy (GC/MS have been utilized. In nested case-control studies, many of these markers are associated with elevated risk. For example, elevated aflatoxin and polycyclic aromatic hydrocarbon-albumin adducts, aflatoxin metabolites in urine and urinary isoprostanes were observed in baseline samples from

  13. Microparticles as Potential Biomarkers of Cardiovascular Disease

    Energy Technology Data Exchange (ETDEWEB)

    França, Carolina Nunes, E-mail: carolufscar24@gmail.com [Universidade Federal de São Paulo - UNIFESP - UNISA, SP, São Paulo (Brazil); Universidade de Santo Amaro - UNISA, SP, São Paulo (Brazil); Izar, Maria Cristina de Oliveira; Amaral, Jônatas Bussador do; Tegani, Daniela Melo; Fonseca, Francisco Antonio Helfenstein [Universidade Federal de São Paulo - UNIFESP - UNISA, SP, São Paulo (Brazil)

    2015-02-15

    Primary prevention of cardiovascular disease is a choice of great relevance because of its impact on health. Some biomarkers, such as microparticles derived from different cell populations, have been considered useful in the assessment of cardiovascular disease. Microparticles are released by the membrane structures of different cell types upon activation or apoptosis, and are present in the plasma of healthy individuals (in levels considered physiological) and in patients with different pathologies. Many studies have suggested an association between microparticles and different pathological conditions, mainly the relationship with the development of cardiovascular diseases. Moreover, the effects of different lipid-lowering therapies have been described in regard to measurement of microparticles. The studies are still controversial regarding the levels of microparticles that can be considered pathological. In addition, the methodologies used still vary, suggesting the need for standardization of the different protocols applied, aiming at using microparticles as biomarkers in clinical practice.

  14. [Inflammatory biomarkers in ischemic acute coronary syndrome].

    Science.gov (United States)

    Domínguez-Rodríguez, Alberto; Abreu-González, Pedro

    2015-10-01

    Diagnosing acute coronary syndrome (ACS) in the emergency department is often a complex process. Inflammatory markers might be useful for the rapid assessment of a patient's overall risk and might also help predict future episodes. The clinical use of these biomarkers could potentially lower the number of emergency visits and help in the prevention of future adverse events. The aim of this review was to evaluate the clinical utility of markers of cardiovascular inflammation in emergency patients with ACS. Based on a critical analysis of a selection of the literature, we concluded that none of the biomarkers of cardiovascular inflammation would at present be useful for stratifying risk in emergency situations, aiding prognosis, or guiding therapy for patients with ACS.

  15. Identification of Potential Biomarkers for Antimony Susceptibility ...

    Indian Academy of Sciences (India)

    Identification of Potential Biomarkers for Antimony Susceptibility/Resistance in L. donovani Rentala Madhubala School of Life Sciences Jawaharlal Nehru University New Delhi, India · Slide 2 · Slide 3 · Slide 4 · Slide 5 · Slide 6 · Slide 7 · Slide 8 · Slide 9 · Slide 10 · Slide 11 · Slide 12 · Slide 13 · Slide 14 · Slide 15 · Slide 16.

  16. Biomarkers for Wilms Tumor: a Systematic Review

    Science.gov (United States)

    Cone, Eugene B.; Dalton, Stewart S.; Van Noord, Megan; Tracy, Elizabeth T.; Rice, Henry E.; Routh, Jonathan C.

    2016-01-01

    Purpose Wilms tumor is the most common childhood renal malignancy and the fourth most common childhood cancer. Many biomarkers have been studied but there has been no comprehensive summary. We systematically reviewed the literature on biomarkers in Wilms Tumor with the objective of quantifying the prognostic implication of the presence of individual tumor markers. Methods We searched for English language studies from 1980–2015 performed on children with Wilms Tumor under 18 years old with prognostic data. The protocol was conducted as per PRISMA guidelines. Two reviewers abstracted data in duplicate using a standard evaluation form. We performed descriptive statistics, then calculated relative risks and 95% confidence intervals for markers appearing in multiple level 2 or 3 studies. Results 40 studies were included examining 32 biomarkers in 7381 Wilms patients. Studies had a median of 61 patients with 24 biomarker positive patients per study, and a median follow-up of 68.4 months. Median percent of patients in Stage 1, 2, 3, 4, and 5 were 28.5%, 26.4%, 24.5%, 14.1%, and 1.7%, with 10.2% anaplasia. The strongest negative prognostic association was loss of heterozygosity on 11p15, with a risk of recurrence of 5.00, although loss of heterozygosity on 1p and gain of function on 1q were also strongly linked to increased recurrence (2.93 and 2.86 respectively). Conclusions Several tumor markers are associated with an increased risk of recurrence or a decreased risk of overall survival in Wilms Tumor. These data suggest targets for development of diagnostic tests and potential therapies. PMID:27259655

  17. Bayesian methods for proteomic biomarker development

    Directory of Open Access Journals (Sweden)

    Belinda Hernández

    2015-12-01

    In this review we provide an introduction to Bayesian inference and demonstrate some of the advantages of using a Bayesian framework. We summarize how Bayesian methods have been used previously in proteomics and other areas of bioinformatics. Finally, we describe some popular and emerging Bayesian models from the statistical literature and provide a worked tutorial including code snippets to show how these methods may be applied for the evaluation of proteomic biomarkers.

  18. Fibrosis biomarkers in workers exposed to MWCNTs

    International Nuclear Information System (INIS)

    Fatkhutdinova, Liliya M.; Khaliullin, Timur O.; Vasil'yeva, Olga L.; Zalyalov, Ramil R.; Mustafin, Ilshat G.; Kisin, Elena R.; Birch, M. Eileen; Yanamala, Naveena; Shvedova, Anna A.

    2016-01-01

    Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increased in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. - Highlights: • The effects of MWCNT exposure in humans remain unclear. • We found increased KL-6/TGF-β levels in the biofluids of MWCNT-exposed workers.

  19. Biomarkers as Proxies for Life and Environment

    Science.gov (United States)

    Summons, R. E.

    2006-05-01

    Biomarkers are organic molecules that can be used to trace specific types of organisms or biological processes in contemporary ecosystems, ancient sediments and, potentially, beyond the Earth. Biomarkers offer a means to evaluate Earth's biosphere from its earliest development to the modern day. Hydrocarbons, which are the remains of lipids that once resided in the membranes of ancestral organisms, carry chemical and isotopic clues about the nature of early ecosystems. The hydrocarbon remains of fatty acids, sterols, bacterial triterpenoids and pigments are very recalcitrant substances and can be found in rocks as old as 2.8 billion years. These molecules tell us that the three domains, archaea, bacteria and eukarya that comprise all extant life appeared quite early in Earth's history as did the oxygen-producing photosynthesis that oxidized our atmosphere and made it possible for animal life to evolve and increase in complexity. Pigment-derived biomarkers are especially useful for evaluating paleo-environmental conditions. They occur in rocks from the Archean to the present day and can be especially diagnostic for euxinic conditions. The greatest known mass extinction event occurred at the end of the Permian period and extinguished about 70% of the animals and plants that existed at that time. Much controversy surrounds its cause with many different scenarios having been proposed. An international collaboration has enabled biomarker profiles to be obtained from Permian- Triassic boundary sections in China, Australia, Canada, Tibet and Greenland. These data suggest that euxinic conditions prevailed widely in the oceans for an extended period from the Late Permian and that sulfide toxicity may have been a major factor in the demise of both plant and animal life.

  20. Fibrosis biomarkers in workers exposed to MWCNTs

    Energy Technology Data Exchange (ETDEWEB)

    Fatkhutdinova, Liliya M., E-mail: liliya.fatkhutdinova@gmail.com [Kazan State Medical University, ul. Butlerova 49, Kazan 420012 (Russian Federation); Khaliullin, Timur O., E-mail: Khaliullin.40k@gmail.com [Kazan State Medical University, ul. Butlerova 49, Kazan 420012 (Russian Federation); Department of Physiology & Pharmacology, WVU, Morgantown, WV (United States); Vasil' yeva, Olga L., E-mail: volgaleon@gmail.com [Kazan State Medical University, ul. Butlerova 49, Kazan 420012 (Russian Federation); Zalyalov, Ramil R., E-mail: zalyalov.ramil@gmail.com [Kazan State Medical University, ul. Butlerova 49, Kazan 420012 (Russian Federation); Mustafin, Ilshat G., E-mail: ilshat64@mail.ru [Kazan State Medical University, ul. Butlerova 49, Kazan 420012 (Russian Federation); Kisin, Elena R., E-mail: edk8@cdc.gov [National Institute for Occupational Safety and Health, Morgantown, WV (United States); Birch, M. Eileen, E-mail: mib2@cdc.gov [National Institute for Occupational Safety and Health, Cincinnati, OH (United States); Yanamala, Naveena, E-mail: wqu1@cdc.gov [National Institute for Occupational Safety and Health, Morgantown, WV (United States); Shvedova, Anna A., E-mail: ats1@cdc.gov [National Institute for Occupational Safety and Health, Morgantown, WV (United States); Department of Physiology & Pharmacology, WVU, Morgantown, WV (United States)

    2016-05-15

    Multi-walled carbon nanotubes (MWCNT) with their unique physico-chemical properties offer numerous technological advantages and are projected to drive the next generation of manufacturing growth. As MWCNT have already found utility in different industries including construction, engineering, energy production, space exploration and biomedicine, large quantities of MWCNT may reach the environment and inadvertently lead to human exposure. This necessitates the urgent assessment of their potential health effects in humans. The current study was carried out at NanotechCenter Ltd. Enterprise (Tambov, Russia) where large-scale manufacturing of MWCNT along with relatively high occupational exposure levels was reported. The goal of this small cross-sectional study was to evaluate potential biomarkers during occupational exposure to MWCNT. All air samples were collected at the workplaces from both specific areas and personal breathing zones using filter-based devices to quantitate elemental carbon and perform particle analysis by TEM. Biological fluids of nasal lavage, induced sputum and blood serum were obtained from MWCNT-exposed and non-exposed workers for assessment of inflammatory and fibrotic markers. It was found that exposure to MWCNTs caused significant increase in IL-1β, IL6, TNF-α, inflammatory cytokines and KL-6, a serological biomarker for interstitial lung disease in collected sputum samples. Moreover, the level of TGF-β1 was increased in serum obtained from young exposed workers. Overall, the results from this study revealed accumulation of inflammatory and fibrotic biomarkers in biofluids of workers manufacturing MWCNTs. Therefore, the biomarkers analyzed should be considered for the assessment of health effects of occupational exposure to MWCNT in cross-sectional epidemiological studies. - Highlights: • The effects of MWCNT exposure in humans remain unclear. • We found increased KL-6/TGF-β levels in the biofluids of MWCNT-exposed workers.

  1. Measurement of Soluble Biomarkers by Flow Cytometry

    OpenAIRE

    Antal-Szalm?s, P?ter; Nagy, B?la; Debreceni, Ildik? Beke; Kappelmayer, J?nos

    2013-01-01

    Microparticle based flow cytometric assays for determination of the level of soluble biomarkers are widely used in several research applications and in some diagnostic setups. The major advantages of these multiplex systems are that they can measure a large number of analytes (up to 500) at the same time reducing assay time, costs and sample volume. Most of these assays are based on antigen-antibody interactions and work as traditional immunoassays, but nucleic acid alterations ? by using spe...

  2. New serum biomarkers for prostate cancer diagnosis

    Science.gov (United States)

    Chadha, Kailash C.; Miller, Austin; Nair, Bindukumar B.; Schwartz, Stanley A.; Trump, Donald L.; Underwood, Willie

    2014-01-01

    Background Prostate-specific antigen (PSA) is currently used as a biomarker for diagnosis and management of prostate cancer (CaP). However, PSA typically lacks the sensitivity and specificity desired of a diagnostic marker. Objective The goal of this study was to identify an additional biomarker or a panel of biomarkers that is more sensitive and specific than PSA in differentiating benign versus malignant prostate disease and/or localized CaP versus metastatic CaP. Methods Concurrent measurements of circulating interleukin-8 (IL-8), Tumor necrosis factor-α (TNF-α) and soluble tumor necrosis factor-α receptors 1 (sTNFR1) were obtained from four groups of men: (1) Controls (2) with elevated prostate-specific antigen with a negative prostate biopsy (elPSA_negBx) (3) with clinically localized CaP and (4) with castration resistant prostate cancer. Results TNF-α Area under the receiver operating characteristic curve (AUC = 0.93) and sTNFR1 (AUC = 0.97) were strong predictors of elPSA_negBx (vs. CaP). The best predictor of elPSA_negBx vs CaP was sTNFR1 and IL-8 combined (AUC = 0.997). The strongest single predictors of localized versus metastatic CaP were TNF-α (AUC = 0.992) and PSA (AUC = 0.963) levels. Conclusions The specificity and sensitivity of a PSA-based CaP diagnosis can be significantly enhanced by concurrent serum measurements of IL-8, TNF-α and sTNFR1. In view of the concerns about the ability of PSA to distinguish clinically relevant CaP from indolent disease, assessment of these biomarkers in the larger cohort is warranted. PMID:25593898

  3. Recent developments in biomarkers in Parkinson disease

    Science.gov (United States)

    Schapira, Anthony H.V.

    2013-01-01

    Purpose of review Parkinson disease is the second most common neurodegenerative disease after Alzheimer disease, and current demographic trends indicate a life-time risk approaching 4% and predict a doubling of prevalence by 2030. Strategies are being developed to apply recent advances in our understanding of the cause of Parkinson disease to the development of biomarkers that will enable the identification of at-risk individuals, enable early diagnosis and reflect the progression of disease. The latter will be particularly important for the testing of disease-modifying therapies. This review summarizes recent advances in Parkinson disease biomarker development. Recent findings Recent reports continue to reflect the application of a variety of clinical, imaging or biochemical measurements, alone or in combination, to general Parkinson disease populations. Probably the most promising is the assay of alpha-synuclein in the diagnosis and evolution of Parkinson disease. At present, detection techniques are still being refined, but once accurate and reproducible assays are available, it will be important to define the relationship of these to early diagnosis and progression. Alpha-synuclein concentrations may also be modulated by certain disease-modifying agents in development and so may represent a measure of their efficacy. It has to be accepted that no single measure currently fulfils all the necessary criteria for a biomarker in Parkinson disease, but combinations of measures are more likely to deliver benefit. Summary The Parkinson disease biomarker field is approaching a stage when certain combinations of clinical, imaging and biochemical measures may identify a proportion of individuals at risk for developing the disease. However, their general applicability may be limited. Attention is now turning to stratification of Parkinson disease into certain at-risk groups defined by genotype. The application of multimodal screening to these populations may be more

  4. Aspectos epidemiológicos da infecção por Haemophilus influenzae tipo b Epidemiologic aspects of Haemophilus influenzae type b infection

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    Maria Angela Loguercio Bouskela

    2000-05-01

    Full Text Available O objetivo do presente trabalho foi revisar o papel do Haemophilus influenzae tipo b (Hib como um dos patógenos mais importantes implicados em doenças infecciosas invasivas, especialmente nos 2 primeiros anos de vida. Nos países em desenvolvimento, o H. Influenzae chega a causar 30% dos casos de pneumonia com cultura positiva e de 20 a 60% dos casos de meningite bacteriana. No presente estudo, dados epidemiológicos do Brasil foram comparados com dados internacionais obtidos em bancos de dados (Medline, 1966 a 1995; LILACS, 1982 a 1995; Thesis databank, 1980 a 1995; e Dissertation abstracts, 1988 a 1994. Analisámos o coeficiente de incidência do Hib no Brasil por estado e por faixa etária, com estratificação inclusive para o 1° ano de vida. A meningite foi utilizada como marcador do coeficiente de incidência devido às dificuldades para obter material adequado para a identificação do microrganismo nos outros quadros, como pneumonia, osteomielite, epiglotite ou endocardite. Nossa análise revelou que os dados nacionais mascaram a incidência e a letalidade regionais do H. influenzae: por exemplo, em 1991, a incidência no Brasil foi de 18,4 em 100 000 crianças menores de 1 ano; no mesmo período, a incidência no Distrito Federal foi de 175 em 100 000 crianças entre 4 e 6 meses. Além disso, a letalidade na região Norte foi de 35% em 1987, contra 22% para o Brasil como um todo. Nosso estudo abre a discussão sobre aspectos epidemiológicos relevantes das infecções por Hib e sobre o custo-benefício da profilaxia e vacinação nas faixas etárias de maior risco.This paper reviews the role of Haemophilus influenzae type b (Hib as one of the most important pathogens causing invasive infectious diseases, especially in the first 2 years of life. In developing countries H. influenzae is responsible for 30% of all pneumonia cases with positive cultures and for 20% to 60% of all bacterial meningitis cases. In this study we compared

  5. Fungemia in a university hospital: an epidemiological approach Fungemia em hospital universitário: uma abordagem epidemiológica

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    Fabíola Maria Marques do Couto

    2011-12-01

    -se muitas vezes fatal. O crescente número de casos de fungemia associados ao mau prognóstico resultou na realização desta pesquisa que teve por objetivo diagnosticar e avaliar aspectos epidemiológicos das infecções hematogênicas por fungos. MÉTODOS: O estudo incluiu 58 amostras de sangue coletadas, durante um ano, de pacientes internados no Hospital das Clínicas da Universidade Federal de Pernambuco, através da punção venosa em tubos a vácuo. As amostras de sangue foram processadas para exame direto e cultura e a identificação, conduzida através da observação das características macroscópicas, microscópicas e quando necessárias fisiológicas. RESULTADOS: Oito (13,8% episódios de fungemia foram identificados, correspondendo ao total das amostras e os agentes etiológicos envolvidos foram Candida, Histoplasma, Trichosporon, Cryptococcus e um fungo demáceo. C. albicans foi a espécie prevalente com 37,5% dos casos. A maior parte dos pacientes acometidos pertencia ao sexo masculino, na idade adulta. Não houve predominância para nenhuma atividade de risco e a síndrome da imunodeficiência adquirida foi a patologia de base mais citada. CONCLUSÕES: O isolamento de fungos considerados emergentes como C. membranifaciens e espécies demáceas ressaltam a importância do acompanhamento epidemiológico dos casos de fungemia em imunocomprometidos, uma vez que a escolha terapêutica depende do conhecimento do agente etiológico.

  6. Padrão facial na dentadura decídua: estudo epidemiológico Facial pattern in the deciduous dentition: epidemiologic study

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    Omar Gabriel da Silva Filho

    2008-08-01

    Full Text Available INTRODUÇÃO: é possível definir a morfologia facial e o padrão de crescimento em idade precoce, a partir da dentadura decídua completa. OBJETIVOS: frente à escassez de trabalhos na literatura pertinente ao assunto, a presente pesquisa explora o diagnóstico epidemiológico da face no estágio de dentadura decídua. METODOLOGIA: a amostra foi composta por 2.009 crianças de etnia brasileira, de ambos os gêneros, entre 3 e 6 anos de idade, no período de dentadura decídua completa, de 20 pré-escolas do município de Bauru/SP. RESULTADOS E CONCLUSÕES: baseando-se nos resultados obtidos no levantamento epidemiológico, foi encontrado - na análise em norma lateral - predomínio de crianças Padrão I (63,22% em relação ao Padrão II (33,10% e Padrão III (3,68%, não havendo diferenças estatisticamente significativas quanto ao gênero. Na análise em norma frontal, houve predomínio do tipo mesofacial (64,56% em relação ao dolicofacial (21,90% e braquifacial (13,54%, sendo que a proporção do tipo braquifacial nas meninas foi significativamente superior em relação aos meninos. Na distribuição dos tipos faciais frontais dentro dos padrões faciais sagitais ficou evidenciada uma manifestação mais freqüente do tipo dolicofacial dentro dos Padrões II e III, sendo encontrado dimorfismo quanto ao gênero, notadamente no Padrão I, onde houve maior manifestação do tipo braquifacial e menor manifestação do dolicofacial no gênero feminino.INTRODUCTION: It is possible to define the facial morphology and growth pattern in early ages, starting from mature deciduous dentition. AIM: Due to the lack of studies about this issue in the deciduous dentition, the current paper aims to present the epidemiologic diagnosis of the face in this stage of the occlusal development. METHODS: The sample was comprised of 2,009 Brazilian children aged between 3 and 6 years, all in the deciduous dentition, from 20 schools in Bauru/SP. RESULTS AND

  7. Situação epidemiológica da brucelose bovina no Estado de Sergipe Epidemiological situation of bovine brucellosis in the State of Sergipe, Brazil

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    V.G.S.O. Silva

    2009-11-01

    Full Text Available Realizou-se um estudo para caracterizar a situação epidemiológica da brucelose bovina no Estado de Sergipe. O Estado foi estratificado em dois circuitos produtores. Em cada circuito produtor foram amostradas aleatoriamente cerca de 300 propriedades e, dentro dessas foi escolhido de forma aleatória um número pré-estabelecido de animais, dos quais foi obtida uma amostra de sangue. No total foram amostrados 4.757 animais, provenientes de 590 propriedades. Em cada propriedade amostrada foi aplicado um questionário epidemiológico para verificar o tipo de exploração da propriedade e as práticas zootécnicas e sanitárias que poderiam estar associadas ao risco de infecção pela doença. O protocolo de testes utilizado foi o da triagem com o teste do antígeno acidificado tamponado e a confirmação dos positivos com o teste do 2-mercaptoetanol. O rebanho foi considerado positivo, se pelo menos um animal foi reagente às duas provas sorológicas. A prevalência de focos e a de animais foram: 12,6% [9,2-16,0%] e 3,4% [2,3-4,4%], respectivamente. As prevalências de focos e de animais infectados para os circuitos pecuários foram: circuito 1, 11,1% [7,9-15,0%] e 2,6% [1,6-3,5%]; circuito 2, 12,9% [9,1-17,6%] e 6,2% [3,0-9,5%]. Os fatores de risco (odds ratio, OR associados à condição de foco foram: assistência veterinária (OR= 2,89 [1,15-7,23], tamanho do rebanho ≥30 fêmeas adultas (OR= 1,88 [1,07-3,28] e uso de inseminação artificial (OR= 1,92 [0,84-4,38].A study to characterize the epidemiological situation of bovine brucellosis in the State of Sergipe was carried out. The State was divided in two regions. Around three hundred herds were randomly sampled in each region and a pre-established number of animals were sampled in each of these herds. A total of 4,757 serum samples from 590 herds were collected. In each herd, it was applied an epidemiological questionnaire focused on herd traits as well as husbandry and sanitary practices

  8. Salivary pH: A diagnostic biomarker

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    Sharmila Baliga

    2013-01-01

    Full Text Available Objectives: Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. Study Design: The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. Results: The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001 whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001. Conclusion: These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.

  9. Salivary pH: A diagnostic biomarker.

    Science.gov (United States)

    Baliga, Sharmila; Muglikar, Sangeeta; Kale, Rahul

    2013-07-01

    Saliva contains a variety of host defense factors. It influences calculus formation and periodontal disease. Different studies have been done to find exact correlation of salivary biomarkers with periodontal disease. With a multitude of biomarkers and complexities in their determination, the salivary pH may be tried to be used as a quick chairside test. The aim of this study was to analyze the pH of saliva and determine its relevance to the severity of periodontal disease. The study population consisted of 300 patients. They were divided into three groups of 100 patients each: Group A had clinically healthy gingiva, Group B who had generalized chronic gingivitis and Group C who had generalized chronic periodontitis. The randomized unstimulated saliva from each patient was collected and pH was tested. Data was analyzed statistically using analysis of variance technique. The salivary pH was more alkaline for patients with generalized chronic gingivitis as compared with the control group (P = 0.001) whereas patients with generalized chronic periodontitis had more acidic pH as compared with the control group (P = 0.001). These results indicate a significant change in the pH depending on the severity of the periodontal condition. The salivary pH shows significant changes and thus relevance to the severity of periodontal disease. Salivary pH may thus be used as a quick chairside diagnostic biomarker.

  10. Plasma biomarker of dietary phytosterol intake.

    Science.gov (United States)

    Lin, Xiaobo; Racette, Susan B; Ma, Lina; Wallendorf, Michael; Spearie, Catherine Anderson; Ostlund, Richard E

    2015-01-01

    Dietary phytosterols, plant sterols structurally similar to cholesterol, reduce intestinal cholesterol absorption and have many other potentially beneficial biological effects in humans. Due to limited information on phytosterol levels in foods, however, it is difficult to quantify habitual dietary phytosterol intake (DPI). Therefore, we sought to identify a plasma biomarker of DPI. Data were analyzed from two feeding studies with a total of 38 subjects during 94 dietary periods. DPI was carefully controlled at low, intermediate, and high levels. Plasma levels of phytosterols and cholesterol metabolites were assessed at the end of each diet period. Based on simple ordinary least squares regression analysis, the best biomarker for DPI was the ratio of plasma campesterol to the endogenous cholesterol metabolite 5-α-cholestanol (R2 = 0.785, P 0.600; P phytosterol intake. Conversely, plasma phytosterol levels alone are not ideal biomarkers of DPI because they are confounded by large inter-individual variation in absorption and turnover of non-cholesterol sterols. Further work is needed to assess the relation between non-cholesterol sterol metabolism and associated cholesterol transport in the genesis of coronary heart disease.

  11. Biomarkers and correlative endpoints for immunotherapy trials.

    Science.gov (United States)

    Morse, Michael A; Osada, Takuya; Hobeika, Amy; Patel, Sandip; Lyerly, H Kim

    2013-01-01

    Immunotherapies for lung cancer are reaching phase III clinical trial, but the ultimate success likely will depend on developing biomarkers to guide development and choosing patient populations most likely to benefit. Because the immune response to cancer involves multiple cell types and cytokines, some spatially and temporally separated, it is likely that multiple biomarkers will be required to fully characterize efficacy of the vaccine and predict eventual benefit. Peripheral blood markers of response, such as the ELISPOT assay and cytokine flow cytometry analyses of peripheral blood mononuclear cells following immunotherapy, remain the standard approach, but it is increasingly important to obtain tissue to study the immune response at the site of the tumor. Earlier clinical endpoints such as response rate and progression-free survival do not correlate with overall survival demonstrated for some immunotherapies, suggesting the need to develop other intermediary clinical endpoints. Insofar as all these biomarkers and surrogate endpoints are relevant in multiple malignancies, it may be possible to extrapolate findings to immunotherapy of lung cancer.

  12. Biomarkers for cardiac cachexia: reality or utopia.

    Science.gov (United States)

    Martins, Telma; Vitorino, Rui; Amado, Francisco; Duarte, José Alberto; Ferreira, Rita

    2014-09-25

    Cardiac cachexia is a serious complication of chronic heart failure, characterized by significant weight loss and body wasting. Chronic heart failure-related muscle wasting results from a chronic imbalance in the activation of anabolic or catabolic pathways, caused by a series of immunological, metabolic, and neurohormonal processes. In spite of the high morbidity and mortality associated to this condition, there is no universally accepted definition or specific biomarkers for cardiac cachexia, which makes its diagnosis and treatment difficult. Several hormonal, inflammatory and oxidative stress molecules have been proposed as serological markers of prognosis in cardiac cachexia but with doubtful success. As individual biomarkers may have limited sensitivity and specificity, multimarker strategies involving mediators of the biological processes modulated by cardiac cachexia will strongly contribute for the diagnosis and management of the disease, as well as for the establishment of new therapeutic targets. An integrated analysis of the biomarkers proposed so far for cardiac cachexia is made in the present review, highlighting the biological processes to which they are related. Copyright © 2014 Elsevier B.V. All rights reserved.

  13. Curated compendium of human transcriptional biomarker data.

    Science.gov (United States)

    Golightly, Nathan P; Bell, Avery; Bischoff, Anna I; Hollingsworth, Parker D; Piccolo, Stephen R

    2018-04-17

    One important use of genome-wide transcriptional profiles is to identify relationships between transcription levels and patient outcomes. These translational insights can guide the development of biomarkers for clinical application. Data from thousands of translational-biomarker studies have been deposited in public repositories, enabling reuse. However, data-reuse efforts require considerable time and expertise because transcriptional data are generated using heterogeneous profiling technologies, preprocessed using diverse normalization procedures, and annotated in non-standard ways. To address this problem, we curated 45 publicly available, translational-biomarker datasets from a variety of human diseases. To increase the data's utility, we reprocessed the raw expression data using a uniform computational pipeline, addressed quality-control problems, mapped the clinical annotations to a controlled vocabulary, and prepared consistently structured, analysis-ready data files. These data, along with scripts we used to prepare the data, are available in a public repository. We believe these data will be particularly useful to researchers seeking to perform benchmarking studies-for example, to compare and optimize machine-learning algorithms' ability to predict biomedical outcomes.

  14. Urine Exosomes: An Emerging Trove of Biomarkers.

    Science.gov (United States)

    Street, J M; Koritzinsky, E H; Glispie, D M; Star, R A; Yuen, P S T

    Exosomes are released by most cells and can be isolated from all biofluids including urine. Exosomes are small vesicles formed as part of the endosomal pathway that contain cellular material surrounded by a lipid bilayer that can be traced to the plasma membrane. Exosomes are potentially a more targeted source of material for biomarker discovery than unfractionated urine, and provide diagnostic and pathophysiological information without an invasive tissue biopsy. Cytoplasmic contents including protein, mRNA, miRNA, and lipids have all been studied within the exosomal fraction. Many prospective urinary exosomal biomarkers have been successfully identified for a variety of kidney or genitourinary tract conditions; detection of systemic conditions may also be possible. Isolation and analysis of exosomes can be achieved by several approaches, although many require specialized equipment or involve lengthy protocols. The need for timely analysis in the clinical setting has driven considerable innovation with several promising options recently emerging. Consensus on exosome isolation, characterization, and normalization procedures would resolve critical clinical translational bottlenecks for existing candidate exosomal biomarkers and provide a template for additional discovery studies. 2017 Published by Elsevier Inc.

  15. Individual Biomarkers Using Molecular Personalized Medicine Approaches.

    Science.gov (United States)

    Zenner, Hans P

    2017-01-01

    Molecular personalized medicine tries to generate individual predictive biomarkers to assist doctors in their decision making. These are thought to improve the efficacy and lower the toxicity of a treatment. The molecular basis of the desired high-precision prediction is modern "omex" technologies providing high-throughput bioanalytical methods. These include genomics and epigenomics, transcriptomics, proteomics, metabolomics, microbiomics, imaging, and functional analyses. In most cases, producing big data also requires a complex biomathematical analysis. Using molecular personalized medicine, the conventional physician's check of biomarker results may no longer be sufficient. By contrast, the physician may need to cooperate with the biomathematician to achieve the desired prediction on the basis of the analysis of individual big data typically produced by omex technologies. Identification of individual biomarkers using molecular personalized medicine approaches is thought to allow a decision-making for the precise use of a targeted therapy, selecting the successful therapeutic tool from a panel of preexisting drugs or medical products. This should avoid the treatment of nonresponders and responders that produces intolerable unwanted effects. © 2017 S. Karger AG, Basel.

