WorldWideScience

Sample records for epi info software

  1. EpiData: ¿el heredero natural de EpiInfo 6? EpiData: the natural heir to EpiInfo 6?

    Directory of Open Access Journals (Sweden)

    Pedro Arias Bohigas

    2007-06-01

    Full Text Available EpiData es un programa informático desarrollado por la Asociación EpiData (www.epidata.dk que, siguiendo la filosofía de EpiInfo 6, pretende ofrecer todas las ventajas de ese programa: sencillez, aplicabilidad, pocos requerimientos del sistema operativo y de los sistemas de comunicación, ampliándolas con un enfoque claro hacia lo documentación y la calidad de los datos, y las ventajas que para muchos usuarios tiene el entorno Windows®. El objetivo de esta Nota es presentar a los potenciales usuarios las ventajas y limitaciones de EpiData, que puede ser en breve tiempo el equivalente a lo que EpiInfo 6 fue hace unos pocos años.EpiData is an epidemiological software developed by the EpiData Association (www.epidata.dk. Following the EpiInfo 6 philosophy, Epidata, offers all the advantages of EpiInfo 6: simplicity, applicability, few operation and communication system requirements, widening them with a clear focus on data quality and documentation plus the advantages that, for many users, has the Windows® operating system. The aim of this Note is to introduce to potential users the strengths and limitations of EpiData, a software that can become in a short time the equivalent to what EpiInfo 6 was a few years ago.

  2. Epi Info™ 7

    Centers for Disease Control (CDC) Podcasts

    2012-06-12

    In this podcast, Brad Myers, Director of the Division of Communication Services, talks with Asad Islam, who leads the Epi Info™ team at CDC, about Epi Info's new tools.  Created: 6/12/2012 by Office of Surveillance, Epidemiology, and Laboratory Services (OSELS).   Date Released: 1/17/2013.

  3. Software EpiData - Applications for Needs of Biotechnological Processes

    Directory of Open Access Journals (Sweden)

    Ljakova K.

    2007-12-01

    Full Text Available EpiData (free software for entering and documenting data is presented. Some aspect of this software is shown for needs of database system (DB and information systems (IS that can be used in bioprocess system.

  4. INFOS: spectrum fitting software for NMR analysis

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Albert A., E-mail: alsi@nmr.phys.chem.ethz.ch [ETH Zürich, Physical Chemistry (Switzerland)

    2017-02-15

    Software for fitting of NMR spectra in MATLAB is presented. Spectra are fitted in the frequency domain, using Fourier transformed lineshapes, which are derived using the experimental acquisition and processing parameters. This yields more accurate fits compared to common fitting methods that use Lorentzian or Gaussian functions. Furthermore, a very time-efficient algorithm for calculating and fitting spectra has been developed. The software also performs initial peak picking, followed by subsequent fitting and refinement of the peak list, by iteratively adding and removing peaks to improve the overall fit. Estimation of error on fitting parameters is performed using a Monte-Carlo approach. Many fitting options allow the software to be flexible enough for a wide array of applications, while still being straightforward to set up with minimal user input.

  5. Emerging Pathogens Initiative (EPI)

    Data.gov (United States)

    Department of Veterans Affairs — The Emerging Pathogens Initiative (EPI) database contains emerging pathogens information from the local Veterans Affairs Medical Centers (VAMCs). The EPI software...

  6. EpiTools, A software suite for presurgical brain mapping in epilepsy: Intracerebral EEG.

    Science.gov (United States)

    Medina Villalon, S; Paz, R; Roehri, N; Lagarde, S; Pizzo, F; Colombet, B; Bartolomei, F; Carron, R; Bénar, C-G

    2018-03-29

    In pharmacoresistant epilepsy, exploration with depth electrodes can be needed to precisely define the epileptogenic zone. Accurate location of these electrodes is thus essential for the interpretation of Stereotaxic EEG (SEEG) signals. As SEEG analysis increasingly relies on signal processing, it is crucial to make a link between these results and patient's anatomy. Our aims were thus to develop a suite of software tools, called "EpiTools", able to i) precisely and automatically localize the position of each SEEG contact and ii) display the results of signal analysis in each patient's anatomy. The first tool, GARDEL (GUI for Automatic Registration and Depth Electrode Localization), is able to automatically localize SEEG contacts and to label each contact according to a pre-specified nomenclature (for instance that of FreeSurfer or MarsAtlas). The second tool, 3Dviewer, enables to visualize in the 3D anatomy of the patient the origin of signal processing results such as rate of biomarkers, connectivity graphs or Epileptogenicity Index. GARDEL was validated in 30 patients by clinicians and proved to be highly reliable to determine within the patient's individual anatomy the actual location of contacts. GARDEL is a fully automatic electrode localization tool needing limited user interaction (only for electrode naming or contact correction). The 3Dviewer is able to read signal processing results and to display them in link with patient's anatomy. EpiTools can help speeding up the interpretation of SEEG data and improving its precision. Copyright © 2018 Elsevier B.V. All rights reserved.

  7. Informatics in Radiology (infoRAD): personal computer security: part 2. Software Configuration and file protection.

    Science.gov (United States)

    Caruso, Ronald D

    2004-01-01

    Proper configuration of software security settings and proper file management are necessary and important elements of safe computer use. Unfortunately, the configuration of software security options is often not user friendly. Safe file management requires the use of several utilities, most of which are already installed on the computer or available as freeware. Among these file operations are setting passwords, defragmentation, deletion, wiping, removal of personal information, and encryption. For example, Digital Imaging and Communications in Medicine medical images need to be anonymized, or "scrubbed," to remove patient identifying information in the header section prior to their use in a public educational or research environment. The choices made with respect to computer security may affect the convenience of the computing process. Ultimately, the degree of inconvenience accepted will depend on the sensitivity of the files and communications to be protected and the tolerance of the user. Copyright RSNA, 2004

  8. Supporting Info

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supporting Info. This dataset is associated with the following publication: Washington , J., and T. Jenkins. Abiotic Hydrolysis of Fluorotelomer-Based Polymers as a...

  9. Invoicing, Payments Info

    Science.gov (United States)

    Goals Recycling Green Purchasing Pollution Prevention Reusing Water Resources Environmental Management Vendors Invoicing, Payments Info Bidding Opportunities Code of Conduct regarding holiday gifts Business

  10. Informatics in radiology (infoRAD): free DICOM image viewing and processing software for the Macintosh computer: what's available and what it can do for you.

    Science.gov (United States)

    Escott, Edward J; Rubinstein, David

    2004-01-01

    It is often necessary for radiologists to use digital images in presentations and conferences. Most imaging modalities produce images in the Digital Imaging and Communications in Medicine (DICOM) format. The image files tend to be large and thus cannot be directly imported into most presentation software, such as Microsoft PowerPoint; the large files also consume storage space. There are many free programs that allow viewing and processing of these files on a personal computer, including conversion to more common file formats such as the Joint Photographic Experts Group (JPEG) format. Free DICOM image viewing and processing software for computers running on the Microsoft Windows operating system has already been evaluated. However, many people use the Macintosh (Apple Computer) platform, and a number of programs are available for these users. The World Wide Web was searched for free DICOM image viewing or processing software that was designed for the Macintosh platform or is written in Java and is therefore platform independent. The features of these programs and their usability were evaluated. There are many free programs for the Macintosh platform that enable viewing and processing of DICOM images. (c) RSNA, 2004.

  11. Central Asian Republic Info

    Data.gov (United States)

    US Agency for International Development — CAR Info is designed and managed by the Central Asian Republic Mission to fill in the knowledge and reporting gaps in existing agency systems for that Mission. It...

  12. Info@performance

    DEFF Research Database (Denmark)

    Jespersen, Kristina Risom

    2003-01-01

    The design of interactive methods for collecting can benefit from the Web-technology. Info@performance.NPD illustrate the combination of experimental design, role-playing and a scenario build on Web-based technology. Having created a simulation of a new product development process, Info@performan......@performance.NPD is an example of how data collection can be done through the Internet. The opportunities of combining several methodological designs with aid of Web-technology are unlimited....

  13. 2008 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2008 Environmental Performance Index (EPI) centers on two broad environmental protection objectives: (1) reducing environmental stresses on human health, and (2)...

  14. Epi-Soho Pilotproject; Das Epi-Soho Pilotprojekt

    Energy Technology Data Exchange (ETDEWEB)

    Hinz, E.; Enseling, A. [Inst. Wohnen und Umwelt GmbH, Darmstadt (Germany)

    2008-07-01

    EPI-SoHo is a project within the framework of the European 'Intelligent Energy - Europe' Programme (IEE). The EPI-SoHo mission is to improve efficient and rational use of energy across social housing stocks, contributing to better standards of living and global environ-mental benefits. The EPI-SoHo objectives are to develop the structure for generic implementation techniques for cost effective, large scale energy performance assessments, for the integration of energy efficiency within social housing portfolio management and collaborative structures between local authorities, social housing associations and private actors on sustainable issues. (orig.)

  15. 2014 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2014 Environmental Performance Index (EPI) ranks 178 countries on 20 performance indicators in the following 9 policy categories: health impacts, air quality,...

  16. 2016 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2016 Environmental Performance Index (EPI) ranks 180 countries on 20 performance indicators in the following 9 policy categories: health impacts, air quality,...

  17. 2010 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The 2010 Environmental Performance Index (EPI) ranks 163 countries on environmental performance based on twenty-five indicators grouped within ten core policy...

  18. Software

    Energy Technology Data Exchange (ETDEWEB)

    Macedo, R.; Budd, G.; Ross, E.; Wells, P.

    2010-07-15

    The software section of this journal presented new software programs that have been developed to help in the exploration and development of hydrocarbon resources. Software provider IHS Inc. has made additions to its geological and engineering analysis software tool, IHS PETRA, a product used by geoscientists and engineers to visualize, analyze and manage well production, well log, drilling, reservoir, seismic and other related information. IHS PETRA also includes a directional well module and a decline curve analysis module to improve analysis capabilities in unconventional reservoirs. Petris Technology Inc. has developed a software to help manage the large volumes of data. PetrisWinds Enterprise (PWE) helps users find and manage wellbore data, including conventional wireline and MWD core data; analysis core photos and images; waveforms and NMR; and external files documentation. Ottawa-based Ambercore Software Inc. has been collaborating with Nexen on the Petroleum iQ software for steam assisted gravity drainage (SAGD) producers. Petroleum iQ integrates geology and geophysics data with engineering data in 3D and 4D. Calgary-based Envirosoft Corporation has developed a software that reduces the costly and time-consuming effort required to comply with Directive 39 of the Alberta Energy Resources Conservation Board. The product includes an emissions modelling software. Houston-based Seismic Micro-Technology (SMT) has developed the Kingdom software that features the latest in seismic interpretation. Holland-based Joa Oil and Gas and Calgary-based Computer Modelling Group have both supplied the petroleum industry with advanced reservoir simulation software that enables reservoir interpretation. The 2010 software survey included a guide to new software applications designed to facilitate petroleum exploration, drilling and production activities. Oil and gas producers can use the products for a range of functions, including reservoir characterization and accounting. In

  19. lessons and challenges from software quality assessment

    African Journals Online (AJOL)

    DJFLEX

    www.globaljournalseries.com, Email: info@globaljournalseries.com ... ASSESSMENT: THE CASE OF SPACE SYSTEMS SOFTWARE. ... KEYWORDS: Software, Software Quality ,Quality Standard, Characteristics, ... and communication, etc.

  20. Pilot 2006 Environmental Performance Index (EPI)

    Data.gov (United States)

    National Aeronautics and Space Administration — The Pilot 2006 Environmental Performance Index (EPI) centers on two broad environmental protection objectives: (1) reducing environmental stresses on human health,...

  1. EPI moved in beam S3

    CERN Multimedia

    1977-01-01

    The housing of the External Particle Identifier (EPI) is being moved to S3 beam. Test measurements with EPI were performed in the S3 beam between 20 and 110 GeV/c, before installing it behind BEBC. 110 GeV/c before

  2. EpiModel: An R Package for Mathematical Modeling of Infectious Disease over Networks.

    Science.gov (United States)

    Jenness, Samuel M; Goodreau, Steven M; Morris, Martina

    2018-04-01

    Package EpiModel provides tools for building, simulating, and analyzing mathematical models for the population dynamics of infectious disease transmission in R. Several classes of models are included, but the unique contribution of this software package is a general stochastic framework for modeling the spread of epidemics on networks. EpiModel integrates recent advances in statistical methods for network analysis (temporal exponential random graph models) that allow the epidemic modeling to be grounded in empirical data on contacts that can spread infection. This article provides an overview of both the modeling tools built into EpiModel , designed to facilitate learning for students new to modeling, and the application programming interface for extending package EpiModel , designed to facilitate the exploration of novel research questions for advanced modelers.

  3. EpiCollect+: linking smartphones to web applications for complex data collection projects.

    Science.gov (United States)

    Aanensen, David M; Huntley, Derek M; Menegazzo, Mirko; Powell, Chris I; Spratt, Brian G

    2014-01-01

    Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry), whereas many applications require a more complex structure, allowing users to link a series of forms in a linear or branching hierarchy, along with the addition of any number of media types accessible from smartphones and/or tablet devices (e.g., GPS, photos, videos, sound clips and barcode scanning). A much enhanced version of EpiCollect has been developed (EpiCollect+). The individual data collection forms in EpiCollect+ provide more design complexity than the single form used in EpiCollect, and the software allows the generation of complex data collection projects through the ability to link many forms together in a linear (or branching) hierarchy. Furthermore, EpiCollect+ allows the collection of multiple media types as well as standard text fields, increased data validation and form logic. The entire process of setting up a complex mobile phone data collection project to the specification of a user (project and form definitions) can be undertaken at the EpiCollect+ website using a simple 'drag and drop' procedure, with visualisation of the data gathered using Google Maps and charts at the project website. EpiCollect+ is suitable for situations where multiple users transmit complex data by mobile phone (or other Android devices) to a single project web database and is already being used for a range of field projects, particularly public health projects in sub-Saharan Africa. However, many uses can be envisaged from education, ecology and epidemiology to citizen science.

  4. Module of External Particle Identifier (EPI)

    CERN Multimedia

    1977-01-01

    The EPI consisted of 4096 proportional counters 6x6 cm2, distributed in 128 layers of 32 each. It was used downstream of BEBC for the identification of fast forward secondaries by ionization measurements in the region of relativistic rise, see M. Aderholz et al., Nucl. Instr. & Methods 123 (1975) 237. The photo shows one double layer module of the EPI during the construction, see M. Aderholz et al., Nucl. Instr. & Methods 118 (1974) 419. On the left, Ivan Lehraus.

  5. InfoMall: An Innovative Strategy for High-Performance Computing and Communications Applications Development.

    Science.gov (United States)

    Mills, Kim; Fox, Geoffrey

    1994-01-01

    Describes the InfoMall, a program led by the Northeast Parallel Architectures Center (NPAC) at Syracuse University (New York). The InfoMall features a partnership of approximately 24 organizations offering linked programs in High Performance Computing and Communications (HPCC) technology integration, software development, marketing, education and…

  6. Going national with EPI in Nigeria.

    Science.gov (United States)

    Reid, R S; Smith, E A

    1984-01-01

    The basic purposes set out for the Owo Local Government Area (LGA) Expanded Program on Immunization (EPI) model project in Ondo State, Nigeria, were: to demonstrate in 1 LGA that 80% EPI coverage can be achieved within the resources that the government normally provides to EPI; to dispel the unquestioning acquiescence that 10-15% coverage is all that can be done; to demonstrate that the health establishment at large can be convinced of these approaches and processes and can be expected to adopt them for a much wider dissemination; to show that a substantial number of health officers and workers are willing to work toward a higher EPI achievement; and to prove that resources from various origins can be integrated given the proper operational environment and a tight organization. The problems associated with EPI are basically similar in all Nigeria, leading to the decision to undertake a model project in a selected area. The EPI project was designed to break ground in Owo for further elements of primary health care. The project's objective was to capitalize upon the success and experience in EPI to introduce other health-related and self-help activities to communities. The project was organized with an overall project director exercising broad control and supervision over a management group at the project level. The management group is made up of a project manager, an assistant project manager, and heads of functional areas such as field operation, vaccine management system, transport system, mobile operation, health education, and administration and finance. The simple organization was designed to grow gradually to meet heavier volumes of work, altering and modifying approaches as required. The 2 key technical elements in the Owo approach were greatly increased use of cold packs and a decreased reliance on refrigerators; and increased use of simple static centers to reach remote catchment areas, instead of relying heavily on the mobile units. In both elements, the

  7. epi-Cubebanes from Solidago canadensis.

    Science.gov (United States)

    Kasali, Adeleke A; Ekundayo, Olusegun; Paul, Claudia; König, Wilfried A

    2002-04-01

    GC-MS of the essential oil prepared by hydrodistillation of the green parts of a specimen of Solidago canadensis collected near Katowice, Poland, revealed two new sesquiterpene hydrocarbons. Their EI mass spectra resembled the mass spectrum of beta-ylangene (1) but the retention indices of the new compounds differed markedly from this known compound. After isolation of the new compounds by preparative GC their investigation by one- and two-dimensional NMR techniques resulted in the identification of 6-epi-alpha-cubebene (2) (minor constituent, 1.5%) and 6-epi-beta-cubebene (3) (major constituent, 20.5%).

  8. 337Info - Unfair Import Investigations Information System

    Data.gov (United States)

    US International Trade Commission — The 337Info database contains data relating to Section 337 investigations instituted, or otherwise initiated, by the U.S. International Trade Commission on or after...

  9. Open Source Software Development

    Science.gov (United States)

    2011-01-01

    appropriate to refer to FOSS or FLOSS (L for Libre , where the alternative term “ libre software ” has popularity in some parts of the world) in order...Applying Social Network Analysis to Community-Drive Libre Software Projects, Intern. J. Info. Tech. and Web Engineering, 2006, 1(3), 27-28. 17...Open Source Software Development* Walt Scacchi Institute for Software Researcher University of California, Irvine Irvine, CA 92697-3455 USA Abstract

  10. EpiReumaPt: how to perform a national population based study – a practical guide

    Directory of Open Access Journals (Sweden)

    Nélia Gouveia

    2015-04-01

    Full Text Available Background: The aim of this article was to describe and discuss several strategies and standard operating procedures undertaken in the EpiReumaPt study – which was the first Portuguese, national, cross-sectional population-based study of Rheumatic and Musculoskeletal Diseases (RMD. Methods: The technical procedures, legal issues, management and practical questions were studied, analyzed and discussed with relevant stakeholders. During the 1st phase of EpiReumaPt the coordination team and Centro de Estudos de Sondagens e Opinião (CESOP worked to recruit and interview 10,661 subjects. The 2nd phase involved the participation of a multidisciplinary team, several local authorities, a specialized vehicle (“mobile unit” and a specific software program for the clinical appointments. The development of specific recruitment strategies improved the participation rate. Blood samples were collected and sent to Biobanco-IMM and to a central lab for immediate measurements. In the 3rd phase the RMD diagnosis were validated by a team of three experienced rheumatologists - clinical data, imaging and lab test results were revised according to previously published classification criteria. Conclusion: EpiReumaPt was a nationwide project successfully conducted, which followed critical logistic/coordination and research strategies. EpiReumaPt methodology and coordination could be used as an example for other epidemiologic endeavors and public health policies.

  11. Encoding Collocations in DiCoInfo

    DEFF Research Database (Denmark)

    Leroyer, Patrick; L'Homme, Marie-Claude; Robichaud, Benoît

    2012-01-01

    This contribution presents an online lexical database and shows how some of its data categories were converted to make them more accessible to users. The database is called DiCoInfo and contains English, French, and Spanish terms related to the fields of computing and the Internet. Entries...

  12. Infoühiskond / Raivo Suni

    Index Scriptorium Estoniae

    Suni, Raivo, 1976-

    1999-01-01

    Infoühiskond on paradigmana sattunud sotsiaalteadlaste tähelepanu alla seoses informatsiooni plahvatusliku väärtustumisega viimastele aastatel. Ka kultuuriimperialismist, kulturoloogilisest lähenemisest. Meediatehnoloogia areng on aidanud levida väärtustel, mis varem olid kättesaadavad vaid eliidile (Walter Benjamin "The Work of Art in the Age of Mechanical Reproduction")

  13. Info Source | IDRC - International Development Research Centre

    International Development Research Centre (IDRC) Digital Library (Canada)

    Info Source: Sources of Federal Government and Employee Information provides ... Bringing together the right partners around opportunities for impact, IDRC builds ... Internal services constitute groups of related activities and resources that are ... including planning, budgeting, accounting, reporting, control and oversight, ...

  14. epi-Aszonalenins A, B, and C from Aspergillus novofumigatus

    DEFF Research Database (Denmark)

    Rank, Christian; Phipps, Richard Kerry; Harris, Pernille

    2006-01-01

    Three new benzodiazepines have been isolated from an unusual chemotype of Aspergillus novofumigatus: epi-aszonalenins A, B, and C. The structures were elucidated by use of one- and two-dimensional NMR spectroscopic techniques and HR ESI MS. The relative configuration was established on the basis...... of a single crystal X-ray diffraction study of epi-aszonalenin A and the absolute configuration was determined by optical rotation comparison with the literature data. The absolute configurations of epi-aszonalenins B and C were determined by circular dichroism comparison to epi-aszonalenin A....

  15. Designing environmental performance indicators (EPIs) for eco-efficiency

    International Nuclear Information System (INIS)

    Campbell, B.

    1997-01-01

    Environmental performance indicators (EPI) were discussed and a method by which companies can design indicators to help measure their progress toward greater eco-efficiency was presented. EPIs are quantitative measures of environmental performance. EPIs can measure one attribute, such as effluent released to water, or they can be a complex index. EPIs track impacts on the environment and provide information for decision making. The need for more eco-efficient companies, i.e. companies that produce useful goods and services while reducing their consumption of resources and while making efforts to reduce pollution, was emphasized

  16. Physics of epi-thermal boron neutron capture therapy (epi-thermal BNCT).

    Science.gov (United States)

    Seki, Ryoichi; Wakisaka, Yushi; Morimoto, Nami; Takashina, Masaaki; Koizumi, Masahiko; Toki, Hiroshi; Fukuda, Mitsuhiro

    2017-12-01

    The physics of epi-thermal neutrons in the human body is discussed in the effort to clarify the nature of the unique radiologic properties of boron neutron capture therapy (BNCT). This discussion leads to the computational method of Monte Carlo simulation in BNCT. The method is discussed through two examples based on model phantoms. The physics is kept at an introductory level in the discussion in this tutorial review.

  17. Software Products - Naval Oceanography Portal

    Science.gov (United States)

    are here: Home › USNO › Astronomical Applications › Software Products USNO Logo USNO Navigation Data Services Astronomical Information Center Almanacs and Other Publications Software Products For DoD Users Info Software Products MICA - Multiyear Interactive Computer Almanac MICA CDROM (thumb) MICA is an

  18. EpiCollect+: linking smartphones to web applications for complex data collection projects [v1; ref status: indexed, http://f1000r.es/3vk

    Directory of Open Access Journals (Sweden)

    David M. Aanensen

    2014-08-01

    Full Text Available Previously, we have described the development of the generic mobile phone data gathering tool, EpiCollect, and an associated web application, providing two-way communication between multiple data gatherers and a project database. This software only allows data collection on the phone using a single questionnaire form that is tailored to the needs of the user (including a single GPS point and photo per entry, whereas many applications require a more complex structure, allowing users to link a series of forms in a linear or branching hierarchy, along with the addition of any number of media types accessible from smartphones and/or tablet devices (e.g., GPS, photos, videos, sound clips and barcode scanning. A much enhanced version of EpiCollect has been developed (EpiCollect+. The individual data collection forms in EpiCollect+ provide more design complexity than the single form used in EpiCollect, and the software allows the generation of complex data collection projects through the ability to link many forms together in a linear (or branching hierarchy. Furthermore, EpiCollect+ allows the collection of multiple media types as well as standard text fields, increased data validation and form logic. The entire process of setting up a complex mobile phone data collection project to the specification of a user (project and form definitions can be undertaken at the EpiCollect+ website using a simple ‘drag and drop’ procedure, with visualisation of the data gathered using Google Maps and charts at the project website. EpiCollect+ is suitable for situations where multiple users transmit complex data by mobile phone (or other Android devices to a single project web database and is already being used for a range of field projects, particularly public health projects in sub-Saharan Africa. However, many uses can be envisaged from education, ecology and epidemiology to citizen science.

  19. Psychometric properties of the Plutchik's EPI test (Emotions Profile Index

    Directory of Open Access Journals (Sweden)

    Ana Trebovc

    2005-04-01

    Full Text Available Authors report a study on psychometric properties of Plutchik's test, called Emotions Profile Index (EPI. A new Slovene translation and adaptation of English version of the test, consisting of combinations (pairs of 12 words reflecting eight different emotional conditions, was prepared and compared to the old one. Both versions as well as the Big Five Questionnaire (BFQ were administered on the sample of 239 participants. Different statistical analyses were performed examining psychometric features of both versions of EPI. Discriminative power was tested by cluster analysis and analysis of frequency distributions, reliability was studied via internal consistency index and correlation between the two versions, and validity was examined by correlating PIE dimensions with BFQ dimensions and subdimensions, by comparing profiles of groups on both versions of EPI and BFQ and by fitting the theoretical model proposed by Plutchik to the data. Discriminative power of EPI seems to be affected by avoiding (not choosing the socially desirable expressions in the test, parallel reliability seems to be susceptible to the use of different words (expressions in the new version of EPI having the same meaning as words in the old version. Dimensions expected to reflect similar constructs in BFQ and EPI do not correlate satisfactory. Data gathered with EPI cannot be fully explained with the model proposed by Plutchik's theory.

  20. Cognitive infocommunications (CogInfoCom)

    CERN Document Server

    Baranyi, Péter; Sallai, Gyula

    2015-01-01

    This book describes the theoretical foundations of cognitive infocommunications (CogInfoCom), and provides a survey on state-of-the-art solutions and applications within the field. The book covers aspects of cognitive infocommunications in the research fields of affective computing, BCI, future internet, HCI, HRI, sensory substitution, and virtual/augmented interactions. The book focuses on describing the merging between humans and information and communications technology (ICT) at the level of cognitive capabilities with an approach towards developing future cognitive ICT.   · Provides a comprehensive overview of cognitive infocommunications   · Covers theoretical and practical aspects of cognitive infocommunications   · Discusses applications employing various aspects of infocommunication.

  1. Plan de negocio Security Info Consultores

    OpenAIRE

    Cardona Cubillos, Diego Alejandro

    2013-01-01

    La empresa a crear tiene como razón social Security Info Consultores, con domicilio principal en la ciudad de Bogotá, y su servicio principal consiste en implementar un modelo de seguridad informática acorde a cada empresa, en dar charlas y conferencia sobre normatividad, correcta custodia de la información, concientización sobre la importancia del manejo de la información, capacitar al personal para que tengan un conocimiento detallado y claro sobre le modelo implantado, desarrollar audito...

  2. BOREAS Elevation Contours over the NSA and SSA in ARC/INFO Generate Format

    Science.gov (United States)

    Knapp, David; Nickeson, Jaime; Hall, Forrest G. (Editor)

    2000-01-01

    This data set was prepared by BORIS Staff by reformatting the original data into the ARC/INFO Generate format. The original data were received in SIF at a scale of 1:50,000. BORIS staff could not find a format document or commercial software for reading SIF; the BOREAS HYD-08 team pro-vided some C source code that could read some of the SIF files. The data cover the BOREAS NSA and SSA. The original data were compiled from information available in the 1970s and 1980s. The data are available in ARC/INFO Generate format files.

  3. Creating Simple Admin Tools Using Info*Engine and Java

    Science.gov (United States)

    Jones, Corey; Kapatos, Dennis; Skradski, Cory; Felkins, J. D.

    2012-01-01

    PTC has provided a simple way to dynamically interact with Windchill using Info*Engine. This presentation will describe how to create a simple Info*Engine Tasks capable of saving Windchill 10.0 administration of tedious work.

  4. Kas info on sõnum? / David Vseviov

    Index Scriptorium Estoniae

    Vseviov, David, 1949-

    2009-01-01

    Tõeline infoühiskond oli vanaaja ühiskond. Infoühiskonnaks saab pidada vaid sellist ühiskonda, kus valdavale osale indiviididest teada olev informatsioon suudab kindlustada inimese iseseisva eksistentsi

  5. EpiNet : Revue électronique de l'EPI, Année 2006, n° 81-90

    OpenAIRE

    Viaud, Jean-Bernard

    2006-01-01

    Fayon, D. (2006). Les nouveaux outils en entreprise. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2006, (81).a0601aArchambault, J.-P. (2006). Un dispositif départemental pour les TIC : le CRI de la Haute-Savoie. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2006, (81).a0601bCaraballo, S., Cicala, R. (2006). Vers une Didactique de l'Informatique. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. ...

  6. A BIM-Info delivery protocol

    Directory of Open Access Journals (Sweden)

    Martin Hooper

    2015-10-01

    Full Text Available Today, with many of the technological issues of integrated information management resolved (perhaps excluding the matter of interoperability, defining the content and status of BIM information deliveries remains both a practical and a theoretical problem. New BIM tools and new design processes and procedures have led to a certain confusion of what information is needed for particular BIM uses. This paper seeks to explore and enable a method of defining the content of model information deliverables through a review of 2 key primary specific BIM uses: 3d Design Coordination and Early Energy Appraisal through an analysis of practical application. The scope of this study is limited to a review of information flow within residential projects in a Swedish context and looks at two projects with a view to identify and establish a common definition of the key BIM objects and properties necessary for particular tasks. The key deliverable from this study is the BIM-Info Delivery Protocol (IDP which attempts to align consultant BIM-information delivery expectations and represents a tangible solution to assist consultants to manage BIM information. Concluding reflections consider the positioning of the IDP relative to the on-going development of IDMs / MVDs and highlight the key constituent parameters of an Information Delivery Specification (IDS.

  7. The ALICE DAQ infoLogger

    Science.gov (United States)

    Chapeland, S.; Carena, F.; Carena, W.; Chibante Barroso, V.; Costa, F.; Dénes, E.; Divià, R.; Fuchs, U.; Grigore, A.; Ionita, C.; Delort, C.; Simonetti, G.; Soós, C.; Telesca, A.; Vande Vyvre, P.; Von Haller, B.; Alice Collaboration

    2014-04-01

    ALICE (A Large Ion Collider Experiment) is a heavy-ion experiment studying the physics of strongly interacting matter and the quark-gluon plasma at the CERN LHC (Large Hadron Collider). The ALICE DAQ (Data Acquisition System) is based on a large farm of commodity hardware consisting of more than 600 devices (Linux PCs, storage, network switches). The DAQ reads the data transferred from the detectors through 500 dedicated optical links at an aggregated and sustained rate of up to 10 Gigabytes per second and stores at up to 2.5 Gigabytes per second. The infoLogger is the log system which collects centrally the messages issued by the thousands of processes running on the DAQ machines. It allows to report errors on the fly, and to keep a trace of runtime execution for later investigation. More than 500000 messages are stored every day in a MySQL database, in a structured table keeping track for each message of 16 indexing fields (e.g. time, host, user, ...). The total amount of logs for 2012 exceeds 75GB of data and 150 million rows. We present in this paper the architecture and implementation of this distributed logging system, consisting of a client programming API, local data collector processes, a central server, and interactive human interfaces. We review the operational experience during the 2012 run, in particular the actions taken to ensure shifters receive manageable and relevant content from the main log stream. Finally, we present the performance of this log system, and future evolutions.

  8. Divergent Synthesis of Solanidine and 22-epi-Solanidine.

    Science.gov (United States)

    Hou, Ling-Li; Shi, Yong; Zhang, Zhi-Dan; Wu, Jing-Jing; Yang, Qing-Xiong; Tian, Wei-Sheng

    2017-07-21

    A divergent synthesis of solanidine and 22-epi-solanidine, two 25S natural steroidal alkaloids, from 25R-configured diosgenin acetate, is described. Initially, solanidine was synthesized through a series of transformations including a cascade ring-switching process of furostan-26-acid, an epimerization of C25 controlled by the conformation of six-membered lactone ring, an intramolecular Schmidt reaction, and an imine reduction/intramolecular aminolysis process. To address the epimerization issue during Schmidt reaction, an improved synthesis was developed, which also led to a synthesis of 22-epi-solanidine. In this synthesis, selective transformation of azido lactone to azido diol and amino diol was realized through a reduction relay tactic. The azido diol was transformed to solanidine via an intramolecular Schmidt reaction/N-alkylation/reduction process and to 22-epi-solanidine via an intramolecular double N-alkylation process.

  9. Riigipead mõtestavad infoühiskonda / Imre Siil

    Index Scriptorium Estoniae

    Siil, Imre

    2003-01-01

    Rahvusvahelise Telekommunikatsiooniliidu (International Telecommunications Union, ITU) algatusel ettevalmistatavast maailma infoühiskonna alasest tippkohtumisest (World Summit on Information Society, WSIS)

  10. EpiNet : Revue électronique de l'EPI, Année 2012, n° 141-150

    OpenAIRE

    Archambault, Jean-Pierre

    2012-01-01

    Accès aux articles et documents dans le fichier attaché index.html. EPI, Archambault, J.-P. (2012). Éditorial : Une commission de l'Académie des Sciences sur l'enseignement de l'informatique. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2012, (141). a1201a Archambault, J.-P. (2012). Au bout de dix ans de pratique du B2i, nous constatons un échec. EpiNet : Revue électronique de l'EPI (Enseignement Public & Informatique), jan. 2012, (141). a1201b Karsenti, ...

  11. Ultrafast MR imaging with EPI of organs undergoing nonperiodic motion

    International Nuclear Information System (INIS)

    Stehling, M.K.; Ordidge, R.J.; Howseman, A.M.; Coxon, R.; Chapman, B.; Mansfield, P.

    1988-01-01

    Conventional MR imaging employing repetitive data acquisition is susceptible to motion artifacts. Gating overcomes periodic motion effects. Nonperiodic motion, as encountered in the gastronintestinal tract, cardiac arrhythmias, unsedated children, and fetal imaging, thwarts conventional MR imaging. The EPI derivatives BEST and MBEST create a complex 128 x 128-pixel image in 64 msec and 128 msec, respectively, freezing motion almost completely. Sequentially recorded gastrointestinal-tract images allow quantitative evaluation of gastric and gut motility. Cardiac morphology, movement, and blood flow patterns in valvular heart disease have been depicted during atrial fibrillation. Selected clinical results with accompanying technical details illustrate the scope of EPI as a distinctive imaging modality

  12. Synthesis of ()-albrassitriol and ()-6-epi-albrassitriol from (+)-larixol

    NARCIS (Netherlands)

    Vlad, P.F.; Ciocarlan, A.; Coltsa, M.; Edu, C.; Biriiac, A.; Barba, A.; Deleanu, C.; Nicolescu, A.; Ambrosio, D' M.; Groot, de Æ.

    2013-01-01

    A novel synthesis of natural drimanic compounds, ()-albrassitriol (2) and ()-6-epi-albrassitriol (3), has been carried out starting from an easily available labdane diterpenoid, (+)-larixol (1). In a two-step procedure, (+)-larixol (1) was converted into 14,15-bisnorlab-7-ene-6,13-dione (9), which

  13. A Novel Synthesis of (-)-10-epi-α-Cyperone

    Institute of Scientific and Technical Information of China (English)

    Li Jing FANG; Jin Chun CHEN; Guo Jun ZHENG; Yu Kun GUAN; Yu Lin LI

    2004-01-01

    An alternative route for the synthesis of (-)-10-epi-α-cyperone 1 starting from (+)- dihydrocarvone 2 is described by using an asymmetric Michael addition as a key step. The route features more efficiently and can be performed in large scale.

  14. Creating Simple Windchill Admin Tools Using Info*Engine

    Science.gov (United States)

    Jones, Corey; Kapatos, Dennis; Skradski, Cory

    2012-01-01

    Being a Windchill administrator often requires performing simple yet repetitive tasks on large sets of objects. These can include renaming, deleting, checking in, undoing checkout, and much more. This is especially true during a migration. Fortunately, PTC has provided a simple way to dynamically interact with Windchill using Info*Engine. This presentation will describe how to create simple Info*Engine tasks capable of saving Windchill 10.0 administrators hours of tedious work. It will also show how these tasks can be combined and displayed on a simple JSP page that acts as a "Windchill Administrator Dashboard/Toolbox". The attendee will learn some valuable tasks Info*Engine capable of performing. The attendee will gain a basic understanding of how to perform and implement Info*Engine tasks. The attendee will learn what's involved in creating a JSP page that displays Info*Engine tasks

  15. Bilateral contributions of the cerebellum to the complex motor tasks on EPI fMRI

    International Nuclear Information System (INIS)

    Chung, Eun Chul; Youn, Eun Kyung; Lee, Young Rae; Kim, Yoo Kyung; Park, Kee Duk

    1999-01-01

    To demonstrate activation signals within the cerebellar cortex and to determine the side of the cerebellar cortex eliciting activation signals in response to complex motor tasks, as seen on EPI fMRI. Seven right-handed subjects (M : F=3 : 4; mean age, 30.3 years) underwent repetitive finger apposition with the dominant right hand. Using a 1.5 T MRI scanner, EPI fMR images were obtained. MR parameters used for EPI fMRI were TR/TE/Flip angle : 0.96 msec/64msec/90 deg FOV 22cm, 128 X 128 matrix, 10 slices, 10mm thickness while those for SE T1 weighted localized images were TR/TE : 450/16, FOV 23cm, 256 X 256 matrix. The paradigm was three sets of alternate resting and moving fingers for six cycles, resulting in times of 360 seconds (10 slices X 15 EPI X 6 cycles = 900 images). Image processing involved the use of a 200mHz Dual Pentium PC with homemade software. T-testing (p < 0.005 approx.= p < 0.0005) and time series analysis were performed, and to verify the locations of activated regions, resulting images were analyzed in a color-coded overlay to reference T1-weighted spin echo coronal images. Percentage change in signal intensity (PCSI) was calculated from the processed data. All normal subjects showed significant activation signals in both the contralateral (left) primary motor cortex (PCSI = 3.12% 0.96) and ipsilateral (right) cerebellar cortex (PCSI = 3.09% ±1.14). Signal activation was detected in the contralateral supplemental motor area (2.91% ±0.82), and motor activation in the anterior upper half of the contralateral cerebellum (PCSI 2.50% ±0.69). The difference in activation signals between both sides of the cerebellar cortex was not statistically significant. All data were matched with time-series analysis. Bilateral cerebellar activation is associated with unilateral complex finger movements, as seen on fMRI. This result may support the recent neurological observation that the cerebellum may exert bilateral effects on motor performance

  16. Practical Synthesis of Pachastrissamine (Jaspine B), 2-epi-Pachastrissamine, and the 2-epi-Pyrrolidine Analogue.

    Science.gov (United States)

    Fujiwara, Tomoya; Liu, Bo; Niu, Wenqi; Hashimoto, Kazuki; Nambu, Hisanori; Yakura, Takayuki

    2016-01-01

    The practical syntheses of pachastrissamine (jaspine B), 2-epi-pachastrissamine, and the 2-epimer of the pyrrolidine analogue were accomplished via the stereoselective reduction of an allylketone derived from commercially available diethyl D-tartrate and the cross-metathesis of an allyltetrahydrofuran or allypyrrolidine with 1-tridecene as key steps.

  17. File list: Unc.PSC.20.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.EpiLC.bed ...

  18. File list: Unc.PSC.50.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074905,SRX1074908 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.EpiSC.bed ...

  19. File list: Unc.PSC.50.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.50.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.50.AllAg.EpiLC.bed ...

  20. File list: Unc.PSC.05.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074908,SRX1074905 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.EpiSC.bed ...

  1. File list: Unc.PSC.20.AllAg.EpiSC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.20.AllAg.EpiSC mm9 Unclassified Pluripotent stem cell EpiSC SRX1074917,SRX1...074908,SRX1074905 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.20.AllAg.EpiSC.bed ...

  2. File list: Unc.PSC.10.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.10.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.10.AllAg.EpiLC.bed ...

  3. File list: Unc.PSC.05.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available Unc.PSC.05.AllAg.EpiLC mm9 Unclassified Pluripotent stem cell EpiLC SRX1074910,SRX1...074907 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/Unc.PSC.05.AllAg.EpiLC.bed ...

  4. File list: InP.PSC.50.AllAg.EpiLC [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available InP.PSC.50.AllAg.EpiLC mm9 Input control Pluripotent stem cell EpiLC SRX823839,SRX5...5,SRX823838,SRX823831,SRX823826,SRX590324 http://dbarchive.biosciencedbc.jp/kyushu-u/mm9/assembled/InP.PSC.50.AllAg.EpiLC.bed ...

  5. [First year results of "APAAC infos services"].

    Science.gov (United States)

    Didi-Kouko Coulibaly, Judith; Aka Dago-Akribi, Hortense; Oyoua, Blandine; Koffi-Gnagne, Yolande; Adoubi, Innocent; Echimane, Kouassi Antoine

    2013-02-01

    In Ivory Coast, the APAAC association "Let us help persons living with cancer or affected by cancer", in French "Aidons les Personnes Atteintes ou Affectées par le Cancer" (APAAC), set up the first ivorian call center to support persons living with or affected by cancer and to inform population about cancer. To show the feasibility of such a service in a developing country and to present the first results. This helpline is, since January 28th, 2010, directly accessible to the population by a fixed phone number. The population can, with a local cost call, contact a specialists team (psychologist, adviser in help relation or doctor), in total confidentiality, every Thursday from 3 pm till 5 pm. Outside Thursdays, informations about cancer are available on vocal server 24 hours a day and seven days a week. Callers are welcomed by a message inviting them either to listen to a recorded message about cancer or about APAAC association or finally to speak to a specialist online. Retrospective study based on the statistics of the call center. Because of a problem arisen on the statistics software, our results carry only over the period from August to December, 2010. We had, during this period, 462 calls among which 23 in August, 58 in September, 67 in October, 230 in November and 84 in December. Reasons of the increasing of the figures are justify by the poster campaign in September and the communication around the service on television program in November. On these 462 calls, we had 35 real communications among whom 10 calls interrupted. The reason was the lack of call credit. The average of the call time was of 20 minutes for the conversations with the specialists. Three hundred and forty-three persons stopped to the welcome message, 341 (9%) listen information on the cancer, 27 (6%) listen information about the association. Sixteen persons wished to speak to specialists but were not regrettably able to make it because having called up except the hours of presence. Three

  6. Stem Cell Technology for (Epi)genetic Brain Disorders.

    Science.gov (United States)

    Riemens, Renzo J M; Soares, Edilene S; Esteller, Manel; Delgado-Morales, Raul

    2017-01-01

    Despite the enormous efforts of the scientific community over the years, effective therapeutics for many (epi)genetic brain disorders remain unidentified. The common and persistent failures to translate preclinical findings into clinical success are partially attributed to the limited efficiency of current disease models. Although animal and cellular models have substantially improved our knowledge of the pathological processes involved in these disorders, human brain research has generally been hampered by a lack of satisfactory humanized model systems. This, together with our incomplete knowledge of the multifactorial causes in the majority of these disorders, as well as a thorough understanding of associated (epi)genetic alterations, has been impeding progress in gaining more mechanistic insights from translational studies. Over the last years, however, stem cell technology has been offering an alternative approach to study and treat human brain disorders. Owing to this technology, we are now able to obtain a theoretically inexhaustible source of human neural cells and precursors in vitro that offer a platform for disease modeling and the establishment of therapeutic interventions. In addition to the potential to increase our general understanding of how (epi)genetic alterations contribute to the pathology of brain disorders, stem cells and derivatives allow for high-throughput drugs and toxicity testing, and provide a cell source for transplant therapies in regenerative medicine. In the current chapter, we will demonstrate the validity of human stem cell-based models and address the utility of other stem cell-based applications for several human brain disorders with multifactorial and (epi)genetic bases, including Parkinson's disease (PD), Alzheimer's disease (AD), fragile X syndrome (FXS), Angelman syndrome (AS), Prader-Willi syndrome (PWS), and Rett syndrome (RTT).

  7. 3D Hyperpolarized C-13 EPI with Calibrationless Parallel Imaging

    DEFF Research Database (Denmark)

    Gordon, Jeremy W.; Hansen, Rie Beck; Shin, Peter J.

    2018-01-01

    With the translation of metabolic MRI with hyperpolarized 13C agents into the clinic, imaging approaches will require large volumetric FOVs to support clinical applications. Parallel imaging techniques will be crucial to increasing volumetric scan coverage while minimizing RF requirements and tem...... strategies to accelerate and undersample hyperpolarized 13C data using 3D blipped EPI acquisitions and multichannel receive coils, and demonstrated its application in a human study of [1-13C]pyruvate metabolism....

  8. fMRI of the motor speech center using EPI

    International Nuclear Information System (INIS)

    Yu, In Kyu; Chang, Kee Hyun; Song, In Chan; Kim, Hong Dae; Seong, Su Ok; Jang, Hyun Jung; Han, Moon Hee; Lee, Sang Kun

    1998-01-01

    The purpose of this study is to evaluate the feasibility of functional MR imaging (fMRI) using the echo planar imaging (EPI) technique to map the motor speech center and to provide the basic data for motor speech fMRI during internal word generations. This study involved ten young, healthy, right-handed volunteers (M:F=8:2; age: 21-27); a 1.5T whole body scanner with multislice EPI was used. Brain activation was mapped using gradient echo single shot EPI (TR/TE of 3000/40, slice numbers 6, slice thicknesses mm, no interslice gap, matrix numbers 128 x 128, and FOV 30 x 30). The paradigm consisted of a series of alternating rest and activation tasks, repeated eight times. During the rest task, each of ten Korean nouns composed of two to four syllables was shown continuously every 3 seconds. The subjects were required to see the words but not to generate speech, whereas during the activation task, they were asked to internally generate as many words as possible from each of ten non-concrete one-syllabled Korean letters shown on the screen every 3 seconds. During an eight-minute period, a total of 960 axial images were acquired in each subject. Data were analyzed using the Z-score (p<0.05), and following color processing, the activated signals were overlapped on T1-weighted images. The location of the activated area, mean activated signal intensity were evaluated. The results of this study indicate that in most subjects, fMRI using EPI can effectively map the motor speech center. The data obtained may be useful for the clinical application of fMRI. (author). 34 refs., 3 tabs., 5 figs

  9. Double epi-illumination microscopy with separate visualization of two antigens: a combination of epi-polarization for immunogold-silver staining and epi-fluorescence for alkaline phosphatase staining

    NARCIS (Netherlands)

    van der Loos, C. M.; Becker, A. E.

    1994-01-01

    We present a method for an epi-illumination immunohistochemical double staining approach. The method combines the use of an immuno-alkaline phosphatase technique and the immunogold-silver technique, visualized with epifluorescence and epi-polarization illumination, respectively. Out of six tested

  10. Total synthesis of putative 11-epi-lyngbouilloside aglycon

    Directory of Open Access Journals (Sweden)

    Amandine Kolleth

    2016-08-01

    Full Text Available We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the 14-membered ring macrolactone and a late-stage side chain introduction via a Wittig olefination. Overall, the final product was obtained in 20 steps and 2% overall yield starting from commercially available 3-methyl-but-3-enol. Most importantly, the strategy employed is versatile enough to eventually allow us to complete the synthesis of the natural product and irrevocably confirm its structure.

  11. CityInfo Boards : a new marketing communications tool

    OpenAIRE

    Tähkäpää, Matti

    2012-01-01

    New CityInfo boards were introduced in December 2009. This project was executed in cooperation with City of Turku and Veikkaus. The objective of this pilot project was to clean up the cityscape as well as support the local sports and culture organizations that are organizing events in Turku. CityInfo boards are divided into three sections; top of the is reserved for welcome greeting of Turku, right side of the board has the logo of Veikkaus, and the left side has electronic screen with changi...

  12. Renal zoomed EPI-DWI with spatially-selective radiofrequency excitation pulses in two dimensions

    Energy Technology Data Exchange (ETDEWEB)

    He, Yong-Lan, E-mail: ylhe_526@163.com [Department of Radiology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing (China); Hausmann, Daniel, E-mail: daniel.hausmann@medma.uni-heidelberg.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim (Germany); Morelli, John N., E-mail: dr.john.morelli@gmail.com [St. John' s Medical Center, Tulsa, OK (United States); Attenberger, Ulrike I., E-mail: ulrike.attenberger@medma.uni-heidelberg.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim (Germany); Schoenberg, Stefan O., E-mail: stefan.schoenberg@umm.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim (Germany); Riffel, Philipp, E-mail: philipp.riffel@umm.de [Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim – Heidelberg University, Mannheim (Germany)

    2016-10-15

    Highlights: • Renal zoomed diffusion-weighted imaging with spatially-selective radiofrequency excitation pulses is feasible. • z-EPI offers considerable potential for mitigating the limitations of conventional EPI techniques. • z-EPI of kidney may lead to substantial image quality improvements with reduced artifacts. - Abstract: Purpose: To evaluate the feasibility and clinical robustness of zoomed diffusion-weighted echo planar imaging (z-EPI) relative to conventional single-shot EPI (c-EPI) for DWI of the kidneys. Materials and methods: This retrospective study was approved by the institutional research ethics board. 66 patients (median age 58.5 years ± 13.4, range 23–83 years, 45 men, 21 women) undergoing 3T (Magnetom Skyra{sup ®}, Siemens Healthcare, Erlangen, Germany) using a dynamic parallel transmit array (TimTX TrueShape, Siemens Healthcare, Erlangen, Germany) for renal MRI were included in this study. Both c-EPI and z-EPI images were obtained. For z-EPI, a two-dimensional spatially-selective radiofrequency (RF) pulse was applied for echo planar imaging with the FOV reduced by a factor of 3. Two radiologists, blinded to clinical data and scan parameters evaluated the images with respect to their diagnostic confidence, overall preference, overall image quality, delineation of the kidney, spatial distortion, and image blur. Sequences were compared using a paired Wilcoxon test. ADC values for the upper pole, mid-zone, lower pole of the normal kidneys were compared between sequences as well as ADC values for renal lesions, using a paired t-test. Results: With z-EPI, the kidney was significantly better delineated with sharper boundaries, less image blur and distortion, and overall better image quality relative to c-EPI (all p < 0.001). The z-EPI technique led to greater diagnostic confidence than c-EPI (p = 0.020). z-EPI was preferred to c-EPI in 60 cases (90.9%, 60/66). No statistically significant differences in the ADC values of renal parenchyma or

  13. Renal zoomed EPI-DWI with spatially-selective radiofrequency excitation pulses in two dimensions

    International Nuclear Information System (INIS)

    He, Yong-Lan; Hausmann, Daniel; Morelli, John N.; Attenberger, Ulrike I.; Schoenberg, Stefan O.; Riffel, Philipp

    2016-01-01

    Highlights: • Renal zoomed diffusion-weighted imaging with spatially-selective radiofrequency excitation pulses is feasible. • z-EPI offers considerable potential for mitigating the limitations of conventional EPI techniques. • z-EPI of kidney may lead to substantial image quality improvements with reduced artifacts. - Abstract: Purpose: To evaluate the feasibility and clinical robustness of zoomed diffusion-weighted echo planar imaging (z-EPI) relative to conventional single-shot EPI (c-EPI) for DWI of the kidneys. Materials and methods: This retrospective study was approved by the institutional research ethics board. 66 patients (median age 58.5 years ± 13.4, range 23–83 years, 45 men, 21 women) undergoing 3T (Magnetom Skyra ® , Siemens Healthcare, Erlangen, Germany) using a dynamic parallel transmit array (TimTX TrueShape, Siemens Healthcare, Erlangen, Germany) for renal MRI were included in this study. Both c-EPI and z-EPI images were obtained. For z-EPI, a two-dimensional spatially-selective radiofrequency (RF) pulse was applied for echo planar imaging with the FOV reduced by a factor of 3. Two radiologists, blinded to clinical data and scan parameters evaluated the images with respect to their diagnostic confidence, overall preference, overall image quality, delineation of the kidney, spatial distortion, and image blur. Sequences were compared using a paired Wilcoxon test. ADC values for the upper pole, mid-zone, lower pole of the normal kidneys were compared between sequences as well as ADC values for renal lesions, using a paired t-test. Results: With z-EPI, the kidney was significantly better delineated with sharper boundaries, less image blur and distortion, and overall better image quality relative to c-EPI (all p < 0.001). The z-EPI technique led to greater diagnostic confidence than c-EPI (p = 0.020). z-EPI was preferred to c-EPI in 60 cases (90.9%, 60/66). No statistically significant differences in the ADC values of renal parenchyma or of

  14. The impact of susceptibility gradients on cartesian and spiral EPI for BOLD fMRI

    DEFF Research Database (Denmark)

    Sangill, Ryan; Wallentin, Mikkel; Østergaard, Leif

    2006-01-01

    , with special emphasis on spiral EPI (spiral) and cartesian EPI (EPI) and their performance under influence of induced field gradients (SFGs) and stochastic noise. A numerical method for calculating synthetic MR images is developed and used to simulate BOLD fMRI experiments using EPI and spirals. The data...... is then examined for activation using a pixel-wise t test. Nine subjects are scanned with both techniques while performing a motor task. SPM99 is used for analysing the experimental data. The simulated spirals provide generally higher t scores at low SFGs but lose more strength than EPI at higher SFGs, where EPI...... activation is offset from the true position. In the primary motor area spirals provide significantly higher t scores (P SFG areas spirals provide stronger activation than...

