WorldWideScience

Sample records for environmental diagnostic analysis

  1. Environmental sensing and combustion diagnostics

    International Nuclear Information System (INIS)

    Santoleri, J.J.

    1991-01-01

    This book contains proceedings of Environmental Sensing and Combustion Diagnostics. Topics covered include: Incineration Systems Applications, Permitting, And Monitoring Overview; Infrared Techniques Applied to Incineration Systems; Continuous Emission Monitors; Analyzers and Sensors for Process Control And Environmental Monitoring

  2. New analysis methods to push the boundaries of diagnostic techniques in the environmental sciences

    International Nuclear Information System (INIS)

    Lungaroni, M.; Peluso, E.; Gelfusa, M.; Malizia, A.; Talebzadeh, S.; Gaudio, P.; Murari, A.; Vega, J.

    2016-01-01

    In the last years, new and more sophisticated measurements have been at the basis of the major progress in various disciplines related to the environment, such as remote sensing and thermonuclear fusion. To maximize the effectiveness of the measurements, new data analysis techniques are required. First data processing tasks, such as filtering and fitting, are of primary importance, since they can have a strong influence on the rest of the analysis. Even if Support Vector Regression is a method devised and refined at the end of the 90s, a systematic comparison with more traditional non parametric regression methods has never been reported. In this paper, a series of systematic tests is described, which indicates how SVR is a very competitive method of non-parametric regression that can usefully complement and often outperform more consolidated approaches. The performance of Support Vector Regression as a method of filtering is investigated first, comparing it with the most popular alternative techniques. Then Support Vector Regression is applied to the problem of non-parametric regression to analyse Lidar surveys for the environments measurement of particulate matter due to wildfires. The proposed approach has given very positive results and provides new perspectives to the interpretation of the data.

  3. The Application of Whole Cell-Based Biosensors for Use in Environmental Analysis and in Medical Diagnostics

    Science.gov (United States)

    Gui, Qingyuan; Lawson, Tom; Shan, Suyan; Yan, Lu; Liu, Yong

    2017-01-01

    Various whole cell-based biosensors have been reported in the literature for the last 20 years and these reports have shown great potential for their use in the areas of pollution detection in environmental and in biomedical diagnostics. Unlike other reviews of this growing field, this mini-review argues that: (1) the selection of reporter genes and their regulatory proteins are directly linked to the performance of celllular biosensors; (2) broad enhancements in microelectronics and information technologies have also led to improvements in the performance of these sensors; (3) their future potential is most apparent in their use in the areas of medical diagnostics and in environmental monitoring; and (4) currently the most promising work is focused on the better integration of cellular sensors with nano and micro scaled integrated chips. With better integration it may become practical to see these cells used as (5) real-time portable devices for diagnostics at the bedside and for remote environmental toxin detection and this in situ application will make the technology commonplace and thus as unremarkable as other ubiquitous technologies. PMID:28703749

  4. Environmental Analysis

    Science.gov (United States)

    1980-01-01

    Burns & McDonnell Engineering's environmental control study is assisted by NASA's Computer Software Management and Information Center's programs in environmental analyses. Company is engaged primarily in design of such facilities as electrical utilities, industrial plants, wastewater treatment systems, dams and reservoirs and aviation installations. Company also conducts environmental engineering analyses and advises clients as to the environmental considerations of a particular construction project. Company makes use of many COSMIC computer programs which have allowed substantial savings.

  5. Fluorescence spectroscopy for medical and environmental diagnostics

    International Nuclear Information System (INIS)

    Johansson, Jonas.

    1993-09-01

    Fluorescence spectroscopy can be used for diagnostics in medical and environmental applications. The many aspects of fluorescence emission are utilized to enhance the accuracy of the diagnosis. A fluorescence detection system, based on nitrogen laser or dye laser excitation and optical multichannel detection, was constructed, and fluorescence spectra from human malignant tumours of various origins, were recorded. Tumour demarcation was observed using exogenous chromophores, as well as the endogenous tissue fluorescence. In particular, δ-amino levulinic acid was found to provide very good tumour demarcation. A multi-colour imaging system capable of simultaneous recording of four fluorescence images at selected wavelengths, was developed. Examples of processed images, based on the four sub-images, are shown for malignant tumours. In addition, data from photodynamic treatment of human malignant tumours are presented. Autofluorescence spectra from excised pieces of human atherosclerotic aorta and atherosclerotic coronary segment were found to be different from those of non-diseased vessels. Furthermore, fluorescence decay curves from atherosclerotic samples were found to differ from those of non-diseased samples. It is concluded that both spectral and temporal information should be utilized to enhance the demarcation. Methods for obtaining fluorescence data free from interference from blood, with applications to in vivo laser angioplasty of atherosclerosis, are discussed. The optical multichannel system and the multi-colour imaging system were integrated with a remote sensing system, originally used for environmental measurements, to obtain fluorescence spectra as well as fluorescence images of plants at a distance of up to 100 m. The fluorescence data from plants subject to environmental stress or senescent plants were found to differ from those obtained from healthy vegetation. 359 refs

  6. Selective detection of Co2+ by fluorescent nano probe: Diagnostic approach for analysis of environmental samples and biological activities

    Science.gov (United States)

    Mahajan, Prasad G.; Dige, Nilam C.; Desai, Netaji K.; Patil, Shivajirao R.; Kondalkar, Vijay V.; Hong, Seong-Karp; Lee, Ki Hwan

    2018-06-01

    Nowadays scientist over the world are engaging to put forth improved methods to detect metal ion in an aqueous medium based on fluorescence studies. A simple, selective and sensitive method was proposed for detection of Co2+ ion using fluorescent organic nanoparticles. We synthesized a fluorescent small molecule viz. 4,4‧-{benzene-1,4-diylbis-[(Z)methylylidenenitrilo]}dibenzoic acid (BMBA) to explore its suitability as sensor for Co2+ ion and biocompatibility in form of nanoparticles. Fluorescence nanoparticles (BMBANPs) prepared by simple reprecipitation method. Aggregation induced enhanced emission of BMBANPs exhibits the narrower particle size of 68 nm and sphere shape morphology. The selective fluorescence quenching was observed by addition of Co2+ and does not affected by presence of other coexisting ion solutions. The photo-physical properties, viz. UV-absorption, fluorescence emission, and lifetime measurements are in support of ligand-metal interaction followed by static fluorescence quenching phenomenon in emission of BMBANPs. Finally, we develop a simple analytical method for selective and sensitive determination of Co2+ ion in environmental samples. The cell culture E. coli, Bacillus sps., and M. tuberculosis H37RV strain in the vicinity of BMBANPs indicates virtuous anti-bacterial and anti-tuberculosis activity which is of additional novel application shown by prepared nanoparticles.

  7. Oil analysis in machine diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Vaehaeoja, P.

    2006-07-01

    This study concentrates on developing and tuning various oil analysis methods to meet the requirements of modern industry and environmental analytics. Oil analysis methods form a vital part of techniques used to monitor the condition of machines and may help to improve the overall equipment effectiveness value of a factory in a significant manner. Worm gears are used in various production machines, and their breakdowns may cause significant production losses. Wearing of these gears is relatively difficult to monitor with vibration analysis. Analysis of two indicator metals, copper and iron, may reveal wearing phenomena of worm gears effectively, and savings can be significant. Effective wear metal analysis requires good tools. ICP-OES with kerosene dilution is widely used in wear metal analysis, but purchasing and using of ICP-OES is expensive. A cheaper FAAS technique with similar pre-treatment of oil samples was tested and it proved to be useful especially in analyzing small amounts of samples. The accuracy of FAAS was sufficient for quantitative work in machine diagnostics and waste oil characterization. Solid debris analyses are useful in oil contamination control as well as in detection of wearing mechanisms. Membrane filtration, optical microscopy, SEM and automatic particle counting were applied in analysis of rolling and gear oils. Particle counting is an effective way to detect oil contamination, but in the studied cases even larger particles than those detected in normal ISO classes would be informative. However, membrane filtration and optical microscopy may reveal the wearing machine element exactly. Additives provide oils with desired properties thus they should be monitored intensively. A FTIR method for quantitative analysis of fatty alcohols and fatty acid esters in machinery oils was developed during this work. It has already been used successfully in quantitative and qualitative analysis of machinery oil samples. Various kinds of oils may be

  8. Environmental Perception as a Diagnostic Probe of Environmental Complexity Levels

    Science.gov (United States)

    Freitas, Mirlaine R.; Macedo, Renato L. G.; Freitas, Matheus P.; Nunes, Cleiton A.; Venturin, Nelson

    2015-01-01

    Purpose: Educational methods to diagnose and improve the level of environmental conception are required. The present work reports a methodology based on studies about the environmental perception of a university public, divided into general students and those related to the forest sciences, who are involved with disciplines and researches related…

  9. Diagnostic herd sensitivity using environmental samples

    DEFF Research Database (Denmark)

    Vigre, Håkan; Josefsen, Mathilde Hartmann; Seyfarth, Anne Mette

    either at farm or slaughter. Three sample matrices were collected; dust samples (5 environmental swabs), nasal swabs (10 pools with 5 animals per pool) and air samples (1 filter). Based on the assumption that MRSA occurred in all 48 herds the overall herd sensitivity was 58% for nasal swabs, 33% for dust....... In our example, the prevalence of infected pigs in each herd was estimated from the pooled samples of nasal swabs. Logistic regression was used to estimate the effect of animal prevalence on the probability to detect MRSA in the dust and air samples at herd level. The results show a significant increase...

  10. Cell Analysis and Early Diagnostics

    NARCIS (Netherlands)

    Subramaniam, Vinod; Jones, Val

    2006-01-01

    In an era of aging populations and rising health-care costs, the shift of medical paradigms towards rapid, accurate, early diagnoses of diseases is inevitable. In addition to further development of ultrasensitive in vitro tests, the focus of attention in both diagnostics and the early drug discovery

  11. Environmental policy analysis

    International Nuclear Information System (INIS)

    Anon.

    1978-01-01

    The Environmental Policy Analysis Program was established to improve the formation of energy development and environmental policies with due mutual regard for national environmental and energy development needs. As a separate office under the Assistant Secretary for Environment, the program is implemented by the Director and by Offices of Environmental Policy Analysis in the eight DOE multiprogram laboratories. The program provides the Assistant Secretary with information on alternatives for decision making and early warning of environmental problems and considerations that may affect energy policy decisions. The program is intended to be a continuing activity, with its scope determined progressively as issues are defined. During FY-1977 the program focused on information compilation on levels of Pu and other transuranic elements in soils that would render the area unsafe for unlimited use; the impact of water pollution control laws on energy technologies; an analysis of the comparative health risks associated with various energy technologies; and the cost and related impacts on the nuclear industry arising from changes in radiation standards during the past 15 years

  12. Diagnostics

    DEFF Research Database (Denmark)

    Donné, A.J.H.; Costley, A.E.; Barnsley, R.

    2007-01-01

    of the measurements—time and spatial resolutions, etc—will in some cases be more stringent. Many of the measurements will be used in the real time control of the plasma driving a requirement for very high reliability in the systems (diagnostics) that provide the measurements. The implementation of diagnostic systems...... on ITER is a substantial challenge. Because of the harsh environment (high levels of neutron and gamma fluxes, neutron heating, particle bombardment) diagnostic system selection and design has to cope with a range of phenomena not previously encountered in diagnostic design. Extensive design and R......&D is needed to prepare the systems. In some cases the environmental difficulties are so severe that new diagnostic techniques are required. The starting point in the development of diagnostics for ITER is to define the measurement requirements and develop their justification. It is necessary to include all...

  13. Environmental risk analysis

    International Nuclear Information System (INIS)

    Lima-e-Silva, Pedro Paulo de

    1996-01-01

    The conventional Risk Analysis (RA) relates usually a certain undesired event frequency with its consequences. Such technique is used nowadays in Brazil to analyze accidents and their consequences strictly under the human approach, valuing loss of human equipment, human structures and human lives, without considering the damage caused to natural resources that keep life possible on Earth. This paradigm was developed primarily because of the Homo sapiens' lack of perception upon the natural web needed to sustain his own life. In reality, the Brazilian professionals responsible today for licensing, auditing and inspecting environmental aspects of human activities face huge difficulties in making technical specifications and procedures leading to acceptable levels of impact, furthermore considering the intrinsic difficulties to define those levels. Therefore, in Brazil the RA technique is a weak tool for licensing for many reasons, and of them are its short scope (only accident considerations) and wrong a paradigm (only human direct damages). A paper from the author about the former was already proposed to the 7th International Conference on Environmetrics, past July'96, USP-SP. This one discusses the extension of the risk analysis concept to take into account environmental consequences, transforming the conventional analysis into a broader methodology named here as Environmental Risk Analysis. (author)

  14. The proposed Diagnostic Instrumentation and Analysis Laboratory, Mississippi State University

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1994-11-01

    The Department of Energy (DOE) proposes to authorize Mississippi State University (MSU) to proceed with the detailed design, construction and equipping of the proposed Diagnostic Instrumentation and Analysis Laboratory (DIAL). DOE grant funds are available to the University for the limited purpose of performing preliminary studies, including analysis necessary to conduct this environmental assessment. The proposed facility would be located in the Mississippi Research and Technology Park, adjacent to the Mississippi Agriculture and Forestry Experiment Station campus in Starkville, Mississippi. Total project cost is estimated at $7,953,600. This proposed laboratory would be designed to conduct research into combustion devices related to waste management and environmental restoration that is of importance to industry and government. The proposed facility`s role would be to develop diagnostic instrumentation capabilities in the area of combustion and related processes.

  15. Environmental analysis support

    International Nuclear Information System (INIS)

    Miller, R.L.

    1994-01-01

    Activities in environmental analysis support included assistance to the Morgantown and Pittsburgh Energy Technology Centers (METC and PETC) in reviewing and preparing documents required by the National Environmental Policy Act (NEPA) for several projects selected for the Clean Coal Technology (CCT) Program. A key milestone was the completion for PETC of the final Environmental Impact Statement (EIS) for the Healy Clean Coal Project (HCCP) in Healy, Alaska. This work is notable because it is the first site-specific EIS completed for the CCT Program. Another important activity was the preparation for METC of a draft Environmental Assessment (EA) for the Externally Fired Combined Cycle (EFCC) Project in Warren, Pennsylvania. Also, the final EA was completed for the Gasification Product Improvement Facility (GPIF), a proposed project near Morgantown, West Virginia, which is part of METC's R ampersand D Program. In addition, ORNL staff members published a Technical Memorandum entitled open-quotes Potential Effects of Clean Coal Technologies on Acid Precipitation, Greenhouse Gases, and Solid Waste Disposalclose quotes which documents the findings of three open-quotes white papersclose quotes prepared for DOE/FE

  16. Bayesian analysis of ion beam diagnostics

    International Nuclear Information System (INIS)

    Toussaint, U. von; Fischer, R.; Dose, V.

    2001-01-01

    Ion beam diagnostics are routinely used for quantitative analysis of the surface composition of mixture materials up to a depth of a few μm. Unfortunately, advantageous properties of the diagnostics, like high depth resolution in combination with a large penetration depth, no destruction of the surface, high sensitivity for large as well as for small atomic numbers, and high sensitivity are mutually exclusive. Among other things, this is due to the ill-conditioned inverse problem of reconstructing depth distributions of the composition elements. Robust results for depth distributions are obtained with adaptive methods in the framework of Bayesian probability theory. The method of adaptive kernels allows for distributions which contain only the significant information of the data while noise fitting is avoided. This is achieved by adaptively reducing the degrees of freedom supporting the distribution. As applications for ion beam diagnostics Rutherford backscattering spectroscopy and particle induced X-ray emission are shown

  17. Microbial Diagnostic Array Workstation (MDAW: a web server for diagnostic array data storage, sharing and analysis

    Directory of Open Access Journals (Sweden)

    Chang Yung-Fu

    2008-09-01

    Full Text Available Abstract Background Microarrays are becoming a very popular tool for microbial detection and diagnostics. Although these diagnostic arrays are much simpler when compared to the traditional transcriptome arrays, due to the high throughput nature of the arrays, the data analysis requirements still form a bottle neck for the widespread use of these diagnostic arrays. Hence we developed a new online data sharing and analysis environment customised for diagnostic arrays. Methods Microbial Diagnostic Array Workstation (MDAW is a database driven application designed in MS Access and front end designed in ASP.NET. Conclusion MDAW is a new resource that is customised for the data analysis requirements for microbial diagnostic arrays.

  18. Diagnostics for environmental aspects of pulsed atmospheric discharges

    International Nuclear Information System (INIS)

    Rutgers, W.R.; Veldhuizen, E.M. van

    2001-01-01

    Diagnostics for the study of pulsed atmospheric discharges are discussed. To obtain parameters for describing conversion processes of pollutants into harmless products many diagnostic techniques are in use and under development. In this contribution electrical, optical and chemical diagnostics used in air and wastewater remediation are reviewed

  19. Diagnostics for environmental aspects of pulsed atmospheric discharges

    Energy Technology Data Exchange (ETDEWEB)

    Rutgers, W.R.; Veldhuizen, E.M. van [Eindhoven Univ. of Technology (Netherlands). Dept. of Applied Physics

    2001-07-01

    Diagnostics for the study of pulsed atmospheric discharges are discussed. To obtain parameters for describing conversion processes of pollutants into harmless products many diagnostic techniques are in use and under development. In this contribution electrical, optical and chemical diagnostics used in air and wastewater remediation are reviewed.

  20. Optical spectra analysis for breast cancer diagnostics

    Science.gov (United States)

    Belkov, S. A.; Kochemasov, G. G.; Lyubynskaya, T. E.; Maslov, N. V.; Nuzhny, A. S.; da Silva, L. B.; Rubenchik, A.

    2011-11-01

    Minimally invasive probe and optical biopsy system based on optical spectra recording and analysis seem to be a promising tool for early diagnostics of breast cancer. Light scattering and absorption spectra are generated continuously as far as the needle-like probe with one emitting and several collecting optical fibers penetrates through the tissues toward to the suspicious area. That allows analyzing not only the state of local site, but also the structure of tissues along the needle trace. The suggested method has the advantages of automated on-line diagnosing and minimal tissue destruction and in parallel with the conventional diagnostic procedures provides the ground for decision-making. 165 medical trials were completed in Nizhny Novgorod Regional Oncology Centre, Russia. Independent diagnoses were the results of fine biopsy and histology. Application of wavelet expansion and clasterization techniques for spectra analysis revealed several main spectral types for malignant and benign tumors. Automatic classification algorithm demonstrated specificity ˜90% and sensitivity ˜91%. Large amount of information, fuzziness in criteria and data noisiness make neural networks to be an attractive analytic tool. The model based on three-layer perceptron was tested over the sample of 29 `cancer' and 29 `non-cancer' cases and demonstrated total separation.

  1. Enhanced vibration diagnostics using vibration signature analysis

    International Nuclear Information System (INIS)

    Ahmed, S.; Shehzad, K.; Zahoor, Y.; Mahmood, A.; Bibi, A.

    2001-01-01

    Symptoms will appear in equipment, as well as in human beings. when 'suffering from sickness. Symptoms of abnormality in equipment are vibration, noise, deformation, temperature, pressure, electric current, crack, wearing, leakage etc. these are called modes of failure. If the mode of failure is vibration then the vibration signature analysis can be effectively used in order to diagnose the machinery problems. Much valuable information is contained within these vibration 'Spectra' or 'Signatures' but is only of use if the analyst can unlock its 'Secrets'. This paper documents a vibration problem in the motor of a centrifugal pump (Type ETA). It focuses mainly on the roll of modern vibration monitoring system in problem analysis. The problem experienced was the motor unstability and noise due to high vibration. Using enhanced vibration signature data, the problem was analyzed. which suggested that the rotor eccentricity was the cause of excessive noise and vibration in the motor. In conclusion, advanced electronic monitoring and diagnostic systems provide powerful information for machine's condition assessment and problem analysis. Appropriate interpretation and use of this information is important for accurate and effective vibration analysis. (author)

  2. Environmental conditions analysis program

    International Nuclear Information System (INIS)

    Holten, J.

    1991-01-01

    The PC-based program discussed in this paper has the capability of determining the steady state temperatures of environmental zones (rooms). A program overview will be provided along with examples of formula use. Required input and output from the program will also be discussed. Specific application of plant monitored temperatures and utilization of this program will be offered. The presentation will show how the program can project individual room temperature profiles without continual temperature monitoring of equipment. A discussion will also be provided for the application of the program generated data. Evaluations of anticipated or planned plant modifications and the use of the subject program will also be covered

  3. Application of noise analysis methods in nuclear reactor diagnostics

    International Nuclear Information System (INIS)

    Dach, K.

    1985-01-01

    By statistical evaluation of the fluctuation component of signals from selected detectors, noise diagnostics detects conditions of equipment which might later result in failure. The objective of early diagnostics is to detect the failed integrity of primary circuit components, failed detectors or anomalies of the thermohydraulic process. The commonest method of experimental data analysis is spectral analysis in the frequency range 0 to 50 Hz. Recently, expert diagnostic systems have been built based on artificial intelligence systems. Czechoslovakia participates in the experimental research of noise diagnostics in the context of the development of diagnostic assemblies for WWER-440 reactors. (M.D.)

  4. Battery Test Facility- Electrochemical Analysis and Diagnostics Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — The Electrochemical Analysis and Diagnostics Laboratory (EADL) provides battery developers with reliable, independent, and unbiased performance evaluations of their...

  5. Analysis of environmental sounds

    Science.gov (United States)

    Lee, Keansub

    Environmental sound archives - casual recordings of people's daily life - are easily collected by MPS players or camcorders with low cost and high reliability, and shared in the web-sites. There are two kinds of user generated recordings we would like to be able to handle in this thesis: Continuous long-duration personal audio and Soundtracks of short consumer video clips. These environmental recordings contain a lot of useful information (semantic concepts) related with activity, location, occasion and content. As a consequence, the environment archives present many new opportunities for the automatic extraction of information that can be used in intelligent browsing systems. This thesis proposes systems for detecting these interesting concepts on a collection of these real-world recordings. The first system is to segment and label personal audio archives - continuous recordings of an individual's everyday experiences - into 'episodes' (relatively consistent acoustic situations lasting a few minutes or more) using the Bayesian Information Criterion and spectral clustering. The second system is for identifying regions of speech or music in the kinds of energetic and highly-variable noise present in this real-world sound. Motivated by psychoacoustic evidence that pitch is crucial in the perception and organization of sound, we develop a noise-robust pitch detection algorithm to locate speech or music-like regions. To avoid false alarms resulting from background noise with strong periodic components (such as air-conditioning), a new scheme is added in order to suppress these noises in the domain of autocorrelogram. In addition, the third system is to automatically detect a large set of interesting semantic concepts; which we chose for being both informative and useful to users, as well as being technically feasible. These 25 concepts are associated with people's activities, locations, occasions, objects, scenes and sounds, and are based on a large collection of

  6. Applications of air ion measurement in environmental diagnostics

    International Nuclear Information System (INIS)

    Tammet, H.

    1996-01-01

    The present paper is dealing with the methods employing the measuring of naturally created air ions. The amount and mobility distribution of these ions offer hidden information about air pollution. On the other hand, the natural air ions are active in some environmental processes and they should be considered as an immediate environmental factor

  7. MOLECULAR DIAGNOSTICS - ANOTHER PIECE IN THE ENVIRONMENTAL PUZZLE

    Science.gov (United States)

    Molecular biology offers sensitive and expedient tools for the detection of exposure to environmental stressors. Molecular approaches provide the means for detection of the "first cellular event(s)" in response to environmental changes-specifically, immediate changes in gene expr...

  8. Analysis of licensed South African diagnostic imaging equipment ...

    African Journals Online (AJOL)

    Analysis of licensed South African diagnostic imaging equipment. ... Pan African Medical Journal ... Introduction: Objective: To conduct an analysis of all registered South Africa (SA) diagnostic radiology equipment, assess the number of equipment units per capita by imaging modality, and compare SA figures with published ...

  9. POSSIBILITY OF THE WHO GREEN PAGE ENVIRONMENTAL HEALTH DIAGNOSTICS IMPLEMENTATION IN PRIMARY CARE

    Directory of Open Access Journals (Sweden)

    Donata Kurpas

    2010-12-01

    Full Text Available The aim is to define workable framework for implementation of the WHO Green Page Environmental Health Diagnostics in primary care. The study was carried out with the employment standard form questionnaire among parents of children. 159 parents took part in the study. 34 (24.3% of parents expressed their concern about the child’s environment. 23.7% of the examined demonstrated awareness of existing environmental risks. The Green Page allows for an approximation to environmental diagnostics to characterize positive or negative factors and detection of the most vulnerable individuals or groups.

  10. Uncertainty analysis of environmental models

    International Nuclear Information System (INIS)

    Monte, L.

    1990-01-01

    In the present paper an evaluation of the output uncertainty of an environmental model for assessing the transfer of 137 Cs and 131 I in the human food chain are carried out on the basis of a statistical analysis of data reported by the literature. The uncertainty analysis offers the oppotunity of obtaining some remarkable information about the uncertainty of models predicting the migration of non radioactive substances in the environment mainly in relation to the dry and wet deposition

  11. Analysis of the Astronomy Diagnostic Test

    Science.gov (United States)

    Brogt, Erik; Sabers, Darrell; Prather, Edward E.; Deming, Grace L.; Hufnagel, Beth; Slater, Timothy F.

    2007-01-01

    Seventy undergraduate class sections were examined from the database of Astronomy Diagnostic Test (ADT) results of Deming and Hufnagel to determine if course format correlated with ADT normalized gain scores. Normalized gains were calculated for four different classroom scenarios: lecture, lecture with discussion, lecture with lab, and lecture…

  12. Timor-Leste : Country Environmental Analysis

    OpenAIRE

    World Bank

    2009-01-01

    The Country Environmental Analysis (CEA) for Timor-Leste identifies environmental priorities through a systematic review of environmental issues in natural resources management and environmental health in the context of the country's economic development and environmental institutions. Lack of data has been the main limitation in presenting a more rigorous analysis. Nevertheless, the repor...

  13. Environmental sampling for trace analysis

    International Nuclear Information System (INIS)

    Markert, B.

    1994-01-01

    Often too little attention is given to the sampling before and after actual instrumental measurement. This leads to errors, despite increasingly sensitive analytical systems. This is one of the first books to pay proper attention to representative sampling. It offers an overview of the most common techniques used today for taking environmental samples. The techniques are clearly presented, yield accurate and reproducible results and can be used to sample -air - water - soil and sediments - plants and animals. A comprehensive handbook, this volume provides an excellent starting point for researchers in the rapidly expanding field of environmental analysis. (orig.)

  14. Analysis of Vibration Diagnostics Methods for Induction Motors

    Directory of Open Access Journals (Sweden)

    A. P. Kalinov

    2012-01-01

    Full Text Available The paper presents an analysis of existing vibration diagnostics methods. In order to evaluate an efficiency of method application the following criteria have been proposed: volume of input data required for establishing diagnosis, data content, software and hardware level, execution time for vibration diagnostics. According to the mentioned criteria a classification of vibration diagnostics methods for determination of their advantages and disadvantages, search for their development and improvement has been presented in paper. The paper contains a comparative estimation of methods in accordance with the proposed  criteria. According to this estimation the most efficient methods are a spectral analysis and spectral analysis of the vibration signal envelope.

  15. Immunochromatographic diagnostic test analysis using Google Glass.

    Science.gov (United States)

    Feng, Steve; Caire, Romain; Cortazar, Bingen; Turan, Mehmet; Wong, Andrew; Ozcan, Aydogan

    2014-03-25

    We demonstrate a Google Glass-based rapid diagnostic test (RDT) reader platform capable of qualitative and quantitative measurements of various lateral flow immunochromatographic assays and similar biomedical diagnostics tests. Using a custom-written Glass application and without any external hardware attachments, one or more RDTs labeled with Quick Response (QR) code identifiers are simultaneously imaged using the built-in camera of the Google Glass that is based on a hands-free and voice-controlled interface and digitally transmitted to a server for digital processing. The acquired JPEG images are automatically processed to locate all the RDTs and, for each RDT, to produce a quantitative diagnostic result, which is returned to the Google Glass (i.e., the user) and also stored on a central server along with the RDT image, QR code, and other related information (e.g., demographic data). The same server also provides a dynamic spatiotemporal map and real-time statistics for uploaded RDT results accessible through Internet browsers. We tested this Google Glass-based diagnostic platform using qualitative (i.e., yes/no) human immunodeficiency virus (HIV) and quantitative prostate-specific antigen (PSA) tests. For the quantitative RDTs, we measured activated tests at various concentrations ranging from 0 to 200 ng/mL for free and total PSA. This wearable RDT reader platform running on Google Glass combines a hands-free sensing and image capture interface with powerful servers running our custom image processing codes, and it can be quite useful for real-time spatiotemporal tracking of various diseases and personal medical conditions, providing a valuable tool for epidemiology and mobile health.

  16. Cost-benefit analysis in decision making for diagnostic radiology

    International Nuclear Information System (INIS)

    Fabrikant, J.I.; Hilberg, A.W.

    1982-02-01

    This paper reviews certain current concepts and methods relating to benefit-risk analysis, in terms of economic costs and raidation risks to health, in relation to the benefits from diagnostic radiology in clinical medicine

  17. Statistical analysis of environmental data

    International Nuclear Information System (INIS)

    Beauchamp, J.J.; Bowman, K.O.; Miller, F.L. Jr.

    1975-10-01

    This report summarizes the analyses of data obtained by the Radiological Hygiene Branch of the Tennessee Valley Authority from samples taken around the Browns Ferry Nuclear Plant located in Northern Alabama. The data collection was begun in 1968 and a wide variety of types of samples have been gathered on a regular basis. The statistical analysis of environmental data involving very low-levels of radioactivity is discussed. Applications of computer calculations for data processing are described

  18. Development of ITER diagnostics: Neutronic analysis and radiation hardness

    Energy Technology Data Exchange (ETDEWEB)

    Vukolov, Konstantin, E-mail: vukolov_KY@nrcki.ru; Borisov, Andrey; Deryabina, Natalya; Orlovskiy, Ilya

    2015-10-15

    Highlights: • Problems of ITER diagnostics caused by neutron radiation from hot DT plasma considered. • Careful neutronic analysis is necessary for ITER diagnostics development. • Effective nuclear shielding for ITER diagnostics in the 11th equatorial port plug proposed. • Requirements for study of radiation hardness of diagnostic elements defined. • Results of optical glasses irradiation tests in a fission reactor given. - Abstract: The paper is dedicated to the problems of ITER diagnostics caused by effects of radiation from hot DT plasma. An effective nuclear shielding must be arranged in diagnostic port plugs to meet the nuclear safety requirements and to provide reliable operation of the diagnostics. This task can be solved with the help of neutronic analysis of the diagnostics environment within the port plugs at the design stage. Problems of neutronic calculations are demonstrated for the 11th equatorial port plug. The numerical simulation includes the calculations of neutron fluxes in the port-plug and in the interspace. Options for nuclear shielding, such as tungsten collimator, boron carbide and water moderators, stainless steel and lead screens are considered. Data on neutron fluxes along diagnostic labyrinths allow to define radiation hardness requirements for the diagnostic components and to specify their materials. Options for windows and lenses materials for optical diagnostics are described. The results of irradiation of flint and silica glasses in nuclear reactor have shown that silica KU-1 and KS-4V retain transparency in visible range after neutron fluence of 10{sup 17} cm{sup −2}. Flints required for achromatic objectives have much less radiation hardness about 5 × 10{sup 14} n/cm{sup 2}.

  19. Applications of ROC analysis in diagnostic image evaluation

    International Nuclear Information System (INIS)

    Metz, C.E.

    1979-01-01

    The need for Receiver Operating Characteristic (ROC) analysis is indicated by a discussion of the limitations of accuracy and of sensitivity and specificity as indices of diagnostic detection or discrmination performance. The concept of a variable decision threshold is shown to lead in a natural way to the ROC curve as a means for specifying diagnostic performance. Practical techniques for measuring ROC curves are described, and directions for possible generalizations of conventional ROC analysis are indicated

  20. Trace element analysis: a diagnostic tool

    International Nuclear Information System (INIS)

    Qureshi, I.H.; Cheema, M.N.

    1976-09-01

    The human mody continuously assimilates a variety of elements from the environment, and the concentration of these elements in the blood is regulated by means of various homeostatic mechanisms. Some of the elements, though present in very small amounts, have highly specialized functions in initiating many biochemical reactions. These elements, known as essential trace elements, are closely related to human diseases since their deficiency or excess induces physiological changes. Many diseases such as hypertension, atherosclerosis, diabetes, etc., are related to an imbalance in trace element. The measurement of trace elements in body fluids and tissues can, therefore, be effectively employed for diagnostic tests

  1. Plasma diagnostics surface analysis and interactions

    CERN Document Server

    Auciello, Orlando

    2013-01-01

    Plasmas and their interaction with materials have become subjects of major interest because of their importance in modern forefront technologies such as microelectronics, fusion energy, and space. Plasmas are used in microelectronics to process semiconductors (etching of patterns for microcircuits, plasma-induced deposition of thin films, etc.); plasmas produce deleterious erosion effects on surfaces of materials used for fusion devices and spaceships exposed to the low earth environment.Diagnostics of plasmas and materials exposed to them are fundamental to the understanding of the physical a

  2. Application of modern diagnostic methods to environmental improvement. Annual progress report, October 1994--September 1995

    International Nuclear Information System (INIS)

    Shepard, W.S.

    1995-12-01

    The Diagnostic Instrumentation and Analysis Laboratory (DIAL), an interdisciplinary research department in the College of Engineering at Mississippi State University (MSU), is under contract with the US Department of Energy (DOE) to develop and apply advanced diagnostic instrumentation and analysis techniques to aid in solving DOE's nuclear waste problem. The program is a comprehensive effort which includes five focus areas: advanced diagnostic systems; development/application; torch operation and test facilities; process development; on-site field measurement and analysis; technology transfer/commercialization. As part of this program, diagnostic methods will be developed and evaluated for characterization, monitoring and process control. Also, the measured parameters, will be employed to improve, optimize and control the operation of the plasma torch and the overall plasma treatment process. Moreover, on-site field measurements at various DOE facilities are carried out to aid in the rapid demonstration and implementation of modern fieldable diagnostic methods. Such efforts also provide a basis for technology transfer

  3. Application of modern diagnostic methods to environmental improvement. Annual progress report, October 1994--September 1995

    Energy Technology Data Exchange (ETDEWEB)

    Shepard, W.S.

    1995-12-01

    The Diagnostic Instrumentation and Analysis Laboratory (DIAL), an interdisciplinary research department in the College of Engineering at Mississippi State University (MSU), is under contract with the US Department of Energy (DOE) to develop and apply advanced diagnostic instrumentation and analysis techniques to aid in solving DOE`s nuclear waste problem. The program is a comprehensive effort which includes five focus areas: advanced diagnostic systems; development/application; torch operation and test facilities; process development; on-site field measurement and analysis; technology transfer/commercialization. As part of this program, diagnostic methods will be developed and evaluated for characterization, monitoring and process control. Also, the measured parameters, will be employed to improve, optimize and control the operation of the plasma torch and the overall plasma treatment process. Moreover, on-site field measurements at various DOE facilities are carried out to aid in the rapid demonstration and implementation of modern fieldable diagnostic methods. Such efforts also provide a basis for technology transfer.

  4. MEDICAL DIAGNOSTICS BY MICROSTRUCTURAL ANALYSIS OF BIOLOGICAL LIQUID DRIED PATTERNS AS A PROBLEM OF BIOINFORMATICS

    Directory of Open Access Journals (Sweden)

    Petr Vladimirovich Lebedev-Stepanov, Dr.

    2018-02-01

    Full Text Available Motivation: It is important to develop the high-precision computerized methods for medical rapid diagnostic which is generalizing the unique clinical experience obtained in the past decade as specialized solutions for diagnostic problems of control of specific diseases and, potentially, for a wide health monitoring of virtually healthy population, identify the reserves of human health and take the actions to prevent of these reserves depletion. In this work we present one of the new directions in bioinformatics, i.e. medical diagnostics by automated expert system on basis of morphology analysis of digital image of biological liquid dried pattern. Results: Proposed method is combination of bioinformatics and biochemistry approaches for obtaining diagnostic information from a morphological analysis of standardized dried patterns of biological liquid sessile drop. We have carried out own research in collaboration with medical diagnostic centers and formed the electronic database for recognition the following types of diseases: candidiasis; neoplasms; diabetes mellitus; diseases of the circulatory system; cerebrovascular disease; diseases of the digestive system; diseases of the genitourinary system; infectious diseases; factors relevant to the work; factors associated with environmental pollution; factors related to lifestyle. The laboratory setup for diagnostics of the human body in pathology states is developed. The diagnostic results are considered. Availability: Access to testing the software can be obtained on request to the contact email below.

  5. Open Rotor - Analysis of Diagnostic Data

    Science.gov (United States)

    Envia, Edmane

    2011-01-01

    NASA is researching open rotor propulsion as part of its technology research and development plan for addressing the subsonic transport aircraft noise, emission and fuel burn goals. The low-speed wind tunnel test for investigating the aerodynamic and acoustic performance of a benchmark blade set at the approach and takeoff conditions has recently concluded. A high-speed wind tunnel diagnostic test campaign has begun to investigate the performance of this benchmark open rotor blade set at the cruise condition. Databases from both speed regimes will comprise a comprehensive collection of benchmark open rotor data for use in assessing/validating aerodynamic and noise prediction tools (component & system level) as well as providing insights into the physics of open rotors to help guide the development of quieter open rotors.

  6. A new perspective into root-cause analysis and diagnostics

    International Nuclear Information System (INIS)

    Kim, Inn Seock; Kim, Tae Kwon; Kim, Min Chull

    1998-01-01

    A critical review of diagnostic and root-cause analysis methods, developed in nuclear, chemical process, aviation industries, was made. Based on this review, the insights into both off-line and on-line diagnostics, and also root-cause analysis are preseted from a new perspective. This perspective may be applied for various purposes, including real-time on-line process diagnosis, root-cause analysis of reactor scrams, diagnosis of severe accidents, or situation identification of an on-going emergency at a nuclear site

  7. Visualizing data for environmental analysis

    Energy Technology Data Exchange (ETDEWEB)

    Benson, J.

    1997-04-01

    The Environmental Restoration Project at Los Alamos National Laboratory (LANL) has over 11,000 sampling locations in a 44 square mile area. The sample analyses contain raw analytical chemistry values for over 2,300 analytes and compounds used to define and remediate contaminated areas at LANL. The data consist of 2.5 million records in an oracle database. Maps are often used to visualize the data. Problems arise when a client specifies a particular kind of map without fully understanding the limitations of the data or the map. The ability of maps to convey information is dependent on many factors, though all maps are data dependent. The quantity, spatial distribution, and numerical range of the data can limit use with certain kinds of maps. To address these issues and educate the clients, several types of statistical maps (e.g., choropleth, isarithm, and graduated symbol such as bubble and spike) used for environmental analysis were chosen to show the advantages, disadvantages, and data limitations of each. By examining both the complexity of the analytical data and the limitations of the map type, it is possible to consider how reality has been transformed through the map, and if that transformation accurately conveys the information present.

  8. Visualizing data for environmental analysis

    International Nuclear Information System (INIS)

    Benson, J.

    1997-01-01

    The Environmental Restoration Project at Los Alamos National Laboratory (LANL) has over 11,000 sampling locations in a 44 square mile area. The sample analyses contain raw analytical chemistry values for over 2,300 analytes and compounds used to define and remediate contaminated areas at LANL. The data consist of 2.5 million records in an oracle database. Maps are often used to visualize the data. Problems arise when a client specifies a particular kind of map without fully understanding the limitations of the data or the map. The ability of maps to convey information is dependent on many factors, though all maps are data dependent. The quantity, spatial distribution, and numerical range of the data can limit use with certain kinds of maps. To address these issues and educate the clients, several types of statistical maps (e.g., choropleth, isarithm, and graduated symbol such as bubble and spike) used for environmental analysis were chosen to show the advantages, disadvantages, and data limitations of each. By examining both the complexity of the analytical data and the limitations of the map type, it is possible to consider how reality has been transformed through the map, and if that transformation accurately conveys the information present

  9. Statistical evaluation of diagnostic performance topics in ROC analysis

    CERN Document Server

    Zou, Kelly H; Bandos, Andriy I; Ohno-Machado, Lucila; Rockette, Howard E

    2016-01-01

    Statistical evaluation of diagnostic performance in general and Receiver Operating Characteristic (ROC) analysis in particular are important for assessing the performance of medical tests and statistical classifiers, as well as for evaluating predictive models or algorithms. This book presents innovative approaches in ROC analysis, which are relevant to a wide variety of applications, including medical imaging, cancer research, epidemiology, and bioinformatics. Statistical Evaluation of Diagnostic Performance: Topics in ROC Analysis covers areas including monotone-transformation techniques in parametric ROC analysis, ROC methods for combined and pooled biomarkers, Bayesian hierarchical transformation models, sequential designs and inferences in the ROC setting, predictive modeling, multireader ROC analysis, and free-response ROC (FROC) methodology. The book is suitable for graduate-level students and researchers in statistics, biostatistics, epidemiology, public health, biomedical engineering, radiology, medi...

  10. Assessment of the Capability of the NGDS Prototype to Replace the JBAIDS for Environmental Sample Analysis

    Science.gov (United States)

    2016-11-01

    Diagnostic System (JBAIDS) for environmental sample analysis. JUPITR ATD and USAF members analyzed environmental samples using the FilmArray...requires 60+ min for sample preparation, whereas the FilmArray system (right) uses highly multiplexed assay pouches that require ᝺ min for sample...supported the evaluation of the BDCoE by analyzing spiked DFU samples using the Joint Biological Agent Identification and Diagnostic System (JBAIDS) and the

  11. Neutronics analysis for integration of ITER diagnostics port EP10

    Energy Technology Data Exchange (ETDEWEB)

    Colling, Bethany, E-mail: bethany.colling@ccfe.ac.uk [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Eade, Tim [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Joyce, Malcolm J. [Department of Engineering, Lancaster University, Lancashire LA1 4YR (United Kingdom); Pampin, Raul; Seyvet, Fabien [Fusion for Energy, Josep Pla 2, Torres Diagonal Litoral B3, 08019 Barcelona (Spain); Turner, Andrew [Culham Centre for Fusion Energy, Culham Science Centre, Abingdon, Oxon OX14 3DB (United Kingdom); Udintsev, Victor [ITER Organization, Route de Vinon-sur-Verdon, CS 90 046, 13067 St. Paul Lez Durance Cedex (France)

    2016-11-01

    Shutdown dose rate calculations have been performed on an integrated ITER C-lite neutronics model with equatorial port 10. A ‘fully shielded’ configuration, optimised for a given set of diagnostic designs (i.e. shielding in all available space within the port plug drawers), results in a shutdown dose rate in the port interspace, from the activation of materials comprising equatorial port 10, in excess of 2000 μSv/h. Achieving dose rates of 100 μSv/h or less, as required in areas where hands-on maintenance can be performed, in the port interspace region will be challenging. A combination of methods will need to be implemented, such as reducing mass and/or the use of reduced activation steel in the port interspace, optimisation of the diagnostic designs and shielding of the port interspace floor. Further analysis is required to test these options and the ongoing design optimisation of the EP10 diagnostic systems.

  12. Environmental analysis in small and medium enterprises

    International Nuclear Information System (INIS)

    Luciani, R.; Andriola, L.; Di Franco, N.

    2001-01-01

    An environmental analysis is considered to be one of the primary goals for an enterprise environmental management. Nevertheless the complexity of the environmental problems and of its regulations prevents the small enterprises the possibility to perform an environmental policy (EMAS, ISO 14001). One of the most correct evaluation instrument for creating a datum-point standard could be the filling up a questionnaire, built up in according to the industrial enterprises need. It has the function of creating a primary step for a subsequent environmental management [it

  13. Diagnostics of subtropical plants functional state by cluster analysis

    Directory of Open Access Journals (Sweden)

    Oksana Belous

    2016-05-01

    Full Text Available The article presents an application example of statistical methods for data analysis on diagnosis of the adaptive capacity of subtropical plants varieties. We depicted selection indicators and basic physiological parameters that were defined as diagnostic. We used evaluation on a set of parameters of water regime, there are: determination of water deficit of the leaves, determining the fractional composition of water and detection parameters of the concentration of cell sap (CCS (for tea culture flushes. These settings are characterized by high liability and high responsiveness to the effects of many abiotic factors that determined the particular care in the selection of plant material for analysis and consideration of the impact on sustainability. On the basis of the experimental data calculated the coefficients of pair correlation between climatic factors and used physiological indicators. The result was a selection of physiological and biochemical indicators proposed to assess the adaptability and included in the basis of methodical recommendations on diagnostics of the functional state of the studied cultures. Analysis of complex studies involving a large number of indicators is quite difficult, especially does not allow to quickly identify the similarity of new varieties for their adaptive responses to adverse factors, and, therefore, to set general requirements to conditions of cultivation. Use of cluster analysis suggests that in the analysis of only quantitative data; define a set of variables used to assess varieties (and the more sampling, the more accurate the clustering will happen, be sure to ascertain the measure of similarity (or difference between objects. It is shown that the identification of diagnostic features, which are subjected to statistical processing, impact the accuracy of the varieties classification. Selection in result of the mono-clusters analysis (variety tea Kolhida; hazelnut Lombardsky red; variety kiwi Monty

  14. Nuclear analysis techniques and environmental sciences

    International Nuclear Information System (INIS)

    1997-10-01

    31 theses are collected in this book. It introduced molecular activation analysis micro-PIXE and micro-probe analysis, x-ray fluorescence analysis and accelerator mass spectrometry. The applications about these nuclear analysis techniques are presented and reviewed for environmental sciences

  15. Handbook of Coherent-Domain Optical Methods Biomedical Diagnostics, Environmental Monitoring, and Materials Science

    CERN Document Server

    2013-01-01

    This Handbook provides comprehensive coverage of laser and coherent-domain methods as applied to biomedicine, environmental monitoring, and materials science. Worldwide leaders in these fields describe the fundamentals of light interaction with random media and present an overview of basic research. The latest results on coherent and polarization properties of light scattered by random media, including tissues and blood, speckles formation in multiple scattering media, and other non-destructive interactions of coherent light with rough surfaces and tissues, allow the reader to understand the principles and applications of coherent diagnostic techniques. The expanded second edition has been thoroughly updated with particular emphasis on novel coherent-domain techniques and their applications in medicine and environmental science. Volume 1 describes state-of-the-art methods of coherent and polarization optical imaging, tomography and spectroscopy; diffusion wave spectroscopy; elastic, quasi-elastic and inelasti...

  16. Oligonucleotide-based biosensors for in vitro diagnostics and environmental hazard detection.

    Science.gov (United States)

    Jung, Il Young; Lee, Eun Hee; Suh, Ah Young; Lee, Seung Jin; Lee, Hyukjin

    2016-04-01

    Oligonucleotide-based biosensors have drawn much attention because of their broad applications in in vitro diagnostics and environmental hazard detection. They are particularly of interest to many researchers because of their high specificity as well as excellent sensitivity. Recently, oligonucleotide-based biosensors have been used to achieve not only genetic detection of targets but also the detection of small molecules, peptides, and proteins. This has further broadened the applications of these sensors in the medical and health care industry. In this review, we highlight various examples of oligonucleotide-based biosensors for the detection of diseases, drugs, and environmentally hazardous chemicals. Each example is provided with detailed schematics of the detection mechanism in addition to the supporting experimental results. Furthermore, future perspectives and new challenges in oligonucleotide-based biosensors are discussed.

  17. Bayesian tomography and integrated data analysis in fusion diagnostics

    Science.gov (United States)

    Li, Dong; Dong, Y. B.; Deng, Wei; Shi, Z. B.; Fu, B. Z.; Gao, J. M.; Wang, T. B.; Zhou, Yan; Liu, Yi; Yang, Q. W.; Duan, X. R.

    2016-11-01

    In this article, a Bayesian tomography method using non-stationary Gaussian process for a prior has been introduced. The Bayesian formalism allows quantities which bear uncertainty to be expressed in the probabilistic form so that the uncertainty of a final solution can be fully resolved from the confidence interval of a posterior probability. Moreover, a consistency check of that solution can be performed by checking whether the misfits between predicted and measured data are reasonably within an assumed data error. In particular, the accuracy of reconstructions is significantly improved by using the non-stationary Gaussian process that can adapt to the varying smoothness of emission distribution. The implementation of this method to a soft X-ray diagnostics on HL-2A has been used to explore relevant physics in equilibrium and MHD instability modes. This project is carried out within a large size inference framework, aiming at an integrated analysis of heterogeneous diagnostics.

  18. Diagnostic markers of urothelial cancer based on DNA methylation analysis

    International Nuclear Information System (INIS)

    Chihara, Yoshitomo; Hirao, Yoshihiko; Kanai, Yae; Fujimoto, Hiroyuki; Sugano, Kokichi; Kawashima, Kiyotaka; Liang, Gangning; Jones, Peter A; Fujimoto, Kiyohide; Kuniyasu, Hiroki

    2013-01-01

    Early detection and risk assessment are crucial for treating urothelial cancer (UC), which is characterized by a high recurrence rate, and necessitates frequent and invasive monitoring. We aimed to establish diagnostic markers for UC based on DNA methylation. In this multi-center study, three independent sample sets were prepared. First, DNA methylation levels at CpG loci were measured in the training sets (tumor samples from 91 UC patients, corresponding normal-appearing tissue from these patients, and 12 normal tissues from age-matched bladder cancer-free patients) using the Illumina Golden Gate methylation assay to identify differentially methylated loci. Next, these methylated loci were validated by quantitative DNA methylation by pyrosequencing, using another cohort of tissue samples (Tissue validation set). Lastly, methylation of these markers was analyzed in the independent urine samples (Urine validation set). ROC analysis was performed to evaluate the diagnostic accuracy of these 12 selected markers. Of the 1303 CpG sites, 158 were hyper ethylated and 356 were hypo ethylated in tumor tissues compared to normal tissues. In the panel analysis, 12 loci showed remarkable alterations between tumor and normal samples, with 94.3% sensitivity and 97.8% specificity. Similarly, corresponding normal tissue could be distinguished from normal tissues with 76.0% sensitivity and 100% specificity. Furthermore, the diagnostic accuracy for UC of these markers determined in urine samples was high, with 100% sensitivity and 100% specificity. Based on these preliminary findings, diagnostic markers based on differential DNA methylation at specific loci can be useful for non-invasive and reliable detection of UC and epigenetic field defect

  19. Environmental Management Strategy: Four Forces Analysis

    Science.gov (United States)

    Doyle, Martin W.; Von Windheim, Jesko

    2015-01-01

    We develop an analytical approach for more systematically analyzing environmental management problems in order to develop strategic plans. This approach can be deployed by agencies, non-profit organizations, corporations, or other organizations and institutions tasked with improving environmental quality. The analysis relies on assessing the underlying natural processes followed by articulation of the relevant societal forces causing environmental change: (1) science and technology, (2) governance, (3) markets and the economy, and (4) public behavior. The four forces analysis is then used to strategize which types of actions might be most effective at influencing environmental quality. Such strategy has been under-used and under-valued in environmental management outside of the corporate sector, and we suggest that this four forces analysis is a useful analytic to begin developing such strategy.

  20. Environmental management strategy: four forces analysis.

    Science.gov (United States)

    Doyle, Martin W; Von Windheim, Jesko

    2015-01-01

    We develop an analytical approach for more systematically analyzing environmental management problems in order to develop strategic plans. This approach can be deployed by agencies, non-profit organizations, corporations, or other organizations and institutions tasked with improving environmental quality. The analysis relies on assessing the underlying natural processes followed by articulation of the relevant societal forces causing environmental change: (1) science and technology, (2) governance, (3) markets and the economy, and (4) public behavior. The four forces analysis is then used to strategize which types of actions might be most effective at influencing environmental quality. Such strategy has been under-used and under-valued in environmental management outside of the corporate sector, and we suggest that this four forces analysis is a useful analytic to begin developing such strategy.

  1. 23 CFR 710.305 - Environmental analysis.

    Science.gov (United States)

    2010-04-01

    ... FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RIGHT-OF-WAY AND ENVIRONMENT RIGHT-OF-WAY AND REAL ESTATE Project Development § 710.305 Environmental analysis. The National Environmental Policy Act... agreement for acquisition of right-of-way. Where applicable, a State also must complete Clean Air Act (42 U...

  2. CAD-Based Shielding Analysis for ITER Port Diagnostics

    Directory of Open Access Journals (Sweden)

    Serikov Arkady

    2017-01-01

    Full Text Available Radiation shielding analysis conducted in support of design development of the contemporary diagnostic systems integrated inside the ITER ports is relied on the use of CAD models. This paper presents the CAD-based MCNP Monte Carlo radiation transport and activation analyses for the Diagnostic Upper and Equatorial Port Plugs (UPP #3 and EPP #8, #17. The creation process of the complicated 3D MCNP models of the diagnostics systems was substantially accelerated by application of the CAD-to-MCNP converter programs MCAM and McCad. High performance computing resources of the Helios supercomputer allowed to speed-up the MCNP parallel transport calculations with the MPI/OpenMP interface. The found shielding solutions could be universal, reducing ports R&D costs. The shield block behind the Tritium and Deposit Monitor (TDM optical box was added to study its influence on Shut-Down Dose Rate (SDDR in Port Interspace (PI of EPP#17. Influence of neutron streaming along the Lost Alpha Monitor (LAM on the neutron energy spectra calculated in the Tangential Neutron Spectrometer (TNS of EPP#8. For the UPP#3 with Charge eXchange Recombination Spectroscopy (CXRS-core, an excessive neutron streaming along the CXRS shutter, which should be prevented in further design iteration.

  3. CAD-Based Shielding Analysis for ITER Port Diagnostics

    Science.gov (United States)

    Serikov, Arkady; Fischer, Ulrich; Anthoine, David; Bertalot, Luciano; De Bock, Maartin; O'Connor, Richard; Juarez, Rafael; Krasilnikov, Vitaly

    2017-09-01

    Radiation shielding analysis conducted in support of design development of the contemporary diagnostic systems integrated inside the ITER ports is relied on the use of CAD models. This paper presents the CAD-based MCNP Monte Carlo radiation transport and activation analyses for the Diagnostic Upper and Equatorial Port Plugs (UPP #3 and EPP #8, #17). The creation process of the complicated 3D MCNP models of the diagnostics systems was substantially accelerated by application of the CAD-to-MCNP converter programs MCAM and McCad. High performance computing resources of the Helios supercomputer allowed to speed-up the MCNP parallel transport calculations with the MPI/OpenMP interface. The found shielding solutions could be universal, reducing ports R&D costs. The shield block behind the Tritium and Deposit Monitor (TDM) optical box was added to study its influence on Shut-Down Dose Rate (SDDR) in Port Interspace (PI) of EPP#17. Influence of neutron streaming along the Lost Alpha Monitor (LAM) on the neutron energy spectra calculated in the Tangential Neutron Spectrometer (TNS) of EPP#8. For the UPP#3 with Charge eXchange Recombination Spectroscopy (CXRS-core), an excessive neutron streaming along the CXRS shutter, which should be prevented in further design iteration.

  4. Comparative analysis of diagnostic accuracy of different brain biopsy procedures.

    Science.gov (United States)

    Jain, Deepali; Sharma, Mehar Chand; Sarkar, Chitra; Gupta, Deepak; Singh, Manmohan; Mahapatra, A K

    2006-12-01

    Image-guided procedures such as computed tomography (CT) guided, neuronavigator-guided and ultrasound-guided methods can assist neurosurgeons in localizing the intraparenchymal lesion of the brain. However, despite improvements in the imaging techniques, an accurate diagnosis of intrinsic lesion requires tissue sampling and histological verification. The present study was carried out to examine the reliability of the diagnoses made on tumor sample obtained via different stereotactic and ultrasound-guided brain biopsy procedures. A retrospective analysis was conducted of all brain biopsies (frame-based and frameless stereotactic and ultrasound-guided) performed in a single tertiary care neurosciences center between 1995 and 2005. The overall diagnostic accuracy achieved on histopathology and correlation with type of biopsy technique was evaluated. A total of 130 cases were included, which consisted of 82 males and 48 females. Age ranged from 4 to 75 years (mean age 39.5 years). Twenty per cent (27 patients) were in the pediatric age group, while 12% (16 patients) were >or= 60-years of age. A definitive histological diagnosis was established in 109 cases (diagnostic yield 80.2%), which encompassed 101 neoplastic and eight nonneoplastic lesions. Frame-based, frameless stereotactic and ultrasound-guided biopsies were done in 95, 15 and 20 patients respectively. Although the numbers of cases were small there was trend for better yield with frameless image-guided stereotactic biopsy and maximum diagnostic yield was obtained i.e, 87% (13/15) in comparison to conventional frame-based CT-guided stereotactic biopsy and ultrasound-guided biopsy. Overall, a trend of higher diagnostic yield was seen in cases with frameless image-guided stereotactic biopsy. Thus, this small series confirms that frameless neuronavigator-guided stereotactic procedures represent the lesion sufficiently in order to make histopathologic diagnosis.

  5. Aquifer test interpretation using derivative analysis and diagnostic plots

    Science.gov (United States)

    Hernández-Espriú, Antonio; Real-Rangel, Roberto; Cortés-Salazar, Iván; Castro-Herrera, Israel; Luna-Izazaga, Gabriela; Sánchez-León, Emilio

    2017-04-01

    Pumping tests remain a method of choice to deduce fundamental aquifer properties and to assess well condition. In the oil and gas (O&G) industry, well testing has been the core technique in examining reservoir behavior over the last 50 years. The pressure derivative by Bourdet, it is perhaps, the most significant single development in the history of well test analysis. Recently, the so-called diagnostics plots (e.g. drawdown and drawdown derivative in a log-log plot) have been successfully tested in aquifers. However, this procedure is still underutilized by groundwater professionals. This research illustrates the applicability range, advantages and drawbacks (e.g. smoothing procedures) of diagnostic plots using field examples from a wide spectrum of tests (short/long tests, constant/variable flow rates, drawdown/buildup stages, pumping well/observation well) in dissimilar geological conditions. We analyze new and pre-existent aquifer tests in Mexico, USA, Canada, Germany, France and Saudi Arabia. In constant flow rate tests, our results show that derivative analysis is an easy, robust and powerful tool to assess near-borehole damage effects, formation heterogeneity, boundaries, flow regimes, infinite-acting radial stages, i.e., valid Theisian framework, and fracture-driven flow. In step tests, the effectiveness relies on high-frequency drawdown measurements. Moreover, we adapt O&G analytical solutions to cater for the conditions in groundwater systems. In this context, further parameters can be computed analytically from the plots, such as skin factor, head losses, wellbore storage, distance to the boundary, channel-aquifer and/or fracture zone width, among others. Therefore, diagnostic plots should be considered a mandatory tool for pumping tests analysis among hydrogeologists. This project has been supported by DGAPA (UNAM) under the research project PAPIIT IN-112815.

  6. Comparing Distributions of Environmental Outcomes for Regulatory Environmental Justice Analysis

    Directory of Open Access Journals (Sweden)

    Glenn Sheriff

    2011-05-01

    Full Text Available Economists have long been interested in measuring distributional impacts of policy interventions. As environmental justice (EJ emerged as an ethical issue in the 1970s, the academic literature has provided statistical analyses of the incidence and causes of various environmental outcomes as they relate to race, income, and other demographic variables. In the context of regulatory impacts, however, there is a lack of consensus regarding what information is relevant for EJ analysis, and how best to present it. This paper helps frame the discussion by suggesting a set of questions fundamental to regulatory EJ analysis, reviewing past approaches to quantifying distributional equity, and discussing the potential for adapting existing tools to the regulatory context.

  7. Full spectrum analysis in environmental monitoring

    International Nuclear Information System (INIS)

    Reinhardt, Sascha; Hartmann, Soeren; Pimpl, Richard

    2015-01-01

    In the environmental monitoring spectroscopic gamma detectors are frequently used. The motivation to use spectroscopic gamma detectors is the higher sensitivity and specific spectral information. For the analysis often the photo peaks of the gamma spectrum are used to identify the nuclide. These methods are very reliable, robust and well developed but using only the photo peak means also to use only a fraction of the available information. Doing a full spectrum analysis based on principle components obtained from NASVD for description of the radiation background and adjustment calculations are a possible analysis method which may provide advantages compared to a peak based analysis when used for a continuous environmental monitoring. An analysis example is shown and discussed with a measured time series of gamma spectra obtained from a spectroscopic gamma detector SARA IGS710 with a NaI(Tl) scintillator as it is used in the environmental monitoring.

  8. Full spectrum analysis in environmental monitoring

    International Nuclear Information System (INIS)

    Reinahrdt, S.; Hartmann, S.; Pimpl, R.

    2014-01-01

    In the environmental monitoring spectroscopic gamma detectors are frequently used. The motivation to use spectroscopic gamma detectors is the higher sensitivity and specific spectral information. For the analysis often the photo peaks of the gamma spectrum are used to identify the nuclide. These methods are very reliable, robust and well developed but using only the photo peak means also to use only a fraction of the available information. Doing a full spectrum analysis based on principal components obtained from NASVD for description of the radiation background and adjustment calculations are a possible analysis method, which may provide advantages compared to a peak based analysis when used for a continuous environmental monitoring. An analysis example is shown and discussed with a measured time series of gamma spectra obtained from a spectroscopic gamma detector SARA IGS710 with a NaI(Tl) scintillator as it is used in the environmental monitoring. (authors)

  9. Data analysis and interpretation for environmental surveillance

    International Nuclear Information System (INIS)

    1992-06-01

    The Data Analysis and Interpretation for Environmental Surveillance Conference was held in Lexington, Kentucky, February 5--7, 1990. The conference was sponsored by what is now the Office of Environmental Compliance and Documentation, Oak Ridge National Laboratory. Participants included technical professionals from all Martin Marietta Energy Systems facilities, Westinghouse Materials Company of Ohio, Pacific Northwest Laboratory, and several technical support contractors. Presentations at the conference ranged the full spectrum of issues that effect the analysis and interpretation of environmental data. Topics included tracking systems for samples and schedules associated with ongoing programs; coalescing data from a variety of sources and pedigrees into integrated data bases; methods for evaluating the quality of environmental data through empirical estimates of parameters such as charge balance, pH, and specific conductance; statistical applications to the interpretation of environmental information; and uses of environmental information in risk and dose assessments. Hearing about and discussing this wide variety of topics provided an opportunity to capture the subtlety of each discipline and to appreciate the continuity that is required among the disciplines in order to perform high-quality environmental information analysis

  10. Analysis procedure for americium in environmental samples

    International Nuclear Information System (INIS)

    Holloway, R.W.; Hayes, D.W.

    1982-01-01

    Several methods for the analysis of 241 Am in environmental samples were evaluated and a preferred method was selected. This method was modified and used to determine the 241 Am content in sediments, biota, and water. The advantages and limitations of the method are discussed. The method is also suitable for 244 Cm analysis

  11. Febrile illness diagnostics and the malaria-industrial complex: a socio-environmental perspective

    Directory of Open Access Journals (Sweden)

    Justin Stoler

    2016-11-01

    Full Text Available Abstract Background Global prioritization of single-disease eradication programs over improvements to basic diagnostic capacity in the Global South have left the world unprepared for epidemics of chikungunya, Ebola, Zika, and whatever lies on the horizon. The medical establishment is slowly realizing that in many parts of sub-Saharan Africa (SSA, particularly urban areas, up to a third of patients suffering from acute fever do not receive a correct diagnosis of their infection. Main body Malaria is the most common diagnosis for febrile patients in low-resource health care settings, and malaria misdiagnosis has soared due to the institutionalization of malaria as the primary febrile illness of SSA by international development organizations and national malaria control programs. This has inadvertently created a “malaria-industrial complex” and historically obstructed our complete understanding of the continent’s complex communicable disease epidemiology, which is currently dominated by a mélange of undiagnosed febrile illnesses. We synthesize interdisciplinary literature from Ghana to highlight the complexity of communicable disease care in SSA from biomedical, social, and environmental perspectives, and suggest a way forward. Conclusion A socio-environmental approach to acute febrile illness etiology, diagnostics, and management would lead to substantial health gains in Africa, including more efficient malaria control. Such an approach would also improve global preparedness for future epidemics of emerging pathogens such as chikungunya, Ebola, and Zika, all of which originated in SSA with limited baseline understanding of their epidemiology despite clinical recognition of these viruses for many decades. Impending ACT resistance, new vaccine delays, and climate change all beckon our attention to proper diagnosis of fevers in order to maximize limited health care resources.

  12. Isotope dilution analysis of environmental samples

    International Nuclear Information System (INIS)

    Tolgyessy, J.; Lesny, J.; Korenova, Z.; Klas, J.; Klehr, E.H.

    1986-01-01

    Isotope dilution analysis has been used for the determination of several trace elements - especially metals - in a variety of environmental samples, including aerosols, water, soils, biological materials and geological materials. Variations of the basic concept include classical IDA, substoichiometric IDA, and more recently, sub-superequivalence IDA. Each variation has its advantages and limitations. A periodic chart has been used to identify those elements which have been measured in environmental samples using one or more of these methods. (author)

  13. Electric probe data analysis for glow discharge diagnostics

    International Nuclear Information System (INIS)

    Cain, B.L.

    1987-01-01

    This report summarizes the development and application of digital computations for the analysis of data from an electric probe used for glow discharge diagnostics. The essential physics of the probe/discharge interaction is presented, along with formulations from modern electric probe theory. These results are then digitally implemented by a set of computer programs which both calculate discharge properties of electron temperature and density, and aid in the interpretation of these property estimates. The method of analysis, and the theories selected for implementation, are valid only for low pressure, collisionless sheath, and quiescent discharges where the single electric probe has a much smaller area than the discharge reference electrode. However, certain algorithms are included which, in some cases, can extend the analysis into intermediate pressure regimes. The digital programs' functional capabilities are demonstrated by the analysis of experimental probe data, collected using a laboratory glow discharge. Typical sources of error inherent in the electric probe method are discussed, along with an analysis of error induced by the computational methods of the programs. 27 refs., 49 figs., 20 tabs

  14. Participation of the IPEN/CNEN/SP Environmental Diagnostic Division on programs of laboratory intercomparisons in environmental samples

    International Nuclear Information System (INIS)

    Cotrim, Marycel Barboza; Sato, Ivone Mulako; Salvador, Vera Lucia R.; Dantas, Elizabeth Sonoda Keiko; Cantagallo, Maria Ines; Lemes, Marcos Jose L.; Scapin, Marcos Antonio; Sisti, Cristina; Silveira, Elias Santana; Furusawa, Helio Akira; Pires, Maria Aparecida Faustino

    2003-01-01

    The present work presents the participation of the Environmental Diagnostic Division Laboratories (MQA) at the intercomparison national and international laboratories, (PI/SABESP - Interlaboratory Sao Paulo, Brazil, Program; Program for Interlaboratorial Analytic Quality Control of Metals in Water (CBM/COMETRO); Programa para La Calidad de las Mediciones Quimicas (PCQM/INTI) - Argentine, and the Commission d'Etablissement des Methodes d'Analyse, France (CETAMA/CEA). Those essay providers have using statistical tests such as the t-Student, Zscore and Cochran and Grubbs for the data evaluations. The obtained results are presented involving the analytical such as atomic absorption spectrometry: flame, graphite oven and hydride generation (AAS), emission spectrometry with induced plasma (ICP-OES), X-ray fluorescence WD-XRFS), ion chromatography and voltametry (VRA). The elements such as B, Al, K, Mg, Ca, Cr, Fe, Co, Cu, Zn and Pb, and the anions such as Cl-, NO 3 - , SO 4 2- and F - , were determined at trace level (mgL -1 ), and the elements such as Cr, As, Cd, Pb e Hg, at the trace level (μgL -1 ) in water matrices. The evaluation of analytical results, in the period 1997 to 2002, demonstrate a continuous improvement evidencing the importance of Laboratories participation at those type of exercises

  15. FISH analysis for diagnostic evaluation of challenging melanocytic lesions.

    Science.gov (United States)

    Zimmermann, A K; Hirschmann, A; Pfeiffer, D; Paredes, B E; Diebold, J

    2010-09-01

    The differential diagnosis of malignant melanomas and atypical melanocytic nevi is still a diagnostic challenge. The currently accepted morphologic criteria show substantial interobserver variability, likewise immunohistochemical studies are often not able to discriminate these lesions reliably. Techniques that support diagnostic accuracy are of the greatest importance considering the growing incidence of malignant melanomas and their increase in younger patients. In this study we analyzed the feasibility of fluorescence in situ hybridization (FISH) analysis for the discrimination of malignant and benign melanocytic tumors. A panel of DNA probes was used to detect chromosomal aberrations of chromosomes 6 and 11. On a series of 5 clearly malignant and benign melanocytic tumors we confirmed the applicability of the test. Then we focused on examination of ambiguous melanocytic lesions, where atypical cells are often difficult to relocalize in the 4',6-Diamidino-2-phenylindol (DAPI)-fluorescence stain. FISH analyses were conducted on destained H&E-stained slides. By comparison of the DAPI-image with photos taken from the H&E stain, unambiguous assignment of the FISH results to the conspicuous groups of cells was possible. The results of FISH analysis were consistent with the conventional diagnosis in 11 of 14 small ambiguous lesions. Of the remaining 3 cases, 2 showed FISH-results close to the cut-off level. Comparison of FISH results on thin and thick sections revealed that the cut-off values have to be adapted for 2 microm destained sections. In conclusion, FISH analysis is a useful and applicable tool for assessment of even smallest melanocytic neoplasms, although there will remain unclear cases that cannot be solved even after additional FISH evaluation.

  16. Environmentally based Cost-Benefit Analysis

    International Nuclear Information System (INIS)

    Magnell, M.