  16. Características epidemiológicas de la cirrosis hepática en el Hospital Civil de Guadalajara

    Directory of Open Access Journals (Sweden)

    CAMPOLLO OCTAVIO

    1997-01-01

    Full Text Available Objetivo. Estudiar prospectivamente las características demográficas y epidemiológicas de los pacientes con cirrosis hepática en el Hospital Civil de Guadalajara en un periodo de un año. Material y métodos. Se estudiaron 157 pacientes (48 mujeres y 109 hombres, de los servicios de Medicina Interna, Gastroenterología y Clínica de Hígado con diagnóstico de cirrosis hepática el cual se hizo con base en la información clínica, bioquímica o histopatológica; asimismo, se les aplicó un cuestionario especializado en enfermedades hepáticas. Resultados. La principal causa de la cirrosis fue el alcoholismo (38% en mujeres y 95% en hombres, seguida de la etiología viral. Las bebidas más frecuentes fueron el tequila y el alcohol de 96° G.L. El grado de insuficiencia hepática más frecuentemente observado fue el de Child-Pugh "B" en mujeres y "C" en los hombres. Las complicaciones más frecuentes fueron hemorragia de tubo digestivo, ascitis y encefalopatía hepática. Se observaron diferencias en varias características relacionadas con el sexo de los pacientes. Conclusiones. El alcoholismo fue la primera causa de cirrosis hepática. En mujeres la segunda causa fue la viral (16.7%. Se propone un comité nacional de vigilancia de enfermedades del hígado, para generar una información más completa y detallada acerca de la epidemiología de la cirrosis hepática.

  17. Situación epidemiológica y de los factores de riesgo de transmisión de Leishmania infantum en España

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    Berta Suárez Rodríguez

    2012-01-01

    Full Text Available En España la leishmaniasis es una zoonosis endémica presente en la mayor parte del territorio peninsular e Islas Baleares. El parásito que se detecta es la Leishmania infantum y el principal reservorio es el perro. Los vectores competentes para transmitir el parásito son los flebotomos, de los que existen dos especies distribuidas por todo el territorio peninsular e Islas Baleares. En este artículo se revisa la situación actual y el comportamiento de la leishmaniasis en España. Se analiza y compara la información sobre la enfermedad procedente de las altas hospitalarias y de la Red Nacional de Vigilancia Epidemiológica así como los factores de riesgo identificados en estudios anteriores que facilitan la transmisión. Desde 2009 está teniendo lugar un brote en el suroeste de la Comunidad de Madrid, destacando el elevado número de casos, cerca de 400 y la detección de un nuevo reservorio, la liebre. Las condiciones que pueden incrementar la incidencia de la leishmaniasis están asociadas al aumento del número de vectores infectados, al de la densidad del flebotomo, al de hospedadores o la aparición de nuevos reservorios en un área geográfica. Esta infección tiene una dinámica de transmisión compleja y para responder oportunamente a los brotes debe estar previamente desarrollado un plan de acción integral y multisectorial en el que participen todas las instituciones involucradas. Ante un brote, es importante estudiar los factores que condicionan la transmisión del lugar y adaptar el plan de acción a sus características específicas.

  18. Comportamiento clínico-epidemiológico de la Enteropatía parasitaria en el municipio Las Tunas durante el año 2011

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    Arley Fajardo Ochoa

    2015-11-01

    Full Text Available Dada la alta incidencia de pacientes con enteropatía ambiental y la carencia de estudios que la caractericen, se realizó un estudio descriptivo de corte transversal  en 87 niños, con diagnóstico de la misma, atendidos en el Hospital Pediátrico Docente “Mártires de Las Tunas” en el año 2011, con el objetivo de caracterizarlos desde el punto de vista clínico y epidemiológico. Los datos se obtuvieron del propio paciente a través  de  un interrogatorio y examen físico exhaustivo. Para el procesamiento de los datos se utilizó la estadística descriptiva a través del análisis porcentual. Los principales resultados estuvieron dados por un predominio del grupo de edad de 0 a 9 años, del sexo masculino. Los síntomas y signos principales fueron las diarreas crónicas y la distensión abdominal; los principales parásitos encontrados fueron la Giardia y el Áscaris lumbricoides. En más de la mitad de los pacientes prevalecieron los hábitos higiénicos y el estado nutricional deficientes, la ingestión de agua sin hervir y  la evacuación de excretas en formas no sanitarias.  Se recomienda realizar un estudio analítico de tipo caso control, para determinar la asociación de estas variables con la enteropatía parasitaria en la población estudiada.

  19. Brazil is getting older: demographic changes and epidemiological challenges Envelhecimento populacional do Brasil: mudanças demográficas e desafios epidemiológicos

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    Renato P. Veras

    1991-12-01

    Full Text Available Population ageing is currently a phenomenon not only in developed countries but also in third world countries. In this paper the features of a population's ageing and the process of epidemiological transition are discussed along with the worldwide changes in age-structure. Population statistics in Brazil and the characteristics of the elderly population are presented and analysed in the light of recent changes. The Brazilian elderly population is also discussed, particularly the issues relating to the social cost of the aged population, its urban and rural distribution, the elderly by sex, marital status and level of schooling, and emphasis is given to the imbalance of the sexes and the consequences of it for women.O crescimento da população idosa é um fenômeno que ocorre nos países centrais, mas também, de modo crescente, nos países do Terceiro Mundo. Este artigo apresenta os motivos deste crescimento, discute o processo de transição epidemiológica, as mudanças na estrutura etária da população idosa em todo o mundo, e em particular no Brasil. Estatísticas da população brasileira e as características do idoso brasileiro são apresentadas e analisadas em função das mudanças ocorridas recentemente. O artigo aborda vários tópicos relacionados com o idoso brasileiro: o custo financeiro para a sociedade manter uma população idosa, a distribuição urbana e rural, a diferença numérica entre sexos, o estado conjugal, a escolaridade, entre outros. Ênfase é conferida a algumas características e particularidades da mulher idosa.

  20. Perfil epidemiológico de pacientes na fila de transplante de córnea no estado de Pernambuco - Brasil

    Directory of Open Access Journals (Sweden)

    Hirlana Gomes Almeida

    2014-01-01

    Full Text Available Objetivo: Descrever o perfil epidemiológico de pacientes na fila de transplante de córnea no estado de Pernambuco, Brasil. Métodos: Estudo transversal e retrospectivo realizado no período 01/06/2011 a 31/05/2012, com 871 pacientes cadastrados na fila de espera para transplante de córnea na Central de Notificação, Captação e Distribuição de Órgãos de Pernambuco (CNCDO/PE. Os dados foram coletados por meio de protocolos baseados nas fichas de cadastro de receptor de córnea. Resultados: Em relação à frequência, obteve-se 54% do gênero feminino, 35% na faixa etária de 61 a 80 anos; 60% transplantados; 52% provenientes da região Metropolitana do Recife; 57% que aguardaram 1 a 6 meses o transplante; 82% com indicação de transplante óptico; 5% com prioridade na fila de espera (destes 48% por perfuração ocular e 37% cujo centro transplantador era a Fundação Altino Ventura (FAV. As principais indicações para transplante de córnea foram leucoma (33%, ceratocone (22% e ceratopatia bolhosa (18%. Conclusão: Verificou-se que a maioria dos pacientes encontra-se na faixa etária de 61 a 80 anos; era da Mesorregião Metropolitana de Recife; foi submetida ao transplante de córnea; aguardou de um a seis meses para realizar o transplante; teve como diagnóstico o leucoma, seguido por ceratocone e ceratopatia bolhosa; teve como indicação o transplante óptico e teve como centro transplantador a FAV.

  1. Aspectos epidemiológicos da leishmaniose tegumentar em área endêmica do Estado do Paraná, Brasil

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    Thaís Gomes Verzignassi Silveira

    Full Text Available Realizou-se em 1992 e 1993 um inquérito epidemiológico para leishmaniose tegumentar (LT envolvendo 684 indivíduos de uma população de aproximadamente 1400 pessoas de seis localidades agrícolas (Fazenda Palmital, Cerâmica Andirá, Fazenda Jussara, Fazenda Lagoa, Destilaria Melhoramentos e Fazenda Mururê de uma área endêmica nos Municípios de Jussara e Terra Boa, no Norte do Estado do Paraná, Brasil. Do total de 684 indivíduos estudados, 19,9% tinham história de LT. Ressalta-se que na Fazenda Jussara ocorreu o maior percentual de pessoas com história de LT (51/126 ou 40,5%. Das 684 reações de imunofluorescência indireta realizadas, 58 (8,5% tiveram títulos significativos, e destas, 17 (29,3% eram de pessoas sem história de LT. A intradermorreação de Montenegro foi realizada em 97 indivíduos com história de LT, sendo positiva em 80 (82,5% deles. No momento do inquérito, sete indivíduos apresentavam lesão característica de LT, e em quatro deles a pesquisa de Leishmania sp. foi positiva. A cepa de Leishmania isolada de um destes indivíduos foi identificada como Leishmania (Viannia braziliensis.

  2. Perfil clínico e epidemiológico de pacientes em reação hansênica

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    Tatiane Aparecida Queiroz

    Full Text Available RESUMO Objetivo Identificar o perfil clínico e epidemiológico de pacientes em tratamento para reações hansênicas. Método Estudo quantitativo, descritivo, transversal, realizado entre outubro de 2013 e abril de 2014, com 61 usuários, em um centro de referência de um estado nordestino. Os testes estatísticos utilizados consideraram um nível de significância de 0,05. Resultados Predominou o sexo masculino (57,38%, com baixa renda familiar (50,82% e ensino fundamental incompleto (75,41%. No diagnóstico, 52,45% já apresentava algum grau de incapacidade física. Houve associações entre a forma clínica e o momento de manifestação das reações (p= 0,034. A análise de resíduos apontou que a forma neural pura associa-se às reações antes do tratamento e a dimorfa associa-se às reações durante o tratamento. Conclusão A divulgação do quadro clínico da forma neural pura e a detecção precoce dos casos contribuiriam fortemente para a promoção da saúde da população, possibilitando o cumprimento do objetivo de erradicar a Hanseníase.

  3. A concepção de "espaço" na investigação epidemiológica

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    Maria da Conceição Nascimento Costa

    Full Text Available As atuais fragilidades conceituais e metodológicas da epidemiologia são fatores que têm restringido o estudo dos fenômenos de saúde das coletividades humanas. Neste artigo alguns princípios básicos são apresentados como resultado da observação do percurso da geografia na definição do seu objeto o espaço e da sua aplicação na medicina e na epidemiologia. Esses princípios fundamentam a pertinência da estratégia conceitual e metodológica que tem como perspectiva a abordagem do espaço geográfico-social, já que este é entendido como expressão das condições de vida da população. A aplicação desse conceito na prática da investigação epidemiológica ainda é limitada, embora outras áreas do conhecimento já tenham desenvolvido propostas de superação. Os estudos de agregados, cuja unidade de análise é o grupo, mais freqüentemente os agregados espaciais, e o modelo ecológico que se baseia na idéia de inter-relação de fatores, se aperfeiçoados, podem vir a ser uma alternativa promissora nesta direção. Destaca-se que a totalidade deve ser a referência científica, visando garantir o não afastamento dos complexos processos interativos determinantes dos fenômenos de saúde na população.

  4. A concepção de "espaço" na investigação epidemiológica

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    Costa Maria da Conceição Nascimento

    1999-01-01

    Full Text Available As atuais fragilidades conceituais e metodológicas da epidemiologia são fatores que têm restringido o estudo dos fenômenos de saúde das coletividades humanas. Neste artigo alguns princípios básicos são apresentados como resultado da observação do percurso da geografia na definição do seu objeto ­ o espaço ­ e da sua aplicação na medicina e na epidemiologia. Esses princípios fundamentam a pertinência da estratégia conceitual e metodológica que tem como perspectiva a abordagem do espaço geográfico-social, já que este é entendido como expressão das condições de vida da população. A aplicação desse conceito na prática da investigação epidemiológica ainda é limitada, embora outras áreas do conhecimento já tenham desenvolvido propostas de superação. Os estudos de agregados, cuja unidade de análise é o grupo, mais freqüentemente os agregados espaciais, e o modelo ecológico que se baseia na idéia de inter-relação de fatores, se aperfeiçoados, podem vir a ser uma alternativa promissora nesta direção. Destaca-se que a totalidade deve ser a referência científica, visando garantir o não afastamento dos complexos processos interativos determinantes dos fenômenos de saúde na população.

  5. Perfil epidemiológico de la discapacidad por accidentes de tránsito en el Perú, 2012

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    César Gutiérrez

    Full Text Available Objetivos. Describir el perfil epidemiológico de las personas discapacitadas por accidentes de tránsito (AT en Perú. Materiales y métodos. Análisis secundario de la Encuesta Nacional Especializada Sobre Discapacidad (ENEDIS del año 2012. Además, se realizó un análisis ecológico con los registros de AT del Ministerio de Transportes y Comunicaciones. Resultados. 49 036 personas reportaron algún tipo de discapacidad por accidentes de tránsito (DAT; 81,3% de los discapacitados reside en zonas urbanas. La discapacidad reportada más frecuente fue limitación en la locomoción y destreza (77,4%, seguida de la discapacidad visual (22,9%. Se reporta dependencia en 44,7% de las personas con discapacidad. Las regiones con mayor prevalencia de AT presentan mayor prevalencia de discapacidad por accidente de tránsito (Coeficiente de Spearman: 0,426, p=0,034. Conclusiones. La mayor parte de los discapacitados por AT proceden de la zona urbana, son varones y se encuentran en la edad económicamente productiva. La forma más común de limitación es la de locomoción. Gran parte de los afectados no reciben ningún tipo de rehabilitación, lo que acentúa la inequidad en salud relacionada a los accidentes de tránsito

  6. Classificação orientada a objeto de imagens de sensoriamento remoto em estudos epidemiológicos sobre leishmaniose visceral em área urbana

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    Andréa Sobral de Almeida

    2014-08-01

    Full Text Available Neste estudo, explorou-se o uso da classificação orientada a objeto de imagens de sensoriamento remoto em estudos epidemiológicos sobre leishmaniose visceral (LV em áreas urbanas. A classificação orientada a objeto foi aplicada a cenas Landsat 5 TM da cidade de Teresina, Piauí, Brasil, para obtenção de informações ambientais e temperatura. Para o período de 1993-1996, a taxa de incidência de LV nos setores censitários da cidade foi positivamente correlacionada com a área do setor censitário coberta por vegetação densa, rasteira e solo exposto e negativamente com a área coberta por água e áreas densamente ocupadas. No período de 2001-2006, foram encontradas correlações positivas com vegetação densa, rasteira, solo exposto e áreas densamente ocupadas e negativas com áreas urbanas com alguma vegetação. A temperatura da superfície terrestre foi negativamente associada à incidência de LV nos dois períodos. A classificação orientada a objeto pode ser útil para caracterizar paisagens associadas à ocorrência da LV em áreas urbanas e delimitar áreas de risco para definição de prioridades na implementação de intervenções.

  7. Use of biomarkers in ALS drug development and clinical trials.

    Science.gov (United States)

    Bakkar, Nadine; Boehringer, Ashley; Bowser, Robert

    2015-05-14

    The past decade has seen a dramatic increase in the discovery of candidate biomarkers for ALS. These biomarkers typically can either differentiate ALS from control subjects or predict disease course (slow versus fast progression). At the same time, late-stage clinical trials for ALS have failed to generate improved drug treatments for ALS patients. Incorporation of biomarkers into the ALS drug development pipeline and the use of biologic and/or imaging biomarkers in early- and late-stage ALS clinical trials have been absent and only recently pursued in early-phase clinical trials. Further clinical research studies are needed to validate biomarkers for disease progression and develop biomarkers that can help determine that a drug has reached its target within the central nervous system. In this review we summarize recent progress in biomarkers across ALS model systems and patient population, and highlight continued research directions for biomarkers that stratify the patient population to enrich for patients that may best respond to a drug candidate, monitor disease progression and track drug responses in clinical trials. It is crucial that we further develop and validate ALS biomarkers and incorporate these biomarkers into the ALS drug development process. This article is part of a Special Issue entitled ALS complex pathogenesis. Copyright © 2014 Elsevier B.V. All rights reserved.

  8. The current status of biomarkers for predicting toxicity

    Science.gov (United States)

    Campion, Sarah; Aubrecht, Jiri; Boekelheide, Kim; Brewster, David W; Vaidya, Vishal S; Anderson, Linnea; Burt, Deborah; Dere, Edward; Hwang, Kathleen; Pacheco, Sara; Saikumar, Janani; Schomaker, Shelli; Sigman, Mark; Goodsaid, Federico

    2013-01-01

    Introduction There are significant rates of attrition in drug development. A number of compounds fail to progress past preclinical development due to limited tools that accurately monitor toxicity in preclinical studies and in the clinic. Research has focused on improving tools for the detection of organ-specific toxicity through the identification and characterization of biomarkers of toxicity. Areas covered This article reviews what we know about emerging biomarkers in toxicology, with a focus on the 2012 Northeast Society of Toxicology meeting titled ‘Translational Biomarkers in Toxicology.’ The areas covered in this meeting are summarized and include biomarkers of testicular injury and dysfunction, emerging biomarkers of kidney injury and translation of emerging biomarkers from preclinical species to human populations. The authors also provide a discussion about the biomarker qualification process and possible improvements to this process. Expert opinion There is currently a gap between the scientific work in the development and qualification of novel biomarkers for nonclinical drug safety assessment and how these biomarkers are actually used in drug safety assessment. A clear and efficient path to regulatory acceptance is needed so that breakthroughs in the biomarker toolkit for nonclinical drug safety assessment can be utilized to aid in the drug development process. PMID:23961847

  9. Evaluating biomarkers for prognostic enrichment of clinical trials.

    Science.gov (United States)

    Kerr, Kathleen F; Roth, Jeremy; Zhu, Kehao; Thiessen-Philbrook, Heather; Meisner, Allison; Wilson, Francis Perry; Coca, Steven; Parikh, Chirag R

    2017-12-01

    A potential use of biomarkers is to assist in prognostic enrichment of clinical trials, where only patients at relatively higher risk for an outcome of interest are eligible for the trial. We investigated methods for evaluating biomarkers for prognostic enrichment. We identified five key considerations when considering a biomarker and a screening threshold for prognostic enrichment: (1) clinical trial sample size, (2) calendar time to enroll the trial, (3) total patient screening costs and the total per-patient trial costs, (4) generalizability of trial results, and (5) ethical evaluation of trial eligibility criteria. Items (1)-(3) are amenable to quantitative analysis. We developed the Biomarker Prognostic Enrichment Tool for evaluating biomarkers for prognostic enrichment at varying levels of screening stringency. We demonstrate that both modestly prognostic and strongly prognostic biomarkers can improve trial metrics using Biomarker Prognostic Enrichment Tool. Biomarker Prognostic Enrichment Tool is available as a webtool at http://prognosticenrichment.com and as a package for the R statistical computing platform. In some clinical settings, even biomarkers with modest prognostic performance can be useful for prognostic enrichment. In addition to the quantitative analysis provided by Biomarker Prognostic Enrichment Tool, investigators must consider the generalizability of trial results and evaluate the ethics of trial eligibility criteria.

  10. Biomarker Production and Preservation on Europa

    Science.gov (United States)

    Buffo, J.; Schmidt, B. E.

    2017-12-01

    Future landing site selection and sampling techniques for Europa will concentrate on locations of high potential biomarker preservation, however it is unclear what the best targets might be. On Europa, the scenario is quite unlike the depositional surface environments of terrestrial planets we've studied thus far-Europa's surface is passively communicating with putative habitable niches below that extend throughout the ice shell, ocean and sea floor. In this work, I approach biomarker production and preservation on Europa based by considering the many hypotheses that govern the its habitability, the processes that occur within the sea floor, ocean, and ice and exchange between them, and the geologic hypotheses for the formation of its various surfaces to establish, what journey through the planet a biomarker might take to arrive, if possible, at the surface where it is accessible to near-term landed missions. The goal of this project is to construct a simple model through which to consider the context for sampled material that will provide us with the ability to identify limitations in our intuition, understanding of the Europan system, our current hypotheses and data, and provide a road map for developing both areas for new research and identifying technology gaps that we must overcome before we can confidently select a landing site or analyze a sample from the near surface of Europa. I first consider the nature of the environment, i.e. at the sea floor interface, the ocean, or ocean-ice interface, in order to establish what the likely "biomarker" could be and then trace its path through the system: downwelling through the shell, mixing through the ocean, and pathways to the surface. Importantly, many models exist for the production of Europa's surface and subsurface geology that could affect the integrity of a putative biomarker. Often we modulate such considerations as a function of the time-scales over which the geologic process occurs, however such processes

  11. Cocktail effects on biomarker responses in fish

    Energy Technology Data Exchange (ETDEWEB)

    Celander, Malin C., E-mail: malin.celander@zool.gu.se [University of Gothenburg, Department of Zoology, Box 463, SE-405 30 Gothenburg (Sweden)

    2011-10-15

    One of today's greatest challenges in environmental toxicology is to understand effects of mixture toxicity, commonly referred to as cocktail effects, in humans and in wildlife. Biomarker responses in fish are routinely used to assess exposure of anthropogenic chemicals in the aquatic environment. However, little is known about how cocktail effects affect these biomarker responses. For this reason, there is an obvious risk for misinterpretation of biomarker-data and this can have profound negative effects on stakeholder's decisions and actions, as well as on legislations and remediation-plans initiated in order to reduce exposure to certain chemicals. Besides, chemical safety-levels are traditionally based on experiences from lab-studies with single chemicals, which is unfortunate as a chemical can be more toxic when it is mixed with other chemicals, because of the cocktail effect. This review focuses on pharmacokinetic interactions between different classes of pollutants on detoxification mechanisms and how that affects two commonly used biomarkers in the aquatic environment: (1) induction of cytochrome P450 1A (CYP1A) that is mediated via activation of the arylhydrocarbon receptor (AhR), used to assess exposure to aromatic hydrocarbons; (2) induction of vitellogenin (VTG) that is mediated via activation of the estrogen receptor (ER), used to assess exposure to estrogenic chemicals. These responses can be either directly or indirectly affected by the presence of other classes of pollutants as a result of cocktail effects. For example, chemicals that inhibit the function of key metabolic enzymes and transporter pumps that are involved in elimination of AhR- and ER agonists, can result in bioaccumulation of aromatic hydrocarbons and estrogenic chemicals resulting in increased biomarker responses. This cocktail effect can lead to overestimation of the actual exposure pressure. On the contrary, induction of expression of key metabolic enzymes and transporter

  12. Tempos históricos, tempos físicos, tempos epidemiológicos: prováveis contribuições de Fernand Braudel e Ilya Prigogine ao pensamento epidemiológico Historical times, physical times, epidemiological times: probable contributions of Fernand Braudel and Ilya Prigogine to epidemiological thinking

    Directory of Open Access Journals (Sweden)

    Gil Sevalho

    1997-01-01

    Full Text Available O texto é uma abordagem acerca do tempo enquanto categoria científica para a epidemiologia. A partir do aforismo tempo-lugar-pessoa, o tempo é apontado como elemento pouco pensado pela epidemiologia, embora esteja presente em vários dos seus conceitos. No entanto, o tema tem sido objeto de reflexão importante na movimentação recente de várias disciplinas, tais como a história, a geografia, a biologia e a física, e deve por isto representar para a epidemiologia um ponto de vista interessante, tanto no que concerne ao diálogo interdisciplinar quanto ao estabelecimento de um olhar crítico voltado para a própria disciplina. Com o objetivo de argumentar a respeito destes aspectos, apresenta-se o tempo histórico de Fernand Braudel e o tempo físico de Ilya Prigogine, construções teóricas que serão comparadas com um provável tempo epidemiológico. Ao final, usando a questão das infecções emergentes como exemplo, faz-se considerações sobre a aparente inadequação epistemológica do tempo epidemiológico para reconhecer e lidar com os aspectos sociais e históricos envolvidos na complexidade do adoecer humano coletivo.The text is an approach on time as a scientific category in epidemiology. Considering the aphorism time-place-person, time is pointed out as an element with little theoretical concern, despite its presence in main epidemiological concepts. While a topic connected to important changes in other disciplines, such as history, geography, biology and physics, time represents an interesting point of view to the interdisciplinary dialogue and its relevance for a critical knowledge in epidemiology. To argue about this idea, the historical and physical time constructions of Fernand Braudel and Ilya Prigogine are presented. These time theoretical constructions are compared with a probable epidemiological time. Finally, using the emerging infectious diseases as an example, some considerations are made about an apparent

  13. Biomarkers in spinal cord compression Ethics and perspectives

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    Iencean A.St.

    2016-09-01

    Full Text Available The phosphorylated form of the high-molecular-weight neurofilament subunit NF-H (pNF-H in serum or in cerebro-spinal fluid (CSF is a specific lesional biomarker for spinal cord injury. The lesional biomarkers and the reaction biomarkers are both presented after several hours post-injury. The specific predictive patterns of lesional biomarkers could be used to aid clinicians with making a diagnosis and establishing a prognosis, and evaluating therapeutic interventions. Diagnosis, prognosis, and treatment guidance based on biomarker used as a predictive indicator can determine ethical difficulties by differentiated therapies in patients with spinal cord compression. At this point based on studies until today we cannot take a decision based on biomarker limiting the treatment of neurological recovery in patients with complete spinal cord injury because we do not know the complexity of the biological response to spinal cord compression.

  14. Biomarkers of Aging: From Function to Molecular Biology

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    Karl-Heinz Wagner

    2016-06-01

    Full Text Available Aging is a major risk factor for most chronic diseases and functional impairments. Within a homogeneous age sample there is a considerable variation in the extent of disease and functional impairment risk, revealing a need for valid biomarkers to aid in characterizing the complex aging processes. The identification of biomarkers is further complicated by the diversity of biological living situations, lifestyle activities and medical treatments. Thus, there has been no identification of a single biomarker or gold standard tool that can monitor successful or healthy aging. Within this short review the current knowledge of putative biomarkers is presented, focusing on their application to the major physiological mechanisms affected by the aging process including physical capability, nutritional status, body composition, endocrine and immune function. This review emphasizes molecular and DNA-based biomarkers, as well as recent advances in other biomarkers such as microRNAs, bilirubin or advanced glycation end products.

  15. The Wide and Complex Field of NAFLD Biomarker Research: Trends.

    Science.gov (United States)

    Wichro, Erika; Macheiner, Tanja; Schmid, Jasmin; Kavsek, Barbara; Sargsyan, Karine

    2014-01-01

    Background. Nonalcoholic fatty liver disease is now acknowledged as a complex public health issue linked to sedentary lifestyle, obesity, and related disorders like type 2 diabetes and metabolic syndrome. Aims. We aimed to retrieve its trends out of the huge amount of published data. Therefore, we conducted an extensive literature search to identify possible biomarker and/or biomarker combinations by retrospectively assessing and evaluating common and novel biomarkers to predict progression and prognosis of obesity related liver diseases. Methodology. We analyzed finally 62 articles accounting for 157 cohorts and 45,288 subjects. Results. Despite the various approaches, most cohorts were considerably small and rarely comparable. Also, we found that the same standard parameters were measured rather than novel biomarkers. Diagnostics approaches appeared incomparable. Conclusions. Further collaborative investigations on harmonizing ways of data acquisition and identifying such biomarkers for clinical use are necessary to yield sufficient significant results of potential biomarkers.

  16. Plasma proteomics to identify biomarkers - Application to cardiovascular diseases

    DEFF Research Database (Denmark)

    Beck, Hans Christian; Overgaard, Martin; Melholt Rasmussen, Lars

    2015-01-01

    There is an unmet need for new cardiovascular biomarkers. Despite this only few biomarkers for the diagnosis or screening of cardiovascular diseases have been implemented in the clinic. Thousands of proteins can be analysed in plasma by mass spectrometry-based proteomics technologies. Therefore......, this technology may therefore identify new biomarkers that previously have not been associated with cardiovascular diseases. In this review, we summarize the key challenges and considerations, including strategies, recent discoveries and clinical applications in cardiovascular proteomics that may lead...

  17. The Wide and Complex Field of NAFLD Biomarker Research: Trends

    OpenAIRE

    Wichro, Erika; Macheiner, Tanja; Schmid, Jasmin; Kavsek, Barbara; Sargsyan, Karine

    2014-01-01

    Background. Nonalcoholic fatty liver disease is now acknowledged as a complex public health issue linked to sedentary lifestyle, obesity, and related disorders like type 2 diabetes and metabolic syndrome. Aims. We aimed to retrieve its trends out of the huge amount of published data. Therefore, we conducted an extensive literature search to identify possible biomarker and/or biomarker combinations by retrospectively assessing and evaluating common and novel biomarkers to predict progression a...

  18. Características clínicas y epidemiológicas de enterobiasis en niños escolarizados de una zona rural del estado falcón, Venezuela

    OpenAIRE

    PERFETTI, DALMIRO CAZORLA; ACOSTA-QUINTERO, MARÍA; MORALES-MORENO, PEDRO

    2016-01-01

    El entero-helminto Enterobius vermicularis es el agente causal de la enterobiasis u oxiuriasis, la cual se encuentra con mayor prevalencia en niños. Se realizó un estudio para determinar la prevalencia y los parámetros clínicos y epidemiológicos de la enterobiasis en niños escolarizados de la población rural El Paso Acurigua, estado Falcón, Venezuela. El estudio de tipo descriptivo, prospectivo y transversal, se llevó a cabo entre noviembre 2006 y abril de 2007, en un total de 82 niños. Para ...

  19. Diabetes tipo 2 en niños y adolescentes: aspectos clínico-epidemiológicos, patogénicos y terapéuticos Type 2 diabetes mellitus in children and adolescents: clinicoepidemiological, pathogenic and therapeutic aspects

    OpenAIRE

    Manuel Emiliano Licea Puig; Mirelkis Bustamante Teijido; Maritza Lemane Pérez

    2008-01-01

    OBJETIVO: debido al incremento sostenido en la incidencia de la diabetes mellitus tipo 2 en personas < 20 años, nos proponemos revisar aspectos clínico-epidemiológicos, patogénicos y terapéuticos de la diabetes mellitus tipo 2 en niños y adolescentes. DESARROLLO: en la infancia, se estima que la diabetes mellitus tipo 2 representa del 2-3 % de todos los casos. Sin embargo, en los últimos años ha mostrado un incremento de 10 veces. Su prevalencia es mayor en afroamericanos, hispanos y nativos ...

  20. Características epidemiológicas de la neumonía intrahospitalaria en un servicio de medicina interna del Hospital Guillermo Almenara Irigoyen de Lima, Perú

    OpenAIRE

    León-Chahua, César; Hospital Nacional Guillermo Almenara Irigoyen-EsSalud, Lima.; Oscanoa-Espinoza, Teodoro; Hospital Nacional Guillermo Almenara Irigoyen-EsSalud, Lima.; Chávez-Gutiérrez, Cynthia; Facultad de Medicina, Universidad San Martín de Porres, Lima.; Chávez-Gutiérrez, José; Facultad de Medicina, Universidad San Martín de Porres, Lima.

    2016-01-01

    Objetivo: Determinar las características epidemiológicas de los pacientes con neumonía intrahospitalaria (NIH) en un servicio de medicina interna.Material y métodos: Estudio descriptivo, retrospectivo; llevado a cabo en el servicio de medicina interna Nº 5 del Hospital Nacional Guillermo Almenara Irigoyen (HNGAI) durante el año 2015. Se revisaron las historias clínicas de pacientes mayores de 15 años con el diagnóstico de egreso de NIH que cumplieron los criterios de selección.Resultados: Se ...

  1. Desarrollo de técnicas de ADN para el diagnóstico y caracterización de "Toxoplasma gondii" : aplicación a estudios epidemiológicos

    OpenAIRE

    Fuentes Corripio, Isabel de

    1999-01-01

    Se ha estudiado la aplicación de las técnicas moleculares en el diagnóstico por medio de la detección del ADN del parásito en diversos tipos de muestras procedentes de pacientes. La alta especificidad y sensibilidad obtenida con la PCR secuencial interna destacó en el diagnóstico de la toxoplasmosis. La sensibilidad se incrementa combinando el análisis de diferentes tipos de muestras y muestras secuenciales. Se realizó el estudio epidemiológico de la toxoplasmósis gestacional en el área de Ma...