  15. Episódios de cuidados: um conceito em saúde pública

    OpenAIRE

    Gentil,Lia; Vanasse,Alain; Xhignesse,Marianne

    2013-01-01

    INTRODUÇÃO: Esse artigo apresenta uma revisão da literatura sobre a definição de episódio de cuidados. O conceito de episódio de cuidados na pesquisa em serviços de saúde emergiu nos anos 60. Os episódios têm sido descritos em três perspectivas diferentes: a do paciente (episódio de mal estar), a do prestador do serviço (episódio de doença) e do seu financiador (episódio de cuidados). OBJETIVO: O principal objetivo desse estudo é apresentar uma revisão da literatura da definição operacional d...

  16. Infosüsteemi audit on juhtimisvahend / Kristjan Hiiemaa

    Index Scriptorium Estoniae

    Hiiemaa, Kristjan

    2005-01-01

    Ettevõtte infosüsteemide auditeerimise vajalikkusest, võimalustest, tulemustest. Äririski hindamisest ning töökohtade vastavusest ohutus- ja ergonoomianõuetele. Lisa: Heatasemeline IS audit võiks koosneda järgmistest osadest

  17. Infosüsteemi audit on juhtimisvahend / Kristjan Hiiemaa

    Index Scriptorium Estoniae

    Hiiemaa, Kristjan

    2005-01-01

    Nõuetele vastavuse kontrollist ja hinnangu andmisest auditeeritava organisatsiooni infosüsteemile. Äririski hindamisest ning töökohtade vastavusest ohutus- ja ergonoomianõuetele. Lisad: IS auditi protsess; Hea ja piisava katvusega IS audit koosneb järgmistest osadest; Mida annab IS audit firma tippjuhile

  18. Juhtimise infosüsteem loob kaoses korra / Erle Kildjer

    Index Scriptorium Estoniae

    Kildjer, Erle

    2006-01-01

    Juhtimisinfosüsteemides on võimalik näidata ainult otsuse jaoks vajalikke andmeid ilma muu infomürata. Vt. samas: Infosüsteemi abil saab juht prognoosida müüki; Helina Tuvike. Reval Hotels suudab ennustada tubade täituvust

  19. InfoPoems: Various Topics | | South African Family Practice

    African Journals Online (AJOL)

    Topics: 1.Medications help passage of kidney stones. 2.Limited data on probiotics to prevent antibiotic induced diarrhea in kids. 3.Best way to perform lumbar puncture and analyze results. 4.Acupuncture effective for long-term back pain relief. InfoPOEMs® keep you current and answers your clinical medicine questions at ...

  20. InfoQUEST: An Online Catalog for Small Libraries.

    Science.gov (United States)

    Campbell, Bonnie

    1984-01-01

    InfoQUEST is a microcomputer-based online public access catalog, designed for the small library handling file sizes up to 25,000 records. Based on the IBM-PC, or compatible machines, the system will accept downloading, in batch mode, of records from the library's file on the UTLAS Catalog Support System. (Author/EJS)

  1. EpiBasket: how e-commerce tools can improve epidemiological preparedness.

    Science.gov (United States)

    Xing, Weijia; Hejblum, Gilles; Valleron, Alain-Jacques

    2013-10-31

    Should an emerging infectious disease outbreak or an environmental disaster occur, the collection of epidemiological data must start as soon as possible after the event's onset. Questionnaires are usually built de novo for each event, resulting in substantially delayed epidemiological responses that are detrimental to the understanding and control of the event considered. Moreover, the public health and/or academic institution databases constructed with responses to different questionnaires are usually difficult to merge, impairing necessary collaborations. We aimed to show that e-commerce concepts and software tools can be readily adapted to enable rapid collection of data after an infectious disease outbreak or environmental disaster. Here, the 'customers' are the epidemiologists, who fill their shopping 'baskets' with standardised questions. For each epidemiological field, a catalogue of questions is constituted by identifying the relevant variables based on a review of the published literature on similar circumstances. Each question is tagged with information on its source papers. Epidemiologists can then tailor their own questionnaires by choosing appropriate questions from this catalogue. The software immediately provides them with ready-to-use forms and online questionnaires. All databases constituted by the different EpiBasket users are interoperable, because the corresponding questionnaires are derived from the same corpus of questions. A proof-of-concept prototype was developed for Knowledge, Attitudes and Practice (KAP) surveys, which is one of the fields of the epidemiological investigation frequently explored during, or after, an outbreak or environmental disaster. The catalogue of questions was initiated from a review of the KAP studies conducted during or after the 2003 severe acute respiratory syndrome epidemic. Rapid collection of standardised data after an outbreak or environmental disaster can be facilitated by transposing the e-commerce paradigm

  2. EpiBasket: how e-commerce tools can improve epidemiological preparedness

    Science.gov (United States)

    Xing, Weijia; Hejblum, Gilles; Valleron, Alain-Jacques

    2013-01-01

    Background Should an emerging infectious disease outbreak or an environmental disaster occur, the collection of epidemiological data must start as soon as possible after the event's onset. Questionnaires are usually built de novo for each event, resulting in substantially delayed epidemiological responses that are detrimental to the understanding and control of the event considered. Moreover, the public health and/or academic institution databases constructed with responses to different questionnaires are usually difficult to merge, impairing necessary collaborations. We aimed to show that e-commerce concepts and software tools can be readily adapted to enable rapid collection of data after an infectious disease outbreak or environmental disaster. Here, the ‘customers’ are the epidemiologists, who fill their shopping ‘baskets’ with standardised questions. Methods For each epidemiological field, a catalogue of questions is constituted by identifying the relevant variables based on a review of the published literature on similar circumstances. Each question is tagged with information on its source papers. Epidemiologists can then tailor their own questionnaires by choosing appropriate questions from this catalogue. The software immediately provides them with ready-to-use forms and online questionnaires. All databases constituted by the different EpiBasket users are interoperable, because the corresponding questionnaires are derived from the same corpus of questions. Results A proof-of-concept prototype was developed for Knowledge, Attitudes and Practice (KAP) surveys, which is one of the fields of the epidemiological investigation frequently explored during, or after, an outbreak or environmental disaster. The catalogue of questions was initiated from a review of the KAP studies conducted during or after the 2003 severe acute respiratory syndrome epidemic. Conclusion Rapid collection of standardised data after an outbreak or environmental disaster can be

  3. Teletandem e episódios relacionados a cultura

    Directory of Open Access Journals (Sweden)

    João Antonio TELLES

    2015-12-01

    Full Text Available Teletandem é um contexto telecolaborativo de aprendizagem que envolve dois falantes nativos (ou competentes de diferentes línguas. Utilizando o Skype, cada participante faz papel de aluno por meia hora, falando e praticando a língua do seu parceiro. Este artigo enfoca a interação em teletandem entre dois estudantes universitários - uma brasileira e um estadunidense. Na primeira parte, sustentamos nossa pressuposição de que os participantes do teletandem compartilham informações acerca das respectivas culturas. Na segunda, apresentamos cinco dimensões do conceito de cultura, definimos aprendizagem cultural e propomos uma unidade de análise para interpretação dos dados - o episódio relacionado a cultura. Por fim, sugerimos diretrizes para futuras pesquisas relacionadas à aprendizagem de línguas e culturas em contextos colaborativos on-line.

  4. InfoGallery: Informative Arts Services for Physical Library Spaces

    DEFF Research Database (Denmark)

    Grønbæk, Kaj; Rohde, Anne; Sundararajah, Balasuthas

    2006-01-01

    Much focus in digital libraries research has been devoted to new online services rather than services for the visitors in the physical library. This paper describes InfoGallery, which is a web-based infrastructure for enriching the physical library space with informative art "exhibitions......" of digital library material and other relevant information, such as RSS news streams, event announcements etc. InfoGallery presents information in an aesthetically attractive manner on a variety of surfaces in the library, including cylindrical displays and floors. The infrastructure consists of a server...... structure, an editor application and a variety of display clients. The paper discusses the design of the infrastructure and its utilization of RSS, podcasts and manually edited news. Applications in the library domain are described and the experiences are discussed....

  5. CT-Info: uma visão a fundo

    Directory of Open Access Journals (Sweden)

    Daniele Nogueira Milani

    2011-11-01

    Full Text Available O presente estudo adota uma metodologia diferenciada de avaliação dos fundos setoriais e tem por objetivo realizar uma dissecção da dinâmica de funcionamento e dos impactos do CT-Info à luz do que está estabelecido como seu foco, que é fomentar projetos em empresas brasileiras do setor de informática. Para tanto, foi realizada uma investigação que buscou responder a três questões fundamentais: qual o perfil das empresas que obtiveram recursos concedidos pelo CT-Info? Como se desenvolveu a dinâmica de utilização desses recursos? Qual a motivação para que empresas recorram ou não ao instrumento? Por um lado, os resultados apontam para uma captura do instrumento pelo complexo acadêmico-universitário. Por outro, para as poucas empresas beneficiárias, apesar das dificuldades burocráticas, os resultados obtidos foram muito expressivos.This articles adopts a differentiated methodology for evaluating sectoral funds, and its aim is to analyze the functioning and the impacts of CT-Info in what regards to its focus: to support projects in Brazilian information technology firms. To accomplish this goal, the research tried to answer three fundamental questions: what is the profile of the firms supported by CT-Info? How was the dynamics of utilization of the resources? What was the motivation for firms to use or not to use the instrument? In one hand, results point to a capture of the instrument by the Academy. On the other hand, for the few supported firms, despite bureaucratic difficulties, the obtained results were very important.

  6. Zoomed EPI-DWI of the head and neck with two-dimensional, spatially-selective radiofrequency excitation pulses

    Energy Technology Data Exchange (ETDEWEB)

    Riffel, Philipp; Michaely, Henrik J.; Attenberger, Ulrike I.; Schoenberg, Stefan O.; Haneder, Stefan [University Medical Center Mannheim, Medical Faculty Mannheim - Heidelberg University, Institute of Clinical Radiology and Nuclear Medicine, Mannheim (Germany); Morelli, John N. [Johns Hopkins University School of Medicine, Russell H. Morgan Department of Radiology and Radiological Science, Baltimore, MD (United States); Pfeuffer, Josef [Siemens Healthcare Sector, Application Development, Erlangen (Germany)

    2014-10-15

    To evaluate the feasibility of zoomed diffusion-weighted EPI (z-EPI) in the head and neck in a healthy volunteer population and to compare to conventional single-shot EPI (c-EPI). Nine volunteers were included in this prospective, IRB-approved study. Examinations were performed on a 3 T-MR system equipped with a two-channel, fully-dynamic parallel transmit array. The acquired sequences consisted of a T2w-TSE, a c-EPI, and two z-EPI acquisitions. For quantitative assessment of distortion artefacts, DW images were fused with T2-TSE images. Misregistration of DW images with T2-TSE images was assessed in the cervical spine. For qualitative assessment, two readers ranked c-EPI and z-EPI sequences in terms of susceptibility artefacts, image blur, and overall imaging preference. ADC values of several anatomical regions were calculated and compared between sequences. Mean maximum distortion with the c-EPI was 5.9 mm ± 1.6 mm versus 2.4 mm ± 1 mm (p < 0.05) with z-EPI. Both readers found more blur and susceptibility artefacts in every case with c-EPI. No statistically significant differences in calculated ADC values were observed. z-EPI of the head and neck leads to substantial image quality improvements relative to c-EPI due to a reduction in susceptibility artefacts and image blur. (orig.)

  7. Clinical application of EPI diffusion weighted image (DWI) for ischemic brain disease

    International Nuclear Information System (INIS)

    Zenke, Kiichiro; Kusunoki, Katsusuke; Saito, Masahiro; Sadamoto, Kazuhiko; Sakaki, Saburo; Kumon, Yoshiaki; Nagasawa, Kiyoshi

    1999-01-01

    Diffusion-weighted magnetic resonance image (DWI) with Echo Planar imaging (EPI) techniques were utilized in 74 consecutive patients who were suspected or diagnosed as having occlusive cerebrovascular diseases. Of three EPI-DWI techniques-single shot DWI, multi-shot DWI and isotropic DWI-, isotropic DWI was the most useful study for diagnosing occlusive cerebro-vascular disease. EPI-DWI could identify fresh infarction, even small cortical infarctions, in the setting of multiple high intensity lesions shown by T2 weighted image (T2WI), and could detect infarcted lesions early after the onset. In the patients whose lesions were not revealed on the initial EPI-DWIs, new infarcted lesion were not found on later MRIs, and their symptoms disappeared completely. High intensity lesions observed on EPI-DWIs mostly decreased signal intensities about 2 weeks after the onset, and the intensities of lesions in the gray matter were reduced earlier than those in the white matter. (author)

  8. Implementation and Application of PSF-Based EPI Distortion Correction to High Field Animal Imaging

    Directory of Open Access Journals (Sweden)

    Dominik Paul

    2009-01-01

    Full Text Available The purpose of this work is to demonstrate the functionality and performance of a PSF-based geometric distortion correction for high-field functional animal EPI. The EPI method was extended to measure the PSF and a postprocessing chain was implemented in Matlab for offline distortion correction. The correction procedure was applied to phantom and in vivo imaging of mice and rats at 9.4T using different SE-EPI and DWI-EPI protocols. Results show the significant improvement in image quality for single- and multishot EPI. Using a reduced FOV in the PSF encoding direction clearly reduced the acquisition time for PSF data by an acceleration factor of 2 or 4, without affecting the correction quality.

  9. SoilInfo App: global soil information on your palm

    Science.gov (United States)

    Hengl, Tomislav; Mendes de Jesus, Jorge

    2015-04-01

    ISRIC ' World Soil Information has released in 2014 and app for mobile de- vices called 'SoilInfo' (http://soilinfo-app.org) and which aims at providing free access to the global soil data. SoilInfo App (available for Android v.4.0 Ice Cream Sandwhich or higher, and Apple v.6.x and v.7.x iOS) currently serves the Soil- Grids1km data ' a stack of soil property and class maps at six standard depths at a resolution of 1 km (30 arc second) predicted using automated geostatistical mapping and global soil data models. The list of served soil data includes: soil organic carbon (), soil pH, sand, silt and clay fractions (%), bulk density (kg/m3), cation exchange capacity of the fine earth fraction (cmol+/kg), coarse fragments (%), World Reference Base soil groups, and USDA Soil Taxonomy suborders (DOI: 10.1371/journal.pone.0105992). New soil properties and classes will be continuously added to the system. SoilGrids1km are available for download under a Creative Commons non-commercial license via http://soilgrids.org. They are also accessible via a Representational State Transfer API (http://rest.soilgrids.org) service. SoilInfo App mimics common weather apps, but is also largely inspired by the crowdsourcing systems such as the OpenStreetMap, Geo-wiki and similar. Two development aspects of the SoilInfo App and SoilGrids are constantly being worked on: Data quality in terms of accuracy of spatial predictions and derived information, and Data usability in terms of ease of access and ease of use (i.e. flexibility of the cyberinfrastructure / functionalities such as the REST SoilGrids API, SoilInfo App etc). The development focus in 2015 is on improving the thematic and spatial accuracy of SoilGrids predictions, primarily by using finer resolution covariates (250 m) and machine learning algorithms (such as random forests) to improve spatial predictions.

  10. Advanced Epi Tools for Gallium Nitride Light Emitting Diode Devices

    Energy Technology Data Exchange (ETDEWEB)

    Patibandla, Nag; Agrawal, Vivek

    2012-12-01

    Over the course of this program, Applied Materials, Inc., with generous support from the United States Department of Energy, developed a world-class three chamber III-Nitride epi cluster tool for low-cost, high volume GaN growth for the solid state lighting industry. One of the major achievements of the program was to design, build, and demonstrate the world’s largest wafer capacity HVPE chamber suitable for repeatable high volume III-Nitride template and device manufacturing. Applied Materials’ experience in developing deposition chambers for the silicon chip industry over many decades resulted in many orders of magnitude reductions in the price of transistors. That experience and understanding was used in developing this GaN epi deposition tool. The multi-chamber approach, which continues to be unique in the ability of the each chamber to deposit a section of the full device structure, unlike other cluster tools, allows for extreme flexibility in the manufacturing process. This robust architecture is suitable for not just the LED industry, but GaN power devices as well, both horizontal and vertical designs. The new HVPE technology developed allows GaN to be grown at a rate unheard of with MOCVD, up to 20x the typical MOCVD rates of 3{micro}m per hour, with bulk crystal quality better than the highest-quality commercial GaN films grown by MOCVD at a much cheaper overall cost. This is a unique development as the HVPE process has been known for decades, but never successfully commercially developed for high volume manufacturing. This research shows the potential of the first commercial-grade HVPE chamber, an elusive goal for III-V researchers and those wanting to capitalize on the promise of HVPE. Additionally, in the course of this program, Applied Materials built two MOCVD chambers, in addition to the HVPE chamber, and a robot that moves wafers between them. The MOCVD chambers demonstrated industry-leading wavelength yield for GaN based LED wafers and industry

  11. Research and realization of info-net security controlling system

    Science.gov (United States)

    Xu, Tao; Zhang, Wei; Li, Xuhong; Wang, Xia; Pan, Wenwen

    2017-03-01

    The thesis introduces some relative concepts about Network Cybernetics, and we design and realize a new info-net security controlling system based on Network Cybernetics. The system can control the endpoints, safely save files, encrypt communication, supervise actions of users and show security conditions, in order to realize full-scale security management. At last, we simulate the functions of the system. The results show, the system can ensure the controllability of users and devices, and supervise them real-time. The system can maximize the security of the network and users.

  12. Distortion Correction in Fetal EPI Using Non-Rigid Registration With a Laplacian Constraint.

    Science.gov (United States)

    Kuklisova-Murgasova, Maria; Lockwood Estrin, Georgia; Nunes, Rita G; Malik, Shaihan J; Rutherford, Mary A; Rueckert, Daniel; Hajnal, Joseph V

    2018-01-01

    Geometric distortion induced by the main B0 field disrupts the consistency of fetal echo planar imaging (EPI) data, on which diffusion and functional magnetic resonance imaging is based. In this paper, we present a novel data-driven method for simultaneous motion and distortion correction of fetal EPI. A motion-corrected and reconstructed T2 weighted single shot fast spin echo (ssFSE) volume is used as a model of undistorted fetal brain anatomy. Our algorithm interleaves two registration steps: estimation of fetal motion parameters by aligning EPI slices to the model; and deformable registration of EPI slices to slices simulated from the undistorted model to estimate the distortion field. The deformable registration is regularized by a physically inspired Laplacian constraint, to model distortion induced by a source-free background B0 field. Our experiments show that distortion correction significantly improves consistency of reconstructed EPI volumes with ssFSE volumes. In addition, the estimated distortion fields are consistent with fields calculated from acquired field maps, and the Laplacian constraint is essential for estimation of plausible distortion fields. The EPI volumes reconstructed from different scans of the same subject were more consistent when the proposed method was used in comparison with EPI volumes reconstructed from data distortion corrected using a separately acquired B0 field map.

  13. epiPATH: an information system for the storage and management of molecular epidemiology data from infectious pathogens

    Directory of Open Access Journals (Sweden)

    González-Candelas Fernando

    2007-04-01

    Full Text Available Abstract Background Most research scientists working in the fields of molecular epidemiology, population and evolutionary genetics are confronted with the management of large volumes of data. Moreover, the data used in studies of infectious diseases are complex and usually derive from different institutions such as hospitals or laboratories. Since no public database scheme incorporating clinical and epidemiological information about patients and molecular information about pathogens is currently available, we have developed an information system, composed by a main database and a web-based interface, which integrates both types of data and satisfies requirements of good organization, simple accessibility, data security and multi-user support. Results From the moment a patient arrives to a hospital or health centre until the processing and analysis of molecular sequences obtained from infectious pathogens in the laboratory, lots of information is collected from different sources. We have divided the most relevant data into 12 conceptual modules around which we have organized the database schema. Our schema is very complete and it covers many aspects of sample sources, samples, laboratory processes, molecular sequences, phylogenetics results, clinical tests and results, clinical information, treatments, pathogens, transmissions, outbreaks and bibliographic information. Communication between end-users and the selected Relational Database Management System (RDMS is carried out by default through a command-line window or through a user-friendly, web-based interface which provides access and management tools for the data. Conclusion epiPATH is an information system for managing clinical and molecular information from infectious diseases. It facilitates daily work related to infectious pathogens and sequences obtained from them. This software is intended for local installation in order to safeguard private data and provides advanced SQL-users the

  14. Info.cern.ch returns to the Web

    CERN Document Server

    2006-01-01

    First web address is reincarnated as a historical reference on the birth of the Web. Tim Berners-Lee, inventor of the Web, with one of the first Web pages on his computer. CERN invites you to take a virtual trip back in time and have a look at what the very first URL, which led to a revolution of the way we communicate and share information, was all about. The original web server, whose address was info.cern.ch, centred on information regarding the WorldWideWeb (WWW) project. Visitors could learn more about hypertext, technical details for creating one's own webpage, and even an explanation on how to search the Web for information-something 5 year-olds of today have mastered since it all started 17 years ago. Now info.cern.ch has been re-launched with a much brighter façade and a focus on the ideas that inspired this new wave of technology. The first browser created by Tim Berners-Lee, inventor of the Web, contained just about everything we see today on a web browser, including graphics, menus, layouts and...

  15. IDG's InfoWorld names 100 most innovative corporate IT solutions for 2007

    CERN Multimedia

    2007-01-01

    "IDG's InfoWorld has announced the winners of its InfoWorld 100 Awards. The annual awards honor IT projects that demonstrate the most creative use of cutting-edge technologies to further their business goals." (2 pages)

  16. Clinical application of multi-shot diffusion EPI in neurological disease

    International Nuclear Information System (INIS)

    Ishihara, Tetsuya; Hirata, Koichi; Kubo, Jin; Yamazaki, Kaoru; Sato, Toshihiko

    1998-01-01

    Using the multi-shot EPI method we investigated the clinical application of diffusion weighted imaging (DWI) in the diagnosis of neurological disease. The multi-shot method provided better susceptibility artifact-free DWI than the single-shot method particularly in the region of the posterior cranial fossa. DWI using the multi-shot EPI method readily shows the pyramidal tract extending from the internal capsule to the brainstems which is inaccessible by the conventional single-shot EPI method, and providing three-dimensional and distinct images of pyramidal tract changes in amyotrophic lateral sclerosis or cerebral infarction with pyramidal tract disturbance. Our findings suggest that the use of DWI with the multi-shot EPI method would provide a technique for the easy diagnosis and evaluation of various neurological diseases. (author)

  17. Clinical application of multi-shot diffusion EPI in neurological disease

    Energy Technology Data Exchange (ETDEWEB)

    Ishihara, Tetsuya; Hirata, Koichi; Kubo, Jin; Yamazaki, Kaoru [Dokkyo Univ., Mibu, Tochigi (Japan). School of Medicine; Sato, Toshihiko

    1998-05-01

    Using the multi-shot EPI method we investigated the clinical application of diffusion weighted imaging (DWI) in the diagnosis of neurological disease. The multi-shot method provided better susceptibility artifact-free DWI than the single-shot method particularly in the region of the posterior cranial fossa. DWI using the multi-shot EPI method readily shows the pyramidal tract extending from the internal capsule to the brainstems which is inaccessible by the conventional single-shot EPI method, and providing three-dimensional and distinct images of pyramidal tract changes in amyotrophic lateral sclerosis or cerebral infarction with pyramidal tract disturbance. Our findings suggest that the use of DWI with the multi-shot EPI method would provide a technique for the easy diagnosis and evaluation of various neurological diseases. (author)

  18. Performance of EPI diodes as dosimeters for photon beam radiotherapy

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Thais C. dos; Bizetto, Cesar A., E-mail: ccbueno@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Neves-Junior, Wellington F.P.; Haddad, Cecilia M.K. [Hospital Sirio Libanes (HSL), Sao Paulo, SP (Brazil); Goncalves, Josemary A.C.; Bueno, Carmen C. [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil); Pontificia Universidade Catolica de Sao Paulo (PUC-SP), SP (Brazil)

    2011-07-01

    In this work we present the preliminary results about the performance of an epitaxial (EPI) diode as on-line dosimeter for photon beam radiotherapy. The diode used was processed at University of Hamburg on n-type 75 {mu}m thick epitaxial silicon layer grown on a highly doped n-type 300 {mu}m thick Czochralski (Cz) silicon substrate. The measurements were performed with a diode which not received any type of pre-dose. In order to use this device as a dosimeter, it was enclosed in a black polymethylmethacrylate (PMMA) probe. The diode was connected to an electrometer Keithley 6517B in the photovoltaic mode. During all measurements, the diode was held between PMMA plates, placed at 10.0 cm depth and centered in a radiation field of 10 x 10 cm{sup 2}, with the source-to-surface distance (SSD) kept at 100 cm. The short-term repeatability was measured with photon beams of 6 and 18 MV energy by registering five consecutive current signals for the same radiation dose. The current signals induced showed good instantaneous repeatability of the diode, characterized by a smallest coefficient of variation (CV) of 0.21%. Furthermore, the dose-response curves of the diode were quite linear with the highest charge sensitivity achieved of 5.0 {mu}C/Gy. It worth noting that still remains to be investigated the pre-dose influence on epitaxial silicon diode response in radiotherapy photon beam dosimetry, the long term stability and the radiation hardness of these diodes for absorbed doses higher than that investigated in this work. All these studies are under way. (author)

  19. Software engineering

    CERN Document Server

    Sommerville, Ian

    2010-01-01

    The ninth edition of Software Engineering presents a broad perspective of software engineering, focusing on the processes and techniques fundamental to the creation of reliable, software systems. Increased coverage of agile methods and software reuse, along with coverage of 'traditional' plan-driven software engineering, gives readers the most up-to-date view of the field currently available. Practical case studies, a full set of easy-to-access supplements, and extensive web resources make teaching the course easier than ever.

  20. Visual outcomes after Epi-LASIK and PRK for low and moderate myopia.

    Science.gov (United States)

    Sia, Rose K; Coe, Charles D; Edwards, Jayson D; Ryan, Denise S; Bower, Kraig S

    2012-01-01

    To evaluate visual outcomes following epi-LASIK compared to photorefractive keratectomy (PRK). Of a total 294 patients aged ≥21 years, 145 (290 eyes) underwent epi-LASIK and 149 (298 eyes) underwent PRK for low to moderate myopia or myopic astigmatism. Epi-LASIK was performed with the Amadeus II epikeratome (Abbott Medical Optics) and PRK with the Amoils rotary epithelial brush (Innovative Excimer Solutions). All ablations were performed using the same excimer laser system. Outcome measures included intraoperative complications, corneal reepithelialization, postoperative pain, uncorrected distance visual acuity (UDVA), manifest refraction spherical equivalent (MRSE), corrected distance visual acuity (CDVA), corneal haze, and quality of vision. Mean preoperative MRSE was -2.97±1.19 diopters (D) for epi-LASIK versus -2.95±1.06 D for PRK. Complete reepithelialization was achieved by postoperative day 4 in 46.9% of epi-LASIK eyes versus 92.4% of PRK eyes, with superior UDVA at postoperative day 1 in the PRK group (P=.002). Using Fisher exact test, a significantly higher percentage of epi-LASIK eyes compared to PRK eyes achieved 20/15 or better at 1 month (25.8% vs 17.8%, P=.031), 3 months (62.3% vs 49.3%, P=.004), 6 months (77.1% vs 57.9%, Pvs 61.9%, P=.002). A change in MRSE >0.50 D occurred in 8.4% of epi-LASIK eyes within the 3- and 12-month interval versus 17.7% of PRK eyes (P=.04). No differences were noted between the two procedures in CDVA or clinically significant haze. Epi-LASIK showed superior refractive efficacy and stability but required more time for wound healing, resulting in inferior early visual outcomes and a tendency to overcorrect higher refractive errors compared to PRK. Both treatments were safe and comparable in terms of pain and haze formation. Copyright 2012, SLACK Incorporated.

  1. Generation of iPSC line epiHUVEC from human umbilical vein endothelial cells

    Directory of Open Access Journals (Sweden)

    Peggy Matz

    2015-11-01

    Full Text Available Human umbilical vein endothelial cells (HUVECs were used to generate the iPSC line epiHUVEC employing a combination of three episomal-based plasmids expressing OCT4, SOX2, NANOG, LIN28, c-MYC and KLF4. Pluripotency was confirmed both in vivo and in vitro. The transcriptome profile of epiHUVEC and the human embryonic stem cell line — H1 have a Pearson correlation of 0.899.

  2. Long term results of Epi-LASIK and LASEK for myopia.

    Science.gov (United States)

    Yuksel, Nilay; Bilgihan, Kamil; Hondur, Ahmet M; Yildiz, Burcin; Yuksel, Erdem

    2014-06-01

    To evaluate the long term clinical and confocal results of mechanical (Epi-LASIK) versus alcohol-assisted laser epithelial keratomileusis (LASEK) for correction of myopia. Gazi University Medical School, Department of Ophthalmology, Ankara, Turkey. Retrospective study. Twenty-two eyes treated with LASEK and twenty eyes treated with Epi-LASIK were evaluated with a mean follow-up duration of 45 months. Mechanical separation of the epithelium was performed with Lasitome epithelial separator, and alcohol-assisted separation with 25s application of 18% alcohol. Laser ablation was performed with the ESIRIS laser. All patients were examined daily until epithelial closure; at 1, 3, 6, and 12 months; and every year subsequently. Main outcome measures were uncorrected visual acuity (UCVA), manifest refraction, haze, and gray scale value in confocal microscopy, efficacy and safety indexes. Preoperative myopic spherical equivalent refraction was -4.65 ± 1.74 D in the LASEK and -3.87 ± 1.30 D in the Epi-LASIK-treated eyes (p=0.36). Of both LASEK and Epi-LASIK-treated eyes, 95% achieved 20/25 or better final UCVA. The grade of haze and mean gray scale value in confocal microscopy were similar in LASEK and Epi-LASIK-treated eyes at all postoperative periods. The efficacy index was 0.94 in LASEK group and 0.96 in Epi-LASIK group (p=0.44). The safety index was 1.01 in LASEK group and 1.02 in Epi-LASIK group (p=0.42). Both LASEK and Epi-LASIK offer safe and effective correction of myopia in the long term. Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.

  3. A prospective bilateral comparison of epi-LASIK and LASEK for myopia.

    Science.gov (United States)

    Hondur, Ahmet; Bilgihan, Kamil; Hasanreisoglu, Berati

    2008-11-01

    To compare the clinical and confocal microscopic results of mechanical (epi-LASIK) versus alcohol-assisted laser epithelial keratomileusis (LASEK) for the correction of myopia. Twenty-five patients with myopia received epi-LASIK in one eye and LASEK in the other. The difference of spherical equivalent refraction of myopia and astigmatism was less than 1.00 diopter (D) in two eyes of each case. Mechanical separation of the epithelium was performed with the Lasitome epithelial separator and alcohol-assisted separation with 25 second application of 18% alcohol. Ablation was performed with the ESIRIS laser. Patients were seen daily until epithelial closure, and at 1, 3, 6, and 12 months. Time to epithelial healing, uncorrected visual acuity (UCVA), manifest refraction, haze, and grey scale value in confocal microscopy were recorded. Preoperative myopic spherical equivalent refraction was -3.95+/-1.49 D in the epi-LASIK and -3.91+/-1.39 D in the LASEK-treated eyes. The mean time to epithelial healing was slightly longer after epi-LASIK (4.86+/-0.64 vs 4.18+/-0.58 days). Of both epi-LASIK and LASEK-treated eyes, 92% achieved 20/20 or better UCVA and were within +/-0.50 D of emmetropia at 12 months. The grade of haze and mean grey scale value in confocal microscopy were similar in epi-LASIK and LASEK-treated eyes at all postoperative periods. One eye treated with epi-LASIK suffered a minor stromal cut. Epi-LASIK and LASEK offer effective correction of myopia with comparable results at 1 year.

  4. EpiReumaPt: how to perform a national population based study - a practical guide

    OpenAIRE

    Gouveia, Nélia; Rodrigues, Ana M.; Ramiro, Sofia; Machado, Pedro; Da Costa, Leonor Pereira; Mourão, Ana Filipa; Silva, Inês; Rego, Tânia; Laires, Pedro; André, Rui; Mauricio, Luís; Romeu, José Carlos; Tavares, Viviana; Cerol, Jorge; Canhão, Helena

    2015-01-01

    BACKGROUND: The aim of this article was to describe and discuss several strategies and standard operating procedures undertaken in the EpiReumaPt study - which was the first Portuguese, national, cross-sectional population-based study of Rheumatic and Musculoskeletal Diseases (RMD). METHODS: The technical procedures, legal issues, management and practical questions were studied, analyzed and discussed with relevant stakeholders. During the 1st phase of EpiReumaPt the coordination team and Cen...

  5. DisEpi: Compact Visualization as a Tool for Applied Epidemiological Research.

    Science.gov (United States)

    Benis, Arriel; Hoshen, Moshe

    2017-01-01

    Outcomes research and evidence-based medical practice is being positively impacted by proliferation of healthcare databases. Modern epidemiologic studies require complex data comprehension. A new tool, DisEpi, facilitates visual exploration of epidemiological data supporting Public Health Knowledge Discovery. It provides domain-experts a compact visualization of information at the population level. In this study, DisEpi is applied to Attention-Deficit/Hyperactivity Disorder (ADHD) patients within Clalit Health Services, analyzing the socio-demographic and ADHD filled prescription data between 2006 and 2016 of 1,605,800 children aged 6 to 17 years. DisEpi's goals facilitate the identification of (1) Links between attributes and/or events, (2) Changes in these relationships over time, and (3) Clusters of population attributes for similar trends. DisEpi combines hierarchical clustering graphics and a heatmap where color shades reflect disease time-trends. In the ADHD context, DisEpi allowed the domain-expert to visually analyze a snapshot summary of data mining results. Accordingly, the domain-expert was able to efficiently identify that: (1) Relatively younger children and particularly youngest children in class are treated more often, (2) Medication incidence increased between 2006 and 2011 but then stabilized, and (3) Progression rates of medication incidence is different for each of the 3 main discovered clusters (aka: profiles) of treated children. DisEpi delivered results similar to those previously published which used classical statistical approaches. DisEpi requires minimal preparation and fewer iterations, generating results in a user-friendly format for the domain-expert. DisEpi will be wrapped as a package containing the end-to-end discovery process. Optionally, it may provide automated annotation using calendar events (such as policy changes or media interests), which can improve discovery efficiency, interpretation, and policy implementation.

  6. Info-tsunami: surviving the storm with data quality probes

    Directory of Open Access Journals (Sweden)

    Philip Brown

    2003-12-01

    Full Text Available As a result of the rapid expansion of electronically available clinical knowledge, clinicians are faced with potential information overload (info-tsunami. The use of data quality probes (DQPs in primary care can encourage clinicians' awareness of, and improvement in, data quality entry over time. DQPs can also highlight areas of potential error or omission as well as good practice, which can impact directly upon the quality of patient care. In this paper, five specific conditions have been subjected to the use of a series of DQPs over a five-year period in order to assess and measure the performance of different initiatives on the quality of data capture and patient care.

  7. EpiCollect: linking smartphones to web applications for epidemiology, ecology and community data collection.

    Directory of Open Access Journals (Sweden)

    David M Aanensen

    2009-09-01

    Full Text Available Epidemiologists and ecologists often collect data in the field and, on returning to their laboratory, enter their data into a database for further analysis. The recent introduction of mobile phones that utilise the open source Android operating system, and which include (among other features both GPS and Google Maps, provide new opportunities for developing mobile phone applications, which in conjunction with web applications, allow two-way communication between field workers and their project databases.Here we describe a generic framework, consisting of mobile phone software, EpiCollect, and a web application located within www.spatialepidemiology.net. Data collected by multiple field workers can be submitted by phone, together with GPS data, to a common web database and can be displayed and analysed, along with previously collected data, using Google Maps (or Google Earth. Similarly, data from the web database can be requested and displayed on the mobile phone, again using Google Maps. Data filtering options allow the display of data submitted by the individual field workers or, for example, those data within certain values of a measured variable or a time period.Data collection frameworks utilising mobile phones with data submission to and from central databases are widely applicable and can give a field worker similar display and analysis tools on their mobile phone that they would have if viewing the data in their laboratory via the web. We demonstrate their utility for epidemiological data collection and display, and briefly discuss their application in ecological and community data collection. Furthermore, such frameworks offer great potential for recruiting 'citizen scientists' to contribute data easily to central databases through their mobile phone.

  8. EpiCollect: linking smartphones to web applications for epidemiology, ecology and community data collection.

    Science.gov (United States)

    Aanensen, David M; Huntley, Derek M; Feil, Edward J; al-Own, Fada'a; Spratt, Brian G

    2009-09-16

    Epidemiologists and ecologists often collect data in the field and, on returning to their laboratory, enter their data into a database for further analysis. The recent introduction of mobile phones that utilise the open source Android operating system, and which include (among other features) both GPS and Google Maps, provide new opportunities for developing mobile phone applications, which in conjunction with web applications, allow two-way communication between field workers and their project databases. Here we describe a generic framework, consisting of mobile phone software, EpiCollect, and a web application located within www.spatialepidemiology.net. Data collected by multiple field workers can be submitted by phone, together with GPS data, to a common web database and can be displayed and analysed, along with previously collected data, using Google Maps (or Google Earth). Similarly, data from the web database can be requested and displayed on the mobile phone, again using Google Maps. Data filtering options allow the display of data submitted by the individual field workers or, for example, those data within certain values of a measured variable or a time period. Data collection frameworks utilising mobile phones with data submission to and from central databases are widely applicable and can give a field worker similar display and analysis tools on their mobile phone that they would have if viewing the data in their laboratory via the web. We demonstrate their utility for epidemiological data collection and display, and briefly discuss their application in ecological and community data collection. Furthermore, such frameworks offer great potential for recruiting 'citizen scientists' to contribute data easily to central databases through their mobile phone.

  9. SOFTWARE OPEN SOURCE, SOFTWARE GRATIS?

    Directory of Open Access Journals (Sweden)

    Nur Aini Rakhmawati

    2006-01-01

    Full Text Available Normal 0 false false false IN X-NONE X-NONE MicrosoftInternetExplorer4 Berlakunya Undang – undang Hak Atas Kekayaan Intelektual (HAKI, memunculkan suatu alternatif baru untuk menggunakan software open source. Penggunaan software open source menyebar seiring dengan isu global pada Information Communication Technology (ICT saat ini. Beberapa organisasi dan perusahaan mulai menjadikan software open source sebagai pertimbangan. Banyak konsep mengenai software open source ini. Mulai dari software yang gratis sampai software tidak berlisensi. Tidak sepenuhnya isu software open source benar, untuk itu perlu dikenalkan konsep software open source mulai dari sejarah, lisensi dan bagaimana cara memilih lisensi, serta pertimbangan dalam memilih software open source yang ada. Kata kunci :Lisensi, Open Source, HAKI

  10. The modified CKD-EPI equation may be not more accurate than CKD-EPI equation in determining glomerular filtration rate in Chinese patients with chronic kidney disease.

    Science.gov (United States)

    Xie, Peng; Huang, Jian-Min; Li, Ying; Liu, Huai-Jun; Qu, Yan

    2017-06-01

    To investigate the application of the new modified Chronic Kidney Disease Epidemiology Collaboration (mCKD-EPI) equation developed by Liu for the measurement of glomerular filtration rate (GFR) in Chinese patients with chronic kidney disease (CKD) and to evaluate whether this modified form is more accurate than the original one in clinical practice. GFR was determined simultaneously by 3 methods: (a) 99m Tc-diethylene triamine pentaacetic acid ( 99m Tc-DTPA) dual plasma sample clearance method (mGFR), which was used as the reference standard; (b) CKD-EPI equation (eGFRckdepi); (c) modified CKD-EPI equation (eGFRmodified). Concordance correlation and Passing-Bablok regression were used to compare the validity of eGFRckdepi and eGFRmodified. Bias, precision and accuracy were compared to identify which equation showed the better performance in determining GFR. A total of 170 patients were enrolled. Both eGFRckdepi and eGFRmodified correlated well with mGFR (concordance correlation coefficient 0.90 and 0.74, respectively) and the Passing-Bablok regression equation of eGFRckdepi and eGFRmodified against mGFR was mGFR = 0.37 + 1.04 eGFRckdepi and -49.25 + 1.74 eGFRmodified, respectively. In terms of bias, precision and 30 % accuracy, eGFRmodified showed a worse performance compared to eGFRckdepi, in the whole cohort. The new modified CKD-EPI equation cannot replace the original CKD-EPI equation in determining GFR in Chinese patients with CKD.

  11. Software Epistemology

    Science.gov (United States)

    2016-03-01

    in-vitro decision to incubate a startup, Lexumo [7], which is developing a commercial Software as a Service ( SaaS ) vulnerability assessment...LTS Label Transition System MUSE Mining and Understanding Software Enclaves RTEMS Real-Time Executive for Multi-processor Systems SaaS Software ...as a Service SSA Static Single Assignment SWE Software Epistemology UD/DU Def-Use/Use-Def Chains (Dataflow Graph)

  12. Software reliability

    CERN Document Server

    Bendell, A

    1986-01-01

    Software Reliability reviews some fundamental issues of software reliability as well as the techniques, models, and metrics used to predict the reliability of software. Topics covered include fault avoidance, fault removal, and fault tolerance, along with statistical methods for the objective assessment of predictive accuracy. Development cost models and life-cycle cost models are also discussed. This book is divided into eight sections and begins with a chapter on adaptive modeling used to predict software reliability, followed by a discussion on failure rate in software reliability growth mo

  13. Computer software.

    Science.gov (United States)

    Rosenthal, L E

    1986-10-01

    Software is the component in a computer system that permits the hardware to perform the various functions that a computer system is capable of doing. The history of software and its development can be traced to the early nineteenth century. All computer systems are designed to utilize the "stored program concept" as first developed by Charles Babbage in the 1850s. The concept was lost until the mid-1940s, when modern computers made their appearance. Today, because of the complex and myriad tasks that a computer system can perform, there has been a differentiation of types of software. There is software designed to perform specific business applications. There is software that controls the overall operation of a computer system. And there is software that is designed to carry out specialized tasks. Regardless of types, software is the most critical component of any computer system. Without it, all one has is a collection of circuits, transistors, and silicone chips.

  14. EpiJen: a server for multistep T cell epitope prediction

    Directory of Open Access Journals (Sweden)

    Guan Pingping

    2006-03-01

    Full Text Available Abstract Background The main processing pathway for MHC class I ligands involves degradation of proteins by the proteasome, followed by transport of products by the transporter associated with antigen processing (TAP to the endoplasmic reticulum (ER, where peptides are bound by MHC class I molecules, and then presented on the cell surface by MHCs. The whole process is modeled here using an integrated approach, which we call EpiJen. EpiJen is based on quantitative matrices, derived by the additive method, and applied successively to select epitopes. EpiJen is available free online. Results To identify epitopes, a source protein is passed through four steps: proteasome cleavage, TAP transport, MHC binding and epitope selection. At each stage, different proportions of non-epitopes are eliminated. The final set of peptides represents no more than 5% of the whole protein sequence and will contain 85% of the true epitopes, as indicated by external validation. Compared to other integrated methods (NetCTL, WAPP and SMM, EpiJen performs best, predicting 61 of the 99 HIV epitopes used in this study. Conclusion EpiJen is a reliable multi-step algorithm for T cell epitope prediction, which belongs to the next generation of in silico T cell epitope identification methods. These methods aim to reduce subsequent experimental work by improving the success rate of epitope prediction.

  15. Using a Computer Module to Teach Use of the EpiPen®

    Directory of Open Access Journals (Sweden)

    Amandeep Singh Rai

    2011-11-01

    Full Text Available Background: The medical literature suggests that patients and physicians are deficient in their ability to use a self-injectable epinephrine device (EpiPen® for management of anaphylaxis. This study aims to determine whether a computer module is an effective tool for the instruction of a technical skill to medical trainees. Methods: We conducted a two group comparison study of 35 Post-Graduate Year 1 and 2 Family Medicine residents. Participants were instructed on use of the EpiPen® using either a written module or a computer module. Participants were evaluated on use of the EpiPen® using standardized objective outcome measures by a blinded assessor. Assessments took place prior to and following instruction, using the assigned learning modality. Results: There were 34 participants who completed the study. Both groups demonstrated significant improvement in demonstrating use of the EpiPen® following training (p <0.001 for both. A significant post-training difference favouring the computer module learners over the written module learners was observed (p = 0.035. However, only 53% and 18% of candidates (computer module and written module, respectively were able to correctly perform all of the checklist steps. Conclusion: While our findings suggest computer modules represent an effective modality for teaching use of the EpiPen® to medical trainees, the low number of candidates who were able to perform all the checklist items regardless of modality needs to be addressed.

  16. Usability: a critical success factor for managing change in the clinical info-structure.

    Science.gov (United States)

    Kay, S

    2005-06-01

    There can be no doubt that the clinical info-structure is being significantly enriched with the deployment of new systems throughout the health sector. From a technological perspective, the initial emphasis has been mainly on functionality and only latterly on the usability of these clinical information systems. However, the large scale and rapid pace of the changes being wrought in the health sector will have a major impact on clinicians and patients, not least in how they interact with the technology. Therefore, it is not only hardware and software but people-ware, too, that needs to be actively managed; not simply a one-off functional specification but an ongoing, complex relationship. Usability is the human factor that encompasses the ethical, educational, and evaluative aspects of design. There is also a strong case for regarding usability of clinical information systems as a key critical success factor for the management of change within the health-care domain. In particular, the relationship between usability, and education and training is examined.

  17. Integrated analysis of the molecular action of Vorinostat identifies epi-sensitised targets for combination therapy.

    Science.gov (United States)

    Hay, Jodie F; Lappin, Katrina; Liberante, Fabio; Kettyle, Laura M; Matchett, Kyle B; Thompson, Alexander; Mills, Ken I

    2017-09-15

    Several histone deacetylase inhibitors including Vorinostat have received FDA approval for the treatment of haematological malignancies. However, data from these trials indicate that Vorinostat has limited efficacy as a monotherapy, prompting the need for rational design of combination therapies. A number of epi-sensitised pathways, including sonic hedgehog (SHH), were identified in AML cells by integration of global patterns of histone H3 lysine 9 (H3K9) acetylation with transcriptomic analysis following Vorinostat-treatment. Direct targeting of the SHH pathway with SANT-1, following Vorinostat induced epi-sensitisation, resulted in synergistic cell death of AML cells. In addition, xenograft studies demonstrated that combination therapy induced a marked reduction in leukemic burden compared to control or single agents. Together, the data supports epi-sensitisation as a potential component of the strategy for the rational development of combination therapies in AML.

  18. Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging.

    Science.gov (United States)

    Giacomelli, Michael G; Husvogt, Lennart; Vardeh, Hilde; Faulkner-Jones, Beverly E; Hornegger, Joachim; Connolly, James L; Fujimoto, James G

    2016-01-01

    We derive a physically realistic model for the generation of virtual transillumination, white light microscopy images using epi-fluorescence measurements from thick, unsectioned tissue. We demonstrate this technique by generating virtual transillumination H&E images of unsectioned human breast tissue from epi-fluorescence multiphoton microscopy data. The virtual transillumination algorithm is shown to enable improved contrast and color accuracy compared with previous color mapping methods. Finally, we present an open source implementation of the algorithm in OpenGL, enabling real-time GPU-based generation of virtual transillumination microscopy images using conventional fluorescence microscopy systems.

  19. Virtual Hematoxylin and Eosin Transillumination Microscopy Using Epi-Fluorescence Imaging.

    Directory of Open Access Journals (Sweden)

    Michael G Giacomelli

    Full Text Available We derive a physically realistic model for the generation of virtual transillumination, white light microscopy images using epi-fluorescence measurements from thick, unsectioned tissue. We demonstrate this technique by generating virtual transillumination H&E images of unsectioned human breast tissue from epi-fluorescence multiphoton microscopy data. The virtual transillumination algorithm is shown to enable improved contrast and color accuracy compared with previous color mapping methods. Finally, we present an open source implementation of the algorithm in OpenGL, enabling real-time GPU-based generation of virtual transillumination microscopy images using conventional fluorescence microscopy systems.

  20. Investigation of the C-3-epi-25(OH)D3 of 25-hydroxyvitamin D3 in urban schoolchildren.

    Science.gov (United States)

    Berger, Samantha E; Van Rompay, Maria I; Gordon, Catherine M; Goodman, Elizabeth; Eliasziw, Misha; Holick, Michael F; Sacheck, Jennifer M

    2018-03-01

    The physiological relevance C-3 epimer of 25-hydroxyvitamin D (3-epi-25(OH)D) is not well understood among youth. The objective of this study was to assess whether demographic/physiologic characteristics were associated with 3-epi-25(OH)D 3 concentrations in youth. Associations between 3-epi-25(OH)D 3 and demographics and between 3-epi-25(OH)D 3 , total 25-hydroxyvitamin (25(OH)D) (25(OH)D 2 + 25(OH)D 3 ), total cholesterol, high-density lipoprotein, low-density lipoprotein, and triglycerides were examined in racially/ethnically diverse schoolchildren (n = 682; age, 8-15 years) at Boston-area urban schools. Approximately 50% of participants had detectable 3-epi-25(OH)D 3 (range 0.95-3.95 ng/mL). The percentage of 3-epi-25(OH)D 3 of total 25(OH)D ranged from 2.5% to 17.0% (median 5.5%). Males were 38% more likely than females to have detectable 3-epi-25(OH)D 3 concentrations. Both Asian and black race/ethnicity were associated with lower odds of having detectable 3-epi-25(OH)D 3 compared with non-Hispanic white children (Asian vs. white, odds ratio (OR) 0.28, 95% confidence interval (CI) 0.14-0.53; black vs. white, OR 0.38, 95%CI 0.23-0.63, p 30 ng/mL) 25(OH)D concentration was associated with higher odds of having detectable 3-epi-25(OH)D 3 than having an inadequate (<20 ng/mL) concentration (OR 4.78, 95%CI 3.23-6.94 or OR 14.10, 95%CI 7.10-28.0, respectively). There was no association between 3-epi-25(OH)D 3 and blood lipids. However, when considering 3-epi-25(OH)D 3 as a percentage of total 25(OH)D, total cholesterol was lower in children with percent 3-epi-25(OH)D 3 above the median (mean difference -7.1 mg/dL, p = 0.01). In conclusion, among schoolchildren, sex, race/ethnicity, and total serum 25(OH)D concentration is differentially associated with 3-epi-25(OH)D. The physiological relevance of 3-epi-25(OH)D 3 may be related to the 3-epi-25(OH)D 3 as a percentage of total 25(OH)D and should be considered in future investigations.

  1. APLIKASI INFO HALAL MENGGUNAKAN BARCODE SCANNER UNTUK SMARTPHONE ANDROID

    Directory of Open Access Journals (Sweden)

    Beki Subeki

    2016-05-01

    Full Text Available Abstract – In the production and trade of food products in the era of globalization, people are consuming, especially Muslims need to be given the knowledge, information and access to adequate in order to obtain the correct information about the halal status of products bought. The use of barcode scanners halal product information using the mobile platform is effective and useful for the public to find out information on a product. Barcode scanners can be read by optical scanners called barcode readers or scanned from an image by special software. In Indonesia, most mobile phones have the scanning software for 2D codes, and similar devices available via smartphone.   Keywords : Barcode Scanner, Mobile Platform, Halal Products, Smartphone     Abstrak - Dalam kegiatan produksi dan perdagangan produk pangan di era globalisasi ini, masyarakat yang mengkonsumsi, khususnya umat islam perlu diberikan pengetahuan tentang kehalalan produk, informasi dan akses yang memadai agar memperoleh informasi yang benar tentang status kehalalan produk yang dibelinya. Penggunaan barcode scanner informasi produk halal dengan menggunakan mobile platform dinilai cukup efektif dan berguna bagi masyarakat luas untuk mengetahui informasi sebuah produk. Barcode scanner dapat dibaca oleh pemindai optik yang disebut pembaca kode batang atau dipindai dari sebuah gambar oleh perangkat lunak khusus. Di Indonesia, kebanyakan telepon genggam memiliki perangkat lunak pemindai untuk kode 2D, dan perangkat sejenis tersedia melalui smartphone.   Kata Kunci: Barcode Scanner, Mobile Platform, Produk Halal, Smartphone

  2. Software Innovation

    DEFF Research Database (Denmark)

    Rose, Jeremy

      Innovation is the forgotten key to modern systems development - the element that defines the enterprising engineer, the thriving software firm and the cutting edge software application.  Traditional forms of technical education pay little attention to creativity - often encouraging overly...

  3. Software engineering

    CERN Document Server

    Sommerville, Ian

    2016-01-01

    For courses in computer science and software engineering The Fundamental Practice of Software Engineering Software Engineering introduces readers to the overwhelmingly important subject of software programming and development. In the past few years, computer systems have come to dominate not just our technological growth, but the foundations of our world's major industries. This text seeks to lay out the fundamental concepts of this huge and continually growing subject area in a clear and comprehensive manner. The Tenth Edition contains new information that highlights various technological updates of recent years, providing readers with highly relevant and current information. Sommerville's experience in system dependability and systems engineering guides the text through a traditional plan-based approach that incorporates some novel agile methods. The text strives to teach the innovators of tomorrow how to create software that will make our world a better, safer, and more advanced place to live.

  4. Remediating cultural services in Second Life: The case of Info Island DK

    DEFF Research Database (Denmark)

    Heilesen, Simon

    2009-01-01

    In 2007, Info Island DK was created as a virtual library in Second Life. This is an account of how library services of the physical library and the net library were remediated into a 3-D virtual world. The Info Island DK library was not widely adopted by any of the intended target groups, even if...