    1993-11-01

    The fundamentals of the basic elements of a new comprehensive economic assessment, MILA, developed in Sweden with inspiration from the Total Cost Assessment-model are presented. The core of the MILA approach is an expanded cost and benefit inventory. But MILA also includes a complementary addition of an internal waste stream analysis, a tool for evaluation of environmental conflicts in monetary terms, an extended time horizon and direct allocation of costs and revenues to products and processes. However, MILA does not ensure profitability for environmentally sound projects. Essentially, MILA is an approach of refining investment and profitability analysis of a project, investment or product. 109 refs., 38 figs

  17. Tissue preservation with mass spectroscopic analysis: Implications for cancer diagnostics.

    Science.gov (United States)

    Hall, O Morgan; Peer, Cody J; Figg, William D

    2018-05-17

    Surgical intervention is a common treatment modality for localized cancer. Post-operative analysis involves evaluation of surgical margins to assess whether all malignant tissue has been resected because positive surgical margins lead to a greater likelihood of recurrence. Secondary treatments are utilized to minimize the negative effects of positive surgical margins. Recently, in Science Translational Medicine, Zhang et al describe a new mass spectroscopic technique that could potentially decrease the likelihood of positive surgical margins. Their nondestructive in vivo tissue sampling leads to a highly accurate and rapid cancer diagnosis with great precision between healthy and malignant tissue. This new tool has the potential to improve surgical margins and accelerate cancer diagnostics by analyzing biomolecular signatures of various tissues and diseases.

  18. Conditional Probability Analysis: A Statistical Tool for Environmental Analysis.

    Science.gov (United States)

    The use and application of environmental conditional probability analysis (CPA) is relatively recent. The first presentation using CPA was made in 2002 at the New England Association of Environmental Biologists Annual Meeting in Newport. Rhode Island. CPA has been used since the...

  19. Computerized diagnostic data analysis and 3-D visualization

    International Nuclear Information System (INIS)

    Schuhmann, D.; Haubner, M.; Krapichler, C.; Englmeier, K.H.; Seemann, M.; Schoepf, U.J.; Gebicke, K.; Reiser, M.

    1998-01-01

    Purpose: To survey methods for 3D data visualization and image analysis which can be used for computer based diagnostics. Material and methods: The methods available are explained in short terms and links to the literature are presented. Methods which allow basic manipulation of 3D data are windowing, rotation and clipping. More complex methods for visualization of 3D data are multiplanar reformation, volume projections (MIP, semi-transparent projections) and surface projections. Methods for image analysis comprise local data transformation (e.g. filtering) and definition and application of complex models (e.g. deformable models). Results: Volume projections produce an impression of the 3D data set without reducing the data amount. This supports the interpretation of the 3D data set and saves time in comparison to any investigation which requires examination of all slice images. More advanced techniques for visualization, e.g. surface projections and hybrid rendering visualize anatomical information to a very detailed extent, but both techniques require the segmentation of the structures of interest. Image analysis methods can be used to extract these structures (e.g. an organ) from the image data. Discussion: At the present time volume projections are robust and fast enough to be used routinely. Surface projections can be used to visualize complex and presegmented anatomical features. (orig.) [de

  20. Flotation process diagnostics and modelling by coal grain analysis

    Energy Technology Data Exchange (ETDEWEB)

    Ofori, P; O' Brien, G.; Firth, B.; Jenkins, B. [CSIRO Energy Technology, Brisbane, Qld. (Australia)

    2006-05-15

    In coal flotation, particles of different components of the coal such as maceral groups and mineral matter and their associations have different hydrophobicities and therefore different flotation responses. By using a new coal grain analysis method for characterising individual grains, more detailed flotation performance analysis and modelling approaches have been developed. The method involves the use of microscopic imaging techniques to obtain estimates of size, compositional and density information on individual grains of fine coal. The density and composition partitioning of coal processed through different flotation systems provides an avenue to pinpoint the actual cause of poor process performance so that corrective action may be initiated. The information on grain size, density and composition is being used as input data to develop more detailed flotation process models to provide better predictions of process performance for both mechanical and column flotation devices. A number of approaches may be taken to flotation modelling such as the probability approach and the kinetic model approach or a combination of the two. In the work reported here, a simple probability approach has been taken, which will be further refined in due course. The use of grain data to map the responses of different types of coal grains through various fine coal cleaning processes provided a more advanced diagnostic capability for fine coal cleaning circuits. This enabled flotation performance curves analogous to partition curves for density separators to be produced for flotation devices.

  1. System diagnostics using qualitative analysis and component functional classification

    International Nuclear Information System (INIS)

    Reifman, J.; Wei, T.Y.C.

    1993-01-01

    A method for detecting and identifying faulty component candidates during off-normal operations of nuclear power plants involves the qualitative analysis of macroscopic imbalances in the conservation equations of mass, energy and momentum in thermal-hydraulic control volumes associated with one or more plant components and the functional classification of components. The qualitative analysis of mass and energy is performed through the associated equations of state, while imbalances in momentum are obtained by tracking mass flow rates which are incorporated into a first knowledge base. The plant components are functionally classified, according to their type, as sources or sinks of mass, energy and momentum, depending upon which of the three balance equations is most strongly affected by a faulty component which is incorporated into a second knowledge base. Information describing the connections among the components of the system forms a third knowledge base. The method is particularly adapted for use in a diagnostic expert system to detect and identify faulty component candidates in the presence of component failures and is not limited to use in a nuclear power plant, but may be used with virtually any type of thermal-hydraulic operating system. 5 figures

  2. Characterizing the intrinsic bioremediation potential of 1,4-dioxane and trichloroethene using innovative environmental diagnostic tools.

    Science.gov (United States)

    Chiang, Sheau-Yun Dora; Mora, Rebecca; Diguiseppi, William H; Davis, Greg; Sublette, Kerry; Gedalanga, Phillip; Mahendra, Shaily

    2012-09-01

    An intrinsic biodegradation study involving the design and implementation of innovative environmental diagnostic tools was conducted to evaluate whether monitored natural attenuation (MNA) could be considered as part of the remedial strategy to treat an aerobic aquifer contaminated with 1,4-dioxane and trichloroethene (TCE). In this study, advanced molecular biological and stable isotopic tools were applied to confirm in situ intrinsic biodegradation of 1,4-dioxane and TCE. Analyses of Bio-Trap® samplers and groundwater samples collected from monitoring wells verified the abundance of bacteria and enzymes capable of aerobically degrading TCE and 1,4-dioxane. Furthermore, phospholipid fatty acid analysis with stable isotope probes (PLFA-SIP) of the microbial community validated the ability for microbial degradation of TCE and 1,4-dioxane. Compound specific isotope analysis (CSIA) of groundwater samples for TCE resulted in δ(13)C values that indicated likely biodegradation of TCE in three of the four monitoring wells sampled. Results of the MNA evaluation showed that enzymes capable of aerobically degrading TCE and 1,4-dioxane were present, abundant, and active in the aquifer. Taken together, these results provide direct evidence of the occurrence of TCE and 1,4-dioxane biodegradation at the study site, supporting the selection of MNA as part of the final remedy at some point in the future.

  3. Integrating health and environmental impact analysis

    DEFF Research Database (Denmark)

    Reis, S; Morris, G.; Fleming, L. E.

    2015-01-01

    which addresses human activity in all its social, economic and cultural complexity. The new approach must be integral to, and interactive, with the natural environment. We see the continuing failure to truly integrate human health and environmental impact analysis as deeply damaging, and we propose...... while equally emphasizing the health of the environment, and the growing calls for 'ecological public health' as a response to global environmental concerns now suffusing the discourse in public health. More revolution than evolution, ecological public health will demand new perspectives regarding...... the interconnections among society, the economy, the environment and our health and well-being. Success must be built on collaborations between the disparate scientific communities of the environmental sciences and public health as well as interactions with social scientists, economists and the legal profession...

  4. Molecular malaria diagnostics: A systematic review and meta-analysis

    NARCIS (Netherlands)

    Roth, Johanna M.; Korevaar, Daniël A.; Leeflang, Mariska M. G.; Mens, Pètra F.

    2016-01-01

    Accurate diagnosis of malaria is essential for identification and subsequent treatment of the disease. Currently, microscopy and rapid diagnostic tests are the most commonly used diagnostics, next to treatment based on clinical signs only. These tests are easy to deploy, but have a relatively high

  5. Handbook of coherent domain optical methods biomedical diagnostics, environmental and material science

    CERN Document Server

    2004-01-01

    For the first time in one set of books, coherent-domain optical methods are discussed in the framework of various applications, which are characterized by a strong light scattering. A few chapters describe basic research containing the updated results on coherent and polarized light non-destructive interactions with a scattering medium, in particular, diffraction, interference, and speckle formation at multiple scattering. These chapters allow for understanding coherent-domain diagnostic techniques presented in later chapters. A large portion of Volume I is dedicated to analysis of various aspects of optical coherence tomography (OCT) - a very new and growing field of coherent optics. Two chapters on laser scanning confocal microscopy give insight to recent extraordinary results on in vivo imaging and compare the possibilities and achievements of confocol, excitation multiphoton, and OCT microscopy. This two volume reference contains descriptions of holography, interferometry and optical heterodyning techniqu...

  6. Decision analysis to complete diagnostic research by closing the gap between test characteristics and cost-effectiveness

    NARCIS (Netherlands)

    Schaafsma, Joanna D.; van der Graaf, Yolanda; Rinkel, Gabriel J. E.; Buskens, Erik

    2009-01-01

    Objective: The lack of a standard methodology in diagnostic research impedes adequate evaluation before implementation of constantly developing diagnostic techniques. We discuss the methodology of diagnostic research and underscore the relevance of decision analysis in the process of evaluation of

  7. Advanced Diagnostic and Prognostic Testbed (ADAPT) Testability Analysis Report

    Science.gov (United States)

    Ossenfort, John

    2008-01-01

    As system designs become more complex, determining the best locations to add sensors and test points for the purpose of testing and monitoring these designs becomes more difficult. Not only must the designer take into consideration all real and potential faults of the system, he or she must also find efficient ways of detecting and isolating those faults. Because sensors and cabling take up valuable space and weight on a system, and given constraints on bandwidth and power, it is even more difficult to add sensors into these complex designs after the design has been completed. As a result, a number of software tools have been developed to assist the system designer in proper placement of these sensors during the system design phase of a project. One of the key functions provided by many of these software programs is a testability analysis of the system essentially an evaluation of how observable the system behavior is using available tests. During the design phase, testability metrics can help guide the designer in improving the inherent testability of the design. This may include adding, removing, or modifying tests; breaking up feedback loops, or changing the system to reduce fault propagation. Given a set of test requirements, the analysis can also help to verify that the system will meet those requirements. Of course, a testability analysis requires that a software model of the physical system is available. For the analysis to be most effective in guiding system design, this model should ideally be constructed in parallel with these efforts. The purpose of this paper is to present the final testability results of the Advanced Diagnostic and Prognostic Testbed (ADAPT) after the system model was completed. The tool chosen to build the model and to perform the testability analysis with is the Testability Engineering and Maintenance System Designer (TEAMS-Designer). The TEAMS toolset is intended to be a solution to span all phases of the system, from design and

  8. A systematic analysis of commonly used antibodies in cancer diagnostics.

    Science.gov (United States)

    Gremel, Gabriela; Bergman, Julia; Djureinovic, Dijana; Edqvist, Per-Henrik; Maindad, Vikas; Bharambe, Bhavana M; Khan, Wasif Ali Z A; Navani, Sanjay; Elebro, Jacob; Jirström, Karin; Hellberg, Dan; Uhlén, Mathias; Micke, Patrick; Pontén, Fredrik

    2014-01-01

    Immunohistochemistry plays a pivotal role in cancer differential diagnostics. To identify the primary tumour from a metastasis specimen remains a significant challenge, despite the availability of an increasing number of antibodies. The aim of the present study was to provide evidence-based data on the diagnostic power of antibodies used frequently for clinical differential diagnostics. A tissue microarray cohort comprising 940 tumour samples, of which 502 were metastatic lesions, representing tumours from 18 different organs and four non-localized cancer types, was analysed using immunohistochemistry with 27 well-established antibodies used in clinical differential diagnostics. Few antibodies, e.g. prostate-specific antigen and thyroglobulin, showed a cancer type-related sensitivity and specificity of more than 95%. A majority of the antibodies showed a low degree of sensitivity and specificity for defined cancer types. Combinations of antibodies provided limited added value for differential diagnostics of cancer types. The results from analysing 27 diagnostic antibodies on consecutive sections of 940 defined tumours provide a unique repository of data that can empower a more optimal use of clinical immunohistochemistry. Our results highlight the benefit of immunohistochemistry and the unmet need for novel markers to improve differential diagnostics of cancer. © 2013 John Wiley & Sons Ltd.

  9. Software for 3D diagnostic image reconstruction and analysis

    International Nuclear Information System (INIS)

    Taton, G.; Rokita, E.; Sierzega, M.; Klek, S.; Kulig, J.; Urbanik, A.

    2005-01-01

    Recent advances in computer technologies have opened new frontiers in medical diagnostics. Interesting possibilities are the use of three-dimensional (3D) imaging and the combination of images from different modalities. Software prepared in our laboratories devoted to 3D image reconstruction and analysis from computed tomography and ultrasonography is presented. In developing our software it was assumed that it should be applicable in standard medical practice, i.e. it should work effectively with a PC. An additional feature is the possibility of combining 3D images from different modalities. The reconstruction and data processing can be conducted using a standard PC, so low investment costs result in the introduction of advanced and useful diagnostic possibilities. The program was tested on a PC using DICOM data from computed tomography and TIFF files obtained from a 3D ultrasound system. The results of the anthropomorphic phantom and patient data were taken into consideration. A new approach was used to achieve spatial correlation of two independently obtained 3D images. The method relies on the use of four pairs of markers within the regions under consideration. The user selects the markers manually and the computer calculates the transformations necessary for coupling the images. The main software feature is the possibility of 3D image reconstruction from a series of two-dimensional (2D) images. The reconstructed 3D image can be: (1) viewed with the most popular methods of 3D image viewing, (2) filtered and processed to improve image quality, (3) analyzed quantitatively (geometrical measurements), and (4) coupled with another, independently acquired 3D image. The reconstructed and processed 3D image can be stored at every stage of image processing. The overall software performance was good considering the relatively low costs of the hardware used and the huge data sets processed. The program can be freely used and tested (source code and program available at

  10. Nuclear techniques for analysis of environmental samples

    International Nuclear Information System (INIS)

    1986-12-01

    The main purposes of this meeting were to establish the state-of-the-art in the field, to identify new research and development that is required to provide an adequate framework for analysis of environmental samples and to assess needs and possibilities for international cooperation in problem areas. This technical report was prepared on the subject based on the contributions made by the participants. A separate abstract was prepared for each of the 9 papers

  11. Trace-element analysis in environmental sciences

    International Nuclear Information System (INIS)

    Valkovic, V.; Moschini, G.

    1988-01-01

    The use of charged-particle accelerators in trace-element analysis in the field of environmental sciences is described in this article. Nuclear reactions, charged-particle-induced X-ray emission as well as other nuclear and atomic processes can be used individually, or combined, in developing adequate analytical systems. In addition to concentration levels, concentration levels, concentration profiles can be measured, resulting in unique information. Some examples of experiments performed are described together with the suggestions for future measurements [pt

  12. Chest X-ray : a cost-diagnostic benefit analysis

    International Nuclear Information System (INIS)

    Winter, L.H.L.

    1991-01-01

    Although plain chest radiography is one of the most useful diagnostic tools available to the physician, this procedure has not evolved into a consistent method. Two Large Field of View Image Intensifiers (LFOV-II) became available; the large imaging area makes them suitable for chest imaging. Both modalities supply 100 mm images to the radiologist. In this thesis the 'diagnostic benefits and 'costs' of these modalities are evaluated and related to the 'gold' standard (conventional full-size). The emphasis is on diagnostic image quality using phantoms for observer performance qualities. (author). 170 refs.; 21 figs.; 47 tabs

  13. Diagnostic performance of semi-quantitative and quantitative stress CMR perfusion analysis: a meta-analysis.

    Science.gov (United States)

    van Dijk, R; van Assen, M; Vliegenthart, R; de Bock, G H; van der Harst, P; Oudkerk, M

    2017-11-27

    Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high spatial resolution and absence of radiation. Semi-quantitative and quantitative analysis of CMR perfusion are based on signal-intensity curves produced during the first-pass of gadolinium contrast. Multiple semi-quantitative and quantitative parameters have been introduced. Diagnostic performance of these parameters varies extensively among studies and standardized protocols are lacking. This study aims to determine the diagnostic accuracy of semi- quantitative and quantitative CMR perfusion parameters, compared to multiple reference standards. Pubmed, WebOfScience, and Embase were systematically searched using predefined criteria (3272 articles). A check for duplicates was performed (1967 articles). Eligibility and relevance of the articles was determined by two reviewers using pre-defined criteria. The primary data extraction was performed independently by two researchers with the use of a predefined template. Differences in extracted data were resolved by discussion between the two researchers. The quality of the included studies was assessed using the 'Quality Assessment of Diagnostic Accuracy Studies Tool' (QUADAS-2). True positives, false positives, true negatives, and false negatives were subtracted/calculated from the articles. The principal summary measures used to assess diagnostic accuracy were sensitivity, specificity, andarea under the receiver operating curve (AUC). Data was pooled according to analysis territory, reference standard and perfusion parameter. Twenty-two articles were eligible based on the predefined study eligibility criteria. The pooled diagnostic accuracy for segment-, territory- and patient-based analyses showed good diagnostic performance with sensitivity of 0.88, 0.82, and 0.83, specificity of 0.72, 0.83, and 0.76 and AUC of 0.90, 0.84, and 0.87, respectively. In per territory

  14. Molecular malaria diagnostics: A systematic review and meta-analysis.

    Science.gov (United States)

    Roth, Johanna M; Korevaar, Daniël A; Leeflang, Mariska M G; Mens, Pètra F

    2016-01-01

    Accurate diagnosis of malaria is essential for identification and subsequent treatment of the disease. Currently, microscopy and rapid diagnostic tests are the most commonly used diagnostics, next to treatment based on clinical signs only. These tests are easy to deploy, but have a relatively high detection limit. With declining prevalence in many areas, there is an increasing need for more sensitive diagnostics. Molecular tools may be a suitable alternative, although costs and technical requirements currently hamper their implementation in resource limited settings. A range of (near) point-of-care diagnostics is therefore under development, including simplifications in sample preparation, amplification and/or read-out of the test. Accuracy data, in combination with technical characteristics, are essential in determining which molecular test, if any, would be the most promising to be deployed. This review presents a comprehensive overview of the currently available molecular malaria diagnostics, ranging from well-known tests to platforms in early stages of evaluation, and systematically evaluates their published accuracy. No important difference in accuracy was found between the most commonly used PCR-based assays (conventional, nested and real-time PCR), with most of them having high sensitivity and specificity, implying that there are no reasons other than practical ones to choose one technique over the other. Loop-mediated isothermal amplification and other (novel) diagnostics appear to be highly accurate as well, with some offering potential to be used in resource-limited settings.

  15. Environmental systems analysis of wastewater management

    International Nuclear Information System (INIS)

    Kaerrman, Erik

    2000-01-01

    The history of wastewater management tells us that efforts have been made at solving only one problem at the time; sanitation during the first half of the 20th Century followed by eutrophication of lakes and sea and, for the past ten years, recycling of nutrients. After the 'Brundtland Report', 1987, a reversal of the debate occurred where water management was discussed in a more holistic manner than before. The concept sustainable development became widely accepted and was put into practice. This thesis suggests a framework for evaluating the sustainability of wastewater systems, which contains the use of criteria and system analytical evaluation methods matching each criterion. The main categories of criteria are identified as: Health and Hygiene, Social and Cultural, Environmental, Economic and Functional and Technical. The usability of different concepts of Environmental Systems Analysis for evaluating environmental criteria of wastewater systems is also investigated. These studies show that a substance-flow model combined with evaluation methods from Life Cycle Assessment (LCA), sometimes complemented with Exergy Analysis or Analysis of Primary Energy, is a beneficial approach for evaluating environmental impacts and the usage of resources. The substance-flow model ORWARE (ORganic WAste REsearch) combined with LCA was used to compare four systems structures for the management of household wastewater and solid organic waste, namely Conventional System, Irrigation of Energy Forests, Liquid Composting and Urine Separation. This study shows a potential for further development of the three alternative systems. The comparative study also included some development of system analytical methods. This thesis shows how the contribution from oxidation of ammonia should be included in the eutrophication impact category. Furthermore, a method is given for prioritization of the most relevant impacts from wastewater management by using normalisation of these impacts in

  16. Analysis of DOE international environmental management activities

    Energy Technology Data Exchange (ETDEWEB)

    Ragaini, R.C.

    1995-09-01

    The Department of Energy`s (DOE) Strategic Plan (April 1994) states that DOE`s long-term vision includes world leadership in environmental restoration and waste management activities. The activities of the DOE Office of Environmental Management (EM) can play a key role in DOE`s goals of maintaining U.S. global competitiveness and ensuring the continuation of a world class science and technology community. DOE`s interest in attaining these goals stems partly from its participation in organizations like the Trade Policy Coordinating Committee (TPCC), with its National Environmental Export Promotion Strategy, which seeks to strengthen U.S. competitiveness and the building of public-private partnerships as part of U.S. industrial policy. The International Interactions Field Office task will build a communication network which will facilitate the efficient and effective communication between DOE Headquarters, Field Offices, and contractors. Under this network, Headquarters will provide the Field Offices with information on the Administration`s policies and activities (such as the DOE Strategic Plan), interagency activities, as well as relevant information from other field offices. Lawrence Livermore National Laboratory (LLNL) will, in turn, provide Headquarters with information on various international activities which, when appropriate, will be included in reports to groups like the TPCC and the EM Focus Areas. This task provides for the collection, review, and analysis of information on the more significant international environmental restoration and waste management initiatives and activities which have been used or are being considered at LLNL. Information gathering will focus on efforts and accomplishments in meeting the challenges of providing timely and cost effective cleanup of its environmentally damaged sites and facilities, especially through international technical exchanges and/or the implementation of foreign-development technologies.

  17. Integrated data analysis of fusion diagnostics by means of the Bayesian probability theory

    International Nuclear Information System (INIS)

    Fischer, R.; Dinklage, A.

    2004-01-01

    Integrated data analysis (IDA) of fusion diagnostics is the combination of heterogeneous diagnostics to obtain validated physical results. Benefits from the integrated approach result from a systematic use of interdependencies; in that sense IDA optimizes the extraction of information from sets of different data. For that purpose IDA requires a systematic and formalized error analysis of all (statistical and systematic) uncertainties involved in each diagnostic. Bayesian probability theory allows for a systematic combination of all information entering the diagnostic model by considering all uncertainties of the measured data, the calibration measurements, and the physical model. Prior physics knowledge on model parameters can be included. Handling of systematic errors is provided. A central goal of the integration of redundant or complementary diagnostics is to provide information to resolve inconsistencies by exploiting interdependencies. A comparable analysis of sets of diagnostics (meta-diagnostics) is performed by combining statistical and systematical uncertainties with model parameters and model uncertainties. Diagnostics improvement and experimental optimization and design of meta-diagnostics will be discussed

  18. Stripping voltammetry in environmental and food analysis.

    Science.gov (United States)

    Brainina, K Z; Malakhova, N A; Stojko, N Y

    2000-10-01

    The review covers over 230 papers published mostly in the last 5 years. The goal of the review is to attract the attention of researchers and users to stripping voltammetry in particular, its application in environmental monitoring and analysis of foodstuffs. The sensors employed are impregnated graphite, carbon paste, thick film carbon/graphite and thin film metallic electrodes modified in-situ or beforehand. Hanging mercury drop electrodes and mercury coated glassy carbon electrodes are also mentioned. Strip and long-lived sensors for portable instruments and flow through systems are discussed as devices for future development and application of stripping voltammetry.

  19. Evaluation of Analysis by Cross-Validation, Part II: Diagnostic and Optimization of Analysis Error Covariance

    Directory of Open Access Journals (Sweden)

    Richard Ménard

    2018-02-01

    Full Text Available We present a general theory of estimation of analysis error covariances based on cross-validation as well as a geometric interpretation of the method. In particular, we use the variance of passive observation-minus-analysis residuals and show that the true analysis error variance can be estimated, without relying on the optimality assumption. This approach is used to obtain near optimal analyses that are then used to evaluate the air quality analysis error using several different methods at active and passive observation sites. We compare the estimates according to the method of Hollingsworth-Lönnberg, Desroziers et al., a new diagnostic we developed, and the perceived analysis error computed from the analysis scheme, to conclude that, as long as the analysis is near optimal, all estimates agree within a certain error margin.

  20. Neural network analysis of vibration signals in the diagnostics of ...

    African Journals Online (AJOL)

    The article is devoted to the improvement of heat network calculation and diagnostics methods. Currently used instruments have many shortcomings for the diagnosis of pipelines, including low reliability of defect detection and subjective decision-making. The authors created an experimental stand, which allows to conduct ...

  1. Comparative analysis of two rapid diagnostic tests for diagnosis of ...

    African Journals Online (AJOL)

    This study aims at comparing the diagnostic efficiencies of two commercially available kits for detecting Plasmodium falciparum infection in urine and blood of febrile patients for malaria diagnosis. This was an observational study in which matched blood and urine from symptomatic patients were tested for malaria using two ...

  2. Cost analysis of breast cancer diagnostic assessment programs.

    Science.gov (United States)

    Honein-AbouHaidar, G N; Hoch, J S; Dobrow, M J; Stuart-McEwan, T; McCready, D R; Gagliardi, A R

    2017-10-01

    Diagnostic assessment programs (daps) appear to improve the diagnosis of cancer, but evidence of their cost-effectiveness is lacking. Given that no earlier study used secondary financial data to estimate the cost of diagnostic tests in the province of Ontario, we explored how to use secondary financial data to retrieve the cost of key diagnostic test services in daps, and we tested the reliability of that cost-retrieving method with hospital-reported costs in preparation for future cost-effectiveness studies. We powered our sample at an alpha of 0.05, a power of 80%, and a margin of error of ±5%, and randomly selected a sample of eligible patients referred to a dap for suspected breast cancer during 1 January-31 December 2012. Confirmatory diagnostic tests received by each patient were identified in medical records. Canadian Classification of Health Intervention procedure codes were used to search the secondary financial data Web portal at the Ontario Case Costing Initiative for an estimate of the direct, indirect, and total costs of each test. The hospital-reported cost of each test received was obtained from the host-hospital's finance department. Descriptive statistics were used to calculate the cost of individual or group confirmatory diagnostic tests, and the Wilcoxon signed-rank test or the paired t-test was used to compare the Ontario Case Costing Initiative and hospital-reported costs. For the 191 identified patients with suspected breast cancer, the estimated total cost of $72,195.50 was not significantly different from the hospital-reported total cost of $72,035.52 ( p = 0.24). Costs differed significantly when multiple tests to confirm the diagnosis were completed during one patient visit and when confirmatory tests reported in hospital data and in medical records were discrepant. The additional estimated cost for non-salaried physicians delivering diagnostic services was $28,387.50. It was feasible to use secondary financial data to retrieve the cost

  3. Systematic review of reliability and diagnostic validity of joint vibration analysis for diagnosis of temporomandibular disorders.

    Science.gov (United States)

    Sharma, Sonia; Crow, Heidi C; McCall, W D; Gonzalez, Yoly M

    2013-01-01

    To conduct a systematic review of papers reporting the reliability and diagnostic validity of the joint vibration analysis (JVA) for diagnosis of temporomandibular disorders (TMD). A search of Pubmed identified English-language publications of the reliability and diagnostic validity of the JVA. Guidelines were adapted from applied STAndards for the Reporting of Diagnostic accuracy studies (STARD) to evaluate the publications. Fifteen publications were included in this review, each of which presented methodological limitations. This literature is unable to provide evidence to support the reliability and diagnostic validity of the JVA for diagnosis of TMD.

  4. Using Meta-Analysis to Inform the Design of Subsequent Studies of Diagnostic Test Accuracy

    Science.gov (United States)

    Hinchliffe, Sally R.; Crowther, Michael J.; Phillips, Robert S.; Sutton, Alex J.

    2013-01-01

    An individual diagnostic accuracy study rarely provides enough information to make conclusive recommendations about the accuracy of a diagnostic test; particularly when the study is small. Meta-analysis methods provide a way of combining information from multiple studies, reducing uncertainty in the result and hopefully providing substantial…

  5. Common pitfalls in statistical analysis: Understanding the properties of diagnostic tests - Part 1.

    Science.gov (United States)

    Ranganathan, Priya; Aggarwal, Rakesh

    2018-01-01

    In this article in our series on common pitfalls in statistical analysis, we look at some of the attributes of diagnostic tests (i.e., tests which are used to determine whether an individual does or does not have disease). The next article in this series will focus on further issues related to diagnostic tests.

  6. Electromagnetic analysis of ITER diagnostic equatorial port plugs during plasma disruptions

    International Nuclear Information System (INIS)

    Zhai, Y.; Feder, R.; Brooks, A.; Ulrickson, M.; Pitcher, C.S.; Loesser, G.D.

    2013-01-01

    Highlights: ► Disruption loads on ITER diagnostic equatorial port plugs are extracted. ► Upward major disruption produces the largest radial moment and radial force on diagnostic first walls and diagnostic shield modules. ► Large eddy currents on supporting rails, keys and water pipes are observed during disruption. -- Abstract: ITER diagnostic port plugs perform many functions including structural support of diagnostic systems under high electromagnetic loads while allowing for diagnostic access to the plasma. The design of diagnostic equatorial port plugs (EPP) are largely driven by electromagnetic loads and associate responses of EPP structure during plasma disruptions and VDEs. This paper summarizes results of transient electromagnetic analysis using Opera 3d in support of the design activities for ITER diagnostic EPP. A complete distribution of disruption loads on the diagnostic first walls (DFWs), diagnostic shield modules (DSMs) and the EPP structure, as well as impact on the system design integration due to electrical contact among various EPP structural components are discussed

  7. Environmental analysis for pipeline gas demonstration plants

    Energy Technology Data Exchange (ETDEWEB)

    Stinton, L.H.

    1978-09-01

    The Department of Energy (DOE) has implemented programs for encouraging the development and commercialization of coal-related technologies, which include coal gasification demonstration-scale activities. In support of commercialization activities the Environmental Analysis for Pipeline Gas Demonstration Plants has been prepared as a reference document to be used in evaluating potential environmental and socioeconomic effects from construction and operation of site- and process-specific projects. Effluents and associated impacts are identified for six coal gasification processes at three contrasting settings. In general, impacts from construction of a high-Btu gas demonstration plant are similar to those caused by the construction of any chemical plant of similar size. The operation of a high-Btu gas demonstration plant, however, has several unique aspects that differentiate it from other chemical plants. Offsite development (surface mining) and disposal of large quantities of waste solids constitute important sources of potential impact. In addition, air emissions require monitoring for trace metals, polycyclic aromatic hydrocarbons, phenols, and other emissions. Potential biological impacts from long-term exposure to these emissions are unknown, and additional research and data analysis may be necessary to determine such effects. Possible effects of pollutants on vegetation and human populations are discussed. The occurrence of chemical contaminants in liquid effluents and the bioaccumulation of these contaminants in aquatic organisms may lead to adverse ecological impact. Socioeconomic impacts are similar to those from a chemical plant of equivalent size and are summarized and contrasted for the three surrogate sites.

  8. Molecular diagnostics of periodontitis

    OpenAIRE

    Izabela Korona-Głowniak; Radosław Siwiec; Marcin Berger; Anna Malm; Jolanta Szymańska

    2017-01-01

    The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host’s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridi...

  9. Sensitivity analysis for publication bias in meta-analysis of diagnostic studies for a continuous biomarker.

    Science.gov (United States)

    Hattori, Satoshi; Zhou, Xiao-Hua

    2018-02-10

    Publication bias is one of the most important issues in meta-analysis. For standard meta-analyses to examine intervention effects, the funnel plot and the trim-and-fill method are simple and widely used techniques for assessing and adjusting for the influence of publication bias, respectively. However, their use may be subjective and can then produce misleading insights. To make a more objective inference for publication bias, various sensitivity analysis methods have been proposed, including the Copas selection model. For meta-analysis of diagnostic studies evaluating a continuous biomarker, the summary receiver operating characteristic (sROC) curve is a very useful method in the presence of heterogeneous cutoff values. To our best knowledge, no methods are available for evaluation of influence of publication bias on estimation of the sROC curve. In this paper, we introduce a Copas-type selection model for meta-analysis of diagnostic studies and propose a sensitivity analysis method for publication bias. Our method enables us to assess the influence of publication bias on the estimation of the sROC curve and then judge whether the result of the meta-analysis is sufficiently confident or should be interpreted with much caution. We illustrate our proposed method with real data. Copyright © 2017 John Wiley & Sons, Ltd.

  10. Ignition analysis for burn control and diagnostic developments in ITER

    International Nuclear Information System (INIS)

    Mitarai, O.; Muraoka, K.

    1997-01-01

    The temporal evolutions of the operating point during the ignition access and ignited operation phases are analysed on the basis of zero dimensional (0-D) equations in order to clarify the requirements for safe control of ignited operation and for the development of diagnostic systems in ITER. A stable and safe method of reaching the ignited operating point is identified as the 'higher temperature access' method, being compatible with the H mode power threshold constraints. It is found that the ignition boundary can be experimentally determined by a 'thermonuclear oscillation' of the operating point without knowing the power balance equation. On the other hand, the ignition boundary determined by the power balance equation has a larger error bar depending on the accuracy of the diagnostic system. The plasma waveform response to sudden changes in the various plasma parameters during ignited operation is also calculated, and fusion power regulation is demonstrated by feedback control of the fuelling and auxiliary heating power. (author)

  11. Instrumental neutron activation analysis in environmental research

    International Nuclear Information System (INIS)

    Bruin, M. de.

    1985-01-01

    The main characteristics of instrumental neutron activation analysis (INAA),relevant for environmental research and monitoring, was reviewed and discussed-sensitivity, suitable for detection of many toxic elements, the low risks of contamination of element loss, lack of matrix effects, lack of light element interference except for 24 Na, capability for multi-element determination, comparatively low costs. A detailed description of the IRI analysis system for routine INAA is given. The system is based on the single comparator method of standartization to take full advantage of multi-element without preparation and use the trace element standards. Zinc was used as mono element standard, the element concentrations are calculated on the basis of 65 Zn and 69m Zn-activities. The irradiations were carried out in a thermal neutron flux of 1.10 13 n/cm 2 .s. The gamma spectra is converted into element concentrations using a set of dedicated software, performing the following functions: spectrum analysis and interpretation, comparison and combination of the intermediate results from different decay times, generation of the final report, bookkeeping of the results obtained. The main applications of the INAA system mentioned are: identification of sources of heavy metal air pollution using air filters or biological indicators such as mosses, lichens, toe-nails, bird feathers, molusks and waterplants; and study of the uptake and translocation of heavy element in plants. Special attention was paid to mathematical techniques for a reliable interpretation of the element concentration patterns observed in sets of lichen samples. Future developments in INAA in environmental science are briefly mentioned

  12. Reporter gene bioassays in environmental analysis.

    Science.gov (United States)

    Köhler, S; Belkin, S; Schmid, R D

    2000-01-01

    In parallel to the continuous development of increasingly more sophisticated physical and chemical analytical technologies for the detection of environmental pollutants, there is a progressively more urgent need also for bioassays which report not only on the presence of a chemical but also on its bioavailability and its biological effects. As a partial fulfillment of that need, there has been a rapid development of biosensors based on genetically engineered bacteria. Such microorganisms typically combine a promoter-operator, which acts as the sensing element, with reporter gene(s) coding for easily detectable proteins. These sensors have the ability to detect global parameters such as stress conditions, toxicity or DNA-damaging agents as well as specific organic and inorganic compounds. The systems described in this review, designed to detect different groups of target chemicals, vary greatly in their detection limits, specificity, response times and more. These variations reflect on their potential applicability which, for most of the constructs described, is presently rather limited. Nevertheless, present trends promise that additional improvements will make microbial biosensors an important tool for future environmental analysis.

  13. 10 CFR 503.13 - Environmental impact analysis.

    Science.gov (United States)

    2010-01-01

    ... 10 Energy 4 2010-01-01 2010-01-01 false Environmental impact analysis. 503.13 Section 503.13... Exemptions § 503.13 Environmental impact analysis. In order to enable OFE to comply with NEPA, a petitioner..., and land resources; (3) Direct and indirect environmental impacts of the proposed action including...

  14. Integrating health and environmental impact analysis.

    Science.gov (United States)

    Reis, S; Morris, G; Fleming, L E; Beck, S; Taylor, T; White, M; Depledge, M H; Steinle, S; Sabel, C E; Cowie, H; Hurley, F; Dick, J McP; Smith, R I; Austen, M

    2015-10-01

    Scientific investigations have progressively refined our understanding of the influence of the environment on human health, and the many adverse impacts that human activities exert on the environment, from the local to the planetary level. Nonetheless, throughout the modern public health era, health has been pursued as though our lives and lifestyles are disconnected from ecosystems and their component organisms. The inadequacy of the societal and public health response to obesity, health inequities, and especially global environmental and climate change now calls for an ecological approach which addresses human activity in all its social, economic and cultural complexity. The new approach must be integral to, and interactive, with the natural environment. We see the continuing failure to truly integrate human health and environmental impact analysis as deeply damaging, and we propose a new conceptual model, the ecosystems-enriched Drivers, Pressures, State, Exposure, Effects, Actions or 'eDPSEEA' model, to address this shortcoming. The model recognizes convergence between the concept of ecosystems services which provides a human health and well-being slant to the value of ecosystems while equally emphasizing the health of the environment, and the growing calls for 'ecological public health' as a response to global environmental concerns now suffusing the discourse in public health. More revolution than evolution, ecological public health will demand new perspectives regarding the interconnections among society, the economy, the environment and our health and well-being. Success must be built on collaborations between the disparate scientific communities of the environmental sciences and public health as well as interactions with social scientists, economists and the legal profession. It will require outreach to political and other stakeholders including a currently largely disengaged general public. The need for an effective and robust science-policy interface has

  15. Coherent Energy and Environmental System Analysis

    DEFF Research Database (Denmark)

    Hvelplund, Frede; Mathiesen, Brian Vad; Østergaard, Poul Alberg

    energy and environmental analysis tools as well as analyses of the design and implementation of future renewable energy systems. For practical reasons, the work has been carried out as an interaction between five work packages, and a number of reports, papers and tools have been reported separately from...... each part of the project. A list of the separate work package reports is given at the end of this foreword while a complete list of all papers and reports can be found at the end of the report as well as at the following website: www.ceesa.dk. This report provides a summary of the results...... as indirectly via the work of the different work packages. By nature this means that each individual author cannot be responsible for every detail of the different reports and papers of work packages conducted by others. Such responsibility relies on the specific authors of the sub-reports and papers. Moreover...

  16. SIMS depth profile analysis of environmental microparticles

    International Nuclear Information System (INIS)

    Konarski, P.

    2000-01-01

    Environmental and technological research demands chemical characterization of aerosol particles so minute in size, that conventional methods for bulk analyses are simply not applicable. In this work novel application of secondary ion mass spectrometry (SIMS) for characterization of microparticles suspended in atmosphere of the working environment of glass plant Thomson Polkolor, Piaseczno and steelworks Huta Sendzimira, Cracow is presented. The new technique based on sample rotation in depth profile analysis of sub-micrometer particulate material was performed on SAJW-02 analyser equipped with Balzers 16 mm quadrupole spectrometer and sample rotation manipulator using 5 keV Ar + and O 2 + ion beams. The results were compared with the standard method used on ims-3f Cameca analyser 12 keV O 2 + ion beam. Grain size distributions of aerosol microparticles were estimated using eight-stage cascade impactor with particle size range of 0.2 μm to 15 μm. Elemental concentration and crystalline structure of the collected dust particles were performed using spark source mass spectrometry and X-ray diffraction methods. SIMS depth profile analysis shows that sub-micrometer particles do not have uniform morphology, The core-shell structure has been observed for particles collected in both factories. Presented models show that the steelworks particles consists mainly of iron and manganese cores. At the shells of these microparticles :lead, chlorine and fluorine are found. The cores of glass plant submicrometer particles consists mainly of lead-zirconium glass covered by a shell containing carbon and copper. Sample rotation technique applied SIMS appears to be an effective tool for environmental microparticle morphology studies. (author)

  17. Using the method of judgement analysis to address variations in diagnostic decision making

    OpenAIRE

    Hancock, Helen C; Mason, James M; Murphy, Jerry J

    2012-01-01

    Abstract Background Heart failure is not a clear-cut diagnosis but a complex clinical syndrome with consequent diagnostic uncertainty. Judgment analysis is a method to help clinical teams to understand how they make complex decisions. The method of judgment analysis was used to determine the factors that influence clinicians' diagnostic decisions about heart failure. Methods Three consultants, three middle grade doctors, and two junior doctors each evaluated 45 patient scenarios. The main out...

  18. Multi-shot analysis of the gamma reaction history diagnostic

    International Nuclear Information System (INIS)

    Sayre, D. B.; Bernstein, L. A.; Church, J. A.; Stoeffl, W.; Herrmann, H. W.

    2012-01-01

    The gamma reaction history diagnostic at the National Ignition Facility has the capability to determine a number of important performance metrics for cryogenic deuterium-tritium implosions: the fusion burn width, bang time and yield, as well as the areal density of the compressed ablator. Extracting those values from the measured γ rays of an implosion, requires accounting for a γ-ray background in addition to the impulse response function of the instrument. To address these complications, we have constructed a model of the γ-ray signal, and are developing a simultaneous multi-shot fitting routine to constrain its parameter space.

  19. Some methods of analysis and diagnostics of corroded components from nuclear power plant

    International Nuclear Information System (INIS)

    Mogosan, S.; Radulescu, M.; Fulger, M.; Stefanescu, D.

    2010-01-01

    In Nuclear Power Plants (NPP) it is necessary to ensure a longer and safe operation as difficult and expensive it is the maintenance of these very complex installations and equipment. In this regard, The Analysis and Diagnostic Laboratory Corroded Metal Components in Nuclear Facilities-LADICON; was authorized RENAR and CNCAN (National Commission for Nuclear Activities Control) notified as a testing laboratory for nuclear-grade materials. As part of the investigation and evaluation of corrosion behavior for these materials two types of test methods are used i.e. longer corrosion tests such as: autoclaving at high temperature and pressure in different chemical media-specific patterns in NPP and accelerated methods like: electrochemical techniques, accelerated chemical tests, etc. This paper presents some methods of analysis for materials corrosion; methods of assessment of corrosion of structural materials exposed to specific operating conditions and environment in NPPs. The electrochemical measurements show the following advantages: a) Allowing a direct method to accelerate the corrosion processes without altering the environment, b) It can be used as an nondestructive tool for assessing the rate of corrosion and c) Offers the possibility of conducting such investigations in - situ and ex- situ. Corroborating the environmental chemistry that was born on samples movies investigation results obtained by the methods above, it is possible to identify the types of corrosion of the materials and sometimes even those processes and mechanisms of corrosion. (authors)

  20. Age and Environmental Concern: A Multivariate Analysis.

    Science.gov (United States)

    Buttel, Frederick H.

    1979-01-01

    This paper provides detailed evidence on the relationships among age, education, and environmental values. The relative strengths of association of age and education in predicting environmental attitudes are evaluated. Present and future generational politics of environmentalism are discussed. (Author/EB)

  1. Building Performance Optimization While Empowering Occupants towards Environmentally Sustainable Behavior through Continuous Monitoring and Diagnostics

    Science.gov (United States)

    2016-12-01

    transportation, and energy-related activities in an environmentally, economically, and fiscally sound manner. “To improve environmental performance...size, walls and windows insulation value). o Dynamic Variables: occupancy patterns, lighting system (technology and efficiency of the fixtures), and...during heating season. The survey asked questions about thermal, visual, acoustic , and air quality satisfaction levels; but only thermal and air quality

  2. Diagnostic value of multislice computed tomography angiography in coronary artery disease: A meta-analysis

    International Nuclear Information System (INIS)

    Sun Zhonghua; Jiang Wen

    2006-01-01

    Purpose: To perform a meta-analysis of the diagnostic value of multislice CT (MSCT) angiography in the detection of coronary artery disease (CAD) when compared to conventional coronary angiography. Materials and methods: A search of PubMed and MEDLINE databases for English literature was performed. Only studies with at least 10 patients comparing MSCT angiography with conventional coronary angiography in the detection of CAD were included. Diagnostic value of MSCT angiography compared to coronary angiography was compared and analyzed at segment-, vessel- and patient-based assessment. Results: 47 studies (67 comparisons) met the criteria and were included in our study. Pooled overall sensitivity, specificity and 95% confidence interval for MSCT angiography in the detection of CAD were 83% (79%, 89%), 93% (91%, 96%) at segment-based analysis; 90% (87%, 94%), 87% (80%, 93%) at vessel-based analysis; and 91% (88%, 95%), 86% (81%, 92%) at patient-based analysis, respectively. Diagnostic accuracy of MSCT angiography in evaluating assessable segments was significantly improved with 64-slice scanners when compared to that with 4- and 16-slice scanners (p < 0.05). Conclusion: Our meta-analysis showed that MSCT angiography has potential diagnostic accuracy in the detection of CAD. Diagnostic performance of MSCT angiography has been significantly improved with the latest 64-slice CT, with resultant high qualitative and quantitative diagnostic accuracy. 16-slice CT was limited in spatial resolution which makes it difficult to perform quantitative assessment of coronary artery stenoses

  3. Nuclear spectrometry for environmental analysis and mapping

    International Nuclear Information System (INIS)

    Simon, Aliz

    2013-01-01

    visits, and provision of equipment. This talk gives an overview of the lAEA Physics Section activities with a special emphasis on the following activities: 1)Improving the analytical performance of PIXE and other IBA techniques; 2)Networking for environmental analysis; 3)Radioisotope environmental mapping; 4)Future perspectives for new IBA methods, especially Heavy lon PIXE combined with MeVSIMS. (author)

  4. Nuclear spectrometry for environmental analysis and mapping

    Energy Technology Data Exchange (ETDEWEB)

    Simon, Aliz, E-mail: Aliz.Simon@iaea.org [International Atomic Energy Agency (IAEA), Division of Physical and Chemical Sciences, Vienna (Austria)

    2013-07-01

    visits, and provision of equipment. This talk gives an overview of the lAEA Physics Section activities with a special emphasis on the following activities: 1)Improving the analytical performance of PIXE and other IBA techniques; 2)Networking for environmental analysis; 3)Radioisotope environmental mapping; 4)Future perspectives for new IBA methods, especially Heavy lon PIXE combined with MeVSIMS. (author)

  5. Nepal - Country Environmental Analysis : Strengthening Institutions and Management Systems for Enhanced Environmental Governance

    OpenAIRE

    World Bank

    2007-01-01

    The main objective of the Country Environmental Analysis (CEA) in Nepal is to identify opportunities for enhancing the overall performance of select environmental management systems through improvements in the effectiveness of institutions, policies, and processes. CEA has been built upon the following three primary study components: (a) an examination of the environmental issues associate...

  6. Building Performance Optimization while Empowering Occupants Toward Environmentally Sustainable Behavior through Continuous Monitoring and Diagnostics

    Science.gov (United States)

    2016-12-01

    Federal Energy Management Program FM Facility Manager GHG Green House Gases HASP Health and Safety Plan HVAC Heating Ventilation and... workplace energy efficiency enhancement by the DOD personnel. 2.1.2 ID-F Intelligent Dashboards for Facility Managers Creation of the Base Building...demonstration project. The first technology, ‘ID-F,’ targets building facility managers and allows real time diagnostics for BAS systems with features

  7. Bioclim Deliverable D1: environmental change analysis

    International Nuclear Information System (INIS)

    2001-01-01

    The BIOCLIM project on modelling sequential Biosphere systems under Climate change for radioactive waste disposal is part of the EURATOM fifth European framework programme. The project was launched in October 2000 for a three-year period. The project aims at providing a scientific basis and practical methodology for assessing the possible long term impacts on the safety of radioactive waste repositories in deep formations due to climate and environmental change. The project brings together a number of representatives from both European radioactive waste management organisations which have national responsibilities for the safe disposal of radioactive waste, either as disposers or regulators, and several highly experienced climate research teams. In particular, BIOCLIM aims to address the important objective of how to represent the development of future biosphere systems by addressing both how to model long-term climate change, the relevant environmental consequences of such changes and the implementation of a sequential approach to such changes. The results from the development of this sophisticated approach will be of great benefit for improving long term radiological impact calculations and the information presented in a safety case. Simulations will be conducted to represent the time series of long-term climate in three European areas within which disposal sites may be established (i.e. Central/Southern Spain, Northeast of France and Central Britain). Two complementary strategies will provide representations of future climate predictions together with associated vegetation patterns using either an analysis of distinct climate states or a continuous climate simulation over at least one glacial-interglacial cycle and possibly for other selected periods over the next 1,000,000 years. These results will be used to derive the characteristics of possible future human environments (i.e. biosphere systems) through which radionuclides, emerging from the repository, may

  8. Selected industrial and environmental applications of neutron activation analysis

    International Nuclear Information System (INIS)

    Kucera, J.

    1999-01-01

    A review of the applications of Instrumental Neutron Activation Analysis (INAA) in the industrial and environmental fields is given. Detection limits for different applications are also given. (author)

  9. An analysis of environmental data transmission

    Science.gov (United States)

    Yuan, Lina; Chen, Huajun; Gong, Jing

    2017-05-01

    To comprehensively construct environmental automatic monitoring has become the urgent need of environmental management, is a major measure to implement the scientific outlook on development and build a harmonious socialist society, and is an inevitable choice of “building a resource-conserving and environment-friendly society”, which is of great importance and profound significance to adjust the economic structure and transform growth pattern. This article first introduces the importance of environmental data transmission, then expounds the characteristics, key technologies, transmitting mode, and design ideas of environmental data transmission process, and finally, summarizes the full text.

  10. Computized analysis of diagnostic level in breast diseases and frequency of their clinicoroentgenological symptoms

    International Nuclear Information System (INIS)

    Babij, Ya.S.; Krakhmaleva, L.P.; Shumakov, A.G.

    1988-01-01

    A standardized chart with a list of clinicoroentgenological symptoms of the most frequent mammary gland diseases is developed. The data of computer analysis of the diagnostics level and the frequency of clinicoroentgenological symptoms of different diseases of the mammary gland are given. The data obtained can be used for conventional and computer diagnostics of mammary gland diseases, as well as as a basis for the further study of semiotics of different pathological processes in the mammary gland. 22 refs

  11. Simplified diagnostic coding sheet for computerized data storage and analysis in ophthalmology.

    Science.gov (United States)

    Tauber, J; Lahav, M

    1987-11-01

    A review of currently-available diagnostic coding systems revealed that most are either too abbreviated or too detailed. We have compiled a simplified diagnostic coding sheet based on the International Coding and Diagnosis (ICD-9), which is both complete and easy to use in a general practice. The information is transferred to a computer, which uses the relevant (ICD-9) diagnoses as database and can be retrieved later for display of patients' problems or analysis of clinical data.

  12. An Analysis of Environmental Advertising Frames from 1990 to 2010

    OpenAIRE

    VanDyke, Matthew Steven

    2012-01-01

    Recent calls in environmental communication literature suggest researchers should understand the relationships between media message content, message construction, and audience effects. This thesis analyzed environmental advertising frames over time to inform strategic environmental communication research and practice. The study was a media content analysis guided by framing theory. Framing theory asserts the construction of media messages involves the selection and salience of particular mes...

  13. Magnetic resonance colonography versus colonoscopy as a diagnostic investigation for colorectal cancer: a meta-analysis

    International Nuclear Information System (INIS)

    Purkayastha, S.; Tekkis, P.P.; Athanasiou, T.; Aziz, O.; Negus, R.; Gedroyc, W.; Darzi, A.W.

    2005-01-01

    AIMS: Magnetic resonance colonography (MRC) is emerging as a potential complementary investigation for the diagnosis of colorectal cancer (CRC) and also for benign pathology such as diverticular disease. A meta-analysis reporting the use of MRC is yet to be performed. The aim of this study was to evaluate the diagnostic accuracy of MRC compared with the gold-standard investigation, conventional colonoscopy (CC). METHODS: A literature search was carried out to identify studies containing comparative data between MRC findings and CC findings. Quantitative meta-analysis for diagnostic tests was performed, which included the calculation of independent sensitivities, specificities, diagnostic odds ratios, the construction of summary receiver operating characteristic (SROC) curves, pooled analysis and sensitivity analysis. The study heterogeneity was evaluated by the Q-test using a random-effect model to accommodate the cluster of outcomes between individual studies. RESULTS: In all, 8 comparative studies were identified, involving 563 patients. The calculated pooled sensitivity for all lesions was 75% (95% CI: 47% to 91%), the specificity was 96% (95% CI: 86% to 98%) and the area under the ROC curve was 90% (weighted). On sensitivity analysis, MRC had a better diagnostic accuracy for CRC than for polyps, with a sensitivity of 91% (95% CI: 97% to 91%), a specificity of 98% (95% CI: 66% to 99%) and an area under the ROC curve of 92%. There was no significant heterogeneity between the studies with regard to the diagnostic accuracy of MRC for CRC. CONCLUSION: This meta-analysis suggests that MRC is an imaging technique with high discrimination for cases presenting with colorectal cancer. The exact diagnostic role of MRC needs to be clarified (e.g. suitable for an elderly person with suspected CRC). Further evaluation is necessary to refine its applicability and diagnostic accuracy in comparison with other imaging methods such as computed tomography colonography

  14. Cost benefit analysis in diagnostic radiology: glossary and definitions

    International Nuclear Information System (INIS)

    Golder, W.

    1999-01-01

    Cost efficiency analyses in clinical radiology require the application of methods and techniques that are not yet part of the academic qualifications of the specialists. The procedures used are borrowed from economics, decision theory, applied social sciences, epidemiology and statistics. Many expressions hail from the angloamerican literature and are presently not yet germanized unequivocally. This survey is intended to present main terms of cost efficiency analysis in the English version as well as a German translation, to give a clear definition and, if necessary, explanatory notes, and to illustrate their application by means of concrete radiologic examples. The selection of the terms is based on the hierarchical models of health technology assessment resp. clinical outcome research by Fryback and Thronbury resp. Maisey and Hutton. In concrete terms, both the differences between benefit, outcomes, and utility and the differences between effectiveness, efficacy and efficiency and the differences between direct, indirect, intangible, and marginal costs are explained. True cost efficiency analysis is compared with cost effectiveness analysis, cost identification analysis, cost minimization analysis, and cost utility analysis. Applied social sciences are represented by the Medical Outcomes Study Short Form-36 and the QALY conception. From decision theory both the analysis of hypothetical alternatives and the Markov model are taken. Finally, sensitivity analysis and the procedures of combined statistical evaluation of comparable results (meta-analysis) are quoted. (orig.) [de

  15. Method for environmental risk analysis (MIRA) revision 2007

    International Nuclear Information System (INIS)

    2007-04-01

    OLF's instruction manual for carrying out environmental risk analyses provides a united approach and a common framework for environmental risk assessments. This is based on the best information available. The manual implies standardizations of a series of parameters, input data and partial analyses that are included in the environmental risk analysis. Environmental risk analyses carried out according to the MIRA method will thus be comparable between fields and between companies. In this revision an update of the text in accordance with today's practice for environmental risk analyses and prevailing regulations is emphasized. Moreover, method adjustments for especially protected beach habitats have been introduced, as well as a general method for estimating environmental risk concerning fish. Emphasis has also been put on improving environmental risk analysis' possibilities to contribute to a better management of environmental risk in the companies (ml)

  16. Systematic Analysis of Painful Total Knee Prosthesis, a Diagnostic Algorithm

    Directory of Open Access Journals (Sweden)

    Oliver Djahani

    2013-12-01

    Full Text Available   Remaining pain after total knee arthroplasty (TKA is a common observation in about 20% of postoperative patients; where in about 60% of these knees require early revision surgery within five years. Obvious causes of this pain could be identified simply with clinical examinations and standard radiographs. However, unexplained painful TKA still remains a challenge for the surgeon. The management should include a multidisciplinary approach to the patient`s pain as well as addressing the underlying etiology. There are a number of extrinsic (tendinopathy, hip, ankle, spine, CRPS and so on and intrinsic (infection, instability, malalignment, wear and so on causes of painful knee replacement. On average, diagnosis takes more than 12 months and patients become very dissatisfied and some of them even acquire psychological problems. Hence, a systematic diagnostic algorithm might be helpful. This review article aims to act as a guide to the evaluation of patients with painful TKA described in 10 different steps. Furthermore, the preliminary results of a series of 100 consecutive cases will be discussed. Revision surgery was performed only in those cases with clear failure mechanism.

  17. ROC Analysis of Diagnostic Performance in Liver Scan

    International Nuclear Information System (INIS)

    Lee, Myung Chul; Moon, Dyuk Hyuk; Koh, Chang Soon; Matumoto, Toru; Tateno, Yukio

    1988-01-01

    To evaluate diagnostic accuracy of liver scintigraphy we analysed liver scans of 143 normal and 258 patients with various liver diseases. Three ROC curves for SOL, liver cirrhosis and diffuse liver disease were fitted using rating methods and areas under the ROC curves and their standard errors were calculated by the trapezoidal rule and the variance of the Wilcoxon statistic suggested by McNeil. We compared these results with that of National Institute of Radiological Science in Japan. 1) The sensitivity of liver scintigraphy was 74.2% in SOL, 71.8% in liver cirrhosis and 34.8% in diffuse liver disease. The specificity was 96.0% in SOL, 94.2% in liver cirrhosis and 87.6% in diffuse liver disease. 2) ROC curves of SOL and liver cirrhosis approached the upper left-hand corner closer than that of diffuse liver disease. Area (± standard error) under the ROC curve was 0.868±0.024 in SOL and 0.867±0.028 in liver cirrhosis. These were significantly higher than 0.658±0.043 in diffuse liver disease. 3) There was no interobserver difference in terms of ROC curves. But low sensitivity and high specificity of authors' SOL diagnosis suggested we used more strict decision threshold.

  18. Diagnostic value of perinatal autopsies: analysis of 486 cases.

    Science.gov (United States)

    Neşe, Nalan; Bülbül, Yeşim

    2018-02-23

    Autopsy is a beneficial procedure to determine the cause of death and the frequency of anomalies in perinatal losses. Even in the event of an autopsy not providing any additional information, completion of the procedure confirming the clinical diagnoses gives reassurance to both clinicians and parents. Here we present a 15-year archival study based on findings of perinatal autopsies. Four hundred and eighty-six cases from our archive were reviewed and according to the findings they were divided into three subcategories; (1) miscarriages (MCF); (2) fetuses terminated (FTA) for vital anomalies detected by prenatal ultrasonography; (3) premature or term newborns died within first month of life (neonates: NN). Autopsies were documented and classified according to week/age of cases, anomalies and causes of abortion or death. Two hundred and twenty-six of 486 cases (46.5%) were in MCF group while 227 (46.7%) and 33 (6.8%) were of them in FTA and NN groups, respectively. In FTA group, the most frequent anomaly detected was neural tube defects. In NN group, prematurity related complications were the most common cause of death. The autopsy process was found valuable in 39.7% of all cases. We suggest that autopsy procedure is diagnostically valuable even in situations when there is USG findings that are confirming FTAs or there is no important major fetal or placental anomaly detected in MCFs.

  19. A Lexical Analysis of Environmental Sound Categories

    Science.gov (United States)

    Houix, Olivier; Lemaitre, Guillaume; Misdariis, Nicolas; Susini, Patrick; Urdapilleta, Isabel

    2012-01-01

    In this article we report on listener categorization of meaningful environmental sounds. A starting point for this study was the phenomenological taxonomy proposed by Gaver (1993b). In the first experimental study, 15 participants classified 60 environmental sounds and indicated the properties shared by the sounds in each class. In a second…

  20. [Analysis of characteristics and influence factors of diagnostic delay of endometriosis].

    Science.gov (United States)

    Han, X T; Guo, H Y; Kong, D L; Han, J S; Zhang, L F

    2018-02-25

    Objective: To access the influence factors of diagnostic delay of endometriosis. Methods: We designed a questionnaire of diagnostic delay of endometriosis. From February 2014 to February 2016, 400 patients who had dysmenorrhea and diagnosed with endometriosis by surgery in Peking University Third Hospital were surveyed retrospectively. Time and risk factors of diagnostic delay were analyzed. Results: The diagnostic delay of 400 patients was 13.0 years (0.2-43.0 years), 78.5%(314/400) patients thought pain was a normal phenomenon and didn't see the doctor. Patients who suffered dysmenorrhea at menarche experienced longer diagnostic delay than those who had dysmenorrhea after menarche (18.0 vs 4.5 years; Z= 191.800, Pendometriosis (DIE) , family history of dysmenorrhea or endometriosis, previous surgical history of endometriosis, high stage, with infertility, adenomyoma or other symptoms, could help to shorten diagnostic delay with no significant difference ( P> 0.05) . By multiple logistic regression analysis, the results shown that whether have dysmenorrhea at menarche and clinical diagnosis time were the independent factors affecting delayed diagnosis ( Pendometriosis is common and the mean delay time is 13.0 years mainly due to the unawareness of dysmenorrhea. Dysmenorrhea at menarche, clinical diagnosis time and dysmenorrhea intensity are the factors affecting time of diagnostic delay.

  1. Comparative Laser Spectroscopy Diagnostics for Ancient Metallic Artefacts Exposed to Environmental Pollution

    Directory of Open Access Journals (Sweden)

    Łukasz Ciupiński

    2010-05-01

    Full Text Available Metal artworks are subjected to corrosion and oxidation processes due to reactive agents present in the air, water and in the ground that these objects have been in contact with for hundreds of years. This is the case for archaeological metals that are recovered from excavation sites, as well as artefacts exposed to polluted air. Stabilization of the conservation state of these objects needs precise diagnostics of the accrued surface layers and identification of original, historical materials before further protective treatments, including safe laser cleaning of unwanted layers. This paper presents analyses of the chemical composition and stratigraphy of corrosion products with the use of laser induced breakdown spectroscopy (LIBS and Raman spectroscopy. The discussion of the results is supported by material studies (SEM-EDS, XRF, ion-analyses. The tests were performed on several samples taken from original objects, including copper roofing from Wilanów Palace in Warsaw and Karol Poznański Palace in Łódź, bronze decorative figures from the Wilanów Palace gardens, and four archaeological examples of old jewellery (different copper alloys. Work has been performed as a part of the MATLAS project in the frames of EEA and Norway Grants (www.matlas.eu and the results enable the comparison of the methodology and to elaborate the joint diagnostic procedures of the three project partner independent laboratories.

  2. Comparative Laser Spectroscopy Diagnostics for Ancient Metallic Artefacts Exposed to Environmental Pollution

    Science.gov (United States)

    Ciupiński, Łukasz; Fortuna-Zaleśna, Elżbieta; Garbacz, Halina; Koss, Andrzej; Kurzydłowski, Krzysztof J.; Marczak, Jan; Mróz, Janusz; Onyszczuk, Tomasz; Rycyk, Antoni; Sarzyński, Antoni; Skrzeczanowski, Wojciech; Strzelec, Marek; Zatorska, Anna; Żukowska, Grażyna Z.

    2010-01-01

    Metal artworks are subjected to corrosion and oxidation processes due to reactive agents present in the air, water and in the ground that these objects have been in contact with for hundreds of years. This is the case for archaeological metals that are recovered from excavation sites, as well as artefacts exposed to polluted air. Stabilization of the conservation state of these objects needs precise diagnostics of the accrued surface layers and identification of original, historical materials before further protective treatments, including safe laser cleaning of unwanted layers. This paper presents analyses of the chemical composition and stratigraphy of corrosion products with the use of laser induced breakdown spectroscopy (LIBS) and Raman spectroscopy. The discussion of the results is supported by material studies (SEM-EDS, XRF, ion-analyses). The tests were performed on several samples taken from original objects, including copper roofing from Wilanów Palace in Warsaw and Karol Poznański Palace in ŁódŸ, bronze decorative figures from the Wilanów Palace gardens, and four archaeological examples of old jewellery (different copper alloys). Work has been performed as a part of the MATLAS project in the frames of EEA and Norway Grants (www.matlas.eu) and the results enable the comparison of the methodology and to elaborate the joint diagnostic procedures of the three project partner independent laboratories. PMID:22399915

  3. Diagnostic reframing of intractable environmental problems: Case of a contested multiparty public land-use conflict

    Science.gov (United States)

    Stanley T. Asah; David N. Bengston; Keith Wendt; Kristen C. Nelson

    2012-01-01

    Intractable conflicts are omnipresent in environmental management. These conflicts do not necessarily resist resolution but need to be fundamentally transformed in order to reach agreement. Reframing, a process that allows disputants to create new alternative understandings of the problem, is one way of transforming these conflicts. Cognitive and interactional...

  4. Receiver operating characteristic analysis of eyewitness memory: comparing the diagnostic accuracy of simultaneous versus sequential lineups.

    Science.gov (United States)

    Mickes, Laura; Flowe, Heather D; Wixted, John T

    2012-12-01

    A police lineup presents a real-world signal-detection problem because there are two possible states of the world (the suspect is either innocent or guilty), some degree of information about the true state of the world is available (the eyewitness has some degree of memory for the perpetrator), and a decision is made (identifying the suspect or not). A similar state of affairs applies to diagnostic tests in medicine because, in a patient, the disease is either present or absent, a diagnostic test yields some degree of information about the true state of affairs, and a decision is made about the presence or absence of the disease. In medicine, receiver operating characteristic (ROC) analysis is the standard method for assessing diagnostic accuracy. By contrast, in the eyewitness memory literature, this powerful technique has never been used. Instead, researchers have attempted to assess the diagnostic performance of different lineup procedures using methods that cannot identify the better procedure (e.g., by computing a diagnosticity ratio). Here, we describe the basics of ROC analysis, explaining why it is needed and showing how to use it to measure the performance of different lineup procedures. To illustrate the unique advantages of this technique, we also report 3 ROC experiments that were designed to investigate the diagnostic accuracy of simultaneous versus sequential lineups. According to our findings, the sequential procedure appears to be inferior to the simultaneous procedure in discriminating between the presence versus absence of a guilty suspect in a lineup.

  5. Quantitative evaluation of visual detection performance in medicine: ROC analysis and determination of diagnostic benefit

    International Nuclear Information System (INIS)

    Metz, C.E.; Starr, S.J.; Lusted, L.B.

    1976-01-01

    An ROC curve provides an empirical description of the trade-offs which are possible among the various types of correct and incorrect decisions as the human decision-maker varies one or more confidence thresholds. Conventional ROC curves measured in simple decision-making situations can, in some cases, be used to predict human decision performance in more complex situations. By considering both the consequences of the various types of diagnostic decisions and the overhead cost of a diagnostic study, one can use the ROC curve to evaluate the diagnostic usefulness of a study in any particular clinical context. Since the ROC curve describes the possible relationships among the probabilities of the various types of correct and incorrect decisions, it plays a central role in optimizing diagnostic strategies using the general techniques of decision analysis. Applications in radiographic image evaluation are described

  6. Applied research of environmental monitoring using instrumental neutron activation analysis

    Energy Technology Data Exchange (ETDEWEB)

    Chung, Young Sam; Moon, Jong Hwa; Chung, Young Ju

    1997-08-01

    This technical report is written as a guide book for applied research of environmental monitoring using Instrumental Neutron Activation Analysis. The contents are as followings; sampling and sample preparation as a airborne particulate matter, analytical methodologies, data evaluation and interpretation, basic statistical methods of data analysis applied in environmental pollution studies. (author). 23 refs., 7 tabs., 9 figs.

  7. Analysis of Steel Wire Rope Diagnostic Data Applying Multi-Criteria Methods

    Directory of Open Access Journals (Sweden)

    Audrius Čereška

    2018-02-01

    Full Text Available Steel ropes are complex flexible structures used in many technical applications, such as elevators, cable cars, and funicular cabs. Due to the specific design and critical safety requirements, diagnostics of ropes remains an important issue. Broken wire number in the steel ropes is limited by safety standards when they are used in the human lifting and carrying installations. There are some practical issues on loose wires—firstly, it shows end of lifetime of the entire rope, independently of wear, lubrication or wrong winding on the drums or through pulleys; and, secondly, it can stick in the tight pulley—support gaps and cause deterioration of rope structure up to birdcage formations. Normal rope operation should not generate broken wires, so increasing of their number shows a need for rope installation maintenance. This paper presents a methodology of steel rope diagnostics and the results of analysis using multi-criteria analysis methods. The experimental part of the research was performed using an original test bench to detect broken wires on the rope surface by its vibrations. Diagnostics was performed in the range of frequencies from 60 to 560 Hz with a pitch of 50 Hz. The obtained amplitudes of the broken rope wire vibrations, different from the entire rope surface vibration parameters, was the significant outcome. Later analysis of the obtained experimental results revealed the most significant values of the diagnostic parameters. The evaluation of the power of the diagnostics was implemented by using multi-criteria decision-making (MCDM methods. Various decision-making methods are necessary due to unknown efficiencies with respect to the physical phenomena of the evaluated processes. The significance of the methods was evaluated using objective methods from the structure of the presented data. Some of these methods were proposed by authors of this paper. Implementation of MCDM in diagnostic data analysis and definition of the

  8. IR spectral analysis for the diagnostics of crust earthquake precursors

    Science.gov (United States)

    Umarkhodgaev, R. M.; Liperovsky, V. A.; Mikhailin, V. V.; Meister, C.-V.; Naumov, D. Ju

    2012-04-01

    In regions of future earthquakes, a few days before the seismic shock, the emanation of radon and hydrogen is being observed, which causes clouds of increased ionisation in the atmosphere. In the present work the possible diagnostics of these clouds using infrared (IR) spectroscopy is considered, which may be important and useful for the general geophysical system of earthquake prediction and the observation of industrial emissions of radioactive materials into the atmosphere. Some possible physical processes are analysed, which cause, under the condition of additional ionisation in a pre-breakdown electrical field, emissions in the IR interval. In doing so, the transparency region of the IR spectrum at wavelengths of 7-15 μm is taken into account. This transparency region corresponds to spectral lines of small atmospheric constituents like CH4, CO2, N2O, NO2, NO, and O3. The possible intensities of the IR emissions observable in laboratories and in nature are estimated. The acceleration process of the electrons in the pre-breakdown electrical field before its adhesion to the molecules is analysed. The laboratory equipment for the investigation of the IR absorption spectrum is constructed for the cases of normal and decreased atmospheric pressures. The syntheses of ozone and nitrous oxides are performed in the barrier discharge. It is studied if the products of the syntheses may be used to model atmospheric processes where these components take part. Spectra of products of the syntheses in the wavelength region of 2-10 μm are observed and analysed. A device is created for the syntheses and accumulation of nitrous oxides. Experiments to observe the IR-spectra of ozone and nitrous oxides during the syntheses and during the further evolution of these molecules are performed. For the earthquake prediction, practically, the investigation of emission spectra is most important, but during the laboratory experiments, the radiation of the excited molecules is shifted by a

  9. Analysis of Corporate Environmental Management: Methodological Aspects

    DEFF Research Database (Denmark)

    Madsen, Henning; Ulhøi, John Parm

    2001-01-01

    in business presents a challenge to management, however, since it implies a fundamental change in some of the ways of operating a company. This paper will briefly discuss how information on the actual extent of environmental management in Danish companies and the way it is applied has been collected based......Human activities cannot avoid influencing conditions in the natural environment one way or the other. This includes as well common activities in the business sector. But during the past few decades, environmental disasters in Seveso and Bhopal, and the Exxon Valdes oil spill in Alaska have...... contributed to an increasing awareness of the effect of business activities on the physical environment. To assist companies reduce, evaluate, monitor and control their environmental impact the concept of corporate environmental and resource management has been developed. Implementation of this concept...