  2. Alergia a antibióticos betalactámicos. Procedimientos diagnósticos y características epidemiológicas en las poblaciones de Cantabria y Santa Cruz de Tenerife.

    OpenAIRE

    Iglesias Souto, Francisco Javier

    2016-01-01

    RESUMEN: Los antibióticos betalactámicos constituyen la causa más frecuente de alergia medicamentosa. Existe un elevado número de pacientes etiquetados como alérgicos sin haber sido estudiados. Esto genera un problema de gestión de recursos sanitarios al utilizar tratamientos antibióticos alternativos, habitualmente de menor eficacia y mayor coste económico. Estimamos realizar un estudio epidemiológico descriptivo en dos ámbitos poblacionales sobre alergia betalactámicos, para determinar la i...

  3. Características clínico, epidemiológicas de la diabetes mellitus en el adulto mayor. Policlínico Universitario Luís A Turcios Lima

    OpenAIRE

    Dot Pérez, Licet del C; Díaz Calzada, Marvelia; Pérez Labrador, Joaquín; Torres Marín, Juan de la C; Díaz Valdés, Maité

    2011-01-01

    Se realizó un estudio descriptivo y transversal, con el objetivo de determinar algunos aspectos clínicos, epidemiológicos en los adultos mayores diabéticos, en el período julio-diciembre 2007 y proponer una estrategia de intervención educativa. El universo de estudio lo constituyeron los 316 adultos mayores, del Consultorio Médico 215, del Policlínico Universitario "Luis A. Turcios Lima", municipio Pinar del Río y la muestra los 90 adultos mayores diabéticos. De la historia de salud individua...

  4. Caracterización de la historia personal epidemiológica de tuberculosis pulmonar en individuos en condiciones de movilización en la frontera Andina Norte del Ecuador

    OpenAIRE

    Durán Carranza, Ximena Jeaneth

    2015-01-01

    Contexto: La tuberculosis pulmonar es un importante problema de salud a nivel mundial. Las poblaciones que residen en zonas de frontera debido al flujo migratorio presentan factores de riesgo que favorecen la transmisión y la propagación de la enfermedad, lo que ocasiona que sea de difícil control en estos grupos vulnerables. Objetivo: Caracterizar la historia personal epidemiológica de tuberculosis pulmonar en los individuos en condiciones de movilización en la frontera Andina norte del Ecua...

  5. Caigudes en població anciana característiques epidemiològiques i utilitat clínica dels tests d'equilibri i marxa Timed up and go i Tinetti /

    OpenAIRE

    Jiménez González, Mª Mercè

    2009-01-01

    Descripció del recurs: 26 gener 2010 Objectiu: 1-Conèixer la capacitat predictiva i la utilitat clínica per predir caigudes de dos tests d'equilibri i marxa "Timed up go" i Tinetti en població geriàtrica ambulatòria 65 anys. 2-Conèixer la incidència,característiques epidemiològiques, i factors de risc que estan relacionats amb major risc de caigudes en el nostre medi. Estudi: Cohorts prospectiu multicèntric. Subjectes: 555 pacients majors de 65 anys visitats en els centres de salut del...

  6. Caigudes en població anciana comunitària: característiques epidemiològiques i utilitat clínica dels tests d'equilibri i marxa Timed up and go i Tinetti

    OpenAIRE

    Jiménez González, Mª Mercè

    2009-01-01

    Objectiu: 1-Conèixer la capacitat predictiva i la utilitat clínica per predir caigudes de dos tests d'equilibri i marxa "Timed up & go" i Tinetti en població geriàtrica ambulatòria ≥65 anys. 2-Conèixer la incidència,característiques epidemiològiques, i factors de risc que estan relacionats amb major risc de caigudes en el nostre medi.Estudi: Cohorts prospectiu multicèntric. Subjectes: 555 pacients majors de 65 anys visitats en els centres de salut del Maresme (Alella, Mataró, Premià i C...

  7. Avaliação da eficácia da lasalocida e de alguns fatores epidemiológicos de Eimeria spp. parasitando bezerros Nelore mantidos em regime de pastejo

    OpenAIRE

    Cruvinel, Leonardo Bueno; Borges, Dyego Gonçalves Lino; Nicaretta, João Eduardo; Bastos, Thiago Souza Azeredo; Moro, Elio; Gama, Rogério Dantas; Borges, Fernando de Almeida; Lopes, Welber Daniel Zanetti

    2017-01-01

    RESUMO: A principal importância da eimeriose em bovinos, se deve ao baixo desempenho produtivo que os animais demonstram quando esta enfermidade apresenta-se sob a forma sub-clínica. Como objetivos, o presente trabalho avaliou a eficácia do uso da lasalocida sódica contra espécies de Eimeria spp. parasitando bezerros; avaliou também o desempenho ponderal dos animais submetidos aos diferentes tratamentos e analisou alguns fatores epidemiológicos que possam interferir na infecção por Eimeria no...

  8. Evolución de los conocimientos sobre aspectos clínico-epidemiológicos de la Coccidioidomycosis en las Américas Historical evolution of some clinical and epidemiological knowledge of coccidioidomycosis in the Americas

    OpenAIRE

    R. Negroni

    2008-01-01

    La coccidioidomicosis es una micosis sistémica endémica exclusiva de América, producida por dos especies de hongos dimorfos del género Coccidioides: Coccidioides immitis y Coccidioides posadasii. En este artículo se presenta una revisión histórica de la evolución de los conocimientos sobre la coccidioidomicosis en varios países del continente americano. La mayor parte de los hallazgos epidemiológicos, patogénicos, clínicos y terapéuticos se realizaron en los EE. UU. La enfermedad fue descubie...

  9. Caracterización epidemiológica de la infección respiratoria aguda grave y circulación viral en Boyacá, julio de 2012 a julio de 2013

    OpenAIRE

    García García, Constanza Marcela

    2014-01-01

    Objetivo. Caracterizar clínica y epidemiológicamente la Infección respiratoria aguda grave y circulación viral en Boyacá a partir de la vigilancia centinela entre Julio de 2012 y Julio de 2013. Metodología. Estudio descriptivo a partir de información del Sistema de Vigilancia en Salud Pública. La población estuvo conformada por 530 casos con muestra de hisopado nasofaríngeo de las Instituciones centinela en Tunja, las muestras se procesaron por inmunofluorescencia indirecta ...

  10. Patrón epidemiológico del consumo de droga mediante el análisis de cabello efectuado en el departamento de Madrid del Instituto Nacional de Toxicología y Ciencias Forenses, 2013-2015

    OpenAIRE

    Burgueño Arjona, María José

    2017-01-01

    [ES] El abuso y dependencia de sustancias psicoactivas constituyen un problema prioritario de salud pública que se pone de manifiesto subjetivamente en el hecho de que las drogas se encuentran entre los problemas que más preocupan a la sociedad actual y se confirma mediante los datos epidemiológicos. Las consecuencias del consumo de drogas son graves tanto para el individuo como para la sociedad, tanto en términos sanitarios como socioeconómicos, y las soluciones a este problema se escapa...

  11. Características clínico-epidemiológicas de pacientes con cólera en la ciudad de México Clinical and epidemiological characteristics of cholera patients in Mexico City

    OpenAIRE

    Agustina Elena Vilchis-Guizar; Samuel Uribe-Márquez; Patricia Leonor Pérez-Sánchez

    1999-01-01

    OBJETIVO: Comparar las características clínico-epidemiológicas de enfermos de cólera (casos) con las de pacientes con diarrea por otra causa (no casos), atendidos en las unidades médicas de la Delegación 2 Noreste del Distrito Federal, del Instituto Mexicano del Seguro Social (IMSS). MATERIAL Y MÉTODOS: Se realizó un estudio transversal analítico y se utilizaron datos de 4 952 notificaciones reunidas entre 1995 y 1998 a través del formato oficial "Hoja de notificación inmediata de casos de có...

  12. Coronavírus em codornas: ocorrência, diversidade molecular e estudo do papel epidemiológico das codornas como reservatório para a bronquite infecciosa das galinhas

    OpenAIRE

    Carolina Torres Alejo

    2012-01-01

    Este estudo teve como objetivo pesquisar a ocorrência e diversidade molecular de coronavírus aviários em codornas e galinhas criadas nas mesmas propriedades e determinar o papel epidemiológico das codornas na bronquite infecciosa das galinhas (BIG). Para isso, foram coletados em granjas localizadas no estado de São Paulo e Espírito Santo pools de aparelho reprodutivo, pulmões, rins, traquéia e conteúdo entérico de codornas e galinhas com histórico de manifestações clínicas compatíveis com BIG...

  13. Epidemiologists working together with anthropologists: lessons from a study to evaluate the epidemiological impact of a city-wide sanitation program Los epidemiólogos y antropólogos que trabajan juntos: lecciones de un estudio para evaluar el impacto epidemiológico de un programa de saneamiento urbano Epidemiologistas e antropólogos trabalhando juntos: lições de um estudo para avaliar o impacto epidemiológico de um programa de saneamento urbano

    Directory of Open Access Journals (Sweden)

    Mauricio L. Barreto

    2013-03-01

    Full Text Available This paper discusses the role of qualitative approaches in epidemiological studies, beginning with a general discussion of epidemiological and anthropological methods. It focuses on a case study of the health impact of an environmental intervention carried out in Salvador, Bahia State, Brazil. Most of the precedent studies fields, based on primary date, use to devote little attention to the methodological and theorethical questions attached to long-term studies. Four specific aspects of this experience are highlighted: (a drawing up epidemiological study; (b construction of an observational instrument to measure hygiene habits; (c an ethnographic study that was carried out before the epidemiological study; (d observation of the effects of health intervention on health inequalities. Finally, the report details how the findings of qualitative and quantitative studies might be synthesized. It provides a critical overview of follow-up strategies, illustrated with proper examples whenever possible.En este artículo se discute el papel de los enfoques cualitativos en los estudios epidemiológicos, comenzando con una discusión general de ambos métodos. Se centra en un estudio de caso sobre el impacto en la salud de una intervención ambiental en Salvador, Bahía, Brasil. La mayoría de los estudios en esta línea, que se deriven de la fuente principal de la investigación, aporta poca discusión sobre los aspectos metodológicos y teóricos que participan en estudios a largo plazo. Cuatro aspectos específicos de esta experiencia son especialmente prominentes: (a elaboración de cuestionarios para el estudio epidemiológico; (b la construcción de un instrumento para medir los hábitos de higiene de observación; (c un estudio etnográfico que precedió a la investigación epidemiológica; (d observación de los efectos de las intervenciones sanitarias sobre las desigualdades en salud. Por último, el estudio considera en detalle cómo los resultados

  14. Impact of biomarker development on drug safety assessment

    International Nuclear Information System (INIS)

    Marrer, Estelle; Dieterle, Frank

    2010-01-01

    Drug safety has always been a key aspect of drug development. Recently, the Vioxx case and several cases of serious adverse events being linked to high-profile products have increased the importance of drug safety, especially in the eyes of drug development companies and global regulatory agencies. Safety biomarkers are increasingly being seen as helping to provide the clarity, predictability, and certainty needed to gain confidence in decision making: early-stage projects can be stopped quicker, late-stage projects become less risky. Public and private organizations are investing heavily in terms of time, money and manpower on safety biomarker development. An illustrative and 'door opening' safety biomarker success story is the recent recognition of kidney safety biomarkers for pre-clinical and limited translational contexts by FDA and EMEA. This milestone achieved for kidney biomarkers and the 'know how' acquired is being transferred to other organ toxicities, namely liver, heart, vascular system. New technologies and molecular-based approaches, i.e., molecular pathology as a complement to the classical toolbox, allow promising discoveries in the safety biomarker field. This review will focus on the utility and use of safety biomarkers all along drug development, highlighting the present gaps and opportunities identified in organ toxicity monitoring. A last part will be dedicated to safety biomarker development in general, from identification to diagnostic tests, using the kidney safety biomarkers success as an illustrative example.

  15. Imaging biomarkers as surrogate endpoints for drug development

    International Nuclear Information System (INIS)

    Richter, Wolf S.

    2006-01-01

    The employment of biomarkers (including imaging biomarkers, especially PET) in drug development has gained increasing attention during recent years. This has been partly stimulated by the hope that the integration of biomarkers into drug development programmes may be a means to increase the efficiency and effectiveness of the drug development process by early identification of promising drug candidates - thereby counteracting the rising costs of drug development. More importantly, however, the interest in biomarkers for drug development is the logical consequence of recent advances in biosciences and medicine which are leading to target-specific treatments in the framework of ''personalised medicine''. A considerable proportion of target-specific drugs will show effects in subgroups of patients only. Biomarkers are a means to identify potential responders, or patient subgroups at risk for specific side-effects. Biomarkers are used in early drug development in the context of translational medicine to gain information about the drug's potential in different patient groups and disease states. The information obtained at this stage is mainly important for designing subsequent clinical trials and to identify promising drug candidates. Biomarkers in later phases of clinical development may - if properly validated - serve as surrogate endpoints for clinical outcomes. Regulatory agencies in the EU and the USA have facilitated the use of biomarkers early in the development process. The validation of biomarkers as surrogate endpoints is part of FDA's ''critical path initiative''. (orig.)

  16. [Collaborative projects with academia for regulatory science studies on biomarkers].

    Science.gov (United States)

    Saito, Yoshiro; Nakamura, Ryosuke; Maekawa, Keiko

    2014-01-01

    Biomarkers are useful tools to be utilized as indicators/predictors of disease severity and drug responsiveness/safety, and thus are expected to promote efficient drug development and to accelerate proper use of approved drugs. Many academic achievements have been reported, but only a small number of biomarkers are used in clinical trials and drug treatments. Regulatory sciences on biomarkers for their secure development and proper qualification are necessary to facilitate their practical application. We started to collaborate with Tohoku University and Nagoya City University for sample quality, biomarker identification, evaluation of their usage, and making guidances. In this short review, scheme and progress of these projects are introduced.

  17. The economics of cardiac biomarker testing in suspected myocardial infarction.

    Science.gov (United States)

    Goodacre, Steve; Thokala, Praveen

    2015-03-01

    Suspected myocardial infarction (MI) is a common reason for emergency hospital attendance and admission. Cardiac biomarker measurement is an essential element of diagnostic assessment of suspected MI. Although the cost of a routinely available biomarker may be small, the large patient population and consequences in terms of hospital admission and investigation mean that the economic impact of cardiac biomarker testing is substantial. Economic evaluation involves comparing the estimated costs and effectiveness (outcomes) of two or more interventions or care alternatives. This process creates some difficulties with respect to cardiac biomarkers. Estimating the effectiveness of cardiac biomarkers involves identifying how they help to improve health and how we can measure this improvement. Comparison to an appropriate alternative is also problematic. New biomarkers may be promoted on the basis of reducing hospital admission or length of stay, but hospital admission for low risk patients may incur significant costs while providing very little benefit, making it an inappropriate comparator. Finally, economic evaluation may conclude that a more sensitive biomarker strategy is more effective but, by detecting and treating more cases, is also more expensive. In these circumstances it is unclear whether we should use the more effective or the cheaper option. This article provides an introduction to health economics and addresses the specific issues relevant to cardiac biomarkers. It describes the key concepts relevant to economic evaluation of cardiac biomarkers in suspected MI and highlights key areas of uncertainty and controversy. Copyright © 2014 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.

  18. Breast Cancer Biomarkers Based on Nipple and Fine Needle Aspirates

    National Research Council Canada - National Science Library

    Torosian, Michael

    2000-01-01

    .... These biomarkers include: cytology, DNA index, cell cycle parameters, proliferation index, epidermal growth factor receptor overexpression, p53 and RAS hotspot mutations and hypermethylation of specific gene products...

  19. Inflammasome Proteins As Biomarkers of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Robert W. Keane

    2018-03-01

    Full Text Available Multiple sclerosis (MS is an autoimmune disease that affects the brain and spinal cord. The inflammasome is a multiprotein complex that contributes to the innate immune response in animal models of MS as well as in patients with the disease. Important to the care of patients with MS is the need for biomarkers that can predict disease onset, disease exacerbation, as well as response to treatment. In this study, we analyzed serum samples from 32 patients with MS and 120 age-matched controls, and provide receiver operator characteristic (ROC curves with associated confidence intervals following analyses of serum samples from patients with MS, most of which had the relapsing-remitting form of the disease, and from healthy unaffected donors, and determine the sensitivity and specificity of inflammasome proteins as biomarkers of MS. We report that caspase-1 (1.662 ± 0.6024 difference between means, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC (407.5 ± 35.79, and interleukin (IL-18 (78.53 + 17.86 were elevated in the serum of MS patients when compared to controls. Interestingly, the levels of IL-1β (−0.5961 ± 0.265 were lower in the MS cohort. Importantly, the area under the curve (AUC for ASC and caspase-1 were 0.9448 and 0.848, respectively. Taken together, these data suggest that ASC and caspase-1 could be potential candidate biomarkers for MS onset.

  20. Autologous Blood Transfusion in Sports: Emerging Biomarkers.

    Science.gov (United States)

    Salamin, Olivier; De Angelis, Sara; Tissot, Jean-Daniel; Saugy, Martial; Leuenberger, Nicolas

    2016-07-01

    Despite being prohibited by the World Anti-Doping Agency, blood doping through erythropoietin injection or blood transfusion is frequently used by athletes to increase oxygen delivery to muscles and enhance performance. In contrast with allogeneic blood transfusion and erythropoietic stimulants, there is presently no direct method of detection for autologous blood transfusion (ABT) doping. Blood reinfusion is currently monitored with individual follow-up of hematological variables via the athlete biological passport, which requires further improvement. Microdosage is undetectable, and suspicious profiles in athletes are often attributed to exposure to altitude, heat stress, or illness. Additional indirect biomarkers may increase the sensitivity and specificity of the longitudinal approach. The emergence of "-omics" strategies provides new opportunities to discover biomarkers for the indirect detection of ABT. With the development of direct quantitative methods, transcriptomics based on microRNA or messenger RNA expression is a promising approach. Because blood donation and blood reinfusion alter iron metabolism, quantification of proteins involved in metal metabolism, such as hepcidin, may be applied in an "ironomics" strategy to improve the detection of ABT. As red blood cell (RBC) storage triggers changes in membrane proteins, proteomic methods have the potential to identify the presence of stored RBCs in blood. Alternatively, urine matrix can be used for the quantification of the plasticizer di(2-ethyhexyl)phthalate and its metabolites that originate from blood storage bags, suggesting recent blood transfusion, and have an important degree of sensitivity and specificity. This review proposes that various indirect biomarkers should be applied in combination with mathematical approaches for longitudinal monitoring aimed at improving ABT detection. Copyright © 2016 Elsevier Inc. All rights reserved.

  1. Biomarkers in chronic obstructive pulmonary disease

    DEFF Research Database (Denmark)

    Sin, Don D; Vestbo, Jørgen

    2009-01-01

    Currently, with exception of lung function tests, there are no well validated biomarkers or surrogate endpoints that can be used to establish efficacy of novel drugs for chronic obstructive pulmonary disease (COPD). However, the lung function test is not an ideal surrogate for short-term drug...... trials because it (1) does not provide information regarding disease activity or the underlying pathologic process, (2) cannot separate the various phenotypes of COPD, (3) is not specific for COPD, and (4) is relatively unresponsive to known therapies that prolong survival. Accordingly, there are large...

  2. Exhaled Breath Condensate for Proteomic Biomarker Discovery

    Directory of Open Access Journals (Sweden)

    Sean W. Harshman

    2014-07-01

    Full Text Available Exhaled breath condensate (EBC has been established as a potential source of respiratory biomarkers. Compared to the numerous small molecules identified, the protein content of EBC has remained relatively unstudied due to the methodological and technical difficulties surrounding EBC analysis. In this review, we discuss the proteins identified in EBC, by mass spectrometry, focusing on the significance of those proteins identified. We will also review the limitations surrounding mass spectral EBC protein analysis emphasizing recommendations to enhance EBC protein identifications by mass spectrometry. Finally, we will provide insight into the future directions of the EBC proteomics field.

  3. Metabolomics: beyond biomarkers and towards mechanisms

    Science.gov (United States)

    Johnson, Caroline H.; Ivanisevic, Julijana; Siuzdak, Gary

    2017-01-01

    Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases. PMID:26979502

  4. Exosomes: the future of biomarkers in medicine.

    Science.gov (United States)

    Properzi, Francesca; Logozzi, Mariantonia; Fais, Stefano

    2013-10-01

    Exosomes are nanovesicles secreted into the extracellular environment upon internal vesicle fusion with the plasma membrane. The molecular content of exosomes is a fingerprint of the releasing cell type and of its status. For this reason, and because they are released in easily accessible body fluids such as blood and urine, they represent a precious biomedical tool. A growing body of evidence suggests that exosomes may be used as biomarkers for the diagnosis and prognosis of malignant tumors. This article focuses on the exploitation of exosomes as diagnostic tools for human tumors and discusses possible applications of the same strategies to other pathologies, such as neurodegenerative diseases.

  5. Cardiac biomarkers in neonatal hypoxic ischaemia.

    LENUS (Irish Health Repository)

    Sweetman, D

    2012-04-01

    Following a perinatal hypoxic-ischaemic insult, term infants commonly develop cardiovascular dysfunction. Troponin-T, troponin-I and brain natriuretic peptide are sensitive indicators of myocardial compromise. The long-term effects of cardiovascular dysfunction on neurodevelopmental outcome following perinatal hypoxic ischaemia remain controversial. Follow-up studies are warranted to ensure optimal cardiac function in adulthood. CONCLUSION: Cardiac biomarkers may improve the diagnosis of myocardial injury, help guide management, estimate mortality risk and may also aid in longterm neurodevelopmental outcome prediction following neonatal hypoxic-ischaemia.

  6. Adiponectin as a routine clinical biomarker.

    Science.gov (United States)

    Kishida, Ken; Funahashi, Tohru; Shimomura, Iichiro

    2014-01-01

    Adiponectin is a protein synthesized and secreted predominantly by adipocytes into the peripheral blood. However, circulating adiponectin level is inversely related with body weight, especially visceral fat accumulation. The mechanism of this paradoxical relation remains obscure. Low circulating adiponectin concentrations (hypoadiponectinemia; osteoporosis, and cancer (endometrial cancer, postmenopausal breast cancer, leukemia, colon cancer, gastric cancer, prostate cancer). On the other hand, hyperadiponectinemia is associated with cardiac, renal and pulmonary diseases. This review article focuses on the significance of adiponectin as a clinical biomarker of obesity-related diseases. Routine measurement of adiponectin in patients with lifestyle-related diseases is highly recommended. Copyright © 2013 Elsevier Ltd. All rights reserved.

  7. Bayesian additive decision trees of biomarker by treatment interactions for predictive biomarker detection and subgroup identification.

    Science.gov (United States)

    Zhao, Yang; Zheng, Wei; Zhuo, Daisy Y; Lu, Yuefeng; Ma, Xiwen; Liu, Hengchang; Zeng, Zhen; Laird, Glen

    2017-10-11

    Personalized medicine, or tailored therapy, has been an active and important topic in recent medical research. Many methods have been proposed in the literature for predictive biomarker detection and subgroup identification. In this article, we propose a novel decision tree-based approach applicable in randomized clinical trials. We model the prognostic effects of the biomarkers using additive regression trees and the biomarker-by-treatment effect using a single regression tree. Bayesian approach is utilized to periodically revise the split variables and the split rules of the decision trees, which provides a better overall fitting. Gibbs sampler is implemented in the MCMC procedure, which updates the prognostic trees and the interaction tree separately. We use the posterior distribution of the interaction tree to construct the predictive scores of the biomarkers and to identify the subgroup where the treatment is superior to the control. Numerical simulations show that our proposed method performs well under various settings comparing to existing methods. We also demonstrate an application of our method in a real clinical trial.

  8. Addressing small sample size bias in multiple-biomarker trials: Inclusion of biomarker-negative patients and Firth correction.

    Science.gov (United States)

    Habermehl, Christina; Benner, Axel; Kopp-Schneider, Annette

    2018-03-01

    In recent years, numerous approaches for biomarker-based clinical trials have been developed. One of these developments are multiple-biomarker trials, which aim to investigate multiple biomarkers simultaneously in independent subtrials. For low-prevalence biomarkers, small sample sizes within the subtrials have to be expected, as well as many biomarker-negative patients at the screening stage. The small sample sizes may make it unfeasible to analyze the subtrials individually. This imposes the need to develop new approaches for the analysis of such trials. With an expected large group of biomarker-negative patients, it seems reasonable to explore options to benefit from including them in such trials. We consider advantages and disadvantages of the inclusion of biomarker-negative patients in a multiple-biomarker trial with a survival endpoint. We discuss design options that include biomarker-negative patients in the study and address the issue of small sample size bias in such trials. We carry out a simulation study for a design where biomarker-negative patients are kept in the study and are treated with standard of care. We compare three different analysis approaches based on the Cox model to examine if the inclusion of biomarker-negative patients can provide a benefit with respect to bias and variance of the treatment effect estimates. We apply the Firth correction to reduce the small sample size bias. The results of the simulation study suggest that for small sample situations, the Firth correction should be applied to adjust for the small sample size bias. Additional to the Firth penalty, the inclusion of biomarker-negative patients in the analysis can lead to further but small improvements in bias and standard deviation of the estimates. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  9. The Biomarker Knowledge System Informatics Pilot Project Supplement To The Biomarker Development Laboratory at Moffitt (Bedlam) — EDRN Public Portal

    Science.gov (United States)

    The Biomarker Knowledge System Informatics Pilot Project goal will develop network interfaces among databases that contain information about existing clinical populations and biospecimens and data relating to those specimens that are important in biomarker assay validation. This protocol comprises one of two that will comprise the Moffitt participation in the Biomarker Knowledge System Informatics Pilot Project. THIS PROTOCOL (58) is the Sput-Epi Database.

  10. Estudo epidemiológico de câncer na adolescência em centro de referência Estudio epidemiológico de cáncer en la adolescencia en centro de referencia Epidemiological study of cancer in adolescents at a referral center

    Directory of Open Access Journals (Sweden)

    Paula de Figueiredo Presti

    2012-06-01

    Full Text Available OBJETIVO: Analisar as características epidemiológicas dos adolescentes portadores de neoplasias encaminhados para o Instituto de Oncologia Pediátrica (IOP/GRAACC da Universidade Federal de São Paulo, entre os anos de 2000 a 2006. MÉTODOS: Trata-se de um estudo retrospectivo descritivo, em que foram avaliados os dados epidemiológicos dos pacientes, com idade entre dez e19 anos ao diagnóstico, admitidos do ano 2000 a 2006 no IOP/Graacc. RESULTADOS: Do total de 2.362 pacientes admitidos neste período com diagnóstico de câncer, 629 (26,6% eram adolescentes. A idade média encontrada foi de 13,8 anos, sendo a maioria do sexo masculino (56,8%. Em relação à raça, 60,7% dos pacientes eram brancos. Os tipos de tumores mais frequentes foram: tumores de sistema nervoso central (22,1%, osteossarcoma (14,6%, linfomas (14,5% e leucemias (14,5%. A sobrevida global, em cinco anos, dos 629 pacientes deste estudo foi de 73,7%. Destaca-se que os adolescentes com rabdomiossarcoma apresentavam doença disseminada e histologia de pior prognóstico, contribuindo para o aumento na taxa de mortalidade deste grupo de pacientes. CONCLUSÕES: Os adolescentes com câncer correspondem a um grupo de pacientes que apresenta características peculiares quando comparado a outros grupos oncológicos. Há diferença histológica dos tumores dos adolescentes com os da infância, em que predominam leucemias e tumores do sistema nervoso central. Nesse contexto, é fundamental facilitar o acesso desses pacientes a centros especializados e oferecer meios apropriados para o diagnóstico precoce e tratamento adequado.OBJETIVO: Analizar las características epidemiológicas de los adolescentes portadores de neoplasias encaminados al Instituto de Oncología Pediátrica (IOP/GRAACC de la Universidad Federal de São Paulo, entre los años 2000 a 2006. MÉTODOS: Se trata de un estudio retrospectivo descriptivo, en el que fueron evaluados los datos epidemiológicos de los

  11. Cobertura de linhas telefônicas residenciais e vícios potenciais em estudos epidemiológicos Cobertura de líneas telefónicas residenciales y vicios potenciales en estudios epidemiológicos Home landline telephone coverage and potential bias in epidemiological surveys

    Directory of Open Access Journals (Sweden)

    Regina Bernal

    2009-06-01

    Full Text Available OBJETIVO: Estimar o efeito da taxa de cobertura de linhas telefônicas residenciais em potenciais vícios de informação em inquéritos epidemiológicos. MÉTODOS: Foram utilizadas as bases de dados da Pesquisa Nacional por Amostra de Domicílios no período de 1998 a 2003 para a estimativa das taxas de cobertura de linhas telefônicas residenciais nas cinco regiões geográficas brasileiras. Utilizou-se a regressão logística múltipla para identificar os fatores associados à posse de linha telefônica fixa. O impacto do vício nos intervalos com 95% de confiança foi avaliado em função da precisão alcançada em cada situação. RESULTADOS: Nas regiões metropolitanas Sudeste, Sul e Centro-Oeste com 70% e mais de cobertura, os vícios associados foram considerados desprezíveis. Nas demais regiões, os vícios relativos estavam acima do limite aceitável (0,4, indicando possíveis erros nas inferências construídas sob intervalo com 95% de confiança. A chance de acesso à linha telefônica residencial foi maior para população com cor da pele branca e maior escolaridade. CONCLUSÕES: Os achados mostram que o uso de cadastro de linhas telefônicas residenciais é indicado para a realização de inquéritos epidemiológicos apenas para estados com cobertura acima de 70%. Metodologias específicas para o tratamento de estimativas obtidas em localidades com taxas inferiores, precisam ser estudadas e divulgadas.OBJETIVO: Estimar el efecto de la tasa de cobertura de líneas telefónicas residenciales en potenciales vicios de información en investigaciones epidemiológicas. MÉTODOS: Fueron utilizadas las bases de datos de la Pesquisa Nacional por Muestra de Domicilios en el período de 1998 a 2003 para la estimación de las tasas de cobertura de líneas telefónicas residenciales en las cinco regiones geográficas brasileras. Se utilizó la regresión logística múltiple para identificar los factores asociados al poseer línea telef

  12. Investigações epidemiológicas sobre demência nos países em desenvolvimento Epidemiological research on dementia in developing countries

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    M Scazufca

    2002-12-01

    Full Text Available Na medida em que a população mundial está envelhecendo, a demência está se constituindo em importante problema de saúde pública, particularmente nos países em desenvolvimento. Investigações epidemiológicas nestes países são escassas e apresentam dificuldades metodológicas adicionais, principalmente no que se refere à adequação sociocultural dos instrumentos utilizados para a definição de casos. Tendo em vista estas preocupações, foi fundado o "Grupo de Pesquisa em Demência 10/66", que é constituído por uma rede internacional de pesquisadores, predominantemente de países em desenvolvimento. O nome do grupo tem como referência o paradoxo de que menos de 10% dos estudos populacionais sobre demência são dirigidos aos 2/3 ou mais de casos de pessoas com demência que vivem em países em desenvolvimento. O objetivo do artigo é atualizar informações da literatura sobre as diferenças de prevalência e incidência de demência encontradas em países desenvolvidos e em desenvolvimento.As the world population is ageing, dementia becomes an important public health problem, particularly in developing countries. Epidemiological research in these settings is scarce and present additional methodological difficulties, mainly regarding the socio-cultural adequacy of instruments used to identify cases of dementia. As a result of these concerns the 10/66 Dementia Research Group was founded to fill this gap. This is an international network of investigators, mostly from developing countries, and the group's name was based on the paradox that less than 10% of the population-based studies on dementia are directed to 2/3 or more cases of people with dementia living in developing countries. The aim of the paper is to update data in the literature regarding the differences in dementia prevalence and incidence seen in developed and developing countries.