  5. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan

    NARCIS (Netherlands)

    Soofi, S.B.; Haq, I.U.; Khan, M.I.; Siddiqui, M.B.; Mirani, M.; Tahir, R.; Hussain, I.; Puri, M.K.; Suhag, Z.H.; Khowaja, A.R.; Lasi, A.R.; Clemens, J.D.; Favorov, M.; Ochiai, R.L.; Bhutta, Z.A.

    2012-01-01

    BACKGROUND: Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI) provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school

  6. Beyond Ribosomal Binding: The Increased Polarity and Aberrant Molecular Interactions of 3-epi-deoxynivalenol

    Directory of Open Access Journals (Sweden)

    Yousef I. Hassan

    2016-09-01

    Full Text Available Deoxynivalenol (DON is a secondary fungal metabolite and contaminant mycotoxin that is widely detected in wheat and corn products cultivated around the world. Bio-remediation methods have been extensively studied in the past two decades and promising ways to reduce DON-associated toxicities have been reported. Bacterial epimerization of DON at the C3 carbon was recently reported to induce a significant loss in the bio-toxicity of the resulting stereoisomer (3-epi-DON in comparison to the parental compound, DON. In an earlier study, we confirmed the diminished bio-potency of 3-epi-DON using different mammalian cell lines and mouse models and mechanistically attributed it to the reduced binding of 3-epi-DON within the ribosomal peptidyl transferase center (PTC. In the current study and by inspecting the chromatographic behavior of 3-epi-DON and its molecular interactions with a well-characterized enzyme, Fusarium graminearum Tri101 acetyltransferase, we provide the evidence that the C3 carbon epimerization of DON influences its molecular interactions beyond the abrogated PTC binding.

  7. Fast, accurate and automatic ancient nucleosome and methylation maps with epiPALEOMIX

    DEFF Research Database (Denmark)

    Hanghøj, Kristian; Seguin, Andaine; Schubert, Mikkel

    2016-01-01

    of CTCF binding regions can be used to help data authentication. Our work, including epiPALEOMIX, opens for further investigations of ancient epigenomes through time especially aimed at tracking possible epigenetic changes during major evolutionary, environmental, socioeconomic, and cultural shifts....

  8. The effect of the diterpene 5-epi-icetexone on the cell cycle of Trypanosoma cruzi.

    NARCIS (Netherlands)

    Lozano, E.; Barrera, P.; Tonn, C.; Nieto, M.; Sartor, T.; Sosa, M.A.

    2012-01-01

    Numerous natural compounds have been used against Trypanosoma cruzi, the causative agent of Chagas' disease. Here, we studied the effect of the diterpene 5-epi-icetexone on growth and morphology of parasites synchronized with hydroxyurea, at different periods of time after removal of the nucleotide.

  9. The EpiCom Survey-Registries Across Europe, Epidemiological Research and Beyond

    DEFF Research Database (Denmark)

    Gordon, Hannah; Langholz, Ebbe

    2017-01-01

    The 2015 EpiCom survey evaluated population, patient, and research registries across Europe. Information was collected from 38 countries. The registries included those falling within the remit of national statistics, hospital databases, twin and multiplex registries, inflammatory bowel disease [IBD...

  10. Curative effect observation of n-flap and off-flap EPi-LASIK in ametropia

    Directory of Open Access Journals (Sweden)

    Chao Liu

    2015-11-01

    Full Text Available AIM:To observe the clinical effect of on-flap and off-flap epipolis laser in situ keratomileusis(EPi-LASIKin ametropia.METHODS: Sixty-eight myopia patients(136 eyesreceiving surgical treatment were selected and divided into research group and control group according to different therapies. The patients in research group adopted off-flap EPi-LASIK and those in control group adopted on-flap EPi-LASIK. The index like uncorrected visual acuity, diopter and Haze of two groups before surgery, 1wk, 1 and 4mo after surgery was observed. RESULTS: One month after surgery, the uncorrected visual acuity of research group was 1.33±0.22 while that of control group was 1.22±0.19(PPPCONCLUSION:On-flap and off-flap EPi-LASIK are safe and effective surgery approaches in the clinical treatment of ametropia. The presence of corneal epithelial flap has a certain effect in the postoperative clinical outcome at early stage. The impact will be gradually reduced over time.

  11. Comparative study of Epi-LASIK and LASIK for myopic astigmatism

    Directory of Open Access Journals (Sweden)

    Jiao Chen

    2013-11-01

    Full Text Available AIM: To analyze the effects of epipolis laser in situ keratomileusis(Epi-LASIKand laser in situ keratomileusis(LASIKfor treatment of myopic astigmatism. METHODS: For treatment of myopic astigmatism, 32 patients(64 eyestreated by Epi-LASIK and 63 patients(126 eyesreceived LASIK. By their degree of astigmatism, the eyes were divided into Group Ⅰ(-0.25~-2.75DC and Group Ⅱ(-3.0~-5.0DC. During the 6-month follow-up, the early effects of the two operations were observed and compared in terms of uncorrected visual acuity(UCVA, best corrected visual acuity(BCVA, residual astigmatism, corneal healing, intraocular pressure(IOP, corneal topography. RESULTS: In Group Ⅱ, UCVA better than 20/20 was achieved in 87.5% of the eyes subjected to Epi-LASIK and in 63.3% of the eyes subjected to LASIK, with significant difference between them(χ2=4.055, Pt=2.672, Pt=2.234, PCONCLUSION: For treatment of high astigmatism(≥-3.00D, Epi-LASIK is more effective and predictive than LASIK.

  12. EpiScanGIS: an online geographic surveillance system for meningococcal disease

    Directory of Open Access Journals (Sweden)

    Albert Jürgen

    2008-07-01

    Full Text Available Abstract Background Surveillance of infectious diseases increasingly relies on Geographic Information Systems (GIS. The integration of pathogen fine typing data in dynamic systems and visualization of spatio-temporal clusters are a technical challenge for system development. Results An online geographic information system (EpiScanGIS based on open source components has been launched in Germany in May 2006 for real time provision of meningococcal typing data in conjunction with demographic information (age, incidence, population density. Spatio-temporal clusters of disease detected by computer assisted cluster analysis (SaTScan™ are visualized on maps. EpiScanGIS enables dynamic generation of animated maps. The system is based on open source components; its architecture is open for other infectious agents and geographic regions. EpiScanGIS is available at http://www.episcangis.org, and currently has 80 registered users, mostly from the public health service in Germany. At present more than 2,900 cases of invasive meningococcal disease are stored in the database (data as of June 3, 2008. Conclusion EpiScanGIS exemplifies GIS applications and early-warning systems in laboratory surveillance of infectious diseases.

  13. Comparison of CKD-EPI versus MDRD and Cockcroft-Gault ...

    African Journals Online (AJOL)

    2016-12-15

    Dec 15, 2016 ... being during the management of HbSS patients. Sickle cell anaemia is a ... Uche and Osegbe: CKD-EPI estimated GFR in stable HbSS patients. 817. Nigerian ..... Older age has been identified as a socio‑demographic factor .... S. Effects of posture on creatinine clearance and urinary protein excretion in ...

  14. Comparison of Epidrum, Epi-Jet, and Loss of Resistance syringe ...

    African Journals Online (AJOL)

    Background: Identifying the epidural space is essential during epidural anesthesia (EA). Pressure of the epidural space in pregnancy is higher than that in nonpregnant woman. Loss of resistance (LOR) method is the most commonly preferred method for identifying the epidural space. Epidrum and Epi-Jet are recently ...

  15. Roles of epi-anecic taxa of earthworms in the organic matter recycling

    Science.gov (United States)

    Hoeffner, Kevin; Monard, Cécile; Santonja, Mathieu; Pérès, Guénola; Cluzeau, Daniel

    2017-04-01

    Given their impact on soil functioning and their interactions with soil organisms, earthworms contribute to the recycling of organic matter and participate significantly in the numerous ecosystem services provided by soils. Most studies on the role of earthworms in organic matter recycling were conducted at the level of the four functional groups (epigeic, epi-anecic, anecic strict and endogeic), but their effects at taxa level remain largely unknown. Still, within a functional group, anatomic and physiologic earthworm taxa traits are different, which should impact organic matter recycling. This study aims at determining, under controlled conditions, epi-anecic taxa differences in (i) leaf litter mass loss, (ii) assimilation and (iii) impact on microorganisms communities implied in organic matter degradation. In seperate microcosms, we chose 4 epi anecic taxa (Lumbricus rubellus, Lumbricus festivus, Lumbricus centralis and Lumbricus terrestris). Each taxon was exposed separately to leaves of three different plants (Holcus lanatus, Lolium perenne and Corylus avellana). In the same microcosm, leaves of each plant was both placed on the surface and buried 10cm deep. The experiment lasted 10 days for half of the samples and 20 days for the second half. Microorganisms communities were analysed using TRFLP in each earthworm taxon burrow walls at 20 days. We observed differences between epi-anecic taxa depending on species of plant and the duration of the experiment. Results are discussed taking into account physical and chemical properties of these 3 trophic resources (e.g. C/N ratio, phenolic compounds, percentage of lignin and cellulose...).

  16. Software requirements

    CERN Document Server

    Wiegers, Karl E

    2003-01-01

    Without formal, verifiable software requirements-and an effective system for managing them-the programs that developers think they've agreed to build often will not be the same products their customers are expecting. In SOFTWARE REQUIREMENTS, Second Edition, requirements engineering authority Karl Wiegers amplifies the best practices presented in his original award-winning text?now a mainstay for anyone participating in the software development process. In this book, you'll discover effective techniques for managing the requirements engineering process all the way through the development cy

  17. Role of EPI in diagnosing cavernous hemangioma and small HCC : comparison with fast T2-weighted MR Imaging

    International Nuclear Information System (INIS)

    Kim, Suk; Lee, Jun Woo; Kim, Chang Won; Jung, Hyun Woo; Choi, Sang Yoel; Lee, Suck Hong; Kim, Byung Soo

    1998-01-01

    The purpose of this study is to compare single-shot echo-planar MR imaging (EPI) with breath-hold fast T2-weighted imaging (HASTE or Turbo spin-echo T2WI) for evaluation of the role of EPI in distinguishing small hepatocellular carcinoma from cavernous hemangioma. We retrospectively evaluated MR images of 35 patients (21 cases of small HCC and 14 cases of cavernous hemangioma). EPI and breath-hold fast T2WI images were obtained and compared on the basis of lesion detection sensitivity, lesion-to-liver signal intensity ratio (SIR), contrast ratio (CR), and lesion-to-liver contrast to noise ratio (CNR). For the detection of small HCC, the sensitivity of EPI and breath-hold fast T2WI were equal in 14 of 21 cases (71.4%). The detection sensitivity of cavernous hemangioma with EPI and breath-hold fast T2WI was 100 % (14/14). Mean SIR on breath-hold fast T2WI was 2.02 ± 0.45 for small HCC and 3.65 ± 0.97 for cavernous hemangioma; on EPI, the corresponding figures were 2.91 ± 0.57 for cavernous hemangioma; On EPI, the figures obtained were 2.27 ± 0.52 and 6.26 ± 2.19, respectively. Mean CNR on breath-hold fast T2WI was 14.24 ± 4.098 for small HCC and 50.28 ± 10.96 for cavernous hemangioma, while on EPI, the corresponding figures were 13.84 ± 3.02 and 45.44 ± 11.21. In detecting focal hepatic mass, the sensitivity of EPI and breath-hold fast T2WI are comparable for the diagnosis of small HCC and cavernous hemangioma, EPI can provided additional information. (author). 20 refs., 2 tabs., 4 figs

  18. Epi-LASIK e PRK: um ano de estudo comparativo em olhos contralaterais

    Directory of Open Access Journals (Sweden)

    Francisco Penteado Crestana

    2013-08-01

    Full Text Available OBJETIVO: Comparar as técnicas de PRK e Epi-LASIK com relação à recuperação visual e sintomatologia pós-operatória. MÉTODOS: Série de casos intervencionista que incluiu 38 olhos de 19 pacientes com miopia até 5DE e astigmatismo até 1DC. Foram selecionados pacientes com erros refracionais semelhantes nos dois olhos, realizando-se, no mesmo tempo cirúrgico, PRK em um olho e Epi-LASIK no olho contralateral. Os pacientes foram acompanhados por um ano, avaliando-se a eficácia refracional e grau de desconforto pós-operatório. RESULTADOS: Durante as primeiras 12 horas, 79,9% dos pacientes (p=0,0003 referiram dor mais intensa no olho operado com a técnica Epi-LASIK. Após 24 horas, 63,2% dos pacientes (p=0,012 ainda referiam mais dor neste olho e apenas 10,5% no olho contralateral. A acuidade visual não corrigida foi melhor nos olhos do grupo PRK no primeiro dia (p=0,034. Nos demais dias não houve diferença significativa entre os grupos. Houveopacidade corneana grau 0,5 (Fantes em três olhos do grupo PRK e em dois no grupo Epi-LASIK. CONCLUSÃO: Ambos os grupos apresentaram resultado visual refracional satisfatório, porém o grupo Epi-LASIK apresentou maior desconforto no pós-operatório imediato.

  19. Effect of EPI-743 on the clinical course of the mitochondrial disease Leber hereditary optic neuropathy.

    Science.gov (United States)

    Sadun, Alfredo A; Chicani, Carlos Filipe; Ross-Cisneros, Fred N; Barboni, Piero; Thoolen, Martin; Shrader, William D; Kubis, Kenneth; Carelli, Valerio; Miller, Guy

    2012-03-01

    To evaluate the safety and efficacy of a new therapeutic agent, EPI-743, in Leber hereditary optic neuropathy (LHON) using standard clinical, anatomic, and functional visual outcome measures. Open-label clinical trial. University medical center. Patients  Five patients with genetically confirmed LHON with acute loss of vision were consecutively enrolled and treated with the experimental therapeutic agent EPI-743 within 90 days of conversion. Intervention  During the course of the study, 5 consecutive patients received EPI-743, by mouth, 3 times daily (100-400 mg per dose). Treatment effect was assessed by serial measurements of anatomic and functional visual indices over 6 to 18 months, including Snellen visual acuity, retinal nerve fiber layer thickness measured by optical coherence tomography, Humphrey visual fields (mean decibels and area with 1-log unit depression), and color vision. Treatment effect in this clinical proof of principle study was assessed by comparison of the prospective open-label treatment group with historical controls. Of 5 subjects treated with EPI-743, 4 demonstrated arrest of disease progression and reversal of visual loss. Two patients exhibited a total recovery of visual acuity. No drug-related adverse events were recorded. In a small open-label trial, EPI-743 arrested disease progression and reversed vision loss in all but 1 of the 5 consecutively treated patients with LHON. Given the known natural history of acute and rapid progression of LHON resulting in chronic and persistent bilateral blindness, these data suggest that the previously described irreversible priming to retinal ganglion cell loss may be reversed.

  20. Software Reviews.

    Science.gov (United States)

    Dwyer, Donna; And Others

    1989-01-01

    Reviewed are seven software packages for Apple and IBM computers. Included are: "Toxicology"; "Science Corner: Space Probe"; "Alcohol and Pregnancy"; "Science Tool Kit Plus"; Computer Investigations: Plant Growth"; "Climatrolls"; and "Animal Watch: Whales." (CW)

  1. Software Reviews.

    Science.gov (United States)

    Davis, Shelly J., Ed.; Knaupp, Jon, Ed.

    1984-01-01

    Reviewed is computer software on: (1) classification of living things, a tutorial program for grades 5-10; and (2) polynomial practice using tiles, a drill-and-practice program for algebra students. (MNS)

  2. Software Reviews.

    Science.gov (United States)

    Miller, Anne, Ed.; Radziemski, Cathy, Ed.

    1988-01-01

    Three pieces of computer software are described and reviewed: HyperCard, to build and use varied applications; Iggy's Gnees, for problem solving with shapes in grades kindergarten-two; and Algebra Shop, for practicing skills and problem solving. (MNS)

  3. Uso da sequência FLAIR-EPI na análise da esclerose mesial temporal EPI-FLAIR sequence in the evaluation of mesial temporal sclerosis

    Directory of Open Access Journals (Sweden)

    Marcos Alberto da Costa Machado Júnior

    2001-06-01

    Full Text Available O objetivo deste estudo é analisar as alterações morfológicas e de intensidade de sinal das regiões hipocampais em pacientes, com epilepsia temporal fármaco-resistente. Para tal, estudamos 8 pacientes com esclerose mesial temporal, utilizando aparelhagem de RM de 1,5T, com sequências Spin Eco - SE, Fast Spin Eco - FSE, Fluid Atenuation Inversion Recovery, com Eco Planar Imaging - FLAIR-EPI. Observamos a superioridade da sequência FLAIR na detecção do aumento da intensidade de sinal da região hipocampal, particularmente com cortes coronais, em relação às sequências SE e FSE, com a vantagem de ser uma técnica de rápida execução. A sequência STIR evidenciou adelgaçamento da cortical do hipocampo, na metade dos casos que apresentavam alteração de sinal.The purpose of this study is to evaluate morpholologycal and signal intensity changes in the hippocampus in patients with medically intractable temporal lobe epilepsy. We studied 8 patients with mesial temporal sclerosis using a 1.5 -T MR and the following sequences Spin Eco- SE, Fast Spin Echo- FSE, Fluid Atenuation Inversion Recovery Echo Planar Imaging - FLAIR-EPI. We noticed a sensitive increase signal intensity on FLAIR- EPI sequences, particularly, in coronal images, than on SE and FSE sequences. The STIR sequence showed a cortical hippocampus atrophy in half of the cases, in whom signal abnormalities were present.

  4. Comparison of Diffusion-Weighted Imaging in the Human Brain Using Readout-Segmented EPI and PROPELLER Turbo Spin Echo With Single-Shot EPI at 7 T MRI.

    Science.gov (United States)

    Kida, Ikuhiro; Ueguchi, Takashi; Matsuoka, Yuichiro; Zhou, Kun; Stemmer, Alto; Porter, David

    2016-07-01

    The purpose of the present study was to compare periodically rotated overlapping parallel lines with enhanced reconstruction-type turbo spin echo diffusion-weighted imaging (pTSE-DWI) and readout-segmented echo planar imaging (rsEPI-DWI) with single-shot echo planar imaging (ssEPI-DWI) in a 7 T human MR system. We evaluated the signal-to-noise ratio (SNR), image distortion, and apparent diffusion coefficient values in the human brain. Six healthy volunteers were included in this study. The study protocol was approved by our institutional review board. All measurements were performed at 7 T using pTSE-DWI, rsEPI-DWI, and ssEPI-DWI sequences. The spatial resolution was 1.2 × 1.2 mm in-plane with a 3-mm slice thickness. Signal-to-noise ratio was measured using 2 scans. The ssEPI-DWI sequence showed significant image blurring, whereas pTSE-DWI and rsEPI-DWI sequences demonstrated high image quality with low geometrical distortion compared with reference T2-weighted, turbo spin echo images. Signal loss in ventral regions near the air-filled paranasal sinus/nasal cavity was found in ssEPI-DWI and rsEPI-DWI but not pTSE-DWI. The apparent diffusion coefficient values for ssEPI-DWI were 824 ± 17 × 10 and 749 ± 25 × 10 mm/s in the gray matter and white matter, respectively; the values obtained for pTSE-DWI were 798 ± 21 × 10 and 865 ± 40 × 10 mm/s; and the values obtained for rsEPI-DWI were 730 ± 12 × 10 and 722 ± 25 × 10 mm/s. The pTSE-DWI images showed no additional distortion comparison to the T2-weighted images, but had a lower SNR than ssEPI-DWI and rsEPI-DWI. The rsEPI-DWI sequence provided high-quality images with minor distortion and a similar SNR to ssEPI-DWI. Our results suggest that the benefits of the rsEPI-DWI and pTSE-DWI sequences, in terms of SNR, image quality, and image distortion, appear to outweigh those of ssEPI-DWI. Thus, pTSE-DWI and rsEPI-DWI at 7 T have great potential use for clinical diagnoses. However, it is noteworthy that both

  5. Efficient Computation of Info-Gap Robustness for Finite Element Models

    International Nuclear Information System (INIS)

    Stull, Christopher J.; Hemez, Francois M.; Williams, Brian J.

    2012-01-01

    A recent research effort at LANL proposed info-gap decision theory as a framework by which to measure the predictive maturity of numerical models. Info-gap theory explores the trade-offs between accuracy, that is, the extent to which predictions reproduce the physical measurements, and robustness, that is, the extent to which predictions are insensitive to modeling assumptions. Both accuracy and robustness are necessary to demonstrate predictive maturity. However, conducting an info-gap analysis can present a formidable challenge, from the standpoint of the required computational resources. This is because a robustness function requires the resolution of multiple optimization problems. This report offers an alternative, adjoint methodology to assess the info-gap robustness of Ax = b-like numerical models solved for a solution x. Two situations that can arise in structural analysis and design are briefly described and contextualized within the info-gap decision theory framework. The treatments of the info-gap problems, using the adjoint methodology are outlined in detail, and the latter problem is solved for four separate finite element models. As compared to statistical sampling, the proposed methodology offers highly accurate approximations of info-gap robustness functions for the finite element models considered in the report, at a small fraction of the computational cost. It is noted that this report considers only linear systems; a natural follow-on study would extend the methodologies described herein to include nonlinear systems.

  6. MDRD or CKD-EPI for glomerular filtration rate estimation in living kidney donors

    Directory of Open Access Journals (Sweden)

    Carla Burballa

    2018-03-01

    Full Text Available Introduction: The evaluation of the measured Glomerular Filtration Rate (mGFR or estimated Glomerular Filtration Rate (eGFR is key in the proper assessment of the renal function of potential kidney donors. We aim to study the correlation between glomerular filtration rate estimation equations and the measured methods for determining renal function. Material and methods: We analyzed the relationship between baseline GFR values measured by Tc-99m-DTPA (diethylene-triamine-pentaacetate and those estimated by the four-variable Modification of Diet in Renal Disease (MDRD4 and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI equations in a series of living donors at our institution. Results: We included 64 donors (70.6% females; mean age 48.3 ± 11 years. Baseline creatinine was 0.8 ± 0.1 mg/dl and it was 1.1 ± 0.2 mg/dl one year after donation. The equations underestimated GFR when measured by Tc99m-DTPA (MDRD4 – 9.4 ± 25 ml/min, P < .05, and CKD-EPI – 4.4 ± 21 ml/min. The correlation between estimation equations and the measured method was superior for CKD-EPI (r = .41; P < .004 than for MDRD4 (r = .27; P < .05. eGFR decreased to 59.6 ± 11 (MDRD4 and 66.2 ± 14 ml/min (CKD-EPI one year after donation. This means a mean eGFR reduction of 28.2 ± 16.7 ml/min (MDRD4 and 27.31 ± 14.4 ml/min (CKD-EPI at one year. Conclusions: In our experience, CKD-EPI is the equation that better correlates with mGFR-Tc99m-DTPA when assessing renal function for donor screening purposes. Resumen: Introducción: El estudio del filtrado glomerular medido (FGm o del estimado (FGe es el eje de la evaluación adecuada de la función renal en la valoración de un potencial donante vivo renal. Nos planteamos estudiar la correlación entre las fórmulas de estimación del FG y los métodos de medición para

  7. Software reengineering

    Science.gov (United States)

    Fridge, Ernest M., III

    1991-01-01

    Today's software systems generally use obsolete technology, are not integrated properly with other software systems, and are difficult and costly to maintain. The discipline of reverse engineering is becoming prominent as organizations try to move their systems up to more modern and maintainable technology in a cost effective manner. JSC created a significant set of tools to develop and maintain FORTRAN and C code during development of the Space Shuttle. This tool set forms the basis for an integrated environment to re-engineer existing code into modern software engineering structures which are then easier and less costly to maintain and which allow a fairly straightforward translation into other target languages. The environment will support these structures and practices even in areas where the language definition and compilers do not enforce good software engineering. The knowledge and data captured using the reverse engineering tools is passed to standard forward engineering tools to redesign or perform major upgrades to software systems in a much more cost effective manner than using older technologies. A beta vision of the environment was released in Mar. 1991. The commercial potential for such re-engineering tools is very great. CASE TRENDS magazine reported it to be the primary concern of over four hundred of the top MIS executives.

  8. Rapid whole-brain resting-state fMRI at 3 T: Efficiency-optimized three-dimensional EPI versus repetition time-matched simultaneous-multi-slice EPI.

    Science.gov (United States)

    Stirnberg, Rüdiger; Huijbers, Willem; Brenner, Daniel; Poser, Benedikt A; Breteler, Monique; Stöcker, Tony

    2017-12-01

    State-of-the-art simultaneous-multi-slice (SMS-)EPI and 3D-EPI share several properties that benefit functional MRI acquisition. Both sequences employ equivalent parallel imaging undersampling with controlled aliasing to achieve high temporal sampling rates. As a volumetric imaging sequence, 3D-EPI offers additional means of acceleration complementary to 2D-CAIPIRINHA sampling, such as fast water excitation and elliptical sampling. We performed an application-oriented comparison between a tailored, six-fold CAIPIRINHA-accelerated 3D-EPI protocol at 530 ms temporal and 2.4 mm isotropic spatial resolution and an SMS-EPI protocol with identical spatial and temporal resolution for whole-brain resting-state fMRI at 3 T. The latter required eight-fold slice acceleration to compensate for the lack of elliptical sampling and fast water excitation. Both sequences used vendor-supplied on-line image reconstruction. We acquired test/retest resting-state fMRI scans in ten volunteers, with simultaneous acquisition of cardiac and respiration data, subsequently used for optional physiological noise removal (nuisance regression). We found that the 3D-EPI protocol has significantly increased temporal signal-to-noise ratio throughout the brain as compared to the SMS-EPI protocol, especially when employing motion and nuisance regression. Both sequence types reliably identified known functional networks with stronger functional connectivity values for the 3D-EPI protocol. We conclude that the more time-efficient 3D-EPI primarily benefits from reduced parallel imaging noise due to a higher, actual k-space sampling density compared to SMS-EPI. The resultant BOLD sensitivity increase makes 3D-EPI a valuable alternative to SMS-EPI for whole-brain fMRI at 3 T, with voxel sizes well below 3 mm isotropic and sampling rates high enough to separate dominant cardiac signals from BOLD signals in the frequency domain. Copyright © 2017 Elsevier Inc. All rights reserved.

  9. Antitumor agent 25-epi Ritterostatin GN1N induces endoplasmic reticulum stress and autophagy mediated cell death in melanoma cells.

    Science.gov (United States)

    Riaz Ahmed, Kausar Begam; Kanduluru, Ananda Kumar; Feng, Li; Fuchs, Philip L; Huang, Peng

    2017-05-01

    Metastatic melanoma is the most aggressive of all skin cancers and is associated with poor prognosis owing to lack of effective treatments. 25-epi Ritterostatin GN1N is a novel antitumor agent with yet undefined mechanisms of action. We sought to delineate the antitumor mechanisms of 25-epi Ritterostatin GN1N in melanoma cells to determine the potential of this compound as a treatment for melanoma. Activation of the endoplasmic reticulum (ER) stress protein glucose-regulated protein 78 (GRP78) has been associated with increased melanoma progression, oncogenic signaling, drug resistance, and suppression of cell death. We found that 25-epi Ritterostatin GN1N induced cell death in melanoma cells at nanomolar concentrations, and this cell death was characterized by inhibition of GRP78 expression, increased expression of the ER stress marker CHOP, loss of mitochondrial membrane potential, and lipidation of the autophagy marker protein LC3B. Importantly, normal melanocytes exhibited limited sensitivity to 25-epi Ritterostatin GN1N. Subsequent in vivo results demonstrated that 25-epi Ritterostatin GN1N reduced melanoma growth in mouse tumor xenografts and did not affect body weight, suggesting minimal toxicity. In summary, our findings indicate that 25-epi Ritterostatin GN1N causes ER stress and massive autophagy, leading to collapse of mitochondrial membrane potential and cell death in melanoma cells, with minimal effects in normal melanocytes. Thus, 25-epi Ritterostatin GN1N is a promising anticancer agent that warrants further investigation.

  10. Software Authentication

    International Nuclear Information System (INIS)

    Wolford, J.K.; Geelhood, B.D.; Hamilton, V.A.; Ingraham, J.; MacArthur, D.W.; Mitchell, D.J.; Mullens, J.A.; Vanier, P. E.; White, G.K.; Whiteson, R.

    2001-01-01

    The effort to define guidance for authentication of software for arms control and nuclear material transparency measurements draws on a variety of disciplines and has involved synthesizing established criteria and practices with newer methods. Challenges include the need to protect classified information that the software manipulates as well as deal with the rapid pace of innovation in the technology of nuclear material monitoring. The resulting guidance will shape the design of future systems and inform the process of authentication of instruments now being developed. This paper explores the technical issues underlying the guidance and presents its major tenets

  11. Software engineering

    CERN Document Server

    Thorin, Marc

    1985-01-01

    Software Engineering describes the conceptual bases as well as the main methods and rules on computer programming. This book presents software engineering as a coherent and logically built synthesis and makes it possible to properly carry out an application of small or medium difficulty that can later be developed and adapted to more complex cases. This text is comprised of six chapters and begins by introducing the reader to the fundamental notions of entities, actions, and programming. The next two chapters elaborate on the concepts of information and consistency domains and show that a proc

  12. Microbial Detoxification of Deoxynivalenol (DON), Assessed via a Lemna minor L. Bioassay, through Biotransformation to 3-epi-DON and 3-epi-DOM-1.

    Science.gov (United States)

    Vanhoutte, Ilse; De Mets, Laura; De Boevre, Marthe; Uka, Valdet; Di Mavungu, José Diana; De Saeger, Sarah; De Gelder, Leen; Audenaert, Kris

    2017-02-13

    Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON) biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L. was developed. A dose-response analysis revealed significant inhibition in the growth of L. minor exposed to DON concentrations of 0.25 mg/L and higher. Concentrations above 1 mg/L were lethal for the plant. This bioassay is far more sensitive than previously described systems. The bioassay was implemented to screen microbial enrichment cultures, originating from rumen fluid, soil, digestate and activated sludge, on their biotransformation and detoxification capability of DON. The enrichment cultures originating from soil and activated sludge were capable of detoxifying and degrading 5 and 50 mg/L DON. In addition, the metabolites 3-epi-DON and the epimer of de-epoxy-DON (3-epi-DOM-1) were found as biotransformation products of both consortia. Our work provides a new valuable tool to screen microbial cultures for their detoxification capacity.

  13. Microbial Detoxification of Deoxynivalenol (DON, Assessed via a Lemna minor L. Bioassay, through Biotransformation to 3-epi-DON and 3-epi-DOM-1

    Directory of Open Access Journals (Sweden)

    Ilse Vanhoutte

    2017-02-01

    Full Text Available Mycotoxins are toxic metabolites produced by fungi. To mitigate mycotoxins in food or feed, biotransformation is an emerging technology in which microorganisms degrade toxins into non-toxic metabolites. To monitor deoxynivalenol (DON biotransformation, analytical tools such as ELISA and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS are typically used. However, these techniques do not give a decisive answer about the remaining toxicity of possible biotransformation products. Hence, a bioassay using Lemna minor L. was developed. A dose–response analysis revealed significant inhibition in the growth of L. minor exposed to DON concentrations of 0.25 mg/L and higher. Concentrations above 1 mg/L were lethal for the plant. This bioassay is far more sensitive than previously described systems. The bioassay was implemented to screen microbial enrichment cultures, originating from rumen fluid, soil, digestate and activated sludge, on their biotransformation and detoxification capability of DON. The enrichment cultures originating from soil and activated sludge were capable of detoxifying and degrading 5 and 50 mg/L DON. In addition, the metabolites 3-epi-DON and the epimer of de-epoxy-DON (3-epi-DOM-1 were found as biotransformation products of both consortia. Our work provides a new valuable tool to screen microbial cultures for their detoxification capacity.

  14. CON4EI: EpiOcular™ Eye Irritation Test (EpiOcular™ EIT) for hazard identification and labelling of eye irritating chemicals.

    Science.gov (United States)

    Kandarova, H; Letasiova, S; Adriaens, E; Guest, R; Willoughby, J A; Drzewiecka, A; Gruszka, K; Alépée, Nathalie; Verstraelen, Sandra; Van Rompay, An R

    2018-06-01

    Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI project was to develop tiered testing strategies for eye irritation assessment. A set of 80 reference chemicals (38 liquids and 42 solids) was tested with eight different methods. Here, the results obtained with the EpiOcular™ Eye Irritation Test (EIT), adopted as OECD TG 492, are shown. The primary aim of this study was to evaluate of the performance of the test method to discriminate between chemicals not requiring classification for serious eye damage/eye irritancy (No Category) and chemicals requiring classification and labelling. In addition, the predictive capacity in terms of in vivo drivers of classification (i.e. corneal opacity, conjunctival redness and persistence at day 21) was investigated. EpiOcular™ EIT achieved a sensitivity of 97%, a specificity of 87% and accuracy of 95% and also confirmed its excellent reproducibility (100%) from the original validation. The assay was applicable to all chemical categories tested in this project and its performance was not limited to the particular driver of the classification. In addition to the existing prediction model for dichotomous categorization, a new prediction model for Cat 1 is suggested. Copyright © 2017. Published by Elsevier Ltd.

  15. Modification of diet in renal disease (MDRD study and CKD epidemiology collaboration (CKD-EPI equations for Taiwanese adults.

    Directory of Open Access Journals (Sweden)

    Ling-I Chen

    Full Text Available Estimated glomerular filtration rate (eGFR using the Modification of Diet in Renal Disease (MDRD study or the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI equations may not be accurate for Asians; thus, we developed modified eGFR equations for Taiwanese adults.This cross-sectional study compared the Taiwanese eGFR equations, the MDRD study, and the CKD-EPI equations with inulin clearance (Cin. A total of 695 adults including 259 healthy volunteers and 436 CKD patients were recruited. Participants from the Kaohsiung Medical University Hospital were used as the development set (N = 556 to develop the Taiwanese eGFR equations, whereas participants from the National Taiwan University Hospital were used as the validation set (N = 139 for external validation.The Taiwanese eGFR equations were developed by using the extended Bland-Altman plot in the development set. The Taiwanese MDRD equation was 1.309 × MDRD0.912, Taiwanese CKD-EPI was 1.262×CKD-EPI0.914 and Taiwanese four-level CKD-EPI was 1.205 × four-level CKD-EPI0.914. In the validation set, the Taiwanese equations had the lowest bias, the Taiwanese equations and the Japanese CKD-EPI equation had the lowest RMSE, whereas the Taiwanese and the Japanese equations had the best precision and the highest P30 among all equations. However, the Taiwanese MDRD equation had higher concordance correlation than did the Taiwanese CKD-EPI, the Taiwanese four-level CKD-EPI and the Japanese equations. Moreover, only the Taiwanese equations had no proportional bias among all of the equations. Finally, the Taiwanese MDRD equation had the best diagnostic performance in terms of ordinal logistic regression among all of the equations.The Taiwanese MDRD equation is better than the MDRD, CKD-EPI, Japanese, Asian, Thai, Taiwanese CKD-EPI, and Taiwanese four-level CKD-EPI equations for Taiwanese adults.

  16. The relative roles of ANC and EPI in the continuous distribution of LLINs: a qualitative study in four countries.

    Science.gov (United States)

    Theiss-Nyland, Katherine; Koné, Diakalia; Karema, Corine; Ejersa, Waqo; Webster, Jayne; Lines, Jo

    2017-05-01

    The continuous distribution of long-lasting insecticidal nets (LLINs) for malaria prevention, through the antenatal care (ANC) and the Expanded Programme on Immunizations (EPI), is recommended by the WHO to improve and maintain LLIN coverage. Despite these recommendations, little is known about the relative strengths and weaknesses of the ANC and EPI-based LLIN distribution. This study aimed to explore and compare the roles of the ANC and EPI for LLIN distribution in four African countries. In a qualitative evaluation of continuous distribution through the ANC and EPI, semi-structured, individual and group interviews were conducted in Kenya, Malawi, Mali, and Rwanda. Respondents included national, sub-national, and facility-level health staff, and were selected to capture a range of roles related to malaria, ANC and EPI programmes. Policies, guidelines, and data collection tools were reviewed as a means of triangulation to assess the structure of LLIN distribution, and the methods of data collection and reporting for malaria, ANC and EPI programmes. In the four countries visited, distribution of LLINs was more effectively integrated through ANC than through EPI because of a) stronger linkages and involvement between malaria and reproductive health programmes, as compared to malaria and EPI, and b) more complete programme monitoring for ANC-based distribution, compared to EPI-based distribution. Opportunities for improving the distribution of LLINs through these channels exist, especially in the case of EPI. For both ANC and EPI, integrated distribution of LLINs has the potential to act as an incentive, improving the already strong coverage of both these essential services. The collection and reporting of data on LLINs distributed through the ANC and EPI can provide insight into the performance of LLIN distribution within these programmes. Greater attention to data collection and use, by both the global malaria community, and the integrated programmes, can improve

  17. Dual regression physiological modeling of resting-state EPI power spectra: Effects of healthy aging.

    Science.gov (United States)

    Viessmann, Olivia; Möller, Harald E; Jezzard, Peter

    2018-02-02

    Aging and disease-related changes in the arteriovasculature have been linked to elevated levels of cardiac cycle-induced pulsatility in the cerebral microcirculation. Functional magnetic resonance imaging (fMRI), acquired fast enough to unalias the cardiac frequency contributions, can be used to study these physiological signals in the brain. Here, we propose an iterative dual regression analysis in the frequency domain to model single voxel power spectra of echo planar imaging (EPI) data using external recordings of the cardiac and respiratory cycles as input. We further show that a data-driven variant, without external physiological traces, produces comparable results. We use this framework to map and quantify cardiac and respiratory contributions in healthy aging. We found a significant increase in the spatial extent of cardiac modulated white matter voxels with age, whereas the overall strength of cardiac-related EPI power did not show an age effect. Copyright © 2018. Published by Elsevier Inc.

  18. Reviews, Software.

    Science.gov (United States)

    Science Teacher, 1988

    1988-01-01

    Reviews two computer software packages for use in physical science, physics, and chemistry classes. Includes "Physics of Model Rocketry" for Apple II, and "Black Box" for Apple II and IBM compatible computers. "Black Box" is designed to help students understand the concept of indirect evidence. (CW)

  19. Software Reviews.

    Science.gov (United States)

    Kinnaman, Daniel E.; And Others

    1988-01-01

    Reviews four educational software packages for Apple, IBM, and Tandy computers. Includes "How the West was One + Three x Four,""Mavis Beacon Teaches Typing,""Math and Me," and "Write On." Reviews list hardware requirements, emphasis, levels, publisher, purchase agreements, and price. Discusses the strengths…

  20. Software Review.

    Science.gov (United States)

    McGrath, Diane, Ed.

    1989-01-01

    Reviewed is a computer software package entitled "Audubon Wildlife Adventures: Grizzly Bears" for Apple II and IBM microcomputers. Included are availability, hardware requirements, cost, and a description of the program. The murder-mystery flavor of the program is stressed in this program that focuses on illegal hunting and game…

  1. Software Reviews.

    Science.gov (United States)

    Teles, Elizabeth, Ed.; And Others

    1990-01-01

    Reviewed are two computer software packages for Macintosh microcomputers including "Phase Portraits," an exploratory graphics tool for studying first-order planar systems; and "MacMath," a set of programs for exploring differential equations, linear algebra, and other mathematical topics. Features, ease of use, cost, availability, and hardware…

  2. MIAWARE Software

    DEFF Research Database (Denmark)

    Wilkowski, Bartlomiej; Pereira, Oscar N. M.; Dias, Paulo

    2008-01-01

    is automatically generated. Furthermore, MIAWARE software is accompanied with an intelligent search engine for medical reports, based on the relations between parts of the lungs. A logical structure of the lungs is introduced to the search algorithm through the specially developed ontology. As a result...

  3. IMGT/GeneInfo: enhancing V(D)J recombination database accessibility

    Science.gov (United States)

    Baum, Thierry-Pascal; Pasqual, Nicolas; Thuderoz, Florence; Hierle, Vivien; Chaume, Denys; Lefranc, Marie-Paule; Jouvin-Marche, Evelyne; Marche, Patrice-Noël; Demongeot, Jacques

    2004-01-01

    IMGT/GeneInfo is a user-friendly online information system that provides information on data resulting from the complex mechanisms of immunoglobulin (IG) and T cell receptor (TR) V(D)J recombinations. For the first time, it is possible to visualize all the rearrangement parameters on a single page. IMGT/GeneInfo is part of the international ImMunoGeneTics information system® (IMGT), a high-quality integrated knowledge resource specializing in IG, TR, major histocompatibility complex (MHC), and related proteins of the immune system of human and other vertebrate species. The IMGT/GeneInfo system was developed by the TIMC and ICH laboratories (with the collaboration of LIGM), and is the first example of an external system being incorporated into IMGT. In this paper, we report the first part of this work. IMGT/GeneInfo_TR deals with the human and mouse TRA/TRD and TRB loci of the TR. Data handling and visualization are complementary to the current data and tools in IMGT, and will subsequently allow the modelling of V(D)J gene use, and thus, to predict non-standard recombination profiles which may eventually be found in conditions such as leukaemias or lymphomas. Access to IMGT/GeneInfo is free and can be found at http://imgt.cines.fr/GeneInfo. PMID:14681357

  4. Clinically feasible NODDI characterization of glioma using multiband EPI at 7 T

    Directory of Open Access Journals (Sweden)

    Qiuting Wen

    2015-01-01

    Full Text Available Recent technological progress in the multiband echo planer imaging (MB EPI technique enables accelerated MR diffusion weighted imaging (DWI and allows whole brain, multi-b-value diffusion imaging to be acquired within a clinically feasible time. However, its applications at 7 T have been limited due to B1 field inhomogeneity and increased susceptibility artifact. It is an ongoing debate whether DWI at 7 T can be performed properly in patients, and a systematic SNR comparison for multiband spin-echo EPI between 3 T and 7 T has not been methodically studied. The goal of this study was to use MB EPI at 7 T in order to obtain 90-directional multi-shell DWI within a clinically feasible acquisition time for patients with glioma. This study included an SNR comparison between 3 T and 7 T, and the application of B1 mapping and distortion correction procedures for reducing the impact of variations in B0 and B1. The optimized multiband sequence was applied in 20 patients with glioma to generate both DTI and NODDI maps for comparison of values in tumor and normal appearing white matter (NAWM. Our SNR analysis showed that MB EPI at 7 T was comparable to that at 3 T, and the data quality acquired in patients was clinically acceptable. NODDI maps provided unique contrast within the T2 lesion that was not seen in anatomical images or DTI maps. Such contrast may reflect the complexity of tissue compositions associated with disease progression and treatment effects. The ability to consistently obtain high quality diffusion data at 7 T will contribute towards the implementation of a comprehensive brain MRI examination at ultra-high field.

  5. epiDMS: Data Management and Analytics for Decision-Making From Epidemic Spread Simulation Ensembles.

    Science.gov (United States)

    Liu, Sicong; Poccia, Silvestro; Candan, K Selçuk; Chowell, Gerardo; Sapino, Maria Luisa

    2016-12-01

    Carefully calibrated large-scale computational models of epidemic spread represent a powerful tool to support the decision-making process during epidemic emergencies. Epidemic models are being increasingly used for generating forecasts of the spatial-temporal progression of epidemics at different spatial scales and for assessing the likely impact of different intervention strategies. However, the management and analysis of simulation ensembles stemming from large-scale computational models pose challenges, particularly when dealing with multiple interdependent parameters, spanning multiple layers and geospatial frames, affected by complex dynamic processes operating at different resolutions. We describe and illustrate with examples a novel epidemic simulation data management system, epiDMS, that was developed to address the challenges that arise from the need to generate, search, visualize, and analyze, in a scalable manner, large volumes of epidemic simulation ensembles and observations during the progression of an epidemic. epiDMS is a publicly available system that facilitates management and analysis of large epidemic simulation ensembles. epiDMS aims to fill an important hole in decision-making during healthcare emergencies by enabling critical services with significant economic and health impact. © The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.

  6. DESIGN OF LOW EPI AND HIGH THROUGHPUT CORDIC CELL TO IMPROVE THE PERFORMANCE OF MOBILE ROBOT

    Directory of Open Access Journals (Sweden)

    P. VELRAJKUMAR

    2014-04-01

    Full Text Available This paper mainly focuses on pass logic based design, which gives an low Energy Per Instruction (EPI and high throughput COrdinate Rotation Digital Computer (CORDIC cell for application of robotic exploration. The basic components of CORDIC cell namely register, multiplexer and proposed adder is designed using pass transistor logic (PTL design. The proposed adder is implemented in bit-parallel iterative CORDIC circuit whereas designed using DSCH2 VLSI CAD tool and their layouts are generated by Microwind 3 VLSI CAD tool. The propagation delay, area and power dissipation are calculated from the simulated results for proposed adder based CORDIC cell. The EPI, throughput and effect of temperature are calculated from generated layout. The output parameter of generated layout is analysed using BSIM4 advanced analyzer. The simulated result of the proposed adder based CORDIC circuit is compared with other adder based CORDIC circuits. From the analysis of these simulated results, it was found that the proposed adder based CORDIC circuit dissipates low power, gives faster response, low EPI and high throughput.

  7. Managing Uncertainty in Water Infrastructure Design Using Info-gap Robustness

    Science.gov (United States)

    Irias, X.; Cicala, D.

    2013-12-01

    Info-gap theory, a tool for managing deep uncertainty, can be of tremendous value for design of water systems in areas of high seismic risk. Maintaining reliable water service in those areas is subject to significant uncertainties including uncertainty of seismic loading, unknown seismic performance of infrastructure, uncertain costs of innovative seismic-resistant construction, unknown costs to repair seismic damage, unknown societal impacts from downtime, and more. Practically every major earthquake that strikes a population center reveals additional knowledge gaps. In situations of such deep uncertainty, info-gap can offer advantages over traditional approaches, whether deterministic approaches that use empirical safety factors to address the uncertainties involved, or probabilistic methods that attempt to characterize various stochastic properties and target a compromise between cost and reliability. The reason is that in situations of deep uncertainty, it may not be clear what safety factor would be reasonable, or even if any safety factor is sufficient to address the uncertainties, and we may lack data to characterize the situation probabilistically. Info-gap is a tool that recognizes up front that our best projection of the future may be wrong. Thus, rather than seeking a solution that is optimal for that projection, info-gap seeks a solution that works reasonably well for all plausible conditions. In other words, info-gap seeks solutions that are robust in the face of uncertainty. Info-gap has been used successfully across a wide range of disciplines including climate change science, project management, and structural design. EBMUD is currently using info-gap to help it gain insight into possible solutions for providing reliable water service to an island community within its service area. The island, containing about 75,000 customers, is particularly vulnerable to water supply disruption from earthquakes, since it has negligible water storage and is

  8. Inhibitory effects of methyl-3,5-di-O-caffeoyl-epi-quinate on RANKL-induced osteoclast differentiation.

    Science.gov (United States)

    Kim, Tae Hoon; Ihn, Hye Jung; Kim, Kiryeong; Cho, Hye-Sung; Shin, Hong-In; Bae, Yong Chul; Park, Eui Kyun

    2018-04-09

    In this study, we have shown that methyl-3,5-di-O-caffeoyl-epi-quinate, a naturally occurring compound isolated from Ainsliaea acerifolia, inhibits receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinucleated tartrate-resistant acid phosphatase (TRAP)-positive osteoclasts and the expression of osteoclast marker genes. Methyl-3,5-di-O-caffeoyl-epi-quinate also inhibited RANKL-induced activation of p38, Akt and extracellular signal-regulated kinase (ERK) as well as the expression of nuclear factor of activated T-cell (NFATc1), the key regulator of osteoclast differentiation. Negative regulators for osteoclast differentiation was upregulated by methyl-3,5-di-O-caffeoyl-epi-quinate. Collectively, our results suggested that methyl-3,5-di-O-caffeoyl-epi-quinate suppresses osteoclast differentiation via downregulation of RANK signaling pathways and NFATc1. Copyright © 2018 Elsevier Ltd. All rights reserved.

  9. Software Tools for Software Maintenance

    Science.gov (United States)

    1988-10-01

    COMMUNICATIONS, AND COMPUTER SCIENCES I ,(AIRMICS) FO~SOFTWARE TOOLS (.o FOR SOF1 ’ARE MAINTENANCE (ASQBG-1-89-001) October, 1988 DTIC ELECTE -ifB...SUNWW~. B..c Program An~Iysw HA.c C-Tractr C Cobol Stncturing Facility VS Cobol 11 F-Scan Foctma Futbol Cobol Fortran Sltiuc Code Anaiyaer Fortran IS

  10. EPIQR software

    Energy Technology Data Exchange (ETDEWEB)

    Flourentzos, F. [Federal Institute of Technology, Lausanne (Switzerland); Droutsa, K. [National Observatory of Athens, Athens (Greece); Wittchen, K.B. [Danish Building Research Institute, Hoersholm (Denmark)

    1999-11-01

    The support of the EPIQR method is a multimedia computer program. Several modules help the users of the method to treat the data collected during a diagnosis survey, to set up refurbishment scenario and calculate their cost or energy performance, and finally to visualize the results in a comprehensive way and to prepare quality reports. This article presents the structure and the main features of the software. (au)

  11. Software preservation

    Directory of Open Access Journals (Sweden)

    Tadej Vodopivec

    2011-01-01

    Full Text Available Comtrade Ltd. covers a wide range of activities related to information and communication technologies; its deliverables include web applications, locally installed programs,system software, drivers, embedded software (used e.g. in medical devices, auto parts,communication switchboards. Also the extensive knowledge and practical experience about digital long-term preservation technologies have been acquired. This wide spectrum of activities puts us in the position to discuss the often overlooked aspect of the digital preservation - preservation of software programs. There are many resources dedicated to digital preservation of digital data, documents and multimedia records,but not so many about how to preserve the functionalities and features of computer programs. Exactly these functionalities - dynamic response to inputs - render the computer programs rich compared to documents or linear multimedia. The article opens the questions on the beginning of the way to the permanent digital preservation. The purpose is to find a way in the right direction, where all relevant aspects will be covered in proper balance. The following questions are asked: why at all to preserve computer programs permanently, who should do this and for whom, when we should think about permanent program preservation, what should be persevered (such as source code, screenshots, documentation, and social context of the program - e.g. media response to it ..., where and how? To illustrate the theoretic concepts given the idea of virtual national museum of electronic banking is also presented.

  12. MeInfoText 2.0: gene methylation and cancer relation extraction from biomedical literature

    Directory of Open Access Journals (Sweden)

    Fang Yu-Ching

    2011-12-01

    Full Text Available Abstract Background DNA methylation is regarded as a potential biomarker in the diagnosis and treatment of cancer. The relations between aberrant gene methylation and cancer development have been identified by a number of recent scientific studies. In a previous work, we used co-occurrences to mine those associations and compiled the MeInfoText 1.0 database. To reduce the amount of manual curation and improve the accuracy of relation extraction, we have now developed MeInfoText 2.0, which uses a machine learning-based approach to extract gene methylation-cancer relations. Description Two maximum entropy models are trained to predict if aberrant gene methylation is related to any type of cancer mentioned in the literature. After evaluation based on 10-fold cross-validation, the average precision/recall rates of the two models are 94.7/90.1 and 91.8/90% respectively. MeInfoText 2.0 provides the gene methylation profiles of different types of human cancer. The extracted relations with maximum probability, evidence sentences, and specific gene information are also retrievable. The database is available at http://bws.iis.sinica.edu.tw:8081/MeInfoText2/. Conclusion The previous version, MeInfoText, was developed by using association rules, whereas MeInfoText 2.0 is based on a new framework that combines machine learning, dictionary lookup and pattern matching for epigenetics information extraction. The results of experiments show that MeInfoText 2.0 outperforms existing tools in many respects. To the best of our knowledge, this is the first study that uses a hybrid approach to extract gene methylation-cancer relations. It is also the first attempt to develop a gene methylation and cancer relation corpus.

  13. Enhancing Public Access to Relevant and Valued Medical Information: Fresh Directions for RadiologyInfo.org.

    Science.gov (United States)

    Rubin, Geoffrey D; Krishnaraj, Arun; Mahesh, Mahadevappa; Rajendran, Ramji R; Fishman, Elliot K

    2017-05-01

    RadiologyInfo.org is a public information portal designed to support patient care and broaden public awareness of the essential role radiology plays in overall patient health care. Over the past 14 years, RadiologyInfo.org has evolved considerably to provide access to more than 220 mixed-media descriptions of tests, treatments, and diseases through a spectrum of mobile and desktop platforms, social media, and downloadable documents in both English and Spanish. In 2014, the RSNA-ACR Public Information Website Committee, which stewards RadiologyInfo.org, developed 3- to 5-year strategic and implementation plans for the website. The process was informed by RadiologyInfo.org user surveys, formal stakeholder interviews, focus groups, and usability testing. Metrics were established as key performance indicators to assess progress toward the stated goals of (1) optimizing content to enhance patient-centeredness, (2) enhancing reach and engagement, and (3) maintaining sustainability. Major changes resulting from this process include a complete redesign of the website, the replacement of text-rich PowerPoint presentations with conversational videos, and the development of an affiliate network. Over the past year, visits to RadiologyInfo.org have increased by 60.27% to 1,424,523 in August 2016 from 235 countries and territories. Twenty-two organizations have affiliated with RadiologyInfo.org with new organizations being added on a monthly basis. RadiologyInfo provides a tangible demonstration of how radiologists can engage directly with the global public to educate them on the value of radiology in their health care and to allay concerns and dispel misconceptions. Regular self-assessment and responsive planning will ensure its continued growth and relevance. Copyright © 2016 American College of Radiology. Published by Elsevier Inc. All rights reserved.