  10. Selected environmental applications of neutron activation analysis

    International Nuclear Information System (INIS)

    Kucera, J.

    2001-01-01

    NAA is very useful for the determination of trace and minor elements in many environmental applications. While instrumental NAA (INAA) has a number of valid applications in this field, radiochemical NAA (RNAA) prior to, or post irradiation provides some significant advantages. One of the major focus points for environmental applications of NAA is to assess the magnitude of various pollutants. This paper discusses doing this via two methods, namely air monitoring and biological monitoring. (author)

  11. Analysis of diagnostic calorimeter data by the transfer function technique

    Energy Technology Data Exchange (ETDEWEB)

    Delogu, R. S., E-mail: rita.delogu@igi.cnr.it; Pimazzoni, A.; Serianni, G. [Consorzio RFX, Corso Stati Uniti, 35127 Padova (Italy); Poggi, C.; Rossi, G. [Università degli Studi di Padova, Via 8 Febbraio 1848, 35122 Padova (Italy)

    2016-02-15

    This paper describes the analysis procedure applied to the thermal measurements on the rear side of a carbon fibre composite calorimeter with the purpose of reconstructing the energy flux due to an ion beam colliding on the front side. The method is based on the transfer function technique and allows a fast analysis by means of the fast Fourier transform algorithm. Its efficacy has been tested both on simulated and measured temperature profiles: in all cases, the energy flux features are well reproduced and beamlets are well resolved. Limits and restrictions of the method are also discussed, providing strategies to handle issues related to signal noise and digital processing.

  12. Development of fault diagnostic technique using reactor noise analysis

    International Nuclear Information System (INIS)

    Park, Jin Ho; Kim, J. S.; Oh, I. S.; Ryu, J. S.; Joo, Y. S.; Choi, S.; Yoon, D. B.

    1999-04-01

    The ultimate goal of this project is to establish the analysis technique to diagnose the integrity of reactor internals using reactor noise. The reactor noise analyses techniques for the PWR and CANDU NPP(Nuclear Power Plants) were established by which the dynamic characteristics of reactor internals and SPND instrumentations could be identified, and the noise database corresponding to each plant(both Korean and foreign one) was constructed and compared. Also the change of dynamic characteristics of the Ulchin 1 and 2 reactor internals were simulated under presumed fault conditions. Additionally portable reactor noise analysis system was developed so that real time noise analysis could directly be able to be performed at plant site. The reactor noise analyses techniques developed and the database obtained from the fault simulation, can be used to establish a knowledge based expert system to diagnose the NPP's abnormal conditions. And the portable reactor noise analysis system may be utilized as a substitute for plant IVMS(Internal Vibration Monitoring System). (author)

  13. Development of fault diagnostic technique using reactor noise analysis

    Energy Technology Data Exchange (ETDEWEB)

    Park, Jin Ho; Kim, J. S.; Oh, I. S.; Ryu, J. S.; Joo, Y. S.; Choi, S.; Yoon, D. B

    1999-04-01

    The ultimate goal of this project is to establish the analysis technique to diagnose the integrity of reactor internals using reactor noise. The reactor noise analyses techniques for the PWR and CANDU NPP(Nuclear Power Plants) were established by which the dynamic characteristics of reactor internals and SPND instrumentations could be identified, and the noise database corresponding to each plant(both Korean and foreign one) was constructed and compared. Also the change of dynamic characteristics of the Ulchin 1 and 2 reactor internals were simulated under presumed fault conditions. Additionally portable reactor noise analysis system was developed so that real time noise analysis could directly be able to be performed at plant site. The reactor noise analyses techniques developed and the database obtained from the fault simulation, can be used to establish a knowledge based expert system to diagnose the NPP's abnormal conditions. And the portable reactor noise analysis system may be utilized as a substitute for plant IVMS(Internal Vibration Monitoring System). (author)

  14. Diagnostic accuracy of dual-energy computed tomography in patients with gout: A meta-analysis.

    Science.gov (United States)

    Lee, Young Ho; Song, Gwan Gyu

    2017-08-01

    This study aimed to evaluate the diagnostic performance of dual-energy computed tomography (DECT) for patients with gout. We searched the Medline, Embase, and Cochrane Library databases, and performed a meta-analysis on the diagnostic accuracy of DECT in patients with gout. A total of eight studies including 510 patients with gout and 268 controls (patients with non-gout inflammatory arthritis) were available for the meta-analysis. The pooled sensitivity and specificity of DECT were 84.7% (95% confidence interval [CI]: 81.3-87.7) and 93.7% (93.0-96.3), respectively. The positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 9.882 (6.122-15.95), 0.163 (0.097-0.272), and 78.10 (31.14-195.84), respectively. The area under the curve of DECT was 0.956 and the Q * index was 0.889, indicating a high diagnostic accuracy. Some between-study heterogeneity was found in the meta-analyses. However, there was no evidence of a threshold effect (Spearman correlation coefficient = 0.419; p = 0.035). In addition, meta-regression showed that the sample size, study design, and diagnostic criteria were not sources of heterogeneity, and subgroup meta-analyses did not change the overall diagnostic accuracy. Our meta-analysis of published studies demonstrates that DECT has a high diagnostic accuracy and plays an important role in the diagnosis of gout. Copyright © 2017 Elsevier Inc. All rights reserved.

  15. Environmental Sustainability Analysis of Biodiesel Production

    DEFF Research Database (Denmark)

    Herrmann, Ivan Tengbjerg; Hauschild, Michael Michael Zwicky; Birkved, Morten

    Due to their generally positive carbon dioxide balance, biofuels are seen as one of the energy carriers in a more sustainable future transportation energy system, but how good is their environmental sustainability, and where lie the main potentials for improvement of their sustainability? Questions...... like these require a life cycle perspective on the biofuel - from the cradle (production of the agricultural feedstock) to the grave (use as fuel). An environmental life cycle assessment is performed on biodiesel to compare different production schemes including chemical and enzymatic esterification...... with the use of methanol or ethanol. The life cycle assessment includes all processes needed for the production, distribution and use of the biodiesel (the product system), and it includes all relevant environmental impacts from the product system, ranging from global impacts like climate change and loss...

  16. Analysis of a quality assurance program in diagnostic radiology

    International Nuclear Information System (INIS)

    Goethlin, J.H.

    1986-01-01

    Retake analysis before and after introduction of a quality assurance program showed a 45% reduction of the retake rate. The most important changes concerning equipment and organizing of labour were: (1) More detailed inspection of development machines and X-ray generators, (2) new cassettes and intensifying screens, (3) reduction of the number of film formats used, (4) information and instruction of personnel. Cost reductions and profit from increased examination rate amounted to 4.5% of the overall operating costs of the radiologic department. (author)

  17. The market trend analysis and prospects of cancer molecular diagnostics kits.

    Science.gov (United States)

    Seo, Ju Hwan; Lee, Joon Woo; Cho, Daemyeong

    2018-01-01

    The molecular diagnostics market can be broadly divided into PCR (rt-PCR, d-PCR), NGS(Next Generation Sequencing), Microarray, FISH(Fluorescent in situ-hybridization) and other categories, based on the diagnostic technique. Also, depending on the disease being diagnosed, the market can also be divided into cancer, infectious diseases, HIV/STDs (herpes, syphilis), and women's health issues such as breast cancer, cervical cancer, ovarian cancer, HPV(human papillomavirus), and vaginitis.Chromosome analysis (including Fluorescent In-situ Hybridization) is one type of blood cancer diagnostic method, which involves the direct detection of individual cells with chromosomal translocation, but there have been problems of sensitivity when using this method. PCR targeting individual genes or the RT (reverse transcription)-PCR method offers outstanding sensitivity, but one drawback is the risk of false-positive reaction caused by contamination of samples, etc. Blood cancer molecular diagnostics kits allow us to overcome these shortcomings, and related products have been under development, with a focus on improving detection sensitivity, enabling multiple tests, and reducing the cost and diagnostic time. Blood cancer molecular diagnostics is usually performed based on platforms such as PCR. The global market for blood cancer molecular diagnostics kits is $ 335.9 million as of 2016 and is expected to reach $ 6980 million in 2026 with an average annual growth rate of 32.9%. The market in South Korea is anticipated to grow at an average annual rate of 28.9%, from $ 3.75 million as of 2016 to $ 60.89 million in 2026. The Market for blood cancer molecular diagnostics kits is judged to be higher in growth possibility due to the increase in the number of cancer patients.

  18. Land use, environmental change, and sustainable development: The role of institutional diagnostics

    Directory of Open Access Journals (Sweden)

    Oran Young

    2011-02-01

    Full Text Available Although the “tragedy of the commons” is common currency in popular accounts of problems arising in human-environment relations, empirical research has shown that common-property systems do not always lead to tragic outcomes. Moreover, systems of private property or public property, often proposed as solutions to the tragedy of the commons, can generate tragedies of their own that are equally severe. The challenge we face is to develop strategies for avoiding these tragedies featuring structures of property rights that are most likely to lead to sustainable outcomes in specific situations ranging from local communities reliant on the harvest of renewable resources to the global system facing the prospect of climate change. Successful governance systems typically involve regulatory, top-down strategies, normative, bottom-up strategies, or some combination of the two. What is needed to achieve sustainable results is a­ diagnostic approach that matches institutions to specific biophysical and socioeconomic conditions in contrast to an ideological approach that advocates the application of one system of property rights to all situations.

  19. IR spectral analysis for the diagnostics of crust earthquake precursors

    Directory of Open Access Journals (Sweden)

    R. M. Umarkhodgaev

    2012-11-01

    Full Text Available Some possible physical processes are analysed that cause, under the condition of additional ionisation in a pre-breakdown electric field, emissions in the infrared (IR interval. The atmospheric transparency region of the IR spectrum at wavelengths of 7–15 μm is taken into account. This transparency region corresponds to spectral lines of small atmospheric constituents like CH4, CO2, N2O, NO2, NO, and O3. The possible intensities of the IR emissions observable in laboratories and in nature are estimated. The acceleration process of the electrons in the pre-breakdown electrical field before its adhesion to the molecules is analyzed. For daytime conditions, modifications of the adsorption spectra of the scattered solar emissions are studied; for nighttime, variations of emission spectra may be used for the analysis.

  20. Diagnostic accuracy of atypical p-ANCA in autoimmune hepatitis using ROC- and multivariate regression analysis.

    Science.gov (United States)

    Terjung, B; Bogsch, F; Klein, R; Söhne, J; Reichel, C; Wasmuth, J-C; Beuers, U; Sauerbruch, T; Spengler, U

    2004-09-29

    Antineutrophil cytoplasmic antibodies (atypical p-ANCA) are detected at high prevalence in sera from patients with autoimmune hepatitis (AIH), but their diagnostic relevance for AIH has not been systematically evaluated so far. Here, we studied sera from 357 patients with autoimmune (autoimmune hepatitis n=175, primary sclerosing cholangitis (PSC) n=35, primary biliary cirrhosis n=45), non-autoimmune chronic liver disease (alcoholic liver cirrhosis n=62; chronic hepatitis C virus infection (HCV) n=21) or healthy controls (n=19) for the presence of various non-organ specific autoantibodies. Atypical p-ANCA, antinuclear antibodies (ANA), antibodies against smooth muscles (SMA), antibodies against liver/kidney microsomes (anti-Lkm1) and antimitochondrial antibodies (AMA) were detected by indirect immunofluorescence microscopy, antibodies against the M2 antigen (anti-M2), antibodies against soluble liver antigen (anti-SLA/LP) and anti-Lkm1 by using enzyme linked immunosorbent assays. To define the diagnostic precision of the autoantibodies, results of autoantibody testing were analyzed by receiver operating characteristics (ROC) and forward conditional logistic regression analysis. Atypical p-ANCA were detected at high prevalence in sera from patients with AIH (81%) and PSC (94%). ROC- and logistic regression analysis revealed atypical p-ANCA and SMA, but not ANA as significant diagnostic seromarkers for AIH (atypical p-ANCA: AUC 0.754+/-0.026, odds ratio [OR] 3.4; SMA: 0.652+/-0.028, OR 4.1). Atypical p-ANCA also emerged as the only diagnostically relevant seromarker for PSC (AUC 0.690+/-0.04, OR 3.4). None of the tested antibodies yielded a significant diagnostic accuracy for patients with alcoholic liver cirrhosis, HCV or healthy controls. Atypical p-ANCA along with SMA represent a seromarker with high diagnostic accuracy for AIH and should be explicitly considered in a revised version of the diagnostic score for AIH.

  1. Environmental impact statement analysis: dose methodology

    International Nuclear Information System (INIS)

    Mueller, M.A.; Strenge, D.L.; Napier, B.A.

    1981-01-01

    Standardized sections and methodologies are being developed for use in environmental impact statements (EIS) for activities to be conducted on the Hanford Reservation. Five areas for standardization have been identified: routine operations dose methodologies, accident dose methodology, Hanford Site description, health effects methodology, and socioeconomic environment for Hanford waste management activities

  2. PIXE - Analysis for environmental and biological samples

    International Nuclear Information System (INIS)

    Baptista, G.B.

    1980-04-01

    The usefulness and accuracy of PIXE as an analytical tool in the study of trace elements in environmental samples of the Brazilian Cerrado are discussed. The report lists actual and forthcoming publications resulting from the study. The mechanism of exchange of elements in solution in water to aerosols has been investigated. For details of the procedure the reader is referred to an earlier report

  3. Approaching messy problems: strategies for environmental analysis

    Science.gov (United States)

    L. M. Reid; R. R. Ziemer; T. E. Lisle

    1996-01-01

    Environmental problems are never neatly defined. Instead, each is a tangle of interacting processes whose manifestation and interpretation are warped by the vagaries of time, weather, expectation, and economics. Each problem involves livelihoods, values, and numerous specialized disciplines. Nevertheless, federal agencies in the Pacific Northwest have been given the...

  4. Diagnostic value of WIF1 methylation for colorectal cancer: a meta-analysis

    Science.gov (United States)

    Chen, Min; Huang, Tianyi; Chen, Yuehong; Ji, Huihui; Pan, Ranran; Wang, Tiangong; Jiang, Danjie; Chen, Yanfei; Yang, Yong; Duan, Shiwei

    2018-01-01

    As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 (WIF1) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-analysis of 12 studies between 1420 CRC samples and 946 control samples showed that WIF1 hypermethylation was significantly associated with CRC (P < 0.001, OR = 30.10, 95% CI = 19.48-46.50). WIF1 hypermethylation, as a diagnostic biomarker for CRC, has a pooled sensitivity of 0.40 (95% CI: 0.37-0.42), a pooled specificity of 0.95 (95% CI: 0.93-0.96), a pooled positive-likelihood ratio (PLR) of 8.65 (95% CI, 4.47-16.73), and a pooled negative-likelihood ratio (NLR) of 0.41 (95% CI, 0.30-0.55), a diagnostic odds ratio (DOR) of 26.86 (95% CI: 15.73-45.89), and an area under the curve (AUC) of 0.9115. In conclusion, our study established that WIF1 hypermethylation might be a promising diagnostic biomarker for CRC. PMID:29435185

  5. Sensitive KIT D816V mutation analysis of blood as a diagnostic test in mastocytosis

    DEFF Research Database (Denmark)

    Kielsgaard Kristensen, Thomas; Vestergaard, Hanne; Bindslev-Jensen, Carsten

    2014-01-01

    The recent progress in sensitive KIT D816V mutation analysis suggests that mutation analysis of peripheral blood (PB) represents a promising diagnostic test in mastocytosis. However, there is a need for systematic assessment of the analytical sensitivity and specificity of the approach in order...... to establish its value in clinical use. We therefore evaluated sensitive KIT D816V mutation analysis of PB as a diagnostic test in an entire case-series of adults with mastocytosis. We demonstrate for the first time that by using a sufficiently sensitive KIT D816V mutation analysis, it is possible to detect...... the mutation in PB in nearly all adult mastocytosis patients. The mutation was detected in PB in 78 of 83 systemic mastocytosis (94%) and 3 of 4 cutaneous mastocytosis patients (75%). The test was 100% specific as determined by analysis of clinically relevant control patients who all tested negative. Mutation...

  6. Environmental analysis of higher brominated diphenyl ethers and decabromodiphenyl ethane.

    Science.gov (United States)

    Kierkegaard, Amelie; Sellström, Ulla; McLachlan, Michael S

    2009-01-16

    Methods for environmental analysis of higher brominated diphenyl ethers (PBDEs), in particular decabromodiphenyl ether (BDE209), and the recently discovered environmental contaminant decabromodiphenyl ethane (deBDethane) are reviewed. The extensive literature on analysis of BDE209 has identified several critical issues, including contamination of the sample, degradation of the analyte during sample preparation and GC analysis, and the selection of appropriate detection methods and surrogate standards. The limited experience with the analysis of deBDethane suggests that there are many commonalities with BDE209. The experience garnered from the analysis of BDE209 over the last 15 years will greatly facilitate progress in the analysis of deBDethane.

  7. Environmental analysis applied to schools. Methodologies for data acquisition

    International Nuclear Information System (INIS)

    Andriola, L.; Ceccacci, R.

    2001-01-01

    The environment analysis is the basis of environmental management for organizations and it is considered as the first step in EMAS. It allows to identify, deal with the issues and have a clear knowledge on environmental performances of organizations. Schools can be included in the organizations. Nevertheless, the complexity of environmental issues and applicable regulations makes very difficult for a school, that wants to implement an environmental management system (EMAS, ISO 14001, etc.), to face this first step. So, it has been defined an instrument, that is easy but complete and coherent with reference standard, to let schools choose their process for elaborating the initial environmental revue. This instrument consists, essentially, in cards that, if completed, facilitate the drafting of the environmental analysis report [it

  8. Statistical analysis and interpretation of prenatal diagnostic imaging studies, Part 2: descriptive and inferential statistical methods.

    Science.gov (United States)

    Tuuli, Methodius G; Odibo, Anthony O

    2011-08-01

    The objective of this article is to discuss the rationale for common statistical tests used for the analysis and interpretation of prenatal diagnostic imaging studies. Examples from the literature are used to illustrate descriptive and inferential statistics. The uses and limitations of linear and logistic regression analyses are discussed in detail.

  9. Technical Analysis of the Slosson-Diagnostic Math Screener (S-DMS)

    Science.gov (United States)

    Erford, Bradley T.; Klein, Lauren

    2007-01-01

    The Slosson-Diagnostic Math Screener (S-DMS) was designed to help identify students in Grades 1 to 8 at risk for mathematics failure. Internal consistency, test-retest reliability, item analysis, decision efficiency, convergent validity, and factorial validity of all five levels of the S-DMS were studied using 20 independent samples of students…

  10. Three-layer poly(methyl methacrylate) microsystem for analysis of lysosomal enzymes for diagnostic purposes

    DEFF Research Database (Denmark)

    Kwapiszewski, Radoslaw; Kwapiszewska, Karina; Kutter, Jörg P

    2015-01-01

    by statistical analysis including construction of a Bland-Altman plot. The approach presented can be an alternative for the currently used diagnostic procedures. The method developed has a potential for the implementation into complex microfluidic devices thus becoming a powerful tool for a high...

  11. Training for thorax diagnostics. Systematic cardiopulmonary image analysis; Trainer Thoraxdiagnostik. Systematische kardiopulmonale Bildanalyse

    Energy Technology Data Exchange (ETDEWEB)

    Kirchner, Johannes [Allgemeines Krankenhaus Hagen gem.GmbH (Germany). Klinik fuer Diagnostische und Interventionelle Radiologie

    2010-07-01

    The training book on thorax diagnostics using image analysis is supposed to be a supplement to the usual textbooks based on comprehensive experiences of radiologists. The covered issues are the following: heart insufficiency, acute/ chronic bronchitis and pulmonary emphysema; pneumonia and tuberculosis; bronchial carcinoma; lung fibrosis, sarcoidosis and pneumoconiosis, pleural effusion and pneumothorax.

  12. DIII-D Thomson Scattering Diagnostic Data Acquisition, Processing and Analysis Software

    International Nuclear Information System (INIS)

    Middaugh, K.R.; Bray, B.D.; Hsieh, C.L.; McHarg, B.B.Jr.; Penaflor, B.G.

    1999-01-01

    One of the diagnostic systems critical to the success of the DIII-D tokamak experiment is the Thomson scattering diagnostic. This diagnostic is unique in that it measures local electron temperature and density: (1) at multiple locations within the tokamak plasma; and (2) at different times throughout the plasma duration. Thomson ''raw'' data are digitized signals of scattered light, measured at different times and locations, from the laser beam paths fired into the plasma. Real-time acquisition of this data is performed by specialized hardware. Once obtained, the raw data are processed into meaningful temperature and density values which can be analyzed for measurement quality. This paper will provide an overview of the entire Thomson scattering diagnostic software and will focus on the data acquisition, processing, and analysis software implementation. The software falls into three general categories: (1) Set-up and Control: Initializes and controls all Thomson hardware and software, synchronizes with other DIII-D computers, and invokes other Thomson software as appropriate. (2) Data Acquisition and Processing: Obtains raw measured data from memory and processes it into temperature and density values. (3) Analysis: Provides a graphical user interface in which to perform analysis and sophisticated plotting of analysis parameters

  13. Managing the environmental impacts of land transport: integrating environmental analysis with urban planning

    International Nuclear Information System (INIS)

    Irving, Paul; Moncrieff, Ian

    2004-01-01

    Ecological systems have limits or thresholds that vary by pollutant type, emissions sources and the sensitivity of a given location. Human health can also indicate sensitivity. Good environmental management requires any problem to be defined to obtain efficient and effective solutions. Cities are where transport activities, effects and resource management decisions are often most focussed. The New Zealand Ministry of Transport has developed two environmental management tools. The Vehicle Fleet Model (VFM) is a predictive database of the environmental performance of the New Zealand traffic fleet (and rail fleet). It calculates indices of local air quality, stormwater, and greenhouse gases emissions. The second is an analytical process based on Environmental Capacity Analysis (ECA). Information on local traffic is combined with environmental performance data from the Vehicle Fleet Model. This can be integrated within a live, geo-spatially defined analysis of the overall environmental effects within a defined local area. Variations in urban form and activity (traffic and other) that contribute to environmental effects can be tracked. This enables analysis of a range of mitigation strategies that may contribute, now or in the future, to maintaining environmental thresholds or meeting targets. A case study of the application of this approach was conducted within Waitakere City. The focus was on improving the understanding of the relative significance of stormwater contaminants derived from land transport

  14. Environmental analysis of natural gas life cycle

    International Nuclear Information System (INIS)

    Riva, A.; D'Angelosante, S.; Trebeschi, C.

    2000-01-01

    Life Cycle Assessment is a method aimed at identifying the environmental effects connected with a given product, process or activity during its whole life cycle. The evaluation of published studies and the application of the method to electricity production with fossil fuels, by using data from published databases and data collected by the gas industry, demonstrate the importance and difficulties to have reliable and updated data required for a significant life cycle assessment. The results show that the environmental advantages of natural gas over the other fossil fuels in the final use stage increase still further if the whole life cycle of the fuels, from production to final consumption, is taken into account [it

  15. Environmental Analysis of the Groningen City Center

    OpenAIRE

    GÓMEZ BUGEDA, RICARDO SANTIAGO

    2017-01-01

    This final thesis project is part of the research that is carrying out by the Gemeente Groningen in order to make the city center more sustainable and livable. The municipality of Groningen has recently published a conceptual development plan for improving the inner-city of Groningen, this report is called Bestemming Binnenstad 01/2016 . The main focus of this report is convert the city center to an environmental friendly downtown, reducing pollution, reroute public and private transpo...

  16. Analysis of high school students’ environmental literacy

    Science.gov (United States)

    Wardani, R. A. K.; Karyanto, P.; Ramli, M.

    2018-05-01

    The student’s environmental literacy (EL) is a vital component to improve the awareness of student on environmental issues. This research aims to measure and analyse the EL of high school students, and how the topic of environment has been taught in high school. The research was conducted in February to April 2017. The EL was measured on three aspects, i.e. knowledge, attitude and concern. The participants were sixty-five (21 boys, 44 girls) purposively selected from students of grade X, XI and XII of one Senior High School in Karanganyar Regency, Indonesia. The knowledge of students on concepts of environmental issues was tested by fourteen main questions followed by supported questions. The result showed that 80% of students were classified as inadequate category. The attitude of students was measured by New Ecological Paradigm (NEP) consisted of fifteen items, and students’ average score was 46.42 (medium). The concern was measured by fifteen statements about environment, and it was ranged from 2.58 to 4.18. EL of students may low due to students’ lack understanding of the environment concepts, the limited theories and concepts transferred to students, inappropriate lesson plan to meet the EL components.

  17. Exergetic and environmental analysis of a pulverized coal power plant

    International Nuclear Information System (INIS)

    Restrepo, Álvaro; Miyake, Raphael; Kleveston, Fábio; Bazzo, Edson

    2012-01-01

    This paper presents the results of exergetic and environmental analysis of a typical pulverized coal power plant located in Brazil. The goal was to quantify both the exergy destruction and the environmental impact associated with a thermal power plant. The problem boundary consists of the entire coal delivery route, including mining and beneficiation, transport, pre-burning processes and the power plant. The used data were obtained mainly from field measurements taken in all system processes, from mining to the power plant. The study focused only on the operation period. Previous works have shown that the construction and decommissioning periods contribute less than 1% of the environmental impact. The exergetic analysis was based on the second law of thermodynamics while the environmental analysis was based on life cycle assessment (LCA) using SimaPro 7.2, focussing on the climate change and acidification impact categories. The CO 2 -eq emission was 1300 kg per MWh. The highest degree of environmental impact occurred during the combustion process. The exergetic and environmental analysis provides a tool to evaluate irreversibilities and the environmental impact, identifying the most significant stages and equipment of the entire power generation process. -- Highlights: ► Exergetic and environmental analysis of a typical Brazilian PC power plant. ► Environmental impact associated with the mining, transport and thermal power plant. ► Life cycle assessment used for environmental analysis. ► Acidification impact category evaluated using Eco-indicator 99. ► Climate change impact evaluation using (Global Warming Potential) GWP 100a.

  18. Diagnostic value of WIF1 methylation for colorectal cancer: a meta-analysis

    OpenAIRE

    Hu, Haochang; Li, Bin; Zhou, Cong; Ying, Xiuru; Chen, Min; Huang, Tianyi; Chen, Yuehong; Ji, Huihui; Pan, Ranran; Wang, Tiangong; Jiang, Danjie; Chen, Yanfei; Yang, Yong; Duan, Shiwei

    2018-01-01

    As a common antagonist of Wnt/β-catenin signaling, Wnt inhibitory factor 1 (WIF1) plays an important role in the tumor progression. The aim of our meta-analysis was to summarize the diagnostic value of WIF1 methylation in colorectal cancer (CRC). Eligible studies were retrieved by a systemic search among PubMed, Embase, CNKI, and Wanfang literature databases. The diagnostic value of WIF1 methylation for CRC was assessed by the summary receiver operating characteristics (SROC) test. Our meta-a...

  19. Qualitative Analysis of Diagnostic Value of 24-h Proteinuria for Preeclampsia

    Directory of Open Access Journals (Sweden)

    Xu Zhuang

    2015-01-01

    Full Text Available Background: Preeclampsia (PE is a serious idiopathic disease posing a threat to both mothers and fetuses′ lives during pregnancy, whose main diagnostic criteria include hypertension with proteinuria. However, American College of Obstetricians and Gynecologists (ACOG updated the diagnostic criteria for PE and reduced the diagnostic value of proteinuria for patients with PE. Qualitative analysis of the diagnostic value of 24-h proteinuria for patients with PE in China was conducted to evaluate the diagnostic criteria value in the latest ACOG guideline. Methods: Complete clinical data of 65 patients with hypertensive disorder in pregnancy (HDP were collected. All patients were delivered to and hospitalized in Renji Hospital. Adverse outcome was defined in case of the emergence of any serious complication for a mother or the fetus. A retrospective study was conducted according to ACOG guideline, to analyze the relationship between each diagnostic criteria of ACOG guideline and maternal and perinatal outcomes. Spearman correlation test was used to detect the association between each diagnostic criterion, its corresponding value, and the adverse pregnancy outcome. Logistic regression was performed to verify the result of Spearman correlation test. Results: Of 65 HDP patients, the percentage of adverse pregnancy outcome was 63.1%. Adverse pregnancy outcomes constitute diversification. There were 55 cases with 24-h proteinuria value ≥0.3 g, of which the adverse outcome rate was 74.5%. While adverse pregnancy outcomes did not appear in the rest 10 HDP patients with proteinuria <0.3 g/24 h. The statistic difference was significant (P = 0.000. However, no significant difference was found in other criteria groups (impaired liver function: P = 0.417; renal insufficiency: P = 0.194; thrombocytopenia: P = 0.079; and cerebral or visual symptoms: P = 0.296. The correlation coefficient between 24-h proteinuria ≥0.3 g and adverse pregnancy outcomes was 0

  20. Diagnostic Performance of Mammographic Texture Analysis in the Differential Diagnosis of Benign and Malignant Breast Tumors.

    Science.gov (United States)

    Li, Zhiming; Yu, Lan; Wang, Xin; Yu, Haiyang; Gao, Yuanxiang; Ren, Yande; Wang, Gang; Zhou, Xiaoming

    2017-11-09

    The purpose of this study was to investigate the diagnostic performance of mammographic texture analysis in the differential diagnosis of benign and malignant breast tumors. Digital mammography images were obtained from the Picture Archiving and Communication System at our institute. Texture features of mammographic images were calculated. Mann-Whitney U test was used to identify differences between the benign and malignant group. The receiver operating characteristic (ROC) curve analysis was used to assess the diagnostic performance of texture features. Significant differences of texture features of histogram, gray-level co-occurrence matrix (GLCM) and run length matrix (RLM) were found between the benign and malignant breast group (P  .05). The AUROCs of imaging-based diagnosis, texture analysis, and imaging-based diagnosis combined with texture analysis were 0.873, 0.863, and 0.961, respectively. When imaging-based diagnosis was combined with texture analysis, the AUROC was higher than that of imaging-based diagnosis or texture analysis (P benign and malignant breast tumors. Furthermore, the combination of imaging-based diagnosis and texture analysis can significantly improve diagnostic performance. Copyright © 2017 Elsevier Inc. All rights reserved.

  1. [Methods of statistical analysis in differential diagnostics of the degree of brain glioma anaplasia during preoperative stage].

    Science.gov (United States)

    Glavatskiĭ, A Ia; Guzhovskaia, N V; Lysenko, S N; Kulik, A V

    2005-12-01

    The authors proposed a possible preoperative diagnostics of the degree of supratentorial brain gliom anaplasia using statistical analysis methods. It relies on a complex examination of 934 patients with I-IV degree anaplasias, which had been treated in the Institute of Neurosurgery from 1990 to 2004. The use of statistical analysis methods for differential diagnostics of the degree of brain gliom anaplasia may optimize a diagnostic algorithm, increase reliability of obtained data and in some cases avoid carrying out irrational operative intrusions. Clinically important signs for the use of statistical analysis methods directed to preoperative diagnostics of brain gliom anaplasia have been defined

  2. Common faults in turbines and applying neural networks in order to fault diagnostic by vibration analysis

    International Nuclear Information System (INIS)

    Masoudifar, M.; AghaAmini, M.

    2001-01-01

    Today the fault diagnostic of the rotating machinery based on the vibration analysis is an effective method in designing predictive maintenance programs. In this method, vibration level of the turbines is monitored and if it is higher than the allowable limit, vibrational data will be analyzed and the growing faults will be detected. But because of the high complexity of the system monitoring, the interpretation of the measured data is more difficult. Therefore, design of the fault diagnostic expert systems by using the expert's technical experiences and knowledge; seem to be the best solution. In this paper,at first several common faults in turbines are studied and the how applying the neural networks to interpret the vibrational data for fault diagnostic is explained

  3. Bayesian analysis of longitudinal Johne's disease diagnostic data without a gold standard test

    DEFF Research Database (Denmark)

    Wang, C.; Turnbull, B.W.; Nielsen, Søren Saxmose

    2011-01-01

    the posterior estimates of the model parameters that provide the basis for inference concerning the accuracy of the diagnostic procedure. Based on the Bayesian approach, the posterior probability distribution of the change-point onset time can be obtained and used as a criterion for infection diagnosis......-point process with a Weibull survival hazard function was used to model the progression of the hidden disease status. The model adjusted for the fixed effects of covariate variables and random effects of subject on the diagnostic testing procedure. Markov chain Monte Carlo methods were used to compute....... An application is presented to an analysis of ELISA and fecal culture test outcomes in the diagnostic testing of paratuberculosis (Johne's disease) for a Danish longitudinal study from January 2000 to March 2003. The posterior probability criterion based on the Bayesian model with 4 repeated observations has...

  4. An update on the use of cerebrospinal fluid analysis as a diagnostic tool in multiple sclerosis.

    Science.gov (United States)

    Gastaldi, Matteo; Zardini, Elisabetta; Franciotta, Diego

    2017-01-01

    Intrathecal B-lymphocyte activation is a hallmark of multiple sclerosis (MS), a multi-factorial inflammatory-demyelinating disease of the central nervous system. Such activation has a counterpart in the cerebrospinal fluid (CSF) oligoclonal IgG bands (OCB), whose diagnostic role in MS has been downgraded within the current McDonald's criteria. With a theoretico-practical approach, the authors review the physiopathological basis of the CSF dynamics, and the state-of-the-art of routine CSF analysis and CSF biomarkers in MS. Areas covered: The authors discuss pros and cons of CSF analysis, including critical evaluations of both well-established, and promising diagnostic and prognostic laboratory tools. New acquisitions on the CSF and cerebral interstitial fluid dynamics are also presented. The authors searched the PubMed database for English-language articles reported between January 2010 and June 2016, using the key words 'multiple sclerosis', 'cerebrospinal fluid', 'oligoclonal bands'. Reference lists of relevant articles were scanned for additional studies. Expert commentary: The availability of performing high-quality, routine CSF tests in specialized laboratories, the emerging potential of novel CSF biomarkers, and the trend for early treatments should induce a reappraisal of CSF analysis for diagnostic and prognostic purposes in MS. Further procedural and methodological improvements seem to be necessary in both research and translational diagnostic CSF settings.

  5. Variations analysis of the Society's preference structure regarding environmental issues

    International Nuclear Information System (INIS)

    Angel S, Enrique; Zambrano B, Ana Maria

    2005-01-01

    Society's preference structure regarding environmental issues is understood as the relative importance the society gives to various topics that collectively conform the environmental issues. Based on the hypothesis that this structure behavior and its definition vary with time, proposals are presented related to the concepts and a working plan allowing performing the structure's dynamic analysis. A method is described to gather information based on the systematic reading of a nation wide newspaper during a period time. A comparison is done between the resulting structure and several aspects as the environmental legislation, government plans and summits and environmental milestones

  6. Environmental analysis by electrochemical sensors and biosensors fundamentals

    CERN Document Server

    Moretto, Ligia Maria

    2014-01-01

    This book presents an exhaustive overview of electrochemical sensors and biosensors for the analysis and monitoring of the most important analytes in the environmental field, in industry, in treatment plants and in environmental research. The chapters give the reader a comprehensive, state-of-the-art picture of the field of electrochemical sensors suitable to environmental analytes, from the theoretical principles of their design to their implementation, realization and application. The first three chapters discuss fundamentals, and the last three chapters cover the main groups of analytes of environmental interest.

  7. Analysis of Chronic Temporomandibular Disorders Based on the Latest Diagnostic Criteria

    Directory of Open Access Journals (Sweden)

    Svechtarov V.

    2015-05-01

    Full Text Available The objective of this study is to analyze the distribution of the most common diagnoses observed in patients with chronic temporomandibular disorders, based on the new diagnostic criteria (DC/TMD adopted in 2014. The previous Research Diagnostic Criteria (RDC/TMD adopted in 1992, consisted of three main groups of eight diagnostic subgroups and is currently transformed into two main groups and twelve subgroups, respectively. All subgroups correspond to the nomenclature of the ICD-10. The new clinical diagnostic indices are also modified. The analysis showed a prevalence of Pain-Related TMD compared with that of intra-articular disorders in ratio 57.89% to 42.10%. In Pain-Related TMD arthralgia was represented in 55% of cases; local myalgia - in 12%, myofascial pain - in 18%, myofascial pain with referral - in 14%, headache attributed to TMD - in 1%. In Intra-articular TMD disc displacement with reduction was found in 23% of the cases, disc displacement with reduction with intermittent locking - in 3%, disc displacement without reduction with limited opening - in 25%, disc displacement without reduction and without limited opening - in 8%. Degenerative diseases were found in 14.28%, and hypermobility and subluxations - in 26.98%. These analyzes differ and can only partly be compared with previous analyzes based on RDC system. The changes in the diagnostic criteria require new clinical studies in order to refine the picture of temporomandibular pathology in accordance with the modern views on the matter.

  8. Admixture analysis of the diagnostic subtypes of social anxiety disorder: implications for the DSM-V.

    Science.gov (United States)

    Aderka, Idan M; Nickerson, Angela; Hofmann, Stefan G

    2012-06-01

    Much controversy exists regarding diagnostic subtypes of social anxiety disorder (SAD). The present study used admixture analysis to examine whether individuals with generalized and nongeneralized SAD belong to the same or different populations of origin. This can inform diagnostic subtyping of SAD in the forthcoming DSM-V. Treatment-seeking individuals with generalized SAD (n = 154) and nongeneralized SAD (n = 48) completed a battery of questionnaires. Based on participants' responses to the Liebowitz Social Anxiety Scale (LSAS), we estimated log likelihood and chi-square goodness-of-fit for models with 1, 2, 3, or 4 populations of origin, and compared models using forward stepwise estimation and maximum likelihood ratio tests. Admixture analyses suggested that the two diagnostic subtypes of SAD belong to the same underlying population of origin. In addition, observable differences in depression, general anxiety, and comorbidity were no longer significant when controlling for social anxiety severity. Our sample was recruited in the U.S. and was a treatment-seeking sample. Future studies should examine whether our results generalize to different cultures, and community samples. Support for qualitative differences between SAD subtypes was not found. Rather, our findings support the notion that the diagnostic subtypes of SAD differ quantitatively, and that SAD exists on a continuum of severity. This finding informs diagnostic subtyping of SAD in the forthcoming DSM-V. Copyright © 2011 Elsevier Ltd. All rights reserved.

  9. Environmental impact analysis of aquaculture in net cages in a ...

    African Journals Online (AJOL)

    Environmental impact analysis of aquaculture in net cages in a Brazilian water reservoir, based in zooplankton communities. Maria Cristina Crispim, Karla Patrícia Ponte Araújo, Hênio do Nascimento Melo Júnior ...

  10. Risk Analysis for Environmental Health Triage

    International Nuclear Information System (INIS)

    Bogen, K T

    2005-01-01

    The Homeland Security Act mandates development of a national, risk-based system to support planning for, response to and recovery from emergency situations involving large-scale toxic exposures. To prepare for and manage consequences effectively, planners and responders need not only to identify zones of potentially elevated individual risk, but also to predict expected casualties. Emergency response support systems now define ''consequences'' by mapping areas in which toxic chemical concentrations do or may exceed Acute Exposure Guideline Levels (AEGLs) or similar guidelines. However, because AEGLs do not estimate expected risks, current unqualified claims that such maps support consequence management are misleading. Intentionally protective, AEGLs incorporate various safety/uncertainty factors depending on scope and quality of chemical-specific toxicity data. Some of these factors are irrelevant, and others need to be modified, whenever resource constraints or exposure-scenario complexities require responders to make critical trade-off (triage) decisions in order to minimize expected casualties. AEGL-exceedance zones cannot consistently be aggregated, compared, or used to calculate expected casualties, and so may seriously misguide emergency response triage decisions. Methods and tools well established and readily available to support environmental health protection are not yet developed for chemically related environmental health triage. Effective triage decisions involving chemical risks require a new assessment approach that focuses on best estimates of likely casualties, rather than on upper plausible bounds of individual risk. If risk-based consequence management is to become a reality, federal agencies tasked with supporting emergency response must actively coordinate to foster new methods that can support effective environmental health triage

  11. Diagnostic Performance of Narrow Band Imaging for Laryngeal Cancer: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Sun, Changling; Han, Xue; Li, Xiaoying; Zhang, Yayun; Du, Xiaodong

    2017-04-01

    Objective To evaluate the performance of narrow band imaging (NBI) for the diagnosis of laryngeal cancer and to compare the diagnostic value of NBI with that of white light endoscopy. Data Sources PubMed, Embase, Cochrane Library, and CNKI databases. Review Methods Data analyses were performed with Meta-DiSc. The updated Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality and potential bias. Publication bias was assessed with the Deeks's asymmetry test. The protocol used in this article has been published on PROSPERO and is in accordance with the PRISMA checklist. The registry number for this study is CRD42015025866. Results Six studies including 716 lesions were included in this meta-analysis. The pooled sensitivity, specificity, and diagnostic odds ratio for the NBI diagnosis of laryngeal cancer were 0.94 (95% confidence interval [95% CI]: 0.91-0.96), 0.89 (95% CI: 0.85-0.92), and 142.12 (95% CI: 46.42-435.15), respectively, and the area under receiver operating characteristics curve was 0.97. Among the 6 studies, 3 evaluated the diagnostic value of white light endoscopy, with a sensitivity of 0.81 (95% CI: 0.76-0.86), a specificity of 0.92 (95% CI: 0.88-0.95), and a diagnostic odds ratio of 33.82 (95% CI: 14.76-77.49). The evaluation of heterogeneity, calculated per the diagnostic odds ratio, gave an I 2 of 66%. No marked publication bias ( P = .84) was detected in this meta-analysis. Conclusion The sensitivity of NBI is superior to white light endoscopy, and the potential value of NBI needs to be validated in future studies.

  12. Coherent Energy and Environmental System Analysis

    DEFF Research Database (Denmark)

    Hvelplund, Frede Kloster; Mathiesen, Brian Vad; Østergaard, Poul Alberg

    This report presents a summary of results of the strategic research project “Coherent Energy and Environmental System Analysis” (CEESA) which was conducted in the period 2007-2011 and funded by the Danish Strategic Research Council together with the participating parties. The project...... was interdisciplinary and involved more than 20 researchers from 7 different university departments or research institutions in Denmark. Moreover, the project was supported by an international advisory panel. The results include further development and integration of existing tools and methodologies into coherent...

  13. Potential diagnostic value of serum p53 antibody for detecting colorectal cancer: A meta-analysis.

    Science.gov (United States)

    Meng, Rongqin; Wang, Yang; He, Liang; He, Yuanqing; Du, Zedong

    2018-04-01

    Numerous studies have assessed the diagnostic value of serum p53 (s-p53) antibody in patients with colorectal cancer (CRC); however, results remain controversial. The present study aimed to comprehensively and quantitatively summarize the potential diagnostic value of s-p53 antibody in CRC. The present study utilized databases, including PubMed and EmBase, systematically regarding s-p53 antibody diagnosis in CRC, accessed on and prior to 31 July 2016. The quality of all the included studies was assessed using quality assessment of studies of diagnostic accuracy (QUADAS). The result of pooled sensitivity, pooled specificity, positive likelihood ratio (PLR) and negative likelihood ratio (NLR) were analyzed and compared with overall accuracy measures using diagnostic odds ratios (DORs) and area under the curve (AUC) analysis. Publication bias and heterogeneity were also assessed. A total of 11 trials that enrolled a combined 3,392 participants were included in the meta-analysis. Approximately 72.73% (8/11) of the included studies were of high quality (QUADAS score >7), and all were retrospective case-control studies. The pooled sensitivity was 0.19 [95% confidence interval (CI), 0.18-0.21] and pooled specificity was 0.93 (95% CI, 0.92-0.94). Results also demonstrated a PLR of 4.56 (95% CI, 3.27-6.34), NLR of 0.78 (95% CI, 0.71-0.85) and DOR of 6.70 (95% CI, 4.59-9.76). The symmetrical summary receiver operating characteristic curve was 0.73. Furthermore, no evidence of publication bias or heterogeneity was observed in the meta-analysis. Meta-analysis data indicated that s-p53 antibody possesses potential diagnostic value for CRC. However, discrimination power was somewhat limited due to the low sensitivity.

  14. Environmental impact analysis of mine tailing reservoir

    Science.gov (United States)

    Gong, J. Z.

    2016-08-01

    Under certain conditions landscape topography which utilizes mine tailing reservoir construction using is likely to increase lateral recharge source regions, resulting in dramatic changes to the local hydrological dynamic field and recharge of downstream areas initiated by runoff, excretion state, elevated groundwater depth, shallow groundwater, rainfall direct communication, and thinning of the vadose zone. Corrosive leaching of topsoil over many years of exposure to chemical fertilizers and pesticides may result in their dissolution into the groundwater system, which may lead to excessive amounts of many harmful chemicals, therby affecting the physical and mental health of human residents and increase environmental vulnerability and risk associated with the water and soil. According to field survey data from Yujiakan, Qian'an City, and Hebei provinces, this paper analyzes the hydrogeological environmental mechanisms of areas adjacent to mine tailing reservoirs and establishes a conceptual model of the local groundwater system and the concentration-response function between NO3 - content in groundwater and the incidence of cancer in local residents.

  15. Human reliability analysis during PSA at Trillo NPP: main characteristics and analysis of diagnostic errors

    International Nuclear Information System (INIS)

    Barquin, M.A.; Gomez, F.

    1998-01-01

    The design difference between Trillo NPP and other Spanish nuclear power plants (basic Westinghouse and General Electric designs) were made clear in the Human Reliability Analysis of the Probabilistic Safety Analysis (PSA) for Trillo NPP. The object of this paper is to describe the most significant characteristics of the Human Reliability Analysis carried out in the PSA, with special emphasis on the possible diagnostic errors and their consequences, based on the characteristics in the Emergency Operations Manual for Trillo NPP. - In the case of human errors before the initiating event (type 1), the existence of four redundancies in most of the plant safety systems, means that the impact of this type or error on the final results of the PSA is insignificant. However, in the case common cause errors, especially in certain calibration errors, some actions are significant in the final equation for core damage - The number of human actions that the operator has to carry out during the accidents (type 3) modelled, is relatively small in comparison with this value in other PSAs. This is basically due to the high level of automation at Rillo NPP - The Plant Operations Manual cannot be strictly considered to be a symptoms-based procedure. The operation Group must select the chapter from the Operations Manual to be followed, after having diagnosed the perturbing event, using for this purpose and Emergency and Anomaly Decision Tree (M.O.3.0.1) based on the different indications, alarms and symptoms present in the plant after the perturbing event. For this reason, it was decided to analyse the possible diagnosis errors. In the bibliography on diagnosis and commission errors available at the present time, there is no precise methodology for the analysis of this type of error and its incorporation into PSAs. The method used in the PSA for Trillo y NPP to evaluate this type of interaction, is to develop a Diagnosis Error Table, the object of which is to identify the situations in

  16. Environmental Performance in Countries Worldwide: Determinant Factors and Multivariate Analysis

    Directory of Open Access Journals (Sweden)

    Isabel Gallego-Alvarez

    2014-11-01

    Full Text Available The aim of this study is to analyze the environmental performance of countries and the variables that can influence it. At the same time, we performed a multivariate analysis using the HJ-biplot, an exploratory method that looks for hidden patterns in the data, obtained from the usual singular value decomposition (SVD of the data matrix, to contextualize the countries grouped by geographical areas and the variables relating to environmental indicators included in the environmental performance index. The sample used comprises 149 countries of different geographic areas. The findings obtained from the empirical analysis emphasize that socioeconomic factors, such as economic wealth and education, as well as institutional factors represented by the style of public administration, in particular control of corruption, are determinant factors of environmental performance in the countries analyzed. In contrast, no effect on environmental performance was found for factors relating to the internal characteristics of a country or political factors.

  17. Full Life Cycle of Data Analysis with Climate Model Diagnostic Analyzer (CMDA)

    Science.gov (United States)

    Lee, S.; Zhai, C.; Pan, L.; Tang, B.; Zhang, J.; Bao, Q.; Malarout, N.

    2017-12-01

    We have developed a system that supports the full life cycle of a data analysis process, from data discovery, to data customization, to analysis, to reanalysis, to publication, and to reproduction. The system called Climate Model Diagnostic Analyzer (CMDA) is designed to demonstrate that the full life cycle of data analysis can be supported within one integrated system for climate model diagnostic evaluation with global observational and reanalysis datasets. CMDA has four subsystems that are highly integrated to support the analysis life cycle. Data System manages datasets used by CMDA analysis tools, Analysis System manages CMDA analysis tools which are all web services, Provenance System manages the meta data of CMDA datasets and the provenance of CMDA analysis history, and Recommendation System extracts knowledge from CMDA usage history and recommends datasets/analysis tools to users. These four subsystems are not only highly integrated but also easily expandable. New datasets can be easily added to Data System and scanned to be visible to the other subsystems. New analysis tools can be easily registered to be available in the Analysis System and Provenance System. With CMDA, a user can start a data analysis process by discovering datasets of relevance to their research topic using the Recommendation System. Next, the user can customize the discovered datasets for their scientific use (e.g. anomaly calculation, regridding, etc) with tools in the Analysis System. Next, the user can do their analysis with the tools (e.g. conditional sampling, time averaging, spatial averaging) in the Analysis System. Next, the user can reanalyze the datasets based on the previously stored analysis provenance in the Provenance System. Further, they can publish their analysis process and result to the Provenance System to share with other users. Finally, any user can reproduce the published analysis process and results. By supporting the full life cycle of climate data analysis

  18. Environmental risk analysis for offshore oil and gas activities

    Energy Technology Data Exchange (ETDEWEB)

    Brude, Odd Willy; Aspholm, Ole O.; Rudberg, Anders [Det Norske Veritas (Brazil)

    2008-07-01

    Offshore oil and gas activities always have a risk for environmental impact due to potential accidental releases of oil and gas. The environmental risk can be calculated as a combination of the frequency of such accidents to occur and their environmental consequences in terms of environmental damage to habitats or populations. A method for conducting environmental risk analysis has been in use in Norwegian offshore waters for a decade, with a continuously refinement of methodology over the past years. This paper outlines the principles in the MIRA method and gives examples and discussions regarding use in different environmental compartments. The risk assessment starts with identification of oil spill scenarios with frequencies of potential release rates and spill durations. The next step is to model the oil drift for each accidental oil spill scenario. Drift and fate of oil is modeled probabilistic. Based on the oil spill scenarios and their probability of oil pollution, the potential environmental damage is quantified for each scenario. The endpoint of environmental damage is reduction of a population and the resulting recovery time (in years) for various species and habitats. Environmental risk levels are then evaluated against the operating companies' environmental acceptance criteria. (author)

  19. Ocean Thermal Energy Conversion (OTEC) Programmatic Environmental Analysis--Appendices

    Energy Technology Data Exchange (ETDEWEB)

    Authors, Various

    1980-01-01

    The programmatic environmental analysis is an initial assessment of Ocean Thermal Energy Conversion (OTEC) technology considering development, demonstration and commercialization. It is concluded that the OTEC development program should continue because the development, demonstration, and commercialization on a single-plant deployment basis should not present significant environmental impacts. However, several areas within the OTEC program require further investigation in order to assess the potential for environmental impacts from OTEC operation, particularly in large-scale deployments and in defining alternatives to closed-cycle biofouling control: (1) Larger-scale deployments of OTEC clusters or parks require further investigations in order to assess optimal platform siting distances necessary to minimize adverse environmental impacts. (2) The deployment and operation of the preoperational platform (OTEC-1) and future demonstration platforms must be carefully monitored to refine environmental assessment predictions, and to provide design modifications which may mitigate or reduce environmental impacts for larger-scale operations. These platforms will provide a valuable opportunity to fully evaluate the intake and discharge configurations, biofouling control methods, and both short-term and long-term environmental effects associated with platform operations. (3) Successful development of OTEC technology to use the maximal resource capabilities and to minimize environmental effects will require a concerted environmental management program, encompassing many different disciplines and environmental specialties. This volume contains these appendices: Appendix A -- Deployment Scenario; Appendix B -- OTEC Regional Characterization; and Appendix C -- Impact and Related Calculations.

  20. OCEAN THERMAL ENERGY CONVERSION (OTEC) PROGRAMMATIC ENVIRONMENTAL ANALYSIS

    Energy Technology Data Exchange (ETDEWEB)

    Sands, M. D.

    1980-01-01

    This programmatic environmental analysis is an initial assessment of OTEC technology considering development, demonstration and commercialization; it is concluded that the OTEC development program should continue because the development, demonstration, and commercialization on a single-plant deployment basis should not present significant environmental impacts. However, several areas within the OTEC program require further investigation in order to assess the potential for environmental impacts from OTEC operation, particularly in large-scale deployments and in defining alternatives to closed-cycle biofouling control: (1) Larger-scale deployments of OTEC clusters or parks require further investigations in order to assess optimal platform siting distances necessary to minimize adverse environmental impacts. (2) The deployment and operation of the preoperational platform (OTEC-1) and future demonstration platforms must be carefully monitored to refine environmental assessment predictions, and to provide design modifications which may mitigate or reduce environmental impacts for larger-scale operations. These platforms will provide a valuable opportunity to fully evaluate the intake and discharge configurations, biofouling control methods, and both short-term and long-term environmental effects associated with platform operations. (3) Successful development of OTEC technology to use the maximal resource capabilities and to minimize environmental effects will require a concerted environmental management program, encompassing many different disciplines and environmental specialties.

  1. Use of a tandem accelerator in the basic studies on nuclear fusion and environmental diagnostics

    International Nuclear Information System (INIS)

    Oguri, Yoshiyuki; Hasegawa, Jun; Fukuda, Hitoshi; Ogawa, Masao

    2001-01-01

    A small tandem electrostatic accelerator has worked well 16 years after installation. In the last year, however, a pellet chain touched to inductor and a considerable amount of metallic powder was sprayed inside the pressure vessel. Basic experiments have been made on the interaction of plasma and heavy ion beams. Stopping powers of a plasma produced by laser irradiation were measured as a function of the injection energy. In addition, fabrication of solid hydrogen targets has been tried. PIXE analysis has been applied to air pollution in monitoring a long major roads. In addition preparatory treatments and procedures for thick samples are tested. (M. Tanaka)

  2. Continuous data acquisition with online analysis for the Wendelstein 7-X magnetic diagnostics

    International Nuclear Information System (INIS)

    Hennig, Ch.; Werner, A.; Marquardt, M.; Bluhm, T.; Kroiss, H.; Kuehner, G.; Heimann, P.; Maier, J.; Riemann, H.; Zilker, M.

    2008-01-01

    The coupling of continuous data acquisition and continuous online analysis keeping up with the acquisition is one of the features the W7-X data acquisition system is designed for. As proof of principle of this concept the magnetic diagnostics have been implemented. The magnetic diagnostics measure time derivatives of the magnetic fluxes and the signals have to be time integrated accordingly. Both measurement and analysis tasks are executed on a single PC based system. The configuration of both hard- and software of the system is presented. Special focuses are the task of software integration of a user supplied online analysis function into the data acquisition system and the incorporation of the complete system into the W7-X segment concept in use by the control system. The complete installation has been tested at the WEGA Stellarator experiment. Because WEGA is capable of continuous steady state plasma operation the practical suitability of the installation for W7-X could be demonstrated successfully

  3. Diagnostics of oral lichen planus based on analysis of volatile organic compounds in saliva

    Science.gov (United States)

    Kistenev, Yury; Borisov, Alexey; Shapovalov, Alexander; Baydik, Olga; Titarenko, Maria

    2017-03-01

    The ability of diagnostics of oral lichen planus (OLP) based on spectral analysis of saliva using the THz spectroscopy is presented. The study included 8 patients with clinically proven OLP. The comparison group consisted of 8 healthy volunteers. Absorption spectra of the saliva was measured using time-domain spectrometer T-spec (EXPLA) in the range 0.2-3THz and have been considered as the feature vectors of the state. The spatial distribution of the objects under study in the feature space was analyzed using principle component analysis. The groups under study were shown to separate in full. Thus, the saliva analysis by the THz spectroscopy technique can be potentially used as a method of noninvasive diagnostics of the OLP.

  4. Cost-Effectiveness Analysis of Helicobacter pylori Diagnostic Methods in Patients with Atrophic Gastritis

    Directory of Open Access Journals (Sweden)

    Fumio Omata

    2017-01-01

    Full Text Available Background. There are several diagnostic methods for Helicobacter pylori (H. pylori infection. A cost-effective analysis is needed to decide on the optimal diagnostic method. The aim of this study was to determine a cost-effective diagnostic method in patients with atrophic gastritis (AG. Methods. A decision-analysis model including seven diagnostic methods was constructed for patients with AG diagnosed by esophagogastroduodenoscopy. Expected values of cost and effectiveness were calculated for each test. Results. If the prevalence of H. pylori in the patients with AG is 85% and CAM-resistant H. pylori is 30%, histology, stool H. pylori antigen (SHPAg, bacterial culture (BC, and urine H. pylori antibody (UHPAb were dominated by serum H. pylori IgG antibody (SHPAb, rapid urease test (RUT, and urea breath test (UBT. Among three undominated methods, the incremental cost-effective ratios (ICER of RUT versus SHPAb and UBT versus RUT were $214 and $1914, respectively. If the prevalence of CAM-sensitive H. pylori was less than 55%, BC was not dominated, but its H. pylori eradication success rate was 0.86. Conclusions. RUT was the most cost-effective at the current prevalence of CAM-resistant H. pylori. BC could not be selected due to its poor effectiveness even if CAM-resistant H. pylori was more than 45%.

  5. Regional analysis and environmental impact assessment

    International Nuclear Information System (INIS)

    Parzyck, D.C.; Brocksen, R.W.; Emanuel, W.R.

    1976-01-01

    This paper presents a number of techniques that can be used to assess environmental impacts on a regional scale. Regional methodologies have been developed which examine impacts upon aquatic and terrestrial biota in regions through consideration of changes in land use, land cover, air quality, water resource use, and water quality. Techniques used to assess long-range atmospheric transport, water resources, effects on sensitive forest and animal species, and impacts on man are presented in this paper, along with an optimization approach which serves to integrate the analytical techniques in an overall assessment framework. A brief review of the research approach and certain modeling techniques used within one regional studies program is provided. While it is not an all inclusive report on regional analyses, it does present an illustration of the types of analyses that can be performed on a regional scale

  6. Environmental behavior and analysis of agricultural sulfur.

    Science.gov (United States)

    Griffith, Corey M; Woodrow, James E; Seiber, James N

    2015-11-01

    Sulfur has been widely used for centuries as a staple for pest and disease management in agriculture. Presently, it is the largest-volume pesticide in use worldwide. This review describes the sources and recovery methods for sulfur, its allotropic forms and properties and its agricultural uses, including development and potential advantages of nanosulfur as a fungicide. Chemical and microbial reactivity, interactions in soil and water and analytical methods for determination in environmental samples and foodstuffs, including inexpensive analytical methods for sulfur residues in wine, beer and other food/beverage substrates, will be reviewed. The toxicology of sulfur towards humans and agriculturally important fungi is included, with some restrictions on use to promote safety. The review concludes with areas for which more research is warranted. © 2015 Society of Chemical Industry.

  7. Decision analysis to complete diagnostic research by closing the gap between test characteristics and cost-effectiveness.

    Science.gov (United States)

    Schaafsma, Joanna D; van der Graaf, Yolanda; Rinkel, Gabriel J E; Buskens, Erik

    2009-12-01

    The lack of a standard methodology in diagnostic research impedes adequate evaluation before implementation of constantly developing diagnostic techniques. We discuss the methodology of diagnostic research and underscore the relevance of decision analysis in the process of evaluation of diagnostic tests. Overview and conceptual discussion. Diagnostic research requires a stepwise approach comprising assessment of test characteristics followed by evaluation of added value, clinical outcome, and cost-effectiveness. These multiple goals are generally incompatible with a randomized design. Decision-analytic models provide an important alternative through integration of the best available evidence. Thus, critical assessment of clinical value and efficient use of resources can be achieved. Decision-analytic models should be considered part of the standard methodology in diagnostic research. They can serve as a valid alternative to diagnostic randomized clinical trials (RCTs).

  8. Confronting Decision Cliffs: Diagnostic Assessment of Multi-Objective Evolutionary Algorithms' Performance for Addressing Uncertain Environmental Thresholds

    Science.gov (United States)

    Ward, V. L.; Singh, R.; Reed, P. M.; Keller, K.

    2014-12-01

    As water resources problems typically involve several stakeholders with conflicting objectives, multi-objective evolutionary algorithms (MOEAs) are now key tools for understanding management tradeoffs. Given the growing complexity of water planning problems, it is important to establish if an algorithm can consistently perform well on a given class of problems. This knowledge allows the decision analyst to focus on eliciting and evaluating appropriate problem formulations. This study proposes a multi-objective adaptation of the classic environmental economics "Lake Problem" as a computationally simple but mathematically challenging MOEA benchmarking problem. The lake problem abstracts a fictional town on a lake which hopes to maximize its economic benefit without degrading the lake's water quality to a eutrophic (polluted) state through excessive phosphorus loading. The problem poses the challenge of maintaining economic activity while confronting the uncertainty of potentially crossing a nonlinear and potentially irreversible pollution threshold beyond which the lake is eutrophic. Objectives for optimization are maximizing economic benefit from lake pollution, maximizing water quality, maximizing the reliability of remaining below the environmental threshold, and minimizing the probability that the town will have to drastically change pollution policies in any given year. The multi-objective formulation incorporates uncertainty with a stochastic phosphorus inflow abstracting non-point source pollution. We performed comprehensive diagnostics using 6 algorithms: Borg, MOEAD, eMOEA, eNSGAII, GDE3, and NSGAII to ascertain their controllability, reliability, efficiency, and effectiveness. The lake problem abstracts elements of many current water resources and climate related management applications where there is the potential for crossing irreversible, nonlinear thresholds. We show that many modern MOEAs can fail on this test problem, indicating its suitability as a

  9. Diagnostic value of adenosine deaminase in ascites for tuberculosis ascites: a meta-analysis.

    Science.gov (United States)

    Tao, Lin; Ning, Hong-Jian; Nie, Hai-Ming; Guo, Xiao-Yun; Qin, Shan-Yu; Jiang, Hai-Xing

    2014-05-01

    The diagnosis of tuberculosis (TB) ascites using standard diagnostic tools is difficult. The aim of the present meta-analysis was to establish the overall diagnostic accuracy of adenosine deaminase (ADA) levels in ascites for diagnosing TB ascites. A systematic review was performed of English language publications prior to April 2013. Sensitivity, specificity, and other measures of the accuracy of ADA for the diagnosis of TB ascites using ascites fluid were summarized using a random-effects model or a fixed-effects model. Receiver operating characteristic curves were used to summarize overall test performance. Seventeen studies involving 1797 subjects were eligible for the analysis. The summary estimates of sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, diagnostic odds ratio, and the area under cure of overall analysis were: 0.93, 0.94, 13.55, 0.11, 169.83, and 0.976, respectively; the results of sensitivity analysis of studies that used Giusti method were 0.94, 0.94, 12.99, 0.08, 183.18, and 0.977, respectively. Our results suggest that ADA in the ascites can be a sensitive and specific target and a critical criterion for the diagnosis of TB ascites. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Usage of Latent Class Analysis in Diagnostic Microbiology in the Absence of Gold Standard Test

    Directory of Open Access Journals (Sweden)

    Gul Bayram Abiha

    2016-12-01

    Full Text Available The evaluation of performance of various tests diagnostic tests in the absence of gold standard is an important problem. Latent class analysis (LCA is a statistical analysis method known for many years, especially in the absence of a gold standard for evaluation of diagnostic tests so that LCA has found its wide application area. During the last decade, LCA method has widely used in for determining sensivity and specifity of different microbiological tests. It has investigated in the diagnosis of mycobacterium tuberculosis, mycobacterium bovis, human papilloma virus, bordetella pertussis, influenza viruses, hepatitis E virus (HEV, hepatitis C virus (HCV and other various viral infections. Researchers have compared several diagnostic tests for the diagnosis of different pathogens with LCA. We aimed to evaluate performance of latent class analysis method used microbiological diagnosis in various diseases in several researches. When we took into account all of these tests' results, we suppose that LCA is a good statistical analysis method to assess different test performances in the absence of gold standard. [Archives Medical Review Journal 2016; 25(4.000: 467-488

  11. Environmental risk assessment in GMO analysis.

    Science.gov (United States)

    Pirondini, Andrea; Marmiroli, Nelson

    2010-01-01

    Genetically modified or engineered organisms (GMOs, GEOs) are utilised in agriculture, expressing traits of interest, such as insect or herbicide resistance. Soybean, maize, cotton and oilseed rape are the GM crops with the largest acreage in the world. The distribution of GM acreage in the different countries is related with the different positions concerning labelling of GMO products: based on the principle of substantial equivalence, or rather based on the precautionary principle. The paper provides an overview on how the risks associated with release of GMO in the environments can be analysed and predicted, in view of a possible coexistence of GM and non-GM organisms in agriculture.Risk assessment procedures, both qualitative and quantitative, are compared in the context of application to GMOs considering also legislation requirements (Directive 2001/18/EC). Criteria and measurable properties to assess harm for human health and environmental safety are listed, and the possible consequences are evaluated in terms of significance.Finally, a mapping of the possible risks deriving from GMO release is reported, focusing on gene transfer to related species, horizontal gene transfer, direct and indirect effects on non target organisms, development of resistance in target organisms, and effects on biodiversity.

  12. Development of environmental sample analysis techniques for safeguards

    International Nuclear Information System (INIS)

    Magara, Masaaki; Hanzawa, Yukiko; Esaka, Fumitaka

    1999-01-01

    JAERI has been developing environmental sample analysis techniques for safeguards and preparing a clean chemistry laboratory with clean rooms. Methods to be developed are a bulk analysis and a particle analysis. In the bulk analysis, Inductively-Coupled Plasma Mass Spectrometer or Thermal Ionization Mass Spectrometer are used to measure nuclear materials after chemical treatment of sample. In the particle analysis, Electron Probe Micro Analyzer and Secondary Ion Mass Spectrometer are used for elemental analysis and isotopic analysis, respectively. The design of the clean chemistry laboratory has been carried out and construction will be completed by the end of March, 2001. (author)

  13. Risk analysis within environmental impact assessment of proposed construction activity

    Energy Technology Data Exchange (ETDEWEB)

    Zeleňáková, Martina; Zvijáková, Lenka

    2017-01-15

    Environmental impact assessment is an important process, prior to approval of the investment plan, providing a detailed examination of the likely and foreseeable impacts of proposed construction activity on the environment. The objective of this paper is to develop a specific methodology for the analysis and evaluation of environmental impacts of selected constructions – flood protection structures using risk analysis methods. The application of methodology designed for the process of environmental impact assessment will develop assumptions for further improvements or more effective implementation and performance of this process. The main objective of the paper is to improve the implementation of the environmental impact assessment process. Through the use of risk analysis methods in environmental impact assessment process, the set objective has been achieved. - Highlights: This paper is informed by an effort to develop research with the aim of: • Improving existing qualitative and quantitative methods for assessing the impacts • A better understanding of relations between probabilities and consequences • Methodology for the EIA of flood protection constructions based on risk analysis • Creative approaches in the search for environmentally friendly proposed activities.

  14. Risk analysis within environmental impact assessment of proposed construction activity

    International Nuclear Information System (INIS)

    Zeleňáková, Martina; Zvijáková, Lenka

    2017-01-01

    Environmental impact assessment is an important process, prior to approval of the investment plan, providing a detailed examination of the likely and foreseeable impacts of proposed construction activity on the environment. The objective of this paper is to develop a specific methodology for the analysis and evaluation of environmental impacts of selected constructions – flood protection structures using risk analysis methods. The application of methodology designed for the process of environmental impact assessment will develop assumptions for further improvements or more effective implementation and performance of this process. The main objective of the paper is to improve the implementation of the environmental impact assessment process. Through the use of risk analysis methods in environmental impact assessment process, the set objective has been achieved. - Highlights: This paper is informed by an effort to develop research with the aim of: • Improving existing qualitative and quantitative methods for assessing the impacts • A better understanding of relations between probabilities and consequences • Methodology for the EIA of flood protection constructions based on risk analysis • Creative approaches in the search for environmentally friendly proposed activities.