  13. Métodos de series temporales en los estudios epidemiológicos sobre contaminación atmosférica

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    Saez Marc

    1999-01-01

    Full Text Available Se revisan los métodos de series temporales en los estudios epidemiológicos sobre contaminación atmosférica, ilustrándolo mediante una regresión de Poisson autoregresiva, la cual ha sido utilizada en los proyectos APHEA y EMECAM. Se relacionan las variaciones en el número diario de muertos mayores de 70 años (todas las causas, CIE-9:001-799 en Barcelona, 1991-1995, con las variaciones en los niveles diarios promedio de contaminación por humos negros. Se utiliza una regresión de Poisson por cuanto la variable aleatoria dependiente sigue presumiblemente tal distribución de probabilidad. Como confusores se consideran variables meteorológicas (promedios diarios de temperatura y de humedad, comportamientos tendenciales, estacionales y efectos de calendario presentes en la mortalidad (todos ellos aproximados de forma determinista así como cualquier otra variable que tenga un comportamiento que pueda relacionarse con la variable dependiente (ocurrencia de epidemias de gripe por ejemplo. La relación entre la mortalidad y las variables confusoras se modeliza de forma no lineal y se tienen en cuenta además los previsibles periodos de latencia (utilizando retardos de variables explicativa por ejemplo. Sin embargo, y debido a que el control no es perfecto, se opta por estimar un modelo de Poisson autoregresivo (introduciendo como variables explicativas diversos retardos de la mortalidad corrigiendo la autocorrelación residual. La principal ventaja del método de análisis descrito es la de permitir un control de variables confusoras desde un punto determinista, con un software al alcance de todos los grupos que participan en el proyecto. Además, permite que el método se pueda aplicar de una formar protocolizada y estandarizada que facilite la comparación de resultados y permita la realización de un meta-análisis.

  14. Comportamiento epidemiológico de la rabia paralítica bovina en la región central de México, 2001-2013

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    Isabel Bárcenas-Reyes

    Full Text Available OBJETIVO:Determinar la distribución geoespacial de los casos de rabia paralítica bovina transmitida por Desmodus rotundus en los estados de Guanajuato, Querétaro y San Luis Potosí, México. MÉTODOS: Estudio epidemiológico transversal a partir de los casos notificados por las campañas estatales de control de la rabia paralítica bovina en Guanajuato (2008-2013, Querétaro (2005-2013 y San Luis Potosí (2001-2013. Se confirmaron los casos por inmunofluorescencia directa. Se elaboraron mapas de distribución de los casos por año y por especie, mediante el software ArcMap versión 10.1. Para identificar áreas con condiciones apropiadas para la presencia de casos se combinaron las variables bioclimáticas con los casos georreferenciados, mediante el programa MaxEnt versión 3.3.3. RESULTADOS: Se registraron 1 037 casos, de los cuales, 911 (87,9% ocurrieron en San Luis Potosí, 82 (7,9% en Querétaro y 44 (4,2% en Guanajuato. Del total, 87,4% ocurrió en alturas menores de 1 500 msnm. En Guanajuato y Querétaro, 77,3% y 42,3% de los casos, respectivamente, ocurrieron en alturas mayores de 1 500 msnm. Los meses de mayor incidencia fueron de diciembre a marzo. La variante antigénica viral V11 fue la más frecuente (173 casos, presente en los tres estados estudiados. En el canal endémico, el promedio de casos se mantiene en la zona de seguridad de enero a marzo, pero de abril a junio excede la mediana. La distribución espacial de los casos muestra la diseminación reciente de la enfermedad, lo que coincide con la presencia del murciélago vampiro. CONCLUSIONES: La rabia paralítica bovina se ha extendido a regiones anteriormente libres de esta enfermedad. Las características ambientales y la altura sobre el nivel del mar no limitan la presentación de casos. Se debe mantener un monitoreo constante para la detección oportuna de casos. La vacunación se debe realizar antes del comienzo de las lluvias, sin esperar la aparición de brotes.

  15. Características clínicas y epidemiológicas de la catarata congénita e infantil

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    Merixy Charón Milián

    2012-12-01

    Full Text Available Introducción: la catarata de cualquier etiología es la una de las causas más importantes de ceguera tratable en los niños. Objetivos: caracterizar, desde los puntos de vista clínico y epidemiológico, la catarata congénita e infantil. Métodos: se realizó un estudio observacional, descriptivo y retrospectivo en el Hospital Pediátrico "William Soler", entre enero de 2004 y junio de 2006. Se analizaron las variables: edad, sexo, procedencia, vía de captación, síntomas, factores de riesgo, localización, etiología probable y lateralidad de la catarata, alteraciones oculares asociadas y visión posquirúrgica. Los resultados se expresaron en media y porcentaje. Resultados: la edad promedio fue de 4,9 años y para menores de 1 año de 6,6 meses. Predominaron los varones (60,32 %, los pacientes de La Habana (25,4 %, la remisión médica como vía de captación (71,43 %, la leucocoria (30,15 %, la presencia de anomalías congénitas múltiples (34,92 %, la localización central de la catarata (44,44 %, la causa idiopática (41,27 % y la bilateralidad (66,67 %. El 34,92 % de los pacientes tenía asociada otra anomalía ocular, y el 59,04 % de los ojos operados alcanzaron visión entre 0,7 y 1,0. Conclusiones: en la serie analizada predominaron los lactantes menores de 2 meses y los varones, los pacientes de La Habana, la remisión médica, la leucocoria y las anomalías congénitas múltiples asociadas, la localización central y la posible etiología; en las bilaterales, el origen hereditario; y en las unilaterales, la causa desconocida. La mejoría visual posquirúrgica fue mayor a medida que disminuyó la edad del paciente al momento de realizar la cirugía.

  16. Epidemiologic study of anisometropia in students of Natal, Brazil Estudo epidemiológico da anisometropia em estudantes da cidade de Natal, Brasil

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    Carlos Alexandre de Amorim Garcia

    2005-02-01

    Full Text Available PURPOSE: To perform an epidemiologic study in students in Natal/Brazil, with relation to refractional anisometropia, evaluating criteria such as: gender, age, and association with strabismus and amblyopia. METHODS: A study of 1,024 students randomly selected from several districts of Natal/Brazil was undertaken by the Department of Ophthalmology of the Federal University of Rio Grande do Norte (UFRN, observing the following criteria of > 2 spherical or cylindrical diopter refractional anisometropia relating it to sex, age, association with strabismus, amblyopia and anisometropia classification. RESULTS: We found a prevalence of 2% (N=21 anisometropia in the students. The female gender predominated with 81% (N=17. In students with anisometropia, we observed an association with strabismus in 9.5% of cases (N=2, both with exotropia. The association of anisometropia with amblyopia occurred in 47.6% of the cases (N=10, with 8 cases of unilateral amblyopia and 2 cases of bilateral amblyopia. CONCLUSIONS: There was a predominance of anisometropia in females, and an increased prevalence of strabismus and amblyopia in students with anisometropia.OBJETIVO: Realizar um estudo epidemiológico em estudantes de Natal/Brasil, com relação à anisometropia refracional, avaliando os seguintes critérios: sexo, idade e associação com estrabismo e ambliopia. MÉTODOS: Foram estudados 1.024 estudantes, randomicamente selecionados, pertencentes aos diversos distritos da cidade de Natal/Brasil, pelo Departamento de Oftalmologia, da Universidade Federal do Rio Grande do Norte (UFRN, observando os seguintes aspectos, quanto à anisometropia > 2 dioptrias esférica ou cilíndrica, sexo, idade, associação com estrabismo e ambliopia, e os tipos de anisometropia. RESULTADOS: Encontrou-se prevalência de anisometropia de 2% (N=21 nos estudantes. O sexo feminino predominou com 81% (N=17. Nos estudantes com anisometropia, observou-se associação com estrabismo em 9

  17. Comportamiento clínico epidemiológico de las lesiones bucales en pacientes VIH/SIDA. Artemisa. Enero-Abril 2015

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    Arahí Gómez Casañas

    2016-02-01

    Full Text Available Objetivo: Caracterizar el comportamiento clínico epidemiológico de las lesiones bucales en los pacientes con diagnóstico serológico confirmado de VIH/SIDA, para determinar la prevalencia de lesiones bucales en la población estudiada. Caracterizar la población de estudio según sexo, edad, tiempo de diagnóstico, presencia y tipo de lesiones bucales. Método: Se realizó un estudio observacional, descriptivo, de corte transversal, con los pacientes diagnosticados con VIH/SIDA que acudieron a su consulta de seguimiento del policlínico Tomás Romay, Artemisa en el período de Enero -Abril de 2015, el universo fue de 69 pacientes con diagnóstico confirmado de VIH/SIDA, se tomó una muestra de 25 pacientes que cumplían los criterios de inclusión. Se les realizó un exhaustivo interrogatorio y examen clínico bucal, previo consentimiento informado de los pacientes. Resultados: Del total de pacientes estudiados, el 64% presentó alguna lesión bucal; el 72% de la muestra perteneció al sexo masculino y al grupo de edad de 26 a 35 años; las lesiones bucales predominantes fueron la candidiasis bucal (24.0% seguido del eritema gingival lineal (12.0% ubicándose el mayor número de pacientes con estas lesiones (16%, en el grupo de más de 5 años de diagnóstico. Conclusiones: Se encontró una elevada prevalencia de lesiones bucales en la población objeto de estudio, con predominio del sexo masculino, en el grupo de edad de 26 a 35 años, siendo la candidiasis bucal y el eritema gingival lineal, las dos lesiones más frecuentemente encontradas en la muestra.

  18. Situação epidemiológica da anemia infecciosa equina em equídeos de tração do Distrito Federal

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    Daniella D.A. Moraes

    Full Text Available RESUMO: A anemia infecciosa equina (AIE é uma doença causada por um lentivirus que possui distribuição mundial. Essa enfermidade é um entrave ao desenvolvimento da equinocultura no Brasil devido à obrigatoriedade de eutanásia dos animais positivos. Este trabalho teve como objetivo estimar a prevalência de AIE em equídeos de tração no Distrito Federal, assim como identificar fatores de risco associados à doença. Foram sorteados aleatoriamente 350 proprietários (Unidades Primárias de Amostragem- UPA e foram amostrados todos os equídeos (Unidades secundárias de Amostragem de cada proprietário sorteado, totalizando 496 animais. As amostras sanguíneas foram analisadas no Lanagro/MG por meio da técnica de imunodifusão em ágar gel (IDGA. No momento da coleta de sangue, também foi aplicado um questionário epidemiológico para a análise de possíveis fatores de risco. A prevalência de AIE nas UPA foi estimada em 2,29%, (IC 95%: 1,01-4,2% e nos animais foi de 1,81% (IC 95%: 0,55-3,07%. A prevalência foi significativamente maior em muares do que em equinos. Não foi possível comprovar a presença de nenhum outro fator de risco associado à doença. Este estudo demonstra que a prevalência da AIE em equídeos de tração é baixa no Distrito Federal, porém mais alta do que os dados de vigilância de rotina sugerem, o que justifica a eutanásia dos equídeos reagentes, com a finalidade de promover a erradicação da enfermidade. Ratifica-se a importância da realização de exames periódicos nesses animais e a manutenção das atividades de vigilância.

  19. Tuberculosis en pacientes con diabetes mellitus: Un estudio epidemiológico y clínico en el Hospital Nacional Cayetano Heredia

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    Juan Luis DELGADO ROSPIGLIOSI

    2006-07-01

    Full Text Available Objetivo: Describir las características epidemiológicas y clínicas de pacientes diabéticos con tuberculosis atendidos en el Hospital Nacional Cayetano Heredia (HNCH. Material y Métodos: Estudio retrospectivo, observacional, descriptivo. Se identificaron los "casos" (pacientes diabéticos con TBC revisando los registros del Servicio de Endocrinología, Servicios de hospitalización de Medicina y del Departamento de Enfermedades Infecciosas y Tropicales del HNCH atendidos durante el periodo de 1997 al 2003. Resultados: Se encontraron 85 episodios de TBC en 74 historias clínicas revisadas. El promedio de edad fue de 49,4 +12,8 años; 48/74 (65% fueron hombres y 26/74 (35% mujeres. 72/74 (97,3% pacientes presentaron diabetes mellitus tipo 2. El tiempo promedio de enfermedad diabética previo al desarrollo de TBC fue de 4.2 +4 años. 75/85 (88,2% episodios presentaron TBC pulmonar, habiendo confirmación bacteriológica en el 51,3% de estos casos. 59/85 (69% casos no cumplían regularmente con el tratamiento indicado para la diabetes y 60/85 (71% tenían mal control metabólico al desarrollar TBC. 31/74 (42% pacientes fueron hospitalizados por TBC, asociándose cetoacidosis diabética (CAD en el 51,4% de las hospitalizaciones por esta causa. La TBC puede ser causa importante desencadenante de CAD en nuestro medio. La tasa de fracasos al tratamiento fue de 15/85 (17,6%; hubo sospecha de TB-MDR en 13/74 pacientes (17,6%. La tasa de recaídas fue de 15/74 (20,3%. Fallecieron 3/74 pacientes (4% durante el período de estudio. Conclusiones: Pacientes diabéticos mal controlados desarrollan TBC con una elevada tasa de recaídas, fracasos y TB-MDR, con alta sospecha de contagio intrahospitalario. (Rev Med Hered 2006;17:132-140.

  20. El abordaje epidemiológico de las desigualdades en salud a nivel local The epidemiological approach to health inequalities at the local level

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    Marcio Alazraqui

    2007-02-01

    Full Text Available Para responder la pregunta ¿cuáles son los usos y limitaciones de la epidemiología en la reducción de las desigualdades en el nivel local? se problematiza el "papel" de la epidemiología. La hipótesis es que la epidemiología produce conocimiento útil a la gestión en el nivel local para el desarrollo de intervenciones dirigidas a la reducción de desigualdades en salud. Estas desigualdades se expresan en un espacio construido por colectivos humanos en procesos sociales e históricos. La producción de conocimiento epidemiológico en el nivel local debe estar orientada a dar soporte a las acciones de un actor social en situación y en un determinado escenario. Por eso se revalorizan los estudios ecológicos y la georreferencia. Esta producción y aplicación de conocimiento es también un fenómeno organizacional. Se entienden las organizaciones como "redes de conversaciones". Se concluye que las acciones estratégicas y las acciones comunicativas de los trabajadores de salud deben constituirse como eje central en la definición de nuevos modelos de cuidado y de gestión comprometidos con la reducción de desigualdades en salud, donde la epidemiología cumple un rol relevante.What are the advantages and limitations of epidemiology for decreasing health inequalities at the local level? To answer this question, the current article discusses the role of epidemiology. The hypothesis is that epidemiology produces useful knowledge for local management of interventions aimed at reducing health inequalities, expressed in spaces built by human communities through social and historical processes. Local production of epidemiological knowledge should support action by social actors in specific situations and contexts, thus renewing the appreciation for ecological designs and georeference studies. Such knowledge output and application are also an organizational phenomenon. Organizations can be seen as "conversational networks". In conclusion, strategic

  1. Aspectos epidemiológicos sobre mordeduras caninas durante el año 2011 en la ciudad de Temuco, Chile.

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    Waldo Armstrong,

    2016-03-01

    Full Text Available Los accidentes causados por mordeduras de perros y gatos son un problema de salud pública y concretamente las mordeduras de perro constituyen el riesgo más grave que estos animales suponen para la salud de las personas. A los costes económicos derivados del tratamiento de las lesiones físicas debemos añadir las secuelas psicológicas que muchas veces aparecen tras las agresiones. La prevención es el único camino para resolver este problema y puede efectuarse mejor cuando se conocen los diversos factores involucrados en la génesis de este tipo de accidentedebido a lo anterior el objetivo del estudio fue describir las características epidemiológicas asociadas a las personas mordidas por perros. La metodología utilizada para la recolección de datos fue la aplicación de una encuesta a 9 centros asistenciales de la ciudad de Temuco. Se solicitó información sobre pacientes atendidos por mordeduras caninas durante el año 2011 y los datos recolectados se ingresaron en una planilla de cálculos. Los resultados indican que niños y adultos presentan 52% de las mordeduras durante el año. Los hombres presentan una mayor incidencia con un 47% a diferencia de las mujeres con un 44%. Con respecto a la región corporal afectada los miembros superiores alcanzan un 25% de frecuencia ante el ataque y los miembros inferiores un 31.3%. Por otra parte, las mordeduras por perros presentaron una marcada estacionalidad en los meses de verano con un 30% de casos. Se concluye que las mordeduras caninas son un problema frecuente y de real importancia en el ámbito de salud pública, generando en la población secuelas físicas y psicológicas por las lesiones generadas durante el ataque.

  2. Perfil clínico-epidemiológico dos pacientes internados na clínica pediátrica em um hospital universitário

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    José Sávio Menezes Parente

    2017-04-01

    Full Text Available Introdução: a infância é um período de grande importância na formação do ser humano, logo, um episódio de doença pode interromper esse processo, além de interferir na estrutura familiar e gerar ônus ao sistema de saúde. A epidemiologia e a morbidade atuam como importantes instrumentos, pois promovem o conhecimento em saúde e auxiliam na distribuição dos recursos, alcançando os vários níveis administrativos. Porém, estudos que envolvem o perfil de internações pediátricas ainda são escassos. O estudo tem como objetivo delinear perfil epidemiológico e clínico dos pacientes internados na enfermaria de pediatria. Metodologia: estudo realizado na enfermaria de pediatria do Hospital Universitário Walter Cantídio (HUWC com amostra de 119 registros, referentes aos meses de agosto a dezembro de 2015. Resultados: a idade média é de 8,6 anos, sendo que no sexo feminino houve predomínio na faixa da adolescência. Os 3 sistemas mais acometidos foram: sistema digestivo, sistema endócrino e sistema respiratório. A permanência hospitalar média foi de 10,09 dias. Condições crônicas foram encontradas em 48,1% dos registros, sendo o Diabetes Mellitus a mais comum. 25,2% dos casos possuíam internamentos prévios, em sua grande maioria portadores de patologias crônicas. A grande maioria das altas ocorreram para domicílio. Discussão e Conclusão: o estudo demonstra particularidades da enfermaria de pediatria do HUWC, sendo possível guiar o ensino de residentes e estudantes, além de auxiliar na formação de políticas, melhoria do atendimento e preparo da equipe ligada aos cuidados com o paciente.

  3. Síndrome de burnout e fatores associados: um estudo epidemiológico com professores Factors associated with burnout's syndrome: an epidemiological study of teachers

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    Mary Sandra Carlotto

    2006-05-01

    Full Text Available O estudo apresenta os resultados obtidos em uma investigação sobre a síndrome de burnout em professores de escolas particulares de uma cidade da região metropolitana de Porto Alegre, Rio Grande do Sul, Brasil. Trata-se de um estudo epidemiológico que buscou identificar o nível da síndrome de burnout, verificando possíveis associações com variáveis demográficas, laborais e fatores de estresse percebidos no trabalho. A população do estudo estava composta por 217 professores, dos quais, participaram 190 sujeitos (87,5%. Como instrumento de pesquisa, utilizou-se o MBI para medir burnout, associado a um questionário para o levantamento das demais variáveis. Os resultados obtidos revelaram que professores apresentam nível baixo nas três dimensões que compõem burnout: exaustão emocional, despersonalização e diminuição da realização pessoal no trabalho. Variáveis demográficas não apresentaram relação com as dimensões de burnout, sendo que, das variáveis profissionais, a carga horária e a quantidade de alunos atendidos foram as que mostraram associação com a dimensão de exaustão emocional. Mau comportamento dos alunos, expectativas familiares e pouca participação nas decisões institucionais foram os fatores de estresse que apresentaram associação com as dimensões de burnout.This article presents the results of an epidemiological study on burnout syndrome among private school teachers in Greater Metropolitan Porto Alegre, Rio Grande do Sul, Brazil, testing possible associations with demographic, work-related, and stress-related variables. The target population consisted of 217 teachers, of whom 190 participated (87.5%. The Maslach Burnout Inventory (MBI was used to measure burnout, together with a questionnaire to record the other variables. The results showed that teachers have a low score in the three dimensions comprising burnout: emotional exhaustion, depersonalization, and decreased personal fulfillment at

  4. La financiación de la industria alimentaria y la investigación epidemiológica sobre nutrición y salud

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    Eva María Navarrete-Muñoz

    2018-03-01

    Full Text Available El interés de la industria alimentaria por financiar investigaciones en temas de nutrición y salud no se limita solo al avance científico. Algunas revisiones sistemáticas han puesto de manifiesto un sesgo en las conclusiones de los estudios que habían recibido financiación de la industria alimentaria, particularmente cuando comunicaban los efectos de las bebidas azucaradas. En este contexto, coincidiendo con la XXXIV Reunión Científica de la Sociedad Española de Epidemiología, el Grupo de Nutrición de esta sociedad organizó una mesa temática titulada Industria alimentaria e investigación epidemiológica para abordar el tema de la conveniencia o no de que la industria alimentaria financie directamente proyectos de investigación, y los posibles conflictos de intereses que pueden derivarse de esta financiación. Todos/as los/las participantes coincidieron en la necesidad de garantizar el rigor y la calidad necesarios en los estudios, y su realización de forma independiente de la financiación recibida, para evitar sesgos que lleven a una pérdida de credibilidad de los resultados de las investigaciones por los posibles conflictos de intereses. El Dr. Pérez-Farinós y la Dra. Romaguera coincidieron en que una forma de evitar conflictos de intereses era impedir que la industria financiara proyectos de investigación; la Dra. Marcos y el Prof. Martínez-González indicaron la conveniencia de establecer mecanismos para evitar que la financiación de la industria influya tanto en la distribución de fondos entre grupos e instituciones como en el análisis y los resultados de las investigaciones, para garantizar al máximo la independencia de los investigadores, así como su ética profesional.

  5. Actinic keratosis: a clinical and epidemiological revision Queratoses actínicas: revisão clínica e epidemiológica

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    Juliano Vilaverde Schmitt

    2012-06-01

    Full Text Available Actinic keratoses are benign intraepithelial skin neoplasms constituted by atypical proliferation of keratinocytes that may evolve to squamous cell carcinoma. They develop in photoexposed skin areas; they are induced mainly by ultraviolet radiation and are considered cutaneous markers of chronic exposure to sunlight. They develop mainly in adults and older, fair skinned individuals, and are the fourth most common cause of dermatologic consultation in Brazil. Damage to the apoptosis pathway in photoexposed epithelium favors cellular proliferation and the permanence of the lesions. In this revision, the authors assemble the main epidemiological data regarding this disease and suggest that strategies to identify risky phenotypes, early diagnosis, adequate treatment, clinical follow-up, stimulus to skin self examination, photoeducation and photoprotection should be promoted with the aim of avoiding the progression to malignancy and also the prevention and the diagnose of concomitant neoplasms also induced by ultraviolet radiation.Queratoses actínicas são neoplasias benignas intraepiteliais formadas por proliferações atípicas de queratinócitos com potencial de transformação em carcinoma espinocelular. Desenvolvem-se em áreas fotoexpostas da pele, são induzidas principalmente pela radiação ultravioleta e constituem marcadores de exposição solar crônica. Acometem indivíduos adultos e idosos, de fototipos claros, representando o quarto diagnóstico dermatológico mais comum no Brasil. Danos nas vias de apoptose do epitélio fotoexposto favorecem a proliferação celular e manutenção das lesões. Nesta revisão os autores reúnem os principais dados epidemiológicos sobre a doença e defendem que estratégias de identificação de fenótipos de risco, diagnóstico precoce, tratamento adequado, seguimento clínico, incentivo ao autoexame da pele, fotoeducação e fotoproteção devem ser promovidas, a fim de evitar a evolução das les

  6. Adicción a internet: Perfil clínico y epidemiológico de pacientes hospitalizados en un instituto nacional de salud mental

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    Lizardo CRUZADO DÍAZ

    2006-10-01

    Full Text Available Objetivo: Conocer las características clínicas y epidemiológicas de los pacientes hospitalizados con diagnóstico de "adicción a internet" en el Instituto Nacional de Salud Mental Honorio Delgado - Hideyo Noguchi desde la apertura del servicio de hospitalización el año 2001 hasta febrero del 2006. Material y Métodos: Estudio descriptivo, retrospectivo y trasversal: se revisaron las historias clínicas de 30 pacientes con el diagnóstico de "adicción a internet" y se les sometió a una breve encuesta durante sus controles por consultorio. Resultados: La edad promedio fue 18,3 ±3,8 años. Los rasgos de personalidad más frecuentes fueron los antisociales (40%. Tres pacientes sufrieron tuberculosis pulmonar durante su adicción. Hubo historia de disfunción familiar en 80% de los pacientes y 56,7% tuvo antecedentes psiquiátricos familiares. El 83,3% de pacientes inició el uso de internet cuando menos dos años antes del ingreso y el 50% se conectaba más de 6 horas diarias. El 90 % de pacientes se abocaba prioritariamente a los juegos en red. Los síntomas principales fueron irritabilidad (80% y merma de rendimiento académico (76,7%. La mayor comorbilidad se halló con trastornos afectivos (56,7%. Seis (2% presentaron ideación o intento suicida. Trece (43,3% tuvieron antecedente de uso excesivo de videojuegos. Conclusiones: Nuestros pacientes con adicción a Internet se caracterizan por su corta edad, elevado tiempo de uso diario de internet, predominancia de uso de juegos en red y marcada frecuencia de conductas psicopáticas. Su adicción redundó en importante deterioro personal, académico y de relaciones familiares. Se requieren estudios prospectivos para precisar mejor las características de esta patología emergente.(Rev Med Hered 2006;17:196-205.

  7. Panorama epidemiológico de la mortalidad por cáncer en el Instituto Mexicano del Seguro Social: 1991-1995

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    SALMERÓN-CASTRO JORGE

    1997-01-01

    Full Text Available Objetivo. Describir el comportamiento de la mortalidad global por cáncer, así como la mortalidad específica para las principales neoplasias malignas en población adulta derechohabiente (DH del Instituto Mexicano del Seguro Social (IMSS. Material y métodos. A partir de los registros oficiales de defunción y de la información sobre la población para los años 1991-1995, se estimaron las tasas anuales de mortalidad global y específica para las 10 principales neoplasias malignas por sexo, en mayores de 20 años. Asimismo, se estimaron las tendencias nacionales y estatales para las principales neoplasias malignas para cada sexo por medio de regresión de Poisson. Se calcularon las diferencias de tasas de mortalidad específica para las dos principales neoplasias por sexo restando las tasas estatales a su respectiva tasa nacional en 1995. Resultados. La mortalidad global por cáncer en los hombres se incrementó de 76.2 en 1991, a 94.8 por 100 000 DH en 1995; entre las mujeres, ésta se incrementó de 85.6 a 105.8 por 100 000 DH, representando un incremento de 24.4 y de 24% en hombres y mujeres, respectivamente, durante el periodo de estudio. Entre los hombres las neoplasias de riñón, leucemia, páncreas, próstata y pulmón; y entre mujeres las de colon, mama, páncreas, leucemias e hígado, mostraron los incrementos más significativos. Conclusiones. En el IMSS es impostergable la conformación de un registro poblacional de cáncer que permita una mejor vigilancia epidemiológica de las neoplasias y una evaluación permanente del impacto de programas específicos para la prevención y control de este padecimiento en las instituciones.

  8. Características clínico epidemiológicas de pacientes con infarto miocárdico agudo

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    Omar Lóriga García

    2013-12-01

    Full Text Available Introducción: la cardiopatía isquémica, y entre estas el Infarto Agudo del Miocardio con elevación del segmento ST, es la primera causa de muerte a nivel mundial. Objetivo: describir las características clínico epidemiológicas de pacientes con infarto agudo del miocardio de la unidad de cuidados coronarios del Hospital General Docente Abel Santamaría Cuadrado de Pinar del Río, en 2011 y 2012. Material y Método: estudio observacional, descriptivo, retrospectivo transversal; universo 644 pacientes ingresados con elevación del ST. Los datos se tomaron de las historias clínicas. Resultados: 62% tenían entre 60- 79 años. 84.5% de los pacientes entre 30 y 49 años eran hombres. 81,6% fumaba y el 45,5% era diabético. La localización topográfica del infarto fue: inferior el 70,8%, anterior el 22,9% y anterior extensa el 6,2% de los pacientes. Como complicación, la arritmia se presentó en el 34% de los pacientes, la insuficiencia cardiaca en el 14,9% y la muerte en 7,7%. El 68,5% de los pacientes con arritmias tuvo fibrilación auricular. La trombolisis se empleó en el 55,2% de los pacientes apareciendo, entre las complicaciones, la hipotensión en el 30,7%. Conclusiones: el infarto miocárdico agudo fue más frecuente en pacientes de mayor edad, siendo antes de los 50 años cinco veces más frecuente entre los hombres. Los factores de riesgo más representados fueron el hábito de fumar y la diabetes mellitus. La localización más frecuente fue la inferior y la complicación las arritmias y dentro de estas la fibrilación auricular. La trombolisis se complica principalmente con hipotensión, pudiendo ser más empleada.

  9. Achados epidemiológicos e alterações oftalmológicas em diabéticos atendidos em hospital geral secundário

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    Mariluce Silveira Vergara

    2014-06-01

    Full Text Available Objetivo: Avaliar a associação entre alterações no exame oftalmológico, características epidemiológicas e controle metabólico em pacientes diabéticos. Métodos: Estudo transversal. Foram selecionados consecutivamante os diabéticos atendidos durante 2011 em um hospital secundário. Todos os pacientes responderam questionário e foram submetidos a exame oftalmológico. Resultados: Foram estudados 103 pacientes, dos quais 72 (69,9% eram do sexo feminino e 66 (64% da cor branca. A média de idade foi de 59 (+/- 9,21 anos. Sessenta e quatro por cento dos participantes referiram renda aproximada de até 1 salário mínimo, 58,2% tinham ensino fundamental incompleto, 75,7% com história de diabetes familiar, 45,6% informaram realizar controle metabólico regular, 54,3% não observavam cuidados nutricionais, 28% usavam insulina, 99% eram diabéticos do tipo-2. Ao exame, 72,8% apresentaram acuidade visual corrigida de 20/40. Foram estatisticamente significativas as relações entre complicações retinianas e o uso de insulina (OR=8,3; p=0,003 e da baixa acuidade visual com o uso de insulina (OR=5,48, p=0,021 e a idade (OR=11,8; p=0,003. Também foi observada relação entre a baixa de visão com escolaridade, idade e baixa renda Conclusão: Na população analisada, predominantemente de baixa renda e escolaridade, a condução inadequada da doença foi expressiva, o que se associou com a presença de complicações retinianas, reforçando a necessidade de adoção de medidas mais amplas para melhorar as estratégias de controle e prevenção do diabete mellitus.