  14. Echo-planar magnetic resonance imaging (EPI) with high-resolution matrix in intra-axial brain tumors

    Energy Technology Data Exchange (ETDEWEB)

    Bruening, R.; Scheidler, J.; Porn, U.; Reiser, M. [Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Seelos, K.; Yousry, T. [Department of Neuroradiology, Institute of Diagnostic Radiology, Klinikum Grosshadern, University of Munich (Germany); Exner, H. [Institute for Medical Epidemiology, Klinikum Grosshadern, University of Munich, Munich (Germany); Rosen, B.R. [Department of Radiology, Massachusetts General Hospital, NMR Center, Charlestown, MA (United States)

    1999-09-01

    The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investigated on a 1.5-T scanner. The conventional scan (SE, TR/TE = 2200/80 ms, 18 slices) was acquired in 8 min, 4 s, and EPI (TR/TE = 3000/80 ms, 18 slices) was completed in 25 s. The films were compared in a blinded trail by three radiologists. On the general impression and anatomic display, both sequences were rated to be of similar quality. Artifacts were slightly more pronounced at the skull base and around surgical clips using EPI. Tumor delineation was nearly equivalent using EPI, compared with the T2-weighted sequence. Echo-planar imaging reached diagnostic quality in all patients. Interleaved high-resolution EPI yielded sufficient quality to depict intra-axial, supratentorial brain tumors. Since EPI can be obtained in a small fraction of the time needed for conventional spin echo, in addition to other indications it could be considered to study patients unable to cooperate. (orig.) With 3 figs., 3 tabs., 27 refs.

  15. Echo-planar magnetic resonance imaging (EPI) with high-resolution matrix in intra-axial brain tumors

    International Nuclear Information System (INIS)

    Bruening, R.; Scheidler, J.; Porn, U.; Reiser, M.; Seelos, K.; Yousry, T.; Exner, H.; Rosen, B.R.

    1999-01-01

    The aim of this study was to assess the potential of high-speed interleaved echo-planar imaging (EPI) to achieve diagnostic image quality comparable to T2-weighted imaging in patients with brain tumors. Seventeen patients with intra-axial, supratentorial tumors (10 untreated gliomas, 7 radiated gliomas) were investigated on a 1.5-T scanner. The conventional scan (SE, TR/TE = 2200/80 ms, 18 slices) was acquired in 8 min, 4 s, and EPI (TR/TE = 3000/80 ms, 18 slices) was completed in 25 s. The films were compared in a blinded trail by three radiologists. On the general impression and anatomic display, both sequences were rated to be of similar quality. Artifacts were slightly more pronounced at the skull base and around surgical clips using EPI. Tumor delineation was nearly equivalent using EPI, compared with the T2-weighted sequence. Echo-planar imaging reached diagnostic quality in all patients. Interleaved high-resolution EPI yielded sufficient quality to depict intra-axial, supratentorial brain tumors. Since EPI can be obtained in a small fraction of the time needed for conventional spin echo, in addition to other indications it could be considered to study patients unable to cooperate. (orig.)

  16. Mothers' knowledge about EPI and its relation with age-appropriate vaccination of infants in peri-urban Karachi.

    Science.gov (United States)

    Siddiqi, Nazish; Siddiqi, Azfar-e-alam; Nisar, Nighat; Khan, Altaf

    2010-11-01

    To evaluate the relation between the knowledge of mothers about EPI vaccinations and their infant's coverage. Effect of other socio-demographic variables on mothers' knowledge and child's coverage was also assessed. A cross-sectional survey was conducted, utilizing World Health Organization's thirty-cluster sampling strategy. All households with at least one infant were considered eligible. After obtaining verbal consent, the mother was interviewed to assess her knowledge and attitudes towards EPI vaccination. Infant's coverage status was verified by checking EPI card or verbal inquiry. A knowledge score was developed by summing all correct answers. A total of 210 mothers (7 per cluster) were identified and interviewed. The number and proportion of mothers correctly identifying the seven EPI diseases were as follows; Tuberculosis 57 (27.1%), Diphtheria 53 (25.2%), Pertussis 71 (33.8%), Tetanus 70 (33.3%), Measles 85 (40.5%), Polio 91 (43.3%) and Hepatitis B 65 (31.0%). Only ninety four (44.8%) children were appropriately vaccinated for their age. In the multivariate model, mothers' knowledge was not significantly associated with appropriate vaccination of their children (p = 0.22), however, mothers' education was found to be significant (p Mothers' knowledge about EPI vaccination in peri-urban Karachi was quite low and not associated with their children's EPI coverage. Mothers' educational status, however, was significantly associated with Child's coverage. This finding depicts a better health seeking behaviour of a more educated mother.

  17. Establishing software quality assurance

    International Nuclear Information System (INIS)

    Malsbury, J.

    1983-01-01

    This paper is concerned with four questions about establishing software QA: What is software QA. Why have software QA. What is the role of software QA. What is necessary to ensure the success of software QA

  18. eGFRs from Asian-modified CKD-EPI and Chinese-modified CKD-EPI equations were associated better with hypertensive target organ damage in the community-dwelling elderly Chinese: the Northern Shanghai Study

    Directory of Open Access Journals (Sweden)

    Ji H

    2017-08-01

    Full Text Available Hongwei Ji,1,* Han Zhang,1,* Jing Xiong,1 Shikai Yu,1 Chen Chi,1 Bin Bai,1 Jue Li,2 Jacques Blacher,3 Yi Zhang,1,* Yawei Xu1,* 1Department of Cardiology, Shanghai Tenth People’s Hospital, 2Department of Prevention, Tongji University School of Medicine, Shanghai, People’s Republic of China; 3Paris Descartes University, AP-HP, Diagnosis and Therapeutic Center, Hôtel-Dieu, Paris, France *These authors contributed equally to this work Background: With increasing age, estimated glomerular filtration rate (eGFR decline is a frequent manifestation and is strongly associated with other preclinical target organ damage (TOD. In literature, many equations exist in assessing patients’ eGFR. However, these equations were mainly derived and validated in the population from Western countries, which equation should be used for risk stratification in the Chinese population remains unclear, as well as their comparison. Considering that TOD is a good marker for risk stratification in the elderly, in this analysis, we aimed to investigate whether the recent eGFR equations derived from Asian and Chinese are better associated with preclinical TOD than the other equations in elderly Chinese.Methods: A total of 1,599 community-dwelling elderly participants (age >65 years in northern Shanghai were prospectively recruited from June 2014 to August 2015. Conventional cardiovascular risk factors were assessed, and hypertensive TOD including left ventricular mass index (LVMI, carotid–femoral pulse wave velocity (cf-PWV, carotid intima-media thickness (IMT, ankle–brachial index (ABI and urine albumin to creatinine ratio (UACR was evaluated for each participant. Participant’s eGFR was calculated from the Modification of Diet in Renal Disease (MDRD, Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI, Chinese-abbreviated MDRD (c-aMDRD, Asian-modified CKD-EPI (aCKD-EPI equation and Chinese-modified CKD-EPI (cCKD-EPI equation.Results: In multivariate

  19. Software Prototyping

    Science.gov (United States)

    Del Fiol, Guilherme; Hanseler, Haley; Crouch, Barbara Insley; Cummins, Mollie R.

    2016-01-01

    Summary Background Health information exchange (HIE) between Poison Control Centers (PCCs) and Emergency Departments (EDs) could improve care of poisoned patients. However, PCC information systems are not designed to facilitate HIE with EDs; therefore, we are developing specialized software to support HIE within the normal workflow of the PCC using user-centered design and rapid prototyping. Objective To describe the design of an HIE dashboard and the refinement of user requirements through rapid prototyping. Methods Using previously elicited user requirements, we designed low-fidelity sketches of designs on paper with iterative refinement. Next, we designed an interactive high-fidelity prototype and conducted scenario-based usability tests with end users. Users were asked to think aloud while accomplishing tasks related to a case vignette. After testing, the users provided feedback and evaluated the prototype using the System Usability Scale (SUS). Results Survey results from three users provided useful feedback that was then incorporated into the design. After achieving a stable design, we used the prototype itself as the specification for development of the actual software. Benefits of prototyping included having 1) subject-matter experts heavily involved with the design; 2) flexibility to make rapid changes, 3) the ability to minimize software development efforts early in the design stage; 4) rapid finalization of requirements; 5) early visualization of designs; 6) and a powerful vehicle for communication of the design to the programmers. Challenges included 1) time and effort to develop the prototypes and case scenarios; 2) no simulation of system performance; 3) not having all proposed functionality available in the final product; and 4) missing needed data elements in the PCC information system. PMID:27081404

  20. InfoRoute: the CISMeF Context-specific Search Algorithm.

    Science.gov (United States)

    Merabti, Tayeb; Lelong, Romain; Darmoni, Stefan

    2015-01-01

    The aim of this paper was to present a practical InfoRoute algorithm and applications developed by CISMeF to perform a contextual information retrieval across multiple medical websites in different health domains. The algorithm was developed to treat multiple types of queries: natural, Boolean and advanced. The algorithm also generates multiple types of queries: Boolean query, PubMed query or Advanced query. Each query can be extended via an inter alignments relationship from UMLS and HeTOP portal. A web service and two web applications have been developed based on the InfoRoute algorithm to generate links-query across multiple websites, i.e.: "PubMed" or "ClinicalTrials.org". The InfoRoute algorithm is a useful tool to perform contextual information retrieval across multiple medical websites in both English and French.

  1. Info Nymphos

    Directory of Open Access Journals (Sweden)

    Erika Biddle

    2013-11-01

    Full Text Available This article investigates new forms of social control and the transformation of subjectivities made manifest in technological advances in networked media and human-computer interaction (HCI. A selection of contemporary social media platforms, including Twitter, Facebook, and online porn, are used to examine how modes of performativity and participation on the Internet are put to work as evolving forms of networked control. In particular, the paper examines how haptic forms of connecting with others online co-evolve with the Internet’s capacity to control at a distance.

  2. Supporting Info

    Data.gov (United States)

    U.S. Environmental Protection Agency — Supporting Information. This dataset is associated with the following publication: Washington , J., T. Jenkins, and E. Weber. Identification of Unsaturated and 2H...

  3. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    Directory of Open Access Journals (Sweden)

    Karen Amaral Tavares Pinheiro

    2011-09-01

    Full Text Available OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI across three time points: between 28 and 34 weeks of pregnancy (T1, 30 to 60 days postpartum (T2, and 12 months after childbirth (T3. RESULTS: The prevalence of depressive episodes was 5.0% at T1, 4.5% at T2, and 4.3% at T3. Mixed episodes were present in 3%, 1.7%, and 0.9% of subjects, respectively, and accounted for 61.1% of the cases of depression in the antenatal period, 37.5% in postpartum, and 21.4% at 12 months. Depressive and manic/hypomanic episodes were significantly associated during pregnancy and in postpartum, but not at 12 months after childbirth. CONCLUSION: Bipolar episodes were common in men with depressive symptoms during their partner's pregnancy in the postpartum period and, to a lesser extent, 12 months after childbirth. Therefore, this population should be carefully investigated for manic and hypomanic symptoms.OBJETIVO: Verificar a prevalência dos episódios depressivos e bipolares em homens no período pré e pós-natal, assim como 12 meses após o parto. MÉTODO: Estudo longitudinal com amostra de pais cujas crianças nasceram entre abril de 2007 e maio de 2008 em maternidades da cidade de Pelotas-RS, no sul do Brasil. Episódios depressivos e maníacos/hipomaníacos foram mensurados com o Mini Neuropsychiatric Interview em três tempos diferentes: entre a 28ª e 34ª semanas de gestação (T1, 30 a 60 dias após o parto (T2 e 12 meses após o nascimento da criança. RESULTADOS: A prevalência de episódios depressivos foi 5,0% em T1, 4,5% em T2 e 4,3% em T3

  4. InfoDROUGHT: Technical reliability assessment using crop yield data at the Spanish-national level

    Science.gov (United States)

    Contreras, Sergio; Garcia-León, David; Hunink, Johannes E.

    2017-04-01

    Drought monitoring (DM) is a key component of risk-centered drought preparedness plans and drought policies. InfoDROUGHT (www.infosequia.es) is a a site- and user-tailored and fully-integrated DM system which combines functionalities for: a) the operational satellite-based weekly-1km tracking of severity and spatial extent of drought impacts, b) the interactive and faster query and delivery of drought information through a web-mapping service. InfoDROUGHT has a flexible and modular structure. The calibration (threshold definitions) and validation of the system is performed by combining expert knowledge and auxiliary impact assessments and datasets. Different technical solutions (basic or advanced versions) or deployment options (open-standard or restricted-authenticated) can be purchased by end-users and customers according to their needs. In this analysis, the technical reliability of InfoDROUGHT and its performance for detecting drought impacts on agriculture has been evaluated in the 2003-2014 period by exploring and quantifying the relationships among the drought severity indices reported by InfoDROUGHT and the annual yield anomalies observed for different rainfed crops (maize, wheat, barley) at Spain. We hypothesize a positive relationship between the crop anomalies and the drought severity level detected by InfoDROUGHT. Annual yield anomalies were computed at the province administrative level as the difference between the annual yield reported by the Spanish Annual Survey of Crop Acreages and Yields (ESYRCE database) and the mean annual yield estimated during the study period. Yield anomalies were finally compared against drought greenness-based and thermal-based drought indices (VCI and TCI, respectively) to check the coherence of the outputs and the hypothesis stated. InfoDROUGHT has been partly funded by the Spanish Ministry of Economy and Competiveness through a Torres-Quevedo grant, and by the H2020-EU project "Bridging the Gap for Innovations in

  5. Global Software Engineering: A Software Process Approach

    Science.gov (United States)

    Richardson, Ita; Casey, Valentine; Burton, John; McCaffery, Fergal

    Our research has shown that many companies are struggling with the successful implementation of global software engineering, due to temporal, cultural and geographical distance, which causes a range of factors to come into play. For example, cultural, project managementproject management and communication difficulties continually cause problems for software engineers and project managers. While the implementation of efficient software processes can be used to improve the quality of the software product, published software process models do not cater explicitly for the recent growth in global software engineering. Our thesis is that global software engineering factors should be included in software process models to ensure their continued usefulness in global organisations. Based on extensive global software engineering research, we have developed a software process, Global Teaming, which includes specific practices and sub-practices. The purpose is to ensure that requirements for successful global software engineering are stipulated so that organisations can ensure successful implementation of global software engineering.

  6. Interleaved EPI diffusion imaging using SPIRiT-based reconstruction with virtual coil compression.

    Science.gov (United States)

    Dong, Zijing; Wang, Fuyixue; Ma, Xiaodong; Zhang, Zhe; Dai, Erpeng; Yuan, Chun; Guo, Hua

    2018-03-01

    To develop a novel diffusion imaging reconstruction framework based on iterative self-consistent parallel imaging reconstruction (SPIRiT) for multishot interleaved echo planar imaging (iEPI), with computation acceleration by virtual coil compression. As a general approach for autocalibrating parallel imaging, SPIRiT improves the performance of traditional generalized autocalibrating partially parallel acquisitions (GRAPPA) methods in that the formulation with self-consistency is better conditioned, suggesting SPIRiT to be a better candidate in k-space-based reconstruction. In this study, a general SPIRiT framework is adopted to incorporate both coil sensitivity and phase variation information as virtual coils and then is applied to 2D navigated iEPI diffusion imaging. To reduce the reconstruction time when using a large number of coils and shots, a novel shot-coil compression method is proposed for computation acceleration in Cartesian sampling. Simulations and in vivo experiments were conducted to evaluate the performance of the proposed method. Compared with the conventional coil compression, the shot-coil compression achieved higher compression rates with reduced errors. The simulation and in vivo experiments demonstrate that the SPIRiT-based reconstruction outperformed the existing method, realigned GRAPPA, and provided superior images with reduced artifacts. The SPIRiT-based reconstruction with virtual coil compression is a reliable method for high-resolution iEPI diffusion imaging. Magn Reson Med 79:1525-1531, 2018. © 2017 International Society for Magnetic Resonance in Medicine. © 2017 International Society for Magnetic Resonance in Medicine.

  7. Transmission of epi-alleles with MET1-dependent dense methylation in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Michael Watson

    Full Text Available DNA methylation in plants targets cytosines in three sequence contexts, CG, CHG and CHH (H representing A, C or T. Each of these patterns has traditionally been associated with distinct DNA methylation pathways with CHH methylation being controlled by the RNA dependent DNA methylation (RdDM pathway employing small RNAs as a guide for the de novo DOMAINS REARRANGED METHYLTRANSFERASE (DRM2, and maintenance DNA METHYLTRANSFERASE1 (MET1 being responsible for faithful propagation of CG methylation. Here we report an unusual 'dense methylation' pattern under the control of MET1, with methylation in all three sequence contexts. We identified epi-alleles of dense methylation at a non coding RNA locus (At4g15242 in Arabidopsis ecotypes, with distinct dense methylation and expression characteristics, which are stably maintained and transmitted in genetic crosses and which can be heritably altered by depletion of MET1. This suggests that, in addition to its classical CG maintenance function, at certain loci MET1 plays a role in creating transcriptional diversity based on the generation of independent epi-alleles. Database inspection identified several other loci with MET1-dependent dense methylation patterns. Arabidopsis ecotypes contain distinct epi-alleles of these loci with expression patterns that inversely correlate with methylation density, predominantly within the transcribed region. In Arabidopsis, dense methylation appears to be an exception as it is only found at a small number of loci. Its presence does, however, highlight the potential for MET1 as a contributor to epigenetic diversity, and it will be interesting to investigate the representation of dense methylation in other plant species.

  8. (Epi)genotype-Phenotype Analysis in 69 Japanese Patients With Pseudohypoparathyroidism Type I

    Science.gov (United States)

    Sano, Shinichiro; Nakamura, Akie; Matsubara, Keiko; Nagasaki, Keisuke; Fukami, Maki; Kagami, Masayo

    2018-01-01

    Context: Pseudohypoparathyroidism type I (PHP-I) is divided into PHP-Ia with Albright hereditary osteodystrophy and PHP-Ib, which usually shows no Albright hereditary osteodystrophy features. Although PHP-Ia and PHP-Ib are typically caused by genetic defects involving α subunit of the stimulatory G protein (Gsα)–coding GNAS exons and methylation defects of the GNAS differentially methylated regions (DMRs) on the maternal allele, respectively, detailed phenotypic characteristics still remains to be examined. Objective: To clarify phenotypic characteristics according to underlying (epi)genetic causes. Patients and Methods: We performed (epi)genotype-phenotype analysis in 69 Japanese patients with PHP-I; that is, 28 patients with genetic defects involving Gsα-coding GNAS exons (group 1) consisting of 12 patients with missense variants (subgroup A) and 16 patients with null variants (subgroup B), as well as 41 patients with methylation defects (group 2) consisting of 21 patients with broad methylation defects of the GNAS-DMRs (subgroup C) and 20 patients with an isolated A/B-DMR methylation defect accompanied by the common STX16 microdeletion (subgroup D). Results: Although (epi)genotype-phenotype findings were grossly similar to those reported previously, several important findings were identified, including younger age at hypocalcemic symptoms and higher frequencies of hyperphosphatemia in subgroup C than in subgroup D, development of brachydactyly in four patients of subgroup C, predominant manifestation of subcutaneous ossification in subgroup B, higher frequency of thyrotropin resistance in group 1 than in group 2, and relatively low thyrotropin values in four patients with low T4 values and relatively low luteinizing hormone/follicle-stimulating hormone values in five adult females with ovarian dysfunction. Conclusion: The results imply the presence of clinical findings characteristic of each underlying cause and provide useful information on the imprinting

  9. IMGT/GeneInfo: enhancing V(D)J recombination database accessibility

    OpenAIRE

    Baum, Thierry-Pascal; Pasqual, Nicolas; Thuderoz, Florence; Hierle, Vivien; Chaume, Denys; Lefranc, Marie-Paule; Jouvin-Marche, Evelyne; Marche, Patrice-Noël; Demongeot, Jacques

    2004-01-01

    IMGT/GeneInfo is a user-friendly online information system that provides information on data resulting from the complex mechanisms of immunoglobulin (IG) and T cell receptor (TR) V(D)J recombinations. For the first time, it is possible to visualize all the rearrangement parameters on a single page. IMGT/GeneInfo is part of the international ImMunoGeneTics information system® (IMGT), a high-quality integrated knowledge resource specializing in IG, TR, major histocompatibility complex (MHC), an...

  10. TU-H-206-07: Assessment of Geometric Distortion in EPI with a SPAMM Tagged Acquisition

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, K; Meier, J; Yung, J; Stafford, R [The University of Texas MD Anderson Cancer Center, Houston, TX (United States)

    2016-06-15

    Purpose: Echo planar imaging (EPI) is known to exhibit gross geometric distortion caused by multiple factors, including B0 inhomgeneity and transient eddy currents. However, diffusion weighted (DW) EPI has become indispensable for diagnosis and therapy assessment. We propose a methodology for quantifying distortion in EPI sequences that does not require the use of dedicated spatial accuracy phantoms, enabling flexibility in phantom design for QA of distortion effects in EPI protocols. Methods: The proposed methodology utilizes a saturation technique known as Spatial Modulation of Magnetization (SPAMM) that tags the imaging subject with saturated grid lines. Originally intended for tracking cardiac motion, these grids are applied to assess differences between diffusion weighting directions and b-values, or against a more geometrically robust sequence such as fast spin echo (FSE). The saturation preparation sequence consists of binomially weighted (e.g. 1-3-3-1) pulses interleaved with gradient blips along the frequency encode direction, followed by the same sequence with gradient blips in the phase encode direction. Three phantoms were assessed with these sequences: a spherical head-sized phantom, a large shimming phantom, and a modified PET ACR phantom that included compartments of water, air, oil, and Teflon. Each phantom was acquired with three sequences using parameters from a clinically appropriate protocol (22 cm head or 46 cm abdomen): a conventional DW-EPI sequence (3 DW directions), and both the DW-EPI and FSE sequences with tagging. Differences in grid locations were visualized with minimum intensity projection between images, and measured using intersecting locations on the grids. Results: Grid lines were clearly visualized on tagged images and enabled quantification of distortions. Maximum eddy current induced errors of 10.8 to 14.8 mm were observed in areas away from isocenter with DW gradients applied in various directions. Conclusion: SPAMM tagging

  11. Software system safety

    Science.gov (United States)

    Uber, James G.

    1988-01-01

    Software itself is not hazardous, but since software and hardware share common interfaces there is an opportunity for software to create hazards. Further, these software systems are complex, and proven methods for the design, analysis, and measurement of software safety are not yet available. Some past software failures, future NASA software trends, software engineering methods, and tools and techniques for various software safety analyses are reviewed. Recommendations to NASA are made based on this review.

  12. [2H26]-1-epi-Cubenol, a completely deuterated natural product from Streptomyces griseus

    Directory of Open Access Journals (Sweden)

    Christian A. Citron

    2013-12-01

    Full Text Available During growth on fully deuterated medium the volatile terpene [2H26]-1-epi-cubenol was released by the actinomycete Streptomyces griseus. This compound represents the first completely deuterated terpene obtained by fermentation. Despite a few previous reports in the literature the operability of this approach to fully deuterated compounds is still surprising, because the strong kinetic isotope effect of deuterium is known to slow down all metabolic processes in living organisms. Potential applications of completely labelled compounds from natural sources in structure elucidation, biosynthetic or pharmacokinetic investigations are discussed.

  13. Spondylo-epi-metaphyseal dysplasia with joint laxity and severe, progressive kyphoscoliosis

    International Nuclear Information System (INIS)

    Beighton, P.

    1980-01-01

    Spondylo-epi-metaphyseal dysplasia with progressive, severe kyphoscoliosis and gross joint laxity is a distinctive entity. The clinical and radiographic manifestations of seven affected children are presented and it is concluded that this order is probably more common than previously suspected. Skeletal survey is indicated in all patients with infantile idiopathic scoliosis, kyphosis, or kyphoscoliosis. In this context, radiographic studies of the pelvis may be of great diagnostic value. Referal for expert orhtopaedic management is essential for all patients with this disorder, as profound disability with pulmonary and spinal complications may be expected. (orig./MG) [de

  14. Epi-Side-Down Mounting of Interband Cascade Lasers for Army Applications

    Science.gov (United States)

    2006-11-01

    retain the principal advantage of electron recycling . However, unlike the QCL, the ICL relies on the cascading of interband optical transitions as...9.0 Cu 393 17 SiC 120 4 AlN 230 (high grade –Tsekoun 2006) 4.5, 4.3 Indium 83.7 24.8@ 20C 2 device ridge and an effective heat spreader ...65.3 K/W M271 epi-side down 8-μm x 1-mm mesa TmaxCW= 212K 4 were vital and survived multiple cryogenic to room temperature recyclings . Fig. 4

  15. Spondylo-epi-metaphyseal dysplasia with joint laxity and severe, progressive kyphoscoliosis

    Energy Technology Data Exchange (ETDEWEB)

    Beighton, P.; Kozlowski, K.

    1980-01-01

    Spondylo-epi-metaphyseal dysplasia with progressive, severe kyphoscoliosis and gross joint laxity is a distinctive entity. The clinical and radiographic manifestations of seven affected children are presented and it is concluded that this disorder is probably more common than previously suspected. Skeletal survey is indicated in all patients with infantile idiopathic scoliosis, kyphosis, or kyphoscoliosis. In this context, radiographic studies of the pelvis may be of great diagnostic value. Referal for expert orthopaedic management is essential for all patients with this disorder, as profound disability with pulmonary and spinal complications may be expected.

  16. Designing the Expanded Programme on Immunisation (EPI) as a service: Prioritising patients over administrative logic

    DEFF Research Database (Denmark)

    McKnight, J.; Holt, D. B.

    2014-01-01

    -the-ground problems that mothers face in trying to vaccinate their children, while instead prioritising administrative processes. Our ethnographic analysis of 83 mothers who had not vaccinated their children reveals key barriers to vaccination from a 'customer' perspective. While mothers value vaccination......Expanded Programme on Immunisation (EPI) vaccination rates remain well below herd immunity in regions of many countries despite huge international resources devoted to both financing and access. We draw upon service marketing theory, organisational sociology, development anthropology and cultural...... specific service problems from the mother's perspective and points towards simple service innovations that could improve vaccination rates in regions that have poor uptake....

  17. Skilled antenatal care service utilization and its association with the ...

    African Journals Online (AJOL)

    Data were entered into EPI info version 7 statistical software and exported to STATA ... Conclusions: Skilled ANC service utilization is the joint effect of individual and ... analysis, skilled antenatal care service, women's health development team ...

  18. An Audit of Endometrial Hyperplasias at the Lagos University ...

    African Journals Online (AJOL)

    2017-10-26

    Oct 26, 2017 ... Materials and Methods: The slides and request forms of cases diagnosed ... while reflecting, at the same time, the current understanding of genetic changes that ... The Epi Info version 7.1.4.0 statistical software was used.

  19. EAMJ May Lymphomas.indd

    African Journals Online (AJOL)

    2009-05-05

    May 5, 2009 ... Request for reprints to: Dr. S. Kalungi, Makerere University College of Health Sciences, P. O. ... Background: There are numerous reports from different countries documenting a change .... using the Epi-info software package.

  20. Contraceptive methods awareness and use among women of ...

    African Journals Online (AJOL)

    Contraceptive methods awareness and use among women of reproductive age in an urban ... aged 15-49 years in a Local Council Development Area (LCDA) of Lagos, Nigeria. ... Data analysis was done using Epi InfoTM statistical software.

  1. High resolution T{sub 2}{sup *}-weighted magnetic resonance imaging at 3 Tesla using PROPELLER-EPI

    Energy Technology Data Exchange (ETDEWEB)

    Kraemer, Martin; Reichenbach, Juergen R. [Jena University Hospital (Germany). Medical Physics Group

    2014-09-01

    We report the application of PROPELLER-EPI for high resolution T{sub 2}{sup *}-weighted imaging with sub-millimeter in-plane resolution on a clinical 3 Tesla scanner. Periodically rotated blades of a long-axis PROPELLER-EPI sequence were acquired with fast gradient echo readout and acquisition matrix of 320 x 50 per blade. Images were reconstructed by using 2D-gridding, phase and geometric distortion correction and compensation of resonance frequency drifts that occurred during extended measurements. To characterize these resonance frequency offsets, short FID calibration measurements were added to the PROPELLER-EPI sequence. Functional PROPELLER-EPI was performed with volunteers using a simple block design of right handed finger tapping. Results indicate that PROPELLER-EPI can be employed for fast, high resolution T{sub 2}{sup *}-weighted imaging provided geometric distortions and possible resonance frequency drifts are properly corrected. Even small resonance frequency drifts below 10 Hz as well as non-corrected geometric distortions degraded image quality substantially. In the initial fMRI experiment image quality and signal-to-noise ratio was sufficient for obtaining high resolution functional activation maps. (orig.)

  2. Vastukäiv info Liibanoni haarangu asjus tekitas kuhjaga segadust / Inga Höglund

    Index Scriptorium Estoniae

    Höglund, Inga

    2011-01-01

    Liibanoni julgeolekujõud lükkasid osaliselt ümber päeva jooksul tulnud info Bekaa orus Eesti turistide röövimise asjaoludest ja röövijatest. Operatsioon röövlite tabamiseks.Tulisemad inimröövikohad. Viimase aja tuntumaid pantvange

  3. InfoAccess - platform for the distribution of Southern African information

    CSIR Research Space (South Africa)

    Mc

    1993-01-01

    Full Text Available stream_source_info McGillivray_1993.pdf.txt stream_content_type text/plain stream_size 3 Content-Encoding ISO-8859-1 stream_name McGillivray_1993.pdf.txt Content-Type text/plain; charset=ISO-8859-1 ...

  4. 76 FR 6468 - Versar, Tetrahedron, Inc. and Info Impact; Transfer of Data

    Science.gov (United States)

    2011-02-04

    ..., to fulfill the obligations of the contract. DATES: Versar and its subcontractors, Tetrahedron, Inc... subcontractors, Tetrahedron, Inc. and Info Impact, have been awarded a contract to perform work for OPP, and.... II. Contractor Requirements Under Contract No. EP-W-11-007, Versar and its subcontractors...

  5. 77 FR 4815 - Ace Info Solutions, Inc., and Information International Associates; Transfer of Data

    Science.gov (United States)

    2012-01-31

    ... Confidential Business Information (CBI) by the submitter, will be transferred to Ace Info Solutions, Inc., and... Chemical Libraries and Repository; 4. Information architecture support, consultation on site structure and..., Business and industry, Government contracts, Government property, Security measures. Dated: January 19...

  6. Estimating glomerular filtration rate using the new CKD-EPI equation and other equations in patients with autosomal dominant polycystic kidney disease

    DEFF Research Database (Denmark)

    Orskov, Bjarne; Borresen, Malene L; Feldt-Rasmussen, Bo

    2010-01-01

    (CKD-EPI) equation, the Cockcroft-Gault equation adjusted for body surface area and the MDRD equation with cystatin C. Performance was evaluated by mean bias, precision and accuracy. RESULTS: The MDRD equation with cystatin C had 97% of GFR estimates within 30% of measured GFR (accuracy). Both the CKD-EPI....... The CKD-EPI or the Cockcroft-Gault equations showed better performance compared to the 4-variable MDRD equation....

  7. Nikkaji Dictionary: 4-epi-オキシテトラサイクリン [MeCab user dictionary for science technology term[Archive

    Lifescience Database Archive (English)

    Full Text Available MeCab user dictionary for science technology term 4-epi-オキシテトラサイクリン 名詞 一般 * * * * 4-epi-オキシテトラサイクリン... ... Nikkaji J735.319G 200906072936780617 C CA06 UNKNOWN_2 4 - epi - オキシテトラサイクリン

  8. EpiTools: An Open-Source Image Analysis Toolkit for Quantifying Epithelial Growth Dynamics.

    Science.gov (United States)

    Heller, Davide; Hoppe, Andreas; Restrepo, Simon; Gatti, Lorenzo; Tournier, Alexander L; Tapon, Nicolas; Basler, Konrad; Mao, Yanlan

    2016-01-11

    Epithelia grow and undergo extensive rearrangements to achieve their final size and shape. Imaging the dynamics of tissue growth and morphogenesis is now possible with advances in time-lapse microscopy, but a true understanding of their complexities is limited by automated image analysis tools to extract quantitative data. To overcome such limitations, we have designed a new open-source image analysis toolkit called EpiTools. It provides user-friendly graphical user interfaces for accurately segmenting and tracking the contours of cell membrane signals obtained from 4D confocal imaging. It is designed for a broad audience, especially biologists with no computer-science background. Quantitative data extraction is integrated into a larger bioimaging platform, Icy, to increase the visibility and usability of our tools. We demonstrate the usefulness of EpiTools by analyzing Drosophila wing imaginal disc growth, revealing previously overlooked properties of this dynamic tissue, such as the patterns of cellular rearrangements. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  9. Phylogenetically diverse macrophyte community promotes species diversity of mobile epi-benthic invertebrates

    Science.gov (United States)

    Nakamoto, Kenta; Hayakawa, Jun; Kawamura, Tomohiko; Kodama, Masafumi; Yamada, Hideaki; Kitagawa, Takashi; Watanabe, Yoshiro

    2018-07-01

    Various aspects of plant diversity such as species diversity and phylogenetic diversity enhance the species diversity of associated animals in terrestrial systems. In marine systems, however, the effects of macrophyte diversity on the species diversity of associated animals have received little attention. Here, we sampled in a subtropical seagrass-seaweed mixed bed to elucidate the effect of the macrophyte phylogenetic diversity based on the taxonomic relatedness as well as the macrophyte species diversity on species diversity of mobile epi-benthic invertebrates. Using regression analyses for each macrophyte parameter as well as multiple regression analyses, we found that the macrophyte phylogenetic diversity (taxonomic diversity index: Delta) positively influenced the invertebrate species richness and diversity index (H‧). Although the macrophyte species richness and H‧ also positively influenced the invertebrate species richness, the best fit model for invertebrate species richness did not include them, suggesting that the macrophyte species diversity indirectly influenced invertebrate species diversity. Possible explanations of the effects of macrophyte Delta on the invertebrate species diversity were the niche complementarity effect and the selection effect. This is the first study which demonstrates that macrophyte phylogenetic diversity has a strong effect on the species diversity of mobile epi-benthic invertebrates.

  10. EFFECT OF MOLECULAR WEIGHT ON THE YIELD BEHAVIOUR OF EPY EPOXY COMPOUND

    Directory of Open Access Journals (Sweden)

    Magdalena Urbaniak

    2016-12-01

    Full Text Available A series of epoxy networks with molecular weight between crosslinks (Mc ranging from 117 to 508 g/mol were investigated by employing as DSC and DMA methods and compression testing over a broad range of test temperatures (from 20 to 120 °C and strain rates (from 0.0208 to 20.8 min–1. Mechanical characteristics vs. testing temperature and strain rate developed in relation to working conditions of EPY compound applied for machine foundation chocks as well as effect of crosslinking on glass transition temperature (Tg presented in this paper let to find out the effect of molecular architecture composed chiefly by Mc on the thermal and mechanical properties that govern yield behaviour of the material. The investigations carried out in a.m. ranges of testing temperatures and strain rates showed that whichever change of Mc is related to the change in crosslink density causing relative shift in the Tg of the compound. However, a sensitivity of the polymer material on changes in strain rate falls down with growth of testing temperature. Obtained results prove that yielding in EPY compound can be examined in categories of the Eyring’s plastic flow model in which yielding is described.

  11. Sampling strategies for subsampled segmented EPI PRF thermometry in MR guided high intensity focused ultrasound

    Science.gov (United States)

    Odéen, Henrik; Todd, Nick; Diakite, Mahamadou; Minalga, Emilee; Payne, Allison; Parker, Dennis L.

    2014-01-01

    Purpose: To investigate k-space subsampling strategies to achieve fast, large field-of-view (FOV) temperature monitoring using segmented echo planar imaging (EPI) proton resonance frequency shift thermometry for MR guided high intensity focused ultrasound (MRgHIFU) applications. Methods: Five different k-space sampling approaches were investigated, varying sample spacing (equally vs nonequally spaced within the echo train), sampling density (variable sampling density in zero, one, and two dimensions), and utilizing sequential or centric sampling. Three of the schemes utilized sequential sampling with the sampling density varied in zero, one, and two dimensions, to investigate sampling the k-space center more frequently. Two of the schemes utilized centric sampling to acquire the k-space center with a longer echo time for improved phase measurements, and vary the sampling density in zero and two dimensions, respectively. Phantom experiments and a theoretical point spread function analysis were performed to investigate their performance. Variable density sampling in zero and two dimensions was also implemented in a non-EPI GRE pulse sequence for comparison. All subsampled data were reconstructed with a previously described temporally constrained reconstruction (TCR) algorithm. Results: The accuracy of each sampling strategy in measuring the temperature rise in the HIFU focal spot was measured in terms of the root-mean-square-error (RMSE) compared to fully sampled “truth.” For the schemes utilizing sequential sampling, the accuracy was found to improve with the dimensionality of the variable density sampling, giving values of 0.65 °C, 0.49 °C, and 0.35 °C for density variation in zero, one, and two dimensions, respectively. The schemes utilizing centric sampling were found to underestimate the temperature rise, with RMSE values of 1.05 °C and 1.31 °C, for variable density sampling in zero and two dimensions, respectively. Similar subsampling schemes

  12. Sandia software guidelines: Software quality planning

    Energy Technology Data Exchange (ETDEWEB)

    1987-08-01

    This volume is one in a series of Sandia Software Guidelines intended for use in producing quality software within Sandia National Laboratories. In consonance with the IEEE Standard for Software Quality Assurance Plans, this volume identifies procedures to follow in producing a Software Quality Assurance Plan for an organization or a project, and provides an example project SQA plan. 2 figs., 4 tabs.

  13. Avoidable Software Procurements

    Science.gov (United States)

    2012-09-01

    software license, software usage, ELA, Software as a Service , SaaS , Software Asset...PaaS Platform as a Service SaaS Software as a Service SAM Software Asset Management SMS System Management Server SEWP Solutions for Enterprise Wide...delivery of full Cloud Services , we will see the transition of the Cloud Computing service model from Iaas to SaaS , or Software as a Service . Software

  14. Software engineering architecture-driven software development

    CERN Document Server

    Schmidt, Richard F

    2013-01-01

    Software Engineering: Architecture-driven Software Development is the first comprehensive guide to the underlying skills embodied in the IEEE's Software Engineering Body of Knowledge (SWEBOK) standard. Standards expert Richard Schmidt explains the traditional software engineering practices recognized for developing projects for government or corporate systems. Software engineering education often lacks standardization, with many institutions focusing on implementation rather than design as it impacts product architecture. Many graduates join the workforce with incomplete skil

  15. Use of the EpiNet database for observational study of status epilepticus in Auckland, New Zealand.

    Science.gov (United States)

    Bergin, Peter; Jayabal, Jayaganth; Walker, Elizabeth; Davis, Suzanne; Jones, Peter; Dalziel, Stuart; Yates, Kim; Thornton, Vanessa; Bennett, Patricia; Wilson, Kaisa; Roberts, Lynair; Litchfield, Rhonda; Te Ao, Braden; Parmer, Priya; Feigin, Valery; Jost, Jeremy; Beghi, Ettore; Rossetti, Andrea O

    2015-08-01

    The EpiNet project has been established to facilitate investigator-initiated clinical research in epilepsy, to undertake epidemiological studies, and to simultaneously improve the care of patients who have records created within the EpiNet database. The EpiNet database has recently been adapted to collect detailed information regarding status epilepticus. An incidence study is now underway in Auckland, New Zealand in which the incidence of status epilepticus in the greater Auckland area (population: 1.5 million) will be calculated. The form that has been developed for this study can be used in the future to collect information for randomized controlled trials in status epilepticus. This article is part of a Special Issue entitled "Status Epilepticus". Copyright © 2015 Elsevier Inc. All rights reserved.

  16. The software life cycle

    CERN Document Server

    Ince, Darrel

    1990-01-01

    The Software Life Cycle deals with the software lifecycle, that is, what exactly happens when software is developed. Topics covered include aspects of software engineering, structured techniques of software development, and software project management. The use of mathematics to design and develop computer systems is also discussed. This book is comprised of 20 chapters divided into four sections and begins with an overview of software engineering and software development, paying particular attention to the birth of software engineering and the introduction of formal methods of software develop

  17. Overview of the ID, EPI and REL tasks of BioNLP Shared Task 2011

    Directory of Open Access Journals (Sweden)

    Pyysalo Sampo

    2012-06-01

    Full Text Available Abstract We present the preparation, resources, results and analysis of three tasks of the BioNLP Shared Task 2011: the main tasks on Infectious Diseases (ID and Epigenetics and Post-translational Modifications (EPI, and the supporting task on Entity Relations (REL. The two main tasks represent extensions of the event extraction model introduced in the BioNLP Shared Task 2009 (ST'09 to two new areas of biomedical scientific literature, each motivated by the needs of specific biocuration tasks. The ID task concerns the molecular mechanisms of infection, virulence and resistance, focusing in particular on the functions of a class of signaling systems that are ubiquitous in bacteria. The EPI task is dedicated to the extraction of statements regarding chemical modifications of DNA and proteins, with particular emphasis on changes relating to the epigenetic control of gene expression. By contrast to these two application-oriented main tasks, the REL task seeks to support extraction in general by separating challenges relating to part-of relations into a subproblem that can be addressed by independent systems. Seven groups participated in each of the two main tasks and four groups in the supporting task. The participating systems indicated advances in the capability of event extraction methods and demonstrated generalization in many aspects: from abstracts to full texts, from previously considered subdomains to new ones, and from the ST'09 extraction targets to other entities and events. The highest performance achieved in the supporting task REL, 58% F-score, is broadly comparable with levels reported for other relation extraction tasks. For the ID task, the highest-performing system achieved 56% F-score, comparable to the state-of-the-art performance at the established ST'09 task. In the EPI task, the best result was 53% F-score for the full set of extraction targets and 69% F-score for a reduced set of core extraction targets, approaching a level

  18. Diffusion-weighted MRI of the Prostate: Advantages of Zoomed EPI with Parallel-transmit-accelerated 2D-selective Excitation Imaging

    Energy Technology Data Exchange (ETDEWEB)

    Thierfelder, Kolja M.; Scherr, Michael K.; Weiss, Jakob; Mueller-Lisse, Ullrich G.; Theisen, Daniel [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); Notohamiprodjo, Mike; Nikolaou, Konstantin [Ludwig-Maximilians-University Hospital Munich, Institute for Clinical Radiology, Munich (Germany); University Hospital Tuebingen, Department of Diagnostic and Interventional Radiology, Tuebingen (Germany); Dietrich, Olaf [Ludwig-Maximilians-University Hospital Munich, Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Munich (Germany); Pfeuffer, Josef [Siemens Healthcare, Application Development, Erlangen (Germany)

    2014-12-15

    The purpose of our study was to evaluate the use of 2D-selective, parallel-transmit excitation magnetic resonance imaging (MRI) for diffusion-weighted echo-planar imaging (pTX-EPI) of the prostate, and to compare it to conventional, single-shot EPI (c-EPI). The MRI examinations of 35 patients were evaluated in this prospective study. PTX-EPI was performed with a TX-acceleration factor of 1.7 and a field of view (FOV) of 150 x 90 mm{sup 2}, whereas c-EPI used a full FOV of 380 x 297 mm{sup 2}. Two readers evaluated three different aspects of image quality on 5-point Likert scales. To quantify distortion artefacts, maximum diameters and prostate volume were determined for both techniques and compared to T2-weighted imaging. The zoomed pTX-EPI was superior to c-EPI with respect to overall image quality (3.39 ± 0.62 vs 2.45 ± 0.67) and anatomic differentiability (3.29 ± 0.65 vs 2.41 ± 0.65), each with p < 0.0001. Artefacts were significantly less severe in pTX-EPI (0.93 ± 0.73 vs 1.49 ± 1.08), p < 0.001. The quantitative analysis yielded a higher agreement of pTX-EPI with T2-weighted imaging than c-EPI with respect to coronal (ICCs: 0.95 vs 0.93) and sagittal (0.86 vs 0.73) diameters as well as prostate volume (0.94 vs 0.92). Apparent diffusion coefficient (ADC) values did not differ significantly between the two techniques (p > 0.05). Zoomed pTX-EPI leads to substantial improvements in diffusion-weighted imaging (DWI) of the prostate with respect to different aspects of image quality and severity of artefacts. (orig.)

  19. Brief introduction of nuclear power plant emergency system EmInfoSys

    International Nuclear Information System (INIS)

    Xiao Yuhua; Zhao Zhigang

    2014-01-01

    Nuclear safety is the lifeline of nuclear energy and nuclear technology, nuclear accident emergency response is the last line of nuclear security defense, and is one of the important measures to ensure the healthy development of the nuclear energy safety. The establishment of complete function, sensitive reaction and efficient emergency management system for operation of nuclear and radiation accidents is an important task of nuclear security. From 2001 China Techenergy Co., Ltd. participated in the Qinshan, Tianwan, Ministry of Environmental Protection, Haiyang, Taishan, Fangchenggang, Sanmen, etc. nuclear emergency projects, and the nuclear emergency EmInfoSys (emergency management information system) platform was developed with independent intellectual property rights. A brief introduction about EmInfoSys system was performed in this paper. (authors)

  20. The total syntheses of guttiferone A and 6-epi-guttiferone A.

    Science.gov (United States)

    Horeischi, Fiene; Biber, Nicole; Plietker, Bernd

    2014-03-12

    Polyprenylated polycyclic acylphloroglucinols (PPAP) are a constantly growing class of natural products that exhibit a common bicyclo[3.3.1]nonatrione core and consist of currently more than 200 members. A subclassification among the various natural products of this class includes the position of the exocyclic acyl group, the prenylation grade of the core, and the relative configuration at C-7 within the core. About 10% of the reported structures, however, possess an additional chiral center at C-6. Herein we describe a straightforward access to guttiferone A and epi-guttiferone A, in which full control of stereoselectivity is achieved via conformational control, and a strict separation of framework decorating from framework constructing operations sets the stage for a short 13-step synthesis.

  1. [Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?].

    Science.gov (United States)

    Delanaye, Pierre; Mariat, Christophe; Moranne, Olivier; Cavalier, Etienne; Flamant, Martin

    2012-07-01

    Measuring or estimating glomerular filtration rate (GFR) is still considered as the best way to apprehend global renal function. In 2009, the new Chronic Kidney Disease Epidemiology (CKD-EPI) equation has been proposed as a better estimator of GFR than the Modification of Diet in Renal Disease (MDRD) study equation. This new equation is supposed to underestimate GFR to a lesser degree in higher GFR levels. In this review, we will present and deeply discuss the performances of this equation. Based on articles published between 2009 and 2012, this review will underline advantages, notably the better knowledge of chronic kidney disease prevalence, but also limitations of this new equation, especially in some specific populations. We eventually insist on the fact that all these equations are estimations and nephrologists should remain cautious in their interpretation. Copyright © 2012 Association Société de néphrologie. Published by Elsevier SAS. All rights reserved.

  2. New insights in oncology: Epi-genetics and cancer stem cells

    International Nuclear Information System (INIS)

    Krutovskikh, V.; Partensky, C.

    2011-01-01

    Cancer is a multi-etiologic, multistage disease with a prevalent genetic component, which happens when a large number of genes, critical for cell growth, death, differentiation, migration, and metabolic plasticity are altered irreversibly, so as to either 'gain' (oncogenes) or 'lose' (tumour suppressors) their function. Recent discoveries have revealed the previously underestimated etiologic importance of multiple epigenetic, that is to say, reversible factors (histone modifications, DNA methylation, non-coding RNA) involved in the transcriptional and post-transcriptional regulation of proteins, indispensable for the control of cancerous phenotype. Stable alterations of epigenetic machinery ('epi-mutations') turn out to play a critical role at different steps of carcinogenesis. In addition, due to substantial recent progress in stem cell biology, the new concept of cancer stem cells has emerged. This, along with newly discovered epigenetic cancer mechanisms, gives rise to a hope to overcome radio- and chemo-resistance and to eradicate otherwise incurable neoplasms. (authors)

  3. Development of ultra pure germanium epi layers for blocked impurity band far infrared detectors

    International Nuclear Information System (INIS)

    Lutz, M.P.

    1991-05-01

    The main goals of this paper are: (1) To develop a low-pressure CVD (LPCVD) process that allows epitaxial growth at lower temperatures. Lower temperatures will allow the achievement of a sharp dopant profile at the substrate/epi-layer interface. Less out-diffusion from the substrate would allow the use of thinner epitaxial layers, which would lead to a larger depletion width in the photoactive region. LPCVD also avoids, to a great extent, gas-phase nucleation, which would cause Ge particulates to fall onto the wafer surface during growth. (2) To reduce high levels of oxygen and copper present at the wafer interface, as observed by secondary ion mass spectroscopy (SIMS). In order to achieve high-quality epitaxial layers, it is imperative that the substrate surface be of excellent quality. (3) To make and test detectors, after satisfactory epitaxial layers have been made

  4. EpiPOD : community vaccination and dispensing model user's guide.

    Energy Technology Data Exchange (ETDEWEB)

    Berry, M.; Samsa, M.; Walsh, D.; Decision and Information Sciences

    2009-01-09

    EpiPOD is a modeling system that enables local, regional, and county health departments to evaluate and refine their plans for mass distribution of antiviral and antibiotic medications and vaccines. An intuitive interface requires users to input as few or as many plan specifics as are available in order to simulate a mass treatment campaign. Behind the input interface, a system dynamics model simulates pharmaceutical supply logistics, hospital and first-responder personnel treatment, population arrival dynamics and treatment, and disease spread. When the simulation is complete, users have estimates of the number of illnesses in the population at large, the number of ill persons seeking treatment, and queuing and delays within the mass treatment system--all metrics by which the plan can be judged.

  5. A new syndrome of 'spondylo-epi-metaphyseal dysplasia: mixed type''

    International Nuclear Information System (INIS)

    Sharma, B.G.

    2003-01-01

    A new type of rare bone dysplasia is described, which shares some common features with spondylo-meta-epiphyseal dysplasia: short limb-abnormal calcification type and lethal metatropic dysplasia. Besides these features, the present case has some additional unusual features. Facial malformation was very obvious and of a different type. The nose and nares were completely flattened. Hypertrophied acetabular bones, round densities on the ilia, premature ossification of many epiphyses and carpal bones, curvilinear calcifications in some joints, fusion of the ischiopubic rami, calcification of many costal cartilages and thick sclerotic base of the skull were a few of the significant findings. On the basis of the clinical and radiological features, the condition has been named ''spondylo-epi-metaphyseal dysplasia: mixed type''. (orig.)

  6. [Evaluation of Image Quality of Readout Segmented EPI with Readout Partial Fourier Technique].

    Science.gov (United States)

    Yoshimura, Yuuki; Suzuki, Daisuke; Miyahara, Kanae

    Readout segmented EPI (readout segmentation of long variable echo-trains: RESOLVE) segmented k-space in the readout direction. By using the partial Fourier method in the readout direction, the imaging time was shortened. However, the influence on image quality due to insufficient data sampling is concerned. The setting of the partial Fourier method in the readout direction in each segment was changed. Then, we examined signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), and distortion ratio for changes in image quality due to differences in data sampling. As the number of sampling segments decreased, SNR and CNR showed a low value. In addition, the distortion ratio did not change. The image quality of minimum sampling segments is greatly different from full data sampling, and caution is required when using it.

  7. Whole brain, high resolution multiband spin-echo EPI fMRI at 7 T: A comparison with gradient-echo EPI using a color-word Stroop task

    NARCIS (Netherlands)

    Boyacioglu, R.; Schulz, J.; Müller, N.C.J.; Koopmans, P.J.; Barth, M.; Norris, David Gordon

    2014-01-01

    A whole brain, multiband spin-echo (SE) echo planar imaging (EPI) sequence employing a high spatial (1.5 mm isotropic) and temporal (TR of 2 s) resolution was implemented at 7 T. Its overall performance (tSNR, sensitivity and CNR) was assessed and compared to a geometrically matched gradient-echo

  8. Validation study of the EORTC information questionnaire (EORTC QLQ-INFO25) in Iranian cancer patients.

    Science.gov (United States)

    Asadi-Lari, Mohsen; Ahmadi Pishkuhi, Mahin; Almasi-Hashiani, Amir; Safiri, Saeid; Sepidarkish, Mahdi

    2015-07-01

    Developing a tool for measuring patient's needs is a vital step in the process of cancer treatment and research. In recent years, the European Organization for Research and Treatment of Cancer (EORTC) made a questionnaire to measure cancer patients' received information. Since validity and reliability of any instrument should be evaluated in the new environment and culture, the aim of this study was to assess the validity and reliability of the EORTC QLQ-INFO25 in Iranian cancer patients. One hundred seventy-three patients with different stages of cancer filled questionnaire EORTC QLQ-INFO25, EORTC QLQ-C30, and EORTC IN-PATSAT32. Twenty-five patients answered the questionnaire twice at an interval of 2 weeks. Reliability and validity of the questionnaire was measured by Cronbach's alpha, interclass correlation, test retest, inter-rater agreement (IRA), and exploratory factorial analyses. Using a conservative approach, the IRA for the overall relevancy and clarity of the tool was 87/86% and 83.33%, respectively. Overall appropriateness and clarity were 94.13 and 91.87%, respectively. Overall integrity of the instrument was determined to be 85%. Cronbach's alpha coefficients for all domains and total inventory were top 70 and 90%, respectively. Interclass correlation index ranges between 0.708 and 0.965. Exploratory factorial analyses demonstrate six fields suitable for instrument. Correlation between areas of the questionnaires EORTC QLQ-INFO25 and EORTC in-Patsat32 represents the convergent validity of the questionnaire. Also, results show a standard divergent validity in all domains of the questionnaire (Rho validity of the questionnaire. The results showed that Persian version of the questionnaire EORTC QLQ-INFO25 is a reliable and valid instrument for measuring the perception of information in cancer patients.