  15. Error tolerance analysis of wave diagnostic based on coherent modulation imaging in high power laser system

    Science.gov (United States)

    Pan, Xingchen; Liu, Cheng; Zhu, Jianqiang

    2018-02-01

    Coherent modulation imaging providing fast convergence speed and high resolution with single diffraction pattern is a promising technique to satisfy the urgent demands for on-line multiple parameter diagnostics with single setup in high power laser facilities (HPLF). However, the influence of noise on the final calculated parameters concerned has not been investigated yet. According to a series of simulations with twenty different sampling beams generated based on the practical parameters and performance of HPLF, the quantitative analysis based on statistical results was first investigated after considering five different error sources. We found the background noise of detector and high quantization error will seriously affect the final accuracy and different parameters have different sensitivity to different noise sources. The simulation results and the corresponding analysis provide the potential directions to further improve the final accuracy of parameter diagnostics which is critically important to its formal applications in the daily routines of HPLF.

  16. Theoretical foundations for environmental Kuznets curve analysis

    Science.gov (United States)

    Lantz, Van

    This thesis provides a dynamic theory for analyzing the paths of aggregate output and pollution in a country over time. An infinite horizon, competitive growth-pollution model is explored in order to determine the role that economic scale, production techniques, and pollution regulations play in explaining the inverted U-shaped relationship between output and some forms of pollution (otherwise known as the Environmental Kuznets Curve, or EKC). Results indicate that the output-pollution relationship may follow a strictly increasing, strictly decreasing (but bounded), inverted U-shaped, or some combination of curves. While the 'scale' effect may cause output and pollution to exhibit a monotonic relationship, 'technique' and 'regulation' effects may ultimately cause a de-linking of these two variables. Pollution-minimizing energy regulation policies are also investigated within this framework. It is found that the EKC may be 'flattened' or even eliminated moving from a poorly-regulated economy to one that minimizes pollution. The model is calibrated to the US economy for output (gross national product, GNP) and two pollutants (sulfur dioxide, SO2, and carbon dioxide, CO2) over the period 1900 to 1990. Results indicate that the model replicates the observations quite well. The predominance of 'scale' effects cause aggregate SO2 and CO2 levels to increase with GNP in the early stages of development. Then, in the case of SO 2, 'technique' and 'regulation' effects may be the cause of falling SO2 levels with continued economic growth (establishing the EKC). CO2 continues to monotonically increase as output levels increase over time. The positive relationship may be due to the lack of regulations on this pollutant. If stricter regulation policies were instituted in the two case studies, an improved allocation of resources may result. While GNP may be 2.596 to 20% lower than what has been realized in the US economy (depending on the pollution variable analyzed), individual

  17. Urine microRNAs as biomarkers for bladder cancer: a diagnostic meta-analysis

    Directory of Open Access Journals (Sweden)

    Cheng Y

    2015-08-01

    Full Text Available Yidong Cheng,* Xiaheng Deng,* Xiao Yang,* Pengchao Li, Xiaolei Zhang, Peng Li, Jun Tao, Qiang Lu, Zengjun Wang Department of Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: The diagnostic value of microRNA (miRNA detection in patients with bladder cancer (BCa is controversial. We performed a diagnostic meta-analysis to evaluate current evidence on the use of miRNA assays to diagnose BCa. Methods: We systematically searched PubMed, Embase, and Web of Science for studies published before March 31, 2015. The pooled sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratio, and area under the curve (AUC were calculated to evaluate the overall test performance. Subgroup analyses were used to explore the between-study heterogeneity. Deeks’ funnel plot asymmetry test was used to test publication bias. We applied the software of RevMan 5.2 and Stata 11.0 to the meta-analysis. Results: A total of 23 studies from nine articles were included in the meta-analysis, with a total of 719 patients and 494 controls. The pooled sensitivity and specificity were 0.75 (95% confidence interval [CI], 0.68–0.80 and 0.75 (95% CI, 0.70–0.80, respectively. The pooled positive likelihood ratio was 3.03 (95% CI, 2.50–3.67; negative likelihood ratio was 0.33 (95% CI, 0.27–0.42; and diagnostic odds ratio was 9.07 (95% CI, 6.35–12.95. The pooled AUC was 0.81 (95% CI, 0.78–0.85. Subgroup analyses indicated that the multiple miRNAs assays and urine supernatant assays showed high accuracies in diagnosing BCa. Conclusion: The miRNA assays may serve as potential noninvasive diagnostic tool for the detection of BCa. However, the clinical application of miRNA assays for BCa diagnosis still needs further validation by large prospective studies. Keywords: microRNAs, bladder cancer, diagnostic accuracy, meta-analysis

  18. Thermodynamic analysis of environmental problems of energy

    Directory of Open Access Journals (Sweden)

    Kaganovich Boris M.

    2017-01-01

    Full Text Available The paper discusses the problems of the ecological analysis of physicochemical processes in power units and the impact of energy systems on the nature in large territorial regions. The model of extreme intermediate states developed at the Energy Systems Institute based on the principles of classical equilibrium thermodynamics was chosen to devise specific computational methods. The results of the conducted studies are presented and directions for further work are outlined.

  19. Application of the neutron activation analysis to environmental study

    International Nuclear Information System (INIS)

    Fu Bozhi.

    1995-01-01

    Neutron activation analysis is a nuclear analysis technology. It has been developed in recent times. By this means, the paper analyzes the element contents of leaves, soil and atmospheric dust-fall from the eastern and the western suburbs of Chengdu, then makes a comparison between the two areas and approaches some problems on environmental pollution

  20. Environmental system analysis of tomato production in Ghana ...

    African Journals Online (AJOL)

    The aim of this study was to identify the most important sources of greenhouse gases, acidifying and eutrophying compounds associated with tomato production in Ghana and identify options to reduce the environmental impacts. Life Cycle Analysis (LCA) methodology was used in the analysis (Cradle to gate approach).

  1. Serum Immunoglobulin G4 in Discriminating Autoimmune Pancreatitis From Pancreatic Cancer: A Diagnostic Meta-analysis.

    Science.gov (United States)

    Dai, Cong; Cao, Qin; Jiang, Min; Sun, Ming-Jun

    2018-03-01

    Differentiation between autoimmune pancreatitis (AIP) and pancreatic cancer (PC) is a clinical challenge. Emerging published data on the accuracy of serum immunoglobulin G4 (IgG4) for the differential diagnosis between AIP and PC are inconsistent. The objective of our study was to perform a meta-analysis evaluating the clinical utility of serum IgG4 in the differential diagnosis between AIP and PC. We performed a systematic literature search of multiple electronic databases. The methodological quality of each study was assessed according to the Quality Assessment of Diagnostic Accuracy Studies checklist. Random-effects model was used to summarize the diagnostic odds ratio and other measures of accuracy. Eleven studies comprising 523 AIP patients and 771 PC patients were included in the meta-analysis. The summary estimates for serum IgG4 in distinguishing AIP from PC were as follows: diagnostic odds ratio, 57.30 (95% confidence interval [CI], 23.17-141.67); sensitivity, 0.72 (95% CI, 0.68-0.76); specificity, 0.93 (95% CI, 0.91-0.94). The area under the curve of serum IgG4 in distinguishing AIP from PC was 0.9200. Our meta-analysis found that serum IgG4 has high specificity and relatively low sensitivity in the differential diagnosis between AIP and PC. Therefore, serum IgG4 is useful in distinguishing AIP from PC.

  2. LOGICAL CONDITIONS ANALYSIS METHOD FOR DIAGNOSTIC TEST RESULTS DECODING APPLIED TO COMPETENCE ELEMENTS PROFICIENCY

    Directory of Open Access Journals (Sweden)

    V. I. Freyman

    2015-11-01

    Full Text Available Subject of Research.Representation features of education results for competence-based educational programs are analyzed. Solution importance of decoding and proficiency estimation for elements and components of discipline parts of competences is shown. The purpose and objectives of research are formulated. Methods. The paper deals with methods of mathematical logic, Boolean algebra, and parametrical analysis of complex diagnostic test results, that controls proficiency of some discipline competence elements. Results. The method of logical conditions analysis is created. It will give the possibility to formulate logical conditions for proficiency determination of each discipline competence element, controlled by complex diagnostic test. Normalized test result is divided into noncrossing zones; a logical condition about controlled elements proficiency is formulated for each of them. Summarized characteristics for test result zones are imposed. An example of logical conditions forming for diagnostic test with preset features is provided. Practical Relevance. The proposed method of logical conditions analysis is applied in the decoding algorithm of proficiency test diagnosis for discipline competence elements. It will give the possibility to automate the search procedure for elements with insufficient proficiency, and is also usable for estimation of education results of a discipline or a component of competence-based educational program.

  3. Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis

    Directory of Open Access Journals (Sweden)

    Joshua D Webster

    2012-01-01

    Full Text Available The extent to which histopathology pattern recognition image analysis (PRIA agrees with microscopic assessment has not been established. Thus, a commercial PRIA platform was evaluated in two applications using whole-slide images. Substantial agreement, lacking significant constant or proportional errors, between PRIA and manual morphometric image segmentation was obtained for pulmonary metastatic cancer areas (Passing/Bablok regression. Bland-Altman analysis indicated heteroscedastic measurements and tendency toward increasing variance with increasing tumor burden, but no significant trend in mean bias. The average between-methods percent tumor content difference was -0.64. Analysis of between-methods measurement differences relative to the percent tumor magnitude revealed that method disagreement had an impact primarily in the smallest measurements (tumor burden 0.988, indicating high reproducibility for both methods, yet PRIA reproducibility was superior (C.V.: PRIA = 7.4, manual = 17.1. Evaluation of PRIA on morphologically complex teratomas led to diagnostic agreement with pathologist assessments of pluripotency on subsets of teratomas. Accommodation of the diversity of teratoma histologic features frequently resulted in detrimental trade-offs, increasing PRIA error elsewhere in images. PRIA error was nonrandom and influenced by variations in histomorphology. File-size limitations encountered while training algorithms and consequences of spectral image processing dominance contributed to diagnostic inaccuracies experienced for some teratomas. PRIA appeared better suited for tissues with limited phenotypic diversity. Technical improvements may enhance diagnostic agreement, and consistent pathologist input will benefit further development and application of PRIA.

  4. Investigation into diagnostic agreement using automated computer-assisted histopathology pattern recognition image analysis.

    Science.gov (United States)

    Webster, Joshua D; Michalowski, Aleksandra M; Dwyer, Jennifer E; Corps, Kara N; Wei, Bih-Rong; Juopperi, Tarja; Hoover, Shelley B; Simpson, R Mark

    2012-01-01

    The extent to which histopathology pattern recognition image analysis (PRIA) agrees with microscopic assessment has not been established. Thus, a commercial PRIA platform was evaluated in two applications using whole-slide images. Substantial agreement, lacking significant constant or proportional errors, between PRIA and manual morphometric image segmentation was obtained for pulmonary metastatic cancer areas (Passing/Bablok regression). Bland-Altman analysis indicated heteroscedastic measurements and tendency toward increasing variance with increasing tumor burden, but no significant trend in mean bias. The average between-methods percent tumor content difference was -0.64. Analysis of between-methods measurement differences relative to the percent tumor magnitude revealed that method disagreement had an impact primarily in the smallest measurements (tumor burden 0.988, indicating high reproducibility for both methods, yet PRIA reproducibility was superior (C.V.: PRIA = 7.4, manual = 17.1). Evaluation of PRIA on morphologically complex teratomas led to diagnostic agreement with pathologist assessments of pluripotency on subsets of teratomas. Accommodation of the diversity of teratoma histologic features frequently resulted in detrimental trade-offs, increasing PRIA error elsewhere in images. PRIA error was nonrandom and influenced by variations in histomorphology. File-size limitations encountered while training algorithms and consequences of spectral image processing dominance contributed to diagnostic inaccuracies experienced for some teratomas. PRIA appeared better suited for tissues with limited phenotypic diversity. Technical improvements may enhance diagnostic agreement, and consistent pathologist input will benefit further development and application of PRIA.

  5. Nontargeted diagnostic ion network analysis (NINA): A software to streamline the analytical workflow for untargeted characterization of natural medicines.

    Science.gov (United States)

    Ye, Hui; Zhu, Lin; Sun, Di; Luo, Xiaozhuo; Lu, Gaoyuan; Wang, Hong; Wang, Jing; Cao, Guoxiu; Xiao, Wei; Wang, Zhenzhong; Wang, Guangji; Hao, Haiping

    2016-11-30

    The characterization of herbal prescriptions serves as a foundation for quality control and regulation of herbal medicines. Previously, the characterization of herbal chemicals from natural medicines often relied on the analysis of signature fragment ions from the acquired tandem mass spectrometry (MS/MS) spectra with prior knowledge of the herbal species present in the herbal prescriptions of interest. Nevertheless, such an approach is often limited to target components, and it risks missing the critical components that we have no prior knowledge of. We previously reported a "diagnostic ion-guided network bridging" strategy. It is a generally applicable and robust approach to analyze unknown substances from complex mixtures in an untargeted manner. In this study, we have developed a standalone software named "Nontargeted Diagnostic Ion Network Analysis (NINA)" with a graphical user interface based on a strategy for post-acquisition data analysis. NINA allows one to rapidly determine the nontargeted diagnostic ions (NIs) by summarizing all of the fragment ions shared by the precursors from the acquired MS/MS spectra. A NI-guided network using bridging components that possess two or more NIs can then be established via NINA. With such a network, we could sequentially identify the structures of all the NIs once a single compound has been identified de novo. The structures of NIs can then be used as "priori" knowledge to narrow the candidates containing the sub-structure of the corresponding NI from the database hits. Subsequently, we applied the NINA software to the characterization of a model herbal prescription, Re-Du-Ning injection, and rapidly identified 56 herbal chemicals from the prescription using an ultra-performance liquid chromatography quadrupole time-of-flight system in the negative mode with no knowledge of the herbal species or herbal chemicals in the mixture. Therefore, we believe the applications of NINA will greatly facilitate the characterization

  6. Environmental risk analysis for nanomaterials: Review and evaluation of frameworks

    DEFF Research Database (Denmark)

    Grieger, Khara Deanne; Linkov, Igor; Hansen, Steffen Foss

    2012-01-01

    to occupational settings with minor environmental considerations, and most have not been thoroughly tested on a wide range of NM. Care should also be taken when selecting the most appropriate risk analysis strategy for a given risk context. Given this, we recommend a multi-faceted approach to assess...... the environmental risks of NM as well as increased applications and testing of the proposed frameworks for different NM....

  7. Towards a more efficient environmental policy. A socio-economic analysis of four persistent environmental problems

    International Nuclear Information System (INIS)

    2000-11-01

    For the benefit of the National Environmental Policy Plan that will be published in 2001, the Netherlands Bureau for Economic Policy Analysis analysed four persistent environmental problems. These problems are the environmental effects of the manure surplus in the agricultural sector; the climate problem; the acidification by traffic and the air traffic noise around the airport Schiphol. This study not only looks ahead, but also looks back on 30 years of environmental policy. From a welfare economic perspective an analysis is made of the efficiency and effectiveness of that policy. Several questions are answered,e.g.: how could the manure problem of such a small sector as the livestock breeding persist for so many years?; how effective were the agreements with the industry and other sectors on energy efficiency improvement?; what made the acidification policy directed on traffic so successful?; why is the noise production of air traffic still a problem whereas the number of seriously bothered houses is decreased? The answers on these questions provide information which can be useful for the formulation of the future environmental policy. This information refers to the conditions for formulating adequate policy goals, the relation between those goals and policy instruments and the differences between direct versus indirect steering. This report also gives some points of interest for tackling complex international environmental problems. refs

  8. Organically bound tritium analysis in environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Baglan, N. [CEA/DAM/DIF, Arpajon (France); Kim, S.B. [AECL, Chalk River Laboratories, Chalk River, ON (Canada); Cossonnet, C. [IRSN/PRP-ENV/STEME/LMRE, Orsay (France); Croudace, I.W.; Warwick, P.E. [GAU-Radioanalytical, University of Southampton, Southampton (United Kingdom); Fournier, M. [IRSN/DG/DMQ, Fontenay-aux-Roses (France); Galeriu, D. [IFIN-HH, Horia-Hulubei, Inst. Phys. and Nucl. Eng., Bucharest (Romania); Momoshima, N. [Kyushu University, Radioisotope Ctr., Fukuoka (Japan); Ansoborlo, E. [CEA/DEN/DRCP/CETAMA, Bagnols-sur-Ceze (France)

    2015-03-15

    Organically bound tritium (OBT) has become of increased interest within the last decade, with a focus on its behaviour and also its analysis, which are important to assess tritium distribution in the environment. In contrast, there are no certified reference materials and no standard analytical method through the international organization related to OBT. In order to resolve this issue, an OBT international working group was created in May 2012. Over 20 labs from around the world participated and submitted their results for the first intercomparison exercise results on potato (Sep 2013). The samples, specially-prepared potatoes, were provided in March 2013 to each participant. Technical information and results from this first exercise are discussed here for all the labs which have realised the five replicates necessary to allow a reliable statistical treatment. The results are encouraging as the increased number of participating labs did not degrade the observed dispersion of the results for a similar activity level. Therefore, the results do not seem to depend on the analytical procedure used. From this work an optimised procedure can start to be developed to deal with OBT analysis and will guide subsequent planned OBT trials by the international group.

  9. Real-time measurement and control at JET signal processing and physics analysis for diagnostics

    International Nuclear Information System (INIS)

    Felton, R.; Joffrin, E.; Murari, A.

    2005-01-01

    To meet the requirements of the scientific programme, the EFDA JET real-time measurement and control project has developed an integrated set of real-time plasma measurements, experiment control and communication facilities. Traditional experiments collected instrument data during the plasma pulse and calculated physics data after the pulse. The challenge for continuous tokamak operation is to calculate the physics data in real-time, keeping up with the evolution of the plasma. In JET, many plasma diagnostics have been augmented with extra data acquisition and signal-processing systems so that they can both capture instrument data for conventional post-pulse analysis and calculate calibrated, validated physics results in real-time. During the pulse, the systems send sampled data sets into a network, which distributes the data to several destinations. The receiving systems may do further analysis, integrating data from several measurements, or may control the plasma scenario by heating or fuelling. The simplest real-time diagnostic systems apply scale factors to the signals, as with the electron cyclotron emission (ECE) diagnostic's 96 tuned radiometer channels, giving the electron temperature profile. In various spectroscopy diagnostics, spectral features are least-squares-fitted to measure spectra from several lines of sight, within 50 ms. Ion temperatures and rotation speed can be calculated from the line widths and shifts. For diagnostics using modulation techniques, the systems implement digital-signal processing phase trackers, lock-in amplifiers and filters, e.g., the far infrared (FIR) interferometer samples 15 channels at 400 kHz for 30 s, i.e., six million samples per second. Diagnostics have specific lines of sight, spatial channels, and various sampling rates. The heating/fuelling systems have relatively coarse spatial localisation. Analysis systems have been developed to integrate the basic physics data into smaller sets of controllable parameters on a

  10. Golgi protein 73 as a biomarker for hepatocellular carcinoma: A diagnostic meta-analysis.

    Science.gov (United States)

    Yang, Jing; Li, Jingjing; Dai, Weiqi; Wang, Fan; Shen, Miao; Chen, Kan; Cheng, Ping; Zhang, Yan; Wang, Chengfen; Zhu, Rong; Zhang, Huawei; Zheng, Yuanyuan; Wang, Junshan; Xia, Yujing; Lu, Jie; Zhou, Yingqun; Guo, Chuanyong

    2015-04-01

    Hepatocellular carcinoma (HCC) is the most common primary malignancy of the liver and the third leading cause of cancer-related mortality worldwide. Conflicting results have been reported regarding the use of serum Golgi protein 73 (GP73) as a promising serum marker for the diagnosis of HCC; therefore, the aim of the present study was to provide a systematic review of the diagnostic performance of GP73 for HCC. Following a systematic review of the relevant studies, a number of indices associated with the accuracy of the diagnostic performance of GP73, including the sensitivity and specificity, were pooled using Meta Disc 1.4 software. Data were presented as forest plots, and summary receiver operating characteristic (SROC) curve analysis was used to summarize the overall test performance. Eleven studies were included in this meta-analysis. The summary estimates for serum GP73 in diagnosing HCC were as follows: Sensitivity, 77% [95% confidence interval (CI), 75-79%]; specificity, 91% (95% CI, 90-92%); positive likelihood ratio, 4.34 (95% CI, 2.19-8.59); negative likelihood ratio, 0.30 (95% CI, 0.26-0.36) and diagnostic odds ratio, 15.78 (95% CI, 6.95-35.83). The area under the SROC curve was 0.8638, and the Q index was 0.7944. Significant heterogeneity was found. This meta-analysis indicates a moderate diagnostic value of GP73 in HCC; however, further studies with rigorous design, large sample size and multiregional cooperation are required.

  11. Field Raman spectrograph for environmental analysis

    International Nuclear Information System (INIS)

    Haas, J.W. III; Forney, R.W.; Carrabba, M.M.; Rauh, R.D.

    1995-01-01

    The enormous cost for chemical analysis at DOE facilities predicates that cost-saving measures be implemented. Many approaches, ranging from increasing laboratory sample throughput by reducing preparation time to the development of field instrumentation, are being explored to meet this need. Because of the presence of radioactive materials at many DOE sites, there is also a need for methods that are safer for site personnel and analysts. This project entails the development of a compact Raman spectrograph for field screening and monitoring of a wide variety of wastes, pollutants, and corrosion products in storage tanks, soils, and ground and surface waters. Analytical advantages of the Raman technique include its ability to produce a unique, spectral fingerprint for each contaminant and its ability to analyze both solids and liquids directly, without the need for isolation or cleanup

  12. Diagnostic indicators of non-cardiovascular chest pain: a systematic review and meta-analysis

    Science.gov (United States)

    2013-01-01

    Background Non-cardiovascular chest pain (NCCP) has a high healthcare cost, but insufficient guidelines exist for its diagnostic investigation. The objective of the present work was to identify important diagnostic indicators and their accuracy for specific and non-specific conditions underlying NCCP. Methods A systematic review and meta-analysis were performed. In May 2012, six databases were searched. Hand and bibliography searches were also conducted. Studies evaluating a diagnostic test against a reference test in patients with NCCP were included. Exclusion criteria were having diagnostic tests for acute cardiovascular disease. Diagnostic accuracy is given in likelihood ratios (LR): very good (LR+ >10, LR- diagnostic test sensitivity and specificity was performed by applying a hierarchical Bayesian model. Results Out of 6,316 records, 260 were reviewed in full text, and 28 were included: 20 investigating gastroesophageal reflux disorders (GERD), 3 musculoskeletal chest pain, and 5 psychiatric conditions. Study quality was good in 15 studies and moderate in 13. GERD diagnosis was more likely with typical GERD symptoms (LR + 2.70 and 2.75, LR- 0.42 and 0.78) than atypical GERD symptoms (LR + 0.49, LR- 2.71). GERD was also more likely with a positive response to a proton pump inhibitor (PPI) test (LR + 5.48, 7.13, and 8.56; LR- 0.24, 0.25, and 0.28); the posterior mean sensitivity and specificity of six studies were 0.89 (95% credible interval, 0.28 to 1) and 0.88 (95% credible interval, 0.26 to 1), respectively. Panic and anxiety screening scores can identify individuals requiring further testing for anxiety or panic disorders. Clinical findings in musculoskeletal pain either had a fair to moderate LR + and a poor LR- or vice versa. Conclusions In patients with NCCP, thorough clinical evaluation of the patient’s history, symptoms, and clinical findings can indicate the most appropriate diagnostic tests. Treatment response to high-dose PPI

  13. Data management and statistical analysis for environmental assessment

    International Nuclear Information System (INIS)

    Wendelberger, J.R.; McVittie, T.I.

    1995-01-01

    Data management and statistical analysis for environmental assessment are important issues on the interface of computer science and statistics. Data collection for environmental decision making can generate large quantities of various types of data. A database/GIS system developed is described which provides efficient data storage as well as visualization tools which may be integrated into the data analysis process. FIMAD is a living database and GIS system. The system has changed and developed over time to meet the needs of the Los Alamos National Laboratory Restoration Program. The system provides a repository for data which may be accessed by different individuals for different purposes. The database structure is driven by the large amount and varied types of data required for environmental assessment. The integration of the database with the GIS system provides the foundation for powerful visualization and analysis capabilities

  14. Field Raman Spectrograph for Environmental Analysis

    International Nuclear Information System (INIS)

    Sylvia, J.M.; Haas, J.W.; Spencer, K.M.; Carrabba, M.M.; Rauh, R.D.; Forney, R.W.; Johnston, T.M.

    1998-01-01

    The widespread contamination found across the US Department of Energy (DOE) complex has received considerable attention from the government and public alike. A massive site characterization and cleanup effort has been underway for several years and is expected to continue for several decades more. The scope of the cleanup effort ranges from soil excavation and treatment to complete dismantling and decontamination of whole buildings. To its credit, DOE has supported research and development of new technologies to speed up and reduce the cost of this effort. One area in particular has been the development of portable instrumentation that can be used to perform analytical measurements in the field. This approach provides timely data to decision makers and eliminates the expense, delays, and uncertainties of sample preservation, transport, storage, and laboratory analysis. In this program, we have developed and demonstrated in the field a transportable, high performance Raman spectrograph that can be used to detect and identify contaminants in a variety of scenarios. With no moving parts, the spectrograph is rugged and can perform many Raman measurements in situ with flexible fiber optic sampling probes. The instrument operates under computer control and a software package has been developed to collect and process spectral data. A collection of Raman spectra for 200 contaminants of DOE importance has been compiled in a searchable format to assist in the identification of unknown contaminants in the field

  15. Analysis of mercury in environmental samples

    International Nuclear Information System (INIS)

    Schoester, F.S.

    1992-01-01

    The possibility to determine mercury in sub-ppm levels in biological samples has been studied through neutron activation analysis , using as standards aliquots of mercury nitrate solution, deposited on treated cellulose with thio acetamide and ammonia. Sample and standards were irradiated simultaneously in quartz ampoules during 8 hours at a flux of 5 x 10 13 n/cm 2 s and were counted in a hyper pure germanium detector after 4 weeks of decay. Corrections were made for the interference of 75 Se in the 279 keV photopeak used in the determination. The results obtained for the reference materials IAEA-H-8(horse kidney), IAEA-M A-A2(fish flesh) and IAEA-M A-A-1(cope pod homogenate) were (0.91±0.07), (0.56±0.02) and (0.17±0.02) ppm, versus certified values of (0.91±0.08), (0.47±0.02) and (0.28±0.01) ppm respectively. (EMR). 54 refs., 8 app

  16. Limited diagnostic value of enzyme analysis in patients with mitochondrial tRNA mutations

    DEFF Research Database (Denmark)

    Wibrand, Flemming; Jeppesen, Tina Dysgaard; Frederiksen, Anja L

    2010-01-01

    We evaluated the diagnostic value of respiratory chain (RC) enzyme analysis of muscle in adult patients with mitochondrial myopathy (MM). RC enzyme activity was measured in muscle biopsies from 39 patients who carry either the 3243A>G mutation, other tRNA point mutations, or single, large......, respectively, in these three groups. The results indicate that RC enzyme analysis in muscle is not a sensitive test for MM in adults. In these patients, abnormal muscle histochemistry appears to be a better predictor ofMM....

  17. Diagnostic and therapeutic implications of genetic heterogeneity in myeloid neoplasms uncovered by comprehensive mutational analysis

    Directory of Open Access Journals (Sweden)

    Sarah M. Choi

    2017-01-01

    Full Text Available While growing use of comprehensive mutational analysis has led to the discovery of innumerable genetic alterations associated with various myeloid neoplasms, the under-recognized phenomenon of genetic heterogeneity within such neoplasms creates a potential for diagnostic confusion. Here, we describe two cases where expanded mutational testing led to amendment of an initial diagnosis of chronic myelogenous leukemia with subsequent altered treatment of each patient. We demonstrate the power of comprehensive testing in ensuring appropriate classification of genetically heterogeneous neoplasms, and emphasize thoughtful analysis of molecular and genetic data as an essential component of diagnosis and management.

  18. On-line diagnostic techniques for air-operated control valves based on time series analysis

    International Nuclear Information System (INIS)

    Ito, Kenji; Matsuoka, Yoshinori; Minamikawa, Shigeru; Komatsu, Yasuki; Satoh, Takeshi.

    1996-01-01

    The objective of this research is to study the feasibility of applying on-line diagnostic techniques based on time series analysis to air-operated control valves - numerous valves of the type which are used in PWR plants. Generally the techniques can detect anomalies by failures in the initial stages for which detection is difficult by conventional surveillance of process parameters measured directly. However, the effectiveness of these techniques depends on the system being diagnosed. The difficulties in applying diagnostic techniques to air-operated control valves seem to come from the reduced sensitivity of their response as compared with hydraulic control systems, as well as the need to identify anomalies in low level signals that fluctuate only slightly but continuously. In this research, simulation tests were performed by setting various kinds of failure modes for a test valve with the same specifications as of a valve actually used in the plants. Actual control signals recorded from an operating plant were then used as input signals for simulation. The results of the tests confirmed the feasibility of applying on-line diagnostic techniques based on time series analysis to air-operated control valves. (author)

  19. A potential new diagnostic tool to aid DNA analysis from heat compromised bone using colorimetry: A preliminary study.

    Science.gov (United States)

    Fredericks, Jamie D; Ringrose, Trevor J; Dicken, Anthony; Williams, Anna; Bennett, Phil

    2015-03-01

    Extracting viable DNA from many forensic sample types can be very challenging, as environmental conditions may be far from optimal with regard to DNA preservation. Consequently, skeletal tissue can often be an invaluable source of DNA. The bone matrix provides a hardened material that encapsulates DNA, acting as a barrier to environmental insults that would otherwise be detrimental to its integrity. However, like all forensic samples, DNA in bone can still become degraded in extreme conditions, such as intense heat. Extracting DNA from bone can be laborious and time-consuming. Thus, a lot of time and money can be wasted processing samples that do not ultimately yield viable DNA. We describe the use of colorimetry as a novel diagnostic tool that can assist DNA analysis from heat-treated bone. This study focuses on characterizing changes in the material and physical properties of heated bone, and their correlation with digitally measured color variation. The results demonstrate that the color of bone, which serves as an indicator of the chemical processes that have occurred, can be correlated with the success or failure of subsequent DNA amplification. Copyright © 2014 Forensic Science Society. Published by Elsevier Ireland Ltd. All rights reserved.

  20. A Review of Frequency Response Analysis Methods for Power Transformer Diagnostics

    Directory of Open Access Journals (Sweden)

    Saleh Alsuhaibani

    2016-10-01

    Full Text Available Power transformers play a critical role in electric power networks. Such transformers can suffer failures due to multiple stresses and aging. Thus, assessment of condition and diagnostic techniques are of great importance for improving power network reliability and service continuity. Several techniques are available to diagnose the faults within the power transformer. Frequency response analysis (FRA method is a powerful technique for diagnosing transformer winding deformation and several other types of problems that are caused during manufacture, transportation, installation and/or service life. This paper provides a comprehensive review on FRA methods and their applications in diagnostics and fault identification for power transformers. The paper discusses theory and applications of FRA methods as well as various issues and challenges faced in the application of this method.

  1. Environmental mining plan of the construction materials industry in Cartagena, Phase 1 Diagnostic. Vol.1 and Vol.2(Annex)

    International Nuclear Information System (INIS)

    Castiblanco, Carmen Rosa; Franco Serna, Jose Vicente; Nino, Jaime

    1996-01-01

    INGEOMINAS carried out this project in the cities of Cartagena, Bucaramanga, Cali and Bogota, in two phases: Phase 1 (Diagnostic) and Phase II (Formulation of Handling Plan). The phase 1 that here is described, it upgrades the knowledge of the extractive industry of the construction materials for the city of Cartagena, through bibliographical revision and field work, carried out in 50 quarries that supply from these materials to the city. This study, besides the economic and legal handling, identifies technical aspects related with the geology, the mining and the environmental situation. In accordance with their likeness, geologic, morphological and of exploitation (extraction methods and mining development), the quarries met in five groups: Exploitations on calcareous deposits of the La Popa Formation, exploitations on clay deposits of the La Popa Formation, exploitations on detritus deposits of half grain to thick (La Popa-Arenosa Formation; Pendales Conglomerate and Rotinet Formation) and exploitation of calcareous of the Arroyo de Piedra Formation. The extraction of these materials is characterized by its low degree of development technician, lack of planning mining, lack of appropriate infrastructure that allows a better development of the sector, is also evident the control lack on the part of the entities in charge of the handling of this industry. These factors added to a demand every time in increase of these materials, they have taken to a progressive deterioration in the landscape, increase of the noise and particles in the air and in the waters. The low control in this activity has generated the proliferation of informal exploitations that they find in this activity a way of subsistence

  2. Ash contents of foodstuff samples in environmental radioactivity analysis

    International Nuclear Information System (INIS)

    Oikawa, Shinji; Ohta, Hiroshi; Hayano, Kazuhiko; Nonaka, Nobuhiro

    2004-01-01

    Statistical data of the ash content in various environmental samples obtained from an environmental radioactivity survey project commissioned by the Japanese government of Science and Technology Agency (at present Ministry of Education, Culture, Sports, Sciences and Technology) during the past 10 years are expressed for establishing a standard of ash content in environmental samples based on radioactivity analysis. The ash content for some kinds of environmental samples such as dietary food, milk, Japanese radish, spinach, fish, green tea and potato was reviewed in the light of statistical and stochastic viewpoints. For all of the samples reviewed in this paper, the coefficient of variation varied from 4.7% for milk to 36.3% for cabbage. Dietary food and milk samples were reviewed more than 1900 and 1400 samples, respectively. Especially, ash content of dietary food depended mainly on the dietary culture reflected on the period. However it showed an almost invariant distribution within 18.7% of coefficient of variation during the past 10 years. Pretreatment of environmental samples especially ashing processes are important from the viewpoint on environmental radioactivity analysis, which is one of the especial fields in analytical chemistry. Statistical reviewed data obtained in this paper may be useful for sample preparation. (author)

  3. Analysis Tools for the Ion Cyclotron Emission Diagnostic on DIII-D

    Science.gov (United States)

    Del Castillo, C. A.; Thome, K. E.; Pinsker, R. I.; Meneghini, O.; Pace, D. C.

    2017-10-01

    Ion cyclotron emission (ICE) waves are excited by suprathermal particles such as neutral beam particles and fusion products. An ICE diagnostic is in consideration for use at ITER, where it could provide important passive measurement of fast ions location and losses, which are otherwise difficult to determine. Simple ICE data analysis codes had previously been developed, but more sophisticated codes are required to facilitate data analysis. Several terabytes of ICE data were collected on DIII-D during the 2015-2017 campaign. The ICE diagnostic consists of antenna straps and dedicated magnetic probes that are both digitized at 200 MHz. A suite of Python spectral analysis tools within the OMFIT framework is under development to perform the memory-intensive analysis of this data. A fast and optimized analysis allows ready access to data visualizations as spectrograms and as plots of both frequency and time cuts of the data. A database of processed ICE data is being constructed to understand the relationship between the frequency and intensity of ICE and a variety of experimental parameters including neutral beam power and geometry, local and global plasma parameters, magnetic fields, and many others. Work supported in part by US DoE under the Science Undergraduate Laboratory Internship (SULI) program and under DE-FC02-04ER54698.

  4. A Sensitivity Analysis Approach to Identify Key Environmental Performance Factors

    Directory of Open Access Journals (Sweden)

    Xi Yu

    2014-01-01

    Full Text Available Life cycle assessment (LCA is widely used in design phase to reduce the product’s environmental impacts through the whole product life cycle (PLC during the last two decades. The traditional LCA is restricted to assessing the environmental impacts of a product and the results cannot reflect the effects of changes within the life cycle. In order to improve the quality of ecodesign, it is a growing need to develop an approach which can reflect the changes between the design parameters and product’s environmental impacts. A sensitivity analysis approach based on LCA and ecodesign is proposed in this paper. The key environmental performance factors which have significant influence on the products’ environmental impacts can be identified by analyzing the relationship between environmental impacts and the design parameters. Users without much environmental knowledge can use this approach to determine which design parameter should be first considered when (redesigning a product. A printed circuit board (PCB case study is conducted; eight design parameters are chosen to be analyzed by our approach. The result shows that the carbon dioxide emission during the PCB manufacture is highly sensitive to the area of PCB panel.

  5. New trends in sample preparation techniques for environmental analysis.

    Science.gov (United States)

    Ribeiro, Cláudia; Ribeiro, Ana Rita; Maia, Alexandra S; Gonçalves, Virgínia M F; Tiritan, Maria Elizabeth

    2014-01-01

    Environmental samples include a wide variety of complex matrices, with low concentrations of analytes and presence of several interferences. Sample preparation is a critical step and the main source of uncertainties in the analysis of environmental samples, and it is usually laborious, high cost, time consuming, and polluting. In this context, there is increasing interest in developing faster, cost-effective, and environmentally friendly sample preparation techniques. Recently, new methods have been developed and optimized in order to miniaturize extraction steps, to reduce solvent consumption or become solventless, and to automate systems. This review attempts to present an overview of the fundamentals, procedure, and application of the most recently developed sample preparation techniques for the extraction, cleanup, and concentration of organic pollutants from environmental samples. These techniques include: solid phase microextraction, on-line solid phase extraction, microextraction by packed sorbent, dispersive liquid-liquid microextraction, and QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe).

  6. Analysis of the environmental impact generated by nuclear activities

    International Nuclear Information System (INIS)

    Lazar, Roxana Elena; Dumitrescu, Maria

    2000-01-01

    Assessment of environmental impact represents one of the most formalized examples of interdisciplinary approach. After more then a century from the introduction of the concept of environmental impact assessment, this undertaking still represents an amalgamation of mini-studies based on pre-determined approaches rather than a genuine integrated document. This work presents the most important and adequate techniques of analysis of environmental impact generated by nuclear activities starting from identification of the events causing negative effects upon environment (by using checking list, the matrices and the cause-effect diagram) and radiation dose determination up to the decision making process. To preserve environment integrity the human factor should be re-evaluated as well as its active participation in formation and settling of an real environmental culture

  7. American and Canadian environmental federalism: A game-theoretic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Gillroy, J.M.

    1999-07-01

    To understand why environmental federalism is different in Canada and the United States, one might begin with the initial strategic realities that faced the Fathers of Canadian Confederation and the Framers of the Constitution of the US. This essay examined federalism from a game theoretic point of view, to integrate and expose the rational properties of the decision to federate and the logical entailments of that choice for environmental policy within two specific strategic contexts. Specifically, the author suggests that American environmental federalism has arisen in response to the strategic reality of a prisoner's dilemma, while Canadian environmental federalism can be analyzed as an effort to regulate confrontations within a game of chicken. In addition to the analysis of each federated structure, evidence from five case studies demonstrates the usefulness of games to the study of comparative federalism.

  8. Environmental pressures from European consumption and production. A study in integrated environmental and economic analysis

    Energy Technology Data Exchange (ETDEWEB)

    Watson, D. [Copenhagen Resource Institute, Copenhagen (Denmark); Fernandez, J.A.; Wittmer, D. [Wuppertal Institute, Wuppertal (Germany); Gravgaerd Pedersen, O. [Statistics Denmark, Copenhagen (Denmark); European Topic Centre on Sustainable Consumption and Production, Copenhagen (Denmark)

    2013-03-15

    Environmental pressures from European consumption and production shows how economic and environmental data can be integrated to analyse environmental performance and material efficiency of whole economies as well as their individual elements. The analyses presented in the report provide policy makers with a tool to target economic incentives and information campaigns, encouraging a shift to more sustainable production and consumption patterns in order to reduce Europe's global footprint. The report discusses two analytical approaches. The production-based method considers direct environmental pressures caused by European industries and service providers - for example, the extraction of material resources by the mining and quarrying sector, air pollutants from power stations, greenhouse gas emissions from agriculture and so on. The consumption-based method focuses on the indirect environmental pressures caused by European consumers. In this approach, the direct production-related pressures are attributed to broad groups of products and services, also taking into account pressures that are embodied in goods imported into the EU. Using Environmentally Extended Input Output Analysis (EE-IOA) it is possible to estimate the environmental pressures ultimately generated by individual product groups and also by European consumption as a whole. Four types of environmental pressures are considered by the report: raw material use, greenhouse gas emissions, acidifying air emissions, and air pollutants leading to harmful ground-level ozone. However, the method has the potential to assess many other types of environmental pressure including land use, water use, waste generation and energy use. Thanks to the conceptual consistency between the system of national economic accounts and environmental accounts, data on environmental pressures is directly comparable to economic expenditure. Policy makers can thus see which sectors have been most successful in decoupling

  9. WATERSHED SELECTION FOR ENVIRONMENTAL REHABILITATION USING MULTICRITERIA ANALYSIS

    Directory of Open Access Journals (Sweden)

    Carlos Eduardo da Silva Francisco

    2009-10-01

    Full Text Available The Anhumas creek watershed, in the region of Campinas, São Paulo State, Brazil, is degraded also as a result of unplanned land use of its riparian zones, considered Permanent Preservation Areas (APP. Therefore, river flow is unstable, promoting frequent flood damages, besides the lack of several environmental functions of its APPs. Environmental recovery of a degraded area requires a comprehensive effort, often multidisciplinary. Multicriterial analysis is a tool which allows gathering a diversity of attributes of the studied subject, weighing and valuating them, helping in the decision making effort. This work aims to apply two methods of multicriteria analysis to optimize the selection of a watershed for an environmental recovery study of APPs in the Anhumas watershed. The Anhumas watershed was divided in 7 sub-basins aiming the selection of one of those to implement an environmental planning study and to establish and rank areas that should be prioritized for recovery. Thirteen environmental criteria were selected for application of multicriteria analysis using the methods of Compromise Programming (PC and Cooperative Game Theory (CGT. Relevance of each criterion to the analysis was given by a questionnaire answered by specialists. Basin selection results showed no difference neither between PC and CGT nor between mean or mode used to standardize weights given by specialists. Multicriteria analysis was effective, but allowed enough flexibility for the decision maker (DM to adjust undesired analysis distortions. After DM adjustments, the priority basins were ranked as basins 4 > 7 > 5 > 6 > 2 > 3 > 1. Important procedures when carrying out such an analysis were to avoid conceptual overlapping among different criteria, to implement appropriate value judgment for each criterion and to use decision maker expertise to supplement weights obtained with specialists.

  10. Diagnostic of ribeirão Mestre d’Armas sub-basin using two methods of rapid environmental assessment, Federal District, Central Brazil

    Directory of Open Access Journals (Sweden)

    Julio Cesar Joveli

    2010-04-01

    Full Text Available Rapid environmental assessments have been used to describe the quality and semi-quantitative attributes of the ecosystems along an environmental gradient using visual observations and few measurements. The aim of this study was to identify and measure anthropogenic impacts on ribeirão Mestre d’Armas sub-basin, Federal District, Central Brazil, and to propose its environmental zoning. This study was performed using two methods based on rapid environmental assessment: a rapid river assessment protocol, to evaluate in an integrated form the features of a lotic system section according to the conservation or degradation condition of the fluvial environment; and the Leopold matrix, to identify and evaluate the anthropogenic impacts. The environmental zoning of this sub-basin detected three areas: preserved, transition and urban areas. The environmental assessment revealed, the preserved area had lotic stretches with natural features under low magnitude of impacts, except on burned areas. In the transition area, there was a predominance of lotic stretches with altered features, due to agriculture and livestock activities of intermediate level of impacts. Finally, the urban area had altered and impacted lotic stretches of higher magnitude due to anthropogenic impacts. Thus, this study revealed large differences among the areas detected by environmental zoning, according to the methods used. These methods were considered complementary in relation to environmental diagnostic of the ribeirão Mestre d’Armas sub-basin.

  11. Guidebook in using Cost Benefit Analysis and strategic environmental assessment for environmental planning in China

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2011-07-01

    Environmental planning in China may benefit from greater use of Cost Benefit Analysis (CBA) and Strategic Environmental Assessment (SEA) methodologies. We provide guidance on using these methodologies. Part I and II show the principles behind the methodologies as well as their theoretical structure. Part III demonstrates the methodologies in action in a range of different good practice examples. The case studies and theoretical expositions are intended to teach by way of example as well as by understanding the principles, and to help planners use the methodologies as correctly as possible.(auth)

  12. Diagnostic Stability of ICD/DSM First Episode Psychosis Diagnoses: Meta-analysis

    Science.gov (United States)

    Fusar-Poli, Paolo; Cappucciati, Marco; Rutigliano, Grazia; Heslin, Margaret; Stahl, Daniel; Brittenden, Zera; Caverzasi, Edgardo; McGuire, Philip; Carpenter, William T.

    2016-01-01

    Background: Validity of current International Classification of Disease/Diagnostic and Statistical Manual of Mental Disorders (ICD/DSM) first episode psychosis diagnoses is essential in clinical practice, research, training and public health. Method: We provide a meta-analytical estimate of prospective diagnostic stability and instability in ICD-10 or DSM-IV first episode diagnoses of functional psychoses. Independent extraction by multiple observers. Random effect meta-analysis conducted with the “metaprop,” “metaninf,” “metafunnel,” “metabias,” and “metareg” packages of STATA13.1. Moderators were tested with meta-regression analyses. Heterogeneity was assessed with the I 2 index. Sensitivity analyses tested robustness of results. Publication biases were assessed with funnel plots and Egger’s test. Findings: 42 studies and 45 samples were included, for a total of 14 484 first episode patients and an average follow-up of 4.5 years. Prospective diagnostic stability ranked: schizophrenia 0.90 (95% CI 0.85–0.95), affective spectrum psychoses 0.84 (95% CI 0.79–0.89), schizoaffective disorder 0.72 (95% CI 0.61–0.73), substance-induced psychotic disorder 0.66 (95% CI 0.51–0.81), delusional disorder 0.59 (95% CI 0.47–0.71), acute and transient psychotic disorder/brief psychotic disorder 0.56 (95% CI 0.62–0.60), psychosis not otherwise specified 0.36 (95% CI 0.27–0.45, schizophreniform disorder 0.29 (95% CI 0.22–0.38). Diagnostic stability within schizophrenia spectrum psychoses was 0.93 (95% CI 0.89–0.97); changes to affective spectrum psychoses were 0.05 (95% CI 0.01–0.08). About 0.10 (95% CI 0.05–0.15) of affective spectrum psychoses changed to schizophrenia spectrum psychosis. Across the other psychotic diagnoses there was high diagnostic instability, mostly to schizophrenia. Interpretation: There is meta-analytical evidence for high prospective diagnostic stability in schizophrenia spectrum and affective spectrum psychoses

  13. Sampling and chemical analysis in environmental samples around Nuclear Power Plants and some environmental samples

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yong Woo; Han, Man Jung; Cho, Seong Won; Cho, Hong Jun; Oh, Hyeon Kyun; Lee, Jeong Min; Chang, Jae Sook [KORTIC, Taejon (Korea, Republic of)

    2002-12-15

    Twelve kinds of environmental samples such as soil, seawater, underground water, etc. around Nuclear Power Plants(NPPs) were collected. Tritium chemical analysis was tried for the samples of rain water, pine-needle, air, seawater, underground water, chinese cabbage, a grain of rice and milk sampled around NPPs, and surface seawater and rain water sampled over the country. Strontium in the soil that sere sampled at 60 point of district in Korea were analyzed. Tritium were sampled at 60 point of district in Korea were analyzed. Tritium were analyzed in 21 samples of surface seawater around the Korea peninsular that were supplied from KFRDI(National Fisheries Research and Development Institute). Sampling and chemical analysis environmental samples around Kori, Woolsung, Youngkwang, Wooljin Npps and Taeduk science town for tritium and strontium analysis was managed according to plans. Succeed to KINS after all samples were tried.

  14. Environmental risk analysis of hazardous material rail transportation

    International Nuclear Information System (INIS)

    Saat, Mohd Rapik; Werth, Charles J.; Schaeffer, David; Yoon, Hongkyu; Barkan, Christopher P.L.

    2014-01-01

    Highlights: • Comprehensive, nationwide risk assessment of hazardous material rail transportation. • Application of a novel environmental (i.e. soil and groundwater) consequence model. • Cleanup cost and total shipment distance are the most significant risk factors. • Annual risk varies from $20,000 to $560,000 for different products. • Provides information on the risk cost associated with specific product shipments. -- Abstract: An important aspect of railroad environmental risk management involves tank car transportation of hazardous materials. This paper describes a quantitative, environmental risk analysis of rail transportation of a group of light, non-aqueous-phase liquid (LNAPL) chemicals commonly transported by rail in North America. The Hazardous Materials Transportation Environmental Consequence Model (HMTECM) was used in conjunction with a geographic information system (GIS) analysis of environmental characteristics to develop probabilistic estimates of exposure to different spill scenarios along the North American rail network. The risk analysis incorporated the estimated clean-up cost developed using the HMTECM, route-specific probability distributions of soil type and depth to groundwater, annual traffic volume, railcar accident rate, and tank car safety features, to estimate the nationwide annual risk of transporting each product. The annual risk per car-mile (car-km) and per ton-mile (ton-km) was also calculated to enable comparison between chemicals and to provide information on the risk cost associated with shipments of these products. The analysis and the methodology provide a quantitative approach that will enable more effective management of the environmental risk of transporting hazardous materials

  15. Environmental risk analysis of hazardous material rail transportation

    Energy Technology Data Exchange (ETDEWEB)

    Saat, Mohd Rapik, E-mail: mohdsaat@illinois.edu [Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, 1243 Newmark Civil Engineering Laboratory, 205 North Mathews Avenue, Urbana, IL 61801 (United States); Werth, Charles J.; Schaeffer, David [Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, 1243 Newmark Civil Engineering Laboratory, 205 North Mathews Avenue, Urbana, IL 61801 (United States); Yoon, Hongkyu [Sandia National Laboratories, Albuquerque, NM 87123 (United States); Barkan, Christopher P.L. [Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, 1243 Newmark Civil Engineering Laboratory, 205 North Mathews Avenue, Urbana, IL 61801 (United States)

    2014-01-15

    Highlights: • Comprehensive, nationwide risk assessment of hazardous material rail transportation. • Application of a novel environmental (i.e. soil and groundwater) consequence model. • Cleanup cost and total shipment distance are the most significant risk factors. • Annual risk varies from $20,000 to $560,000 for different products. • Provides information on the risk cost associated with specific product shipments. -- Abstract: An important aspect of railroad environmental risk management involves tank car transportation of hazardous materials. This paper describes a quantitative, environmental risk analysis of rail transportation of a group of light, non-aqueous-phase liquid (LNAPL) chemicals commonly transported by rail in North America. The Hazardous Materials Transportation Environmental Consequence Model (HMTECM) was used in conjunction with a geographic information system (GIS) analysis of environmental characteristics to develop probabilistic estimates of exposure to different spill scenarios along the North American rail network. The risk analysis incorporated the estimated clean-up cost developed using the HMTECM, route-specific probability distributions of soil type and depth to groundwater, annual traffic volume, railcar accident rate, and tank car safety features, to estimate the nationwide annual risk of transporting each product. The annual risk per car-mile (car-km) and per ton-mile (ton-km) was also calculated to enable comparison between chemicals and to provide information on the risk cost associated with shipments of these products. The analysis and the methodology provide a quantitative approach that will enable more effective management of the environmental risk of transporting hazardous materials.

  16. Meta-Analyst: software for meta-analysis of binary, continuous and diagnostic data

    Directory of Open Access Journals (Sweden)

    Schmid Christopher H

    2009-12-01

    Full Text Available Abstract Background Meta-analysis is increasingly used as a key source of evidence synthesis to inform clinical practice. The theory and statistical foundations of meta-analysis continually evolve, providing solutions to many new and challenging problems. In practice, most meta-analyses are performed in general statistical packages or dedicated meta-analysis programs. Results Herein, we introduce Meta-Analyst, a novel, powerful, intuitive, and free meta-analysis program for the meta-analysis of a variety of problems. Meta-Analyst is implemented in C# atop of the Microsoft .NET framework, and features a graphical user interface. The software performs several meta-analysis and meta-regression models for binary and continuous outcomes, as well as analyses for diagnostic and prognostic test studies in the frequentist and Bayesian frameworks. Moreover, Meta-Analyst includes a flexible tool to edit and customize generated meta-analysis graphs (e.g., forest plots and provides output in many formats (images, Adobe PDF, Microsoft Word-ready RTF. The software architecture employed allows for rapid changes to be made to either the Graphical User Interface (GUI or to the analytic modules. We verified the numerical precision of Meta-Analyst by comparing its output with that from standard meta-analysis routines in Stata over a large database of 11,803 meta-analyses of binary outcome data, and 6,881 meta-analyses of continuous outcome data from the Cochrane Library of Systematic Reviews. Results from analyses of diagnostic and prognostic test studies have been verified in a limited number of meta-analyses versus MetaDisc and MetaTest. Bayesian statistical analyses use the OpenBUGS calculation engine (and are thus as accurate as the standalone OpenBUGS software. Conclusion We have developed and validated a new program for conducting meta-analyses that combines the advantages of existing software for this task.

  17. Diagnostics for generalized linear hierarchical models in network meta-analysis.

    Science.gov (United States)

    Zhao, Hong; Hodges, James S; Carlin, Bradley P

    2017-09-01

    Network meta-analysis (NMA) combines direct and indirect evidence comparing more than 2 treatments. Inconsistency arises when these 2 information sources differ. Previous work focuses on inconsistency detection, but little has been done on how to proceed after identifying inconsistency. The key issue is whether inconsistency changes an NMA's substantive conclusions. In this paper, we examine such discrepancies from a diagnostic point of view. Our methods seek to detect influential and outlying observations in NMA at a trial-by-arm level. These observations may have a large effect on the parameter estimates in NMA, or they may deviate markedly from other observations. We develop formal diagnostics for a Bayesian hierarchical model to check the effect of deleting any observation. Diagnostics are specified for generalized linear hierarchical NMA models and investigated for both published and simulated datasets. Results from our example dataset using either contrast- or arm-based models and from the simulated datasets indicate that the sources of inconsistency in NMA tend not to be influential, though results from the example dataset suggest that they are likely to be outliers. This mimics a familiar result from linear model theory, in which outliers with low leverage are not influential. Future extensions include incorporating baseline covariates and individual-level patient data. Copyright © 2017 John Wiley & Sons, Ltd.

  18. Diagnostic tests’ decision-making rules based upon analysis of ROC-curves

    Directory of Open Access Journals (Sweden)

    Л. В. Батюк

    2015-10-01

    Full Text Available In this paper we propose the model which substantiates diagnostics decision making based on the analysis of Receiver Operating Characteristic curves (ROC-curves and predicts optimal values of diagnostic indicators of biomedical information. To assess the quality of the test result prediction the standard criteria of the sensitivity and specificity of the model were used. Values of these criteria were calculated for the cases when the sensitivity of the test was greater than specificity by several times, when the number of correct diagnoses was maximal, when the sensitivity of the test was equal to its specificity and the sensitivity of the test was several times greater than the specificity of the test. To assess the significance of the factor characteristics and to compare the prognostic characteristics of models we used mathematical modeling and plotting the ROC-curves. The optimal value of the diagnostic indicator was found to be achieved when the sensitivity of the test is equal to its specificity. The model was adapted to solve the case when the sensitivity of the test is greater than specificity of the test.

  19. Preliminary results of the analysis of the administered activities in diagnostic studies of nuclear medicine

    International Nuclear Information System (INIS)

    Lopez Bejerano, G.; Sed, L.J.

    2001-01-01

    The worldwide use of Nuclear Medicine diagnostic procedures and the tendency to its increment, infers an important exposure of the population to ionising radiation; it has motivated that the IAEA in the International Basic Safety Standards (BSS), emits recommendations for the establishment of guidance levels of activities administered to the patients in diagnostic procedures. Taking into account the above-mentioned and that in Cuba there exist 20 departments of Nuclear Medicine that in the majority possess equipment with more than 20 years of operation, which influences directly the medical exposure. A survey was designed and applied in 10 of these departments. The survey evaluates the compliance with the BSS requirements, and specifically, the activities administered to the patients in Nuclear Medicine diagnostic procedures are analysed. In the present work the obtained preliminary results of the statistical analysis carried out on the activity values used in Nuclear Medicine departments are presented, and comparisons made for a proposal of guidance levels for the national practice, which is compared with those recommended internationally. (author)

  20. Environmental/Economic Analysis and Recycling of Wastes from Air ...

    African Journals Online (AJOL)

    Environmental and economic analysis was performed on the wastes from Air Liquid Nigeria Ltd. The company's waste water, spent oil, noise and air pollutants were examined. Results show no serious adverse impact on the ambient air quality. There was serious noise pollution problem around the factory hall and generator ...

  1. GIS and correlation analysis of geo-environmental variables ...

    African Journals Online (AJOL)

    GIS and correlation analysis of geo-environmental variables influencing malaria prevalence in the Saboba district of Northern Ghana. ... The study also applied spline interpolation technique to map malaria prevalence in the district using standardised malaria incidence. The result indicates that distance to marshy areas is ...

  2. The diagnostic accuracy of multi-frequency bioelectrical impedance analysis in diagnosing dehydration after stroke

    Science.gov (United States)

    Kafri, Mohannad W.; Myint, Phyo Kyaw; Doherty, Danielle; Wilson, Alexander Hugh; Potter, John F.; Hooper, Lee

    2013-01-01

    Background Non-invasive methods for detecting water-loss dehydration following acute stroke would be clinically useful. We evaluated the diagnostic accuracy of multi-frequency bioelectrical impedance analysis (MF-BIA) against reference standards serum osmolality and osmolarity. Material/Methods Patients admitted to an acute stroke unit were recruited. Blood samples for electrolytes and osmolality were taken within 20 minutes of MF-BIA. Total body water (TBW%), intracellular (ICW%) and extracellular water (ECW%), as percentages of total body weight, were calculated by MF-BIA equipment and from impedance measures using published equations for older people. These were compared to hydration status (based on serum osmolality and calculated osmolarity). The most promising Receiver Operating Characteristics curves were plotted. Results 27 stroke patients were recruited (mean age 71.3, SD10.7). Only a TBW% cut-off at 46% was consistent with current dehydration (serum osmolality >300 mOsm/kg) and TBW% at 47% impending dehydration (calculated osmolarity ≥295–300 mOsm/L) with sensitivity and specificity both >60%. Even here diagnostic accuracy of MF-BIA was poor, a third of those with dehydration were wrongly classified as hydrated and a third classified as dehydrated were well hydrated. Secondary analyses assessing diagnostic accuracy of TBW% for men and women separately, and using TBW as a percentage of lean body mass showed some promise, but did not provide diagnostically accurate measures across the population. Conclusions MF-BIA appears ineffective at diagnosing water-loss dehydration after stroke and cannot be recommended as a test for dehydration, but separating assessment by sex, and using TBW as a percentage of lean body weight may warrant further investigation. PMID:23839255

  3. Environmental management in sugar-energy sector: a comparative analysis

    Directory of Open Access Journals (Sweden)

    Andréia Marize Rodrigues

    2014-11-01

    Full Text Available With the rise of the environmental variable in the business environment, companies started to give greater attention to strategies and practices focused on the rational use of natural resources and minimize the environmental impacts of their business operations. Many productive sectors stood out in the reflections on production and the environment, as is the case of the sugar energy industry, which constitutes a sector with a highly demanding industrial activity of natural resources, whether as sources of inputs as depositories of waste production. Thus, the aim of this paper is a comparative analysis of environmental practices of two sugar energy plants, both from the point of view of their operational strategy and regarding the suitability of the disposal of waste generated by the industrial area. It was concluded that, although many practices adopted by businesses are analogous, one of the studied plants have distinctive environmental performance, because of the increased attention given to the implementation of environmental practices and especially the inclusion of the environmental variable in their strategies.

  4. Environmental metabolomics: a SWOT analysis (strengths, weaknesses, opportunities, and threats).

    Science.gov (United States)

    Miller, Marion G

    2007-02-01

    Metabolomic approaches have the potential to make an exceptional contribution to understanding how chemicals and other environmental stressors can affect both human and environmental health. However, the application of metabolomics to environmental exposures, although getting underway, has not yet been extensively explored. This review will use a SWOT analysis model to discuss some of the strengths, weaknesses, opportunities, and threats that are apparent to an investigator venturing into this relatively new field. SWOT has been used extensively in business settings to uncover new outlooks and identify problems that would impede progress. The field of environmental metabolomics provides great opportunities for discovery, and this is recognized by a high level of interest in potential applications. However, understanding the biological consequence of environmental exposures can be confounded by inter- and intra-individual differences. Metabolomic profiles can yield a plethora of data, the interpretation of which is complex and still being evaluated and researched. The development of the field will depend on the availability of technologies for data handling and that permit ready access metabolomic databases. Understanding the relevance of metabolomic endpoints to organism health vs adaptation vs variation is an important step in understanding what constitutes a substantive environmental threat. Metabolomic applications in reproductive research are discussed. Overall, the development of a comprehensive mechanistic-based interpretation of metabolomic changes offers the possibility of providing information that will significantly contribute to the protection of human health and the environment.

  5. Diagnostic accuracy of quantitative 99mTc-MIBI scintimammography according to ROC curve analysis

    International Nuclear Information System (INIS)

    Kim, J. H.; Lee, H. K.; Seo, J. W.; Cho, N. S.; Cha, K. H.; Lee, T. H.

    1998-01-01

    99mTc-sestamibi scintimammography (SMM) has been shown to be a useful diagnostic test in the detection of breast cancer and the receiver operating characteristic (ROC) curve analysis provides detailed information of a diagnostic test. The purpose of this study was to evaluate the feasibility and efficacy of quantitative indices of SMM in the detection of malignant breast lesions according to ROC analysis. Prone anterior, lateral planar and supine SPECT imagings were performed on 75 female patients (mean age=43.4 yr) with breast mass (size≥0.8cm) after intravenous injection of 20-30 mCi 99mTc-sestamibi. 45 Malignant (Invasive ductal ca(36), Inv lobular ca(5), Inv duc + lob (1), Inv tubular ca (3)) and 30 benign (fibroadenoma (13), fib cyst(12), Fat necrosis(3), papilloma(1), paraffinoma (1)) lesions were histologically proven. Data were analyzed by creating three regions of interest (ROIs) over designated areas: lesion, normal breast and right chest wall. Lesion to normal (L/NL) and lesion to chest wall (L/CW) ratios were calculated for each patient both on the planar and SPECT. The area under the ROC curve (AUC) was calculated and compared among four semiquantitative indices and an average scintimammographic index (SMM(mean)) from arithmatic mean. ROC curve analysis revealed planar L/N, SPECT L/N and L/CW ratios provide comparable better diagnostic accuracies for detection of breast cancer than planar L/CW ratio (p<0.05), respectively. For quantitative SMM of 75 lesions, malignancy rate was 60%, and Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value and Accuracy were 0.78, 0.77, 0.84, 0.72 and 0.77, respectively. Quantitative SMM is an useful objective method for differentiating malignant from benign breast lesions

  6. Feature-tracking myocardial strain analysis in acute myocarditis. Diagnostic value and association with myocardial oedema

    International Nuclear Information System (INIS)

    Luetkens, Julian A.; Schlesinger-Irsch, Ulrike; Kuetting, Daniel L.; Dabir, Darius; Homsi, Rami; Schmeel, Frederic C.; Sprinkart, Alois M.; Naehle, Claas P.; Schild, Hans H.; Thomas, Daniel; Doerner, Jonas; Fimmers, Rolf

    2017-01-01

    To investigate the diagnostic value of cardiac magnetic resonance (CMR) feature-tracking (FT) myocardial strain analysis in patients with suspected acute myocarditis and its association with myocardial oedema. Forty-eight patients with suspected acute myocarditis and 35 control subjects underwent CMR. FT CMR analysis of systolic longitudinal (LS), circumferential (CS) and radial strain (RS) was performed. Additionally, the protocol allowed for the assessment of T1 and T2 relaxation times. When compared with healthy controls, myocarditis patients demonstrated reduced LS, CS and RS values (LS: -19.5 ± 4.4% vs. -23.6 ± 3.1%, CS: -23.0 ± 5.8% vs. -27.4 ± 3.4%, RS: 28.9 ± 8.5% vs. 32.4 ± 7.4%; P < 0.05, respectively). LS (T1: r = 0.462, P < 0.001; T2: r = 0.436, P < 0.001) and CS (T1: r = 0.429, P < 0.001; T2: r = 0.467, P < 0.001) showed the strongest correlations with T1 and T2 relaxations times. Area under the curve of LS (0.79) was higher compared with those of CS (0.75; P = 0.478) and RS (0.62; P = 0.008). FT CMR myocardial strain analysis might serve as a new tool for assessment of myocardial dysfunction in the diagnostic work-up of patients suspected of having acute myocarditis. Especially, LS and CS show a sufficient diagnostic performance and were most closely correlated with CMR parameters of myocardial oedema. (orig.)

  7. Feature-tracking myocardial strain analysis in acute myocarditis. Diagnostic value and association with myocardial oedema

    Energy Technology Data Exchange (ETDEWEB)

    Luetkens, Julian A.; Schlesinger-Irsch, Ulrike; Kuetting, Daniel L.; Dabir, Darius; Homsi, Rami; Schmeel, Frederic C.; Sprinkart, Alois M.; Naehle, Claas P.; Schild, Hans H.; Thomas, Daniel [University of Bonn, Department of Radiology, Bonn (Germany); Doerner, Jonas [University Hospital Cologne, Department of Radiology, Cologne (Germany); Fimmers, Rolf [University of Bonn, Department of Medical Biometry, Informatics, and Epidemiology, Bonn (Germany)

    2017-11-15

    To investigate the diagnostic value of cardiac magnetic resonance (CMR) feature-tracking (FT) myocardial strain analysis in patients with suspected acute myocarditis and its association with myocardial oedema. Forty-eight patients with suspected acute myocarditis and 35 control subjects underwent CMR. FT CMR analysis of systolic longitudinal (LS), circumferential (CS) and radial strain (RS) was performed. Additionally, the protocol allowed for the assessment of T1 and T2 relaxation times. When compared with healthy controls, myocarditis patients demonstrated reduced LS, CS and RS values (LS: -19.5 ± 4.4% vs. -23.6 ± 3.1%, CS: -23.0 ± 5.8% vs. -27.4 ± 3.4%, RS: 28.9 ± 8.5% vs. 32.4 ± 7.4%; P < 0.05, respectively). LS (T1: r = 0.462, P < 0.001; T2: r = 0.436, P < 0.001) and CS (T1: r = 0.429, P < 0.001; T2: r = 0.467, P < 0.001) showed the strongest correlations with T1 and T2 relaxations times. Area under the curve of LS (0.79) was higher compared with those of CS (0.75; P = 0.478) and RS (0.62; P = 0.008). FT CMR myocardial strain analysis might serve as a new tool for assessment of myocardial dysfunction in the diagnostic work-up of patients suspected of having acute myocarditis. Especially, LS and CS show a sufficient diagnostic performance and were most closely correlated with CMR parameters of myocardial oedema. (orig.)

  8. Diagnostic accuracy of quantitative 99mTc-MIBI scintimammography according to ROC curve analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. H.; Lee, H. K.; Seo, J. W.; Cho, N. S.; Cha, K. H.; Lee, T. H. [Gachon Medical College, Gil Medical Center, Inchon (Korea, Republic of)

    1998-07-01

    99mTc-sestamibi scintimammography (SMM) has been shown to be a useful diagnostic test in the detection of breast cancer and the receiver operating characteristic (ROC) curve analysis provides detailed information of a diagnostic test. The purpose of this study was to evaluate the feasibility and efficacy of quantitative indices of SMM in the detection of malignant breast lesions according to ROC analysis. Prone anterior, lateral planar and supine SPECT imagings were performed on 75 female patients (mean age=43.4 yr) with breast mass (size{>=}0.8cm) after intravenous injection of 20-30 mCi 99mTc-sestamibi. 45 Malignant (Invasive ductal ca(36), Inv lobular ca(5), Inv duc + lob (1), Inv tubular ca (3)) and 30 benign (fibroadenoma (13), fib cyst(12), Fat necrosis(3), papilloma(1), paraffinoma (1)) lesions were histologically proven. Data were analyzed by creating three regions of interest (ROIs) over designated areas: lesion, normal breast and right chest wall. Lesion to normal (L/NL) and lesion to chest wall (L/CW) ratios were calculated for each patient both on the planar and SPECT. The area under the ROC curve (AUC) was calculated and compared among four semiquantitative indices and an average scintimammographic index (SMM(mean)) from arithmatic mean. ROC curve analysis revealed planar L/N, SPECT L/N and L/CW ratios provide comparable better diagnostic accuracies for detection of breast cancer than planar L/CW ratio (p<0.05), respectively. For quantitative SMM of 75 lesions, malignancy rate was 60%, and Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value and Accuracy were 0.78, 0.77, 0.84, 0.72 and 0.77, respectively. Quantitative SMM is an useful objective method for differentiating malignant from benign breast lesions.

  9. Substantia nigra fractional anisotropy is not a diagnostic biomarker of Parkinson's disease: A diagnostic performance study and meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Hirata, Fabiana C.C.; Vieira, Gilson; Lucato, Leandro T.; Leite, Claudia C.; Pastorello, Bruno F.; Otaduy, Maria C.G.; Chaim, Khallil T.; Campanholo, Kenia R. [University of Sao Paulo, LIM-44, Department of Radiology, Sao Paulo, SP (Brazil); Sato, Joao R. [University of Sao Paulo, LIM-44, Department of Radiology, Sao Paulo, SP (Brazil); Universidade Federal do ABC, Center of Mathematics, Computation and Cognition, Santo Andre (Brazil); Bor-Seng-Shu, Edson; Novaes, Natalia P. [Hospital Israelita Albert Einstein, Sao Paulo (Brazil); University of Sao Paulo, Department of Neurology, Sao Paulo (Brazil); Magalhaes Melo, Luciano; Goncalves, Marcia R.; Reis Barbosa, Egberto [University of Sao Paulo, Department of Neurology, Sao Paulo (Brazil); Pereira do Nascimento, Felipe Barjud; Amaro, Edson [University of Sao Paulo, LIM-44, Department of Radiology, Sao Paulo, SP (Brazil); Hospital Israelita Albert Einstein, Sao Paulo (Brazil); Jacobsen Teixeira, Manoel [University of Sao Paulo, Department of Neurosurgery, Sao Paulo (Brazil); Cardoso, Ellison Fernando [University of Sao Paulo, LIM-44, Department of Radiology, Sao Paulo, SP (Brazil); Hospital Israelita Albert Einstein, Sao Paulo (Brazil); Institute of Mathematics and Statistics University of Sao Paulo (IME-USP), Sao Paulo (Brazil)

    2017-06-15

    Our goal was to estimate the diagnostic accuracy of substantia nigra fractional anisotropy (SN-FA) for Parkinson's disease (PD) diagnosis in a sample similar to the clinical setting, including patients with essential tremor (ET) and healthy controls (HC). We also performed a systematic review and meta-analysis to estimate mean change in SN-FA induced by PD and its diagnostic accuracy. Our sample consisted of 135 subjects: 72 PD, 21 ET and 42 HC. To address inter-scanner variability, two 3.0-T MRI scans were performed. MRI results of this sample were pooled into a meta-analysis that included 1,432 subjects (806 PD and 626 HC). A bivariate model was used to evaluate diagnostic accuracy measures. In our sample, we did not observe a significant effect of disease on SN-FA and it was uninformative for diagnosis. The results of the meta-analysis estimated a 0.03 decrease in mean SN-FA in PD relative to HC (CI: 0.01-0.05). However, the discriminatory capability of SN-FA to diagnose PD was low: pooled sensitivity and specificity were 72 % (CI: 68-75) and 63 % (CI: 58-70), respectively. There was high heterogeneity between studies (I{sup 2} = 91.9 %). SN-FA cannot be used as an isolated measure to diagnose PD. (orig.)