  10. Rinite alérgica: aspectos epidemiológicos, diagnósticos e terapêuticos Allergic Rhinitis: epidemiological aspects, diagnosis and treatment

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    Cássio da Cunha Ibiapina

    2008-04-01

    Full Text Available Este estudo tem como objetivo revisar a literatura a respeito da rinite alérgica quanto aos aspectos epidemiológicos, clínicos, diagnósticos e terapêuticos. A revisão da bibliografia foi realizada utilizando-se as bases de dados Medline, Literatura Latino-Americana e do Caribe em Ciências da Saúde e HighWire, nos últimos trinta anos, utilizando-se os descritores allergic rhinitis, epidemiology, diagnosis, e treatment. Foram selecionados 60 artigos. Este estudo destaca o aumento na prevalência da rinite alérgica, sua associação com a asma, os critérios diagnósticos e seu tratamento. A classificação da rinite alérgica é apresentada, bem como as estratégias de tratamento. As modalidades terapêuticas apresentadas e discutidas são anti-histamínicos, corticóides, imunoterapia, antileucotrienos, cromoglicato dissódico e anticorpos anti-IgE, bem como a redução da exposição aos alérgenos. Finalmente, ressalta-se a importância da abordagem da rinite alérgica em saúde pública.This study was a review of the literature on the epidemiological, clinical, diagnostic and therapeutic aspects of allergic rhinitis. Bibliographic searches were based on the information contained within the Medline, Latin American and Caribbean Health Sciences Literature and HighWire databases, covering the last thirty years and using the following search terms: 'allergic rhinitis', 'epidemiology', 'diagnosis' and 'treatment'. Sixty articles were selected. This study describes the increase in the prevalence of allergic rhinitis, its relationship with asthma, the diagnostic criteria and the treatment. The classification of allergic rhinitis and strategies for its treatment are presented. Therapeutic modalities presented and discussed include the administration of antihistamines, corticosteroids, immunotherapy, anti-leukotrienes, sodium cromoglycate and anti-IgE antibodies, as well as minimizing exposure to inhaled allergens. Finally, the importance of

  11. Algunas características clínico-epidemiológicas de los casos de tuberculosis hospitalizados en el instituto "Pedro Kourí"

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    Gilberto Moya Jústiz

    1999-01-01

    Full Text Available Aunque las cifras de tuberculosis en Cuba se mantienen entre las más bajas de América y Europa, su tendencia descendente se invirtió a partir de 1992, y tuvieron lugar brotes de pequeña magnitud, principalmente en pacientes VIH. Con el propósito de evaluar algunos indicadores clínico-epidemiológicos revisamos 86 Historias clínicas de pacientes notificados como tuberculosos por el hospital del IPK durante el período 1994-95. Finalmente se evaluaron los 68 que fueron egresados con este diagnóstico. Para el análisis estadístico se utilizaron los programas EpiInfo-6 y Microsta. El mayor número de casos ocurrió en el 1er trimestre de 1994. Predominaron las edades jóvenes (m = 32 años y el sexo masculino (67,6 %, así como los casos nuevos (91,1 % y la forma clínica pulmonar (91,2 %. Predominó el diagnóstico clínico-radiológico (54,4 %, y por examen directo se pudieron diagnosticar 2 de cada 3 pacientes con TB pulmonar. El 50 % de los casos VIH cursó sin manifestaciones radiológicas.Although the figures of tuberculosis in Cuba are among the lowest in America and Europe, its decreasing trend changed from 1992 on and there have been outbreaks of small magnitude, mainly in HIV patients. 86 medical histories of tuberculous patients reported by the hospital of the Institute of Tropical Medicine from 1994 to 1 995 were reviewed aimed at evaluating some clinical and epidemiological indicators. Finally, 68 that were discharged whit this diagnosis were evaluated. The EpiInfo-6 and Microsta programs were used in the statistical analysis. The highest number of cases was observed in the first trimester of 1994. Young ages (m = 32 years old and males (67,6 % predominated, as well as the new cases (91 % and the clinical pulmonary form (91,2 %. The clinical and radiological examination prevailed (54,4 %. 2 out of 3 patients with pulmonary tuberculosis were diagnosed by direct examination. 50 % of the HIV cases had no radiological

  12. Caracterización clínico-epidemiológica de la otitis media aguda en pacientes pediátricos

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    Ileana Álvarez Lam

    2011-09-01

    Full Text Available Introducción: la otitis media aguda es una de las enfermedades infecciosas más frecuentes en la infancia, y constituye una de las causas más importantes de consultas médicas y prescripción de antibióticos en los menores de 5 años. Objetivo: determinar el comportamiento clínico epidemiológico de la enfermedad. Métodos: se realizó un estudio descriptivo, longitudinal prospectivo con 60 pacientes entre 1 mes y 14 años de edad con diagnóstico de otitis media aguda purulenta en el Hospital Pediátrico Docente "William Soler", durante el período de 1 año (enero a diciembre de 2008. Los datos clínicos se obtuvieron mediante una encuesta a los padres o tutores de los pacientes. A todos se les realizó timpanocentesis con cultivo y exudado nasofaríngeo. Las cepas aisladas fueron enviadas al Laboratorio Nacional de Referencia de S. pneumoniae y H. influenzae del Instituto de Medicina Tropical "Pedro Kourí" para la caracterización microbiológica y determinación de susceptibilidad antimicrobiana. Resultados: la enfermedad predominó en el grupo ubicado entre 12 y 23 meses (55 %, con mayor afectación del sexo masculino (52 %. La fiebre y las manifestaciones locales referidas a oído medio (irritabilidad, otalgia, llanto nocturno fueron los elementos clínicos referidos con mayor frecuencia. El cuidado fuera del hogar, la exposición al humo de tabaco y el destete precoz fueron los factores de riesgo más frecuentes. S. pneumoniae, H. influenzae no tipificable y S. epidermidis fueron los gérmenes aislados con mayor frecuencia. El 25 % de las cepas de S. pneumoniae tuvieron resistencia intermedia a la penicilina, pero no se reportó resistencia a cefalosporinas de tercera generación. El 98,4 % de los pacientes evolucionaron satisfactoriamente. Las complicaciones de la enfermedad se presentaron en 1,6 % de los casos. Conclusiones: la otitis media aguda es frecuente en niños menores de 36 meses, y está muy relacionada con la presencia

  13. Situação epidemiológica dos acidentes de trabalho na unidade regional de emergência de Sorocaba

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    Dorival Manrique Duarte Junior

    2014-10-01

    Full Text Available Introdução: Apesar do avanço no Sistema de Informação de Agravos de Notificação (SINAN ainda há extensa subnotificação dos acidentes de trabalho no Brasil. Dentre os acidentes notificados, verifica­se falta de dados nas informações obtidas. Objetivo: Analisar o perfil epidemiológico dos acidentes de trabalho atendidos na Unidade Regional de Emergência (URE do Conjunto Hospitalar de Sorocaba (CHS. Metodologia: Estudo transversal com análise quantitativa e qualitativa dos acidentes de trabalho recebidos na URE do CHS através da Ficha de Notificação de Acidente de Trabalho Grave do SINAN. Realizada análise descritiva das variáveis categóricas e contínuas. Resultados: Foram analisadas 110 vítimas, cujas características predominantes eram: sexo masculino (77,27%, idade entre 20 e 39 anos (38,18% e presença de registro trabalhista (65,45%. As duas principais causas foram acidente com motocicleta (46,4% e queda (21,8%. Ademais, 57,3% dos acidentes foram classificados como de trajeto, de maior incidência nos períodos da noite e madrugada, e 41,2% típico, mais freqüente nos períodos da manhã e tarde (p=0,012. Da totalidade dos casos, 38,3% evoluíram para cura e 58,8% para incapacidade temporária. Conclusão: O acidente de trabalho é importante problema de saúde pública e gera grande impacto econômico por acometer principalmente indivíduos jovens e saudáveis. É muitas vezes negligenciado em decorrência da subnotificação e consequente subdimensionamento da sua gravidade, prejudicando o subsídio de políticas de saúde direcionadas a esses agravos.

  14. Síndrome climatérico: caracterización clínica y socio-epidemiológica Climacteric syndrome: clinical and socioepidemiological characterization

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    Margeris Yanes Calderón

    2004-08-01

    Full Text Available Se realizó un estudio descriptivo y transversal a 80 mujeres climatéricas, en el período comprendido entre septiembre del año 2003 y junio de 2004, con el objetivo de conocer las características clínicas y socio-epidemiológicas que tienen mayor incidencia, así como analizar la repercusión biopsicosocial del climaterio en las mujeres del consultorio 1.1 de La Puntilla, en el Policlínico Docente "Ana Betancourt", del municipio Playa, en la Ciudad de La Habana. En las pacientes estudiadas prevaleció el síndrome climatérico leve, y las enfermedades crónicas más frecuentes fueron la hipertensión arterial y la artrosis. Más del 50 % de las mujeres encuestadas se desenvuelven en un medio familiar funcional, y el 75 % refiere una buena satisfacción de sus necesidades básicas, en correspondencia con un entorno higiénico habitacional bueno, lo que guarda una estrecha relación con el nivel sociocultural y económico del area de salud investigada.A descriptive and cross-sectional study was carried out in 80 climacteric women from September 2003 to June 2004 aimed at knowing the clinical and socioepidemiological characteristics with the highest incidence, and at analyzing the biopsychosocial repercussion of the climacteric in women from the family phsycian's office 1.1, in La Puntilla, at "Ana Betancourt" Teaching Polyclinic, "Playa" municipality, Havana City. The mild climacteric syndrome prevailed in the studied patients. The most frequent chronic diseases were arterial hypertension and arthrosis. More than 50 % of the surveyed women belonged to a functional family environment, and 75. 5 % referred to a good satisfaction of their basic needs in correspondance with a good hygienic housing setting that is closely related to the sociocultural and economic level of the investigated health area.

  15. Perfil epidemiológico e genotípico da infecção pelo vírus da hepatite B no Norte de Portugal

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    Ana Mota

    2010-12-01

    Full Text Available OBJECTIVO: Descrever o perfil epidemiológico e genotípico da infecção crônica pelo vírus da hepatite B na Região Norte de Portugal. MÉTODOS: Foram incluídos 358 indivíduos oriundos das consultas de especialidade que apresentavam resultados positivos para o antígeno da hepatite B durante pelo menos seis meses em dois hospitais do Norte de Portugal em 2008 e 2009. Os dados foram obtidos a partir dos processos clínicos, determinações laboratoriais feitas quando da genotipagem do vírus, ecografia e/ou ultra-sonografia e biópsia hepática. As características demográficas, marcadores víricos, carga viral e genótipos, e severidade da doença hepática foram avaliadas e comparadas entre sexos. RESULTADOS: Os genótipos A e D predominaram. A transmissão intrafamiliar ocorreu predominantemente nas mulheres. Um terço das mulheres apresentava ingestão alcoólica superior a 20 g/dia, aumentando para 58,9% nos homens. A ausência do AgHBe foi semelhante nos dois sexos (p = 0,662. Os parâmetros bioquímicos em geral apresentaram-se com valores mais altos nos homens, assim como nos estágios necro-inflamatório e de esteatose hepática (p = 0,003. CONCLUSÕES: As diferenças relativas às vias de transmissão da infecção pelo vírus da hepatite B entre homens e mulheres podem ser conseqüência de comportamentos de risco associadas ao género. A ingestão excessiva de álcool é predominante nos indivíduos do sexo masculino, assim como maior severidade da doença hepática em relação às mulheres.

  16. Perfil epidemiológico e nível de conhecimento de pacientes diabéticos sobre diabetes e retinopatia diabética

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    Alana Ferreira Gomes Dias

    2010-10-01

    Full Text Available OBJETIVO: Conhecer o perfil epidemiológico e nível de conhecimento de pacientes diabéticos sobre diabetes e retinopatia diabética (RD. MÉTODOS: Estudo transversal com pacientes atendidos no Ambulatório de Retina e Vítreo do Hospital do Servidor Público Estadual de São Paulo, os quais foram divididos em dois grupos: pacientes diabéticos encaminhados para primeira avaliação oftalmológica (G1 e pacientes já acompanhados no Ambulatório (G2. Os pacientes responderam questionário e submeteram-se a exame oftalmológico. Foram utilizados os testes x², exato de Fisher e não paramétricos de Mann-Whitney, presumindo nível de significância de 5%. RESULTADOS: A amostra total foi composta por 357 pacientes (109 no G1 e 248 no G2. A maioria dos pacientes era do sexo feminino, casada, com ensino fundamental incompleto, com média de idade de 63,3 anos e afirmou saber o que é diabetes. Entretanto, 53,2% não sabiam qual o seu tipo de diabetes. As complicações visuais do diabetes são as mais conhecidas. Menos de um terço dos pacientes já tinha ouvido falar em RD e 77,3% não sabiam se eram acometidos. A maioria dos pacientes nunca havia recebido alguma explicação ou algum tipo de material escrito sobre diabetes ou RD. Somente 3,6% dos pacientes participavam de algum programa de educação sobre diabetes. A AV média na amostra, em logMAR, foi de 0,57 no OD e 0,51 no OE. Metade dos pacientes não tinha RD. CONCLUSÃO: A maioria dos pacientes, apesar de receber acompanhamento multidisciplinar, apresentou pouco conhecimento sobre o diabetes e suas complicações.

  17. Leishmaniose visceral canina: avaliação da metodologia sorológica utilizada em inquéritos epidemiológicos

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    Carlos A. da Costa

    1991-03-01

    Full Text Available Foi realizado um estudo comparativo da reação de imunofluorescência indireta em eluatos de sangue de cães infectados experimentalmente com diferentes tripanosomatídeos. Utilizaram-se como antigenopromastigotas de L. mexicana, L. braziliensis e L. chagasi. Os resultados mostraram que a sensibilidade do método foi de 87,5% para o diagnóstico do calazar canino, independentemente do antigeno empregado; e que ocorre reação cruzada com Leishmaniose tegumentar em 75% dos casos e com doença de Chagas em 83,3%. Levantamento epidemiológico em área de leishmaniose confirma que a reação de imunofluorescência em eluatos de sangue canino fornece reações cruzadas em cães infectados com Leishmania braziliensis e L. chagasi. Não se verificou reação cruzada pela RFC. Sugere-se a utilização da reação de imunofluorescência nas campanhas de saúde pública, mas é de se chamar a atenção para o fato de que as taxas de positividade não devem ser utilizadas como indicadores da prevalência do calazar canino.A comparative study was made of eluates of the blood of dogs experimentally infected with different trypanosomatids. Using antigens prepared from promastigotes of Leishmania mexicana, L. braziliensis and L. chagasi, assessments were made by the indirect immunofluorescence test. The results showed a sensitivity of 87,5% in the diagnosis of canine visceral leishmaniasis, independent of antigen used. Cross-reactions occurred in 75% of cases of cutaneous leishmaniasis and 83,3% of dogs with chagas' disease. An epidemiological survey in an area of leishmaniasis confirmed that immunofluorescence tests on eluates of dogs' blood give cross-reactions between L. braziliensis and L. chagasi. The results suggest that such testing could be useful in public health campaigns but attention is drawn to thefact that the level ofpositive reactions cannot be used as an indicator of the prevalence of canine kala-azar.

  18. Valoración epidemiológica de la linfadenitis tuberculosa en un distrito de Barcelona: propuesta de algoritmo diagnóstico

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    Silvia Aguilar-Duran

    2014-01-01

    Full Text Available Fundamentos: Barcelona ha experimentado un cambio en su demografía que ha afectado la epidemiología local de la linfadenitis tuberculosa (LT. El objetivo del estudio es conocer los factores actualmente asociados a LT en un distrito de Barcelona con una incidencia media de TB superior a 50 casos por 10.000 habitantes/año así como plantear un algoritmo diagnóstico. Métodos: estudio de cohortes retrospectivo de todos los casos de LT diagnosticados entre 1990 y 2009 en el Hospital del Mar de Barcelona. De acuerdo a los cambios demográficos, se establecieron dos periodos de estudio (1990-1999 y 2000-2009 y se analizaron y compararon las características sociodemográficas, clínicas y diagnósticas de los sujetos con LT para la posterior realización del algoritmo. La información se obtuvo de las encuestas epidemiológicas realizadas a los pacientes diagnosticados de LT en el Hospital del Mar y notificadas a la Agència de Salut Pública de Barcelona. Resultados: en el primer periodo, 152 pacientes presentaron LT (siendo 73,7% autóctonos y en el segundo 147 (siendo 70,7% inmigrantes. En el primer periodo, el porcentaje de hombres immigrantes fue del 70,5% y 57,1% menores de 35 años, aunque en el segundo periodo se observó en autóctonos e l 58,1% de mujeres y 69,8% mayores de 35 años. El porcentaje de pacientes autóctonos con VIH disminuyó de 66,9% a 44,2% en el segundo periodo y hubo aumento de pacientes en tratamiento inmunosupresor (9,3%. El análisis multivariante dio como resultado (OR 8,2;IC 95% 3,4-19,8 para el uso de drogas intravenosas y OR 4,8 (IC95% 2,7-8,3para la inmigración como factores de riesgo a LT. Conclusiones: los varones inmigrantes menores de 35 años procedentes de zonas endémicas de tuberculosis y los autóctonos mayores de 35 años con VIH (aunque con un menor porcentaje de coinfección que antes del año 2000 o en tratamiento inmunosupresor son los grupos con más riesgo de presentar LT en nuestro distrito.

  19. La ventaja epidemiológica de la orientación preferencial del control de la tuberculosis hacia los pobres

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    J. R. Andrews

    2015-09-01

    Full Text Available La tuberculosis (TB continúa concentrada de manera desproporcionada entre los pobres, pero los determinantes conocidos de reactivación de la TB pueden no explicar las desigualdades observadas en las tasas de enfermedad según la riqueza. En el presente estudio, mediante la revisión de datos sobre desigualdades en TB en la India y la distribución de factores de riesgo de TB conocidos según riqueza, se describe cómo los patrones de mezcla social pueden estar contribuyendo a las desigualdades en TB. La mezcla social por afinidad selectiva según la riqueza, por la cual es más probable que las personas entren en contacto con otras personas de orígenes socioeconómicos similares, amplifica las pequeñas diferencias en el riesgo de TB y genera grandes desigualdades a nivel poblacional. A medida que las desigualdades y la asortatividad (o afinidad selectiva aumentan, se hace más difícil controlar la TB; este efecto queda enmascarado cuando se examinan solamente promedios poblacionales de parámetros epidemiológicos, tales como las tasas de detección de casos. El estudio ilustra cómo los esfuerzos de control de TB pueden beneficiarse a partir de una orientación preferencial hacia los pobres. En la India, una intervención a escala equivalente podría tener un impacto sustancialmente mayor si se orientara a quienes viven por debajo de la línea de pobreza que el de una estrategia a toda la población. Además de las eficiencias potenciales de focalizar en poblaciones en más alto riesgo, los esfuerzos de control de la TB podrían llevar a una mayor reducción en el número de casos secundarios de TB por cada caso primario diagnosticado si es que tales esfuerzos fuesen preferencialmente orientados hacia los pobres. El estudio destaca la necesidad de recolectar datos programáticos sobre las desigualdades en TB e incorporar de manera explícita consideraciones de equidad en los planes de control de la TB.

  20. Adolescentes con conducta antisocial y autodestructiva: estudio epidemiológico y nuevas técnicas terapéuticas

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    Susana Quiroga

    2005-12-01

    Full Text Available El proceso de continuidad y de vínculo que va desde la adolescencia temprana hasta el final de la adolescencia tardía ha recibido poca atención en población no clínica y prácticamente una falta de atención en las poblaciones de alto riesgo. En el Programa de Psicología Clínica para Adolescentes, Sede Regional Sur-UBA, se realizan actividades de Prevención, Asistencia e Investigación para adolescentes que presentan alta vulnerabilidad psíquica y somática relacionada con el medio familiar y socioeconómico en el que viven. Los estudios epidemiológicos realizados en la población consultante señalaron una alta prevalencia de ideaciones e intentos suicidas, Alexitimia y Sucesos de Vida Traumáticos así como una desestimación del riesgo que conduce a conductas de pasaje al acto. Por otra parte, se identificaron tres momentos de Deserción, para lo cual se desarrollaron nuevas técnicas de abordaje terapéutico, entre ellas: Grupo de Encuadre Vincular y Representacional (GEVR y Grupo de Terapia Focalizada (GTF.The continuity and bonding process that stretches from early adolescence to the end of adolescence has been paid little attention in non-clinical populations and has almost been neglected in high-risk populations. In the Clinical Psychology Programme for Adolescents of the Buenos Aires University, Prevention, Assistance and Research activities are carried out for adolescents with high psychic and somatic vulnerability related to their family constellation and the socio-economic environment where they live. The epidemiological studies done on the consulting population have shown high prevalence of ideations and suicide attempts, Alexithymia and Traumatic Life Events as well as an underestimation of the risk which leads to acting-out behaviours. Besides, three moments of Drop-outs were detected, that was why new therapeutic techniques were developed such as the Bond and Representation Framework Group (BRFG and the Focused Therapy

  1. Aspectos epidemiológicos e anatomopatológicos do hemagiossarcoma em cães: 40 casos (1965-2012

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    Mariana M. Flores

    2012-12-01

    Full Text Available Os aspectos epidemiológicos e anatomopatológicos de casos de hemangiossarcoma em cães da Região Central do RS foram estudados. Dos casos avaliados (n=40, cães idosos e da raça Pastor Alemão foram nitidamente os mais afetados (72,2% e 20% dos casos, respectivamente, visto que na população total de cães necropsiados nesse mesmo período (n=7.063 essa faixa etária e raça tiveram comparativamente uma prevalência bem mais baixa (14,6% e 10,1% dos casos, respectivamente. Na necropsia (n=40, os tumores ocorreram quase sempre como nódulos (92,5% e, menos frequentemente, como massas (37,5%, e afetaram principalmente: baço (62,5%, pulmão (60%, fígado (52,5%, peritônio (42,5%, rim (37,5%, encéfalo (30%, pleura (25% e coração (22,5%. Hemoperitônio (42,5% e, consequentemente, anemia (22,5% foram vistos com certa frequência. Na histologia (n=25, os hemangiossarcomas eram principalmente bem diferenciados (84%, de baixo grau (64% e com estroma escasso (84%, mas frequentemente (68% havia áreas com células demonstrando algum grau de atipia. Necrose, hemorragia e trombose foram vistos em todos os casos, mas hematopoiese extramedular (28% e proliferação angiomatosa benigna (12% foram achados menos comuns. Na imuno- -histoquímica (n=24, utilizando anticorpo anti-fator de von Willebrand, todos os casos demonstraram marcação de intensidade variável com um padrão citoplasmático finamente granular. Em relação à classificação anatômica, 55% dos hemangiossarcomas foram considerados como multicêntricos, 30% como primários com metástase(s e 15% como solitários. Esse artigo discute esses resultados e propõe, com base em combinações de órgãos afetados, um esquema de separação entre hemangiossarcomas primário com metástase(s e multicêntrico, a fim de tentar homogeneizar a maneira com que patologistas veterinários referem-se a esse neoplasma.

  2. Aspectos epidemiológicos, clínicos e anatomopatológicos da infecção por Gurltia paralysans em gatos

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    Monique Togni

    2013-03-01

    Full Text Available Nos últimos 20 anos, uma doença neurológica desconhecida acometeu populações de gatos da Região da Campanha do RS e tornou-se um desafio diagnóstico para os veterinários locais. Os gatos afetados desenvolviam inicialmente paralisia da cauda, seguida de paraparesia progressiva nos membros pélvicos, alteração da marcha, posição plantígrada e ataxia proprioceptiva. Após longos períodos de evolução clínica (12-24 meses, quando se tornavam marcadamente paraparéticos e começavam a apresentar escaras de decúbito, eram sacrificados pelos proprietários. Na necropsia, demonstravam graus variados de atrofia dos músculos pélvicos e algum grau de avermelhamento das meninges entre T10 e L7, devido à presença de miríades de pequenos vasos sanguíneos, uma típica lesão varicosa, semelhante a um hamartoma vascular. Histologicamente, tais lesões consistiam de distensão do espaço subaracnóideo por vasos sanguíneos dilatados e tortuosos, repletos de sangue e, ocasionalmente, de trombos, que ocluíam parcial ou totalmente seus lúmens. Essas varizes venulares eram aleatoriamente circundadas por infiltrado inflamatório granulomatoso ou linfocítico com pequenos focos de eosinófilos maduros. No lúmen das vênulas varicosas havia secções transversais e longitudinais de parasitos. Com base na morfologia desses parasitos, em sua localização anatômica (vasos sanguíneos meníngeos e na espécie afetada (gato, o nematódeo foi identificado como Gurltia paralysans. O objetivo desse trabalho é apresentar em detalhes os aspectos epidemiológicos, clínicos e anatomopatológicos dessa intrigante mielopatia de gatos e estabelecer definitivamente seu diagnóstico definitivo: paraplegia crural parasitária felina, uma doença descoberta no Chile, na década de 1930, e agora, pela primeira vez, descrita no Brasil.

  3. Bronquiectasia localizada e multissegmentar: perfil clínico-epidemiológico e resultado do tratamento cirúrgico em 67 casos

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    GOMES NETO ANTERO

    2001-01-01

    Full Text Available A bronquiectasia, doença rara no Primeiro Mundo, tem alta prevalência nos países em desenvolvimento. No Brasil, as principais causas são infecções respiratórias, virais ou bacterianas na infância e tuberculose. A antibioticoterapia diminui consideravelmente a morbidade, mas nos pacientes com sintomatologia persistente, a ressecção cirúrgica oferece maior possibilidade de cura ou melhor qualidade de vida. Objetivos: Avaliar prospectivamente o perfil clínico-epidemiológico de pacientes com bronquiectasia e o resultado do tratamento cirúrgico em dois hospitais da rede pública de saúde de Fortaleza (CE, na região Nordeste do Brasil. Casuística e método: Foram estudados dados demográficos, etiologia da doença e complicações e sucesso terapêutico da cirurgia de 67 portadores de bronquiectasia operados de agosto de 1989 a março de 1999. Resultados: Os pacientes, 39 mulheres e 28 homens, tinham idade média de 32,5 ± 14,1 anos e as causas mais freqüentes da bronquiectasia foram infecções bacterianas ou virais (44,8% e tuberculose (31,3%. A doença era localizada em 46 pacientes e multissegmentar em 21, sendo bilateral em seis. Não houve óbito cirúrgico e as complicações pós-operatórias foram mais freqüentes nos pacientes com bronquiectasia multissegmentar (9/21 versus 6/46, p = 0,011. Dos 62 pacientes com seguimento, 49 foram curados, dez melhoraram e três não obtiveram benefícios. O resultado foi excelente em 39 pacientes com doença localizada e em dez com doença multissegmentar (p < 0,001. Conclusão: O resultado mostra dois grupos distintos de pacientes: os com bronquiectasia localizada, que apresentam menos complicações cirúrgicas e melhores resultados pós-operatórios, e os com bronquiectasia multissegmentar.

  4. Epidemia de dengue em Fortaleza, Ceará: inquérito soro-epidemiológico aleatório

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    Pedro F. C. Vasconcelos

    1998-10-01

    Full Text Available OBJETIVO: Seguindo-se à epidemia de dengue (DEN, em 1994, em Fortaleza, Ceará, causada pelo sorotipo 2 (DEN-2, realizou-se inquérito soro-epidemiológico aleatório para avaliar e dimensionar o impacto da mesma e a prevalência do dengue por distrito sanitário. MÉTODO: Foi aplicado questionário contendo informações gerais, condições socio-econômicas, informações sobre o quadro clínico e tempo de doença. A amostra foi calculada para estimar uma prevalência de 20%, com erro relativo de 10%, e intervalo de confiança de 95% (erro a de 5%. O sorteio e as análises foram realizadas por meio de computador usando programas apropriados. RESULTADOS E CONCLUSÕES: Foram colhidas 1.341 amostras de soro de 9 distritos sanitários, testadas por inibição da hemaglutinação, sendo classificadas como negativas e positivas (respostas primária - RP e secundária - RS. Foram reativas 588 (44% amostras, sendo 93 (7% RP e 495 (37% RS. A prevalência global em Fortaleza variou de 21% a 71%. Houve 41% (243/588 de infecções assintomáticas (IA e 59% (346/588 sintomáticas (IS. Não houve diferença da prevalência quanto ao sexo, faixa etária e escolaridade, ao contrário da condição socioeconômica que apresentou diferenças estatisticamente significantes (p < 0,001. Ocorreram mais IA (p<0,001 e IS (p<0,0001 em casos de RS que RP, com significância estatística em ambos os sexos. Os sintomas mais prevalentes no casos confirmados foram febre, cefaléia, mialgias, exantema, mal estar geral, tontura e artralgias, sendo que prurido, dor ocular, exantema e gengivorragia foram estatisticamente significantes (p<0,005. Tontura e artralgias foram mais associados com RS que com RP, havendo diferenças estatísticas (p <0,05.

  5. Perfil epidemiológico de las enfermedades profesionales en Alicante, 2002-2005 Epidemiological profile of occupational diseases in Alicante, 2002-2005

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    Senén Berenguer-Ortuño

    2009-03-01

    Full Text Available Objetivo: Describir el patrón epidemiológico de las enfermedades profesionales (EEPP en la provincia de Alicante entre los años 2002-2005. Métodos: Estudio transversal. La fuente de información procede de los partes del registro de EEPP notificadas en Alicante. Las enfermedades incluidas han sido los trastornos musculoesqueléticos (TME del miembro superior, dermatitis y asma. Como factores laborales y personales se han considerado la edad, el sexo, el puesto de trabajo, el tamaño de la empresa, y la antigüedad laboral. Se han estimado las tasas de incidencia utilizando los datos de población ocupada de la provincia, así como las razones de incidencia con los intervalos de confianza al 95% (IC 95% para las distintas variables consideradas. Resultados: Se registraron 645 casos de EEPP, de éstas 607 corresponden a las patologías seleccionadas con una incidencia de 22,67 casos por 100.000 trabajadores. 525 son TME del miembro superior, 68 dermatitis y 14 de asma. Conclusiones: Los TME del miembro superior representan en la provincia de Alicante la principal EEPP declarada. Se observan diferencias entre los tres grupos de EEPP en Alicante entre 2002-2005, según sexo, edad, actividad económica de la empresa y antigüedad en el puesto de trabajo.Objective: Describe the epidemiological pattern of the occupational diseases in the province of Alicante between 2002-2005. Methods: Cross-sectional study. The source of information comes from the reports of the occupational diseases registration notified in Alicante 2002-2005. The diseases have been included upper limb musculoskeletal disorders (UL-MSD, dermatitis and asthma. As working and personal factors have been considered age, sex, occupation, firm size and length of employment. The incidence rates were estimated, using workers report of Alicante, and the reasons for incidence with the confidence intervals yours (CI 95% for the different variables considered. Results: 645 cases of

  6. Nutritional biomarkers for objective dietary assessment.

    Science.gov (United States)

    Kuhnle, Gunter G C

    2012-04-01

    The accurate assessment of dietary exposure is important in investigating associations between diet and disease. Research in nutritional epidemiology, which has resulted in a large amount of information on associations between diet and chronic diseases in the last decade, relies on accurate assessment methods to identify these associations. However, most dietary assessment instruments rely to some extent on self-reporting, which is prone to systematic bias affected by factors such as age, gender, social desirability and approval. Nutritional biomarkers are not affected by these and therefore provide an additional, alternative method to estimate intake. However, there are also some limitations in their application: they are affected by inter-individual variations in metabolism and other physiological factors, and they are often limited to estimating intake of specific compounds and not entire foods. It is therefore important to validate nutritional biomarkers to determine specific strengths and limitations. In this perspective paper, criteria for the validation of nutritional markers and future developments are discussed. Copyright © 2012 Society of Chemical Industry.