  9. Post-Inpatient Brain Injury Rehabilitation Outcomes: Report from the National OutcomeInfo Database

    OpenAIRE

    Malec, James F.; Kean, Jacob

    2016-01-01

    This study examined outcomes for intensive residential and outpatient/community-based post-inpatient brain injury rehabilitation (PBIR) programs compared with supported living programs. The goal of supported living programs was stable functioning (no change). Data were obtained for a large cohort of adults with acquired brain injury (ABI) from the OutcomeInfo national database, a web-based database system developed through National Institutes of Health (NIH) Small Business Technology Transfer...

  10. THROUGH THE LOOKING-GLASS PsycINFO as an Historical Archive of Trends in Psychology.

    Science.gov (United States)

    Burman, Jeremy Trevelyan

    2018-02-05

    Those interested in tracking trends in the history of psychology cannot simply trust the numbers produced by inputting terms into search engines like PsycINFO and then constraining by date. This essay is therefore a critical engagement with that longstanding interest to show what it is possible to do, over what period, and why. It concludes that certain projects simply cannot be undertaken without further investment by the American Psychological Association. This is because forgotten changes in the assumptions informing the database make its index terms untrustworthy for use in trend-tracking before 1967. But they can indeed be used, with care, to track more recent trends. The result is then a Distant Reading of psychology, with Digital History presented as enabling a kind of Science Studies that psychologists will find appealing. The present state of the discipline can thus be caricatured as the contemporary scientific study of depressed rats and the drugs used to treat them (as well as of human brains, mice, and myriad other topics). To extend the investigation back further in time, however, the 1967 boundary is also investigated. The author then delves more deeply into the prehistory of the database's creation, and shows in a précis of a further project that the origins of PsycINFO can be traced to interests related to American national security during the Cold War. In short: PsycINFO cannot be treated as a simple bibliographic description of the discipline. It is embedded in its history, and reflects it. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

  11. The Job of 'Conseiller info energie': Small Uncertain Hands of the French Energy Policies

    International Nuclear Information System (INIS)

    Cacciari, Joseph

    2016-01-01

    This article examines the diffusion of the 'green economy' from the Conseiller info energie job, created in 2002. These advisors direct individuals in their proposed purchase of renewable energy equipment or energy renovation of their homes, to promote the 'greening' of the housing sector. From the story and position of this activity, we support the green economy is caught in uncertainty as to its effective institutionalization

  12. Informatsiooni globaliseerumine : arvutivõrkudega infoühiskond / Sirje Virkus

    Index Scriptorium Estoniae

    Virkus, Sirje, 1956-

    1997-01-01

    Grazis toimunud Rahvusvahelise Informatsiooni ja Dokumentatsiooni Liidu (FID) konverentsist ja kongressist. Peateemaks oli informatsiooni globaliseerumine arvutivõrkudega infoühiskonnas. FIDi hariduse ja koolituse komitee (FID/ET - FID Education and Training Committee) seminarist "Töötamine ja õppimine elektroonilises võrgukeskkonnas" ("Working and Learning in a Networked Electronic Environment"). Sirje Virkus Tallinna Pedagoogikaülikoolist andis seminaril ülevaate kaugkoolituse arengust Eestis ja TPÜ infoteaduste osakonnas

  13. Efflux pump inhibitors (EPIs as new antimicrobial agents against Pseudomonas aeruginosa

    Directory of Open Access Journals (Sweden)

    Momen Askoura

    2011-05-01

    Full Text Available Pseudomonas aeruginosa is an opportunistic human pathogen and one of the leading causes of nosocomial infections worldwide. The difficulty in treatment of pseudomonas infections arises from being multidrug resistant (MDR and exhibits resistance to most antimicrobial agents due to the expression of different mechanisms overcoming their effects. Of these resistance mechanisms, the active efflux pumps in Pseudomonas aeruginosa that belong to the resistance nodulation division (RND plays a very important role in extruding the antibiotics outside the bacterial cells providing a protective means against their antibacterial activity. Beside its role against the antimicrobial agents, these pumps can extrude biocides, detergents, and other metabolic inhibitors. It is clear that efflux pumps can be targets for new antimicrobial agents. Peptidomimetic compounds such as phenylalanine arginyl β-naphthylamide (PAβN have been introduced as efflux pump inhibitors (EPIs; their mechanism of action is through competitive inhibition with antibiotics on the efflux pump resulting in increased intracellular concentration of antibiotic, hence, restoring its antibacterial activity. The advantage of EPIs is the difficulty to develop bacterial resistance against them, but the disadvantage is their toxic property hindering their clinical application. The structure activity relationship of these compounds showed other derivatives from PAβN that are higher in their activity with higher solubility in biological fluids and decreased toxicity level. This raises further questions on how can we compact Pseudomonas infections. Of particular importance, the recent resurgence in the use of older antibiotics such as polymyxins and probably applying stricter control measures in order to prevent their spread in clinical sittings.

  14. 75 FR 82010 - AceInfo Solutions and Avaya Government Solutions, Koansys LLC, and Quality Associates Inc...

    Science.gov (United States)

    2010-12-29

    ... Associates Inc., to fulfill the obligations of the contract. DATES: AceInfo Solutions and its subcontractors... Inc. have been awarded a contract to perform work for OPP, and access to this information will enable... Contract No. GS-06F-0337Z, AceInfo Solutions and its subcontractors, Avaya Government Solutions, Koansys...

  15. ESTSC - Software Best Practices

    Science.gov (United States)

    DOE Scientific and Technical Software Best Practices December 2010 Table of Contents 1.0 Introduction 2.0 Responsibilities 2.1 OSTI/ESTSC 2.2 SIACs 2.3 Software Submitting Sites/Creators 2.4 Software Sensitivity Review 3.0 Software Announcement and Submission 3.1 STI Software Appropriate for Announcement 3.2

  16. Software Assurance Competency Model

    Science.gov (United States)

    2013-03-01

    COTS) software , and software as a service ( SaaS ). L2: Define and analyze risks in the acquisition of contracted software , COTS software , and SaaS ...2010a]: Application of technologies and processes to achieve a required level of confidence that software systems and services function in the...

  17. Software attribute visualization for high integrity software

    Energy Technology Data Exchange (ETDEWEB)

    Pollock, G.M.

    1998-03-01

    This report documents a prototype tool developed to investigate the use of visualization and virtual reality technologies for improving software surety confidence. The tool is utilized within the execution phase of the software life cycle. It provides a capability to monitor an executing program against prespecified requirements constraints provided in a program written in the requirements specification language SAGE. The resulting Software Attribute Visual Analysis Tool (SAVAnT) also provides a technique to assess the completeness of a software specification.

  18. Epi-detecting label-free multimodal imaging platform using a compact diode-pumped femtosecond solid-state laser

    DEFF Research Database (Denmark)

    Andreana, Marco; Le, Tuan; Hansen, Anders Kragh

    2017-01-01

    We have developed an epi-detected multimodal nonlinear optical microscopy platform based on a compact and cost-effective laser source featuring simultaneous acquisition of signals arising from hyperspectral coherent anti-Stokes Raman scattering (CARS), two-photon fluorescence, and second harmonic...

  19. El Grupo ThinkEPI: un think tank en información y documentación

    OpenAIRE

    Orduña-Malea, Enrique; Guallar, Javier; Baiget, Tomàs

    2009-01-01

    We present the main features, goals, publishing system and debating procedure of the Spanish think tank on Library and Information Science ThinkEPI Group (Information Strategy and Prospective). We analyse its scientific output, author's productivity, comments received, subject coverage and its web site audience.

  20. Thermal stability of Ni-Pt-Ta alloy silicides on epi-Si{sub 1-x}C{sub x}

    Energy Technology Data Exchange (ETDEWEB)

    Yoo, Jung-Ho; Chang, Hyun-Jin [Department of Ceramic Engineering, Yonsei University, Seoul 120-749 (Korea, Republic of); Min, Byoung-Gi [Department of Ceramic Engineering, Yonsei University, Seoul 120-749 (Korea, Republic of); Jusung Engineering Co., Ltd., 49, Neungpyeong-ri, Opo-eup, Gwangju-Si, Kyunggi-do 464-892 (Korea, Republic of); Ko, Dae-Hong [Department of Ceramic Engineering, Yonsei University, Seoul 120-749 (Korea, Republic of)], E-mail: dhko@yonsei.ac.kr; Cho, Mann-Ho [Institute of Physics and Applied Physics, Yonsei University, Seoul 120-749 (Korea, Republic of); Sohn, Hyunchul [Department of Ceramic Engineering, Yonsei University, Seoul 120-749 (Korea, Republic of); Lee, Tae-Wan [Jusung Engineering Co., Ltd., 49, Neungpyeong-ri, Opo-eup, Gwangju-Si, Kyunggi-do 464-892 (Korea, Republic of)

    2008-12-05

    We investigated the silicide formation in Ni/epi-Si{sub 1-x}C{sub x} systems. Ni-Pt and Ni-Pt-Ta films were deposited on epi-Si{sub 1-x}C{sub x}/Si substrates by DC magnetron sputtering and processed at various temperatures. The sheet resistance of the silicide from the Ni alloy/epi-Si{sub 1-x}C{sub x} systems was maintained at low values compared to that from Ni/Si systems. By TEM and EDS analyses, we confirmed the presence of a Pt alloy layer at the top of the Ni-silicide layer. The stability of the silicide layer in the Ni alloy/epi-Si{sub 1-x}C{sub x} system is explained by not only the Pt rich layer on the top of the Ni-silicide layer, but also by the presence of a small amount of Pt in the Ni-silicide layer or at the grain boundaries. And both the thermal stability and the morphology of silicide were greatly improved by the addition of Ta in Ni-Pt films.

  1. Thermal stability of Ni-Pt-Ta alloy silicides on epi-Si1-xCx

    International Nuclear Information System (INIS)

    Yoo, Jung-Ho; Chang, Hyun-Jin; Min, Byoung-Gi; Ko, Dae-Hong; Cho, Mann-Ho; Sohn, Hyunchul; Lee, Tae-Wan

    2008-01-01

    We investigated the silicide formation in Ni/epi-Si 1-x C x systems. Ni-Pt and Ni-Pt-Ta films were deposited on epi-Si 1-x C x /Si substrates by DC magnetron sputtering and processed at various temperatures. The sheet resistance of the silicide from the Ni alloy/epi-Si 1-x C x systems was maintained at low values compared to that from Ni/Si systems. By TEM and EDS analyses, we confirmed the presence of a Pt alloy layer at the top of the Ni-silicide layer. The stability of the silicide layer in the Ni alloy/epi-Si 1-x C x system is explained by not only the Pt rich layer on the top of the Ni-silicide layer, but also by the presence of a small amount of Pt in the Ni-silicide layer or at the grain boundaries. And both the thermal stability and the morphology of silicide were greatly improved by the addition of Ta in Ni-Pt films

  2. MDRD vs. CKD-EPI in comparison to 51Chromium EDTA: a cross sectional study of Malaysian CKD cohort.

    Science.gov (United States)

    Jalalonmuhali, Maisarah; Lim, Soo Kun; Md Shah, Mohammad Nazri; Ng, Kok Peng

    2017-12-13

    Accurate measurement of renal function is important: however, radiolabelled gold standard measurement of GFR is highly expensive and can only be used on a very limited scale. We aim to compare the performance of Modification of Diet in Renal Disease (MDRD) and Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) equations in the multi-ethnic population attending University Malaya Medical Centre (UMMC). This is a cross-sectional study recruiting patients, who attend UMMC Nephrology clinics on voluntary basis. 51-Chromium EDTA ( 51 Cr-EDTA) plasma level was used to measure the reference GFR. The serum creatinine was determined by IDMS reference modified Jaffe kinetic assay (Cr Jaffe ). The predictive capabilities of MDRD and CKD-EPI based equations were calculated. Data was analysed using SPSS version 20 and correlation, bias, precision and accuracy were determined. A total of 113 subjects with mean age of 58.12 ± 14.76 years and BMI of 25.99 ± 4.29 kg/m 2 were recruited. The mean reference GFR was 66.98 ± 40.65 ml/min/1.73m 2 , while the estimated GFR based on MDRD and CKD-EPI formula were 62.17 ± 40.40, and 60.44 ± 34.59, respectively. Both MDRD and CKD-EPI were well-correlated with reference GFR (0.806 and 0.867 respectively) and statistically significant with p < 0.001. In the overall cohort, although MDRD had smaller bias than CKD-EPI (4.81 vs. 6.54), CKD-EPI was more precise (25.22 vs. 20.29) with higher accuracy within 30% of measured GFR (79.65 vs. 86.73%). The CKD-EPI equation appeared to be more precise and accurate than the MDRD equation in estimating GFR in our cohort of multi-ethnic populations in Malaysia.

  3. Reliability of software

    International Nuclear Information System (INIS)

    Kopetz, H.

    1980-01-01

    Common factors and differences in the reliability of hardware and software; reliability increase by means of methods of software redundancy. Maintenance of software for long term operating behavior. (HP) [de

  4. Space Flight Software Development Software for Intelligent System Health Management

    Science.gov (United States)

    Trevino, Luis C.; Crumbley, Tim

    2004-01-01

    The slide presentation examines the Marshall Space Flight Center Flight Software Branch, including software development projects, mission critical space flight software development, software technical insight, advanced software development technologies, and continuous improvement in the software development processes and methods.

  5. Software Engineering Guidebook

    Science.gov (United States)

    Connell, John; Wenneson, Greg

    1993-01-01

    The Software Engineering Guidebook describes SEPG (Software Engineering Process Group) supported processes and techniques for engineering quality software in NASA environments. Three process models are supported: structured, object-oriented, and evolutionary rapid-prototyping. The guidebook covers software life-cycles, engineering, assurance, and configuration management. The guidebook is written for managers and engineers who manage, develop, enhance, and/or maintain software under the Computer Software Services Contract.

  6. Enantioselective total synthesis of (+)-brefeldin A and 7-epi-brefeldin A.

    Science.gov (United States)

    Wu, Yikang; Shen, Xin; Yang, Yong-Qing; Hu, Qi; Huang, Jia-Hui

    2004-05-28

    A convergent enantioselective route to brefeldin A (BFA) and 7-epi-BFA was developed. The key C-4/C-5 chiral centers were established by using chiral auxiliary induced intermolecular asymmetric aldolization in the presence of TiCl(4) and TMEDA. The results with the thiazolidinethione/TiCl(4) mediated intermolecular asymmetric aldolization added some new information about the scope and limitations to the existing knowledge of that type of reactions (which so far was essentially limited to the reactions with N-propionyl thiazolidinethiones). During the course a method for protecting the liable aldol hydroxyl groups by using inexpensive TBSCl in DMF with 2,6-lutidine as the base was developed to replace the otherwise unavoidable TBSOTf procedure. Due to the excessive steric hindrance, removal of the auxiliary was much more difficult than most literature cases. Cleavage of the oxazolidinone by reduction was almost impossible. The thiazolidinethione auxiliary was relatively easier to remove. However, several reactions reported for facile removal of thiazolidinethione auxiliaries in the literature still failed. Reductive removal of the thiazolidinethione auxiliary was most effectively realized with LiBH(4) in diethyl ether in the presence of 1 equiv of MeOH (a modification of a literature procedure for removal of oxazolidinone auxiliaries in less hindered substrates). Apart from the auxiliary removal, oxidation of the alcohol into aldehyde and the deprotection of the dithiolane protecting group were also rather difficult in the present context. A range of methods were screened before final solutions were found. The five-membered ring was constructed by employing an intramolecular Mukaiyama reaction after many attempts with the intramolecular aldolization under a variety of conditions failed. The rate of elimination of the alkoxyl to form the alpha,beta-double bond of the key intermediate cyclopentenone 49 with DBU was highly solvent dependent (very sluggish in CH(2)Cl(2

  7. The EORTC information questionnaire, EORTC QLQ-INFO25. Validation study for Spanish patients.

    Science.gov (United States)

    Arraras, Juan Ignacio; Manterola, Ana; Hernández, Berta; Arias de la Vega, Fernando; Martínez, Maite; Vila, Meritxell; Eito, Clara; Vera, Ruth; Domínguez, Miguel Ángel

    2011-06-01

    The EORTC QLQ-INFO25 evaluates the information received by cancer patients. This study assesses the psychometric properties of the QLQ-INFO25 when applied to a sample of Spanish patients. A total of 169 patients with different cancers and stages of disease completed the EORTC QLQINFO25, the EORTC QLQ-C30 and the information scales of the inpatient satisfaction module EORTC IN-PATSAT32 on two occasions during the patients' treatment and follow- up period. Psychometric evaluation of the structure, reliability, validity and responsiveness to changes was conducted. Patient acceptability was assessed with a debriefing questionnaire. Multi-trait scaling confirmed the 4 multi-item scales (information about disease, medical tests, treatment and other services) and eight single items. All items met the standards for convergent validity and all except one met the standards of item discriminant validity. Internal consistency for all scales (α>0.70) and the whole questionnaire (α>0.90) was adequate in the three measurements, except information about the disease (0.67) and other services (0.68) in the first measurement, as was test-retest reliability (intraclass correlations >0.70). Correlations with related areas of IN-PATSAT32 (r>0.40) supported convergent validity. Divergent validity was confirmed through low correlations with EORTC QLQ-C30 scales (rinformation and satisfaction. One scale and an item showed changes over time. The EORTC QLQ-INFO 25 is a reliable and valid instrument when applied to a sample of Spanish cancer patients. These results are in line with those of the EORTC validation study.

  8. www.PedRad.info, the first bilingual case-oriented publication platform for pediatric radiology

    International Nuclear Information System (INIS)

    Hirsch, Wolfgang; Paetzel, Martina; Talanow, Roland

    2005-01-01

    On the Internet, there are few pediatric radiology databases. The most important and complete Web site is PediatricRadiology.com, which provides many radiological links but does not have its own database. We present an Internet project called PedRad.info (also known as Kinderradiologie-Online). The open-source, case-oriented publication platform publishes validated pediatric radiology findings on the Internet. A comparable on-line program, even for adult radiology, does not exist, so this tool is a pioneer in the area of Web-based information technology for medical and radiological communities. (orig.)

  9. CONVERGENCE OF NANO-, BIO-, INFO-, COGNITIVE TECHNOLOGIES AND E-CULTURE

    Directory of Open Access Journals (Sweden)

    Sergey I. Rodzin

    2014-01-01

    Full Text Available The article analyzes the convergence of nano-, bio-, info- and cognitive technologies. We highlight the close relationship of such notions as “e-culture”, “consciousness”, “artificial intelligence”. Artificial intelligence technology is the meta-NBIC-complex itself. Electronic infrastructure of intellectual activity - the essence of artificial intelligence and artificial intelligence technologies play a meta-level role of NBIC- technologies, being significant for e-culture. Development of science, technology, and education suggests that in the future perhaps a radical transformation in human beings is not only the material world, but also a subjective reality. 

  10. Ensuring Software IP Cleanliness

    Directory of Open Access Journals (Sweden)

    Mahshad Koohgoli

    2007-12-01

    Full Text Available At many points in the life of a software enterprise, determination of intellectual property (IP cleanliness becomes critical. The value of an enterprise that develops and sells software may depend on how clean the software is from the IP perspective. This article examines various methods of ensuring software IP cleanliness and discusses some of the benefits and shortcomings of current solutions.

  11. Commercial Literacy Software.

    Science.gov (United States)

    Balajthy, Ernest

    1997-01-01

    Presents the first year's results of a continuing project to monitor the availability of software of relevance for literacy education purposes. Concludes there is an enormous amount of software available for use by teachers of reading and literacy--whereas drill-and-practice software is the largest category of software available, large numbers of…

  12. Ensuring Software IP Cleanliness

    OpenAIRE

    Mahshad Koohgoli; Richard Mayer

    2007-01-01

    At many points in the life of a software enterprise, determination of intellectual property (IP) cleanliness becomes critical. The value of an enterprise that develops and sells software may depend on how clean the software is from the IP perspective. This article examines various methods of ensuring software IP cleanliness and discusses some of the benefits and shortcomings of current solutions.

  13. Statistical Software Engineering

    Science.gov (United States)

    1998-04-13

    multiversion software subject to coincident errors. IEEE Trans. Software Eng. SE-11:1511-1517. Eckhardt, D.E., A.K Caglayan, J.C. Knight, L.D. Lee, D.F...J.C. and N.G. Leveson. 1986. Experimental evaluation of the assumption of independence in multiversion software. IEEE Trans. Software

  14. Agile Software Development

    Science.gov (United States)

    Biju, Soly Mathew

    2008-01-01

    Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on…

  15. Improving Software Developer's Competence

    DEFF Research Database (Denmark)

    Abrahamsson, Pekka; Kautz, Karlheinz; Sieppi, Heikki

    2002-01-01

    Emerging agile software development methods are people oriented development approaches to be used by the software industry. The personal software process (PSP) is an accepted method for improving the capabilities of a single software engineer. Five original hypotheses regarding the impact...

  16. Software - Naval Oceanography Portal

    Science.gov (United States)

    are here: Home › USNO › Earth Orientation › Software USNO Logo USNO Navigation Earth Orientation Products GPS-based Products VLBI-based Products EO Information Center Publications about Products Software Search databases Auxiliary Software Supporting Software Form Folder Earth Orientation Matrix Calculator

  17. Software Engineering Education Directory

    Science.gov (United States)

    1990-04-01

    and Engineering (CMSC 735) Codes: GPEV2 * Textiooks: IEEE Tutoria on Models and Metrics for Software Management and Engameeing by Basi, Victor R...Software Engineering (Comp 227) Codes: GPRY5 Textbooks: IEEE Tutoria on Software Design Techniques by Freeman, Peter and Wasserman, Anthony 1. Software

  18. Great software debates

    CERN Document Server

    Davis, A

    2004-01-01

    The industry’s most outspoken and insightful critic explains how the software industry REALLY works. In Great Software Debates, Al Davis, shares what he has learned about the difference between the theory and the realities of business and encourages you to question and think about software engineering in ways that will help you succeed where others fail. In short, provocative essays, Davis fearlessly reveals the truth about process improvement, productivity, software quality, metrics, agile development, requirements documentation, modeling, software marketing and sales, empiricism, start-up financing, software research, requirements triage, software estimation, and entrepreneurship.

  19. Design and Development of Nonlinear Optical Microscope System: Simple Implementation with epi-Illumination Platform

    Directory of Open Access Journals (Sweden)

    Ryu Jiheun

    2015-01-01

    Full Text Available During the research using fluorescence-tagged or auto-fluorescence molecules, meaningful information is often buried deep inside the tissue, not its surface. Therefore, especially in the field of biomedical imaging, acquiring optically sectioned images from deep inside the tissue is very important. As well know already, confocal laser scanning microscopy (the most well-known optical sectioning microscopy gives axially-resolved fluorescence information using the physical background blocking component called pinhole. However, the axial range of imaging is practically limited due to such optical phenomena as the light scattered and absorbed in the tissue. However, nonlinear optical microscopy (e.g. Multiphoton microscopy, harmonic generation microscopy, coherent anti-Stokes Raman spectroscopy realized by the development of ultrafast light sources has been used for visualizing various tissues, especially in vivo, because of their low sensitivity to the limitation caused by the scattering and the absorption of light. Although nonlinear optical microscopy gives deep tissue image, it is not easy for many researcher to build customized nonlinear system. Here, we introduce an easy and simple way designing and developing such nonlinear optical microscope with upright or inverted epi-illumination platform using commercial optical components only.

  20. Impact of 4-epi-oxytetracycline on the gut microbiota and blood metabolomics of Wistar rats.

    Science.gov (United States)

    Han, Hongxing; Xiao, Hailong; Zhang, Kai; Lu, Zhenmei

    2016-03-15

    The impact of 4-epi-oxytetracycline (4-EOTC), one of the main oxytetracycline (OTC) metabolites, on the gut microbiota and physiological metabolism of Wistar rats was analyzed to explore the dynamic alterations apparent after repeated oral exposure (0.5, 5.0 or 50.0 mg/kg bw) for 15 days as shown by 16S rRNA pyrosequencing and UPLC-Q-TOF/MS analysis. Both principal component analysis and cluster analysis showed consistently altered patterns with distinct differences in the treated groups versus the control groups. 4-EOTC treatment at 5.0 or 50.0 mg/kg increased the relative abundance of the Actinobacteria, specifically Bifidobacteriaceae, and improved the synthesis of lysophosphatidylcholine (LysoPC), as shown by the lipid biomarkers LysoPC(16:0), LysoPC(18:3), LysoPC(20:3), and LysoPC(20:4). The metabolomic analysis of urine samples also identified four other decreased metabolites: diacylglycerol, sphingomyelin, triacylglycerol, and phosphatidylglycerol. Notably, the significant changes observed in these biomarkers demonstrated the ongoing disorder induced by 4-EOTC. Blood and urine analysis revealed that residual 4-EOTC accumulated in the rats, even two weeks after oral 4-EOTC administration, ceased. Thus, through thorough analysis, it can be concluded that the alteration of the gut microbiota and disorders in blood metabolomics are correlated with 4-EOTC treatment.

  1. Os Episódios de Rita Patrício

    Directory of Open Access Journals (Sweden)

    Gustavo Rubim

    2014-12-01

    O texto propõe uma leitura do livro Episódios: da teorização estética em Fernando Pessoa, da au­toria de Rita Patrício. Datado de 2012, o livro só ficou realmente pronto e publicado em 2014. A leitura de­fende a originalidade deste exame minucioso dos textos de teoria estética e literária de Fernando Pessoa, tanto pela maneira como os trata autonomamente da obra poética e os estuda na sua escrita específica, quanto pelo efeito de deslocação dos tópicos habituais na análise do programa modernista português. A crí­tica do idealismo pessoano e da noção de obra enquanto totalidade or­gânica são sublinhados enquanto gestos condutores de toda a pesquisa. Propõem-se articulações com outros ensaios recentes que em Portugal procedem à revisão da crítica e da hermenêutica pes­soana.

  2. Measurement of anatomy contouring in EPI review: a practical method for use in radiation therapy departments

    International Nuclear Information System (INIS)

    Halkett, Georgia; Williams, Marie

    2004-01-01

    Radiation therapy treatment verification can be performed using hard copy portal films or digital Electronic Portal Images (EPI) of the treatment field, acquired at the time of treatment. This paper describes a practical method of assessing the accuracy of reference anatomy outlining, for treatment sites involving the pelvis, breast and lumbar spine. Seven original bone anatomy outlines contoured onto verification images of five patients, were printed on transparency sheets and reference points were marked at equal distances along the anatomy curves. Two sample anatomy contour sets were created by two independent radiation therapists who outlined visible bone anatomy on the same seven digitally reconstructed radiographs (DRR) and hard copy outlines were obtained. Three independent observers with differing levels of experience, assessed the discrepancies between the original anatomy contours and the sample sets on two occasions one week apart, by measuring the distances between the original and sample set contours (absolute values in mm). The degree of agreement between the same assessor on two occasions (intra-rater reliability) and between assessors (inter-rater reliability) was analysed using parametric analysis for levels of relationship and significant differences. This simple method of reference anatomy outline measurement was shown to be highly reliable within assessors and between assessors (r > 0.87 and rz > 0.75 for both intra- and inter-rater comparisons). This measurement process may be a suitable method, for undertaking quality assurance activities in image verification within radiation therapy departments. Copyright (2004) Australian Institute of Radiography

  3. Views on Software Testability

    OpenAIRE

    Shimeall, Timothy; Friedman, Michael; Chilenski, John; Voas, Jeffrey

    1994-01-01

    The field of testability is an active, well-established part of engineering of modern computer systems. However, only recently have technologies for software testability began to be developed. These technologies focus on accessing the aspects of software that improve or depreciate the ease of testing. As both the size of implemented software and the amount of effort required to test that software increase, so will the important of software testability technologies in influencing the softwa...

  4. Agile software assessment

    OpenAIRE

    Nierstrasz Oscar; Lungu Mircea

    2012-01-01

    Informed decision making is a critical activity in software development but it is poorly supported by common development environments which focus mainly on low level programming tasks. We posit the need for agile software assessment which aims to support decision making by enabling rapid and effective construction of software models and custom analyses. Agile software assessment entails gathering and exploiting the broader context of software information related to the system at hand as well ...

  5. Software component quality evaluation

    Science.gov (United States)

    Clough, A. J.

    1991-01-01

    The paper describes a software inspection process that can be used to evaluate the quality of software components. Quality criteria, process application, independent testing of the process and proposed associated tool support are covered. Early results indicate that this technique is well suited for assessing software component quality in a standardized fashion. With automated machine assistance to facilitate both the evaluation and selection of software components, such a technique should promote effective reuse of software components.

  6. 2018-04-21T19:46:15Z https://www.ajol.info/index.php/index/oai oai ...

    African Journals Online (AJOL)

    Cannabis was the most abused drug in 2002-2007 (53.5%) as compared to cocaine (44%) in 1992–1997 (c2 35.5, p West African College of Physicians and the West African College of Surgeons 2010-06-29 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf ...

  7. ViralEpi v1.0: a high-throughput spectrum of viral epigenomic methylation profiles from diverse diseases.

    Science.gov (United States)

    Khan, Mohd Shoaib; Gupta, Amit Kumar; Kumar, Manoj

    2016-01-01

    To develop a computational resource for viral epigenomic methylation profiles from diverse diseases. Methylation patterns of Epstein-Barr virus and hepatitis B virus genomic regions are provided as web platform developed using open source Linux-Apache-MySQL-PHP (LAMP) bundle: programming and scripting languages, that is, HTML, JavaScript and PERL. A comprehensive and integrated web resource ViralEpi v1.0 is developed providing well-organized compendium of methylation events and statistical analysis associated with several diseases. Additionally, it also facilitates 'Viral EpiGenome Browser' for user-affable browsing experience using JavaScript-based JBrowse. This web resource would be helpful for research community engaged in studying epigenetic biomarkers for appropriate prognosis and diagnosis of diseases and its various stages.

  8. Software Quality Assurance Metrics

    Science.gov (United States)

    McRae, Kalindra A.

    2004-01-01

    Software Quality Assurance (SQA) is a planned and systematic set of activities that ensures conformance of software life cycle processes and products conform to requirements, standards and procedures. In software development, software quality means meeting requirements and a degree of excellence and refinement of a project or product. Software Quality is a set of attributes of a software product by which its quality is described and evaluated. The set of attributes includes functionality, reliability, usability, efficiency, maintainability, and portability. Software Metrics help us understand the technical process that is used to develop a product. The process is measured to improve it and the product is measured to increase quality throughout the life cycle of software. Software Metrics are measurements of the quality of software. Software is measured to indicate the quality of the product, to assess the productivity of the people who produce the product, to assess the benefits derived from new software engineering methods and tools, to form a baseline for estimation, and to help justify requests for new tools or additional training. Any part of the software development can be measured. If Software Metrics are implemented in software development, it can save time, money, and allow the organization to identify the caused of defects which have the greatest effect on software development. The summer of 2004, I worked with Cynthia Calhoun and Frank Robinson in the Software Assurance/Risk Management department. My task was to research and collect, compile, and analyze SQA Metrics that have been used in other projects that are not currently being used by the SA team and report them to the Software Assurance team to see if any metrics can be implemented in their software assurance life cycle process.

  9. Software Engineering Program: Software Process Improvement Guidebook

    Science.gov (United States)

    1996-01-01

    The purpose of this document is to provide experience-based guidance in implementing a software process improvement program in any NASA software development or maintenance community. This guidebook details how to define, operate, and implement a working software process improvement program. It describes the concept of the software process improvement program and its basic organizational components. It then describes the structure, organization, and operation of the software process improvement program, illustrating all these concepts with specific NASA examples. The information presented in the document is derived from the experiences of several NASA software organizations, including the SEL, the SEAL, and the SORCE. Their experiences reflect many of the elements of software process improvement within NASA. This guidebook presents lessons learned in a form usable by anyone considering establishing a software process improvement program within his or her own environment. This guidebook attempts to balance general and detailed information. It provides material general enough to be usable by NASA organizations whose characteristics do not directly match those of the sources of the information and models presented herein. It also keeps the ideas sufficiently close to the sources of the practical experiences that have generated the models and information.

  10. From Software Development to Software Assembly

    NARCIS (Netherlands)

    Sneed, Harry M.; Verhoef, Chris

    2016-01-01

    The lack of skilled programming personnel and the growing burden of maintaining customized software are forcing organizations to quit producing their own software. It's high time they turned to ready-made, standard components to fulfill their business requirements. Cloud services might be one way to

  11. 7-epi-griffonilide, a new lactone from Bauhinia pentandra: complete 1H and 13C chemical shift assignments.

    Science.gov (United States)

    Almeida, Macia C S DE; Souza, Luciana G S; Ferreira, Daniele A; Pinto, Francisco C L; Oliveira, Débora R DE; Santiago, Gilvandete M P; Monte, Francisco J Q; Braz-Filho, Raimundo; Lemos, Telma L G DE

    2017-01-01

    A new lactone, 7-epi-griffonilide (1), and six known compounds, 2, 3a - 3c, 4a and 4b, were isolated from the leaves of Bauhinia pentandra (Fabaceae). The structures elucidation of 1 and 2 were based on detailed 2D NMR techniques and spectral comparison with related compounds, leading to complete assignment of the 1H and 13C NMR spectra.

  12. Total dose and dose rate radiation characterization of EPI-CMOS radiation hardened memory and microprocessor devices

    International Nuclear Information System (INIS)

    Gingerich, B.L.; Hermsen, J.M.; Lee, J.C.; Schroeder, J.E.

    1984-01-01

    The process, circuit discription, and total dose radiation characteristics are presented for two second generation hardened 4K EPI-CMOS RAMs and a first generation 80C85 microprocessor. Total dose radiation performance is presented to 10M rad-Si and effects of biasing and operating conditions are discussed. The dose rate sensitivity of the 4K RAMs is also presented along with single event upset (SEU) test data

  13. Isolation of campesteryl ferulate and epi-campesteryl ferulate, two components of γ-oryzanol from rice bran.

    Science.gov (United States)

    Bao, Yuhua; Yanase, Emiko; Nakatsuka, Shin-ichi

    2013-01-01

    Campesteryl ferulate (3a, 24R/α) and epi-campesteryl ferulate (3b, 24S/β), components of rice bran γ-oryzanol, were isolated by the preparative recycle HPLC system using a combination of ODS silica and cholester packed columns at over 99% purity. Their purities and structures of 3a and 3b thus obtained were confirmed by HPLC analysis and physical data (1H- and 13C-NMR, MS spectra, and X-ray crystallography).

  14. Concurrent correction of geometric distortion and motion using the map-slice-to-volume method in EPI

    Science.gov (United States)

    Yeo, Desmond T. B.; Fessler, Jeffrey A.; Kim, Boklye

    2014-01-01

    The accuracy of measuring voxel intensity changes between stimulus and rest images in fMRI echo-planar imaging (EPI) data is severely degraded in the presence of head motion. In addition, EPI is sensitive to susceptibility-induced geometric distortions. Head motion causes image shifts and associated field map changes that induce different geometric distortion at different time points. Conventionally, geometric distortion is “corrected” with a static field map independently of image registration. That approach ignores all field map changes induced by head motion. This work evaluates the improved motion correction capability of mapping slice to volume (MSV) registration with concurrent iterative field corrected reconstruction using updated field maps derived from an initial static field map that has been spatially transformed and resampled. It accounts for motion-induced field map changes for translational and in-plane rotation motion. The results from simulated EPI time series data, in which motion, image intensity and activation ground truths are available, show improved accuracy in image registration, field corrected image reconstruction and activation detection. PMID:18280077

  15. EpiGeNet: A Graph Database of Interdependencies Between Genetic and Epigenetic Events in Colorectal Cancer.

    Science.gov (United States)

    Balaur, Irina; Saqi, Mansoor; Barat, Ana; Lysenko, Artem; Mazein, Alexander; Rawlings, Christopher J; Ruskin, Heather J; Auffray, Charles

    2017-10-01

    The development of colorectal cancer (CRC)-the third most common cancer type-has been associated with deregulations of cellular mechanisms stimulated by both genetic and epigenetic events. StatEpigen is a manually curated and annotated database, containing information on interdependencies between genetic and epigenetic signals, and specialized currently for CRC research. Although StatEpigen provides a well-developed graphical user interface for information retrieval, advanced queries involving associations between multiple concepts can benefit from more detailed graph representation of the integrated data. This can be achieved by using a graph database (NoSQL) approach. Data were extracted from StatEpigen and imported to our newly developed EpiGeNet, a graph database for storage and querying of conditional relationships between molecular (genetic and epigenetic) events observed at different stages of colorectal oncogenesis. We illustrate the enhanced capability of EpiGeNet for exploration of different queries related to colorectal tumor progression; specifically, we demonstrate the query process for (i) stage-specific molecular events, (ii) most frequently observed genetic and epigenetic interdependencies in colon adenoma, and (iii) paths connecting key genes reported in CRC and associated events. The EpiGeNet framework offers improved capability for management and visualization of data on molecular events specific to CRC initiation and progression.

  16. Low Defect Density Substrates and High-Quality Epi-Substrate Interfaces for ABCS Devices and Progress Toward Phonon-Mediated THz Lasers

    National Research Council Canada - National Science Library

    Goodhue, William; Bliss, David; Krishnaswami, Kannan; Vangala, Shivashankar; Li, Jin; Zhu, Beihong

    2005-01-01

    ... has been developing technology for producing low defect density substrates and high-quality epi-substrate interfaces for ABCS device applications as well as developing fabrication and device concepts...

  17. Total synthesis of a CD-ring: side-chain building block for preparing 17-epi-calcitriol derivatives from the Hajos-Parrish dione.

    Science.gov (United States)

    Michalak, Karol; Wicha, Jerzy

    2011-08-19

    An efficient synthesis of the key building block for 17-epi-calctriol from the Hajos-Parrish dione involving a sequence of diastereoselective transformation of the azulene core and the side-chain construction is presented.

  18. EGF–FGF{sub 2} stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)

    Energy Technology Data Exchange (ETDEWEB)

    Bressan, Raul Bardini; Melo, Fernanda Rosene; Almeida, Patricia Alves; Bittencourt, Denise Avani; Visoni, Silvia; Jeremias, Talita Silva [Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil); Costa, Ana Paula; Leal, Rodrigo Bainy [Departamento de Bioquímica, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil); Trentin, Andrea Gonçalves, E-mail: andrea.trentin@ufsc.br [Departamento de Biologia Celular, Embriologia e Genética, Centro de Ciências Biológicas, Universidade Federal de Santa Catarina, Campus Universitário – Trindade, 88040-900 Florianópolis SC (Brazil)

    2014-09-10

    Epidermal neural crest stem cells (EPI-NCSCs), which reside in the bulge of hair follicles, are attractive candidates for several applications in cell therapy, drug screening and tissue engineering. As suggested remnants of the embryonic neural crest (NC) in an adult location, EPI-NCSCs are able to generate a wide variety of cell types and are readily accessible by a minimally invasive procedure. Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF{sub 2}) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the proliferation and neuronal potential of mouse EPI-NCSCs. By using a recognized culture protocol of bulge whiskers follicles, we were able to isolate a population of EPI-NCSCs, characterized by the migratory potential, cell morphology and expression of phenotypic markers of NC cells. EPI-NCSCs expressed neuronal, glial and smooth muscle markers and exhibited the NC-like fibroblastic morphology. The treatment with the combination EGF and FGF{sub 2}, however, increased their proliferation rate and promoted the acquisition of a neuronal-like morphology accompanied by reorganization of neural cytoskeletal proteins βIII-tubulin and nestin, as well as upregulation of the pan neuronal marker βIII-tubulin and down regulation of the undifferentiated NC, glial and smooth muscle cell markers. Moreover, the treatment enhanced the response of EPI-NCSCs to neurogenic stimulation, as evidenced by induction of GAP43, and increased expression of Mash-1 in neuron-like cell, both neuronal-specific proteins. Together, the results suggest that the combination of EGF–FGF2 stimulates the proliferation and improves the neuronal potential of EPI-NCSCs similarly to embryonic NC cells, ES cells and neural progenitor/stem cells of the central nervous system and highlights the advantage of using EGF–FGF{sub 2} in neuronal differentiation protocols. - Highlights: • EPI

  19. EGF–FGF2 stimulates the proliferation and improves the neuronal commitment of mouse epidermal neural crest stem cells (EPI-NCSCs)

    International Nuclear Information System (INIS)

    Bressan, Raul Bardini; Melo, Fernanda Rosene; Almeida, Patricia Alves; Bittencourt, Denise Avani; Visoni, Silvia; Jeremias, Talita Silva; Costa, Ana Paula; Leal, Rodrigo Bainy; Trentin, Andrea Gonçalves

    2014-01-01

    Epidermal neural crest stem cells (EPI-NCSCs), which reside in the bulge of hair follicles, are attractive candidates for several applications in cell therapy, drug screening and tissue engineering. As suggested remnants of the embryonic neural crest (NC) in an adult location, EPI-NCSCs are able to generate a wide variety of cell types and are readily accessible by a minimally invasive procedure. Since the combination of epidermal growth factor (EGF) and fibroblast growth factor type 2 (FGF 2 ) is mitogenic and promotes the neuronal commitment of various stem cell populations, we examined its effects in the proliferation and neuronal potential of mouse EPI-NCSCs. By using a recognized culture protocol of bulge whiskers follicles, we were able to isolate a population of EPI-NCSCs, characterized by the migratory potential, cell morphology and expression of phenotypic markers of NC cells. EPI-NCSCs expressed neuronal, glial and smooth muscle markers and exhibited the NC-like fibroblastic morphology. The treatment with the combination EGF and FGF 2 , however, increased their proliferation rate and promoted the acquisition of a neuronal-like morphology accompanied by reorganization of neural cytoskeletal proteins βIII-tubulin and nestin, as well as upregulation of the pan neuronal marker βIII-tubulin and down regulation of the undifferentiated NC, glial and smooth muscle cell markers. Moreover, the treatment enhanced the response of EPI-NCSCs to neurogenic stimulation, as evidenced by induction of GAP43, and increased expression of Mash-1 in neuron-like cell, both neuronal-specific proteins. Together, the results suggest that the combination of EGF–FGF2 stimulates the proliferation and improves the neuronal potential of EPI-NCSCs similarly to embryonic NC cells, ES cells and neural progenitor/stem cells of the central nervous system and highlights the advantage of using EGF–FGF 2 in neuronal differentiation protocols. - Highlights: • EPI-NCSCs express

  20. Service for victims of crime VDS info and victims’ support: Analysis of the previous work

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja M.

    2004-01-01

    Full Text Available The first victim support service in our country VDS info and victims’ support started with its work in April 2003 within the Victimology Society of Serbia. This service is aimed at victims of crime (women and men, primarily at victims of violent crime, but also of some forms of property crime (such as burglary. The aim of the Service is to offer victims of crime information on their rights and the ways of how to realize them, emotional support, as well as to refer them to other institutions/organizations depending on the certain victim’s needs. Coordinators and volunteers, who passed the appropriate training, are responsible for that. Bearing that in mind, this paper will give the brief glens on the Service itself, its organization and the way of work, followed by the analysis of the results of previous work.

  1. Design and Development of ChemInfoCloud: An Integrated Cloud Enabled Platform for Virtual Screening.

    Science.gov (United States)

    Karthikeyan, Muthukumarasamy; Pandit, Deepak; Bhavasar, Arvind; Vyas, Renu

    2015-01-01

    The power of cloud computing and distributed computing has been harnessed to handle vast and heterogeneous data required to be processed in any virtual screening protocol. A cloud computing platorm ChemInfoCloud was built and integrated with several chemoinformatics and bioinformatics tools. The robust engine performs the core chemoinformatics tasks of lead generation, lead optimisation and property prediction in a fast and efficient manner. It has also been provided with some of the bioinformatics functionalities including sequence alignment, active site pose prediction and protein ligand docking. Text mining, NMR chemical shift (1H, 13C) prediction and reaction fingerprint generation modules for efficient lead discovery are also implemented in this platform. We have developed an integrated problem solving cloud environment for virtual screening studies that also provides workflow management, better usability and interaction with end users using container based virtualization, OpenVz.

  2. www.kerntechnik.info = annual meeting on nuclear technology on the web

    International Nuclear Information System (INIS)

    Anon.

    2009-01-01

    The ANNUAL MEETING ON NUCLEAR TECHNOLOGY can be found under the new Internet address of www.kerntechnik.info as of now. The Web site offers systematic access to all important information and features about this largest European specialized meeting of its kind. Pages showing the program of the Conference with its plenary session, topical sessions, technical sessions, and the ''Nuclear Power Campus'' and ''Competency Workshop'' special events, are updated continuously. In addition, contributions to the technical sessions may be submitted on line at an early point in time; registrating for the meeting as well as booking hotel accommodation are also possible on line. The next ANNUAL MEETING ON NUCLEAR TECHNOLOGY will be held at the Berlin Congress Center in Berlin/Germany on May 4-6, 2010. (orig.)

  3. Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe An EpiCom study

    DEFF Research Database (Denmark)

    Burisch, Johan Michael; Cukovic-Cavka, Silvija; Kaimakliotis, Ioannis

    2011-01-01

    The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration.......The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration....

  4. Estimation of the glomerular filtration rate in people older than 85: Comparisons between CKD-EPI, MDRD-IDMS and BIS1 equations

    Directory of Open Access Journals (Sweden)

    Fernando Bustos-Guadaño

    2017-03-01

    Conclusions: The GFR estimations obtained with BS1 equation are not interchangeable with MDRD-IDMS or CKD-EPI equations. BIS1 estimates lower GFR values than MDRD-IDMS and CKD-EPI and tends to classify the patients in a more advanced chronic kidney disease stage, especially for estimated GFR higher than 29 mL/min/1.73 m2.

  5. PHYSICAL MODELLING OF TERRAIN DIRECTLY FROM SURFER GRID AND ARC/INFO ASCII DATA FORMATS#

    Directory of Open Access Journals (Sweden)

    Y.K. Modi

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: Additive manufacturing technology is used to make physical models of terrain using GIS surface data. Attempts have been made to understand several other GIS file formats, such as the Surfer grid and the ARC/INFO ASCII grid. The surface of the terrain in these file formats has been converted into an STL file format that is suitable for additive manufacturing. The STL surface is converted into a 3D model by making the walls and the base. In this paper, the terrain modelling work has been extended to several other widely-used GIS file formats. Terrain models can be created in less time and at less cost, and intricate geometries of terrain can be created with ease and great accuracy.

    AFRIKAANSE OPSOMMING: Laagvervaardigingstegnologie word gebruik om fisiese modelle van terreine vanaf GIS oppervlakdata te maak. Daar is gepoog om verskeie ander GIS lêerformate, soos die Surfer rooster en die ARC/INFO ASCII rooster, te verstaan. Die oppervlak van die terrein in hierdie lêerformate is omgeskakel in 'n STL lêerformaat wat geskik is vir laagvervaardiging. Verder is die STL oppervlak omgeskakel in 'n 3D model deur die kante en die basis te modelleer. In hierdie artikel is die terreinmodelleringswerk uitgebrei na verskeie ander algemeen gebruikte GIS lêerformate. Terreinmodelle kan so geskep word in korter tyd en teen laer koste, terwyl komplekse geometrieë van terreine met gemak en groot akkuraatheid geskep kan word.

  6. A critical review of the readability of online patient education resources from RadiologyInfo.Org.

    Science.gov (United States)

    Hansberry, David R; John, Ann; John, Elizabeth; Agarwal, Nitin; Gonzales, Sharon F; Baker, Stephen R

    2014-03-01

    Health consumers and their families rely on the Internet as a source of authoritative information regarding the procedures used to reach a diagnosis, effect treatment, and influence prognosis. In radiology, online materials can be a means by which to offer patients comprehensible explanations of the capabilities, the risks and rewards, and the techniques under our purview. Consequently, estimations of health literacy should take into account the reading level of the average American when composing and transmitting such information to the lay public without the mediation of a referring physician. In December 2012, patient education reports from the files of RadiologyInfo.org, a jointly sponsored website of the American College of Radiology and the Radiological Society of North America, were downloaded to assess their textual sophistication. All 138 patient education articles including the glossary were analyzed for their respective level of "readability" using the following 10 evaluative scales: Flesch Reading Ease, Flesch-Kincaid Grade Level, Simple Measure of Gobbledygook Grading, Coleman-Liau Index, Gunning Fog Index, New Dale-Chall scale, FORCAST, Fry graph, Raygor Readability Estimate, and New Fog Count. The 138 online patient education articles were written, on average, between the 10th and 14th grade levels, which exceeds both the American Medical Association and the National Institutes of Health recommendations that patient education resources be comprehensible to those who read no higher than the seventh grade level. Patients may accrue a greater benefit from written articles available on RadiologyInfo.org if the texts were revised to be in compliance with the National Institutes of Health and American Medical Association grade level recommendations. This could lead to a broadened appreciation of the capabilities of radiology's role in general and enhanced understanding of imaging techniques and their application to clinical practice.

  7. Software Engineering Improvement Plan

    Science.gov (United States)

    2006-01-01

    In performance of this task order, bd Systems personnel provided support to the Flight Software Branch and the Software Working Group through multiple tasks related to software engineering improvement and to activities of the independent Technical Authority (iTA) Discipline Technical Warrant Holder (DTWH) for software engineering. To ensure that the products, comments, and recommendations complied with customer requirements and the statement of work, bd Systems personnel maintained close coordination with the customer. These personnel performed work in areas such as update of agency requirements and directives database, software effort estimation, software problem reports, a web-based process asset library, miscellaneous documentation review, software system requirements, issue tracking software survey, systems engineering NPR, and project-related reviews. This report contains a summary of the work performed and the accomplishments in each of these areas.

  8. Spotting software errors sooner

    International Nuclear Information System (INIS)

    Munro, D.

    1989-01-01

    Static analysis is helping to identify software errors at an earlier stage and more cheaply than conventional methods of testing. RTP Software's MALPAS system also has the ability to check that a code conforms to its original specification. (author)

  9. Avionics and Software Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The goal of the AES Avionics and Software (A&S) project is to develop a reference avionics and software architecture that is based on standards and that can be...

  10. Paladin Software Support Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The Paladin Software Support Environment (SSE) occupies 2,241 square-feet. It contains the hardware and software tools required to support the Paladin Automatic Fire...

  11. Pragmatic Software Innovation

    DEFF Research Database (Denmark)

    Aaen, Ivan; Jensen, Rikke Hagensby

    2014-01-01

    We understand software innovation as concerned with introducing innovation into the development of software intensive systems, i.e. systems in which software development and/or integration are dominant considerations. Innovation is key in almost any strategy for competitiveness in existing markets......, for creating new markets, or for curbing rising public expenses, and software intensive systems are core elements in most such strategies. Software innovation therefore is vital for about every sector of the economy. Changes in software technologies over the last decades have opened up for experimentation......, learning, and flexibility in ongoing software projects, but how can this change be used to facilitate software innovation? How can a team systematically identify and pursue opportunities to create added value in ongoing projects? In this paper, we describe Deweyan pragmatism as the philosophical foundation...

  12. Process mining software repositories

    NARCIS (Netherlands)

    Poncin, W.; Serebrenik, A.; Brand, van den M.G.J.

    2011-01-01

    Software developers' activities are in general recorded in software repositories such as version control systems, bug trackers and mail archives. While abundant information is usually present in such repositories, successful information extraction is often challenged by the necessity to

  13. Clinical evaluation of echo-planar diffusion-weighted imaging (EPI-DWI) for diagnosis of breast cancer

    International Nuclear Information System (INIS)

    Nakajima, Mika; Nitatori, Toshiaki; Matsuda, Minoru; Fukushima, Hisaki; Ihara, Kuniko; Seki, Tsuneaki

    2008-01-01

    The purpose of this study was to compare echo-planar diffusion-weighted imaging (EPI-DWI) with dynamic contrast-enhanced magnetic resonance imaging (MRI) in terms of the rate of detection, extension, and quality of diagnosis of breast cancer in order to estimate the usefulness of EPI-DWI. One hundred and three cases of 101 patients who underwent MRI prior to surgery for breast cancer were evaluated. (papillotubular carcinoma 22; solid-tubular carcinoma 20; scirrhous carcinoma 45; mucinous carcinoma 2; medullary carcinoma 1; invasive lobular carcinoma 2; apocrine carcinoma 2; ductal carcinoma in situ (DCIS) and microinvasive ductal carcinoma 9). Twelve cases of benign lesion were also evaluated. Single-shot EPI-DWI was performed before routine dynamic MRI and images of cancer detection and cancer extension both were compared with the pathological findings. The apparent diffusion coefficient (ADC) values of the lesions were measured and compared to the ADC values of benign lesions and normal breast tissues. The differences between the ADC values for the various histopathological types and the time-intensity curve (TIC) patterns of the dynamic MRI were also estimated. The EPI-DWI demonstrated abnormal high-intensity areas corresponding to the breast cancer lesions; these areas demonstrated good correlation with the enhanced areas observed in the early phase of dynamic MRI and cancer extension in the pathological findings. Frequently, normal breast tissues manifested as high-intensity areas in EPI-DWI; however, it was possible to distinguish between normal breast tissues and breast lesions by correlating these images with T2- weighted images and corresponding ADC values. The threshold value between malignant and benign lesions that resulted both high sensitivity and specificity was about 1.5 x 10 -3 x mm 2 /second. Mucinous carcinoma and DCIS/ microinvasive carcinoma exhibited higher ADC values than those observed in the other histopathological types, however, no

  14. Optimization of Antivirus Software

    OpenAIRE

    Catalin BOJA; Adrian VISOIU

    2007-01-01

    The paper describes the main techniques used in development of computer antivirus software applications. For this particular category of software, are identified and defined optimum criteria that helps determine which solution is better and what are the objectives of the optimization process. From the general viewpoint of software optimization are presented methods and techniques that are applied at code development level. Regarding the particularities of antivirus software, the paper analyze...