  10. Cosmological reconstruction and Om diagnostic analysis of Einstein-Aether theory

    Energy Technology Data Exchange (ETDEWEB)

    Pasqua, Antonio [Department of Physics, University of Trieste, Via Valerio 2, 34127 Trieste (Italy); Chattopadhyay, Surajit [Pailan College of Management and Technology, Bengal Pailan Park, Kolkata-700 104 (India); Momeni, Davood; Myrzakulov, Ratbay [Eurasian International Center for Theoretical Physics and Department of General and Theoretical Physics, Eurasian National University, Astana 010008 (Kazakhstan); Raza, Muhammad [Department of Mathematics, COMSATS Institute of Information Technology, Sahiwal 57000 (Pakistan); Faizal, Mir, E-mail: toto.pasqua@gmail.com, E-mail: surajcha@iucaa.ernet.in, E-mail: d.momeni@yahoo.com, E-mail: mraza@zju.edu.cn, E-mail: rmyrzakulov@gmail.com, E-mail: mirfaizalmir@gmail.com [Irving K. Barber School of Arts and Sciences, University of British Columbia—Okanagan, Kelowna, British Columbia V1V 1V7 (Canada)

    2017-04-01

    In this paper, we analyze the cosmological models in Einstein-Aether gravity, which is a modified theory of gravity in which a time-like vector field breaks the Lorentz symmetry. We use this formalism to analyse different cosmological models with different behavior of the scale factor. In this analysis, we use a certain functional dependence of the Dark Energy (DE) on the Hubble parameter H . It will be demonstrated that the Aether vector field has a non-trivial effect on these cosmological models. We also perform the Om diagnostic in Einstein-Aether gravity and we fit the parameters of the cosmological models using recent observational data.

  11. Diagnostic imaging for chronic plantar heel pain: a systematic review and meta-analysis

    Directory of Open Access Journals (Sweden)

    Barrett Joanna T

    2009-11-01

    Full Text Available Abstract Background Chronic plantar heel pain (CPHP is a generalised term used to describe a range of undifferentiated conditions affecting the plantar heel. Plantar fasciitis is reported as the most common cause and the terms are frequently used interchangeably in the literature. Diagnostic imaging has been used by many researchers and practitioners to investigate the involvement of specific anatomical structures in CPHP. These observations help to explain the underlying pathology of the disorder, and are of benefit in forming an accurate diagnosis and targeted treatment plan. The purpose of this systematic review was to investigate the diagnostic imaging features associated with CPHP, and evaluate study findings by meta-analysis where appropriate. Methods Bibliographic databases including Medline, Embase, CINAHL, SportDiscus and The Cochrane Library were searched electronically on March 25, 2009. Eligible articles were required to report imaging findings in participants with CPHP unrelated to inflammatory arthritis, and to compare these findings with a control group. Methodological quality was evaluated by use of the Quality Index as described by Downs and Black. Meta-analysis of study data was conducted where appropriate. Results Plantar fascia thickness as measured by ultrasonography was the most widely reported imaging feature. Meta-analysis revealed that the plantar fascia of CPHP participants was 2.16 mm thicker than control participants (95% CI = 1.60 to 2.71 mm, P P = 0.01. CPHP participants were also more likely to show radiographic evidence of subcalcaneal spur than control participants (OR = 8.52, 95% CI = 4.08 to 17.77, P Conclusion This systematic review has identified 23 studies investigating the diagnostic imaging appearance of the plantar fascia and inferior calcaneum in people with CPHP. Analysis of these studies found that people with CPHP are likely to have a thickened plantar fascia with associated fluid collection, and that

  12. Diagnostic value of polymerase chain reaction analysis of skin biopsies in purpura fulminans.

    Science.gov (United States)

    Beau, Caroline; Vlassova, Natalia; Sarlangue, Jean; Brissaud, Olivier; Léauté-Labrèze, Christine; Boralevi, Franck

    2013-01-01

    Even though prompt diagnosis and treatment of purpura fulminans (PF) is essential to reduce mortality, early administration of antibiotics may preclude identification of the causative agent by standard bacterial cultures and thus render definitive diagnosis impossible. Here we present a case of an infant with PF and negative bacterial cultures for whom polymerase chain reaction (PCR) analysis of a cutaneous biopsy specimen obtained 4 days after initiation of antibiotics identified the genomic sequence of Neisseria meningitidis genogroup C. When bacterial cultures fail to provide useful information, PCR of skin biopsy specimens can be a valuable diagnostic tool in PF. © 2013 Wiley Periodicals, Inc.

  13. T-scan III system diagnostic tool for digital occlusal analysis in orthodontics - a modern approach.

    Science.gov (United States)

    Trpevska, Vesna; Kovacevska, Gordana; Benedeti, Alberto; Jordanov, Bozidar

    2014-01-01

    This systematic literature review was performed to establish the mechanism, methodology, characteristics, clinical application and opportunities of the T-Scan III System as a diagnostic tool for digital occlusal analysis in different fields of dentistry, precisely in orthodontics. Searching of electronic databases, using MEDLINE and PubMed, hand searching of relevant key journals, and screening of reference lists of included studies with no language restriction was performed. Publications providing statistically examined data were included for systematic review. Twenty potentially relevant Randomized Controlled Trials (RCTs) were identified. Only ten met the inclusion criteria. The literature demonstrates that using digital occlusal analysis with T-Scan III System in orthodontics has significant advantage with regard to the capability of measuring occlusal parameters in static positions and during dynamic of the mandible. Within the scope of this systematic review, there is evidence to support that T-Scan system is rapid and accurate in identifying the distribution of the tooth contacts and it shows great promise as a clinical diagnostic screening device for occlusion and for improving the occlusion after various dental treatments. Additional clinical studies are required to advance the indication filed of this system. Importance of using digital occlusal T-Scan analysis in orthodontics deserves further investigation.

  14. Analysis of changes in environmental radiation, and three types of environmental radiation detector performance comparisons

    International Nuclear Information System (INIS)

    Park, J.H; Seo, J.H; Park, S.M; Yu, B.N; Park, J.H; Joo, K.S

    2013-06-01

    High-pressure ion chamber (GE Reuter-Stokes, HPIC), accuracy is high but the high price and do not have the ability nuclide analysis is a disadvantage. NaI(Tl) and PMT scintillation detector of radioactive materials can be divided. Environmental radiation measurements using a semiconductor with SiPM detector PMT to replace the value of the results were compared. SiPM detector using radiation environment were measured in the field to verify the accuracy and energy resolution. SiPMs performance as environmental radiation measurement equipment and radioactive material distinction as a personal dosimeter based technology, using the above results were prepared. The interest on the environmental radiation due to the Fukushima power plant crisis in Japan has been growing concern about the radiation environment of the relatively close proximity Korea is a very heightened state. Could be confirmed in the radiation environment of nuclear power plants around the analysis and performance of the next generation of environmental radiation meter. Fukushima power plants accident after 2 years, the equipment installed by this analysis meets the performance as a radiation detector could be confirmed as follows. CANA Inc. developed by radionuclides classification of using man-made and natural radionuclides and man-made radionuclides separated, ensure the value of the results were analyzed. Could be and alternative to the conventional detector energy resolution ( 137 CS<15%) and linearity (<15%) to satisfy the performance requirements of the measurement result of environmental radiation detector is considered. SiPM radiation environment changes and HPIC and NaI(TI) scintillation detector installed in Korea of the Fukushima power plant after the accident, radiation environment using a small alternative was to verify the accuracy of the measuring equipment. A big difference in performance as invisible by comparison with the large detector Assay miniaturization rough as a personal

  15. The Environmental Scenario Generator (ESG: a distributed environmental data archive analysis tool

    Directory of Open Access Journals (Sweden)

    E A Kihn

    2006-01-01

    Full Text Available The Environmental Scenario Generator (ESG is a network distributed software system designed to allow a user to interact with archives of environmental data for the purpose of scenario extraction, data analysis and integration with existing models that require environmental input. The ESG uses fuzzy-logic based search tools to allow a user to look for specific environmental scenarios in vast archives by specifying the search in human linguistic terms. For example, the user can specify a scenario such as a "cloud free week" or "high winds and low pressure" and then search relevant archives available across the network to get a list of matching events. The ESG hooks to existing archives of data by providing a simple communication framework and an efficient data model for exchanging data. Once data has been delivered by the distributed archives in the ESG data model, it can easily be accessed by the visualization, integration and analysis components to meet specific user requests. The ESG implementation provides a framework which can be taken as a pattern applicable to other distributed archive systems.

  16. Image acquisition and analysis for beam diagnostics, applications of the Taiwan photon source

    International Nuclear Information System (INIS)

    Liao, C.Y.; Chen, J.; Cheng, Y.S.; Hsu, K.T.; Hu, K.H.; Kuo, C.H.; Wu, C.Y.

    2012-01-01

    Design and implementation of image acquisition and analysis is in proceeding for the Taiwan Photon Source (TPS) diagnostic applications. The optical system contains screen, lens, and lighting system. A CCD camera with Gigabit Ethernet interface (GigE Vision) will be a standard image acquisition device. Image acquisition will be done on EPICS IOC via PV channel and analysis the properties by using Matlab tool to evaluate the beam profile (sigma), beam size position and tilt angle et al. The EPICS IOC integrated with Matlab as a data processing system is not only could be used in image analysis but also in many types of equipment data processing applications. Progress of the project will be summarized in this report. (authors)

  17. Environmental cost/benefit analysis for fusion power plants

    International Nuclear Information System (INIS)

    Young, J.R.

    1976-11-01

    This document presents a cost/benefit analysis of use of fusion power plants early in the 21st century. The first section describes the general formulation of the analysis. Included are the selection of the alternatives to the fusion reactor, selection of the power system cases to be compared, and a general comparison of the environmental effects of the selected alternatives. The second section compares the cumulative environmental effects from 2010 to 2040 for the primary cases of the power system with and without fusion reactors. The third section briefly illustrates the potential economic benefits if fusion reactors produce electricity at a lower unit cost than LMFBRs can. The fourth section summarizes the cost/benefit analysis

  18. Analysis in environmental radioactivity around Nuclear Power Plants

    Energy Technology Data Exchange (ETDEWEB)

    Cho, Yong Woo; Han, Man Jung; Cho, Seong Won; Cho, Hong Jun; Oh, Hyeon Kyun; Lee, Jeong Min; Chang, Jae Sook [KORTIC, Taejon (Korea, Republic of)

    2003-12-15

    Twelve kinds of environmental samples such as soil, seawater, underground water, etc. around Nuclear Power Plants(NPPs) were collected. Tritium chemical analysis was tried for the samples of rain water, pine-needle, air, seawater, underground water, chinese cabbage, again of rice and milk sampled around NPPs, and surface seawater and rain water sampled over the country. Strontium in the soil that were sampled at 60 point of district in Korea were analyzed. Tritium were analyzed in 21 samples of surface seawater around the Korea peninsular that were supplied form KFRDI(National Fisheries Research and Development Institute). Sampling and chemical analysis environmental samples around Kori, Woolsung, Youngkwang, Wooljin NPPs and Taeduk science town for tritium and strontium analysis was managed according to plans. Succeed to KINS after all samples were tried.

  19. Latent class analysis of diagnostic science assessment data using Bayesian networks

    Science.gov (United States)

    Steedle, Jeffrey Thomas

    2008-10-01

    Diagnostic science assessments seek to draw inferences about student understanding by eliciting evidence about the mental models that underlie students' reasoning about physical systems. Measurement techniques for analyzing data from such assessments embody one of two contrasting assessment programs: learning progressions and facet-based assessments. Learning progressions assume that students have coherent theories that they apply systematically across different problem contexts. In contrast, the facet approach makes no such assumption, so students should not be expected to reason systematically across different problem contexts. A systematic comparison of these two approaches is of great practical value to assessment programs such as the National Assessment of Educational Progress as they seek to incorporate small clusters of related items in their tests for the purpose of measuring depth of understanding. This dissertation describes an investigation comparing learning progression and facet models. Data comprised student responses to small clusters of multiple-choice diagnostic science items focusing on narrow aspects of understanding of Newtonian mechanics. Latent class analysis was employed using Bayesian networks in order to model the relationship between students' science understanding and item responses. Separate models reflecting the assumptions of the learning progression and facet approaches were fit to the data. The technical qualities of inferences about student understanding resulting from the two models were compared in order to determine if either modeling approach was more appropriate. Specifically, models were compared on model-data fit, diagnostic reliability, diagnostic certainty, and predictive accuracy. In addition, the effects of test length were evaluated for both models in order to inform the number of items required to obtain adequately reliable latent class diagnoses. Lastly, changes in student understanding over time were studied with a

  20. Pain in diagnostic hysteroscopy: a multivariate analysis after a randomized, controlled trial.

    Science.gov (United States)

    Mazzon, Ivan; Favilli, Alessandro; Grasso, Mario; Horvath, Stefano; Bini, Vittorio; Di Renzo, Gian Carlo; Gerli, Sandro

    2014-11-01

    To study which variables are able to influence women's experience of pain during diagnostic hysteroscopy. Multivariate analysis (phase II) after a randomized, controlled trial (phase I). Endoscopic gynecologic center. In phase I, 392 patients were analyzed. Group A: 197 women with carbon dioxide (CO2); group B: 195 women with normal saline. In phase II, 392 patients were assigned to two different groups according to their pain experience as measured by a visual analogue scale (VAS): group VAS>3 (170 patients); group VAS≤3 (222 patients). Free-anesthesia diagnostic hysteroscopy performed using CO2 or normal saline as distension media. Procedure time, VAS score, image quality, and side effects during and after diagnostic hysteroscopy. In phase I the median pain score in group A was 2, whereas in group B it was 3. In phase II the duration of the procedure, nulliparity, and the use of normal saline were significantly correlated with VAS>3. A higher presence of cervical synechiae was observed in the group VAS>3. The multivariate analysis revealed an inverse correlation between parity and a VAS>3, whereas the use of normal saline, the presence of synechiae in the cervical canal, and the duration of the hysteroscopy were all directly correlated to a VAS score>3. Pain in hysteroscopy is significantly related to the presence of cervical synechiae, to the duration of the procedure, and to the use of normal saline; conversely, parity seems to have a protective role. NCT01873391. Copyright © 2014 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

  1. Diagnostic assessment of intraoperative cytology for papillary thyroid carcinoma: using a decision tree analysis.

    Science.gov (United States)

    Pyo, J-S; Sohn, J H; Kang, G

    2017-03-01

    The aim of this study was to elucidate the cytological characteristics and the diagnostic usefulness of intraoperative cytology (IOC) for papillary thyroid carcinoma (PTC). In addition, using decision tree analysis, effective features for accurate cytological diagnosis were sought. We investigated cellularity, cytological features and diagnosis based on the Bethesda System for Reporting Thyroid Cytopathology in IOC of 240 conventional PTCs. The cytological features were evaluated in terms of nuclear score with nuclear features, and additional figures such as presence of swirling sheets, psammoma bodies, and multinucleated giant cells. The nuclear score (range 0-7) was made via seven nuclear features, including (1) enlarged, (2) oval or irregularly shaped nuclei, (3) longitudinal nuclear grooves, (4) intranuclear cytoplasmic pseudoinclusion, (5) pale nuclei with powdery chromatin, (6) nuclear membrane thickening, and (7) marginally placed micronucleoli. Nuclear scores in PTC, suspicious for malignancy, and atypia of undetermined significance cases were 6.18 ± 0.80, 4.48 ± 0.82, and 3.15 ± 0.67, respectively. Additional figures more frequent in PTC than in other diagnostic categories were identified. Cellularity of IOC significantly correlated with tumor size, nuclear score, and presence of additional figures. Also, IOCs with higher nuclear scores (4-7) significantly correlated with larger tumor size and presence of additional figures. In decision tree analysis, IOCs with nuclear score >5 and swirling sheets could be considered diagnostic for PTCs. Our study suggests that IOCs using nuclear features and additional figures could be useful with decreasing the likelihood of inconclusive results.

  2. THE ROLE AND PLACE OF LOGISTIC REGRESSION AND ROC ANALYSIS IN SOLVING MEDICAL DIAGNOSTIC TASK

    Directory of Open Access Journals (Sweden)

    S. G. Grigoryev

    2016-01-01

    Full Text Available Diagnostics, equally with  prevention and  treatment, is a basis of medical science and practice. For its history the medicine  has accumulated a great variety  of diagnostic methods for different diseases and  pathologic conditions. Nevertheless, new  tests,  methods and  tools are being  developed and recommended to application nowadays. Such  indicators as sensitivity and  specificity which  are defined on the basis  of fourfold contingency  tables   construction or  ROC-analysis method with  ROC  – curve  modelling (Receiver operating characteristic are used  as the  methods to estimate the  diagnostic capability. Fourfold  table  is used  with  the purpose to estimate the method which confirms or denies the diagnosis, i.e. a quality indicator. ROC-curve, being a graph, allows making the estimation of model  quality by subdivision of two classes  on the  basis  of identifying the  point  of cutting off a continuous or discrete quantitative attribute.The method of logistic regression technique is introduced as a tool to develop some  mathematical-statistical forecasting model  of probability of the event the researcher is interested in if there are two possible variants of the outcome. The method of ROC-analysis is chosen and described in detail as a tool to estimate the  model  quality. The capabilities of the named methods are demonstrated by a real example of creation  and  efficiency estimation (sensitivity and  specificity of a forecasting model  of probability of complication development in the form of pyodermatitis in children with  atopic dermatitis.

  3. Neutron activation analysis for environmental sample in Thailand

    International Nuclear Information System (INIS)

    Busamongkol, Arporn; Nouchpramool, Sunun; Bunprapob, Supamatthree; Sumitra, Tatchai

    2003-01-01

    Neutron Activation Analysis has been applied for the trace elements analysis in environmental samples. Thirty three samples of airborne particulate were collected every week at Ongkharak Nuclear Research Center (ONRC) during the period of June 1998 to March 1999. The Ti, I, Mg, Na, V, K, Cl, Al, Mn, Ca, As, Sm, Sb, Br, La, Ce, Th, Cr, Cs, Sc, Rb, Fe, Zn and Co were analyzed by Neutron Activation Analysis utilizing 2 MW TRIGA MARK III research reactor. The certified reference materials 1632a and 1633a from National Bureau of Standard were select as standard. (author)

  4. Use of graphite layer open tubular (GLOT) in environmental analysis

    International Nuclear Information System (INIS)

    Bruner, F.; Lattanzi, L.; Borghesi, P.

    1996-01-01

    Recently it has been developed a series of new capillary columns characterised by the use of graphitized carbon black modified from different amount of liquid phase. The characteristics of these columns, called graphite layer open tubular (GLOT), are described together with their application to the environmental analysis. A specific application of GLOT columns is for the direct analysis of aqueous solutions avoiding solvent extraction procedure. A comparison between a GLOT column and a traditional capillary column, estimating their behaviour after repeated direct injections of aqueous solution sample is written. Some applications regarding the analysis of the atmosphere pollutants, as aliphatic and aromatic hydrocarbons, and their compounds are written too

  5. Analysis of Environmental Law Enforcement Mechanism Based on Economic Principle

    Science.gov (United States)

    Cao, Hongjun; Shao, Haohao; Cai, Xuesen

    2017-11-01

    Strengthening and improving the environmental law enforcement mechanism is an important way to protect the ecological environment. This paper is based on economical principles, we did analysis of the marginal management costs by using Pigou means and the marginal transaction costs by using Coase means vary with the quantity growth of pollutant discharge Enterprises. We analyzed all this information, then we got the conclusion as follows. In the process of strengthening the environmental law enforcement mechanism, firstly, we should fully mobilize all aspects of environmental law enforcement, such as legislative bodies and law enforcement agencies, public welfare organizations, television, newspapers, enterprises, people and so on, they need to form a reasonable and organic structure system; then we should use various management means, such as government regulation, legal sanctions, fines, persuasion and denounce, they also need to form an organic structural system.

  6. Dual discounting in cost-benefit analysis for environmental impacts

    International Nuclear Information System (INIS)

    Kula, Erhun; Evans, David

    2011-01-01

    Discounting has been a long-established intertemporal efficiency tool in cost-benefit analysis which focuses on project selection at communal level with a view to maximising the social welfare. However, with the relentless growth in environmental stress that, in good parts, stems from investment projects the established criterion in discounting appears to be inadequate especially when environmental issues are taken into consideration. This paper looks at how dual focus on efficiency and sustainability can be achieved by using dual discounting, i.e. discounting environmental benefits separately and differently from other costs and benefits and applies this alternative criterion to an afforestation scheme in the United Kingdom which contains carbon sequestration in addition to timber benefits.

  7. Environmental accounting in Spain: structured review process and theoretical analysis

    Directory of Open Access Journals (Sweden)

    Fabricia Silva da Rosa

    2012-12-01

    Full Text Available One way to perceive and understand the level of development of environmental accounting is to study the main features of its publications. Thus, the purpose of this paper is to identify and analyze the profile of Spanish publications in accounting journals. To this end, 15 journals were selected and analyzed 74 articles in the period 2001 to 2010. The results show that the peak years of publication are 2001, 2003 and 2006, and authors with more articles in the sample are Moneva Abadía, Larrinaga González, Fernández Cuesta and Archel Domench. In terms of methodology, the works of review, case studies and content analysis, addressing standardization issues, fundamentals of environmental accounting, environmental sustainability indicators and reporting.

  8. Combining principles of Cognitive Load Theory and diagnostic error analysis for designing job aids: Effects on motivation and diagnostic performance in a process control task.

    Science.gov (United States)

    Kluge, Annette; Grauel, Britta; Burkolter, Dina

    2013-03-01

    Two studies are presented in which the design of a procedural aid and the impact of an additional decision aid for process control were assessed. In Study 1, a procedural aid was developed that avoids imposing unnecessary extraneous cognitive load on novices when controlling a complex technical system. This newly designed procedural aid positively affected germane load, attention, satisfaction, motivation, knowledge acquisition and diagnostic speed for novel faults. In Study 2, the effect of a decision aid for use before the procedural aid was investigated, which was developed based on an analysis of diagnostic errors committed in Study 1. Results showed that novices were able to diagnose both novel faults and practised faults, and were even faster at diagnosing novel faults. This research contributes to the question of how to optimally support novices in dealing with technical faults in process control. Copyright © 2012 Elsevier Ltd and The Ergonomics Society. All rights reserved.

  9. Energy analysis and environmental impacts of microalgal biodiesel in China

    International Nuclear Information System (INIS)

    Liao Yanfen; Huang Zehao; Ma Xiaoqian

    2012-01-01

    The entire life cycle of biodiesel produced by microalgal biomasses was evaluated using the method of life cycle assessment (LCA) to identify and quantify the fossil energy requirements and environmental impact loading of the system. The life cycle considers microalgae cultivation, harvesting, drying, oil extraction, anaerobic digestion, oil transportation, esterification, biodiesel transportation and biodiesel combustion. The investigation results show that the fossil energy requirement for the biodiesel production is 0.74 MJ/MJ biodiesel, indicating that 1 MJ of biodiesel requires an input of 0.74 MJ of fossil energy. Accordingly, biodiesel production is feasible as an energy producing process. The environmental impact loading of microalgal biodiesel is 3.69 PET 2010 (Person Equivalents, Targeted, in 2010) and the GWP is 0.16 kg CO 2-eq /MJ biodiesel. The effects of photochemical ozone formation were greatest among all calculated categorization impacts. The fossil energy requirement and GWP in this operation were found to be particularly sensitive to oil content, drying rate and esterification rate. Overall, the results presented herein indicate that the cultivation of microalgae has the potential to produce an environmentally sustainable feedstock for the production of biodiesel. - Highlights: ► Do energy analysis and environmental impacts of algal biodiesel in China. ► GWP and energy consumption are sensitive to lipid content and drying rate. ► Fossil energy consumption for algal biodiesel is 0.74 MJ/MJ. ► Microalgae are an environmentally sustainable feedstock for biodiesel production.

  10. Statistical Analysis of Environmental Tritium around Wolsong Site

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ju Youl [FNC Technology Co., Yongin (Korea, Republic of)

    2010-04-15

    To find the relationship among airborne tritium, tritium in rainwater, TFWT (Tissue Free Water Tritium) and TBT (Tissue Bound Tritium), statistical analysis is conducted based on tritium data measured at KHNP employees' house around Wolsong nuclear power plants during 10 years from 1999 to 2008. The results show that tritium in such media exhibits a strong seasonal and annual periodicity. Tritium concentration in rainwater is observed to be highly correlated with TFWT and directly transmitted to TFWT without delay. The response of environmental radioactivity of tritium around Wolsong site is analyzed using time-series technique and non-parametric trend analysis. Tritium in the atmosphere and rainwater is strongly auto-correlated by seasonal and annual periodicity. TFWT concentration in pine needle is proven to be more sensitive to rainfall phenomenon than other weather variables. Non-parametric trend analysis of TFWT concentration within pine needle shows a increasing slope in terms of confidence level of 95%. This study demonstrates a usefulness of time-series and trend analysis for the interpretation of environmental radioactivity relationship with various environmental media.

  11. Environmental costs and reverse logistics: a systemic analysis

    Directory of Open Access Journals (Sweden)

    Paula de Souza

    2013-08-01

    Full Text Available This article aims to analyze the articles most relevant to the themes inherent environmental costs from the perspective of reverse logistics, identifying gaps for these two approaches through systemic analysis. In order to achieve the purpose of this article, the intervention instrument used was ProKnow-C (Knowledge Process Development - Constructivist. The application of this methodology resulted in gross bank of articles, comprising 1225 items obtained from four international databases: Science Direct, ISI Web of Science, Scopus and Wiley Online Library. The raw bank was filtered in relation to redundancy, the alignment of the title and the scientific relevance. The filtering had resulted in a set of 15 articles aligned with two axes of research. The analysis of the selected articles identified the most cited article and the author most cited, concluding that the issue environmental costs associated with reverse logistics is studied by several authors and universities. Moreover, it was found that the keyword most presented in the articles was reverse logistics. The analysis of 1117 references of the 15 articles has shown the most cited articles, as well as the most countrast journals and academic relevance of authors and their selected articles. A systemic analysis of the 15 selected articles showed that the two lines of research are related mainly to issues of environmental sustainability, competitiveness and business efficiency.

  12. Cost-benefit analysis for design of environmentally conscious manufacturing

    International Nuclear Information System (INIS)

    Matysiak, L.M.

    1993-01-01

    In recent years, much attention has been focused on reducing the environmental impacts of products and manufacturing processes. Concerned about rising compliance costs and stringent regulatory requirements, companies are carefully evaluating the environmental impacts of their products. In response, designers, engineers, and managers are beginning to use life-cycle analysis, design for environment techniques, and environmentally conscious manufacturing (ECM) as tools to help them to not only do what is best for the environment, but also to do what is best for their company. These tools are also a useful aid in evaluating the trade-offs that may exist between different product and process alternatives. However, how does one choose the optimal solution from these various product and process alternatives? Cost versus benefit analysis is an effective tool that can be used to evaluate various manufacturing alternatives and to choose a solution that is both cost effective and environmentally compatible. Many companies are beginning to use cost benefit analyses as a means to justify product or process modifications that result in a benefit to the environment

  13. Systematic review and meta-analysis of the diagnostic accuracy of ultrasonography for deep vein thrombosis

    International Nuclear Information System (INIS)

    Goodacre, Steve; Sampson, Fiona; Thomas, Steve; Beek, Edwin van; Sutton, Alex

    2005-01-01

    Ultrasound (US) has largely replaced contrast venography as the definitive diagnostic test for deep vein thrombosis (DVT). We aimed to derive a definitive estimate of the diagnostic accuracy of US for clinically suspected DVT and identify study-level factors that might predict accuracy. We undertook a systematic review, meta-analysis and meta-regression of diagnostic cohort studies that compared US to contrast venography in patients with suspected DVT. We searched Medline, EMBASE, CINAHL, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Controlled Trials Register, Database of Reviews of Effectiveness, the ACP Journal Club, and citation lists (1966 to April 2004). Random effects meta-analysis was used to derive pooled estimates of sensitivity and specificity. Random effects meta-regression was used to identify study-level covariates that predicted diagnostic performance. We identified 100 cohorts comparing US to venography in patients with suspected DVT. Overall sensitivity for proximal DVT (95% confidence interval) was 94.2% (93.2 to 95.0), for distal DVT was 63.5% (59.8 to 67.0), and specificity was 93.8% (93.1 to 94.4). Duplex US had pooled sensitivity of 96.5% (95.1 to 97.6) for proximal DVT, 71.2% (64.6 to 77.2) for distal DVT and specificity of 94.0% (92.8 to 95.1). Triplex US had pooled sensitivity of 96.4% (94.4 to 97.1%) for proximal DVT, 75.2% (67.7 to 81.6) for distal DVT and specificity of 94.3% (92.5 to 95.8). Compression US alone had pooled sensitivity of 93.8 % (92.0 to 95.3%) for proximal DVT, 56.8% (49.0 to 66.4) for distal DVT and specificity of 97.8% (97.0 to 98.4). Sensitivity was higher in more recently published studies and in cohorts with higher prevalence of DVT and more proximal DVT, and was lower in cohorts that reported interpretation by a radiologist. Specificity was higher in cohorts that excluded patients with previous DVT. No studies were identified that compared repeat US to venography in all patients. Repeat US

  14. Diagnostic Performance of Narrow Band Imaging for Nasopharyngeal Cancer: A Systematic Review and Meta-analysis.

    Science.gov (United States)

    Sun, Changling; Zhang, Yayun; Han, Xue; Du, Xiaodong

    2018-03-01

    Objective The purposes of this study were to verify the effectiveness of the narrow band imaging (NBI) system in diagnosing nasopharyngeal cancer (NPC) as compared with white light endoscopy. Data Sources PubMed, Cochrane Library, EMBASE, CNKI, and Wan Fang databases. Review Methods Data analyses were performed with Meta-Disc. The updated Quality Assessment of Diagnostic Accuracy Studies-2 tool was used to assess study quality and potential bias. Publication bias was assessed with a Deeks asymmetry test. The registry number of the protocol published on PROSPERO is CRD42015026244. Results This meta-analysis included 10 studies of 1337 lesions. For NBI diagnosis of NPC, the pooled values were as follows: sensitivity, 0.83 (95% CI, 0.80-0.86); specificity, 0.91 (95% CI, 0.89-0.93); positive likelihood ratio, 8.82 (95% CI, 5.12-15.21); negative likelihood ratio, 0.18 (95% CI, 0.12-0.27); and diagnostic odds ratio, 65.73 (95% CI, 36.74-117.60). The area under the curve was 0.9549. For white light endoscopy in diagnosing NPC, the pooled values were as follows: sensitivity, 0.79 (95% CI, 0.75-0.83); specificity, 0.87 (95% CI, 0.84-0.90); positive likelihood ratio, 5.02 (95% CI, 1.99-12.65); negative likelihood ratio, 0.34 (95% CI, 0.24-0.49); and diagnostic odds ratio, 16.89 (95% CI, 5.98-47.66). The area under the curve was 0.8627. The evaluation of heterogeneity, calculated per the diagnostic odds ratio, gave an I 2 of 0.326. No marked publication bias ( P = .68) existed in this meta-analysis. Conclusion The sensitivity and specificity of NBI for the diagnosis of NPC are similar to those of white light endoscopy, and the potential value of NBI for the diagnosis of NPC needs to be validated further.

  15. Multi-complexity ensemble measures for gait time series analysis: application to diagnostics, monitoring and biometrics.

    Science.gov (United States)

    Gavrishchaka, Valeriy; Senyukova, Olga; Davis, Kristina

    2015-01-01

    Previously, we have proposed to use complementary complexity measures discovered by boosting-like ensemble learning for the enhancement of quantitative indicators dealing with necessarily short physiological time series. We have confirmed robustness of such multi-complexity measures for heart rate variability analysis with the emphasis on detection of emerging and intermittent cardiac abnormalities. Recently, we presented preliminary results suggesting that such ensemble-based approach could be also effective in discovering universal meta-indicators for early detection and convenient monitoring of neurological abnormalities using gait time series. Here, we argue and demonstrate that these multi-complexity ensemble measures for gait time series analysis could have significantly wider application scope ranging from diagnostics and early detection of physiological regime change to gait-based biometrics applications.

  16. Nuclear reactor pump diagnostics via noise analysis/artificial neural networks

    International Nuclear Information System (INIS)

    Keyvan, S.; Rabelo, L.C.

    1991-01-01

    A feasibility study is performed on the utilization of artificial neural networks as a tool for reactor diagnostics. Reactor pump signals utilized in a wear-out monitoring system developed for early detection of degradation of pump shaft are analyzed as a semi-benchmark test to study the feasibility of neural networks for pattern recognition. The Adaptive Resonance Theory (ART 2) paradigm of artificial neural networks is applied in this study. The signals are collected signals as well as generated signals simulating the wear progress. The wear-out monitoring system applies noise analysis techniques, and is capable of distinguishing between these signals and providing a measure of the progress of the degradation. This paper presents the results of the analysis of these data via the ART 2 paradigm

  17. Diagnostic and Prognostic Utility of Fluorescence In situ Hybridization (FISH) Analysis in Acute Myeloid Leukemia.

    Science.gov (United States)

    Gonzales, Patrick R; Mikhail, Fady M

    2017-12-01

    Acute myeloid leukemia (AML) is a hematologic neoplasia consisting of incompletely differentiated hematopoietic cells of the myeloid lineage that proliferate in the bone marrow, blood, and/or other tissues. Clinical implementation of fluorescence in situ hybridization (FISH) in cytogenetic laboratories allows for high-resolution analysis of recurrent structural chromosomal rearrangements specific to AML, especially in AML with normal karyotypes, which comprises approximately 33-50% of AML-positive specimens. Here, we review the use of several FISH probe strategies in the diagnosis of AML. We also review the standards and guidelines currently in place for use by clinical cytogenetic laboratories in the evaluation of AML. Updated standards and guidelines from the WHO, ACMG, and NCCN have further defined clinically significant, recurring cytogenetic anomalies in AML that are detectable by FISH. FISH continues to be a powerful technique in the diagnosis of AML, with higher resolution than conventional cytogenetic analysis, rapid turnaround time, and a considerable diagnostic and prognostic utility.

  18. Environmental analysis of Ribeiro wine from a timeline perspective: harvest year matters when reporting environmental impacts.

    Science.gov (United States)

    Vázquez-Rowe, Ian; Villanueva-Rey, Pedro; Moreira, Ma Teresa; Feijoo, Gumersindo

    2012-05-15

    A series of Galician (NW Spain) wines, such as Rías Baixas and Ribeiro have acquired international renown in the past few years. In this particular study, viticulture, vinification and bottling and packaging in a winery of the Ribeiro appellation were studied from a life cycle assessment perspective, with the main objective of identifying the largest environmental impacts for four different years of production (2007-2010). The selected functional unit was a 750 mL bottle of Ribeiro white wine, packaged for distribution. Inventory data was gathered mainly through direct communication using questionnaires. Results showed considerable annual variability in environmental performance, stressing the importance of including timeline analysis in the wine sector. Therefore, environmental scaling was proposed for the assessed wine based on the individual environmental impacts for each harvest year. Furthermore, the main hot spots identified were compost and pesticide production and emissions, in the agricultural phase and bottle production and electricity consumption, in the subsequent stages of wine production, in most of the selected impact categories. Suggested improvement opportunities included shifts in the compost transportation policy, recovery of natural resources for vineyard infrastructure, the introduction of new packaging formats in the bottling process and the use of pesticides with lower toxicity potential. Copyright © 2012 Elsevier Ltd. All rights reserved.

  19. Applying AI tools to operational space environmental analysis

    Science.gov (United States)

    Krajnak, Mike; Jesse, Lisa; Mucks, John

    1995-01-01

    The U.S. Air Force and National Oceanic Atmospheric Agency (NOAA) space environmental operations centers are facing increasingly complex challenges meeting the needs of their growing user community. These centers provide current space environmental information and short term forecasts of geomagnetic activity. Recent advances in modeling and data access have provided sophisticated tools for making accurate and timely forecasts, but have introduced new problems associated with handling and analyzing large quantities of complex data. AI (Artificial Intelligence) techniques have been considered as potential solutions to some of these problems. Fielding AI systems has proven more difficult than expected, in part because of operational constraints. Using systems which have been demonstrated successfully in the operational environment will provide a basis for a useful data fusion and analysis capability. Our approach uses a general purpose AI system already in operational use within the military intelligence community, called the Temporal Analysis System (TAS). TAS is an operational suite of tools supporting data processing, data visualization, historical analysis, situation assessment and predictive analysis. TAS includes expert system tools to analyze incoming events for indications of particular situations and predicts future activity. The expert system operates on a knowledge base of temporal patterns encoded using a knowledge representation called Temporal Transition Models (TTM's) and an event database maintained by the other TAS tools. The system also includes a robust knowledge acquisition and maintenance tool for creating TTM's using a graphical specification language. The ability to manipulate TTM's in a graphical format gives non-computer specialists an intuitive way of accessing and editing the knowledge base. To support space environmental analyses, we used TAS's ability to define domain specific event analysis abstractions. The prototype system defines

  20. Risk analysis and priority setting for environmental policy

    International Nuclear Information System (INIS)

    Travis, C.C.

    1991-01-01

    There is a growing realization that the demand for funding to correct our nation's environmental problems will soon outstrip available resources. In the hazardous waste area alone, the estimated cost of remediating Superfund sites ranges from $32 billion to $80 billion. Numerous other areas of competing for these same financial resources. These include ozone depletion, global warming, the protection of endangered species and wetlands, toxic air pollution, carcinogenic pesticides, and urban smog. In response to this imbalance in the supply and demand for national funds, several political constituencies are calling for the use of risk assessment as a tool in the prioritization of research and budget needs. Comparative risk analysis offers a logical framework in which to organize information about complex environmental problems. Risk analysis allows policy analysts to make resource allocation decisions on the basis of scientific judgement rather than political expediency

  1. Methods of I-129 analysis for environmental monitoring

    International Nuclear Information System (INIS)

    Nomura, T.; Katagiri, H.; Kitahara, Y.; Fukuda, S.

    1980-01-01

    Among the radioiodine isotopes discharged from nuclear facilities, I-129 has the longest half-life (1.7 x 10 7 years) and thus environmental monitoring of this nuclide is important. Methods of analysis of low level I-129 in environmental samples such as milk, crops, seaweeds and soils are described. The iodine is separated from the dried or pulverized samples by ignition at 1000 0 C in a quartz combustion apparatus with a stream of oxygen. Stable I-127 is simultaneously determined and the atom ratio of 129 I/ 127 I calculated in order to evaluate the thyroid dose by the specific activity method. Results of an analysis of typical food samples collected near the fuel reprocessing plant of Tokai Works showed no I-129 concentrations higher than the detection limit of the method (10 -2 pCi for 10 g. dry sample). (UK)

  2. Development of environmental education system using online element analysis

    International Nuclear Information System (INIS)

    Niizeki, T.; Yoshihara, T.; Tsuchiya, K.; Kawasaki, K.; Komiya, K.

    2007-01-01

    We have constructed a network system which enables one to access and analyze environmental data obtained at different and distant laboratories. As a preliminary feasibility test of the system, we studied the elements in the water of the Tesio River using PIXE and ion chromatography. Students used the data online to carry out analysis via internet. We found two factors with different features in calcium from the factor analysis. The comparison of the specific result and relevant geology information has revealed a remarkable presence of Ca 2+ which might come from dissolution of limestone in the upper Tesio River. PIXE data gave crucial information to draw such a conclusion. The present system has been found useful in environmental education in universities, online sharing of PIXE data in particular. (author)

  3. Geostatistical Analysis Methods for Estimation of Environmental Data Homogeneity

    Directory of Open Access Journals (Sweden)

    Aleksandr Danilov

    2018-01-01

    Full Text Available The methodology for assessing the spatial homogeneity of ecosystems with the possibility of subsequent zoning of territories in terms of the degree of disturbance of the environment is considered in the study. The degree of pollution of the water body was reconstructed on the basis of hydrochemical monitoring data and information on the level of the technogenic load in one year. As a result, the greatest environmental stress zones were isolated and correct zoning using geostatistical analysis techniques was proved. Mathematical algorithm computing system was implemented in an object-oriented programming C #. A software application has been obtained that allows quickly assessing the scale and spatial localization of pollution during the initial analysis of the environmental situation.

  4. Development of Multi-perspective Diagnostics and Analysis Algorithms with Applications to Subsonic and Supersonic Combustors

    Science.gov (United States)

    Wickersham, Andrew Joseph

    There are two critical research needs for the study of hydrocarbon combustion in high speed flows: 1) combustion diagnostics with adequate temporal and spatial resolution, and 2) mathematical techniques that can extract key information from large datasets. The goal of this work is to address these needs, respectively, by the use of high speed and multi-perspective chemiluminescence and advanced mathematical algorithms. To obtain the measurements, this work explored the application of high speed chemiluminescence diagnostics and the use of fiber-based endoscopes (FBEs) for non-intrusive and multi-perspective chemiluminescence imaging up to 20 kHz. Non-intrusive and full-field imaging measurements provide a wealth of information for model validation and design optimization of propulsion systems. However, it is challenging to obtain such measurements due to various implementation difficulties such as optical access, thermal management, and equipment cost. This work therefore explores the application of FBEs for non-intrusive imaging to supersonic propulsion systems. The FBEs used in this work are demonstrated to overcome many of the aforementioned difficulties and provided datasets from multiple angular positions up to 20 kHz in a supersonic combustor. The combustor operated on ethylene fuel at Mach 2 with an inlet stagnation temperature and pressure of approximately 640 degrees Fahrenheit and 70 psia, respectively. The imaging measurements were obtained from eight perspectives simultaneously, providing full-field datasets under such flow conditions for the first time, allowing the possibility of inferring multi-dimensional measurements. Due to the high speed and multi-perspective nature, such new diagnostic capability generates a large volume of data and calls for analysis algorithms that can process the data and extract key physics effectively. To extract the key combustion dynamics from the measurements, three mathematical methods were investigated in this work

  5. Diagnostic value of MR analysis of cartilaginous lesions compared with intraoperative arthroscopy in calcaneal fractures

    International Nuclear Information System (INIS)

    Schroeder, R.J.; Nekwasil, S.J.; Felix, R.; Hidajat, N.; Boack, D.H.; Haas, N.P.; Martus, P.

    2005-01-01

    Purpose: To determine the diagnostic value of MRI in preoperative analysis and classification of cartilaginous lesions - especially of the posterior facet - in traumatic calcaneal fractures compared with intraoperative arthroscopy. Materials and Methods: Twenty-four consecutive patients with traumatic calcaneal fractures underwent prospective MRI of the subtalar joint surface using T1- and T2-weighted spin echo sequences and fat suppressed 3D gradient echo sequences in semicoronal slice orientation (1.5 T MRI). After randomization, the images were analyzed by two blinded and independent readers experienced in MRI. The results were compared with the intraoperative arthroscopic findings as to location and depth of the defects using the Outerbridge classification. Results: We examined 12 calcaneal fractures of type 2, 8 of type 3 and 4 of type 4 according to the Sanders classification. With respect to principal detection and exact classification, 67 to 96 (69.8%) of all arthroscopic verified cartilaginous defects were diagnosed correctly by MRI. Disregarding the degree of the defects, 38 of 44 (86.4%) chondral lesions were detected (sensitivity: 86.4%, specificity: 86.5%, diagnostic accuracy: 86.5%). Considering the chondral lesions of degrees 3 and 4 together, the sensitivity was 86.0%, the specificity 86.8%, and the diagnostic accuracy 86.5%. Assessing these degrees separately, the sensitivity was only 33.3% for degree 3 and 58.1% for degree 4, whereas the specificity was definitely higher with 82.1% for degree 3 and 89.2% for degree 4. (orig.)

  6. ADAM: An Accident Diagnostic,Analysis and Management System - Applications to Severe Accident Simulation and Management

    International Nuclear Information System (INIS)

    Zavisca, M.J.; Khatib-Rahbar, M.; Esmaili, H.; Schulz, R.

    2002-01-01

    The Accident Diagnostic, Analysis and Management (ADAM) computer code has been developed as a tool for on-line applications to accident diagnostics, simulation, management and training. ADAM's severe accident simulation capabilities incorporate a balance of mechanistic, phenomenologically based models with simple parametric approaches for elements including (but not limited to) thermal hydraulics; heat transfer; fuel heatup, meltdown, and relocation; fission product release and transport; combustible gas generation and combustion; and core-concrete interaction. The overall model is defined by a relatively coarse spatial nodalization of the reactor coolant and containment systems and is advanced explicitly in time. The result is to enable much faster than real time (i.e., 100 to 1000 times faster than real time on a personal computer) applications to on-line investigations and/or accident management training. Other features of the simulation module include provision for activation of water injection, including the Engineered Safety Features, as well as other mechanisms for the assessment of accident management and recovery strategies and the evaluation of PSA success criteria. The accident diagnostics module of ADAM uses on-line access to selected plant parameters (as measured by plant sensors) to compute the thermodynamic state of the plant, and to predict various margins to safety (e.g., times to pressure vessel saturation and steam generator dryout). Rule-based logic is employed to classify the measured data as belonging to one of a number of likely scenarios based on symptoms, and a number of 'alarms' are generated to signal the state of the reactor and containment. This paper will address the features and limitations of ADAM with particular focus on accident simulation and management. (authors)

  7. A Meta-Analysis of the Diagnostic Accuracy of Circular RNAs in Digestive System Malignancy.

    Science.gov (United States)

    Chen, Zhiqiang; Zhang, Long; Han, Guoyong; Zuo, Xueliang; Zhang, Yao; Zhu, Qin; Wu, Jindao; Wang, Xuehao

    2018-01-01

    Circular RNAs (circRNAs), a novel class of noncoding RNAs, have been found to be dysregulated in various cancers. However, the clinical application value of these circRNAs in digestive system cancers remains to be clarified. We aimed to comprehensively explore the potential role of circRNAs as diagnostic indicators in digestive system malignancies. Relevant studies were systematically retrieved from PubMed, Web of Science and the Cochrane Library. The data that were required to complete 2 × 2 contingency tables were obtained from the included studies. Stratified analyses by cancer type, sample size and publication year were performed. Thirteen studies with 2,276 individuals were included in the meta-analysis. The pooled sensitivity and specificity of circRNAs in the diagnosis of digestive system malignancy were 0.72 [95% confidence interval (CI): 0.65-0.77] and 0.77 (95% CI: 0.72-0.81), respectively. The overall positive likelihood ratio was 3.09 (95% CI: 2.64-3.62), and the overall negative likelihood ratio was 0.37 (95% CI: 0.31-0.44). The pooled diagnostic odds ratio was 8.38 (95% CI: 6.86-10.25), and the overall area under the curve was 0.81 (95% CI: 0.77-0.84), indicating good discriminative ability of circRNAs as biomarkers for digestive system malignancy. circRNAs distinguish patients with digestive system cancer from controls with relatively high diagnostic accuracy. circRNAs may be used as potential biomarkers for the diagnosis of digestive system malignancy. © 2018 The Author(s). Published by S. Karger AG, Basel.

  8. Diagnostic accuracy of fluorine-18-fluorodeoxyglucose positron emission tomography in gallbladder cancer: A meta-analysis.

    Science.gov (United States)

    Annunziata, Salvatore; Pizzuto, Daniele Antonio; Caldarella, Carmelo; Galiandro, Federica; Sadeghi, Ramin; Treglia, Giorgio

    2015-10-28

    To meta-analyze published data about the diagnostic accuracy of fluorine-18-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET) and PET/computed tomography (PET/CT) in the evaluation of primary tumor in patients with gallbladder cancer (GBCa). A comprehensive literature search of studies published through 30(th) June 2014 regarding the role of (18)F-FDG PET and PET/CT in the evaluation of primary gallbladder cancer (GBCa) was performed. All retrieved studies were reviewed. Pooled sensitivity and specificity of (18)F-FDG PET or PET/CT in the evaluation of primary GBCa were calculated. The area under the summary receiving operator characteristics curve (AUC) was calculated to measure the accuracy of these methods. Sub-analyses considering the device used (PET vs PET/CT) were carried out. Twenty-one studies comprising 495 patients who underwent (18)F-FDG PET or PET/CT for suspicious GBCa were selected for the systematic review. The meta-analysis of 13 selected studies provided the following results: sensitivity 87% (95%CI: 82%-92%), specificity 78% (95%CI: 68%-86%). The AUC was 0.88. Improvement of sensitivity and specificity was observed when PET/CT was used. (18)F-FDG-PET and PET/CT demonstrated to be useful diagnostic imaging methods in the assessment of primary tumor in GBCa patients, nevertheless possible sources of false-negative and false-positive results should be kept in mind. PET/CT seems to have a better diagnostic accuracy than PET alone in this setting.

  9. Analysis of documentary support for environmental restoration programs in Russia

    International Nuclear Information System (INIS)

    Nechaev, A.F.; Projaev, V.V.

    1995-01-01

    Taking into account an importance of an adequate regulations for ensuring of radiological safety of the biosphere and for successful implementation of environmental restoration projects, contents of legislative and methodical documents as well as their comprehensitivity and substantiation are subjected to critical analysis. It is shown that there is much scope for further optimization of and improvements in regulatory basis both on Federal and regional levels

  10. Instrumental neutron activation analysis in environmental studies of trace elements

    International Nuclear Information System (INIS)

    Salmon, L.

    1975-06-01

    The application of a routine instrumental nuclear method is described in relation to environmental surveys and studies. A working rather than formal review is made of the techniques applied with particular reference to the data processing methods involved. The elements measured by instrumental activation analysis were: Ag, Al, As, Au, Ba, Br, Ca, Ce, Cl, Cd, Co, Cr, Cs, Cu, Fe, Hg, I, In, La, Mn, Na, Ni, Pb, Rb, Sb, Sc, Se, Th, Ti, U, V, W, Zn. (author)

  11. Diagnostic imaging for chronic plantar heel pain: a systematic review and meta-analysis

    Science.gov (United States)

    2009-01-01

    Background Chronic plantar heel pain (CPHP) is a generalised term used to describe a range of undifferentiated conditions affecting the plantar heel. Plantar fasciitis is reported as the most common cause and the terms are frequently used interchangeably in the literature. Diagnostic imaging has been used by many researchers and practitioners to investigate the involvement of specific anatomical structures in CPHP. These observations help to explain the underlying pathology of the disorder, and are of benefit in forming an accurate diagnosis and targeted treatment plan. The purpose of this systematic review was to investigate the diagnostic imaging features associated with CPHP, and evaluate study findings by meta-analysis where appropriate. Methods Bibliographic databases including Medline, Embase, CINAHL, SportDiscus and The Cochrane Library were searched electronically on March 25, 2009. Eligible articles were required to report imaging findings in participants with CPHP unrelated to inflammatory arthritis, and to compare these findings with a control group. Methodological quality was evaluated by use of the Quality Index as described by Downs and Black. Meta-analysis of study data was conducted where appropriate. Results Plantar fascia thickness as measured by ultrasonography was the most widely reported imaging feature. Meta-analysis revealed that the plantar fascia of CPHP participants was 2.16 mm thicker than control participants (95% CI = 1.60 to 2.71 mm, P plantar fascia thickness values greater than 4.0 mm (OR = 105.11, 95% CI = 3.09 to 3577.28, P = 0.01). CPHP participants were also more likely to show radiographic evidence of subcalcaneal spur than control participants (OR = 8.52, 95% CI = 4.08 to 17.77, P plantar fascia and inferior calcaneum in people with CPHP. Analysis of these studies found that people with CPHP are likely to have a thickened plantar fascia with associated fluid collection, and that thickness values >4.0 mm are diagnostic of

  12. Use of the environmental resource management and analysis system at the Fernald Environmental Management Project

    International Nuclear Information System (INIS)

    Erjavec, J.L.

    1992-01-01

    In the past, hazardous waste site characterization and remediation using computer-based technologies has been a difficult and time-consuming process because of the need to analyze data using non-interfaced computer and software environments. The Environmental Resource Management and Analysis System (ERMA) was developed as an innovative approach to the management, analyses and depiction of data collected during a hazardous site remediation. A modular, multi-disciplined software package, ERMA integrates an environmental database management system with variety of Geographic Information System technologies. ERMA capabilities include spatial analysis, three-dimensional subsurface geologic interpretation and modeling, terrain modeling, and groundwater flow and contaminant transport modeling. ERMA's data management is provided through a set of user-modifiable, graphic interface tools that permit complex data queries, data modification and reporting. An ERMA prototype has been implemented at the Fernald Environmental Management Project (a Department of Energy cleanup site) using groundwater monitoring and elevation data collected over the last few years. ERMA has enabled the precision posting of data from the 853 groundwater monitoring wells at the site. Data from these wells have ben used to define the piezometric surface of the Great Miami Aquifer and correlate it with the uranium concentration contours of an identified groundwater plume. Using spatial query capabilities, radioactive sampling results from monitoring wells have been compared to contour maps defining the extent of the plume to determine the validity of those maps and the need for additional well locations

  13. Transuranium analysis methodologies for biological and environmental samples

    International Nuclear Information System (INIS)

    Wessman, R.A.; Lee, K.D.; Curry, B.; Leventhal, L.

    1978-01-01

    Analytical procedures for the most abundant transuranium nuclides in the environment (i.e., plutonium and, to a lesser extent, americium) are available. There is a lack of procedures for doing sequential analysis for Np, Pu, Am, and Cm in environmental samples, primarily because of current emphasis on Pu and Am. Reprocessing requirements and waste disposal connected with the fuel cycle indicate that neptunium and curium must be considered in environmental radioactive assessments. Therefore it was necessary to develop procedures that determine all four of these radionuclides in the environment. The state of the art of transuranium analysis methodology as applied to environmental samples is discussed relative to different sample sources, such as soil, vegetation, air, water, and animals. Isotope-dilution analysis with 243 Am ( 239 Np) and 236 Pu or 242 Pu radionuclide tracers is used. Americium and curium are analyzed as a group, with 243 Am as the tracer. Sequential extraction procedures employing bis(2-ethyl-hexyl)orthophosphoric acid (HDEHP) were found to result in lower yields and higher Am--Cm fractionation than ion-exchange methods

  14. Clinical diagnostic evaluation for scaphoid fractures: a systematic review and meta-analysis

    NARCIS (Netherlands)

    Mallee, Wouter H.; Henny, Erik P.; van Dijk, C. Niek; Kamminga, Sjoerd P.; van Enst, Wynanda A.; Kloen, Peter

    2014-01-01

    To provide an overview of available clinical evaluation tests for scaphoid fractures and to compare their diagnostic accuracies. PWe performed a systematic review of all studies assessing diagnostic characteristics of clinical evaluation in scaphoid fractures by searching MEDLINE, EMBASE, Cochrane,

  15. Analysis of errors during medical and computerized diagnostics of spherical lung neoplasms

    International Nuclear Information System (INIS)

    Pozmogov, A.I.; Petruk, D.A.

    1985-01-01

    Reasons for errors in medical and computerized diagnostics of spherical lung neoplasms are studied based on material of 212 case records and clinicoroentgenological data; it should promote improvement of their diagnostics

  16. Application of X-ray fluorescence analysis in environmental research

    International Nuclear Information System (INIS)

    Kliment, V.; Kliman, J.; Turzo, I.

    1978-01-01

    A description is presented of the X-ray fluorescence analysis principles and of its possibilities in the study of environmental pollution impact. Experiments with X-ray fluorescence analysis using 241-Am and a Ge(Li) semiconductor detector are discussed. The reproducibility of determinations in dependence on the sample preparation and the evaluation of peak surfaces of characteristic radiation is shown. The dependence of the peak surface on the elemental contents in the sample was linear. Detection limits of the investigated elements ranged in tenths of μg for 300 s measurement. (author)

  17. Environmental impact analysis for the main accidental sequences of ignitor

    International Nuclear Information System (INIS)

    Carpignano, A.; Francabandiera, S.; Vella, R.; Zucchetti, M.

    1996-01-01

    A safety analysis study has been applied to the Ignitor machine using Probabilistic Safety Assessment. The main initiating events have been identified, and accident sequences have been studied by means of traditional methods such as Failure Mode and Effect Analysis (FMEA), Fault Trees (FT) and Event Trees (ET). The consequences of the radioactive environmental releases have been assessed in terms of Effective Dose Equivalent (EDEs) to the Most Exposed Individuals (MEI) of the chosen site, by means of a population dose code. Results point out the low enviromental impact of the machine. 13 refs., 1 fig., 3 tabs

  18. A Meta-analysis for the Diagnostic Performance of Transient Elastography for Clinically Significant Portal Hypertension.

    Science.gov (United States)

    You, Myung-Won; Kim, Kyung Won; Pyo, Junhee; Huh, Jimi; Kim, Hyoung Jung; Lee, So Jung; Park, Seong Ho

    2017-01-01

    We aimed to evaluate the correlation between liver stiffness measurement using transient elastography (TE-LSM) and hepatic venous pressure gradient and the diagnostic performance of TE-LSM in assessing clinically significant portal hypertension through meta-analysis. Eleven studies were included from thorough literature research and selection processes. The summary correlation coefficient was 0.783 (95% confidence interval [CI], 0.737-0.823). Summary sensitivity, specificity and area under the hierarchical summary receiver operating characteristic curve (AUC) were 87.5% (95% CI, 75.8-93.9%), 85.3 % (95% CI, 76.9-90.9%) and 0.9, respectively. The subgroup with low cut-off values of 13.6-18 kPa had better summary estimates (sensitivity 91.2%, specificity 81.3% and partial AUC 0.921) than the subgroup with high cut-off values of 21-25 kPa (sensitivity 71.2%, specificity 90.9% and partial AUC 0.769). In summary, TE-LSM correlated well with hepatic venous pressure gradient and represented good diagnostic performance in diagnosing clinically significant portal hypertension. For use as a sensitive screening tool, we propose using low cut-off values of 13.6-18 kPa in TE-LSM. Copyright © 2016 World Federation for Ultrasound in Medicine & Biology. Published by Elsevier Inc. All rights reserved.

  19. A study on the fault diagnostic techniques for reactor internal structures using neutron noise analysis

    International Nuclear Information System (INIS)

    Kim, Tae Ryong; Jeong, Seong Ho; Park, Jin Ho; Park, Jin Suk

    1994-08-01

    The unfavorable phenomena, such as flow induced vibration and aging process in reactor internals, cause degradation of structural integrity and may result in loosing some mechanical binding components which might impact other equipments and components or cause flow blockage. Since these malfunctions and potential failures change reactor noise signal, it is necessary to analyze reactor noise signal for early fault diagnosis in the point of few of safety and plant economics. The objectives of this study are to establish fault diagnostic and TS(thermal shield), and to develop a data acquisition and signal processing software system. In the first year of this study, an analysis technique for the reactor internal vibration using the reactor noise was proposed. With the technique proposed and the reactor noise signals (ex-core neutron and acceleration), the dynamic characteristics of Ulchin-1 reactor internals were obtained, and compared with those of Tricastin-1 which is the prototype of Ulchin-1. In the second year, a PC-based expert system for reactor internals fault diagnosis is developed, which included data acquisition, signal processing, feature extraction function, and represented diagnostic knowledge by the IF-THEN rule. To know the effect of the faults, the reactor internals of Ulchin-1 is modeled using FEM and simulated with an artificial defect given in the hold-down spring. Trend in the dynamic characteristics of reactor internals is also observed during one fuel cycle to know the effect of boron concentration. 100 figs, 7 tabs, 18 refs. (Author)

  20. Measuring diagnostic and predictive accuracy in disease management: an introduction to receiver operating characteristic (ROC) analysis.

    Science.gov (United States)

    Linden, Ariel

    2006-04-01

    Diagnostic or predictive accuracy concerns are common in all phases of a disease management (DM) programme, and ultimately play an influential role in the assessment of programme effectiveness. Areas, such as the identification of diseased patients, predictive modelling of future health status and costs and risk stratification, are just a few of the domains in which assessment of accuracy is beneficial, if not critical. The most commonly used analytical model for this purpose is the standard 2 x 2 table method in which sensitivity and specificity are calculated. However, there are several limitations to this approach, including the reliance on a single defined criterion or cut-off for determining a true-positive result, use of non-standardized measurement instruments and sensitivity to outcome prevalence. This paper introduces the receiver operator characteristic (ROC) analysis as a more appropriate and useful technique for assessing diagnostic and predictive accuracy in DM. Its advantages include; testing accuracy across the entire range of scores and thereby not requiring a predetermined cut-off point, easily examined visual and statistical comparisons across tests or scores, and independence from outcome prevalence. Therefore the implementation of ROC as an evaluation tool should be strongly considered in the various phases of a DM programme.

  1. Searching for New Biomarkers and the Use of Multivariate Analysis in Gastric Cancer Diagnostics.

    Science.gov (United States)

    Kucera, Radek; Smid, David; Topolcan, Ondrej; Karlikova, Marie; Fiala, Ondrej; Slouka, David; Skalicky, Tomas; Treska, Vladislav; Kulda, Vlastimil; Simanek, Vaclav; Safanda, Martin; Pesta, Martin

    2016-04-01

    The first aim of this study was to search for new biomarkers to be used in gastric cancer diagnostics. The second aim was to verify the findings presented in literature on a sample of the local population and investigate the risk of gastric cancer in that population using a multivariant statistical analysis. We assessed a group of 36 patients with gastric cancer and 69 healthy individuals. We determined carcinoembryonic antigen, cancer antigen 19-9, cancer antigen 72-4, matrix metalloproteinases (-1, -2, -7, -8 and -9), osteoprotegerin, osteopontin, prothrombin induced by vitamin K absence-II, pepsinogen I, pepsinogen II, gastrin and Helicobacter pylori for each sample. The multivariate stepwise logistic regression identified the following biomarkers as the best gastric cancer predictors: CEA, CA72-4, pepsinogen I, Helicobacter pylori presence and MMP7. CEA and CA72-4 remain the best markers for gastric cancer diagnostics. We suggest a mathematical model for the assessment of risk of gastric cancer. Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

  2. Strategies for the implementation of an environmental mining plan of the construction materials in Bogota. Phase 1 Diagnostic

    International Nuclear Information System (INIS)

    Gonzalez Oviedo, Leopoldo; Parrado L, Guillermo; Cardenas, John Fernan

    1995-01-01

    The study contains the geologic aspects, miners and environmental of 10 areas selected in Bogota where construction materials exist, like they are sands, clays, and gravels, in each area a definition is made, the productive units are described, reserves, mining production and environmental impacts are given generated by the material exploitation; a prioritizing of potential areas is included to implement a miner-environmental plan of this industry in Bogota

  3. Diagnostic performance of computed tomography for parathyroid adenoma localization; a systematic review and meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kluijfhout, Wouter P., E-mail: WPKluijfhout@gmail.com [Department of Surgery, University of California San Francisco (United States); Department of Surgery, University Medical Center Utrecht (Netherlands); Pasternak, Jesse D. [Department of Surgery, University Health Network Toronto (Canada); Beninato, Toni; Drake, Frederick Thurston; Gosnell, Jessica E.; Shen, Wen T.; Duh, Quan-Yang [Department of Surgery, University of California San Francisco (United States); Allen, Isabel E. [Department of Epidemiology and Biostatistics, University of California San Francisco (United States); Vriens, Menno R. [Department of Surgery, University Medical Center Utrecht (Netherlands); Keizer, Bart de [Department of Radiology, University Medical Center Utrecht (Netherlands); Hope, Thomas A. [Department of Radiology, University of California San Francisco (United States); Suh, Insoo [Department of Surgery, University of California San Francisco (United States)

    2017-03-15

    Highlights: • CT performs well in localizing pathological parathyroid glands. • Performance of CT is less in patients with inconclusive ultrasound and sestamibi. • Addition of a third contrast phase seems to have little added value. - Abstract: Abstract purpose: To perform a systematic review and meta-analysis of the sensitivity and positive predictive value (PPV) of CT for preoperative parathyroid localization in patients with primary hyperparathyroidism (pHPT), and subsequently compare the different protocols and their performance in different patient groups. Materials and methods: We performed a search of the Embase, Pubmed and Cochrane Library databases to identify studies published between January 1, 2000 and March 31, 2016 investigating the diagnostic value of CT for parathyroid localization in patients with biochemical diagnosis of pHPT. Performance of CT was expressed in sensitivity and PPV with pooled proportion using a random-effects model. Factors that could have affected the diagnostic performance were investigated by subgroup analysis. Results: Thirty-four studies evaluating a total of 2563 patients with non-familial pHPT who underwent CT localization and surgical resection were included. Overall pooled sensitivity of CT for localization of the pathological parathyroid(s) to the correct quadrant was 73% (95% CI: 69–78%), which increased to 81% (95% CI: 75–87%) for lateralization to the correct side. Subgroup analysis based on the number of contrast phases showed that adding a second contrast phase raises sensitivity from 71% (95% CI: 61–80%) to 76% (95% CI: 71–87%), and that adding a third phase resulted in a more modest additional increase in performance with a sensitivity of 80% (95% CI: 74–86%). Conclusion: CT performs well in localizing pathological glands in patients with pHPT. A protocol with two contrast phases seems to offer a good balance of acceptable performance with limitation of radiation exposure.

  4. An optimum analysis sequence for environmental gamma-ray spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    De la Torre, F.; Rios M, C.; Ruvalcaba A, M. G.; Mireles G, F.; Saucedo A, S.; Davila R, I.; Pinedo, J. L., E-mail: fta777@hotmail.co [Universidad Autonoma de Zacatecas, Centro Regional de Estudis Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)

    2010-10-15

    This work aims to obtain an optimum analysis sequence for environmental gamma-ray spectroscopy by means of Genie 2000 (Canberra). Twenty different analysis sequences were customized using different peak area percentages and different algorithms for: 1) peak finding, and 2) peak area determination, and with or without the use of a library -based on evaluated nuclear data- of common gamma-ray emitters in environmental samples. The use of an optimum analysis sequence with certified nuclear information avoids the problems originated by the significant variations in out-of-date nuclear parameters of commercial software libraries. Interference-free gamma ray energies with absolute emission probabilities greater than 3.75% were included in the customized library. The gamma-ray spectroscopy system (based on a Ge Re-3522 Canberra detector) was calibrated both in energy and shape by means of the IAEA-2002 reference spectra for software intercomparison. To test the performance of the analysis sequences, the IAEA-2002 reference spectrum was used. The z-score and the reduced {chi}{sup 2} criteria were used to determine the optimum analysis sequence. The results show an appreciable variation in the peak area determinations and their corresponding uncertainties. Particularly, the combination of second derivative peak locate with simple peak area integration algorithms provides the greater accuracy. Lower accuracy comes from the combination of library directed peak locate algorithm and Genie's Gamma-M peak area determination. (Author)

  5. An optimum analysis sequence for environmental gamma-ray spectrometry

    International Nuclear Information System (INIS)

    De la Torre, F.; Rios M, C.; Ruvalcaba A, M. G.; Mireles G, F.; Saucedo A, S.; Davila R, I.; Pinedo, J. L.

    2010-10-01

    This work aims to obtain an optimum analysis sequence for environmental gamma-ray spectroscopy by means of Genie 2000 (Canberra). Twenty different analysis sequences were customized using different peak area percentages and different algorithms for: 1) peak finding, and 2) peak area determination, and with or without the use of a library -based on evaluated nuclear data- of common gamma-ray emitters in environmental samples. The use of an optimum analysis sequence with certified nuclear information avoids the problems originated by the significant variations in out-of-date nuclear parameters of commercial software libraries. Interference-free gamma ray energies with absolute emission probabilities greater than 3.75% were included in the customized library. The gamma-ray spectroscopy system (based on a Ge Re-3522 Canberra detector) was calibrated both in energy and shape by means of the IAEA-2002 reference spectra for software intercomparison. To test the performance of the analysis sequences, the IAEA-2002 reference spectrum was used. The z-score and the reduced χ 2 criteria were used to determine the optimum analysis sequence. The results show an appreciable variation in the peak area determinations and their corresponding uncertainties. Particularly, the combination of second derivative peak locate with simple peak area integration algorithms provides the greater accuracy. Lower accuracy comes from the combination of library directed peak locate algorithm and Genie's Gamma-M peak area determination. (Author)

  6. Assessment Stability and Informative of Diagnostic Matrix in Analysis States of Reinforced Concrete Slab

    Directory of Open Access Journals (Sweden)

    Sokolov Vladimir

    2016-01-01

    Full Text Available In this article was examined the issues of sustainability and informative of diagnostic matrix, which are used when it is necessary to determinate the technical condition of constructions. Determination based on the mathematical instrument of technical diagnostics. One of the most widespread methods of technical diagnostics – a statistical method of Bayes is used.