  7. Kadar Asam Urat Serum sebagai Biomarker Preeklamsi

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    Neli Sumanti

    2013-06-01

    Full Text Available Preeclampsia remains a health problem that becomes one of the causes of maternal deaths besides bleeding and infection. The etiology and pathogenesis of preeclampsia are unclear. Increased serum uric acid levels is seen simultaneously with the increase of blood pressure and occurred before the onset of proteinuria. Therefore, the uric acid can be used as a biomarker. The aim of this study was to analyze the serum uric acid levels between normal and preeclampsia pregnancies. The study was conducted in Dr.Hasan Sadikin Hospital Bandung between March and May 2011, using cross sectional study design. Subjects were 45 inpartu normal pregnant women as control and 44 in partu pregnant women with preeclampsia accordance with inclusion and exclusion criteria. Levels of uric acid in normal pregnancy are 3,43 ±0.14 mg/dL. In this study uric acid levels resulting in cut-off levels of 4,8 mg/dL with a sensitivity value of 93%, and specificity 80%. Conclusions: uric acid levels in at term preeclampsia are higher compared with normal pregnancies. Increased levels of uric acid can be considered as one of biomarkers of preeclampsia, hence the serum uric acid levels used as serial examinations in pregnant women during antenatal care.

  8. Metabolic Imaging Biomarkers of Postradiotherapy Xerostomia

    International Nuclear Information System (INIS)

    Cannon, Blake; Schwartz, David L.; Dong Lei

    2012-01-01

    Purpose: Xerostomia is a major complication of head and neck radiotherapy (RT). Available xerostomia measures remain flawed. [ 18 F]fluorodeoxyglucose-labeled positron emission tomography-computed tomography (FDG-PET-CT) is routinely used for staging and response assessment of head and neck cancer. We investigated quantitative measurement of parotid gland FDG uptake as a potential biomarker for post-RT xerostomia. Methods and Materials: Ninety-eight locally advanced head and neck cancer patients receiving definitive RT underwent baseline and post-RT FDG-PET-CT on a prospective imaging trial. A separate validation cohort of 14 patients underwent identical imaging while prospectively enrolled in a second trial collecting sialometry and patient-reported outcomes. Radiation dose and pre- and post-RT standard uptake values (SUVs) for all voxels contained within parotid gland ROI were deformably registered. Results: Average whole-gland or voxel-by-voxel models incorporating parotid D Met (defined as the pretreatment parotid SUV weighted by dose) accurately predicted posttreatment changes in parotid FDG uptake (e.g., fractional parotid SUV). Fractional loss of parotid FDG uptake closely paralleled early parotid toxicity defined by posttreatment salivary output (p Met may potentially be used to guide function-sparing treatment planning. Prospective validation of FDG-PET-CT as a convenient, quantifiable imaging biomarker of parotid function is warranted and ongoing.

  9. Biomarkers and Mechanisms of FANCD2 Function

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    Henning Willers

    2008-01-01

    Full Text Available Genetic or epigenetic inactivation of the pathway formed by the Fanconi anemia (FA and BRCA1 proteins occurs in several cancer types, making the affected tumors potentially hypersensitive to DNA cross-linkers and other chemotherapeutic agents. It has been proposed that the inability of FA/BRCA-defective cells to form subnuclear foci of effector proteins, such as FANCD2, can be used as a biomarker to aid individualization of chemotherapy. We show that FANCD2 inactivation not only renders cells sensitive to cross-links, but also oxidative stress, a common effect of cancer therapeutics. Oxidative stress sensitivity does not correlate with FANCD2 or RAD51 foci formation, but associates with increased γH2AX foci levels and apoptosis. Therefore, FANCD2 may protect cells against cross-links and oxidative stress through distinct mechanisms, consistent with the growing notion that the pathway is not linear. Our data emphasize the need for multiple biomarkers, such as γH2AX, FANCD2, and RAD51, to capture all pathway activities.

  10. Discovering Alzheimer Genetic Biomarkers Using Bayesian Networks

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    Fayroz F. Sherif

    2015-01-01

    Full Text Available Single nucleotide polymorphisms (SNPs contribute most of the genetic variation to the human genome. SNPs associate with many complex and common diseases like Alzheimer’s disease (AD. Discovering SNP biomarkers at different loci can improve early diagnosis and treatment of these diseases. Bayesian network provides a comprehensible and modular framework for representing interactions between genes or single SNPs. Here, different Bayesian network structure learning algorithms have been applied in whole genome sequencing (WGS data for detecting the causal AD SNPs and gene-SNP interactions. We focused on polymorphisms in the top ten genes associated with AD and identified by genome-wide association (GWA studies. New SNP biomarkers were observed to be significantly associated with Alzheimer’s disease. These SNPs are rs7530069, rs113464261, rs114506298, rs73504429, rs7929589, rs76306710, and rs668134. The obtained results demonstrated the effectiveness of using BN for identifying AD causal SNPs with acceptable accuracy. The results guarantee that the SNP set detected by Markov blanket based methods has a strong association with AD disease and achieves better performance than both naïve Bayes and tree augmented naïve Bayes. Minimal augmented Markov blanket reaches accuracy of 66.13% and sensitivity of 88.87% versus 61.58% and 59.43% in naïve Bayes, respectively.

  11. Protein Biomarkers of Periodontitis in Saliva

    Science.gov (United States)

    Taylor, John J.

    2014-01-01

    Periodontitis is a chronic inflammatory condition of the tissues that surround and support the teeth and is initiated by inappropriate and excessive immune responses to bacteria in subgingival dental plaque leading to loss of the integrity of the periodontium, compromised tooth function, and eventually tooth loss. Periodontitis is an economically important disease as it is time-consuming and expensive to treat. Periodontitis has a worldwide prevalence of 5–15% and the prevalence of severe disease in western populations has increased in recent decades. Furthermore, periodontitis is more common in smokers, in obesity, in people with diabetes, and in heart disease patients although the pathogenic processes underpinning these links are, as yet, poorly understood. Diagnosis and monitoring of periodontitis rely on traditional clinical examinations which are inadequate to predict patient susceptibility, disease activity, and response to treatment. Studies of the immunopathogenesis of periodontitis and analysis of mediators in saliva have allowed the identification of many potentially useful biomarkers. Convenient measurement of these biomarkers using chairside analytical devices could form the basis for diagnostic tests which will aid the clinician and the patient in periodontitis management; this review will summarise this field and will identify the experimental, technical, and clinical issues that remain to be addressed before such tests can be implemented. PMID:24944840

  12. Sleep electroencephalography as a biomarker in depression

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    Steiger A

    2015-04-01

    Full Text Available Axel Steiger, Marcel Pawlowski, Mayumi Kimura Max Planck Institute of Psychiatry, Munich, Germany Abstract: The sleep electroencephalogram (EEG provides biomarkers of depression, which may help with diagnosis, prediction of therapy response, and prognosis in the treatment of depression. In patients with depression, characteristic sleep EEG changes include impaired sleep continuity, disinhibition of rapid-eye-movement (REM sleep, and impaired non-REM sleep. Most antidepressants suppress REM sleep in depressed patients, healthy volunteers, and in animal models. REM suppression appears to be an important, but not an absolute requirement, for antidepressive effects of a substance. Enhanced REM density, a measure for frequency of REM, characterizes high-risk probands for affective disorders. REM-sleep changes were also found in animal models of depression. Sleep-EEG variables were shown to predict the response to treatment with antidepressants. Furthermore, certain clusters of sleep EEG variables predicted the course of the disorder for several years. Some of the predicted sleep EEG markers appear to be related to hypothalamic–pituitary–adrenal system activity. Keywords: biomarkers, depression, sleep EEG, antidepressants, prediction, animal models

  13. Barium Titanate Nanoparticles for Biomarker Applications

    International Nuclear Information System (INIS)

    Matar, O; Hondow, N S; Brydson, R M D; Milne, S J; Brown, A P; Posada, O M; Wälti, C; Saunders, M; Murray, C A

    2015-01-01

    A tetragonal crystal structure is required for barium titanate nanoparticles to exhibit the nonlinear optical effect of second harmonic light generation (SHG) for use as a biomarker when illuminated by a near-infrared source. Here we use synchrotron XRD to elucidate the tetragonal phase of commercially purchased tetragonal, cubic and hydrothermally prepared barium titanate (BaTiO 3 ) nanoparticles by peak fitting with reference patterns. The local phase of individual nanoparticles is determined by STEM electron energy loss spectroscopy (EELS), measuring the core-loss O K-edge and the Ti L 3 -edge energy separation of the t 2g , e g peaks. The results show a change in energy separation between the t 2g and e g peak from the surface and core of the particles, suggesting an intraparticle phase mixture of the barium titanate nanoparticles. HAADF-STEM and bright field TEM-EDX show cellular uptake of the hydrothermally prepared BaTiO 3 nanoparticles, highlighting the potential for application as biomarkers. (paper)

  14. Diagnosis of Periodontal Diseases by Biomarkers

    Science.gov (United States)

    Kido, Jun-Ichi; Hino, Mami; Bando, Mika; Hiroshima, Yuka

    Many middle aged and old persons take periodontal diseases that mainly cause teeth loss and result in some systemic diseases. The prevention of periodontal diseases is very important for oral and systemic health, but the present diagnostic examination is not fully objective and suitable. To diagnose periodontal diseases exactly, some biomarkers shown inflammation, tissue degradation and bone resorption, in gingival crevicular fluid (GCF) and saliva are known. We demonstrated that GCF levels of calprotectin, inflammation-related protein, and carboxy-terminal propeptide of type I procollagen, bone metabolism-related protein, were associated with clinical condition of periodontal diseases, and suggested that these proteins may be useful biomarkers for periodontal diseases. Recently, determinations of genes and proteins by using microdevices are studied for diagnosis of some diseases. We detected calprotectin protein by chemiluminescent immunoassay on a microchip and showed the possibility of specific and quantitative detection of calprotectin in a very small amount of GCF. To determine plural markers in GCF by using microdevices contributes to develop accurate, objective diagnostic system of periodontal diseases.

  15. Retinal Layer Abnormalities as Biomarkers of Schizophrenia.

    Science.gov (United States)

    Samani, Niraj N; Proudlock, Frank A; Siram, Vasantha; Suraweera, Chathurie; Hutchinson, Claire; Nelson, Christopher P; Al-Uzri, Mohammed; Gottlob, Irene

    2018-06-06

    Schizophrenia is associated with several brain deficits, as well as visual processing deficits, but clinically useful biomarkers are elusive. We hypothesized that retinal layer changes, noninvasively visualized using spectral-domain optical coherence tomography (SD-OCT), may represent a possible "window" to these abnormalities. A Leica EnvisuTM SD-OCT device was used to obtain high-resolution central foveal B-scans in both eyes of 35 patients with schizophrenia and 50 demographically matched controls. Manual retinal layer segmentation was performed to acquire individual and combined layer thickness measurements in 3 macular regions. Contrast sensitivity was measured at 3 spatial frequencies in a subgroup of each cohort. Differences were compared using adjusted linear models and significantly different layer measures in patients underwent Spearman Rank correlations with contrast sensitivity, quantified symptoms severity, disease duration, and antipsychotic medication dose. Total retinal and photoreceptor complex thickness was reduced in all regions in patients (P layer (P layer (P layer thickness (R = -.47, P = .005). Our novel findings demonstrate considerable retinal layer abnormalities in schizophrenia that are related to clinical features and visual function. With time, SD-OCT could provide easily-measurable biomarkers to facilitate clinical assessment and further our understanding of the disease.

  16. Población de 80 y más años en chile: Una visión preliminar desde el punto de vista epidemiológico

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    Dr. C. Gonzalo valdivia

    2012-01-01

    Full Text Available Chile está en fase avanzada de transición epidemiológica predominando las enfermedades crónicas como problemas de salud. La creciente expectativa de vida al nacer ha permitido configurar una numerosa cohorte de adultos de 80 años y más que superó su expectativa al nacer. El análisis de este subgrupo, es indispensable para el adecuado cuidado de su salud. La alta mortalidad de este grupo deriva de enfermedades circulatorias, tumorales y respiratorias. Los AVISA complementan la información epidemiológica de este grupo, agregando a las patologías señaladas otras condiciones específicas que orientan mejor a identificar sus prioridades en salud. La Encuesta Nacional de Salud 2009-10, por el carácter inclusivo de su muestra, revela en este grupo de edad el predominio de las enfermedades crónicas (hipertensión arterial, diabetes, dislipidemias y de sus factores de riesgo. Se pesquisan altos niveles de deterioro cognitivo, de hipotiroidismo y de síntomas músculo esqueléticos, persistiendo rezagos de factores de riesgo conductuales (tabaco, alcohol. La cobertura efectiva de las enfermedades crónicas prevalentes debe constituirse en un objetivo clínico a mejorar en este grupo de edad.

  17. Um estudo etno-epidemiológico da violência urbana na cidade de Salvador, Bahia, Brasil: os atos de extermínio como objeto de análise

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    Mônica Nunes

    2005-04-01

    Full Text Available O presente estudo, reunindo uma vertente epidemiológica e uma vertente antropológica, permitiu evidenciar os significados sociais subjacentes a dados indicados pela comparação do monitoramento de diferenciais da distribuição das taxas de mortalidade por homicídios em um bairro de Salvador, realizados em dois períodos: o primeiro situado entre 1988 e 1994 e o segundo, entre 1994 e 2000. O estudo etnográfico indicou que, no primeiro período, ocorreu o extermínio de muitas pessoas consideradas delinqüentes e o assassinato de muitos moradores no bairro, o que, no estudo epidemiológico, corresponde a um aumento na taxa de mortalidade por causas externas. Já entre 91-94, observa-se um decréscimo na taxa de mortalidade, coincidindo, no trabalho de campo, com o período considerado de "acalmia". Na segunda metade da década de noventa, observa-se um novo aumento da taxa de homicídios na área de estudo, embora os moradores revelem uma imagem pacífica do bairro. O presente estudo realiza uma hermenêutica da violência nesse bairro, especialmente dos atos de extermínio, e das dinâmicas sociais que a envolviam nos seus diversos períodos.

  18. Um estudo etno-epidemiológico da violência urbana na cidade de Salvador, Bahia, Brasil: os atos de extermínio como objeto de análise

    Directory of Open Access Journals (Sweden)

    Paim Jairnilson Silva

    2005-01-01

    Full Text Available O presente estudo, reunindo uma vertente epidemiológica e uma vertente antropológica, permitiu evidenciar os significados sociais subjacentes a dados indicados pela comparação do monitoramento de diferenciais da distribuição das taxas de mortalidade por homicídios em um bairro de Salvador, realizados em dois períodos: o primeiro situado entre 1988 e 1994 e o segundo, entre 1994 e 2000. O estudo etnográfico indicou que, no primeiro período, ocorreu o extermínio de muitas pessoas consideradas delinqüentes e o assassinato de muitos moradores no bairro, o que, no estudo epidemiológico, corresponde a um aumento na taxa de mortalidade por causas externas. Já entre 91-94, observa-se um decréscimo na taxa de mortalidade, coincidindo, no trabalho de campo, com o período considerado de "acalmia". Na segunda metade da década de noventa, observa-se um novo aumento da taxa de homicídios na área de estudo, embora os moradores revelem uma imagem pacífica do bairro. O presente estudo realiza uma hermenêutica da violência nesse bairro, especialmente dos atos de extermínio, e das dinâmicas sociais que a envolviam nos seus diversos períodos.

  19. Avaliação do risco epidemiológico e do desempenho dos programas de controle de tuberculose nas Regiões de Saúde do estado de Santa Catarina, 2003 a 2010

    Directory of Open Access Journals (Sweden)

    Sergio Adam Mendonça

    Full Text Available OBJETIVO: avaliar o risco epidemiológico e o desempenho dos programas de controle de tuberculose segundo Regiões de Saúde do estado de Santa Catarina, Brasil, no período de 2003 a 2010. MÉTODOS: estudo ecológico com dados fornecidos pela vigilância epidemiológica estadual, compreendendo 4 indicadores de risco e 11 de desempenho do programa; calculou-se a mediana de cada indicador por Região e atribuiu-se pontos conforme a distribuição percentilar, permitindo-se a criação de um índice de gravidade. RESULTADOS: verificou-se a existência de diferentes níveis de risco de morbimortalidade e distintos índices de desempenho das ações de controle da tuberculose nas Regiões de Saúde; o índice de gravidade permitiu identificar 6 Regiões de maior gravidade, 9 intermediárias e 6 de menor gravidade, com diferenças nos escores de risco e desempenho (p<0,001. CONCLUSÃO: evidenciou-se grande variedade de nichos de gravidade distribuídos nas diversas Regiões, bem como diversidade no empenho da gestão administrativa para seu enfrentamento.

  20. Avaliação da qualidade dos dados, valor preditivo positivo, oportunidade e representatividade do sistema de vigilância epidemiológica da dengue no Brasil, 2005 a 2009

    Directory of Open Access Journals (Sweden)

    Jakeline Ribeiro Barbosa

    Full Text Available OBJETIVO: avaliar a qualidade dos dados, o valor preditivo positivo (VPP, a oportunidade e a representatividade do sistema de vigilância epidemiológica da dengue no Brasil entre 2005 e 2009. MÉTODOS: estudo de avaliação, com análise dos dados de dengue do Sistema de Informação de Agravos de Notificação (Sinan conforme atributos selecionados da metodologia do Centers for Disease Control and Prevention (Atlanta/GA, Estados Unidos da América. RESULTADOS: houve melhora na qualidade dos dados quanto a sua consistência; o VPP dos casos de dengue variou de 34 a 65%; o sistema apresentou uma mediana de oportunidade para notificação dos casos de 3 dias e revelou-se representativo, permitindo conhecer a situação da doença no país. CONCLUSÃO: o sistema de vigilância da dengue no Brasil mostrou-se consistente, com valor preditivo positivo expressivo, oportuno para notificação de casos e representativo, capaz de detectar tendência de mudança no perfil epidemiológico da doença.

  1. CSF biomarker variability in the Alzheimer's Association quality control program

    NARCIS (Netherlands)

    Mattsson, N.; Andreasson, U.; Persson, S.; Carrillo, M.C.; Collins, S.; Chalbot, S.; Cutler, N.; Dufour-Rainfray, D.; Fagan, A.M.; Heegaard, N.H.H.; Robin Hsiung, G.Y.; Hyman, B.; Iqbal, K.; Lachno, D.R.; Lleo, A.; Lewczuk, P.; Molinuevo, J.L.; Parchi, P.; Regeniter, A.; Rissman, R.; Rosenmann, H.; Sancesario, G.; Schroder, J.; Shaw, L.M.; Teunissen, C.E.; Trojanowski, J.Q.; Vanderstichele, H.; Vandijck, M.; Verbeek, M.M.; Zetterberg, H.; Blennow, K.; Kaser, S.A.; et al.,

    2013-01-01

    BACKGROUND: The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories. METHODS: Data

  2. CSF biomarker variability in the Alzheimer's Association quality control program

    NARCIS (Netherlands)

    Mattsson, N.; Andreasson, U.; Persson, S.; Carrillo, M.C.; Collins, S.; Chalbot, S.; Cutler, N.; Dufour-Rainfray, D.; Fagan, A.M.; Heegaard, N.H.H.; Hsiung, G.Y.R.; Hyman, B.; Iqbal, K.; Lachno, D.R.; Lleo, A.; Lewczuk, P.; Molinuevo, J.L.; Parchi, P.; Regeniter, A.; Rissman, R.; Rosenmann, H.; Sancesario, G.; Schroder, J.; Shaw, L.M.; Teunissen, C.E.; Trojanowski, J.Q.; Vanderstichele, H.; Vandijck, M.; Verbeek, M.M.; Zetterberg, H.; Blennow, K.; Kaser, S.A.

    2013-01-01

    Background: The cerebrospinal fluid (CSF) biomarkers amyloid beta 1-42, total tau, and phosphorylated tau are used increasingly for Alzheimer's disease (AD) research and patient management. However, there are large variations in biomarker measurements among and within laboratories. Methods: Data

  3. Cardiovascular biomarkers and sex: the case for women.

    Science.gov (United States)

    Daniels, Lori B; Maisel, Alan S

    2015-10-01

    Measurement of biomarkers is a critical component of cardiovascular care. Women and men differ in their cardiac physiology and manifestations of cardiovascular disease. Although most cardiovascular biomarkers are used by clinicians without taking sex into account, sex-specific differences in biomarkers clearly exist. Baseline concentrations of many biomarkers (including cardiac troponin, natriuretic peptides, galectin-3, and soluble ST2) differ in men versus women, but these sex-specific differences do not generally translate into a need for differential sex-based cut-off points. Furthermore, most biomarkers are similarly diagnostic and prognostic, regardless of sex. Two potential exceptions are cardiac troponins measured by high-sensitivity assay, and proneurotensin. Troponin levels are lower in women than in men and, with the use of high-sensitivity assays, sex-specific cut-off points might improve the diagnosis of myocardial infarction. Proneurotensin is a novel biomarker that was found to be predictive of incident cardiovascular disease in women, but not men, and was also predictive of incident breast cancer. If confirmed, proneurotensin might be a unique biomarker of disease risk in women. With any biomarker, an understanding of sex-specific differences might improve its use and might also lead to an enhanced understanding of the physiological differences between the hearts of men and women.

  4. Application of bio-marker to study on tumor radiosensitivity

    International Nuclear Information System (INIS)

    Guo Wanfeng; Ding Guirong; Han Liangfu

    2001-01-01

    To definite tumor radiosensitivity is important for applying the schedules of individualization of patient radiotherapy. Many laboratories were carrying on the research which predict the tumor radiosensitivity with one bio-marker or/and multi-bio-marker in various levels. At present has not witnessed the specific bio-marker, but it provides an excellent model for predicting tumor radiosensitivity

  5. Metabolomics as a tool in the identification of dietary biomarkers.

    Science.gov (United States)

    Gibbons, Helena; Brennan, Lorraine

    2017-02-01

    Current dietary assessment methods including FFQ, 24-h recalls and weighed food diaries are associated with many measurement errors. In an attempt to overcome some of these errors, dietary biomarkers have emerged as a complementary approach to these traditional methods. Metabolomics has developed as a key technology for the identification of new dietary biomarkers and to date, metabolomic-based approaches have led to the identification of a number of putative biomarkers. The three approaches generally employed when using metabolomics in dietary biomarker discovery are: (i) acute interventions where participants consume specific amounts of a test food, (ii) cohort studies where metabolic profiles are compared between consumers and non-consumers of a specific food and (iii) the analysis of dietary patterns and metabolic profiles to identify nutritypes and biomarkers. The present review critiques the current literature in terms of the approaches used for dietary biomarker discovery and gives a detailed overview of the currently proposed biomarkers, highlighting steps needed for their full validation. Furthermore, the present review also evaluates areas such as current databases and software tools, which are needed to advance the interpretation of results and therefore enhance the utility of dietary biomarkers in nutrition research.

  6. Oxidative stress biomarkers in Oreochromis niloticus as early ...

    African Journals Online (AJOL)

    2018-04-10

    Apr 10, 2018 ... warning signals in assessing pollution from acid mine drainage and ... fish species Oreochromis niloticus as a bio-indicator organism in active ... Key water quality parameters, including ... Biomarkers can provide early warning of potential higher- ...... CT (2001) The use of biomarkers in Ecological Risk.

  7. The future of blood-based biomarkers for Alzheimer's disease

    DEFF Research Database (Denmark)

    Henriksen, Kim; O'Bryant, Sid E; Hampel, Harald

    2014-01-01

    Treatment of Alzheimer's disease (AD) is significantly hampered by the lack of easily accessible biomarkers that can detect disease presence and predict disease risk reliably. Fluid biomarkers of AD currently provide indications of disease stage; however, they are not robust predictors of disease...

  8. Cancer Biomarker Discovery: Lectin-Based Strategies Targeting Glycoproteins

    Directory of Open Access Journals (Sweden)

    David Clark

    2012-01-01

    Full Text Available Biomarker discovery can identify molecular markers in various cancers that can be used for detection, screening, diagnosis, and monitoring of disease progression. Lectin-affinity is a technique that can be used for the enrichment of glycoproteins from a complex sample, facilitating the discovery of novel cancer biomarkers associated with a disease state.

  9. Multiomics Data Triangulation for Asthma Candidate Biomarkers and Precision Medicine.

    Science.gov (United States)

    Pecak, Matija; Korošec, Peter; Kunej, Tanja

    2018-06-01

    Asthma is a common complex disorder and has been subject to intensive omics research for disease susceptibility and therapeutic innovation. Candidate biomarkers of asthma and its precision treatment demand that they stand the test of multiomics data triangulation before they can be prioritized for clinical applications. We classified the biomarkers of asthma after a search of the literature and based on whether or not a given biomarker candidate is reported in multiple omics platforms and methodologies, using PubMed and Web of Science, we identified omics studies of asthma conducted on diverse platforms using keywords, such as asthma, genomics, metabolomics, and epigenomics. We extracted data about asthma candidate biomarkers from 73 articles and developed a catalog of 190 potential asthma biomarkers (167 human, 23 animal data), comprising DNA loci, transcripts, proteins, metabolites, epimutations, and noncoding RNAs. The data were sorted according to 13 omics types: genomics, epigenomics, transcriptomics, proteomics, interactomics, metabolomics, ncRNAomics, glycomics, lipidomics, environmental omics, pharmacogenomics, phenomics, and integrative omics. Importantly, we found that 10 candidate biomarkers were apparent in at least two or more omics levels, thus promising potential for further biomarker research and development and precision medicine applications. This multiomics catalog reported herein for the first time contributes to future decision-making on prioritization of biomarkers and validation efforts for precision medicine in asthma. The findings may also facilitate meta-analyses and integrative omics studies in the future.

  10. Biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy

    DEFF Research Database (Denmark)

    Stenvang, Jan; Kümler, Iben; Nygård, Sune Boris

    2013-01-01

    -standard chemotherapeutic drug will be relatively low in such a patient cohort it is a pre-requisite that such testing is based on predictive biomarkers. This review describes our strategy of biomarker-guided repurposing of chemotherapeutic drugs for cancer therapy, taking the repurposing of topoisomerase I (Top1...

  11. Glycosylation-Based Serum Biomarkers for Cancer Diagnostics and Prognostics.

    Science.gov (United States)

    Kirwan, Alan; Utratna, Marta; O'Dwyer, Michael E; Joshi, Lokesh; Kilcoyne, Michelle

    2015-01-01

    Cancer is the second most common cause of death in developed countries with approximately 14 million newly diagnosed individuals and over 6 million cancer-related deaths in 2012. Many cancers are discovered at a more advanced stage but better survival rates are correlated with earlier detection. Current clinically approved cancer biomarkers are most effective when applied to patients with widespread cancer. Single biomarkers with satisfactory sensitivity and specificity have not been identified for the most common cancers and some biomarkers are ineffective for the detection of early stage cancers. Thus, novel biomarkers with better diagnostic and prognostic performance are required. Aberrant protein glycosylation is well known hallmark of cancer and represents a promising source of potential biomarkers. Glycoproteins enter circulation from tissues or blood cells through active secretion or leakage and patient serum is an attractive option as a source for biomarkers from a clinical and diagnostic perspective. A plethora of technical approaches have been developed to address the challenges of glycosylation structure detection and determination. This review summarises currently utilised glycoprotein biomarkers and novel glycosylation-based biomarkers from the serum glycoproteome under investigation as cancer diagnostics and for monitoring and prognostics and includes details of recent high throughput and other emerging glycoanalytical techniques.

  12. Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome

    NARCIS (Netherlands)

    Hu, Shen; Wang, Jianghua; Leong, Sonya; Xie, Yongming; Yu, Tianwei; Zhou, Hui; Henry, Sharon; Vissink, Arjan; Pijpe, Justin; Kallenberg, Cees; Elashoff, David; Loo, Joseph A.; Wong, David T.

    2007-01-01

    Objective. To identify a panel of protein and messenger RNA (mRNA) biomarkers in human whole saliva (WS) that may be used in the detection of primary Sjogren's syndrome (SS). Methods. Mass spectrometry and expression microarray profiling were used to identify candidate protein and mRNA, biomarkers

  13. A tuberculosis biomarker database: the key to novel TB diagnostics

    Directory of Open Access Journals (Sweden)

    Seda Yerlikaya

    2017-03-01

    Full Text Available New diagnostic innovations for tuberculosis (TB, including point-of-care solutions, are critical to reach the goals of the End TB Strategy. However, despite decades of research, numerous reports on new biomarker candidates, and significant investment, no well-performing, simple and rapid TB diagnostic test is yet available on the market, and the search for accurate, non-DNA biomarkers remains a priority. To help overcome this ‘biomarker pipeline problem’, FIND and partners are working on the development of a well-curated and user-friendly TB biomarker database. The web-based database will enable the dynamic tracking of evidence surrounding biomarker candidates in relation to target product profiles (TPPs for needed TB diagnostics. It will be able to accommodate raw datasets and facilitate the verification of promising biomarker candidates and the identification of novel biomarker combinations. As such, the database will simplify data and knowledge sharing, empower collaboration, help in the coordination of efforts and allocation of resources, streamline the verification and validation of biomarker candidates, and ultimately lead to an accelerated translation into clinically useful tools.

  14. Biomarkers in Prodromal Parkinson Disease: a Qualitative Review.

    Science.gov (United States)

    Cooper, Christine A; Chahine, Lama M

    2016-11-01

    Over the past several years, the concept of prodromal Parkinson disease (PD) has been increasingly recognized. This term refers to individuals who do not fulfill motor diagnostic criteria for PD, but who have clinical, genetic, or biomarker characteristics suggesting risk of developing PD in the future. Clinical diagnosis of prodromal PD has low specificity, prompting the need for objective biomarkers with higher specificity. In this qualitative review, we discuss objectively defined putative biomarkers for PD and prodromal PD. We searched Pubmed and Embase for articles pertaining to objective biomarkers for PD and their application in prodromal cohorts. Articles were selected based on relevance and methodology. Objective biomarkers of demonstrated utility in prodromal PD include ligand-based imaging and transcranial sonography. Development of serum, cerebrospinal fluid, and tissue-based biomarkers is underway, but their application in prodromal PD has yet to meaningfully occur. Combining objective biomarkers with clinical or genetic prodromal features increases the sensitivity and specificity for identifying prodromal PD. Several objective biomarkers for prodromal PD show promise but require further study, including their application to and validation in prodromal cohorts followed longitudinally. Accurate identification of prodromal PD will likely require a multimodal approach. (JINS, 2016, 22, 956-967).

  15. Haematological and serum enzymes biomarkers of heavy metals in ...

    African Journals Online (AJOL)

    Haematological and serum enzymes biomarkers of heavy metals in Chrysichthys Nigrodigitatus and Cynoglossus senegalensis. ... Haematological and serum enzymes activities are predilective biomarkers for the detection and monitoring of aquatic ecosystems pollution. The inclusion of Allium sativum at 1.5g/kg is ...

  16. Imperfect Gold Standards for Kidney Injury Biomarker Evaluation

    Science.gov (United States)

    Betensky, Rebecca A.; Emerson, Sarah C.; Bonventre, Joseph V.

    2012-01-01

    Clinicians have used serum creatinine in diagnostic testing for acute kidney injury for decades, despite its imperfect sensitivity and specificity. Novel tubular injury biomarkers may revolutionize the diagnosis of acute kidney injury; however, even if a novel tubular injury biomarker is 100% sensitive and 100% specific, it may appear inaccurate when using serum creatinine as the gold standard. Acute kidney injury, as defined by serum creatinine, may not reflect tubular injury, and the absence of changes in serum creatinine does not assure the absence of tubular injury. In general, the apparent diagnostic performance of a biomarker depends not only on its ability to detect injury, but also on disease prevalence and the sensitivity and specificity of the imperfect gold standard. Assuming that, at a certain cutoff value, serum creatinine is 80% sensitive and 90% specific and disease prevalence is 10%, a new perfect biomarker with a true 100% sensitivity may seem to have only 47% sensitivity compared with serum creatinine as the gold standard. Minimizing misclassification by using more strict criteria to diagnose acute kidney injury will reduce the error when evaluating the performance of a biomarker under investigation. Apparent diagnostic errors using a new biomarker may be a reflection of errors in the imperfect gold standard itself, rather than poor performance of the biomarker. The results of this study suggest that small changes in serum creatinine alone should not be used to define acute kidney injury in biomarker or interventional studies. PMID:22021710

  17. Salivary proteomic and genomic biomarkers for primary Sjogren's syndrome

    NARCIS (Netherlands)

    Hu, Shen; Wang, Jianghua; Leong, Sonya; Xie, Yongming; Yu, Tianwei; Zhou, Hui; Henry, Sharon; Vissink, Arjan; Pijpe, Justin; Kallenberg, Cees; Elashoff, David; Loo, Joseph A.; Wong, David T.