  15. Gammasphere software development

    International Nuclear Information System (INIS)

    Piercey, R.B.

    1994-01-01

    This report describes the activities of the nuclear physics group at Mississippi State University which were performed during 1993. Significant progress has been made in the focus areas: chairing the Gammasphere Software Working Group (SWG); assisting with the porting and enhancement of the ORNL UPAK histogramming software package; and developing standard formats for Gammasphere data products. In addition, they have established a new public ftp archive to distribute software and software development tools and information

  16. Software engineer's pocket book

    CERN Document Server

    Tooley, Michael

    2013-01-01

    Software Engineer's Pocket Book provides a concise discussion on various aspects of software engineering. The book is comprised of six chapters that tackle various areas of concerns in software engineering. Chapter 1 discusses software development, and Chapter 2 covers programming languages. Chapter 3 deals with operating systems. The book also tackles discrete mathematics and numerical computation. Data structures and algorithms are also explained. The text will be of great use to individuals involved in the specification, design, development, implementation, testing, maintenance, and qualit

  17. Software Testing Requires Variability

    DEFF Research Database (Denmark)

    Christensen, Henrik Bærbak

    2003-01-01

    Software variability is the ability of a software system or artefact to be changed, customized or configured for use in a particular context. Variability in software systems is important from a number of perspectives. Some perspectives rightly receive much attention due to their direct economic...... impact in software production. As is also apparent from the call for papers these perspectives focus on qualities such as reuse, adaptability, and maintainability....

  18. Live or Let Die: Epithelial Flap Vitality and Keratocyte Proliferation Following LASEK and Epi-LASIK in Human Donor and Porcine Eyes.

    Science.gov (United States)

    Angunawela, Romesh I; Winkler von Mohrenfels, Christoph; Kumar, Anupma; O'Brart, David P S; Marshall, John

    2011-02-01

    To determine the relationship between epithelial flap vitality and stromal keratocyte proliferation following two epithelial refractive techniques: epi-LASIK and laser epithelial keratomileusis (LASEK). Human corneas were maintained in organ culture and underwent standard -6.00-diopter ablation. Rates of stromal keratocyte proliferation were detected 1 week postoperative using a Ki67 antibody specific to proliferating cells. Images were captured with a laser scanning confocal microscope and analyzed by a masked observer. Epithelial flap vitality was determined with propidium iodide using fresh porcine corneas. Epithelial flaps were created with Gebauer Epikeratome epi-LASIK or alcohol-assisted LASEK method. Flaps treated with 100% alcohol and uninjured corneas were used as controls. The number of proliferating keratocytes was greatest at 1 week in the epi-LASIK corneas (Pvitality was greatest in the epi-LASIK flaps and declined in the LASEK and 100% alcohol flaps (Plive cells. There is also a greater number of proliferating stromal cells following epi-LASIK at 1 week. Based on these in vitro observations, epi-LASIK may result in greater levels of haze compared to LASEK. Copyright 2011, SLACK Incorporated.

  19. PRK vs LASEK vs Epi-LASIK: a comparison of corneal haze, postoperative pain and visual recovery in moderate to high myopia.

    Science.gov (United States)

    Reilly, C D; Panday, V; Lazos, V; Mittelstaedt, B R

    2010-01-01

    The field of refractive surgery continues to evolve amid continued concerns as to which surgical technique minimizes the risk of inducing ectasia. To compare clinical outcomes between PRK, LASEK and Epi-LASIK in moderately to highly myopic eyes (-4.00 D to -8.00 D). A retrospective chart review of 100 PRK eyes, 100 LASEK eyes (with alcohol) and 97 Epi-LASIK eyes was performed. Post-operative pain, uncorrected visual acuity, and corneal haze data was recorded and analyzed at post-op days 1, 4 and 7 and at post-op months 1, 3, 6 and 12. In all groups surgical corrections ranged from -4.00 D to -8.00 D. There was less pain associated with the epi-LASIK procedure especially early (post-op days 1 and 4). Visual recovery was superior within the PRK group during the first post-operative week but by post-op week 4 all three were equal. Haze scores were similar but a trend for less haze was demonstrated with epi-LASIK at 6 and 12 months. Epi-LASIK has a slight advantage over PRK and LASEK early on in the post-op course with regards to pain. Visual recovery is similar by 4 weeks and is better with PRK early. In addition, epi-LASIK trends toward less significant haze. © Nepal Ophthalmic Society.

  20. Computer software quality assurance

    International Nuclear Information System (INIS)

    Ives, K.A.

    1986-06-01

    The author defines some criteria for the evaluation of software quality assurance elements for applicability to the regulation of the nuclear industry. The author then analyses a number of software quality assurance (SQA) standards. The major extracted SQA elements are then discussed, and finally specific software quality assurance recommendations are made for the nuclear industry

  1. Software Architecture Evolution

    Science.gov (United States)

    Barnes, Jeffrey M.

    2013-01-01

    Many software systems eventually undergo changes to their basic architectural structure. Such changes may be prompted by new feature requests, new quality attribute requirements, changing technology, or other reasons. Whatever the causes, architecture evolution is commonplace in real-world software projects. Today's software architects, however,…

  2. XES Software Communication Extension

    NARCIS (Netherlands)

    Leemans, M.; Liu, C.

    2017-01-01

    During the execution of software, execution data can be recorded. With the development of process mining techniques on the one hand, and the growing availability of software execution data on the other hand, a new form of software analytics comes into reach. That is, applying process mining

  3. Neutron Scattering Software

    Science.gov (United States)

    Home Page | Facilities | Reference | Software | Conferences | Announcements | Mailing Lists Neutron Scattering Banner Neutron Scattering Software A new portal for neutron scattering has just been established sets KUPLOT: data plotting and fitting software ILL/TAS: Matlab probrams for analyzing triple axis data

  4. XES Software Event Extension

    NARCIS (Netherlands)

    Leemans, M.; Liu, C.

    2017-01-01

    During the execution of software, execution data can be recorded. With the development of process mining techniques on the one hand, and the growing availability of software execution data on the other hand, a new form of software analytics comes into reach. That is, applying process mining

  5. ARC Software and Models

    Science.gov (United States)

    Archives RESEARCH ▼ Research Areas Ongoing Projects Completed Projects SOFTWARE CONTACT ▼ Primary Contacts Researchers External Link MLibrary Deep Blue Software Archive Most research conducted at the ARC produce software code and methodologies that are transferred to TARDEC and industry partners. These

  6. XES Software Telemetry Extension

    NARCIS (Netherlands)

    Leemans, M.; Liu, C.

    2017-01-01

    During the execution of software, execution data can be recorded. With the development of process mining techniques on the one hand, and the growing availability of software execution data on the other hand, a new form of software analytics comes into reach. That is, applying process mining

  7. Specifications in software prototyping

    OpenAIRE

    Luqi; Chang, Carl K.; Zhu, Hong

    1998-01-01

    We explore the use of software speci®cations for software prototyping. This paper describes a process model for software prototyping, and shows how specifications can be used to support such a process via a cellular mobile phone switch example.

  8. Software Engineering for Portability.

    Science.gov (United States)

    Stanchev, Ivan

    1990-01-01

    Discussion of the portability of educational software focuses on the software design and development process. Topics discussed include levels of portability; the user-computer dialog; software engineering principles; design techniques for student performance records; techniques of courseware programing; and suggestions for further research and…

  9. Software Acquisition and Software Engineering Best Practices

    National Research Council Canada - National Science Library

    Eslinger, S

    1999-01-01

    The purpose of this white paper is to address the issues raised in the recently published Senate Armed Services Committee Report 106-50 concerning Software Management Improvements for the Department of Defense (DoD...

  10. Software Quality Assurance in Software Projects: A Study of Pakistan

    OpenAIRE

    Faisal Shafique Butt; Sundus Shaukat; M. Wasif Nisar; Ehsan Ullah Munir; Muhammad Waseem; Kashif Ayyub

    2013-01-01

    Software quality is specific property which tells what kind of standard software should have. In a software project, quality is the key factor of success and decline of software related organization. Many researches have been done regarding software quality. Software related organization follows standards introduced by Capability Maturity Model Integration (CMMI) to achieve good quality software. Quality is divided into three main layers which are Software Quality Assurance (SQA), Software Qu...

  11. Licensing safety critical software

    International Nuclear Information System (INIS)

    Archinoff, G.H.; Brown, R.A.

    1990-01-01

    Licensing difficulties with the shutdown system software at the Darlington Nuclear Generating Station contributed to delays in starting up the station. Even though the station has now been given approval by the Atomic Energy Control Board (AECB) to operate, the software issue has not disappeared - Ontario Hydro has been instructed by the AECB to redesign the software. This article attempts to explain why software based shutdown systems were chosen for Darlington, why there was so much difficulty licensing them, and what the implications are for other safety related software based applications

  12. HAZARD ANALYSIS SOFTWARE

    International Nuclear Information System (INIS)

    Sommer, S; Tinh Tran, T.

    2008-01-01

    Washington Safety Management Solutions, LLC developed web-based software to improve the efficiency and consistency of hazard identification and analysis, control selection and classification, and to standardize analysis reporting at Savannah River Site. In the new nuclear age, information technology provides methods to improve the efficiency of the documented safety analysis development process which includes hazard analysis activities. This software provides a web interface that interacts with a relational database to support analysis, record data, and to ensure reporting consistency. A team of subject matter experts participated in a series of meetings to review the associated processes and procedures for requirements and standard practices. Through these meetings, a set of software requirements were developed and compiled into a requirements traceability matrix from which software could be developed. The software was tested to ensure compliance with the requirements. Training was provided to the hazard analysis leads. Hazard analysis teams using the software have verified its operability. The software has been classified as NQA-1, Level D, as it supports the analysis team but does not perform the analysis. The software can be transported to other sites with alternate risk schemes. The software is being used to support the development of 14 hazard analyses. User responses have been positive with a number of suggestions for improvement which are being incorporated as time permits. The software has enforced a uniform implementation of the site procedures. The software has significantly improved the efficiency and standardization of the hazard analysis process

  13. Software Validation in ATLAS

    International Nuclear Information System (INIS)

    Hodgkinson, Mark; Seuster, Rolf; Simmons, Brinick; Sherwood, Peter; Rousseau, David

    2012-01-01

    The ATLAS collaboration operates an extensive set of protocols to validate the quality of the offline software in a timely manner. This is essential in order to process the large amounts of data being collected by the ATLAS detector in 2011 without complications on the offline software side. We will discuss a number of different strategies used to validate the ATLAS offline software; running the ATLAS framework software, Athena, in a variety of configurations daily on each nightly build via the ATLAS Nightly System (ATN) and Run Time Tester (RTT) systems; the monitoring of these tests and checking the compilation of the software via distributed teams of rotating shifters; monitoring of and follow up on bug reports by the shifter teams and periodic software cleaning weeks to improve the quality of the offline software further.

  14. Residue depletion of oxytetracycline (OTC) and 4-epi-oxytetracycline (4-epi-OTC) in broiler chicken's claws by liquid chromatography-tandem mass spectrometry (LC-MS/MS).

    Science.gov (United States)

    Cornejo, J; Pokrant, E; Araya, D; Briceño, C; Hidalgo, H; Maddaleno, A; Araya-Jordán, C; San Martin, B

    2017-04-01

    Antibiotics are widely used in poultry production for the treatment of bacterial diseases. However, residues may remain in products and by-products destined for human consumption or animal feeding. The claws of chickens, which are a by-product of the poultry industry, can directly or indirectly enter the food chain as meals destined to feed other productive animals. Thus, it becomes necessary to determine and quantify antimicrobial residues present in this matrix. The objective of the study was to assess the depletion of oxytetracycline (OTC) and its metabolite 4-epi-OTC in broiler chicken's claws. Claws of 32 broilers treated with a therapeutic dosage of 10% OTC during 7 days were analysed. Samples were taken at days 3, 9, 15 and 19 post-treatment. As for the control group, eight broiler chickens were raised under the same conditions. Extraction was carried out through EDTA-McIlvaine buffer, and clean-up employed a SPE C-18 Sep-Pak®. Instrumental analysis was performed through LC-MS/MS. The concentrations of both analytes were determined in claw samples until day 19 post-treatment. Average concentrations were within the LOD (20 μg kg - 1 ) and LOQ (22 µg kg - 1 ) for OTC and 84 μg kg - 1 for 4-epi-OTC. Withdrawal times (WDTs) of 39 days for OTC and 54 days for 4-epi-OTC were established in claws based on 95% confidence. These findings demonstrate that claws can be a source of antimicrobial residue entry into the food chain, since the results showed that OTC and its metabolite can be found in chicken's claws for long periods, even exceeding the average lifespan of a broiler chicken.

  15. Factors associated with maintenance of the use of internet, EpiFloripa Idoso longitudinal study

    Directory of Open Access Journals (Sweden)

    Rodrigo de Rosso Krug

    2018-04-01

    Full Text Available ABSTRACT OBJECTIVE To describe the use of the internet and to identify the sociodemographic and health factors associated with changes in the use of the internet over four years in older adults participating in the Brazilian EpiFloripa Idoso study. METHODS This is a longitudinal home-based, population-based study with 1,197 older adults who live in the urban area of Florianópolis, State of Santa Catarina, Brazil. We applied a face-to-face interview. We describe the use of internet according to frequency, place, devices, and motives of the use of the internet. To identify factors associated with changes in the use of the internet, we categorized the outcome as: non-use of the internet, stopped using the internet, started using the internet, and kept using the internet. The independent variables were sex, age, family income, education level, family arrangement, marital status, presence of caregiver, paid work, and cognitive impairment screening. We used multinomial logistic regression with risk ratio (RR estimates and their respective confidence intervals (95%CI. RESULTS The prevalence of the use of internet increased from 22.9% in 2009–2010 to 26.6% in 2013–2014. Of the total number of older adults who participated in the study, 7.5% started using the internet, 3.2% stopped using it, 19.1% kept their use, and 70.2% kept their non-use in the analyzed period. Of the older adults who used the internet, most used it every day or almost every day of the week, in their own home, on desktop or portable computers, mainly to send and receive messages, to search for information to learn or investigate something, to find information about goods and services, and to use news, social networking, and health information websites. The factors associated with the use of internet over four years were: being male (RR = 2.19, 95%CI 1.48–3.26, higher monthly family income (RR = 3.53, 95%CI 1.35–9.23, higher education level (RR = 2.64, 95%CI 1.57–4.43, and

  16. Factors associated with maintenance of the use of internet, EpiFloripa Idoso longitudinal study.

    Science.gov (United States)

    Krug, Rodrigo de Rosso; Xavier, André Junqueira; d'Orsi, Eleonora

    2018-04-09

    To describe the use of the internet and to identify the sociodemographic and health factors associated with changes in the use of the internet over four years in older adults participating in the Brazilian EpiFloripa Idoso study. This is a longitudinal home-based, population-based study with 1,197 older adults who live in the urban area of Florianópolis, State of Santa Catarina, Brazil. We applied a face-to-face interview. We describe the use of internet according to frequency, place, devices, and motives of the use of the internet. To identify factors associated with changes in the use of the internet, we categorized the outcome as: non-use of the internet, stopped using the internet, started using the internet, and kept using the internet. The independent variables were sex, age, family income, education level, family arrangement, marital status, presence of caregiver, paid work, and cognitive impairment screening. We used multinomial logistic regression with risk ratio (RR) estimates and their respective confidence intervals (95%CI). The prevalence of the use of internet increased from 22.9% in 2009-2010 to 26.6% in 2013-2014. Of the total number of older adults who participated in the study, 7.5% started using the internet, 3.2% stopped using it, 19.1% kept their use, and 70.2% kept their non-use in the analyzed period. Of the older adults who used the internet, most used it every day or almost every day of the week, in their own home, on desktop or portable computers, mainly to send and receive messages, to search for information to learn or investigate something, to find information about goods and services, and to use news, social networking, and health information websites. The factors associated with the use of internet over four years were: being male (RR = 2.19, 95%CI 1.48-3.26), higher monthly family income (RR = 3.53, 95%CI 1.35-9.23), higher education level (RR = 2.64, 95%CI 1.57-4.43), and no presence of caregiver (RR = 0.08, 95%CI 0

  17. Fatores associados aos sintomas depressivos em idosos: estudo EpiFloripa

    Directory of Open Access Journals (Sweden)

    Lucelia Justino Borges

    2013-08-01

    Full Text Available OBJETIVO Analisar a prevalência e fatores associados a sintomas depressivos em idosos. MÉTODOS Estudo epidemiológico transversal e de base domiciliar (inquérito EpiFloripa Idoso com 1.656 idosos, realizado por conglomerados em dois estágios, setores censitários e domicílios, em Florianópolis, SC. A prevalência de sintomas depressivos (desfecho foi obtida por meio da Geriatric Depression Scale (GDS-15, e testadas associações segundo variáveis sociodemográficas, de saúde, comportamentais e sociais. Foram calculadas razões de prevalências brutas e ajustadas com intervalo de 95% de confiança por regressão de Poisson. RESULTADOS A prevalência de sintomas depressivos foi de 23,9% (IC95% 21,84;26,01. Os fatores de risco associados no modelo final foram: escolaridade de cinco a oito anos (RP = 1,50; IC95% 1,08; 2,08, um a quatro anos (RP = 1,62; IC95% 1,18; 2,23 e nenhum ano de estudo (RP = 2,11; IC95% 1,46;3,05; situação econômica pior quando comparada com a que tinha aos 50 anos (RP = 1,33; IC95% 1,02;1,74; déficit cognitivo (RP = 1,45; IC95% 1,21;1,75; percepção de saúde regular (RP = 1,95; IC95% 1,47;2,60 e ruim (RP = 2,64; IC95% 1,82;3,83; dependência funcional (RP = 1,83; IC95% 1,43; 2,33; e dor crônica (RP = 1,35; IC95% 1,10;1,67. Grupo etário de 70 a 79 anos (RP = 0,77; IC95% 0,64;0,93; atividade física de lazer (RP = 0,75; IC95% 0,59;0,94; participação em grupos de convivência ou religiosos (RP = 0,80; IC95% 0,64;0,99; e ter relação sexual (RP = 0,70; IC95% 0,53;0,94 mostraram-se fatores protetores ao aparecimento dos sintomas depressivos. CONCLUSÕES Situação clínica adversa, desvantagem socioeconômica e pouca atividade social e sexual mostraram-se associadas aos sintomas depressivos em idosos.

  18. NASA software documentation standard software engineering program

    Science.gov (United States)

    1991-01-01

    The NASA Software Documentation Standard (hereinafter referred to as Standard) can be applied to the documentation of all NASA software. This Standard is limited to documentation format and content requirements. It does not mandate specific management, engineering, or assurance standards or techniques. This Standard defines the format and content of documentation for software acquisition, development, and sustaining engineering. Format requirements address where information shall be recorded and content requirements address what information shall be recorded. This Standard provides a framework to allow consistency of documentation across NASA and visibility into the completeness of project documentation. This basic framework consists of four major sections (or volumes). The Management Plan contains all planning and business aspects of a software project, including engineering and assurance planning. The Product Specification contains all technical engineering information, including software requirements and design. The Assurance and Test Procedures contains all technical assurance information, including Test, Quality Assurance (QA), and Verification and Validation (V&V). The Management, Engineering, and Assurance Reports is the library and/or listing of all project reports.

  19. Science and Software

    Science.gov (United States)

    Zelt, C. A.

    2017-12-01

    Earth science attempts to understand how the earth works. This research often depends on software for modeling, processing, inverting or imaging. Freely sharing open-source software is essential to prevent reinventing the wheel and allows software to be improved and applied in ways the original author may never have envisioned. For young scientists, releasing software can increase their name ID when applying for jobs and funding, and create opportunities for collaborations when scientists who collect data want the software's creator to be involved in their project. However, we frequently hear scientists say software is a tool, it's not science. Creating software that implements a new or better way of earth modeling or geophysical processing, inverting or imaging should be viewed as earth science. Creating software for things like data visualization, format conversion, storage, or transmission, or programming to enhance computational performance, may be viewed as computer science. The former, ideally with an application to real data, can be published in earth science journals, the latter possibly in computer science journals. Citations in either case should accurately reflect the impact of the software on the community. Funding agencies need to support more software development and open-source releasing, and the community should give more high-profile awards for developing impactful open-source software. Funding support and community recognition for software development can have far reaching benefits when the software is used in foreseen and unforeseen ways, potentially for years after the original investment in the software development. For funding, an open-source release that is well documented should be required, with example input and output files. Appropriate funding will provide the incentive and time to release user-friendly software, and minimize the need for others to duplicate the effort. All funded software should be available through a single web site

  20. Software Maintenance and Evolution: The Implication for Software ...

    African Journals Online (AJOL)

    Software Maintenance and Evolution: The Implication for Software Development. ... Software maintenance is the process of modifying existing operational software by correcting errors, ... EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT

  1. [epiDRB--a new minimally invasive concept for referencing in the field of computer-assisted orthopaedic surgery].

    Science.gov (United States)

    Ohnsorge, J A K; Weisskopf, M; Siebert, C H

    2005-01-01

    Optoelectronic navigation for computer-assisted orthopaedic surgery (CAOS) is based on a firm connection of bone with passive reflectors or active light-emitting diodes in a specific three-dimensional pattern. Even a so-called "minimally-invasive" dynamic reference base (DRB) requires fixation with screws or clamps via incision of the skin. Consequently an originally percutaneous intervention would unnecessarily be extended to an open procedure. Thus, computer-assisted navigation is rarely applied. Due to their tree-like design most DRB's interfere with the surgeon's actions and therefore are at permanent risk to be accidentally dislocated. Accordingly, the optic communication between the camera and the operative site may repeatedly be interrupted. The aim of the research was the development of a less bulky, more comfortable, stable and safely trackable device that can be fixed truly percutaneously. With engineering support of the industrial partner the radiolucent epiDRB was developed. It can be fixed with two or more pins and gains additional stability from its epicutaneous position. The intraoperative applicability and reliability was experimentally tested. Its low centre of gravity and its flat design allow the device to be located directly in the area of interest. Thanks to its epicutaneous position and its particular shape the epiDRB may perpetually be tracked by the navigation system without hindering the surgeon's actions. Hence, the risk of being displaced by accident is minimised and the line of sight remains unaffected. With the newly developed epiDRB computer-assisted navigation becomes easier and safer to handle even in punctures and other percutaneous procedures at the spine as much as at the extremities without an unproportionate amount of additional trauma. Due to the special design referencing of more than one vertebral body is possible at one time, thus decreasing radiation exposure and increasing efficiency.

  2. Image Registration to Compensate for EPI Distortion in Patients with Brain Tumors: An Evaluation of Tract-Specific Effects.

    Science.gov (United States)

    Albi, Angela; Meola, Antonio; Zhang, Fan; Kahali, Pegah; Rigolo, Laura; Tax, Chantal M W; Ciris, Pelin Aksit; Essayed, Walid I; Unadkat, Prashin; Norton, Isaiah; Rathi, Yogesh; Olubiyi, Olutayo; Golby, Alexandra J; O'Donnell, Lauren J

    2018-03-01

    Diffusion magnetic resonance imaging (dMRI) provides preoperative maps of neurosurgical patients' white matter tracts, but these maps suffer from echo-planar imaging (EPI) distortions caused by magnetic field inhomogeneities. In clinical neurosurgical planning, these distortions are generally not corrected and thus contribute to the uncertainty of fiber tracking. Multiple image processing pipelines have been proposed for image-registration-based EPI distortion correction in healthy subjects. In this article, we perform the first comparison of such pipelines in neurosurgical patient data. Five pipelines were tested in a retrospective clinical dMRI dataset of 9 patients with brain tumors. Pipelines differed in the choice of fixed and moving images and the similarity metric for image registration. Distortions were measured in two important tracts for neurosurgery, the arcuate fasciculus and corticospinal tracts. Significant differences in distortion estimates were found across processing pipelines. The most successful pipeline used dMRI baseline and T2-weighted images as inputs for distortion correction. This pipeline gave the most consistent distortion estimates across image resolutions and brain hemispheres. Quantitative results of mean tract distortions on the order of 1-2 mm are in line with other recent studies, supporting the potential need for distortion correction in neurosurgical planning. Novel results include significantly higher distortion estimates in the tumor hemisphere and greater effect of image resolution choice on results in the tumor hemisphere. Overall, this study demonstrates possible pitfalls and indicates that care should be taken when implementing EPI distortion correction in clinical settings. Copyright © 2018 by the American Society of Neuroimaging.

  3. Software Defined Networking Demands on Software Technologies

    DEFF Research Database (Denmark)

    Galinac Grbac, T.; Caba, Cosmin Marius; Soler, José

    2015-01-01

    Software Defined Networking (SDN) is a networking approach based on a centralized control plane architecture with standardised interfaces between control and data planes. SDN enables fast configuration and reconfiguration of the network to enhance resource utilization and service performances....... This new approach enables a more dynamic and flexible network, which may adapt to user needs and application requirements. To this end, systemized solutions must be implemented in network software, aiming to provide secure network services that meet the required service performance levels. In this paper......, we review this new approach to networking from an architectural point of view, and identify and discuss some critical quality issues that require new developments in software technologies. These issues we discuss along with use case scenarios. Here in this paper we aim to identify challenges...

  4. Subsurface microbial ecology. Epi fluorescence direct counts; Ecologia microbica del sottosuolo: metodo di conta diretta in epifluorescenza

    Energy Technology Data Exchange (ETDEWEB)

    Barra Caracciolo, A.; Silvestri, C.; Creo, C.; Izzo, G. [ENEA, Centro Ricerche Casaccia, Rome (Italy). Dipt. Ambiente

    1998-07-01

    To the aim of recognize the importance of microorganisms in affecting or even determining the fate of xenobiotics in the subsurface environment evaluating bacteria concentration in a subsurface ecosystem, the report discusses a soil sample treatment method which has been developed for epi fluorescence direct counting with DAPI. [Italian] Lo studio discute un metodo di trattamento del campione per la conta diretta in epifluorescenza con un marcatore selettivo per il DNA, il DAPI, al fine di quantificare la concentrazione batterica del sottosuolo e studiare il ruolo dei microrganismi nella biodegradazione delle molecole esogene, ancora poco indagato.

  5. El epiLASIK como tratamiento en pacientes miopes con córneas de espesor reducido

    OpenAIRE

    Sabino Borreguero, Sara

    2011-01-01

    La principal hipótesis de este trabajo es que la que se plantea a continuación: “La técnica quirúrgica de ablación de superficie Queratectomía epitelial asistida por láser (epiLASIK) es un procedimiento predictible, seguro y eficaz en pacientes miopes con espesor de cornea central (ECC) menor de 500 micrómetros”. Tras la formulación de dicha hipótesis, el principal objetivo que se persigue en este trabajo es evaluar si los pacientes con ECC mayor y menor de 500 micrones tienen una buena...

  6. Info-Gap robustness pathway method for transitioning of urban drainage systems under deep uncertainties.

    Science.gov (United States)

    Zischg, Jonatan; Goncalves, Mariana L R; Bacchin, Taneha Kuzniecow; Leonhardt, Günther; Viklander, Maria; van Timmeren, Arjan; Rauch, Wolfgang; Sitzenfrei, Robert

    2017-09-01

    In the urban water cycle, there are different ways of handling stormwater runoff. Traditional systems mainly rely on underground piped, sometimes named 'gray' infrastructure. New and so-called 'green/blue' ambitions aim for treating and conveying the runoff at the surface. Such concepts are mainly based on ground infiltration and temporal storage. In this work a methodology to create and compare different planning alternatives for stormwater handling on their pathways to a desired system state is presented. Investigations are made to assess the system performance and robustness when facing the deeply uncertain spatial and temporal developments in the future urban fabric, including impacts caused by climate change, urbanization and other disruptive events, like shifts in the network layout and interactions of 'gray' and 'green/blue' structures. With the Info-Gap robustness pathway method, three planning alternatives are evaluated to identify critical performance levels at different stages over time. This novel methodology is applied to a real case study problem where a city relocation process takes place during the upcoming decades. In this case study it is shown that hybrid systems including green infrastructures are more robust with respect to future uncertainties, compared to traditional network design.

  7. Perencanaan dan Penataan Menara Telekomunikasi Seluler di Kabupaten Sidoarjo menggunakan MapInfo

    Directory of Open Access Journals (Sweden)

    Ervin Tri Sasongko

    2015-03-01

    Full Text Available Perkembangan teknologi dan industri telekomunikasi telah demikian pesatnya. Ketersediaan layanan diupayakan oleh sejumlah operator yang menawarkan berbagai sistem dan layanan yang bervariasi dengan pembangunan infrastruktur jaringan radio seluler, termasuk di dalamnya menara untuk antena BTS (Base Transceiver Station. Tetapi penempatan menara yang terlalu banyak dan tanpa perencanaan yang tepat akan menimbulkan efek yang kurang baik. Berdasarkan permasalahan yang telah diuraikan diatas, maka dapat diselesaikan dengan menyusun suatu master plan tentang penataan lokasi menara di wilayah Kabupaten Sidoarjo untuk 5 tahun mendatang. Penataan lokasi menara dilakukan dengan menggunakan peta MapInfo dan berdasarkan pada kebutuhan trafik pelanggan seluler, RTRW (Rencana Tata Ruang Wilayah Kabupaten Sidoarjo dan regulasi tentang peyelenggaraan menara telekomunikasi. Dalam perhitungan perencanaan kebutuhan BTS untuk tahun 2018, Kabupaten Sidoarjo membutuhkan 783 BTS yang ditopang oleh 454 menara telekomunikasi seluler bersama. Maka perlu dilakukan penambahan jumlah menara sebanyak 52 menara untuk mencukupi kebutuhan trafik pada tahun 2018. Jumlah penambahan menara tersebut akan ditempatkan di zona menara baru dengan luas total zona 14,6962 .

  8. Post-Inpatient Brain Injury Rehabilitation Outcomes: Report from the National OutcomeInfo Database.

    Science.gov (United States)

    Malec, James F; Kean, Jacob

    2016-07-15

    This study examined outcomes for intensive residential and outpatient/community-based post-inpatient brain injury rehabilitation (PBIR) programs compared with supported living programs. The goal of supported living programs was stable functioning (no change). Data were obtained for a large cohort of adults with acquired brain injury (ABI) from the OutcomeInfo national database, a web-based database system developed through National Institutes of Health (NIH) Small Business Technology Transfer (STTR) funding for monitoring progress and outcomes in PBIR programs primarily with the Mayo-Portland Adaptability Inventory (MPAI-4). Rasch-derived MPAI-4 measures for cases from 2008 to 2014 from 9 provider organizations offering programs in 23 facilities throughout the United States were examined. Controlling for age at injury, time in program, and time since injury on admission (chronicity), both intensive residential (n = 205) and outpatient/community-based (n = 2781) programs resulted in significant (approximately 1 standard deviation [SD]) functional improvement on the MPAI-4 Total Score compared with supported living (n = 101) programs (F = 18.184, p MPAI-4 Ability (F = 14.135, p 1 year post-injury) showed significant, but smaller (approximately 0.5 SD) change on the MPAI-4 relative to supported living programs (F = 17.562, p < 0.001). Results indicate that intensive residential and outpatient/community-based PIBR programs result in substantial positive functional changes moderated by chronicity.

  9. Pest insect olfaction in an insecticide-contaminated environment: info-disruption or hormesis effect.

    Science.gov (United States)

    Tricoire-Leignel, Hélène; Thany, Steeve Hervé; Gadenne, Christophe; Anton, Sylvia

    2012-01-01

    Most animals, including pest insects, live in an "odor world" and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs) are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an "info-disruptor" by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favoring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

  10. Support for victims of crime: Analysis of the VDS info and victim support service in 2010

    Directory of Open Access Journals (Sweden)

    Ćopić Sanja

    2011-01-01

    Full Text Available VDS info and victim support service is a victim support service, which was established in 2003 within the Victimology Society of Serbia. The service provides emotional support, information and, if necessary, referral to other relevant services, as well as witness support. The target group of the service are direct and indirect victims of all forms of crime, of both sexes, regardless of any personal characteristics. In addition, support is provided to victims in court, as well as to women victims of violence who are in prison. In most cases victim support is provided by volunteers who are trained to work with victims of crime. This paper analyzes the work of the service in 2010. Special attention is paid to the problems of workplace violence and domestic violence, which are the most common reasons for contacting the service. The aim of the paper is to present the work of the service in the past year, as well as to highlight the trends observed in comparison to the previous period.

  11. Pest insect olfaction in an insecticide-contaminated environment : info-disruption or hormesis effect

    Directory of Open Access Journals (Sweden)

    Hélène eTricoire-Leignel

    2012-03-01

    Full Text Available Most animals, including pest insects, live in an odour world and depend strongly on chemical stimuli to get information on their biotic and abiotic environment. Although integrated pest management strategies including the use of insect growth regulators (IGRs are increasingly developed, most insect pest treatments rely on neurotoxic chemicals. These molecules are known to disrupt synaptic transmission, affecting therefore sensory systems. The wide-spread use of neurotoxic insecticides and the growing use of IGRs result in residual accumulation of low concentrations in the environment. These insecticide residues could act as an info-disruptor by modifying the chemical communication system, and therefore decrease chances of reproduction in target insects. However, residues can also induce a non-expected hormesis effect by enhancing reproduction abilities. Low insecticide doses might thus induce adaptive processes in the olfactory pathway of target insects, favouring the development of resistance. The effect of sublethal doses of insecticides has mainly been studied in beneficial insects such as honeybees. We review here what is known on the effects of sublethal doses of insecticides on the olfactory system of insect pests.

  12. www.topten.info goes European. How to get Mr. Smith hooked to energy efficient appliances

    International Nuclear Information System (INIS)

    Attali, Sophie; Bush, Eric

    2005-01-01

    Topten is a consumer-oriented online search tool first created in Switzerland, which presents the 'best appliances' in various categories of products (white and brown goods, ITC, cars, lighting...). Energy efficiency is the key criteria. But Topten is more than an internet platform. It is a communication tool which helps to show how our energy consumption causes climate change and what we can do personally to reduce our impact. It is also a powerful instrument to influence manufacturers. Topten is independent of producers and retailers and relies on neutral tests and analyses of independent institutions and standardized declarations of manufacturers. The paper presents: The tool itself: what can be seen on www.topten.ch, why it has been developed in this way, how it is constantly updated, who is behind it with which goals... The results in Switzerland after five years of growing success, the media's central role in rising awareness, Topten's role as a reference for energy efficiency policies, manufacturers' reactions,... The new policy orientation taken by Topten with the support of WWF Europe: the extension to other countries through a Topten.info platform - in order to create multinational pressure at the European level to influence manufacturers while working specifically on national markets and adapting the concept to the specific needs of each country

  13. Survey of energy efficiency programs for motor systems in the industry and the main results of PROCEL Info; Levantamento dos programas de eficiencia energetica para sistemas motrizes na industria e os principais resultados do PROCEL Info

    Energy Technology Data Exchange (ETDEWEB)

    Naturesa, Jim Silva; Mariotoni, Carlos Alberto [Universidade Estadual de Campinas (GPESE/UNICAMP), SP (Brazil). Dept. de Recursos Hidricos, Energeticos e Ambientais. Grupo de Planejamento Energetico e Sistemas Eletricos; Menezes, Taciana de V.; Perrone, Fernando Pinto Dias; Lepetitgaland, Karla Kwiatkowski [Centrais Eletricas Brasileiras S.A. (ELETROBRAS), Brasilia, DF (Brazil)

    2008-07-01

    This article has as objective to compare the actual energy efficiency programs for the motor driven systems of Brazil, United States and European Community. This comparison will be restricted to the action of each program, considering that the countries present distinct economical, political and social aspects. The main results of PROCEL Info will be presented. (author)

  14. Software engineering in industry

    Science.gov (United States)

    Story, C. M.

    1989-12-01

    Can software be "engineered"? Can a few people with limited resources and a negligible budget produce high quality software solutions to complex software problems? It is possible to resolve the conflict between research activities and the necessity to view software development as a means to an end rather than as an end in itself? The aim of this paper is to encourage further thought and discussion on various topics which, in the author's experience, are becoming increasingly critical in large current software production and development projects, inside and outside high energy physics (HEP). This is done by briefly exploring some of the software engineering ideas and technologies now used in the information industry, using, as a case-study, a project with many similarities to those currently under way in HEP.

  15. A software product certification model

    NARCIS (Netherlands)

    Heck, P.M.; Klabbers, M.D.; van Eekelen, Marko

    2010-01-01

    Certification of software artifacts offers organizations more certainty and confidence about software. Certification of software helps software sales, acquisition, and can be used to certify legislative compliance or to achieve acceptable deliverables in outsourcing. In this article, we present a

  16. Software verification for nuclear industry

    International Nuclear Information System (INIS)

    Wilburn, N.P.

    1985-08-01

    Why verification of software products throughout the software life cycle is necessary is considered. Concepts of verification, software verification planning, and some verification methodologies for products generated throughout the software life cycle are then discussed

  17. Software evolution and maintenance

    CERN Document Server

    Tripathy, Priyadarshi

    2014-01-01

    Software Evolution and Maintenance: A Practitioner's Approach is an accessible textbook for students and professionals, which collates the advances in software development and provides the most current models and techniques in maintenance.Explains two maintenance standards: IEEE/EIA 1219 and ISO/IEC14764Discusses several commercial reverse and domain engineering toolkitsSlides for instructors are available onlineInformation is based on the IEEE SWEBOK (Software Engineering Body of Knowledge)

  18. Software for microcircuit systems

    International Nuclear Information System (INIS)

    Kunz, P.F.

    1978-10-01

    Modern Large Scale Integration (LSI) microcircuits are meant to be programed in order to control the function that they perform. The basics of microprograming and new microcircuits have already been discussed. In this course, the methods of developing software for these microcircuits are explored. This generally requires a package of support software in order to assemble the microprogram, and also some amount of support software to test the microprograms and to test the microprogramed circuit itself. 15 figures, 2 tables

  19. Hospital Management Software Development

    OpenAIRE

    sobogunGod, olawale

    2012-01-01

    The purpose of this thesis was to implement a hospital management software which is suitable for small private hospitals in Nigeria, especially for the ones that use a file based system for storing information rather than having it stored in a more efficient and safer environment like databases or excel programming software. The software developed within this thesis project was specifically designed for the Rainbow specialist hospital which is based in Lagos, the commercial neurological cente...

  20. Computer software configuration management

    International Nuclear Information System (INIS)

    Pelletier, G.

    1987-08-01

    This report reviews the basic elements of software configuration management (SCM) as defined by military and industry standards. Several software configuration management standards are evaluated given the requirements of the nuclear industry. A survey is included of available automated tools for supporting SCM activities. Some information is given on the experience of establishing and using SCM plans of other organizations that manage critical software. The report concludes with recommendations of practices that would be most appropriate for the nuclear power industry in Canada

  1. Gammasphere software development

    International Nuclear Information System (INIS)

    Piercey, R.B.

    1993-01-01

    Activities of the nuclear physics group are described. Progress was made in organizing the Gammasphere Software Working Group, establishing a nuclear computing facility, participating in software development at Lawrence Berkeley, developing a common data file format, and adapting the ORNL UPAK software to run at Gammasphere. A universal histogram object was developed that defines a file format and provides for an objective-oriented programming model. An automated liquid nitrogen fill system was developed for Gammasphere (110 Ge detectors comprise the sphere)

  2. Software quality management

    International Nuclear Information System (INIS)

    Bishop, D.C.; Pymm, P.

    1991-01-01

    As programmable electronic (software-based) systems are increasingly being proposed as design solutions for high integrity applications in nuclear power stations, the need to adopt suitable quality management arrangements is paramount. The authors describe Scottish Nuclear's strategy for software quality management and, using the main on-line monitoring system at Torness Power Station as an example, explain how this strategy is put into practice. Particular attention is given to the topics of software quality planning and change control. (author)

  3. Software Process Improvement Defined

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2002-01-01

    This paper argues in favor of the development of explanatory theory on software process improvement. The last one or two decades commitment to prescriptive approaches in software process improvement theory may contribute to the emergence of a gulf dividing theorists and practitioners....... It is proposed that this divide be met by the development of theory evaluating prescriptive approaches and informing practice with a focus on the software process policymaking and process control aspects of improvement efforts...

  4. Assuring Software Reliability

    Science.gov (United States)

    2014-08-01

    technologies and processes to achieve a required level of confidence that software systems and services function in the intended manner. 1.3 Security Example...that took three high-voltage lines out of service and a software fail- ure (a race condition3) that disabled the computing service that notified the... service had failed. Instead of analyzing the details of the alarm server failure, the reviewers asked why the following software assurance claim had

  5. Software evolution with XVCL

    DEFF Research Database (Denmark)

    Zhang, Weishan; Jarzabek, Stan; Zhang, Hongyu

    2004-01-01

    This chapter introduces software evolution with XVCL (XML-based Variant Configuration Language), which is an XML-based metaprogramming technique. As the software evolves, a large number of variants may arise, especially whtn such kinds of evolutions are related to multiple platforms as shown in our...... case study. Handling variants and tracing the impact of variants across the development lifecycle is a challenge. This chapter shows how we can maintain different versions of software in a reuse-based way....

  6. FASTBUS software status

    International Nuclear Information System (INIS)

    Gustavson, D.B.

    1980-10-01

    Computer software will be needed in addition to the mechanical, electrical, protocol and timing specifications of the FASTBUS, in order to facilitate the use of this flexible new multiprocessor and multisegment data acquisition and processing system. Software considerations have been important in the FASTBUS design, but standard subroutines and recommended algorithms will be needed as the FASTBUS comes into use. This paper summarizes current FASTBUS software projects, goals and status

  7. Software configuration management

    CERN Document Server

    Keyes, Jessica

    2004-01-01

    Software Configuration Management discusses the framework from a standards viewpoint, using the original DoD MIL-STD-973 and EIA-649 standards to describe the elements of configuration management within a software engineering perspective. Divided into two parts, the first section is composed of 14 chapters that explain every facet of configuration management related to software engineering. The second section consists of 25 appendices that contain many valuable real world CM templates.

  8. Solar Asset Management Software

    Energy Technology Data Exchange (ETDEWEB)

    Iverson, Aaron [Ra Power Management, Inc., Oakland, CA (United States); Zviagin, George [Ra Power Management, Inc., Oakland, CA (United States)

    2016-09-30

    Ra Power Management (RPM) has developed a cloud based software platform that manages the financial and operational functions of third party financed solar projects throughout their lifecycle. RPM’s software streamlines and automates the sales, financing, and management of a portfolio of solar assets. The software helps solar developers automate the most difficult aspects of asset management, leading to increased transparency, efficiency, and reduction in human error. More importantly, our platform will help developers save money by improving their operating margins.

  9. Essential software architecture

    CERN Document Server

    Gorton, Ian

    2011-01-01

    Job titles like ""Technical Architect"" and ""Chief Architect"" nowadays abound in software industry, yet many people suspect that ""architecture"" is one of the most overused and least understood terms in professional software development. Gorton's book tries to resolve this dilemma. It concisely describes the essential elements of knowledge and key skills required to be a software architect. The explanations encompass the essentials of architecture thinking, practices, and supporting technologies. They range from a general understanding of structure and quality attributes through technical i

  10. Software engineering the current practice

    CERN Document Server

    Rajlich, Vaclav

    2011-01-01

    INTRODUCTION History of Software EngineeringSoftware PropertiesOrigins of SoftwareBirth of Software EngineeringThird Paradigm: Iterative ApproachSoftware Life Span ModelsStaged ModelVariants of Staged ModelSoftware Technologies Programming Languages and CompilersObject-Oriented TechnologyVersion Control SystemSoftware ModelsClass DiagramsUML Activity DiagramsClass Dependency Graphs and ContractsSOFTWARE CHANGEIntroduction to Software ChangeCharacteristics of Software ChangePhases of Software ChangeRequirements and Their ElicitationRequirements Analysis and Change InitiationConcepts and Concept

  11. Agile software development

    CERN Document Server

    Dingsoyr, Torgeir; Moe, Nils Brede

    2010-01-01

    Agile software development has become an umbrella term for a number of changes in how software developers plan and coordinate their work, how they communicate with customers and external stakeholders, and how software development is organized in small, medium, and large companies, from the telecom and healthcare sectors to games and interactive media. Still, after a decade of research, agile software development is the source of continued debate due to its multifaceted nature and insufficient synthesis of research results. Dingsoyr, Dyba, and Moe now present a comprehensive snapshot of the kno

  12. Optimization of Antivirus Software

    Directory of Open Access Journals (Sweden)

    2007-01-01

    Full Text Available The paper describes the main techniques used in development of computer antivirus software applications. For this particular category of software, are identified and defined optimum criteria that helps determine which solution is better and what are the objectives of the optimization process. From the general viewpoint of software optimization are presented methods and techniques that are applied at code development level. Regarding the particularities of antivirus software, the paper analyzes some of the optimization concepts applied to this category of applications

  13. Dtest Testing Software

    Science.gov (United States)

    Jain, Abhinandan; Cameron, Jonathan M.; Myint, Steven

    2013-01-01

    This software runs a suite of arbitrary software tests spanning various software languages and types of tests (unit level, system level, or file comparison tests). The dtest utility can be set to automate periodic testing of large suites of software, as well as running individual tests. It supports distributing multiple tests over multiple CPU cores, if available. The dtest tool is a utility program (written in Python) that scans through a directory (and its subdirectories) and finds all directories that match a certain pattern and then executes any tests in that directory as described in simple configuration files.

  14. Software quality assurance

    CERN Document Server

    Laporte, Claude Y

    2018-01-01

    This book introduces Software Quality Assurance (SQA) and provides an overview of standards used to implement SQA. It defines ways to assess the effectiveness of how one approaches software quality across key industry sectors such as telecommunications, transport, defense, and aerospace. * Includes supplementary website with an instructor's guide and solutions * Applies IEEE software standards as well as the Capability Maturity Model Integration for Development (CMMI) * Illustrates the application of software quality assurance practices through the use of practical examples, quotes from experts, and tips from the authors

  15. Software architecture 2

    CERN Document Server

    Oussalah, Mourad Chabanne

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural templa

  16. Software as quality product

    International Nuclear Information System (INIS)

    Enders, A.

    1975-01-01

    In many discussions on the reliability of computer systems, software is presented as the weak link in the chain. The contribution attempts to identify the reasons for this situation as seen from the software development. The concepts correctness and reliability of programmes are explained as they are understood in the specialist discussion of today. Measures and methods are discussed which are particularly relevant as far as the obtaining of fault-free and reliable programmes is concerned. Conclusions are drawn for the user of software so that he is in the position to judge himself what can be justly expected frm the product software compared to other products. (orig./LH) [de

  17. Essence: Facilitating Software Innovation

    DEFF Research Database (Denmark)

    Aaen, Ivan

    2008-01-01

      This paper suggests ways to facilitate creativity and innovation in software development. The paper applies four perspectives – Product, Project, Process, and People –to identify an outlook for software innovation. The paper then describes a new facility–Software Innovation Research Lab (SIRL......) – and a new method concept for software innovation – Essence – based on views, modes, and team roles. Finally, the paper reports from an early experiment using SIRL and Essence and identifies further research....

  18. Global Software Engineering

    DEFF Research Database (Denmark)

    Ebert, Christof; Kuhrmann, Marco; Prikladnicki, Rafael

    2016-01-01

    Professional software products and IT systems and services today are developed mostly by globally distributed teams, projects, and companies. Successfully orchestrating Global Software Engineering (GSE) has become the major success factor both for organizations and practitioners. Yet, more than...... and experience reported at the IEEE International Conference on Software Engineering (ICGSE) series. The outcomes of our analysis show GSE as a field highly attached to industry and, thus, a considerable share of ICGSE papers address the transfer of Software Engineering concepts and solutions to the global stage...

  19. Software Intensive Systems

    National Research Council Canada - National Science Library

    Horvitz, E; Katz, D. J; Rumpf, R. L; Shrobe, H; Smith, T. B; Webber, G. E; Williamson, W. E; Winston, P. H; Wolbarsht, James L

    2006-01-01

    .... Additionally, recommend that DoN invest in software engineering, particularly as it complements commercial industry developments and promotes the application of systems engineering methodology...

  20. Contractor Software Charges

    National Research Council Canada - National Science Library

    Granetto, Paul

    1994-01-01

    .... Examples of computer software costs that contractors charge through indirect rates are material management systems, security systems, labor accounting systems, and computer-aided design and manufacturing...

  1. Decentralized Software Architecture

    National Research Council Canada - National Science Library

    Khare, Rohit

    2002-01-01

    .... While the term "decentralization" is familiar from political and economic contexts, it has been applied extensively, if indiscriminately, to describe recent trends in software architecture towards...

  2. Software architecture 1

    CERN Document Server

    Oussalah , Mourad Chabane

    2014-01-01

    Over the past 20 years, software architectures have significantly contributed to the development of complex and distributed systems. Nowadays, it is recognized that one of the critical problems in the design and development of any complex software system is its architecture, i.e. the organization of its architectural elements. Software Architecture presents the software architecture paradigms based on objects, components, services and models, as well as the various architectural techniques and methods, the analysis of architectural qualities, models of representation of architectural template

  3. Software Radar Technology

    Directory of Open Access Journals (Sweden)

    Tang Jun

    2015-08-01

    Full Text Available In this paper, the definition and the key features of Software Radar, which is a new concept, are proposed and discussed. We consider the development of modern radar system technology to be divided into three stages: Digital Radar, Software radar and Intelligent Radar, and the second stage is just commencing now. A Software Radar system should be a combination of various modern digital modular components conformed to certain software and hardware standards. Moreover, a software radar system with an open system architecture supporting to decouple application software and low level hardware would be easy to adopt "user requirements-oriented" developing methodology instead of traditional "specific function-oriented" developing methodology. Compared with traditional Digital Radar, Software Radar system can be easily reconfigured and scaled up or down to adapt to the changes of requirements and technologies. A demonstration Software Radar signal processing system, RadarLab 2.0, which has been developed by Tsinghua University, is introduced in this paper and the suggestions for the future development of Software Radar in China are also given in the conclusion.

  4. Social software in global software development

    DEFF Research Database (Denmark)

    Giuffrida, Rosalba; Dittrich, Yvonne

    2010-01-01

    variety of tools such as: instant messaging, internet forums, mailing lists, blogs, wikis, social network sites, social bookmarking, social libraries, virtual worlds. Though normally rather belonging to the private realm, the use of social software in corporate context has been reported, e.g. as a way...

  5. Quando o humor azeda: o episódio Rushdie em retrospectiva

    Directory of Open Access Journals (Sweden)

    Kanavillil Rajagopalan

    1996-08-01

    Full Text Available Este trabalho é uma tentativa de analisar retrospectivamente o episódio que envolve Salman Rushdie e seu romance Os versículos satânicos. Começo minha análise chamando atenção para o fato de que tanto o enredo da obra quanto o ambiente sócio-político-histórico em que ela aparece estão mergulhados no meio cultural da Índia de modo a não surpreender que o romance tenha se transformado numa questão tão explosiva no cenário internacional. Em seguida argumento que isso tudo nos ensina uma lição importante a respeito de leitura e interpretação. O que quer que Rushdie ou outra pessoa fizesse com o intuito de voltar atrás ou pedir clemência aos aiotolás enfurecidos, não havia como submeter o romance a uma re-leitura - a única interpretação final e definitiva já havia sindo impingida ao malfadado romance. Essa é a enrascada pós-moderna de Rushdie. A ironia - a mesma arma que ele tão habilmente havia utilizado não apenas nos Versículos satânicos mas também em seus romances anteriores - voltou-se contra ele, produzindo um inesperado efeito bumerangue. O que temos aqui é um caso de política da ironia em ação.This paper is an attempt to review in retrospect the episode involving Salman Rushdie and his novel The satanic verses. I begin my analysis by calling attention to the fact that both the plot of the novel and the socio-historico-political backdrop against which it is projected are so steeped in India's cultural milieu that it is indeed surprising that the novel became such an explosive issue on the international scenario. But then I argue that there is an important lesson to be learned from all this concerning reading and interpretation. No matter what Rushdie or anybody else could possibly have done by way of retracing the steps or pleading with Iran's enraged ayatollahs for clemency, there was no way his novel could have been subjected to a re-reading - the one final and definitive interpretation had already

  6. NASA's Software Safety Standard

    Science.gov (United States)

    Ramsay, Christopher M.