  7. Analysis of environmental impact assessment (EIA) system in Turkey.

    Science.gov (United States)

    Coşkun, Aynur Aydın; Turker, Ozhan

    2011-04-01

    The Environmental Impact Assessment (EIA) System, which embodies the "prevention principle" of the environmental law, is an important tool for environmental protection. This tool has a private importance for Turkey since it is a developing country, and it entered the Turkish law in 1983 with the Environmental Law. Besides, the EIA Regulation, which shows the application principles, became effective in 1993. Because Turkey is a candidate for European Union (EU), the EIA Regulation has been changed due to the EU compliance procedure, and its latest version became valid in 2008. This study aims to emphasize The EIA system in Turkey to supervise the efficiency of this procedure and point the success level. In the introduction part, general EIA concept, its importance, and some notations are mentioned. Following that, the legislation, which builds the EIA system, has been analyzed starting from the 1982 Turkish Constitution. Then, the legislation rules are explained due to the basic steps of the EIA procedure. In order to shed light upon the application, the EIA final decisions given until today, the results, and their distributions to the industries are assessed. In the final part of the study, a SWOT analysis is made to mention the weaknesses, strengths, opportunities, and threats of the EIA system in Turkey.

  8. ANALYSIS OF THE PUBLIC MANAGEMENT ADMINISTRATION IN ROMANIA BASED ON DIAGNOSTICS AND SWOT ANALYSIS

    OpenAIRE

    ANCA JARMILA GUŢĂ

    2015-01-01

    The paper identifies the strengths and weaknesses points existing in a public organization at the five management functions : planning, organization, coordination, training and control. It also done a PEST analysis of public management in Romania and it proposes a global model diagnosis and SWOT analysis for a public service.

  9. ANALYSIS OF THE PUBLIC MANAGEMENT ADMINISTRATION IN ROMANIA BASED ON DIAGNOSTICS AND SWOT ANALYSIS

    Directory of Open Access Journals (Sweden)

    ANCA JARMILA GUŢĂ

    2015-10-01

    Full Text Available The paper identifies the strengths and weaknesses points existing in a public organization at the five management functions : planning, organization, coordination, training and control. It also done a PEST analysis of public management in Romania and it proposes a global model diagnosis and SWOT analysis for a public service.

  10. CAPITAL STRUCTURE ANALYSIS OF THE MEDICAL DIAGNOSTIC-CONSULTATIVE CENTERS IN VARNA (absolute indicators

    Directory of Open Access Journals (Sweden)

    Lyubomira Koeva-Dimitrova

    2016-08-01

    Full Text Available The capital structure analysis of medical institutions is related to the assessment of their financial sustainability. The degree of their financial sustainability indicates the extent to which the medical institution is exposed to financial risk. This financial risk is related to the use of foreign capital (debts, loans, etc. and it is defined as the probability of insolvency and possible bankruptcy due to the existence of debts which could not be repaid at some point in the foreseeable future. Objective: To analyze the capital structure of the medical diagnostic-consultative centers in Varna city and on this basis to assess their long-term solvency and existence of financial risk. Materials and Methods: The materials for the study are the published annual financial statements (up to 05. 01. 2016 in the Commercial Register for the period from year 2008 to 2014 of all MDCCs (Medical Diagnostic Consultative centers, registered in Varna - 9 in total. In the study are applied logical-mathematical methods (comparison, grouping, detail, graphical method; financial and accounting analysis (balance sheet analysis; analysis of absolute ratios for financial sustainability. Results: Upon analysis of the capital structure of MDCC's are studied the main absolute indicators characterizing the conditions for financial sustainability and the existence of financial risk regarding the solvency. A table represents the overall assessment of the degree of financial sustainability of the companies according to the type and structure of the fulfilled criteria. It was ascertained that for year 2014, DCC 3, 4, 5 and 8 have met all the conditions and according to them these hospitals have very high financial sustainability. DCC 7 has an average financial sustainability, DCC 1 and 2 are in a financial crisis and DCC 6 and 9 are facing bankruptcy. It must be emphasized that nearly half of the studied health care organizations (DCC 1, 2, 6 and 9 need urgent intervention by

  11. Analysis of polychlorinated n-alkanes in environmental samples.

    Science.gov (United States)

    Santos, F J; Parera, J; Galceran, M T

    2006-10-01

    Polychlorinated n-alkanes (PCAs), also known as chlorinated paraffins (CPs), are highly complex technical mixtures that contain a huge number of structural isomers, theoretically more than 10,000 diastereomers and enantiomers. As a consequence of their persistence, tendency to bioaccumulation, and widespread and unrestricted use, PCAs have been found in aquatic and terrestrial food webs, even in rural and remote areas. Recently, these compounds have been included in regulatory programs of several international organizations, including the US Environmental Protection Agency and the European Union. Consequently, there is a growing demand for reliable methods with which to analyze PCAs in environmental samples. Here, we review current trends and recent developments in the analysis of PCAs in environmental samples such as air, water, sediment, and biota. Practical aspects of sample preparation, chromatographic separation, and detection are covered, with special emphasis placed on analysis of PCAs using gas chromatography-mass spectrometry. The advantages and limitations of these techniques as well as recent improvements in quantification procedures are discussed.

  12. 32 CFR 989.12 - AF Form 813, Request for Environmental Impact Analysis.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false AF Form 813, Request for Environmental Impact... FORCE ENVIRONMENTAL PROTECTION ENVIRONMENTAL IMPACT ANALYSIS PROCESS (EIAP) § 989.12 AF Form 813, Request for Environmental Impact Analysis. The Air Force uses AF Form 813 to document the need for...

  13. Diagnostic staging laparoscopy in gastric cancer treatment: A cost-effectiveness analysis.

    Science.gov (United States)

    Li, Kevin; Cannon, John G D; Jiang, Sam Y; Sambare, Tanmaya D; Owens, Douglas K; Bendavid, Eran; Poultsides, George A

    2018-05-01

    Accurate preoperative staging helps avert morbidity, mortality, and cost associated with non-therapeutic laparotomy in gastric cancer (GC) patients. Diagnostic staging laparoscopy (DSL) can detect metastases with high sensitivity, but its cost-effectiveness has not been previously studied. We developed a decision analysis model to assess the cost-effectiveness of preoperative DSL in GC workup. Analysis was based on a hypothetical cohort of GC patients in the U.S. for whom initial imaging shows no metastases. The cost-effectiveness of DSL was measured as cost per quality-adjusted life-year (QALY) gained. Drivers of cost-effectiveness were assessed in sensitivity analysis. Preoperative DSL required an investment of $107 012 per QALY. In sensitivity analysis, DSL became cost-effective at a threshold of $100 000/QALY when the probability of occult metastases exceeded 31.5% or when test sensitivity for metastases exceeded 86.3%. The likelihood of cost-effectiveness increased from 46% to 93% when both parameters were set at maximum reported values. The cost-effectiveness of DSL for GC patients is highly dependent on patient and test characteristics, and is more likely when DSL is used selectively where procedure yield is high, such as for locally advanced disease or in detecting peritoneal and superficial versus deep liver lesions. © 2017 Wiley Periodicals, Inc.

  14. The nuclear interaction analysis methods for diagnostics of high power ion beam technologies

    Energy Technology Data Exchange (ETDEWEB)

    Ryzhkov, V A; Grushin, I I; Remnev, G E [Nuclear Physics Inst., Tomsk (Russian Federation)

    1997-12-31

    The complex of Nuclear Interaction Analysis Methods including charged particle activation analysis (CPAA and HIAA), spectrometry of ion induced gamma-emission (PIGE and HIIGE) , characteristic X-ray emission (PIXE), and Rutherford Backscattering Spectrometry (RBS), have been used for diagnostics of the High Power Ion Beam (HPIB) assisted technologies. Accelerated ion beams from the EG-2.5 electrostatic generator and U-120 cyclotron were used for implementation of the techniques. The complex allows a lot of problems of elemental and isotopic analysis to be addressed. First, it is the determination of micro- and macrocomponents of modified materials; second, determination of surface density of thin films, multilayers and coatings, total surface gaseous contamination and amounts of the elements implanted in specimens; third, measurement of concentration depth profiles of the elements. Experiments have shown that the preferable application of nuclear analysis methods allows us to avoid the considerable errors arising when the concentration depth profiles of elements are measured by SIMS or AES in studies of mass transfer processes induced by HPIBs. (author). 1 tab., 2 figs., 3 refs.

  15. Vulnerability analysis of DT fusion diagnostics for laser Megajoule facility. A new tool: Diacad

    International Nuclear Information System (INIS)

    D'hose, C.; Baggio, J.; Musseau, O.

    1999-01-01

    The Megajoule laser (LMJ) project is a major component of the French simulation program to study inertial confinement. This new facility will provide an energy 60 times greater than the largest lasers presently available (Phebus, Nova, Omega). Many diagnostic links will have to be developed in order to acquire complementary knowledge in this domain. A computer based tool has been defined. This paper presents the most recent developments of this new CAD (computer assisted diagnosis) tool. We first describe LMJ context, and then the analysis methodology developed to address the sensitivity to transient radiation of nuclear diagnosis links. This tool takes into account the vulnerability of individual parts and the global structure of the link. (A.C.)

  16. Data and Analysis from a Time-Resolved Tomographic Optical Beam Diagnostic

    International Nuclear Information System (INIS)

    Frayer, Daniel K.; Johnson, Douglas; Ekdahl, Carl

    2010-01-01

    An optical tomographic diagnostic instrument developed for the acquisition of high-speed time-resolved images has been fielded at the Dual-Axis Radiographic Hydrodynamic Test (DARHT) Facility at Los Alamos National Laboratory. The instrument was developed for the creation of time histories of electron-beam cross section through the collection of Cerenkov light. Four optical lines of sight optically collapse an image and relay projections via an optical fiber relay to recording instruments; a tomographic reconstruction algorithm creates the time history. Because the instrument may be operated in an adverse environment, it may be operated, adjusted, and calibrated remotely. The instrument was operated over the course of various activities during and after DARHT commissioning, and tomographic reconstructions reported verifiable beam characteristics. Results from the collected data and reconstructions and analysis of the data are discussed.

  17. Risk analysis for working with an analyzer for gamma cameras diagnostic

    International Nuclear Information System (INIS)

    Oramas Polo, Ivon; Figueroa del Valle, Diana G.

    2014-01-01

    In this work, an analysis of the risks for working with an analyzer for gamma cameras diagnostic was made. The method employed is based on determining the Hazard Rating Number (HRN). The results showed that the risks with higher value of HRN are electrocution with 100 and touch source container with hands with 75. These risks were classified as 'Very High' and 'High' respectively. The following risks were classified as 'Important': Fall of the source container (HRN = 25), high dose of the sample in the container (HRN = 20) and fracture of glass detector (HRN = 30). The wrong shielding of the source container (HRN = 10) is a risk that was classified as L ow . Safety rules for use of the system are indicated. An action plan for risk management is also presented. (author)

  18. Cost-effectiveness analysis of introducing malaria diagnostic testing in drug shops

    DEFF Research Database (Denmark)

    Hansen, Kristian Schultz; Clarke, Siân E.; Lal, Sham

    2017-01-01

    Background Private sector drug shops are an important source of malaria treatment in Africa, yet diagnosis without parasitological testing is common among these providers. Accurate rapid diagnostic tests for malaria (mRDTs) require limited training and present an opportunity to increase access...... to correct diagnosis. The present study was a cost-effectiveness analysis of the introduction of mRDTs in Ugandan drug shops. Methods Drug shop vendors were trained to perform and sell subsidised mRDTs and artemisinin-based combination therapies (ACTs) in the intervention arm while vendors offered ACTs...... following presumptive diagnosis of malaria in the control arm. The effect on the proportion of customers with fever ‘appropriately treated of malaria with ACT’ was captured during a randomised trial in drug shops in Mukono District, Uganda. Health sector costs included: training of drug shop vendors...

  19. The diagnostic value of power spectra analysis of the sleep electroencephalography in narcoleptic patients

    DEFF Research Database (Denmark)

    Christensen, Julie Anja Engelhard; Munk, Emil Gammelmark Schreiner; Peppard, Paul E.

    2015-01-01

    Objective: Manifestations of narcolepsy with cataplexy (NC) include disturbed nocturnal sleep – hereunder sleep–wake instability, decreased latency to rapid eye movement (REM) sleep, and dissociated REM sleep events. In this study, we characterized the electroencephalography (EEG) of various sleep...... show (1) increased alpha power in REM sleep, (2) decreased sigma power in wakefulness, and (3) decreased delta power in stage N1 versus wakefulness. Sensitivity of these features ranged from 4% to 10% with specificity around 98%, and it did not vary substantially with and without treatment. Conclusions......: EEG spectral analysis of REM sleep, wake, and differences between N1 and wakefulness contain diagnostic features of NC. These traits may represent sleepiness and dissociated REM sleep in patients with NC. However, the features are not sufficient for differentiating NC from controls, and further...

  20. The potential diagnostic power of circulating tumor cell analysis for non-small-cell lung cancer.

    Science.gov (United States)

    Ross, Kirsty; Pailler, Emma; Faugeroux, Vincent; Taylor, Melissa; Oulhen, Marianne; Auger, Nathalie; Planchard, David; Soria, Jean-Charles; Lindsay, Colin R; Besse, Benjamin; Vielh, Philippe; Farace, Françoise

    2015-01-01

    In non-small-cell lung cancer (NSCLC), genotyping tumor biopsies for targetable somatic alterations has become routine practice. However, serial biopsies have limitations: they may be technically difficult or impossible and could incur serious risks to patients. Circulating tumor cells (CTCs) offer an alternative source for tumor analysis that is easily accessible and presents the potential to identify predictive biomarkers to tailor therapies on a personalized basis. Examined here is our current knowledge of CTC detection and characterization in NSCLC and their potential role in EGFR-mutant, ALK-rearranged and ROS1-rearranged patients. This is followed by discussion of the ongoing issues such as the question of CTC partnership as diagnostic tools in NSCLC.

  1. Data Analysis of the Gated-LEH X-Ray Imaging Diagnostic at the NIF

    Science.gov (United States)

    Thibodeau, Matthew; Chen, Hui

    2017-10-01

    The Gated Laser Entrance Hole (G-LEH) x-ray imaging diagnostic in use at the NIF offers a desirable combination of spatial and temporal resolution. By looking inside of NIF hohlraums with time resolution, G-LEH measures target features including LEH size and capsule size. A framework is presented for automated and systematic analysis of G-LEH images that measures several physical parameters of interest and their evolution over time. The results from these analyses enable comparisons with hohlraum models and allow model validation of LEH closure velocity and the extent of capsule blow-off. This work was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  2. Applied research on environmental pollution using INAA. A study on the environmental indicator analysis

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Nak Bae; Lee, Gil Yong; Yoon, Yoon Yul; Chon, Sang Ki [Korea Institute of Geology Mining and Research, Taejon (Korea, Republic of)

    1995-08-01

    Among the many kinds of environmental indicator samples such as moss, lichen, pine needle, pine needle was selected as a bio-monitor and collected sample was divided two groups and one was washed with 1% hydrochloric acid to remove the elements deposited on surface. Trace elements in pine needle were analyzed by the decay time of each nuclide. Analytical accuracy was tested by analyzing NIST SRM 1575 pine needle. Results are follows: (1) Environmental indicator as a bio-monitor pine needle was selected. (2) The content difference of the trace elements between sampling period was monitored. And as content was varied with sampling time. (3) To monitor the influence of atmospheric deposition the surface of pine needle was washed with 1% hydrochloric acid. Therefore, As, Ce, La, Na, W, and Zn contents were decreased by washing. (4) Non-destructive INAA (Instrumental Neutron Activation Analysis) technique was developed for the determination of trace elements in environmental samples. (5) Analytical accuracy was tested by analyzing NIST SRM 1575 pine needle, and the accuracy was well agreed within 10% deviation. summarized. (author). 18 refs., 8 figs., 5 tabs.

  3. Precision of neutron activation analysis for environmental biological materials

    International Nuclear Information System (INIS)

    Hamaguchi, Hiroshi; Iwata, Shiro; Koyama, Mutsuo; Sasajima, Kazuhisa; Numata, Yuichi.

    1977-01-01

    Between 1973 and 1974 a special committee ''Research on the application of neutron activation analysis to the environmental samples'' had been organized at the Research Reactor Institute, Kyoto University. Eleven research groups composed mainly of the committee members cooperated in the intercomparison programme of the reactor neutron activation analysis of NBS standard reference material, 1571 Orchard Leaves and 1577 Bovine Liver. Five different type of reactors were used for the neutron irradiation; i.e. KUR reactor of the Research Reactor Institute, Kyoto University, TRIGA MARK II reactor of the Institute for Atomic Energy, Rikkyo University, and JRR-2, JRR-3, JRR-4 reactor of Japan Atomic Energy Research Institute. Analyses were performed mainly by instrumental method. Precision of the analysis of 23 elements in Orchard Leaves and 13 elements in Bovine Liver presented by the different research groups was shown in table 4 and 5, respectively. The coefficient of variation for these elements was from several to -- 30 percent. Averages given to these elements agreed well with the NBS certified or reference values. Thus, from the practical point of view for the routine multielement analysis of environmental samples, the validity of the instrumental neutron activation technique for this purpose has been proved. (auth.)

  4. Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials.

    Science.gov (United States)

    Siontis, George Cm; Mavridis, Dimitris; Greenwood, John P; Coles, Bernadette; Nikolakopoulou, Adriani; Jüni, Peter; Salanti, Georgia; Windecker, Stephan

    2018-02-21

    To evaluate differences in downstream testing, coronary revascularisation, and clinical outcomes following non-invasive diagnostic modalities used to detect coronary artery disease. Systematic review and network meta-analysis. Medline, Medline in process, Embase, Cochrane Library for clinical trials, PubMed, Web of Science, SCOPUS, WHO International Clinical Trials Registry Platform, and Clinicaltrials.gov. Diagnostic randomised controlled trials comparing non-invasive diagnostic modalities in patients presenting with symptoms suggestive of low risk acute coronary syndrome or stable coronary artery disease. A random effects network meta-analysis synthesised available evidence from trials evaluating the effect of non-invasive diagnostic modalities on downstream testing and patient oriented outcomes in patients with suspected coronary artery disease. Modalities included exercise electrocardiograms, stress echocardiography, single photon emission computed tomography-myocardial perfusion imaging, real time myocardial contrast echocardiography, coronary computed tomographic angiography, and cardiovascular magnetic resonance. Unpublished outcome data were obtained from 11 trials. 18 trials of patients with low risk acute coronary syndrome (n=11 329) and 12 trials of those with suspected stable coronary artery disease (n=22 062) were included. Among patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography (odds ratio 0.28 (95% confidence interval 0.14 to 0.57), 0.32 (0.15 to 0.71), and 0.53 (0.28 to 1.00), respectively). There was no effect on the subsequent risk of myocardial infarction, but estimates were imprecise. Heterogeneity and inconsistency were low. In patients with suspected stable coronary artery disease, an initial diagnostic strategy of stress echocardiography or

  5. Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials

    Science.gov (United States)

    Siontis, George CM; Mavridis, Dimitris; Greenwood, John P; Coles, Bernadette; Nikolakopoulou, Adriani; Jüni, Peter; Salanti, Georgia

    2018-01-01

    Abstract Objective To evaluate differences in downstream testing, coronary revascularisation, and clinical outcomes following non-invasive diagnostic modalities used to detect coronary artery disease. Design Systematic review and network meta-analysis. Data sources Medline, Medline in process, Embase, Cochrane Library for clinical trials, PubMed, Web of Science, SCOPUS, WHO International Clinical Trials Registry Platform, and Clinicaltrials.gov. Eligibility criteria for selecting studies Diagnostic randomised controlled trials comparing non-invasive diagnostic modalities in patients presenting with symptoms suggestive of low risk acute coronary syndrome or stable coronary artery disease. Data synthesis A random effects network meta-analysis synthesised available evidence from trials evaluating the effect of non-invasive diagnostic modalities on downstream testing and patient oriented outcomes in patients with suspected coronary artery disease. Modalities included exercise electrocardiograms, stress echocardiography, single photon emission computed tomography-myocardial perfusion imaging, real time myocardial contrast echocardiography, coronary computed tomographic angiography, and cardiovascular magnetic resonance. Unpublished outcome data were obtained from 11 trials. Results 18 trials of patients with low risk acute coronary syndrome (n=11 329) and 12 trials of those with suspected stable coronary artery disease (n=22 062) were included. Among patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography (odds ratio 0.28 (95% confidence interval 0.14 to 0.57), 0.32 (0.15 to 0.71), and 0.53 (0.28 to 1.00), respectively). There was no effect on the subsequent risk of myocardial infarction, but estimates were imprecise. Heterogeneity and inconsistency were low. In patients with

  6. Deconstructing Bipolar Disorder and Schizophrenia: A cross-diagnostic cluster analysis of cognitive phenotypes.

    Science.gov (United States)

    Lee, Junghee; Rizzo, Shemra; Altshuler, Lori; Glahn, David C; Miklowitz, David J; Sugar, Catherine A; Wynn, Jonathan K; Green, Michael F

    2017-02-01

    Bipolar disorder (BD) and schizophrenia (SZ) show substantial overlap. It has been suggested that a subgroup of patients might contribute to these overlapping features. This study employed a cross-diagnostic cluster analysis to identify subgroups of individuals with shared cognitive phenotypes. 143 participants (68 BD patients, 39 SZ patients and 36 healthy controls) completed a battery of EEG and performance assessments on perception, nonsocial cognition and social cognition. A K-means cluster analysis was conducted with all participants across diagnostic groups. Clinical symptoms, functional capacity, and functional outcome were assessed in patients. A two-cluster solution across 3 groups was the most stable. One cluster including 44 BD patients, 31 controls and 5 SZ patients showed better cognition (High cluster) than the other cluster with 24 BD patients, 35 SZ patients and 5 controls (Low cluster). BD patients in the High cluster performed better than BD patients in the Low cluster across cognitive domains. Within each cluster, participants with different clinical diagnoses showed different profiles across cognitive domains. All patients are in the chronic phase and out of mood episode at the time of assessment and most of the assessment were behavioral measures. This study identified two clusters with shared cognitive phenotype profiles that were not proxies for clinical diagnoses. The finding of better social cognitive performance of BD patients than SZ patients in the Lowe cluster suggest that relatively preserved social cognition may be important to identify disease process distinct to each disorder. Copyright © 2016 Elsevier B.V. All rights reserved.

  7. Automatic Decision Support for Clinical Diagnostic Literature Using Link Analysis in a Weighted Keyword Network.

    Science.gov (United States)

    Li, Shuqing; Sun, Ying; Soergel, Dagobert

    2017-12-23

    We present a novel approach to recommending articles from the medical literature that support clinical diagnostic decision-making, giving detailed descriptions of the associated ideas and principles. The specific goal is to retrieve biomedical articles that help answer questions of a specified type about a particular case. Based on the filtered keywords, MeSH(Medical Subject Headings) lexicon and the automatically extracted acronyms, the relationship between keywords and articles was built. The paper gives a detailed description of the process of by which keywords were measured and relevant articles identified based on link analysis in a weighted keywords network. Some important challenges identified in this study include the extraction of diagnosis-related keywords and a collection of valid sentences based on the keyword co-occurrence analysis and existing descriptions of symptoms. All data were taken from medical articles provided in the TREC (Text Retrieval Conference) clinical decision support track 2015. Ten standard topics and one demonstration topic were tested. In each case, a maximum of five articles with the highest relevance were returned. The total user satisfaction of 3.98 was 33% higher than average. The results also suggested that the smaller the number of results, the higher the average satisfaction. However, a few shortcomings were also revealed since medical literature recommendation for clinical diagnostic decision support is so complex a topic that it cannot be fully addressed through the semantic information carried solely by keywords in existing descriptions of symptoms. Nevertheless, the fact that these articles are actually relevant will no doubt inspire future research.

  8. Using SWE Standards for Ubiquitous Environmental Sensing: A Performance Analysis

    Directory of Open Access Journals (Sweden)

    Joaquín Huerta

    2012-08-01

    Full Text Available Although smartphone applications represent the most typical data consumer tool from the citizen perspective in environmental applications, they can also be used for in-situ data collection and production in varied scenarios, such as geological sciences and biodiversity. The use of standard protocols, such as SWE, to exchange information between smartphones and sensor infrastructures brings benefits such as interoperability and scalability, but their reliance on XML is a potential problem when large volumes of data are transferred, due to limited bandwidth and processing capabilities on mobile phones. In this article we present a performance analysis about the use of SWE standards in smartphone applications to consume and produce environmental sensor data, analysing to what extent the performance problems related to XML can be alleviated by using alternative uncompressed and compressed formats.

  9. Environmental pressure group strength and air pollution. An empirical analysis

    Energy Technology Data Exchange (ETDEWEB)

    Binder, Seth; Neumayer, Eric [Department of Geography and Environment and Center for Environmental Policy and Governance (CEPG), London School of Economics and Political Science, Houghton Street, London WC2A 2AE (United Kingdom)

    2005-12-01

    There is an established theoretical and empirical case-study literature arguing that environmental pressure groups have a real impact on pollution levels. Our original contribution to this literature is to provide the first systematic quantitative test of the strength of environmental non-governmental organizations (ENGOs) on air pollution levels. We find that ENGO strength exerts a statistically significant impact on sulfur dioxide, smoke and heavy particulates concentration levels in a cross-country time-series regression analysis. This result holds true both for ordinary least squares and random-effects estimation. It is robust to controlling for the potential endogeneity of ENGO strength with the help of instrumental variables. The effect is also substantively important. Strengthening ENGOs represents an important strategy by which aid donors, foundations, international organizations and other stakeholders can try to achieve lower pollution levels around the world.

  10. Performance Test of Alpha Spectrometry for Environmental Radioactivity Analysis

    International Nuclear Information System (INIS)

    Choi, Jung Youn; Yoon, Jong-Ho; Han, Ki-Tek; Ahn, Gil Hoon

    2015-01-01

    Environmental samples are analyzed by various methods such as, ICP-MS (inductively coupled plasma mass spectrometry), AMS (accelerator mass spectrometry) TIMS (thermal ionization mass spectrometry), HRGS (high resolution gamma spectrometry) and alpha /beta particle analysis. In this study, we will described the result of performance test using alpha spectrometry for analyzing environmental samples. Measurement data of the U activity using SRM based on extraction chromatography with UTEVA resin. It should be effective way to separate of uranium isotope for the measurement of alpha spectrometry. But, the result of this measurement data is higher than another recovery data. Also concentration of U data is lack of consistency. We leave out of consideration many effect of factors about influence in the experiment process. In the future work, we will try to reduce the step of experiment process and reflect the uncertainty factors

  11. Environmental pressure group strength and air pollution. An empirical analysis

    International Nuclear Information System (INIS)

    Binder, Seth; Neumayer, Eric

    2005-01-01

    There is an established theoretical and empirical case-study literature arguing that environmental pressure groups have a real impact on pollution levels. Our original contribution to this literature is to provide the first systematic quantitative test of the strength of environmental non-governmental organizations (ENGOs) on air pollution levels. We find that ENGO strength exerts a statistically significant impact on sulfur dioxide, smoke and heavy particulates concentration levels in a cross-country time-series regression analysis. This result holds true both for ordinary least squares and random-effects estimation. It is robust to controlling for the potential endogeneity of ENGO strength with the help of instrumental variables. The effect is also substantively important. Strengthening ENGOs represents an important strategy by which aid donors, foundations, international organizations and other stakeholders can try to achieve lower pollution levels around the world

  12. Time perspective and environmental engagement: a meta-analysis.

    Science.gov (United States)

    Milfont, Taciano L; Wilson, Jessie; Diniz, Pollyane

    2012-01-01

    Environmental issues entail both a social conflict (private vs. public interests) and a temporal conflict (short- vs. long-term interests). This paper focuses on the role temporal concerns play in influencing environmental engagement by quantitatively integrating results of studies that assessed the associations between time perspective and proenvironmental attitudes and behaviors. The meta-analysis included a total of 19 independent samples and 6,301 participants from seven countries (Australia, Brazil, Germany, Mexico, New Zealand, Norway, and the United States). Results showed that the associations between time perspective and proenvironmental behaviors were higher than those for proenvironmental attitudes. Supporting predictions, the associations between future time perspective and proenvironmental behaviors were strong and nontrivial compared to those for the combined past-present time perspective. The findings indicate that future time perspective seems to play an important role in influencing individuals' attitudes and behaviors towards the environment. Implications of the findings for theory and practice are discussed.

  13. Calibration of a PIXE system for analysis of environmental aerosols

    International Nuclear Information System (INIS)

    Aldape, F.; Diaz, R.V.; Anguiano, G.; Flores M, J.

    1991-04-01

    The results of the calibration of the PIXE system for analysis of environmental aerosols in the CNM is presented. The system was calibrated in order to lead to the project study of environmental aerosols using PIXE from the qualitative dimension to the quantitative one. Part of this work it was carried out in collaboration with the expert of the IAEA Dr. D. Crumpton. The calibration of the system it was achieved bombarding thin targets of well-known composition with protons of 2.5 MeV. Using this technique it was determined the absolute elementary concentration in samples of atmospheric aerosols. As an example the calculation of the lead concentration in one of them whose result was of 662 ± 49 ng m -3 is presented. This value agrees with the measurements made in the Crocker Nuclear Lab of the UCD. Its are also discussed the reproducibility and precision of the used technique. (Author)

  14. Social Cost Benefit Analysis for Environmental Policy-Making

    International Nuclear Information System (INIS)

    De Zeeuw, A.; In t Veld, R.; Van Soest, D.; Meuleman, L.; Hoogewoning, P.

    2008-01-01

    Review of the theoretical literature and the current debate on the valuation of environmental goods and services, on the discounting of future benefits and costs, and on how social cost benefit analysis (SCBAs) can be integrated in the policy and decision making process. It is concluded that SCBA can be a good decision support method in environmental policy-making if it is transparent and if all impacts are taken into account. Furthermore, the SCBA process should be participative, and politicians must be prepared to take responsibility for the assumptions behind the SCBA, including the assumptions on valuation and on the discount rate. Such a political role makes each SCBA a unique product of a politically responsible actor, and makes it possible for other stakeholders to have calculated an alternative SCBA based on their own assumptions. This Background Study also contains the proceedings of the international SCBA conference organised by RMNO on 16-17 January 2008

  15. Analysis of the Environmental Impact on Remanufacturing Wind Turbines

    Science.gov (United States)

    Sosa Skrainka, Manuel R.

    To deliver clean energy the use of wind turbines is essential. In June 2011 there was an installed wind capacity equivalent to 211,000MW world-wide (WWEA, 2011). By the end of the year 2009 the U.S. had 35,100MW of wind energy installed capacity to generate electricity (AWEA, 2010). This industry has grown in recent years and is expected to grow even more in the future. The environmental impacts that will arise from the increased number of wind turbines and their end-of-life should be addressed, as large amounts of resources will be required to satisfy the current and future market demands for wind turbines. Since future 10MW wind turbines are expected to be as heavy as 1000 tons each, the study of the environmental response of profitable retirement strategies, such as remanufacturing for these machines, must be considered. Because of the increased number of wind turbines and the materials used, this study provides a comparison between the environmental impacts from remanufacturing the components installed inside the nacelle of multi-megawatt wind turbines and wind turbines manufactured using new components. The study methodology is the following: • Describe the life-cycle and the materials and processes employed for the manufacture and remanufacturing for components inside the nacelle. • Identify remanufacturing alternatives for the components inside the nacelle at the end of the expected life-time service of wind turbines. • Evaluate the environmental impacts from the remanufactured components and compare the results with the impacts of the manufacturing of new components using SimaPro. • Conduct sensitivity analysis over the critical parameters of the life cycle assessment • Propose the most environmentally friendly options for the retirement of each major component of wind turbines. After an analysis of the scenarios the goal of the study is to evaluate remanufacturing as an end-of-life option from an environmental perspective for commercial multi

  16. The Application of Cognitive Diagnostic Approaches via Neural Network Analysis of Serious Educational Games

    Science.gov (United States)

    Lamb, Richard L.

    Serious Educational Games (SEGs) have been a topic of increased popularity within the educational realm since the early millennia. SEGs are generalized form of Serious Games to mean games for purposes other than entertainment but, that also specifically include training, educational purpose and pedagogy within their design. This rise in popularity (for SEGs) has occurred at a time when school systems have increased the type, number, and presentations of student achievement tests for decision-making purposes. These tests often task the form of end of course (year) tests and periodic benchmark testing. As the use of these tests, has increased policymakers have suggested their use as a measure for teacher accountability. The change in testing resulted from a push by school districts and policy makers at various component levels for a data-driven decision-making (D3M) approach. With the data-driven decision making approaches by school districts, there has been an increased focus on the measurement and assessment of student content knowledge with little focus on the contributing factors and cognitive attributes within learning that cross multiple-content areas. One-way to increase the focus on these aspects of learning (factors and attributes) that are additional to content learning is through assessments based in cognitive diagnostics. Cognitive diagnostics are a family of methodological approaches in which tasks tie to specific cognitive attributes for analytical purposes. This study explores data derived from computer data logging (n=158,000) in an observational design, using traditional statistical techniques such as clustering (exploratory and confirmatory), item response theory and through data mining techniques such as artificial neural network analysis. From these analyses, a model of student learning emerges illustrating student thinking and learning while engaged in SEG Design. This study seeks to use cognitive diagnostic type approaches to measure student

  17. Use of activation analysis of hair in environmental protection

    International Nuclear Information System (INIS)

    Obrusnik, I.

    1982-01-01

    Human hair is very suitable for use in environmental control monitoring because trace elements concentrate in it at higher levels than in most other organs. Unlike in other biological materials, the trace element contents in hair can be determined by instrumental neutron activation analysis (INAA), as the interference by 24 Na can be eliminated by appropriate washing of hair, e.g., using the procedure recommended by IAEA. The methods of sampling, washing and sample analysis using INAA and neutron activation analysis with radiochemical separation are described including the recommended way of the presentation of results. The results are presented of analyses for trace elements in hair from both little and highly polluted areas. (Ha)

  18. Diagnostic value of urinary kidney injury molecule 1 for acute kidney injury: a meta-analysis.

    Directory of Open Access Journals (Sweden)

    Xinghua Shao

    Full Text Available BACKGROUND: Urinary Kidney Injury Molecule 1 (KIM-1 is a proximal tubular injury biomarker for early detection of acute kidney injury (AKI, with variable performance characteristics depending on clinical and population settings. METHODS: Meta-analysis was performed to assess the diagnostic value of urinary KIM-1 in AKI. Relevant studies were searched from MEDLINE, EMBASE, Pubmed, Elsevier Science Direct, Scopus, Web of Science, Google Scholar and Cochrane Library. Meta-analysis methods were used to pool sensitivity and specificity and to construct summary receiver operating characteristic (SROC curves. RESULTS: A total of 2979 patients from 11 eligible studies were enrolled in the analysis. Five prospective cohorts, two cross-sectional and four case-control studies were identified for meta-analysis. The estimated sensitivity of urinary KIM-1 for the diagnosis of AKI was 74.0% (95% CI, 61.0%-84.0%, and specificity was 86.0% (95% CI, 74.0%-93.0%. The SROC analysis showed an area under the curve of 0.86(0.83-0.89. Subgroup analysis suggested that population settings and detection time were the key factors affecting the efficiency of KIM-1 for AKI diagnosis. LIMITATION: Various population settings, different definition of AKI and Serum creatinine level used as the standard might have influence on AKI diagnosis. The relatively small number of studies and heterogeneity between them also affected the evaluation. CONCLUSION: Urinary KIM-1 may be a promising biomarker for early detection of AKI with considerable predictive value, especially for cardiac surgery patients, and its potential value needs to be validated in large studies and across a broader scope of clinical settings.

  19. FINAL REPORT: Building Performance Optimization while Empowering Occupants Toward Environmentally Sustainable Behavior through Continuous Monitoring and Diagnostics

    Science.gov (United States)

    2016-12-05

    Federal Energy Management Program FM Facility Manager GHG Green House Gases HASP Health and Safety Plan HVAC Heating Ventilation and... workplace energy efficiency enhancement by the DOD personnel. 2.1.2 ID-F Intelligent Dashboards for Facility Managers Creation of the Base Building...demonstration project. The first technology, ‘ID-F,’ targets building facility managers and allows real time diagnostics for BAS systems with features

  20. Synchronous Analysis for Diagnostics of Rolling Bearings in the Turbojet Engine

    Directory of Open Access Journals (Sweden)

    Gosiewski Zdzisław

    2005-01-01

    Full Text Available Designed in the Aviation Institute, the K-15 turbojet engine has got rolling bearings, which answers with frequency 5.87 × ω r the unbalance excitation. The signal with such frequency indicates a fault of the outer race of the rolling bearing. A set of the digital synchronous filters was used for the K-15 vibration spectrum analysis. A procedure of filtration was performed by the computer software. The sychronous summation of the measured signals was carried out before the spectrum analysis. Two cases were considered: the engine with a small force due to unbalance (a small angular velocity of the rotor, and the engine with a big unbalance force (high angular velocity. In the first case, the outer race frequency was not observed, despite the existence of the vibration amplitude (caused by unknown disturbances with such frequency before the synchronous summation. In the second case, the outer race frequency after synchronous summation has enlarged amplitude while other spectrum components in its vicinity have been damped. It underlines the usefulness of the synchronous analysis in the vibration diagnostics of the rotating machinery.

  1. Multi-method analysis of MRI images in early diagnostics of Alzheimer's disease.

    Directory of Open Access Journals (Sweden)

    Robin Wolz

    Full Text Available The role of structural brain magnetic resonance imaging (MRI is becoming more and more emphasized in the early diagnostics of Alzheimer's disease (AD. This study aimed to assess the improvement in classification accuracy that can be achieved by combining features from different structural MRI analysis techniques. Automatically estimated MR features used are hippocampal volume, tensor-based morphometry, cortical thickness and a novel technique based on manifold learning. Baseline MRIs acquired from all 834 subjects (231 healthy controls (HC, 238 stable mild cognitive impairment (S-MCI, 167 MCI to AD progressors (P-MCI, 198 AD from the Alzheimer's Disease Neuroimaging Initiative (ADNI database were used for evaluation. We compared the classification accuracy achieved with linear discriminant analysis (LDA and support vector machines (SVM. The best results achieved with individual features are 90% sensitivity and 84% specificity (HC/AD classification, 64%/66% (S-MCI/P-MCI and 82%/76% (HC/P-MCI with the LDA classifier. The combination of all features improved these results to 93% sensitivity and 85% specificity (HC/AD, 67%/69% (S-MCI/P-MCI and 86%/82% (HC/P-MCI. Compared with previously published results in the ADNI database using individual MR-based features, the presented results show that a comprehensive analysis of MRI images combining multiple features improves classification accuracy and predictive power in detecting early AD. The most stable and reliable classification was achieved when combining all available features.

  2. Neutron activation analysis as analytical tool of environmental issue

    International Nuclear Information System (INIS)

    Otoshi, Tsunehiko

    2004-01-01

    Neutron activation analysis (NAA) ia applicable to the sample of wide range of research fields, such as material science, biology, geochemistry and so on. However, respecting the advantages of NAA, a sample with small amounts or a precious sample is the most suitable samples for NAA, because NAA is capable of trace analysis and non-destructive determination. In this paper, among these fields, NAA of atmospheric particulate matter (PM) sample is discussed emphasizing on the use of obtained data as an analytical tool of environmental issue. Concentration of PM in air is usually very low, and it is not easy to get vast amount of sample even using a high volume air sampling devise. Therefore, high sensitive NAA is suitable to determine elements in PM samples. Main components of PM is crust oriented silicate, and so on in rural/remote area, and carbonic materials and heavy metals are concentrated in PM in urban area, because of automobile exhaust and other anthropogenic emission source. Elemental pattern of PM reflects a condition of air around the monitoring site. Trends of air pollution can be traced by periodical monitoring of PM by NAA method. Elemental concentrations in air change by season. For example, crustal elements increase in dry season, and sea salts components increase their concentration when wind direction from sea is dominant. Elements that emitted from anthropogenic sources are mainly contained in fine portion of PM, and increase their concentration during winter season, when emission from heating system is high and air is stable. For further analysis and understanding of environmental issues, indicator elements for various emission sources, and elemental concentration ratios of some environmental samples and source portion assignment techniques are useful. (author)

  3. Diagnostic values of FibroScan and FibroTouch for liver fibrosis: a comparative analysis

    Directory of Open Access Journals (Sweden)

    WU Na

    2014-07-01

    Full Text Available ObjectiveTo compare the diagnostic values of FibroScan and FibroTouch for liver fibrosis. MethodsA total of 962 patients who visited Department of Hepatology, The First Hospital of Jilin University from September 2013 to March 2014 were enrolled. FibroScan and FibroTouch were performed among these patients. Thirty-three cases underwent liver biopsy, and Aspartate aminotransferase-to-platelet ratio index (APRI was calculated in 66 patients (chronic hepatitis B (CHB: 53 cases; chronic hepatitis C (CHC: 13 cases. Spearman rank correlation test was used to analyze the correlation between the results measured by FibroScan and FibroTouch. The diagnostic values of FibroScan and FibroTouch for liver fibrosis were analyzed and compared by receiver operating characteristic (ROC curve. ResultsThe analysis of liver stiffness measured by FibroScan and FibroTouch among all patients showed that the correlation coefficient between FibroScan and FibroTouch was 0.866 (P<0.05, n=962. FibroScan and FibroTouch were significantly correlated with APRI (r=0.58 and 0.63, P<0.05, n=66 and pathological stage determined by liver biopsy (r=0.67 and 0.74, P<0.05, n=33. Among patients with CHB, for the diagnosis of APRI ≥2 (liver cirrhosis, the areas under the ROC curve (AUCs of FibroScan and FibroTouch were 0.761 vs 0.728 (P=0.61; among patients with CHC, for the diagnosis of APRI ≥1 (liver cirrhosis, the AUCs of FibroScan and FibroTouch were 0.810 vs 0.893 (P=0.38. For pathological stages ≥S1, ≥S2, ≥S3, and ≥S4, the AUCs of FibroScan and FibroTouch were 0.830 vs 0.889 (P=0.15, 0.841 vs 0.835 (P=0.90, 0.888 vs 0.920 (P=0.43, and 0.964 vs 0.979 (P=0.45, respectively. ConclusionFibroScan and FibroTouch have comparable diagnostic values for liver fibrosis. However, the number of cases undergoing liver biopsy in this study was relatively small, and investigation of more cases is needed to make further confirmation.

  4. Diagnostic Performance of Magnifying Endoscopy for Helicobacter pylori Infection: A Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Qingqing Qi

    Full Text Available Diagnosis of Helicobacter pylori (H. pylori infection using magnifying endoscopy offers advantages over conventional invasive and noninvasive tests.This meta-analysis aimed to assess the diagnostic performance of magnifying endoscopy in the prediction of H. pylori infection.A literature search of the PubMed, Medline, EMBASE, Science Direct and the Cochrane Library databases was performed. A random-effects model was used to calculate the diagnostic efficiency of magnifying endoscopy for H. pylori infection. A summary receiver operator characteristic curve was plotted, and the area under the curve (AUC was calculated.A total of 18 studies involving 1897 patients were included. The pooled sensitivity and specificity of magnifying endoscopy to predict H. pylori infection were 0.89 [95% confidence interval (CI 0.87-0.91] and 0.82 (95%CI 0.79-0.85, respectively, with an AUC of 0.9461. When targeting the gastric antrum, the pooled sensitivity and specificity were 0.82 (95%CI 0.78-0.86 and 0.72 (95%CI 0.66-0.78, respectively. When targeting the gastric corpus, the pooled sensitivity and specificity were 0.92 (95%CI 0.90-0.94 and 0.86 (95%CI 0.82-0.88, respectively. The pooled sensitivity and specificity using magnifying white light endoscopy were 0.90 (95%CI 0.87-0.91 and 0.81 (95%CI 0.77-0.84, respectively. The pooled sensitivity and specificity using magnifying chromoendoscopy were 0.87 (95%CI 0.83-0.91 and 0.85 (95%CI 0.80-0.88, respectively. The "pit plus vascular pattern" classification in the gastric corpus observed by magnifying endoscopy was able to accurately predict the status of H. pylori infection, as indicated by a pooled sensitivity and specificity of 0.96 (95%CI 0.94-0.97 and 0.91 (95%CI 0.87-0.93, respectively, with an AUC of 0.9872.Magnifying endoscopy was able to accurately predict the status of H. pylori infection, either in magnifying white light endoscopy or magnifying chromoendoscopy mode. The "pit plus vascular pattern

  5. Nonactivation interaction techniques in the analysis of environmental samples

    International Nuclear Information System (INIS)

    Tolgyessy, J.

    1986-01-01

    Nonactivation interaction analytical methods are based on the interaction processes of nuclear and X-ray radiation with a sample, leading to their absorption and backscattering, to the ionization of gases or excitation of fluorescent X-ray by radiation, but not to the activation of determined elements. From the point of view of environmental analysis, the most useful nonactivation interaction techniques are X-ray fluorescence by photon or charged particle excitation, ionization of gases by nuclear radiation, elastic scattering of charged particles and backscattering of beta radiation. The significant advantage of these methods is that they are nondestructive. (author)

  6. Multicriteria decision analysis: Overview and implications for environmental decision making

    Science.gov (United States)

    Hermans, Caroline M.; Erickson, Jon D.; Erickson, Jon D.; Messner, Frank; Ring, Irene

    2007-01-01

    Environmental decision making involving multiple stakeholders can benefit from the use of a formal process to structure stakeholder interactions, leading to more successful outcomes than traditional discursive decision processes. There are many tools available to handle complex decision making. Here we illustrate the use of a multicriteria decision analysis (MCDA) outranking tool (PROMETHEE) to facilitate decision making at the watershed scale, involving multiple stakeholders, multiple criteria, and multiple objectives. We compare various MCDA methods and their theoretical underpinnings, examining methods that most realistically model complex decision problems in ways that are understandable and transparent to stakeholders.

  7. Development of Dynamic Spent Nuclear Fuel Environmental Effect Analysis Model

    International Nuclear Information System (INIS)

    Jeong, Chang Joon; Ko, Won Il; Lee, Ho Hee; Cho, Dong Keun; Park, Chang Je

    2010-07-01

    The dynamic environmental effect evaluation model for spent nuclear fuel has been developed and incorporated into the system dynamic DANESS code. First, the spent nuclear fuel isotope decay model was modeled. Then, the environmental effects were modeled through short-term decay heat model, short-term radioactivity model, and long-term heat load model. By using the developed model, the Korean once-through nuclear fuel cycles was analyzed. The once-through fuel cycle analysis was modeled based on the Korean 'National Energy Basic Plan' up to 2030 and a postulated nuclear demand growth rate until 2150. From the once-through results, it is shown that the nuclear power demand would be ∼70 GWe and the total amount of the spent fuel accumulated by 2150 would be ∼168000 t. If the disposal starts from 2060, the short-term decay heat of Cs-137 and Sr-90 isotopes are W and 1.8x10 6 W in 2100. Also, the total long-term heat load in 2100 will be 4415 MW-y. From the calculation results, it was found that the developed model is very convenient and simple for evaluation of the environmental effect of the spent nuclear fuel

  8. Comparative environmental analysis of waste brominated plastic thermal treatments

    International Nuclear Information System (INIS)

    Bientinesi, M.; Petarca, L.

    2009-01-01

    The aim of this research activity is to investigate the environmental impact of different thermal treatments of waste electric and electronic equipment (WEEE), applying a life cycle assessment methodology. Two scenarios were assessed, which both allow the recovery of bromine: (A) the co-combustion of WEEE and green waste in a municipal solid waste combustion plant, and (B) the staged-gasification of WEEE and combustion of produced syngas in gas turbines. Mass and energy balances on the two scenarios were set and the analysis of the life cycle inventory and the life cycle impact assessment were conducted. Two impact assessment methods (Ecoindicator 99 and Impact 2002+) were slightly modified and then used with both scenarios. The results showed that scenario B (staged-gasification) had a potentially smaller environmental impact than scenario A (co-combustion). In particular, the thermal treatment of staged-gasification was more energy efficient than co-combustion, and therefore scenario B performed better than scenario A, mainly in the impact categories of 'fossil fuels' and 'climate change'. Moreover, the results showed that scenario B allows a higher recovery of bromine than scenario A; however, Br recovery leads to environmental benefits for both the scenarios. Finally the study demonstrates that WEEE thermal treatment for energy and matter recovery is an eco-efficient way to dispose of this kind of waste

  9. Present status of neutron activation analysis in environmental research

    International Nuclear Information System (INIS)

    Steinnes, E.

    1984-01-01

    Neutron activation analysis, in spite of its many advantageous features, is less widely used than some alternative trace element techniques, and has been losing ground during the last decade. In the environmental field however there are still many problems which can be solved in a better way by the contribution of NAA. The combination of multi-element capability and high accuracy is of great importance in many studies related to atmospheric trace elements. Also in aquatic studies NAA still has a significant role to play. Applications to soils, sediments, and plant material have so far been limited, but there is a place for further development. The scope of NAA in environmental research may be extended by further use of pre-irradiation separations. NAA is particularly important in the certification of analytical reference materials in the environmental field. In future applications of NAA an appropriate combination with other analytical techniques will often be a requisite for success. The general future of NAA is dependent on the availability of nuclear reactors, radiochemical laboratoties and appropriate competence. 21 references

  10. Diagnostic accuracy of dual-source CT coronary angiography in patients with atrial fibrillation: Meta analysis

    Energy Technology Data Exchange (ETDEWEB)

    Sun, Gang, E-mail: cjr.sungang@vip.163.com [Department of Medical Imaging, Jinan Military General Hospital, No. 25, Shifan Road, Jinan, Shandong Province 250031 (China); Li, Min [Department of Medical Imaging, Jinan Military General Hospital, No. 25, Shifan Road, Jinan, Shandong Province 250031 (China); Jiang, Zhi-wei [Department of Health Statistics, School of Public Health, Fourth Military Medical University, No. 169, Changle West Road, Xi’an, Shaanxi 710032 (China); Xu, Lin [Department of Medical Cardiology, Jinan Military General Hospital, No. 25, Shifan Road, Jinan, Shandong Province 250031 (China); Peng, Zhao-hui; Ding, Juan; Li, Li [Department of Medical Imaging, Jinan Military General Hospital, No. 25, Shifan Road, Jinan, Shandong Province 250031 (China); Jin, Zhi-tao [Department of Cardiology, General Hospital of the Second Artillery, Beijing 100088 (China)

    2013-10-01

    Rationale and objective: To synthesize the available data to underscore the diagnostic accuracy of dual-source CT (DSCT) coronary angiography in patients with atrial fibrillation (AF). Materials and methods: We searched in the electronic databases of PubMed for all published studies that examined patients with AF using DSCT. We used an exact binomial rendition of the bivariate mixed-effects regression model to synthesize the diagnostic data. Results: The positive and negative likelihood ratios (LRs) at the patient level were 6.0 (CI, 3.6–10.1) and 0.03(CI, 0.004–0.2), respectively. The negative predictive values higher than 90% were available for a CAD prevalence <78%. The pooled vessel- and segment-level estimates showed higher positive and negative LRs than the patient-level estimates (15.3 [CI, 9.8–23.9] and 0.1 [CI, 0.07–0.3]; 25.1 [CI, 10.8–58.5] and 0.2 [CI, 0.2–0.3], respectively). No statistically significant heterogeneity between studies and publication bias were found at the patient level estimate. A sensitivity analysis showed that no study influenced the pooled results larger than 0.02. Conclusions: Cardiac angiography with DSCT can be applied as an imaging test for ruling out CAD in patient with AF. However, DSCT angiography may be not an effective tool for risk stratification for the high negative LR at the artery and segment levels.

  11. Multivariate analysis of diagnostic parameters derived from whole-kidney and parenchymal time-activity curves

    International Nuclear Information System (INIS)

    Bergmann, H.; Mostbeck, A.; Samal, M.; Nimmon, C.C.; Staudenherz, A.; Dudczak, R.

    2002-01-01

    Aim: In a previous work, we have confirmed earlier reports that time-activity curves of renal cortex provide additional useful diagnostic information. The aim of this experiment was to support the finding quantitatively using multiple regression. Materials and Methods: In a retrospective study, we have analyzed MAG3 renal data (90 kidneys in 57 children). Whole-kidney (WK) and parenchymal (PA) time-activity curves were extracted from 20 min pre-diuretic phase using standard WK and parenchymal fuzzy ROIs. Using multiple regression analysis, peak time, mean transit time, output efficiency, and four additional indices of residual activity in WK and PA ROIs were related to the maximum elimination rate (EM) of urine after the diuretic. The kidneys were divided into four groups according to the WK peak time (WKPT): WKPT longer than 0 (all kidneys), 5, 10, and 15 min. Results: Multiple correlation coefficients between the set of WK, PA, and WK+PA curve parameters (independent variables) and the log EM (dependent variable) for each group are summarized. Conclusions: Using pre-diuretic time-activity curves, it is possible to predict diuretic response. This can be useful when interpreting dubious results. Parenchymal curves predict diuretic response better than the whole-kidney curves. With increasing WKPT the whole-kidney curves become useless, while the parenchymal curves are still useful. Using both WK and PA curves produces the best results. This demonstrates that both WK and PA curves carry independent diagnostic information. The contribution obtained from the parenchymal curves certainly worth the difficulties and time required to draw additional ROIs. However, substantial efforts have to be given to the accurate and reproducible definition of parenchymal ROIs

  12. Software architecture and design of the web services facilitating climate model diagnostic analysis

    Science.gov (United States)

    Pan, L.; Lee, S.; Zhang, J.; Tang, B.; Zhai, C.; Jiang, J. H.; Wang, W.; Bao, Q.; Qi, M.; Kubar, T. L.; Teixeira, J.

    2015-12-01

    Climate model diagnostic analysis is a computationally- and data-intensive task because it involves multiple numerical model outputs and satellite observation data that can both be high resolution. We have built an online tool that facilitates this process. The tool is called Climate Model Diagnostic Analyzer (CMDA). It employs the web service technology and provides a web-based user interface. The benefits of these choices include: (1) No installation of any software other than a browser, hence it is platform compatable; (2) Co-location of computation and big data on the server side, and small results and plots to be downloaded on the client side, hence high data efficiency; (3) multi-threaded implementation to achieve parallel performance on multi-core servers; and (4) cloud deployment so each user has a dedicated virtual machine. In this presentation, we will focus on the computer science aspects of this tool, namely the architectural design, the infrastructure of the web services, the implementation of the web-based user interface, the mechanism of provenance collection, the approach to virtualization, and the Amazon Cloud deployment. As an example, We will describe our methodology to transform an existing science application code into a web service using a Python wrapper interface and Python web service frameworks (i.e., Flask, Gunicorn, and Tornado). Another example is the use of Docker, a light-weight virtualization container, to distribute and deploy CMDA onto an Amazon EC2 instance. Our tool of CMDA has been successfully used in the 2014 Summer School hosted by the JPL Center for Climate Science. Students had positive feedbacks in general and we will report their comments. An enhanced version of CMDA with several new features, some requested by the 2014 students, will be used in the 2015 Summer School soon.

  13. The meaning of diagnostic test results: A spreadsheet for swift data analysis

    International Nuclear Information System (INIS)

    MacEneaney, Peter M.; Malone, Dermot E.

    2000-01-01

    AIMS: To design a spreadsheet program to: (a) analyse rapidly diagnostic test result data produced in local research or reported in the literature; (b) correct reported predictive values for disease prevalence in any population; (c) estimate the post-test probability of disease in individual patients. MATERIALS AND METHODS: Microsoft Excel TM was used. Section A: a contingency (2 x 2) table was incorporated into the spreadsheet. Formulae for standard calculations [sample size, disease prevalence, sensitivity and specificity with 95% confidence intervals, predictive values and likelihood ratios (LRs)] were linked to this table. The results change automatically when the data in the true or false negative and positive cells are changed. Section B: this estimates predictive values in any population, compensating for altered disease prevalence. Sections C-F: Bayes' theorem was incorporated to generate individual post-test probabilities. The spreadsheet generates 95% confidence intervals, LRs and a table and graph of conditional probabilities once the sensitivity and specificity of the test are entered. The latter shows the expected post-test probability of disease for any pre-test probability when a test of known sensitivity and specificity is positive or negative. RESULTS: This spreadsheet can be used on desktop and palmtop computers. The MS Excel TM version can be downloaded via the Internet from the URL ftp://radiography.com/pub/Rad-data99.xls CONCLUSION: A spreadsheet is useful for contingency table data analysis and assessment of the clinical meaning of diagnostic test results. MacEneaney, P.M., Malone, D.E. (2000)

  14. Environmental Systems Research and Analysis FY 2000 Annual Report

    Energy Technology Data Exchange (ETDEWEB)

    David L. Miller; Castle, Peter Myer; Steven J. Piet

    2001-01-01

    The Environmental Systems Research (ESR) Program, a part of the Environmental Systems Research and Analysis (ESRA) Program, was implemented to enhance and augment the technical capabilities of the INEEL. Strengthening the Technical capabilities of the INEEL will provide the technical base to serve effectively as the Environmental Management Laboratory for the Office of Environmental Management (EM). This is a progress report for the third year of the ESR Program (FY 2000). A report of activities is presented for the five ESR research investment areas: (1) Transport Aspects of Selective Mass Transport Agents, (2) Chemistry of Environmental Surfaces, (3) Materials Dynamics, (4) Characterization Science, and (5) Computational Simulation of Mechanical and Chemical Systems. In addition to the five technical areas, the report describes activities in the Science and Technology Foundations element of the program, e.g., interfaces between ESR and the EM Science Program (EMSP) and the EM Focus Areas. The five research areas are subdivided into 18 research projects. FY 2000 research in these 18 projects has resulted in more than 50 technical papers that are in print, in press, in review, or in preparation. Additionally, more than 100 presentations were made at professional society meetings nationally and internationally. Work supported by this program was in part responsible for one of our researchers, Dr. Mason Harrup, receiving the Department of Energy’s “Bright Light” and “Energy at 23” awards. Significant accomplishments were achieved. Non-Destructive Assay hardware and software was deployed at the INEEL, enhancing the quality and efficiency of TRU waste characterization for shipment. The advanced tensiometer has been employed at numerous sites around the complex to determine hydrologic gradients in variably saturated vadose zones. An ion trap, secondary ion mass spectrometer (IT-SIMS) was designed and fabricated to deploy at the INEEL site to measure the

  15. Computer system for environmental sample analysis and data storage and analysis

    International Nuclear Information System (INIS)

    Brauer, F.P.; Fager, J.E.

    1976-01-01

    A mini-computer based environmental sample analysis and data storage system has been developed. The system is used for analytical data acquisition, computation, storage of analytical results, and tabulation of selected or derived results for data analysis, interpretation and reporting. This paper discussed the structure, performance and applications of the system

  16. Analysis and Interpretation of the Plasma Dynamic Response to Additional Heating Power using different Diagnostics

    International Nuclear Information System (INIS)

    Manini, A.

    2002-07-01

    development of this work, the Electron Cyclotron Emission system (ECE) of ASDEX Upgrade is crucial since it allows local measurements of the electron temperature with high temporal and spatial resolutions. The analysis and interpretation of perturbative MECH discharges for power deposition localisation using different diagnostics, such as ECE and SXR measurements, are presented. The most important problem is related to the phase locking between the MECH and the sawtooth activity of the plasma, which disturbs both ECE and SXR measurements. Several techniques have been adopted to circumvent this difficulty. In particular, the Singular Value Decomposition (SVD) and the Generalised Singular Value Decomposition (GSVD) have been tested in both TCV and ASDEX Upgrade discharges. However, both methods are incapable of treating the problem correctly, which leads to potential misinterpretation of the results. A new method based on system identification using the SVD (SI-SVD) is developed and applied. This method, within reasonable limits induced by the assumption of linearity, is capable of simultaneously separating the MECH from the sawtooth contributions to both ECE electron temperature measurements and SXR emission measurements. Such a method is in particular applied to a NBI heated ASDEX Upgrade discharge in which MECH is added in order to analyse electron heat transport in a mostly ion-heated plasma. Since the NBI heating is also partly modulated with short pulses, which coincide with the sawtooth crashes to improve their stability, both the MECH and the NBI deposition profiles are determined. Moreover, treating the signals with the SI-SVD procedure enables a study of the plasma dynamic response also at higher MECH harmonic numbers. The procedure is then used to analyse MECH discharges in TCV using different diagnostics. The profiles determined using the ECE and soft X-ray measurements are compared and interpreted, demonstrating in particular that line integrated soft X

  17. Environmental Chemical Analysis (by B. B. Kebbekus and S. Mitra)

    Science.gov (United States)

    Bower, Reviewed By Nathan W.

    1999-11-01

    This text helps to fill a void in the market, as there are relatively few undergraduate instrumental analysis texts designed specifically for the expanding population of environmental science students. R. N. Reeve's introductory, open-learning Environmental Analysis (Wiley, 1994) is one of the few, and it is aimed at a lower level and is less appropriate for traditional classroom study. Kebbekus and Mitra's book appears to be an update of I. Marr and M. Cresser's excellent 1983 text by the same name (and also published under the Chapman and Hall imprint). It assumes no background in instrumental methods of analysis but it does depend upon a good general chemistry background in kinetic and equilibrium calculations and the standard laboratory techniques found in a classical introduction to analytical chemistry. The slant taken by the authors is aimed more toward engineers, not only in the choice of topics, but also in how they are presented. For example, the statistical significance tests presented follow an engineering format rather than the standard used in analytical chemistry. This approach does not detract from the book's clarity. The writing style is concise and the book is generally well written. The earlier text, which has become somewhat of a classic, took the unusual step of teaching the instruments in the context of their environmental application. It was divided into sections on the "atmosphere", the "hydrosphere", the "lithosphere", and the "biosphere". This text takes a similar approach in the second half, with chapters on methods for air, water, and solid samples. Users who intend to use the book as a text instead of a reference will appreciate the addition of chapters in the first half of the book on spectroscopic, chromatographic, and mass spectrometric methods. The six chapters in these two parts of the book along with four chapters scattered throughout on environmental measurements, sampling, sample preparation, and quality assurance make a nice

  18. Identification of candidate diagnostic serum biomarkers for Kawasaki disease using proteomic analysis

    Science.gov (United States)

    Kimura, Yayoi; Yanagimachi, Masakatsu; Ino, Yoko; Aketagawa, Mao; Matsuo, Michie; Okayama, Akiko; Shimizu, Hiroyuki; Oba, Kunihiro; Morioka, Ichiro; Imagawa, Tomoyuki; Kaneko, Tetsuji; Yokota, Shumpei; Hirano, Hisashi; Mori, Masaaki

    2017-01-01

    Kawasaki disease (KD) is a systemic vasculitis and childhood febrile disease that can lead to cardiovascular complications. The diagnosis of KD depends on its clinical features, and thus it is sometimes difficult to make a definitive diagnosis. In order to identify diagnostic serum biomarkers for KD, we explored serum KD-related proteins, which differentially expressed during the acute and recovery phases of two patients by mass spectrometry (MS). We identified a total of 1,879 proteins by MS-based proteomic analysis. The levels of three of these proteins, namely lipopolysaccharide-binding protein (LBP), leucine-rich alpha-2-glycoprotein (LRG1), and angiotensinogen (AGT), were higher in acute phase patients. In contrast, the level of retinol-binding protein 4 (RBP4) was decreased. To confirm the usefulness of these proteins as biomarkers, we analyzed a total of 270 samples, including those collected from 55 patients with acute phase KD, by using western blot analysis and microarray enzyme-linked immunosorbent assays (ELISAs). Over the course of this experiment, we determined that the expression level of these proteins changes specifically in the acute phase of KD, rather than the recovery phase of KD or other febrile illness. Thus, LRG1 could be used as biomarkers to facilitate KD diagnosis based on clinical features. PMID:28262744

  19. Development of a diagnostic expert system for eddy current data analysis using applied artificial intelligence methods

    International Nuclear Information System (INIS)

    Upadhyaya, B.R.; Yan, W.; Henry, G.

    1999-01-01

    A diagnostic expert system that integrates database management methods, artificial neural networks, and decision-making using fuzzy logic has been developed for the automation of steam generator eddy current test (ECT) data analysis. The new system, known as EDDYAI, considers the following key issues: (1) digital eddy current test data calibration, compression, and representation; (2) development of robust neural networks with low probability of misclassification for flaw depth estimation; (3) flaw detection using fuzzy logic; (4) development of an expert system for database management, compilation of a trained neural network library, and a decision module; and (5) evaluation of the integrated approach using eddy current data. The implementation to field test data includes the selection of proper feature vectors for ECT data analysis, development of a methodology for large eddy current database management, artificial neural networks for flaw depth estimation, and a fuzzy logic decision algorithm for flaw detection. A large eddy current inspection database from the Electric Power Research Institute NDE Center is being utilized in this research towards the development of an expert system for steam generator tube diagnosis. The integration of ECT data pre-processing as part of the data management, fuzzy logic flaw detection technique, and tube defect parameter estimation using artificial neural networks are the fundamental contributions of this research. (orig.)

  20. Development of a diagnostic expert system for eddy current data analysis using applied artificial intelligence methods

    Energy Technology Data Exchange (ETDEWEB)

    Upadhyaya, B.R.; Yan, W. [Tennessee Univ., Knoxville, TN (United States). Dept. of Nuclear Engineering; Behravesh, M.M. [Electric Power Research Institute, Palo Alto, CA (United States); Henry, G. [EPRI NDE Center, Charlotte, NC (United States)

    1999-09-01

    A diagnostic expert system that integrates database management methods, artificial neural networks, and decision-making using fuzzy logic has been developed for the automation of steam generator eddy current test (ECT) data analysis. The new system, known as EDDYAI, considers the following key issues: (1) digital eddy current test data calibration, compression, and representation; (2) development of robust neural networks with low probability of misclassification for flaw depth estimation; (3) flaw detection using fuzzy logic; (4) development of an expert system for database management, compilation of a trained neural network library, and a decision module; and (5) evaluation of the integrated approach using eddy current data. The implementation to field test data includes the selection of proper feature vectors for ECT data analysis, development of a methodology for large eddy current database management, artificial neural networks for flaw depth estimation, and a fuzzy logic decision algorithm for flaw detection. A large eddy current inspection database from the Electric Power Research Institute NDE Center is being utilized in this research towards the development of an expert system for steam generator tube diagnosis. The integration of ECT data pre-processing as part of the data management, fuzzy logic flaw detection technique, and tube defect parameter estimation using artificial neural networks are the fundamental contributions of this research. (orig.)

  1. The diagnostic value of intraocular fluid analysis by polymerase chain reaction in Thai patients with uveitis.

    Science.gov (United States)

    Pathanapitoon, Kessara; Kongyai, Natedao; Sirirungsi, Wasna; de Groot-Mijnes, Jolanda D F; Leechanachai, Pranee; Choovuthayakorn, Janejit; Kunavisarut, Paradee; Rothova, Aniki

    2011-11-01

    Uveitis is a major cause of severe visual impairment throughout the world and can be initiated by various infectious and non-infectious causes. Early recognition of specific infections is important as the treatment with antimicrobial agents might stop the progression or even cure the eye disease. To determine the infectious causes of uveitis in Thailand, intraocular fluid samples of 100 HIV-negative patients and 47 HIV-positive patients with uveitis were examined using real-time PCR analysis for herpes simplex virus, varicella zoster virus, cytomegalovirus and Toxoplasma gondii. Positive PCR results were found in 33/100 (33%) HIV-negative patients and in 33/47 (70%) HIV-positive patients with uveitis. In Thailand, cytomegalovirus was identified as the most frequent cause of infectious uveitis in both HIV-negative and HIV-positive patients (49 and 91%, respectively). PCR analysis of intraocular samples in uveitis was a valuable diagnostic assay. The pattern of uveitis observed in the Far East differs from that found in the West. Copyright © 2011 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

  2. Draft Waste Management Programmatic Environmental Impact Statement for managing treatment, storage, and disposal of radioactive and hazardous waste. Volume 3, Appendix A: Public response to revised NOI, Appendix B: Environmental restoration, Appendix C, Environmental impact analysis methods, Appendix D, Risk

    International Nuclear Information System (INIS)

    1995-08-01

    Volume three contains appendices for the following: Public comments do DOE's proposed revisions to the scope of the waste management programmatic environmental impact statement; Environmental restoration sensitivity analysis; Environmental impacts analysis methods; and Waste management facility human health risk estimates

  3. 2004 Power marketing program. Final environmental impact statement. Volume 1 - summary and environmental analysis

    International Nuclear Information System (INIS)

    1997-02-01

    The Sierra Nevada Region proposes to develop a plan to allocate power within its marketing areas of California and Nevada. Five alternatives were analyzed based on the possible range of operations of the Central Valley Project (CVP) hydroelectric system, levels of power purchases, and customer group allocations. Scheduling of the hydropower generating plants is the key difference across the alternatives. The peaking, preferred, renewables, and no-action alternatives are based on scheduling to emphasize peaking power. The baseload alternative assumes steady water releases. The analysis found no significant impacts overall. However, peaking operations tend to result in the greatest benefits and least negative effects to resources where impacts could be quantified. The peaking alternative was selected as the environmentally preferred alternative. The peaking alternative would add up to 317 MW of load-carrying capacity during August compared to taking no action. The preferred alternative results in up to a 262-MW gain and the baseload alternative results in a loss of 581 MW in comparison to the no-action alternative. Although it is not possible to determine where or when any lost capacity would be made up, building replacement capacity would result in land-use impacts and the use of natural and financial resources. The baseload alternative would result in more stable pool fluctuation within regulating reservoirs, which may benefit resident fish, recreation, and cultural resources; but these effects would be minor and could not be quantified. Environmental impacts within the CVP are limited to fluctuations in the regulating reservoirs. Changes in allocations to customer groups result in negligible regional economic effects. The renewables alternative is similar in CVP operation to the peaking alternative and melds 50 MW of renewables with CVP hydropower. Its environmental impacts vary, depending on the presence of biomass in the resource mix. 84 refs., 44 figs., 27 tabs

  4. Radioactive kryptonates in the analysis of environmental samples

    International Nuclear Information System (INIS)

    Tolgyessy, J.