    Objective. To identify a panel of protein and messenger RNA (mRNA) biomarkers in human whole saliva (WS) that may be used in the detection of primary Sjogren's syndrome (SS). Methods. Mass spectrometry and expression microarray profiling were used to identify candidate protein and mRNA, biomarkers

  18. Novel biomarkers for prediabetes, diabetes, and associated complications

    Science.gov (United States)

    Dorcely, Brenda; Katz, Karin; Jagannathan, Ram; Chiang, Stephanie S; Oluwadare, Babajide; Goldberg, Ira J; Bergman, Michael

    2017-01-01

    The number of individuals with prediabetes is expected to grow substantially and estimated to globally affect 482 million people by 2040. Therefore, effective methods for diagnosing prediabetes will be required to reduce the risk of progressing to diabetes and its complications. The current biomarkers, glycated hemoglobin (HbA1c), fructosamine, and glycated albumin have limitations including moderate sensitivity and specificity and are inaccurate in certain clinical conditions. Therefore, identification of additional biomarkers is being explored recognizing that any single biomarker will also likely have inherent limitations. Therefore, combining several biomarkers may more precisely identify those at high risk for developing prediabetes and subsequent progression to diabetes. This review describes recently identified biomarkers and their potential utility for addressing the burgeoning epidemic of dysglycemic disorders. PMID:28860833

  19. Biomarkers of acute lung injury: worth their salt?

    Directory of Open Access Journals (Sweden)

    Proudfoot Alastair G

    2011-12-01

    Full Text Available Abstract The validation of biomarkers has become a key goal of translational biomedical research. The purpose of this article is to discuss the role of biomarkers in the management of acute lung injury (ALI and related research. Biomarkers should be sensitive and specific indicators of clinically important processes and should change in a relevant timeframe to affect recruitment to trials or clinical management. We do not believe that they necessarily need to reflect pathogenic processes. We critically examined current strategies used to identify biomarkers and which, owing to expedience, have been dominated by reanalysis of blood derived markers from large multicenter Phase 3 studies. Combining new and existing validated biomarkers with physiological and other data may add predictive power and facilitate the development of important aids to research and therapy.

  20. Can Biomarkers Help the Early Diagnosis of Parkinson's Disease?

    Institute of Scientific and Technical Information of China (English)

    Weidong Le; Jie Dong; Song Li; Amos D.Korczyn

    2017-01-01

    Parkinson's disease (PD) is a complex neurodegenerative disease with progressive loss of dopamine neurons.PD patients usually manifest a series of motor and non-motor symptoms.In order to provide better early diagnosis and subsequent disease-modifying therapies for PD patients,there is an urgent need to identify sensitive and specific biomarkers.Biomarkers can be divided into four categories:clinical,imaging,biochemical,and genetic.Ideal biomarkers not only improve our understanding of PD pathogenesis and progression,but also provide benefits for early risk evaluation and clinical diagnosis of PD.Although many efforts have been made and several biomarkers have been extensively investigated,few if any have been found useful for early diagnosis.Here,we summarize recent developments in the discovered biomarkers of PD and discuss their merits and limitations for the early diagnosis of PD.

  1. Possible biomarkers modulating haloperidol efficacy and/or tolerability.

    Science.gov (United States)

    Porcelli, Stefano; Crisafulli, Concetta; Calabrò, Marco; Serretti, Alessandro; Rujescu, Dan

    2016-04-01

    Haloperidol (HP) is widely used in the treatment of several forms of psychosis. Despite of its efficacy, HP use is a cause of concern for the elevated risk of adverse drug reactions. adverse drug reactions risk and HP efficacy greatly vary across subjects, indicating the involvement of several factors in HP mechanism of action. The use of biomarkers that could monitor or even predict HP treatment impact would be of extreme importance. We reviewed the elements that could potentially be used as peripheral biomarkers of HP effectiveness. Although a validated biomarker still does not exist, we underlined the several potential findings (e.g., about cytokines, HP metabolites and genotypic biomarkers) which could pave the way for future research on HP biomarkers.

  2. The New Digital Divide For Digital BioMarkers.

    Science.gov (United States)

    Torous, John; Rodriguez, Jorge; Powell, Adam

    2017-09-01

    As smartphone and sensors continue to become more ubiquitous across the world, digital biomarkers have emerged as a scalable and practical tool to explore disease states and advance health. But as the digital divide of access and ownership begins to fade, a new digital divide is emerging. Who are the types of people that own smartphones or smart watches, who are the types of people that download health apps or partake in digital biomarker studies, and who are the types of people that are actually active with digital biomarkers apps and sensors - the people providing the high quality and longitudinal data that this field is being founded upon? Understanding the people behind digital biomarkers, the very people this emerging field aims to help, may actually be the real challenge as well as opportunity for digital biomarkers.

  3. Target biomarker profile for the clinical management of paracetamol overdose

    Science.gov (United States)

    Vliegenthart, A D Bastiaan; Antoine, Daniel J; Dear, James W

    2015-01-01

    Paracetamol (acetaminophen) overdose is one of the most common causes of acute liver injury in the Western world. To improve patient care and reduce pressure on already stretched health care providers new biomarkers are needed that identify or exclude liver injury soon after an overdose of paracetamol is ingested. This review highlights the current state of paracetamol poisoning management and how novel biomarkers could improve patient care and save healthcare providers money. Based on the widely used concept of defining a target product profile, a target biomarker profile is proposed that identifies desirable and acceptable key properties for a biomarker in development to enable the improved treatment of this patient population. The current biomarker candidates, with improved hepatic specificity and based on the fundamental mechanistic basis of paracetamol-induced liver injury, are reviewed and their performance compared with our target profile. PMID:26076366

  4. Potential Peripheral Biomarkers for the Diagnosis of Alzheimer's Disease

    Directory of Open Access Journals (Sweden)

    Seema Patel

    2011-01-01

    Full Text Available Advances in the discovery of a peripheral biomarker for the diagnosis of Alzheimer's would provide a way to better detect the onset of this debilitating disease in a manner that is both noninvasive and universally available. This paper examines the current approaches that are being used to discover potential biomarker candidates available in the periphery. The search for a peripheral biomarker that could be utilized diagnostically has resulted in an extensive amount of studies that employ several biological approaches, including the assessment of tissues, genomics, proteomics, epigenetics, and metabolomics. Although a definitive biomarker has yet to be confirmed, advances in the understanding of the mechanisms of the disease and major susceptibility factors have been uncovered and reveal promising possibilities for the future discovery of a useful biomarker.

  5. Biomarker assessment and molecular testing for prognostication in breast cancer.

    Science.gov (United States)

    Kos, Zuzana; Dabbs, David J

    2016-01-01

    Current treatment of breast cancer incorporates clinical, pathological and molecular data. Oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) define prognosis and identify tumours for targeted therapy, and remain the sole established single-molecule biomarkers defining the minimum breast cancer pathology data set. Ki67 remains one of the most promising yet controversial biomarkers in breast cancer, implemented routinely in some, but not all, pathology departments. Beyond the single-molecule biomarkers, a host of multigene expression tests have been developed to interrogate the driver pathways and biology of individual breast cancers to predict clinical outcome more accurately. A minority of these assays have entered into clinical practice. This review focuses on the established biomarkers of ER, PR and HER2, the controversial but clinically implemented biomarker Ki67 and the currently marketed gene expression signatures. © 2015 John Wiley & Sons Ltd.

  6. Risk Factors and Biomarkers of Age-Related Macular Degeneration

    Science.gov (United States)

    Lambert, Nathan G.; Singh, Malkit K.; ElShelmani, Hanan; Mansergh, Fiona C.; Wride, Michael A.; Padilla, Maximilian; Keegan, David; Hogg, Ruth E.; Ambati, Balamurali K.

    2016-01-01

    A biomarker can be a substance or structure measured in body parts, fluids or products that can affect or predict disease incidence. As age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, much research and effort has been invested in the identification of different biomarkers to predict disease incidence, identify at risk individuals, elucidate causative pathophysiological etiologies, guide screening, monitoring and treatment parameters, and predict disease outcomes. To date, a host of genetic, environmental, proteomic, and cellular targets have been identified as both risk factors and potential biomarkers for AMD. Despite this, their use has been confined to research settings and has not yet crossed into the clinical arena. A greater understanding of these factors and their use as potential biomarkers for AMD can guide future research and clinical practice. This article will discuss known risk factors and novel, potential biomarkers of AMD in addition to their application in both academic and clinical settings. PMID:27156982

  7. Advances in Biomarkers in Critical Ill Polytrauma Patients.

    Science.gov (United States)

    Papurica, Marius; Rogobete, Alexandru F; Sandesc, Dorel; Dumache, Raluca; Cradigati, Carmen A; Sarandan, Mirela; Nartita, Radu; Popovici, Sonia E; Bedreag, Ovidiu H

    2016-01-01

    The complexity of the cases of critically ill polytrauma patients is given by both the primary, as well as the secondary, post-traumatic injuries. The severe injuries of organ systems, the major biochemical and physiological disequilibrium, and the molecular chaos lead to a high rate of morbidity and mortality in this type of patient. The 'gold goal' in the intensive therapy of such patients resides in the continuous evaluation and monitoring of their clinical status. Moreover, optimizing the therapy based on the expression of certain biomarkers with high specificity and sensitivity is extremely important because of the clinical course of the critically ill polytrauma patient. In this paper we wish to summarize the recent studies of biomarkers useful for the intensive care unit (ICU) physician. For this study the available literature on specific databases such as PubMed and Scopus was thoroughly analyzed. Each article was carefully reviewed and useful information for this study extracted. The keywords used to select the relevant articles were "sepsis biomarker", "traumatic brain injury biomarker" "spinal cord injury biomarker", "inflammation biomarker", "microRNAs biomarker", "trauma biomarker", and "critically ill patients". For this study to be carried out 556 original type articles were analyzed, as well as case reports and reviews. For this review, 89 articles with relevant topics for the present paper were selected. The critically ill polytrauma patient, because of the clinical complexity the case presents with, needs a series of evaluations and specific monitoring. Recent studies show a series of either tissue-specific or circulating biomarkers that are useful in the clinical status evaluation of these patients. The biomarkers existing today, with regard to the critically ill polytrauma patient, can bring a significant contribution to increasing the survival rate, by adapting the therapy according to their expressions. Nevertheless, the necessity remains to

  8. Early biomarkers of joint damage in rheumatoid and psoriatic arthritis.

    LENUS (Irish Health Repository)

    Mc Ardle, Angela

    2015-01-01

    Joint destruction, as evidenced by radiographic findings, is a significant problem for patients suffering from rheumatoid arthritis and psoriatic arthritis. Inherently irreversible and frequently progressive, the process of joint damage begins at and even before the clinical onset of disease. However, rheumatoid and psoriatic arthropathies are heterogeneous in nature and not all patients progress to joint damage. It is therefore important to identify patients susceptible to joint destruction in order to initiate more aggressive treatment as soon as possible and thereby potentially prevent irreversible joint damage. At the same time, the high cost and potential side effects associated with aggressive treatment mean it is also important not to over treat patients and especially those who, even if left untreated, would not progress to joint destruction. It is therefore clear that a protein biomarker signature that could predict joint damage at an early stage would support more informed clinical decisions on the most appropriate treatment regimens for individual patients. Although many candidate biomarkers for rheumatoid and psoriatic arthritis have been reported in the literature, relatively few have reached clinical use and as a consequence the number of prognostic biomarkers used in rheumatology has remained relatively static for several years. It has become evident that a significant challenge in the transition of biomarker candidates to clinical diagnostic assays lies in the development of suitably robust biomarker assays, especially multiplexed assays, and their clinical validation in appropriate patient sample cohorts. Recent developments in mass spectrometry-based targeted quantitative protein measurements have transformed our ability to rapidly develop multiplexed protein biomarker assays. These advances are likely to have a significant impact on the validation of biomarkers in the future. In this review, we have comprehensively compiled a list of candidate

  9. Biomarkers of cadmium and arsenic interactions

    International Nuclear Information System (INIS)

    Nordberg, G.F.; Jin, T.; Hong, F.; Zhang, A.; Buchet, J.P.; Bernard, A.

    2005-01-01

    Advances in proteomics have led to the identification of sensitive urinary biomarkers of renal dysfunction that are increasingly used in toxicology and epidemiology. Recent animal data show that combined exposure to inorganic arsenic (As) and cadmium (Cd) gives rise to more pronounced renal toxicity than exposure to each of the agents alone. In order to examine if similar interaction occurs in humans, renal dysfunction was studied in population groups (619 persons in total) residing in two metal contaminated areas in China: mainly a Cd contaminated area in Zhejiang province (Z-area) and mainly a As contaminated area in Guizhou province (G-area). Nearby control areas without excessive metal exposure were also included. Measurements of urinary β 2 -microglobulin (UB2MG), N-acetyl-β-glucosaminidase (UNAG), retinol binding protein (URBP) and albumin (UALB) were used as markers of renal dysfunction. Urinary Cd (UCd) and total As (UTAs) were analyzed by graphite-furnace atomic absorption spectrometry. Urinary inorganic As and its mono- and di-methylated metabolites (UIAs) were determined by Hydride generation. Results. As expected, the highest UCd values occurred in Z-area (Geometric mean, GM 11.6 μg/g crea) while the highest UTAs values occurred in G-area (GM = 288 μg/g crea). Statistically significant increases compared to the respective control area were present both for UTAs, UCd and for UB2MG, UNAG and UALB in Z-area as well as in G-area. UIAs was determined only in Z area. In G-area, there was a clear dose-response pattern both in relation to UTAs and UCd for each of the biomarkers of renal dysfunction. An interaction effect between As and Cd was demonstrated at higher levels of a combined exposure to As and Cd enhancing the effect on the kidney. In Z-area an increased prevalence of B2MG-uria, NAG-uria and ALB-uria was found in relation to UCd, but no relationship to UTAs was found. A statistically significant relationship between UIAs and UB2MG was found among

  10. Proteomic biomarkers for ovarian cancer risk in women with polycystic ovary syndrome: a systematic review and biomarker database integration.

    Science.gov (United States)

    Galazis, Nicolas; Olaleye, Olalekan; Haoula, Zeina; Layfield, Robert; Atiomo, William

    2012-12-01

    To review and identify possible biomarkers for ovarian cancer (OC) in women with polycystic ovary syndrome (PCOS). Systematic literature searches of MEDLINE, EMBASE, and Cochrane using the search terms "proteomics," "proteomic," and "ovarian cancer" or "ovarian carcinoma." Proteomic biomarkers for OC were then integrated with an updated previously published database of all proteomic biomarkers identified to date in patients with PCOS. Academic department of obstetrics and gynecology in the United Kingdom. A total of 180 women identified in the six studies. Tissue samples from women with OC vs. tissue samples from women without OC. Proteomic biomarkers, proteomic technique used, and methodologic quality score. A panel of six biomarkers was overexpressed both in women with OC and in women with PCOS. These biomarkers include calreticulin, fibrinogen-γ, superoxide dismutase, vimentin, malate dehydrogenase, and lamin B2. These biomarkers could help improve our understanding of the links between PCOS and OC and could potentially be used to identify subgroups of women with PCOS at increased risk of OC. More studies are required to further evaluate the role these biomarkers play in women with PCOS and OC. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  11. An OMIC biomarker detection algorithm TriVote and its application in methylomic biomarker detection.

    Science.gov (United States)

    Xu, Cheng; Liu, Jiamei; Yang, Weifeng; Shu, Yayun; Wei, Zhipeng; Zheng, Weiwei; Feng, Xin; Zhou, Fengfeng

    2018-04-01

    Transcriptomic and methylomic patterns represent two major OMIC data sources impacted by both inheritable genetic information and environmental factors, and have been widely used as disease diagnosis and prognosis biomarkers. Modern transcriptomic and methylomic profiling technologies detect the status of tens of thousands or even millions of probing residues in the human genome, and introduce a major computational challenge for the existing feature selection algorithms. This study proposes a three-step feature selection algorithm, TriVote, to detect a subset of transcriptomic or methylomic residues with highly accurate binary classification performance. TriVote outperforms both filter and wrapper feature selection algorithms with both higher classification accuracy and smaller feature number on 17 transcriptomes and two methylomes. Biological functions of the methylome biomarkers detected by TriVote were discussed for their disease associations. An easy-to-use Python package is also released to facilitate the further applications.

  12. Symptoms and biomarkers associated with celiac disease

    DEFF Research Database (Denmark)

    Kårhus, Line L; Thuesen, Betina H; Rumessen, Juri J.

    2016-01-01

    OBJECTIVES: To identify possible early predictors (symptoms and biomarkers) of celiac disease, compare symptoms before and after screening, and evaluate the diagnostic efficacy of serologic screening for celiac disease in an adult Danish population. METHODS: This cross-sectional population......-positive individuals 19 months after the clinical evaluation to obtain information on their symptoms and their experience with participation in the screening. RESULTS: Before screening, participants subsequently diagnosed with celiac disease did not differ from the rest of the population with respect to symptoms...... with having been diagnosed and 71% felt better on a gluten-free diet. CONCLUSION: There were no differences in the prevalence of symptoms between participants with and without screening-detected celiac disease, confirming that risk stratification in a general population by symptoms is difficult. The majority...

  13. Infectious Disease Proteome Biomarkers: Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, Charles L.

    2011-12-31

    Research for the DOE Infectious Disease Proteome Biomarkers focused on Rift Valley fever virus (RVFV) and Venezuelan Equine Encephalitis Virus (VEEV). RVFV and VEEV are Category A and B pathogens respectively. Among the priority threats, RVFV and VEEV rank high in their potential for being weaponized and introduced to the United States, spreading quickly, and having a large health and economic impact. In addition, they both have live attenuated vaccine, which allows work to be performed at BSL-2. While the molecular biology of RVFV and VEEV are increasingly well-characterized, little is known about its host-pathogen interactions. Our research is aimed at determining critical alterations in host signaling pathways to identify therapeutics targeted against the host.

  14. Exosome: emerging biomarker in breast cancer

    Science.gov (United States)

    Jia, Yunlu; Chen, Yongxia; Wang, Qinchuan; Jayasinghe, Ushani; Luo, Xiao; Wei, Qun; Wang, Ji; Xiong, Hanchu; Chen, Cong; Xu, Bin; Hu, Wenxian; Wang, Linbo; Zhao, Wenhe; Zhou, Jichun

    2017-01-01

    Exosomes are nano-sized membrane vesicles released by a variety of cell types, and are thought to play important roles in intercellular communications. In breast cancer, through horizontal transfer of various bioactive molecules, such as proteins and mRNAs, exosomes are emerging as local and systemic cell-to-cell mediators of oncogenic information and play an important role on cancer progression. This review outlines the current knowledge and concepts concerning the exosomes involvement in breast cancer pathogenesis (including tumor initiation, invasion and metastasis, angiogenesis, immune system modulation and tumor microenvironment) and cancer therapy resistance. Moreover, the potential use of exosomes as promising diagnostic and therapeutic biomarkers in breast cancer are also discussed. PMID:28402944

  15. Apolipoprotein M - a new biomarker in sepsis

    DEFF Research Database (Denmark)

    Christoffersen, Christina; Nielsen, Lars Bo

    2012-01-01

    Care Kumaraswamy and colleagues have investigated whether plasma apolipoprotein M (apoM) is affected during different grades of sepsis, septic shock and systemic inflammatory response syndrome. Interestingly, plasma apoM was significantly decreased in all groups of patients with a relationship...... to severity of disease. This identifies apoM as a potential new biomarker in sepsis. It also underscores the possibility that altered high-density lipoprotein in sepsis patients can affect the course of disease. Thus, since apoM is the carrier of Sphingosine-1-P (S1P), a molecule with great influence...... on vascular barrier function, the study presented raises the interest and relevance for further studies of apoM and S1P in relation to sepsis and inflammation....

  16. Biomarker Gene Signature Discovery Integrating Network Knowledge

    Directory of Open Access Journals (Sweden)

    Holger Fröhlich

    2012-02-01

    Full Text Available Discovery of prognostic and diagnostic biomarker gene signatures for diseases, such as cancer, is seen as a major step towards a better personalized medicine. During the last decade various methods, mainly coming from the machine learning or statistical domain, have been proposed for that purpose. However, one important obstacle for making gene signatures a standard tool in clinical diagnosis is the typical low reproducibility of these signatures combined with the difficulty to achieve a clear biological interpretation. For that purpose in the last years there has been a growing interest in approaches that try to integrate information from molecular interaction networks. Here we review the current state of research in this field by giving an overview about so-far proposed approaches.

  17. Biomarkers to monitor drug-induced phospholipidosis

    International Nuclear Information System (INIS)

    Baronas, Elizabeth Tengstrand; Lee, Ju-Whei; Alden, Carl; Hsieh, Frank Y.

    2007-01-01

    Di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate (BMP) was identified as a promising phospholipidosis (PL) biomarker in rats treated with either amiodarone, gentamicin, or azithromycin. Sprague-Dawley rats received either amiodarone (150 mg/kg), gentamicin (100 mg/kg) or azithromycin (30 mg/kg) once daily for ten consecutive days. Histopathological examination of tissues by transmission electron microscopy (TEM) indicated different degrees of accumulation of phospholipidosis in liver, lung, mesenteric lymph node, and kidney of drug-treated rats but not controls. Liquid chromatography coupled to mass spectrometry (LC/MS) was used to identify levels of endogenous biochemical profiles in rat urine. Urinary levels of di-docosahexaenoyl (C22:6)-bis(monoacylglycerol) phosphate (BMP) correlated with induction of phospholipidosis for amiodarone, gentamicin and azithromycin. Rats treated with gentamicin also had increased urinary levels of several phosphatidylinositol (PI), phosphatidylcholine (PC), and phosphatidylethanolamine (PE) species

  18. Clinical Relevance of Biomarkers of Oxidative Stress

    DEFF Research Database (Denmark)

    Frijhoff, Jeroen; Winyard, Paul G; Zarkovic, Neven

    2015-01-01

    SIGNIFICANCE: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino ac....... The vast diversity in oxidative stress between diseases and conditions has to be taken into account when selecting the most appropriate biomarker.......SIGNIFICANCE: Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation of DNA to proteins, lipids, and free amino...... acids. RECENT ADVANCES: An increased understanding of the biology behind diseases and redox biology has led to more specific and sensitive tools to measure oxidative stress markers, which are very diverse and sometimes very low in abundance. CRITICAL ISSUES: The literature is very heterogeneous...

  19. Biomarkers of postoperative delirium and cognitive dysfunction

    Directory of Open Access Journals (Sweden)

    Ganna eAndrosova

    2015-06-01

    Full Text Available Elderly surgical patients frequently experience postoperative delirium (POD and the subsequent development of postoperative cognitive dysfunction (POCD. Clinical features include deterioration in cognition, disturbance in attention and reduced awareness of the environment and result in higher morbidity, mortality and greater utilization of social financial assistance. The aging Western societies can expect an increase in the incidence of POD and POCD. The underlying pathophysiological mechanisms have been studied on the molecular level albeit with unsatisfying small research efforts given their societal burden. Here, we review the known physiological and immunological changes and genetic risk factors, identify candidates for further studies and integrate the information into a draft network for exploration on a systems level. The pathogenesis of these postoperative cognitive impairments is multifactorial; application of integrated systems biology has the potential to reconstruct the underlying network of molecular mechanisms and help in the identification of prognostic and diagnostic biomarkers.

  20. FET-biosensor for cardiac troponin biomarker

    Directory of Open Access Journals (Sweden)

    Md Arshad Mohd Khairuddin

    2017-01-01

    Full Text Available Acute myocardial infarction or myocardial infarction (MI is a major health problem, due to diminished flow of blood to the heart, leads to higher rates of mortality and morbidity. The most specific markers for cardiac injury are cardiac troponin I (cTnI and cardiac troponin T (cTnT which have been considered as ‘gold standard’. Due to higher specificity, determination of the level of cardiac troponins became a predominant indicator for MI. Currently, field-effect transistor (FET-based biosensors have been main interest to be implemented in portable sensors with the ultimate application in point-of-care testing (POCT. In this paper, we review on the FET-based biosensor based on its principle of operation, integration with nanomaterial, surface functionalization as well as immobilization, and the introduction of additional gate (for ambipolar conduction on the device architecture for the detection of cardiac troponin I (cTnI biomarker.

  1. The COPD Biomarker Qualification Consortium (CBQC)

    DEFF Research Database (Denmark)

    Casaburi, Richard; Celli, Bartolome; Crapo, James

    2013-01-01

    Abstract Knowledge about the pathogenesis and pathophysiology of chronic obstructive pulmonary disease (COPD) has advanced dramatically over the last 30 years. Unfortunately, this has had little impact in terms of new treatments. Over the same time frame, only one new class of medication for COPD......, and no interested party has been in a position to undertake such a process. In order to facilitate the development of novel tools to assess new treatments, the Food and Drug Administration, in collaboration with the COPD Foundation, the National Heart Lung and Blood Institute and scientists from the pharmaceutical...... industry and academia conducted a workshop to survey the available information that could contribute to new tools. Based on this, a collaborative project, the COPD Biomarkers Qualification Consortium, was initiated. The Consortium in now actively preparing integrated data sets from existing resources...

  2. Perfil epidemiológico de mulheres atendidas na consulta do pré-natal de um hospital universitário Perfil epidemiológico de mujeres atendidas en consulta prenatal de un hospital universitario Epidemiological profile of consulting women at the prenatal service of a university hospital

    Directory of Open Access Journals (Sweden)

    Thelma Spindola

    2006-09-01

    Full Text Available Trata-se de um estudo descritivo em abordagem quantitativa tendo como objeto as gestantes atendidas na consulta de pré-natal e o objetivo de identificar esta clientela traçando seu perfil epidemiológico. O Ambulatório de Obstetrícia de um Hospital público do município do Rio de Janeiro foi o cenário, onde foram investigadas 118 fichas de atendimento cadastradas de janeiro a junho de 2003. A análise dos resultados evidenciou que a maioria das mulheres estudadas concentra-se na faixa etária de 19 - 25 anos (39,8%; casadas (38,9%; com ensino fundamental (29,6%; ocupação do lar (33,8%; multíparas (58,4%; iniciaram o pré-natal com idade gestacional entre 14 e 17 semanas (18,6%; tiveram anteriormente partos vaginais (79 e não referiram queixas na primeira consulta (39%. Podemos concluir que o atendimento obstétrico contribui de maneira significativa para a redução da morbi-mortalidade das gestantes, possibilitando a orientação de intercorrências no ciclo grávido-puerperal e a prevenção de complicações.Se trata de un estudio descriptivo con abordaje cuantitativo tenien-do como objeto a gestantes atendidas en consulta prenatal y el objetivo de identificar a esta clientela trazando su perfil epidemiológico. El escenario fue el consul-torio externo de obstetricia de un Hospital público del municipio de Rio de Janeiro, donde fueron investigadas 118 fichas de atención registradas de enero a junio del 2003. El análisis de los resultados evidenció que la mayoría de las mujeres estudiadas se concentra en el grupo etáreo de 19 - 25 años (39,8%; casadas (38,9%; con enseñaza fundamental (29,6%; amas de casa (33,8%; multíparas (58,4%; iniciaron el prenatal con edad gestacional entre 14 y 17 semanas (18,6%; tuvieron anteriormente partos vaginales (79% y no refirieron quejas en la primera consulta (39%. Podemos concluir que la atención obstétrica contribuye de manera significativa en la reducción de la morbimortalidad de las

  3. Queimaduras em crianças e adolescentes: caracterização clínica e epidemiológica Quemaduras en niños y adolescentes: caracterización clínica y epidemiológica Burn injuries in children and adolescents: clinical and epidemiological characterization

    Directory of Open Access Journals (Sweden)

    Fernanda Maria Félix de Alencar Fernandes

    2012-12-01

    Full Text Available As queimaduras constituem importantes causas de morbimortalidade infanto-juvenil, cujas repercussões refletem em significativas limitações funcionais. Trata-se de um estudo descritivo, de natureza quantitativa, que objetivou caracterizar o perfil clínico-epidemiológico de crianças e adolescentes vítimas de queimaduras admitidas em um Hospital de Referência de João Pessoa, Brasil, de janeiro de 2007 a dezembro de 2009. A maioria das vítimas compõe-se de lactentes (37%, pré-escolares (33,2% e do gênero masculino (54%. Os eventos ocorreram, principalmente, no domicílio (85,5%, acidentalmente (90% e por escaldamento (69,6%. Predominaram as queimaduras de 2º grau, em 62,6% dos casos, e cerca de 24,2% da amostra evoluíram com complicações secundárias, sendo a infecção a mais comum (12,1%. A balneoterapia foi um dos procedimentos mais realizados. Conclui-se a necessidade em intensificar programas educativos nas escolas, nos centros comunitários e meios de comunicação, já que grande parte dos acidentes ocorreu no ambiente doméstico, podendo ser evitados.Las quemaduras constituyen importantes causas de morbimortalidad infanto-juvenil cuyas repercusiones reflejan en significativas limitaciones funcionales. Se trata de un estudio descriptivo, de naturaleza cuantitativa que objetivó caracterizar el perfil clínico-epidemiológico de niños y adolescentes víctimas de quemaduras admitidas en un Hospital de Referencia de João Pessoa, Brasil, de enero del 2007 a diciembre del 2009. La mayoría de las víctimas fue lactante (37%, preescolar (33,2% y de género masculino (54%. Los eventos ocurrieron principalmente en el domicilio (85,5%, accidentalmente (90% y por escaldamiento (69,6%. Predominaron las quemaduras de 2º grado en 62,6% de los casos y cerca del 24,2% de la muestra evolucionaron con complicaciones secundarias, siendo la infección la más común (12,1%. La balneoterapia es uno de los procedimientos más realizados. Se

  4. Revisão sistemática dos estudos epidemiológicos sobre discriminação interpessoal e saúde mental Revisión sistemática de estudios epidemiológicos sobre la discriminación interpersonal y salud mental Systematic review of epidemiological studies on interpersonal discrimination and mental health

    Directory of Open Access Journals (Sweden)

    Paulo Francisco Mastella Couto

    2013-03-01

    Full Text Available Foram caracterizados estudos epidemiológicos que avaliaram a relação entre discriminação interpessoal e condições de saúde mental, atualizando revisões prévias sobre o tema. Identificaram-se 34 artigos publicados entre 2000 e 2010 no PubMed, dos quais 68% utilizaram amostras de conveniência e 82% o delineamento transversal. Observaram-se associações positivas e estatisticamente significativas entre discriminação e condições adversas de saúde mental, especialmente uso de substâncias, depressão e transtornos associados ao uso de álcool. Somente um terço dos estudos explicitou um referencial teórico para interpretar as relações examinadas. Similarmente às revisões anteriores, pode-se afirmar que as experiências discriminatórias se associam positiva e consistentemente com desfechos adversos de saúde mental. Entretanto, investigações futuras deverão empregar delineamentos mais robustos para a inferência causal, utilizar instrumentos de discriminação com boas propriedades psicométricas e adotar referencial teórico específico para interpretar os resultados produzidos.Fueron caracterizados los estudios epidemiológicos que evaluaron la relación entre la discriminación interpersonal y salud mental, actualizando revisiones previas sobre el tema. Se identificaron 34 artículos publicados entre 2000 y 2010 a través del PubMed, de los cuales el 68% utilizaron muestras de conveniencia y el 82% fueron estudios transversales. Se observaron asociaciones positivas y estadísticamente significativas entre la discriminación y condiciones adversas de salud mental, especialmente consumo de substancias, depresión y los trastornos asociados al consumo de alcohol. Sólo un tercio de los estudios explicitó un marco teórico para interpretar las relaciones examinadas. Al igual que en las revisiones anteriores, se puede afirmar que las experiencias discriminatorias se asocian positiva y consistentemente con resultados adversos