    2007-01-01

    NASA relies more and more on software to control, monitor, and verify its safety critical systems, facilities and operations. Since the 1960's there has hardly been a spacecraft launched that does not have a computer on board that will provide command and control services. There have been recent incidents where software has played a role in high-profile mission failures and hazardous incidents. For example, the Mars Orbiter, Mars Polar Lander, the DART (Demonstration of Autonomous Rendezvous Technology), and MER (Mars Exploration Rover) Spirit anomalies were all caused or contributed to by software. The Mission Control Centers for the Shuttle, ISS, and unmanned programs are highly dependant on software for data displays, analysis, and mission planning. Despite this growing dependence on software control and monitoring, there has been little to no consistent application of software safety practices and methodology to NASA's projects with safety critical software. Meanwhile, academia and private industry have been stepping forward with procedures and standards for safety critical systems and software, for example Dr. Nancy Leveson's book Safeware: System Safety and Computers. The NASA Software Safety Standard, originally published in 1997, was widely ignored due to its complexity and poor organization. It also focused on concepts rather than definite procedural requirements organized around a software project lifecycle. Led by NASA Headquarters Office of Safety and Mission Assurance, the NASA Software Safety Standard has recently undergone a significant update. This new standard provides the procedures and guidelines for evaluating a project for safety criticality and then lays out the minimum project lifecycle requirements to assure the software is created, operated, and maintained in the safest possible manner. This update of the standard clearly delineates the minimum set of software safety requirements for a project without detailing the implementation for those

  7. 2018-05-15T22:36:01Z https://www.ajol.info/index.php/index/oai oai ...

    African Journals Online (AJOL)

    They are aware that the bees collect nectar and pollen and also know that the ... Even though the indigenous people recognize stingless bee honey as highly ... Article application/pdf https://www.ajol.info/index.php/jgsa/article/view/48073 ...

  8. The Experience of Persons With Multiple Sclerosis Using MS INFoRm: An Interactive Fatigue Management Resource.

    Science.gov (United States)

    Pétrin, Julie; Akbar, Nadine; Turpin, Karen; Smyth, Penelope; Finlayson, Marcia

    2018-04-01

    We aimed to understand participants' experiences with a self-guided fatigue management resource, Multiple Sclerosis: An Interactive Fatigue Management Resource ( MS INFoRm), and the extent to which they found its contents relevant and useful to their daily lives. We recruited 35 persons with MS experiencing mild to moderate fatigue, provided them with MS INFoRm, and then conducted semistructured interviews 3 weeks and 3 months after they received the resource. Interpretive description guided the analysis process. Findings indicate that participants' experience of using MS INFoRm could be understood as a process of change, influenced by their initial reactions to the resource. They reported experiencing a shift in knowledge, expectations, and behaviors with respect to fatigue self-management. These shifts led to multiple positive outcomes, including increased levels of self-confidence and improved quality of life. These findings suggest that MS INFoRm may have a place in the continuum of fatigue management interventions for people with MS.

  9. Validation of a screening tool for attention and executive functions (EpiTrack Junior) in children and adolescents with absence epilepsy.

    Science.gov (United States)

    Kadish, Navah Ester; Baumann, Matthias; Pietz, Joachim; Schubert-Bast, Susanne; Reuner, Gitta

    2013-10-01

    Our prospective study aimed at the validation of EpiTrack Junior, a neuropsychological screening tool for attention and executive functions in children with epilepsy. Twenty-two children with absence epilepsy aged 8-17 years underwent comprehensive neuropsychological evaluation including EpiTrack Junior and measures of intelligence, verbal and nonverbal memory, word fluency and visuoconstructive organization. Concurrent and discriminant validity of EpiTrack Junior subtests and total score as well as sensitivity and specificity of the total score were analyzed. EpiTrack Junior total score was impaired in 59% of participants. Concurrent validity was demonstrated in 4/6 subtests and for the total score. Discriminant validity was shown with respect to verbal and nonverbal long-term memory. Sensitivity was higher than specificity and highest for the "working memory index". EpiTrack Junior is recommended as a sensitive and time-efficient screening tool for attention and executive functions in children with epilepsy. Impaired results should be followed up with detailed evaluation including information from the parents and school as well as counseling where indicated. © 2013.

  10. Customer Interaction in Software Development: A Comparison of Software Methodologies Deployed in Namibian Software Firms

    CSIR Research Space (South Africa)

    Iyawa, GE

    2016-01-01

    Full Text Available within the Namibian context. An implication for software project managers and software developers is that customer interaction should be properly managed to ensure that the software methodologies for improving software development processes...

  11. EnviroInfo 2013. Environmental informatics and renewable energies. Proceedings. Pt. II

    Energy Technology Data Exchange (ETDEWEB)

    Page, Bernd; Fleischer, Andreas G.; Goebel, Johannes; Wohlgemuth, Volker (eds.)

    2013-07-01

    The second part of this conference book contains contributions to the following main topics: Sustainability; Sustainable simulation of manufacturing systems; Scaleable software solutions to support resource efficiency questions in SMEs: Concepts, applications, development; Environmental management information systems; Open government data, linked open data and eGovernment; GIS; Modelling environmental systems; Ecological systems; Environmental assessment and health. Furthermore it contains five contributions of the student workshop.

  12. EnviroInfo 2013. Environmental informatics and renewable energies. Proceedings. Pt. II

    International Nuclear Information System (INIS)

    Page, Bernd; Fleischer, Andreas G.; Goebel, Johannes; Wohlgemuth, Volker

    2013-01-01

    The second part of this conference book contains contributions to the following main topics: Sustainability; Sustainable simulation of manufacturing systems; Scaleable software solutions to support resource efficiency questions in SMEs: Concepts, applications, development; Environmental management information systems; Open government data, linked open data and eGovernment; GIS; Modelling environmental systems; Ecological systems; Environmental assessment and health. Furthermore it contains five contributions of the student workshop.

  13. In vivo flow cytometry for blood cell analysis using differential epi-detection of forward scattered light

    Science.gov (United States)

    Paudel, Hari P.; Jung, Yookyung; Raphael, Anthony; Alt, Clemens; Wu, Juwell; Runnels, Judith; Lin, Charles P.

    2018-02-01

    The present standard of blood cell analysis is an invasive procedure requiring the extraction of patient's blood, followed by ex-vivo analysis using a flow cytometer or a hemocytometer. We are developing a noninvasive optical technique that alleviates the need for blood extraction. For in-vivo blood analysis we need a high speed, high resolution and high contrast label-free imaging technique. In this proceeding report, we reported a label-free method based on differential epi-detection of forward scattered light, a method inspired by Jerome Mertz's oblique back-illumination microscopy (OBM) (Ford et al, Nat. Meth. 9(12) 2012). The differential epi-detection of forward light gives phase contrast image at diffraction-limited resolution. Unlike reflection confocal microscopy (RCM), which detects only sharp refractive index variation and suffers from speckle noise, this technique is suitable for detection of subtle variation of refractive index in biological tissue and it provides the shape and the size of cells. A custom built high speed electronic detection circuit board produces a real-time differential signal which yields image contrast based on phase gradient in the sample. We recorded blood flow in-vivo at 17.2k lines per second in line scan mode, or 30 frames per second (full frame), or 120 frame per second (quarter frame) in frame scan mode. The image contrast and speed of line scan data recording show the potential of the system for noninvasive blood cell analysis.

  14. Reliability of CKD-EPI predictive equation in estimating chronic kidney disease prevalence in the Croatian endemic nephropathy area.

    Science.gov (United States)

    Fuček, Mirjana; Dika, Živka; Karanović, Sandra; Vuković Brinar, Ivana; Premužić, Vedran; Kos, Jelena; Cvitković, Ante; Mišić, Maja; Samardžić, Josip; Rogić, Dunja; Jelaković, Bojan

    2018-02-15

    Chronic kidney disease (CKD) is a significant public health problem and it is not possible to precisely predict its progression to terminal renal failure. According to current guidelines, CKD stages are classified based on the estimated glomerular filtration rate (eGFR) and albuminuria. Aims of this study were to determine the reliability of predictive equation in estimation of CKD prevalence in Croatian areas with endemic nephropathy (EN), compare the results with non-endemic areas, and to determine if the prevalence of CKD stages 3-5 was increased in subjects with EN. A total of 1573 inhabitants of the Croatian Posavina rural area from 6 endemic and 3 non-endemic villages were enrolled. Participants were classified according to the modified criteria of the World Health Organization for EN. Estimated GFR was calculated using Chronic Kidney Disease Epidemiology Collaboration equation (CKD-EPI). The results showed a very high CKD prevalence in the Croatian rural area (19%). CKD prevalence was significantly higher in EN then in non EN villages with the lowest eGFR value in diseased subgroup. eGFR correlated significantly with the diagnosis of EN. Kidney function assessment using CKD-EPI predictive equation proved to be a good marker in differentiating the study subgroups, remained as one of the diagnostic criteria for EN.

  15. Fluorescence single-molecule counting assays for protein quantification using epi-fluorescence microscopy with quantum dots labeling

    International Nuclear Information System (INIS)

    Jiang Dafeng; Liu Chunxia; Wang Lei; Jiang Wei

    2010-01-01

    A single-molecule counting approach for quantifying the antibody affixed to a surface using quantum dots and epi-fluorescence microscopy is presented. Modifying the glass substrates with carboxyl groups provides a hydrophilic surface that reacts with amine groups of an antibody to allow covalent immobilization of the antibody. Nonspecific adsorption of single molecules on the modified surfaces was first investigated. Then, quantum dots were employed to form complexes with surface-immobilized antibody molecules and used as fluorescent probes for single-molecule imaging. Epi-fluorescence microscopy was chosen as the tool for single-molecule fluorescence detection here. The generated fluorescence signals were taken by an electron multiplying charge-coupled device and were found to be proportional to the sample concentrations. Under optimal conditions, a linear response range of 5.0 x 10 -14 -3.0 x 10 -12 mol L -1 was obtained between the number of single molecules and sample concentration via a single-molecule counting approach.

  16. Self-interference fluorescence microscopy with three-phase detection for depth-resolved confocal epi-fluorescence imaging.

    Science.gov (United States)

    Braaf, Boy; de Boer, Johannes F

    2017-03-20

    Three-dimensional confocal fluorescence imaging of in vivo tissues is challenging due to sample motion and limited imaging speeds. In this paper a novel method is therefore presented for scanning confocal epi-fluorescence microscopy with instantaneous depth-sensing based on self-interference fluorescence microscopy (SIFM). A tabletop epi-fluorescence SIFM setup was constructed with an annular phase plate in the emission path to create a spectral self-interference signal that is phase-dependent on the axial position of a fluorescent sample. A Mach-Zehnder interferometer based on a 3 × 3 fiber-coupler was developed for a sensitive phase analysis of the SIFM signal with three photon-counter detectors instead of a spectrometer. The Mach-Zehnder interferometer created three intensity signals that alternately oscillated as a function of the SIFM spectral phase and therefore encoded directly for the axial sample position. Controlled axial translation of fluorescent microsphere layers showed a linear dependence of the SIFM spectral phase with sample depth over axial image ranges of 500 µm and 80 µm (3.9 × Rayleigh range) for 4 × and 10 × microscope objectives respectively. In addition, SIFM was in good agreement with optical coherence tomography depth measurements on a sample with indocyanine green dye filled capillaries placed at multiple depths. High-resolution SIFM imaging applications are demonstrated for fluorescence angiography on a dye-filled capillary blood vessel phantom and for autofluorescence imaging on an ex vivo fly eye.

  17. data.reegle.info. A New Key Portal for Open Energy Data

    Energy Technology Data Exchange (ETDEWEB)

    Bauer, F.; Recheis, D. [Renewable Energy and Energy Efficiency Partnership REEEP, Wagramerstrasse 5, 1400 Vienna (Austria); Kaltenboeck, M. [Semantic Web Company, Vienna (Austria)

    2011-07-15

    Over the last few centuries knowledge and information has become much more widely available. It is no longer limited to a select few; more often it is available to anyone, anywhere with an internet connection and access to a computer. A major step forward was the invention of the printing press, resulting in greater access to information, higher literacy rates and improved levels of education. This sharing of knowledge has been radically transformed again recently with the onset of the internet combined with rapid technology advances. Linked Open Data is the next step along those lines, offering us opportunities to use the latest technologies and techniques available to share pertinent, up-to-date information, from a wider variety of sources free for use and re-use. One of the main challenges now is to sort through this ever increasing volume of information, of varying quality; to select the most relevant, up-to-date and reliable information from the different sources and formats in use; and to make this information available in a useful, reliable and standardised way. The information gateway data.reegle.info, which is at the forefront of this development, is consuming and publishing energy related data in a machine-readable format so as to allow the flexible sharing and re-use of information in new and innovative ways. It filters and enriches content by sorting and adding pertinent information from various reliable sources. It enables data providers to easily link and publish datasets in a standardised, machine-readable format. In this way it can be easily accessible, and shared with third parties. This is a real benefit for the users of reegle which targets policy- and decision makers, developers and the general public with an interest in renewable energy and energy efficiency, with a focus on developing countries.

  18. Marketing Mix del Software.

    Directory of Open Access Journals (Sweden)

    Yudith del Carmen Rodríguez Pérez

    2006-03-01

    Por ello, en este trabajo se define el concepto de producto software, se caracteriza al mismo y se exponen sus atributos de calidad. Además, se aborda la mezcla de marketing del software necesaria y diferente a la de otros productos para que este triunfe en el mercado.

  19. Sustainability in Software Engineering

    NARCIS (Netherlands)

    Wolfram, N.J.E.; Lago, P.; Osborne, Francesco

    2017-01-01

    The intersection between software engineering research and issues related to sustainability and green IT has been the subject of increasing attention. In spite of that, we observe that sustainability is still not clearly defined, or understood, in the field of software engineering. This lack of

  20. Software cost estimation

    NARCIS (Netherlands)

    Heemstra, F.J.

    1992-01-01

    The paper gives an overview of the state of the art of software cost estimation (SCE). The main questions to be answered in the paper are: (1) What are the reasons for overruns of budgets and planned durations? (2) What are the prerequisites for estimating? (3) How can software development effort be

  1. Software cost estimation

    NARCIS (Netherlands)

    Heemstra, F.J.; Heemstra, F.J.

    1993-01-01

    The paper gives an overview of the state of the art of software cost estimation (SCE). The main questions to be answered in the paper are: (1) What are the reasons for overruns of budgets and planned durations? (2) What are the prerequisites for estimating? (3) How can software development effort be

  2. Software engineering ethics

    Science.gov (United States)

    Bown, Rodney L.

    1991-01-01

    Software engineering ethics is reviewed. The following subject areas are covered: lack of a system viewpoint; arrogance of PC DOS software vendors; violation od upward compatibility; internet worm; internet worm revisited; student cheating and company hiring interviews; computing practitioners and the commodity market; new projects and old programming languages; schedule and budget; and recent public domain comments.

  3. Computer Software Reviews.

    Science.gov (United States)

    Hawaii State Dept. of Education, Honolulu. Office of Instructional Services.

    Intended to provide guidance in the selection of the best computer software available to support instruction and to make optimal use of schools' financial resources, this publication provides a listing of computer software programs that have been evaluated according to their currency, relevance, and value to Hawaii's educational programs. The…

  4. Software product family evaluation

    NARCIS (Netherlands)

    van der Linden, F; Bosch, J; Kamsties, E; Kansala, K; Krzanik, L; Obbink, H; VanDerLinden, F

    2004-01-01

    This paper proposes a 4-dimensional software product family engineering evaluation model. The 4 dimensions relate to the software engineering concerns of business, architecture, organisation and process. The evaluation model is meant to be used within organisations to determine the status of their

  5. Selecting the Right Software.

    Science.gov (United States)

    Shearn, Joseph

    1987-01-01

    Selection of administrative software requires analyzing present needs and, to meet future needs, choosing software that will function with a more powerful computer system. Other important factors to include are a professional system demonstration, maintenance and training, and financial considerations that allow leasing or renting alternatives.…

  6. osni.info-Using free/libre/open source software to build a virtual international community for open source nursing informatics.

    Science.gov (United States)

    Oyri, Karl; Murray, Peter J

    2005-12-01

    Many health informatics organizations seem to be slow to take up the advantages of dynamic, web-based technologies for providing services to, and interaction with, their members; these are often the very technologies they promote for use within healthcare environments. This paper aims to introduce some of the many free/libre/open source (FLOSS) applications that are now available to develop interactive websites and dynamic online communities as part of the structure of health informatics organizations, and to show how the Open Source Nursing Informatics Working Group (OSNI) of the special interest group in nursing informatics of the International Medical Informatics Association (IMIA-NI) is using some of these tools to develop an online community of nurse informaticians through their website, at . Some background introduction to FLOSS applications is used for the benefit of those less familiar with such tools, and examples of some of the FLOSS content management systems (CMS) being used by OSNI are described. The experiences of the OSNI will facilitate a knowledgeable nursing contribution to the wider discussions on the applications of FLOSS within health and healthcare, and provides a model that many other groups could adopt.

  7. Cosmic Deuterium and Social Networking Software

    Science.gov (United States)

    Pasachoff, J. M.; Suer, T.-A.; Lubowich, D. A.; Glaisyer, T.

    2006-08-01

    For the education of newcomers to a scientific field and for the convenience of students and workers in the field, it is helpful to have all the basic scientific papers gathered. For the study of deuterium in the Universe, in 2004-5 we set up http://www.cosmicdeuterium.info with clickable links to all the historic and basic papers in the field and to many of the current papers. Cosmic deuterium is especially important because all deuterium in the Universe was formed in the epoch of nucleosynthesis in the first 1000 seconds after the Big Bang, so study of its relative abundance (D:H~1:100,000) gives us information about those first minutes of the Universe's life. Thus the understanding of cosmic deuterium is one of the pillars of modern cosmology, joining the cosmic expansion, the 3 degree cosmic background radiation, and the ripples in that background radiation. Studies of deuterium are also important for understanding Galactic chemical evolution, astrochemistry, interstellar processes, and planetary formation. Some papers had to be scanned while others are available at the Astrophysical Data System, adswww.harvard.edu, or to publishers' Websites. By 2006, social networking software (http:tinyurl.com/ zx5hk) had advanced with popular sites like facebook.com and MySpace.com; the Astrophysical Data System had even set up MyADS. Social tagging software sites like http://del.icio.us have made it easy to share sets of links to papers already available online. We have set up http://del.icio.us/deuterium to provide links to many of the papers on cosmicdeuterium.info, furthering previous del.icio.us work on /eclipses and /plutocharon. It is easy for the site owner to add links to a del.icio.us site; it takes merely clicking on a button on the browser screen once the site is opened and the desired link is viewed in a browser. Categorizing different topics by keywords allows subsets to be easily displayed. The opportunity to expose knowledge and build an ecosystem of web

  8. Trends in software testing

    CERN Document Server

    Mohanty, J; Balakrishnan, Arunkumar

    2017-01-01

    This book is focused on the advancements in the field of software testing and the innovative practices that the industry is adopting. Considering the widely varied nature of software testing, the book addresses contemporary aspects that are important for both academia and industry. There are dedicated chapters on seamless high-efficiency frameworks, automation on regression testing, software by search, and system evolution management. There are a host of mathematical models that are promising for software quality improvement by model-based testing. There are three chapters addressing this concern. Students and researchers in particular will find these chapters useful for their mathematical strength and rigor. Other topics covered include uncertainty in testing, software security testing, testing as a service, test technical debt (or test debt), disruption caused by digital advancement (social media, cloud computing, mobile application and data analytics), and challenges and benefits of outsourcing. The book w...

  9. Revisiting software ecosystems research

    DEFF Research Database (Denmark)

    Manikas, Konstantinos

    2016-01-01

    Software ecosystems’ is argued to first appear as a concept more than 10 years ago and software ecosystem research started to take off in 2010. We conduct a systematic literature study, based on the most extensive literature review in the field up to date, with two primarily aims: (a) to provide...... an updated overview of the field and (b) to document evolution in the field. In total, we analyze 231 papers from 2007 until 2014 and provide an overview of the research in software ecosystems. Our analysis reveals a field that is rapidly growing both in volume and empirical focus while becoming more mature...... from evolving. We propose means for future research and the community to address them. Finally, our analysis shapes the view of the field having evolved outside the existing definitions of software ecosystems and thus propose the update of the definition of software ecosystems....

  10. Software safety hazard analysis

    International Nuclear Information System (INIS)

    Lawrence, J.D.

    1996-02-01

    Techniques for analyzing the safety and reliability of analog-based electronic protection systems that serve to mitigate hazards in process control systems have been developed over many years, and are reasonably well understood. An example is the protection system in a nuclear power plant. The extension of these techniques to systems which include digital computers is not well developed, and there is little consensus among software engineering experts and safety experts on how to analyze such systems. One possible technique is to extend hazard analysis to include digital computer-based systems. Software is frequently overlooked during system hazard analyses, but this is unacceptable when the software is in control of a potentially hazardous operation. In such cases, hazard analysis should be extended to fully cover the software. A method for performing software hazard analysis is proposed in this paper

  11. Systematic Software Development

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Méndez Fernández, Daniel

    2015-01-01

    The speed of innovation and the global allocation of resources to accelerate development or to reduce cost put pressure on the software industry. In the global competition, especially so-called high-price countries have to present arguments why the higher development cost is justified and what...... makes these countries an attractive host for software companies. Often, high-quality engineering and excellent quality of products, e.g., machinery and equipment, are mentioned. Yet, the question is: Can such arguments be also found for the software industry? We aim at investigating the degree...... of professionalism and systematization of software development to draw a map of strengths and weaknesses. To this end, we conducted as a first step an exploratory survey in Germany, presented in this paper. In this survey, we focused on the perceived importance of the two general software engineering process areas...

  12. Software architecture evolution

    DEFF Research Database (Denmark)

    Barais, Olivier; Le Meur, Anne-Francoise; Duchien, Laurence

    2008-01-01

    Software architectures must frequently evolve to cope with changing requirements, and this evolution often implies integrating new concerns. Unfortunately, when the new concerns are crosscutting, existing architecture description languages provide little or no support for this kind of evolution....... The software architect must modify multiple elements of the architecture manually, which risks introducing inconsistencies. This chapter provides an overview, comparison and detailed treatment of the various state-of-the-art approaches to describing and evolving software architectures. Furthermore, we discuss...... one particular framework named Tran SAT, which addresses the above problems of software architecture evolution. Tran SAT provides a new element in the software architecture descriptions language, called an architectural aspect, for describing new concerns and their integration into an existing...

  13. Software quality in 1997

    Energy Technology Data Exchange (ETDEWEB)

    Jones, C. [Software Productivity Research, Inc., Burlington, MA (United States)

    1997-11-01

    For many years, software quality assurance lagged behind hardware quality assurance in terms of methods, metrics, and successful results. New approaches such as Quality Function Deployment (QFD) the ISO 9000-9004 standards, the SEI maturity levels, and Total Quality Management (TQM) are starting to attract wide attention, and in some cases to bring software quality levels up to a parity with manufacturing quality levels. Since software is on the critical path for many engineered products, and for internal business systems as well, the new approaches are starting to affect global competition and attract widespread international interest. It can be hypothesized that success in mastering software quality will be a key strategy for dominating global software markets in the 21st century.

  14. Developing Software Simulations

    Directory of Open Access Journals (Sweden)

    Tom Hall

    2007-06-01

    Full Text Available Programs in education and business often require learners to develop and demonstrate competence in specified areas and then be able to effectively apply this knowledge. One method to aid in developing a skill set in these areas is through the use of software simulations. These simulations can be used for learner demonstrations of competencies in a specified course as well as a review of the basic skills at the beginning of subsequent courses. The first section of this paper discusses ToolBook, the software used to develop our software simulations. The second section discusses the process of developing software simulations. The third part discusses how we have used software simulations to assess student knowledge of research design by providing simulations that allow the student to practice using SPSS and Excel.

  15. Software licenses: Stay honest!

    CERN Multimedia

    Computer Security Team

    2012-01-01

    Do you recall our article about copyright violation in the last issue of the CERN Bulletin, “Music, videos and the risk for CERN”? Now let’s be more precise. “Violating copyright” not only means the illegal download of music and videos, it also applies to software packages and applications.   Users must respect proprietary rights in compliance with the CERN Computing Rules (OC5). Not having legitimately obtained a program or the required licenses to run that software is not a minor offense. It violates CERN rules and puts the Organization at risk! Vendors deserve credit and compensation. Therefore, make sure that you have the right to use their software. In other words, you have bought the software via legitimate channels and use a valid and honestly obtained license. This also applies to “Shareware” and software under open licenses, which might also come with a cost. Usually, only “Freeware” is complete...

  16. Sub-Millimeter T2 Weighted fMRI at 7 T: Comparison of 3D-GRASE and 2D SE-EPI

    Directory of Open Access Journals (Sweden)

    Valentin G. Kemper

    2015-05-01

    Full Text Available Functional magnetic resonance imaging (fMRI allows studying human brain function non-invasively up to the spatial resolution of cortical columns and layers. Most fMRI acquisitions rely on the blood oxygenation level dependent (BOLD contrast employing T2* weighted 2D multi-slice echo-planar imaging (EPI. At ultra-high magnetic field (i.e. 7 T and above, it has been shown experimentally and by simulation, that T2 weighted acquisitions yield a signal that is spatially more specific to the site of neuronal activity at the cost of functional sensitivity. This study compared two T2 weighted imaging sequences, inner-volume 3D Gradient-and-Spin-Echo (3D-GRASE and 2D Spin-Echo EPI (SE-EPI, with evaluation of their imaging point-spread function, functional specificity, and functional sensitivity at sub-millimeter resolution. Simulations and measurements of the imaging point-spread function revealed that the strongest anisotropic blurring in 3D-GRASE (along the second phase-encoding direction was about 60 % higher than the strongest anisotropic blurring in 2D SE-EPI (along the phase-encoding direction In a visual paradigm, the BOLD sensitivity of 3D-GRASE was found to be superior due to its higher temporal signal-to-noise ratio. High resolution cortical depth profiles suggested that the contrast mechanisms are similar between the two sequences, however, 2D SE-EPI had a higher surface bias owing to the higher T2* contribution of the longer in-plane EPI echo-train for full field of view compared to the reduced field of view of zoomed 3D-GRASE.

  17. The EpiOcular Eye Irritation Test (EIT) for hazard identification and labelling of eye irritating chemicals: protocol optimisation for solid materials and the results after extended shipment.

    Science.gov (United States)

    Kaluzhny, Yulia; Kandárová, Helena; Handa, Yuki; DeLuca, Jane; Truong, Thoa; Hunter, Amy; Kearney, Paul; d'Argembeau-Thornton, Laurence; Klausner, Mitchell

    2015-05-01

    The 7th Amendment to the EU Cosmetics Directive and the EU REACH Regulation have reinforced the need for in vitro ocular test methods. Validated in vitro ocular toxicity tests that can predict the human response to chemicals, cosmetics and other consumer products are required for the safety assessment of materials that intentionally, or inadvertently, come into contact with the eye. The EpiOcular Eye Irritation Test (EIT), which uses the normal human cell-based EpiOcular™ tissue model, was developed to address this need. The EpiOcular-EIT is able to discriminate, with high sensitivity and accuracy, between ocular irritant/corrosive materials and those that require no labelling. Although the original EpiOcular-EIT protocol was successfully pre-validated in an international, multicentre study sponsored by COLIPA (the predecessor to Cosmetics Europe), data from two larger studies (the EURL ECVAM-COLIPA validation study and an independent in-house validation at BASF SE) resulted in a sensitivity for the protocol for solids that was below the acceptance criteria set by the Validation Management Group (VMG) for eye irritation, and indicated the need for improvement of the assay's sensitivity for solids. By increasing the exposure time for solid materials from 90 minutes to 6 hours, the optimised EpiOcular-EIT protocol achieved 100% sensitivity, 68.4% specificity and 84.6% accuracy, thereby meeting all the acceptance criteria set by the VMG. In addition, to satisfy the needs of Japan and the Pacific region, the EpiOcular-EIT method was evaluated for its performance after extended shipment and storage of the tissues (4-5 days), and it was confirmed that the assay performs with similar levels of sensitivity, specificity and reproducibility in these circumstances. 2015 FRAME.

  18. Towards an Ontology of Software

    OpenAIRE

    Wang, Xiaowei

    2016-01-01

    Software is permeating every aspect of our personal and social life. And yet, the cluster of concepts around the notion of software, such as the notions of a software product, software requirements, software specifications, are still poorly understood with no consensus on the horizon. For many, software is just code, something intangible best defined in contrast with hardware, but it is not particularly illuminating. This erroneous notion, software is just code, presents both in the ontology ...

  19. LDUA software custodian's notebook

    International Nuclear Information System (INIS)

    Aftanas, B.L.

    1998-01-01

    This plan describes the activities to be performed and controls to be applied to the process of specifying, obtaining, and qualifying the control and data acquisition software for the Light Duty Utility Arm (LDUA) System. It serves the purpose of a software quality assurance plan, a verification and validation plan, and a configuration management plan. This plan applies to all software that is an integral part of the LDUA control and data acquisition system, that is, software that is installed in the computers that are part of the LDUA system as it is deployed in the field. This plan applies to the entire development process, including: requirements; design; implementation; and operations and maintenance. This plan does not apply to any software that is not integral with the LDUA system. This plan has-been prepared in accordance with WHC-CM-6-1 Engineering Practices, EP-2.1; WHC-CM-3-10 Software Practices; and WHC-CM-4-2, QR 19.0, Software Quality Assurance Requirements

  20. Software Formal Inspections Guidebook

    Science.gov (United States)

    1993-01-01

    The Software Formal Inspections Guidebook is designed to support the inspection process of software developed by and for NASA. This document provides information on how to implement a recommended and proven method for conducting formal inspections of NASA software. This Guidebook is a companion document to NASA Standard 2202-93, Software Formal Inspections Standard, approved April 1993, which provides the rules, procedures, and specific requirements for conducting software formal inspections. Application of the Formal Inspections Standard is optional to NASA program or project management. In cases where program or project management decide to use the formal inspections method, this Guidebook provides additional information on how to establish and implement the process. The goal of the formal inspections process as documented in the above-mentioned Standard and this Guidebook is to provide a framework and model for an inspection process that will enable the detection and elimination of defects as early as possible in the software life cycle. An ancillary aspect of the formal inspection process incorporates the collection and analysis of inspection data to effect continual improvement in the inspection process and the quality of the software subjected to the process.

  1. The STARLINK software collection

    Science.gov (United States)

    Penny, A. J.; Wallace, P. T.; Sherman, J. C.; Terret, D. L.

    1993-12-01

    A demonstration will be given of some recent Starlink software. STARLINK is: a network of computers used by UK astronomers; a collection of programs for the calibration and analysis of astronomical data; a team of people giving hardware, software and administrative support. The Starlink Project has been in operation since 1980 to provide UK astronomers with interactive image processing and data reduction facilities. There are now Starlink computer systems at 25 UK locations, serving about 1500 registered users. The Starlink software collection now has about 25 major packages covering a wide range of astronomical data reduction and analysis techniques, as well as many smaller programs and utilities. At the core of most of the packages is a common `software environment', which provides many of the functions which applications need and offers standardized methods of structuring and accessing data. The software environment simplifies programming and support, and makes it easy to use different packages for different stages of the data reduction. Users see a consistent style, and can mix applications without hitting problems of differing data formats. The Project group coordinates the writing and distribution of this software collection, which is Unix based. Outside the UK, Starlink is used at a large number of places, which range from installations at major UK telescopes, which are Starlink-compatible and managed like Starlink sites, to individuals who run only small parts of the Starlink software collection.

  2. Study of Info backup system of strategy management for coal enterprises

    Energy Technology Data Exchange (ETDEWEB)

    Han, K.; Dai, B.; Li, Q.; Shao, J. [China University of Mining and Technology, Xuzhou (China). College of Mineral and Energy Resources

    2001-09-01

    It is an application system which helps the determination, enforcement and control of the development strategy of a coal enterprise. This system, which is based on Delphi 5.0, is a Windows application and is bundled with some excellent software, such as 3D Studio Max, Autocad, PhotoShop, Gif Gear etc. It comprises of two subsystems, i.e., the information backup subsystem of strategy management and the control subsystem of strategy enforcement. This system can provide not only the effective information to the leaders or the managers, but also the timely and effective control in the whole course of strategy enforcement. 5 refs.,1 fig.

  3. Evidence synthesis software.

    Science.gov (United States)

    Park, Sophie Elizabeth; Thomas, James

    2018-06-07

    It can be challenging to decide which evidence synthesis software to choose when doing a systematic review. This article discusses some of the important questions to consider in relation to the chosen method and synthesis approach. Software can support researchers in a range of ways. Here, a range of review conditions and software solutions. For example, facilitating contemporaneous collaboration across time and geographical space; in-built bias assessment tools; and line-by-line coding for qualitative textual analysis. EPPI-Reviewer is a review software for research synthesis managed by the EPPI-centre, UCL Institute of Education. EPPI-Reviewer has text mining automation technologies. Version 5 supports data sharing and re-use across the systematic review community. Open source software will soon be released. EPPI-Centre will continue to offer the software as a cloud-based service. The software is offered via a subscription with a one-month (extendible) trial available and volume discounts for 'site licences'. It is free to use for Cochrane and Campbell reviews. The next EPPI-Reviewer version is being built in collaboration with National Institute for Health and Care Excellence using 'surveillance' of newly published research to support 'living' iterative reviews. This is achieved using a combination of machine learning and traditional information retrieval technologies to identify the type of research each new publication describes and determine its relevance for a particular review, domain or guideline. While the amount of available knowledge and research is constantly increasing, the ways in which software can support the focus and relevance of data identification are also developing fast. Software advances are maximising the opportunities for the production of relevant and timely reviews. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise

  4. Evaluation of a multiple spin- and gradient-echo (SAGE) EPI acquisition with SENSE acceleration: applications for perfusion imaging in and outside the brain.

    Science.gov (United States)

    Skinner, Jack T; Robison, Ryan K; Elder, Christopher P; Newton, Allen T; Damon, Bruce M; Quarles, C Chad

    2014-12-01

    Perfusion-based changes in MR signal intensity can occur in response to the introduction of exogenous contrast agents and endogenous tissue properties (e.g. blood oxygenation). MR measurements aimed at capturing these changes often implement single-shot echo planar imaging (ssEPI). In recent years ssEPI readouts have been combined with parallel imaging (PI) to allow fast dynamic multi-slice imaging as well as the incorporation of multiple echoes. A multiple spin- and gradient-echo (SAGE) EPI acquisition has recently been developed to allow measurement of transverse relaxation rate (R2 and R2(*)) changes in dynamic susceptibility contrast (DSC)-MRI experiments in the brain. With SAGE EPI, the use of PI can influence image quality, temporal resolution, and achievable echo times. The effect of PI on dynamic SAGE measurements, however, has not been evaluated. In this work, a SAGE EPI acquisition utilizing SENSE PI and partial Fourier (PF) acceleration was developed and evaluated. Voxel-wise measures of R2 and R2(*) in healthy brain were compared using SAGE EPI and conventional non-EPI multiple echo acquisitions with varying SENSE and PF acceleration. A conservative SENSE factor of 2 with PF factor of 0.73 was found to provide accurate measures of R2 and R2(*) in white (WM) (rR2=[0.55-0.79], rR2*=[0.47-0.71]) and gray (GM) matter (rR2=[0.26-0.59], rR2*=[0.39-0.74]) across subjects. The combined use of SENSE and PF allowed the first dynamic SAGE EPI measurements in muscle, with a SENSE factor of 3 and PF factor of 0.6 providing reliable relaxation rate estimates when compared to multi-echo methods. Application of the optimized SAGE protocol in DSC-MRI of high-grade glioma patients provided T1 leakage-corrected estimates of CBV and CBF as well as mean vessel diameter (mVD) and simultaneous measures of DCE-MRI parameters K(trans) and ve. Likewise, application of SAGE in a muscle reperfusion model allowed dynamic measures of R2', a parameter that has been shown to correlate

  5. Accuracy and precision of the CKD-EPI and MDRD predictive equations compared with glomerular filtration rate measured by inulin clearance in a Saudi population.

    Science.gov (United States)

    Al-Wakeel, Jamal Saleh

    2016-01-01

    Predictive equations for estimating glomerular filtration rate (GFR) in different clinical conditions should be validated by comparing with the measurement of GFR using inulin clearance, a highly accurate measure of GFR. Our aim was to validate the Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations by comparing it to the GFR measured using inulin clearance in chronic kidney disease (CKD) patients. Cross-sectional study performed in adult Saudi patients with CKD. King Saud University Affiliated Hospital, Riyadh, Saudi Arabia in 2014. We compared GFR measured by inulin clearance with the estimated GFR calculated using CKD-EPI and MDRD predictive formulas. Correlation, bias, precision and accuracy between the estimated GFR and inulin clearance. Comparisons were made in 31 participants (23 CKD and 8 transplanted), including 19 males (mean age 42.2 [15] years and weight 68.7 [18] kg). GFR using inulin was 51.54 (33.8) mL/min/1.73 m2 in comparison to inulin clearance, the GFR by the predictive equations was: CKD-EPI creatinine 52.6 (34.4) mL/ min/1.73 m2 (P=.490), CKD-EPI cystatin C 41.39 (30.30) mL/min/1.73 m2 (P=.002), CKD creatinine-cystatin C 45.03 (30.9) mL/min/1.73 m2 (P=.004) and MDRD GFR 48.35 (31.5) mL/min/1.73 m2 (P=.028) (statistical comparisons vs inulin). Bland-Altman plots demonstrated that GFR estimated by the CKD-EPI creatinine was the most accurate compared with inulin clearance, having a mean difference (estimated bias) and limits of agreement of -1.1 (15.6,-17.7). By comparison the mean differences for predictive equations were: CKD-EPI cystatin C 10.2 (43.7,-23.4), CKD creatinine-cystatin C 6.5 (29.3,-16.3) and MDRD 3.2 (18.3,-11.9). except for CKD-EPI creatinine, all of the equations underestimated GFR in comparison with inulin clearance. When compared with inulin clearance, the CKD-EPI creatinine equation is the most accurate, precise and least biased equation for estimation of GFR

  6. Other compounds isolated from Simira glaziovii and the {sup 1}H and {sup 13}C NMR chemical shift assignments of new 1-epi-castanopsol

    Energy Technology Data Exchange (ETDEWEB)

    Araujo, Marcelo F. de; Vieira, Ivo J. Curcino [Universidade Federal Rural do Rio de Janeiro, Seropedica, RJ (Brazil). Dept. de Quimica; Braz-Filho, Raimundo [Universidade Estadual do Norte Fluminense (UENF), Campos dos Goytacases, RJ (Brazil). Centro de Ciencias Tecnologicas. Lab. de Ciencias Quimicas; Carvalho, Mario G. de, E-mail: mgeraldo@ufrrj.br [Universidade Federal do Rio de Janeiro (NPPN/UFRJ), RJ (Brazil). Centro de Ciencias da Saude. Nucleo de Pesquisa em Produtos Naturais

    2012-07-01

    A new triterpene, 1-epi-castanopsol, besides eleven known compounds: sitosterol, stigmasterol, campesterol, lupeol, lupenone, simirane B, syringaresinol, scopoletin, isofraxidin, 6,7,8-trimethoxycoumarin and harman, were isolated from the wood of Simira glaziovii. The structures of the known compounds were defined by 1D, 2D {sup 1}H, {sup 13}C NMR spectra data analyses and comparison with literature data. The detailed spectral data analyses allowed the definition of the structure of the new 1-epi isomer of castanopsol and performance of {sup 1}H and {sup 13}C NMR chemical shift assignments. (author)

  7. Other compounds isolated from Simira glaziovii and the 1H and 13C NMR chemical shift assignments of new 1-epi-castanopsol

    International Nuclear Information System (INIS)

    Araujo, Marcelo F. de; Vieira, Ivo J. Curcino; Braz-Filho, Raimundo; Carvalho, Mario G. de

    2012-01-01

    A new triterpene, 1-epi-castanopsol, besides eleven known compounds: sitosterol, stigmasterol, campesterol, lupeol, lupenone, simirane B, syringaresinol, scopoletin, isofraxidin, 6,7,8-trimethoxycoumarin and harman, were isolated from the wood of Simira glaziovii. The structures of the known compounds were defined by 1D, 2D 1 H, 13 C NMR spectra data analyses and comparison with literature data. The detailed spectral data analyses allowed the definition of the structure of the new 1-epi isomer of castanopsol and performance of 1 H and 13 C NMR chemical shift assignments. (author)

  8. Decision making in family medicine: randomized trial of the effects of the InfoClinique and Trip database search engines.

    Science.gov (United States)

    Labrecque, Michel; Ratté, Stéphane; Frémont, Pierre; Cauchon, Michel; Ouellet, Jérôme; Hogg, William; McGowan, Jessie; Gagnon, Marie-Pierre; Njoya, Merlin; Légaré, France

    2013-10-01

    To compare the ability of users of 2 medical search engines, InfoClinique and the Trip database, to provide correct answers to clinical questions and to explore the perceived effects of the tools on the clinical decision-making process. Randomized trial. Three family medicine units of the family medicine program of the Faculty of Medicine at Laval University in Quebec city, Que. Fifteen second-year family medicine residents. Residents generated 30 structured questions about therapy or preventive treatment (2 questions per resident) based on clinical encounters. Using an Internet platform designed for the trial, each resident answered 20 of these questions (their own 2, plus 18 of the questions formulated by other residents, selected randomly) before and after searching for information with 1 of the 2 search engines. For each question, 5 residents were randomly assigned to begin their search with InfoClinique and 5 with the Trip database. The ability of residents to provide correct answers to clinical questions using the search engines, as determined by third-party evaluation. After answering each question, participants completed a questionnaire to assess their perception of the engine's effect on the decision-making process in clinical practice. Of 300 possible pairs of answers (1 answer before and 1 after the initial search), 254 (85%) were produced by 14 residents. Of these, 132 (52%) and 122 (48%) pairs of answers concerned questions that had been assigned an initial search with InfoClinique and the Trip database, respectively. Both engines produced an important and similar absolute increase in the proportion of correct answers after searching (26% to 62% for InfoClinique, for an increase of 36%; 24% to 63% for the Trip database, for an increase of 39%; P = .68). For all 30 clinical questions, at least 1 resident produced the correct answer after searching with either search engine. The mean (SD) time of the initial search for each question was 23.5 (7

  9. Beginning software engineering

    CERN Document Server

    Stephens, Rod

    2015-01-01

    Beginning Software Engineering demystifies the software engineering methodologies and techniques that professional developers use to design and build robust, efficient, and consistently reliable software. Free of jargon and assuming no previous programming, development, or management experience, this accessible guide explains important concepts and techniques that can be applied to any programming language. Each chapter ends with exercises that let you test your understanding and help you elaborate on the chapter's main concepts. Everything you need to understand waterfall, Sashimi, agile, RAD, Scrum, Kanban, Extreme Programming, and many other development models is inside!

  10. Software industrial flexible

    OpenAIRE

    Díaz Araya, Daniel; Muñoz, Leandro; Sirerol, Daniel; Oviedo, Sandra; Ibáñez, Francisco S.

    2012-01-01

    En este trabajo se pretende investigar y proponer técnicas, métodos y tecnologías que permitan el desarrollo de software flexible en ambientes industriales. El objetivo es generar métodos y técnicas para facilitar el desarrollo de software flexible en ambientes industriales. Las áreas de investigación son los sistemas de scheduling de producción, la generación de software para plataformas de hardware abiertas y la innovación.

  11. Thyroid uptake software

    International Nuclear Information System (INIS)

    Alonso, Dolores; Arista, Eduardo

    2003-01-01

    The DETEC-PC software was developed as a complement to a measurement system (hardware) able to perform Iodine Thyroid Uptake studies. The software was designed according to the principles of Object oriented programming using C++ language. The software automatically fixes spectrometric measurement parameters and besides patient measurement also performs statistical analysis of a batch of samples. It possesses a PARADOX database with all information of measured patients and a help system with the system options and medical concepts related to the thyroid uptake study

  12. Criteria for software modularization

    Science.gov (United States)

    Card, David N.; Page, Gerald T.; Mcgarry, Frank E.

    1985-01-01

    A central issue in programming practice involves determining the appropriate size and information content of a software module. This study attempted to determine the effectiveness of two widely used criteria for software modularization, strength and size, in reducing fault rate and development cost. Data from 453 FORTRAN modules developed by professional programmers were analyzed. The results indicated that module strength is a good criterion with respect to fault rate, whereas arbitrary module size limitations inhibit programmer productivity. This analysis is a first step toward defining empirically based standards for software modularization.

  13. Error Free Software

    Science.gov (United States)

    1985-01-01

    A mathematical theory for development of "higher order" software to catch computer mistakes resulted from a Johnson Space Center contract for Apollo spacecraft navigation. Two women who were involved in the project formed Higher Order Software, Inc. to develop and market the system of error analysis and correction. They designed software which is logically error-free, which, in one instance, was found to increase productivity by 600%. USE.IT defines its objectives using AXES -- a user can write in English and the system converts to computer languages. It is employed by several large corporations.

  14. Upgrade Software and Computing

    CERN Document Server

    The LHCb Collaboration, CERN

    2018-01-01

    This document reports the Research and Development activities that are carried out in the software and computing domains in view of the upgrade of the LHCb experiment. The implementation of a full software trigger implies major changes in the core software framework, in the event data model, and in the reconstruction algorithms. The increase of the data volumes for both real and simulated datasets requires a corresponding scaling of the distributed computing infrastructure. An implementation plan in both domains is presented, together with a risk assessment analysis.

  15. Global Software Engineering

    DEFF Research Database (Denmark)

    Ebert, Christof; Kuhrmann, Marco; Prikladnicki, Rafael

    2016-01-01

    SOFTWARE, LIKE ALL industry products, is the result of complex multinational supply chains with many partners from concept to development to production and maintenance. Global software engineering (GSE), IT outsourcing, and business process outsourcing during the past decade have showed growth...... rates of 10 to 20 percent per year. This instalment of Practitioner’s Digest summarizes experiences and guidance from industry to facilitate knowledge and technology transfer for GSE. It’s based on industry feedback from the annual IEEE International Conference on Global Software Engineering, which had...

  16. Software for microcircuit systems

    International Nuclear Information System (INIS)

    Kunz, P.F.

    1978-01-01

    Modern Large Scale Integration (LSI) microcircuits are meant to be programmed in order to control the function that they perform. In the previous paper the author has already discussed the basics of microprogramming and have studied in some detail two types of new microcircuits. In this paper, methods of developing software for these microcircuits are explored. This generally requires a package of support software in order to assemble the microprogram, and also some amount of support software to test the microprograms and to test the microprogrammed circuit itself. (Auth.)

  17. Guide to software export

    CERN Document Server

    Philips, Roger A

    2014-01-01

    An ideal reference source for CEOs, marketing and sales managers, sales consultants, and students of international marketing, Guide to Software Export provides a step-by-step approach to initiating or expanding international software sales. It teaches you how to examine critically your candidate product for exportability; how to find distributors, agents, and resellers abroad; how to identify the best distribution structure for export; and much, much more!Not content with providing just the guidelines for setting up, expanding, and managing your international sales channels, Guide to Software

  18. Software takes command

    CERN Document Server

    Manovich, Lev

    2013-01-01

    Software has replaced a diverse array of physical, mechanical, and electronic technologies used before 21st century to create, store, distribute and interact with cultural artifacts. It has become our interface to the world, to others, to our memory and our imagination - a universal language through which the world speaks, and a universal engine on which the world runs. What electricity and combustion engine were to the early 20th century, software is to the early 21st century. Offering the the first theoretical and historical account of software for media authoring and its effects on the prac

  19. Software quality assurance handbook

    Energy Technology Data Exchange (ETDEWEB)

    1990-09-01

    There are two important reasons for Software Quality Assurance (SQA) at Allied-Signal Inc., Kansas City Division (KCD): First, the benefits from SQA make good business sense. Second, the Department of Energy has requested SQA. This handbook is one of the first steps in a plant-wide implementation of Software Quality Assurance at KCD. The handbook has two main purposes. The first is to provide information that you will need to perform software quality assurance activities. The second is to provide a common thread to unify the approach to SQA at KCD. 2 figs.

  20. Sobre software libre

    OpenAIRE

    Matellán Olivera, Vicente; González Barahona, Jesús; Heras Quirós, Pedro de las; Robles Martínez, Gregorio

    2004-01-01

    220 p. "Sobre software libre" reune casi una treintena de ensayos sobre temas de candente actualidad relacionados con el software libre (del cual Linux es su ex- ponente más conocido). Los ensayos que el lector encontrará están divididos en bloques temáticos que van desde la propiedad intelectual o las cuestiones económicas y sociales de este modelo hasta su uso en la educación y las administraciones publicas, pasando por alguno que repasa la historia del software libre en l...

  1. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan.

    Science.gov (United States)

    Soofi, Sajid Bashir; Haq, Inam-Ul; Khan, M Imran; Siddiqui, Muhammad Bilal; Mirani, Mushtaq; Tahir, Rehman; Hussain, Imtiaz; Puri, Mahesh K; Suhag, Zamir Hussain; Khowaja, Asif R; Lasi, Abdul Razzaq; Clemens, John D; Favorov, Michael; Ochiai, R Leon; Bhutta, Zulfiqar A

    2012-01-06

    Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI) provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school enrolment is high, schools provide a cost effective opportunity for vaccination. Prior to start of a school-based typhoid vaccination program, interviews were conducted with staff of educational institutions in two townships of Karachi, Pakistan to collect baseline information about the school system and to plan a typhoid vaccination program. Data collection teams administered a structured questionnaire to all schools in the two townships. The administrative staff was requested information on school fee, class enrolment, past history of involvement and willingness of parents to participate in a vaccination campaign. A total of 304,836 students were enrolled in 1,096 public, private, and religious schools (Madrasahs) of the two towns. Five percent of schools refused to participate in the school census. Twenty-five percent of schools had a total enrolment of less than 100 students whereas 3% had more than 1,000 students. Health education programs were available in less than 8% of public schools, 17% of private schools, and 14% of Madrasahs. One-quarter of public schools, 41% of private schools, and 43% of Madrasahs had previously participated in a school-based vaccination campaign. The most common vaccination campaign in which schools participated was Polio eradication program. Cost of the vaccine, side effects, and parents' lack of information were highlighted as important limiting factors by school administration for school-based immunization programs. Permission from parents, appropriateness of vaccine-related information, and involvement of teachers were considered as important factors to improve participation. Health education programs are not part of the regular school curriculum

  2. Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan

    Directory of Open Access Journals (Sweden)

    Soofi Sajid

    2012-01-01

    Full Text Available Abstract Background Vaccines are the most effective public health intervention. Expanded Program on Immunization (EPI provides routine vaccination in developing countries. However, vaccines that cannot be given in EPI schedule such as typhoid fever vaccine need alternative venues. In areas where school enrolment is high, schools provide a cost effective opportunity for vaccination. Prior to start of a school-based typhoid vaccination program, interviews were conducted with staff of educational institutions in two townships of Karachi, Pakistan to collect baseline information about the school system and to plan a typhoid vaccination program. Data collection teams administered a structured questionnaire to all schools in the two townships. The administrative staff was requested information on school fee, class enrolment, past history of involvement and willingness of parents to participate in a vaccination campaign. Results A total of 304,836 students were enrolled in 1,096 public, private, and religious schools (Madrasahs of the two towns. Five percent of schools refused to participate in the school census. Twenty-five percent of schools had a total enrolment of less than 100 students whereas 3% had more than 1,000 students. Health education programs were available in less than 8% of public schools, 17% of private schools, and 14% of Madrasahs. One-quarter of public schools, 41% of private schools, and 43% of Madrasahs had previously participated in a school-based vaccination campaign. The most common vaccination campaign in which schools participated was Polio eradication program. Cost of the vaccine, side effects, and parents' lack of information were highlighted as important limiting factors by school administration for school-based immunization programs. Permission from parents, appropriateness of vaccine-related information, and involvement of teachers were considered as important factors to improve participation. Conclusions Health

  3. QUALITY MANAGEMENT OPERATION MECHANISMS FOR THE PROTECTION OF INFORMATION IN THE INFO-COMMUNICATION SYSTEMS

    Directory of Open Access Journals (Sweden)

    S. V. Belokurov

    2015-01-01

    Full Text Available The article presents the list of facilities and necessary procedures to protect against threats of violation of information availability in terms of exposure to malware in ICT systems and principles conceptual design of mechanisms, antivirus protection, implemented in the form of a component of a software complex for protection of information. This development allows us to formulate the principles of conceptual design of mechanisms, antivirus protection, implemented in the form of a component of a complex of software tools of information security. Special this valuable development for the implementation of procedures for the management of complex organizationaltechnical systems. Streamlining usually has one or any combination of the following objectives (attitudes: rationality, efficiency, improvement of the system. The aim of good governance (e.g. anti-malware is the preservation of the existing structure and system parameters under certain constraints (e.g., constraints on computing resources. If you cannot provide the management on a rational basis, it becomes necessary to change the parameters (parametric synthesis or search for and select the set of admissible structures effective on the criteria of structure (structural synthesis. Note that in this case we are talking about effectiveness for a given period of time, as social and scientific progress inevitably lead to a change of criteria effectiveness evaluation.

  4. Intellectual Property Protection of Software – At the Crossroads of Software Patents and Open Source Software

    OpenAIRE

    Tantarimäki, Maria

    2018-01-01

    The thesis considers the intellectual property protection of software in Europe and in the US, which is increasingly important subject as the world is globalizing and digitalizing. The special nature of software has challenges the intellectual property rights. The current protection of software is based on copyright protection but in this thesis, two other options are considered: software patents and open source software. Software patents provide strong protection for software whereas the pur...