    1986-01-01

    The term ''radioactive Kryptonates'' is used for substances into which atoms or ions of the radioactive nuclide 85 Kr are incorporated. The basis of the use of radioactive Kryptonates in analytical chemistry is that during a chemical reaction the crystalline lattice of the kryptonated carrier is destroyed, the carrier consumed, and the radioactive krypton released (radio-release method). Analysis can be made with a calibration curve or by comparison with a standard. Radio-release methods with the aid of radioactive Kryptonates as analytical reagents are very useful for the analysis of environmental samples, e.g. for the determination of air pollutants (ozone, sulphur dioxide, fluorine, hydrogen fluoride, mercury); and water pollutants (oxygen, dichromate, vanadium, hydrochloric acid, sulphur dioxide). (author)

  5. A hyperspectral image analysis workbench for environmental science applications

    Energy Technology Data Exchange (ETDEWEB)

    Christiansen, J.H.; Zawada, D.G.; Simunich, K.L.; Slater, J.C.

    1992-10-01

    A significant challenge to the information sciences is to provide more powerful and accessible means to exploit the enormous wealth of data available from high-resolution imaging spectrometry, or ``hyperspectral`` imagery, for analysis, for mapping purposes, and for input to environmental modeling applications. As an initial response to this challenge, Argonne`s Advanced Computer Applications Center has developed a workstation-based prototype software workbench which employs Al techniques and other advanced approaches to deduce surface characteristics and extract features from the hyperspectral images. Among its current capabilities, the prototype system can classify pixels by abstract surface type. The classification process employs neural network analysis of inputs which include pixel spectra and a variety of processed image metrics, including image ``texture spectra`` derived from fractal signatures computed for subimage tiles at each wavelength.

  6. A hyperspectral image analysis workbench for environmental science applications

    Energy Technology Data Exchange (ETDEWEB)

    Christiansen, J.H.; Zawada, D.G.; Simunich, K.L.; Slater, J.C.

    1992-01-01

    A significant challenge to the information sciences is to provide more powerful and accessible means to exploit the enormous wealth of data available from high-resolution imaging spectrometry, or hyperspectral'' imagery, for analysis, for mapping purposes, and for input to environmental modeling applications. As an initial response to this challenge, Argonne's Advanced Computer Applications Center has developed a workstation-based prototype software workbench which employs Al techniques and other advanced approaches to deduce surface characteristics and extract features from the hyperspectral images. Among its current capabilities, the prototype system can classify pixels by abstract surface type. The classification process employs neural network analysis of inputs which include pixel spectra and a variety of processed image metrics, including image texture spectra'' derived from fractal signatures computed for subimage tiles at each wavelength.

  7. CADDIS Volume 4. Data Analysis: Biological and Environmental Data Requirements

    Science.gov (United States)

    Overview of PECBO Module, using scripts to infer environmental conditions from biological observations, statistically estimating species-environment relationships, methods for inferring environmental conditions, statistical scripts in module.

  8. Diagnostic value of immunoglobulin κ light chain gene rearrangement analysis in B-cell lymphomas.

    Science.gov (United States)

    Kokovic, Ira; Jezersek Novakovic, Barbara; Novakovic, Srdjan

    2015-03-01

    Analysis of the immunoglobulin κ light chain (IGK) gene is an alternative method for B-cell clonality assessment in the diagnosis of mature B-cell proliferations in which the detection of clonal immunoglobulin heavy chain (IGH) gene rearrangements fails. The aim of the present study was to evaluate the added value of standardized BIOMED-2 assay for the detection of clonal IGK gene rearrangements in the diagnostic setting of suspected B-cell lymphomas. With this purpose, 92 specimens from 80 patients with the final diagnosis of mature B-cell lymphoma (37 specimens), mature T-cell lymphoma (26 specimens) and reactive lymphoid proliferation (29 specimens) were analyzed for B-cell clonality. B-cell clonality analysis was performed using the BIOMED-2 IGH and IGK gene clonality assays. The determined sensitivity of the IGK assay was 67.6%, while the determined sensitivity of the IGH assay was 75.7%. The sensitivity of combined IGH+IGK assay was 81.1%. The determined specificity of the IGK assay was 96.2% in the group of T-cell lymphomas and 96.6% in the group of reactive lesions. The determined specificity of the IGH assay was 84.6% in the group of lymphomas and 86.2% in the group of reactive lesions. The comparison of GeneScan (GS) and heteroduplex pretreatment-polyacrylamide gel electrophoresis (HD-PAGE) methods for the analysis of IGK gene rearrangements showed a higher efficacy of GS analysis in a series of 27 B-cell lymphomas analyzed by both methods. In the present study, we demonstrated that by applying the combined IGH+IGK clonality assay the overall detection rate of B-cell clonality was increased by 5.4%. Thus, we confirmed the added value of the standardized BIOMED-2 IGK assay for assessment of B-cell clonality in suspected B-cell lymphomas with inconclusive clinical and cyto/histological diagnosis.

  9. Detection of Adult Green Sturgeon Using Environmental DNA Analysis.

    Directory of Open Access Journals (Sweden)

    Paul S Bergman

    Full Text Available Environmental DNA (eDNA is an emerging sampling method that has been used successfully for detection of rare aquatic species. The Identification of sampling tools that are less stressful for target organisms has become increasingly important for rare and endangered species. A decline in abundance of the Southern Distinct Population Segment (DPS of North American Green Sturgeon located in California's Central Valley has led to its listing as Threatened under the Federal Endangered Species Act in 2006. While visual surveys of spawning Green Sturgeon in the Central Valley are effective at monitoring fish densities in concentrated pool habitats, results do not scale well to the watershed level, providing limited spatial and temporal context. Unlike most traditional survey methods, environmental DNA analysis provides a relatively quick, inexpensive tool that could efficiently monitor the presence and distribution of aquatic species. We positively identified Green Sturgeon DNA at two locations of known presence in the Sacramento River, proving that eDNA can be effective for monitoring the presence of adult sturgeon. While further study is needed to understand uncertainties of the sampling method, our study represents the first documented detection of Green Sturgeon eDNA, indicating that eDNA analysis could provide a new tool for monitoring Green Sturgeon distribution in the Central Valley, complimenting traditional on-going survey methods.

  10. Environmental impact analysis (EIA) concerning lodgepole pine forestry in Sweden

    International Nuclear Information System (INIS)

    Andersson, Bengt; Rosvall, Ola; Engelmark, Ola; Sjoeberg, Kjell

    1999-01-01

    This report presents an analysis of the ecological consequences of forestry with Canadian lodgepole pine introduced into Sweden. The report includes a compilation of present knowledge in the area, research priorities, and proposed measures for dealing with the negative environmental consequences that could arise. The point of departure of the analysis is a description of the properties of lodgepole pine, including species-specific characteristics of the tree, and changes in stand environment and silvicultural management practices that can be expected. The report describes the dispersal capacity of lodgepole pine in its new Swedish environment and the effects of host-parasite interactions. Thereafter, ecological effects on the capacity of the soil for sustainable production and on biological diversity at various scales (tree, stand, landscape) are analysed. Lodgepole pine forestry is also considered in relation to current laws and regulations as well as national and international environmental goals. At the end of the report, a strategy is proposed for handling the inevitable uncertainties associated with the introduction of exotic species 111 refs, 14 figs

  11. Occupational and environmental scleroderma. Systematic review and meta-analysis.

    Science.gov (United States)

    Rubio-Rivas, Manuel; Moreno, Rafael; Corbella, Xavier

    2017-03-01

    The etiology of systemic sclerosis (SSc) remains unknown; however, several occupational and environmental factors have been implicated. Our objective was to perform a meta-analysis of all studies published on SSc associated with occupational and environmental exposure. The review was undertaken by means of MEDLINE and SCOPUS from 1960 to 2014 and using the terms: "systemic," "scleroderma," or "systemic sclerosis/chemically induced" [MesH]. The Newcastle-Ottawa Scale was used for the qualifying assessment. The inverse variance-weighted method was performed. The meta-analysis of silica exposure included 15 case-control studies [overall OR 2.81 (95%CI 1.86-4.23; p < 0.001)] and 4 cohort studies [overall RR 17.52 (95%CI 5.98-51.37; p < 0.001)]; the meta-analysis of solvents exposure included 13 case-control studies (overall OR 2.00 [95%CI 1.32-3.02; p = 0.001); the meta-analysis of breast implants exposure included 4 case-control studies (overall OR 1.68 (95%CI 1.65-1.71; p < 0.001)) and 6 cohort studies (overall RR 2.13 (95%CI 0.86-5.27; p = 0.10)); the meta-analysis of epoxy resins exposure included 4 case-control studies (overall OR 2.97 (95%CI 2.31-3.83; p < 0.001)), the meta-analysis of pesticides exposure included 3 case-control studies (overall OR 1.02 (95%CI 0.78-1.32; p = 0.90)) and, finally, the meta-analysis of welding fumes exposure included 4 studies (overall OR 1.29 (95%CI 0.44-3.74; p = 0.64)). Not enough studies citing risks related to hair dyes have been published to perform an accurate meta-analysis. Silica and solvents were the two most likely substances related to the pathogenesis of SSc. While silica is involved in particular jobs, solvents are widespread and more people are at risk of having incidental contact with them.

  12. The reliability of mercury analysis in environmental materials

    International Nuclear Information System (INIS)

    Heinonen, J.; Suschny, O.

    1973-01-01

    Mercury occurs in nature in its native elemental as well as in different mineral forms. It has been mined for centuries and is used in many branches of industry, agriculture and medicine. Mercury is very toxic to man and reports of poisoning due to the presence of the element in fish and shellfish caught at Minamata and Niigata, Japan have led not only to local investigations but to multi-national research into the sources and the levels of mercury in the environment. The concentrations at which the element has to be determined in these studies are extremely small, usually of the order of a few parts in 10 9 parts of environmental material. Few analytical techniques provide the required sensitivity for analysis at such low concentrations, and only two are normally used for mercury: neutron activation analysis and atomic absorption photometry. They are also the most convenient end points of various separation schemes for different organic mercury compounds. Mercury analysis at the ppb-level is beset with many problems: volatility of the metal and its compounds, impurity of reagents, interference by other elements and many other analytical difficulties may influence the results. To be able to draw valid conclusions from the analyses it is necessary to know the reliability attached to the values obtained. To assist laboratories in the evaluation of their analytical performance, the International Atomic Energy Agency through its own laboratory at Seibersdorf already organised in 1967 an intercomparison of mercury analysis in flour. Based on the results obtained at that time, a whole series of intercomparisons of mercury determinations in nine different environmental materials was undertaken in 1971. The materials investigated included corn and wheat flour, spray-dried animal blood serum, fish solubles, milk powder, saw dust, cellulose, lacquer paint and coloric material

  13. The reliability of mercury analysis in environmental materials

    Energy Technology Data Exchange (ETDEWEB)

    Heinonen, J.; Suschny, O

    1973-01-01

    Mercury occurs in nature in its native elemental as well as in different mineral forms. It has been mined for centuries and is used in many branches of industry, agriculture and medicine. Mercury is very toxic to man and reports of poisoning due to the presence of the element in fish and shellfish caught at Minamata and Niigata, Japan have led not only to local investigations but to multi-national research into the sources and the levels of mercury in the environment. The concentrations at which the element has to be determined in these studies are extremely small, usually of the order of a few parts in 10{sup 9} parts of environmental material. Few analytical techniques provide the required sensitivity for analysis at such low concentrations, and only two are normally used for mercury: neutron activation analysis and atomic absorption photometry. They are also the most convenient end points of various separation schemes for different organic mercury compounds. Mercury analysis at the ppb-level is beset with many problems: volatility of the metal and its compounds, impurity of reagents, interference by other elements and many other analytical difficulties may influence the results. To be able to draw valid conclusions from the analyses it is necessary to know the reliability attached to the values obtained. To assist laboratories in the evaluation of their analytical performance, the International Atomic Energy Agency through its own laboratory at Seibersdorf already organised in 1967 an intercomparison of mercury analysis in flour. Based on the results obtained at that time, a whole series of intercomparisons of mercury determinations in nine different environmental materials was undertaken in 1971. The materials investigated included corn and wheat flour, spray-dried animal blood serum, fish solubles, milk powder, saw dust, cellulose, lacquer paint and coloric material.

  14. Environmental systems analysis of biogas systems; Miljoeanalys av biogassystem

    Energy Technology Data Exchange (ETDEWEB)

    Boerjesson, Paal; Berglund, Maria

    2003-05-01

    The purpose of this study is to analyse various biogas systems from an environmental point of view. The analyses are based on a systems analysis approach and an energy perspective. Biogas systems included are based on various combinations of substrates and final use of the biogas (heat, power and transportation fuel). The overall aims are to calculate fuel cycle emissions, quantify indirect environmental effects when various reference systems are replaced (e.g. current systems for waste treatment, agricultural production and energy generation), and to present data, calculations and results in a clear and transparent way, making the study useful for other environmental systems analyses. A general conclusion is that the environmental impact from biogas systems can vary significantly due to such factors as which substrate, energy service and reference system are chosen, and if indirect environmental effects and the need of systems enlargement are considered. The introduction of biogas systems normally leads to a reduced contribution of greenhouse gases, with some exceptions such as when biogas is used for heat and the alternative is combustion of the biomass. Biogas from manure seems to result in particularly large reductions due to indirect benefits in the form of reduced leakage of methane compared with conventional methods for handling and storing manure. A prerequisite is, however, that the losses of methane are small or that methane is combusted and thus converted into carbon dioxide. This study shows that the losses of methane can be up to 8-26%, due to what kind of biogas system is studied, before the contribution of greenhouse gases exceeds the contribution from reference systems based on fossil fuels. The contribution of emissions that leads to eutrophication and acidification is almost always reduced when biogas systems are introduced. The indirect environmental benefits could be significant for biogas based on sugar beet tops when leaving the beet tops at

  15. Problem Representation, Background Evidence, Analysis, Recommendation: An Oral Case Presentation Tool to Promote Diagnostic Reasoning.

    Science.gov (United States)

    Carter, Cristina; Akar-Ghibril, Nicole; Sestokas, Jeff; Dixon, Gabrina; Bradford, Wilhelmina; Ottolini, Mary

    2018-03-01

    Oral case presentations provide an opportunity for trainees to communicate diagnostic reasoning at the bedside. However, few tools exist to enable faculty to provide effective feedback. We developed a tool to assess diagnostic reasoning and communication during oral case presentations. Published by Elsevier Inc.

  16. The Application of Strength of Association Statistics to the Item Analysis of an In-Training Examination in Diagnostic Radiology.

    Science.gov (United States)

    Diamond, James J.; McCormick, Janet

    1986-01-01

    Using item responses from an in-training examination in diagnostic radiology, the application of a strength of association statistic to the general problem of item analysis is illustrated. Criteria for item selection, general issues of reliability, and error of measurement are discussed. (Author/LMO)

  17. Molecular tools for diagnosis of visceral leishmaniasis: systematic review and meta-analysis of diagnostic test accuracy

    NARCIS (Netherlands)

    de Ruiter, C. M.; van der Veer, C.; Leeflang, M. M. G.; Deborggraeve, S.; Lucas, C.; Adams, E. R.

    2014-01-01

    Molecular methods have been proposed as highly sensitive tools for the detection of Leishmania parasites in visceral leishmaniasis (VL) patients. Here, we evaluate the diagnostic accuracy of these tools in a meta-analysis of the published literature. The selection criteria were original studies that

  18. 78 FR 39284 - Technical Guidance for Assessing Environmental Justice in Regulatory Analysis

    Science.gov (United States)

    2013-07-01

    ... ENVIRONMENTAL PROTECTION AGENCY [EPA-HQ-OA-2013-0320; FRL-9830-1] Technical Guidance for Assessing Environmental Justice in Regulatory Analysis AGENCY: Environmental Protection Agency (EPA). ACTION: Notice... Environmental Protection Agency (EPA) issued for public comment a document entitled, ``Technical Guidance for...

  19. Industrial activity, gas emissions and environmental urban management. Operative condition's diagnostic of smelting activities in Tandil, Argentina

    International Nuclear Information System (INIS)

    Soledad Sosa, Beatriz; Guerrero, Elsa Marcela; Banda Noriega, Roxana

    2013-01-01

    Amongst urban environmental problems, those associated to industry are of particular interest in environmental management. Tandil, a city in Argentina, owes its economic and urban growth to metalworking activity, especially to smelting. Despite the crisis in the sector, activity continues to be the axis of local economic and urban growth. The present research characterizes, in production, operative and environmental terms, local smelting industries and assesses operative conditions of gas emissions management during 2010. There were analyzed 25 industries over 30. The sample was representative of five productive processes: aluminum (Al), aluminum/iron (Al Fe), aluminum/bronze (Al Cu+Sn), aluminum/iron/bronze (Al Fe Cu+Sn), and iron (Fe). The variables analyzed were: primary fusion mater, oven used and industry size. To obtain production data we applied structured interviews, and for industry sizes we used surveys. It was possible to describe the productive prospect of the sector at a local level: for most industries the destination of their production is automotive sector. Taking into account the relation between the size and the type of industry, the aluminum smelting companies are small. Regarding iron industries, all three company sizes are present in the sample and exists a medium size industry that occupies between 51 and 230 employees. The operative conditions and their compliance with current legislation regarding control of gas emissions require to identify monitoring indicators for the melting stage that allow knowing precisely the resulting contaminants and their environmental effects.

  20. Global Sensitivity Analysis of Environmental Models: Convergence, Robustness and Validation

    Science.gov (United States)

    Sarrazin, Fanny; Pianosi, Francesca; Khorashadi Zadeh, Farkhondeh; Van Griensven, Ann; Wagener, Thorsten

    2015-04-01

    Global Sensitivity Analysis aims to characterize the impact that variations in model input factors (e.g. the parameters) have on the model output (e.g. simulated streamflow). In sampling-based Global Sensitivity Analysis, the sample size has to be chosen carefully in order to obtain reliable sensitivity estimates while spending computational resources efficiently. Furthermore, insensitive parameters are typically identified through the definition of a screening threshold: the theoretical value of their sensitivity index is zero but in a sampling-base framework they regularly take non-zero values. There is little guidance available for these two steps in environmental modelling though. The objective of the present study is to support modellers in making appropriate choices, regarding both sample size and screening threshold, so that a robust sensitivity analysis can be implemented. We performed sensitivity analysis for the parameters of three hydrological models with increasing level of complexity (Hymod, HBV and SWAT), and tested three widely used sensitivity analysis methods (Elementary Effect Test or method of Morris, Regional Sensitivity Analysis, and Variance-Based Sensitivity Analysis). We defined criteria based on a bootstrap approach to assess three different types of convergence: the convergence of the value of the sensitivity indices, of the ranking (the ordering among the parameters) and of the screening (the identification of the insensitive parameters). We investigated the screening threshold through the definition of a validation procedure. The results showed that full convergence of the value of the sensitivity indices is not necessarily needed to rank or to screen the model input factors. Furthermore, typical values of the sample sizes that are reported in the literature can be well below the sample sizes that actually ensure convergence of ranking and screening.

  1. Bibliometric analysis of journal of clinical and diagnostic research (dentistry section; 2007-2014).

    Science.gov (United States)

    Jain, Swati; Basavaraj, P; Singla, Ashish; Singh, Khushboo; Kundu, Hansa; Vashishtha, Vaibhav; Pandita, Venisha; Malhi, Ravneet

    2015-04-01

    The role of scientific journals in diffusion of data concerning researches in the field of Public Health Dentistry is of premier importance. Bibliometric analysis involves analysis of publications reflecting the type of research work. The present study was conducted with an aim to determine the number and trends of published articles in Journal of Clinical and Diagnostic Research (JCDR) from Feb. 2007 to Oct.2014. A retrospective observational study was conducted for JCDR. All issues of JCDR were electronically searched for the parameters : study design, area of interest of research, state /college where research was conducted, authorship pattern, source of articles published each year, changing study trends, disease under study and publication bias. The data was organized and analyzed using software SPSS - version 21.0; descriptive statistics was used. Bibliometric analysis was done for 601 articles of JCDR published from Feb. 2007 to Oct. 2014. The total number of articles published under Dentistry section have tremendously increased from mere 2 articles in 2007 to 328 articles in 2014.Majority of the study designs published in both the journal were case reports (42.6%) followed by cross sectional studies (24.8%). 96.3% of the articles were from India. Majority of the articles published were of multi authors (65.2%) and from Educational institutes (98.4%). The trends of the articles published indicated that the case reports/series formed the major bulk (others=59.1%) followed by research studies (21.3%). It was concluded that most articles published were case reports followed by researches indicating an inclination towards better quality methodology. The SJR and the citation count of the articles published also indicated the quality of the scientific articles published.

  2. A study on the environmental impacts analysis with life cycle analysis of NPPs

    International Nuclear Information System (INIS)

    Jeong, H. S.; Moon, K. H.; Youn, S. W.

    2003-01-01

    This Life Cycle Analysis (LCA) work was accomplished based on the ISO-14040 framework goal and scope definition, including life cycle inventory analysis, and life cycle impact assessment. For the selection of impact categories, resource use, global affairs, local affairs, and nuclear specific affair were considered. It was unexpected that environmental burdens are generally heavier in an electricity generation process than in upper stream and fabrication processes, except ODP and ETPs. It has been normally thought that environmental burden in upper steam would be heavier than those in other processes. This misconception could have originated from the ambiguous thought for end-of-pipe emissions and life cycle inventories

  3. Simultaneity modeling analysis of the environmental Kuznets curve hypothesis

    International Nuclear Information System (INIS)

    Ben Youssef, Adel; Hammoudeh, Shawkat; Omri, Anis

    2016-01-01

    The environmental Kuznets curve (EKC) hypothesis has been recognized in the environmental economics literature since the 1990's. Various statistical tests have been used on time series, cross section and panel data related to single and groups of countries to validate this hypothesis. In the literature, the validation has always been conducted by using a single equation. However, since both the environment and income variables are endogenous, the estimation of a single equation model when simultaneity exists produces inconsistent and biased estimates. Therefore, we formulate simultaneous two-equation models to investigate the EKC hypothesis for fifty-six countries, using annual panel data from 1990 to 2012, with the end year is determined by data availability for the panel. To make the panel data analysis more homogeneous, we investigate this issue for a three income-based panels (namely, high-, middle-, and low-income panels) given several explanatory variables. Our results indicate that there exists a bidirectional causality between economic growth and pollution emissions in the overall panels. We also find that the relationship is nonlinear and has an inverted U-shape for all the considered panels. Policy implications are provided. - Highlights: • We have given a new look for the validity of the EKC hypothesis. • We formulate two-simultaneous equation models to validate this hypothesis for fifty-six countries. • We find a bidirectional causality between economic growth and pollution emissions. • We also discover an inverted U-shaped between environmental degradation and economic growth. • This relationship varies at different stages of economic development.

  4. VKTA Rossendorf: Laboratory for Environmental and Radionuclide Analysis

    International Nuclear Information System (INIS)

    Koehler, M.; Knappik, R.; Fiola, K.

    2015-01-01

    The VKTA (Nuclear Engineering and Analytics Inc.) is charged by the Free State of Saxony with the decommissioning and waste management of the nuclear installations at the research site Dresden-Rossendorf. This task includes the safe management and disposal of fissile material and radioactive wastes. The acquired expertise and our solution-oriented way of working are the basis for a varied range of services especially the environmental and radionuclide analyzes. The Laboratory for Environmental and Radionuclide Analysis is accredited according to DIN EN ISO/IEC 17025 and provides a sound range of analytical and metrological services including their coordination and management. The personnel and the rooms, measuring and technical equipment are particularly designed for our special field, the measuring of radioactivity. We are focussed on measuring artificial and natural radionuclides in a wide range of activity and in different sample matrices (e.g., urine, faeces, metals, soil, concrete, food, liquids). With the flexible accreditation of the radionuclide analytics the Laboratory is able to react shortly to changing requirements in decommissioning, environmental monitoring and radiation protection. Essential chemical and radiochemical methods are e.g.: · Alpha particle spectrometry, · Liquid scintillation counting, · gamma ray spectrometry, including Ultra-Low-Level, · High-resolution ICP-MS, · Chromatographic methods such as ion chromatography, gas chromatography, HPLC, · Electrochemical measuring methods such as potentiometry, voltammetry. The Laboratory offers analytical services to the research site Dresden-Rossendorf and national and international customers adapting its analytical procedures to the special needs of customers. The presentation demonstrates on the basis of examples the work of Laboratory within the scope of decommissioning of nuclear facilities, especially at a research site, from radiological preliminary investigation to declaration of

  5. Initial Northwest Power Act Power Sales Contracts : Final Environmental Impact Statement. Volume 1, Environmental Analysis.

    Energy Technology Data Exchange (ETDEWEB)

    United States. Bonneville Power Administration.

    1992-01-01

    This is volume 1 of the final environmental impact statement of the Bonneville Power Administration Information is included on the following: Purpose of and need for action; alternatives including the proposed action; affected environment; and environmental consequences.

  6. ANALYSIS AND QUANTITATIVE ASSESSMENT FOR RESULTS OF EDUCATIONAL PROGRAMS APPLICATION BY MEANS OF DIAGNOSTIC TESTS

    Directory of Open Access Journals (Sweden)

    E. L. Kon

    2015-07-01

    Full Text Available Subject of Research.The problem actuality for creation, control and estimation of results for competence-oriented educational programs is formulated and proved. Competences elements and components, assembled in modules, course units and parts of educational program, are defined as objects of control. Specific tasks of proficiency examination for competences and their components are stated; subject matter of the paper is formulated. Methods of Research. Some adapted statements and methods of technical science are offered to be applied for control tasks solution, decoding and estimation of education results. The approach to quantitative estimation of testing results with the use of additive integrated differential criterion of estimation is offered. Main Results. Statements, defining conditions of certain and uncertain (indeterminacy decision-making about proficiency examination for elements of discipline components controlled by test according to test realization results, are formulated and proved. Probabilistic characteristicsof both decision-making variants are estimated. Variants of determinate and fuzzy logic mathematic methods application for decreasing decision-making indeterminancy are offered; further research direction is selected for development of methods and algorithms for results decoding of diagnostic tests set realization. Practical Relevance. It is shown, that proposed approach to quantitative estimation of testing results will give the possibility to automate the procedure of formation and analysis for education results, specified in the competence format.

  7. Diagnostic prediction of renal failure from blood serum analysis by FTIR spectrometry and chemometrics

    Science.gov (United States)

    Khanmohammadi, Mohammdreza; Ghasemi, Keyvan; Garmarudi, Amir Bagheri; Ramin, Mehdi

    2015-02-01

    A new diagnostic approach based on Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectrometry and classification algorithm has been introduced which provides a rapid, reliable, and easy way to perform blood test for the diagnosis of renal failure. Blood serum samples from 35 renal failure patients and 40 healthy persons were analyzed by ATR-FTIR spectrometry. The resulting data was processed by Quadratic Discriminant Analysis (QDA) and QDA combined with simple filtered method. Spectroscopic studies were performed in 900-2000 cm-1 spectral region with 3.85 cm-1 data space. Results showed 93.33% and 100% of accuracy for QDA and filter-QDA models, respectively. In the first step, 30 samples were applied to construct the model. In order to modify the capability of QDA in prediction of test samples, filter-based feature selection methods were applied. It was found that the filtered spectra coupled with QDA could correctly predict the test samples in most of the cases.

  8. Biomarkers and Molecular Analysis to Improve Bloodstream Infection Diagnostics in an Emergency Care Unit

    Science.gov (United States)

    Loonen, Anne J. M.; de Jager, Cornelis P. C.; Tosserams, Janna; Kusters, Ron; Hilbink, Mirrian; Wever, Peter C.; van den Brule, Adriaan J. C.

    2014-01-01

    Molecular pathogen detection from blood is still expensive and the exact clinical value remains to be determined. The use of biomarkers may assist in preselecting patients for immediate molecular testing besides blood culture. In this study, 140 patients with ≥ 2 SIRS criteria and clinical signs of infection presenting at the emergency department of our hospital were included. C-reactive protein (CRP), neutrophil-lymphocyte count ratio (NLCR), procalcitonin (PCT) and soluble urokinase plasminogen activator receptor (suPAR) levels were determined. One ml EDTA blood was obtained and selective pathogen DNA isolation was performed with MolYsis (Molzym). DNA samples were analysed for the presence of pathogens, using both the MagicPlex Sepsis Test (Seegene) and SepsiTest (Molzym), and results were compared to blood cultures. Fifteen patients had to be excluded from the study, leaving 125 patients for further analysis. Of the 125 patient samples analysed, 27 presented with positive blood cultures of which 7 were considered to be contaminants. suPAR, PCT, and NLCR values were significantly higher in patients with positive blood cultures compared to patients without (p molecular assays perform poorly when one ml whole blood is used from emergency care unit patients. NLCR is a cheap, fast, easy to determine, and rapidly available biomarker, and therefore seems most promising in differentiating BSI from non-BSI patients for subsequent pathogen identification using molecular diagnostics. PMID:24475269

  9. Comparative analysis of cytological findings and diagnostic categories of independent сytopathologists

    Directory of Open Access Journals (Sweden)

    G V Semkina

    2013-09-01

    Full Text Available The article is devoted to the relevance of the application of the Bethesda classification system of interpretation of FNA in practice. In this study was investigated 104 cytological specimens of the thyroid gland from patients with var ious diseases of the thyroid gland. Revision of the cytological results was carried out by four highly qualified cytopathologists, working on the basis of three leading medical centers in the Russian Federation. Also, the respons es of each cytopathologist by diagnostic categories Bethesda Classification were compared. Statistical analysis showed that by the revision of the biopsy specimens there were no statistically significant differences between the ini tial cytologic findings and the results of independent cytopathologists. In analyzing the data, it was found that the fundamental error of cytological diagnosis were papillary carcinoma, medullary carcinoma, as well as “follicular neoplasm”. Comparing the results of histological examination with the responses of the cytopathologists was found that the major fault was the definition of papillary carcinoma and “follicular neoplasm”. The results suggest that Bethesda Classification allows to achieve the best results in the interpretation of the results of FNA, which leads to a more elaborate tactics of treatment of the patient.

  10. Pilot project for a commercial buildings Energy Analysis and Diagnostic Center (EADC) program. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Capehart, B.L.

    1996-02-01

    Commercial energy use costs businesses around $70 billion annually. Many of these businesses are small and medium sized organizations that do not have the resources to help themselves, or to pay for professional engineering services to help reduce their energy costs and improve their economic competitiveness. Energy cost reduction actions with payback times of around two years could save the commercial sector 15--20%, or $10--$15 billion per year. This project was initially intended to evaluate the feasibility of performing commercial energy audits as an adjunct to the industrial audit program run by the US Department of Energy Industrial Office. This program is housed in 30 universities throughout the United States. Formerly known as Energy Analysis and Diagnostic Centers (EADC`s), the university programs are now called Industrial Assessment Centers (IAC`s) to reflect their expansion from energy use analyses to include waste and productivity analyses. The success of the EADC/IAC program in helping the manufacturing sector provides an excellent model for a similar program in the commercial buildings sector. This project has investigated using the EADC/IAC approach to performing energy audits for the commercial sector, and has determined that such an approach is feasible and cost effective.

  11. Postindustrialization and Environmental Quality: An Empirical Analysis of the Environmental State

    Science.gov (United States)

    Fisher, Dana R.; Freudenburg, William R.

    2004-01-01

    Existing sociological analyses express differing expectations about state control over economic actors and the political feasibility of environmental regulation. Recent literature on the environmental state sees environmental protection as becoming a basic responsibility of postindustrial states, with economic actors no longer having the autonomy…

  12. Environmental policy assessment and the usefulness of meta-analysis

    Energy Technology Data Exchange (ETDEWEB)

    Button, K. [Loughborough Univ. of Technology (United Kingdom); Nijkamp, P. [Dept. of Spatial Economics. Fac. of Economics and Econometrics. Vrije Univ., Amsterdam (Netherlands)

    1995-12-31

    Incorporating environmental considerations fully into decision-making is a complex process. To develop improved assessment techniques and procedures it is important to understand these complexities. This paper sets out to explore the underlying nature of the issues involved and to develop a systematic schema which makes transparent the types of consideration which need to be incorporated in the assessment process and the forms of tradeoffs which are inevitable. It then proceeds to the more practical issue of looking at where better use could be made of the information that we already have. Environmental assessment is not new and a body of information and experience already exists. An important question is whether we are using the body of knowledge fully. The paper explores the areas in which meta-analysis could provide new insights in the assessment process by extracting more information from previous work but, in doing this, it also highlights areas where further primary research would yield the greatest return. 4 figs., 21 refs.

  13. Spatio-Temporal Analysis to Predict Environmental Influence on Malaria

    Science.gov (United States)

    Baig, S.; Sarfraz, M. S.

    2018-05-01

    Malaria is a vector borne disease which is a major cause of morbidity and mortality. It is one of the major diseases in the category of infectious diseases. The survival and bionomics of malaria is affected by environmental factors such as climatic, demographic and land-use/land-cover etc. Currently, a very few under developing countries are using Geo-informatics approaches to control this disease. Gujrat a district of Pakistan, is still under threat of malaria disease. Current research is carried on malaria incidents obtained from District Executive Officer of Health Gujrat. The objective of this study was to explore the spatio-temporal patterns of malaria in district Gujrat and to identify the areas being affected by Malaria. Furthermore, it has been also analyzed the relationship between malaria incident and environmental factors in highly favorable zones. Data is analyzed based on spatial and temporal patterns using (Moran's I). Moreover cluster and hot spots analysis were performed on the incident data. This study shows positive correlation with rainfall, vegetation index, population density and water bodies; while it shows positive and negative correlation with temperature in different seasons. However, variation between amount of vegetation and water bodies were observed. Finding of this research can help the decision makers to take preventive measures and reduce the morbidity and mortality related with malaria in Gujrat, Pakistan.

  14. Comparative cost analysis -- computed tomography vs. alternative diagnostic procedures, 1977-1980

    International Nuclear Information System (INIS)

    Gempel, P.A.; Harris, G.H.; Evans, R.G.

    1977-12-01

    In comparing the total national cost of utilizing computed tomography (CT) for medically indicated diagnoses with that of conventional x-ray, ultrasonography, nuclear medicine, and exploratory surgery, this investigation concludes that there was little, if any, added net cost from CT use in 1977 or will there be in 1980. Computed tomography, generally recognized as a reliable and useful diagnostic modality, has the potential to reduce net costs provided that an optimal number of units can be made available to physicians and patients to achieve projected reductions in alternative procedures. This study examines the actual cost impact of CT on both cranial and body diagnostic procedures. For abdominal and mediastinal disorders, CT scanning is just beginning to emerge as a diagnostic modality. As such, clinical experience is somewhat limited and the authors assume that no significant reduction in conventional procedures took place in 1977. It is estimated that the approximately 375,000 CT body procedures performed in 1977 represent only a 5 percent cost increase over use of other diagnostic modalities. It is projected that 2,400,000 CT body procedures will be performed in 1980 and, depending on assumptions used, total body diagnostic costs will increase only slightly or be reduced. Thirty-one tables appear throughout the text presenting cost data broken down by types of diagnostic procedures used and projections by years. Appendixes present technical cost components for diagnostic procedures, the comparative efficacy of CT as revealed in abstracts of published literature, selected medical diagnoses, and references

  15. Evaluating the accuracy of molecular diagnostic testing for canine visceral leishmaniasis using latent class analysis.

    Directory of Open Access Journals (Sweden)

    Manuela da Silva Solcà

    Full Text Available Host tissues affected by Leishmania infantum have differing degrees of parasitism. Previously, the use of different biological tissues to detect L. infantum DNA in dogs has provided variable results. The present study was conducted to evaluate the accuracy of molecular diagnostic testing (qPCR in dogs from an endemic area for canine visceral leishmaniasis (CVL by determining which tissue type provided the highest rate of parasite DNA detection. Fifty-one symptomatic dogs were tested for CVL using serological, parasitological and molecular methods. Latent class analysis (LCA was performed for accuracy evaluation of these methods. qPCR detected parasite DNA in 100% of these animals from at least one of the following tissues: splenic and bone marrow aspirates, lymph node and skin fragments, blood and conjunctival swabs. Using latent variable as gold standard, the qPCR achieved a sensitivity of 95.8% (CI 90.4-100 in splenic aspirate; 79.2% (CI 68-90.3 in lymph nodes; 77.3% (CI 64.5-90.1 in skin; 75% (CI 63.1-86.9 in blood; 50% (CI 30-70 in bone marrow; 37.5% (CI 24.2-50.8 in left-eye; and 29.2% (CI 16.7-41.6 in right-eye conjunctival swabs. The accuracy of qPCR using splenic aspirates was further evaluated in a random larger sample (n = 800, collected from dogs during a prevalence study. The specificity achieved by qPCR was 76.7% (CI 73.7-79.6 for splenic aspirates obtained from the greater sample. The sensitivity accomplished by this technique was 95% (CI 93.5-96.5 that was higher than those obtained for the other diagnostic tests and was similar to that observed in the smaller sampling study. This confirms that the splenic aspirate is the most effective type of tissue for detecting L. infantum infection. Additionally, we demonstrated that LCA could be used to generate a suitable gold standard for comparative CVL testing.

  16. The Accuracy of Diagnostic Methods for Diabetic Retinopathy: A Systematic Review and Meta-Analysis.

    Directory of Open Access Journals (Sweden)

    Vicente Martínez-Vizcaíno

    Full Text Available The objective of this study was to evaluate the accuracy of the recommended glycemic measures for diagnosing diabetic retinopathy.We systematically searched MEDLINE, EMBASE, the Cochrane Library, and the Web of Science databases from inception to July 2015 for observational studies comparing the diagnostic accuracy of glycated hemoglobin (HbA1c, fasting plasma glucose (FPG, and 2-hour plasma glucose (2h-PG. Random effects models for the diagnostic odds ratio (dOR value computed by Moses' constant for a linear model and 95% CIs were used to calculate the accuracy of the test. Hierarchical summary receiver operating characteristic curves (HSROC were used to summarize the overall test performance.Eleven published studies were included in the meta-analysis. The pooled dOR values for the diagnosis of retinopathy were 16.32 (95% CI 13.86-19.22 for HbA1c and 4.87 (95% CI 4.39-5.40 for FPG. The area under the HSROC was 0.837 (95% CI 0.781-0.892 for HbA1c and 0.735 (95% CI 0.657-0.813 for FPG. The 95% confidence region for the point that summarizes the overall test performance of the included studies occurs where the cut-offs ranged from 6.1% (43.2 mmol/mol to 7.8% (61.7 mmol/mol for HbA1c and from 7.8 to 9.3 mmol/L for FPG. In the four studies that provided information regarding 2h-PG, the pooled accuracy estimates for HbA1c were similar to those of 2h-PG; the overall performance for HbA1c was superior to that for FPG.The three recommended tests for the diagnosis of type 2 diabetes in nonpregnant adults showed sufficient accuracy for their use in clinical settings, although the overall accuracy for the diagnosis of retinopathy was similar for HbA1c and 2h-PG, which were both more accurate than for FPG. Due to the variability and inconveniences of the glucose level-based methods, HbA1c appears to be the most appropriate method for the diagnosis diabetic retinopathy.

  17. 30 CFR 250.227 - What environmental impact analysis (EIA) information must accompany the EP?

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false What environmental impact analysis (EIA... and Information Contents of Exploration Plans (ep) § 250.227 What environmental impact analysis (EIA... requirements. Your EIA must: (1) Assess the potential environmental impacts of your proposed exploration...

  18. Diagnostic value of serum squamous cell carcinoma antigen for hepatocellular carcinoma: a systematic review and meta-analysis.

    Science.gov (United States)

    Yu, Jing; Wang, Zhao-Juan; Chen, Long-Hua; Dong, Wen-Zhu

    2017-02-01

    The aim of this study was to ascertain the diagnostic value of serum squamous cell carcinoma antigen (SCCA) and SCCA-IgM for hepatocellular carcinoma (HCC). After a comprehensive search of PubMed and Web of Science databases, we identified eligible studies on the diagnostic value serum SCCAs for HCC. The quality of the eligible studies was assessed using the revised Quality Assessment for Studies of Diagnostic Accuracy (QUADAS-2) tool. The overall diagnostic value of SCCAs for HCC was pooled using a bivariate model. Twelve studies were included in this systematic review and meta-analysis. The pooled sensitivities for SCCA and SCCA-IgM were 0.61 (95% confidence interval [CI], 0.37-0.81) and 0.70 (95% CI, 0.55-0.82), respectively. The corresponding specificities were 0.80 (95% CI, 0.52-0.94) and 0.62 (95% CI, 0.51-0.72), respectively. The areas under summary receiver operating characteristic (sROC) curves for SCCA and SCCA-IgM were 0.76 (95% CI, 0.72-0.80) and 0.70 (95% CI, 0.66-0.74), respectively. Major design deficiencies of the included studies were two-gate design and partial verification bias. Therefore, we concluded that both serum SCCA and SCCA-IgM have a fair diagnostic value for HCC.

  19. Is hyperactivity ubiquitous in ADHD or dependent on environmental demands? Evidence from meta-analysis

    Science.gov (United States)

    Kofler, Michael J.; Raiker, Joseph S.; Sarver, Dustin E.; Wells, Erica L.; Soto, Elia F.

    2016-01-01

    Hyperactivity, or excess gross motor activity, is considered a core and ubiquitous characteristic of ADHD. Alternate models question this premise, and propose that hyperactive behavior reflects, to a large extent, purposeful behavior to cope with environmental demands that interact with underlying neurobiological vulnerabilities. The present review critically evaluates the ubiquity and environmental modifiability of hyperactivity in ADHD through meta-analysis of 63 studies of mechanically measured activity level in children, adolescents, and adults with ADHD relative to typically developing (TD) groups. Random effects models corrected for publication bias confirmed elevated gross motor activity in ADHD (d = 0.86); surprisingly, neither participant age (child vs. adult) nor the proportion of each ADHD sample diagnosed with the Inattentive subtype/presentation moderated this effect. In contrast, activity level assessed during high cognitive load conditions in general (d = 1.14) and high executive functioning demands in particular (d = 1.39) revealed significantly higher effect sizes than activity level during low cognitive load (d = 0.36) and in-class schoolwork (d = 0.50) settings. Low stimulation environments, more rigorous diagnostic practices, actigraph measurement of movement frequency and intensity, and ADHD samples that included fewer females were also associated with larger effects. Overall, the results are inconsistent with DSM-5 and ADHD models that a) describe hyperactivity as ubiquitous behavior, b) predict a developmental decline in hyperactivity, or c) differentiate subtypes/presentations according to perceived differences in hyperactive behavior. Instead, results suggest that the presence and magnitude of hyperactive behavior in ADHD may be influenced to a considerable extent by environmental factors in general, and cognitive/executive functioning demands in particular. PMID:27131918

  20. Systematic review and meta-analysis of studies evaluating diagnostic test accuracy: A practical review for clinical researchers-Part II. general guidance and tips

    International Nuclear Information System (INIS)

    Kim, Kyung Won; Choi, Sang Hyun; Huh, Jimi; Park, Seong Ho; Lee, June Young

    2015-01-01

    Meta-analysis of diagnostic test accuracy studies differs from the usual meta-analysis of therapeutic/interventional studies in that, it is required to simultaneously analyze a pair of two outcome measures such as sensitivity and specificity, instead of a single outcome. Since sensitivity and specificity are generally inversely correlated and could be affected by a threshold effect, more sophisticated statistical methods are required for the meta-analysis of diagnostic test accuracy. Hierarchical models including the bivariate model and the hierarchical summary receiver operating characteristic model are increasingly being accepted as standard methods for meta-analysis of diagnostic test accuracy studies. We provide a conceptual review of statistical methods currently used and recommended for meta-analysis of diagnostic test accuracy studies. This article could serve as a methodological reference for those who perform systematic review and meta-analysis of diagnostic test accuracy studies

  1. Preliminary Mass Spectrometric Analysis of Uranium on Environmental Swipe Materials

    International Nuclear Information System (INIS)

    Cheong, Chang-Sik; Jeong, Youn-Joong; Ryu, Jong-Sik; Shin, Hyung-Seon; Cha, Hyun-Ju; Ahn, Gil-Hoon; Park, Il-Jin; Min, Gyung-Sik

    2006-01-01

    It is well-known that uranium and plutonium isotopic compositions of safeguards samples are very useful to investigate the history of nuclear activities. To strengthen the capabilities of environmental sampling analysis in the ROK through MOST/DOE collaboration, round robin test for uranium and plutonium was designed in 2003. As the first round robin test, a set of dried uranium-containing solutions (∼35ng and (∼300ng) was distributed to the participating laboratories in November of 2003, with results reported in April of 2004. The KBSI (Korea Basic Science Institute) and ORNL (Oak Ridge National Laboratory) are currently in the process of analyzing uranium on cotton swipes for the second round robin test. As a preliminary test for the second round, KBSI intends to analyze home-made swipe samples into which international uranium standards are added. Here we describe technical steps of sample preparation and mass spectrometry at KBSI, and report some results of the preliminary test

  2. Small-scale wind power design, analysis, and environmental impacts

    CERN Document Server

    Abraham, John P

    2014-01-01

    In today's world, clean and robust energy sources are being sought to provide power to residences, commercial operations, and manufacturing enterprises. Among the most appealing energy sources is wind power-with its high reliability and low environmental impact. Wind power's rapid penetration into markets throughout the world has taken many forms, and this book discusses the types of wind power, as well as the appropriate decisions that need to be made regarding wind power design, testing, installation, and analysis. Inside, the authors detail the design of various small-wind systems including horizontal-axis wind turbines (HAWTs) and vertical-axis wind turbines (VAWTs). The design of wind turbines takes advantage of many avenues of investigation, all of which are included in the book. Analytical methods that have been developed over the past few decades are major methods used for design. Alternatively, experimentation (typically using scaled models in wind tunnels) and numerical simulation (using modern comp...

  3. Environmental Quality Information Analysis Center multi-year plan

    International Nuclear Information System (INIS)

    Rivera, R.G.; Das, S.; Walsh, T.E.

    1992-09-01

    An information analysis center (IAC) is a federal resource that provides technical information for a specific technology field. An IAC links an expert technical staff with an experienced information specialist group, supported by in-house or external data bases to provide technical information and maintain a corporate knowledge in a technical area. An IAC promotes the rapid transfer of technology among its users and provides assistance in adopting new technology and predicting and assessing emerging technology. This document outlines the concept, requirements, and proposed development of an Environmental Quality IAC (EQIAC). An EQIAC network is composed of several nodes, each of which has specific technology capabilities. This document outlines strategic and operational objectives for the phased development of one such node of an EQIAC network

  4. Wavelet and Spectral Analysis of Some Selected Problems in Reactor Diagnostics

    Energy Technology Data Exchange (ETDEWEB)

    Sunde, Carl

    2004-12-01

    Both spectral and wavelet analysis were successfully used in various diagnostic problems involving non-stationary core processes in nuclear power reactors. Three different problems were treated: two-phase flow identification, detector tube impacting and core-barrel vibrations. The first two problems are of non-stationary nature, whereas the last one is not. In the first problem, neutron radiographic and visible light images of four different vertical two-phase flow regimes, bubbly, slug, chum and annular flow, were analysed and classified with a neuro-wavelet algorithm. The algorithm consists of a wavelet part, using the 2-D discrete wavelet transform and of an artificial neural network. It classifies the different flow regimes with up to 99% efficiency. Detector tubes in a Boiling Water Reactor may execute vibrations and may also impact on nearby fuel-assemblies. Signals from in-core neutron detectors in Ringhals-1 were analysed, for detection of impacting, with both a classical spectral method and wavelet-based methods. The wavelet methods include both the discrete and the continuous 1-D wavelet transform. It was found that there is agreement between the different methods as well as with visual inspections made during the outage at the plant. However, the wavelet technique has the advantage that it does not require expert judgement for the interpretation of the analysis. In the last part two analytical calculations of the neutron noise, induced by shell-mode core-barrel vibrations, were carried out. The results are in good agreement with calculations from a numerical simulator. An out-of-phase behaviour between in-core and ex-core positions was found, which is in agreement with earlier measurements from the Pressurised Water Reactor Ringhals-3. The results from these calculations are planned to be used when diagnosing the shell-mode core-barrel vibrations in an operating plant.

  5. Wavelet and Spectral Analysis of Some Selected Problems in Reactor Diagnostics

    International Nuclear Information System (INIS)

    Sunde, Carl

    2004-12-01

    Both spectral and wavelet analysis were successfully used in various diagnostic problems involving non-stationary core processes in nuclear power reactors. Three different problems were treated: two-phase flow identification, detector tube impacting and core-barrel vibrations. The first two problems are of non-stationary nature, whereas the last one is not. In the first problem, neutron radiographic and visible light images of four different vertical two-phase flow regimes, bubbly, slug, chum and annular flow, were analysed and classified with a neuro-wavelet algorithm. The algorithm consists of a wavelet part, using the 2-D discrete wavelet transform and of an artificial neural network. It classifies the different flow regimes with up to 99% efficiency. Detector tubes in a Boiling Water Reactor may execute vibrations and may also impact on nearby fuel-assemblies. Signals from in-core neutron detectors in Ringhals-1 were analysed, for detection of impacting, with both a classical spectral method and wavelet-based methods. The wavelet methods include both the discrete and the continuous 1-D wavelet transform. It was found that there is agreement between the different methods as well as with visual inspections made during the outage at the plant. However, the wavelet technique has the advantage that it does not require expert judgement for the interpretation of the analysis. In the last part two analytical calculations of the neutron noise, induced by shell-mode core-barrel vibrations, were carried out. The results are in good agreement with calculations from a numerical simulator. An out-of-phase behaviour between in-core and ex-core positions was found, which is in agreement with earlier measurements from the Pressurised Water Reactor Ringhals-3. The results from these calculations are planned to be used when diagnosing the shell-mode core-barrel vibrations in an operating plant

  6. Metal speciation: survey of environmental methods of analysis

    Energy Technology Data Exchange (ETDEWEB)

    Mach, M.H.; Nott, B.; Scott, J.W.; Maddalone, R.F.; Whiddon, N.T. [TRW, Redondo Beach, CA (United States). Chemistry Technology Dept.

    1996-07-01

    As part of a recent task under the EPRI Analytical Methods Qualification Program (RP 1851), TRW has surveyed the methods available for monitoring metal species in typical utility aqueous discharge streams. Methods for determining the individual species of these metals can become important in a regulatory sense as the EPA transitions to assessment of environmental risk based on bioavailability. For example, EPA considers methyl mercury and Cr(VI) much more toxic to the aquatic environment than inorganic mercury or Cr(III). The species of a given element can also differ in their transport and bioaccumulation. Methods for speciation generally include a selective separation step followed by standard metals analysis. Speciation, therefore, is mainly derived from the separation step and not from the method of final quantisation. Examples of separation/analysis include: selective extraction followed by graphite furnace atomic absorption or ICP-MS; separation by GC followed by metals detection; chelation and/or direct separation by LC followed by UV measurement or metals detection; and ion chromatography with conductivity, UV, or metals detection. There are a number of sampling issues associated with metal species such as stabilization (maintaining oxidation state), absorption, and filtration that need to be addressed in order to obtain and maintain a representative sample for analysis. 45 refs., 1 tab.

  7. Conformity Assessment in Nuclear Material and Environmental Sample Analysis

    International Nuclear Information System (INIS)

    Aregbe, Y.; Jakopic, R.; Richter, S.; Venchiarutti, C.

    2015-01-01

    Safeguards conclusions are based to a large extent on comparison of measurement results between operator and safeguards laboratories. Measurement results must state traceability and uncertainties to be comparable. Recent workshops held at the IAEA and in the frame of the European Safeguards Research and Development Association (ESARDA), reviewed different approaches for Nuclear Material Balance Evaluation (MBE). Among those, the ''bottom-up'' approach requires assessment of operators and safeguards laboratories measurement systems and capabilities. Therefore, inter-laboratory comparisons (ILCs) with independent reference values provided for decades by JRC-IRMM, CEA/CETAMA and US DOE are instrumental to shed light on the current state of practice in measurements of nuclear material and environmental swipe samples. Participating laboratories are requested to report the measurement results with associated uncertainties, and have the possibility to benchmark those results against independent and traceable reference values. The measurement capability of both the IAEA Network of Analytical Laboratories (NWAL) and the nuclear operator's analytical services participating in ILCs can be assessed against the independent reference values as well as against internationally agreed quality goals, in compliance with ISO 13528:2005. The quality goals for nuclear material analysis are the relative combined standard uncertainties listed in the ITV2010. Concerning environmental swipe sample analysis, the IAEA defined measurement quality goals applied in conformity assessment. The paper reports examples from relevant inter-laboratory comparisons, looking at laboratory performance according to the purpose of the measurement and the possible use of the result in line with the IUPAC International Harmonized Protocol. Tendencies of laboratories to either overestimate and/or underestimate uncertainties are discussed using straightforward graphical tools to evaluate

  8. Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels (Conference Presentation)

    Science.gov (United States)

    Zhao, Jianhua; Zeng, Haishan; Kalia, Sunil; Lui, Harvey

    2017-02-01

    Background: Raman spectroscopy is a non-invasive optical technique which can measure molecular vibrational modes within tissue. A large-scale clinical study (n = 518) has demonstrated that real-time Raman spectroscopy could distinguish malignant from benign skin lesions with good diagnostic accuracy; this was validated by a follow-up independent study (n = 127). Objective: Most of the previous diagnostic algorithms have typically been based on analyzing the full band of the Raman spectra, either in the fingerprint or high wavenumber regions. Our objective in this presentation is to explore wavenumber selection based analysis in Raman spectroscopy for skin cancer diagnosis. Methods: A wavenumber selection algorithm was implemented using variably-sized wavenumber windows, which were determined by the correlation coefficient between wavenumbers. Wavenumber windows were chosen based on accumulated frequency from leave-one-out cross-validated stepwise regression or least and shrinkage selection operator (LASSO). The diagnostic algorithms were then generated from the selected wavenumber windows using multivariate statistical analyses, including principal component and general discriminant analysis (PC-GDA) and partial least squares (PLS). A total cohort of 645 confirmed lesions from 573 patients encompassing skin cancers, precancers and benign skin lesions were included. Lesion measurements were divided into training cohort (n = 518) and testing cohort (n = 127) according to the measurement time. Result: The area under the receiver operating characteristic curve (ROC) improved from 0.861-0.891 to 0.891-0.911 and the diagnostic specificity for sensitivity levels of 0.99-0.90 increased respectively from 0.17-0.65 to 0.20-0.75 by selecting specific wavenumber windows for analysis. Conclusion: Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels.

  9. ICP-MS applications for the analysis of geological materials and environmental samples

    International Nuclear Information System (INIS)

    Bendl, J.

    1997-01-01

    This work deals with applications of inductively coupled plasma - mass spectrometry applications for the analysis of geological materials and environmental samples. There are instrumentation, calibration, alternatives of sample introduction, interferences, trace elements analysis, rare earth elements and uranium and thorium, precious metals, isotopic analysis and environmental analysis discussed

  10. Cross-national diagnostic analysis of patient empowerment in England and Greece

    Directory of Open Access Journals (Sweden)

    Graham Lister

    2012-01-01

    Full Text Available Background: Different NHS patient empowerment policies have been adopted in England and Greece; the voluntary sector development and its influence also differ. Although various aspects of patient empowerment have been explored in England, the patient empowerment systems’ application is under-researched. In Greece, the few relevant attempts looking at patients’ experiences focus on patient satisfaction, with only one study exploring the public hospitals managers’ perspectives on user involvement. However, patient empowerment questions may be similar in both countries.Aims and Objectives:The study aimed to explore and compare the general patient empowerment settings in the two countries, with main objectives to:a. identify and explore the relationships of national voluntary and governmental organisations,b. explore the cross-national challenges and facilitators, and make cross-national recommendations.Methodology: This is a cross-national comparative research study. A ‘diagnostic analysis’ approach, an assessment of potential and actual barriers and facilitators, including the context and potential change, was chosen. The methods used were:a. a network analysis of national voluntary and governmental organisations;b. semi-structured interviews with key representatives of these, andc. documentary analysis.Results: The network analysis revealed the potential of English organisations to influence more people, withextensive memberships and stronger interrelationship between them than the Greek organisations. Different levels of awareness, knowledge and perceptions of application of the national patient empowerment policies, systems and mechanisms were identified; being generally good in England, limited in Greece. Variable generalinformation provision, with good verbal information in England, and limited, written and verbal, information in Greece was also identified. Although the commonest cross-national perceived challenges were

  11. 78 FR 56869 - Nuclear Infrastructure Programmatic Environmental Impact Statement Supplement Analysis...

    Science.gov (United States)

    2013-09-16

    ... DEPARTMENT OF ENERGY Nuclear Infrastructure Programmatic Environmental Impact Statement Supplement... of Energy (DOE) has completed the Supplement Analysis (SA) of the Programmatic Environmental Impact Statement for Accomplishing Expanded Civilian Nuclear Energy Research and Development and Isotope Production...

  12. Relating the environmental impact of consumption to household expenditures : An input-output analysis

    NARCIS (Netherlands)

    Kerkhof, Annemarie C.; Nonhebel, Sanderine; Moll, Henri C.

    2009-01-01

    In this paper we evaluate the relationships between household expenditures and the environmental impact categories climate change, acidification, eutrophication and smog formation, by combining household expenditures with environmentally extended input–output analysis. Expenditure elasticities are

  13. Pilot Dependence on Imperfect Diagnostic Automation in Simulated UAV Flights: An Attentional Visual Scanning Analysis

    National Research Council Canada - National Science Library

    Wickens, Christopher; Dixon, Stephen; Goh, Juliana; Hammer, Ben

    2005-01-01

    An unmanned air vehicle (UAV) simulation was designed to reveal the effects of imperfectly reliable diagnostic automation a monitor of system health parameters on pilot attention, as the latter was assessed via visual scanning...

  14. Exercise echocardiography or exercise SPECT imaging? - A meta-analysis of diagnostic test performance

    NARCIS (Netherlands)

    Fleischmann, KE; Hunink, MGM; Kuntz, KM; Douglas, PS

    1998-01-01

    Context.-Cardiac imaging has advanced rapidly, providing clinicians with several choices for evaluating patients with suspected coronary artery disease, but few studies compare modalities directly. .-To review the contemporary literature and to compare the diagnostic performance of exercise

  15. Critical Analysis of Methods for Integrating Economic and Environmental Indicators

    NARCIS (Netherlands)

    Huguet Ferran, Pau; Heijungs, Reinout; Vogtländer, Joost G.

    2018-01-01

    The application of environmental strategies requires scoring and evaluation methods that provide an integrated vision of the economic and environmental performance of systems. The vector optimisation, ratio and weighted addition of indicators are the three most prevalent techniques for addressing

  16. Delirium diagnosis defined by cluster analysis of symptoms versus diagnosis by DSM and ICD criteria: diagnostic accuracy study.

    Science.gov (United States)

    Sepulveda, Esteban; Franco, José G; Trzepacz, Paula T; Gaviria, Ana M; Meagher, David J; Palma, José; Viñuelas, Eva; Grau, Imma; Vilella, Elisabet; de Pablo, Joan

    2016-05-26

    Information on validity and reliability of delirium criteria is necessary for clinicians, researchers, and further developments of DSM or ICD. We compare four DSM and ICD delirium diagnostic criteria versions, which were developed by consensus of experts, with a phenomenology-based natural diagnosis delineated using cluster analysis of delirium features in a sample with a high prevalence of dementia. We also measured inter-rater reliability of each system when applied by two evaluators from distinct disciplines. Cross-sectional analysis of 200 consecutive patients admitted to a skilled nursing facility, independently assessed within 24-48 h after admission with the Delirium Rating Scale-Revised-98 (DRS-R98) and for DSM-III-R, DSM-IV, DSM-5, and ICD-10 criteria for delirium. Cluster analysis (CA) delineated natural delirium and nondelirium reference groups using DRS-R98 items and then diagnostic systems' performance were evaluated against the CA-defined groups using logistic regression and crosstabs for discriminant analysis (sensitivity, specificity, percentage of subjects correctly classified by each diagnostic system and their individual criteria, and performance for each system when excluding each individual criterion are reported). Kappa Index (K) was used to report inter-rater reliability for delirium diagnostic systems and their individual criteria. 117 (58.5 %) patients had preexisting dementia according to the Informant Questionnaire on Cognitive Decline in the Elderly. CA delineated 49 delirium subjects and 151 nondelirium. Against these CA groups, delirium diagnosis accuracy was highest using DSM-III-R (87.5 %) followed closely by DSM-IV (86.0 %), ICD-10 (85.5 %) and DSM-5 (84.5 %). ICD-10 had the highest specificity (96.0 %) but lowest sensitivity (53.1 %). DSM-III-R had the best sensitivity (81.6 %) and the best sensitivity-specificity balance. DSM-5 had the highest inter-rater reliability (K =0.73) while DSM-III-R criteria were the least

  17. Molecular diagnostics of periodontitis.

    Science.gov (United States)

    Korona-Głowniak, Izabela; Siwiec, Radosław; Berger, Marcin; Malm, Anna; Szymańska, Jolanta

    2017-01-28

    The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host's health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization) come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain reaction (PCR), real-time polymerase chain reaction (real-time PCR), 16S rRNA-encoding gene sequencing, checkerboard and reverse-capture checkerboard hybridization, microarrays, denaturing gradient gel electrophoresis (DGGE), temperature gradient gel electrophoresis (TGGE), as well as terminal restriction fragment length polymorphism (TRFLP) and next generation sequencing (NGS). The advantages and drawbacks of each method in the examination of periopathogens are indicated. The techniques listed above allow fast detection of even small quantities of pathogen present in diagnostic material and prove particularly useful to detect microorganisms that are difficult or impossible to grow in a laboratory.

  18. Molecular diagnostics of periodontitis

    Directory of Open Access Journals (Sweden)

    Izabela Korona-Głowniak

    2017-01-01

    Full Text Available The microorganisms that form dental plaque are the main cause of periodontitis. Their identification and the understanding of the complex relationships and interactions that involve these microorganisms, environmental factors and the host’s health status enable improvement in diagnostics and targeted therapy in patients with periodontitis. To this end, molecular diagnostics techniques (both techniques based on the polymerase chain reaction and those involving nucleic acid analysis via hybridization come increasingly into use. On the basis of a literature review, the following methods are presented: polymerase chain reaction (PCR, real-time polymerase chain reaction (real-time PCR, 16S rRNA-encoding gene sequencing, checkerboard and reverse-capture checkerboard hybridization, microarrays, denaturing gradient gel electrophoresis (DGGE, temperature gradient gel electrophoresis (TGGE, as well as terminal restriction fragment length polymorphism (TRFLP and next generation sequencing (NGS. The advantages and drawbacks of each method in the examination of periopathogens are indicated. The techniques listed above allow fast detection of even small quantities of pathogen present in diagnostic material and prove particularly useful to detect microorganisms that are difficult or impossible to grow in a laboratory.

  19. A Meta-Analysis of Typhoid Diagnostic Accuracy Studies: A Recommendation to Adopt a Standardized Composite Reference.

    Directory of Open Access Journals (Sweden)

    Helen L Storey

    Full Text Available Novel typhoid diagnostics currently under development have the potential to improve clinical care, surveillance, and the disease burden estimates that support vaccine introduction. Blood culture is most often used as the reference method to evaluate the accuracy of new typhoid tests; however, it is recognized to be an imperfect gold standard. If no single gold standard test exists, use of a composite reference standard (CRS can improve estimation of diagnostic accuracy. Numerous studies have used a CRS to evaluate new typhoid diagnostics; however, there is no consensus on an appropriate CRS. In order to evaluate existing tests for use as a reference test or inclusion in a CRS, we performed a systematic review of the typhoid literature to include all index/reference test combinations observed. We described the landscape of comparisons performed, showed results of a meta-analysis on the accuracy of the more common combinations, and evaluated sources of variability based on study quality. This wide-ranging meta-analysis suggests that no single test has sufficiently good performance but some existing diagnostics may be useful as part of a CRS. Additionally, based on findings from the meta-analysis and a constructed numerical example demonstrating the use of CRS, we proposed necessary criteria and potential components of a typhoid CRS to guide future recommendations. Agreement and adoption by all investigators of a standardized CRS is requisite, and would improve comparison of new diagnostics across independent studies, leading to the identification of a better reference test and improved confidence in prevalence estimates.

  20. The Revised Perceived Environmental Control Measure: A Review and Analysis.

    Science.gov (United States)

    Smith-Sebasto, N. J.

    1992-01-01

    A study reveals the need for extensive refinement of the Revised Perceived Environmental Control Measure purported in the past to be a reliable and valid instrument to measure the relationship between the psychological construct, "locus of control," and environmental action or environmentally responsible behavior. (MCO)

  1. Automated multivariate analysis of multi-sensor data submitted online: Real-time environmental monitoring.

    Science.gov (United States)

    Eide, Ingvar; Westad, Frank

    2018-01-01

    A pilot study demonstrating real-time environmental monitoring with automated multivariate analysis of multi-sensor data submitted online has been performed at the cabled LoVe Ocean Observatory located at 258 m depth 20 km off the coast of Lofoten-Vesterålen, Norway. The major purpose was efficient monitoring of many variables simultaneously and early detection of changes and time-trends in the overall response pattern before changes were evident in individual variables. The pilot study was performed with 12 sensors from May 16 to August 31, 2015. The sensors provided data for chlorophyll, turbidity, conductivity, temperature (three sensors), salinity (calculated from temperature and conductivity), biomass at three different depth intervals (5-50, 50-120, 120-250 m), and current speed measured in two directions (east and north) using two sensors covering different depths with overlap. A total of 88 variables were monitored, 78 from the two current speed sensors. The time-resolution varied, thus the data had to be aligned to a common time resolution. After alignment, the data were interpreted using principal component analysis (PCA). Initially, a calibration model was established using data from May 16 to July 31. The data on current speed from two sensors were subject to two separate PCA models and the score vectors from these two models were combined with the other 10 variables in a multi-block PCA model. The observations from August were projected on the calibration model consecutively one at a time and the result was visualized in a score plot. Automated PCA of multi-sensor data submitted online is illustrated with an attached time-lapse video covering the relative short time period used in the pilot study. Methods for statistical validation, and warning and alarm limits are described. Redundant sensors enable sensor diagnostics and quality assurance. In a future perspective, the concept may be used in integrated environmental monitoring.

  2. Automated multivariate analysis of multi-sensor data submitted online: Real-time environmental monitoring.

    Directory of Open Access Journals (Sweden)

    Ingvar Eide

    Full Text Available A pilot study demonstrating real-time environmental monitoring with automated multivariate analysis of multi-sensor data submitted online has been performed at the cabled LoVe Ocean Observatory located at 258 m depth 20 km off the coast of Lofoten-Vesterålen, Norway. The major purpose was efficient monitoring of many variables simultaneously and early detection of changes and time-trends in the overall response pattern before changes were evident in individual variables. The pilot study was performed with 12 sensors from May 16 to August 31, 2015. The sensors provided data for chlorophyll, turbidity, conductivity, temperature (three sensors, salinity (calculated from temperature and conductivity, biomass at three different depth intervals (5-50, 50-120, 120-250 m, and current speed measured in two directions (east and north using two sensors covering different depths with overlap. A total of 88 variables were monitored, 78 from the two current speed sensors. The time-resolution varied, thus the data had to be aligned to a common time resolution. After alignment, the data were interpreted using principal component analysis (PCA. Initially, a calibration model was established using data from May 16 to July 31. The data on current speed from two sensors were subject to two separate PCA models and the score vectors from these two models were combined with the other 10 variables in a multi-block PCA model. The observations from August were projected on the calibration model consecutively one at a time and the result was visualized in a score plot. Automated PCA of multi-sensor data submitted online is illustrated with an attached time-lapse video covering the relative short time period used in the pilot study. Methods for statistical validation, and warning and alarm limits are described. Redundant sensors enable sensor diagnostics and quality assurance. In a future perspective, the concept may be used in integrated environmental monitoring.

  3. Participatory Environmental Valuation: A Comparative Analysis of Four Case Studies

    Directory of Open Access Journals (Sweden)

    Leslie Carnoye

    2015-07-01

    Full Text Available The valuation of multiple ecosystem services requires the design of valuation processes able to integrate different dimensions of value and to cope with complexity. Following the “value-articulating institution” framework, we note that three core problems arise: the cognitive, normative and composition problems. Combining valuation methods, such as contingent valuation and multicriteria analysis, with participatory and deliberative techniques is increasingly promoted as a means to address those fundamental problems. However, the quality and legitimacy of the valuation process then becomes dependent on how participation is framed. We note that numerous issues need to be taken into account, such as the roles assumed by participants, the differences in contribution among participants, the level of participatory impact and the level of democratization of the decision-making process. This paper proposes a detailed qualitative analysis of four case studies, each of them having implemented a specific valuation method in a participatory process. We analyze how those cases were handled in each of the dimensions considered and offer our conclusions about the added values and remaining challenges related to participatory environmental valuation.

  4. Analysis of environmental friendliness of DUPIC fuel cycle

    International Nuclear Information System (INIS)

    Ko, Won Il; Kim, Ho Dong

    2001-07-01

    Some properties of irradiated DUPIC fuels are compared with those of other fuel cycles. It was indicated that the toxicity of the DUPIC option based on 1 GWe-yr is much smaller than those of other fuel cycle options, and is just about half the order of magnitude of other fuel cycles. From the activity analysis of 99 Tc and 237 Np, which are important to the long-term transport of fission products stored in geologic media, the DUPIC option, was being contained only about half of those other options. It was found from the actinide content estimation that the MOX option has the lowest plutonium arising based on 1 GWe-year and followed by the DUPIC option. However, fissile Pu content generated in the DUPIC fuel was the lowest among the fuel cycle options. From the analysis of radiation barrier in proliferation resistance aspect, the fresh DUPIC fuel can play a radiation barrier part, better than CANDU spent fuels as well as fresh MOX fuel. It is indicated that the DUPIC fuel cycle has the excellent resistance to proliferation, compared with an existing reprocessing option and CANDU once-through option. In conclusions, DUPIC fuel cycle would have good properties on environmental effect and proliferation resistance, compared to other fuel cycle cases

  5. Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis.