  5. Características epidemiológicas dos óbitos maternos ocorridos em Recife, PE, Brasil (2000-2006 Caracteristicas epidemiológicas de las muertes maternas ocurridas en Recife, PE, Brasil (2000-2006 Epidemiological features of maternal deaths occurred in Recife, PE, Brazil (2000-2006

    Directory of Open Access Journals (Sweden)

    Rafaella Araújo Correia

    2011-02-01

    Full Text Available Estudo de corte transversal que objetivou descrever as características epidemiológicas dos óbitos maternos de residentes no Recife, PE, Brasil, ocorridos entre 2000 e 2006. A fonte de dados foi constituída pelas fichas de investigação de óbito materno da Secretaria de Saúde do Recife. Para a análise dos dados, utilizou-se o programa EpiInfo 6.04d. Foram estudados 111 óbitos, correspondendo a uma Razão de Morte Materna de 65,99/100.000 nascidos vivos. Os dados obstétricos mostraram a realização de menos de seis consultas pré-natais, entre uma e quatro gestações prévias, parto cesário e admissão em estado grave. Os transtornos hipertensivos constituíram a principal causa de óbito. A maioria dos óbitos foi considerada evitável. Os resultados indicam a necessidade de aprimorar a assistência à saúde da gestante durante o pré-natal, parto e puerpérioEstudio de corte transversal cuyo objetivo ha sido describir las características epidemiológicas de los óbitos maternos de residentes en la ciudad de Recife, PE, Brasil ocurridos entre los años 2000 y 2006. La fuente de datos la constituyeron las fichas de investigación de óbito materna de la Secretaría de Salud de Recife. Para el análisis de los datos se ha hecho uso del programa EpiInfo 6.04d. Han sido investigados 111 óbitos, lo que corresponde a una Razón de Muerte Materna de 65,99/100.000 nacidos vivos. Los datos obstétricos han demostrado la realización de menos de seis consultas prenatales, entre una y cuatro gestaciones previas, parto cesáreo, ingreso en estado grave, con demanda de asistencia bajo terapia. Los trastornos hipertensivos constituyeron la principal causa del óbito. En su mayor parte, los óbitos han sido considerados evitables. Los resultados señalan la necesidad de aprimorar la asistencia a la salud de la gestante en el período prenatal, el parto y el puerperioThis was a cross-sectional study that aimed to describe the epidemiological

  6. Metabolic Imaging Biomarkers of Postradiotherapy Xerostomia

    Energy Technology Data Exchange (ETDEWEB)

    Cannon, Blake [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Schwartz, David L., E-mail: dschwartz3@nshs.edu [Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States); Department of Radiation Medicine, Hofstra North Shore-LIJ School of Medicine, New Hyde Park, New York (United States); Feinstein Institute for Medical Research, Manhasset, New York (United States); Dong Lei [Department of Radiation Physics, University of Texas M. D. Anderson Cancer Center, Houston, Texas (United States)

    2012-08-01

    Purpose: Xerostomia is a major complication of head and neck radiotherapy (RT). Available xerostomia measures remain flawed. [{sup 18}F]fluorodeoxyglucose-labeled positron emission tomography-computed tomography (FDG-PET-CT) is routinely used for staging and response assessment of head and neck cancer. We investigated quantitative measurement of parotid gland FDG uptake as a potential biomarker for post-RT xerostomia. Methods and Materials: Ninety-eight locally advanced head and neck cancer patients receiving definitive RT underwent baseline and post-RT FDG-PET-CT on a prospective imaging trial. A separate validation cohort of 14 patients underwent identical imaging while prospectively enrolled in a second trial collecting sialometry and patient-reported outcomes. Radiation dose and pre- and post-RT standard uptake values (SUVs) for all voxels contained within parotid gland ROI were deformably registered. Results: Average whole-gland or voxel-by-voxel models incorporating parotid D{sub Met} (defined as the pretreatment parotid SUV weighted by dose) accurately predicted posttreatment changes in parotid FDG uptake (e.g., fractional parotid SUV). Fractional loss of parotid FDG uptake closely paralleled early parotid toxicity defined by posttreatment salivary output (p < 0.01) and Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer xerostomia scores (p < 0.01). Conclusions: In this pilot series, loss of parotid FDG uptake was strongly associated with acute clinical post-RT parotid toxicity. D{sub Met} may potentially be used to guide function-sparing treatment planning. Prospective validation of FDG-PET-CT as a convenient, quantifiable imaging biomarker of parotid function is warranted and ongoing.

  7. [Mixed depressions: clinical and neurophysiological biomarkers].

    Science.gov (United States)

    Micoulaud Franchi, J-A; Geoffroy, P-A; Vion-Dury, J; Balzani, C; Belzeaux, R; Maurel, M; Cermolacce, M; Fakra, E; Azorin, J-M

    2013-12-01

    Epidemiological studies of major depressive episodes (MDE) highlighted the frequent association of symptoms or signs of mania or hypomania with depressive syndrome. Beyond the strict definition of DSM-IV, epidemiological recognition of a subset of MDE characterized by the presence of symptoms or signs of the opposite polarity is clinically important because it is associated with pejorative prognosis and therapeutic response compared to the subgroup of "typical MDE". The development of DSM-5 took into account the epidemiological data. DSM-5 opted for a more dimensional perspective in implementing the concept of "mixed features" from an "episode" to a "specification" of mood disorder. As outlined in the DSM-5: "Mixed features associated with a major depressive episode have been found to be a significant risk factor for the development of bipolar I and II disorder. As a result, it is clinically useful to note the presence of this specifier for treatment planning and monitoring of response to therapeutic". However, the mixed features are sometimes difficult to identify, and neurophysiological biomarkers would be useful to make a more specific diagnosis. Two neurophysiological models make it possible to better understand MDE with mixed features : i) the emotional regulation model that highlights a tendency to hyper-reactive and unstable emotion response, and ii) the vigilance regulation model that highlights, through EEG recording, a tendency to unstable vigilance. Further research is required to better understand relationships between these two models. These models provide the opportunity of a neurophysiological framework to better understand the mixed features associated with MDE and to identify potential neurophysiological biomarkers to guide therapeutic strategies. Copyright © 2013 L’Encéphale. Published by Elsevier Masson SAS.. All rights reserved.

  8. Cancer biomarker discovery: the entropic hallmark.

    Science.gov (United States)

    Berretta, Regina; Moscato, Pablo

    2010-08-18

    It is a commonly accepted belief that cancer cells modify their transcriptional state during the progression of the disease. We propose that the progression of cancer cells towards malignant phenotypes can be efficiently tracked using high-throughput technologies that follow the gradual changes observed in the gene expression profiles by employing Shannon's mathematical theory of communication. Methods based on Information Theory can then quantify the divergence of cancer cells' transcriptional profiles from those of normally appearing cells of the originating tissues. The relevance of the proposed methods can be evaluated using microarray datasets available in the public domain but the method is in principle applicable to other high-throughput methods. Using melanoma and prostate cancer datasets we illustrate how it is possible to employ Shannon Entropy and the Jensen-Shannon divergence to trace the transcriptional changes progression of the disease. We establish how the variations of these two measures correlate with established biomarkers of cancer progression. The Information Theory measures allow us to identify novel biomarkers for both progressive and relatively more sudden transcriptional changes leading to malignant phenotypes. At the same time, the methodology was able to validate a large number of genes and processes that seem to be implicated in the progression of melanoma and prostate cancer. We thus present a quantitative guiding rule, a new unifying hallmark of cancer: the cancer cell's transcriptome changes lead to measurable observed transitions of Normalized Shannon Entropy values (as measured by high-throughput technologies). At the same time, tumor cells increment their divergence from the normal tissue profile increasing their disorder via creation of states that we might not directly measure. This unifying hallmark allows, via the the Jensen-Shannon divergence, to identify the arrow of time of the processes from the gene expression profiles

  9. DNA Methylation as a Biomarker for Preeclampsia

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Cindy M.; Ralph, Jody L.; Wright, Michelle L.; Linggi, Bryan E.; Ohm, Joyce E.

    2014-10-01

    Background: Preeclampsia contributes significantly to pregnancy-associated morbidity and mortality as well as future risk of cardiovascular disease in mother and offspring, and preeclampsia in offspring. The lack of reliable methods for early detection limits the opportunities for prevention, diagnosis, and timely treatment. Purpose: The purpose of this study was to explore distinct DNA methylation patterns associated with preeclampsia in both maternal cells and fetal-derived tissue that represent potential biomarkers to predict future preeclampsia and inheritance in children. Method: A convenience sample of nulliparous women (N = 55) in the first trimester of pregnancy was recruited for this prospective study. Genome-wide DNA methylation was quantified in first-trimester maternal peripheral white blood cells and placental chorionic tissue from normotensive women and those with preeclampsia (n = 6/group). Results: Late-onset preeclampsia developed in 12.7% of women. Significant differences in DNA methylation were identified in 207 individual linked cytosine and guanine (CpG) sites in maternal white blood cells collected in the first trimester (132 sites with gain and 75 sites with loss of methylation), which were common to approximately 75% of the differentially methylated CpG sites identified in chorionic tissue of fetal origin. Conclusion: This study is the first to identify maternal epigenetic targets and common targets in fetal-derived tissue that represent putative biomarkers for early detection and heritable risk of preeclampsia. Findings may pave the way for diagnosis of preeclampsia prior to its clinical presentation and acute damaging effects, and the potential for prevention of the detrimental long-term sequelae.

  10. Procalcitonin as an adjunctive biomarker in sepsis

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    Mahua Sinha

    2011-01-01

    Full Text Available Sepsis can sometimes be difficult to substantiate, and its distinction from non-infectious conditions in critically ill patients is often a challenge. Serum procalcitonin (PCT assay is one of the biomarkers of sepsis. The present study was aimed to assess the usefulness of PCT assay in critically ill patients with suspected sepsis. The study included 40 patients from the intensive care unit with suspected sepsis. Sepsis was confirmed clinically and/or by positive blood culture. Serum PCT was assayed semi-quantitatively by rapid immunochromatographic technique (within 2 hours of sample receipt. Among 40 critically ill patients, 21 had clinically confirmed sepsis. There were 12 patients with serum PCT ≥10 ng/ml (8, blood culture positive; 1, rickettsia; 2, post-antibiotic blood culture sterile; and 1, non-sepsis; 7 patients with PCT 2-10 ng/ml (4, blood culture positive; 1, falciparum malaria; 2, post-antibiotic blood culture sterile; 3 patients with PCT of 0.5 to 2 ng/ml (sepsis in 1 patient; and 18 patients with PCT < 0.5 ng/ml (sepsis in 2 patients. Patients with PCT ≥ 2 ng/ml had statistically significant correlation with the presence of sepsis (P<0.0001. The PCT assay revealed moderate sensitivity (86% and high specificity (95% at a cut-off ≥ 2 ng/ml. The PCT assay was found to be a useful biomarker of sepsis in this study. The assay could be performed and reported rapidly and provided valuable information before availability of culture results. This might assist in avoiding unwarranted antibiotic usage.

  11. Aspectos radiológicos e epidemiológicos do granuloma central de células gigantes Radiological and epidemiological aspects of central giant cell granuloma

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    José Wilson Noleto

    2007-06-01

    Full Text Available OBJETIVO: Este estudo teve como objetivo avaliar os principais aspectos radiográficos e epidemiológicos das lesões de células gigantes (granulomas centrais de células gigantes e tumores marrons do hiperparatireoidismo. MATERIAIS E MÉTODOS: A amostra consistiu de 26 lesões de células gigantes diagnosticadas em 22 pacientes divididos em dois grupos, um deles composto por 17 pacientes que não tinham hiperparatireoidismo (grupo A e o outro formado por cinco pacientes portadores de tal distúrbio (grupo B. RESULTADOS: O sexo feminino (72,7% foi o mais acometido. As lesões ocorreram mais freqüentemente na segunda década de vida, com média de idade de 27 anos. A mandíbula (61,5% foi o arco mais envolvido. Radiograficamente, 57,7% das lesões eram multiloculares e 42,3% eram uniloculares com limites definidos. Todas as 26 lesões provocaram expansão óssea, 15,4% produziram reabsorção radicular, 50% causaram deslocamento dentário e 11,5% produziram dor. Na mandíbula, 18,7% das lesões cruzavam a linha média. O grupo A apresentou 66,7% das lesões na mandíbula e o grupo B mostrou igualdade na distribuição das lesões entre os arcos. O grupo A apresentou 66,7% das lesões multiloculares e 33,3%, uniloculares. O grupo B apresentou 62,5% das lesões uniloculares e 37,5%, multiloculares. CONCLUSÃO: As lesões de células gigantes podem manifestar-se, radiograficamente, com um amplo espectro, desde pequenas lesões uniloculares de crescimento lento até extensas lesões multiloculares. Elas apresentam características de benignidade, embora algumas lesões possam demonstrar um comportamento localmente agressivo.OBJECTIVE: The present study was aimed at evaluating main radiological and epidemiological aspects of giant cell lesions (central giant cell granuloma and brown tumors of hyperparathyroidism. MATERIALS AND METHODS: The sample consisted of 26 giant cell lesions diagnosed in 22 patients divided into two groups, one of them

  12. Alguns pilares para a apreciação da validade de estudos epidemiológicos Pillars for assessing validity in epidemiological studies

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    Michael E. Reichenheim

    1998-08-01

    Full Text Available Abordagem da questão da validade dos estudos epidemiológicos. Distinguem-se seis tipos de validade. Na validade conceitual enfocam-se os elementos que sustentam a construção de um modelo teórico explicativo do fenômeno de interesse, articulado no plano do discurso e conceitos abstratos. Na validade operacional discutem-se os processos nos quais os conceitos que compõem as diferentes dimensões do modelo teórico são reduzidos a variáveis e indicadores, viabilizando sua instrumentação no nível empírico. À apresentação da validade de domínio, levanta-se a questão da intercambialidade dos indivíduos da população alvo e da população de estudo como sustentação para a generalização dos resultados. A validade de comparação dos grupos de estudo gira em torno da identificação das circunstâncias que rompem a estrutura de comparabilidade, a saber, a situação de confusão e a exclusão seletiva de elementos. À abordagem da validade de informação, aprofundam-se os problemas referentes à aferição/mensuração e os conseqüentes viéses. Visando algumas diretrizes para avaliação da validade de informação, explora-se os fundamentos das relações temporais envolvendo as ocorrências e os processos de coleta. Por fim, apresentam-se algumas importantes questões relacionadas à escolha e validade de especificação do modelo estatístico, bem como comentários sobre as estratégias mais utilizadas na seleção de variáveis e diagnóstico de modelo. Na parte final, sustenta-se que um enfrentamento sistemático das questões de validade pode servir como um dos pilares para a construção do conhecimento em epidemiologia.The article outlines several validity issues in epidemiological studies. Six types of validity are covered. Conceptual validity concerns the elements sustaining a theoretical explanatory model, which, by definition, exists only on an abstract and discursive level. Operational validity concerns the

  13. Avaliação da Vigilância Epidemiológica em âmbito municipal Evaluation of epidemiological surveillance in municipal ambit

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    Eduardo Freese de Carvalho

    2005-12-01

    Full Text Available OBJETIVOS: avaliar a vigilância epidemiológica (VE e as características específicas da gestão municipal. MÉTODOS: foram selecionados onze municípios de Pernambuco conforme critérios geográficos, porte populacional e condição de gestão. O grau de implantação foi estimado através de entrevistas com atores-chave em três níveis de atuação da VE: nível central, unidades de saúde da família (USF e unidades de saúde tradicionais (UST, enfatizando aspectos relativos à infra-estrutura e ao processo de trabalho. Às variáveis selecionadas foram atribuídos pontos, cujo somatório, classificou a VE como: implantada, parcialmente implantada e não implantada. Para avaliar as características da gestão foram entrevistados os onze secretários municipais de saúde. RESULTADOS: a VE apresentou-se implantada em apenas 27% dos municípios e parcialmente implantada em 46%, encontrando-se mais estruturada nos municípios de grande porte e com gestão plena do sistema municipal, onde, dos três níveis estudados, observou-se que o nível central apresentou mais fragilidades, e as USF, quando comparadas às UST, obtiveram melhor desempenho. Quanto às características de gestão, embora todos os municípios estivessem certificados para realizar ações de VE, foram identificados entraves significativos para sua efetiva realização. CONCLUSÕES: A VE apresentou deficiências que comprometem a sua implantação plena no âmbito municipal.ABSTRACT OBJECTIVES: to evaluate epidemiological surveil-lance (ES and its specifics management at municipal level. METHODS: eleven municipalities were selected in the State of Pernambuco, Brazil, based on the geographical, demographic and management criteria. The level of implementation was estimated by way of interviews with key-players at three levels of ES: the headquarters, family health units (FHUs and traditional health units (THUs, laying emphasis on features relating to infrastructure and the work

  14. Comportamiento clínico y epidemiológico del cáncer de cavidad oral Clinical and epidemiologic behavior of oral cancer

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    Alexis Peña González

    2006-04-01

    Full Text Available Se realizó un estudio descriptivo en el Hospital Oncológico Provincial Docente “María Curie” para caracterizar clínica y epidemiológicamente el cáncer de la cavidad bucal desde el año 1999 hasta el 2004. Se estudiaron 79 pacientes de un universo de 285 y se excluyeron 206 pacientes con cáncer del labio. Se analizaron las variables grupos de edades, sexo, factores de riesgo, manifestaciones clínicas, localización anatómica, tipo histológico, forma clínica, estadio clínico y modalidad terapéutica. El procesamiento estadístico se realizó mediante estadística descriptiva, tablas de contingencia y gráficos; como medida de resumen se utilizó el porcentaje y el test de proporción. Predominó la enfermedad en pacientes de 70-79 años con 24 (30,38 %, y el sexo masculino, con 59 pacientes (74,68 %. El tabaquismo se detectó en 38 de estos (48,10 %, de los cuales 35 (44,30 % refirieron dolor como principal síntoma. El carcinoma epidermoide fue la variedad histológica más frecuente (76, para el 96,20 %. Su localización prevaleció en la lengua (24 casos, para el 30,38 %. El diagnóstico frecuentemente se realizó en un estadio III (en 42 pacientes, para el 53,16 % y predominó la forma clínica mixta (38 para el 48,10 %. La radioterapia fue el tratamiento más utilizado en sus diferentes variantes con 64 casos (81,0 %.A descriptive study was conducted in “Maria Curie” Oncological Provincial Teaching Hospital in order to characterize oral cancer from the clinical and epidemiologic point of view between 1999 and 2004. 79 patients of a total of 285 were studied and 206 with lip cancer were excluded. Variables such as age groups, sex, risk factors, clinical manifestations, anatomical localization, histological type, clinical form, clinical stage and therapeutical modality were analyzed. The statistical processing was carried out by descriptive statistics, contingency tables and graphs. Percentage and proportion test were used

  15. Aspectos epidemiológicos, clínicos e anatomopatológicos do linfoma em bovinos: 128 casos (1965-2013

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    Welden Panziera

    2014-09-01

    Full Text Available Por meio de um estudo retrospectivo, os aspectos epidemiológicos, clínicos e anatomopatológicos de 128 casos de linfoma bovino são descritos. Dos protocolos que informavam o sexo (n=111, 84,7% correspondiam a fêmeas e 15,3% a machos. Dos protocolos em que constava a raça (n=108, a mais prevalente foi a holandesa (63%. Em relação à idade (n=107, houve uma variação entre um e 14 anos. A maioria dos bovinos era adulta (89,7% e a maior concentração dos casos ocorreu ao redor de 5-8 anos (57,9%. Em relação aos sinais clínicos (n=89, linfadenomegalia foi o achado mais frequentemente observado (74,1%. Outros sinais clínicos, principalmente aqueles relacionados com os sistemas respiratório (dispneia, estertoração pulmonar e taquipneia, cardiovascular (taquicardia, edema subcutâneo e pulso venoso positivo, digestório (atonia ruminal, timpanismo e diarreia e nervoso (paresia dos membros pélvicos e andar cambaleante, foram pouco prevalentes. Na necropsia (n=125, 71,2% dos bovinos apresentavam aumento de volume dos linfonodos; essa linfadenomegalia foi classificada como localizada em 89,6% dos casos e generalizada em 10,3% dos casos. Dos protocolos que informavam os linfonodos acometidos (n=58, a distribuição foi a seguinte: mesentéricos (51,7%, mediastínicos (37,9%, pré-escapulares (29,3%, ilíacos internos (27,6%, inguinais superficiais (25,8% e traqueobrônquicos (18,9%. Além dos linfonodos, outros órgãos comumente afetados pelo linfoma neste estudo incluíram: coração (40%, fígado (15,2%, rim (14,4%, abomaso (12,8%, útero (11,2%, intestino (10,4% e pulmão (7,2%. A presença de massas tumorais no canal vertebral foi observada em poucos casos (3,2%. Com base na epidemiologia e na localização das lesões, a maioria dos casos (96% foi classificada como linfoma enzoótico e o restante (4% como linfoma esporádico. Os resultados encontrados neste estudo irão auxiliar clínicos de grandes animais e patologistas veterin

  16. Representaciones sociales sobre dengue en docentes de Argentina en dos contextos epidemiológicos: aportes para la formación docente

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    Fernando Garelli

    2017-01-01

    Full Text Available Entendemos al dengue como una problemática compleja de salud socioambiental. Considerada la enfermedad viral transmitida por artrópodos de mayor importancia en el mundo, se ha instalado en la Argentina con gran significatividad social y epidemiológica, especialmente en periodos epidémicos. Durante este año, 2016, oficialmente se registraron alrededor de 40.000 casos (la mayor cantidad de la historia y la problemática tuvo un intenso tratamiento en los medios de comunicación. En el marco de un abordaje de la problemática desde la investigación educativa, basándonos en información empírica obtenida en talleres de formación, realizamos un análisis de representaciones sociales de docentes de primaria. Los procesos de formación docente fueron implementados en dos provincias de Argentina, una con baja incidencia de casos y otra con altos niveles de transmisión. En los resultados identificamos un patrón común, constituido por un sesgo inicial hacia la dimensión biomédica, siendo el mosquito y los síntomas, entre otras, las primeras imágenes más fuertemente asociadas al dengue. Esto resultó un punto de partida a partir del cual, luego del trabajo grupal en los talleres, emergieron con más fuerza otras dimensiones, destacándose particularmente la política y, en menor medida, la sociocultural, relacionada con la información y su circulación social. Finalmente, en las actividades elaboradas para desarrollar en los contextos educativos de cada docente, identificamos una gran frecuencia de propuestas vinculadas principalmente con la difusión en las que solamente aparecían las dimensiones biomédica y sociocultural, prácticamente con igual peso. Así, el contenido de las representaciones de los/as docentes en ambos contextos se vería principalmente caracterizado por la dimensión biomédica mientras que la multidimensionalidad, que incorpora nociones políticas, socioculturales y otras, si bien con menor peso, adquirir

  17. Incapacidad laboral por diabetes mellitus: características epidemiológicas y complicaciones macro y microangiopáticas más frecuentes

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    Raúl Jesús Regal Ramos

    2014-03-01

    Full Text Available La diabetes mellitus (DM es la enfermedad metabólica más frecuente y conlleva la disminución en la calidad de vida de los sujetos que la padecen, así como la pérdida de años de vida productiva a consecuencia de las complicaciones crónicas o de la mortalidad. Objetivo: Conocer las características epidemiológicas de los pacientes con invalidez permanente (IP debida a DM y conocer cuáles son las complicaciones más frecuentes que motivaron la IP y su relación con las distintas ocupaciones. Método: Se realizó un estudio descriptivo en el que se recogieron pacientes valorados en la Unidad Médica de la Dirección Provincial del INSS de Madrid entre los años 2005 a 2011 con el diagnóstico de diabetes. Se excluyeron aquellos expedientes que no fueron calificados como IP, aquellos que presentaban otras patologías no relacionadas con la diabetes subsidiarias de probable incapacidad (como procesos oncológicos, demencia, esclerosis múltiple,.. y los casos de diabetes secundarias. Se estudian las variables edad, sexo, estado civil, profesión, régimen de afiliación a la Seguridad Social, y las recogidas en el apartado diagnóstico del informe médico de síntesis (tipo de diabetes, complicaciones derivadas de la DM y factores de riesgo cardiovascular. Resultado: El total de pacientes estudiados fue de 896. Respecto a la población general ocupada de nuestro entorno observamos un 31% más de varones (p< 0,0005; Razón de prevalencia =1,56 y un 28% más de ocupaciones del grupo VII de la CNO-11 (industria y construcción (p < 0,005; Razón de prevalencia =2,3. El 48% de las profesiones científicas y el 36 % de las administrativas estaban diagnosticados de oftalmopatía. El 39% de trabajadores de industria y construcción estaban diagnosticados de algún grado de coronariopatía. Conclusión: Nuestros resultados permiten objetivar que la oftalmopatía es la complicación que más se asocia a invalidez permanente en profesiones de alta

  18. Características epidemiológicas, clínico-patológicas e morfotintoriais de quatorze casos de nocardiose em cães

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    Maria T.S. Frade

    Full Text Available RESUMO: Este artigo descreve os aspectos epidemiológicos, clínicos, patológicos e características morfotintoriais em quatorze casos de nocardiose em cães. Para isso foi realizado um estudo retrospectivo durante o período de janeiro de 2005 a dezembro de 2015 e selecionados os casos sugestivos de nocardiose. A identificação e caracterização do agente foi realizada através de técnicas histoquímicas especiais de Metenamina nitrato de prata de Grocott (GMS, Ziehl-Neelsen modificado, coloração de Gram do tipo Brown-Brenn modificado e Giemsa. Foram afetados predominantemente filhotes e em doze casos havia associação com o vírus da cinomose canina (VCC. Os sinais clínicos variaram de alterações respiratórias, neurológicas e cutâneas, relacionadas principalmente à infecção concomitante pelo VCC. Macroscopicamente haviam áreas multifocais a coalescentes, branco-amareladas, firmes, elevadas na superfície e que se aprofundavam ao corte, por vezes com material purulento, entremeadas por áreas avermelhadas irregulares afetando principalmente pulmões, linfonodos, fígado, rins e encéfalo. As lesões cutâneas foram observadas predominantemente nas regiões cervical e inguinal e variaram de supurativas a piogranulomatosas. No exame histopatológico a lesão era caracterizada principalmente por inflamação piogranulomatosa, porém em algumas áreas havia predomínio de inflamação necrossupurativa, e frequentemente eram observados macrófagos epitelioides, formando aglomerados de forma radiada, muitas vezes lembrando pseudorosetas. Nas técnicas histoquímicas foram observadas estruturas filamentosas, ramificadas, não septadas, medindo aproximadamente 1µm de espessura, impregnadas na coloração de prata, coradas em vermelho no Ziehl-Neelsen modificado, em azul na coloração de Gram do tipo Brown-Brenn modificado e fracamente rósea pálido no Giemsa. A nocardiose deve ser considerada em animais jovens que apresentam sinais

  19. Síndrome da mama fantasma: características clínicas e epidemiológicas Phantom breast syndrome: clinical and epidemiological characteristics

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    Benedito Borges da Silva

    2007-09-01

    Full Text Available OBJETIVO: avaliar as características clínicas e epidemiológicas de pacientes com o diagnóstico de síndrome da mama fantasma (SdMF ou com fenômenos fantasmas isoladamente. MÉTODOS: realizou-se um estudo observacional descritivo do tipo transversal, envolvendo 98 pacientes tratadas por câncer de mama no Hospital São Marcos, em Teresina (PI, empregando um questionário padronizado. RESULTADOS: observou-se SdMF em 11,2% das pacientes e sensação fantasma isolada em 30% das pacientes. A média de idade foi 54 anos. Cinqüenta e nove pacientes eram casadas (60% e 79,6% eram analfabetas ou não haviam concluído o ensino médio. Alterações emocionais estavam presentes em 67,4%, embora em 66,7% a libido não tenha mudado após o procedimento cirúrgico. Como fator de melhora da dor fantasma, o repouso foi citado por 90,9% das pacientes, enquanto esforços físicos foram mencionados como fator de exacerbação dos sintomas em 63,6% dos casos. A média da nota atribuída à dor em escala de 0 a 10 foi 3, variando de 1 a 7. Apenas 3% das pacientes sabiam da existência desta síndrome antes da realização das entrevistas. CONCLUSÕES: fenômenos fantasmas são freqüentes em pacientes mastectomizadas, havendo necessidade de mais estudos para que se conheçam melhor suas características e o impacto sobre a qualidade de vida dessas mulheres.PURPOSE: to evaluate the clinical and epidemiological characteristics of patients with the diagnosis of phantom breast syndrome or with phantom phenomena lonely. METHODS: it was conducted an observational, descriptive and sectional study enrolling 98 patients treated for breast cancer at Hospital São Marcos, Teresina (PI, Brazil. A standardized questionnaire was applied. RESULTS: the phantom breast syndrome was observed in 11.2% of the patients and phantom sensation alone was observed in 30% of the patients. The mean age of the patients was 54 years. Fifty-nine patients were married (60% and 79.5% were

  20. Conocimientos sobre shigellosis y su manejo epidemiológico en personal médico Knowledges on shigellosis and its epidemiological management in medical staff

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    Alvin Mena Cantero

    2010-03-01

    Full Text Available Introducción: la Shigella como agente causal de episodios diarreicos con sangre ha sido el germen aislado con mayor frecuencia en los laboratorios clínicos, no obstante, el número de casos reportados por el Sistema de Enfermedades de Declaración Obligatoria es inferior, lo que demuestra un subregistro en su notificación. Objetivos: elevar el nivel de conocimientos de médicos y alumnos internos sobre la shigellosis. Métodos: se realizó un estudio cuasi experimental antes-después, de una intervención educativa sobre la shigellosis y su manejo epidemiológico. La investigación se hizo en los policlínicos comunitarios docentes "Marcio Manduley" y "Nguyen Van Troi" en el período de enero a junio de 2008. La muestra quedó conformada por 64 médicos, de ellos 21 eran alumnos internos. Todos expresaron su consentimiento para participar en la investigación. Se aplicó la prueba no paramétrica ji cuadrada con un nivel de significación de p Introduction: Shigella as causal agent of diarrheic episodes with presence of blood has been the more frequent isolated agent in clinical laboratories; however, the number of cases reported by System of Diseases of Mandatory Statement is lower demonstrating a sub-registry of its notification. Objectives: to confirm the knowledge level of medical staff on the Shigellosis. Methods: a quasi-experimental study was conducted before and after a educational intervention on the Shigellosis and its epidemiological management. Research was made in the "Marcio Manduley" and "Nguyen Van Troi" Teaching and Community polyclinics from January to June, 2008. Sample included 43 physicians and 21 internal students in which the intervention was applied. Information was obtained by application of anonymous questionnaire. Results: before intervention it was possible to verify that taxonomic knowledges were satisfactory in only 9 polled persons for a 14,06%, after it, the figure of persons with a good level of knowledges