  5. Center for Adaptive Optics | Software

    Science.gov (United States)

    Optics Software The Center for Adaptive Optics acts as a clearing house for distributing Software to Institutes it gives specialists in Adaptive Optics a place to distribute their software. All software is shared on an "as-is" basis and the users should consult with the software authors with any

  6. A concept of software testing for SMART MMIS software

    International Nuclear Information System (INIS)

    Seo, Yong Seok; Seong, Seung Hwan; Park, Keun Ok; Hur, Sub; Kim, Dong Hoon

    2001-01-01

    In order to achieve high quality of SMART MMIS software, the well-constructed software testing concept shall be required. This paper established software testing concept which is to be applied to SMART MMIS software, in terms of software testing organization, documentation. procedure, and methods. The software testing methods are classified into source code static analysis and dynamic testing. The software dynamic testing methods are discussed with two aspects: white-box and black-box testing. As software testing concept introduced in this paper is applied to the SMART MMIS software. the high quality of the software will be produced. In the future, software failure data will be collected through the construction of SMART MMIS prototyping facility which the software testing concept of this paper is applied to

  7. Computer Center: Software Review.

    Science.gov (United States)

    Duhrkopf, Richard, Ed.; Belshe, John F., Ed.

    1988-01-01

    Reviews a software package, "Mitosis-Meiosis," available for Apple II or IBM computers with colorgraphics capabilities. Describes the documentation, presentation and flexibility of the program. Rates the program based on graphics and usability in a biology classroom. (CW)

  8. Petroleum software profiles

    International Nuclear Information System (INIS)

    Anon.

    1996-01-01

    A profile of twenty-two software packages designed for petroleum exploration and production was provided. Some focussed on the oil and gas engineering industry, and others on mapping systems containing well history files and well data summaries. Still other programs provided accounting systems designed to address the complexities of the oil and gas industry. The software packages reviewed were developed by some of the best-known groups involved in software development for the oil and gas industry, including among others, Geoquest, the Can Tek Group, Applied Terravision Systems Inc., Neotechnology Consultants Ltd., (12) OGCI Software Inc., Oracle Energy, Production Revenue Information Systems Management, Virtual Computing Services Ltd., and geoLogic Systems Ltd

  9. Next Generation Software Development

    National Research Council Canada - National Science Library

    Manna, Zohar

    2005-01-01

    Under this grant we have studied the development of a scientifically sound basis for software development that builds on widely used pragmatic methods but is firmly grounded in well-established formal...

  10. Managing Distributed Software Projects

    DEFF Research Database (Denmark)

    Persson, John Stouby

    Increasingly, software projects are becoming geographically distributed, with limited face-toface interaction between participants. These projects face particular challenges that need careful managerial attention. This PhD study reports on how we can understand and support the management...... of distributed software projects, based on a literature study and a case study. The main emphasis of the literature study was on how to support the management of distributed software projects, but also contributed to an understanding of these projects. The main emphasis of the case study was on how to understand...... the management of distributed software projects, but also contributed to supporting the management of these projects. The literature study integrates what we know about risks and risk-resolution techniques, into a framework for managing risks in distributed contexts. This framework was developed iteratively...

  11. eSoftwareList

    Data.gov (United States)

    US Agency for International Development — USAID Software Database reporting tool created in Oracle Application Express (APEX). This version provides read only access to a database view of the JIRA SAR...

  12. Software didattico: integrazione scolastica

    Directory of Open Access Journals (Sweden)

    Lucia Ferlino

    1996-01-01

    Full Text Available Discussion of the use of educational software for school integration. Requires being aware of its potential effectiveness and know that it also lies in the choice of functional products.

  13. Core Flight Software

    Data.gov (United States)

    National Aeronautics and Space Administration — The AES Core Flight Software (CFS) project purpose is to analyze applicability, and evolve and extend the reusability of the CFS system originally developed by...

  14. Tier2 Submit Software

    Science.gov (United States)

    Download this tool for Windows or Mac, which helps facilities prepare a Tier II electronic chemical inventory report. The data can also be exported into the CAMEOfm (Computer-Aided Management of Emergency Operations) emergency planning software.

  15. SEER Data & Software

    Science.gov (United States)

    Options for accessing datasets for incidence, mortality, county populations, standard populations, expected survival, and SEER-linked and specialized data. Plus variable definitions, documentation for reporting and using datasets, statistical software (SEER*Stat), and observational research resources.

  16. Managing Software Process Evolution

    DEFF Research Database (Denmark)

    This book focuses on the design, development, management, governance and application of evolving software processes that are aligned with changing business objectives, such as expansion to new domains or shifting to global production. In the context of an evolving business world, it examines...... the complete software process lifecycle, from the initial definition of a product to its systematic improvement. In doing so, it addresses difficult problems, such as how to implement processes in highly regulated domains or where to find a suitable notation system for documenting processes, and provides...... essential insights and tips to help readers manage process evolutions. And last but not least, it provides a wealth of examples and cases on how to deal with software evolution in practice. Reflecting these topics, the book is divided into three parts. Part 1 focuses on software business transformation...

  17. Software for nuclear spectrometry

    International Nuclear Information System (INIS)

    1998-10-01

    The Advisory Group Meeting (AGM) on Software for Nuclear Spectrometry was dedicated to review the present status of software for nuclear spectrometry and to advise on future activities in this field. Because similar AGM and consultant's meetings had been held in the past; together with an attempt to get more streamlined, this AGM was devoted to the specific field of software for gamma ray spectrometry. Nevertheless, many of the issues discussed and the recommendations made are of general concern for any software on nuclear spectrometry. The report is organized by sections. The 'Summary' gives conclusions and recommendations adopted at the AGM. These conclusions and recommendations resulted from the discussions held during and after presentations of the scientific and technical papers. These papers are reported here in their integral form in the following Sections

  18. Software for radiation protection

    International Nuclear Information System (INIS)

    Graffunder, H.

    2002-01-01

    The software products presented are universally usable programs for radiation protection. The systems were designed in order to establish a comprehensive database specific to radiation protection and, on this basis, model in programs subjects of radiation protection. Development initially focused on the creation of the database. Each software product was to access the same nuclide-specific data; input errors and differences in spelling were to be excluded from the outset. This makes the products more compatible with each other and able to exchange data among each other. The software products are modular in design. Functions recurring in radiation protection are always treated the same way in different programs, and also represented the same way on the program surface. The recognition effect makes it easy for users to familiarize with the products quickly. All software products are written in German and are tailored to the administrative needs and codes and regulations in Germany and in Switzerland. (orig.) [de

  19. ITSY Handheld Software Radio

    National Research Council Canada - National Science Library

    Bose, Vanu

    2001-01-01

    .... A handheld software radio platform would enable the construction of devices that could inter-operate with multiple legacy systems, download new waveforms and be used to construct adhoc networks...

  20. Error-Free Software

    Science.gov (United States)

    1989-01-01

    001 is an integrated tool suited for automatically developing ultra reliable models, simulations and software systems. Developed and marketed by Hamilton Technologies, Inc. (HTI), it has been applied in engineering, manufacturing, banking and software tools development. The software provides the ability to simplify the complex. A system developed with 001 can be a prototype or fully developed with production quality code. It is free of interface errors, consistent, logically complete and has no data or control flow errors. Systems can be designed, developed and maintained with maximum productivity. Margaret Hamilton, President of Hamilton Technologies, also directed the research and development of USE.IT, an earlier product which was the first computer aided software engineering product in the industry to concentrate on automatically supporting the development of an ultrareliable system throughout its life cycle. Both products originated in NASA technology developed under a Johnson Space Center contract.

  1. MARS software package status

    International Nuclear Information System (INIS)

    Azhgirej, I.L.; Talanov, V.V.

    2000-01-01

    The MARS software package is intended for simulating the nuclear-electromagnetic cascades and the secondary neutrons and muons transport in the heterogeneous medium of arbitrary complexity in the magnetic fields presence. The inclusive approach to describing the particle production in the nuclear and electromagnetic interactions and by the unstable particles decay is realized in the package. The MARS software package was actively applied for solving various radiation physical problems [ru

  2. MAGIC user's group software

    International Nuclear Information System (INIS)

    Warren, G.; Ludeking, L.; McDonald, J.; Nguyen, K.; Goplen, B.

    1990-01-01

    The MAGIC User's Group has been established to facilitate the use of electromagnetic particle-in-cell software by universities, government agencies, and industrial firms. The software consists of a series of independent executables that are capable of inter-communication. MAGIC, SOS, μ SOS are used to perform electromagnetic simulations while POSTER is used to provide post-processing capabilities. Each is described in the paper. Use of the codes for Klystrode simulation is discussed

  3. Global software development

    DEFF Research Database (Denmark)

    Matthiesen, Stina

    2016-01-01

    This overview presents the mid stages of my doctoral research-based on ethnographic work conducted in IT companies in India and in Denmark-on collaborative work within global software development (GSD). In the following I briefly introduce how this research seeks to spark a debate in CSCW...... by challenging contemporary ideals about software development outsourcing through the exploration of the multiplicities and asymmetric dynamics inherent in the collaborative work of GSD....

  4. Principles of Antifragile Software

    OpenAIRE

    Monperrus, Martin

    2014-01-01

    The goal of this paper is to study and define the concept of "antifragile software". For this, I start from Taleb's statement that antifragile systems love errors, and discuss whether traditional software dependability fits into this class. The answer is somewhat negative, although adaptive fault tolerance is antifragile: the system learns something when an error happens, and always imrpoves. Automatic runtime bug fixing is changing the code in response to errors, fault injection in productio...

  5. Software product quality measurement

    OpenAIRE

    Godliauskas, Eimantas

    2016-01-01

    This paper analyses Ruby product quality measures, suggesting three new measures for Ruby product quality measurement tool Rubocop to measure Ruby product quality characteristics defined in ISO 2502n standard series. This paper consists of four main chapters. The first chapter gives a brief view of software product quality and software product quality measurement. The second chapter analyses object oriented quality measures. The third chapter gives a brief view of the most popular Ruby qualit...

  6. Application of EPI diffusion-weighted and Gd-DTPA T2* perfusion imaging in the diagnosis of brain ischemia

    International Nuclear Information System (INIS)

    Han Hongbin; Xie Jingxia

    1998-01-01

    Purpose: To study the MR and CT appearances of brain ischemia on diffusion-weighted imaging (DWI) and evaluate the role of EPI ADC-map, DWI and T 2 * perfusion imaging in acute stroke. Methods: DWI or ADC-map and routine T 1 WI and T 2 WI were performed in 36 patients with stroke (the time after onset of stroke: 2 hours - 2 months). Among them, 12 cases had perfusion imaging simultaneously. Results: Gd-DTPA T 2 * perfusion imaging demonstrated decrease of rrCBV and rrCBF in 10 cases; identical in 1 case and increase in 1 case. The mean transit time in the diseased area was longer than that of the contralateral corresponding region (paired t test: P 2 * perfusion imaging can demonstrate the decrease and restoration of CBF in the brain ischemic regions. DWI and ADC-map are highly valuable in the early diagnosis and monitoring the development of brain ischemic disease

  7. Divergent Total Syntheses of (-)-Huperzine Q, (+)-Lycopladine B, (+)-Lycopladine C, and (-)-4-epi-Lycopladine D.

    Science.gov (United States)

    Hong, Benke; Hu, Dachao; Wu, Jinbao; Zhang, Jing; Li, Houhua; Pan, Yingming; Lei, Xiaoguang

    2017-07-04

    We report herein our synthetic efforts towards the divergent syntheses of (-)-huperzine Q (1), (+)-lycopladine B (2), (+)-lycopladine C (3), and (-)-lycopladine D (4). The 10-step total synthesis of (-)-huperzine Q (1) and the first total syntheses of (+)-lycopladines B (2) and C (3) were accomplished through a series of cascade reactions. Our approach involved a Michael addition/aldol/intramolecular C-alkylation sequence to forge the 6/9 spirocycle ring, and this was followed by an ethylene-accelerated carbonyl-olefin metathesis to construct the common 6/5/9 ring system. Finally, late-stage enamine bromofunctionalization enabled us to access (-)-huperzine Q (1), (+)-lycopladine B (2), and (+)-lycopladine C (3), and a tandem C4-epimerization/retro-Claisen condensation furnished (-)-4-epi-lycopladine D (63). © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

  8. Investigation of nanocrystalline Epi-Si/γ-Al2O3 heterostructure deposited on Si substrate by spectroscopic ellipsometry

    International Nuclear Information System (INIS)

    Khatun, Mosammat Halima; Shahjahan, Mohammad; Ito, Ryoki; Sawada, Kazuaki; Ishida, Makoto

    2006-01-01

    In this work, micro-structural and interfacial studies of the epi-Si/γ-Al 2 O 3 heterostructure were undertaken by spectroscopic ellipsometry, and compared with the results of atomic force microscopy and X-ray photoelectron spectroscopy. The experimental ellipsometric data were fitted with the theoretical calculations using effective medium approximation for each layer of the structure. It was observed that the epitaxial silicon layer consists of a fraction of amorphous Si and crystalline Si. The percentage of amorphous silicon increases with the decrease of deposition temperature and with the increase of the deposition rate. The γ-Al 2 O 3 layer produces a hydrostatic pressure on the Si substrate and the amount of hydrostatic pressure was measured to be 8 x 10 9 dyn/cm 2

  9. Locating qualitative studies in dementia on MEDLINE, EMBASE, CINAHL, and PsycINFO: A comparison of search strategies.

    Science.gov (United States)

    Rogers, Morwenna; Bethel, Alison; Abbott, Rebecca

    2017-10-28

    Qualitative research in dementia improves understanding of the experience of people affected by dementia. Searching databases for qualitative studies is problematic. Qualitative-specific search strategies might help with locating studies. To examine the effectiveness (sensitivity and precision) of 5 qualitative strategies on locating qualitative research studies in dementia in 4 major databases (MEDLINE, EMBASE, PsycINFO, and CINAHL). Qualitative dementia studies were checked for inclusion on MEDLINE, EMBASE, PsycINFO, and CINAHL. Five qualitative search strategies (subject headings, simple free-text terms, complex free-text terms, and 2 broad-based strategies) were tested for study retrieval. Specificity, precision and number needed to read were calculated. Two hundred fourteen qualitative studies in dementia were included. PsycINFO and CINAHL held the most qualitative studies out the 4 databases studied (N = 171 and 166, respectively) and both held unique records (N = 14 and 7, respectively). The controlled vocabulary strategy in CINAHL returned 96% (N = 192) of studies held; by contrast, controlled vocabulary in PsycINFO returned 7% (N = 13) of studies held. The broad-based strategies returned more studies (93-99%) than the other free-text strategies (22-82%). Precision ranged from 0.061 to 0.004 resulting in a number needed to read to obtain 1 relevant study ranging from 16 (simple free-text search in CINAHL) to 239 (broad-based search in EMBASE). Qualitative search strategies using 3 broad terms were more sensitive than long complex searches. The controlled vocabulary for qualitative research in CINAHL was particularly effective. Furthermore, results indicate that MEDLINE and EMBASE offer little benefit for locating qualitative dementia research if CINAHL and PSYCINFO are also searched. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Modeling of Flood Mitigation Structures for Sarawak River Sub-basin Using Info Works River Simulation (RS)

    OpenAIRE

    Rosmina Bustami; Charles Bong; Darrien Mah; Afnie Hamzah; Marina Patrick

    2009-01-01

    The distressing flood scenarios that occur in recent years at the surrounding areas of Sarawak River have left damages of properties and indirectly caused disruptions of productive activities. This study is meant to reconstruct a 100-year flood event that took place in this river basin. Sarawak River Subbasin was chosen and modeled using the one-dimensional hydrodynamic modeling approach using InfoWorks River Simulation (RS), in combination with Geographical Information S...

  11. 2018-03-21T13:09:49Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    Abdu, SB Hassan, MR Adamu, HY Yashim, SM Oketona, GF Buck, digestibility, Gmelina arborea, maize cobs, red Sokoto bucks An experiment was conducted to ... info:eu-repo/semantics/publishedVersion Peer-reviewed Article application/pdf https://www.ajol.info/index.php/tjas/article/view/94039 Nigerian Journal of ...

  12. 2018-05-11T19:26:48Z https://www.ajol.info/index.php/all/oai oai:ojs ...

    African Journals Online (AJOL)

    2018-05-11T19:26:48Z https://www.ajol.info/index.php/all/oai ... standards and confidentiality of HIV/AIDS status in the workplace — a South African case ... Article application/pdf https://www.ajol.info/index.php/ajar/article/view/7294 African ...

  13. Süntaktiline info sõnastikus : probleeme ja väljavaateid / Margit Langemets, Merike Mägedi, Ülle Viks

    Index Scriptorium Estoniae

    Langemets, Margit, 1961-

    2005-01-01

    Süntaktilise info esitusest elektroonilistes sõnastikes ja suurtes leksikaalsetes andmebaasides. Süntaktilise info valikukriteeriumidest ja esitusviisidest Eesti Keele Instituudi uute sõnastikuprojektide, ennekõike eesti-X-keele sõnastiku tarvis. Andmetega autorite kohta

  14. Aktsionäri infoõigus : [bakalaureusetöö] / Henri Parisalu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Andres Vutt

    Index Scriptorium Estoniae

    Parisalu, Henri

    2009-01-01

    Aktsionäri infoõiguse eesmärkidest ja funktsioonidest, olemusest ja sisust mittebörsiühingutes ning börsiühingutes, siseriiklike ja rahvusvaheliste organisatsioonide mõjust aktsionäri infoõigusele

  15. [Bibliometric analysis of IBERPOC and EPI-SCAN studies. Contribution of the smoking variable on the iberpoc study].

    Science.gov (United States)

    de Granda-Orive, J I; Alonso-Arroyo, A; López-Padilla, D; Segrelles-Calvo, G; Jiménez-Ruiz, C A; Solano-Reina, S

    2018-03-01

    The aim of this study was to perform a bibliometric analysis of EPI-SCAN and IBERPOC studies using the Science Citation Index and Scopus databases, and to determine the overall impact with the impact of smoking on IBERPOC as a secondary objective. A general searching was conducted in Science Citation Index-Expanded through the Web of Science (WoS) (Thomson Reuters) platform and Scopus on 23 March 2015. The search strategy included the terms "iberpoc" OR "episcan" was performed on 15 October 2015. A total of 24 publications were obtained; 13 from IBERPOC study (9 on "COPD" and 4 for "tobacco"), with 11 from the EPI-SCAN (All COPD) study. A total of 841 WoS citations were obtained (445 IBERPOC [99 of tobacco]), and 1,442 from Scopus (963 IBERPOC [144 tobacco]). The theme "tobacco" contributed with 22.24% and 14.95% of total citations in WoS and Scopus, respectively to the IBERPOC study. It was found that Scopus citations were newer, and a similar impact from both WoS studies was detected, although the IBERPOC impact was greater in Scopus. Collaborative networks of institutions and authors of both studies were identified. There is an important productivity and impact of both studies. Scopus citations are newer than those in WoS. The "tobacco" variable added IBERPOC impact and visibility. There was high density, accessibility, and cohesion in collaborative networks of both studies. Copyright © 2017 Sociedad Española de Médicos de Atención Primaria (SEMERGEN). Publicado por Elsevier España, S.L.U. All rights reserved.

  16. Does skeletal muscle have an 'epi'-memory? The role of epigenetics in nutritional programming, metabolic disease, aging and exercise.

    Science.gov (United States)

    Sharples, Adam P; Stewart, Claire E; Seaborne, Robert A

    2016-08-01

    Skeletal muscle mass, quality and adaptability are fundamental in promoting muscle performance, maintaining metabolic function and supporting longevity and healthspan. Skeletal muscle is programmable and can 'remember' early-life metabolic stimuli affecting its function in adult life. In this review, the authors pose the question as to whether skeletal muscle has an 'epi'-memory? Following an initial encounter with an environmental stimulus, we discuss the underlying molecular and epigenetic mechanisms enabling skeletal muscle to adapt, should it re-encounter the stimulus in later life. We also define skeletal muscle memory and outline the scientific literature contributing to this field. Furthermore, we review the evidence for early-life nutrient stress and low birth weight in animals and human cohort studies, respectively, and discuss the underlying molecular mechanisms culminating in skeletal muscle dysfunction, metabolic disease and loss of skeletal muscle mass across the lifespan. We also summarize and discuss studies that isolate muscle stem cells from different environmental niches in vivo (physically active, diabetic, cachectic, aged) and how they reportedly remember this environment once isolated in vitro. Finally, we will outline the molecular and epigenetic mechanisms underlying skeletal muscle memory and review the epigenetic regulation of exercise-induced skeletal muscle adaptation, highlighting exercise interventions as suitable models to investigate skeletal muscle memory in humans. We believe that understanding the 'epi'-memory of skeletal muscle will enable the next generation of targeted therapies to promote muscle growth and reduce muscle loss to enable healthy aging. © 2016 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd.

  17. Examining software complexity and quality for scientific software

    International Nuclear Information System (INIS)

    Kelly, D.; Shepard, T.

    2005-01-01

    Research has not found a simple relationship between software complexity and software quality, and particularly no relationship between commonly used software complexity metrics and the occurrence of software faults. A study with an example of scientific software from the nuclear power industry illustrates the importance of addressing cognitive complexity, the complexity related to understanding the intellectual content of the software. Simple practices such as aptly-named variables contributes more to high quality software than limiting code sizes. This paper examines the research into complexity and quality and reports on a longitudinal study using the example of nuclear software. (author)

  18. Computing and software

    Directory of Open Access Journals (Sweden)

    White, G. C.

    2004-06-01

    Full Text Available The reality is that the statistical methods used for analysis of data depend upon the availability of software. Analysis of marked animal data is no different than the rest of the statistical field. The methods used for analysis are those that are available in reliable software packages. Thus, the critical importance of having reliable, up–to–date software available to biologists is obvious. Statisticians have continued to develop more robust models, ever expanding the suite of potential analysis methods available. But without software to implement these newer methods, they will languish in the abstract, and not be applied to the problems deserving them. In the Computers and Software Session, two new software packages are described, a comparison of implementation of methods for the estimation of nest survival is provided, and a more speculative paper about how the next generation of software might be structured is presented. Rotella et al. (2004 compare nest survival estimation with different software packages: SAS logistic regression, SAS non–linear mixed models, and Program MARK. Nests are assumed to be visited at various, possibly infrequent, intervals. All of the approaches described compute nest survival with the same likelihood, and require that the age of the nest is known to account for nests that eventually hatch. However, each approach offers advantages and disadvantages, explored by Rotella et al. (2004. Efford et al. (2004 present a new software package called DENSITY. The package computes population abundance and density from trapping arrays and other detection methods with a new and unique approach. DENSITY represents the first major addition to the analysis of trapping arrays in 20 years. Barker & White (2004 discuss how existing software such as Program MARK require that each new model’s likelihood must be programmed specifically for that model. They wishfully think that future software might allow the user to combine

  19. Software Engineering Reviews and Audits

    CERN Document Server

    Summers, Boyd L

    2011-01-01

    Accurate software engineering reviews and audits have become essential to the success of software companies and military and aerospace programs. These reviews and audits define the framework and specific requirements for verifying software development efforts. Authored by an industry professional with three decades of experience, Software Engineering Reviews and Audits offers authoritative guidance for conducting and performing software first article inspections, and functional and physical configuration software audits. It prepares readers to answer common questions for conducting and perform

  20. Business Management Software Axolon ERP

    OpenAIRE

    Axolon ERP Solution

    2018-01-01

    Axolon ERP a Business Management Software www.axolonerp.com by Micromind is a comprehensive business management software solution for businesses. We deliver Business Management Software Dubai in UAE, GCC Countries and products also include ERP Software Dubai. HR & Payroll, Inventory Software, Project Management, Software Development, Solutions and Services in Dubai, UAE for small and medium sized Enterprises (SME) in the middle east with a easy-to-use, secure and efficient business management...

  1. Time efficiency and diagnostic accuracy of new automated myocardial perfusion analysis software in 320-row CT cardiac imaging

    Energy Technology Data Exchange (ETDEWEB)

    Rief, Matthias; Stenzei, Fabian; Kranz, Anisha; Schlattmann, Peter; Dewey, Marc [Dept. of Radiology, Charite - Universiteitsmedizin Berlin, Berlin (Greece)

    2013-01-15

    We aimed to evaluate the time efficiency and diagnostic accuracy of automated myocardial computed tomography perfusion (CTP) image analysis software. 320-row CTP was performed in 30 patients, and analyses were conducted independently by three different blinded readers by the use of two recent software releases (version 4.6 and novel version 4.71GR001, Toshiba, Tokyo, Japan). Analysis times were compared, and automated epi- and endocardial contour detection was subjectively rated in five categories (excellent, good, fair, poor and very poor). As semi-quantitative perfusion parameters, myocardial attenuation and transmural perfusion ratio (TPR) were calculated for each myocardial segment and agreement was tested by using the intraclass correlation coefficient (ICC). Conventional coronary angiography served as reference standard. The analysis time was significantly reduced with the novel automated software version as compared with the former release (Reader 1: 43:08 ± 11:39 min vs. 09:47 ± 04:51 min, Reader 2: 42:07 ± 06:44 min vs. 09:42 ± 02:50 min and Reader 3: 21:38 ± 3:44 min vs. 07:34 ± 02:12 min; p < 0.001 for all). Epi- and endocardial contour detection for the novel software was rated to be significantly better (p < 0.001) than with the former software. ICCs demonstrated strong agreement (≥ 0.75) for myocardial attenuation in 93% and for TPR in 82%. Diagnostic accuracy for the two software versions was not significantly different (p 0.169) as compared with conventional coronary angiography. The novel automated CTP analysis software offers enhanced time efficiency with an improvement by a factor of about four, while maintaining diagnostic accuracy.

  2. Investigation of a 6-MSA Synthase Gene Cluster in Aspergillus aculeatus Reveals 6-MSA-derived Aculinic Acid, Aculins A-B and Epi-Aculin A

    DEFF Research Database (Denmark)

    Petersen, Lene Maj; Holm, Dorte Koefoed; Gotfredsen, Charlotte Held

    2015-01-01

    further incorporates into three compounds that we name aculins A and B, and epi-aculin A, described here for the first time. Based on NMR data and bioinformatic studies we propose the structures of the compounds as well as a biosynthetic pathway leading to formation of aculins from 6-MSA....

  3. Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs.

    Directory of Open Access Journals (Sweden)

    Masataka Hirasaki

    Full Text Available Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs. Epiblast stem cells (EpiSCs are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.

  4. Isolation of Notoamide S and Enantiomeric 6-epi-Stephacidin A from the Fungus Aspergillus amoenus: Biogenetic Implications

    DEFF Research Database (Denmark)

    Kato, Hikaru; Nakahara, Takashi; Sugimoto, Kayo

    2015-01-01

    Notoamide S has been hypothesized to be a key biosynthetic intermediate for characteristic metabolites stephacidin A, notoamide B, and versicolamide B in Aspergillus sp. but has not yet been isolated. The isolation of notoamide S and an enantiomeric mixture of 6-epi-stephacidin A enriched with th...

  5. Software FMEA analysis for safety-related application software

    International Nuclear Information System (INIS)

    Park, Gee-Yong; Kim, Dong Hoon; Lee, Dong Young

    2014-01-01

    Highlights: • We develop a modified FMEA analysis suited for applying to software architecture. • A template for failure modes on a specific software language is established. • A detailed-level software FMEA analysis on nuclear safety software is presented. - Abstract: A method of a software safety analysis is described in this paper for safety-related application software. The target software system is a software code installed at an Automatic Test and Interface Processor (ATIP) in a digital reactor protection system (DRPS). For the ATIP software safety analysis, at first, an overall safety or hazard analysis is performed over the software architecture and modules, and then a detailed safety analysis based on the software FMEA (Failure Modes and Effect Analysis) method is applied to the ATIP program. For an efficient analysis, the software FMEA analysis is carried out based on the so-called failure-mode template extracted from the function blocks used in the function block diagram (FBD) for the ATIP software. The software safety analysis by the software FMEA analysis, being applied to the ATIP software code, which has been integrated and passed through a very rigorous system test procedure, is proven to be able to provide very valuable results (i.e., software defects) that could not be identified during various system tests

  6. Plasma 3-Epi-25-Hydroxycholecalciferol Can Alter the Assessment of Vitamin D Status Using the Current Reference Ranges for Pregnant Women and Their Newborns.

    Science.gov (United States)

    Aghajafari, Fariba; Field, Catherine J; Rabi, Doreen; Kaplan, Bonnie J; Maggiore, Jack A; O'Beirne, Maeve; Hanley, David A; Eliasziw, Misha; Dewey, Deborah; Ross, Sue

    2016-01-01

    Vitamin D is critical for healthy pregnancies and normal fetal development. It is important to accurately ascertain vitamin D status in mothers and their newborns to establish the optimal vitamin D concentration during pregnancy. There are many different metabolites and epimers of vitamin D in peripheral blood and controversy as to the importance of epimers in estimating vitamin D status in maternal and infant health. We undertook this study to measure 25-hydroxyvitamin D metabolites and epimers and their relations in maternal and cord blood and to evaluate the impact of the inclusion of epimers on assessing vitamin D status. We performed a substudy in a longitudinal cohort of pregnant women and their infants in Alberta, Canada [APrON (Alberta Pregnancy Outcomes and Nutrition) Study]. Maternal and cord blood plasma collected at the time of newborn delivery was stored at -70°C until testing and assayed for 25-hydroxyergocalciferol [25(OH)D2], 25-hydroxycholecalciferol [25(OH)D3], and 3-epi-25-hydroxycholecalciferol [3-epi-25(OH)D3] by using LC-tandem mass spectrometry. The effect of 3-epi-25(OH)D3 on estimates of vitamin D adequacy was explored by using McNemar's chi-square test at both recommended thresholds of 50 and 75 nmol/L. Ninety-two pairs of maternal and cord blood samples were obtained. 3-Epi-25(OH)D3 was detected in all samples, comprising 6.0% and 7.8% of 25(OH)D3 in maternal and cord blood, respectively. Positive correlations were found between 25(OH)D3 and 3-epi-25(OH)D3 for both maternal and cord blood (maternal blood: r = 0.34, P = 0.01; cord blood: r = 0.44, P = 0.01). In addition, regression analysis showed a significant association between vitamin D supplementation and 3-epi-25(OH)D3 in maternal and cord blood (β: 0.423; 95% CI: 0.173, 0.672). When 3-epi-25(OH)D3 was not included in plasma vitamin D estimations, 38% of women and 80% of neonates were classified as having an insufficient concentration (pregnancy and infancy is imperative. © 2016

  7. The Ettention software package

    International Nuclear Information System (INIS)

    Dahmen, Tim; Marsalek, Lukas; Marniok, Nico; Turoňová, Beata; Bogachev, Sviatoslav; Trampert, Patrick; Nickels, Stefan; Slusallek, Philipp

    2016-01-01

    We present a novel software package for the problem “reconstruction from projections” in electron microscopy. The Ettention framework consists of a set of modular building-blocks for tomographic reconstruction algorithms. The well-known block iterative reconstruction method based on Kaczmarz algorithm is implemented using these building-blocks, including adaptations specific to electron tomography. Ettention simultaneously features (1) a modular, object-oriented software design, (2) optimized access to high-performance computing (HPC) platforms such as graphic processing units (GPU) or many-core architectures like Xeon Phi, and (3) accessibility to microscopy end-users via integration in the IMOD package and eTomo user interface. We also provide developers with a clean and well-structured application programming interface (API) that allows for extending the software easily and thus makes it an ideal platform for algorithmic research while hiding most of the technical details of high-performance computing. - Highlights: • Novel software package for “reconstruction from projections” in electron microscopy. • Support for high-resolution reconstructions on iterative reconstruction algorithms. • Support for CPU, GPU and Xeon Phi. • Integration in the IMOD software. • Platform for algorithm researchers: object oriented, modular design.

  8. Software reliability assessment

    International Nuclear Information System (INIS)

    Barnes, M.; Bradley, P.A.; Brewer, M.A.

    1994-01-01

    The increased usage and sophistication of computers applied to real time safety-related systems in the United Kingdom has spurred on the desire to provide a standard framework within which to assess dependable computing systems. Recent accidents and ensuing legislation have acted as a catalyst in this area. One particular aspect of dependable computing systems is that of software, which is usually designed to reduce risk at the system level, but which can increase risk if it is unreliable. Various organizations have recognized the problem of assessing the risk imposed to the system by unreliable software, and have taken initial steps to develop and use such assessment frameworks. This paper relates the approach of Consultancy Services of AEA Technology in developing a framework to assess the risk imposed by unreliable software. In addition, the paper discusses the experiences gained by Consultancy Services in applying the assessment framework to commercial and research projects. The framework is applicable to software used in safety applications, including proprietary software. Although the paper is written with Nuclear Reactor Safety applications in mind, the principles discussed can be applied to safety applications in all industries

  9. The Ettention software package

    Energy Technology Data Exchange (ETDEWEB)

    Dahmen, Tim, E-mail: Tim.Dahmen@dfki.de [German Research Center for Artificial Intelligence GmbH (DFKI), 66123 Saarbrücken (Germany); Saarland University, 66123 Saarbrücken (Germany); Marsalek, Lukas [Eyen SE, Na Nivách 1043/16, 141 00 Praha 4 (Czech Republic); Saarland University, 66123 Saarbrücken (Germany); Marniok, Nico [Saarland University, 66123 Saarbrücken (Germany); Turoňová, Beata [Saarland University, 66123 Saarbrücken (Germany); IMPRS-CS, Max-Planck Institute for Informatics, Campus E 1.4, 66123 Saarbrücken (Germany); Bogachev, Sviatoslav [Saarland University, 66123 Saarbrücken (Germany); Trampert, Patrick; Nickels, Stefan [German Research Center for Artificial Intelligence GmbH (DFKI), 66123 Saarbrücken (Germany); Slusallek, Philipp [German Research Center for Artificial Intelligence GmbH (DFKI), 66123 Saarbrücken (Germany); Saarland University, 66123 Saarbrücken (Germany)

    2016-02-15

    We present a novel software package for the problem “reconstruction from projections” in electron microscopy. The Ettention framework consists of a set of modular building-blocks for tomographic reconstruction algorithms. The well-known block iterative reconstruction method based on Kaczmarz algorithm is implemented using these building-blocks, including adaptations specific to electron tomography. Ettention simultaneously features (1) a modular, object-oriented software design, (2) optimized access to high-performance computing (HPC) platforms such as graphic processing units (GPU) or many-core architectures like Xeon Phi, and (3) accessibility to microscopy end-users via integration in the IMOD package and eTomo user interface. We also provide developers with a clean and well-structured application programming interface (API) that allows for extending the software easily and thus makes it an ideal platform for algorithmic research while hiding most of the technical details of high-performance computing. - Highlights: • Novel software package for “reconstruction from projections” in electron microscopy. • Support for high-resolution reconstructions on iterative reconstruction algorithms. • Support for CPU, GPU and Xeon Phi. • Integration in the IMOD software. • Platform for algorithm researchers: object oriented, modular design.

  10. Development of the software for the component reliability database system of Korean nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Han, Sang Hoon; Kim, Seung Hwan; Choi, Sun Young [Korea Atomic Energy Research Institute, Taejeon (Korea)

    2002-03-01

    A study was performed to develop the system for the component reliability database which consists of database system to store the reliability data and softwares to analyze the reliability data.This system is a part of KIND (Korea Information System for Nuclear Reliability Database).The MS-SQL database is used to stores the component population data, component maintenance history, and the results of reliability analysis. Two softwares were developed for the component reliability system. One is the KIND-InfoView for the data storing, retrieving and searching. The other is the KIND-CompRel for the statistical analysis of component reliability. 4 refs., 13 figs., 7 tabs. (Author)

  11. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 14

    Science.gov (United States)

    1996-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  12. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 15

    Science.gov (United States)

    1997-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  13. Software Engineering Laboratory Series: Collected Software Engineering Papers. Volume 13

    Science.gov (United States)

    1995-01-01

    The Software Engineering Laboratory (SEL) is an organization sponsored by NASA/GSFC and created to investigate the effectiveness of software engineering technologies when applied to the development of application software. The activities, findings, and recommendations of the SEL are recorded in the Software Engineering Laboratory Series, a continuing series of reports that includes this document.

  14. Software cost/resource modeling: Software quality tradeoff measurement

    Science.gov (United States)

    Lawler, R. W.

    1980-01-01

    A conceptual framework for treating software quality from a total system perspective is developed. Examples are given to show how system quality objectives may be allocated to hardware and software; to illustrate trades among quality factors, both hardware and software, to achieve system performance objectives; and to illustrate the impact of certain design choices on software functionality.

  15. Software architecture analysis tool : software architecture metrics collection

    NARCIS (Netherlands)

    Muskens, J.; Chaudron, M.R.V.; Westgeest, R.

    2002-01-01

    The Software Engineering discipline lacks the ability to evaluate software architectures. Here we describe a tool for software architecture analysis that is based on metrics. Metrics can be used to detect possible problems and bottlenecks in software architectures. Even though metrics do not give a

  16. Impact of Agile Software Development Model on Software Maintainability

    Science.gov (United States)

    Gawali, Ajay R.

    2012-01-01

    Software maintenance and support costs account for up to 60% of the overall software life cycle cost and often burdens tightly budgeted information technology (IT) organizations. Agile software development approach delivers business value early, but implications on software maintainability are still unknown. The purpose of this quantitative study…

  17. Belle II Software

    International Nuclear Information System (INIS)

    Kuhr, T; Ritter, M

    2016-01-01

    Belle II is a next generation B factory experiment that will collect 50 times more data than its predecessor, Belle. The higher luminosity at the SuperKEKB accelerator leads to higher background levels and requires a major upgrade of the detector. As a consequence, the simulation, reconstruction, and analysis software must also be upgraded substantially. Most of the software has been redesigned from scratch, taking into account the experience from Belle and other experiments and utilizing new technologies. The large amount of experimental and simulated data requires a high level of reliability and reproducibility, even in parallel environments. Several technologies, tools, and organizational measures are employed to evaluate and monitor the performance of the software during development. (paper)

  18. New Media as Software

    Directory of Open Access Journals (Sweden)

    Manuel Portela

    2014-03-01

    Full Text Available Review of Lev Manovich, Software Takes Command: Extending the Language of New Media. London: Bloomsbury, 2013, 358 pp. ISBN 978-1-6235-6817-7. In Lev Manovich’s most recent book, this programmatic interrogation of our medial condition leads to the following question: do media still exist after software? This is the question that triggers Manovich’s dialogue both with computing history and with theories of digital media of recent decades, including the extension of his own previous formulations in The Language of New Media, published in 2001, and which became a major reference work in the field. The subtitle of the new book points precisely to this critical revisiting of his earlier work in the context of ubiquitous computing and accelerated transcoding of social, cultural and artistic practices by software.

  19. LHCb software strategy

    CERN Document Server

    Van Herwijnen, Eric

    1998-01-01

    This document describes the software strategy of the LHCb experiment. The main objective is to reuse designs and code wherever possible; We will implement an architecturally driven design process; This architectural process will be implemented using Object Technology; We aim for platform indepence; try to take advantage of distributed computing and will use industry standards, commercial software and profit from HEP developments; We will implement a common software process and development environment. One of the major problems that we are immediately faced with is the conversion of our current code from Fortran into an Object Oriented language and the conversion of our current developers to Object technology. Some technical terms related to OO programming are defined in Annex A.1

  20. Test af Software

    DEFF Research Database (Denmark)

    Dette dokument udgør slutrapporten for netværkssamarbejdet ”Testnet”, som er udført i perioden 1.4.2006 til 31.12.2008. Netværket beskæftiger sig navnlig med emner inden for test af indlejret og teknisk software, men et antal eksempler på problemstillinger og løsninger forbundet med test af...... administrativ software indgår også. Rapporten er opdelt i følgende 3 dele: Overblik. Her giver vi et resumé af netværkets formål, aktiviteter og resultater. State of the art af software test ridses op. Vi omtaler, at CISS og netværket tager nye tiltag. Netværket. Formål, deltagere og behandlede emner på ti...

  1. ORNL's DCAL software package

    International Nuclear Information System (INIS)

    Eckerman, K.F.

    2007-01-01

    Oak Ridge National Laboratory has released its Dose and Risk Calculation software, DCAL. DCAL, developed with the support of the U.S. Environmental Protection Agency, consists of a series of computational modules, driven in either an interactive or a batch mode for computation of dose and risk coefficients from intakes of radionuclides or exposure to radionuclides in environmental media. The software package includes extensive libraries of biokinetic and dosimetric data that represent the current state of the art. The software has unique capability for addressing intakes of radionuclides by non-adults. DCAL runs as 32-bit extended DOS and console applications under Windows 98/NT/2000/XP. It is intended for users familiar with the basic elements of computational radiation dosimetry. Components of DCAL have been used to prepare U.S. Environmental Protection Agency's Federal Guidance Reports 12 and 13 and several publications of the International Commission on Radiological Protection. (author)

  2. Aircraft Design Software

    Science.gov (United States)

    1997-01-01

    Successful commercialization of the AirCraft SYNThesis (ACSYNT) tool has resulted in the creation of Phoenix Integration, Inc. ACSYNT has been exclusively licensed to the company, an outcome of a seven year, $3 million effort to provide unique software technology to a focused design engineering market. Ames Research Center formulated ACSYNT and in working with the Virginia Polytechnic Institute CAD Laboratory, began to design and code a computer-aided design for ACSYNT. Using a Joint Sponsored Research Agreement, Ames formed an industry-government-university alliance to improve and foster research and development for the software. As a result of the ACSYNT Institute, the software is becoming a predominant tool for aircraft conceptual design. ACSYNT has been successfully applied to high- speed civil transport configuration, subsonic transports, and supersonic fighters.

  3. Lecture 2: Software Security

    CERN Multimedia

    CERN. Geneva

    2013-01-01

    Computer security has been an increasing concern for IT professionals for a number of years, yet despite all the efforts, computer systems and networks remain highly vulnerable to attacks of different kinds. Design flaws and security bugs in the underlying software are among the main reasons for this. This lecture addresses the following question: how to create secure software? The lecture starts with a definition of computer security and an explanation of why it is so difficult to achieve. It then introduces the main security principles (like least-privilege, or defense-in-depth) and discusses security in different phases of the software development cycle. The emphasis is put on the implementation part: most common pitfalls and security bugs are listed, followed by advice on best practice for security development, testing and deployment. Sebastian Lopienski is CERN’s deputy Computer Security Officer. He works on security strategy and policies; offers internal consultancy and audit services; develops and ...

  4. The Effect of Software Reusability on Information Theory Based Software Metrics

    Science.gov (United States)

    1990-01-01

    of plans across programming languages and application areas, only a brief abstract treatment of non-contiguous "program parts" is mentioned in the...info->num = linenum; CA6 if(*info->text) W. if(find(linenum)) C.8 patchup(linenum, 1); /*fix up old line numbers*/ 107 C.9 if(*info->text) C-10 start

  5. Methods of Software Verification

    Directory of Open Access Journals (Sweden)

    R. E. Gurin

    2015-01-01

    Full Text Available This article is devoted to the problem of software verification (SW. Methods of software verification designed to check the software for compliance with the stated requirements such as correctness, system security and system adaptability to small changes in the environment, portability and compatibility, etc. These are various methods both by the operation process and by the way of achieving result. The article describes the static and dynamic methods of software verification and paid attention to the method of symbolic execution. In its review of static analysis are discussed and described the deductive method, and methods for testing the model. A relevant issue of the pros and cons of a particular method is emphasized. The article considers classification of test techniques for each method. In this paper we present and analyze the characteristics and mechanisms of the static analysis of dependencies, as well as their views, which can reduce the number of false positives in situations where the current state of the program combines two or more states obtained both in different paths of execution and in working with multiple object values. Dependences connect various types of software objects: single variables, the elements of composite variables (structure fields, array elements, the size of the heap areas, the length of lines, the number of initialized array elements in the verification code using static methods. The article pays attention to the identification of dependencies within the framework of the abstract interpretation, as well as gives an overview and analysis of the inference tools.Methods of dynamic analysis such as testing, monitoring and profiling are presented and analyzed. Also some kinds of tools are considered which can be applied to the software when using the methods of dynamic analysis. Based on the work a conclusion is drawn, which describes the most relevant problems of analysis techniques, methods of their solutions and

  6. Integration of PACS and HIS info the workflow of a nuclear medicine department. Experience in Regensburg

    International Nuclear Information System (INIS)

    Maenner, P.; Fuchs, E.; Marienhagen, J.; Schoenberger, J.; Eilles, C.; Tege, B.; Reicherzer, H.G.; Kurz, M.; Boerner, W.

    2006-01-01

    Aim: the development of new diagnostic techniques and the implementation of a modern quality control management system requires the continuous adaptation of existing data processing tools to the nuclear medicine diagnostic workflow. Furthermore, PACS connected to HIS facilitates and enhances the transfer of data and pictures, and satisfies the legal requirements for data retention as regulated by law. Therefore, the aim of this work is to present the architecture, structure and results of such a system newly installed in a department of nuclear medicine. Methods: initially, the nuclear medicine workflow was carefully analyzed and each step was correlated to the corresponding module. The standard SAP R/3 and IS-H / IS-H*med based software used for patient administration at the University of Regensburg Hospital was adapted to the needs of the Nuclear Medicine Department. The networking of the imaging systems was done by integration of a PACS. Finally, the PACS was connected to the HIS to allow the attachment of images to the medical report. Results, conclusion: by connecting the HIS to the nuclear medicine PACS, the workflow was significantly improved. The data management sequence starting at the reception desk, continuing through the nuclear medical examination, to the physician's final written and image report is clearly structured. Although high demands exist on technical support and administration the integration of PACS and HIS into the nuclear medicine workflow leads to enhanced efficiency and reduction in hospital costs. Patient and data management are considerably improved in this way. (orig.)

  7. A SOFTWARE RELIABILITY ESTIMATION METHOD TO NUCLEAR SAFETY SOFTWARE

    Directory of Open Access Journals (Sweden)

    GEE-YONG PARK

    2014-02-01

    Full Text Available A method for estimating software reliability for nuclear safety software is proposed in this paper. This method is based on the software reliability growth model (SRGM, where the behavior of software failure is assumed to follow a non-homogeneous Poisson process. Two types of modeling schemes based on a particular underlying method are proposed in order to more precisely estimate and predict the number of software defects based on very rare software failure data. The Bayesian statistical inference is employed to estimate the model parameters by incorporating software test cases as a covariate into the model. It was identified that these models are capable of reasonably estimating the remaining number of software defects which directly affects the reactor trip functions. The software reliability might be estimated from these modeling equations, and one approach of obtaining software reliability value is proposed in this paper.

  8. Agile software development

    CERN Document Server

    Stober, Thomas

    2009-01-01

    Software Development is moving towards a more agile and more flexible approach. It turns out that the traditional 'waterfall' model is not supportive in an environment where technical, financial and strategic constraints are changing almost every day. But what is agility? What are today's major approaches? And especially: What is the impact of agile development principles on the development teams, on project management and on software architects? How can large enterprises become more agile and improve their business processes, which have been existing since many, many years? What are the limit

  9. Software Testing as Science

    Directory of Open Access Journals (Sweden)

    Ingrid Gallesdic

    2013-06-01

    Full Text Available The most widespread opinion among people who have some connection with software testing is that this activity is an art. In fact, books have been published widely whose titles refer to it as art, role or process. But because software complexity is increasing every year, this paper proposes a new approach, conceiving the test as a science. This is because the processes by which they are applied are the steps of the scientific method: inputs, processes, outputs. The contents of this paper examines the similarities and test characteristics as science.

  10. Provider software buyer's guide.

    Science.gov (United States)

    1994-03-01

    To help long term care providers find new ways to improve quality of care and efficiency, Provider magazine presents the fourth annual listing of software firms marketing computer programs for all areas of nursing facility operations. On the following five pages, more than 80 software firms display their wares, with programs such as minimum data set and care planning, dietary, accounting and financials, case mix, and medication administration records. The guide also charts compatible hardware, integration ability, telephone numbers, company contacts, and easy-to-use reader service numbers.

  11. Model of software quality

    OpenAIRE

    Valencia Ayala, Luz Estela; Villa Sánchez, Paula Andréa; Ocampo S., Carlos Alberto

    2009-01-01

    En un mercado globalizado donde las empresas deben innovar y mejorar continuamente para crecer y ser más competitivas, es necesario tener acceso a certificaciones de calidad internacionales que les den un respaldo y puedan mantenerse en este mercado. Las certificaciones de calidad en la industria del software ayudan a las empresas a ser más productivas disminuyendo costos y tiempo en sus desarrollos. Las empresas de desarrollo de software de nuestro país en su mayoría son micro y pequeñas...

  12. Security System Software

    Science.gov (United States)

    1993-01-01

    C Language Integration Production System (CLIPS), a NASA-developed expert systems program, has enabled a security systems manufacturer to design a new generation of hardware. C.CURESystem 1 Plus, manufactured by Software House, is a software based system that is used with a variety of access control hardware at installations around the world. Users can manage large amounts of information, solve unique security problems and control entry and time scheduling. CLIPS acts as an information management tool when accessed by C.CURESystem 1 Plus. It asks questions about the hardware and when given the answer, recommends possible quick solutions by non-expert persons.

  13. Software product quality control

    CERN Document Server

    Wagner, Stefan

    2013-01-01

    Quality is not a fixed or universal property of software; it depends on the context and goals of its stakeholders. Hence, when you want to develop a high-quality software system, the first step must be a clear and precise specification of quality. Yet even if you get it right and complete, you can be sure that it will become invalid over time. So the only solution is continuous quality control: the steady and explicit evaluation of a product's properties with respect to its updated quality goals.This book guides you in setting up and running continuous quality control in your environment. Star

  14. Software Safety and Security

    CERN Document Server

    Nipkow, T; Hauptmann, B

    2012-01-01

    Recent decades have seen major advances in methods and tools for checking the safety and security of software systems. Automatic tools can now detect security flaws not only in programs of the order of a million lines of code, but also in high-level protocol descriptions. There has also been something of a breakthrough in the area of operating system verification. This book presents the lectures from the NATO Advanced Study Institute on Tools for Analysis and Verification of Software Safety and Security; a summer school held at Bayrischzell, Germany, in 2011. This Advanced Study Institute was

  15. Maintenance simulation: Software issues

    Energy Technology Data Exchange (ETDEWEB)

    Luk, C.H.; Jette, M.A.

    1995-07-01

    The maintenance of a distributed software system in a production environment involves: (1) maintaining software integrity, (2) maintaining and database integrity, (3) adding new features, and (4) adding new systems. These issues will be discussed in general: what they are and how they are handled. This paper will present our experience with a distributed resource management system that accounts for resources consumed, in real-time, on a network of heterogenous computers. The simulated environments to maintain this system will be presented relate to the four maintenance areas.

  16. Processeringsoptimering med Canons software

    DEFF Research Database (Denmark)

    Precht, Helle

    2009-01-01

    . Muligheder i software optimering blev studeret i relation til optimal billedkvalitet og kontrol optagelser, for at undersøge om det var muligt at acceptere diagnostisk billedkvalitet og derved tage afsæt i ALARA. Metode og materialer Et kvantitativt eksperimentelt studie baseret på forsøg med teknisk og...... humant fantom. CD Rad fantom anvendes som teknisk fantom, hvor billederne blev analyseret med CD Rad software, og resultatet var en objektiv IQF værdi. Det humane fantom var et lamme pelvis med femur, der via NRPB’ er sammenlignelig med absorptionen ved et femårigt barn. De humane forsøgsbilleder blev...

  17. Agile distributed software development

    DEFF Research Database (Denmark)

    Persson, John Stouby; Mathiassen, Lars; Aaen, Ivan

    2012-01-01

    While face-to-face interaction is fundamental in agile software development, distributed environments must rely extensively on mediated interactions. Practicing agile principles in distributed environments therefore poses particular control challenges related to balancing fixed vs. evolving quality...... requirements and people vs. process-based collaboration. To investigate these challenges, we conducted an in-depth case study of a successful agile distributed software project with participants from a Russian firm and a Danish firm. Applying Kirsch’s elements of control framework, we offer an analysis of how...

  18. Six Sigma software development

    CERN Document Server

    Tayntor, Christine B

    2002-01-01

    Since Six Sigma has had marked success in improving quality in other settings, and since the quality of software remains poor, it seems a natural evolution to apply the concepts and tools of Six Sigma to system development and the IT department. Until now however, there were no books available that applied these concepts to the system development process. Six Sigma Software Development fills this void and illustrates how Six Sigma concepts can be applied to all aspects of the evolving system development process. It includes the traditional waterfall model and in the support of legacy systems,

  19. Inventory of safeguards software

    International Nuclear Information System (INIS)

    Suzuki, Mitsutoshi; Horino, Koichi

    2009-03-01

    The purpose of this survey activity will serve as a basis for determining what needs may exist in this arena for development of next-generation safeguards systems and approaches. 23 software tools are surveyed by JAEA and NMCC. Exchanging information regarding existing software tools for safeguards and discussing about a next R and D program of developing a general-purpose safeguards tool should be beneficial to a safeguards system design and indispensable to evaluate a safeguards system for future nuclear fuel facilities. (author)

  20. Machine Tool Software

    Science.gov (United States)

    1988-01-01

    A NASA-developed software package has played a part in technical education of students who major in Mechanical Engineering Technology at William Rainey Harper College. Professor Hack has been using (APT) Automatically Programmed Tool Software since 1969 in his CAD/CAM Computer Aided Design and Manufacturing curriculum. Professor Hack teaches the use of APT programming languages for control of metal cutting machines. Machine tool instructions are geometry definitions written in APT Language to constitute a "part program." The part program is processed by the machine tool. CAD/CAM students go from writing a program to cutting steel in the course of a semester.