    Science.gov (United States)

    Li, Rui; Liu, Jianjun; Xue, Huiping; Huang, Gang

    2012-10-15

    The measurement of fecal tumor M2-pyruvate kinase (PKM2), overexpressed in tumor cells, has been proposed as a novel tool for detecting colorectal cancer (CRC). However, the sensitivity and specificity of this test varied among studies. The aim of this meta-analysis was to determine the diagnostic accuracy of fecal PKM2 for CRC and to evaluate its utility in the CRC screening. It was compared to guaiac fecal occult blood test (gFOBT) or immunological fecal occult blood test (iFOBT). Through comprehensive literature search, 10 studies met the inclusion criteria and were included. Summary estimates for sensitivity and specificity were calculated by using the bivariate random effect model. The hierarchical summary receiver operating characteristic curve was also undertaken. The overall sensitivity and specificity of fecal PKM2 for detecting CRC were 79% (95% CI = 75-83%) and 81% (95% CI = 73-87%), respectively. The summary positive predictive value and negative predictive value were 74% (95% CI = 56-87%) and 86% (95% CI = 79-91%), respectively. The pooled diagnostic odds ratio was 16 (95% CI = 10-26). In head-to-head comparison, the diagnostic odds ratio of PKM2 and gFOBT for CRC were 10.167 (95% CI = 5.992-17.250) and 6.557 (95% CI = 3.467-12.403), respectively. The diagnostic odds ratio of PKM2 and iFOBT for CRC were 9.542 (95% CI = 5.893-15.452) and 67.248 (95% CI = 16.194-279.26), respectively. The fecal PKM2 test was a diagnostic tool with moderate sensitivity and specificity for detecting CRC. Its diagnostic efficiency was similar to that of gFOBT. Because of its relatively low specificity and positive predict value, fecal PKM2 was not recommended used alone as a screening tool for CRC. Copyright © 2012 UICC.

  6. High-performance pickups for beam diagnostics. Design, analysis, characterization and implementation

    International Nuclear Information System (INIS)

    Angelovski, Aleksandar

    2015-01-01

    This work introduces the design, analysis, characterization and implementation of high-performance pickups for two beam diagnostic instruments, a Bunch Arrival-time Monitor (BAM) and an Energy Beam Position Monitor (EBPM) at the European XFEL. As a part of the BAM the cone-shaped pickups are proposed along with the corresponding RF-frontend. The designed pickups deliver a beam induced signal with a slope steepness of around 400 mV/ps and a bandwidth of 40 GHz. These signal characteristics are well inside the design requirements, i.e., a slope steepness of 300 mV/ps and more than ten times better compared to the signal from the state-of-the-art pickups. The pickups are installed and commissioned at three accelerator facilities, FLASH at DESY, the quasi-CW SRF accelerator ELBE at the Helmholtz-Zentrum Dresden-Rossendorf and the SwissFEL injector test facility at Paul Scherrer Institute. The obtained measurement results from the installed pickups are in good agreement with the simulations. A comparison between the signal measurements with the cone-shaped pickup and the state-of-the-art is performed at ELBE showing an improvement by a factor of ten. The potential of the pickups for sub-10 fs arrival-time measurements for bunch charges of 20 pC is demonstrated at ELBE and at SwissFEL injector test facility. The introduced coneshaped pickups are the first commercially available pickups with a bandwidth of up to 40 GHz. For the EBPM, a modular pickup structure with two types of planar pickups, microstrip transmission line and grounded coplanar waveguide with perpendicular connectors is investigated. The transition region between the connector and the line is optimized for two substrate materials, alumina and glass with a reflection coefficient better than -20 dB up to 6 GHz.

  7. Participatory Rural Appraisal for Diagnostic Analysis of spate irrigation systems in Raya Valley, Ethiopia

    Directory of Open Access Journals (Sweden)

    Giulio Castelli

    2017-05-01

    Full Text Available Spate irrigation is a complex and unique form of water management, which represent the main source of irrigation water in semi-arid river catchments. Water is diverted from seasonal rivers by using diversion structures made by stones, earth and brushwood, located within the river bed. The modernisation of spate irrigation realised in Raya Valley (northern Ethiopia resulted in disappointing performances. One of the main reasons for this failure was the poor consideration of the characteristics of seasonal catchments and local communities’ needs and preferences. Local farmers, who showed a deep knowledge of the river system, were involved only at the level of consultation. The aim of this research was to develop a participatory Diagnostic Analysis (DA for a traditional non-modernised spate irrigation system in Raya Valley, in order to involve local farmers within the development process, and to build a solid knowledge basis for effective improvements. A Participatory Rural Appraisal (PRA of the Harosha spate irrigation system was undertaken. PRA techniques focusing on spatial, temporal, socio-economical and spatiotemporal aspects of the system were performed with local farmers in order to identify and rank main problems and constraints to development. Farmers recognised the need of more resistant diversion structures and gabion walls for the stabilisation of the river bank. The involvement of farmers also helped to highlight that not only irrigation-related problems, but also flood-related problems threaten agricultural production and rural livelihoods. Rather than an irrigation system approach, an approach integrating irrigation development and flood risk mitigation is suggested for framing future development strategies.

  8. Class imbalance in unsupervised change detection - A diagnostic analysis from urban remote sensing

    Science.gov (United States)

    Leichtle, Tobias; Geiß, Christian; Lakes, Tobia; Taubenböck, Hannes

    2017-08-01

    Automatic monitoring of changes on the Earth's surface is an intrinsic capability and simultaneously a persistent methodological challenge in remote sensing, especially regarding imagery with very-high spatial resolution (VHR) and complex urban environments. In order to enable a high level of automatization, the change detection problem is solved in an unsupervised way to alleviate efforts associated with collection of properly encoded prior knowledge. In this context, this paper systematically investigates the nature and effects of class distribution and class imbalance in an unsupervised binary change detection application based on VHR imagery over urban areas. For this purpose, a diagnostic framework for sensitivity analysis of a large range of possible degrees of class imbalance is presented, which is of particular importance with respect to unsupervised approaches where the content of images and thus the occurrence and the distribution of classes are generally unknown a priori. Furthermore, this framework can serve as a general technique to evaluate model transferability in any two-class classification problem. The applied change detection approach is based on object-based difference features calculated from VHR imagery and subsequent unsupervised two-class clustering using k-means, genetic k-means and self-organizing map (SOM) clustering. The results from two test sites with different structural characteristics of the built environment demonstrated that classification performance is generally worse in imbalanced class distribution settings while best results were reached in balanced or close to balanced situations. Regarding suitable accuracy measures for evaluating model performance in imbalanced settings, this study revealed that the Kappa statistics show significant response to class distribution while the true skill statistic was widely insensitive to imbalanced classes. In general, the genetic k-means clustering algorithm achieved the most robust results

  9. Single Center Retrospective Analysis of Conventional and Radial TIG Catheters for Transradial Diagnostic Coronary Angiography.

    Science.gov (United States)

    Vorpahl, Marc; Koehler, Till; Foerst, Jason; Panagiotopoulos, Spyridon; Schleiting, Heinrich; Koss, Klaus; Ziegler, Gunda; Brinkmann, Hilmar; Seyfarth, Melchior; Tiroch, Klaus

    2015-01-01

    Current guidelines favor the radial approach for coronary angiography. Therefore, specialty radial diagnostic catheters were designed to engage both coronary arteries with a single device. However, it is unclear if single catheters are superior to conventional catheters. A retrospective analysis was performed of consecutive right radial coronary angiographies to determine catheter use, fluoroscopy time, radiation dosage, and consumption of contrast. Procedures were performed with a single TIG catheter or conventional catheters (CONV). Procedures with coronary artery bypass grafts or ventricular angiographies were excluded. 273 transradial procedures were performed successfully. 95 procedures were performed with CONV and 178 procedures with a TIG. Crossover to additional catheters was higher in TIG (15.2%) compared to CONV (5.3%, p = 0.02). Fluoroscopy time was comparable between CONV and TIG, without crossover (2.2 ± 1.2 min versus 2.3 ± 1.2 min; n.s.), however, greater in the case of crossover for CONV (5.8 ± 0.7) and TIG (7.6 ± 3.0; p = 0.0001). Radiation dosage was similar in CONV and the TIG, without crossover (1419 ± 1075, cGy∗cm(2) versus 1690 ± 1138; n.s.), however, greater for CONV (2374 ± 620) and TIG (3733 ± 2281, p = 0.05) with crossover. Overall, the amount of contrast was greater in TIG (56 ± 13 mL) versus CONV (48 ± 3 mL; p = 0.0003). CONV femoral catheters may be the primary choice for radial approach.

  10. Diagnostic Value of Manual and Computerized Methods of Dental Casts Analysis

    Directory of Open Access Journals (Sweden)

    H. Rahimi

    2009-06-01

    Full Text Available Objective: The aim of this study was to evaluate the validity of computerized and manual methods of dental cast analysis.Materials and Methods: Twenty set-ups of upper and lower casts using artificial teeth corresponding to various malocclusions were created for a diagnostic in vitro study. Values of tooth size were calculated from the isolated artificial teeth out of the set-ups, results were considered as a gold standard for the tooth size. Arch width was calculated from the existing set-ups on the dentins.Impressions were taken of the casts with alginate and duplicated with dental stone. Models were measured with digital caliper manually. Then images were taken from the occlusal views of the casts by a digital camera. Measurements were done on digital images with the AutoCAD software.The results of the computerized and manual methods were compared with the gold standard.Intra class correlation coefficient of reliability was used to measure the accuracy ofthe methods and the Friedman technique used to evaluate the significance of differences.Results: Results indicated that all measurements were highly correlated, e.g. gold standard and manual (0.9613-0.9991, gold standard and computerized (0.7118-0.9883, manual and computerized (0.6734-0.9914. Statistically significant differences were present between these methods (P<0.05, but they proved not to be clinically significant.Conclusion: Manual measurement is still the most accurate method when compared to the computerized measurements and the results of measurement by computer should be interpreted with caution.

  11. Green roof valuation: a probabilistic economic analysis of environmental benefits.

    Science.gov (United States)

    Clark, Corrie; Adriaens, Peter; Talbot, F Brian

    2008-03-15

    Green (vegetated) roofs have gained global acceptance as a technologythat has the potential to help mitigate the multifaceted, complex environmental problems of urban centers. While policies that encourage green roofs exist atthe local and regional level, installation costs remain at a premium and deter investment in this technology. The objective of this paper is to quantitatively integrate the range of stormwater, energy, and air pollution benefits of green roofs into an economic model that captures the building-specific scale. Currently, green roofs are primarily valued on increased roof longevity, reduced stormwater runoff, and decreased building energy consumption. Proper valuation of these benefits can reduce the present value of a green roof if investors look beyond the upfront capital costs. Net present value (NPV) analysis comparing a conventional roof system to an extensive green roof system demonstrates that at the end of the green roof lifetime the NPV for the green roof is between 20.3 and 25.2% less than the NPV for the conventional roof over 40 years. The additional upfront investment is recovered at the time when a conventional roof would be replaced. Increasing evidence suggests that green roofs may play a significant role in urban air quality improvement For example, uptake of N0x is estimated to range from $1683 to $6383 per metric ton of NOx reduction. These benefits were included in this study, and results translate to an annual benefit of $895-3392 for a 2000 square meter vegetated roof. Improved air quality leads to a mean NPV for the green roof that is 24.5-40.2% less than the mean conventional roof NPV. Through innovative policies, the inclusion of air pollution mitigation and the reduction of municipal stormwater infrastructure costs in economic valuation of environmental benefits of green roofs can reduce the cost gap that currently hinders U.S. investment in green roof technology.

  12. A critical analysis of the impact assessment of environmental tritium

    International Nuclear Information System (INIS)

    Jain, Narendra; Bhatia, Arvind

    2013-01-01

    Tritium, a radionuclide of hydrogen has longer life and gets more rapidly dispersed, but before becoming globally distributed, it represents a significant radiobiological risk to the local population exposed. It is produced naturally in the upper atmosphere by the interaction of cosmic rays with nitrogen and hydrogen. The tritons in the upper atmosphere are oxidized to tritiated water (HTO) and mix with the hydrosphere generally through the movement of air masses and precipitation. Terrestrially, tritium may be formed by the action of lithium on neutrons. There is apprehension that the recent controversy concerning the health and environmental impact of tritium may end up as worldwide contaminants in the final analysis. From many varied reports from different laboratories, it appears that projected levels for fusion reactors may also produce deleterious and detectable effects. The degree of concern over tritium problem is evidenced by a rapid increase in publications on the health implications of environmental tritium. The present issues of controversy will be intensified as the fusion reactor technology approaches the door step of public and the possible health detriment from its radioactive emissions arouse concern. The current project has been planned keeping some such points in view. It reviews the work on the behavior of tritium in its various forms in the environment with an emphasis on the release from various sources, its world inventories at present level sand its transfer into the various compartments of ecosystems. Besides this, its metabolism in biosystem and the possible implications of low doses of tritium in present and future generations have also been discussed. (author)

  13. Joint environmental and cost efficiency analysis of electricity generation

    International Nuclear Information System (INIS)

    Welch, Eric; Barnum, Darold

    2009-01-01

    Fossil-fuel based electricity generation produces the largest proportion of human-related carbon pollution in the United States. Hence, fuel choices by steam plants are key determinants of the industry's impact on national and global greenhouse gas emissions, and key foci for climate change policy. Yet, little research has been done to examine the economic and environmental tradeoffs among the different types of fuels that are used by these plants. This paper applies a Data Envelopment Analysis procedure that incorporates the materials balance principle to estimate the allocations of coal, gas and oil inputs that minimize carbon emissions and costs. Using EIA 906 and FERC 423 data, the paper estimates cost/carbon tradeoffs facing two sets of plants: those that use coal and gas inputs, and those that use coal, gas and oil inputs. Findings for our three-input sample show that there would be a 79% increase in cost for moving from the cost-efficient point to the carbon efficient point, while there would be a 38% increase in carbon for moving from the carbon efficient point to the cost-efficient point. These conclusions indicate that, in general, the gap between efficient cost and efficient environmental production is wide, and would require substantial policy intervention, technological change or market adjustment before it could be narrowed. However, our examination of individual plants shows that what is true in general is often not true for specific plants. Some plants that are currently less efficient than those on the production frontier could produce the same amount of electricity with less carbon output and less fuel input. Additionally, many plants on the production frontier could improve both cost and carbon efficiency by changing their mixture of fossil-fuel inputs. (author)

  14. Socio-environmental health analysis in Nogales, Sonora, Mexico

    Science.gov (United States)

    Norman, Laura M.; Caldeira, Felipe; Callegary, James; Gray, Floyd; O’ Rourke, Mary Kay; Meranza, Veronica; Van Rijn, Saskia

    2012-01-01

    In Nogales, Sonora, Mexico, some neighborhoods, or colonias, have intermittent delivery of water through pipes from the city of Nogales’s municipal water-delivery system while other areas lack piped water and rely on water delivered by truck or pipas. This research examined how lifestyles, water quality, and potential disease response, such as diarrhea, differs seasonally from a colonia with access to piped water as opposed to one using alternative water-delivery systems. Water samples were collected from taps or spigots at homes in two Nogales colonias. One colonia reflected high socio-environmental conditions where residents are supplied with municipal piped water (Colonia Lomas de Fatima); the second colonia reflected low socio-environmental conditions, lacking access to piped water and served by pipas (Colonia Luis Donaldo Colosio). A survey was developed and implemented to characterize perceptions of water quality, health impacts, and quality of life. Water samples were analyzed for microbial and inorganic water-quality parameters known to impact human health including, Escherichia coli (E. coli), total coliform bacteria, arsenic, and lead. A total of 21 households agreed to participate in the study (14 in Colosio and 7 in Fatima). In both colonias metal concentrations from water samples were all well below the United States Environmental Protection Agency’s (US EPA’s) maximum contaminant levels. E. coli concentrations exceeded the US EPA’s drinking-water standard in Colosio but not Fatima. Total coliform bacteria were present in over 50 % of households in both colonias. Microbial contamination was significantly higher in the summer than in the winter in both colonias. Resulting analysis suggests that residents in colonias without piped water are at a greater risk of gastrointestinal illness from consumption of compromised drinking water. Our survey corroborated reports of gastrointestinal illness in the summer months but not in the winter. Chloride

  15. Socio-Environmental Health Analysis in Nogales, Sonora, Mexico.

    Science.gov (United States)

    Norman, Laura M; Caldeira, Felipe; Callegary, James; Gray, Floyd; O' Rourke, Mary Kay; Meranza, Veronica; Van Rijn, Saskia

    2012-06-01

    In Nogales, Sonora, Mexico, some neighborhoods, or colonias, have intermittent delivery of water through pipes from the city of Nogales's municipal water-delivery system while other areas lack piped water and rely on water delivered by truck or pipas. This research examined how lifestyles, water quality, and potential disease response, such as diarrhea, differs seasonally from a colonia with access to piped water as opposed to one using alternative water-delivery systems. Water samples were collected from taps or spigots at homes in two Nogales colonias. One colonia reflected high socio-environmental conditions where residents are supplied with municipal piped water (Colonia Lomas de Fatima); the second colonia reflected low socio-environmental conditions, lacking access to piped water and served by pipas (Colonia Luis Donaldo Colosio). A survey was developed and implemented to characterize perceptions of water quality, health impacts, and quality of life. Water samples were analyzed for microbial and inorganic water-quality parameters known to impact human health including, Escherichia coli (E. coli), total coliform bacteria, arsenic, and lead. A total of 21 households agreed to participate in the study (14 in Colosio and 7 in Fatima). In both colonias metal concentrations from water samples were all well below the United States Environmental Protection Agency's (US EPA's) maximum contaminant levels. E. coli concentrations exceeded the US EPA's drinking-water standard in Colosio but not Fatima. Total coliform bacteria were present in over 50 % of households in both colonias. Microbial contamination was significantly higher in the summer than in the winter in both colonias. Resulting analysis suggests that residents in colonias without piped water are at a greater risk of gastrointestinal illness from consumption of compromised drinking water. Our survey corroborated reports of gastrointestinal illness in the summer months but not in the winter. Chloride was found

  16. Diagnostic value of tumor markers for lung adenocarcinoma-associated malignant pleural effusion: a validation study and meta-analysis.

    Science.gov (United States)

    Feng, Mei; Zhu, Jing; Liang, Liqun; Zeng, Ni; Wu, Yanqiu; Wan, Chun; Shen, Yongchun; Wen, Fuqiang

    2017-04-01

    Pleural effusion is one of the most common complications of lung adenocarcinoma and is diagnostically challenging. This study aimed to investigate the diagnostic performance of carcinoembryonic antigen (CEA), cytokeratin fragment (CYFRA) 21-1, and cancer antigen (CA) 19-9 for lung adenocarcinoma-associated malignant pleural effusion (MPE) through a validation study and meta-analysis. Pleural effusion samples were collected from 81 lung adenocarcinoma-associated MPEs and 96 benign pleural effusions. CEA, CYFRA 21-1, and CA19-9 were measured by electrochemiluminescence immunoassay. The capacity of tumor markers was assessed with receiver operating characteristic curve analyses and the area under the curve (AUC) was calculated. Standard methods for meta-analysis of diagnostic studies were used to summarize the diagnostic performance of CEA, CYFRA 21-1, and CA19-9 for lung adenocarcinoma-associated MPE. The pleural levels of CEA, CYFRA 21-1, and CA19-9 were significantly increased in lung adenocarcinoma-associated MPE compared to benign pleural effusion. The cut-off points for CEA, CYFRA 21-1, and CA19-9 were optimally set at 4.55 ng/ml, 43.10 μg/ml, and 12.89 U/ml, and corresponding AUCs were 0.93, 0.85, and 0.81, respectively. The combination of CEA, CYFRA 21-1, and CA19-9 increased the sensitivity to 95.06%, with an AUC of 0.95. Eight studies were included in this meta-analysis. CEA showed the best diagnostic performance with pooled sensitivity, specificity, positive/negative likelihood ratio, and diagnostic odds ratio of 0.75, 0.96, 16.01, 0.23, and 81.49, respectively. The AUC was 0.93. CEA, CYFRA 21-1, and CA19-9 play a role in the diagnosis of lung adenocarcinoma-associated MPE. The combination of these tumor markers increases the diagnostic accuracy.

  17. Diagnostic Accuracy of Rating Scales for Attention-Deficit/Hyperactivity Disorder: A Meta-analysis.

    Science.gov (United States)

    Chang, Ling-Yin; Wang, Mei-Yeh; Tsai, Pei-Shan

    2016-03-01

    The Child Behavior Checklist-Attention Problem (CBCL-AP) scale and Conners Rating Scale-Revised (CRS-R) are commonly used behavioral rating scales for diagnosing attention-deficit/hyperactivity disorder (ADHD) in children and adolescents. To evaluate and compare the diagnostic performance of CBCL-AP and CRS-R in diagnosing ADHD in children and adolescents. PubMed, Ovid Medline, and other relevant electronic databases were searched for articles published up to May 2015. We included studies evaluating the diagnostic performance of either CBCL-AP scale or CRS-R for diagnosing ADHD in pediatric populations in comparison with a defined reference standard. Bivariate random effects models were used for pooling and comparing diagnostic performance. We identified and evaluated 14 and 11 articles on CBCL-AP and CRS-R, respectively. The results revealed pooled sensitivities of 0.77, 0.75, 0.72, and 0.83 and pooled specificities of 0.73, 0.75, 0.84, and 0.84 for CBCL-AP, Conners Parent Rating Scale-Revised, Conners Teacher Rating Scale-Revised, and Conners Abbreviated Symptom Questionnaire (ASQ), respectively. No difference was observed in the diagnostic performance of the various scales. Study location, age of participants, and percentage of female participants explained the heterogeneity in the specificity of the CBCL-AP. CBCL-AP and CRS-R both yielded moderate sensitivity and specificity in diagnosing ADHD. According to the comparable diagnostic performance of all examined scales, ASQ may be the most effective diagnostic tool in assessing ADHD because of its brevity and high diagnostic accuracy. CBCL is recommended for more comprehensive assessments. Copyright © 2016 by the American Academy of Pediatrics.

  18. Using Remote Sensing Products for Environmental Analysis in South America

    Directory of Open Access Journals (Sweden)

    Fabrício Brito Silva

    2011-09-01

    Full Text Available Land cover plays a major role in many biogeochemical models that represent processes and connections with terrestrial systems; hence, it is a key component for public decisions in ecosystems management. The advance of remote sensing technology, combined with the emergence of new operational products, offers alternatives to improve the accuracy of environmental monitoring and analysis. This work uses the GLOBCOVER, the Vegetation Continuous Field (VCF, MODIS Fire Radiative Power (FRP and the Tropical Rainfall Measuring Mission (TRMM remotely sensed databases to analyze the biomass burning distribution, the land use and land cover characteristics and the percent of tree cover in South America during the years 2000 to 2005. Initially, GLOBCOVER was assessed based on VCF product, and subsequently used for quantitative analysis of the spatial distribution of the South America fires with the fire radiative power (FRP. The results show that GLOBCOVER has a tendency to overestimate forest classes and to underestimate urban and mangroves areas. The fire quantification based on GLOBCOVER product shows that the highest incidence of fires can be observed in the arc of deforestation, located in the Amazon forest border, with vegetation cover composed mainly of broadleaved evergreen or semi-deciduous forest. A time series analysis of FRP database indicates that biomass burning occurs mainly in areas of broadleaved evergreen or semi-deciduous forest and in Brazilian Cerrado associated with grassland management, agricultural land clearing and with the deforestation of Amazon tropical rainforest. Also, variations in FRP intensity and spread can be attributed to rainfall anomalies, such as in 2004, when South America had a positive anomaly rainfall.

  19. Biomedical visual data analysis to build an intelligent diagnostic decision support system in medical genetics.

    Science.gov (United States)

    Kuru, Kaya; Niranjan, Mahesan; Tunca, Yusuf; Osvank, Erhan; Azim, Tayyaba

    2014-10-01

    In general, medical geneticists aim to pre-diagnose underlying syndromes based on facial features before performing cytological or molecular analyses where a genotype-phenotype interrelation is possible. However, determining correct genotype-phenotype interrelationships among many syndromes is tedious and labor-intensive, especially for extremely rare syndromes. Thus, a computer-aided system for pre-diagnosis can facilitate effective and efficient decision support, particularly when few similar cases are available, or in remote rural districts where diagnostic knowledge of syndromes is not readily available. The proposed methodology, visual diagnostic decision support system (visual diagnostic DSS), employs machine learning (ML) algorithms and digital image processing techniques in a hybrid approach for automated diagnosis in medical genetics. This approach uses facial features in reference images of disorders to identify visual genotype-phenotype interrelationships. Our statistical method describes facial image data as principal component features and diagnoses syndromes using these features. The proposed system was trained using a real dataset of previously published face images of subjects with syndromes, which provided accurate diagnostic information. The method was tested using a leave-one-out cross-validation scheme with 15 different syndromes, each of comprised 5-9 cases, i.e., 92 cases in total. An accuracy rate of 83% was achieved using this automated diagnosis technique, which was statistically significant (pbenefits of using hybrid image processing and ML-based computer-aided diagnostics for identifying facial phenotypes. Copyright © 2014. Published by Elsevier B.V.

  20. Mass spectrometry-based serum proteome pattern analysis in molecular diagnostics of early stage breast cancer

    Directory of Open Access Journals (Sweden)

    Stobiecki Maciej

    2009-07-01

    Full Text Available Abstract Background Mass spectrometric analysis of the blood proteome is an emerging method of clinical proteomics. The approach exploiting multi-protein/peptide sets (fingerprints detected by mass spectrometry that reflect overall features of a specimen's proteome, termed proteome pattern analysis, have been already shown in several studies to have applicability in cancer diagnostics. We aimed to identify serum proteome patterns specific for early stage breast cancer patients using MALDI-ToF mass spectrometry. Methods Blood samples were collected before the start of therapy in a group of 92 patients diagnosed at stages I and II of the disease, and in a group of age-matched healthy controls (104 women. Serum specimens were purified and the low-molecular-weight proteome fraction was examined using MALDI-ToF mass spectrometry after removal of albumin and other high-molecular-weight serum proteins. Protein ions registered in a mass range between 2,000 and 10,000 Da were analyzed using a new bioinformatic tool created in our group, which included modeling spectra as a sum of Gaussian bell-shaped curves. Results We have identified features of serum proteome patterns that were significantly different between blood samples of healthy individuals and early stage breast cancer patients. The classifier built of three spectral components that differentiated controls and cancer patients had 83% sensitivity and 85% specificity. Spectral components (i.e., protein ions that were the most frequent in such classifiers had approximate m/z values of 2303, 2866 and 3579 Da (a biomarker built from these three components showed 88% sensitivity and 78% specificity. Of note, we did not find a significant correlation between features of serum proteome patterns and established prognostic or predictive factors like tumor size, nodal involvement, histopathological grade, estrogen and progesterone receptor expression. In addition, we observed a significantly (p = 0

  1. Array CGH Analysis and Developmental Delay: A Diagnostic Tool for Neurologists.

    Science.gov (United States)

    Cameron, F; Xu, J; Jung, J; Prasad, C

    2013-11-01

    Developmental delay occurs in 1-3% of the population, with unknown etiology in approximately 50% of cases. Initial genetic work up for developmental delay previously included chromosome analysis and subtelomeric FISH (fluorescent in situ hybridization). Array Comparative Genomic Hybridization (aCGH) has emerged as a tool to detect genetic copy number changes and uniparental disomy and is the most sensitive test in providing etiological diagnosis in developmental delay. aCGH allows for the provision of prognosis and recurrence risks, improves access to resources, helps limit further investigations and may alter medical management in many cases. aCGH has led to the delineation of novel genetic syndromes associated with developmental delay. An illustrative case of a 31-year-old man with long standing global developmental delay and recently diagnosed 4q21 deletion syndrome with a deletion of 20.8 Mb genomic interval is provided. aCGH is now recommended as a first line test in children and adults with undiagnosed developmental delay and congenital anomalies. Puce d'hybridation génomique comparative et retard de développement : un outil diagnostic pour les neurologues. Le retard de développement survient chez 1 à 3% de la population et son étiologie est inconnue chez à peu près 50% des cas. L'évaluation génétique initiale pour un retard de développement incluait antérieurement une analyse chromosomique et une analyse par FISH (hybridation in situ en fluorescence) de régions subtélomériques. La puce d'hybridation génomique comparative (CGHa) est devenue un outil de détection des changements du nombre de copies géniques ainsi que de la disomie uniparentale et elle est le test le plus sensible pour fournir un diagnostic étiologique dans le retard de développement. Le CGHa permet d'offrir un pronostic et un risque de récurrence, améliore l'accès aux ressources, aide à limiter les évaluations et peut modifier le traitement médical dans bien des cas

  2. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone.

    Science.gov (United States)

    Im, Hyungsoon; Castro, Cesar M; Shao, Huilin; Liong, Monty; Song, Jun; Pathania, Divya; Fexon, Lioubov; Min, Changwook; Avila-Wallace, Maria; Zurkiya, Omar; Rho, Junsung; Magaoay, Brady; Tambouret, Rosemary H; Pivovarov, Misha; Weissleder, Ralph; Lee, Hakho

    2015-05-05

    The widespread distribution of smartphones, with their integrated sensors and communication capabilities, makes them an ideal platform for point-of-care (POC) diagnosis, especially in resource-limited settings. Molecular diagnostics, however, have been difficult to implement in smartphones. We herein report a diffraction-based approach that enables molecular and cellular diagnostics. The D3 (digital diffraction diagnosis) system uses microbeads to generate unique diffraction patterns which can be acquired by smartphones and processed by a remote server. We applied the D3 platform to screen for precancerous or cancerous cells in cervical specimens and to detect human papillomavirus (HPV) DNA. The D3 assay generated readouts within 45 min and showed excellent agreement with gold-standard pathology or HPV testing, respectively. This approach could have favorable global health applications where medical access is limited or when pathology bottlenecks challenge prompt diagnostic readouts.

  3. Genetic and environmental influences on Diagnostic and Statistical Manual of Mental Disorders-Fifth Edition (DSM-5) maladaptive personality traits and their connections with normative personality traits.

    Science.gov (United States)

    Wright, Zara E; Pahlen, Shandell; Krueger, Robert F

    2017-05-01

    The Diagnostic and Statistical Manual for Mental Disorders-Fifth Edition (DSM-5) proposes an alternative model for personality disorders, which includes maladaptive-level personality traits. These traits can be operationalized by the Personality Inventory for the DSM-5 (PID-5). Although there has been extensive research on genetic and environmental influences on normative level personality, the heritability of the DSM-5 traits remains understudied. The present study addresses this gap in the literature by assessing traits indexed by the PID-5 and the International Personality Item Pool NEO (IPIP-NEO) in adult twins (N = 1,812 individuals). Research aims include (a) replicating past findings of the heritability of normative level personality as measured by the IPIP-NEO as a benchmark for studying maladaptive level traits, (b) ascertaining univariate heritability estimates of maladaptive level traits as measured by the PID-5, (c) establishing how much variation in personality pathology can be attributed to the same genetic components affecting variation in normative level personality, and (d) determining residual variance in personality pathology domains after variance attributable to genetic and environmental components of general personality has been removed. Results revealed that PID-5 traits reflect similar levels of heritability to that of IPIP-NEO traits. Further, maladaptive and normative level traits that correlate at the phenotypic level also correlate at the genotypic level, indicating overlapping genetic components contribute to variance in both. Nevertheless, we also found evidence for genetic and environmental components unique to maladaptive level personality traits, not shared with normative level traits. (PsycINFO Database Record (c) 2017 APA, all rights reserved).

  4. Serum tumor-associated autoantibodies as diagnostic biomarkers for lung cancer: A systematic review and meta-analysis.

    Directory of Open Access Journals (Sweden)

    Zhen-Ming Tang

    Full Text Available We performed a comprehensive review and meta-analysis to evaluate the diagnostic values of serum single and multiplex tumor-associated autoantibodies (TAAbs in patients with lung cancer (LC.We searched the MEDLINE and EMBASE databases for relevant studies investigating serum TAAbs for the diagnosis of LC. The primary outcomes included sensitivity, specificity and accuracy of the test.The systematic review and meta-analysis included 31 articles with single autoantibody and 39 with multiplex autoantibodies. Enzyme-linked immunosorbent assay (ELISA was the most common detection method. For the diagnosis of patients with all stages and early-stage LC, different single or combinations of TAAbs demonstrated different diagnostic values. Although individual TAAbs showed low diagnostic sensitivity, the combination of multiplex autoantibodies offered relatively high sensitivity. For the meta-analysis of a same panel of autoantibodies in patients at all stages of LC, the pooled results of the panel of 6 TAAbs (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1 and SOX2 were: sensitivity 38% (95% CI 0.35-0.40, specificity 89% (95% CI 0.86-0.91, diagnostic accuracy 65.9% (range 62.5-81.8%, AUC 0.52 (0.48-0.57, while the summary estimates of 7 TAAbs (p53, CAGE, NY-ESO-1, GBU4-5, SOX2, MAGE A4 and Hu-D were: sensitivity 47% (95% CI 0.34-0.60, specificity 90% (95% CI 0.89-0.92, diagnostic accuracy 78.4% (range 67.5-88.8%, AUC 0.90 (0.87-0.93. For the meta-analysis of the same panel of autoantibodies in patients at early-stage of LC, the sensitivities of both panels of 7 TAAbs and 6 TAAbs were 40% and 29.7%, while their specificities were 91% and 87%, respectively.Serum single or combinations of multiplex autoantibodies can be used as a tool for the diagnosis of LC patients at all stages or early-stage, but the combination of multiplex autoantibodies shows a higher detection capacity; the diagnostic value of the panel of 7 TAAbs is higher than the panel of 6 TAAbs, which

  5. Diagnostic accuracy of 64 multislice CT angiography in the assessment of coronary in-stent restenosis: A meta-analysis

    International Nuclear Information System (INIS)

    Sun Zhonghua; Almutairi, Abdulrahman Marzouq D.

    2010-01-01

    Purpose: The aim of this study was to perform a meta-analysis of the diagnostic accuracy of 64-slice CT angiography for the detection of coronary in-stent restenosis in patients treated with coronary stents when compared to conventional coronary angiography. Materials and methods: A search of PUBMED/MEDLINE, ProQuest and Cochrane library databases for English literature was performed. Only studies comparing 64-slice CT angiography with conventional coronary angiography for the detection of coronary in-stent restenosis (more than 50% stenosis) were included for analysis. Sensitivity and specificity estimates pooled across studies were tested using a fixed effects model. Results: Fourteen studies met selection criteria for inclusion in the analysis. The mean value of assessable stents was 89%. Prevalence of in-stent restenosis following coronary stenting was 20% among these studies. Pooled estimates of the sensitivity and specificity of overall 64-slice CT angiography for the detection of coronary in-stent restenosis was 90% (95% CI: 86%, 94%) and 91% (95% CI: 90%, 93%), respectively, based on the evaluation of assessable stents. Diagnostic value of 64-slice CT angiography was found to decrease significantly when the analysis was performed with inclusion of nonassessable segments in five studies, with pooled sensitivity and specificity being 79% (95% CI: 68%, 88%) and 81% (95% CI: 77%, 84%). Stent diameter is the main factor affecting the diagnostic value of 64-slice CT angiography. Conclusion: Our results showed that 64-slice CT angiography has high diagnostic value (both sensitivity and specificity) for detection of coronary in-stent restenosis based on assessable segments when compared to conventional coronary angiography.

  6. Exploration of analysis methods for diagnostic imaging tests: problems with ROC AUC and confidence scores in CT colonography.

    Science.gov (United States)

    Mallett, Susan; Halligan, Steve; Collins, Gary S; Altman, Doug G

    2014-01-01

    Different methods of evaluating diagnostic performance when comparing diagnostic tests may lead to different results. We compared two such approaches, sensitivity and specificity with area under the Receiver Operating Characteristic Curve (ROC AUC) for the evaluation of CT colonography for the detection of polyps, either with or without computer assisted detection. In a multireader multicase study of 10 readers and 107 cases we compared sensitivity and specificity, using radiological reporting of the presence or absence of polyps, to ROC AUC calculated from confidence scores concerning the presence of polyps. Both methods were assessed against a reference standard. Here we focus on five readers, selected to illustrate issues in design and analysis. We compared diagnostic measures within readers, showing that differences in results are due to statistical methods. Reader performance varied widely depending on whether sensitivity and specificity or ROC AUC was used. There were problems using confidence scores; in assigning scores to all cases; in use of zero scores when no polyps were identified; the bimodal non-normal distribution of scores; fitting ROC curves due to extrapolation beyond the study data; and the undue influence of a few false positive results. Variation due to use of different ROC methods exceeded differences between test results for ROC AUC. The confidence scores recorded in our study violated many assumptions of ROC AUC methods, rendering these methods inappropriate. The problems we identified will apply to other detection studies using confidence scores. We found sensitivity and specificity were a more reliable and clinically appropriate method to compare diagnostic tests.

  7. The analysis of distribution of the chromosome aberration breakpoints from medical diagnostic X-ray workers

    International Nuclear Information System (INIS)

    Wang Qin; Li Jin; Tang Weisheng; Wang Zhiquan

    2003-01-01

    Objective: To analyze the distribution of the chromosome aberration breakpoints from medical diagnostic x-ray workers. Methods: The breakpoints of lymphocyte chromosomes are analyzed using G-banding. Results: There are 146 breakpoints among 3545 metaphase in 37 cases of X-ray workers. There are statistically significant differences between observed values and expected values (χ 2 =42.82, df=23, P 0.05). Conclusion: The chromosome aberration breakpoints of medical diagnostic X-ray workers are non-random. The observed values of breakpoint numbers are higher than those of the expected values in 7 and 14 chromosomes (P<0.05)

  8. Environmental laws in Pakistan with case la w analysis

    International Nuclear Information System (INIS)

    Khan, M.S.

    2005-01-01

    Laws of Nature should be respected in the interest of the human race. It is very hard to go against them. Doing so will only result in the subsequent devastation of this earth and its inhabitants. The literal meaning of environment is 'life around us in which we all exist'. The word environment caught world attention after various protest and demonstrations by environmentalists' during the early 70s. Issues like Deforestation, Industrialization and Pollution in the urban cities of Pakistan are constantly increasing and are affecting the quality of life significantly. Increasing drudgeries regarding environmental issues have forced governing bodies and jurists to take some pragmatic action in the form of environmental laws. The legislature, executive and judiciary of Pakistan have yet not adequately and effectively realized this hard fact. It is also aggravating that the courts of law are reluctant to take a stand on this hard-core issue of environmental protection and preservation. The era from 1983 to 1997 appears to be the period of heightened environmental awareness in Pakistan. The very first Environmental Protection Ordinance 1983 was promulgated in this period, which laid the foundation stone of a new environmental legal system for Pakistan. A campaign started which worked hard for the enactment of Environmental Protection Act, 1997. This Act is not the last step but the best prevailing and available remedy for environment control in Pakistan. This research paper aims to analyze the development of environmental laws in Pakistan, important environmental statutes enacted in Pakistan, implementation and enforcement mechanisms contained in the Pakistan Environmental Protection Act, 1997, environmental treaties effective for Pakistan, public interest litigation, judicial activism, conclusions and suggestions. Specific emphasis will be on case law and the interpretation of environmental issues by the Pakistani Courts. In the end the repercussions of environment

  9. The Mini-Mental State Examination as a diagnostic and screening test for delirium: systematic review and meta-analysis.

    Science.gov (United States)

    Mitchell, Alex J; Shukla, Deepak; Ajumal, Hafsa A; Stubbs, Brendon; Tahir, Tayyeb A

    2014-01-01

    To analyse the evidence concerning the accuracy of the Mini-Mental State Examination (MMSE) as a diagnostic and screening test for the presence of delirium in adults. Two authors searched MEDLINE, PsychINFO and EMBASE from inception till March 2014. Articles were included that investigated the diagnostic validity of the MMSE to detect delirium against standardised criteria. A diagnostic validity meta-analysis was conducted. Thirteen studies were included representing 2017 patients in medical settings of whom 29.4% had delirium. The meta-analysis revealed the MMSE had an overall sensitivity and specificity estimate of 84.1% and 73.0%, but this was 81.1% and 82.8% in a subgroup analysis involving robust high quality studies. Sensitivity was unchanged but specificity was 68.4% (95% CI = 50.9-83.5%) in studies using a predefined cutoff of <24 to signify a case. In high-risk samples where delirium was present in 25% of patients, then the Positive predictive value and Negative predictive value would be 50.9% (48.3-66.2%) and 93.2% (90.0-96.5%). The MMSE cannot be recommended as a case-finding confirmatory test of delirium, but may be used as an initial screen to rule out high scorers who are unlikely to have delirium with approximately 93% accuracy. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. The importance of masticatory functional analysis in the diagnostic finding and treatment planning for prosthodontic rehabilitation

    Directory of Open Access Journals (Sweden)

    Harry Laksono

    2012-06-01

    Full Text Available Background: The masticatory system as a biologic system is subjected to harmful influences of varying severity. Almost half of routine patients requesting prosthodontic treatment indicated at least one sign or symptom of temporomandibular disorders. Analysis of the masticatory system often neglected by dentist. Untreated temporomandibular disorders may significantly implicated in the perpetuation of the disorder and may interfere with routine prosthodontic clinical procedures. It would be resulted unsuccessful long term goal of prosthodontic rehabilitation because of the uncompleted diagnoses and treatment plan. Purpose: The purpose of this case report was to give the information of the importance of masticatory functional analysis in the diagnostic finding for treatment planning in the prosthodontic rehabilitation. Case: A 45 year - old male patient, partial dentate with reduced chewing efficiency, mild pain in right preauricular region in function, left click in opening mouth, severe attrition on all anterior lower teeth with vertical dimension of occlusion decreased due to loss of posterior support. He wanted to make a new denture. Case management: Record and analyze of active and passive mandibular movement, opening pathway, muscle and temporomandibular joints palpation, load testing, and vertical dimension of occlusion with manual functional analysis (MFA, occlusal condition and radiographic examination. Treatment plan was formulated into 3 phases: stabilization of the masticatory system, definitive treatment and periodical control. The result of this treatment excellent for 1 year evaluation after permanent cementation. Conclusion: Masticatory functional analysis is very important and must be done in the diagnosis finding for treatment planning in every case of prosthodontic rehabilitation.Latar belakang: Sistem pengunyahan sebagai sistem biologis sewaktu-waktu dapat terjadi gangguan dengan berbagai derajat keparahan. Hampir setengah dari

  11. Comparative Analysis of Environmental Impacts of Selected Products

    Directory of Open Access Journals (Sweden)

    A. Fedoryszyn

    2013-01-01

    Full Text Available The purpose of the present study is to demonstrate that environmental impacts exerted by manufactured products throughout their entire life cycle are major aspects to be considered, alongside their functional features and cost-effectiveness. One of the available methods to evaluate environmental impacts is known to as the Life Cycle Assessment (LCA method.The study summarises the reports from the literature on the subject of environmental impact assessment. In conclusions, the authorsindicate the need for assessing the environmental impact of cast products made from conventional and newly introduced alloys.

  12. Comparative Analysis of Environmental Impacts of Selected Products

    Directory of Open Access Journals (Sweden)

    Fedoryszyn A.

    2013-03-01

    Full Text Available The purpose of the present study is to demonstrate that environmental impacts exerted by manufactured products throughout their entire life cycle are major aspects to be considered, alongside their functional features and cost-effectiveness. One of the available methods to evaluate environmental impacts is known to as the Life Cycle Assessment (LCA method. The study summarises the reports from the literature on the subject of environmental impact assessment. In conclusions, the authors indicate the need for assessing the environmental impact of cast products made from conventional and newly introduced alloys.

  13. Analysis of general specifications for nuclear facilities environmental monitoring vehicles

    International Nuclear Information System (INIS)

    Xu Xiaowei

    2014-01-01

    At present, with the nuclear energy more increasingly extensive application, the continuous stable radiation monitoring has become the focus of the public attention. The main purpose of the environmental monitoring vehicle for the continuous monitoring of the environmental radiation dose rate and the radionuclides concentration in the medium around nuclear facilities is that the environmental radiation level and the radioactive nuclides activity in the environment medium are measured. The radioactive pollution levels, the scope contaminated and the trends of the pollution accumulation are found out. The change trends for the pollution are observed and the monitoring results are explained. The domestic demand of the environmental monitoring for the nuclear facilities is shown in this report. The changes and demands of the routine environmental monitoring and the nuclear emergency monitoring are researched. The revision opinions for EJ/T 981-1995 General specifications for nuclear facilities environmental monitoring vehicles are put forward. The purpose is to regulate domestic environmental monitoring vehicle technical criterion. The criterion makes it better able to adapt and serve the environmental monitoring for nuclear facilities. The technical guarantee is provided for the environmental monitoring of the nuclear facilities. (authors)

  14. Environmental Efficiency Analysis of Listed Cement Enterprises in China

    Directory of Open Access Journals (Sweden)

    Fang Zhang

    2016-05-01

    Full Text Available China’s cement production has been the highest worldwide for decades and contributes significant environmental pollution. Using a non-radical DEA model with slacks-based measure (SBM, this paper analyzes the environmental efficiency of China’s listed cement companies. The results suggest that the average mean of the environmental efficiency for the listed cement enterprises shows a decreasing trend in 2012 and 2013. There is a significant imbalance in environmental efficiency in these firms ranging from very low to very high. Further investigation finds that enterprise size and property structure are key factors. Increasing production concentration and decreasing the share of government investment could improve the environmental efficiency. The findings also suggest that effectively monitoring pollution products can improve environmental efficiency quickly, whereas pursuit for excessive profitability without keeping the same pace in energy saving would cause a sharp drop in environmental efficiency. Based on these findings, we proposed that companies in the Chinese cement sector might consider restructuring to improve environmental efficiency. They also need to make a trade-off between profitability and environmental protection. Finally, the Chinese government should reduce ownership control and management interventions in cement companies.

  15. Semantic orchestration of image processing services for environmental analysis

    Science.gov (United States)

    Ranisavljević, Élisabeth; Devin, Florent; Laffly, Dominique; Le Nir, Yannick

    2013-09-01

    In order to analyze environmental dynamics, a major process is the classification of the different phenomena of the site (e.g. ice and snow for a glacier). When using in situ pictures, this classification requires data pre-processing. Not all the pictures need the same sequence of processes depending on the disturbances. Until now, these sequences have been done manually, which restricts the processing of large amount of data. In this paper, we present how to realize a semantic orchestration to automate the sequencing for the analysis. It combines two advantages: solving the problem of the amount of processing, and diversifying the possibilities in the data processing. We define a BPEL description to express the sequences. This BPEL uses some web services to run the data processing. Each web service is semantically annotated using an ontology of image processing. The dynamic modification of the BPEL is done using SPARQL queries on these annotated web services. The results obtained by a prototype implementing this method validate the construction of the different workflows that can be applied to a large number of pictures.

  16. Application of SIMS to the analysis of environmental samples

    International Nuclear Information System (INIS)

    Seyama, Haruhiko

    2003-01-01

    As an example of surface analysis of environmental samples, SIMS was applied to airborne particulates, fish otoliths (a calcareous ear-stone) and biotites (a rock-forming aluminosilicate mineral). Airborne particulates deposited on leaf surface were analyzed directly by fast atom bombardment (FAB)-SIMS using an O 2 primary neutral beam. Some metal elements, such as Pb, of aerosol origin could be detected. Local areas of a thin section of an otolith were analyzed by FAB-SIMS. Line scans and images of secondary ions revealed seasonal periodicity in Sr, Na and K concentrations in the otolith that corresponded to the annual band structure. Surface alteration of acid-treated and naturally weathered biotites was studied by SIMS depth profiling using an O - primary ion. The depth profile of the acid-treated biotite showed the formation of an altered surface layer rich in Si. In contrast a thick altered surface layer was not observed and Al was held on the surface under natural weathering

  17. Safety analysis factors for environmental restoration and decontamination and decommissioning

    International Nuclear Information System (INIS)

    Ellingson, D.R.

    1993-04-01

    Environmental restoration (ER) and facility decontamination/decommissioning (D ampersand D) operations can be grouped into two general categories. ''Nonstationary cleanup'' or simply ''cleanup'' activities are where the operation must relocate to the site of new contaminated material at the completion of each task (i.e., the operation moves to the contaminated material). ''Stationary production'' or simply ''production'' activities are where the contaminated material is moved to a centralized location (i.e., the contaminated material is moved to the operation) for analysis, sorting, treatment, storage, and disposal. This paper addresses the issue of nonstationary cleanup design. The following are the specific assigned action items: Collect and compile a list of special safety-related ER/D ampersand D design factors, especially ones that don't follow DOE Order 6430.1A requirements. Develop proposal of what makes sense to recommend to designers; especially consider recommendations for short-term projects. Present proposal at the January meeting. To achieve the action items, applicable US Department of Energy (DOE) design requirements, and cleanup operations and differences from production activities are reviewed and summarized; basic safety requirements influencing design are summarized; and finally, approaches, considerations, and methods for safe, cost-effective design of cleanup activities are discussed

  18. Visual Data Analysis as an Integral Part of Environmental Management

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Joerg; Bethel, E. Wes; Horsman, Jennifer L.; Hubbard, Susan S.; Krishnan, Harinarayan; Romosan,, Alexandru; Keating, Elizabeth H.; Monroe, Laura; Strelitz, Richard; Moore, Phil; Taylor, Glenn; Torkian, Ben; Johnson, Timothy C.; Gorton, Ian

    2012-10-01

    The U.S. Department of Energy's (DOE) Office of Environmental Management (DOE/EM) currently supports an effort to understand and predict the fate of nuclear contaminants and their transport in natural and engineered systems. Geologists, hydrologists, physicists and computer scientists are working together to create models of existing nuclear waste sites, to simulate their behavior and to extrapolate it into the future. We use visualization as an integral part in each step of this process. In the first step, visualization is used to verify model setup and to estimate critical parameters. High-performance computing simulations of contaminant transport produces massive amounts of data, which is then analyzed using visualization software specifically designed for parallel processing of large amounts of structured and unstructured data. Finally, simulation results are validated by comparing simulation results to measured current and historical field data. We describe in this article how visual analysis is used as an integral part of the decision-making process in the planning of ongoing and future treatment options for the contaminated nuclear waste sites. Lessons learned from visually analyzing our large-scale simulation runs will also have an impact on deciding on treatment measures for other contaminated sites.

  19. Biogas energy production in Ghana: environmental pollution analysis

    International Nuclear Information System (INIS)

    Akpabli, C.K.; Gyasi, S.

    1997-01-01

    Analysis of biomass fuel conversion options for biogas production at Appolonia in Ghana has demonstrated that the technique is promising not only for solving some of the country's energy and agricultural problems, but as a very useful way of waste treatment which should help improve waste management. Some environmental analyses were made and some of the preliminary results obtained are presented and discussed. There has been considerable decrease in both biochemical oxygen demand and biological oxygen demand of the effluents compared with the corresponding values obtained for the influents of the three most readily available biomass sources used - human faeces, cow dung and pig dung. Apart from methane (about 54%) and carbon dioxide (about 40%) the biogas produced at Appolonia , according to investigations, using a gas filter analyser and gas chromatography, was found to contain from 1 to 2% hydrogen sulphide which is poisonous. Two other components were detected in the gas but not identified in this present work. (author). 2 figs., 5 tabs., 8 refs

  20. Environmental assessment in The Netherlands: Effectively governing environmental protection? A discourse analysis

    Energy Technology Data Exchange (ETDEWEB)

    Runhaar, Hens, E-mail: h.a.c.runhaar@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Laerhoven, Frank van, E-mail: vanLaerhoven@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Driessen, Peter, E-mail: p.driessen@uu.nl [Utrecht University, Copernicus Institute of Sustainable Development, P.O. Box 80,115, 3508 TC Utrecht (Netherlands); Arts, Jos, E-mail: e.j.m.m.arts@rug.nl [University of Groningen, Faculty of Planning, P.O. Box 800, 9700 AV Groningen (Netherlands)

    2013-02-15

    Environmental assessment (EA) aims to enhance environmental awareness and to ensure that environmental values are fully considered in decision-making. In the EA arena, different discourses exist on what EA should aim for and how it functions. We hypothesise that these discourses influence its application in practice as well as its effectiveness in terms of achieving the above goals. For instance, actors who consider EA as a hindrance to fast implementation of their projects will probably apply it as a mandatory checklist, whereas actors who believe that EA can help to develop more environmentally sound decisions will use EIA as a tool to design their initiatives. In this paper we explore discourses on EA in The Netherlands and elaborate on their implications for EA effectiveness. Based on an innovative research design comprising an online survey with 443 respondents and 20 supplementary semi-structured interviews we conclude that the dominant discourse is that EA is mainly a legal requirement; EAs are conducted because they have to be conducted, not because actors choose to do so. EA effectiveness however seems reasonably high, as a majority of respondents perceive that it enhances environmental awareness and contributes to environmental protection. However, the 'legal requirement' discourse also results in decision-makers seldom going beyond what is prescribed by EA and environmental law. Despite its mandatory character, the predominant attitude towards EA is quite positive. For most respondents, EA is instrumental in providing transparency of decision-making and in minimising the legal risks of not complying with environmental laws. Differences in discourses seldom reflect extreme opposites. The 'common ground' regarding EA provides a good basis for working with EA in terms of meeting legal requirements but at the same time does not stimulate creativity in decision-making or optimisation of environmental values. In countries characterised by

  1. Environmental assessment in The Netherlands: Effectively governing environmental protection? A discourse analysis

    International Nuclear Information System (INIS)

    Runhaar, Hens; Laerhoven, Frank van; Driessen, Peter; Arts, Jos

    2013-01-01

    Environmental assessment (EA) aims to enhance environmental awareness and to ensure that environmental values are fully considered in decision-making. In the EA arena, different discourses exist on what EA should aim for and how it functions. We hypothesise that these discourses influence its application in practice as well as its effectiveness in terms of achieving the above goals. For instance, actors who consider EA as a hindrance to fast implementation of their projects will probably apply it as a mandatory checklist, whereas actors who believe that EA can help to develop more environmentally sound decisions will use EIA as a tool to design their initiatives. In this paper we explore discourses on EA in The Netherlands and elaborate on their implications for EA effectiveness. Based on an innovative research design comprising an online survey with 443 respondents and 20 supplementary semi-structured interviews we conclude that the dominant discourse is that EA is mainly a legal requirement; EAs are conducted because they have to be conducted, not because actors choose to do so. EA effectiveness however seems reasonably high, as a majority of respondents perceive that it enhances environmental awareness and contributes to environmental protection. However, the ‘legal requirement’ discourse also results in decision-makers seldom going beyond what is prescribed by EA and environmental law. Despite its mandatory character, the predominant attitude towards EA is quite positive. For most respondents, EA is instrumental in providing transparency of decision-making and in minimising the legal risks of not complying with environmental laws. Differences in discourses seldom reflect extreme opposites. The ‘common ground’ regarding EA provides a good basis for working with EA in terms of meeting legal requirements but at the same time does not stimulate creativity in decision-making or optimisation of environmental values. In countries characterised by less

  2. An automated smartphone-based diagnostic assay for point-of-care semen analysis

    Science.gov (United States)

    Kanakasabapathy, Manoj Kumar; Sadasivam, Magesh; Singh, Anupriya; Preston, Collin; Thirumalaraju, Prudhvi; Venkataraman, Maanasa; Bormann, Charles L.; Draz, Mohamed Shehata; Petrozza, John C.; Shafiee, Hadi

    2017-01-01

    Male infertility affects up to 12% of the world’s male population and is linked to various environmental and medical conditions. Manual microscope-based testing and computer-assisted semen analysis (CASA) are the current standard methods to diagnose male infertility; however, these methods are labor-intensive, expensive, and laboratory-based. Cultural and socially dominated stigma against male infertility testing hinders a large number of men from getting tested for infertility, especially in resource-limited African countries. We describe the development and clinical testing of an automated smartphone-based semen analyzer designed for quantitative measurement of sperm concentration and motility for point-of-care male infertility screening. Using a total of 350 clinical semen specimens at a fertility clinic, we have shown that our assay can analyze an unwashed, unprocessed liquefied semen sample with smartphone capabilities, can make remote semen quality testing accessible to people in both developed and developing countries who have access to smartphones. PMID:28330865

  3. An automated smartphone-based diagnostic assay for point-of-care semen analysis.

    Science.gov (United States)

    Kanakasabapathy, Manoj Kumar; Sadasivam, Magesh; Singh, Anupriya; Preston, Collin; Thirumalaraju, Prudhvi; Venkataraman, Maanasa; Bormann, Charles L; Draz, Mohamed Shehata; Petrozza, John C; Shafiee, Hadi

    2017-03-22

    Male infertility affects up to 12% of the world's male population and is linked to various environmental and medical conditions. Manual microscope-based testing and computer-assisted semen analysis (CASA) are the current standard methods to diagnose male infertility; however, these methods are labor-intensive, expensive, and laboratory-based. Cultural and socially dominated stigma against male infertility testing hinders a large number of men from getting tested for infertility, especially in resource-limited African countries. We describe the development and clinical testing of an automated smartphone-based semen analyzer designed for quantitative measurement of sperm concentration and motility for point-of-care male infertility screening. Using a total of 350 clinical semen specimens at a fertility clinic, we have shown that our assay can analyze an unwashed, unprocessed liquefied semen sample with time and provide the user a semen quality evaluation based on the World Health Organization (WHO) guidelines with ~98% accuracy. The work suggests that the integration of microfluidics, optical sensing accessories, and advances in consumer electronics, particularly smartphone capabilities, can make remote semen quality testing accessible to people in both developed and developing countries who have access to smartphones. Copyright © 2017, American Association for the Advancement of Science.

  4. ANALYSIS OF ENVIRONMENTAL FRAGILITY USING MULTI-CRITERIA ANALYSIS (MCE FOR INTEGRATED LANDSCAPE ASSESSMENT

    Directory of Open Access Journals (Sweden)

    Abimael Cereda Junior

    2014-01-01

    Full Text Available The Geographic Information Systems brought greater possibilitie s to the representation and interpretation of the landscap e as well as the integrated a nalysis. However, this approach does not dispense technical and methodological substan tiation for achieving the computational universe. This work is grounded in ecodynamic s and empirical analysis of natural and anthr opogenic environmental Fragility a nd aims to propose and present an integrated paradigm of Multi-criteria Analysis and F uzzy Logic Model of Environmental Fragility, taking as a case study of the Basin of Monjolinho Stream in São Carlos-SP. The use of this methodology allowed for a reduct ion in the subjectivism influences of decision criteria, which factors might have its cartographic expression, respecting the complex integrated landscape.

  5. Proposal for elicitation and analysis of environmental requirements into the construction design process: a case study

    Directory of Open Access Journals (Sweden)

    Camila Pegoraro

    2010-05-01

    Full Text Available Proposal: As new demands from sustainable development, environmental requirements arise as another challenge to design process management. It is already known that companies which design buildings are usually exposed to many managerial difficulties. Faced to the environmental demands, these companies require new facilities to align environmental requirements to the business goals and to include them properly in design process. This paper is based on a case study in a construction company, which was developed through interviews and document analysis. It is intended to present a procedure for the project environmental requirements elicitation, organization and analysis, which is based on the requirements engineering (ER concepts. As results it was concluded that the ER concepts are useful for the environmental requirements integration into the design process and that strategic planning should give directions for the effective environmental requirements adherence. Moreover, a procedure for environmental requirements modeling is proposed. Key-words: Design process, Requirements management, Environmental requirements, Construction

  6. Method for environmental risk analysis (MIRA) revision 2007; Metode for miljoerettet risikoanalyse (MIRA) revisjon 2007

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2007-04-15

    OLF's instruction manual for carrying out environmental risk analyses provides a united approach and a common framework for environmental risk assessments. This is based on the best information available. The manual implies standardizations of a series of parameters, input data and partial analyses that are included in the environmental risk analysis. Environmental risk analyses carried out according to the MIRA method will thus be comparable between fields and between companies. In this revision an update of the text in accordance with today's practice for environmental risk analyses and prevailing regulations is emphasized. Moreover, method adjustments for especially protected beach habitats have been introduced, as well as a general method for estimating environmental risk concerning fish. Emphasis has also been put on improving environmental risk analysis' possibilities to contribute to a better management of environmental risk in the companies (ml)

  7. Diagnostic accuracy of refractometry for assessing bovine colostrum quality: A systematic review and meta-analysis.

    Science.gov (United States)

    Buczinski, S; Vandeweerd, J M

    2016-09-01

    Provision of good quality colostrum [i.e., immunoglobulin G (IgG) concentration ≥50g/L] is the first step toward ensuring proper passive transfer of immunity for young calves. Precise quantification of colostrum IgG levels cannot be easily performed on the farm. Assessment of the refractive index using a Brix scale with a refractometer has been described as being highly correlated with IgG concentration in colostrum. The aim of this study was to perform a systematic review of the diagnostic accuracy of Brix refractometry to diagnose good quality colostrum. From 101 references initially obtain ed, 11 were included in the systematic review meta-analysis representing 4,251 colostrum samples. The prevalence of good colostrum samples with IgG ≥50g/L varied from 67.3 to 92.3% (median 77.9%). Specific estimates of accuracy [sensitivity (Se) and specificity (Sp)] were obtained for different reported cut-points using a hierarchical summary receiver operating characteristic curve model. For the cut-point of 22% (n=8 studies), Se=80.2% (95% CI: 71.1-87.0%) and Sp=82.6% (71.4-90.0%). Decreasing the cut-point to 18% increased Se [96.1% (91.8-98.2%)] and decreased Sp [54.5% (26.9-79.6%)]. Modeling the effect of these Brix accuracy estimates using a stochastic simulation and Bayes theorem showed that a positive result with the 22% Brix cut-point can be used to diagnose good quality colostrum (posttest probability of a good colostrum: 94.3% (90.7-96.9%). The posttest probability of good colostrum with a Brix value <18% was only 22.7% (12.3-39.2%). Based on this study, the 2 cut-points could be alternatively used to select good quality colostrum (sample with Brix ≥22%) or to discard poor quality colostrum (sample with Brix <18%). When sample results are between these 2 values, colostrum supplementation should be considered. Copyright © 2016 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.

  8. Temporal diagnostic analysis of the SWAT model to detect dominant periods of poor model performance

    Science.gov (United States)

    Guse, Björn; Reusser, Dominik E.; Fohrer, Nicola

    2013-04-01

    Hydrological models generally include thresholds and non-linearities, such as snow-rain-temperature thresholds, non-linear reservoirs, infiltration thresholds and the like. When relating observed variables to modelling results, formal methods often calculate performance metrics over long periods, reporting model performance with only few numbers. Such approaches are not well suited to compare dominating processes between reality and model and to better understand when thresholds and non-linearities are driving model results. We present a combination of two temporally resolved model diagnostic tools to answer when a model is performing (not so) well and what the dominant processes are during these periods. We look at the temporal dynamics of parameter sensitivities and model performance to answer this question. For this, the eco-hydrological SWAT model is applied in the Treene lowland catchment in Northern Germany. As a first step, temporal dynamics of parameter sensitivities are analyzed using the Fourier Amplitude Sensitivity test (FAST). The sensitivities of the eight model parameters investigated show strong temporal variations. High sensitivities were detected for two groundwater (GW_DELAY, ALPHA_BF) and one evaporation parameters (ESCO) most of the time. The periods of high parameter sensitivity can be related to different phases of the hydrograph with dominances of the groundwater parameters in the recession phases and of ESCO in baseflow and resaturation periods. Surface runoff parameters show high parameter sensitivities in phases of a precipitation event in combination with high soil water contents. The dominant parameters give indication for the controlling processes during a given period for the hydrological catchment. The second step included the temporal analysis of model performance. For each time step, model performance was characterized with a "finger print" consisting of a large set of performance measures. These finger prints were clustered into

  9. ANALYSIS OF PROPERTY STRUCTURE OF MEDICAL DIAGNOSTIC CONSULTATIVE CENTERS IN VARNA

    Directory of Open Access Journals (Sweden)

    Lyubomira Koeva-Dimitrova

    2016-06-01

    Full Text Available The production and financial performance of one company depend on the size of its assets and the aptness of the assets� proportion. The aim of this article is urged to make an external analysis of the asset structure of medical diagnostic and consultative centers (DCC in Varna and on this basis to draw conclusions regarding their property structure. Subject of the study is the annual financial statements, published in the Commercial Register, of all 9 in number DCCs that are registered in Varna. The names of DCC's are encoded with numbers from 1 to 9, with numbers from 1 to 7 are 6 DCCs, owned by the Municipality of Varna, one of them is a subsidiary of staterun hospital, with number 8 and 9 are private DCC's. Subject of the study are the assets and their proportion in the studied hospitals. The study covers 7 years - from year 2008 to year 2014. In the study are calculated and compared the indicators for intensity of the property as well as the relative share of the fixed assets obtained as an average value of the relative shares of all nine in number hospitals for the entire studied period. The following important conclusions have been made: 1 The average relative share of fixed assets of Varna DCCs for the period 2008 � 2014 is 56.85%. 2 The proportion of FA calculated only for municipal DCC's (average value is significantly higher - 72.75% compared to the overall average of 56.85%. 3 Private hospitals invest a lot less money in fixed assets than the municipal ones. 4 Since 2013 there is a slight increase of FA share in the private and the state-run DCC, and a slight decrease in the municipal ones (71.93. 5 The creation of an online database comprising of average indicators of the financial and property status of Bulgarian companies is essential and necessary condition for improving their competitiveness by providing reliable, accurate and usable information for comparison.

  10. Innovative Measurement Diagnostics for Analysis of Jet Interactions in Rotating Flowfields; TOPICAL

    International Nuclear Information System (INIS)

    AMATUCCI, VINCENT A.; BERESH, STEVEN J.; HENFLING, JOHN F.; ERVEN, ROCKY J.; BOURDON, CHRIS J.

    2002-01-01

    The present document summarizes the experimental efforts of a three-year study funded under the Laboratory Directed Research and Development program of Sandia National Laboratories. The Innovative Diagnostics LDRD project was designed to develop new measurement capabilities to examine the interaction of a propulsive spin jet in a transonic freestream for a model in a wind tunnel. The project motivation was the type of jet/fin interactions commonly occurring during deployment of weapon systems. In particular, the two phenomena of interest were the interaction of the propulsive spin jet with the freestream in the vicinity of the nozzle and the impact of the spin rocket plume and its vortices on the downstream fins. The main thrust of the technical developments was to incorporate small-size, Lagrangian sensors for pressure and roll-rate on a scale model and include data acquisition, transmission, and power circuitry onboard. FY01 was the final year of the three-year LDRD project and the team accomplished much of the project goals including use of micron-scale pressure sensors, an onboard telemetry system for data acquisition and transfer, onboard jet exhaust, and roll-rate measurements. A new wind tunnel model was designed, fabricated, and tested for the program which incorporated the ability to house multiple MEMS-based pressure sensors, interchangeable vehicle fins with pressure instrumentation, an onboard multiple-channel telemetry data package, and a high-pressure jet exhaust simulating a spin rocket motor plume. Experiments were conducted for a variety of MEMS-based pressure sensors to determine performance and sensitivity in order to select pressure transducers for use. The data acquisition and analysis path was most successful by using multiple, 16-channel data processors with telemetry capability to a receiver outside the wind tunnel. The development of the various instrumentation paths led to the fabrication and installation of a new wind tunnel model for

  11. An integrated real-time diagnostic concept using expert systems, qualitative reasoning and quantitative analysis

    International Nuclear Information System (INIS)

    Edwards, R.M.; Lee, K.Y.; Kumara, S.; Levine, S.H.

    1989-01-01

    An approach for an integrated real-time diagnostic system is being developed for inclusion as an integral part of a power plant automatic control system. In order to participate in control decisions and automatic closed loop operation, the diagnostic system must operate in real-time. Thus far, an expert system with real-time capabilities has been developed and installed on a subsystem at the Experimental Breeder Reactor (EBR-II) in Idaho, USA. Real-time simulation testing of advanced power plant concepts at the Pennsylvania State University has been developed and was used to support the expert system development and installation at EBR-II. Recently, the US National Science Foundation (NSF) and the US Department of Energy (DOE) have funded a Penn State research program to further enhance application of real-time diagnostic systems by pursuing implementation in a distributed power plant computer system including microprocessor based controllers. This paper summarizes past, current, planned, and possible future approaches to power plant diagnostic systems research at Penn State. 34 refs., 9 figs

  12. Integrating exhaled breath diagnostics by disease-sniffing dogs with instrumental laboratory analysis

    Science.gov (United States)

    Dogs have been studied for many years as a medical diagnostic tool to detect a pre-clinical disease state by sniffing emissions directly from a human or an in vitro biological sample. Some of the studies report high sensitivity and specificity in blinded case-control studies. How...

  13. Cost-effectiveness analysis of various strategies in the diagnostic management of pulmonary embolism

    NARCIS (Netherlands)

    Oudkerk, M.; van Beek, E. J.; van Putten, W. L.; Büller, H. R.

    1993-01-01

    Since the clinical diagnosis of pulmonary embolism is unreliable, various objective diagnostic methods (or combinations thereof) are advocated. Pulmonary angiography is the accepted reference method but is considered less suitable for initial screening due to its invasive nature. Therefore, at least

  14. Value of multi-criteria decision analysis in early assessment of medical diagnostic devices

    NARCIS (Netherlands)

    IJzerman, Maarten Joost; Hummel, J. Marjan

    2010-01-01

    OBJECTIVES: Multicriteria decision analytic (MCDA) techniques are a powerful tool in evaluating health care interventions where multiple, often competing, factors need to be considered. The analytic hierarchy process (AHP) is one such technique. We have applied AHP to evaluate medical diagnostic

  15. Morphological Processing of Ultraviolet Emissions of Electrical Corona Discharge for Analysis and Diagnostic Use

    Science.gov (United States)

    Schubert, Matthew R.; Moore, Andrew J.

    2015-01-01

    Electron cascades from electrical discharge produce secondary emissions from atmospheric plasma in the ultraviolet band. For a single point of discharge, these emissions exhibit a stereotypical discharge morphology, with latent information about the discharge location. Morphological processing can uncover the location and therefore can have diagnostic utility.

  16. Radiation and environmental data analysis computer (REDAC) hardware, software band analysis procedures

    International Nuclear Information System (INIS) </